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<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GNY6</accession>
    <name>A0A914GNY6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GNY6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10001.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10001.t1"/>
        <property type="gene ID" value="Gr19_v10_g10001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10001.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8730" checksum="678DE52E298D15EA" modified="2023-02-22" version="1">MPRPIHPHPPFLPPAQMSMPVRPQPTVFSLAPGLLPMPAKLPLHFFPPLARVMTVNPPCTTIATTANNAADYATTPRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPR5</accession>
    <name>A0A914GPR5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPR5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10293.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10293.t1"/>
        <property type="gene ID" value="Gr19_v10_g10293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10293.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23349" checksum="6EE40FCDDECBA404" modified="2023-02-22" version="1">MEMAALKVQNSAIKFAQILEDNPKIRENTQKAEENAKNDAQLDKFELLQWKSLLFKNNLTNVKIDRLMESVYLAFNGFVKALNEPKCQNIRQLCPMAMPATTGRRRRRQMDTIRGTFGIEQPPQAPQGHGGPEMCTCGWCQFVGLLVLGILSFISIIIAYSMLKHNASHQNILFMCGSVAVFLCSVGAWLKVYTTLCNNCCANNNNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQZ4</accession>
    <name>A0A914GQZ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQZ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10494.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10494.t2"/>
        <property type="gene ID" value="Gr19_v10_g10494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10494.t2"/>
        </source>
    </evidence>
    <sequence length="156" mass="16761" checksum="230E12E3AEB6F5FB" modified="2023-02-22" version="1">MMGSVRSDSRFDCPQTLFSLDDGENVSEDFPVGEAASKLLSVGVPCGRREQKVRGGSGRTDGIGKTASSAVKKSDSLLIDEVELDGGAPRDFDGASDDENDFLPVALGTKIATGLGENTRANSTVHWQNRVRLRLKRVSTVFGCCFPWAAGFNQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRW6</accession>
    <name>A0A914GRW6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major antigen</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g10728.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10728.t1"/>
        <property type="gene ID" value="Gr19_v10_g10728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057531">
        <property type="entry name" value="PUMA/OVT1_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055167">
        <property type="entry name" value="Rootletin-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24423">
        <property type="entry name" value="OVT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24627">
        <property type="entry name" value="PUMA_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15035">
        <property type="entry name" value="Rootletin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rootletin-like coiled-coil" evidence="4">
        <location>
            <begin position="167"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PUMA/OVT1 coiled-coil region" evidence="5">
        <location>
            <begin position="508"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="939"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1224"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2008"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="240"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1457"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2023"/>
            <end position="2032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10728.t1"/>
        </source>
    </evidence>
    <sequence length="2095" mass="244272" checksum="D1CF2A438B70DD60" modified="2023-02-22" version="1">MDDILPSMIADAFRGTFYQPATAMRPLSAAKKLQIVEHRGDQHGTSSAPANLTGEKREKSCVVGQPRSHPLEPGFWLPLGEGSLIKALSAEEIDRYLKGNSAERKQEEAEEVRKMAHKLSGMEEDHRRTPEEKPQEYFIDDEFSDFESSMTGRARLGRTQEDLNKYKQRIDSNAENQKEYSEIIAAMQNKLLEYRRHIADLQLATNVPDTSLFPQGDSGFLGDTTTDWGGRYARDANYNYDTILTRLDEERQRHEELRSQLDSERTHSDRLQGDLVHLQRQFEQEIQEKEHQFRNREKNLAQYLSDEQKKVLDLWTELQRVRKQFSDLKEQTEQELLEQRQEFNKIVRSLRSLVEGSEGTGRTAVNTDSMLIEIIRQIKDRGSGDAGNKLVPDLDLLNKFRGGGEATFGPELYNELVKKYEEAIERNIALEAGGDENARRVGELEADLRKTREKLAECQKAIRKMHELSSRGHGDETRSRSLSPGSAPLVSPPEAVRGVRNALRNRDNEIQQLEHRLRGNGRQIEELGTKLSQNEEARRRLEKELNGAKRESSEMQRQWDDAERIRSRFEEKLKTMQNERTLAETTQNNLENEIRRLKQELEKVISEGKRKAREEADDYAASMELDYKNRIDELNRRIATLLDEKQRLKNELTPLRAAVKDSENEIKALKRHLEEKALQHQSDEEQKKRLTYEVGNFKERLEALNAKLEKSRNVNDQTTKTINALEQNVQDLKQQRDEQSKQREEVQNKLNGAIDALRAEQTDKENLRKKGDALSTETERLKGELNELERQLIIARKHADELDAQLKINQARQATLENELSASRKETESINELNQQLQRERQDVQNANQELENQLAQLQEQMRKNEQKMETMRNEINDLRASEAKASEEANTQQNRSDHLNNMLKEAETRIKQMEEKMELLENEYKDKLKKTPWKGAKSIATTSTDGGGTTTIISDGEEERGVGAPEQEMYDSELVERKIREINGKWKLEVEKLENEKEPLERSLRELEEKLAEMDRGGQRIKDELEDTKRRLQAEIDRLKGEITNLHDKHQTGLEEERNEHKKNLTALNRETEELEDKQRQAERRLADALNAQSEFERNERELRERLDAFSMQNQKLKDAMEDTKMESEKEIQKWKTDAYSMRSELKALETTTTNLKTQLNSANDRNDVLNKTINDHVSKIRELTANTRKLEEDLSDARANNNVKEVEVENLQNRLRQLEDQNQQITTENGHLKNELERKLAESESVSTARNELAENVERLKKRLEEYEESFKEQRRAVAFLKSDNIRVQSALKNTNKQADEWEKMANQFEDKLEKLRTEHQTTMDKLIAAESDRANLRNKISSLQKELDFGKEQMLRRNEEYDAAIESMSNAHRAAEDGRLASLQELESKKYEVANLESRLENVEQRMQQLQQDYIRVDNQHELLSEILKRFQTAIGRAMTDRDRFAAELNGKDSSQLESFLKDLTNRIEILQRERNQLHEELNRLRQNSSDTKNTFTKRETHLKSIEETLESAEDEKRSLEARLATAKQLLRSQEETLKQREEERRQLKAGLMTTELETRGKEAQLRHLNEQLKNLRSDLETAREELRITRDRTESQEGDRYQLEGRMRDQEQELQKIRMQFVNSQTDNQNLNEKVHEMKGQLKLSDEKSSDLRDDVIRLKRDLKKAEDVESELRRSLDAQIKENTELQTMKDQVLRMQSDLQESQARKNVLEIEISNARVELREFKNRAQSLNSRILELQRQVQDTMDAKNRNEERLHDLEKQMSGNRITENEQKQQLEVLRTEKKQLKNELAEVREKLQQMKTERETVGRAEEQCKRDRAALLRKIEMYETEKRKTEAAIRETALQREAIEKSLNAMERENRELYKNCAQLQQQVAQLEVENGHRLVEITNRHREEQEKHVIRIRAEKAQIEKTLENREKLCKQKIRQLEQQIQLLREQLEAERRRSREFRDRQVASDAGRAFGMSRIIGTSPSGIGHSSLENYWPIRNDNIDSVGFRPFRSTYASNPLTPPRDASTPLATTGAAQRQETEKAKAQSEVPLSTALLSRAHGFDQGSSSAYPPFPGREPPTADEERESAEMARLKYSPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS49</accession>
    <name>A0A914GS49_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BPL/LPL catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GS49"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10266.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10266.t1"/>
        <property type="gene ID" value="Gr19_v10_g10266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="60"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10266.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39125" checksum="E03A35013ACAC09F" modified="2023-02-22" version="1">MGDETPCTEGRSTRLAWAFEMPSENSLVSLPVECRKRHQTNVRQWNESSALFFYRMETIGDNGDSLLIWRNSPAVVIGRYQNPWLESDVHFCQANGIRLARRHSGGGAVYHDEGNLNISLLTTHEGHSRKRNLQILAHFLNAELLCRPSDDVGIGTSRLIANSRDDLLIGKPPNGGAKVSGTAARIARGRAYHHFTLLVDVGMDALRHSLNSPFKNRIETNASRSVPAKSVGNLAQHIKRGTNHLVSTEELVEKVTDCVLRAFILQYESSKLVRWGGEMDKLRGFDEILTNLRSNEWVYGKTPKFTLQLMDNGGAICVENNGQICESSSGQFPIGTPFHKAFLSFSSECFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GST2</accession>
    <name>A0A914GST2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GST2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10427.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10427.t1"/>
        <property type="gene ID" value="Gr19_v10_g10427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF6">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10427.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36120" checksum="4D23B1B0EC609849" modified="2023-02-22" version="1">MPSDRDFSHDDDITNAANGDNKDNTKRKDICRDYLNNICSRGNRCKFFHPEESIEKSQNSADEPYQFCIDFQNQGCHRDNCRYVHAFREDVDRYKRSGDVTLGLARALAALLKGETINGIPLCKEFQNGHCARSSQCRYWHINRDEERRKRFAGRSCGGSPSSPAFGAYPAGPSAGAHLSRRRGDEFVNDDFSPPSKRTFSQPYATPGLLPPMSAAAPAPTHLIIELERRNGELTNEVESLKRELNREKERYDDLMSLFRAFQGQQPIQRPMVSASTLASNSLQPNISSLGGLQQQPQSLQQWGAASSSQPNWGKFDWNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSY8</accession>
    <name>A0A914GSY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10470.t3">
        <property type="protein sequence ID" value="Gr19_v10_g10470.t3"/>
        <property type="gene ID" value="Gr19_v10_g10470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="3">
        <location>
            <begin position="559"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10470.t3"/>
        </source>
    </evidence>
    <sequence length="736" mass="82003" checksum="6C8413A6FCDD452A" modified="2023-02-22" version="1">MGRPGSSVGKSIGSGCEADHCTEVFGAPTFRPRACDTSPTRHFAKLKKHLPFFLSFGEIGDVVVHSPLSSEKILSPKMAEATMGSSSSILQDLLRDHSSEIGNWSEIVNNHQDETATAESFSADIDHDGPFYIFATNLPIDSACDNDNANMEMYRFFGGHKHLYAVHVYQNRFHGAPQSCMLMARNFECCVQILMMDGKATDSKEVRLEYVLPSTDPPKTVHFTALKLEEQLLSYRNIHPLEEKRRPDPFGGAKPIDAAGKLQSVEKKLREESIEQRQKAEQPEHQNVRILEKTVSEEVQINRSIGPDLHKKPISKPVVPLRPCSDHQKNENPIHSILTKKVASRSNLSGCSKRHSPEKSSSVAARENTSVQTPEKCSSVSAPEKFSSIAAGENAFDLPQEKSSSDIAPEKSYAKSASVAASDKSSAPVKSSSLSATSKPFSATAVNNGHQQQQSKSEELVKQLASGKSGKKKPNKGGKKKKQEKNTIANTNKFDALLDKKGDCEHTLAVGFRGYETDSFGHYGLFLGTGRRLSSRRCQSDQGGRRARPLQRPDHPKNVMALACLFLAGKVEETPKKCRDILTIGQKHFYDQFTLDETPEDLMLAERILLQTLRFDLHVEHPYTFLIQYAKGFRFDKDYMSKIVTDAWTFLNDSLGTTLCLLWEPEVLAISMLYMSFKLERAVEKPFQIDSNIEWWNIYVQNLSVSLMDDICHKVLDAIGPPEENHIDEAIALEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTB6</accession>
    <name>A0A914GTB6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g1056.t4">
        <property type="protein sequence ID" value="Gr19_v10_g1056.t4"/>
        <property type="gene ID" value="Gr19_v10_g1056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1777"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1936"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1479"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1492"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1586"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1617"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1628"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1708"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1789"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1831"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1940"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1958"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1988"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2018"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2035"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2053"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2081"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2111"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2146"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2195"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2217"/>
            <end position="2226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1056.t4"/>
        </source>
    </evidence>
    <sequence length="2252" mass="249399" checksum="6071E1828D99ED66" modified="2023-02-22" version="1">MARIHVGYKWIFFDVLIVVTYCWWFSAVVVAQQQTQQLYQQPFTGYLGGEFEPNAWNSQYIQPVGNRQRSQTNAAIQQQNAAGNGQQQLRGFGSELKDVAQVANNNLKRVASRTGSKIKNAFSTHDDGGPNKTPFGTDSWQTSRVQTASNPSDPWKRVGSTQETPIKGHLKREGEPGSTTDQVGVQRKNEFSLNSMKVEDRSNFDQIGPIETVEDPKDNIENGTNSDQKKSKSTDGPSSEDAMSKKPSLNAASIDQKELKTEKSDVTDPPKALTNDSNRHDFIANKPQKVEDEAPKLIEEESTESNGPSKGQPTKKGSFDASESLKRANIGSKVSDGSSTDSKMEADTLRMAKPGPLGLGTSSTDDSKAANNAPIDSDGPKKEEQNFEHVKYSAKNEPPNSKDSDAEAEHIATNSNSASTVKQNAVESETNPKRVELKGTDETYVEAPLKERANDSVSDKERPNDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSVSDKERANDSVSDKERANDSNDLVSDKERANDSNDLVSDKERANDSVSDKERANDSNDLVSDKERANDSNDSVADKERPNDSNDSVSDKERANDSVLDKERANDSNDSVSDKERPNDSNDSVSDKERANDSNDSVSDKERPNDSKDSVSDKERANDSVSDKERANDSNDSVSDKERANDSNDSVSDKERPNDSNDSVSDKERANDSNDSVSDKERPNDSKDSVSDKERANDSVSDKERANDSNGSVSDKERPNDSKDSVSDKERANDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSNDSVSGKERANDSVSDKERANDSNDLVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSVPDKERANDSVLDKERANDSKDEDGSNQDKNGLKGFEASSKELDELKTDPTDGLKPNNVKKVTKDFSKNQSDSVDVEGEPKLKHKAGSKSHSRDSSTDQMDAKDGSEDRPDQDEAKDSVIDHKNVENRSKPDQDEAKDSVIDHKNVENRSKPDQDKAKDSVIDHKNVENRSKPDQDEATDSVIDHKNVENRSKPDQDEAKDSVIDHKNVENRSKPDQDEAKDSVIDHKNVENRSKPDQDEAKDSVIDHKNVENRSKPDQDEAKDSVIDHKNVENRSKPDQDEAKDSVIDHKNVEDSIKLDTAKVKKQKTAGDTDQKDLNLNTEKDSESNSNENSSKDKKNAAVNGQKQSNNNFSWQSDQSSGSSSSGSGSRSSSSSSGNESGSSSAGRSNSVNDDNGKIAEASAPSKNSNSAGRGSQAVSESVAAAAPGGTHEVRHGQIKDQSTREREASKPFKDKHEHLKNFGNEVKDVARSAGHNMKGAASKAGSLLKRTFSKNDRSDGQQIPQGESETFDDKRTLSQSERTDEQQVPQGVSGTAGDGRSISKSDSQGVSGSEHDRTLSKSDREDDRILSSDREDERTRSKSNREDDRTLSKSDREDERTPSKKDREDDRTLSKSDRMDVHQVPQGVSGTAEDERILSKSVQPDEKKGWKSVKDGSVREATRIGSNAAKIARGASRKASNLYHNVKDSDRTASLKQKVANNANRVGSKMGQLSRSASRRASSLFHNVKDSDRTASLKRKVANNANRVGSKMGQLSRSASRRASSVDLHENESKSGGLKKGAQSAWNKAKRGYSRANGYLREKARRHSANNETPRPHSTGANDKKKEEIDTHSFWKHFWATHPIQKIQDQNLVVDNERNNYSNIKSDDGSIEKENSKSNSSEEYEKKLEKSRQKSEQKITEKPKNNRQQFVSDENDDETSESDEETKKRRPGRKLGFNPGKSEEDDDDDEEDDSSEQIDEMPKIAKKSEWKITKRDELSDEDDDEQINDQMEEESLAQKEILAQKLEPKSKEDKKNDEKEADRNSKTDKQSVQISDKNRQDDKNKLEAAKKDGQNIKDKGQNDKNNGQIAKNKEPDDKKDGQKVKSANANVNSKVREEIKKKAQPKQKSSATNETPNRRNPPKTKKLRTPKRPRQRQSPSPVRRRPHHYHPRIVYASYSDYPVYRGAYVDDVAFNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTX1</accession>
    <name>A0A914GTX1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major antigen</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g10728.t5">
        <property type="protein sequence ID" value="Gr19_v10_g10728.t5"/>
        <property type="gene ID" value="Gr19_v10_g10728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057531">
        <property type="entry name" value="PUMA/OVT1_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055167">
        <property type="entry name" value="Rootletin-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24423">
        <property type="entry name" value="OVT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24627">
        <property type="entry name" value="PUMA_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15035">
        <property type="entry name" value="Rootletin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rootletin-like coiled-coil" evidence="4">
        <location>
            <begin position="146"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PUMA/OVT1 coiled-coil region" evidence="5">
        <location>
            <begin position="487"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="918"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1987"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="219"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1436"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2002"/>
            <end position="2011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10728.t5"/>
        </source>
    </evidence>
    <sequence length="2074" mass="241723" checksum="7C8BE730289B3A4C" modified="2023-02-22" version="1">MDDILPSMIADAFRGTFYQPATAMRPLSAAKKLQIVEHRGDQHGTSSAPANLTGEKREKSCVVGQPRSHPLEPGFWLPLGEGSLIKALSAEEIDRYLKGNSAERKQEEAEEHTNYPGWKKTIVGRQKKNHKNISLMTNSEDLNKYKQRIDSNAENQKEYSEIIAAMQNKLLEYRRHIADLQLATNVPDTSLFPQGDSGFLGDTTTDWGGRYARDANYNYDTILTRLDEERQRHEELRSQLDSERTHSDRLQGDLVHLQRQFEQEIQEKEHQFRNREKNLAQYLSDEQKKVLDLWTELQRVRKQFSDLKEQTEQELLEQRQEFNKIVRSLRSLVEGSEGTGRTAVNTDSMLIEIIRQIKDRGSGDAGNKLVPDLDLLNKFRGGGEATFGPELYNELVKKYEEAIERNIALEAGGDENARRVGELEADLRKTREKLAECQKAIRKMHELSSRGHGDETRSRSLSPGSAPLVSPPEAVRGVRNALRNRDNEIQQLEHRLRGNGRQIEELGTKLSQNEEARRRLEKELNGAKRESSEMQRQWDDAERIRSRFEEKLKTMQNERTLAETTQNNLENEIRRLKQELEKVISEGKRKAREEADDYAASMELDYKNRIDELNRRIATLLDEKQRLKNELTPLRAAVKDSENEIKALKRHLEEKALQHQSDEEQKKRLTYEVGNFKERLEALNAKLEKSRNVNDQTTKTINALEQNVQDLKQQRDEQSKQREEVQNKLNGAIDALRAEQTDKENLRKKGDALSTETERLKGELNELERQLIIARKHADELDAQLKINQARQATLENELSASRKETESINELNQQLQRERQDVQNANQELENQLAQLQEQMRKNEQKMETMRNEINDLRASEAKASEEANTQQNRSDHLNNMLKEAETRIKQMEEKMELLENEYKDKLKKTPWKGAKSIATTSTDGGGTTTIISDGEEERGVGAPEQEMYDSELVERKIREINGKWKLEVEKLENEKEPLERSLRELEEKLAEMDRGGQRIKDELEDTKRRLQAEIDRLKGEITNLHDKHQTGLEEERNEHKKNLTALNRETEELEDKQRQAERRLADALNAQSEFERNERELRERLDAFSMQNQKLKDAMEDTKMESEKEIQKWKTDAYSMRSELKALETTTTNLKTQLNSANDRNDVLNKTINDHVSKIRELTANTRKLEEDLSDARANNNVKEVEVENLQNRLRQLEDQNQQITTENGHLKNELERKLAESESVSTARNELAENVERLKKRLEEYEESFKEQRRAVAFLKSDNIRVQSALKNTNKQADEWEKMANQFEDKLEKLRTEHQTTMDKLIAAESDRANLRNKISSLQKELDFGKEQMLRRNEEYDAAIESMSNAHRAAEDGRLASLQELESKKYEVANLESRLENVEQRMQQLQQDYIRVDNQHELLSEILKRFQTAIGRAMTDRDRFAAELNGKDSSQLESFLKDLTNRIEILQRERNQLHEELNRLRQNSSDTKNTFTKRETHLKSIEETLESAEDEKRSLEARLATAKQLLRSQEETLKQREEERRQLKAGLMTTELETRGKEAQLRHLNEQLKNLRSDLETAREELRITRDRTESQEGDRYQLEGRMRDQEQELQKIRMQFVNSQTDNQNLNEKVHEMKGQLKLSDEKSSDLRDDVIRLKRDLKKAEDVESELRRSLDAQIKENTELQTMKDQVLRMQSDLQESQARKNVLEIEISNARVELREFKNRAQSLNSRILELQRQVQDTMDAKNRNEERLHDLEKQMSGNRITENEQKQQLEVLRTEKKQLKNELAEVREKLQQMKTERETVGRAEEQCKRDRAALLRKIEMYETEKRKTEAAIRETALQREAIEKSLNAMERENRELYKNCAQLQQQVAQLEVENGHRLVEITNRHREEQEKHVIRIRAEKAQIEKTLENREKLCKQKIRQLEQQIQLLREQLEAERRRSREFRDRQVASDAGRAFGMSRIIGTSPSGIGHSSLENYWPIRNDNIDSVGFRPFRSTYASNPLTPPRDASTPLATTGAAQRQETEKAKAQSEVPLSTALLSRAHGFDQGSSSAYPPFPGREPPTADEERESAEMARLKYSPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTY4</accession>
    <name>A0A914GTY4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTY4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11187.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11187.t1"/>
        <property type="gene ID" value="Gr19_v10_g11187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="8">
        <location>
            <begin position="99"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="10">
        <location>
            <begin position="299"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="7">
        <location>
            <begin position="500"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11187.t1"/>
        </source>
    </evidence>
    <sequence length="627" mass="69701" checksum="FA661BF5FDE80187" modified="2023-02-22" version="1">MPSTLRSPFAALPGYARVESLANGDHAMQCNLCYRANDLPEDFAWDPQTKTFGDPSRRPELQETTIEYIAPAEYMLRPPQPPIYLFIFDVSSAAVDCGQDQALIGFLGFDSALHFFQFDDAEGEPRHIIEFDVEESFAPVFSGLFVELSIFKESIRNFVSRIPTIFERSLSSSNCLGSALTVAKNLIHEIGGRITVLTASMPNIGIGALKCPEPSSAKVRNVTLAPQIDFYKSLALECTGKQIAIDLFVVGCQIVDLLTLADMSRFSSGTVFHFPDGLAPLFYSETRARGCVEDTLLERTFSSHILCPDSAMGVQIKHDEVISNSHVCFQAALLYTSTKGDRRIRVHTLCLPVLTHSTHVFSSLDVNASMSLLSKMASDRAMHGANLSDCREALINAVVDPLVCYQRSLGQVGPTLRMPPDGGLQYMPIYVLGLLKNKAFSEALQRVSSDERVATFLLYKNAPMEVILLELCPALYALHIFVEQNQHSCDLQNGQMPFPDRLPPSYEHISQSGIYLLDIGTLVFIYVGSASNVQTLYGLFGVGSFAKLDTDSTVTELDTPHSKYLHAFLRHLQEQRGNVYAPVKVIRDDNPRREMFASKLVQDRSDSSHSYNEFMQFLQREVNKANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVB6</accession>
    <name>A0A914GVB6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVB6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11519.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11519.t1"/>
        <property type="gene ID" value="Gr19_v10_g11519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11519.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40536" checksum="309BC1D84A691471" modified="2023-02-22" version="1">MSDNPKKVEKRLKEIFVCADVLFDVFKFCGPFVLGLKVALISDRFDFLMDAHFNLRGWSLGDLQIRRAINGNGAEIVKLIKCFDVERRLPIPQEPLPVNVIGFESLRINYVDRSVIEFLQRIRRLFDSNGINLSIRIYGARNPDWKIIWHRIWPLINENICSSFLCSFDYERLRQFSPTILGDCPKLRVIFSCYVFPAFPADDSAGASLAQAVAKWLHTPRGDGQPKVLECRFRLEEMEALKMAFVNSTDPVNFIIYFWNPSSDIVPFETRNNLTGEQLVFRHFKNNYWLFVRCPIERDEDKWAKWEAEAIEYKSFDSCNRISIYSGDSDIGRMFDANEGPSEPKKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWW1</accession>
    <name>A0A914GWW1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g12092.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12092.t1"/>
        <property type="gene ID" value="Gr19_v10_g12092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="318"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="782"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1318"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12092.t1"/>
        </source>
    </evidence>
    <sequence length="1341" mass="152026" checksum="10ABEE4A27E843AF" modified="2023-02-22" version="1">MTTPIIQTRVNPQIRKHDEMSRLLESRNVSFGSTLLEPKKSPGKAGEKGMMKLITNAHLLNLLGKQTIYHYEVTINGVSSRSDRKLRLSEPNGPRDRDDFPLLNRRDKCRDVFMAFNQTMERSLRESGNLLYYDLSKTIFTLKKLELQGEVKYVFNIGTVPSVERPDAARFKHYEFIIKPAMGLEIGDLSFVCNDMAKMDRSLEQFLDIATSQSVNLDNQRFIEFSSSRIYLLAPTEYGFDTRECPIFEANHSFLGIGPNKGCRIIEGEQGLGQMTPSIVIQAKKSAFHVPDMSVLEKAKIFLPREDTGIETGDITHHDHELICTGLTGIYAEPRYGPSGRFFRIDAVTKPNGGGGQNAENTYINHQISGNITIQRYFREQYHKELQFPKAPLLVSQRRMGEPAYYPMELCYVLDGQRVKGEQSANREMIGVTAVAPTVLKVHNERVKDALHLVNNDYLTKASVRFENAPLHVDFRVIGPPSIAYRDNATLRPDPMGEWKPTPRTNYLLNAKINRWVAYAFAPREGDSVRRSGFNEDCWNNFVAKYASEMRSRGIECPEPSAIYLHWGNAASDVMNILRKEADNHAEFALIGHAKGSEGDDVHAGIKVFEQQTEVVTQAVSFDLVDEIMNKGKHLPITNCIHKTNMKMGGLNYALLMDDPLVSQLFDGQTLFLGFAMNYPGGFAPTEIGNIHPNGGNGNGKLGSNGNVNVGNGSNGNSKAIGAGQQGRSFGALPPPSCIGWAATIGRNHKDEYIGDFVYQAPRREEKIDVVASVVKRCVERFKQNKKAFPKRIIVLRNGCAEGQFEYILKFEIPLVKKELEELCCDAKLTVLVPNKLQDVRFVRQDAKADEKNPEQNIRPGTVVDTVVVHPKRTEFFLNSHVAIKGTARTPHYTLLRDENDLSMDTLQAMVHSLCFGHQVVTKPTSLPSPVYIADEYAKRGRNIYAHYSKHGLDNSKSLEKIVKDKKFSWPLRNYDDMTKVLSFVATQYLKDLRSNNLSRKDSNSKAFKVKCEPGGFERFAGWKRSNPAKANRNTHVNERKFKKLRGSKRLILELDEDYDERRQIEMMRPDDLRMYMLRKGKPNAFKDVSAMDWNEHQTTLNTFGQTMDAYIPPETSWLARGAKEIVGDLKAKAIRAYHGTFYGIRKIRKKEGFQNFNVKQFIKLAEEVYINAYNALTIRDKQKLHRLITEAAFAKLWPDVEKGTLCWKLVEFNEPSKVVSVRCVDNPAKSGNDIAQIIVRMHSTQILALYDKDGHLLLGSEKEPRDCLEYVVFENHVASIDGLWRLHDRVYPKWLKPKQASTREGLIEEADREKLPDRPVKLHVGMGDKMKEARERSGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX72</accession>
    <name>A0A914GX72_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endonuclease III homolog</fullName>
            <ecNumber evidence="13">3.2.2.-</ecNumber>
            <ecNumber evidence="13">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="13">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NTH1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="13"/>
    <dbReference type="EC" id="4.2.99.18" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914GX72"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12182.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12182.t1"/>
        <property type="gene ID" value="Gr19_v10_g12182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="69"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12182.t1"/>
        </source>
    </evidence>
    <sequence length="608" mass="69261" checksum="E25CE271AC500349" modified="2023-02-22" version="1">MQKRTKTAAELEIEDCPSYNDLIETHIKLIRQMREKVSAPVDTMGCHMLADGKADPKTNRFQTLVALMLSSQTKDQITAEAMERLKKEGCTVENFITMTEKRLEDLLKPVGFYRRKAQYLKRVALILRDEYGGDIPNTFESLCSLPGVGPKMSNLALQIAFGKVEGIAVDTHVHRIANRLKWVNTNTPEQTEQSLKELLPKSEWGAINKLLVGFGQTICLPVHPKCDECISQKLCPWIDLLICLTTWPNTNRVQICPRNSNKMSGPETSDDRVAEDQAKKTDLSSKYAQWERLAKEWEIPEEGESGGVDSMFKKIYRDATDEVEKSGLKDLWALIDPIWKFEKEELVNYMAKRVVFESEDIIAFDKPFQLAVSSGPKDQAQLDRIFQLLKERIAPGIDRLYTVSPLDKSCTGVMIFAKSRLKQLELKALLAEDKFLFRFRCLCKNIPEEDKARISIPLIKVLKGSNMKLCPLIGTASRYEKVYHLNTDFKLVNECKPVHCSVVDAFVRRSLAHLVRSHLYYGLNCPIVGDQKYTKAHKASNPVLPMALSPNAMTALSLRKNDLRKMPMFMHCAVVHVPETKSQKMVLIRSEMPSFFVHALKRLRLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY68</accession>
    <name>A0A914GY68_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY68"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12238.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12238.t1"/>
        <property type="gene ID" value="Gr19_v10_g12238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="615"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12238.t1"/>
        </source>
    </evidence>
    <sequence length="814" mass="92513" checksum="9AA6B2717E48BFA6" modified="2023-02-22" version="1">MEPQQHSGINWWKSRTDAFNSKMKQDKRTENDKEIEFLGMTPSSHREDVVHGSANACISNHSPFSAAVPISFQQQNSKSAVVAQRLAEAERHVLSLRRQLKQQQRQEAQMARRNAELYKKSDGQEMESAKQLNNNGGCQFWISMGRAGDVHFVLFWSSELEKDDQLLVPFSKVKGQRISPPKRTKVQLQLCMFNEDVATFVFMNPAHSQEQLFAERDLVKEMLQQALVRHRQLVNQMAQQSAKGGTDREREAKQHILQQNTHLWDMYKHLVASKVITPQDFWSFHYKTDDKDTNGTDANGEQQRVGVSAGFLSSIVQSEGINGIRLNLTTETIQAIFRTYPAAFRSNFSPWLHRCQAVVGTTTPNGCWRRRQRRTRNDDGLAKRQRGQRQHKMETCKGMVNTNKSVHRRPRTMYSTWKATNLRSWTLSGTISASWPLTMCPNILPRRRSGSSAPCEARQRQVRQHAEANAIMRDAWEEGSTFDDDERLIELLDNNNLHGNEITLKNICDLHRKIAGNTYWAGKFRECNVSVGDFLIPTGPAEVPGKMRDLVVWINEQDKLNRQGQGMGIIWLATHAMHKLNCKCAWNPEQCANRQIQYGVRQPSRTKIASCANGKCVGVFDSALIETGRFVVEYVGEVIGEEEARTASDWHGGCARAQLLFTIREFIRGECRSTLVDARHKGNISWFINHSCEPNLALPVVRLGRQCPSLSMFASRDIQTAGWLAPSGMGKSCRTATASWPVRMLHCPEKPVCAVRPPAWDCFRQRPQFDACHHAGPDGIAEPETDRVQTHDSSGDDQITFSEFLLSARKFLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY92</accession>
    <name>A0A914GY92_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY92"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11890.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11890.t1"/>
        <property type="gene ID" value="Gr19_v10_g11890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11890.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23707" checksum="F2844A1D0C362666" modified="2023-02-22" version="1">MILLLTQHHHLQQQQQLQREFVSMNFDDVNEDCANGTLSRTYSAWSIVYRQAAAEIGSSICSTSINIWYGQIVRYVVCNPGTVRAVDQAQKLINDLLAICLEMLCTRTKFFSMESQRTIIQIVLVPLIEKGAVDKMWRTSSKCRKRLPQAKSHFPSNNNIEQLIDYQQPNQGVLVLIKLFSAMEQLLFANAELQRHFMNATTRAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYD1</accession>
    <name>A0A914GYD1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="Gr19_v10_g12287.t2"/>
        <property type="gene ID" value="Gr19_v10_g12287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="123"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="123"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12287.t2"/>
        </source>
    </evidence>
    <sequence length="292" mass="35198" checksum="B4DF97C6B961FF34" modified="2023-02-22" version="1">MYKGYENKKWLCKKFGRLLIGAEARFFALTEFPVGFHPATTRHNLLHFLRRINWRGKSLSEDEKQNYSKRAKKIGDELRDNFEKLTNEEKKDLWDKHIEKRNKLQRLQMKKKLQKFHSETNRPKQPLSSYMLFMKERFEKQTEPIKTQDKEKKFVAETGQQWRQMTDAEKKPYVDQAQNNIAAYHKEMAEWKRKYANEIRAWKEAEAKAARKVRDTQFMGALFELNIDEVDEKEAIQQMLLDDSTHLVEKRERSSDDYRDVDEEEEAIQRMFIAISTYLGRKEISQKQRVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZW9</accession>
    <name>A0A914GZW9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZW9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12338.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12338.t1"/>
        <property type="gene ID" value="Gr19_v10_g12338"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00182">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF181">
        <property type="entry name" value="OPTOMOTOR-BLIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="123"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="T-box" evidence="6">
        <location>
            <begin position="128"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12338.t1"/>
        </source>
    </evidence>
    <sequence length="423" mass="46902" checksum="D8FA2C63F0D5B423" modified="2023-02-22" version="1">MSQQLPTSHSHLQSSQHFLQLHHPMLFPYYCPVPPQLSPSSSSNTASSTTTVDADSSTSSSSGAATPITHQQPLVHQLGNANVPCQPQQLPRLVSTSKNSGAFAPPSAECITSVDNKNVNIELANKELWEKFHRVTNEMVVTRTGRKMFPKLELNLRGLDPNGLYSLTLCMRQLDTLRYKYQAGGWSPAGQDDSSATVSKFVNHHDAWNRGEFWMSQEKLCFDRVKLTNREMESNALISLCSMHKYQPVVHLYVMNEQEGKAVRVCLFEPPATQFIAVTAYQSEAITRLKVEHNPFAKGFREGSSRKRTLSPSPISERNAPNDFPEGCPSVKRPLLCPSALFASPSAVPSFPMHPLYGSISTWHPWSAFLAASMAASSMSNGTSTSGYQQNSQMTELGKVYSRFWQQQQQQTSRSNGGGKDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1J2</accession>
    <name>A0A914H1J2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dep-1 fifth Fn3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1J2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12806.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12806.t2"/>
        <property type="gene ID" value="Gr19_v10_g12806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056966">
        <property type="entry name" value="Fn3_Dep-1_5th"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24940">
        <property type="entry name" value="Fn3_Dep-1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dep-1 fifth Fn3-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12806.t2"/>
        </source>
    </evidence>
    <sequence length="93" mass="10200" checksum="565E50EB45467FBA" modified="2023-02-22" version="1">MLGAALSAWSGPRVSGRDSHLHFSIQPLEADSADQQQQVETGPTEPEPVLIDGVREGACYKVLLYTVTSSGIVSEQRFEQFKHVRSAKIGQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1R4</accession>
    <name>A0A914H1R4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1R4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13343.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13343.t1"/>
        <property type="gene ID" value="Gr19_v10_g13343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="287"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="310"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13343.t1"/>
        </source>
    </evidence>
    <sequence length="368" mass="39841" checksum="5E6686E027293843" modified="2023-02-22" version="1">MVNYLADLVALGDVEKRAMDILPRAARGYYESGADDEQTLRENREAFRNFLIRPFALTDVSLLDTSVSIRFCSTAANPKCRPFSRTFVYPIGIAPTAFHRMAHDEGEIATVKAAGGRVSPGGEHSVVSAVYLQRSDADRANRAEKAGFSALVLTVDAPLFGRRRADERNAFQLPDHLKIANFASHEEQSTTFGADVGSSGLAQYVLSLFDSSLNWGHLRWLIQFTELPVLVKGIVRADDALKALEAGAAGIIVSNHGGRQLDHCVSTIEALPEVVGAVKGKIPVFVDGGFRCGTDVFKALALGADLVFIGRPIIHGLAVGGKDGVKHVLRLIRTELDYAMKLSGCPSIDQIRSAKDLVVRKSHFSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2I4</accession>
    <name>A0A914H2I4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2I4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1307.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1307.t1"/>
        <property type="gene ID" value="Gr19_v10_g1307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1307.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8072" checksum="AC7F38885A9CF31B" modified="2023-02-22" version="1">MNVSAQIAEKALGKATGETPGSGRSPRAPAPRVPARSPPPSARQISSSASVSPHYLPCSISACSLLADSYAAFHLVDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H461</accession>
    <name>A0A914H461_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914H461"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13091.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13091.t2"/>
        <property type="gene ID" value="Gr19_v10_g13091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036711589" description="ATP-dependent DNA helicase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="112"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13091.t2"/>
        </source>
    </evidence>
    <sequence length="557" mass="62809" checksum="29BDA8E029E7C148" modified="2023-02-22" version="1">MRWLFVSILVFGQPSNARELWDKYKEHMYHPHGIASKAQRLAKELQALADIDWRLFNFGFSCVHFGLPDPPNSIAKNTEKAVEEFFFGDDDLNVPPGLPNANQPQQSQTPPLNSDQQMVFDAVVKAIQTDPSDQSVPRRLFVYGDGGTGKTYLFGQIIRRLRKAPYSNKVLATASTGCAAILLPYGKTAHSTFRLGREVSLDKLPSIPLESFFARRIREAQLIIIDEITMLNNTVIEVIDRVCKEMAIRQHKELLFGGKTVIFSGDFKQSLPVVPHEGLAAQVAACFQTSPLFGQFTTMKLTINHRLGKGQQDYMKMCRQIGHGETGEFFWIPPQFLVQSSEDLIDFVYPDFQKLLGNDKELLNRLILAPHIQTCDEINELMMDNVPGQVRDYLSTDKPLDERPLDIDEIESEVAALNQRTDSGMPPHRLRLKNLVKKKITGRAINGTAVGGQVRFFIERTRNVYEDKAPGGLKYERLQFPIKPAFAMTILKGQGQTIRTVGIDLEREVFSHGQLYTAFSRASDGNNVRVYAPNRETDAQGRARVLNIVATNMLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7C4</accession>
    <name>A0A914H7C4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H7C4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g145.t1">
        <property type="protein sequence ID" value="Gr19_v10_g145.t1"/>
        <property type="gene ID" value="Gr19_v10_g145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g145.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25883" checksum="447A2F046443499C" modified="2023-02-22" version="1">MMDVLRIDTSSSIDRLGRIFADPFRREQQQQPDDEQQQQQDYFAYTPSAFAQRIDEMIGSQTRPWRRNVGDGSGGAAADSDIHLQMAIQSSFALPPMSREERMMASVMENCAFKSVMACALGAGIGVLFGLFTVSVDPSYAISKDPTKPLSLRETWTETKSRVGRYSRNFASIGFLFAGTECILETTRAKSDWKNGTFSGAIVGGLLGLRGGLQPAVLGAAGFAAFSTAIEFYMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7C9</accession>
    <name>A0A914H7C9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ran GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H7C9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14503.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14503.t1"/>
        <property type="gene ID" value="Gr19_v10_g14503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000142">
        <property type="entry name" value="Ran GTPase activating protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14503.t1"/>
        </source>
    </evidence>
    <sequence length="721" mass="77862" checksum="72BCE3988BBE28E3" modified="2023-02-22" version="1">MRFLTFAGLQLKMDNVYDGEKIAEKIRECPGLEVLEMRGNTLGVDATAPIAEALESQYNLKRALWSDLFTGRFKEEIPRTLKTLCDAMTLSGARLTELDLSDNAIGPMAVPGIKDFLAGEAAFALQTLKLNNCGLGIAGTTVAHCLLECHRRSAIQGTPLSLKTFIAGRNRLEYTSTAALAEAFKIIGTLEEIAMPQNGISAKGILKLSEAIRLNPALRYLNLGDNTFGESGANAMASALENLSELELVDFSDCLCRDRGSIRIAHSLVASKSPLRELNLSGNEITIEAAKKISRAMNDVTGIQLLKIGVNCFGSQFNDFLDFVQPIAFIDAGTESDDQGSLSDFDEFVNESSEKDIRSEVAVERDIVIDSAYYCSSLSFAGHQLKLNSMADGEKIAEKIRECPGLEVLEMRGNTLGVDATAPIAEALESQYNLKRALWSDLFTGRFKEEIPRTLKTLCDAMTLSGARLTELDLSDNAIGPMAVPGIKDFLAGEAAFALQTLKLNNCGLGIAGTTVAHCLLECHRRSAIQGTPLSLKTFIAGRNRLEYTSTAALAEAFKIIGTLEEIAMPQNGISAKGILKLSEAIRLNPALRYLNLGDNTFGESGANAMASALENLSELELVDFSDCLCRDRGSIRIAHSLVASKSPLRELNLSGNEITIEAAKKISRAMNDVTGIQLLKIGVNCFGSQFNDFLDFVQPIAFIDAGTESDDQGSLSDTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H819</accession>
    <name>A0A914H819_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H819"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14582.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14582.t2"/>
        <property type="gene ID" value="Gr19_v10_g14582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF310">
        <property type="entry name" value="UNCOORDINATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="438"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="569"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14582.t2"/>
        </source>
    </evidence>
    <sequence length="755" mass="85855" checksum="EA33EBC707AA14EA" modified="2023-02-22" version="1">MFFHSPLPRTPVLRRSTLSGHVEIGTALRQQLAEVFTPPSNNVYQVAVVQRESSTDDGGGAPSEAETVPLLEQQQQLLLMTDQDQLNNNIQPTAQQQHHQHQQQQQQPHFVAPSILVSSSSMEKSASAQDLAGTAAILRRHRSGSKVFPQQHTGSSVRAIVLRRPTITIQEDGRILIARRHCHLPKMDQPFMGGRRKLSAPSGATARKLSSNRKISRTDRVVREIFHTKVKDPPPSSPVEKLQQQQQQQLGGLPMLKHSSIPFNVSLHPFWPFMHLGDNITARWDGLPMPKQPTLLDGDDVGTLLTSQLNEEDEAKTGMNCPQKVLKFIKIMVPHVVLVAVLIGYLCIGAVILQALETRTELMVRSRKLVRLGQLIENFTESSWHLLVQQFAADGKMRREQWDGIFRDYMISVAAEVDDRRPIRQEMLAPEQLANIHNKWTFPTALLYVLTVLTTCGYSEVSVNTDLGKIFSVIFALVGIPLMFITAADIGKFLSDPILWLKKNWRRIIKKIKRMLIEFFCIHKIGTKYRRKSIQSMTASMGALDMLETMDQIEEPTNLWFPIGAYVLCICVYCSMGSFMFMNWEDKWSFIHSFHFGFNLIVTVGLGDVVVTDYIFLSLIVAFVIVGLAVVTMCVDLASTHLKAYFTSLHYFGRAKRFLGMSEELREIVTLLGVLRRKKHGKITWDDVCNFLENELYNRPFEPHDLLMKLRFIDENTLSSALSTVRHNSFQSDFLRDADYLRRLRALRPDQPAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8V1</accession>
    <name>A0A914H8V1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8V1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14309.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14309.t1"/>
        <property type="gene ID" value="Gr19_v10_g14309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14309.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17838" checksum="DCA1F81743E0C1F6" modified="2023-02-22" version="1">MALISDRFDGLVDAHFKSRKWSLGWSVIVRAIGGNSAQIVSERFDERLPIPQGPFPGKVISFKSIWISYVDKTVIEFLQRICRFCDNFLRRFFATAQNSDRSIPMDFFPRFRPKTAPALLPAKPWPNGCSPPAEMLFRRGFVVVILWQGWKDSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8W5</accession>
    <name>A0A914H8W5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8W5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14322.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14322.t1"/>
        <property type="gene ID" value="Gr19_v10_g14322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14322.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13222" checksum="F0C6A44ED808BE3B" modified="2023-02-22" version="1">MPYFPNQSQSTRRTGASNFFSPTPQSSNFTSGNTGSSSHYDGVMPYQQVPPMHDTFMPSQAGTHSLDWSGDNLQNNEGSLQSMVNPKNPRSSHYGSTMPFQQARKMPSKMGKSVRRKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9M1</accession>
    <name>A0A914H9M1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H9M1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1549.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1549.t1"/>
        <property type="gene ID" value="Gr19_v10_g1549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF41">
        <property type="entry name" value="MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="109"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1549.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25241" checksum="1CE81E6DE2773825" modified="2023-02-22" version="1">MNSGDPYWPFAVGGAFVFKSAGNDVSAQQPKLSSEAAEEKRRLSEGGKEDKNIRKTEQQQQQQQRNADGDGKGGHKRRKREKHQKKKFECTRYLRALSPPIRLRTQHNRRKPRVLFTSKQVTRLEECFDRQKYVSGTEREKLARELVLSPTQIKIWFQNRRYKCKRIDQDLNLHRMTAQFSSMQQQLISGGAGGHFSPTQQTQNDFGRVTFPRIFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9X9</accession>
    <name>A0A914H9X9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9X9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15404.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15404.t1"/>
        <property type="gene ID" value="Gr19_v10_g15404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037610490" evidence="1">
        <location>
            <begin position="31"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15404.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17690" checksum="7B65427A847049E8" modified="2023-02-22" version="1">MDLRLSFSLFSVCNVCLNVLWGAATALAAAADTQHQAGQTHRHRGHTATHQEEQNVLFLSLSPINPHTLSGTPHTRREARAATRQCACHVCGRQRCSACASRAHKFAPPHACVRVSLAAKIEPTVTLTGEGRNGGYTVATERRNSWRKMAPLDDTQRVGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB37</accession>
    <name>A0A914HB37_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Troponin T</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB37"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15885.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15885.t1"/>
        <property type="gene ID" value="Gr19_v10_g15885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF7">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15885.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18106" checksum="5A0B17F9F5B3CA29" modified="2023-02-22" version="1">MMAAKKRHEEEEAAKLLDFEQKRRQEKDQMDKELSELRERQLRRKEERKREEAEMAARRRQDEERRRKDEEERKAKAEVDKTKREEDKRKRQLMMAGAFVGGVGEGTPPGRNFVVNKSEGAGETGQKTESGGSILRKGTNKAQQEKAKVCELLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBK1</accession>
    <name>A0A914HBK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15092.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15092.t1"/>
        <property type="gene ID" value="Gr19_v10_g15092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15092.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8474" checksum="5B069AF462F58EFE" modified="2023-02-22" version="1">MKERLFQLNKHEQAAKLKKRLLQLGKHEQAAKAMFQLNKHEQAVKLKKRLLQLGKHEQAAKLKERLFQFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBN2</accession>
    <name>A0A914HBN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 209</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15589.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15589.t1"/>
        <property type="gene ID" value="Gr19_v10_g15589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019176">
        <property type="entry name" value="Cytochrome_B561-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21780">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21780:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09786">
        <property type="entry name" value="CytochromB561_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15589.t1"/>
        </source>
    </evidence>
    <sequence length="543" mass="61748" checksum="E6A4617D1B756628" modified="2023-02-22" version="1">MGSSAIIHKLADSHLLRHSAFWFLAAFFMILELSIFNGYLLWRVSNKILPLSFIYVLELTLFCLALANAFFYLGTHLTSMYSNMKAKLFVGSIRSSTDMDTSVGSVDSAKMEHLNALCTFMGNFFKRPATLPNQQNSTSLLSSTFSEMDASSLSSLVGYHDSPLNKTVSSVHSRSQLNYILENETCDSVIDPTDCAAYFNYNPPGTSRFYQAGTPQYLLQDEDTAVTGIRSFIDEHKLSKYARRPDKRLFQRTRGDASPKLHIVTELKEILEIYGLREQDMEMYEIKLRIWLCNTIIRPLVDKIDDINVDFAEKHQSLHLKVGSSSLETILAHKDVLSTTFVPFVLPYLRAHNNQQYVVSRMRTLCRNIALEQFKWNGGGEQCARDENDSFDRLVHWSEQLPTDTELIWHLFCTYMDFHITPSSEGVSSEFNKPFTNVFFANLADGKLPLALMRGNILQSKQQQQQQTPVELAEKFFIRMSSSRPPAFELIVDGGETIVLPCKDGPHNFWYVLILFLAHIAKMSQSRIGPIHLSSLSLNIFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC36</accession>
    <name>A0A914HC36_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15230.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15230.t1"/>
        <property type="gene ID" value="Gr19_v10_g15230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001:SF3">
        <property type="entry name" value="RIBOSOME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15230.t1"/>
        </source>
    </evidence>
    <sequence length="1262" mass="146695" checksum="5BF88FC035638059" modified="2023-02-22" version="1">MGPLREQLCPASPIPESAQKKPENDVIILDDDEEDRKPLVEKSGPSKRGRKPRWDKQQQEQEELPPRKIRANESEEKSQPNVFDYPTIFWKLARPKYGIFTFMCKDCQNANFLLGDRRFMLTPQNGEGRLEFTQTFCRDCAKLNFDCTDLIMKHQKRDAPTKNGHYHPYTGGNWATVGTLEKQYVIVHLRDGRKYRFRVPSGSFLSPQQLERGIHHGMISEMERLMTRKRAALVEEEGELFDLEVVEEEQGVEPPGEAPLLPLRNETATQERERAQKEQKERLAYEKENDRLRRLEEDRKEKERLQRVEEDRKEKDRLENERKAKRQKWLEDGRKETERQRLEAARKETERLQRIENAPKENERKEKERKENERKENERKENERKENERKENERKEKERKENERKENERKENERKENERKENELKESERVGKLKQESASQDKNKEQERMRRDQERQFKLRELELLKELKPYRGGWMRLVQGKDPTPDVHYLHEKDEYHFANAVDKYRIYHPELPWDLPAFNPSAQIQRNIAEFKGLFEREVYDENYGSKTREEKEELLVLVKGFRFYYMEDIGRFMLKIFDNKISHITLTDQLAYVLGYEQEQQILNEDLAKYSVDLRGGVSHLCIYLNSGIIESMIFGNTFANLLQVIAVEGKSGSVVEKDFQTPLFHKIIAREVDVLDVEIRTLTGREVPFDFGQVVLTLQFKKFYQQTGRGPIAYFEGLPTFQRGYGYFLGVPRQKGAGVGAVLRNLWRYLRPMISAAKPYAANIATELGKEGLETGARVLSQVSKGGDIKEALLAEGKEGAKKLLDKASSSLQKGRGKRKRRGKKTKAEIILKPFDVIHPITSYIDLSKVFVFTEFKIKKIAEDGLLNNIGSSDSVGLIQMPGATFIRNLKVHINQREVYDSNQLYSYKVYLDTELSYPIAAKDAYFGVAGYFRDTDLSKANDKRRKPLAESKAYQTISKLSADIFNQDLYMISNVEIDIELALQSDDFMLHQEKEKDKFVLEISDCRLIVKTVDLMDGLSLDIARKLDVEPARFGIRKSFMKSLFITGGRYDFSANLFTEEVPRRVIIGLVANQNYIGHKQKNPFFFNHHNVRDIELTASGRTYPQYPYNLDYKNNNYARAYHDAQEHLGLACTTESNGLSYSMFKTAFCLYVFQMTNSQEDSPGFELIKEGCTAGLQPLGFICSCERGGFGAKMDNRFIDKILFENPATRKFFMGTFPSDGLPGCSRFPCSLIVNLDRAGRPGSHCQSFLMFVAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCV4</accession>
    <name>A0A914HCV4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCV4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15946.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15946.t1"/>
        <property type="gene ID" value="Gr19_v10_g15946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF27">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE F54C8.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="107"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15946.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22886" checksum="132C0997D2C85135" modified="2023-02-22" version="1">MVRTSRKIPTDWTKYEPIGATIGGSRIFAFKTPLYPELQNRISKECRFTTLDLVQKLASFDRSLGLVINCNNTRRYFCKKDLEGLGIDYKEIACPGRGFLYRMDVVKLFLKSVDDFLEQNNDNDLLIGVNCSNGVNRSGYLICNYLISRLGWSSHDALNAFENARGYPIERGSYVQALHKADREHRSKMMPLELDKNDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD25</accession>
    <name>A0A914HD25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16387.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16387.t1"/>
        <property type="gene ID" value="Gr19_v10_g16387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037640947" evidence="3">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16387.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30528" checksum="2BAABB21BB9D8FAC" modified="2023-02-22" version="1">MAFFLCVLFFGTILRNGAAASSGNGHFAQQQLPGYFTYGGGPNDDTRRMDSESDQRRQQQLGRTSRRHSSDHFSQQRPQMSDNQQRKPGGWSFGEKDKCQERCELDCFTFPFTDMGDTIKEFEQPRLIWICTQLKPPSRPFHEKIVNHVTNASLFEYVIFGVVLMAVIVCFVCGCYQCCCRQNPHDGRHSSRSFIEERNTDCSNFANHFGAQTKSNHAPLKLVTGSFIRRPFRPPIAHIRRRSQRSVGHLIRSERWRAFECHGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDB4</accession>
    <name>A0A914HDB4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDB4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15977.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15977.t1"/>
        <property type="gene ID" value="Gr19_v10_g15977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15977.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7955" checksum="34FC938765A1F73D" modified="2023-02-22" version="1">MPAEVPLLSILALSRQRANWRAGKPGRPLPRRNANKRRVSDALNLGFKQVGPEMPPMFWTCWRTLASDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HER1</accession>
    <name>A0A914HER1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease Z</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HER1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16462.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16462.t2"/>
        <property type="gene ID" value="Gr19_v10_g16462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16462.t2"/>
        </source>
    </evidence>
    <sequence length="101" mass="11703" checksum="17E3546C15A2D474" modified="2023-02-22" version="1">MKFPTIAFASPFSKKICAIHQSSTRNLFVHYSLPTFSAQHLTKEQTRPSSSAIQNKLSEKLKQSQEELENYKPDSTKYRLIKLRIANLREGRNFPSWNSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HET8</accession>
    <name>A0A914HET8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HET8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16858.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16858.t2"/>
        <property type="gene ID" value="Gr19_v10_g16858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16858.t2"/>
        </source>
    </evidence>
    <sequence length="448" mass="50842" checksum="23680EB880F37FCD" modified="2023-02-22" version="1">MLILVRPICQASQYQSATRIAFATTRLSTDRIQRVAEPMPPGRGKGLWSNCWEIIYWCVCPSLNASYPAVVERAHGLLQFFAFTALSDANLTHGKCNLSAINAWFALKQTPKNALRTLRDLHPNWQMRRFKIGIGNKNESLAFSNTALFLLIASMASQFGLSICAQPSSVFMCPRGPMAAPKNTSDRYNGHSRSRPTDGRVFKKADSSCRRGLYSSSYSSPPIQNGRTLTSSQPLYSTPHYVSSTHLQPLSHGTAHSTSRLSRYMTPSPRQLIRTLLVQPPRRLVRVSNCHRPRAVSRCSGDRRRRHFRMPPTAASIGHNSRHCWPKWKASGGKPMTSDPKMARRRFRAARNSVRSIRRRCAFCQEFYIQTSTRMALCVLALFRSPTEDTRQKTTCGGRRFIQWNRLSPANLGATLLFHGNPVKYNDIVRQCVKWSNDFFERDSLLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGA6</accession>
    <name>A0A914HGA6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HGA6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17103.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17103.t2"/>
        <property type="gene ID" value="Gr19_v10_g17103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="132"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17103.t2"/>
        </source>
    </evidence>
    <sequence length="330" mass="37915" checksum="6E7F93D02D602062" modified="2023-02-22" version="1">MGILICNSSVLNLDVVLCNGQSFRWTKDADGIGWIGIFCHRLWHIWRSNEHEICFKVLHKFAGNCCNENNEKTDANLLEEYFQLDVDLERLYGFWSSQDIHFAKLLTENREMLQGIRILRQDPVETLFAFICSANNNIPRISQMVEKLCQFYGDSVDSNSHRFYDFPTVAKMATHLPDMEHTLRTAGFGYRATSIVKTVEMLASGVLTINNSAEDWLRSIGDLSYREAKLSLMRLPGVGPKVADCICLMALNKHQVVPVDRHVFNITAQIYMPKFMKDRKTFSRAIYEKIGQQHNLLLFHRNVNFTLVYTAIMQDGPIPFCSARDFGDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGN6</accession>
    <name>A0A914HGN6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g16447.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16447.t1"/>
        <property type="gene ID" value="Gr19_v10_g16447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8206" evidence="3">
        <location>
            <begin position="1387"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1624"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1760"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1553"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1624"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1701"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1761"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1786"/>
            <end position="1804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16447.t1"/>
        </source>
    </evidence>
    <sequence length="1813" mass="204150" checksum="CF6BCBDD3F107E17" modified="2023-02-22" version="1">MSTSSPNSTDSDLTADKVHVSPPFVWPITEMADELAELAQRQRPDSPTPTESGYDLVSNVGGQNDEDGTQIGNHGTQIGTDPVAATLQHDKISEHQQHPTTIGRPTGKKKCLALLQVERKDKLTVCLKYEFFMTETEQFFASGDEHCEPTVSHMMQTLLPKHFAMSMEELTEKFDLQLQHLDIEFVPPEFIDIDPREWCAELVKDRGKYKVLLQPKLDNNSASRIVDAGKVVPENVGVSGRRCDDVPMGGQQNANKEAGRRLNDGDVPMKGQQKANKEAGRRLNEGDVPMKGQQKANKEAGRRLNDGDVPMKGQQKANKEAGRRLNEGDVPMKGQQKANKEAGRRLNDGDVPMKGQQKANKEAGRRLNDGDVPMKGQQKANKEAERRLDDGPVSGQRNANREGGRCLEDEDVPMGEQQNAGYDWEPIDRSLLSGKAHLGNLYNMLLDNFITSNDHGFLRKKYNMHSPTEQSLATHGNEIIEIDHLDRLEERTKMLGTEQKLSVMSRLARLDDVCPLGQFLWAASQQGGQNNSFGIIQISPKMTISLKLDAPEVRNSVMQQNPPKDATHFVGSTCFGSLVAAIVTFDQQTFGMEKFVKMAKKLAQKHIRGYPMTPPEIDTLNSLNSSVRVSVFVDPSIGSGGTDLEFLHGLDVFVESTKKIGFSQRLGHPISFSLIPLYAIDGDKLPTSITPIEDYGLVERIQSCAQSLEQFELEFRTTDQSLNEHAFILNVHQFDEIKRTFEQFEEDKAEIDDMLKNCVINLRVGQDAEEADRSTGELERAVGQFMGEGRELLGQCDRMLEPRMELLRELDSKGVQYIGRGNRQLADVLLGNGCSSTNASSTLHFVILYSESRTSQPVAVGGLSSQHEGKRFYRQCLGQLYQMAERGKSCIFVDLDVLETTACEGLPQGILALDGFPNIGSRLIKMRGHKLLTADCVTEEAEKLQICIARIENSQRTQVGAVPPKKTEPCSLPCPCCQGYGGKCQNNDLLWGCDDCGQTLAFVKEENAPITHFYCACGATPAEEFSFRCNDVDAHGKEFEHFAKTQLTNELERLKSKGILTILLLGETGVGKSTLINAIVNYLKHPTFEEALQADEIESVIPARFCTEEYDDDGELVQKEVLIGKMSEAECLKPGQSQTKWPKAYITPSKVGYKIRLIDAPGICDTGGIKVDNLNLHKTLSFISTLPELHAICILLKPNSTRTGTAFKYCINGLLTYLHKNAANNIFFMVTNSRGSNYKMGKTRESLREILNPIEDAHQVSIRLKQDRIYCLDNEAFEHLCLIKKANVQYTQKQMDNFSESWTQAEQELQRMLKNMSPPLEPHRIWETVSLNKAHRTIVDLTYPLASISQKIQDNLLRIKEHQEAINKGEQELNTGPTFDTVQFVPLDHPRTVCTSARCTEVKKTAGQEIKLYRRHCHAHCFLENIQPENMPNESLTNCWAFQGQDKCQVKECRCDWSVHMHYRFDQVVVTNELDEAKRKLFADKRGTVSTLEACRLQMLHEREKIYSKAALFCSFLKIWALKPYNDSMEEYILLSIQDGERFVAESDGEADRKLQMEKLEGLRESLRLYKEQKELIDNANASNSTGTNAIKADDVTECFEELCKLPIFGPSIKQMYEVQQKTRKDNEKKYKEEEAGTGFMPKPCRNRMPGNRVEQYLNDLEQQSLLNSYAKKQRENELFMEQQRIEQQKQWQQQQYYAQSHSSNANPWKGTSSVKTGYGANTSQMASGSDGFRQQSESTSSDSFWQRIPVVSSVYNFVRPSSAQPPQQQQFESFSSDSSSTSRSNNNRYNGRAPSNGNQNQSRFGRRPMERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGU9</accession>
    <name>A0A914HGU9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GYF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGU9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17370.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17370.t1"/>
        <property type="gene ID" value="Gr19_v10_g17370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17370.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37289" checksum="26E4CF621A91F45E" modified="2023-02-22" version="1">MGDRSKKWFYIGRQDDCEHGPYTSKEMLLWLRCHYFDESLRLRTENDSRFYTLSDWIQACGNKVPFEMDGPSMEQPKNYGSAQLTENMHMDPFLQRPPTNPASTANPLVGGTVDSERQQQVQLGVPIQLLTASQKAPSTAQQVLLMNTQPSPNQPLVIPVSSVPTYQFVQQHAYPSMSQQQPLMPIRLQAQSMLPHQIQQRFIGDTEQSQQDGTTIVSDSPDSGHVMTPSSYPINQICNGLEVMELTQQRSERILLDTMDGSWKRGMVMNGMVKMVDNWTNMEDDTHCQQSKGTQTEDIMIKISQADAERLLFQLLGIRLRINFASEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHM4</accession>
    <name>A0A914HHM4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17242.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17242.t1"/>
        <property type="gene ID" value="Gr19_v10_g17242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17242.t1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43851" checksum="56FA1E92A6090B75" modified="2023-02-22" version="1">MADKRMKLKPGTCVANRWTIVKKLGSGAFGAVYLCTDPLGEEAALKTEAVSTSRRFLRMEASIMRKLANLQETEGKKHFCRCLDLGHDEQQDKKTKLQTKFNYIVMSLVGRGLDRLVPKATGRFSPGTAIGVSIQMLEAIKALHKIGYVHRDIKPDNTAIGRTKDNEKRLLYLIDFGMAHRLITNGYHRHERSKVEFRGTLQYAPASTHMNRDYGRKDDVESWFYVLIELYRGSLPWDILKRSRQIGDAKCRRVKKDVPEHIRKQAAADLLDGCPKDFAKILEHIDGLQFYDEPDYALIISILRNHLTASGIQEHPYDWEKASAIEDQPSSSGDEGATSAWDVGDRSKDKGRAKESTWELKRSIAGSESDETSPHGSETDEEYARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ25</accession>
    <name>A0A914HJ25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1920.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1920.t1"/>
        <property type="gene ID" value="Gr19_v10_g1920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1920.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43353" checksum="17508AF26D9978FA" modified="2023-02-22" version="1">MIFGGPAGAAASTSAAEAVHGHAPHIFDQLRVRLDRSGSNLVKPNAVNAVRHVDYDGSIQKTLVMTIPMLLYNFNMSDPRQKTLVMTIPMLLYNFNMSDPRQKTLVMTIPMLLYNFNILIRNCPQELLKGFIKNGRHGQLHSQPSSSAWATTAKRVCCLLSMKRCQPSQNPPSFNLQKHQNAMQTSKSTSASAKCQQQLQLPRELIYELILCVPSTDWHARRVLLTCSFIYQTILNSKKTQNWKQPVPIMQLPLLPRIHGVSLLTFSQQIVPNMARYFNIIDGTIRSFYCIIKLDHALFPPGQSQSRLRLSLHSAITAHNFLGPTVEVFYLSNPVESEYDVLRLNFPVELPLEYIGGILIVALYKLGEAMFMAARGEFMHLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ91</accession>
    <name>A0A914HJ91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1821.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1821.t2"/>
        <property type="gene ID" value="Gr19_v10_g1821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038138468" evidence="1">
        <location>
            <begin position="22"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1821.t2"/>
        </source>
    </evidence>
    <sequence length="341" mass="38202" checksum="ABF0FE777B1A17F3" modified="2023-02-22" version="1">MNYFIILLILLSITFQCFLKAKILHKTDEKDVAHIGHHHLLEGPQLLIHQLSSAIHSHYKAAQELKTLRDLLKKGFDRRATFRDDDPSGDVNSLLSVLAKISSGCSCNASITVMQKTIDTSFSALIGSEHLLCAALSDQSAFKTEECVFVTKLLFKNSLNVTVELISEDLLCETSTDNCEKNRGALGKNQVISCKFCEMLHAKAFKEMAECLECKAKKEGKYQFKLSDGSISSLIGHLRKVGCQVPESRRNRKFRCEEQWKYDATNCAAHLLDRSVKNSFGSKQGAISELFANCRRIVSRVKHSIKALDELKEVQELEGNGCSLELFFDNDQTFVGTEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJX7</accession>
    <name>A0A914HJX7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DM13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJX7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2167.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2167.t1"/>
        <property type="gene ID" value="Gr19_v10_g2167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037067480" evidence="4">
        <location>
            <begin position="24"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="5">
        <location>
            <begin position="80"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="5">
        <location>
            <begin position="207"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2167.t1"/>
        </source>
    </evidence>
    <sequence length="585" mass="66537" checksum="481BEBB8EB56D799" modified="2023-02-22" version="1">MPILGHFYVIIFAIFLLVHQCIGVPFSDPSTLASSPSNAHHVESSSSNNHHQHHHHGHNLNSINDSPNKWVPNVYTTTFGTYIGPMRAHALDTTTTAAQPPRDIGHLFAVNETVVQCVNCTFAGDVADTFFWLDHSEVPTRDGVRLPTYEFGLSPLGQIRPTKAVLLVLPDNGQRISQYRSLSLYTLNGDVSLGSVRIPENLVVPRSQLLPDELRGNRYDVQSGPIQILDTRTIKIYGFIFQGDKAPDGYFYVGRGLNVSRETGVKASIRGRDTSEMISPMNERYTGGKDIFVELPEGYDVHHIDWLSVYCVRFEVDYGHIFIRNISPMIPPYVSSPIRFDDELIAHQGDKWSMNNLLGMASQLNFTFQLGPPGGKRGYKTMLNVARPPKYVWYVNGYIAELYLKRGVTYTFIIEGGHNETVAELYNPFYLTDSFYGGYAKLSNDEKQKVRKFTQEEIGRLCRWTETKMDVHPDEFATFVDFRDTLTLECDDSEQASIITFTPDRETPDTLYFASYFNYQMGGRIHIVEEFPANLKHIIAEPYRYDARRHQESLELSRDNSAKRTLMALHFVLLATFTYIFFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLC5</accession>
    <name>A0A914HLC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2395.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2395.t1"/>
        <property type="gene ID" value="Gr19_v10_g2395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2395.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25913" checksum="9B24C48216527FDA" modified="2023-02-22" version="1">MFYFFNLFPNFWWGKETKKSFCRHIKRFWSPSEEIKPVEVPDVEVDAFKAMLAFIYADDLSGLNGDNAISVLYAANKYNLPELVNSCLNFLWKLNVFFAFDEARFFGKKSSSLHRAPRVPSIHSMLRNLQAIGQAALKTCLHPVHLEVVGQLQQTYTQAYNNKTVAQHYCFNDFKNGSDRIEMASRNSMNCSIFMPRLPKKRIAARHLIVFIIYGRILMIMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM14</accession>
    <name>A0A914HM14_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM14"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2375.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2375.t2"/>
        <property type="gene ID" value="Gr19_v10_g2375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="174"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2375.t2"/>
        </source>
    </evidence>
    <sequence length="457" mass="51336" checksum="BFBE00B87B0A6F61" modified="2023-02-22" version="1">MSISTGLTPELTHEEAMEILWTFYFHKEPAEQMRLLRARIAELERRQRANSPTLSATSFDFVTHGNELNEDDNLDTENEIEENNNDDGSNAADEDDGGLATPDELAFQANVAELEQEQQQEPIDQTHRQHNNQNELCAQIAELRKLVAELTVAQKEQVSVEQFSQVQVKLDELEQRQKNDQMELNRKMNGLIPQNRWDPLACHKDLSLFWSNGLIIEHNGQCFNGDRFYFDDRCTGYSARSVLAKWPIPKNHFGIFYYEVAIISKDVHDVFVGLATKQMALDGCVGQYKGTYAYGSCGIFAGHNAIEDGRRHRTDYYNVPNAAFGPAKSPMGWMMPWQDHYGGGGFPCAYGSNGTFSGNGTFSGDGTFSGHNAWRQLFARRAYSEGKAKFAKGDVVGCGVNLATRQIIYTKNGQRLDTANLFVDSFDLFPCVTLLFPGAKIEANFGPNFKFNVALEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM93</accession>
    <name>A0A914HM93_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HM93"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2090.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2090.t1"/>
        <property type="gene ID" value="Gr19_v10_g2090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037999707" description="glucuronosyltransferase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2090.t1"/>
        </source>
    </evidence>
    <sequence length="536" mass="61316" checksum="2E83B58A0245F684" modified="2023-02-22" version="1">MLLYQLLIIFAIFQLRPINSFPTTKNDSTPPKLRILILTSRVIITESHYVLHRKMAELLAADAKNVEKVLLLVSHDKCPDTNEEPPEFGGRLLVWFRMTLSTAGVDCQTAVDQWTEFARMSWPIWEFNETTFLPNPQKPSTANLDFLTNHQKLIGQLQRHKFNVGIMETTVGDLSLSLFRQFPTIKKFVSSQSTVPAIALWKIFGYDKIVGAMPGRDLARIGDHKFATENAIKQNPNYFLERNVNLFIKPTERAGKLLQQKFLEAIDHGILPRNNFEDLIRHEDFSEWDLKHRTALYFSNIQPFLDFPIVEKEIERERNNTHQNRVNFIGGITLSKGKVPNLNPDTKQIFESAKGGVVLLSFGSAVEMDDGDERAVSVKNIVVDVFKQYPLMNLIIKWGKRPPTGTVEQYNKLSENVYAKSWLEQEAILGGGLKLFITHGGLNSINEAVKFGVPIILFPFFGDQYNNAEALAAREVAKVLDIRSKTLKKDFAEALDEMFNKYSSYKQRMNELSKKMNSVEPGKEFVEKFRQLRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPP8</accession>
    <name>A0A914HPP8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IBB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3081.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3081.t1"/>
        <property type="gene ID" value="Gr19_v10_g3081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3081.t1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43341" checksum="78C463CDB8B175BE" modified="2023-02-22" version="1">MADRQTQFKNIGKDMEALRNNRTEQVVSIRKEKQDDIMFKRRNIQANDANENTSTSNAAGGVAVVYDGSKLEFSSGLNMCIDDLISSGILPIFVNCLQSANDGLTRHWAKRPETRAAMRAEIVVKPGGRAAEELVYGASPGHYSDMDSWEAKAKKIVKTSAEWCALTAGQRTRNKLARRAERIIARAFRVARGILTRRQPLLHGHAEWHALEPGQRTRHELTRRVERVIRRAYRVAGAILTQRQRLLHKGTESLGHHQSRNKNKKINLIGVNALSEGQDDEREDSEFDTSGDEVQNNAPVKNTLQKVTCVASATSDVLTTHWAKRPETTVVNLGGRAAEEHIYGLSLGHYSDMAQWNTKAKKALTVCLFGSAVDLFPCVYVGHAWHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPU7</accession>
    <name>A0A914HPU7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3119.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3119.t1"/>
        <property type="gene ID" value="Gr19_v10_g3119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3119.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22084" checksum="22202F9F74C16E74" modified="2023-02-22" version="1">MEQNWCSGKSAWNRIGVLESQHGPELVFWKVSMEQNWCSGKLYQNLLFQKASWTRIGVLESQHGTELVFWKVSMEQNWCSGKSAWNRIGVLESQHGTELVFWKVSMDQNWCSGKSAWNRIGVLESQHGPELVFWKVSMEQNWCSGKSAWNRIGVLESQHGPELVFWKVSMEQNWCSGKSAWTRIRLSEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPY6</accession>
    <name>A0A914HPY6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g3565.t3">
        <property type="protein sequence ID" value="Gr19_v10_g3565.t3"/>
        <property type="gene ID" value="Gr19_v10_g3565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="773"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="990"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="1089"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="870"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1336"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1442"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1546"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="872"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="921"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1372"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1569"/>
            <end position="1578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3565.t3"/>
        </source>
    </evidence>
    <sequence length="1640" mass="178564" checksum="F71F93E6519E73A4" modified="2023-02-22" version="1">MRPLRAQLDIGNHLLLNCSIIHSTSSQLQTKMPSFMCMPFLACNRQVDSLDRRQCNLQSIPGDIERYARSLEELLLDMNHIHDLPKSLFRLQKLQRLGLSDNDIHRLPSEVAALQNLMELNLSRNDISDLPEDLKICHNLQVLDISSNPIARLPDSITLCTSLTQLALNDISLTKLPHDLGRLAALKTLEARENHLRALPPSVAELSQLQRLDLGQNELDELPAEVGALRALVELYVDENSLERLPDAMLRCTRLEQLDASSNKLFQLPDELGELVALVDITVSHNCLRELPSSLGRLKQLMILKADDNTIDILTPAIGGCTGLTELYLQQNLIAELPSSIGNLKALQTLNLDRCQLRRLPALLGECASLTVLSVRDNQLHELPMEVGKLARLRVMDVCNNRLAHLPYTINVLQDLQALWLSENQSQALLRLQQDIDPRSGIKVLTCYLLPQRDASVAAASNDGVPSGTNLVANQQSKAAFVGGPKVHFGGDGEEGANDGTTAAEDGAEMGATFEFKRKNTPHPKNTTSGQGTKLKQYQQQQHKHKGDKVDGHVAPRVEEHPPSIVLSGKKVSHDHSSSLLAPAEQQPSTSGSTADQLRSALKYSSRAIQQQQQQHQTEAAHPPPTAQQRYPPSGSTSQPKTVLFTGAKPAPQTNQAECKLKRVNTPHYKSTRGTTGDGSSGSGSTRTSAPAVTAAQNQFQPAGGISSRRQLPQASSSLPAAAATVAQDGMHVQMEHHQRMQQHHNPSNNNNTDAVKVQLLAATALNAVERMRVNVRRAGADGDGGGGGGLGLSIAGGIESTPFVEDDPGLFISKLAPGGAAERAGICVGDKVLDINGTPMVGQRHHVAVQCIQQSSDVVELLLERRRTTTEHPPFSSSSSAFTAPAPPLAVSSASSSSLHQTVRFSPPAPQHHRPQLGLSSSASANIASHHASASSTTTSPSMTTTTIHHPNTLFPSALTTPAVLQQQQLPSVSEHPFGDPQLDDIVEEVELVRDSRNSLGLSIVGGIDHCSHPFGTPALPGVFISRIAPNSSAHVTRRLRVGDRILKVCSRDISGARHNDAVEALKNTGRTLSITVRHERQPTGLRVVVVPRRDTQPLGLSICGGIGSAPMNPQDRTDEGIFIERVEHDGPAEQCVGNGKPLTVGTRILEVNDESLLGCAKEEAAHIFRTTQPGPRPHRPYRLGRPPQCCCHPETFVQSRNSSCLLRQMPMLTQHIHLLQITTVTKPATTHSSAIDNEKMEQQQHQKKNNKKEQIGNEYQNLSAGHNGRYAVGLIPKNDAKTLVGREMSASVALLDIGTMEEQQQKKMEVTTFSSEPYHNNQQLNKNNNSICEQQQKKVAAPPPPVAPKPKTNFKSFAVTGGSKQQQHNVHGEGTDEKSNGTAPEASADFSSRLRLFQHEPSQNQTSSATLLPWAAPSMKLKRPLLSSDDLAKLAEDDRMRTKAALQPPVENGRRAGSDDTGEEPSQQIGMMLSPMSPFVDGGAFEHILNDSPVPFVPSSIGSIRTKKAENRFLQTNAALVLSSSPSPTISQVVLEQQRRQEWRQARMASLEADNRQQDPPPPPPVGSNSSKSPALNDNHRTRTNSMERTTRPDANFSILFRKAFLYTSLSSILLHFQYLLNTRFCAKFSPFYINQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQD4</accession>
    <name>A0A914HQD4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L50, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQD4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2736.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2736.t1"/>
        <property type="gene ID" value="Gr19_v10_g2736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542">
        <property type="entry name" value="39A RIBOSOMAL PROTEIN L50, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036860286" description="Large ribosomal subunit protein mL50" evidence="8">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2736.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30321" checksum="4FF6C28A34F49E76" modified="2023-02-22" version="1">MSVNESCSFLHSILLHCCGCIWLESAGLIAYGNPGKISPNEIFKAIGCGRSSSTTASASTLEMDKIRARGFLKYTYNYSPSPDVEQKIESAARQCGVELNPADWRTTELTDLEKKEKLLLNIGKQCSHFVPNSKLHKMKTIADVTHFYETPTSNITKYAAMARSSGDQMPKNLSIMEHHRRFHPNDKSAPHGGITAFPGELGKVLGLRNQRLYREYKPKKHWYEFEDVVFDYDVTCTKGMPWDPEVAKRMDSYTDVKFVKDHLIKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQE6</accession>
    <name>A0A914HQE6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peripheral plasma membrane protein CASK</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQE6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3486.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3486.t1"/>
        <property type="gene ID" value="Gr19_v10_g3486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10831">
        <property type="entry name" value="PDZ_CASK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000146">
        <property type="entry name" value="MAGUK p55 subfamily member 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="251"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="338"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="6">
        <location>
            <begin position="547"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3486.t1"/>
        </source>
    </evidence>
    <sequence length="734" mass="80412" checksum="429BC7960D1D5D1B" modified="2023-02-22" version="1">MRKLDPATDLLRRRNREQSLMLAYASHLPSLVMLQLLEQLDGSGDAERMALRTLHARLSVQRTSLYDRIRTESVRPAPVNRAAERALREARKELQQSVAGTSSAAAASELLELLDNVHLQAILQSMDVTAEEVFTPTAMCTPATTPAASNEATNFMTGQLEAFELAGGGIASTSSDAVPNSIPNGAVCTGSAHAIRPQQQNRLPSSMLRPTKNATLAEADEEYCSDAAAASGPLPGDDDDLVLSAINRVRLVQFSKDTEEPMGITLKITEDGRCYVGRIMHGGLIHRQATLHVDDEILEINGVSVANRNVEQLQRLLRDARGAVTFKIVPSYRSAPPACEIFCRAQFDYDPAQDDLIPCASAGVPFQTGDILQVISKDDHNWWQARFVCPFPALGGSSKWSSSSAGGRCSTTATSGASGTICGAANAVASTSAAALANHTGGGGAPQKHPKRRPPFATSSSTLTATTATATANMAGLIPSPELQEWRTACLAMERARENSHCFMFSKKKSGSSKYYTTKYLRKHSELFDGMEMISYEEVIRLATFRRKTLVLLGAHGVGRRHIKNTLIRLHPHRFAYPIPHTTRPPRRDEIDGKHYYFVPNDAMLADIQANEYLEYGTHEECLYGTKLETIRAIHRTGKMAILDVEPQALKVLRNAEYAPFVVFIGAPDLHGLQDPDGSLERLVKESELLRQSFGHLFDVVLINNDIDDTIRQLESVVEKLSAIPQWVPVSWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQH5</accession>
    <name>A0A914HQH5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQH5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2959.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2959.t2"/>
        <property type="gene ID" value="Gr19_v10_g2959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022:SF1">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00917">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="4">
        <location>
            <begin position="235"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="381"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="654"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="609"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2959.t2"/>
        </source>
    </evidence>
    <sequence length="844" mass="96957" checksum="44C58F99DD97E066" modified="2023-02-22" version="1">MPGRGSCSAVDYNCSHWAHEFFYKVHRMNFFSNSASMFLEERNFFWREPTPTRVTLTIGIGLRCLGDETGRDTMEPAKSECPSNTGGDQTDDNEYKRSDQIVYRVPNFKAFYEGRGPKEVLSNPFEYINGLPWQIKIRHCDAHVGFSLYCYGDATDMAWTFRAAFQCGVVPCKEIFERLKQREYRQINANENYRDWQRLIKFDELMDPKNGFYDEKEDVVTFIAEVIPEKLNGMAGQVVFRMPKFKAFSKGGWPKDVLSDAVEYINGLPWRIMITRLGDGYAGFYLRCDGDKTDMTWTCRASVKFSVVSSCKEIGEYHTIRHREWRRIYNAIENPWGVQKFIKFKELMDPKNGFYDEKADAVTFKAEVIAEEPNGMPGVRLKDALRVNGELVNVNKYLLAAHSKFFQNMFFGQKAEEMPKCGIIGMKKKILKEMPKKDFSMFEINKLGAEAVKELKSNEFGRSTVLTGKINTNKDIEKGFSDLSTLINGGHITTDPENCATFVNFDSSEEVRLFSEQHRNRLGMNGKIGKIENFVAILNPNKWLRCDPYRIVGSILIFIFITYAIHRMNEQKENTAALIEAQKKNGLLPQQNRSNESEEQLNDILEQFVAEQNKKFEEQKEINKMLQKQMDELGNSSKKELEKKEQQQNIDDLQKTVAVLNDTINGKRLIRQQNRWDSAACHENLALIEPGRLVVKFTRKNYGWRSVLAERPIPKGNFGIFYYEVKILGGARGVYIGLATKQMPLADNWVGELEDTYAYESGKFWAHAHAIDGKPKFVEGDVIGCGVNLATRQIIYTKNGERLDTANLFANSAADLFPCVSLFYPLETIEANFGPNFKYNAFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQP6</accession>
    <name>A0A914HQP6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAC3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQP6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g337.t1">
        <property type="protein sequence ID" value="Gr19_v10_g337.t1"/>
        <property type="gene ID" value="Gr19_v10_g337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="233"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="717"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g337.t1"/>
        </source>
    </evidence>
    <sequence length="823" mass="95728" checksum="C77952E03AE948F6" modified="2023-02-22" version="1">MENVVKKRPNKPINSVLQKRQKRLHSGGDGFELLPKLKATSTKQDIINGLKELVGRTCATNADKFHLLQRRDVLLYKLRDIYSGAGANRQMSQGTCPDMCPEKERYMRDAKKTVHFYEFNAQGQMVHEKMVKDYSRSAADQDTPLAHELRPLKTLHITMDYLIFNIANEIPSTSNSDLARWYDFLWSRTRAIRKDITQQMLNNEMAVDLVEKCARLHIFASFRLVELEAELFDHKMNTENLSKSLQTLRHMYDDLAKKQIFCANEPEFRAYDILLNLSDFNVHSQVLSYRAVVRDDPKVQLALSLSSALQNNNYIRFFRLVQSQSAFLQACLSHHFFPMIRSNALKVICMAYNIFPIDAFAEYLAFDSMDEALKFLHQFNLEMDVTDSNLINVREGRNFFAPGGEAPSADALQRTSCQWIKRKAQHLNLSQVLFNNPLAVRPDHLRDVPSPVDSFSRDSGAYVKDPVLKQFVELDGVAIATTRKNVRVEAPPNFSFARALQPFQTTFQPLRPIDTNNNDPSLSLRENLIDNVVLSRLSIIAEITLENSIRKNLRIRKAIRQWIFFVTKKRKQKIVNAFSSGMIGHIVSQQLQLCANNVFCAFRSDFRRRTALEIAVSQADFLLDKIVPKLLYSIGGRTRANKVRHTSERLQNIRENLQREWLRQFSDHWLSVVRRNRILRNITFLTSPGNTATILTLSPSQRLFRPNAKKVTPEQMREMAAEKMRKMEEERKSKKLRQIRENLQREWLRQFTDHWLSVVRRNRILRKITFLANPPVTETLSPPSQRLFRPNNVKTATLERMKEMAAEKMKKLEEERKRMRGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQV6</accession>
    <name>A0A914HQV6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g381.t3">
        <property type="protein sequence ID" value="Gr19_v10_g381.t3"/>
        <property type="gene ID" value="Gr19_v10_g381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="415"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="822"/>
            <end position="1279"/>
        </location>
    </feature>
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        <location>
            <begin position="1344"/>
            <end position="1364"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1399"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1475"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1594"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1743"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="1974"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="2088"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2294"/>
            <end position="2380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2485"/>
            <end position="2539"/>
        </location>
    </feature>
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        <location>
            <begin position="2196"/>
            <end position="2223"/>
        </location>
    </feature>
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        <location>
            <begin position="2400"/>
            <end position="2427"/>
        </location>
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            <begin position="541"/>
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        <location>
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        <location>
            <begin position="630"/>
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    </feature>
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        <location>
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            <begin position="681"/>
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    </feature>
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        <location>
            <begin position="761"/>
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        <location>
            <begin position="840"/>
            <end position="849"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="871"/>
            <end position="900"/>
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    </feature>
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        <location>
            <begin position="921"/>
            <end position="958"/>
        </location>
    </feature>
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        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1059"/>
        </location>
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        <location>
            <begin position="1062"/>
            <end position="1077"/>
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    </feature>
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        <location>
            <begin position="1087"/>
            <end position="1102"/>
        </location>
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        <location>
            <begin position="1126"/>
            <end position="1150"/>
        </location>
    </feature>
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        <location>
            <begin position="1151"/>
            <end position="1161"/>
        </location>
    </feature>
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        <location>
            <begin position="1242"/>
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        <location>
            <begin position="1345"/>
            <end position="1354"/>
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            <begin position="1399"/>
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        <location>
            <begin position="1499"/>
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        <location>
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        <location>
            <begin position="1614"/>
            <end position="1624"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="1974"/>
            <end position="1991"/>
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    </feature>
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            <begin position="2009"/>
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        <location>
            <begin position="2053"/>
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        <location>
            <begin position="2314"/>
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        <location>
            <begin position="2328"/>
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        <location>
            <begin position="2338"/>
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        <location>
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        <location>
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        <location>
            <begin position="2520"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
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    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g381.t3"/>
        </source>
    </evidence>
    <sequence length="3069" mass="336316" checksum="6DBCB31559D48531" modified="2023-02-22" version="1">MYTEILELVNFFARFFHLRIPRLKIGMFCEHFANNCFLRFHLYWNLNQPKQYEELRIIRVSHQYTDELFTSAASAVGLQLDELLSCIPERLIIVYVNPGEVFYCPGDYSPPVAVWVGPVCEDLKYNETCHVTFPPPPIPSSILPTHAIQPLIPRPTSNLPGAGCVNVTVDFSVLSWRIPLGLVHPRELGYATNPTSDFLMFRYCVPGTPNYTVETFASTRFGSYRKRPDYEFFTRLQHSLLLLNAQSSSDDIGRTFPLATFYRLVFFPLSPWALCPSLGFFPFGAREFLLLNISDRLIFDAKWVSSELGSKRRYNGLLEAEHHSEGSCQGFSMARRCDTTDRHLPQMSHLIFFLRPIYQLEHFRNVLAVLLGNKSKRTICNSEFKAAKAGMKEEALTGRRQHRDVQKHKFPGSNSELIPVYTKWANDLLQAADLPPLTDLSGELCMPLKLIVLIHSITFEFQKVPKEQLIALLSHNDALISIKQSLAYLCQIGVPLIDSIQAKDIRNGHLGAILQLLYQLSLYHCACQQQLHRQRPEEAPQQKQWPNRSIRPSSAGRTCYTTASSSTITPTNTRTNNNLPAEEKNQWENRTVETSASRKVAFKMPPDASLTSLEGANREGTERKGEEQEMASNVRLSRIASTHRSALRPPQISAAVSSKRSVARPQPIELLEAPKALGTNSSRLVPPSSQRSSSQSANTSPKGLLRGGGTDIIIDFVPPALPASKQLPPAAGFQTTNRICLPIPTVLTPEKKHSLCPEVTNRNSGRNSNGGLSDESKRTAPEGPNFVEASIVCNSSSQHDSSVSPTVHQQLQFQKSVLRQPTPSALAGRSKSALRVPISSIRSVNPTSDELNEHSPKQTGQSLPQHHHHSSSSSTSVPVLVSSSSSLPTSASSSLRTSQLRPPIVSKPVPPKRHTSTVIRSSEERLKEEPREGEATEMNRLRLFGGKDRERERKREKVSAPICIGPPSTEQHEAHQMPSYPPRGKDLPDQNGEINKLRKPTSTSKSLLMPPSSTVSRRVTATAGGGVQPTSGRAASQQLRSGETAKRGAGGRAGGGGGTTASQQMNTSQCSTSSNGGRKSGQLKKYSQTPPSLMTTSSSSSSVGIRITSKPASSNSKLTGIPSAKKTKEELSGNKTDSMTKEEETMRTEQQKCQAANSPPTTEKKPILAVKGISVPSGGTPSPAQKRPSLCGGRPSSADSASECPRSPLMSDSRRNPHMVVGVVSPMMHQQEEVLGGTSEANRSEERSVVDQQREKDNPSECEPSAIQKPPEEPIVVNSEMEKWNFPEQMLGLSDGSPPIHPEKVAKISKLAKAVPAKRLIIPTMASQILPEGTMEEQNIGGRKVPSEKCRGEECPSPSVPPSMAPTKLMSVLREEQASPCPSSSLSTPAEEETNRCYHFDKDHPNHRCQDGHSSQQHQKVSPDELISAAVATASDNSTDSVRTTIQIHCFSTKNDQLGELLGDCAIIGGGTAPATAEDNDGQQNLHKNGKGGIMGQKMDGEEGEGRRKMIDSNNGKQQLATEGAGKDAVGVISGGATSRNQHHYPDNPPMSGTADYASESELDFRRQPMARHLYSTSIPAGNKLVMALDLRPNSGTALRGGGRKSRFRESYEDSSSLSSGLSEPFDDDISTDDLTGSSSDYLLGQLSPNKMRQFAHENGQKHIDFVSFQKPNGPQPNSMVSAAERERQTAGQLLQKCKSAQRGCAYFGSAGGGGPIVDPHRPSTSNGYLPTPAVGHFVHNSAEGRRSGCDQHHRIEQSQHPQKPYQHHPNEQLFALREQGQQHRRQQQQQPEQQNQQQFDLFRPYHTITAVDWPPLQYQQQQQLSRTHRPVDARRLLSPPHNLMVLSDDGDTLSVAAGDVGERTTRGQSARPPGATLLGTQQQTMAATHLQNADLLHRRQHHQQHPAYHTHSLDRHAHLRVLSAGVRPLPAAADDHSPRQGQFANISRNLPHQRLQLNSLLISPRHHYSVNGYTSSTFAPPGNTNATSSSVHRRSRGGDLYGYSNGPLLPPQCFPPPPPPGSSARSSVASGTPHQRSASLSAMSRSMVTVLEQHEERQRRRGRGDGGETQRRVLEYVRGQLEALNSNARGDVIEAPPADKSAKSSHPPLPIPPQQRSSPHLNRRTPLSLPRQLELNNNHLHSAGSLSARGTDGRIYSNLKFPNSGVNSPTRLPIQQPGSQLSLASSIGSTYSTIEERYEWEIGKLQNELESYRTHVQLLSQKNSGFNCVIQMFDNRLQSIMLALGKLQQKQNVKRDEVERLCNEIEQLRALSVTAGVVPFSNMEGAACTLKSAGAKGDEQQQNGGGSNKKSWKTNVDTQIRSSFNRAFHKGTKKSKQQQQQLQPLKDTTDNTHSSFPSSFLNLANNNNSSSSSMTSKMDSTKRELETRELALTDVQLDALDKAKEIDILRETVNRLQHENKLLKYNFSLLERRVHSESRASSHLSLNTTCMAGPGLDFDAATLEEVLVEAPEQLAALYDLAASSPSSGDISVNTTTTGSSANGAQQFVPAELANKSTDRSSFASSTTSSKRSSRGPSTALPSAKVVLCVDLSGRLDSPHPLGHLMSLPPSNSLCSISRANSGSSSTLSSQASSSLGSVMSGAAMTSKTGGTARRELTVGYLPLPVGSATSWKDLDQKLGLLLEEYLHRIDPDLSLGIDSYSSIIGYQIHPTQQQSDTGGHSEIFLIRRRGSVSETGQQQQLVENCAELGELLPKLSPAEALQPGTLIRIRLKGVVQHSVDALVLESLFPRHLLEQLLYQLEQHRRLLLFGPTGIGKSNLARLLAKYLLMRLERNNNNNPNTSKALVDIRFPMDGEKHRQEGNQQQKVQQLIAALRPASNTAVLVMDNLQWKRLGTVLEAFNNSAAGEELLAGASVAADLPLSSPFVICTLNRTCVDHSPVQQLQLHHNFRLFALSYKMDAVNGYLGRYLRRRLAEQELSSYASLGPPALCPSPADPLESVLHFLGRSLRAVNEFIERAATGGPDLTLGPRVLLQCPLSSEEAQGWFVQLWNDKLVPYMRKVLTESKAFPIPAVDGDDKVSAFAKDPTDEIGTLWPWTGGKEQLLKICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR10</accession>
    <name>A0A914HR10_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR10"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g311.t1">
        <property type="protein sequence ID" value="Gr19_v10_g311.t1"/>
        <property type="gene ID" value="Gr19_v10_g311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g311.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20103" checksum="229728DF4A7249B4" modified="2023-02-22" version="1">MSELNLEQKVERLRLSLTEFRKEALWTVIKESPNQASTDFVRDLENLFAQPTPPAMPPQTMVTTSDGYVTLEAKLPTQFAETSSDDSQYCTICQGPYDDCEHLSCAFQRGLEKTPSTSKAGTTKGRAGTSVAGPSKTETSKAGEETTSAIGEAPRKRRKLKKSPMKLFCNKKEESSSPEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRM4</accession>
    <name>A0A914HRM4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3819.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3819.t1"/>
        <property type="gene ID" value="Gr19_v10_g3819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022:SF1">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="170"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3819.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38238" checksum="89F5E30AE1C6BBE5" modified="2023-02-22" version="1">MEPSKRQSPSNIDSEQTKDNKYKRRGQVVFRMPNFKEFSEGRGPKQVFSPRVEYINGLPWRIETVHCDEYVELYLLCCADKTDMAWSCRAAYQFSVVSCNKSGECLRHQGDLDDFALYYANSLSWGWRDFIKFKELMDPKNGFYDEEEDAVTFKAEIVAEEPYGMASVRPEDALLVNGELVNVNKNMLAAYSTFFRTLFFGENAEEMPKVQIDEVPDAVANFERLIATMDPLNIDLDDKCIENVLLLANRFLLGSVEKRCVAFLVTKSKKSAICKFRLAHQCGIIGMKQKILNKMSKEDFSISGLYADNMSELNKLGADAVAELKECHKKVFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS25</accession>
    <name>A0A914HS25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4136.t5">
        <property type="protein sequence ID" value="Gr19_v10_g4136.t5"/>
        <property type="gene ID" value="Gr19_v10_g4136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324">
        <property type="entry name" value="IL16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324:SF16">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4136.t5"/>
        </source>
    </evidence>
    <sequence length="180" mass="19336" checksum="F1AC1855442E244C" modified="2023-02-22" version="1">MAIGQNENATCGSRIQTLVLYRPPQSRQADFDANANGKRQRPTQCRPSAELGFTVVGGIDSPRGPMGIFVKTIFPHGIASRSGLLQKGDEVLSVGDVSLVGMTHAESLQTFRKMGKRAEVVICIRRGPKQLLEAKKGESLKDDSVGGHGQQRNGGDHLPIRMESSTFAGTSRLSHLNKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS50</accession>
    <name>A0A914HS50_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS50"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g373.t4">
        <property type="protein sequence ID" value="Gr19_v10_g373.t4"/>
        <property type="gene ID" value="Gr19_v10_g373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g373.t4"/>
        </source>
    </evidence>
    <sequence length="362" mass="39746" checksum="71183A6015EFF092" modified="2023-02-22" version="1">MKKLQPFDGGGIDLLLSRVSYQLTDLLRSPLAFCFGTLTALYLRMKLLGGLGANLTSSIRGNWTAAATDMAKKVNPMVAVDQLLQTATDLLGGLLSQLQTLLSAVQLILPIIVGIFALFCAFFLLLARANRQNCPAEVRKNWWRKYHRRTEANNANVSQVPCRWIKSLRTSTIALVELVDHVNRFLSVLTIFLPVFIVSLALFLIMIIALLALSIFLQFKRHINQSRGEKMEGNGASRMRRPEEGEAAYGIQWSRPHQEEAIPSPPSEMTSPTSPTGEGIPLPSVTLLEGKEGRRRFWPIQTANAFPSSNNERAAYPADHVGTTPVSPGLSPTSDSVFLPANVVFGRHGAHNAGQFSAWGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS53</accession>
    <name>A0A914HS53_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS53"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3959.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3959.t1"/>
        <property type="gene ID" value="Gr19_v10_g3959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036673255" evidence="2">
        <location>
            <begin position="24"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3959.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28026" checksum="26A1716104C178C1" modified="2023-02-22" version="1">MEEFWISILVLFFATNLIDKAEFVQLEELENLQLQTFDEIFGEGWWDNDKADEWDKLSLEQNVLHQIDRQNTQTGQIEPNSTDKLGQIELNSTDQNPPLTDSDQLGQIEPNSADQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQNPPLTDSDQLGQIKPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTYQLGQIEPNSTYQLGQIEPNSTNQLGQIEPNSTDQLGQIEPNSTDQLGQIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTI7</accession>
    <name>A0A914HTI7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTI7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3830.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3830.t1"/>
        <property type="gene ID" value="Gr19_v10_g3830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3830.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14445" checksum="DBD07F76C1F4B6C3" modified="2023-02-22" version="1">MTKSRRVHGHPDIRGYIRIRTDNGYGISESHGYGRIMDMKNPLIRIYPLYIRGYPDMGFWKVLIQSSELAKDVAGAEPLLEQHQEHKDGDDAKELAASSLILKKLRMEEEAHPSAAKQCRRLMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTZ6</accession>
    <name>A0A914HTZ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTZ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4192.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4192.t2"/>
        <property type="gene ID" value="Gr19_v10_g4192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF344">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="117"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4192.t2"/>
        </source>
    </evidence>
    <sequence length="222" mass="24995" checksum="422D90C4F40FFB8D" modified="2023-02-22" version="1">MRLKKCSRLHHLEPPQITPSLLFGHCLLLRLRTFVSVLSPSSSSTSFSSVLVAVRVLAIQREKKLKAQRIARMLNGKVTYLRNPTEKERQRDQKCVFDNLGVQMLQNAWAGYNCAINESSSRAHTIVRVEFTQNCGKPYSMRTSEINLVDLAGSERLKGSPNDGERLREDIRINQSLSTLGRVIKALYDQQNGKGTDQQIATISPANVHYEETLSTLRLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU09</accession>
    <name>A0A914HU09_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4665.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4665.t1"/>
        <property type="gene ID" value="Gr19_v10_g4665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4665.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14267" checksum="C62CB40F66C0B79D" modified="2023-02-22" version="1">MRKGRGGKIVIGVINLEKKKNRDNNSKQRQQTSQQMANDDAQNEEEGGSRRNQPTSDSGRQYAEKLTKQSVTQRKALAGAIRGQRNRGQQKECEQVGEHTEKQRIQRMDTLGTAARKAKFAVDSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU59</accession>
    <name>A0A914HU59_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitinyl hydrolase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HU59"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4226.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4226.t2"/>
        <property type="gene ID" value="Gr19_v10_g4226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106018">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="7">
        <location>
            <begin position="119"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="586"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="777"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="269"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4226.t2"/>
        </source>
    </evidence>
    <sequence length="1276" mass="145343" checksum="460E59DF49BA7417" modified="2023-02-22" version="1">MNNNFYIKQVQLIDSISSEISTSGTVHVLGTHFIFKADEGGKEIWVSHTLIALLDRGQPTLTGSRLTIRCKHFLVLIFLISKEKDSQSLYDTLLRCSRLTNISECLAFANKKANCAPQTWHRLNWSEEMRRQGVEDIDSWTVSDFNANFVHCDTYPEQLWIPKGATTQILIASCRFRSRARLPVLTYFHKNNGAALCRSSQPLAGFSARCLEDENLMEFIMAANPSSTHLYLVDTRPRVNAMVNKVQGKGFEDTRNYTNIQSHFFDIENIHVMRASLNKLLEACQRTQTMSQYLKTVDSSGWLRHLKTLLDCSVFIAQTLKGFQVLIDKDWLGFGFKFDDRCGHLGASNEEMAREVSPIFTQFLDSVYQLLRKKPMCFELNERFLVELNEYAYSCVHGQFVGNCDKDRKDLRVSTRTNSLWAYMDLHIEDYQNPFYEPNSDSLLSDIDLNLSSIASREYLNDIVMNTKLHVQSMKTASDLENSRAACAWQSLLSADECANEKCRREFLSRIERRVHCDSCGQIYCHRNITMPDKDKTELYTDLTDETHFDFCRMAWLERKFLGLCDPLTMCIPESAFVTVVLPTTKSMDVASAVFRLFSKNNNSSIGLREYVYGLSRLCRGPEPERIKFVMQLWDSDMDGLLSRKDLTDCFKFFGLSMVEILSHSPLPTVPDALRIYEFVCLANANPTVRDALLSFSNKIWMALTNETKPMKTNKGQDNNAGKEHDHDKTDADDEQSSSSSSSSSSSSDEEEEGENGHNLKKTSGKKENTENRSQLGGVQNIGNTCYMGAAIQTLANVSELTGFLFKHEQHFFHLPLVRRYVQMLRTLLVQKETASPLDLKEVISAKSALFAENVQHDSQEFMQFFLDALNESLKNIQIGEELENKKATDEEGRADDGNVQEDGMWQNANNHWKKEALTSKERSIVLDLFAGQFLSKLHCPNCAHSSNTFELFTMLQLQIPIPESIWVFFKVVKSDSDSAVVRHALQIPPITELVRLKQLICERICIATDEVEILIQNKRDGKYNADFSRLFNAKNAHRGGADCTLMGIPLCDINIWCIETNNLSADCSDCLMYAINEKTRTLDDPSLLNADRQTDARLLNVDDCVKDFTGVEQIDGSHCDNCKSSASKLSKQLSFTRLPDILVVSFKRFIFVPSLKRFVKQSAPLSFPLDNFDLRPYFAPDVPEQFLNNFSRYFCIGIVTHSGQLNYGHYCSYVRNVTSKRWFFCNDDKIELIKSGCVPTPKDAYILFYQRATDTPSAPAVRREDATRKDNNVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV10</accession>
    <name>A0A914HV10_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HV10"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4425.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4425.t1"/>
        <property type="gene ID" value="Gr19_v10_g4425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4425.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8053" checksum="44F7547B4F26A27B" modified="2023-02-22" version="1">MDVEVSESFGVGDVVGCGVDLATRQLIYTKNGARLAIPDLFVSSTTGDLFPFVLFRVPGDGPSDGKIEANFGPNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVF8</accession>
    <name>A0A914HVF8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVF8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g435.t1">
        <property type="protein sequence ID" value="Gr19_v10_g435.t1"/>
        <property type="gene ID" value="Gr19_v10_g435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g435.t1"/>
        </source>
    </evidence>
    <sequence length="580" mass="65589" checksum="CF229581B615D021" modified="2023-02-22" version="1">MNRHLRPQLFALRQDVKQQWAILSDTKEMAFKWPSNCPLEVRELVGPENFDASNPKYTMPFFWRSDAVLATRSWACIVCAVECSFGLLSLLCNVLHFVLLLLPGGQSSANVRPTASPLVPSTVLSLTLLQHAVFFCFKSLFIIAIFTRNPRLMRIQLIFQYFTCVLLLLNASFTLAADFGGYDERRIYAKRNPLLIRFVAFLSLAFIPVQLYLRLMTVPVYKFLRDLRKFRHAIYNGKWRYRKRVYFTYCSLMMEQQKNLNLLVSRNYNGSLDDGQQTPLTATDENSSSAGRGSGSADAAIVATPRLPPPAVSDGRERKKRKTKQQQREKNVGKGLNELEKNAEEELQLLGQTMSDSNWSIPSLLTLEQREQREKEGAEKRLKIKDDEERSLSVKMTPTQNLGLKMARARTVNTSTILPMNLAATNREEEDEGVLLRVGDGGEQTEGIERRTAIQGEKGEVRHRTTPQADKPLGTADIDSKSPTEEVLLLINSPVTSKEMPKLSIRPSRTRNELDGSDRRDASARGTGTASRTVEIRVEMGQDELERLMGRARGTTTTIEWEANTKKKVRLALLPLLKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVH7</accession>
    <name>A0A914HVH7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVH7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4554.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4554.t1"/>
        <property type="gene ID" value="Gr19_v10_g4554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4554.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26419" checksum="40DDA5BDD321B1E3" modified="2023-02-22" version="1">MSTNSTINEVFYELANARPCWIVYVTLRTKSMNNSANKLLAIYSFFEIVHQSVGCTNFLLFFTSIDRLIAVIFPLRQSENVLIYVITLPFIGLYYVYALYSQSCHLTDETVITGTINDIGMAAFQCTNSSDFIWPTIINLMLLTTIVLYAVIAIIIYFRKSPPNSNSHQFNIRIFRSLFCIVSVNISGYFVIAASNAPILYFTSKEYRKAFDKEWQTIIKLFKRNSVQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW37</accession>
    <name>A0A914HW37_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HW37"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g431.t1">
        <property type="protein sequence ID" value="Gr19_v10_g431.t1"/>
        <property type="gene ID" value="Gr19_v10_g431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g431.t1"/>
        </source>
    </evidence>
    <sequence length="579" mass="66572" checksum="21E6D803CAF264D4" modified="2023-02-22" version="1">MPPTLKEYFFLDKLAKAFGMLQRIGGLRAAIKQRYLTDANRAEIGNFDIHMRIELVFHLFMLCGFALSNEQKTKLCADAMCKGDLFPSNFIRAYESADLTFLKTKVNSPVKIVGFQFSERPDLLEAEDDEGKRGFIFDSHIDQTPYVIFLESALKRNQTLYMIERNGEWPKLIKEVAAVPELTRLYKTFADKLENYPLDKELLASLTESEAQVDKPRRMFREWIDAVRNVLPEPFCHVENTGLIILAFVFLSAFVHLINCLLSSNSGPESFDHRLLHDCITRLKEQELIIEKANKKAVNQHLAEAATDQLQKQNEELEQTLKTVEKRTLEFESENGKLKQLLNNTQHELEQCLALNTELKASVEIKDADLKVANEWQRELDRHGFMQQCTKLLQMMEEKVGESAKLMEEKEKKVERSEQEREKLRTRLSEVELGLLRVEDEKRELQHRIKELDHSLKQSNELNGQLENKHYHEERRLNTKIRQLDEQLANATKSSLGEGVSNSSDREVCSPDGARGPSFISSLWSEIDSNEPVVELHNSDAAVRSSVAPRQRMRSRSAGRQSVARLTGIRPIHGIVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWG7</accession>
    <name>A0A914HWG7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWG7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5121.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5121.t1"/>
        <property type="gene ID" value="Gr19_v10_g5121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="37"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5121.t1"/>
        </source>
    </evidence>
    <sequence length="645" mass="71487" checksum="A2C8D4CDA98A066A" modified="2023-02-22" version="1">MSLNSAEQKHLLGMGRVPSLRRRHVPRRQVSDQLFLRLKNVLTDSDSGWLLVCGMVGSGKSELVTELLWERPELCFVLVDRVLWVADRRFHSTELEHLATDTLLLASLLCATDVSEIANCDGLGLVAIAQRLNDLLNDTIAKTLLVLDGVQMVETVQFFDKIKGPKCKILATSSSRTLFESLEGLQTFAMPSDGCTNEELTHMARNYGIKETFLSERINSILCRTGGNFALLEKMFTLARGSSEIFDSLLAQLLHGPLSSVGCHSAYYNFSLEKSLELCFERLGQSLIRSFDYCTFIEPFQWTSFEIYFLIWPLDVCGSESEATLRATVGVQLDTLEANSLLDKSAEGADDDPNNFSAFRYRLQPMVHNFLLHSRPNSMATFNTVQKMISLKLRNRSSSLSDRRQITAYLTKNEHSLAIVQKHLDQRIYQRCIEDKSRSGVWSFGGINSADGGDRGLIRSTTEMIGRPSAKSSFALERLQTGPFFADSVFIITSWSAHERVPAGLRPAKAVNEQRAGGEHQNEPITFSTTILQPNDAKNSSRPLIFHKNVKTGRKNDGAFGIAFAINATEGTPTKARVTIPPPAGKDFGVNTILQTNLVDSRGRVLKGVSAVQLPVPDIRNSKDSRASASQVEAEENAIPIKFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXS9</accession>
    <name>A0A914HXS9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXS9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5460.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5460.t1"/>
        <property type="gene ID" value="Gr19_v10_g5460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5460.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25121" checksum="E34CF548DB0773BE" modified="2023-02-22" version="1">MLATSIFMRNTRARKEREAFANEEAANMRNFCSEFFTEDYRRYIDANFVLNIHSPTTNKPDKDGIRSRSASDGLNPVNLTSFVFTTSSTPEQQRLQQQQHVQQEQRISVVGSGDDSMETNASNDFAAVAVQHFPQQRQSDESQQQMPAIGPIGSATTAASRNEEPKNGGKDLKQCTQWMEQQQQPQQQLFQTLSPGTSAFPAPLLAVPRGCSLWRLLDPCKFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYM7</accession>
    <name>A0A914HYM7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Centriolar and ciliogenesis-associated protein HYLS1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYM7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5000.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5000.t1"/>
        <property type="gene ID" value="Gr19_v10_g5000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027918">
        <property type="entry name" value="HYLS1_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15311">
        <property type="entry name" value="HYLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centriolar and ciliogenesis-associated protein HYLS1 C-terminal" evidence="3">
        <location>
            <begin position="224"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5000.t1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55701" checksum="2A2B87640067D5C8" modified="2023-02-22" version="1">MDLDLASNGDVFEDFGDLVRDIINEMGYNVEEQQLQEIEKDLRLLDENADVADSKLFSCLLDNYSEFSTFASDPEQSLQQLVAKVDSDDRRPCSTKTQVKRSREFDHLIALGYERLHEVYADIKRYEQLLEETDTKQIDQPNTTNATSEDDFEGNSDQFSQQNRPKGAAIKGQIPLKMPTTSNGKENRRPTHSFGTMKPREETRLLNHLLKNNAMRRTMCPAPGRLPFKHDKQLKLEQYRREWGKNPPPGEQKRMALRWRIRELMMTREIPQLRIITTDEYFDEGADQQKMGPNEKSHNFSSPIKIDSIESDDEEMARLRAEGWHVGFGVEMRVAVVGEGGGGGAGDDDNRTDSADSSNNDNECSDVTTDDGQNDEEEENVSTPYCGYLPLPSSVADDDGEASSTSTTTTTAALQWLPTNSTPNNLSLLPPPPTADMDHIRHQPIDINLDQVKVDEIRIIMAQMTMSTQQPEWTRQIDDLKLAELVKRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ05</accession>
    <name>A0A914HZ05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5787.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5787.t1"/>
        <property type="gene ID" value="Gr19_v10_g5787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5787.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12546" checksum="56D5C6E9104AE013" modified="2023-02-22" version="1">MAAKGKQNKQNKKMSFCLSSRDFKNPLCQICEKDVPPTDKIVVDRLTIHKSCFKCAICDKPLQQGSCNLERGLARYGTFWLCREHSLIPPGEKEELIVKKGYKERSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I052</accession>
    <name>A0A914I052_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I052"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6267.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6267.t1"/>
        <property type="gene ID" value="Gr19_v10_g6267"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6271.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6271.t1"/>
        <property type="gene ID" value="Gr19_v10_g6271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6267.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6271.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12960" checksum="ADFA6D543338924C" modified="2023-02-22" version="1">MLYLAESLKCGVKHVVGGKFSQHTLDVVEGNQCVYAKCMEQSQAWHKFSDCKPDSVNCTHLTRECEEQGAKIAAAQQRMELRCQGRTPPRPQHQRQLPSRRQFRPKRRPILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0A1</accession>
    <name>A0A914I0A1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase-like protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0A1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5415.t3">
        <property type="protein sequence ID" value="Gr19_v10_g5415.t3"/>
        <property type="gene ID" value="Gr19_v10_g5415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5415.t3"/>
        </source>
    </evidence>
    <sequence length="356" mass="41583" checksum="B70EAAEE77582D50" modified="2023-02-22" version="1">MIFIEKDLALFDDLELFNLVYQPQLGDTKSQLKPRDEFYQIWTPFYMNSQLKNLMNDEKEPNTGKRKRRKRKAPSPPLEGGEMRDFLFSNCRHVRSLFEKFKSTFKSFDDANNQRTNEIARHCVKMAPLFHHSVLFADGSGLLETTAEPTGETTRRFSAQMAEIVPFCDVALTRHFLSQRFDKFDFIVADPPWPNRTVKRQRTYQMFRAGKLSLDHPLDRLGQLPIPQILADGALFCIWLSNSRTAHTVAHELLDKWKMRKLAQWHWLKDWRTNCAADTAKWEKIPKDFCVVSVPNANPSRKPPISLLLQQLGFICPVKNGLELYARYLLPNFTSVGYEATKIMAKFTNKKREFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0I6</accession>
    <name>A0A914I0I6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0I6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g636.t1">
        <property type="protein sequence ID" value="Gr19_v10_g636.t1"/>
        <property type="gene ID" value="Gr19_v10_g636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g636.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36728" checksum="4DB74A38426B1C4C" modified="2023-02-22" version="1">MSAADDPNAGAPAQNQACGLEAIVEVKNETETPISVISKRFWAGKTTIRVSDMENAHAEILKLEDGVNRALRSVNRSLNLKGQWVNQVVSNANANFETLKVQVNTLAERVDELERASESTEPSETRYGHTPTFVTPLDGRQGDRGEDSISEEEQEEEDRAVYEVNMLSNTLSIGSSLEVFGEESLFAFEDWAERFKDYLSVSGKNWTDEEKVTRLKLALKDTPRALFKELLPAQIRTVDDALNALRAKLDSPQRREIAKRTLSLCKQREDETVVQFLRRLSPLVEATNPSLSCDQRKEKVCEEFWLTRTTSMSSDRRIANMINVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0V6</accession>
    <name>A0A914I0V6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase A2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0V6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5859.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5859.t1"/>
        <property type="gene ID" value="Gr19_v10_g5859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053322">
        <property type="entry name" value="PLA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228">
        <property type="entry name" value="PROTEIN CBG09474-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5859.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="14900" checksum="3B946C919EBAF62C" modified="2023-02-22" version="1">MFMSENAVTRDCPTRKNGFNNCCVAHDLCYSAQTGQINCDDKFCNCLAEAANGTRVCAAYEAKAFCLLVRQFGDGPYRASAPSILNINCTWSRCGFWFNTAKQLGCDCDGTETRGCGPLGIGRSYQCCPTCLINGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1C0</accession>
    <name>A0A914I1C0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1C0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5974.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5974.t1"/>
        <property type="gene ID" value="Gr19_v10_g5974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5974.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13613" checksum="C5AE9FE1A6F284A3" modified="2023-02-22" version="1">MGFLDDESNRASGFIRSGHIMFSGRGGDSLVGRMKHLLSTGNGADVHFMVGDGDKKEARQLGSGQLGTGQLGSEDNSAQDNSALSCAELSSLPSCPVPSCPTAELSSAELSTAELYARRILVQEKFENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1E5</accession>
    <name>A0A914I1E5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1E5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6601.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6601.t1"/>
        <property type="gene ID" value="Gr19_v10_g6601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036811691" evidence="2">
        <location>
            <begin position="25"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6601.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40573" checksum="348F6694E27B1135" modified="2023-02-22" version="1">MCFFYSAKMAVVFILMLSSATLEAKQNDKFYDLITAIGEHFGGEFKDAEKVLELDLNGANSFLDELHTFATREIVTKNENVAIYKDDKYKSEYRKGEAFKLSRKNYQILKQLNDQKFSIYEKNTANFLEFVISNTFGIDPELHFNSQDKEIQEYVQKDVEENCKKFDDEEAKIIFLNNVRYDLAINFEFNQRKDVYERIEHLLIVWVYYAKFSKDIIEALIGKDHFQPFNLVSLFDQIKTLVEVAIPKEEANLEKAKKEINAELLAKDFEFLENNPKNIAEEKYQKAFAIICTIKQHGEKEQLGVWRGIEEYYLSIPLLKLTEQAQTLAITFGKMLENVKEYYAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1P4</accession>
    <name>A0A914I1P4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1P4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6063.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6063.t1"/>
        <property type="gene ID" value="Gr19_v10_g6063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031736">
        <property type="entry name" value="REXO1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15870">
        <property type="entry name" value="EloA-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="1074"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="613"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="707"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="709"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6063.t1"/>
        </source>
    </evidence>
    <sequence length="1237" mass="137351" checksum="3CDA12B7E9EE2D7C" modified="2023-02-22" version="1">MATVSSAHQFPPIQGHQGPSTVASASKHKRPKPTPGGLPAYIPTPIAQLEKEQKEREERKEQRRAKHGGEHNSKKKRAEEEEEEEEEEKEQGEQRHKRSAEKKGKEKEQNGRGRESGKDSETAKRMGTATKERKASISADDDGGLDIDRIMDGQKQLLDEIADDPEKKMREILRVEAEHERRLRLAKQKANNKKFGSLKQTIGAKTSSKLATKIGSKLKKIEKKKTSPKKKKLTSTEVKKAEKKERHTVIKSLIDDEQKKRQREEMDKKKKQEDEAKTAKKKFTSEVNDCVKNVAQLDMRIQKIQSEMRRSNNKLAMMDIGKSSTNSTNSSSKVVGTNSLTSAPAAAAAVVVDKEGAAEKTTPSTMATKKVPVWRKDSDHTSKPSTFLEDNRFYLASQRHPIPAALRRNGTTSKSLDTDPIICELFGDDDVEEENAMIETKKRRRKQSADEVLPNSKIWPLGGNSTTNAMIKREKKRPKREEPNGDDECLRKERQAMVDSILEDESEKDEAAAAAEETGPKSVLSAAAIKRGKRPLSRSPSIVSIQSSVSVVPETPPTSPPPATGRLQVLPQATNAATGALLVQQQQQRRVPSAEEQLHTRTVAALLASVDRKKDENAQHHHHHHHHNKTVANAADMEWLTKPKEKSKKSGSSILNNTLRQPPPPAVAAVSTTSTAVANNNNNYVPTRVPMHHASQRPLAPKLASAVLSTTSTGPSSSAAAPKQQQQQQHNTTTSSSTVPKGGVRKAHVPRFQGTNSTTTPSLAKSLVPLEPQNRKVPLQIRQRHLATIHAEYVKICGDDPTSAVDWAQNEEKAVLERCNGKLGYLAAIPMLIKRLREAAADGHHHHFHGGELRRKMSAGDSVSHSSVLLGRHANTVTCGLHRADRTSSLHKTTNLSELDFYNALQAEYLLSEQQLWDNGYPRWASADDEVEEKEIDFDEPSVDDAAAAAFGIRRLVLIRQSDLDAGKSRIPFVDDSVLSRVCDRCGKEYRLTKGGEYAPGSSSDQCIFHWGRAWKKRVSGTIESRYNCCDQPLTVQGCDVAPNHITQTQRLSTLRRYVETPRPFGVGDPRSKKVYALDCEMVYTVWGPEVARLSVVDITGELILDVIIRPEHRIVDCNTKFSGLNTDQVMAGECDLHEAQQRLFELVNTETVLVGHSLESDLRSMRLVHRRVVDTSVVYPHRMGPPYKRALKTLAAEITQLIIQDDESGHDSKEDAVGVHAHHVAQGQRCCLKWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1Y1</accession>
    <name>A0A914I1Y1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1Y1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5861.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5861.t1"/>
        <property type="gene ID" value="Gr19_v10_g5861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5861.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12635" checksum="CA94293F36C604B6" modified="2023-02-22" version="1">MHHNAREEDHLQQEGGHQGSLCPGTVTGVYVTREHVGTQRRLIDKGYTCKIIVRKSAGTRSRSGLKLAGRFATDMRTLIHPFRNANGRTGRLLMNHVLKCLGQHMIIVPGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I287</accession>
    <name>A0A914I287_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I287"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5939.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5939.t1"/>
        <property type="gene ID" value="Gr19_v10_g5939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036926304" evidence="2">
        <location>
            <begin position="22"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="4">
        <location>
            <begin position="98"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="253"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5939.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46609" checksum="E9E1F938635B4F72" modified="2023-02-22" version="1">MRKSFLLLTIGVLFVIQICNTVQNAINVDLSQLDRQLQELQQRADQLRRQIAQDTDPRIKESDSRTLQMLSEKISQIQAQKKSFQDAEQNAQNNFGGPVEEHYVKDFARNCLDYIDKNAANLIKSKEFLQIDQKLLCEIFGRDQLIVEELTIWNAALRWADEKCLQNGKERSAENRRAILGPALFKICFPLIPQKDFSATIVPSGELTSDELVSIFQYHAHPDRALHERYPLQFPTKRRTSSDPYKAKGTIVLKIEKVSEFARDDVIDHRLSEAVYIRGLPWKILASSYAYYNNLGFYLRCNDENTDSNWSCAGSATFKIVSQKEGKKDHTRVIFRSIFNSKEKRWGIEFFKMSFKVLMEPKNGWYDAKNDTELMDPQNGWYDAKDDTVILSAEVTAKEPIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2C8</accession>
    <name>A0A914I2C8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I2C8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6673.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6673.t1"/>
        <property type="gene ID" value="Gr19_v10_g6673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6673.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="16987" checksum="1A97AD119C8AC1F2" modified="2023-02-22" version="1">MVLPLSLLKTAQNHPMLIELKNGETYNGMLVACDSWMNVHLRDAICTSKEGDRFVKIPEVYVRGSTIKYLRIPDEVVDLVKDEVKEVRRQQKENQRMKKQFSRGAPRGGQSGGGGGRPPQGSGSGGGGRPPQGGGARGSGGQSRGAYRGGGGGGQPRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2D2</accession>
    <name>A0A914I2D2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2D2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6865.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6865.t1"/>
        <property type="gene ID" value="Gr19_v10_g6865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6865.t1"/>
        </source>
    </evidence>
    <sequence length="665" mass="71363" checksum="FE0394045B8BDB19" modified="2023-02-22" version="1">MLNPTDFDQFVAELDLRQRAQVDEGQRTADVARPSRTANSRVKLCLPTLVKYLTTIEAAGGGSRKSAFERFKGNRGAMALVEQLEEIGFKMDRKTLTKYIKDIKKEAQQNPGFESQLTEWDFSNPAPQFIQATQIAQQSSNFTSGNPGSSTSASNRGKSINFSKGSNTANWPLSSITGSASHYGAMPSQQAPQIAQQSSNFTSGNPGSSTSASNRGKSTNFSKAPGSSSHHQAPPTDDTFVQSHAGIDSTNWFGGNSQNDEGSLQSMVNPKKPSSWKNAWGAVSNLFGASPQEPQFLPPMHDTSAASSYYSTNDQTLQSMITPRNQKGFYGTPYLPNQSQSTGRTGASNFSSSTPKSSNFNSGNPGSSSHYGGAIPFQQAPMSGTLFPAFSNQPSNQSAPLNPSTNSVSSQPGTPSLDWSGGNSQNNDGSLYSVVNTRRPSSSIGLKMDIKTLADYLRRIEEEAQQNPAGFGATDHLPNQSQEWDFSKPAPPFIQAPQIAQQSSNFTSGNPGSLTSALKRGKSIDFSKKNSDNWPLSSITGALSHYAAMPSQQVPPMHGTFVQSQAGTDSTIFFGGNSQNNEGTLESMVNPKNPSSWKNAWGAVSNLFGASPQEPQFSPPSMHDTSAASSYYPSNQPDDQTLQSMITPRNQKVCVIPTWNAFFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2H1</accession>
    <name>A0A914I2H1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2H1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6707.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6707.t1"/>
        <property type="gene ID" value="Gr19_v10_g6707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6707.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9883" checksum="0BB1B57531DC5C07" modified="2023-02-22" version="1">MEEGKKHVNTREGTINTSWTTIDGGHTICVQQRRRRKGKDGGEGAAADEEDEAGQFTDEPCCSSSTTLKCSESVHNNHQKICGSEQPLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2S1</accession>
    <name>A0A914I2S1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2S1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6330.t3">
        <property type="protein sequence ID" value="Gr19_v10_g6330.t3"/>
        <property type="gene ID" value="Gr19_v10_g6330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037355483" evidence="1">
        <location>
            <begin position="26"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6330.t3"/>
        </source>
    </evidence>
    <sequence length="682" mass="78203" checksum="EF8F55A4276A7184" modified="2023-02-22" version="1">MFKFFYYSFFFVIKFFSLPARATCCAPPPSPISVLQYPNIQGAGVSQYANIYFMNGVPPSQQQNTILWQRQGAPSVKMVENDNTVAQITAQNATENITTLPNDDELLKSGSTMELAPRINAFKPNLLIRPIENIKKINANLTAFRCPLNESARKLSIDDLLSSIEVAARPFDGLSNVNGILPVPLPIQFCTFEEPKFDDKQQCSFYSSESENLQFKIGRFCNKTMPTALFVKSFANQIKRPIDDLPKDNFLMLIEPFGVVPSNSAILKMDIACQKGDGQLSFNYWCTTEQFVLKVCTRFNFVRQCTPQIFNSHNSSRVEVLVVNPSLESFGQFSVEIIAEDFAEPSLMILDNLHYEAKQCPIYDEQENVAQKNKEFVNGNTSKNYSKISIKQNGLEQELSPKNSNKFNKIYANMRPVVDGAVTRHKKPFFDAISEDENAIEVNIAKRELLKIGGKLAMFGQQRTNLAENSDLLPQIQFRRRNNRQPKLHRKLPNACELLKCTFTDTFCHWSQLEQMPFMKIRTGKWQIAKPQELSFLMETREKISNLQHSGYAYIGNDQTLHGIVPKKEVMLDNHHHRTRRTVYVLQSPEFVLSKNCSNSALIFDLYKRTNAIIMKICLNSMMNCVYEAPYSEVNVYWRMREKIELPPDTNKIYVIATQWKRISWLAIDNIRLLEDGTECQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2T6</accession>
    <name>A0A914I2T6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2T6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6340.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6340.t1"/>
        <property type="gene ID" value="Gr19_v10_g6340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6340.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36847" checksum="1686E57CC0CADF53" modified="2023-02-22" version="1">MCSSNSAGSDSDAKISEQLSAININEKASVDYFGSVLPTEILVKIFDFLDNDHDSLEALHFTSKRMAIRVKPFLMAKRKKLLDAFVDFLNLNIIEKDVLHNEMFTGSSSRVESVNFLGNCALLLLESEKYLKRVLRTNEYLSLSAHNLPVAQLSNVLLGVSGSVCDEDQLSREERAFKLLAIARRHCYKFSIFYDRLTADLQLQYNFMYNYPMLSKFTDVIWPAGMAENVKVQLAKEYAEKNKKTAKFSKTRRMGRMYEMRTHGLVGNPYTTKPVHIRVRRQIPYYHRYCDDSDYEHDYYDYEDDYLHEHRYGYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3K9</accession>
    <name>A0A914I3K9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6505.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6505.t1"/>
        <property type="gene ID" value="Gr19_v10_g6505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="279"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="894"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6505.t1"/>
        </source>
    </evidence>
    <sequence length="1453" mass="159290" checksum="C864A4E781260EFB" modified="2023-02-22" version="1">MEEDERRKICELIERWNGSRLDMFAISCPDENMEFHGVIRFFLHEQQQQSPATGTAATKCMRVSSAHSVACVVHALVAKFHADMRMLAPASAYALWELHNDDNGAVAEQQQQRRMDAGERPLLVQLGWCCCTDEQGSGGGGMREGRFVLRRADAPATPPVVQSPSADFVRCIPRRFSKRRQAQAVPATTTTSALVGGSVKSVGGGKKRLQLRNNEIGTPRHLYDTVPPASSSPPPPPPLLFSPNALTPFARTLSNPELVLKRRREQKLDEQLRHMSNSGGGSLKIYGVELFPQRPYVTLLVNATDSAKRVVRAALDKYGLEQADSSNYALAEVFLMESDAMSRSFSDLRSIEKQRERLLYASERPLQLLAEHSTSNNVVFFLRCRPSTPAMSGSSYTLDRLFPSLHRNNDELVAAHPNHHHHHHQQKGRHVDDDADVDDHDRLMRRMVNDGVVVSAGGKQTVAAAAQFPSSSLPLLLPCLVPINAFASTANFGAGAVAIQPGVTEIGSSSACAIQLRAPSVLPRHCALHYRPNSSSVENNSQQQLKQQQQEAEDVPEREGEVIVSLLDKSALVELDGASTHADVRLQNGVQLRIGGVYCYRFFSNNSNNNSGGVDHGECAPPATDHIAEHDGTGMSQHRMQKEKLPSSSASVSFSSGPFNSATTVVHCIDPQHHQQQSEAALIVQNIFSPSVSFEQSNSNEYVELYKSSPLVGTPSSTTATPTSVAEQEQMLSLMPSAQQQKQQALQHNQTHHMHNQFHNNHDSSMRSPYKLPSSSPSSTSILPVYQHQQQQLPPRSAATLPILIECTDWRSEVELFKSELFATTNNNNNNNMATTTGSSTVGQQFGAFRLTPAFVLYAICRHRLHVSQSAAYDEERCRRLVGNTFAMFIDNCSRTIKVNHASRETLVFWLSNASELLNMGRTDAWLARAVGTALLDELAHVVQQLFTLLVEHCGQQLLGQGIQPIVQQWMLLLLRNRGAAGAPATATAAQQDGVPSLLVVAALDECLRTVRWALLNPALTIQLFSQLFHFISTTVFNWLVTEPEARPLICQQFGLLELKQLLDHVQQWAEQQGLELAAECHMDRLCQVVHLLCTPKNLQQVAVLGATCYRLNSVQVRFLLENYVGDVHAGETPAVSRELIEHVVALARQQQADDHHQQPSADGSMASSSAPQLTESTTLQLPFLLPHDGYVVEKLRGIPPDMATFVNALQQKGLVRVFVHQQQQAAASPSPLRHGAVPAEMPLSSWNVHMRHQQPSSSSSASAQCLPGKRSASITPSSSAFPTVVAPGAVAVGAAGAVTMFPPTPTPPPHQQRQLFNNGSSSSVAAGDSPVYAEIRRHNGGFQQHPQQQHPLAPPPPIRCQSASVFGTHHNTTNNNNGSNNNNQQQQQLQKKKKSNGYPNQQQHQQQQHQWNERLIDAEGVQQLLVERITLCRPSGKSGGGGIGLSIVEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I491</accession>
    <name>A0A914I491_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I491"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7367.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7367.t1"/>
        <property type="gene ID" value="Gr19_v10_g7367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036918050" evidence="2">
        <location>
            <begin position="30"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7367.t1"/>
        </source>
    </evidence>
    <sequence length="688" mass="74050" checksum="F64499D73440A73B" modified="2023-02-22" version="1">MNARLSLNVSFLVTICLLLLLLNMNEVHGKKRRHRPVQRAAKISKSAAIDVKNKNCEDEQGGAAKENKLLSPWAWKSDNSLAFDIAITLPPADGNSTRTSSSNTTTQLTTMASSSTTVATEQFLLNDVDGMAQQQPQREAAENGAGNLTALSATERELDNSATIATTTTTKPLQTESWAQNAEEPAELARNRLKPSLKFTGANASAMAPDVGTLPPGIEPSPPAFVSAEELLLNNKLIDDIDMATQSSSTLSNDSLAADIGPRPPASRGISGRNGSTDSTKYWRFTRLPYINNGTEFAEPAPIVPFNSKAREEESLTDLELQPPHLGQADFFTLPDNGSSTEVSAGGDQTAEKAKCQRQRQESANEKAAADYHVQVSEPYPAHSAESTVPTSPSDTTVLPITAEGILAGDQSNKKLHEAPTPPKHNLISFDAAVDNKTLPGTDQSTVVVDDRKGADKLFNPLNNSIEGNVIKTKEENCCKLLRFLKGKRDNGSEFASAIDGEEGGISELFSGTDLGDQKIIDAVESNNKLGTKGREEAEANEEKLEGATVKAHWEVVQDASTTTGGGGGLEILKEELRERDFNRIQSHADSSEHRTPTAPLNLANSIETATTSSSISSFLPSSTTPPPRPIKKWTPYVFDCALEADERGESLCQEWAKGGLCEINRATRFLFCRKTCLCIGILDSANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6J0</accession>
    <name>A0A914I6J0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6J0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7080.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7080.t1"/>
        <property type="gene ID" value="Gr19_v10_g7080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35017">
        <property type="entry name" value="PROTEIN CBG16223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35017:SF3">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037907821" evidence="1">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7080.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19057" checksum="030877E5AD1D3C28" modified="2023-02-22" version="1">MCSAIVSLNGLLALFGSLTLILAHQKTSRPPCCMDTLSSSVCQRLRHEKRVHFARRCNNDIEFRLIQCCSTCNRFKRSIPYDRIAQSLVRMNCDDRYGASFCKKYVNDQDVWTYKQWSCSGYSPYMAFRACRKTCGFCDFDKVHYNLRNATDACKSIPEDKDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I768</accession>
    <name>A0A914I768_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxypeptidase</fullName>
            <ecNumber evidence="5">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914I768"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7384.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7384.t1"/>
        <property type="gene ID" value="Gr19_v10_g7384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF418">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038172908" description="Carboxypeptidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7384.t1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55592" checksum="1EF5D84F1CE23BF2" modified="2023-02-22" version="1">MVPLILLPFLLLFSSSFSLKIVFASVDEPELCTRLTTAGQDEIAALPGLTFRPNFKHYSGFLKTTDKHYFHYWFVTSQNKPCQDPLVFWFNGGPGCSSLAGLLDEMGPYLINSDGKTLRQNPHSWNKNASIVYIESPDGVGFSHSVDGGEPDASNDDSTAAQNYEAVKQFFNKFPLFRVNPTFITGESYAGVYVPMLVAKIVDGQTQFPINLEGMAIGNGYMNAPLDTDTLARFAYGHGLVEEKEWQQIEKECCQGCLDTCDLGTQYGNCRQKVAKIVHFCWRGGLNVYDLYQNCAPHSSKLDIIRRGIFRTKSLHLNESVLWASDNDNEFEGFENANGDKMQHLLRCLDGRPLVDYLNIPQVRKALHIPTTVTAWDQCSDRVSRKYRVQYTDMSHFVWKALWANVRVLLFYGDTDMACNFMLGQRFSEMLGLKRLAAKKPWHFDGQIAGFKTAYANGFTFITVRGSGHMVPQRRPAEIEYAFGHFLANRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7G5</accession>
    <name>A0A914I7G5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g800.t1">
        <property type="protein sequence ID" value="Gr19_v10_g800.t1"/>
        <property type="gene ID" value="Gr19_v10_g800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000018">
        <property type="entry name" value="Sodium bicarbonate transporter protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000002">
        <property type="entry name" value="Solute carrier family 4 member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1179"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1254"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1304"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1360"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1393"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1434"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1459"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="945"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g800.t1"/>
        </source>
    </evidence>
    <sequence length="1494" mass="164348" checksum="198E7040A38A870D" modified="2023-02-22" version="1">MSATVTSPTLSVRNTSSSSNNSNISVFINNKKFEKPNKLLNGHQQQADKQLNNLNNQQNMSSTPEGQQQQQQQQLPRLSDDQQHYVSDRLERVDTVRTAVRMNGTQNASSGMARSDFAPQQLSNGPHYYHHHPVIHEDVQHHHEHDDHDHHEVDSLPLFVECQPKLSSTSSTAAFMQTPSVIAASLDSGSCSPIRSHSSPTPSSPSSTTTTDPRRTITTTMTGRLLSHQGSSQALLFVPEQRRVSTISGHSVRSCPTDICHSGLKDVEDGAESPVVGAAELDRHEEEEADEFHQLLIHSPSNNSVPAAAEHVGPGASRSVSPRAQAASDAYCRMYGNGTGAESVGEQQQQHHHHLPLNQQQNRLLAVIHDRNRKTSPPGDTASGSRISSDFGRRRSLHTGAPAIAFRSTLSFAAAVAGANAGRIGGVALGGGTTARNSACQQQRRPLFQRRSSQPIIYSGAAGAASSAAGMRYTPNHQHRAAAMQQQQKAAAAADQNNRFQQCRFNIGMSGSPISVGGGGGICAGTDSGGSGGTPISCGGKISASGVPTLHGATMHGPPTSFLAKRVSWLSMKSLQDCAATQQQLQHKHASAEQCTLRGGGGQDSSGCCMAGTPASILGGSRSRNKRDSASIGAEFGGISGGGGAIACKISTDTRSNSQLGSLLQLNNSIGGGGGGGYASAAGRGGGQSDADELTIGFDPLECPDTPPMDTMSWSNMDEFDNVTLMYSKHEKIPMKDFGSEIRATMDIDHLLNKAVLLLDLQETSLEEIFAKIIHEMDIQEPEFTSEQVRSVLFTQDAGNQFHILSRTVQSICTTGTVGGTFDYDQTWICALCMLNTVQHRHVAIARLSHPTNLGRTMQDLRFIIIVIAPSRAKGTKTALETTRTFATLFADMDIRQRLVMANTVDMFRATLLEAAKELAMEQSQWRDRKTSNPISAFGLGKFFPFRGMVEDLKRRKRHYVTDYLDGLRGHRTAQKMFSSIIFLYFACLLPAIAFGVLNDDNTGGGINVRKGILAQAIGGIFFAVFGGQPMIILLTTVPLAIYIKVIYRISEALGYDFFAMYACVGLWCQFFLILYAGTELCSLMKLATRSAEEMFSLFIAIAFTVESIRAIHTSFMNNYEVCEDAQVVAEKAELARRHQQMNQQRNLSLLQKIINPELHHNFTQVHYSDMSCHRDTSILYLLLMFGTLWLAMFLYNFRKTPYLTRSRREWLADYALPASVLIMSFVGAYSFSEIDKDMFKMRPDVPLFRIPEFWRLSWQAILVCFLLGFFLSFLFYMDQNICSAIVNNGQNKLKKGSSQHLDMFVVAILNMFLSIVGLPWMHGALPHSPLHLRALADVEERVAQGHVHEVIMNVRETRLATLVAHLLILGSAFCLLPFPLQWIPTSVLHGLFLYMAFTSLTGNEMVERLLLLITEQQAYPPTHYIRRVPQRKVHLFTACQLIQLIILCAVGFSPYPFIEMVFPIVCFCFLPIRHILIPRLIDYKYLDALDGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7R4</accession>
    <name>A0A914I7R4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED19</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7R4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7524.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7524.t1"/>
        <property type="gene ID" value="Gr19_v10_g7524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536">
        <property type="entry name" value="LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7524.t1"/>
        </source>
    </evidence>
    <sequence length="487" mass="55681" checksum="F173711DC0083E1A" modified="2023-02-22" version="1">MEQQQQAIAAASGISSGFLRTKISLKGSQSQLSLVYPFYGMKPELPPQSQLLGSDDLISLFDLSGAYNRYCGAKKPREDLASFLPHVCAATHINKKADSQCSLRKLIEDPPIMGREINNLTASQMVGFKLTPGPIPDANRFFDLPEQPTNSGGATTAFLPHSASAPQFEPSTVVDDRRQRKRIKRSLDELTLEDADRKAKRARGGEESGGREKEKKKKKEKKRKKKDKEKRVEEETVKRIGGEPIKRETLVIIFRRFVWDQKILNLFSSPFFVSPSGPMDSLNREIRDQVRESSWRGFYGDSPHATFSDIVTKSFDEVKKTGRNAGACRFYDMYHPEIGILRKSKSYSALAPTNAMQLKDRRVAPDLRPYHPYKPKQNEWKTELEKVHHAVHAKPKIAPLPFLPPLPPTSRRHLPVPADATRFENFCVYWGGRARGLDYSEPFLYEPHRDNYNIMEDRRYHRLYWAQHMIPSQPSARHGRQIMLTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I903</accession>
    <name>A0A914I903_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I903"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8009.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8009.t1"/>
        <property type="gene ID" value="Gr19_v10_g8009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8009.t1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55041" checksum="AB8D8AA399EB9290" modified="2023-02-22" version="1">MVSKACLHIPITANLLISLKQSSQMYLKSAWMRRHGNGSAQARNELHLNSKRQAQHPAVTLQSVEPFNPNHRRYRTCCCHAKSFTVTFCIIELFILCFIMVAIVPDFNTKICGPFAEDGKRDHAQHFETVQAHVEQQLNDNPSTMSTVTTGVQIIARQRRQITTNEAQQQQQQQAVHDEHQQEVQPSSQTTPMVDTGGPGIAFAANETGPENNSLHLLHSVTCSLTTVWLSWAFTQMFAIVLLCYGIRSQRWQMMIPHIVARMFCALAVWLVIICLIGAFARPGSLHMTGHLILVAFLFILLLWIGLLLKSEIRCAEFVKRSAETGFSVCRTRPIGPPTVSQSDERVRERRAESANPWTKSAGAKPIQTPTNVYQREKPQAKNQSVVTEMTVVGEPDAVAAAAHTRPSTAGSSNIVDNTMPNAEGAPNQQQQQQQQQLEMYQKHLDMGTTNNIQSHSANLNEETTFGGLQQSMLAKRRGRPTGLPPLRHTFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I969</accession>
    <name>A0A914I969_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I969"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7862.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7862.t1"/>
        <property type="gene ID" value="Gr19_v10_g7862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7862.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9752" checksum="805EA4204F0E5751" modified="2023-02-22" version="1">MSEYSKALLSQDGDYRDREVQGERTVAVARLFVLADAAISLAVLSLSLPFSLPLWPLVGVIFLSALYAFRRSNPTALRPMLILLVTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9I6</accession>
    <name>A0A914I9I6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9I6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8535.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8535.t2"/>
        <property type="gene ID" value="Gr19_v10_g8535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="560"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8535.t2"/>
        </source>
    </evidence>
    <sequence length="1020" mass="110852" checksum="9CFB50C1400BD810" modified="2023-02-22" version="1">MGATLSACSAAGCGKRCADQLGWIRSDADEPACSFSAEVYKLSADHRHWLKVHPKVLSLRVRLADVAVANDQHQQQQQQQQYQHMPGIAASGGVALLEAVGLVDGRRAATGGEEEGTTDRQPGKCSAGADDEDDGMQRRAALFTLPISEEAELKRYTEKFVYWRDPSPEAPVFGLNILSAAEADRFCAALRHLPPTPFLVPKWHRDEIVFDAHMAPLMTVHRGRLEECPTPLFTRCRVLLHERNATIGLTDELGQHVLAKTSTTECIFCLCPSPSSAMGGCGGVQLQPHRHDHPQLLSVSFPDRALLLQLPTRAQQLALCRHALRASAAAMAGAAVGGAAGDDDTARVARILRARLLALGRVMRKLNANDQTNGLIRVPERVEQEPVLLCDCEPAVAMRRRRAMFALLKYAMSTRIAALCDDAANKSANGGNNCSSELDKMLSSSHHFFPSPQNANAKNAIHVAHRVHLRAVLSCRRFSLQRTVQLLAKWSQNDDEWGKDGEEEEESGGMEEKEEEEEEKVKGTEEQQRRPHNQSEFSQIELNSRPHPLPSAGGSTPAQQLVNVLLELVESEQVFVHDMQTLLSLFVLPSRLSSLQCVRELCRTHRQFLGSLQTALGPSLWPPPSSAPSPEEANGKFNRQKMGAVLSRVGALFIAKSAQFKVYSKYTFAHSHFQRNREADADFNCLMVALSAPLGGTHALNSLLIKPVQRLCKYPLFLEQLHALCPPPAAVAALGGKTPAAECASICLKARAFFCFVLLLKAIALRQMRILANWLNEMVRIQEDYGAELASSSASTTTTNGATTIECEAKVALPSIRNALISDDKQQSMNGLNSLLLFSHVRWTNPPASSSAADDDDDQRQQLSGAAAGAAASSSCPSLNCVLFVFSTSIVVLERKRPKQQPANNRSSSSNKRLAPIVLPIARVLLSLIATSSSASGAACSSTTSSFVLAILPNPSSVPNTSSAPAAAHFLRFECFHPAVCRHLAQLLQHQTVTTAMAAAAADDGDEHPSMNDRMYEGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9S9</accession>
    <name>A0A914I9S9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9S9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g793.t1">
        <property type="protein sequence ID" value="Gr19_v10_g793.t1"/>
        <property type="gene ID" value="Gr19_v10_g793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g793.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18668" checksum="D8E581AB388AFEA4" modified="2023-02-22" version="1">MTEKQPRKRQKKNELFGLKSSNTSSDNGSQKFMDFDGKQCNKLALFAWKSPIFMSSSKRIAFCERPGASVANGAQNGPSAMSKCTVGVDYEAAFLSPFLLDIHPCAYAVQSDLFCALPFPFITKTRLQEHKNNGSNTKEKTRRSWNLLPDPDFLAQCVPGFQQNFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBD4</accession>
    <name>A0A914IBD4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prospero domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBD4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g838.t1">
        <property type="protein sequence ID" value="Gr19_v10_g838.t1"/>
        <property type="gene ID" value="Gr19_v10_g838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.500">
        <property type="entry name" value="Homeo-prospero domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023082">
        <property type="entry name" value="Homeo_prospero_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037131">
        <property type="entry name" value="Homeo_prospero_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039350">
        <property type="entry name" value="Prospero_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05044">
        <property type="entry name" value="HPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51818">
        <property type="entry name" value="HOMEO_PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Prospero" evidence="8">
        <location>
            <begin position="644"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g838.t1"/>
        </source>
    </evidence>
    <sequence length="804" mass="88513" checksum="7B21DB117A1789CF" modified="2023-02-22" version="1">MSSSLGNEHNNALNDDKLTYNNGLHTFDQQQQQQNRRSENRDDVDGGGEPDDHGDEDRMEQLEDEDLLFPPSLVCWSRPTQTARKCGDPSFPTSTTSNSHSSADCGEDDERQQQGGENMFEQIAKLAGLDSLENGANSNGTFNGQCERKELTQSCNDDDNDDDGVELKNSNNWTPSSSSARRKSFNPMRIKEDPPMENCAAAEAEDSSVKHHSHVFIKRLDEGEEGADDEQMGPVQQQGAKMDLFMDSNHSGVSTSPLNPFAYFPPPLFPLEADEEESGGQHRKEDATLQKQQQPNLGYFARFLKNELAGACAGAVDKVVGDFSTSSSSSCSNRSSADNVDEQYTQQQHQTAAVQHQQHLQAVHATRLWTAALALAATRQQQQHLTTEQQALAAAQIGACRTQMPPFSLSSTTTMPPPTSRGMPTTPASAFPWFSVPSMSMNAAAAAALYTTAQQHPLISTAIGAFLANAVQSATSSASVRGGGGGGIFPPPPVPHPSSVPAAHTLADQQNLNSSGCSTFSMPNFASSQNNGLQLQHNYPLRMGLRSSADCDDSPRKKRAKVTDCVRGPRSSLHREFAAFPANTPRTTPANAAATVPTMVPSVEPHARLLAYRCTGKSPIDGGAGGRTEVSSGDELAVPISPHRTTLTHMHLRKAKLMFFYQRYPSSSLLKSYFPDVHFTKHNTAQLVKWFSNFREFFYMQMEKFAKQALAEGVKRADEIYVSTESEVFKQLQQHYNKNNAFQAPERLLLVIEETLREFFNALKQGRDVEPSWKKAIYKVIQQLDEPIPEFFREPQFVELLEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID23</accession>
    <name>A0A914ID23_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ID23"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8789.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8789.t1"/>
        <property type="gene ID" value="Gr19_v10_g8789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8789.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="35360" checksum="4D3C2E6FB4FD1949" modified="2023-02-22" version="1">MEVSLKEQLSDIVNELESVTKQILQNLFADVKRDVQEKSPDEQLKALIDSFNDKQSKLVILLKNVPAHQQRQRHIRSLQEGVQRRDGIIGRLADQIKSIEGSVIEATYQAEKKLKSVKQSEMNRVFSEDVIRFAHQISKNHSVASSVYWQQGDPSRPYPTEANFALSNLLLSRTQPNVPLTFASQTASGGMLNPRLAMFGANMGASTSSASPRGRPSGTGARMASPSTRPKILQRSSSQQSPRFSQLGGLPGQQQPSLIQPSPNSLSMVQPPQSSSNFVSPGGQMMVNLPTNLKPPAPDVQKVEQMSSESSSSSSSGDEASPSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE45</accession>
    <name>A0A914IE45_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE45"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9772.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9772.t2"/>
        <property type="gene ID" value="Gr19_v10_g9772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="417"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9772.t2"/>
        </source>
    </evidence>
    <sequence length="622" mass="70691" checksum="0E986518A5D10C7D" modified="2023-02-22" version="1">MSISPKSTTAGDITADQRNLGSTFSNLEPSEQVRILLARIAELERQQSTNSPTSSASFDLLEAAADDRGKIAAEHGGGNESAAAKDGQQTNTAQLEEELHQMKKELKNMKESFDKKLEEQMGALQTKMEKYQNKQQQTIDSLTQKLKVSIDQLSLKHQEHEKLLNAHKNLMEEKIDWLNDDQQKLVSIDQFLLMQSDQKALLQRLNALEQKLMNSEQQKTDQKALIVMEERVAKLELKNKELRAEHEKLSTDHKNLKEEMKEQREMDALKQQKETNHKIDSLIKDQQQQIANMIRKMEQKQKDAQKEFQRKLDESLNGQAMVVAKLEEQKQSNANKFAELEKQKVSNANKFAELEKQKQSNANKFAEIEQKNDKLEQYQNEQQLNIIDLQKTVATLTETGLIPENRWDFDDCHSSLALSELDRFAQYNGENLGLIPENRWDFDDCHSSLTLIGAEQLIVQYNGEDWGWSSVIAEKTMPENPYGISYFEVTILEKTTGSILIGLATKQMPLDEFVGDYEETYGYGSHGIFLGHEVDGCRHRLLSGRPYIGGNPKFGVGDVVGCGVNLATYQIIYTLNGELLYTDNLFVESADDLFPCVSLGRPGTKIEANFGPNFQFNISDEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D1FNJ9</accession>
    <name>CL4A1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName>CLAVATA3/ESR (CLE)-related protein 4A-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CLE-4A-1</name>
    </gene>
    <organism>
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Mol. Plant Microbe Interact." volume="22" first="1128" last="1142">
            <title>Structural and functional diversity of CLAVATA3/ESR (CLE)-like genes from the potato cyst nematode Globodera rostochiensis.</title>
            <authorList>
                <person name="Lu S.-W."/>
                <person name="Chen S."/>
                <person name="Wang J."/>
                <person name="Yu H."/>
                <person name="Chronis D."/>
                <person name="Mitchum M.G."/>
                <person name="Wang X."/>
            </authorList>
            <dbReference type="PubMed" id="19656047"/>
            <dbReference type="DOI" id="10.1094/MPMI-22-9-1128"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Mimics host plant CLE extracellular signal peptides that regulate cell fate. May play a role in the differentiation or division of feeding cells (syncytia) induced in plant roots during infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host extracellular space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cell apoplast</location>
        </subcellularLocation>
        <text evidence="1">Present in secretory granules within the dorsal esophageal gland secretory cell and in the dorsal gland ampulla (collecting reservoir) at the base of the nematode stylet. Secreted into host root cells via the nematode stylet to transform the recipient cells into enlarged multinucleate feeding cells called giant-cells or syncytia. Secreted to the host apoplasm from its cytoplasm via a plant secretory pathway (By similarity).</text>
    </comment>
    <comment type="tissue specificity">
        <text evidence="5">Highly expressed exclusively within the dorsal esophageal gland cell during syncytium formation in host plants.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="5">Strongly up-regulated during root colonization, from the onset of syncytium formation by parasitic second-stage juveniles (pJ2) through the J3?J4 molts of sedentary life stages that become adult females.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CLV3/ESR signal peptide family.</text>
    </comment>
    <dbReference type="EMBL" id="EU386831">
        <property type="protein sequence ID" value="ACY70450.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EU386838">
        <property type="protein sequence ID" value="ACY70457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1FNJ9"/>
    <dbReference type="GlyCosmos" id="D1FNJ9">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043655">
        <property type="term" value="C:host extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044962">
        <property type="entry name" value="CLV3/ESR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36349">
        <property type="entry name" value="PROTEIN CLAVATA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36349:SF2">
        <property type="entry name" value="PROTEIN CLAVATA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0221">Differentiation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5000539260" description="CLAVATA3/ESR (CLE)-related protein 4A-1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="A-1">
        <location>
            <begin position="127"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="CLE-1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="A-2">
        <location>
            <begin position="148"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="CLE-2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="A-3">
        <location>
            <begin position="169"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="CLE-3">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="A-4">
        <location>
            <begin position="190"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="CLE-4">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="A-5">
        <location>
            <begin position="211"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="CLE-5">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="A-6">
        <location>
            <begin position="232"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="CLE-6">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for secretion from the host cytoplasm to the host apoplasm" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="6 X approximate repeat A">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="6 X approximate repeat CLE">
        <location>
            <begin position="136"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="19656047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="252" mass="27790" checksum="EF378AFF1DE8E3A1" modified="2010-01-19" version="1" precursor="true">MAKNAMLCLLILRVVLALAFATNKKGDEEPENHSTGIFGKVGRVVTVALAMSSRLGGADATRGGGAVYGRDLKSNQLPNNNWMAPPPPMAIRSAKVYDSKHSPAEYLKKFAQDFRRKTGMHSQRHHEETTLEQEKRVAGAGPDPIHHQDTTLEQEKRAVPAGPDPKHHEETTLEQEKRAVPAGPDPKHHEETTLEQEKRAVPAGPDPKHHEETTLEQEKRAVPAGPDPKHHEETTFEQEKRGAPAGPDPIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQS4</accession>
    <name>A0A914GQS4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQS4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10535.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10535.t1"/>
        <property type="gene ID" value="Gr19_v10_g10535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10535.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23554" checksum="7C6B956FAAF168D9" modified="2023-02-22" version="1">MAINMSDKRGLMQQILGEADICVTSTGITISGPRLSTPRTIPFEESGKCRSCKSTEVELDTMITKEGVTIWCSRIKNTQFVPFDVIYDLPGHCFFRVKNKARVFNVPYGDPNPVTCDSQETETDQQDLKRKAKVALDLVEAGLMADAMQDGSRWKKAKTAINLLGNLLLADTLPPPPTLPAPPPIEPQQKQAEEEEAKLQEFYDSLAATTSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR38</accession>
    <name>A0A914GR38_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GR38"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10617.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10617.t1"/>
        <property type="gene ID" value="Gr19_v10_g10617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10617.t1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45716" checksum="CF8C23BAAABF4986" modified="2023-02-22" version="1">MVNKSMAHAYSESFICFVMGEGIGLDALSREVIQKLMRVAQFRELWADLAKQSQNLEGNLGESEATKGRSDWTKMTRRGRSAGPSNSDPRGFVAPNVQFHQNRHKTATNPPNLAGKFIADGLQQLVQAICMAVDAFRHGTQLARFEDQLSSTRQSVDSVALYMAHIRLERFCASDDLHVGKFGLAARQISNLLRAFTQRVSSTYSVERCSFLADALFRLLTKFYECIRWHQRQSANANDTNKFGKAIQKFGHFVCHALRKMLTMKHLKTQRLADVHCQRLFSVCPPSGNERLLTPGALSLARVALPVLLDGQIVRIQKRQRGFLLSPELAFNRRRVAVAHSSDNWGNERTKIAKKDASSDNKRVKISRDSLRSAGPAEIAALREMCKLTLEYIEEVTGNRNDSAIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR93</accession>
    <name>A0A914GR93_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GR93"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10564.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10564.t1"/>
        <property type="gene ID" value="Gr19_v10_g10564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037034241" evidence="1">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10564.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="27804" checksum="7600C4F9E364CA5D" modified="2023-02-22" version="1">MSLFFLIFWPGGISVRAQNAQLQAQAAAEAAQNAFMQAQAAAAAPSGSSDDNSGGGEGRVFLHLGWSQWQDMLCNFWRREGNCLLFEQRRWCGMIPEKAQTLAQATADLIRGGSEVSKTALWGQLFAMDSGHLPATIDTSVEFQTACRAVSFRILCEGKETLLDFLIDAISSRHASAVTNAGLFLANTPGLVGLVDTADRGDNRPLGWRVMAEILTNYRFHADLNATLAKLLPKLRPPCHNIDELMDRGAPYGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU61</accession>
    <name>A0A914GU61_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU61"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11257.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11257.t1"/>
        <property type="gene ID" value="Gr19_v10_g11257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11257.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="25329" checksum="B2E7180C860CE026" modified="2023-02-22" version="1">MDGLLRGWMDCRGDGWIACGDGWIACGDGWIPAGMEDLLRGGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIACGDGWIGANGAAMVEIDSNRRHFIGSSADFLCPLAHFLAFHWRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV02</accession>
    <name>A0A914GV02_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GV02"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1103.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1103.t1"/>
        <property type="gene ID" value="Gr19_v10_g1103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1103.t1"/>
        </source>
    </evidence>
    <sequence length="735" mass="80103" checksum="102A07D4B77601CA" modified="2023-02-22" version="1">MDLRAAAAVEENGASNGGSSSTSTSHVGANVAAGTQYSSSAPSTFNSFQQFQQQQQNSLDEPNSSRRQSAFSNNGSPSNDQQRNQNTFKADAAGGDVSLTSRLNAFRLKDVGCDVAFVVGEEKEQLKAHKLVLGATSAVFYAMFYGPLGSALIGTAIPRIAPEVPQIVHEPPGAERCTAQAGGGGGGQAPQSSVGIKQPAAAAAAEEEVGDEYYEEYEEDEYEEAEGHEEEEPENMSGDGSYSNSLASSLEGEHHLRDPHKVFTTPHPPAHAQHNHQQRQPQFPFDGKRHFSNGFHAPPAKLGHKTVQAIDDHQLASELAARGLQMICAPDCEPKAFAILIDFVYSDFDVRSLSVRGQLTDDNVMNALYAAKKYAIDALVAECVRYCTARLTATNAVSLLAQARLFDEGTLVEQCYQMIDQNTDVALEATNVADIDRNTLINVLGRSQLDPSSELIIFNAAKAWAEAECSRRSIDRNMENLRKCLGPAMQLIRFSLMDVNAFGVAASSSLLTCEEIAEVFLHLTVRPRPQCRFSSRGFRANSRSKHTVQRFSTLSSKRCTRRENKICFTADRDVLISGVAIYGANQAGSRMIADENSAKTSWEHKVAIKLELVADLYGSPLELLASNEILVSGTFGDPTPFVAHFSDPVPCLANTTYLVTARFMTEEGVSTFQGKEGQAVVSVELPFDQTVRFKFQAWRNGLWNDDGGRTEGQIPALHFLIQWPEEANEAIKNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVX9</accession>
    <name>A0A914GVX9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVX9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10897.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10897.t1"/>
        <property type="gene ID" value="Gr19_v10_g10897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037846502" evidence="1">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10897.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15329" checksum="C715C84F7E7946A5" modified="2023-02-22" version="1">MSLITALLIVALAFLAGNVHQSEASCCCHCCKCCSCCTPCCNPPLLIKLPRTCPCCCKCCCPCCCCGGGNGRRKRRNVRMLWKRSVPFPQLQLPTLSGCQKWPMSASTPCNSCEQHTKAATKRDIVNLKDFMFPSLTKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWI7</accession>
    <name>A0A914GWI7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWI7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11048.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11048.t2"/>
        <property type="gene ID" value="Gr19_v10_g11048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000005">
        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000034">
        <property type="entry name" value="syntaxin-binding protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF40">
        <property type="entry name" value="LD27118P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="241"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="368"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="639"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="761"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="914"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11048.t2"/>
        </source>
    </evidence>
    <sequence length="1149" mass="124140" checksum="885305AA887D3E94" modified="2023-02-22" version="1">MPNLGHFYALQNPAFTQPPPPPPQPSSSLKMVISSPTAAAVAATAAAVSGRPLPPNWEISYTENGEKYFIDHNTGTTTWDDPRDTYPHHQQLEMAAALAEGQQQQQQQPPLLLPDGWERVDDERHGTFYVDHINKRTQYERPTSLIMPTKQPIYDPYQHQATTSTSPNGLPQPLQHQQPQADHHGRFASMSGILSSDNGGIYGTYHNGNYASHQHHHQNGVGSAHTQFTRNPVELRGEILSTRIQKGPKGLGFTLIGNDGTNLHEEFIQIKTIIANGPAAGEGTLRSGDVLVTVNDRCMLGASQDDACQVFRAINVGEFVCIQICRGYSLQMDPTNRIFTENVYASNTTNPQQFNNQQQQQRLRENHVVQLCKGSKGFGFTVYDDAFGQRVKSILHPDQCPNLLEGDTILEVDGRNVRALPHPQLVQMLHDFPLGYRCKIVVQRRAPKQRSRTPTAGFRYGYGGGGGQASASVDSRQTQQQQQQHRPLFVQRSKTPGPSAKSNQQQQQQQRQSMYHQQQPQQQQPQLQQQNWPNGSTTLPRSLQNRNTATGNNGHLQPHNDGGHRAHNFSSSSAVDTVALPPPAPSAPRMRPSSSTLGFCPTPAFVPISALNGGGGGGCAGAQNGTPNGTMNGRKQSIVVNLISQPSGFGFHLLGGAEENKPLSVGAVIAGGAADLDGRLRVNDQIVKIDVHRVEGTQHNHAVELIRQAAIVGHVRLVLLRDCCPSGVGGGGEFSSHHSPATTGSAVGSQGSRGNEFMPYDVTLVKLEGEPDFGCTIISHNHRYIADILPGSAAQRSARLRVGDCVLAVNGHSVANMSHQQVLQYIRSNGNTLTLSIDPALRMMDPSDASGGIQNYAAPPPPQKSSCSDYGSIGGGGGGYGTVVNGGGGGTVVQQQQHQQQQRRNLPPTTNVFFVELRRGERGFGFSIRGGAEFGMPLFILKIADVGPAAGSAMQIGDQLVAIDGESCIGMSHERAIGMIKERQQGEKGKGRAHQLHGGDRFSAHTSVPCTGTEVWALKCASLKREARGGAPATVYYPSLPRCAVGDSLALTRLKRSADKLRCGGCEMRGHQQKKTEGQGGNDFNKYARNCACLCCGCSMHGVWESMNWSTSALAFVQPRSTARSFCFTTRQNASSSLSDYGGRKLFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXE1</accession>
    <name>A0A914GXE1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SP-RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXE1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12081.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12081.t2"/>
        <property type="gene ID" value="Gr19_v10_g12081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF94">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="5">
        <location>
            <begin position="45"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12081.t2"/>
        </source>
    </evidence>
    <sequence length="263" mass="28740" checksum="4EE358E588DA5B54" modified="2023-02-22" version="1">MMAAAAASNQHSDILLERILANPNARHPLEKTKQTIIRRFNGSDEEDDVQMDALKISLIDPLMHTRIKIPSRAVECTHLQSFDLNSYLMMCEKRPIWKCPVCNKSAIDSKLIIDAYFEQVLSNVGAGVNEVELLRDGTWRLPQAKAEVSFALDEAANAAVEGGASGVNAAGDNDDIVVMAVLAGAGRCNDNQQQQKQNSSNTAAEVVLALAQPKRVPSATAPPDLDIICLSSDEDEDLIQIVNENLVPTIVWLSFNENQNSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXX6</accession>
    <name>A0A914GXX6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXX6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11802.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11802.t1"/>
        <property type="gene ID" value="Gr19_v10_g11802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037816389" evidence="2">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11802.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44854" checksum="E5C35C8C92E9F492" modified="2023-02-22" version="1">MQSIQQLFLLLLFELLCAAFTTVLSQKDCGLPTNLRELPNFAQDELRSVWRDYVPGRRCEKEQLITEDILTVLDMFDKELMPRGTVKDDTKPSPTGLESLLNKELKQFEAVHGCFQQIGHAAPIVPSSPRANQTLTTTTTTTTTSDQTPSPPASTTIKAIASTHIEAVPASTKVEQQQQQRLLQKDSKNAEIPMSDRAQRPGKFPSPHSVDYELDTGSGISEKQSPEDIVDAVRRPQKQKISKDDVEQGVEEGQQLLGKANDAEQFESDKQLLPFLQEASTDVVQVFMEVMEDPDIPSERRRLEELHLLAVSYLNAHQLDEYNRWSTTRRKRIQSRERQLHNLSPRARDALRQLALTTDVRQARAQLRRIEPALRDELQSWGKSRERAVALVARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYJ4</accession>
    <name>A0A914GYJ4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vesicle transport protein USE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">USE1-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYJ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12370.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12370.t1"/>
        <property type="gene ID" value="Gr19_v10_g12370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12370.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11278" checksum="178E9ACDE194E7F7" modified="2023-02-22" version="1">MEQEEKQENLSKELLRLTSSLKHNFTAAGSVLKDDNLALDAMQRLALSNKENLIRERGRLRHHTYQSCFNCVMIMTVIVVIWSFIAMIIVMRVFPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYM3</accession>
    <name>A0A914GYM3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large ribosomal subunit protein uL18m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">39S ribosomal protein L18, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12394.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12394.t1"/>
        <property type="gene ID" value="Gr19_v10_g12394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16574">
        <property type="entry name" value="RING-HC_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000005">
        <property type="entry name" value="39S ribosomal protein L18, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058746">
        <property type="entry name" value="Znf_RING-type_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037088582" description="Large ribosomal subunit protein uL18m" evidence="13">
        <location>
            <begin position="17"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="404"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12394.t1"/>
        </source>
    </evidence>
    <sequence length="674" mass="77190" checksum="D5AB5E06971D0E24" modified="2023-02-22" version="1">MLIFRNQILLFEFGFGAHLLQCTKEKVPRTMLLSSTAAEPPNKRMTCPICLHVWNDPTVLDNCPHIFCFECILEWTRLKPECPLCKRGLLSLRHRLLLFGGEMPSWKSKGQEESIIRLRSEYELDQILTRTSYPPDVEQHQVELVVKHLMLEIGALRTISMRGALASQSIYREAICGVERELDDYRMLLSKFNNGATRAQLFKEHSFRRVVYLNNLTPRSICPSMFNVVFNAEYVSGNRKIVWSQIVYFVIREVAALTKKACVDIDVYMDALLDYLSSKINRTEIVIFLKRRDIQNPHHFLNNLSHFASSGQTLEVYDQNSEYSSRRSGILLGNDDDVLVLNNGDDVEVVGERRRRLARPNNVQDRHPGVLERLYSYFNHFARDSQSQQHEQLQQFGSWRPPAGAVYGAEATGPSGSTVSYPPQLPHSSSRMGARPPLSPPRALATSSTVTLDDDSDDAEDAVEFVQEIKRPKSLHNLEEEESEEDEQMDDDMNRATFLQRFVNNNPRNFERVRLQRKPSGWGFEKNNAQRNFIYRVDFCPTKNSTVASVVHYEDGIVIEASTREKTVQSQLYSQTDVSAAYNIGRLLAHRCKMAGIEHCVSSLTEEELEGSKRREAFLRALEESGLVLEEPEPIPHTHLNDPNRVWESFPLRHDRADKLDELDLSMEPGKGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYU8</accession>
    <name>A0A914GYU8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYU8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12052.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12052.t1"/>
        <property type="gene ID" value="Gr19_v10_g12052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018614">
        <property type="entry name" value="KRTCAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF7">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09775">
        <property type="entry name" value="Keratin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="272"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12052.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="36124" checksum="E2B3F1B5679FC41A" modified="2023-02-22" version="1">MAGSNGFSALLSLLVVLSCIIVGQSFKALLAESRQGNLAAGGLGSVVFAFTLTAISNLKMANAGPSAKCGLFECGVALFFGVLSSASIHRISITICVLFSAVLLFFLTGISHKRYDPSGDLSTTTAGGGGKKRNDGFSSIGDNNLFDLAKDSTTIEQKRNGEDCSSDAFCARSPLSPPCLKCDFPVDCSLGEPISVNCTLANCGHSRRTVQLQTKCRFCWQLEQSEIVCEEMKNCSTNELSLHRTTCRAKSNVICAGRRTFFRNVRCHWTSGHSWSKALFLSVTLGGFGVDRFYLGHWKSAIGKLFSFGGLGVWTLLDIVLIAIGYIQPADESLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYV3</accession>
    <name>A0A914GYV3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA ligase</fullName>
            <ecNumber evidence="19">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12454.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12454.t1"/>
        <property type="gene ID" value="Gr19_v10_g12454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="874"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="23">
        <location>
            <begin position="402"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12454.t1"/>
        </source>
    </evidence>
    <sequence length="1068" mass="121692" checksum="8D60ED976DBAEEA2" modified="2023-02-22" version="1">MVLTRFDLKDVYIFSFSSVAAFGIGRPTINRMASIEEVIELTKWRDGQKIPYLALAKTLERIEATSSRLEIIRILSDFFAAAICISPSDLSPAVHLCVNKLGPSYEGLELGIAEAYLIKALAGATGRTVDMIKKELKTKGDLGIVAQQSRSNQRTLSKPPPLTVPHVFNRLREIAKMAGTSSMDKKVKAIQALLVPCVECEARYLVRCLQGKLRIGLAEQSLVAALANAFTTMELRAQKKKLSGEKLKERMVEDVQKLKTVYCECPNFGRIIEVVLRSGFASLTDECRLTPGIPLKPMLAHPTKGIQELLDRFGTAEFACEWKYDGERCQIHLLLDGTVKIFSRSQEDHTGKFPDVVRRIPDALNKKVQDFVVDGEVVAWEPKQKQILPFQVLSTRKRKNVGDDVEVKVIVFLFDLLYIDGQSMTGETYRTRRERLRKAFTEVPGSVVFANSLDTQDTEEIQMFMDDAIRGNCEGLMVKCLDENATYEISKRSRNWLKLKKDYLEGVGDTLDLVVIGGYCGTGKRTGVYGGYLLACYNPEAEQYESIAKVGTGFKEEDLKNQHKELQELRIDKPRSYYAFDPSMAPDHWFKPALVWEVKAADMSISPRHLAARGLVDEERGISLRFPRFIRNRPDKKPEDATSAEQIADMYRNQDHIKNQMNGNAADEEDNTLDFSRGVPSSVPSGAFHPHHFVGSTANPCAQQPSGTATFLHLGQQLPSSTNPSAGQFLLHQQQFQHLQQQQQLRQETAEEAKRRFEIECEFVQALANPHYLNYLAQRGYFKEEYFVNYLNVCSFWRRSKISSCSNGTFTSEFDNAFWRTRSRCSNNNANANCLPTRQLSSLAPCRDYYFHPPPLPRPPSPPHPKSRQQRFRLLLHFLFFLFQIAMFLFALFHLVPHHSSATTTTVDDFEQYMPTRCESCQLFARDLDVNARRLATKMSRDQAEAWLIDELEQLCVRMLDFRLHKDRRGLARFAKERTGTVNAIKKLKERGVQVKLDVDDALLDRPSVESGRLKEHCEWMIEEFEQDIDQWFIHHRHKTPLEAFLCAGRLADEFDGTCAANIRREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H096</accession>
    <name>A0A914H096_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H096"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12432.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12432.t1"/>
        <property type="gene ID" value="Gr19_v10_g12432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12432.t1"/>
        </source>
    </evidence>
    <sequence length="879" mass="99586" checksum="A2D35C3D29B88D0C" modified="2023-02-22" version="1">MAPLNERKIDLPIIFIVGGPGCGKGTQCERIVQKFDFTHLSSGDLLRNEVNSGSELGKQLKETMDAGGLVPLDKVLAIVKAAMLKECETSKGFLIDGYPREVIQGQQFEQEIQSPVLVIYFEASEATLVKRLMGRGRSDDNADTIKNRLRNFVESTKPVVEYYEKQGKLVKIVAESSVENIFAEFHSDQQATKTMETDQMSDKEQMEQQYPGWPHAYRELANMYLFEGVSNDFPYIASSPVSPNAYLVPTSIGYVASLLKMTKSQRNKAEHLKHGSPTSSPGVSIGLHRKTPVRVIVSKDPNDIIVKQLIYESFNDPSNTIKMDKDGIVTYCLFSDVRVPTKCYVSGYPNAEVAHELLKGTEWIPNVVYEGRVQCKFTWHMDEQTRRVKNLRGHFQFNKIVGFALRNEDLRAYNSLAEFAVRDKLPMLVPVRIRAVSMWYFRDCPVLAPDRPRRLARISPGLSVDCNLPSFIEIEPDVANRKRPLPAIRDGQRIIANLWHNRLNNFYLVLSYVLADRHRQPGERDDQYQLTNRLQLATSSAAETTNQFLVKVNNSIFKDFYSCEPLGFALISDPKRLLRNASPAEHLGGFPVWICVEADEQRLARCRITALADVSTNYSRRDRSGLHPDIRGHGILIVGSKGIVFSRDHPQTRVRLLPSDRCRVSVGEQFLFSATFYGLKKGFIVCGIQRLNEQDDDYFEEIESFHFGGDDILFVQELRTHMRQWAAEGHDSPNFGPVADPGELVREYVHRNEINWPELIDVFVCYNAGWVPGESTLMKVHSLLDETDDEVINNMIKSKKNRKKTDAQGTVSSGHSSCPASSSSTDDVEDECECLQKWSILRELTNEEQAVNQLEPELVYRLVELRNAFSSLIARTVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0P3</accession>
    <name>A0A914H0P3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0P3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13094.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13094.t1"/>
        <property type="gene ID" value="Gr19_v10_g13094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF14">
        <property type="entry name" value="EXPORTED REPETITIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13094.t1"/>
        </source>
    </evidence>
    <sequence length="587" mass="64858" checksum="5C417CCD2EBDCC0C" modified="2023-02-22" version="1">MFEGPGSEIGRNGGSAKLAAQILRPETCGPNFAARILRPEFCGPNFAAPKLAAQILRPRNLRPEFCGPETCGPNFAARNLRPKFCGPKLAARILRPEFCGPETCGPNFAAPKLAARILRPRNLRPKFCGPKLAAQILRPETCGPNFAAQILRPETCGPNFAARNLRPEFCGPNFAARNLRPEFCGHDLRPEFCGPDLRPEFCGPETCGPETCGPNFAAPKLAARILRPRNLRPRNLRPKFCGPKLAARILRPRNLRPKFCGPETCGPNFAAPKLAARILRPRNLRPKFCGPKLAAQILRPETCGPNFAAQILRPETCGPNFAARNLRPEFCGPNFAARNLRPEFCGHDLRPEFCGPDLRPEFCGPETCGPETCGPNFAAPKLAARILRPRNLRPRNLRPKFCGPKLAARILRPRNLRPKFCGPKLAAQILRPETCGPNFAARNLRPEFCGPNFAARNLRPEFCGHDLRPEFCGPETCGPEFCGPNFAARILRPRLAARILRPRNLRPRNLRPETCGPEFCGPNFAARILRPEFCGPKLAARNLRPEFCGPNFAARILRPEFCGPNFAAPKLAARNLRPEFCGPNFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1D7</accession>
    <name>A0A914H1D7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1D7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12343.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12343.t1"/>
        <property type="gene ID" value="Gr19_v10_g12343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="7">
        <location>
            <begin position="43"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12343.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26004" checksum="729210F1ED903378" modified="2023-02-22" version="1">MVFIPSILDETKRMALSLRLGNTHELNDRGKRKVALNDCRKLTDFPEELEHYVGRDVWTDFITELNQIYAEAKNLTTIVYLENILGLITCHLSRLCFRSLWSRKLEEAQTLLCEANRQSFVAKGVCVCNPLDKGFRVIEVVLLDEPISTQDEKQEKNVVAEQIVLQPRNNKSLSMVGGNGSEVDGYVNSVGSAKPFGQSHINGNQFLSSNISSFNARIEFAPEGRCIIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1G7</accession>
    <name>A0A914H1G7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1G7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13144.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13144.t1"/>
        <property type="gene ID" value="Gr19_v10_g13144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF34">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13144.t1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41258" checksum="3256487F3C09DE7A" modified="2023-02-22" version="1">MDPNELTQNYVRKAYADIKRRVDEEAETAKRGTGGGFSSIARSFPFVLGHLRQIAPHSLILDIDSFTIGMDVNGAPRGKAENVDFVLADASYPPFRKGLFDAVLLVSVLHHIPNEEIRAKCLRNCLWLASAEKCRVVAVVWAKEQKAAEFSSNDVLVPYNLEDMHKLGHTVEIPFNKETTREQRIMLNAVPIRVKVPPNIRCPNYLPKNVRRRVLEVVSRVGWLYPMMSMDFYEQQLNFMANFLIDRLGKLKRIKDFSPKNISARDPRGSICEFSLKVSISVLDDAFAQLRKIYRDVLKYRYYHLFSADELERLMAKIRTTDPFGDFQPIEVEYELGNWCAAVQRCDDPKKTDERTLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H295</accession>
    <name>A0A914H295_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H295"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13002.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13002.t2"/>
        <property type="gene ID" value="Gr19_v10_g13002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13002.t2"/>
        </source>
    </evidence>
    <sequence length="75" mass="8828" checksum="77B570658345F091" modified="2023-02-22" version="1">MFFFCLQMKPNEHASDHASRARHSFAVVNPLNVLASGSELENSRKIVLNYRLGRLLHSWEETNAGRWAHYRHKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2K2</accession>
    <name>A0A914H2K2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2K2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13557.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13557.t1"/>
        <property type="gene ID" value="Gr19_v10_g13557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000018">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13557.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40157" checksum="E56D5158DDFF161A" modified="2023-02-22" version="1">MLDTRTRTRSRLVLSFPTFFEFSNPDFNFRWALLKRYDQMGEQMKLEGSLRGHNGWVTQIATNPLNKNMLVSSSRDKTIVVWTLDESGSVLTGKPIKSLHGHGHFVSDVVMSSDGQYALSGSWDKTLRLWDLNTGQTTRQFVSHSQDVLSVAFSADNRQIVSGSRDKKIKLWNTLAQCKHSIVEECHTDWVSTVRFSPSHANPVIVSAGWDKIVKVWNLATCRLKTNHFGHTGFINSVTVSPDGSLCASGGKDGSAMLWDLNDGKHLYTLGGNDVINALAFSPNRYWLCAAVGPVVKIWDLENKTVVDELKLDIASTGTNLTRISKKSCPQCVSLAWSTDGQTLFAGYTDNIIRVWRIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H398</accession>
    <name>A0A914H398_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H398"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13446.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13446.t1"/>
        <property type="gene ID" value="Gr19_v10_g13446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF53">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="115"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="469"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13446.t1"/>
        </source>
    </evidence>
    <sequence length="554" mass="61338" checksum="730BE3AAB7FE9C5A" modified="2023-02-22" version="1">MNVSGDDELLLPLLLLLLLLLLLLRIPFHFDDPTANFFAAASAIQSAGSNSRRGAQSVQLPTTMAAPWGEGRTREKEFLASLPVFDMFPLSNGDENHVILYALLYAVLFLVGVCGNVSVITLIRHLHANTFYDNTMIYVLFLCCVDLASVVPLPMAIMDQLLGFWMFGTALCKVYRALEHVGRALSTFVLAAMAFDRFLRVCHPHKKTTRRMVLVQLCLLTLLTFVLLSPLLVKSSSKELVLKEVLLENPYRLARVRIFKCMDHLEGTLLSVFISYMFIIGFFLPVLLITVFYALMMRRLFRRSRSFPTSSKLPVNRIAGYTIAISVFFVLCWSPYWVSMLYFNFMHWDSEDQERNEEIFNSDKFIYIMYGIHALPYVNSASNWLLYGLLNSQLMRRAKYTGESTYYVGGVDNGFSLRLASTNHNGTPPQHSITFRAASSSTAPLKHSSLAVMGSGRCNSTLCTPRWGGKTGRRSVSGQAVGKTNCGGSASPSMRSISTASAPPQATSAASSGTAEESADAAGECHRQKTAAGESQQLLLPRSADSCAPLDILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H465</accession>
    <name>A0A914H465_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H465"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1348.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1348.t1"/>
        <property type="gene ID" value="Gr19_v10_g1348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1348.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11989" checksum="0EEB670B22022BF1" modified="2023-02-22" version="1">MNFGSGPTKKFCQICRTWIEIFDEKVQVEKFTMHKSCFICAICDCPLQPGSCSRDDGLMYMQFMAGHRIPMWFCSAHMHLGSGEKYKLLKKKQQQYQQQQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4J6</accession>
    <name>A0A914H4J6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4J6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13588.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13588.t1"/>
        <property type="gene ID" value="Gr19_v10_g13588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013869">
        <property type="entry name" value="DUF1757"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38636">
        <property type="entry name" value="PROTEIN CBG20488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38636:SF2">
        <property type="entry name" value="TRANSCELLULAR CHAPERONE SIGNALING (X)CROSS TISSUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08560">
        <property type="entry name" value="DUF1757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13588.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26794" checksum="FA08A4A9E48DC382" modified="2023-02-22" version="1">MANTPTYNISKSEGENSSLGGWVENFFRVDLLRSSPKCLANIPNPVVEYGIYCTFKTVEFASLFGGMLARPLYAQYVLKRTPPDKITVNTTKIARAAGRKLQGQILLASLFMGPLVVFPLALQLGGCTRTELKEKCYQIRCDERTIMHDRLTLLMGFAGWYWKRFQGAVDFINGATVYTTLRFRLLSEESSNIAMKFVADDDRYASPADAELDMRQLTRFFRRSPTPNAGEGTPETNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5A2</accession>
    <name>A0A914H5A2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5A2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14289.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14289.t2"/>
        <property type="gene ID" value="Gr19_v10_g14289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="883"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14289.t2"/>
        </source>
    </evidence>
    <sequence length="1243" mass="142889" checksum="E6A58DD25279BFFC" modified="2023-02-22" version="1">MDFLPNYRISKTLKMLLRRFLILMKKLIEVERSQSSLGVDQETAPGFNFQSQPVFQPNLAPPPSSKLSQQFSQPQSPSQVDEEQSFLPPGLEEFPEAPGPAFEPSNAPAPFQNTIKVNGIGPEPPPRSVNTTTQTIPATPTTPPNRLTFCNNFNNTTKQIVCVNNSNNPCNNFNNSNKQIVNFNKLNNTNSSNNTTKQIIICVNKCNSTNNSSNNSNDYSNNTTQIVFVNNPNNPFNNSNKQIVNFNKLNHTNTFYNNSNNITTKHISYDNKCNSTNNSSNNSNDYSNNTTKQIVFVNNPNNPSNNSNNSNKQIVNFNKLNNTNNFCNNYSNNTIKQIVCVNKCNSTNNSSNNSNYYSNNTTKQIVFVNNPNNPFNNFNNSNKQIVNFNKFNHTNTFCNNSNNITTKHISYDNKCNSTNNSSNNSNYYSNNTTKQIVFVNNPNNPSNNSNNSNKQIVNFNKLNNTNNFCNNYSNNTIKQIICVNNPNNPFNNFNNSNKQIVNFNKLNNTNNFCNNYSNNTIKQIVCANNPNNPFNNSNNSNKQIVNKLNTTNNFCNNYSNNTIKQIICVNNPNNPFNNFNNSNKQIVNFNKLNNTNNFCNNYSNNTIKQIVCANNPNNPFNNSNNFNKQIVNKLNTTNNFCNNYSNNTIKQIVWVNNPNKHINTNYSTKHIAYDNKCHRCSSIYTKHYDVNKEVEKEMPKDANVPLELTPEFKQQKAKEQQKDAKADQLEKDWKNKIAELDRARQALNDEARTGAQGLSNDALFQGLQADYQRKLAEMEEAKRRKEQAQRDAEEQARKTEILQKEWKKKLNELDNARRRQEEEARASAQAQAHAAALQQKEAQLEAAKRRIAEEERRAALGQQNKAHLDAWKHKLVEMEAEKQRIEATARQAALQRHQQAKQEEWERKMAELEEEKLNQEELGKVEKQRQEEAQQAELQRQQEEDWKREMAELEEAKRQREEAAKQKWERQQKTQDAWKRKLAELEEEKRRREEADKATQPLPDWTFPPLHATETPFTVSSFNWPTQALPAIPISGGTIKDQEPLAPSEREVMEKRLKLEEQQIADLAKVLTEHQQQLTQLRQLQPPQESEPISNLEEEWKRKMSDLEEEKRRREYEAKEATLARQRVDMQEEAAKQRDEEFKRKLAELEAAKTRSIQRVVPTQSPVSVNVDELQALPSLAPAEPDLRTLTFGASQAVDKAIKKWKEIDPQVANWLNSFKGMLNRLGTDAEKYLPKKQPRVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5V5</accession>
    <name>A0A914H5V5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5V5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14110.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14110.t1"/>
        <property type="gene ID" value="Gr19_v10_g14110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038022">
        <property type="term" value="F:G protein-coupled olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF28">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037483866" evidence="2">
        <location>
            <begin position="22"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14110.t1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43646" checksum="38DBF8A6CEF0D0D6" modified="2023-02-22" version="1">MTKSLWIFQFLTLFLLLLVPSFEPAPPQPSVRIVKSPLRHSEVHNAEVQLSVLVNQGYEIAGFVGSQDNDTYDYVWTLYNFITDKGETEAIVYGLITFKGVENRIWNLLAFVCWVFLVYVSMFGYVSQFIFRYIVLVRDINVSTFKYFLLLCLMLLFPFAYCVNLFICYYPPAEHAIMDDSSVAQMLGIDLSEQIVLAGYSFNDPRQTFGLYYVITVCTLAYFIMFTLAFLIQKLLENRTKMGASSETAKKMNEMNKQISRNLIVQASMPLIIYLSVLFLVALLLFKIDTNGWNWLQYYNLFSTIPMYLPSALNPIISICIIHYYRHAIISDTKAFGKKIKHFFGLTVCQQHEQPQQQQQPEKWAISVGKNVQTKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5V7</accession>
    <name>A0A914H5V7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5V7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13500.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13500.t1"/>
        <property type="gene ID" value="Gr19_v10_g13500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13500.t1"/>
        </source>
    </evidence>
    <sequence length="563" mass="62369" checksum="A8255717293462D9" modified="2023-02-22" version="1">MAPQSSRRLHPSAPSLYSLNFLPHLVPSSLPFSLLLLLSRLLSFLPTALCASVGSTTAQCPDGHFLSRFSSAFDGNERFYKFSCAKFHGGWTAAMLEERCEATELTRMEDGGDAYLSCGSDQYTAGVRVVDGALSGDQRAEWWQLLCCQSDSVLVRVADCVETKFINDIRRSSSFSSGAQVIRRWQAMFDNGDRRWWLQICPVDVNLPLKKHKLRSDGAEVRARRAIPLEWRRSRFPTTSIQHFHHYTFADDGVTDFRRQTQISRAKVNSYAVPTLNGGRRQIGIKNGKSQAKVADHPTTTGNAPTYWSSASTTPTATATTQVAVAEKEEEDEQTVDVPNLMPSSDLPNLMPSSDLPNLMPSSDLPNLMPSSDLPNLMPSSDLPNLMTSSDLPNLMTSSDLPNLMTSSDLPNLMTSSDLPNLMTSSDLPNLMTSSDLPNLMTSSDLPNLMTSSDLPNLMTSIRPTPRQLEPFSDQQRRLSRLHQFNGRMRSRFESRMDTSTTASSTSTTTEVMTTNAKKKAIKKMAPMNGGEGTQREEPTDALDYYDMLALFGAFAKTKQKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H629</accession>
    <name>A0A914H629_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H629"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14161.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14161.t2"/>
        <property type="gene ID" value="Gr19_v10_g14161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14161.t2"/>
        </source>
    </evidence>
    <sequence length="191" mass="20288" checksum="373D456EBA3192BD" modified="2023-02-22" version="1">METAICIISIFGGVGDEPYFQSIAIVCLLCQGSISAPQFPCCPGSQKVVSLMNSHIGTFSASMSQTELCSSAEKLEGNLRIELGQTSAGCLNGGDKALMRSIDVKLPTSADECAHTADHAGNNNNNNSAWSTLVEQFNHQIDVIDKNCDELKMSIGKVNFSLGRESDAHQEVPGPDTVLANPGKFGSHNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H640</accession>
    <name>A0A914H640_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H640"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13575.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13575.t1"/>
        <property type="gene ID" value="Gr19_v10_g13575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13575.t1"/>
        </source>
    </evidence>
    <sequence length="885" mass="95998" checksum="2D66D360827E3B8F" modified="2023-02-22" version="1">MSGRTRTPPATAADSPSASRRRRPPLPPPPSRGVLPPQRLSSEQQFYYLRLMAKPGQRPEPIKVKFPRWPSVEGAGGPVPGTSGSAKGPAEVGDHRLEDQAIAVVRTIGQAFDLCNRMSQEQTRERQLIEEERTMDSAGAVAGGAAAAGGGTSTGAIAAAAKGGGAARASVASEKSTSSLATVQQRQQQQQQQQRLNSPPFASKRHSIYVPKRTTTTEEVEEAAAADEPQTGDGDDEEEEDEAEELELFRREVRDHHYQKAGPSHKSSIVFPPTNIPTVAPGGAAGEPHILRPALNIPATAGTSTATAAAQMQSSSAYGVQHQQPIATQLTMLPGAQTNPTPLAVPFSSVWNFTTPVQPNTAPLSAQLVQSVDANGNPLYSILPSPTAMSLSSPLLISPYATLQLPPSAAASLASPPSSAEQLQSPSSSENAQRAMIRSQLDQAQQSAQVAACQVQLLRDQLNTETTARLEAQSKTHQLLNSNRELLDQVQHLVSRLQVMENRVAAGLLNHLGDDVPPHQRQSSSKERRALWRTERRDDSLRPDEEEEHDDGTGPGTSAALSMRELRPYQLKTLSDLRAGSLPASEESRTKQDELEDGREHRRQQRRNNDRRRQRLRRRRTDSVDDLGSDDDDEEEEDSTDVNSSVDRAAPGAVDQPSSSFPALPALSHPQARPAPAPSILRKLIPASAPSPTGTLSGSPLGMPLLFGQQMVNRTMHNLSPARRKQIHHQMAYSGPPTLQRPPNDVVLPIGMSKKSLRRFSLQAAELEPEQHKAKKASSSKGVFGQTEFKRMSFNTNPNKKMHDDKSLINIRPTINESEGEESVYTAERRNSRSSPEKKLSSPERGGAGGRRRSSLGVLGKIVGTNKHLLSRLSLRNNDLETEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6E4</accession>
    <name>A0A914H6E4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6E4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14244.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14244.t1"/>
        <property type="gene ID" value="Gr19_v10_g14244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14244.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10373" checksum="6911E7E5EFA74DB7" modified="2023-02-22" version="1">MAKKKCLLRDTVRPPLLCCAYVCEMCGRHSDGAARPAICQGEGRAVGWAGPTLSAVGWASYGRLIVNRWTLVGERENGTFQRQTALKGMFEAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8N9</accession>
    <name>A0A914H8N9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CH-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8N9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1523.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1523.t1"/>
        <property type="gene ID" value="Gr19_v10_g1523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF9">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CH-like" evidence="3">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1523.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23592" checksum="63DBBA993069A6C5" modified="2023-02-22" version="1">MRPNTNTPSSSANTKSWEETIAWLDFSDGALVAEIVAHHLPRYVLSSNSFPQVHSLALKKYNWETLERTVLCHLGIRLSVEDIESLANAEEGAIQTFLAILRVKIDSAITQRRFRPSSTSRGSSRSCSRGGSQLHLDRIGGLQGQSNGGGGNGRPKVLDELDQGQLVEKLYAKVREQETQLRKKDEQIEALSRKVDKLLEMVCEECLKSTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H942</accession>
    <name>A0A914H942_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g1518.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1518.t2"/>
        <property type="gene ID" value="Gr19_v10_g1518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056872">
        <property type="entry name" value="TTC3/DZIP3-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022:SF1">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24525">
        <property type="entry name" value="TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="178"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1336"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1552"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1552"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1578"/>
            <end position="1590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1518.t2"/>
        </source>
    </evidence>
    <sequence length="1608" mass="177378" checksum="3334F9C95D2B9001" modified="2023-02-22" version="1">MIRINATCGNTKTPLMMTSHSGETSPGGSNSLSNASLRTRTTGEENQASPHKSFNLDCYNSSPERDDESDQCDEDALSQLMLHSELFRQRSSIGVQTDYNEEFPPLKFLRALGEDPTMMMGHPPFLFNAGGAVSEVPSSLQQTHQLSIPSLSATVPTTTASAAMSVNAADATSSTSSDGMLQLVIQNFRHMSDTVRGPCKYIQGVPWRIMVMPRQHVVQKKGTQKCLGFFLQCCPDAYSESWSCQASAELRLISQKPGVPNFTRKTNHVYTAKENDWGYSCFMTWADILDEAQGYIKEDKVTLEVSVKADPPRNILTHKEFQKKIQDYKRLADLQCHRGLIDKAIECNTQALKFCKDKDPQCKTELEAQKAHLIEMKLKQSIQRIEKGGDGGKIEDDSATNLNALRQALGTTTRSNNSKTTKNKSTSTKDKETVTTGNNNVSNNNGTGVDRQQQNQRAGTPPYTTQQKSTIDQQSDQPLLKPTKNSRPIEPQIQKTSLVSTSTTGTTANNSSASSTEMLCAADDFDFMKDRYIEEEVLLPNQIKHFLCHLSEGGKSPSRLKDQIAKLEMIASPFEKHDPFLEELMKIDPKEADNALVKALAFTSIERESDREKCLSKVIRNKICESCLKEGHFQIEKRETSESGCQTEFARRVPAEVHADDATFRMMQQIQQQQHLVGHGQPTAEDYMNVLNNQAAFAAAAAAQQQQNQMHASINVSTLPPARRKKAAAKKSVQQHQQTFTAQHQQNILQQQLPQFMPKVASGRLQTDASQAMNAIGGLDLSDPRMEIFAAAAKPFIGTPGIVENLSALADLDLSKLQFPTETNSTDPNQGANIFSRQYIEEWFRYSARNVLKLNYDHAGDNKAAGTAAANYSVIETQQQQLYAATASSGTTEQEMQFNEAAALGVIQLNCLNARTIQQKVAEFVETLESHPNFRDLRTSIERLLSLSADDENFTNPEDTVSVVSVSEISGRDVELNREPPSHDFSNIQRLFLEDDPHDYMLLKELKQTEMVLATRLNSIMYQMHQASIADIVDRIELKTKTLEDKLKASKSEHLKMTTNEKKSAEQLSQLHKDLQTLNGKYEKLIQQLKERKNEIKKLEKKAKSEAQLATENNELHEKMDTMKKELAQVQRQLSDEQAKYKRDTQSLADSKKHLSIELNGRYAEVQKLTTQLEEKAQTLKKSEQQLANERKNSSQTISNLQERVKRSEVNLLEHKLDDGLRVLERAKDDCSQQIKLLEEQRQKRKSSSSDLEVIKKNIGEWENKREEVTALIVQAKNDFTGHIQSIKNGKQLSQLPKIQPVPSSSLVNQPSNGAIQQPMPPSPLPLDRKVITPPGRSHISASAPQQHGHPGAALGQHPNITATAQTGRQSIPSSANVTPVKFQTQPPGHLASIAPIGVRPQNYQNGISVPLASSSSTTMQQQKMSGCQRHSPQLSGASMMGGTQFHATAPPPPIQQFHVVGHPLPPVGQPSVPLQQQQTNAGGSGVAGSGSFQTWGGGWGDQLNNISELFGQGRSFGPLGSEFGGSGGNVIDGMRSASVIHPPAAGVIGAPSSTASVGNNSNNAPSSQPIGAGRNLLNVSPSQQQQRNGWPSFVADSWNMPLSGRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H996</accession>
    <name>A0A914H996_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H996"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14959.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14959.t1"/>
        <property type="gene ID" value="Gr19_v10_g14959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14959.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8490" checksum="69289CB5303C95BC" modified="2023-02-22" version="1">MECAIQNSILELHSDWMLHGDKPTTSGGNLRTPPMEIYLEWIVSAWETLSKDITVKRMERFQMDYASADKKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAK1</accession>
    <name>A0A914HAK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15320.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15320.t1"/>
        <property type="gene ID" value="Gr19_v10_g15320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="206"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15320.t1"/>
        </source>
    </evidence>
    <sequence length="409" mass="47313" checksum="2EF79D09329B8878" modified="2023-02-22" version="1">MANKLILLPIEHYRGLIAAREKIDDDVTEQTNFGFVKQQFEKAKRKRAANVSEKSAEYNQQLRRYLKLRKEVKDKPVKVQLSNGMRLMTKPPATGVQLKPGPEEVEETIVIGGSEADDDETATISTPKFSTPKEVEVGPEPRPSRKRDLKKQEIMAKEQQLLSIIKSDPKRFGVNARDKIINPSTGREFIDFDLTRAIERLVNPRPENAPSPSDVQADLADFQALSRKNSGNRYLLLAIDVLSRRMFGAPVKSKKPADMKRAFVELFGQMPKLPETLYTDRGLEFVAKPLKEFYAEKGIKKFETSSKKKAAVAERAIRYMPNYSDHVYTVDERRSSNPEHYFLKDYYGTKLKRKFYLPELTKVKVDKNTLYRVEKKYKERMRDGQKEMLVKFIGFPEKYWVTNEDFVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBZ1</accession>
    <name>A0A914HBZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1570.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1570.t2"/>
        <property type="gene ID" value="Gr19_v10_g1570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1570.t2"/>
        </source>
    </evidence>
    <sequence length="1051" mass="121682" checksum="5CCC06B922C03236" modified="2023-02-22" version="1">MIVFGRCVLVDGWQRETGEVFAERTKDGKRSGGQKSGSLKRTSRRVTSQKVTSMAPRPFILPLLCLLSSAFFEAILAESIVFNIFSTRTNDQLLFVHNVKDVGANWTILPFEGEEQHIFDEMRRHIQTDDRPKAFVQIDGQTITQRLYQEPFCWLRGICWRRNRTAETFVFCNGRLAEILRLLRMNGCESAEEKGGEEAERTDEFNEVGWSTTFLAVEATPNGQSGKKGGKGTNSKNKLNTDGKMMSEGDQRRMCRYRITCYEKMGFSHLIGKQQKQLGGKVLSGKMAPPEGSKRTMKQMAKVAIKGVEKSEAEGKTKKELDERDGETVLANYRSGRERKLRCKYRKSCYRSGLRPTIESNLLALWLNRSGTKGYGEEEGNKSEEAGREAEWDTLDTKQRKVFCRYRKSCYSNGSRTMGKSEWRWDDFEIDFGFTQKTSEYWSNLRKMVKGRKGVAKKTGDETEMGGPKEEEAEEDTGEEAQRRKLSCKYRRSCYKTGELPEALRTPEGRTEEGGAEGAAMGRKRVPTSVRELKVFCKYRKSCYLASATGTETAEAMRAESSQNKTSGQSEKEEEWVEKIGEEVQKLTERQKTKRSAVANNDQTDGRREEGEEKREEEEHGAEVSKKRSNKKKKRTEVSEAPKNGEDEVKRKEDEMKREEEKQLNRNEREQEEENRKEKKEKPKRGGQRKPKTSCSPEKWVKEKKVDPGGCREKRDKEGVEGEKEKKAEETQKTKKKTKRKEEVKLEEETNKETEATEIGGEKEKTEGLNAEKEEKEIKERKKQQYKPKKRTYKVQVAEVQGQKSKVWSRNWLGLSSAERLECRYRKSCYATGTRPTSQRWTIGGDEKWWRCWEWHNLWRAVPWIFEEQQKKEKAHKSNKIEGWEGLSDRARKQKCQYRKSCYDRMEPWEGSGTEGDGPNGRTDSARKKEKPRPRKAADFTPKTVSREADKRKREETLRREVIFKSVDMATKLHCKYRKSCYEGSADRIMAPPPIILRINATNGEFRAGRRWDCPSGRRRRLDRTEGNCAEEGKWPTRREGKTDGRKKQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCA3</accession>
    <name>A0A914HCA3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription factor IIH subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">General transcription factor IIH polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCA3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15781.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15781.t2"/>
        <property type="gene ID" value="Gr19_v10_g15781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15781.t2"/>
        </source>
    </evidence>
    <sequence length="502" mass="56833" checksum="0104B737916062FF" modified="2023-02-22" version="1">MCITPTTLHFLKDLKNLFERQTGRANWPQPLFSTFVITVLMNPLVVVYYVILCVYYVIICAYFYVYILCAYVYLTLCADVRFNFVCPLHTPSQKKYGHGNKSTKDKKGQIGVKGKKKITLKFMIGCKNPVEDGIMKTATFETFLNERIKMNGKTNQLAANGVKVEATKTKLVVTSEQPFFKLYLKYLTKKFLKRNSLQDWLRVVASAKDTYELRYFQINQEEEAESDNEEMTNGGNISFLCVIIDCNAYNWGNVVAEHGVSVLNEAIAALIALCNAHIFSSLGNRLLLLAEGVGRRDKKLFTNERMDTNDLTNFGPTMEGIIHQILAKNAVSTEPNPYNLSNSLSLSICAFQRFKKRFAASFGHIVFINLSREFSSEQNSLLNLFFASRQYSLHFHVASFHKTVPILQQASDITGGSYIHVINTKLLAHELLCHCVCGHQNGPSPFGRLALRDIDYRAKCHCHDQLLDIGWVCSVCLAITCNCVPFCKICNAVKEATMNEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDI6</accession>
    <name>A0A914HDI6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDI6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16126.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16126.t1"/>
        <property type="gene ID" value="Gr19_v10_g16126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16126.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19943" checksum="12FD0CE141AB3F15" modified="2023-02-22" version="1">MGNILYAPENLGLHSKIKCDNCGTYEVQHKQLTLRKLPIVACFHLKRFEHMNATMKRQKIKYPVRYPEFIDLTPYTTSHRNALSPGDQQQQLREGTSGRQLTSLTNRYSLFAVVNHNGSTESGHYSCYIRHQHDNWYNCNDQKITRERIDKVLASEGYLLFYCKSYIDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDS8</accession>
    <name>A0A914HDS8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Probable histone-binding protein lin-53</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">U6 snRNA-associated Sm-like protein LSm8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Probable component of a NuRD-like complex, composed of at least lin-53 and hda-1. Interacts with lin-35. Interacts with hda-1; the interaction is direct. Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1. Interacts with hcp-3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDS8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g157.t1">
        <property type="protein sequence ID" value="Gr19_v10_g157.t1"/>
        <property type="gene ID" value="Gr19_v10_g157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000021">
        <property type="entry name" value="histone-binding protein RBBP4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000022">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="17" id="KW-0137">Centromere</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 24" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="24">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="24">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="24">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="24">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="24">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="25">
        <location>
            <begin position="429"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00063516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00067443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g157.t1"/>
        </source>
    </evidence>
    <sequence length="526" mass="58799" checksum="FA4118C302FC8016" modified="2023-02-22" version="1">MSSLSASQTQPSEDSEERLINEEYKIWKKNCPFLYDMVMTHALEWPSLTVQWLPDVQRQEGADYTIHRLILGTHTSDEQNHLVIAKLLLPNDDAQFDASRYDTDRGEFGGFGTVTGKIEVEIKMNHEGEVNRARYMPQNPVLIGTKSPSSEVYVFDYTKHPSTPADVDCKPQLRLRGHTKEGYGLSWNNNLPGHLLSASDDMTVCLWDIQAATANANFLDAKSIFTAHTAVVEDVAWHVLHDAIFGSVGDDHKLMVWDTRTNSATKPVHVVEAHSAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHIWDLSKIGDEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMADNIYNEEELDPALVESVAASGAKPMELEPFVNKCVSIITGDGRNIVGLMKGFDQTVNVVLEDSHERVYSLDSGVAQIPLGLYIVRGDNVAVIGEVDETIDKQLDLDKMKAPPLPAIWIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEF4</accession>
    <name>A0A914HEF4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 93</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16381.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16381.t1"/>
        <property type="gene ID" value="Gr19_v10_g16381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16381.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17252" checksum="041CD0B4D0A72106" modified="2023-02-22" version="1">MKSERKSGGVSSSLKKQQQHNLASTLPSSTEITAPTRSSLPLAVKNVSNKGQQPPQKHIYSDSALRNNYQVLEQSRTCQAAVSGMASGILGLTGTLGFLLYFICVLLQAFVWHYKAGFRWSAFFTSRSLLLTHSVVGGLFTYVLFWVFVYGLVHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEN6</accession>
    <name>A0A914HEN6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEN6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15923.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15923.t1"/>
        <property type="gene ID" value="Gr19_v10_g15923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15923.t1"/>
        </source>
    </evidence>
    <sequence length="651" mass="74014" checksum="6CE47D135A2DB0D5" modified="2023-02-22" version="1">MQLARRGPKTYWPDVAPRRSWPRDAVGQTWPQDVVGPETQLARHVVGPETQLAPRRSWPDVAPRRSWPRDAVGQTWPRDVVGPETQLAPRRSWPDVAPRRSLPRDAVGPETHWPRDAVGQTWPLDVVGPETQLARRGPETQLARRGPETQLARRSWPRDAVGPEKQLALRRSWPDVAPRRSWPRDAVGPETQLARRGPWTSWPRDAVGQTWPLDVVGPETQLARHELAPRRSWPDVAPRRVGPETQLARRSWPRDAVGPETYWPRDAVGQTWPLDVVGPETQLARRGPETQLARRGPETQLARRSWPRDAVGPEKQLALRRSWPDVVGPETQLARRGFETQLARRGPEMQLGRRGPETQRSWPRDAVGQTWPLDVVGPETQLARRGPETQLARRGPETQLARRSWPRDAVGPEKQLALRRSWPDVVGPETQLARRGFETQLARRGPETQLARRSRPRDAVGQTWLRDAVGQTWPRDAVGQTWPRDAVGQTYWPRDAVGQTWPLDELAPRRSWPDVAPRRSWPDVVGPETQLARRSWPRDAVGPEKQLALRRSWPDVVGPETQLARRGFETQLARRGPETQLARRSRPRDAVGQTWLRDAVGQTWPRDAVGQTWPLDVLAPDVVGHETQLARRGPETQLARRSRPRDAVGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH04</accession>
    <name>A0A914HH04_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SAC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HH04"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17282.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17282.t1"/>
        <property type="gene ID" value="Gr19_v10_g17282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="4">
        <location>
            <begin position="119"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17282.t1"/>
        </source>
    </evidence>
    <sequence length="540" mass="61628" checksum="7B0A41AA92C289F1" modified="2023-02-22" version="1">MADREFIAGEPDHDYSQADIGELLATVSSSSIVTPTEKWNKRRSCTGGGGLLRTVEKAWGLIGAIRFMEGFYLLVVSRAKLVVSIGFHSIYKVEDVSMIYIPATGTASHPDEAKYSKLFLSVDFTADFYFSYTYQLSRTLQENCLAESDIKWNRKHFGRTMGPEEKFVWNEYLMEPLHRNGVSRKWTLELVRGFVAHQLLELPCAKLELILLARRSSAFAGTRFLKRGVNCDGAVANDVETEQIVWDMDSPLSFRYGKFSSFVQRRGSVPLFWSQDPTHRGSPMVVGKPPIVIDRVEPHALTTAKHFRELERKYGHPLVVLNLTVCYLNDFRKVGKRIDYVSFDVSRCNKSGRVLQRLEEIGQRLTLSTGWFQSFPQLHSRLPSNLLRQRSSTTPPNIDENIGRFVAEPSMDGRMLLQHGIVRSNCVDCLDRTNVVQFGIGKVALGWQLYSMGFLSSPWALSLHSEVCRVFEEMFDEHGDILAWQYAGSQLVHSIKTYKRTAIFQERSRDVLQTISRYYSNTFGDFEKQDGLNLFLGVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHC8</accession>
    <name>A0A914HHC8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHC8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17178.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17178.t2"/>
        <property type="gene ID" value="Gr19_v10_g17178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15522">
        <property type="entry name" value="PHD_TAF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="546"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17178.t2"/>
        </source>
    </evidence>
    <sequence length="640" mass="70737" checksum="BA90277E2A01678C" modified="2023-02-22" version="1">MNVGAARETNENERKSAGYELSRFRHATMAIADNIGFASASSSALSSLSFLLRTYFEQLCRDSLDSAINARRSEVSLEDVSHVFGVNGINLTELHGYIHQVASFAFAEEHPLFPVIEPMSLLSTEIANSEEQKQDERENAGNDGTEVDEEGGREQNNKQVVNSSSSRSNARNAIFQKIFPNFAGAFAPSLGFTVQRVELPVENISVDQQLVNIRPSSSKTAVHTMFEFDHSIAQPLRTKAAISEEEERLLKKKRKKEKREKEKRMAEETEEKTGNDGKRKKHKTKDNSADRGADEESSLLQPPSIPDKQQQPMPISPPQEPLKIPKLKIRIPITQRLSPVGHPPIASIAQENLLISRHTTEPMKQERLNRSDKNTKRSDKNTKSDDKNGNRNDDNSCLENSRRTKPSDNCNSTNDNVNWSNNNNNDRINSIGGQATAHSVAQAPEPKSENGRSVKPSKRKFEESETEKPMDKGPAKPKTASKALKISSTPKLPKTPIFPARANNSAAKVKAIAKAVEQIAAAQLCSASLETVDNAGGANEEEEEPIWICPTCSVAYVEGQEMVACDDCDRWYHWGCVGILIPPPERAQWYCTECRRKRKKSQQQLLTDGGGGSGSNSRKTSLTGAAPLAVTAKKQRVTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHM6</accession>
    <name>A0A914HHM6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHM6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17592.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17592.t1"/>
        <property type="gene ID" value="Gr19_v10_g17592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036903679" evidence="8">
        <location>
            <begin position="27"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="63"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="370"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17592.t1"/>
        </source>
    </evidence>
    <sequence length="613" mass="67588" checksum="E2038D64070C9079" modified="2023-02-22" version="1">MPMFHTIPSSSSRFFGTISVLALAVAANFSSPIAVSEERIQDLTLRDLREIARLAYPHKRRIFAGLCCLCVSSAIFLSLPRLLGKLIDEKKDKTPSDSSLTSRIAHFFKDNIVALLALVVVGAVTIGARAYLMHTAGQLIVNDLRTKVFNSVLRQDMAFFDRNKVGEIVSRLSSDAFLVGNSVSSNLSEGVRALFTCLGSVGLMIYTSPDLSIMGSVVIPFVVVSIYKFGKLQRLYTLQMQEAVSNTNQLATERLSNVRTVRIFSAEGKELQTYKNKILEIWSISKKEGMTKGLMFGGVLIAEGTLSYGDLSAFMIYSVLCSSGISNLQQFYTELMRGLGASARLFELRDEKPTIPIEGGLVISDLQKEIRFESIAFAYPSRESIFNGITFRIPKASVTAIVGPSGSGKSTIAHLLLRLYSPTAGRIMIDDIDLRQLDLTAWRKMIGTVSQEPILFSTSIRDNILYGVENSHLITDEELSEVAEQANCFDFIQSFPNGFDTLLGEHGSSMLSGGQRQRIAIARALIKVTTSALDATSEFLVRKALDALLVKSGQTVLIIAHRLSTIKHADQIVVLDKGTVAELGTFDQLMSIKDGIFFRLVEKQTFDWKCDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHV2</accession>
    <name>A0A914HHV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHV2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17078.t3">
        <property type="protein sequence ID" value="Gr19_v10_g17078.t3"/>
        <property type="gene ID" value="Gr19_v10_g17078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000265">
        <property type="entry name" value="TWiK family of potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF337">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="137"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="615"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="760"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17078.t3"/>
        </source>
    </evidence>
    <sequence length="818" mass="90502" checksum="866F5C3AF7F1E60F" modified="2023-02-22" version="1">MPSGFLPFRKCPGGIGNTQIGRNLDKTHKIGQNGTGGHPIVLSSHIVSNEKACRFHHFSCRPLLFGGRLRRFGRLYGHIANDTWTVVQKLYEFIEKSEVIREDEVKREAHRLYKQYEQALVFAVNYEGYDEKYDDSHPTFQWTFSGALLYSITVFTTIGYGHICPKTALARGLTIVYATFGIPLMLLCLANIAESLAQVFTFIYFKVCCAYCRWQAKKRHEKRSALKLRYHPNAPVNVRRVHSGRAAQRYNSLLRRHASLSMRGRWGTGDTKTWSAHFGQFIRASRSTGDEQRRKVPHRRGQRQRCSFSTAENALVYVVVVFLRAQTSPEGRKRGSTVAGQMLPATTPNAPICGGVPVRYMSGYGGPEDDRSALIELKPSTSLQLCDFVASPNDSLKLKERRKKLSAPPTSAAHLRAVGSPRPFEKLQSPRSKVSCAENNNAVPDILLLETASARVHAELPRIRVNAGADESRSVDGTETTTERRESGGTNRRGRGSVGLALSDGESAENEDGGEDELADKFGSQPQLCQYHPAMARRIRHGLLEPISPASCPVNAGTALEQLQQQLMTKEPSDGSVGRRLEIRSYPSDSESIRSVRRAGGVRREKMPVSVGIITVILFIAGGAMLFSIWEDWNFFDGAYYSFITLSTIGFGDIVPGQSLDEGSQEKLIVCALYLLFGMALIAMCFKLMQDDVVQKARWLGQRIGIIVHEDIDSEGSDFDEEAIALEGEEEFGGIFGGADDGEELLGDDDDLLSVKTDQEKHTISSGSSTNNKALQVQEELLAASREHARRGRVAGGRTSGRHARAVRGKRTRTEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIH0</accession>
    <name>A0A914HIH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16933.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16933.t1"/>
        <property type="gene ID" value="Gr19_v10_g16933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16933.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39957" checksum="AFC5EF088C6BA846" modified="2023-02-22" version="1">MSDNVSDKEQQQQMQEISICGDVWLEIFAFVSPLQLGHLMALISDRFDVMVDEHFKLKKWSLSWLQIRRAIGGNGAQIVKNFAEWLPIPQGPLPTKVIGFKEIEISYVDQNVIEFLQRIRRLFDSAGTIVAIYTSDKQSRSWDIIWQKIWPFVGDNICGFSLDASQLDRLRQFSPTVLRNCTNLRSIDSAKLFPEFPAEDNAIASSRQAVAKWLITPRGDGVPKMLCCCVYSGGMDGIKGAFVNASEPVNFIVSFENVEWVDDFVQFELENNLTAERLTLRQMDEYVWLLVRCPIAREEDKWTNWEKEAIDLDWWDYQWNCISIDFKDWDIGDGMVKAKAGRMCLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIH5</accession>
    <name>A0A914HIH5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIH5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17477.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17477.t2"/>
        <property type="gene ID" value="Gr19_v10_g17477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="8">
        <location>
            <begin position="553"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17477.t2"/>
        </source>
    </evidence>
    <sequence length="905" mass="101491" checksum="00FD986D8B938127" modified="2023-02-22" version="1">MSLFCDLPVIFKWANSNRRITAQFRSYRLGKNIFGCGKRPIGARLGAEGEKALMRRGVEKKSVSALINAFRRFGYLQADLDPLGLSEPFRVSELDYDLYGWDNGDLEVPVGEGATATLGELIGHLRDTYCGKVAAEFMHLTSFEERQFVANAFEHSGKGGDFTSNERLEAAEVMLKMKAWEKFVSLKFPTLKRYSGEGADSVGAFYRQLLEECPRHGISEFIFDGAHRGRLALQTVLFNFPRGQLFRKMRGLAEFPDHVKGIGDVLTHQHSHFDYTSVDGKTVHVSTLPNPSHLEVSLAVCTGKARARAQTLRVGDYGDGIVGDQVLPVHHHGDGAFTGQGVVWEVLAMSQALPRGRAIGRSSLHCTDVAKAIDSPVIHVNAESVENVLFAARVALAFRQKFRKDVFVNLICWRRYGHNELDDPRFTQPTMYRAVDSKRCLVDAYVDGLVEEGLSSADQFESIVSEYSETMRKELELVDSGKTPPVAEHLDGFWKGFRQAPSAITKWDTGTDIELLKFVGLASVAVPDGFNVHPHLQKMHIDARRRRIESGEIDWSTAEALAIGATLLQGNDVRLSGQDVGRATFSHRHAMLVDQQTDEVRIPLNHITAEQNSFLEIANSPLTEAAVVGFEYGFAIENPARLVLWEAQFGDFYNGAQVQIDTLIANGESKWLLQNGLVLLLPHGIDGAGPDHSSAHIERFLQLTNSRESQEPFEGDDVNMFVANPSTSAQYFHLLRRQVVTPFRKPLVIVAPKLLLRHSFTVCALHEFGPGTFFKPILLDHKLSSDRKEVEKIVFCSGKHSVILMEERDRRRLTNVAIIRMELLCPFPAEEIAAVFEHYWNAKEFIWSQEEPRNAGCWTFVESRFRNAFGILLKYAGRPELDWFASSIGDIHKNELEHLLHSTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIJ7</accession>
    <name>A0A914HIJ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Importin subunit alpha</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIJ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1786.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1786.t1"/>
        <property type="gene ID" value="Gr19_v10_g1786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="276"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="318"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1786.t1"/>
        </source>
    </evidence>
    <sequence length="419" mass="44357" checksum="72F3F8ADA1FA6194" modified="2023-02-22" version="1">MLLAAPSSQTTTDDLMNSEPDSNADKTTIQLVIQAKSSDPKKRLRAVSRIRGLLSKSSNPDELPIAEFVSIGAVPVLVNCLKSTDGKLLVQAARALKSIACRKALAVVEAGAVPLLVKLLKSPNLEVCKCTVDVLANISWRSNARENKIVEAGAVPLLVKLLQSPDMELCEYTAWALKNIAADKAREVVEAGAVPPLVKLLQSPNMELCKEIALALTNITAASDDLSRAVAEAGAVPPLVKLLQSENMELCQHIGWALTNITAASNDLARAVIEAGALPPLVKLLQSENMELCQHIGWVLTNITAASNDLARAVAEAGAVPPLVKLLQSPDMDLCESTAWTLKNIAAASDDLALAVIEAGALPPLVKLLQSENTNVCEEASLAIGKIIEKIPDLNGCCIDAGHIQIMASGTSNKKNIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIZ2</accession>
    <name>A0A914HIZ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIZ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1890.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1890.t1"/>
        <property type="gene ID" value="Gr19_v10_g1890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038024195" evidence="1">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1890.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23451" checksum="3CF13BE49B7D20A9" modified="2023-02-22" version="1">MKLFAMLMLRYAFVMLSSSLLRNGTKATLDELENWKKSCQELAVSIAQQEPIFLHHPKYINKMIMEPLTDLLDKVKKFPIEGMEEPLSRRLIKPLGIAIGNCEKILNEVEHSGQEDNKNYEKGLLSKINSIAKRIDKDFNLFIMEVELKLIEKVNWTSGNNIELTLLERLEELAERALKEAIPLKDIITKKLDELRMDKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJQ5</accession>
    <name>A0A914HJQ5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Zinc finger protein-like 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ZFPL1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HJQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17518.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17518.t1"/>
        <property type="gene ID" value="Gr19_v10_g17518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16487">
        <property type="entry name" value="mRING-H2-C3DHC3_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058730">
        <property type="entry name" value="U-box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039043">
        <property type="entry name" value="ZFPL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058731">
        <property type="entry name" value="Znf-B_box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25998">
        <property type="entry name" value="U-box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25993">
        <property type="entry name" value="zf-B_box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17518.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32676" checksum="5E5923B4D06FC6CD" modified="2023-02-22" version="1">MGLCKCPKRKVTNLFCFEHRVNVCESCLLSNHDSCVVQTYLSWLTDSDYDANCLLCFESLNSKETLRLKCLHLFHWDCFDSRARQLPQTTAPAGYKCPSCLECIFPSENQSSPVVDKLRTKLQTVNWGRFGLGLSSIPELEQNALATKAVETNSSANNRSDGIHHHKTPVVANSPKTSNQIAAHDDPFEVNTFTARAKFTDSGGNVSSRVNIGNEDDSKYVKAAAAERNIRNRFSRLPRSLKRVLMALIVVTFLYIIFGLFISGHDSSQGQNAGEDTLFDPLANPNIKVRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKC7</accession>
    <name>A0A914HKC7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKC7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2125.t3">
        <property type="protein sequence ID" value="Gr19_v10_g2125.t3"/>
        <property type="gene ID" value="Gr19_v10_g2125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2125.t3"/>
        </source>
    </evidence>
    <sequence length="169" mass="17929" checksum="AA6D977A9C0CEAF2" modified="2023-02-22" version="1">MSGSQMSGPQMSGPQMSGRKCPFCLRPQVSGPQMSGRKCLSRKYSGKISSIEISIENLDRSVLYKGVATKSGISDTRVSCDENCTIIELPAHFPSSGRVVDTLAACDCFIAGIVPFLNAGNGLLKALKKATFLAGESVGQRGLLVKVVAFISSSWAVLAVACRKRWVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKU4</accession>
    <name>A0A914HKU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1755.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1755.t1"/>
        <property type="gene ID" value="Gr19_v10_g1755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1755.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15401" checksum="73567022DD7AA916" modified="2023-02-22" version="1">MLISQFALINVGTQKMEAAKCQKELDATELMELADSATVETTAGRRRRRKRMRSLNVEQQPQQTQAGNNNNGQQRWKCRLVLAFAVLTIVTLLYAITLFARHRTANNESFMLINLIAFVLSEGTYIFCCSNLINSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKW0</accession>
    <name>A0A914HKW0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKW0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17807.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17807.t1"/>
        <property type="gene ID" value="Gr19_v10_g17807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037150143" evidence="2">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17807.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13266" checksum="EED1CA56074290F3" modified="2023-02-22" version="1">MQSGHSMLCRRCAILALFFLALCACPEAQRTPPAEAEAAEEENGGDANGAASYDAPALTVEREEALPKPPPPAHSDDDAPATVTHAHAHETTTTTPHSSGSSPSSSLQVLLILLALLSSMLTISRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL28</accession>
    <name>A0A914HL28_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL28"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1788.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1788.t1"/>
        <property type="gene ID" value="Gr19_v10_g1788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF910">
        <property type="entry name" value="COLLECTIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037271722" evidence="3">
        <location>
            <begin position="24"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1788.t1"/>
        </source>
    </evidence>
    <sequence length="664" mass="69899" checksum="C343C2C605FC9887" modified="2023-02-22" version="1">MIKLRLSILFLILSGFEVGQITAHLGHNSQPAVHQQPPQIQPSSSAFLHQMATNIHTMNKTVLEEDGNKKKETQTPNAENEKTQNKKSNKKGVVRRRAGSKNTVKHGKKLRSRIGTFLFYVCMVVSNWDQDVDLVAKNPLTGYSNIAYGLHFYAGTHGEALKKRWPSHVCDRLEHLGPTGPPGQPGGNGNPGPPGPNSESGPPGPPGDEGPAGKPGQPGNAGENGKSGDSGKREPKRVNCVSVQKGQTASRGQLRLGQLRLGANCVWPNCVSVRANCVWANCVSGPTASQFKKGQLRLGANCVSVQKGPTASRGQLRLSSKRANCVSGPTASGPTASRGQLRLSSKRANCVSGPTASQFKKGQLRLGANCVSVQKGPTASRGQLRLGQLRLGANCVSVQKGPTASRGQLRLSSKRANCVSGPTASQFKKGQLRLGANCVWANCVSGPTASQFKKGQLRLGANCVSVQKGPTASRGQLRLGQLRLSSKRANCVSGPTASQFKKGQLRLGANCVSVQKGPTASRGQLRLSSKRANCVSGPTASGPTASGPTASRGQLRLSSKRANCVSGPTASQFKKGQLRLGANCVSVQKGPTASRGQLRLGQLRLGANCVSVQKGPTASRGQLRLGQLRLSSKRANCVSGPTASQFKKGQLRLANCVSVIPKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLM3</accession>
    <name>A0A914HLM3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2482.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2482.t1"/>
        <property type="gene ID" value="Gr19_v10_g2482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2482.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10554" checksum="FA71C54EBA36A73E" modified="2023-02-22" version="1">MTKGTSSFGKRHNKTHTLCRRCGRSSYHIQKHTCSSCGYPAKRKRTYQWSIKSIRRRTTGTGRMRHLKLAHRRFRNAFREGTAATKKGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLS0</accession>
    <name>A0A914HLS0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1951.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1951.t1"/>
        <property type="gene ID" value="Gr19_v10_g1951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF210">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="147"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1951.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27658" checksum="0E999FA212CC2142" modified="2023-02-22" version="1">MFEIGEVSADEQNEHKHLIEPTELQLLERLCNGQFKMEPKEEAKIYCYYKRDKPFLMLAPHKVEIVRLQPLLLIFRAVISHTEISVIKKLATPKLRQAEVVDSDAGKVVESVSYRSSKSAWLNDAEHPLVSRLNRRVHEMTNLDIKSAEDLQVASYGPGGHYAPHYDFFTRNEVNPIADNDLFGNRVATVLFYLTQPHAGGRTIFTDLHVGVAPSEHDALFWYNLHEDGSVDLRTRHVGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM21</accession>
    <name>A0A914HM21_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2031.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2031.t1"/>
        <property type="gene ID" value="Gr19_v10_g2031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.20">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036745498" evidence="2">
        <location>
            <begin position="26"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2031.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32696" checksum="715BA3BD12E85864" modified="2023-02-22" version="1">MKAQMLALLFITFINYLGNYYSVCASPSPYQWNLTNSADNVQIFAQLINGIYQQSQPISKLSFNITFVKYASELANFRVIEHNNKETRPIFNANSDNGFVGFQRYSNKLDNFIANEFNRNIFCLQKPIPKTVVDQIMQLIFSYAARILLCVNIDKYYSYDGIGEWQMQTLLSAYKILAARNGNNENGIFPFPIEQIGGKGDHMWAKFMNQNISKQTSERKQFIDNTGESTVGESTIGESTIGESTIGESTIGESTIGESTIGESTIGESSIGESSIGESSIGESSIGESANAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPV0</accession>
    <name>A0A914HPV0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2603.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2603.t1"/>
        <property type="gene ID" value="Gr19_v10_g2603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2603.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25982" checksum="01FAD5585A9D3F10" modified="2023-02-22" version="1">MRVGGMRVAWMRVAGTRVAGTRVAGTRVAGTRVAGTRVAWTRVAGTRVAGTQVAWTRVAGTRVAGTRVAGTRVAGTRVAGTRVAGTRVAGTRVSGMRVAGMRVAGMRVAGMRVAWMRVAWMRVAWMRVAWMRVAGTRVAGTRVSGMRVAGMRVAWMRVAWMRVAGMRVAWMRVAGTRVAGTRVAGTRVAGTRGPGREWPGREWPGRKWPGREWPGRKWPGREWPGREWPGREWPGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQA3</accession>
    <name>A0A914HQA3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g29.t1">
        <property type="protein sequence ID" value="Gr19_v10_g29.t1"/>
        <property type="gene ID" value="Gr19_v10_g29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF21">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="552"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="1307"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="1351"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="727"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="827"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="552"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1351"/>
            <end position="1385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g29.t1"/>
        </source>
    </evidence>
    <sequence length="1404" mass="153544" checksum="5B6593A2F609893B" modified="2023-02-22" version="1">MMPSLEGPTPIQKSAAPLPSSKTKNIDEVPSLLGAAAPPEVPSSKADFDAAEKQRNKKQTTVVDPCATAPTPSQRFVCQTLFKWDKEIRAAPPPPPPPPPAAPGSETRDECMDLGCLCRFIGGKGQYSSNICQLANGQPLRKALRKEYRMLTDDERARYHAALKAIKQSGEYDEIAKIHASPAIVDGGAHAGPAFLPWHREYVKRMENALRQVDPTIAIPYWDSSLEAQLPTPADSHLFTKEFMGTTDEQGNLTYGHFANWKTIEGTNIRRRVGKDGKCFNETEINWFLSQVQIDQILAPSAPKDGQTHGGVHTFVGGLLKLPNDTDVADGDMAEQTRAANDPIFFMHHSFVDFLWEMWRQSKQTRENRQTEYPMDNAPLQNRGGLSNKYTDNMYEYAPRPTCQMGPNCGSKLLFCDRSHGQPHCAAKVRPGGNCTGFINGEDVCLNGICQNGQCQRNTPTAMPSLPATTAKPIKPVQTPTPMPPSPATTAKPIRPVQTPTPKPSSPAKTAKPIKPVQSPTAMPSSPATTAKPIPVQTFMAPPASKCPSPSCYNENICCQLWGLAGECNRNPTWMNCFCCVSCGRCIPHYDFGSCTDYNQGCKYWAKAGECGRNEWMLENCRRSCGTCVGFLELKQLCRMGGNGRGKRAADGMPSIDFANMDMSSLISRFVREVNRNRTNDEGDGFDPPLRGIPVVGGGASDAKDEACKKAPTKALRLYCKLNPDEGSTPIQQIAMPPPSSKTKNSDEGPPPLVGAAAPPQVPSSKADFDADAVQPPAGPAPPQKGTVSSNVDPCAAAPSKSQHFVCQNLFKLDKNAREQAARPQLLGAAPSPEMPSIAEVPSPDVGGESEESPIVMSAAPIAATPYECMDLGCLCEYVGGKGQEGSNICQLANGQPLRKALRKEYRMLTDDERARYHAALKAVKKSGEYDKFAKIHSDPITVNGAHSGPAFLPWHREYLKRMEIALRQVDPTIAIPYWDSSLEAQLPTPADSHLFTKEFMGSTDEQGNLVYGHFANWTTNEGANIRRRVGTDEKEKGFTEDEINWFLSQVQIDQILAFSAPEPGITHGGVHTFVGGLLPLPNGTDVADGDMADSPRAANDPIFYMLHSFVDFLWEMWRQSKQTRENRQTEYPMDNAQCASPQHFGSAPMRPFEHWENRDGLSNNYTDNMYEYAPRPNCRMGPNCGSKLLFCDRSHGQPPHCAAKTPTAMPSSPATTAKPIKPVQTPTPMPPSAATTAKPIKPVQAPTLMPLTPATTAKPIKPVQTPNAMRPLIATTAKPIKPVQTPTAMPSSPATTAKPIRPVQSCYNEHECCSVWAQKGECQQNPGYMSAWCKASCQKCQPDYDLYQECNNRHPNCQTWTSQGQCQRNQFWMAENCRQSCGKCRVSRQQVCSGGQGSQQNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR15</accession>
    <name>A0A914HR15_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR15"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3113.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3113.t1"/>
        <property type="gene ID" value="Gr19_v10_g3113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3113.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="31680" checksum="0C3FB918551561C2" modified="2023-02-22" version="1">MVTMAQAMDKPREKAGHLSSDEELFDFEMQQWEHELGDLTTGPRENREGVETANPQGQGERANASGQGLGVEAVLPVQQRVSGPQRISDPNGNNAGDLGVAVRPVGTPANGAAVQFQINASSWAEVQKCMPTPTLLIPASQGLRNAVFIPLDQRPSTSTGCRRETNSSGMGIESDRHAMENEPGNGTDAHGIREQDQTERKPRTASEPAQPAQIHQKEKSRGMCSRAQPDWNSPRLPLLTDTRRHPSTILTPTESRTGAHLRPGTTHRALEPRPFTRLPQPGDVLLVATGPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR88</accession>
    <name>A0A914HR88_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR88"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3904.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3904.t1"/>
        <property type="gene ID" value="Gr19_v10_g3904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037977775" evidence="1">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3904.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21982" checksum="872ECDFB095597DD" modified="2023-02-22" version="1">MEEFWILILVTFFATNSLDKAESVKVKLEETQLKTFDEIFGEEWWDKGEAEDLKTPAPTNFGQNVHHQIDRQNTQIGQIEPNLTDQLGQIEPNSTDQNAPLTDFKTIYSWKPWPKQPNNIYAHSKQKELMKHYYEIKDQNPKISDEKIAKMLKIVSRTLCRWKRQFKRQQFHPNSVDGQSLWRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRN3</accession>
    <name>A0A914HRN3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g3828.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3828.t1"/>
        <property type="gene ID" value="Gr19_v10_g3828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8206" evidence="2">
        <location>
            <begin position="1346"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3828.t1"/>
        </source>
    </evidence>
    <sequence length="1473" mass="166444" checksum="2ECA0688ACC1897A" modified="2023-02-22" version="1">MKRVTSAEWSYLFFVYKSQKRLRGHHHQQQHQKISHIKVYLWPSFARPIDEVADELAERARRQRADSTCPTESGFDLMSTAGGQNDEDDGTEVGNEHVAAILQHDQLSQHQQQRPTTNGQPTVKKKCFAVVQIERKDKSTIRLKYEFFVTEAEPFSASAAGDEHCNPMVGHMTQAILSNHLAMTFEQLTANFDLQLQHLDNYFEPAEFIDIELRKWYAERVQDRGKYKVLLHLKLDNNSASRIVDAEKVVPENVGGARRCDGEDVPMRGKPNTNKESAHRWGDEEVPIRGQQKPSKGNERRLDDEAVSIRGQQKPSKGNERRLDDEDVPIRGQRKESERRLDDENVPMRGQQNAKREGERRLNDEAVPIRGQQKPSKGNERRLDDEAVPIRGQQKPSKGNERRLDDEAVPIRGQQKPSKGNERRLDDEAVPIREQQNADDDWEPIDRFLVSGKYHLGNLYNVLSDNFVTSNDLGFMRKVFNMRSYTEQSLPTQGKEIIEIDHLDRLEERTKMLGTEQKLSVISRLARIDNVCPLGQFLLAASQIEGQCNSFGVIQILPETTISLKLDVPKVRNAVLLQQNPQKDATHFVGSTCFGSLVAAIVTFDQQTSDLVLKRIRGYPMTSSDNASLISLNNSVRISVFVDSSAGSGGTDLEFLHGLDVFVESTKKTAVGFNHKFGHPISFSLTPLSAIADDKSLHTFLPASLIEDYGLVERIQSCAQSVEQFDFRQCDELRQMFQQCEKDNAMIDDMLQNCVIDLRKGQGAEEAERSTETLELAVEQFVEDVRDLLEHCDRMLEPRMELIRQLDSKGVQYIGRGNRRLTDVLLGNGGSSTNAASTLHFVLLYSESRTAPPVAVGGLSSQHNGEKFYRQCLGQLYQMAGRGRSCAFVDLDALEATGYDGLPQGILALDGFPNIDCRLVKMRGHKLLTANCVTEEAQKLQICIARIENSQRTEVGAVPRKKTEPCSLPCPLSEGYGGKCQNNDFLWGCDDCGQTLAFVKTENAPMTHFYCACGATPVEEFTFRCNDVEAHGNEFKHFAKTQLTNELERLKSKGILTILLLGETGVGKSTLINAIVNYLKHPTFEEAIQADEIESVIPARFCTEEYDAGKLVQKEVFIGKKSKNECLEAGKSQTKWPKAYITPSKVGYKIRLIDAPGICDTGGIKEDNLNLHKTLSFISTLPELHAICILLRPNSTRTGPAFKYCINGLLTYLHKNAANVSIPLIQDRIYCLDNEAFEHLCLIKKANVRYSAENMADFSKSWTRAEQELQRMLKNVSELLPHRIWETVSLNKAHRTIVDLTYPLASISQKIQDNLFRIKEHEEAISKGEQELTTEPTFDTVQFVPLQYPRTVCTSARCTEVKKAAGEEIKLYRRHCHPHCYLENIIPENMPNESLKNCAAMSGSNTCKVKECGCDWSVHMHFRFDQLVVTQHLDEAKRKLFADKRDTLSTLEAYRLQMLHERDKIYSKALISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRS3</accession>
    <name>A0A914HRS3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRS3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3350.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3350.t1"/>
        <property type="gene ID" value="Gr19_v10_g3350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3350.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14015" checksum="66D7DF90D6D5C9E5" modified="2023-02-22" version="1">MSFKERLVFVLNTRTELASHCPTLPLCALSRVIEFSSKFWATAGIGRAFAVPLPPALLLKTALLEQVVHFGEVQCYIFFPQIAGTEVSGTEVSGTKVSGTKVWALKCAALKCPALNVGTEVCGTEVWALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS12</accession>
    <name>A0A914HS12_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HS12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g342.t1">
        <property type="protein sequence ID" value="Gr19_v10_g342.t1"/>
        <property type="gene ID" value="Gr19_v10_g342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g342.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="50075" checksum="C396C1B68869AD3B" modified="2023-02-22" version="1">MREIVHIQAGQCGNQIGSKFWEVISDEHGIQPDGTYKGDSDLQLERINVYYNEAYGGKYVPRAVLVDLEPGTMDSIRAGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDNVLDVVRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMSSFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLQNPTYGDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLSAKGAAAYQAMSVAELTKQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMREVDDQMMSVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFVGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQDATVDDEGEFEAEDTIQATAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS44</accession>
    <name>A0A914HS44_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MENTAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HS44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3729.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3729.t1"/>
        <property type="gene ID" value="Gr19_v10_g3729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019498">
        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF4">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="5">
        <location>
            <begin position="53"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3729.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15310" checksum="026932F8446CC8A1" modified="2023-02-22" version="1">MNEMPPTLPLPLHAEVVFLIILIIEHNPSALLLHNREPGRHEQGPYKNSSLEAFVEKVDIFRPYFLYNSLFDLAIAAFLRMSVLLVAYALIKCDHWFPVALTTAGTTIFVATKIFFFFDKDKSQMQQPFTSVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSB1</accession>
    <name>A0A914HSB1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSB1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3296.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3296.t1"/>
        <property type="gene ID" value="Gr19_v10_g3296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3296.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14442" checksum="63B297C06CACE71A" modified="2023-02-22" version="1">MEPFVKSDVVGLVKACVDFPIPELRNVFVAFDRDRFLEEKSIRWADEQCRQNGKEPSPENRREMLGPALYKIRFPIVPQEDFTDNIVPSGVLTSDELVGVYLYHCRANRALRELYPLKLSTQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT33</accession>
    <name>A0A914HT33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3715.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3715.t1"/>
        <property type="gene ID" value="Gr19_v10_g3715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3715.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7902" checksum="FABBCDCFDB9F3481" modified="2023-02-22" version="1">MLRSQKPNVVKENRPRKRAREPNVPTDDLVTEALNITEDDNEQFALMPTAEALTQRAETSFRTCIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTC7</accession>
    <name>A0A914HTC7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4278.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4278.t1"/>
        <property type="gene ID" value="Gr19_v10_g4278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="230"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="319"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="416"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="518"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="618"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="832"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="935"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1347"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1432"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1550"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1658"/>
            <end position="1740"/>
        </location>
    </feature>
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        <location>
            <begin position="2677"/>
            <end position="2814"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="3622"/>
            <end position="3802"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="3835"/>
            <end position="4018"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="4324"/>
            <end position="4422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2011"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2285"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2642"/>
            <end position="2668"/>
        </location>
    </feature>
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        <location>
            <begin position="3087"/>
            <end position="3126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3139"/>
            <end position="3187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3476"/>
            <end position="3520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2298"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2315"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2642"/>
            <end position="2651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3107"/>
            <end position="3125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3160"/>
            <end position="3184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4278.t1"/>
        </source>
    </evidence>
    <sequence length="4577" mass="498350" checksum="C4FE84C8E85D4147" modified="2023-02-22" version="1">[encoded data, 4577 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUC9</accession>
    <name>A0A914HUC9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4563.t1">
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        <property type="gene ID" value="Gr19_v10_g4563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4563.t1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38052" checksum="E74E9D9D4EA0FB39" modified="2023-02-22" version="1">MFKVKILFIFRFRVRTTRLRGQLAYGDNSPIGEYTATDNSATGTTWLRTIRLRTTRLRGQLANGDLGYGQLAYGNNLATDNSATETTRLRGHSATDNSPTETTWLRTTRLRKQLPTGTTWLRTIRLRTTRLRGQLAYGDLGYGQLAYGNNLATDNSATETTRLRGQLGYEQFGYGQLAYGNNLATDNSPTETTRLRGLGYGQLAYGNNLATDNSPTETTRLRGLGYGQLAYGNNLATDNSATDNSPTETTWLRTTRLRKQLAYGDNLATENSATETTRLRRQLGYGQLGYGNNSPTGTTWLRKTRLRTTRLRRQLGYEQFGYGQLAYGNNLATDNSATDGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUD0</accession>
    <name>A0A914HUD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUD0"/>
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        <property type="gene ID" value="Gr19_v10_g4269"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7083" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23309"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4269.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19100" checksum="35F7F317544FD5CC" modified="2023-02-22" version="1">MADLVQLLQQLLTAQAEQQNQFSQALQAMITPEKQNAELFSTINTQVSEFMYSPETDETFHTWYERYGPYIETDGSALPDTMKVRYETFTMRKAPSQSPLDFATQVSASCEKSKMDLTRDEVKSLIFTTGLGEEDRDLRERCLKLMEDARQKGAAIKFSALVEECRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWT7</accession>
    <name>A0A914HWT7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWT7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4505.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4505.t1"/>
        <property type="gene ID" value="Gr19_v10_g4505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4505.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29443" checksum="2B739BF47F32AE79" modified="2023-02-22" version="1">MYFRLRVGPGTGSFGKSRTGVINVAAIYRINYTKIDMINTADELSASSSSSSSLESKDYWVKKCLDLAAAKNAAEARIEQLKQRNVELELENRQIRESKVRMQVRVEQEEEYISNMLLKRIQKLKTDKEQLAQKYEQEEEFLINDLMRKLTQLEGERDELANRLSTDQSWVVANLLQKIRKLEAEIQNNHKSLEQLRREKVDLENSLEHEQEALFNTLGKRMDSLEAEKRRLQGRLDDLEGAGGAAVAAAAIGGANGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX58</accession>
    <name>A0A914HX58_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HX58"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4958.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4958.t1"/>
        <property type="gene ID" value="Gr19_v10_g4958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4958.t1"/>
        </source>
    </evidence>
    <sequence length="718" mass="80426" checksum="9FAD15BE0742D72A" modified="2023-02-22" version="1">MWRRIFYLDVGLKHKTYSLFLYAEGLNRAQRYGELGRLDGFPIVFVPGNAGSGRQVRSLGSLLQNKTERLGTPFQFDTFALDFNEEMTALNFDYIESQAQFLSDSIDHILSLYSSPHISPPKIVLIGHSMGGIVIQKLLATDSKFDKRQNIAFVVAFATPFAQPPFMFDKRGRRRALIVAGGKMRFRTLSHAAIDRIWAEADHLCIVWCNELVRQTSRFLFDYAAAPTHFLHNFHDFAHLHYHSLGVRLSPVSPDSASLSDVNISLCVPKCPLNSGPQQIDLLSNNIPSIGKQRFLLAIAHLTDRNHLSSKFDLLTLPNCGQSVGARFLDAAHLFAFFNLSNCVAQGKVLIAGGAHLWVFDDDAILLPQVNLSFIQFLWNGNKFTMRNFSMEMRPLAIVPIHFPRKENEFGIFKVQILRRKCREKSVARQRIVFLADGVPRRFDKFGTDSNSSALFIYPPTKGRWPNAEDTGGGQHHQLMIIDTAQCAEYSLVFSIGLHFSLIKLFRRSQHFLPTSSVFTLLLVHFYVSTTTGRRHFMNFCAVPVLMSAAIAFLGTDVFLLLLAVNSAVFLFFHLLLLTVSPLVLALFRRLFGPFASFAAAAAAAHLRIILFLLLALSTAFTNNSYPLALFCVCLHISALHRRFASGGNAVAFSSASLLLILPSVVFQFAHIFTCAWNLAKFGQFRALSDPFLATNLTLSLFTLASRFRTPIKLFGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXN1</accession>
    <name>A0A914HXN1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXN1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4983.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4983.t2"/>
        <property type="gene ID" value="Gr19_v10_g4983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF248">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4983.t2"/>
        </source>
    </evidence>
    <sequence length="328" mass="36682" checksum="249BC2AC96ED2EDA" modified="2023-02-22" version="1">MICLLVGVPLNLLLIWLLLRRTSKEMRVYSQILVQTCVVDLLVLVLGELVQPVFFVDNGIGHDLMAGPLQIVPNPANHIVFMLWFGLFYFSTEGLAVQFVFRYLTICRKMPMNTLKYFALLTVALLFETVVALALTLSSYPGAQHQQIDDPKVLLALGTQRKLTLALRSDSSDPFVVECFLLLFLSDTFIYATILICAVKIHSFLKRQFVEYKLSKWSELNGQITKTLLVQSFLPSVPLLMCTFGVAATIFALPSGNFLISAEMLITAPLCWLPLANPLVTILTVKHYRREVRLFGQTVLSLVTGTTPLANARKDSAQTAALATIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYH0</accession>
    <name>A0A914HYH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Symplekin C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5827.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5827.t1"/>
        <property type="gene ID" value="Gr19_v10_g5827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037203691" evidence="1">
        <location>
            <begin position="25"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="2">
        <location>
            <begin position="108"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5827.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33651" checksum="73CCD3EB6B885CAA" modified="2023-02-22" version="1">MPWDESLIRAGLFLLLSLLPLDHSLLNHLASVYARAGTEIKRMTFKSIEVAIKSIGMHSEELLNMINECPSEAETLVARIVHLLTERTPPSAALVDSVRRLHYSRNTDVRSLIPILTGLNKEELFKLVPKFVLSAKNSNSVPAFFKKLLFGRHIETNEPLITALELLLELHRIKPNRKEQGFLIQNMDILLVDANKEFTIGKDVLANTVETLLNDDPLPPVLFHTIQRIHENHPALNGFLSNVLIKIADKPWSDRVEGKESVWTKFVQCAKAVGVAGRIKTPEDFQTICDIPPIDQPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYL8</accession>
    <name>A0A914HYL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold-shock (CSD) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g587.t1">
        <property type="protein sequence ID" value="Gr19_v10_g587.t1"/>
        <property type="gene ID" value="Gr19_v10_g587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g587.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14677" checksum="B4585DE7774D4800" modified="2023-02-22" version="1">MGSVVFAILPVDFTSNMERLHSSNLWRPVTNSLKFLIAFPIVYHPLNGIRFMKGLRSFFVHHSYFSEMVSAENAYGFIQRYDTNEDIFVHGSFIVRFSVYTRERHPVLSKQQEVRPDSAKKGEIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ04</accession>
    <name>A0A914HZ04_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="3">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HZ04"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5098.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5098.t1"/>
        <property type="gene ID" value="Gr19_v10_g5098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF64">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036816013" description="pyrroline-5-carboxylate reductase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="9">
        <location>
            <begin position="214"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5098.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="35469" checksum="47EBF4E80F096F7C" modified="2023-02-22" version="1">MEMLQSEREAGGLLLSAALLILIVLSSEDRIGQLYLECFNEREKCMTVIGGGKMATALVHGLVATGFLDKSEVYICSKSKETAFRWRTQGYPTSYSNDEFYGKVKKPRGVVLIAIKPQMFPNFLDEMRLNEWFYFGGPELLTVSIMAGIGLGTFKQQLESVGFNGHAARLMPNVNCLVSAGIVLVSTDSNIPSEMATLLLELGSRVGYSIRIEESLFNAASALASCAPAYIFTVIEALADGGVLNGLSREVSLRLAAEMVKGSAQLMLNSPPEITSPAQLKDKVCSPGGTTIAGMRELERAGIRSAFIEALTASTRRASEMSPTTNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I003</accession>
    <name>A0A914I003_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I003"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5606.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5606.t1"/>
        <property type="gene ID" value="Gr19_v10_g5606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5606.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9048" checksum="011ED512BF27022E" modified="2023-02-22" version="1">MGIAHLRGPYFLASSVLFTTATISWVLWDNKNQTEKRTASVRSILMSAQQQRNMEEYLEQQQLYKQHKSDTTIPSTVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0S6</accession>
    <name>A0A914I0S6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0S6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5833.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5833.t1"/>
        <property type="gene ID" value="Gr19_v10_g5833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06970">
        <property type="entry name" value="NR_DBD_PNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000028">
        <property type="entry name" value="Nuclear receptor subfamily 2, group E, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="421"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="548"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5833.t1"/>
        </source>
    </evidence>
    <sequence length="770" mass="85460" checksum="400459869FED8330" modified="2023-02-22" version="1">MPKIGLGTENGGWVGGGGGGALIPPRPPSGHPPPPAMALIHDTDKCKQQQQQKQRREEELFRLLTVTSAAAAAVAGNFDGQEEVLGLSQHKQPKQPQTPSKGKLISALIANTRRCRPQTNEQMMPKKRNREKKPIPSKKKRKGRKRRRRTVKDNWRREEKEEEEEKKEKEEEEEEEEEEKKEKEEEEKEEEKDKEKKKEKEEEKEEEEKEEEKDKEKEEEKEEEEEERRRSKRLISSTSSVFTTPIPPGSSCRCRATNSLMLEQFKTSDGRRGGGEGTTCNSTTPPPAAPMCSLAAAMNAAMSAAAYAAGQQNGGGPTASTSPNQSNNHSHRPFQTNFFSNNGGTFADEFDDERVKILSDQNAAGIIVSVNSPIVQRSGSESVLTSPIGEENCGDAKGLSVSPRQQQNGSGGSAKNGTGGALTCAVCGDVSSGRHYGILACNGCSGFFKRSVRRRLIYRCQAGTGTCLVDKTHRNQCQACRLKKCLRMGMNKDAVQNERQPRNTATIQPIAELDGLYASHANLFRDCSTVFSSVDFMGRIPPKGTSLFTDKLEFRIAKQKNQQTDVLADNGKSNCITAEQRKDFTEMCARIMKVTVNRVRTVPSFGSVSIADQMMLLEHGLAELFVLTAFEWSMCAEECVIGVSPANLIISADLLRSITSLYDQFKRLEMNHTEIGCLKAVILFKPEAAALENATMIEQFQDQAQIMLQQHSMRLFPSFTRFGRILLFLPSLRAIVNCHRIESVFILPAFEDKTIGEVLSELLADGEDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1A8</accession>
    <name>A0A914I1A8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1A8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5964.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5964.t1"/>
        <property type="gene ID" value="Gr19_v10_g5964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5964.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13491" checksum="992DFAC6B14A29F2" modified="2023-02-22" version="1">MLMFNDLLDICWDIKVQLGYHSHSVYLPSLVLSAVYLPYWFYIDFINEHKMLPYGLIAFSAYALFVLPLFFLAMPHALFVSFEFDLLLALPIPSVAGTIFSLINGTFSKLWKGELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1F0</accession>
    <name>A0A914I1F0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1F0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5712.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5712.t1"/>
        <property type="gene ID" value="Gr19_v10_g5712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052742">
        <property type="term" value="F:phosphatidylinositol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037448285" evidence="4">
        <location>
            <begin position="24"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="52"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="6">
        <location>
            <begin position="546"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5712.t1"/>
        </source>
    </evidence>
    <sequence length="622" mass="70775" checksum="191FCEDB9F90CDDD" modified="2023-02-22" version="1">MISLPKALILAFILKFIIQFVLADPKNQLGFAYTSVSNERNYGRVVAGNILQFIVIGDIGGEEYESTVADSTAVKGTVANSTAVKKHRTTESQKAVAKAMDELSQANALKANFLLNTGDNFYANGVTFADVIPRFTENFEKVYHYESLDVPWYTIAGNNDWKGPDGIRPQIETPEGKWTFPAQQYVVHYTFENGVQVRIIMIDTTVLCGTGSSDFRKCKDAEKENEKDAKKENEKDAKKVTKKNAKKETEKNAKKETEKDAEKHAEKHAERYAKKIANAKKHFTWLRKELREAKRRRVNFLFVVGHYPLHTLDKQRAYPCAARMHALMRYYQVQAYFAGHEHNLKYVDLSNAGELGIDSIDTKFIVSGAGSRMENAISRRFPEAYIKFMKFLYPMNVGEVLKVKGEETHARGALDGGAFVGVEIDAKIMLAKLNFYAAGMFYNEDGTKKPIENWHKFEGQEVQMKPRRTDKTDENFDICNEFLEVGPQLVDDDHFKLDETERIQNILGTYFFYAGEAFDGLRKKLGIGYQKLAESFLSGDLVAQNPLGKSSSLFYRTSDKKFVLKNIHKNEVDTIKKTLPLFKMGEESSRIYLVFRINTEKNGTKDAHEFYAVTDGKTENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1S1</accession>
    <name>A0A914I1S1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1S1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6084.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6084.t1"/>
        <property type="gene ID" value="Gr19_v10_g6084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000651">
        <property type="entry name" value="Poly(A) binding protein cytoplasmic 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6084.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23922" checksum="BFEEAFC17CEB977B" modified="2023-02-22" version="1">MQRYRGANLYVKNLEDTFTDETLRKHFEPYGNITSAKVMCDENGRSKGFGFVCFDNTDAASKAVLDMNNKIIGIKPLYVAPAQCKEDRKALLASQYIQRLASMRLQNPTGILGTIYAPANGGFFLPQPIHNQRVVPFMQTPNLSGAQVRDVPRWNNVGGFNPTQYYMMGHASASSQYATNQVARGPRVGAIGSGRGPYGGQSRQQQQNRMPGMGGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I303</accession>
    <name>A0A914I303_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I303"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6138.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6138.t2"/>
        <property type="gene ID" value="Gr19_v10_g6138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6138.t2"/>
        </source>
    </evidence>
    <sequence length="401" mass="44344" checksum="65CDDBE817C54B03" modified="2023-02-22" version="1">MLEFGLGIAEFSTVALSKSTVEITYCRNQPLSKTHSTVQIKAEKIDWDKEELTKIVLRRLPPGIGPDDLRALFDPLSPEEPHAFWFCAAADDANDGDDAAATLRRARLCLSPNVLTATCSSTKMLMDGSAKERDERVDTLTNDVSFLKFLKRREEEAKDGGGPRRVTDFDELVRQLEEKRRRLDEGQVQETPLTEFIRRAALEKARKPVRRAALNTAEMPADSRAKKEHKNAAGGDCDKKAADDRCKTAVPKSSGRIKTRKPRRRATEEQKAKNDKKIADDGSKPSEVKSAAVQIKTRKSRRRGSALGTAGGKEDNMDIGTAKEQIAKKSAAGGGGDKKLLVATKDESVVIKYSRRNRDRPEREIYRPGQRKTTAAAAATTTRKQPRKTEEEAGESKNVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4C9</accession>
    <name>A0A914I4C9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4C9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7398.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7398.t1"/>
        <property type="gene ID" value="Gr19_v10_g7398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="323"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="585"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7398.t1"/>
        </source>
    </evidence>
    <sequence length="653" mass="72550" checksum="09C3EDB5072ED519" modified="2023-02-22" version="1">MNQMEASNNWDSRSPSLSSSACSSVRMINSEPPYSTASMNDGEAPQGEESELCLVCNDVATGYHYGTPSCNGCKTFFRRTLIKNQTFTCQYDGRCPVDKSVRCACRHCRFKKCLAVGMNKDAIQQNRDPIGYTKRTRRYPAEKKQKQQSPINDFSLTANNLFSSADMSVPSSSFSSSENHSMPDSSSLRGGAFGAAASFSSRSFTTSAASTPFSIDLPLLNLLVPSTAAADGYHLQLQQCQAAFTNSQLSSNFGTALSGFNNSNNGVGIAAGNNGQQQQMSTEQMQEDMLLRRLIGIEQILITIRNSKVCLKKTLNDMLVNDSVFDDAAMITRMSSETFQMPSVLRRAQQDDYLYWHERDWMLMIEWAKMLPAYQCLSVGDKLALLRHSAITYPSLLQCFYTPDVGSDTIVFPNGAFFDRTLNPTFSSAGFQRKNFKMFDNLLNPIRKMQIDKNEFAGAKAIFFLNPDSDADDLTTEAKQHITAARSAITNALYRYMVKKRGTEEAADKFGKLLLLGTSIATMSCEMKEAVVVADFFDQIRFSSFARQLLLDKDETDPMLIGGTVQSQQQQKYGDIAKMLSTTSATVPPNTRTCDSMTNNGLHRHSNNDGNQPQQNFSNRTNSPSNCSISNNPLPHPTTRQIRFEQIIAQLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I550</accession>
    <name>A0A914I550_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I550"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6704.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6704.t1"/>
        <property type="gene ID" value="Gr19_v10_g6704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6704.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14116" checksum="1A4B528143F34BDE" modified="2023-02-22" version="1">MPISTDSTNGGEDITAVDQEYLWPDSSEEVRLLRHRIAELERQQTINLPMIIKMELELKEFKQEMRAKNELVGTKLEQMEEWKRIAKLELQNPKSTFTLQQQHKQQEDEKLCCCFYLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I610</accession>
    <name>A0A914I610_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914I610"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7223.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7223.t1"/>
        <property type="gene ID" value="Gr19_v10_g7223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7223.t1"/>
        </source>
    </evidence>
    <sequence length="557" mass="61646" checksum="ED94E88DC2A10EED" modified="2023-02-22" version="1">MCDLSNNAAFSKLKNEFGVRAKSLQMAEEFEKDPCRAKKFTRSLLNGTGEWQLCVDFSKNRIDDAIFQQLIAVARDAQVEQWRDKMFAGEPINFTEGRAVLHTALRNRSNAPILVDGKDVMPGVNSVLEHMKQFCTEVISGKWTGWTGERIKDVVNIGIGGSDLGPLMVTEALKPYQVGPNVHFVSNIDGTHLAEVLKKVKPKSVLFIIASKTFTTQETITNAESARAWFLKEAGDAAHVAKHFVALSTNGPKVEKFGIAKQNMFEFWDWVGGRYSLWSAIGLTIAVHIGFDNFERLLDGAHLMDKHFKETPLEQNIPVILAVLGVLYVNLHGAETHALLPYDQYLHRFAAYFQQGDMESNGKYIMRNGQRVTHSTGPIVWGEPGTNGQHAFYQLIHQGTRLIPCDFIAPIKSHNSISDGLHHKILLANCLAQTEALMRGKSATEAEAELKASGMSGEKIKQIVPHKVFEGNRPTNSILLPEISPTTLGSLIAMYEHKIFVQGCIWGINSFDQWGVELGKQLASVILKELQGASTGKHDTSTNALLELVKTGKPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6P5</accession>
    <name>A0A914I6P5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GDNF/GAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDNFR family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7130.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7130.t2"/>
        <property type="gene ID" value="Gr19_v10_g7130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF12">
        <property type="entry name" value="GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="10">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="10">
        <location>
            <begin position="688"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="10">
        <location>
            <begin position="794"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="940"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1341"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="962"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="977"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1341"/>
            <end position="1354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7130.t2"/>
        </source>
    </evidence>
    <sequence length="1457" mass="164406" checksum="C1A104070187ACBB" modified="2023-02-22" version="1">MSQRQETRRSKRTTTGTAKQCYQQYIVVVREYSVRIPSETTFNIWSRPPARGVRNVAAESGMCARRNVCVGLNLISSIFSNILGALGPAGHSSSLPLDVPNLFAFHIGHILPLRLSKNRNRKWHSNGNANALLVDNDTVAKKMKAMPPAIIPWEIMIPITFLLLLFLFHSSHAAAVHVHAARRGSGISERLARSPDSDQIQHWKLAFSDDLAPSGRSRRLPKAVSCRWALNELCLRHVSCRELWTLFRRNCAVDAQNHCRMGNKNDCWQSFEGISWTGLGTCTCAGNNSDCHWIRLQTNYNKCIYELNNDAGWHVQLATAAQFSSRAEERVGEEEEVQRESVAVDTWTEERHHQHQWRAEEWENVRKKEEEENKETKQKAGAVEAGQGVDEQIKKERVEEEKRKMEDKERKRKEKQREGIEETQKKRNEEERRRRIEKEEQRKKRYEEERKRRWREEQRGKEENKAEERRKQVKAVERNGVEEKQMKSMESSEKKRMEEKQTEGRERHQAVTMASRRTTPTANNRAVYQTLGGRNDSQQHQPSIRSQTFKAGQAATAEESSSSTTSGAGGNMHKTKKQKMLAPEDAKKQIQHIITTTVVPPLQRPNFLPTAESQRLVTQAEQPPTTTTASWHWTTTTTTSAPTTTFAPKKSNVLMQHEHPPASVTGTEASSASSISINGSSSSTSSSCPAVLSLCDKDEPCRWHMSELRIKCGERSGACGLQRRRRAQCVQALHRFVQFVHAPLAQALVFCTCANDDANCRNAMFPFLHECLDEENWTQSLSGAIAISQPQWTCTQTMKLCRSESDCRRRLSSLRSACPIASSPHNTSVAQCAASSLSACRAALSATRGSWLDEACACPATAEEGTSCAELAESKWPGHPCVEMVRQDFNEQLRNGQIHLKTPAYPWHSSLPSAPADRHVFVHVGKLGGKGAMALGEEVTVPPSTEHIKETSSWTTKAGNRKPPTSSTTVVPKTALEENNNNNGTSSRPEGQQKTEVNNGDDHLVHIERKLNGVGQKKEVYEWAEDQEAQKLEEDDHDGEDESQKPNNNGTEIGLAKQKTVTKNGTEEWKMFTERLQEEKEQERKTVPERLQMNRNVLKTNGGTLRTAQSNKTGLKVHQIRPHRRQKTTKTTIKPLLDPEALQHFVTQKPPSEGESCTTRNVDGEWIAHYPDSVFRQYDDWAGRCSSWCECKLNGSMQCHQLGCVADVLCEARHTTIGFGQRLYLEDRGACQCHDGRFICDTSELMPELSAGLYITMGYSKAELDLIRQNVPKPVLERSGLISQSTSFAKDLAARLQFALERVLPEQTKCRVVLLEHFAQEEVLLMQLQWFGMEPNTTSSKNNVISSSTSNNKNDNSKPKWHSGKWEKLCAPYVRELEQNFLLERADRYQLLLSTIKQIRVIDLLEGLPQAFSSSSSSRAAPLGGLFVLIRSLSPEGSMLIIVQILFSLLIQLCTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I841</accession>
    <name>A0A914I841_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I841"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8358.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8358.t2"/>
        <property type="gene ID" value="Gr19_v10_g8358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8358.t2"/>
        </source>
    </evidence>
    <sequence length="570" mass="61608" checksum="3EBE7DF96ABCA18A" modified="2023-02-22" version="1">MVIRPSVQVHRHHHNQIVQQHHHFAAVPAAVVEPCQGNGMPMPSMTVGGQPNLGFFQPGTMPPATSLQHPAQAVHHAQLGVQLEQQLLLQRQQQQQQMVQQHQQQVLLQQMMMREACQYRPQPQFQHRPSLPPNPQAYHHQQTVGELTPPPSQPSIGALSSPQTSSGGSSSTSLSSSLLSGFNSSSNQSVPHHHFHSVGGVVHPTAAAAATELLQRQCQQMLLARQAAAAALQQQQHHVHLQQQQQQQHKSLFSAASSAPAPVPASTMAQSTPTAAPSTAAAASMLIANLVQQRNNNYSNNNNGSEQQSNMFAASINNNNGGGANDASRHQSTPNAASAQRQQYAMMEQAIKKEIYELLSSVAASGTPSNNGNGGVNVGSAADATTAQTPTQQPPSAVSNPDGLTTLQRAQMLNMLNLLRQREQQQQQQQVQQQMPTHGVTAVVQQPQQHYFQHDQHRLQQQFLSPPLTLSPSNSVHGDQQPLGGFSSVSPSVVVPTPPPLGDVQQQHQQQHQQHQHQQQQRLLMDGPRTVMAPMDIDLIEKQIAAQHNELSAQEAEAVAVLAGLAEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8H8</accession>
    <name>A0A914I8H8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8H8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g762.t3">
        <property type="protein sequence ID" value="Gr19_v10_g762.t3"/>
        <property type="gene ID" value="Gr19_v10_g762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036964866" evidence="3">
        <location>
            <begin position="33"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="541"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g762.t3"/>
        </source>
    </evidence>
    <sequence length="1097" mass="120495" checksum="7FCE578CD1E2364A" modified="2023-02-22" version="1">MCKRWVNCCIILLPSSDACRLLLHLLLAVALAFGNAKVPPPTVPSSSLLCRSSLLINISRSVLNISAGGHRAIVTEYWPPQGQPASPFTLHGPPRAGDANFTIQINGTWPAVRYQYQLNAVFGTGQRNGTTADTVLLHKGIAYSSPDKPVLVSAAATERACTLAWAPPPALHLPKAQQHASDEQLQQSVYNYYMEYFPVASSDVVFFIRTKENSVRLRKLRASTQYRLSLYAEYFGVRSLCPLELAFRTRRTVPRYGNRTKALLTASATTPRSVVSQTSTLPPSTGTVLQTASTVPTRIGTVMSRLPSPKTNPSSSSTTSTTPFYKLNSTVPTRIGTVMSRLPSPKTNPSSSSTTSTTPSYKLDSTVPTRISTVMSRLPSPRTNPSSSNTTSTIPPAQESVELKEISAEKSEENETAAENETEEDSSEAERGDGEEADHEMSPKQLNETEPSIRIRQHGTRTLALAWRVPELVACDAFLVRHRPLGSMNARVSTQRTTTLQALVPLVVNACLEVNVSCLFENTVSPQWSARRVLDLRTPAPVQSVRVIRSYTDEYFQASVLIGFTLPPKAGPAHFQLYEVHVAWAPGKKVVGNQRVVFRGENISATDGVGKRAEGHVNITGLEPARLYTFAVRNVSREMPSQCSAPLGVRLITPPVVTSTVYAGKISTNSINVNFGESDESHPFEQYELHFASAGDDDAAPMSGGGDKFKNGSTTLIRRLAKNDPKSFTFNKLVPGKTYTFSLFTLLHGVRSRPVDANITTYPLKVSGFHPLIGSGYVRLFWTVLNEAHNFCRFRLSYTASAGPHLHSALSLELNGTINTHRFSGLDWNTFYTFTITVIMGPPSAEAESESEAVTIGMANRPRSSPQLKRYGSRELLLSFENDPEAFPERNGAIKEFAVIVAERVALERAIVATTESYKKDNEEEAQNLLETLGDLWELPSWHDARERADDAGDDKPWIAYRTSPSNYNPFARRGSSRLAQFIIGAEDCMPGRHRLDEMYCNGALRANADYFVRVRAYSVEGIAMETAWVGIDGAVPHAVSGKQSPEQKRLPCYMYLNGCNGRERAVGSNAAARICPFTRRLVTFSTAISTIIMIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8P5</accession>
    <name>A0A914I8P5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8P5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8314.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8314.t1"/>
        <property type="gene ID" value="Gr19_v10_g8314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8314.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17709" checksum="1AB62B0FEC9EC7BF" modified="2023-02-22" version="1">MDRINRRLAKELTELITDPPAGIRFLQEQEGQTNSNLMCWTLILEGARNTVYEGEIFQLQFRFGDDYPFSPPEVLFTGENIPEHPHVYSNGHICLSILTRNHWTPALTASSVCLSILSMLSSCKKKERPPNDAAYVRYAPSSPSQTQWFFDDDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I915</accession>
    <name>A0A914I915_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-ribosomal protein eL40 fusion protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CEP52</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I915"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8608.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8608.t1"/>
        <property type="gene ID" value="Gr19_v10_g8608"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g8618.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8618.t1"/>
        <property type="gene ID" value="Gr19_v10_g8618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8608.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8618.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14651" checksum="4D4AAFBEB2B6ACCF" modified="2023-02-22" version="1">MQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGIIEPSLRMLAQKYNCDKQICRKCYARLPPRATNCRKKKCGHSNDLRVKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9G4</accession>
    <name>A0A914I9G4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9G4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8731.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8731.t1"/>
        <property type="gene ID" value="Gr19_v10_g8731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000013">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000016">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041980">
        <property type="entry name" value="KOW_Spt5_6_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057934">
        <property type="entry name" value="KOW_Spt5_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23288">
        <property type="entry name" value="KOW6_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23287">
        <property type="entry name" value="KOW7_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="13">
        <location>
            <begin position="200"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="1100"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="667"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="846"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="972"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="900"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1007"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8731.t1"/>
        </source>
    </evidence>
    <sequence length="1149" mass="126712" checksum="610FEB145A4A874E" modified="2023-02-22" version="1">MSSESDENSSVHSDAEEELGGGDVNESADEGEAEMNGEEEEDNDIGKKETSRKRKISDSEEEEEQLEEEEDFDENELALNKTKTKKKRRVRRRATARDFIQDDVEVDDDDEDEDDYDAGADGDDLFGVDPNERAEAERFLREQEKLKEKRRNKYADMTEEEMERYFQERHAAQVATHQGDLDEDAYDDITQNGLLPSTKDPNLWIVKCRLGEEKTTCLRLMRKYLTFMSTDEPLQIKSVIVKEGLKGMIYIEAFKMAHVAKAIEGISALNQFKVTMVPIKEMSDTLRVVKNIPALKPGAYVRLSKTLYKDDLAQVDWVDISQNRVNLKLIPRIDYTRLRGALRSQDDRVLKKKRRPLPAPFDLDRIKSIGGDVTNDGDFYIFEGGHYRRGFLYKSFPMNAIEDDVTNPTLTELEKFQESTDDLKKELESTHLREKRHNLAPGDNVEVTDGELVNLRGKIQSIDGEKVVILPEHEDLTEPLTLNASELRKYFKPGDHVRVIGGRYEGDTGLIVRVEDNVVIMLSDLTMGEMKILPKDVQLCAEVATGVERMGQYQYQDLVMLDKETVGVIVRLERENVEVLNMHGKILRKNTIQAGDTVKVVEGFLAPRKETDDERQGEIKHLYRNWAFVFSRKYHLNGGMFVCKARNLALIGGSKAAESQETTTILDNNQLMSPRPNPLESPRSAHGGMTPHSGSSVAGAQSVRGDQGFKVPSVVGSIAISANGVGRQSVRRNTEMVGKTVRVRSGPMKGYIGIVKDATESTVKVELHTMPKTVNFDINKVMEVGGAVPKDMMDTSGAMTPGTATFGGRTPMYGGAQTPMYGGATTPMHDSFGARTPHYGAMTPAYDGSRTPSHQPSSSWDPALANTPAHSTAHFDDEYDTLGFGGGGATSGFGGGGATSGFGGGGATPGFGGGGATPGDSVVEEQRRVVEEQRQDLVVEEQRQGLVVEEQRPDLGVEEQHQDLVMEEHRFGGGATPAGSVRSRYGGANTPAGQSTPRDMFGDYAQSPYTNQSANASPHPSKTPIRQSPANQEIMPNSEIPGGSWCMVDLCVNVLATCGKDQLLGLEGSIRSIRDGECCLYFEELDEDFTIEFEHLVPIKPAGGDQAKVIYGRERGASGSMITVDGEEGVFQGASGTRLYSMSLLCKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAC1</accession>
    <name>A0A914IAC1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914IAC1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8352.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8352.t1"/>
        <property type="gene ID" value="Gr19_v10_g8352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF68">
        <property type="entry name" value="PALMITOYL-PROTEIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8352.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="25899" checksum="D16A8F9CB762302B" modified="2023-02-22" version="1">MAASQIAPPIIIKATATHTASLIFFHGLGDQGDGWASVIKNEIRIPYMKSIFPNAQSRPVTLNYGMRMPAWYDIIGLSENSPEDNEGIEQAKNFVHGMIRDEIAAGIPSRRIVLGGFSMGAALAIYAGLTFDQPLGAIFAMSGFLLQRDRVLDEKNTTANRQTPIFLGHGHNDPLVPYTYGDMTWQALSIFNKNVMLIPYDSNVPEGEGQQAKASAAEKSKDGAGGGGTAGDSKVKDIGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAN8</accession>
    <name>A0A914IAN8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAN8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9062.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9062.t1"/>
        <property type="gene ID" value="Gr19_v10_g9062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038079847" evidence="1">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9062.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18687" checksum="BEF72476C154D83C" modified="2023-02-22" version="1">MESVATLFVLSAIIANLEHSAGLKCKMGDANLNSVETSKVVECPVGNNHYCVASICSREPSTAVILWACTNDDDKTSCAAGAKTQMQSMTQATDYSCNCTFGEKDKDLANAKFTLPQPGDQATKPDQARKSESNVLKPFELLGVPYVGEKAHFVIPLEKLHNRYGLQTLTAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAW4</accession>
    <name>A0A914IAW4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914IAW4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8901.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8901.t2"/>
        <property type="gene ID" value="Gr19_v10_g8901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14294">
        <property type="entry name" value="UBA1_UBP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="279"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="11">
        <location>
            <begin position="523"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8901.t2"/>
        </source>
    </evidence>
    <sequence length="680" mass="76826" checksum="A5E39A8FC0EF20C5" modified="2023-02-22" version="1">MFDIEMNIDTDAYKLFHSYLSEQKLYLKGPERAELVFKDECLYCFDTPFSTGGLFVSLHTFVGVCSQHIKLVAEKTSSRIFLNIQKFVELSEEPKDKKPCLKLDKEQQQIKTEYSLRIYPLFTVPLPITEGAEAGIPRICEEIIAHVSAELQQRLNSGISEWDGEERTVAKAAEDLVQLNYDGNGHAKAHFESTGFPLVVKLGTIENEDGDIYSYDEDAPVRDPWLAQHLAHFGLDINKFRKTEKTTLELELDANLKHEFSTIQEEGLQLVSVAGPGFTGLINLGSSCYINSALQVLLIVPDFACVFTEEFLLGKQPAEINEDFTAQLAKMGLKRSVAFVRQRFGELWGEDILNFQLQSSRTWRNMFAIFTRFVDELSNCVRYSFRTDTILSVAIPVDLIKESNIVVNGVKRKSVTLEGCLTAAFEEEFIDDYLSPVLRVKGRAKQEQRMGSFPDFLFLQLRRFTFDGTRGMRKLDVDVHFPDELDLSAFYSTGELQPGEQGLPEDADETSSTLSTNKPTCSEPNQKIVNELLLMGFTENAAKKATLFTKNESLESATNWILQHMDDSDLNDPHPVLSKQSVPPSSSSNQGQPTHKQETRNGSGRYRLRAFISHMGSSPHSGHYVAHVKAENGKWHIFNDEKVAESQHPPKTLGDCVISLKRVKRSFFALLWSFNCFKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAW5</accession>
    <name>A0A914IAW5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAW5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8272.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8272.t1"/>
        <property type="gene ID" value="Gr19_v10_g8272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8272.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13958" checksum="0161F233C7DABA0D" modified="2023-02-22" version="1">MSRPKSHRANYYTEKSWWITRKTRKFFMRFPGFEQILIVSVLFSLFAIPFTIKRRQLSRKRRELSDDEWADYKQRYNAVVEDRIKYGQHLYLPFYNSNSSQEQDEKARKSFADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAZ3</accession>
    <name>A0A914IAZ3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydropteridine reductase</fullName>
            <ecNumber evidence="7">1.5.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HDHPR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Quinoid dihydropteridine reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17869"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:17871"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:17867"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914IAZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8917.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8917.t1"/>
        <property type="gene ID" value="Gr19_v10_g8917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05334">
        <property type="entry name" value="DHPR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000157">
        <property type="entry name" value="Quinoid dihydropteridine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104:SF0">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8917.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="25484" checksum="1567AFA0CC5DD474" modified="2023-02-22" version="1">MAAQPGRVLVYGGRGALGTALVELFHNKNIWVISVDLAKNELAAQNILVDPLQGWQEQEQTVLTGIDGALGGEKLDAVMCVAGGWAGGNAAHKDFVKSADLMWRQSVWSSALAAKIGARFLKPDGLLQLTGAAAASDATPGMIGYGMAKAAVHQLVRSLADGKAAGLPEGTCSFALLPVTLDTPMNRKWMPKADHSTWTPLSFIAETLYRWTFEASPEERPKSGALLKLSTKGGQTEIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBH6</accession>
    <name>A0A914IBH6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial inner membrane protease subunit 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBH6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8407.t3">
        <property type="protein sequence ID" value="Gr19_v10_g8407.t3"/>
        <property type="gene ID" value="Gr19_v10_g8407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8407.t3"/>
        </source>
    </evidence>
    <sequence length="128" mass="15097" checksum="B0A2CCC83B8EA574" modified="2023-02-22" version="1">MAQKLTNTTVNRRCPPRTDSSQSFCQCFCAGQFHHPSAFIFFGTEPFELTNNWTGERLTLRRLNEYDWLLVRCPIVREEAEWAKWEKEANEWHEDRQWNWNCIDINFSDRHIGDGMADAMAGPSEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBI4</accession>
    <name>A0A914IBI4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8362.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8362.t1"/>
        <property type="gene ID" value="Gr19_v10_g8362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000009">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000107">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000006">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000064">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000117">
        <property type="entry name" value="Voltage-gated Ca2+ channel, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000095">
        <property type="entry name" value="Voltage-gated Ca2+ channel, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01630">
        <property type="entry name" value="LVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 16" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="10 16" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="175"/>
            <end position="195"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="259"/>
            <end position="284"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="358"/>
            <end position="379"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="707"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="955"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1080"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1150"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1191"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1223"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1288"/>
            <end position="1308"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1379"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="19">
        <location>
            <begin position="1538"/>
            <end position="1572"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="86"/>
            <end position="105"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="461"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="2020"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2179"/>
            <end position="2203"/>
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        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="461"/>
            <end position="470"/>
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        <location>
            <begin position="750"/>
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        <location>
            <begin position="1631"/>
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            <begin position="1804"/>
            <end position="1818"/>
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            <begin position="2042"/>
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            <begin position="2182"/>
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            <position position="372"/>
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        </ligand>
    </feature>
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        <location>
            <position position="688"/>
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        </ligand>
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            <position position="1053"/>
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            <name>Ca(2+)</name>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022568"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022673"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023303"/>
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            <dbReference type="PIRSR" id="PIRSR602077-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
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    <evidence type="ECO:0000256" key="17">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="SMART" id="SM01062"/>
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    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8362.t1"/>
        </source>
    </evidence>
    <sequence length="2216" mass="246850" checksum="AF4E97053B7557D7" modified="2023-02-22" version="1">MLLSDDGRAGLPPQTAGGSGSGGGGTFNPAFRTSTSQEGGMVPLGEDAALAHGSPPLSGSALTTTRTDLWQQTLQANTFNGAAVAATAQPESRRRMQSRKPLRQTPVERNERSLMCLTVQNPIRRACISITEWRPFEWLILMMICGNCIALAVYQPYPAQDSDMKNTVLENLENLFIVVFTAECVIKVIALGLLFHSGAYLRNAWNILDFIIVVIGLISTVLSRINIQAFDVKALRAFRVLRPLRLVSNVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHATCIDSVTGELAQKDPSTCGFASSAYHCEPSSASAIHSVKHKWLCSTNTTWMGPNNGITNFDNIGLAMLTVFQCVSLEGWTEVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKANARGLFQKFREKQQLEEDLKGYLDWITQAEDIEQLGDDEHSDEHGGESGLGPDGEDDGEHIDGEGVAARPSFLLTQWRTLQRMNRRCRRGCRRMVKSQTFYWLVIVLVFLNTLTGANLFFVVLFTMEMLLKMYSLGLLQYMNSQFNRFDCFIVISSIIEFVLVYFEFMKPLGISVLRSARLLRIFKVTKYWTALSQLITSLLSSLRSIISLLLLLFLFIVIFALLGMQVFGGRFNYNPMQQKPRANFDTFIQSLLTVFQILTGEDWNTVMYNGIESYGGIGSLGMLVSIYFIVLFICGNYILLNVFLAIAVDNLAEADQVMNAKPEEEEDEMEVEGDYEDDEKYDHGDEADEGEADDDTDGGEPEEVMVGARPRRVSHLGAQSKQKPIPKSSSLFILSHTNSFRLFCNKIVNHSYFTNSVLICILVSSAMLAAEDPLQAQSYRNTILNYFDYFFTTIFTVEITLKVIVYGLVLHKGSFCRNAFNLLDILVVAVSLVSFVLKSDAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFYCNDASRMTEPECRGDFITLEDGDTTRPVRMTRLWQRADFHFDNVMDAMISLFVVSTFEGWPDLLYVAINSNEEDRGPVHNARQPVAIFFIAFIVVIAFFMMNIFVGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRFQYRVWWFVTSQFFEYAIFIIIMLNTTTLALKHYPPDPEMDVVLDVFNLVFTGVFAFEALFKIIALNPKHYFGDRWNLFDFIIVLGSFLDIIYGKIGGTGSNIISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQVFGKVALDDDTEIHRNNNFHTFPAAVLVLFRSATGEAWQEIMLSCSDREEVKCDPASDDYKRDPNAGCGVNFAYPYFISFFMLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTDGNIDEANEQLRAAIRRIWKRTPMKMLDEVVPPAGKDDEVTVGKFYATFLIQDYFRRFKKRKELEAKGMAAPNTHAMALQAGLRTLHEIGPELKRAISGNLDPDFVHEAEEPQHRRTHTLFNNIVNALGGPTAATTGPNNNNNNDTKTGSPEAMMMLGSPTTPPAGMDGTLMMGGGGGEQRRLMPLKKEGLSPTHSIATADLMSVQYHHGSSLHRGMPTNKSVNLPPSHKAYAQQQQQFDDEIPIAMIGRPAMPPELLPVDGRQHYHHQQQQMKVNGSTRTTGVRRRLPNLASIYGARRGRTDSQQPLNDSNDSSLGNGAWGSSAVPSGVAVVNDAFRASGDAGGGGGPPAYAGHFAAGRADAAPPTTAPAGQMRQFIFVNRSMPTDSDEEDWWERRRRLDMEESSRVGGAGGGAGGTSASPPHRRMDGGGGGASAAARRSAAAPFASRATAGSGAGGVHAMAGLLSDYEDTYEEDTYRPDPTGRPVRLPYMPSTRTVVRPIDIEQYGGGLSAVAGAGPAAQYQRRHGGGGGYDEQQQPPMGGGAGGGHGAVHHQQQQQQQPRRRRILPVQPSADGRHPHYEDHRTGRNVLTDRLVGDALQLGPYHDAHVVEVARRELAEAYQLDERNMDSAAYTYLEQHLGGVCPEDIQDINKYSQHALMRPVEVDDVDEDELVEHDEGTTTTAAAGRGRTVGGGGEGGHLQQQEDDLLLVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC31</accession>
    <name>A0A914IC31_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine-rich DPF motif domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDPF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IC31"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8821.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8821.t1"/>
        <property type="gene ID" value="Gr19_v10_g8821"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042426">
        <property type="entry name" value="CDPF1"/>
    </dbReference>
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        <property type="entry name" value="CDPF1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849:SF1">
        <property type="entry name" value="CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849">
        <property type="entry name" value="CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C6_DPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01995">
        <property type="entry name" value="UPF0595"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich DPF motif" evidence="3">
        <location>
            <begin position="49"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8821.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18923" checksum="74863CB7A451937A" modified="2023-02-22" version="1">MTISIIAFYKMSHQTKDFERPEIEVKTEREQKSAVTAIGSSSAENLEEFRCANSDCQLSVKCCYGKLEFEKAGYKEQCYYMRNPFEPPNYHKSHRDYSIDDFIVVGSRCFICEQQICVDEECCLFYKHTYCLRCVWREKNSFPNELVAQAAKSLRSEKGKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDK9</accession>
    <name>A0A914IDK9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">eIF-4F 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDK9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8916.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8916.t1"/>
        <property type="gene ID" value="Gr19_v10_g8916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000014">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8916.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28753" checksum="CEFC48D8217E06CB" modified="2023-02-22" version="1">MSVDSNAKSSDESAIINEQQPKHNFQLTQLVPNVPLRVDEHSLEHSYVFSYFMRPQGKFDPEDYAMYVQPISKISSVEQFWQVYRFIKRPSEITEKVDFHLFKEGVKPVWEDPTNRNGGKWILRLKKGLSSRIWENLLLAMIGEQFLVGDEVVGAVCSVRNQEDIVSLWNRSADSLPVTNRIRDTLRRVLNLPTSTILEYKRHDDCLRDQRSYCHTSASVGQQAHPHHQNHHQQQQQQMGAGGGSRGGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDW8</accession>
    <name>A0A914IDW8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDW8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8994.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8994.t1"/>
        <property type="gene ID" value="Gr19_v10_g8994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="121"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="208"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8994.t1"/>
        </source>
    </evidence>
    <sequence length="831" mass="94236" checksum="5FCAA344780DF478" modified="2023-02-22" version="1">MFNPPGTVLIQEPEEVQREVIAASSSQPSSATEELAEQPPEQNRVIVNRRTSAQLHLTRTDGQQEQKKKNVTARPSYSSLRTNIIRMTPESMKCKLYCKGTKCIYCNPENWTECQQAIKGLYSNWITDEILAMARPTSRTFEEFGLIKQLKRLGIRTILNLQCAKEHDFCGPPLIAHTGFTYDPEIIMGEKVYYFNFAIPDFGTASSKSILDICKVIWFSLTYGRTAVHCHAGLGRTGTLIACFFVWSKGMSSSNAIEVVRRARPNSIQSIDQINVVEEFEFHVQKYGTALPSIFFANNGIPLRELMINQRQFLPSDEARRYAHIPKVIYLLCDRLLRKVFGKDGFQYVTPNAHHARSCTFGTIFVNWQNAFTPSGKLQVRQMVTAFARITAFPYEKDQALINHFQQLSLIKAESAIGELETRQLIMLLNAFLEAIKRPYCSRRSLIDALGHFSPDNPTVLPPTDQEEEEVEFVKMLMNPVAHYAEIDDLLGLLETNSTECQTSNSNENKCKDDNERQVDEPIKCVEAVNAAVDEQQIKMEQEIEAVIQIAERVQNDQTSEQEPETAKQNIHTSEGVHQVEQKQKSDNHEVSEAFPNPVTLQHQTLQFELPETVPKDLLEPQTIRQESVNKTELVAVHENGQVNGTEVAVFGTETLQVKEVEEAVRPQSGAAVFTTKTCAKKYGGVSIEQFEKTANEAIDGKTEKENFQSTSSSNSSQNPNGTVSLTTGQKQLEITLDNYDLHTNKSANLNADWQCVVFYVCNVISFLTGENYDTLVDLLTFWFTGDNNRDVKQAVYCHMRDLFARNMRQQEQQAAEWRRRMGHHSLKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IES3</accession>
    <name>A0A914IES3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IES3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9227.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9227.t1"/>
        <property type="gene ID" value="Gr19_v10_g9227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036972645" evidence="5">
        <location>
            <begin position="28"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="319"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9227.t1"/>
        </source>
    </evidence>
    <sequence length="645" mass="73520" checksum="2AE21B7E60B18095" modified="2023-02-22" version="1">MFQLLLKSKIFICIIISFTLNGHKCNAIKCQKDPIATAKDLLDSAQKAFSASDRQISEELLQNLKLEEINVNLLKTELSNFSNENLNKLTTLFYLGLNEFFTSIKASVGNFGKNKDLASVVGRRRKRANFLDNFKDSRTKIVHSLRNDGTRSNLKSGENFEVKVNGELEQHALDFSVFVETDANRSMIISNQVFLFKPDFSRRYLINLGSFEPQGLWWNRRIFIETEKDSGNYHAFLYAHLDKENSEIQKEFLAYETLAKINDENASNSLSEYRLSIPINLTRFFNNKIIFIELNIYQYEESKYSLDTLKIANATKDMCTICLEPIIESQFIIKLHGENGNKSAHIFHKDCIKSWFDNCIEKLRCPFCNQALKSVMTAVVPPRFESVSGEEPFRPFFPSGQFSFVFKSFSTEKFQGVQGVIWELELGLVLKLRRCCAACYYPASPSPPLKHYTTNTGIQHPPSDRQPCHANGSVKREFGGRTQPQSTFQPCGTSTAFAINHCSSRTSPRSLAKFFCVGDHKESPSPRTFAEQTVRRPLGSPLPIPLSRPLWWPLTNKRFIEHCSAILRSELPHTFAVALETDAFDTHASVVNAIKCQKDPIATANYLLESAPKAFSASDRQLFDELLQNFESGKCWHKWRSFGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF94</accession>
    <name>A0A914IF94_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IF94"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9347.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9347.t2"/>
        <property type="gene ID" value="Gr19_v10_g9347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037125523" evidence="3">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9347.t2"/>
        </source>
    </evidence>
    <sequence length="418" mass="47730" checksum="88FEF93E3353ED97" modified="2023-02-22" version="1">MSFYIIYLFIVLAFKAIFVESQPKESSDLYEKFCAVLDDAHRVRNGKEWLKLRENNKQPPTEDKNGAFAEWSYRYYSIERFFDYCYFLKNAKDCDFSMQNKTMKRREPSESINQSVCKCNISDCYDGTKFRHIALKPEFQYERGDPMSIGDAMRKIVDAYKSLAPGKLQQNLQRLYKNPTPKQLPKMDFCNKEDCIKVDAWVYYAKNGGDSDVATSKLKEIQKHLLKNVPLNLKEFPPQPPQNKQQTAEKPKTKLQKYPASSSSSPRGQHCSYHTDYRQTVLVTLEHPVQATTVGVLEVAMVEVVMVAMALMGSIVILVIWIVLPVRGSSLLTSSFLRGSLLSWMWRNAAIFNAVKSIRWHWFCRSNCRILAFHFIGEQSGIGAVNLAFHFIGGPSGIGVAVQIGTFWRFIASAGTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GNT9</accession>
    <name>A0A914GNT9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GNT9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10045.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10045.t2"/>
        <property type="gene ID" value="Gr19_v10_g10045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433015" evidence="1">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10045.t2"/>
        </source>
    </evidence>
    <sequence length="477" mass="55085" checksum="7133EADB9D4D7BE6" modified="2023-02-22" version="1">MFGPYQLLILAVVSSVVSSTEVKTTKYSQPFPLDMPVSQTCKEKGQAKCNGTCGWAECVATYLGPLLDFPVAVRKKPLPPLPDFALNAECCPAGHEFRCCEMPSNRKYTWVQKNSNEMISALDEKPECKNKEYCACEFSNHHRMMDGMCCSEDDKCGCCWTFFKDPIISKLPQLLRVPKKYGEKECSQGKTDYPTATCKRTEGWPISSCCDEDYRLKDGDGRFVSYQSRLFNSRLFEWRFFTNPYYEYKYWQHIPRYAWNTEKPHYWRIDGVTLDKDLWGPGYSDGILKKGSIKTVDYAIVGWYWVPRVVPPGTGELPVGRMFSWKKENTADMVGALDKDQKCKDKPVYCACDPLHFDQIMKGMCCDKSTRCECCKTDPTLSKMKKVMAQDPKTSSSCKDQIKANFGEKPTFCQWTEGWKQSAECCDEDYKLLTPRYAIIEGADRHYPLCRNRLPWIYTEICAYEWYWVPQVIGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPQ6</accession>
    <name>A0A914GPQ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GPQ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10284.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10284.t2"/>
        <property type="gene ID" value="Gr19_v10_g10284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15285">
        <property type="entry name" value="7tmC_mGluR_group1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036719192" evidence="13">
        <location>
            <begin position="17"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="760"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="835"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="609"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1111"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1162"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1111"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1213"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10284.t2"/>
        </source>
    </evidence>
    <sequence length="1247" mass="137472" checksum="F4EA7D5F81EA17F2" modified="2023-02-22" version="1">MLYSHVTLLMLRVVDVITKTSVQQSAKMLVGELPGDIQIGALFPMHRQIAGSEGCGAIWEQYGIQRAEIAMLTVQELNKVLPFRLGISIRDSCWTERIAMEQTIAFLREGVTQCSCCQTAGCQKKDNPVVAIVGPAKSSTTIAVQNLLQVFRIPQIGYSATTTDLSDKEQFGYYLRVVPSDAWQAMTINQLLMHFNWTYIAVVYSAGNYGEKGFEAMERLTRSGGSDVCIAHAQKVKSLGEPTEYRNALRALNQLSRRPQVIVCFCEGMALKRMFLAQKALRLEASESAAAANGNNTTKNRIKGRGKRRYYQREFQWIGSDGWADRLDVVEGVEEEAAGSFSIRIHSPNVRTFEPYYFALNPHNHTRNPWFREFWQQKFKCLLTVPKDDTVSRQCTGLESLASGYEQDPKLSQVINAIRVVGFALREMYNDKCPSSRQNVSTSALLNAQFESPCPEMETINGTLLFRYMMNVSFVDEFQQEISFDASGDPPAWYDILNYVGGDHFRLAGDFRQTSDGSHRLRMLQKKLMFYDKTDVMPESVCSKPCGIGQHRRQSTACCWTCEDCLETQFVNASTSECNDCPLGQWPEQSHRQSCKTINNEYQSMAGPAQMAAIAFASVGILCTFLCILVFVNFNSTPVVKSTTRELSFIILGGIVVCYLCTYVLLAPASDVVCFFTRTVPPIAFSAIYSALFTKTNRIARILAGSKKRILTKKPRFLSTFSQVVITWALVGVQCAIVAVSVMEEMPQSGHDPHFMPRRMVVICTYSTRAFLAPFVWNFILILFCTLYAFKTRNLPENFNEAKFIGFTMYCTLVTWGAFVVLYVNAVNKALTASFTFSLSASIALCLLFFPKIFIILLRPEKNVRSSYTTTKLIRCHFGNSQALNDSKQFSSSKTRNSSQSLSLGFTVSCPTRTASLHVANYNSVAGSPTCQHPRKDAFVQTELSTIICSSHQPQQRRQAGGGASGGFARFTRTFSVMGGTAAGAGGGPFRSGAGAAGSPGPISAITTLGTPPRDGSERLATPLSLADFHKAEKKSRRRTLDDDVMELINSCRRYQDERLLINPSTIHNMLLEEPEEMIAGGEETPPLTDRRHSGEKVTQLLAGTVRTLAQTVSRTAAGTPTSPGADGTGHAERQQQLETANIGSPLVWNSTNATSSLELQCPGDVSRATPTRSSLKGPSAVGNGSDSARSGGQQHHVEFAAGANTAGREQLNGETATAQSTTDDSFEELLRSRGIHPVQISRATQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRZ4</accession>
    <name>A0A914GRZ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mago nashi</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GRZ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10636.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10636.t1"/>
        <property type="gene ID" value="Gr19_v10_g10636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10636.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18271" checksum="7935A68F393EC936" modified="2023-02-22" version="1">MTSTKEGSVKREQFYVRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDTLIRKECYVSKSVMDELKRIIDDSEIMNEDDANWPEPDRVGRQELEILSGSDHVSFTTSKIGCLVEVNDSKDPVGLRSFYYLVQDLKCLVFSLIGLHFKIRPIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS11</accession>
    <name>A0A914GS11_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10654.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10654.t1"/>
        <property type="gene ID" value="Gr19_v10_g10654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10654.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="22851" checksum="981597E075868C76" modified="2023-02-22" version="1">MNAYQQHQQQQLLQAYYSQFQQQGTAGAVGADGQLPAKYKSTLCNIWLMEGTCARGKQCHYAHGIKELNYRQDDTMGRYYKTSLCNFYQQRGFCNNGDQCRWAHGEAELRKMTTDGSSNGFANYYATSMQAMADGQDNNGSSVEAAAAAAAAAAASASVTSQQNNSTRRDSQVIGPQLDALLSQQTTAADSAEIGDDEGGARKRIREAAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS20</accession>
    <name>A0A914GS20_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS20"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1087.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1087.t1"/>
        <property type="gene ID" value="Gr19_v10_g1087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1087.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="14757" checksum="B56A7BB5E1934BFC" modified="2023-02-22" version="1">MDAIWPLPFDLVGGGILTFNGGRAGGQINAFGALSGSWAWEVNTCWLVDWLVKPATIGKQQQSEEPKLPEHNSLSVKCPLSTDHKFTKLSTSTTTVIPPAITSARICGAMRTVCSPTDGRTGGRSLLLALEMLINFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSG6</accession>
    <name>A0A914GSG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10795.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10795.t1"/>
        <property type="gene ID" value="Gr19_v10_g10795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10795.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15103" checksum="870A25F30D3619F3" modified="2023-02-22" version="1">MQHGVNSNRGLGEETSGPLNLKKKEEVELEVEKLEKKNKKEGVGVMKKKLSDAQSCRPDVHVARRAMTDGDDDERPEEEKDDGWQNDANPIPPKTPGSQQFNFNIPKFQKCHWDAWTTSSNPLFTHSLQHLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSP9</accession>
    <name>A0A914GSP9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSP9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11018.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11018.t1"/>
        <property type="gene ID" value="Gr19_v10_g11018"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6799.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6799.t1"/>
        <property type="gene ID" value="Gr19_v10_g6799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11018.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6799.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30712" checksum="503A43D59ED19213" modified="2023-02-22" version="1">MITDLTIQNACTAKCNDVYLCQHINSQFSYRTAFASLKFKIVNNFRRLQITAIASQPTNASGPLAQIVSWKWDGGTQKIEETVTLNRDKTVEIDCYSSTSIVIRILKNREVIENPCPPFSSPDDDLTVHIGDRQVTVSASWLMVVSPVVKRMLSVEMKEKQQRTLNLDATNVLVLLKLADYFQIDWLKERCEAHLINYVEIPLIERFLLIERYRLNNLKNFFLRCLNVVNLREFLKANHEQQLLSAGFISNEFWFELSMRLCDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTG1</accession>
    <name>A0A914GTG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11058.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11058.t1"/>
        <property type="gene ID" value="Gr19_v10_g11058"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6759.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6759.t1"/>
        <property type="gene ID" value="Gr19_v10_g6759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275841" evidence="3">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11058.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6759.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="17862" checksum="1AE1A0FFF4FEAA83" modified="2023-02-22" version="1">MLFLLDAGRRLSWCAAILFSFFRTASSCFGGGLGCGGMGPWAGGPGAFGWGGGLMGGAGADWSMGRGGYAAAPFLGAYGAPPYMTGAYAAGIYAAAPAAAAFIGPCCAPTAAFGGLIGFRRKRRRSSGGGDGGPPGRPTFVHAATIHYKKREDDAGLGVVPSNKTISTQTPKKLFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTH6</accession>
    <name>A0A914GTH6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTH6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1121.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1121.t1"/>
        <property type="gene ID" value="Gr19_v10_g1121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF78">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="3">
        <location>
            <begin position="793"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="891"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1186"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1121.t1"/>
        </source>
    </evidence>
    <sequence length="1218" mass="133274" checksum="18587D33821C3B24" modified="2023-02-22" version="1">MNGHSRQSPVATATPPQATLSQPPEGIGGGGYEEGGNRGAGGDTPQPQQVPLQQHSQRYQTHREGDSSVPRATFHLPPSTTLMRSDTIPPAQEMYGPTAGGAGGGGVIPHATAYQQTAPNIYPQGQATAIYQNIQQAQYYYNPANGHAYYGTTAPGAYMTAGMPQALLMSPQQHQQAYHQQQQMLAAQHMAAAQQSHPQGAMAVPAHHTAAVLMPTATSVAQIPPVSVVSGAGAAVVVAAQQSSTMAAMSATHGAVPPGTTHLPANVVVTSSATGQSIPPQQQLQREKKVLKFVHPDTQKELDLSSGAANEPKRKANSSVDGKEKSAAEETDKTISVKEFQKRVTERMKYGAGGDLKAADGNGRTPAATPPPSAAQITREGLERLDQTEQVDTVSDWIQTIPNQRLVYGGQASDMHISLDQQQQQQKDGQQYVSGTVANFVVQQQPPVHHHTQLLSTSPPIIAVEQQVIHPSPQSQQQPVPPVQQQRLSPVPRIQRLLDMNVVKPTMEQPVEVPEQQTVPKIVSAVVVLPLEEPPVVISPPVVISPAAEEEEEEAVPGDTETMGGGSRKGSQNDLNGEEESAADRLTPTQDGGEEMTEERIRELEEQMQLLEKSDENNDPEQFVYSRKFLYFIRKVTLALKTVNCPKTEDELEELGLSRRGMPTVQSFSAGGKAKRFDGASSDQFKTAWQQPGGGGGAGGGLNQFGTGSGGRFTTSRPPYSGRHSDNKLKPKKGPIARQSLDQRPLKLAQISSSQAAELSKRSSNAWKPKREERFDMSAPTRDEDEIKYEKLCKEVRGLLNKVTPSTYKDLSEDFIQYKIHDDPKLLEMIIDLIFDKAVEEPHFCPLYSDLCERQVEEEKRVMADKHDKQPQEKSFRSEIIQKCQKTFLASNQFDEKISDLKKKMDELDEADEKARAQVEEEIETRRSKEKRRLLGIIRFISQLYRHHLLIDLIINWCAVELIKRYEITKDEVYIEYAVELLATVGKVYEKRQDMPRGSVSMAQDQKVKMDSFSLEKIFGHLTSLKKDMSNRIRFAIQELEDLRQNKWMPRGGEKGPKTIEEVREEVEKEQQENEMERIEHDKQNREKMQQATRKNTRPSYGGRSSADRRSAAAANATSLLTGRADSRISTMSKLSEVDSFSGLGGGRKRWDHPRDRTPQKEDSGAGSASAGGASGAAGGGGGGTFSSETAWRSTSRGGTDSPKDSSGGHGGGGAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTU8</accession>
    <name>A0A914GTU8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hunchback C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTU8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11158.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11158.t2"/>
        <property type="gene ID" value="Gr19_v10_g11158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001301">
        <property type="entry name" value="Blast:Protein hunchback"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002883">
        <property type="entry name" value="Hunchback-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24392:SF49">
        <property type="entry name" value="PROTEIN HUNCHBACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24392">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="916"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="767"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11158.t2"/>
        </source>
    </evidence>
    <sequence length="969" mass="105420" checksum="AB6609530A73285A" modified="2023-02-22" version="1">METVLNSMISNMSALPPPMTLPVTGDVPSSSQQHQLSEASAIKIETTSAPSTTQQISSRACRNTTTPNSIGITSTGETTSNNGRVEQPQPQLHQFQQRNTGRTFFRAPGLEAPDENSGDFPTNALVCPDCGFSCSSKFHYNSHRNTHSTHQCPICKFETRTEGRLKKHMLQSHKREQRLAAGINIQSPPPMPATLKQHSPTYNRDSGGDKCLAQQIVVNHGMSSDGMSLLNSVLSAGDNSANGTLALESLQSMLNNTNPLVQFSNSTDALLKICTDAITNNGPTDKPLSNSPQMGDVGHIPLEQLRALTERHTALLTTSTTNSLNFGELQIGADMGLIGTDTNQQQSTQQNGSDEKQDTPRRSGKPKQYKCKQCQHISRSKKEQWAHARLHIPKQKQLTCALCDFVTEYKHHLEYHYRNHNGQKPFKCTICDYTCVNKSMLNSHMKSHTPVYQFRCQDCTYQTKYCHSLKMHLKKYNHKRAPGPSGFVDSSDSHGEERPENASSSSIGREDTASFENGAPMGALPSDGHPEGASELIVALPSTVHQHDSLLNGPPPGDTAELEMTSHRLMLQQQLDQMNGFIRNAMVNCPHCSYSTGNIDEMNKHLLVHLILAQHPMSTALNNEQHALATIYQRVTALLHQELIPGGEGAAHPHQLMPSPLSHHQQSVAHSLLSRALAMVTTGSQQQQKDDDVPMELSVSAPLPSTMTSEEERALQMEREAVECIRQQHAQVEQHAHFTPTTVVEILAAVAQPPSRVDGTTMMAATSSGAEVESVRGGECTTDGTSTTTPTSNNNEPSNQRQQLSYSTTGKSLKREFSFGGGTFQSANDSGGSTVMQEQPDRGRATAEGGATGTCVITNVMPRLMSSIPGLSNGFETRASAGEEETSAGGGAGYGRTVSGIFSGGVQGPSGITLPYFCQQCEIAFKDAALYQVHRGFHARESMFKCNICGHLSSSSLDFNLHLYQAKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU43</accession>
    <name>A0A914GU43_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU43"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11247.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11247.t2"/>
        <property type="gene ID" value="Gr19_v10_g11247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037792472" evidence="1">
        <location>
            <begin position="24"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11247.t2"/>
        </source>
    </evidence>
    <sequence length="769" mass="86205" checksum="95CD2B9B0147E797" modified="2023-02-22" version="1">MSKITKLVLVLLLPVAFYKPIDGYAKEYRRELYYLDFYLGIRPANEQGDLEVEDRSIDKYIESAAQLNCDFRSNCLWTNAPSDGLLDTSEFYLFSKSDRKAFPIQVGPGNAHPPTSTHFAFAGNLTKDPQSAVLIRGRENKDPPRGRYWLYNSARLEVILLKVNPVRGHLTVIERPITDCHFLKTNGICRVEIRKQSEPFRLAVRIFKLHDLAVGSFGMMTKVRYEAELSGFHTDRQSLADCPLLDARDEHFEECLWADFAKTPGTNTAHWAIGEHTQHWEQIMRSTPSSRPKGQFYFHAGALHSDAVFPFIQILAEFGPPSTNLYSDAPGPLTIDVDTADHQPFRFAFNVLRIDRGTNGGAAVIVLDDIRYSGWLCHESAPTAPPPRMPPFSSLLQLRLPPTAALVDTSQAFPDSLECDFERGDQCPHWMHSVSDLEIGESEEEAEELPDSQKFWLGLVPRQPPFPVDPSFRGAQVAVALLNRNAPEEQFAILTSRPISCAEKGRLTVAYFASPGAQLSVCANEQCVSPKRRRDADSMSVALNSAQPFRIRIIAELNNSMPIGRSDPYEPFILIKHITARSGFCRLASAAELACQALSCEFGTEGMCKFKTLFLAAGDVPFVVIPSAQAEGIVARFSRGMRRAILKSHPFRLPSSEQLEMHLEARLSTFGSRLYICPDEQQKTVSRLTMEKMGANGAETDPLREFGHCELLLGPKVDERRVERLVVQLDPELRHFSLVAVHDKTEQFGDAEVQLNRIEIRDAGDRPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU91</accession>
    <name>A0A914GU91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11276.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11276.t1"/>
        <property type="gene ID" value="Gr19_v10_g11276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000493">
        <property type="entry name" value="serine/threonine-protein kinase unc-51 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="84"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="601"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11276.t1"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112838" checksum="6D89E44E1C7E2414" modified="2023-02-22" version="1">MRKEAGREGRKEGLDSESGMGKEKEMTQRALSKSSLPDHFFHPLSIEFCLKTFTKALGHYTFIRTVCMLTSRKTHKMEEIEGFCYGGEVIGHGAFAVVYKGRHKETNKEVAIKAIAKKNLSKAKNLLTKEIKILQELKGLQHENLVSLLRCVETSTHVYLVMEYCNHGDLAEYLFSKQSLNETTIQHFFTQIACALEALNRKAIVHRDLKPQNILLCNPRHPLTPMSTQLVVKLADFGFARSLPEGIMAGTLCGSPMYMAPEVIMSHQYGAKADLWSVGTIIYQCLTGKAPFVAQTPQALKNYYERHMELKPNIPDFCSAVLSDLLMGLLKKNPGDRIEFNSFFNHPFFTTELPTSNASPSRHLVRQPSAELHGPTQQTQMRLKFPGSPTRTLSNCPNSPQRYGTAHQRIPSADGNRNLPQSARNAYAPGVLRRQVPPSAHARAPSHPLARPTSLDRSQNAANEARQLTQIHQTKTNSQQNLQHSGGSSTGSSENPVKQVQVHSSTRPKSNVGKAVPVPNKRRSHPMARQMSLEEQQRQGKGASVFGEDQKLKEPIALIPSVDEIELPETRFIVYEQHKASASRSALPVGPFSGRLRRNTAVTEEPSTSNPNRSDTSPAATIPKSSTCALPLSSVGGLQQKEAEKTTKRELDNIRFLNTSPPPSPSSIPFDETNVQTKPQIKVVNEPRGAESEIDEDEIGMEDPIQLPFTEEYMEESDVISQMAESVGGDGMEKHNETMKPATSVFDNGEMTANRTETATKTSSAGRNQPFPNNWLFDAPDPPPELEQETLLEAGHKQILAKLRFVLDLIEAIANVAENKANPMAIAMEGNKRRPQRQYQSDAYRRAEQLVLYVRALHVLSSALVMAQKQINAGLLHPSAAVQNVLNQLNEKYHFCLARSQELASLGIPGQDPQAMVVSAERIMYQHAIDLCQSAALDELFGNPHLCPKRYQTAYMMLHTLLYTVQNEQDKTILLKYKNAVEKRLRILERQGLCVSCYYYGIPQAEWFILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUL5</accession>
    <name>A0A914GUL5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUL5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11353.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11353.t1"/>
        <property type="gene ID" value="Gr19_v10_g11353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11353.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26761" checksum="800004C5C491D315" modified="2023-02-22" version="1">MVVTVKNGRHQQNERQQMTESELRHYEPEFCESDPKWKCWPERKHVQKVAFHASVSTVVLAVLLLLLALLLLRPLLLRLFFFCLSAILCVVSAMAFSANLRQNDNLFMPYLFVMWFLTILSFALFFFLLPMFAVPNFWQDWVLNGFGIAKGQHSESVVRLITVLGAVIAFVLVCLFTLLNFTMIRARNFLISKRVAIAKGYGGETHSTIESGRKKKRKKDDSRRVRVMETIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVM6</accession>
    <name>A0A914GVM6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVM6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11753.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11753.t2"/>
        <property type="gene ID" value="Gr19_v10_g11753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11753.t2"/>
        </source>
    </evidence>
    <sequence length="71" mass="8363" checksum="BC8F70328C1F6741" modified="2023-02-22" version="1">MLKPGQHNSLVSLIVEDGAHHYDLRGEHPADTESVRELDGLHIKRWIAEAHERQREQKRMVRERILRAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVR0</accession>
    <name>A0A914GVR0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVR0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11634.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11634.t2"/>
        <property type="gene ID" value="Gr19_v10_g11634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="109"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11634.t2"/>
        </source>
    </evidence>
    <sequence length="271" mass="31269" checksum="D54B6A4734F12166" modified="2023-02-22" version="1">MLNKRRPPPYGTPFSELEFTFHNETQHLQIRDIASRALDASGPLAQIVSWNWDNGRQEIQQTLILDKSGSLDFDCSIDTSIIVRILKKRELVENPCPPLDSMDYGFIVQIAEHHLTVSAHWLMCVSPFFYAMINRDMKEKQQGSVNLSATFGTMEQFLHFMDYISPNAVHGSYCPNPKTVIDLLVLAEQYQIEWLKRRCDEHLVNCVELQLVERLRFADIFHLPKLKGFFLRSLDVANLRKFLKANHAQLSSLSISNGFLWGVINRICDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWK1</accession>
    <name>A0A914GWK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11061.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11061.t1"/>
        <property type="gene ID" value="Gr19_v10_g11061"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6756.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6756.t1"/>
        <property type="gene ID" value="Gr19_v10_g6756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11061.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6756.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45649" checksum="6D1E9B3511834D1C" modified="2023-02-22" version="1">MHLYGATDQQQSPSEDRRTHQQQRQLQLLRRASATLGSGNLRDVVQLPPGEDLNEWMAANIVDLYNQVSMLYGTIAEHCTANSCPRMTAGAQHEYFWSDSKGVLMEPCPANLYIEYLLSWVQEELDDESIFPSQIGRPFPSNFMHIAQAIVKRLFRIYAHIYHEHFGLIEQLKAVEHMNTSFKHFMLFVNEFNLIDRRQLAPLQELIDKLLHINNAQQHQADGGKFCQIGMKLYAFVLIGLAVLALSSICNAGKDRDKKKYKTNEEAQIAHWNETHNDDDTLKQPQRGSSATKADSWNEVQEALATLPRKHTRGEASNSNQLAEQTQRMPPTNSPNQQATTASVGHSAQNPVNVSDSGESYSWPTNPPNQQATTASVGHSAQNPVNILHQTHPLNLGRKVVKRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWL8</accession>
    <name>A0A914GWL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11869.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11869.t1"/>
        <property type="gene ID" value="Gr19_v10_g11869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="185"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11869.t1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41999" checksum="A6D9115E34F545B8" modified="2023-02-22" version="1">MMEPTIAELSMPYDSTAATTSHMTNASQTEIRVEYLKHHWTVKNFSHCYQEYLENYGNGENNKDFQQNRLQNSEGRDIEMRIHPNPSHSDYVSYIKRDVLFPQIQPADSITVFVEIDVAVETVTTSVDDSCRLSKPCICEHQLGDDYLKLLNDGVLTDFTIRVVQEKDNGNDGGGKSGSSGGGECSTALQPQQNEVREIPVHKAILAARSPVFAAMLQHVDTSESKTGVLEIKDVECGVVKEMLNFIYSGKSSSPEINEIASDLLIAADKYRLEELKTHCEHCLIQAINFENACQLLIIADMYGAQFLRKRVLQFIMQHPKKITQTTLWHPLRNRADLINPICNSFPPALIICYSVACKNNPRWRCFLSAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXG9</accession>
    <name>A0A914GXG9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXG9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12263.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12263.t1"/>
        <property type="gene ID" value="Gr19_v10_g12263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12263.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38530" checksum="474FED720826D87A" modified="2023-02-22" version="1">MALCQKFGRLLIGAEARFFARTDITNFSTSLDQSPTPKQIHTRLPPGYNAPNAFALFTKDQLTGQSGGLKMVKIVSTNWKSLDEKEKQNYSERAKKIGDELRDNFEKLTDDQKKDLWDKHVEKMNKRRRLQMKMKLNKFHAETNRPKQPLSSYMLFVKERFVKHTEPFKTRDERLKFVVETGQQWRQMTDAEKKPYGDQAQGDRAEYRMELAEWKQNHADEIKAWKEANKPKAKAALKEKRQKKVLKPKKTKAAKALKRGSKQKKTKEVKAKAEGSVEKEEWSSDDEEEAIQQEKRQKKVQKRGRKPKKTEKEPEAEGYVENAAPKMTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY16</accession>
    <name>A0A914GY16_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein rogdi</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rogdi family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GY16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12198.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12198.t1"/>
        <property type="gene ID" value="Gr19_v10_g12198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12198.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34212" checksum="377A102F54F69F52" modified="2023-02-22" version="1">MENSDSTLGEANRNEEKARTESLLTLAEANWFHGVRTNPTFDQLQHLLVDCCRRLNAIHKVHYLPGVPKQDEAESKPSIERFSLQSRLEHESLSAVVTLCGQRVVQAEVSLKYAKSASGFYRATAQPEFHWKMQQLLDAANAIVRALQSLCQGRKKYGECVQKGCSTADNETDLHQFILSVFNAVKVDIKRARLALTMPKKKSLVELCNFHPIKSFVPPLPHDILLSFYLSSAKIVCAAYQVASANGRRIGGGASGLGGGVSSTQQTVTIFQAECLVPRLVDIVHLLNSAFAIAHNFTSNFCLSIARTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYE8</accession>
    <name>A0A914GYE8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="2 6">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="2 6"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYE8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11931.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11931.t1"/>
        <property type="gene ID" value="Gr19_v10_g11931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000082">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="7">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11931.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28971" checksum="ED3DF6F8701F72AE" modified="2023-02-22" version="1">MSNSRKSVNKKEKQNYFMTPKYTILLPTYNEAENLPICIWLIFKYLVGLNYEVIVIDDNSPDGTQDIAKRLQDEFGKEKLKLLTREGKLGLGSAYVYGLKHAQGEFVILMDADLSHHPKHIPEMIALQEKHCYDIVTGTRYTMGGGVSGWDIKRKLISRGANFLAQFLLQPGVSDLTGSFRLYRKKVLTQLVAESVSKGYVFQMEMMFRARKRGFSIGEVPIEFVDRFYGESKLGGQEIVQYLRGLIYLFVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYU6</accession>
    <name>A0A914GYU6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYU6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12599.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12599.t1"/>
        <property type="gene ID" value="Gr19_v10_g12599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="245"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12599.t1"/>
        </source>
    </evidence>
    <sequence length="442" mass="50471" checksum="9313C3F1186A529B" modified="2023-02-22" version="1">MLILTESINGDITSQDPSEELRLLRARIAQLERQQTNNSPTSSSAGFDLVPQNGKRRRIEGDEGGSKETNELLGKQLEQMEEWKRITKLELENKALRAELAHQKLLNAHNVLQTKMEEYQNKQQQTIDELTEKLKVSIDQFSLKHREHEKLLNAHNNLMEEIKEQRKMDQKETKDKICCLNEAQQKLSEGQRNEMRLEMNESLNSVQAMVATELEQQKVSNANKFAELEEYQKGQQQNISDLHKTVAAVLNDTINGGRGPIQQQNRWDSAACHDKLTLSEPERLIVEITGKDTWAWRSVLAERPIAKNCGIFYYEVKILVEEDGIHIGLGTKQMPLNKWVGFYKGTYAYEDDGTFWGHAVEGCSHFEGRPFIKGKPTFEEGDVIGCGVNLATRQIIYTKNGKRLETTNLFVDSADELFPCVSLSDSGDKIVAYFGPNFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYZ2</accession>
    <name>A0A914GYZ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYZ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12484.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12484.t1"/>
        <property type="gene ID" value="Gr19_v10_g12484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12484.t1"/>
        </source>
    </evidence>
    <sequence length="906" mass="98149" checksum="D2831D0FE566B084" modified="2023-02-22" version="1">MKQNEKTTREERSANCTFVNEKKNRERNWGKSFIWVLTFGRRVRLGAGGLGAGYVWATGAGYVWEPGTFGSRVRLGAGYVWATGTFRSRVRLGAGYVWEPGAGYVWEPGTFGPRVRLGAGYVWEPGTFGPRVRLGAGYVWATAPGTFGPRVRLGPGYVWEPVLLGPGYVWRRYVLATGRFATGTFGPRVRLGPGYWAAGYVVAPGTFGHGTLCPVRLAPYFLGAGTLGHGYFAQYVLGAPVLGHGYVWAGTLGPEVLGPGYVWPRYLLAPVLWPTVCAPLRLGPGYVLGHGYFGHGLGHGYVWAPGNVGPGYVLGARVRFGPRVRLARYVWAPGTYWATGGVRWATGDLGPWYVWAPVRLGPGTLGAGYGWWATGTLWAPGYVWAPGNVWTGTFGPLVRLGPEYVLGPGILGPGTLSTVRFGPGYVFGPCTFWRRVRLGPGTFGPRVRGPRGRLAPGYVWWAPGTFWAGYGFGPRYFWEPGTFGRGLFGHWYVCARVRLGPGTFGAVRLRATGTFGAGYVWARFGPGYLGPGTFGPRVRLGPGTFGPRTFGPRVRLGPGYVGPRVRLPGYVWARVRLGPGYVWAPVFGPRVRLGPGYVWATGTFGPGTLGPGYVWAPGTFGPRVRGPRVRLGPGLRLVPGYVWAGYVWAPRVRLGPGTFGPRVRGRRVRLGSTGTFWPRVRLGRVRLGHRVRLGAGTFGPRVFGPRVRLGAGYVWATGTLGRYVGPRVRLGPGYVWAPVRLPRVRLGPGYVWAPGTFGPGRLGPGYVWAPGTLGPGYVWAGYVWAPGTFGPRYVWARVRGARVRLGTGYVWAPGTFGPGTLGPGTFGPGYVWARVRLARVRCPGYVWAPGTFGPRVRLGPGYVWAPGTFGPRVRRLGRVRLGPGYVWAPGYVWAPGVWATGTFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ66</accession>
    <name>A0A914GZ66_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914GZ66"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12538.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12538.t1"/>
        <property type="gene ID" value="Gr19_v10_g12538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12538.t1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51083" checksum="6A9B2D25B073F759" modified="2023-02-22" version="1">MIHSDVPSPADCLIIIDKINTSKNWIEADEPGGDIVISAHFKTANKVKLFELTYETDGAKLVPSSDCPDGVNWNGQRNPGQILTCDGGGSPCCPKAGIKHPPKQTFVETIRASSKVRRACGIKAGDGKNDTKLFTTKHFEIEFKNIFKKCWMEFAKPCPDQTELIMLTMSRRHGFENRKGIRQTWMNDSVPGEVIRFLIADAGEGEAIDVQKKLEEEQAEHGDLVFLHGFVDIYAHIHLKWYGGLKWQQSFCANAKWVMKVDDDALVHLRRLAHWTEKKFRPIVAQNPLVYFGEIFHLSRPHRNPKSKWHASKETYPKDVYPDFMQGTVYLTTPATIKAILLHTRQIDGFYLDDVVYTGMLAELANVTLSDQDKHFMWRFDFDEKNGKCEDGVPTPFSIWGAEKLRVFEHQYGKMKSIECKNTRQLPPFSQNAFILLAIFVYYCVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1S1</accession>
    <name>A0A914H1S1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA 3'-5' helicase BLM</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NDRG family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13111.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13111.t2"/>
        <property type="gene ID" value="Gr19_v10_g13111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="213"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="848"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="898"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13111.t2"/>
        </source>
    </evidence>
    <sequence length="1400" mass="157802" checksum="510F1A6E8F768A25" modified="2023-02-22" version="1">MIPRMSGVPKQAITATMLGIDVFVQMPTGGGKSLCFQIPALEEKGVTVVISPLISLIRDQTMKMRNGTAIIPCAVYDAERMAREAFSKRMPAFKLLYVTPETAVRNPQFGKYLKYLHGKDLLARFVVDEAHCVIQWGNSFRPVFLQLGDFMQTFRKTPRKKVPILALTASSSKKDCRKAFECLRMDSEGSLWFQSRLDRPNLSYRVIPKSKMNFTQIIKHNLSTPGSGIVYCLTEKECRRTALLVGSDAKPYYSRLSDRLKRKYQDKWMDGRIRVLCATTAFGMGIDKSDETGRAGRDGQPANCVLMYRFQDQFRILREIDAMKCNSLFRKDKINELRTVVSYAEEHCNSEDPFTSPFNFMQNGAKETPIEDALVLFILSIIYETGKIKLPILHDLCSSQSQHLPATDYQKLIRRLILSGLLRMTLRFNPFMMCTAFVSLSFKGQQRLDALKQLELAEFETNALEMRSSTEPELEIQNEGQFDGEECRSLQSCPSNVLLPSPILVGMDLLINDLMRKSNNQSLLSLPPNCSLPFHFPFVCLFLFPIPASRLFVANEGVQVIQVKGKFSSFNVYVQGDLEERHVKTVILTVHDVGTNHKSFVHFVGHHTMAGVKEKAIFLHVCMPGQEDNAADFVGEFPTLSLLGEDLVCVLDAVDVRTCIAFGEGAGANIICRFALVWPNRIMGIVLVHCTSTTAGVIEYLKDKLMNLRLENGVMTQGAWDYLVMHKFGSSDKKEKQQYIEELKATMNPKNLSKYLYSFSRRTDFSGIIGEKLDNMDALLVTGSRAPHIQTVYNTHKNMNKKKTTLLVVDGVGDVMVEAPGNLARSLILLCKGCGVLSGVAIPGMERQRTLSSSMEEADRPSRRYSVTHPSNQVTPDIVSLGPKRPLGPKRRGPNGRAQTSGPKRRAQTSCSPHDPCDPTRYIILMEPVEGSLQPILNRDLQILVGEQIFTGVCGCYINDGFLNLFVASPTVRSSLVSVLSKMTVFTLNDRRARISSPTDNRKFVCIDFRNMTGYVYLKHLVQLLMESRGKFFDVLHLISLKGVDVEKLFTIFMMLKDLIVINIPYEFDSFLRIGESKKLDKLIERNAGTLRSVHHLVYPFSLLPEIRNGIVAINSATLRTGSMEREADFFAFYMDKKCCPKELLLPEDGGILMNVSINRCREVLRSVKRAFQRDNIRPKITKFGLSSTYDFDTKSAQILLAQIERIRNTLPNVQSLSIELRTLEFNPNQDRYSADDFPEWEAESDLVPNSASVCSNVALFFVEWLRKQKCGDLRIDGCVRLAVDYHCGKETDNAMLEKALRETIARAVGQNWTKLLEESVTVRNGCASAIAKVGMGDKYSFSFCIEFRSITFCDAPGHFEKNLFRVVNSLDPLPNANAQCPTQFDFRCFHSDDINTNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H253</accession>
    <name>A0A914H253_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="10">PARP</shortName>
            <ecNumber evidence="10">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914H253"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13186.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13186.t2"/>
        <property type="gene ID" value="Gr19_v10_g13186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WGR" evidence="15">
        <location>
            <begin position="618"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="14">
        <location>
            <begin position="750"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="13">
        <location>
            <begin position="869"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="508"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13186.t2"/>
        </source>
    </evidence>
    <sequence length="1108" mass="127610" checksum="47A07D85A552FF35" modified="2023-02-22" version="1">MDNRGMPLLMITGYPSCGKSTICARIFSYFEEHNLGENLYIVSDEGIDSNFSRLIYDDLKKEKEVRSALRAKVQRLLDKKSLVICDSTNHIKGYRYELYCLAKNTQTRFAVIHCKASFSTCKWLNAQREDTGRYSDSILFNLLKRFEAPEQKNRWDSPLFEINIGGESAIKSIEMRDEFGIITEDANDCALAENFGKMSETELPRNVNLPLEQIYATLVKGKELSANKCMKLQIPQILDRLLALQRRATVGDTLTVLDGERGHANGVAFSRIRPLPQLSRLRHQFAMSNFQIVWEYQCSPAKWVEFERGLATFLDGFLNDSGGSGFEFEGRKVIFDLRLMRQCDSEGRVTRNIRCAVRPTGGGAQVKFVWSYQYGPRKRWISFPADLSLKLEEKFGCVSPTKIVRDQKMEFTLNGEKVQIDWRTKKMIILNTKEQCVFRRTESNAQPSNPSDSPFPPNRMRRGKYSLINEEGTAKIKNGRSLYLEKDKEKMGGSEGKVERKVMRKMKVDEVEEEVKRKKEAGEVVEVEVKRKKKAEEVVEVEVKRKKKAEEVVEVEVKRKKVEEEVKRKKKKAEEVEEEVKRKEKAEEIEHLDENESKLNGVQSDVEVDAECRELRATVRVYVDEKGRCYDVMLNQTDIHQNNNKFYLMQLLCDITAKDKIWLWRRWGRVGFRGQSNLIPFGSEFDGALTMFLNKFSDKTRNDFLEGTENFQKVAGKYDLIKIDHDRRKATEKKIGVKLRQNVSPTESKALVMDDRVRALLTTICDLKAMECDARRLEYDFKRIPLGKITKEQLNFGYEALSRIERQIQKANFGREFVEAMNDYYTRIPHSFGMRTPPPIKSPEELNRETELLEMLTGIEITVANIGGDPLECHYARLRWNLIPLEREDENYKIVEEYLRETHGPTHDRYQLKLRNVFEFKPKGTVDGKRAEGIDGTRKEIGVGNRKLLWHGSHLANWYSILAQGLRIAPPEAPSTGFMFGKGVYFADISSKSANYSLCDPDKPGFLLLSDVALGEVLDLKEADSNMHKKLPEGKNSVKGVGRYVPLPNGGRKIDGNVEVPCGKPTQNAELDAEDETSLIYNEFVVYNLDQIRERFLVEVEYIFDFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2A1</accession>
    <name>A0A914H2A1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2A1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12572.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12572.t1"/>
        <property type="gene ID" value="Gr19_v10_g12572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="10">
        <location>
            <begin position="373"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="9">
        <location>
            <begin position="488"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12572.t1"/>
        </source>
    </evidence>
    <sequence length="692" mass="77232" checksum="DE830B3B9836D064" modified="2023-02-22" version="1">MLRLTKVQHQSEALPFTPCNINGEEILALVDTGSEASVIPFSLVTRMSVEKRTVQLKAANIKLKSALLKPEVEVLLKMYIRQMTIGGSSWSISAEILVVKDEEITFHGFQMIMGMDIIKKLGRITMIPGQGRIIFEPNTPLGWQSTDSWSKAESSSHNIFSLAPNTSIVSATLNSLPVKCLIDTGATVTVAPKSLALQLQCKISSSEMHAVSASGHVIDFREKAEAKLEIGGNSSDPMETDPNFKVDCSSQYDLGSFTEGPHHFVTTTEEPVSSPPRRMPYKYRDELKQHIEKLLAAGVMIESDTPWVTPFVMLYMPFGLKNATAAFSRAMAIVLSGLEECAISYVDDVLVFTRNGTFDDHLNLSRQSVKFEWKDEQQKSFEKLKELLTKAPNLVFPNYNQPFHIFTDASLTGLGGVLMQKNESSDGFSAISYCSRTLSAPERRWPAVQIEMCAIIYALREFRPFFFSSDAAQIGRELKAHGLDRFALSATADSMQGHESDLVVVVTTVSQRQTNHQSTRKSRGNAFWGDPARVNVSLSRGKHGLVVIGNLMELTQCKIWDRFLSKALEGTVVATPSFIRASMDEQSHYSRGILVDRDGSVQQDFRFHAEWNSPRSMADTFGEYKGTEQSLNFRSGHTEQRADATTRGEMLDLRSARTWHWTMPRGDQAMRWTEVKFGTNLMEGRTCEAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2W5</accession>
    <name>A0A914H2W5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2W5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13488.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13488.t2"/>
        <property type="gene ID" value="Gr19_v10_g13488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13488.t2"/>
        </source>
    </evidence>
    <sequence length="345" mass="38776" checksum="41AF62450C7ABC52" modified="2023-02-22" version="1">MEMSNPKQNQVNFGQRWQLRADSSVSEHGTKPFLWGQPPNFVTGQNQNNLEEPAASLGTSSSAKIGPITKKDPVADYGRPPWEYSSEEDKEETERTSRKDETERTSRKDETERTSRGPEEWGQESGWDDVQQRQQAGTSAPSGVSPSNPEAAHFAGTSVRCDRSKDNERVQPFFERRRRSATSDKITFRAANSGLTILLPKGHPDLPAAFRIASETYSHGYNVDNASKALNRFIKRNLLSVNKTQCLEVEDRSAWHSLVHVCRKFITVQSIGVKSAKFEGQGPTTKDAVDNCDLAILYELFDFDVIKEANVEINNPQRKLEFDEYGSEAGFKDASLVGLLYKLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H497</accession>
    <name>A0A914H497_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H497"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13507.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13507.t1"/>
        <property type="gene ID" value="Gr19_v10_g13507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13507.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9489" checksum="B1BF5A2890ADBD11" modified="2023-02-22" version="1">MDQFNKQPCLDYHMQSQQFMHDSDSLEDFSGTIIVDRIVQPKREMYGQQPVDMKVTNINWMEWPNVARLTSVANPDNTAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5G4</accession>
    <name>A0A914H5G4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5G4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14344.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14344.t1"/>
        <property type="gene ID" value="Gr19_v10_g14344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037778088" evidence="3">
        <location>
            <begin position="29"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="242"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14344.t1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47883" checksum="C3F7176069225EEE" modified="2023-02-22" version="1">MPTFLFLAAICLLVAYILLLETVPKALARRMKHLLDTGHPADVHFLVVEGDEKEARTCGGVGHGGGAFKAMLAFIYADDLSELNGDNAISVLYAAEKYNLPKLVDSCLNIIWKLMNVFVALAHARFFGEENAQTLLLSEEFLQIDQELLCEILGRDELMIRDEIAIWNAALRWADEKRHQNGKEPSAANRRAMLGSALFKIRFPLIPQKDFTENIVPSGVLTSDQMMSVYQYHSHPNAGLPEPYQLQFPTNRRAFKGLTPTNRWDSAACHQGLTLSEPERLIVQHFGEKGHRSVRAERPIPKDGIFYYEVTILEKGTGICIGLATEQQMALNSDCGDLWRKRRPLGEKPMGETPKFEEGVVIGFGMDLATRQIIYTLNGNRLETTGLFVDSAAKLYPCVTLLNSRTKIKANFGPNFKFNIHADAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5S4</accession>
    <name>A0A914H5S4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5S4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14435.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14435.t1"/>
        <property type="gene ID" value="Gr19_v10_g14435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000211">
        <property type="entry name" value="Polyubiquitin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="334"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14435.t1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46672" checksum="40E86364E459788D" modified="2023-02-22" version="1">MEQLSSKFDLQVQIRERAFMPDTVYIDIDRQQCWTEPIQHLGEYKVLLHPKLDDNNAGLIVGARKIVPEKVGGGRRLDEEDVPMNGQLAEFRDKIGRIENSFALLQQGQVRCVSVEHFSLLQAKIDDLERKQKADQKEHSAKIDETTEAKIATELGLQKLVKEHKALQTKIEEYQNKQQQSIYELSKKLTVSIDQFSLKHLEHEKLLNAHKNLMEDKIDWLNEEQHCASVDQFSLMQGDQKALLQRLNGLEQKQTTNSEQQKADQKALNALVAGQSKKFEEQKETNRMLQKQMNELGNKKELEKAMNQLKGELIAVLNAELPTKNQSSSAVPTMQIFVKDLNGKKITLEVEAENTVADVKEMIEAEMEIPTDQQRLIFNGKQLEVDRTLADCNVQEGSTFTLILCLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7C8</accession>
    <name>A0A914H7C8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Trehalase</fullName>
            <ecNumber evidence="3 5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3 5"/>
    <dbReference type="AlphaFoldDB" id="A0A914H7C8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14881.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14881.t1"/>
        <property type="gene ID" value="Gr19_v10_g14881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14881.t1"/>
        </source>
    </evidence>
    <sequence length="479" mass="54545" checksum="F97AD65D8240479D" modified="2023-02-22" version="1">MKRLSIVVRNCNSVLQLMANSSSKCPIIIASGSFNFDDTKICAIGKANDRKIFDQLLTECAAGPQHLNHHITKSDVQSSAKQQMASPSTGSATSAAAATTANSDDSVPISTDQLILRTRPLPSHSTTERFVNSVQFPISDRLLIEAVYDQRTEKPRAEVLKEHFIKEGRIDEDAALRIINGAHSKMANRSPPIPPRLRELRYWDSYWIVRGLLASGMTSSVRNICKNFAELIDRFGFVPARNRIFYSKRSQPPFLTLMVYDYFGATGDAKFLKEMLPTLEKELDFWRTKRSVEVIVKGKKKTFYQYKADTNMPRPEAFCQDVDLVKNMTDPKEKAKVWRNIASASESGWDFSSRWIRKDEADKKNAWKLNNLMTTRIVPMDLNALMAYHGKYQPLNEAFYGSAAMPLFVRFYDTIDLGTAERMFHRLELFHKQHKLLGHPFGVPVSITVNSSQQWDFPNILPPSQHMLIEGLRRSSNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H871</accession>
    <name>A0A914H871_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H871"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14711.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14711.t1"/>
        <property type="gene ID" value="Gr19_v10_g14711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037871034" evidence="2">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14711.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14747" checksum="7527AD93045690EC" modified="2023-02-22" version="1">MHLLSVIVQLLLLVLALCRCCNSTSNDGMPTEGTENQPPNESKSVSSPSAIFVGPKFSHLASRTASKTVMLYDKPNSVDDAQRYSVLNSDKWWPKPSSSNIAVNDPVTAPRTTITYNMPTEKAKNLQKLKEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8R2</accession>
    <name>A0A914H8R2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8R2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14795.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14795.t1"/>
        <property type="gene ID" value="Gr19_v10_g14795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14795.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16264" checksum="13538572A50255B8" modified="2023-02-22" version="1">MWPNSRQFHSSHRHFHGTLLTKRLRCIKHCKCCTFASHATTSSDGRVQRRGDTDNHLRQLVNIVKDAHEKGIKQPNTLLIMRADYMVNTLNNEVNTGAIGGLGIDRRTTELHRQMLQKVGMDTSNLPANNGDTNLIKSLFMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8Y8</accession>
    <name>A0A914H8Y8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14867.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14867.t1"/>
        <property type="gene ID" value="Gr19_v10_g14867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="569"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="916"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14867.t1"/>
        </source>
    </evidence>
    <sequence length="1352" mass="154266" checksum="A076FE5BA55F9CEF" modified="2023-02-22" version="1">MSKRFTDFSTESILTKKPRQGFLINQILGIAHMLGSAQTGDGASTSSTTRKTVAKDYVKKLDSSLEHIPKFNYVKLKSAFSIQDVPSDPEGLLADIFQFCIDEAVADSRERGMQPTHLGCMISSELLTGGDIPVPVRQITDNTIDTILNLFNKVAQSKQQNNVTLWGEPFTVTITTVDRTGLPSKRRVRGGARRKLAAVHHRIHDQCLIKIRNERDSYCLFYALQATMVAKTRSWPRWKFFEYLNNRHGQQGQLQQETRQLMEQLRVPLNMEAYDADTYVPRVIDHWNNTQQQHRFAVFIFGSTGQYKPLFKYVDNTYDTPLLLYFNNDHFDGVQKQGGLFGQPYCLECERPYGRASKHNKTCKARCMLCSRTGPAFPCASSAGFFRHCAACNKNLRNDDCYQHHLRSNFCRRSKKCKDCGVIWDVPNNTQNGRAGHKCGEKFCALCNNYHNTERGCFIQQLEPKENDPYRIVAFDLETMQHLPVDAHPNHRNHEPNFVSAKIACPDCISSGKWRQPLTDGASCTVCGKHRTIAFCQRRFADTPIDKQVVTDNPLEAFVDWLVNELPTKYDTYAYSHFGGRFDMVITFRELFKIGFNPEMLRRGNKMYEMKIRKQKGRNPNIIFRDSFNLMPCSLAALVPSYGLDVEEKPFFPHLANCPNNYGQKIFPTPDDYLASGMMPEKRRQFDHWYEQHRHEPFHLDEALASYCSNDVDILMAALIAFRREFFEISERHEYVDGLDDRQNHDGIDVLKECMTIAAACMRHFRTNHLPSDHLAIVPERGYDNAQNQSRLALRFFHWYAVEHGVQLQTAHSPGGEKRVANYSLDGWIEAEQRGIEVNGCVWHGCASCYPDDNQLLPSGKTAGALRERDSKRLEFLRSQVPRVDVFWECEIRRMLEGDREMRQIFADYVNDGPLEIRAAFTGGRTGPLKLFHQAGEGEKISYFDFTSLYPYINFVTRYPIGHPIVHVLNEDVAWTTPSDNPYPLALLKVLVVPPRHCDVPVLPVKVDDRLCFPLCMKCAKYYPNGGADDNYRCDHNDQERGWVSTCTSLELNAALEAGYRVNKVVRVLEYQQSDDNLFKSYIAEFMSKKIEASGFSADIKGNAELEAAFVRECNEMFGITVDSAKMVPNKGKRSIAKLCLNNLWGRFSLRNFGLSQTLITDDPVVLGQYLDNKSIDVTSIDELDEEHILISYMQKEEWVEEHACSNISNHFVMDYFGGSPTAAQGYAKSGACAWVYSTLHRGGAKQYGLKLKRNGAEEAELEYVLKIRGMTLNFDVMVNQGLRYNTFKDAVLRYAATGEVERIQVIYPNFLRPSIKDARVTSAPLQKCYKPYVGKGVVGADFNVLNFGHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA63</accession>
    <name>A0A914HA63_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HA63"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15470.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15470.t1"/>
        <property type="gene ID" value="Gr19_v10_g15470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF42">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00698">
        <property type="entry name" value="TMPROTEINSRG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15470.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38460" checksum="E1F66170C4E0EF75" modified="2023-02-22" version="1">MGILEWSISARDPLIYFAMCLSIPSMALYIAEIVTILRHKQFHKSFYSLFIIRAIPDVLYVLNSFYGYRLPILFGSVLYPVYSLLPKWMINLDFFLTGYTLQANSLATAFILLNRLTAISVPLKHEKLWRKFLPLVAIIVFCMPICTNWVMFKSEGIIQKGNPNSTDQSLFLYEAGEAPFLNYLNYMDAASSVIFMSVCILINIAALTAYKWQKKKCVLNPDSSDQLERKLFIYALATFSGHALIACLFIGIYIATNSQNMPMAMAMYAHYPWVLDTGCVVISSWLLLWAGDSFRQQLMKDYRIPRIRCESRANNRVDSINVSNTNNCWANRVINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAX7</accession>
    <name>A0A914HAX7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAX7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15413.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15413.t1"/>
        <property type="gene ID" value="Gr19_v10_g15413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037366299" evidence="1">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15413.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="51589" checksum="17F5B31E7B333B16" modified="2023-02-22" version="1">MFAVHFALLMALTFWPIITPAQLLVPSAADLLLKLANNGECALIGDGDGTDSECATTASSLASRPPPLILVHGFVANKMYLDGQNTPFPTNLPPLCKIVFASKYSVKGWINPLLGAGNVASVTLTNLQSCLFYLMSLRYDNTTDTYHNQTGVGVTMLARRQFGLTCPSTCWISDSLPGGCALSSASPEPVDEVYFAPLINNCLAKFGYVKGCNLFAAPYDWRLTPGMAVMDAYFSNLTNLIEKSVNTTGKKAFLLCHSMGNLMVNYYLNQRMGQEWQQRYLNATINVSAPWGGATFIIEQILSGNVDRLFSGLSLLVSNLEVRKFIRTFASVAFLLPNLLAFPLDTKLASISGTDYTLADLANLLAVANIPYMEQLYQNLSPQIDAQKYTPMFCVHSNINGSTVKAFDYPSGINNAANASMGDGDGLVNIESMRVCQQWKGQGKLVSQVTEFSGPTHAGILRSTSFCELVKTIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAY5</accession>
    <name>A0A914HAY5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAY5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15419.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15419.t1"/>
        <property type="gene ID" value="Gr19_v10_g15419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15419.t1"/>
        </source>
    </evidence>
    <sequence length="395" mass="45081" checksum="58C997A7DBB5000B" modified="2023-02-22" version="1">MSDNPAKEEKQRKENFIYADLLFEVFKFCGPFVSGLKVALISDRFDLLVDAHFNSKQWSLGDLAIQRAIEGNGAEIVKYVGDQVERQLPIPQEPFPDKVIGFECFSISYIDQSVIEFLKLIRPLFASKGADLTIGTSTDQNRSWRIICYQIWPLIKDNICGFNLAASNLDRLLQFSSTVLCDCQKLRVIDSFNLFPAFSADDSAGASSGQALTKWLHMPRGDGLPKVLECRFRLTDIEGLKLEFVNSTDPVNFIIGFRIWSSNVIVPFELKNNLTGERLELRHFDEGKWLLVRCPIERNKKKWRKWEKEAIEWNWGSQRNHIIIDFKDGDIGDNFGDKDIGDGTPDLSMGRCEQKINVLLSKCEAEIQIASGLEPTPPSYTTHHYTRRSLLFSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCC1</accession>
    <name>A0A914HCC1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g15799.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15799.t1"/>
        <property type="gene ID" value="Gr19_v10_g15799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548168" evidence="10">
        <location>
            <begin position="16"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="67"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="157"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="277"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="517"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="639"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="749"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15799.t1"/>
        </source>
    </evidence>
    <sequence length="1373" mass="150636" checksum="21C03481EBE82DCA" modified="2023-02-22" version="1">MLLLLFFLHLPSCSAHQPSTPYAEQSLHVQLVEECPLGSPVLRLPPLPPSFSPWHLSASPHSQLVPFNVSSGTLLVAGRIDRESLPVDANNGKCLLHFVFVSRAIGSSQLASSTSRPTTLAASSSSLNASTKPSPSFRLLRLTVEVLDVNDNAPTFGADPLTLSISESASPGSRFSLGRARDADAGDNGTIGGCELLLLPVGASLTENEDISALFRAERGPAGDFVLELQDGQLDRERAAQLHGQMKVWDIGTPRMEAIVELYIRLLDANDNAPCFERALYTVTFDSNYKMSSDKVSVGKVSATDADEGVNGRVRYELSERTGAIEVDERTGELFINRRRPESVCPPKGNCTFVVNAIDGGMPPLSAKATVVVQFAKSVGTEVASNETGEKKRPGRRDDRPQGGIRIKNLPSGLPFASLNANTPNGTVVSVVTMENVGEEETIDFGFKGSEGLFRLEQIRNGLALLRLNGTVENVGNGRPWTVEIAGKRSDGRQIGPSEKVQIFLRHASDGPAPLPLPALQTVRLPEDLPVGSLIARLNASSSAPSSPYSPTFTFRLASPEWEELIEVHPVAGLLRLRQRLPPLREGEAMRQLTVKVELARDPPAPSAEENAAQAEVLIEVFDVNDHFPLIAGCPPKSLPCVLSVHLLEDQPLWTPFLTVNATDPDSGPNALLSFALRPFGADLNSVSLFAIDVQRGNISLSRSFDFEQWQEHRLWVEVKDGGTPSRKVKALLEVFVEDVNDKVPQFASPEATFLSLRLSQPAHSVLLSVLASDSDPDDRALGLRYSILERGSGTSPLGMFQMADGHLILAKSPAAIGLHANDHFMLQIGAMDCANHSAPSPLNVHVRIVSDLAKVPPKMVAILRPPLEEGNCWTEGDILKALAFPPGDDGPRVANLTLFRGEPSELIIRSKPISLCLRTSSSTTALSSSRSVSHFVLADLGLDGWTLIKIMRRPIPSDDLPRLIFLNAAPNITVTFPEMAIGTPLHRFRLKVIGSSSCQIRFRLEGDRWDGVLGLHPTEGLLWLARHVGWADSKDGTEVRAVAQLADGKAAAEQKFWLRIERKAFDEGAENFFHFPPSLTLFVPDEPPPRPGDLLANLARFSPLPYPCKLRFVLQMSENWWPNSSSNWAATELITLLPDGEIRLLKEPPFGLTIWEREVKAAQQPFGGPPIEERVVRMRLLIRRRSLRPAHFPLQCPDTPKTFRWPSNAPSGTLLGILEHNFAGGAEHIKRFQLLNLLELFIVDELNGKLRIRSTEVGTDRGRHLDLRYRISEVGRPAGKLVECSAKVELLEESVRGEEGIGQRRIVRRELSQREASKQLQAGMEIAEMEQFLQNETTLVMRDLLGSGQQFQVRLQFHLWDISKGLNVYSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCF2</accession>
    <name>A0A914HCF2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCF2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15766.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15766.t1"/>
        <property type="gene ID" value="Gr19_v10_g15766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF13">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15766.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28882" checksum="4EE039A21C102896" modified="2023-02-22" version="1">MVKHNTRVRQIGQVRIGFGDAEPLWDSENEKYKVLCRSIHVSKASLYIGYVRLLVSFVSCIFFAYQYMMAVTGQMSADNWINQMTARFMSKAMLAICLQVIVVVLMIHGVKTEKKSMLLPFIVYSGIAVLASSIKIMSDLVYLDMSIYKNDQVESRAAKIQFVSDLMRMVLQAWCLSVVWRCYGYLTEKKVARQIREQLISTATAFNYPENLVGHSMMPQQPPPYASVVPAPIVIGPPSDKPQPSPKNTSPTAASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HED9</accession>
    <name>A0A914HED9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Titin-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HED9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16586.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16586.t1"/>
        <property type="gene ID" value="Gr19_v10_g16586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16586.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16552" checksum="8610E035CF1A6FA5" modified="2023-02-22" version="1">MKKIPEPPERMGPEERQTVEAGRVTNLKKPGETKTEMILAPEKMEMKKRPERMEPEERQTEEAGRVTNLKKPEETKTEMILVPEKMEMKKRPEPPERMEPEERQTEEAGRVTNLKKPEEIKTEMVLGPEKMETKKRPETSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGX7</accession>
    <name>A0A914HGX7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The selectivity filter, in which calcium ions are arranged in single file, is composed of two acidic rings separated by one helical turn along the central axis of the channel pore.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGX7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17396.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17396.t1"/>
        <property type="gene ID" value="Gr19_v10_g17396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 15" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="16">
        <location>
            <begin position="100"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17396.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="41143" checksum="EB77EACD58FCEED7" modified="2023-02-22" version="1">MFSKTDNLFKNTRIFAHLLYSKNIPVRFAKYATQPDDLKNSPKTPKLGHMRPLVDGKEICIENGLPVINIELPSRKETCQFILRPMGDSVGSLSEALLNEDSGIEIVSFYTSDGTRISKSTRIQHLLRLPSFCIRINDIYYRFNLQSFAFEDRDKLTTLEEIKSQIFSLYGFLNLDEYKLKRENSLMESIENVERELRPFIIIKSTIERECEEYTQRVFWVGFSAVCFQVGVFARLTWWEYSWDIMEPITYFSTFSSVLIALSYYIVTQQNFEYTSAHSRVLYNDYYRRALKYGFDVKRYNELHKLKSELTTELKRLQNPLLAVFDGQIGLSGDKLSKCNVFASNEHSFSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGY2</accession>
    <name>A0A914HGY2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="AlphaFoldDB" id="A0A914HGY2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g174.t1">
        <property type="protein sequence ID" value="Gr19_v10_g174.t1"/>
        <property type="gene ID" value="Gr19_v10_g174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036409">
        <property type="term" value="C:histone H3-K14 acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0853">WD repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="240"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="14">
        <location>
            <begin position="526"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="705"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g174.t1"/>
        </source>
    </evidence>
    <sequence length="947" mass="107449" checksum="D00B06F0D6BF10A5" modified="2023-02-22" version="1">MVKTRSKLIKLRARSVGPNISLSPRKTRAIKRKEWDDSDCENRYKRCVQCQNYQPVEELRQCPGCCSTFHLRCMALEPQTIRCNNAPASNSQSTVTWRCPRCICCARCIELVADPANVQCLHCARAWHGACRPETSEPALYPYKRWTCGACKGSSEAISTLTEQRVAPGAGTQKRGGRRILKISVEGMDTHWTGKRRCYGDGAADGGQQQQRVQAESRISLVKQVCNKLNELGFTPAKDIRNSSNRWLQFGQFIRFQPLYESAYQEPIRSAKIIYVCEFCLAHMVDIDKFRSHVMFCQWRYPPGNEIYRNVQERWNIWEVEGNTETAYCRNLCLMAKLFLSSKTMYHEVETFTFYLLTEITSRGCVLVGYFSKEKNPSKNNNLSCLLTLPNTRNRGYGKLLIDLSYQLSKLEHKIGHPEHPLSDMGLMAYRSYWRSVLFCALRQRCKSAEVSIKDLSIETAIHSYDIVTTLSANDMLLFRNDSYYIDNTKALNANLASLRRRHICLDQLRWRPPFEVYPHSSKMNSMILDELPAELLPSVYRHIPGDFLWTNVRPVCRRLNNSIRRNEYWLRRLNIFYGLQLTPRLRVAPPYAASEAVPAEQQHQHLAEEGPANLMPSLRCVATERRAASLPFAHRQDEEAHIATIDALRLFSDSAAGDASPDRVLCLSGARDRQIVLRACNARRNLSSSTHNEPAAIEEIARIDNAHNGWIWCISVVPDGQQFYSAGWDSRIQQWNIAESRIERGLRLDCNSLAALCCVTEGQNVLYASTYRRGPILYDFRVGTQPQHELNMHGNSPVIELATGSDCNQLFSIGDDNRLVSLDKRQFSTLLGEHHAPVSHIDYADGQLCLSLKTGQLRFFDPTTLALENELAIAGTGQGPYHVIRLTRGATFCVTSDFMLRMYTPGLRPRLIASTELDASVTRLDVLNGTVVAALSTGVLAYYFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH34</accession>
    <name>A0A914HH34_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TBC1 domain family member 9</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH34"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16561.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16561.t1"/>
        <property type="gene ID" value="Gr19_v10_g16561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF6">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="205"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="926"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16561.t1"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113758" checksum="AB36DDBCD4BD002C" modified="2023-02-22" version="1">MKTKRKIRSLVFAGCRFSLPHDERLDGDVTCRLYTPYDKRCVLGQLHLSANFVCFASRTERLVSVVILLRDIVMVEGHKNFEEGITNAIRIQLNKEQENREFIFSAIADQTKVLQRITLFWQNCLRVEKQIKSSLVQHSHSGGGRRLARKILHEPLHAHYPHPQASASACTHLRTARRWEKMFRDYGRGYSMYRTIELHRLLLEGIPFEQKAHVWGICSGALVEMRLNEGEYTALLRRSRHNTTFSELTMDEIERDLHRSLPEHPAFQSAAGIDALRRILTAYAVRNPTIGYCQAMNIISSVLLLYAPEELAFWLLVAVCERLLPDYYNTKVVGALVDQGVFSDLVGQTLPQLHSKLIQLGLDDMVALSWFLTIFTSTIKFEAAIRVIDLFFHEGSKLIFQLALEMLRENEELIVKARDEGEALVALNEFTDKITDSNVKNSTQIFVGDLISNSYKHFADTFTNDTIERLRLKHRLKVVQNLEDSQMKSIVKSVGRECRLRSDELCCLYNVVRQEHLLTWRSRLNTTTAQHKKTSTEERKMGGRAGVERPRIDSCLQSQYRLDFELFAQILSRFLPWQPADEIFYVRAFRLLDMNETGILTFRDLSCFLGTLLRGDPTEKLTLLYRCHIPPAFNMSDLDELIKESLSFGGAELGVEAADVFGSKGASPERSKFSPRPPLDNDELELPQGSSTSTVSLSSSTLLMQSVSDSTIGKFDGASSINSSNVAFTRSPSAGALDPIETGSLKSSTTEAQSEFSDFSILNNNTNSDNNKHLQARFAQRQRLLDSEPEGRLPSVLSSTSPVASIFGTMPGAQTLEQITQVQFIQFWKTFYDMAGSISGTLSSSLETMESNSANGTNEDECETAMPAEEEDAQLFHALSYVGTLLLQLGEAHRSRREEVERQIVEALGEEAKALIVLSQDDAYIGNNNGEEQPRPTSSISTSSKAGDLNSCINDAEWRLSLGQIVATVLANATLAQIFERSYPLKQRQRRSATDATTAQEGKYISSSLPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHM0</accession>
    <name>A0A914HHM0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHM0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16704.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16704.t1"/>
        <property type="gene ID" value="Gr19_v10_g16704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF97">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="395"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1037"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16704.t1"/>
        </source>
    </evidence>
    <sequence length="1179" mass="131833" checksum="AF568F77E82DF6F4" modified="2023-02-22" version="1">MSATDRAPPSPPAPPAQKESVDSSAVTMRHRSSAAGRQSSLIGFPERRRSSILVGQRSMDLQMEQTGNVGPRFVLFVIRAFRRWGYFVADYDWQAMLVCLLTSLIGFIIVLRTPQQNDIQGYAPPNARARIEYSRYQEFFSRDGPGISVYIFIIAKDGGSLLREDYLNETIKVLDIANDEVQLSDPEMGTNGSQSFSKFCLSFCKANDPLRAFYHGLNYQNTLATKGQKLNGRINLDYPIARIFGRPMSLQQTFFGVEFFNESTASGVDPSDQRQFNLTDALLRAAQSDDETADIDDEKIGDNSTKSLAELAASGQHQQYVTNMREMKMVMLRFDAEHKQGWTSDIVKQYELTMRNRFEKKYESKRLAMYVLSKSVIEDEMIRAGLSIIPYMSIGFAVMVICSVISVLIRALYMHQQSAPKIFLAIAACVLPFMSSATALGFMFLFGFRFASILCLIPILVLSIGVDSSYLMIHEWQRVIQHSRRQPNRRNCHVGYRISQVLSEIGPAVLISTLTNIFADGCGWYTSSPELGGLCLGNLVSMMVAFFYQMTFYAGLMSLVGRYEIATEKRERRELQESIRRAVETSGAGMELGMSSVKHGLTRKQSKFHEHTKHYISETIQVYVNFVANKFVAMLIVTFYFVYLGLSIWGVTRMEVKLSIQQLFTMDSPLLMVDKLRVGYQVPHFMSVTVLVFNPGNLSNPERLARMNQFVADMEAINGSWGPIGTKYFVRDFIAFQLSNEADLDTELAAIDAGELEKSAEDRTALATTTQTPNGPFHEEDIGTFMNWPESAEWKAYIRFDNKTGHLQRFFFTTGYHGEKLRIWTERGHILNQWRAVVDKYANPDDFNASLYYDDSIFLDLIDNMPFDTMQSVVGTLFCMGIVCFLFLNSMFTVAMASGCVLSICCGILGILSWMHTDLDPITMAAMTISIGFSVDIPAHVSYHYYQAAAQGVDLTPQTKLVNCLSSVAFPALQAALSTCLCVSSLLLVHLHMANVFVRTMVLCVLLCNLHGLVFLPAFLILFDSIVQHVQQRVRTHRSNGRVAADDGKRKRPTPIPEASGSQESSLRQMTKLPEAVASKAMLQQQQQQRNGGGGNGGHYRNGARVGKAPAEQSNVTDRPVLDRFNSVDESEGTEMAPKRSLKSMVNIPSTEEEAEEGTDAAQKAAATATAHNGGERKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI04</accession>
    <name>A0A914HI04_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TGF-beta family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HI04"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17545.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17545.t1"/>
        <property type="gene ID" value="Gr19_v10_g17545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13761">
        <property type="entry name" value="TGF_beta_BMP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF310">
        <property type="entry name" value="PROTEIN 60A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="10">
        <location>
            <begin position="292"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17545.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46583" checksum="34D504E6731206F6" modified="2023-02-22" version="1">MCSWWFCSVSNLGPRKPRKTARHGKVLKKNANKKWKLTTTASAALFVIFMQKVATLSSESPIQSTTTKMTTISPPNTIKWSPDERLLLRQAFLRKFGLGTLSTAIDKSSTERQKVPLYIWKLYEKHRANPETETIRHYASSAHVQEDGVVWVTFNLSATGRDPEKEQIVRAELHLPRGQEANGTVHKVTELRETPVGRGIERDGRASLDVSLLLRGHQTERFTLAWSLPQGMGPLGPEHLENIALIVFTNSDKYERPAWTSQNKVKRRAKRWLSQRTNSASKSNDASGNSSRQRKHRTHRKVGGEGGSQHQCRRTELYVDFGELNWHDWIMAPSGYEAYQCRGRCTHPLPAMLNTTNHAIVQSLIHSIDPLTVPAPSCVPVQMSAISILYKDVNNVIVVKTYADMRVDACGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIM6</accession>
    <name>A0A914HIM6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIM6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1806.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1806.t1"/>
        <property type="gene ID" value="Gr19_v10_g1806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="744"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="850"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="951"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="954"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1806.t1"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113273" checksum="02BE27B9559FE733" modified="2023-02-22" version="1">MSAPIQQKLGAALRILARTRTAAELNLLADNNAEHLENALNFETQLEKVQKEARTLEIFLDDIREASSAWADLLRKLTAAERDAAEDKFSAFNTKEKINDKADEASVKLRNLRDLISTLTVQARLYRNRADKEEREAQANHQRALQQAMQPNVAAHQAVQTQQYATPFYQFQPLQLEKFSGTKRRWPEFYESYKSAVAGHPIGKAEKFNILRNLLSGEARDLVAGFRLEDQNYDVALQLLKDTYGAPEEHIRALHFELANLKSCKNLRDTKEFLLQLERLTRELNNAGEDIEGPPTFLMLEKKLPPSFLRTILTKKGENPTHWTTTKLREVLNDAVRRESQIQEVMGEYGHHQPQTRPLPPITAGSELRHNNQLAHPKDHTFIQSSVDNIHKRLLTSPHTNYPNQPIPQLARAVPPTTQQHNRPPFRQPQEYNQSKPPSSCAFCGNNHWHEECRKFSTFEQRNAVVWEKRLCFKCLKANHRASDCPSPKNCFKCRQLHPTALCRNGGHGSTKSTTAIDPINSRRGSESANDTRADVMPLNGIRTEGLSQQCNATSDNEIKAVLMTTTSTVFNPAQPHRNMNATVFIDPGSHRSFITKRAAKQLNLPVVITEECHLTSFGARKSKKYVSDLVKLGFQGGGGQRHIFNLNALEFLVNDMPVIQLNKLDKAQLQRTTLAPPHLEKQPDIMLGMDVWHELQVRPIERLPSGFMLCDSTIGKILSGSGRIEMTEASNITFVGPVHAQAARKKPTCNQPTKKHSNKEKTTRKSVQKKQHPIRLNSNSTTNVAPNATVSGDEQRRKEMEKALLRQHQRNKLFSNTARLRTTVTHLAAAQATNPPLIDLTSDISNSKMEYKSNSSDGELIDPEKTEPISPARKPSASQPTRQRNPKVKQTLGLLLIISLIGLMAIHPIAMDTTNSLAEFNNTSATYEPCETVANIFSTWPALTQLFLRPRNAHTNPRQTITSPSATDRSPRRESVQRPRGRANVSNTWESPFGRSRPLRLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJN1</accession>
    <name>A0A914HJN1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJN1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1929.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1929.t1"/>
        <property type="gene ID" value="Gr19_v10_g1929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1929.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21729" checksum="3E3182A7D7907295" modified="2023-02-22" version="1">MSISNCNKLLNEVEHSGREGNKKYLESLVSKTSSIAKGIRTEFNTFIFEVQLELIKKAKWTSGNKKELANKFSNLYALAQQIESYCNPESFSRAFLWVSGMGGPPCQPGTPEFVEYLGILILNAKLGILKRELHAKIAGFVEHQHFDWNGFMEFSHNFKLEWNQIEQQIDQVNNRDLASTMASFFTLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJU8</accession>
    <name>A0A914HJU8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJU8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1729.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1729.t1"/>
        <property type="gene ID" value="Gr19_v10_g1729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1729.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12852" checksum="8D08DE9F2854AA90" modified="2023-02-22" version="1">MFILFVKVYKIAILLVLKLMRTRCVMTYYAYAVTGISIKLRVTRDGTQRPVTSSSADEDASLLPYQLQRSSQQGLSASRRRPMPPRGARGPCSHSACFSSSTSNFALKSAVEMRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK91</accession>
    <name>A0A914HK91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2100.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2100.t1"/>
        <property type="gene ID" value="Gr19_v10_g2100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF38">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037668123" evidence="3">
        <location>
            <begin position="17"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2100.t1"/>
        </source>
    </evidence>
    <sequence length="730" mass="83789" checksum="33931A079409C1AE" modified="2023-02-22" version="1">MKALLLLIVMFNVMSAHIYHNNEENTNKFTIEKIVLQKGFAQMLLAKASAALKVVPESEQKLFLQCARNGDTSQSVAKCIVKLFEARDNAIKKKSVLSESDYCQNNNAEQGIIPSTIEWLKQILIDPLSKLAKPSTKHTEILRESKEGKKEKHRLNKLELTYKQYQRKMTRRKRRQIVKMKTHYAKLTKLQSKKMSNLEKIERIRSFQEKYKHYSENMAKYNEMRKSITEAYQLRKANFRQNRLKKHINNGTKTPDDDKSTKSEKPLQSKNNARYFSPRIFSLMAAKNNLHYANDSVSFMSPELLRLYEDDDDKKSEENIKKKMDNLNFNNQTFEELLSSVPNLLRLLTPDKLKRRKFLENILESLNVGQILDQILEPVNLMTDTLDKGLLNTSRILKESVESLTQLQNSMTREQFKYYLDKGYTFLSEKQMDIVKTGKVERGIKRHVRSKLGGTKFKVAADHMEDEIEQYIRERANNLPMSDKKSFKTEQMSEENMPKIRQKRTLPISGPIYGVLSPFAFVPQVGSLQLYTLYVLSPQAFIPSYSNPAAFYMQLLSPWAFLANLFSPQFFTCLCLSPTIFEANLMSIPAIAVELLSPTTFQANLLNPAMIDGLILSPQTLIADLLSPQMIQPKILSPQTYSASLLSPAIASPSYFSDNAYGFMVKDSVYLFSPEIMGGHDESEFETEGDNVFYWPKTNEPHEEAYVGENSAHPDTDAHIHPNIVHPSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK97</accession>
    <name>A0A914HK97_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1106 effector family protein variant</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK97"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2104.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2104.t2"/>
        <property type="gene ID" value="Gr19_v10_g2104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037597999" evidence="2">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2104.t2"/>
        </source>
    </evidence>
    <sequence length="164" mass="17308" checksum="08772E842A6C6F54" modified="2023-02-22" version="1">MRVILFLAVVCLVLAALLETANSKPADKKAKKEAASTPAKEKASPKAATPAKGKAAKDTKSPTKKDSKPKKATPKTIKAAEPKPESSVPGPSSAPVVAERDVGEASVNDFDTVDDFGAEDNEFDEDNDLAEEEEPLNDDAFDGTADDFSGMGLDQDKPKSNMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKA1</accession>
    <name>A0A914HKA1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKA1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2109.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2109.t1"/>
        <property type="gene ID" value="Gr19_v10_g2109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036718936" evidence="2">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2109.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="33334" checksum="35FAB94F7FA3F2C5" modified="2023-02-22" version="1">MRTILFLAVLCLITASILETGATPETSPKKTNASSKTGPASPGKPGPPSPGKHGPPSHDKTGPPSPGKHGPPSHDKTGPPSPGKHGPPSHDKTGPPSPGKHGPPSHDKTGPPSPGKPGPPSHGKTGPPSDGKTGPPSPGKHGPAAGTVKLVNSPSMKLSTAQAKKSPSKSDPKSPSTKSPIKRIDEHHSSAQATPPNSPDNKSEQLDNEPEEELENPGLVMKVDKSESAPKSSNSPLLVDNDDDDDDDDDDSMEDHGIKLAEAPKSLLDDDNDDDGDKDGMDGDVDSASNESGSKTATMRDNNEVSKEDPFGADDALKEPVVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLD7</accession>
    <name>A0A914HLD7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2569.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2569.t2"/>
        <property type="gene ID" value="Gr19_v10_g2569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2569.t2"/>
        </source>
    </evidence>
    <sequence length="271" mass="30244" checksum="9D387A67EFBA28F1" modified="2023-02-22" version="1">MLLILLFFIHSTAALSIRQTFDDTSENVENNFKLEGDRFELIEGKGWVENPRKVAEWARAKVCNLNGGETAPLRKLVNVICSAGDHWRYVVKKDFGGKTGLIQIVTNSGQKILQKLHREEAKATEAEKMIITKALRGSMKKVSEKMPEGLGLEAFYASNKQNSQYFLGSDILGAVINKLWPAMIEQLLIKSKVEQIGEYEKFVVKHPKMLAVRKKRQMDTIILMIALLIGGTLGLGLIAHAIAMIVQLFLSKAIVICCVVAIIVIILLQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLG1</accession>
    <name>A0A914HLG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2221.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2221.t1"/>
        <property type="gene ID" value="Gr19_v10_g2221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2221.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20921" checksum="7B1FB259D694CC99" modified="2023-02-22" version="1">MHKTQGEEVANFWSLESLGINDRPEQDDDQLALVMFKKDIHIDPQGRFEVSWPWKLPGEFPPDNFNLAFSRLNSQLRKLKENPEHFESCLTILNEQLEKGIIEPANRTGLPEHFLPHHLVFGKKLRMVFDASSGVKGGKSLNDLLLAGSNLMPELAGTLLQFRSTNFPFYPPPHQKRHVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLH9</accession>
    <name>A0A914HLH9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLH9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2602.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2602.t1"/>
        <property type="gene ID" value="Gr19_v10_g2602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF100">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2602.t1"/>
        </source>
    </evidence>
    <sequence length="470" mass="51564" checksum="00077362779A5782" modified="2023-02-22" version="1">MTMNSPIQQNISDSIAPEDSGQEYHLIVLPFIVLFGLGGNSVSLVAIFHSRLRTMAANQYLIVLTIADSVFLFGIILMLFKVDYVGYVPCVLVEYLLMTASYVSSWSIAALTLERYLAIANPLKHVQYGHMSRWKLMLFWVPLPFILNLVQFITLKPSQTNERKCGISDGGRLQLITEFADVLLCYLFPCCVVVVLNTVIASKKSYCALTTSASTGSTSVAAAAAGAPPHSQHPLSPQASVKASACKSPCGADEQQSSVVRKLSTRTATGNVPVGARTAGGAASGSTSGATRILLVVPVVYILLNTPFYMFRILDTVALNVFNSTMFQHDGLIRNPVLAWCYNVAHYLYYVNFACDVIVYAFSSVNFRRTVVIVWQRIVCARWSHEKDTQQQLHDHRCNTSTLAYQASTRRLLPNTTPGGSNLHLQQHAGHVSACVAPPESRPGSGQCISLEILVAYWMFESLGLPKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLP8</accession>
    <name>A0A914HLP8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2652.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2652.t2"/>
        <property type="gene ID" value="Gr19_v10_g2652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000023">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF495">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="811"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="887"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="1262"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1448"/>
            <end position="1470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2652.t2"/>
        </source>
    </evidence>
    <sequence length="1508" mass="169749" checksum="AB873CE9E4EB67D0" modified="2023-02-22" version="1">MKNLTKNESSLEEVKIRVIYQADNVPGHAFIVVGDYEYDFMTAGARRRIFRFDIANKLEENDKERPQAFKGLGLFVCPLKVEQSFFKMGSRFWFKESFSPSKANCLDFVFNFVCALFDGDCPKKEIWPDNFVNFDKDMFRDYLKLGDRRQPASALERKPISLPANDDHNCVLKDHHLEFRITNFKCDVNDEGGICANFVLSHFTGLFDLPVLLGKELKNKILVETKPKKVWKDGENIHLVAVLKAYSCKILGNLSMSSVGHLILLNKTTKKFIKTKNVCHSHFFGLINLDEIIGHIVEKLQSKIQKTRLYTQMFSNIFLFGITCIGGCLLIKAQQTMPGNSMLAFTTSATPLANQTVIKVAMLIAQNDTDYGLARKNSALRNSGGAIPMALEQLWADEILPQNVNFSFQWHYSNCNEANALGQSYQYIRDFGADAIIASCMDVPPMLGHLAANFNIPMMVWGQSMASALASSNNVTYPSLLNIVPNYKYMASGLVSLLQYFNWTQFAVVTQSDIGAVSGGCDFLGSDIDIALSAQSVVNVNYKARIFDIKTSDTNTIISALQQRARIVLLCFDDIKQLRTFALSLFDGGLTKDYVYIIPDNDLNLSFNLSKLPFWVQSWRDEDAKVIGRLAFWWHYDITLSALSNRNYYGFYERVVKRTRDWPFYCPESDCGSVTNGSLNSILLYDAIYNYGMALNESFKQFGVRPEIYRNGSLLAVNNRKPFMGLTGYVTVETDQNTRVFVLSRRNSDAKGNSLEVLMQLAWVNGQLNVTMRNASSPMWASRAGIIPPAVPTCGFDGKGCTVSVFDMYKGYFVTGIVLFVLLIGGSIFIFAGLIRAKIVQNRRSNLHWQIPFALLKRSKQKHFERETERSRHSLRSNQTNISSLTHATMDSLAQSKIFALYTFNGDKCIVRTYGLKSLAPPLSVAELAECRNMRLFDHENVNRFLGLCLDGPNVLAVWNFCARGSIRDVILSENAMVKDVVFIQSAIKELCEGCNRMPKEVWNAGSGIWHAVLLHFWGQGGMYFLHNSALQFHGRLKSSACLINERWQKTQTKDLLWLSPEQLREMGDFDENVDGSKQSDVYTLALIFTEMVNMSPCWENGGAAEEEGEQAVHLSGEPRRGRSTVTRARNAEEIAYLVKRGGLFPLRPSLRPAFDNLNPELIHLIRDCWVEAPNERPTIEKVRQKLRQMNAGHSVNLMDYVFGMLEQYANKLEEEVQERTRELEGEKRKSDILLYRMMPRQVADRLKLGQSVEPEHFEAVTVFFSDIVQFAALSSQMRPLQVVNLMNELYTTLDAIIDEHDAYKVESIGDGYLCVSGLPKRNGNLHGKECADMALEFMKALSDFRILDLPNERIRLRIGLHSGPCVAGVVGLAMPRYCLFGDTVNTASRMESSSSPNKIHISKATHTLLSANFDGYIMESRGEVIIKGKGVMETFWLLGHAENGALPANNAQQDRQPVTKADDDDDDGEEEMYRNYKQSMELGTSAAGDSGGVVVGGGYERGSGIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM63</accession>
    <name>A0A914HM63_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM63"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1843.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1843.t1"/>
        <property type="gene ID" value="Gr19_v10_g1843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037985056" evidence="2">
        <location>
            <begin position="27"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1843.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21525" checksum="72E416E8A962C51C" modified="2023-02-22" version="1">MLIKIGLFLFIFIKLLFVGIIDEVSSCGVELQDFGCCPDDICPVDLKQNCNMFGHNCVGCKFVFNKEHCTRFKVTCSCFYCCETQYRESCPDGCYECIQDGEGGCPQNTAKFKSIGNSSSLTLTSEAKAREHFNAIDVDKDGSISLSEAIEHLWPKLGNGTAAGNVAAKNVSWFAKLDRNGNNRIDPGEFDRSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMP8</accession>
    <name>A0A914HMP8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2008.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2008.t1"/>
        <property type="gene ID" value="Gr19_v10_g2008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2008.t1"/>
        </source>
    </evidence>
    <sequence length="854" mass="95721" checksum="827E303C7C7AB7E3" modified="2023-02-22" version="1">MQPNVAAHQAVQTQQYATPFYQFQPLQLEKFSGTKIRWPEFYESYKSAVAGHPIGKAEKFNILRNLLSGEARDLVAGFRLEDQNYDVALQLLKDTYGAPEEHIRALHFELANLKSCKNLRDTKEFLLQLERLTRELNNAGEDIEGPPTFLMLEKKLPPSFLRTILTKKGENPTHWTTTKLREVLNDAVRRESQIQEVMGEYGHHQPQPPPITAGAEFRHNNQLAHPQDHTFIQSAVDNIHKRLLTSPHTNYPNPPIPQLARAVPPTTQQHNRPPFRQPQGYNQPKPPSSCAFCGNNHWHEECRKFSTFEQRNAVVWEKRLCFKCLKTNHRASDCPSPKNCFKCRQLHPTALCRNGGHGSTKSTTAIDPINSRRGSESANATRADVMPLNGIRTEGLSQQCNATSDNEIKAVLMTTTSAVFNPAQPHRNMNATVFIDPGSHRSFITKRAAKQLNLPVVITEECHLTSFGARKSKKYVSDLVKLGFQGGGGQRHIFNLNALEFLVNDMPVIQLNKLDKAQLQRTTLAPPHLEKQPDIMLGMDVWHELQVRPIERLPSGFMLCDSTIGKILSGSGRIEMTEASNITFVGPVHAQAARKKPTCNQPTKKHSNKEKATRKSVQKKQHHIRLNSNSTTNVAPKATVSGDEHRRQEMEKALLRQHQRNKLFSNTARLRTIVTHLAAAQATNPPLIDLTSDINNSKMEYKSNSSEGELIDREKTEPISPARKPSASQPTRQRNPKVKQTLGLLMIISLIGLMAIHPNAVDTTNSLAEFNNASAAYEPCETESNIFSTWPALTQLFSSAAKCSYQSSTNDQFTIGHRSITSTGIGQPPRGRANVSNTWESPFGRSRPLRLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP20</accession>
    <name>A0A914HP20_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP20"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2911.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2911.t2"/>
        <property type="gene ID" value="Gr19_v10_g2911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2911.t2"/>
        </source>
    </evidence>
    <sequence length="100" mass="11652" checksum="46F091D530A6895F" modified="2023-02-22" version="1">MIREDQLLVCGEIAIWNAVRIEMQTKGIEDSCLFLNCLNGDRIHSMGLYCRLWRYNFAARDQLLFVNGEITIWKADTLLGGRRTMPSNGKKRVQRRIGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPB5</accession>
    <name>A0A914HPB5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3167.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3167.t1"/>
        <property type="gene ID" value="Gr19_v10_g3167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037756330" evidence="2">
        <location>
            <begin position="22"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3167.t1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48752" checksum="0397FF35124A0556" modified="2023-02-22" version="1">MKKFWGLILVSLFATISLDKAESVQLFDEIFGEGWWDNDKAKEWDKLTLEQNFHHQIDQQNTQIGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIGPNSTDQLGQIEPNSTDQNPPLTESDHSDNTKNGEEQSENIAKDEQKQKFDQMKAELKRAGFKNSYKNEINKSVANALGLNFTTIYNWKRELGQSVTNYSNNEKFEIVKKLMQIKSDNSAELKRAGFKNSYKHKIDETVAKELGITNRTIYNWKRELGQTKPQHNHNEQKQLMKRYYEIKDKNPKIRDGDIAKMLKIGTRTLIRRKKQFKRQLQPNSVDGLSVEENAAANVQEIENSNSGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPL3</accession>
    <name>A0A914HPL3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPL3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2533.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2533.t1"/>
        <property type="gene ID" value="Gr19_v10_g2533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037962148" evidence="2">
        <location>
            <begin position="39"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2533.t1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46302" checksum="2B98A012A8F77CB4" modified="2023-02-22" version="1">MKRSGRAEIGAAGSMKFSSKSVFLLLVSLLSTFEFGALTEFEEWVTVCQKMIDKIEKAPIIRDDTVNCKDQGATVDALQKLKEELNSLQKKVNDFMAGKSMPRNLFERLERPIENAKAYFKQLKKGVDDFGWETDQKYLDNLVPRIRSQILGLRAEFGTLAMEFQLKLIDQKDWRGGQDKADFEAKLHQILAFLKHNKTHCAEEPFEHAKAKIANFNEQEANEKLQNLVKMLILEANLSILENELVAKTHAFQHPQIDVSGFINFALQCHSELKRIKSVVADLPNDLEHQEFLKKLDAFPERAQEITQQLKLNILKELDELKHKISSTFNGVTDRQAVELCDEVMAVIRDICLPRLEIYMQIRRIKEVNESTICGTIFGKERIIELNDVVVVERQRQKVRSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPU4</accession>
    <name>A0A914HPU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3331.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3331.t1"/>
        <property type="gene ID" value="Gr19_v10_g3331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3331.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18302" checksum="3F6516C1BE568FEB" modified="2023-02-22" version="1">MSITKSTDRTPKLDKLNPIQLISLEKLNPIQLISLDKLNPIQLISLEKLNPIQMISLDKLNPIQLISLEKLNLIQMISLDKLNPIQLISLDKLNPIQLISLDKLNPIQLISLDKLNPIQLISLDKLNPIQLIRILLSQSMITLIMPIQAKILLKMSENMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQE5</accession>
    <name>A0A914HQE5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <dbReference type="Pfam" id="PF23309"/>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3286.t1"/>
        </source>
    </evidence>
    <sequence length="550" mass="61753" checksum="1D6DBFB96E49095F" modified="2023-02-22" version="1">MTEAVIQQLTQVLQQLLANQQQSPALITPPLPSLPNIECFELSEQRGRKVEDWLDRFNFAVDCSAPNLSDDLKVKLLMTKLGEDAYAEYSKSCLPKKVTEFSFAQTMEQLNGLFGKPQSVWIDRYECLRARKQDDEDFCTFVNRHKRLLRDFDFKKLEEEQFNSLMLLIALKSPSDAALRSRILAKLAADGDKVKYEGIVDDLKMYLSTIAEAKAIEQPSVVRNVLAVKSKPQRKRKNTENSSSGSNSSRKSQWSRSQHNCWRCGIEHSCRRCRHIKTVCRKCNMTGHVERMCAPHQAWLKKNGNGIREEKAANSVRLGGVFLVNSINQKHRLIEIPIEMNGKNVDFVIDSGTESTVLCEEAHRRIGSPRVSRCNERAKYPDGSTRTFLGKGLATFSIGGRTQTGRFFVSKKGSKNLLGTEMMEKLGLMDPIRRSLAGKLPADNVQGAKERHYQSAVRDGVIKKKPSDKHLRMTKRFALGATVIASQSNSQSGRAGYVSNRTGTRQDGVSLRKAPSENIAGEKADDGHGQRERLESDRPLLLVSDLNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS00</accession>
    <name>A0A914HS00_GLORO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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            <begin position="24"/>
            <end position="231"/>
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            <begin position="81"/>
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        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3194.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26425" checksum="B21D8F0BF5D684E8" modified="2023-02-22" version="1">MEEFWILILVAFFATNSLEKAESVKLELKTFDEIFGEGWWEKGEAEELKTPAPKNFGQNVHHQIDRQNTQIGQIEPNSIDQLGQIEPNSTDQSPHSGQIEPNSTDQNPPLTESYHSDNTKNNKTVAKELGFNFVTIYNWKRELGQTTPNKYPHSEQKELMKRYYEIKGQTPKISDEEIAKKILKIGSATLNRWKKQFKRQQFHPNSVDGHSVEENAAANIQEIANSNSGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS82</accession>
    <name>A0A914HS82_GLORO</name>
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        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
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        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
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    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
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        <property type="gene ID" value="Gr19_v10_g3476"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:cysteine-type peptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:telomere maintenance"/>
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        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
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        <property type="entry name" value="Helitron_helicase-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
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        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="219"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="920"/>
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        </location>
    </feature>
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        <location>
            <begin position="2124"/>
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        </location>
    </feature>
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        <location>
            <begin position="2243"/>
            <end position="2272"/>
        </location>
    </feature>
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        <location>
            <begin position="2358"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
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        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
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        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
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        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
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        <location>
            <begin position="2139"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2167"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="2249"/>
            <end position="2261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3476.t2"/>
        </source>
    </evidence>
    <sequence length="2483" mass="281032" checksum="633B204B8BC75827" modified="2023-02-22" version="1">MPSKQQRLRKMGKEQRLTDQSVSPGSQIPNSPRLDYSADGNEEASLGTTRALQISTPASATGKKRGRPPKAGNKGLVAGLDCVSLADTPNSTVPESATSSPCLKKEKSFEFDKKVITEVVSSTPVSTRGKRGRPFKKKGGPGRGKTVDSMSESSIMDESFVGNETMQVEEPLDDVDANLKLEKVACTSGNVPKHIDFNVVHINFAETRNFNCRIWRWAAIGLYADDDTLSGPRFIETCWNNPKEWLNDGFISMYLAYMASISQRKVVVLDSIVFDAAVSRVRGSYRNYTFGFDPSTPAEVILMPINFPGHWTILVNDIEAGTFFADSLQMSTLDTQKSNLIKGIIAELSSTTLESIRIDYVDNENLTPQHDGFSCGYFVCLYAEAWLMSQKTFILKNLNINFEKKRILWHLNELYSSDQVPYNPREGVTSPCPFVKRLAMEDVQSTSKILQSNVQLNDDSDDDIIIVDSPAKEKKADDIFFIDPPVHEQAVHPASAAMNAVLAEAEFPGENQADELALIVESCQAQEPIAQAGEVIFKRPKTPPRRSLRIKRLSNSLSRSPSPAAKRAPPTKGLGSTTRLTKRCHMVHKGWHCAAAAAKHFPDYFDSGELGEKKCPHCGAHLFQHEDSNICCRQGRVELPTLNPHPDELKQLIVADNQTREGKEFVRNMSRYNNLLQFASVSAGHKPCPAGGPMAVILNGEFHRRISSMQAGSTQTPGFGQLYILDPAEAMEQRRNNPTFTGEKITTNDEFVQGHKLNEKTLESLEKMIQENHPAAKAYKQAREQIQDLLKTQNAEELRFFRMTLLTERRAPAAVKDPKLHPNQIITPSTGEGMFAMHADPSGAPPPKGIWVENKQGQLNEIAPFSPWTDSLAYPLIKPLGDDGYTTGIKYTKPASRKRKSDVSTDHLFDSDVESDLESCAADSDASSDAGSIASGTSSVSGRFGKARQFVSLRDYCKYYLAIRDADVASGYHHILTCGGGLGQRWILDQAAKIDWQIATFLRRPDMDLRISTPRNLLQYLINQYNKQKARQNPNAERKSVDDIGSVVRLSEKNVNSLQYWKKMYEDCNTIFARYHDAKKARLFITFTNNREWTEFKQNLYKNGQVFTDRFDLWMRVWCSKIAVFRQELYEKSYFGTIIGSGESMEFQGRGGPHAHIVAQTDLDAIPEVIQEYIWAHIPSLPDKDDDTPIAQMHREIRELIHMQLHRCSDTWCGPKDSKTGRCKKGFPATYSKCTILHPDRPAVYFRPSPAEGGAQIEVNKLIYDNSHVVPFNPFILLRFRVHHNVLFAYGNKANIKYALKYPFKGPGHCYVECKEESGNKIGIDEPAQYAKMNFRGATEAYAVVNSIAFVRLSHQVVKLSIHLPNQQPIVFRAGQLVSKAQQIEQGELPETPCSAYWKQWQNEWKDDPEFKDMLFVQVPERFRWVKDKWVAYKIKLTKRPPIGRIVPVPPSDPERFALYQLMRHYPGDPDHLKMVNQQPCSSFIEAAIKHGLLEDDRVWNKTLEEASLSRWPDQMRWLFVSILVFGQPSNARELWDKYKQHMYHPQGIATMAQRQAKELQALADIDWRLFNFGFSCIHFGLPDPPNSIAKNTGKAIEEFFFGDDDLNVPPGLPNANKAEQNQPPPLNSDQQMVFDAVVKAIQTDPSDESVPRRLFVYGDGGTGKTYLFGQIIRRLRKAPYSHKVLATASTGCAAILLPYGKTAHSTFRLGREVSLDKLPSIPLESFFARRIREAQLIIIDEITMLNNTVIEVIDRVCKEMAIRQQKEILFGGKTVIFSGDFKQSLPVVPHEGLAAQVAACFQTSTLFGQFTTMKLTINHRLGQGQQDYMKMCRQIGHGETGEFFWIPPQFLVQSCEELIDFVYPDFQKLLGNDKELLNRLILAPHIQTCDEINELMMDNVPGQVREYFSTDKPLDERPLDIDEIESEVAALNQRTDSGMPPHRLRLKVGCVVVLLINKSDREGLINGTRIVIEELGEDKITGRAINGTAVGGQVRFFIERTRNVYEDKAPGGLKYERLQFPIKPAFAMTILKGQGQTIRTVGIDLEREVFSHGQLYTAFSRASDGNNVRVYAPNRDGCGDLPLRGFVVPIKDARLPSGRFKKSLKKCLLRSLSFKSDLGYMPSKQQRLRKMGKEQRLTDQSVSPGSQIPNSPRLDYSADGNEEASLGTTRALQISTPASATGKKRGRPPKAGNKGLVAGLDCVSLADTPNSTVPESATSSPCLKKEKSFEFDKKVITEVVSSTPVSTRGKRGRPFKKKGGPGRGKTVDSMSESSIMDESFVGNETMQVEEPLDDVDANLKLEKPSKFWYLYEFIVTFHYLYFPIFNQCFANFVECHLMFSLVPEVYGEINGARKPDMKQYREELKDMKQYKEELKDMKQYQEELKDMKQYKEELKDMKQYKEELKDMKQYKEELKEMKQYQEELKDMKQYKEELKDMKQYKEELKALKQYKKEFDIKQYKEEFKLYLFERPISDTDHDQMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS86</accession>
    <name>A0A914HS86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3990.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3990.t1"/>
        <property type="gene ID" value="Gr19_v10_g3990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3990.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39136" checksum="62B26904FC99E329" modified="2023-02-22" version="1">MNDFGILIFVSVFATNSLDKTESVQLEETPINPLDEIFGEGWWDNEKDEEWNKLTLEQTFHYQIDRQNIQLGQIEPNSTDQNPPLTVSDHFGQIEPNSTDQNPPLTVSDHFGQIEPNSTDQTDHSGQIEPNSTDQNPPLTVSDHFGQIEPNSTDQNPPLTVSDHFGQIEPNSTDQTDHSGQIEPNSTDQNPPLTESDHSENAKNGEELIAEDEQKQKFDQMKAELKRDGLKTSYCHEIDETVAKELGPSVRTISNWKRKLGQTKPQHKHSHSEQKELMKCYYEIKDKNPKIRDVDITKMLKIGTSTLVNWKSLFKRQQFRSNSVDSVEENAGSNVPEIGNSNSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSF6</accession>
    <name>A0A914HSF6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3801.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3801.t1"/>
        <property type="gene ID" value="Gr19_v10_g3801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3801.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31922" checksum="38046F3144B4E6C3" modified="2023-02-22" version="1">MIPLTTALSKLLNCKPENLAEYLNNPEAVNKASGYLGGKKLKTTYLSRDATTKDVKFGNFSLKSASDTYAFEGFLEVKVHQYFYIKHRIRLLYPQLKCVVEYHNKGHSKYYPLELLAIDELAEGGDKASDDHNYLDYLSFRTWQTPEFPEIEFNVNTMGLTVYCPRHLKTPRLVPWDQPGRCSRCRSGTVELDYFIQAEGVTVFSTRLKNGGEHFVPFDEIVDFGDNAKIRIRSRNKVFTLPLRQPEVWQAESVAGAGQVLAVQPPTEVIKDGEERKDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT93</accession>
    <name>A0A914HT93_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT93"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4448.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4448.t1"/>
        <property type="gene ID" value="Gr19_v10_g4448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4448.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="24842" checksum="2B420DFA79D7528F" modified="2023-02-22" version="1">MSNHLCFLCCCEQAKAMPVFTLIIPLQLALIVVASVLLILAQCCGGGGKKDKKKAAKQPAQGKGKAAKSASDMDPAMLSGKPKKQNAAQKKPPEKGKPGKQPARGKPAAHTPPSAAMDPDLISRSPPSPPPSAPKLTPVAAGDPNYGTLANLDAGIFVQHPKGGGGAPIPQQPKASPAALPTAAAGDPNYGTLANLDPNIFQRKPTAPAAGKPGGAATAAANDPNYATLKQSGPEHIQTALIGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU04</accession>
    <name>A0A914HU04_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU04"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3966.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3966.t1"/>
        <property type="gene ID" value="Gr19_v10_g3966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3966.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28358" checksum="BC7F04139EE20452" modified="2023-02-22" version="1">MTKIALQELGWEVLPHPPYSPDVTPSDYHLFSSLSNALSGVTLENAAALQNWVDEFFASKPPIFFKRGIEKLPGRHADGSGHSIGAKAVNVHGGDTGRRTFEFGNKRRTAHWRRTGAVGQLRTRHPLGRQNIRGEAARLYEWPEHYGARLRPIRSCQPVQPQEEATGVPTNPPQLRMPQGAPPLLQIPAAMRRQFIRRLYQEREHAYGFALQIARWNPALSLTLLSLEMFYSSLLAQALDEGDGGNFGAGECRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVX6</accession>
    <name>A0A914HVX6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVX6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4659.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4659.t2"/>
        <property type="gene ID" value="Gr19_v10_g4659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4659.t2"/>
        </source>
    </evidence>
    <sequence length="407" mass="46686" checksum="D162D31BA65F2737" modified="2023-02-22" version="1">MVYNASADLWYQYFNASGPQIWILIILFGVRSIWATIGILFNISLIYVTCCSKSLHGICNVLIALESLFGTTMDATFYYCFPIIIVPGVVMGNCAQLAMVLTGLDRLIAVLFPLWYKTRKGQRYFLFVALMLVVYSIYQFAISYIAYQTISDIMMSCSTTEKTTGNLAALMNANGYTLSAILMTFYGLLCFLVFKLSATAKNFNNESKKLVKAMVFIIAFNLFGVFIKCFVQFLFQFVVVDVFFKNYYGIAFSFVTIAVYSANAPVLYVISSEYRARFNKHFKWLPSLFIQKQTQHVGISTIVLKPNNYSVRLRNAGGPNFAPSGDATARTIGRAQWTRTIRRTMNAHDWMRTIGRAQWTRTIRRTMNAHDWMLTIGRARWTRTIGRARLDAHDGRARWTRWRYFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWG1</accession>
    <name>A0A914HWG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4656.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4656.t1"/>
        <property type="gene ID" value="Gr19_v10_g4656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057618">
        <property type="entry name" value="Znf_POGZ/Z280C-D-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25429">
        <property type="entry name" value="zf-POGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4656.t1"/>
        </source>
    </evidence>
    <sequence length="808" mass="92101" checksum="A0788A2BC55D4CCC" modified="2023-02-22" version="1">MLPNNHCEVITLSDDDGGENGNDEQHLSQRNNINISQYPHSQLRQQIRDRLKRANNEMQMAKQQQFMPQPTGGSVSLSIINERPLDMKKLMTTSRSLVPPHQLPPTPSQRPLTVKDQLIMFFQQQHKVHLQLEQKAKTSTVRNENGFPASFKNKISVQGLKRPVPEWRAQYNGPPSRTTHTNKRARIDISSQHGTLNIPSNNHIGTSERYVNGKRMASEVMSRFCNSYIEASNKRIQAGFGVIEEEFTGQFQCTFQSCNKRLKNNVLFMYHIWAHVAQQKPAENEEQCSNLQILLAEHNGAEDEAKADDQRTDVSRLHTCPECLLEQPTPYRARLHYHRVHKRGKRPLLDSKPELHVCNICEQVIDTKNMQHHIVAHALPNKRQLALPYGCRFGGGKCQFRTSNRGALLQHFCNKHVGTHVVLCPFCLMTFCVPPTHKRDSLVRMRDFVRHMIMHDAEKSSHCGHCVIKVAISQRTQMEQHQEQHTKNGEHKWLQWHMEQLDLNSVGPQPSHALISSDMNIQQCVECGQMVNNLCRHLGIETKRCKFCSFVTRCARAMDRHRLLSQCNPSNAVRRPFAAVAGWTFSAGNISCSTFSPSSSSSLSSPPLQQFGCAQCAFGSVSVQALAEHIAAVHATCSGAQVLLLNKINGRQQRLEEQMMLNRMGEDGQGGDKMEQDSKEVGEDELHEAELFGLLRMADVPLENNDDHDDDEGNDEDKQQRISADKQAELRDWLSEFLPLVRANELSQREIQPQDVRLLKQLLEMDRSGLSPDDQRVQRMAEEKHELRVKMGLMHDDFPKLDFKTISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWY2</accession>
    <name>A0A914HWY2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWY2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4785.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4785.t1"/>
        <property type="gene ID" value="Gr19_v10_g4785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4785.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13550" checksum="81F8EC089AACC176" modified="2023-02-22" version="1">MNLEKLMRNKVESLQKKKKQYIAAEQSTIREEEETNQSILHRDSPIASVGDENLELEDPRRAKRKTSKIFGQARKYVTARFLSTSTNVKKDSESMLLLYDSRISRPNQGDVVLVPKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWZ8</accession>
    <name>A0A914HWZ8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4912.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4912.t1"/>
        <property type="gene ID" value="Gr19_v10_g4912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055189">
        <property type="entry name" value="RM44_endonuclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22935">
        <property type="entry name" value="RM44_endonuclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="15">
        <location>
            <begin position="386"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4912.t1"/>
        </source>
    </evidence>
    <sequence length="1051" mass="120635" checksum="04261A9256453790" modified="2023-02-22" version="1">MPSKEEACLENSRPLRDDPFGQRYLRDECAVFDYNAWDDVDWPEEREAEIQRTIQAQLVDAVPESVSLGLLQNPKERWESFFETHSNKFFMDRKWLTREFPELFSRPQEDGLKVKVLDVGCGVGNTTIPLLESTEHLFMYSCDFSSKAVETLRNDKRIAAERCQPFVWDITEASQQKEVANGTLDFVLCIFVLSAVHPDRLRSAVLNLVELLRPGGMLLLKDYGRHDLTQLRFKSSRLIRPNLYRRGDDTLVYFFTTEEMDALFKEAGLEKIQNFMDKRLVVNRAKRNKKILLKLCCEVAKHRPWLQKLACRPAVKVFIARQNDKNPTRALVLIFELLFGKWKDKLPTGGGKDKQRLATLRGLKGVLQEEANLLQTESVSPESLVPSVFSASLLPRYVRVNTNRTSFSQAVEQLERDGWRLRRLKKGITPSKYRKLVSNLERPKVYADPHIDDLLIFPRGVDLHDYCLVVEGALILQDKASCLSAFVLQPEPGASAMDVCAAPGMKTTHLAAIMQNRGKIWAFDRDQKRVELMRQIIDKTGTNIVNEACIDFLRVNLLDAKYKKVKFVVVDPPCSGSGMAKRGEHFDEFEKPDEQRVKALANLQVMLLKHAFRLPSLQRLVYSTCSVHWPENEGVILEVLSIPAISNRFRLINALPQWRHRGQLGESGDTELENLRNSSRHRSAEVWRRAYLKDLFHRRQLLGPDPMKGRASEDNWNYPSEISALSHRLHIPEMDDTLIVQALTDKSYFTRKDLNNDGMGPLADDEGEEGRSSIAKDPSNDELVDKGLSVFRHILLAYLRAHWPVAPEEFIVCVASRIASMSALVELATQLGLHHVSTLLALVGAMEMAKARDFVRRLVLPRLYEVPLEDVLPFRHPFAVLTDYMRKWEGITDLEVRTIDSGAVLTATPFYEVAIYAEKKRIVGQHGGELPWVALDLAAQNGLLRLWRVSDQPRVFPFKFEEVYATRFDKAQQTNHRLRDVCGERTDLRLYTPDELARDPIDMTKMSKQYFTKIKPKVGIPHRRRQRHMFSRGTINRMSFRAFVKPTPHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXI4</accession>
    <name>A0A914HXI4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXI4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5388.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5388.t1"/>
        <property type="gene ID" value="Gr19_v10_g5388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036695928" evidence="2">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5388.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8921" checksum="7973ED8B7426AB75" modified="2023-02-22" version="1">MKVQCILCFFLLSELFVMPVVVHGKPVKGKKLVEKRSTSGDLARTAVLGAVSAKLHGGSRQQNYEPPQNHSNRILLYGTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXK2</accession>
    <name>A0A914HXK2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXK2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5404.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5404.t1"/>
        <property type="gene ID" value="Gr19_v10_g5404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054138" evidence="2">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5404.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="10739" checksum="3EBF312AF40FCABF" modified="2023-02-22" version="1">MRNRYISTHKKMNRYGLLCLLLFVNAVIVPIVNSAPLEREKRLTGAQLGKGALVGAGIGLVGTALFAGGKKFMDNRKANAAAAAAAGGADAGGTDAANLKKKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXL2</accession>
    <name>A0A914HXL2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXL2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4968.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4968.t1"/>
        <property type="gene ID" value="Gr19_v10_g4968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038033677" evidence="2">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4968.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="10918" checksum="2228B5D60445F758" modified="2023-02-22" version="1">MKFMLILYFAIGVKLAMNAPATDPKGECSDGEIATECRPVCGEKSCADILAGGAGGVRKCFSLRCFPGCVCASGIRLFEPNGGKGQCVTKERCEQMEKATNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYF8</accession>
    <name>A0A914HYF8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-glucuronidase</fullName>
            <ecNumber evidence="3">3.2.1.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the degradation of dermatan and keratan sulfates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.31" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HYF8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5186.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5186.t1"/>
        <property type="gene ID" value="Gr19_v10_g5186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000080">
        <property type="entry name" value="Beta-glucuronidase UidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="9">
        <location>
            <begin position="97"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="7">
        <location>
            <begin position="239"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="8">
        <location>
            <begin position="332"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5186.t1"/>
        </source>
    </evidence>
    <sequence length="648" mass="73293" checksum="217C9C89F11B7397" modified="2023-02-22" version="1">MSLCTEDAAGPSLIVVQRKFLVSNLPGGECILGSSKVTAAMSYVQGAFFRCFVRGSKRTPAIGYVGIGLRNNWASLDLAAFENSSLIPVPAAYNDLTADSEQRDHVGWAWYQRKYFLSHFLLNASSRRSFIRFESVHYYAIVFFNGEVVAEHVGGHLPFQVEVQLTGLNLITVAVNNTLSRDTIPPGDFSTIKLSSGRELVNLVPHFDFFNYAGILRSVYLWHLPQILIRGIRIQADHSGFFSYRIDIDEGVHTKKGIKIRVGIYTFEEETKIYELVGAQNSTSFAKIELWWPKGMGSPKLYTAEIRLESVSSDGSERLLDVYRETFGFRTVTVDQNRIYINGLPFYCHGFGMHEDIGIHGRGFDRATMVKDLNMFDWLNGNCYRTSHYPYAEERAHLADRMGIAVITEVPAVGIWNYKSPSLLQLHAKMITEMISRDRNHPSVIMWSLSNEPKMPVNSGADVYFENLVILSKQLDSTRPVTVVFGQESTEVKVASLLDVICVNDYFGWYRNIGMLELIQDRLIGQIRSWRHNFSRPVILSEYGAEAISGFTEQPSVAFSEQYQAELIKETGKALDVLRCSNDIAGEMLWNFADFMTAPSVDRVIGNHKGVLTRDRKPKLGAYAIQKRYKKLLENTTPTAKVCFDPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYS3</accession>
    <name>A0A914HYS3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HYS3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5275.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5275.t1"/>
        <property type="gene ID" value="Gr19_v10_g5275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="185"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="374"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5275.t1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59879" checksum="BE2DC540166E60F4" modified="2023-02-22" version="1">MAQRLFLLNPKCFASLLIRHASRHESSGPSFDFSYDKQQHSQPLGDQRTFYVQHKRNTGRIGGDTQFNHSPSRGQYRQNNVTGFGGRPRLNSFGKKNFDLQLNRINWKDFELQSFEKKFYKPDERVIKRDQSEIDTWMLDNACTLQGNDLPRPVLAFDEIGFPSRITEHLCKKFVKPTSIQSIAWPVALSGRDMVSIAMTGSGKTLAFILPAIVHLLGNTPLQPRDGPKVLVLLPTRELAKQVEEVSREYCQMMGLKVTCCYGGAARGPQEYALKQGVDICVATPGRIMDFLSSGVTNLRNCTYLVLDEADRMLDMGFEPQIRSVVGQIRPDRQTMMFSATWPRDVRSLANDFLTSPAHLNNVEVIEEYSKQDRLFEILRDIQAQPECKTLIFAETKRKVDELTRQFRRNGLAALCIHGDKTQREREWVLNEFREDRSQILLATEVAARGLDVNNIKYVINFDYPNNAEGYVHRIGRTGRQDKTGTAITFFTPQDGPKARELVDILEEAKQSVPDDLHRLCRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I013</accession>
    <name>A0A914I013_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dendritic cell-specific transmembrane protein-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I013"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5615.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5615.t1"/>
        <property type="gene ID" value="Gr19_v10_g5615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF9">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26039">
        <property type="entry name" value="Dcst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="6">
        <location>
            <begin position="440"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5615.t1"/>
        </source>
    </evidence>
    <sequence length="781" mass="90152" checksum="22A3E6408751A2E7" modified="2023-02-22" version="1">MTTAVLWEFYMAKRTAVANAKKFEDKTTKLRKRRGLLPDDGTGRVDVSDGEQTPLRQRIATREGRQKLLKQIKEMKNRRPKDSKVRSLLTFILVFFIMQIVNILYFHFIALKFPGFAELGGGNYLSMAVQFLLLLLIVFRPLRFVLFVALPSLLTGRLRSIIVLMMIIWGFQFPAKNVTNNIDSVMEGVGCVVVHIKEAAQEIKQRAGHKLYEEPVAKMREFLHEQAKPFDGIRASLREMDESLTKMMAWQRALAARINGMMSNCTHIAQLPFKACIGWLTERHTDCLNRFLEFLCAPVDWAKQLCYLTKMLQFHCDWPSAVKNTVKEGVGYFVKGAKKGITDYAKSTFMYDLVNKTTHLGKETFQTLDILVEHNVNETDGIAFEKDSIQRELKDRVKLFNRISNAIVWTLDLLMLFTTIWPFLSAILYIRAFVRSDDADNRFIGKDFKQIDDARALSNQQTVLPLLPKERKTYIRATTVHMTRRENVSLCISNLFLLYSMVPILVFIAVDVFVYRLINRTFVFFHGNATIFPRPNIYALKVSGDGFLNQMLANILHTFEPINDDARDQLWRRCFKEPSRPNYELFQTIFYLYLFCVLLINVGVYLARVRHFVALYYLPERAYPRAINLYTKIMEGRKDMFDLVMNIRQSTTNEENVGEHERQLLFKGLSVITEEKLRCYRCSRVDLSIAESSKVRICAQCGSVYCLDCFTIRKNCLRKECRASLQAITEDVDLYVDSSCEEDESSDEAETVDVGGKGVTSIVSTVSAFNDYRHAPDHDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I043</accession>
    <name>A0A914I043_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I043"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6258.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6258.t1"/>
        <property type="gene ID" value="Gr19_v10_g6258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF262">
        <property type="entry name" value="CUTICLE COLLAGEN 34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="63"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6258.t1"/>
        </source>
    </evidence>
    <sequence length="397" mass="37980" checksum="ECEAD789AD6FBF43" modified="2023-02-22" version="1">MFKIAAFPTKETKSVSNNCFVLSRRAQNLSGQPTVAPKPIYLAGHNQLAMNIELESRNKAYRFVAYAGVCFSVVAVISVCVTLPMVYNYVHHVRRSMQEEINYCKGSARDIWMEVNQLRNSPATAAGNRTARSTGYASGAGSAGGGGGGGGGGGGGGGYASSSGGGGSGGGGGGGGGGGYATTGGTSGGDGDCQPCCSPGPPGPPGTSGRPGRPGKPGSNGMPGSPGKPPTQPCESVTPPPCRPCPGGPPGPPGPPGQPGDAGGPGQPGTPGSDSGAGTPGPKGPPGPPGQPGQPGSPGEPGQPAQSQPIIPGPPGPPGDAGPNGPPGPPGNPGSDGGAGQPGPKGPPGPPGPPGNDGQPGTSGQPGQAGGQGEKGICPKYCANDGGVFFEDGTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0D2</accession>
    <name>A0A914I0D2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0D2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6147.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6147.t2"/>
        <property type="gene ID" value="Gr19_v10_g6147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="855"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="940"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="792"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="964"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6147.t2"/>
        </source>
    </evidence>
    <sequence length="1148" mass="124861" checksum="30B11FD9C7611EFD" modified="2023-02-22" version="1">MHKMFFYSELMMMHSSQDPSNSYPQHCNNNNAHQSPEGTTALPPEAVVAQQMISANVALLQNGGVKNEEVKKESTGEEESDDEEMEDEEVEDDDEEEEEEEEEESASGEEERQRHAAAGPTEGPKMHMAEPGAVAGAGTAPAGGELQTIRANLQILNHQMALLMRTLNVASCTCAECQDAQRVQHCVALPAANGNSSQLQQLHAAGLNMGGTSGGISSFAPGTPHNLQQQHQNLFSASSGGGTDVGSAGDSAPRGRRSKYCTPEEKKAVASYVQCHGATAAARKFNIPPAVAAYYHRKEFKKQGVAARRSSVSVHHAQQGQQLQAGDGTKVELGDGQQGDESGMEQIGQLWQNNYGGGYLRGRGRGRPKLIGDELDAELVEYIVQLKQTNPRAHITAAQALVIARKYIAEKAPGLLEENGGQVKLKITWAMKLVTRVQEREREIQLGLPAGSLQNLPRSAFSNAAVGGDQQQSSASSALVNELLGQNLMGNQQIDVNALLAAAAAENPQQIDLNDAAVLNLLGMAAGGSDLFSSNGGGGGTGMSHEHPGCTSTGVGGQSTSSAAAAALQQQQNQRELAESDEAIRQLLSSLQGGGAEHVGGAVQHQHQQRARDGAAGAELSVADLSGHVLKQNAMRLNNNKNCLPLLIVFLTLHIILICSKEEKKDSTRPRGVSPQLAPLYQERAEFECLDGKKRIPFEQVNDDYCDCADGSDEPGTSACKNGQFYCANFGFQPQTLPTGRVNDFICDCCDGSDEWDSGIDCPNLCDALGSKAREQAKQSAEVQAAGYAKRRELAKEGAKMLEEKKLEAEKTKNELEELTELKKGAEEAKKEVEELEKEAKDSQEKEWEEAKKELVRLQAEEMFGKMEKDGDGKISSDELKRFAGFADGGDSSERAKELLKDLFKEDSEGGGDEQIDNTLLNFDAFLEKFEMAKEFVEEITEEEAKSAATTTAPEADEDKRSAEEEDDKSEESDDETRKKYDQQTRQLIEKAEEARKEYNEIADKVSDLERTVRDSESFLNVEFGADNAWAPLKGKCAELTTAQYVYILCMFDRTVQKERNGHAEISLGHWGKWAGPEDGNKFKAQLYEHGQTCWNGPERSTFVQFECGEELQLVDASEPSKCEYHFLAKSPTACADPEELKGEHAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2D8</accession>
    <name>A0A914I2D8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914I2D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10949.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10949.t1"/>
        <property type="gene ID" value="Gr19_v10_g10949"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6869.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6869.t1"/>
        <property type="gene ID" value="Gr19_v10_g6869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10949.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6869.t1"/>
        </source>
    </evidence>
    <sequence length="383" mass="42564" checksum="83A9FE0AD46F68A8" modified="2023-02-22" version="1">MMTTYGNDLSFVAISWTATGAFALLANRRVWFRRHRLPRALLAFVVACALCAFAVATRTAPWRIPALLWRRVFDGTYVRLCLLLFWLLCSCASLLFIVLVRHRLSVHHQQRHSSVARVGTGHRKFFHLTASLVTVSGLLHDPPFLAFCVHFVLQIFIIVEVLRSQRVQPFCWLDDCLLMFIDGQDSPELIMTPILLLVGLNLPILFDLRLLMAQNAAVCWTLRQWHFAGVISVGVGDSAAALIGSKFGRIRWPSLFDIADDGTALQQQPLLIDAAAEGVTANGQPHGSQQHRRAAKNAKTVEGSMAMFITQIVVAEGLLLFNSTGFSTRPWLNDGVCCSVSSAVPLVAAAFIATLVEAQLPRFDNVLVPLCSMLTFWLLEWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I307</accession>
    <name>A0A914I307_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I307"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6140.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6140.t1"/>
        <property type="gene ID" value="Gr19_v10_g6140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037701200" evidence="2">
        <location>
            <begin position="18"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6140.t1"/>
        </source>
    </evidence>
    <sequence length="456" mass="43617" checksum="F86F6C58F55F3BE8" modified="2023-02-22" version="1">MTVFALIPLQLMFIVVAAVLVIITQCCGCKKKQAEQPPPVKPAADQQDAASKSLSSKPAPVTENVTGKVPPPVAFDLGAITKIVPTSSSAVNKNASPTGPMPSAVMGSASIKSPTGPTTSAVMGAVSIKSPTGPTTSDIMGAVSIKSPTGPTTSAVMGAASIKSPTGPTAVQGTLSQRSSREPSTPAQTATSNEPPIGKLVLDNLFFKKPPIPETNVTSKAPPEAFDLDIISKIGPTSSSTVDKSVASIKSSIGPTTSAAGMGAASTKSPGPTASAAGMGAASTKSPGPTASAAGTGAASTKSPGPTASAAGMGAASTKSPGPTASAAGMGAASTKSPGPTASAAGMGAASTKSPGPTASAAGMGAASTKSPGPTASAAGMGAASTKSPGPTASAAGMGAASTKSPGPTASAAGMGAASTKSPGPTASAERDEDICSDLTPIYDRCKERCIIVIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I426</accession>
    <name>A0A914I426_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I426"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6625.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6625.t1"/>
        <property type="gene ID" value="Gr19_v10_g6625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036689449" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6625.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9472" checksum="D4162EECF06EF554" modified="2023-02-22" version="1">MLISGIFVLLMAARGAECGCAGSKPAVEGSIEAYQDDADILCAEKTNKKACEDSRSESYTHEFNCVWSNGECKARSTRQYYKYTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5C9</accession>
    <name>A0A914I5C9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5C9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g704.t1">
        <property type="protein sequence ID" value="Gr19_v10_g704.t1"/>
        <property type="gene ID" value="Gr19_v10_g704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038093572" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g704.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8254" checksum="6FFC2B4746F701F4" modified="2023-02-22" version="1">MFQMRSLAFLLLICLGAMVSWNNAAIMLTERQAEAVQQPIRARRDYDDCPNSQHYECLSTNPDGTCGRWKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I601</accession>
    <name>A0A914I601_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-rRNA-processing protein TSR1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required during maturation of the 40S ribosomal subunit in the nucleolus.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I601"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7634.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7634.t1"/>
        <property type="gene ID" value="Gr19_v10_g7634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7634.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15373" checksum="9F17F2120F961DA8" modified="2023-02-22" version="1">MDAGEEGEYAVDDNDADEMARERFRLQRENLQWPDEVETPRDVSARQRFQRYRGLKSFRTSPWDPKEDLPRNYARIYRFVNFKRTRKLALAEAHKAFDAEVGSGEFAYPGTFVTLHIVNVPRQIFALPCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I660</accession>
    <name>A0A914I660_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914I660"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7258.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7258.t1"/>
        <property type="gene ID" value="Gr19_v10_g7258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000518">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="9">
        <location>
            <begin position="39"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="147"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7258.t1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44295" checksum="BB72F4310D4F751D" modified="2023-02-22" version="1">MISLDSDATFAAQLQALPQQQKTTSSTMESDEEMWALPYYHGLLPREEIEDLLTRDGDFLVRKSEENPGERVFVLSVNASGQVSHVIFRHQRGMLAVDFNNERGYRTIRRFVEAHLKAGDTINSEGFVVLRHGVGRKSWELAHSTITRSESELGRGAFGVVRRGKFTDPKTKRTVHVAIKEVSQTCTKEQVKEFMNEARIMRQLDHKNVIKFYGVAAGQEPLMIVMEVATEGNLTDYLKTKRRGARSKLFMCLGAAAGLDHIHQKGIIHCSVAARNCLYSDSIVKIADFGFAHKGARKTMEVSRPVPIRWLAPETISDHYFTPKSDTWSLRKSPVVGEMVLAGERLQFPVDAPPVFIDFIVENVWNDNHSLRHSMGAVFDWLDRRVNHMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6T4</accession>
    <name>A0A914I6T4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6T4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7286.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7286.t1"/>
        <property type="gene ID" value="Gr19_v10_g7286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="267"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="333"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7286.t1"/>
        </source>
    </evidence>
    <sequence length="570" mass="64786" checksum="87150CE214CE6D13" modified="2023-02-22" version="1">MNGNEQKLHSDTLSVLELWTRIHQQRSAEVYDPEAVVQLFDLLEQTQRRRNISVQENGNLLDQISRLKRQNEKYETALDQSNETIRQLRADLAAKSSKIDSLRTELQEHQRVFQAANNELQSAVGLQCVDQRIRSETSRRYDRSTQKGKRRSSSPTMMSSVAGPSKRSRHIAERINEEQQQDDECTESEGDQQRQRSRPSKLVLGRRAMNRSMSESNVYEPPVGAQQQHQIKAPLSAKHISIVDMRFSPRACLGRGWTKGRPVNQCMHNYVPISNLFSAAFSYCSVCARGLGMKGFRCNDCKLQLHDYCRNHAPMPCVSIVPTPQRCHSRQRPTLGDLAPVLPPRIPGQIIRCVFALEQGFIGTVGLYRVPGCDSEVKKLKEQFNSKYVPKLDQIDPETITGFIKKFLRDLREPLIPFSSYKEFLKAAAEGNEVQLKTSIEELPEPNRDTLAFLCAHWQKVAMHSNENQMPLENLAKVLGPTVVGTTSKLLTLQDKQQQQATAYFMEASRQIQILQALLNLDRAYWTEMYDGPANLNGDEELKSKQQWPSTPTSSRSGREGGHLVQSIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6U2</accession>
    <name>A0A914I6U2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6U2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7842.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7842.t1"/>
        <property type="gene ID" value="Gr19_v10_g7842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037342737" evidence="3">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7842.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20128" checksum="68B5AE0B2BFAFC23" modified="2023-02-22" version="1">MPQWWVMFVSTSMFIFCCDVVASANDDGWHRAARVKRQYYDDNYYGSYYGWQAGRIVGWLIGFLVLMLIICVPCVCCVGIWFLGWFGLRQAMANRRVRRREEGVGGGRVMSARDQQEISRRYIDSPATAEQRYVYATDRVYAAERRPRTPPTVHESGGGNTAYASNGVTREVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7B7</accession>
    <name>A0A914I7B7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="4 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4 18"/>
    <dbReference type="AlphaFoldDB" id="A0A914I7B7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7579.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7579.t1"/>
        <property type="gene ID" value="Gr19_v10_g7579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000029">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="17 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 18" id="KW-0408">Iron</keyword>
    <keyword evidence="14 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="58"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7579.t1"/>
        </source>
    </evidence>
    <sequence length="674" mass="75856" checksum="C1D19283F4813E9A" modified="2023-02-22" version="1">MFIRRIVKQNNVLISEDFDGTLLDSPKIVMLFSKIPPSFCTVLRAASTSSPARGPNVKTFEIYRYDPEKPEQKPFLQKYDVDLTQCGTMVLDALIKIKNEMDPTLTFRRSCREGICGSCAMNIGGENTLACICNINKDTKYSTKIYPLPHMYVVKDLVPDMTLFYEQYASVQPWLQKNRPTELGKIENFQSQAERDKLDGLYECILCACCSTSCPSYWWNSDKYLGPAALLQSYRWIVDSRDDKAKERLARLTDPFSVFKCHTILNCTKTCPKHLNPAKAIGEIKKLLTGIDTKPEPKQASNKNICSVRAVKDAQQLEGESKIVEEKRRCWGNQNGEEKARWYSEGEQIESGTFVYECRDTKVVPVGCLDESGRQIGLKEIFVSKGLLMQCSLSRWGSEVQLKTIGCVLEGKQNKSVVPVGKNWAEKESQTWWECAVEGTAVRARLGGCLDLETLSRLRIGESIDRGRTTFECQSKGADVVKMVAVGCVSSGGEHQRIGQQWQDGDFLFYCKRTAAGACEKSCVGCVLQGRRLYDGDRLQQKRTVFQCEIRPKRHALSPVACVSESGVERVIDCKWNDQSKDGTYRLKRHCVLREGRADIDTLGCVFEKDGVSRLTLKAGTFTIWREAMNISPLGVSCRRALVDGDEWPLLETFSASEVADRTNGLTEDIDPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7N2</accession>
    <name>A0A914I7N2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7N2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8253.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8253.t1"/>
        <property type="gene ID" value="Gr19_v10_g8253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8253.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="22211" checksum="B27082891BEBAD93" modified="2023-02-22" version="1">MDGCVKLEDDDGGGGKAAGVGDEVGDGQEGGGRGMKLEMDTRGRGDKLGDGQKGGGRGDEVGDGQEGGGSGDEVGDGQEGGGSGDEVGDGQEGRGRGDEVEDGHEGTWTLGDVGVKLKMDTRGRGDEVGDGQEGYVGMKLKMDTRGRGDEVGDGHEGTWTLGDVGMKLKMDTRGRGDEVGDGQEGYVGMKLKMDTRGRGDGTRGRGDELGDGHLGTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I983</accession>
    <name>A0A914I983_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I983"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8070.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8070.t2"/>
        <property type="gene ID" value="Gr19_v10_g8070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8070.t2"/>
        </source>
    </evidence>
    <sequence length="177" mass="19589" checksum="CA72E5CF8C199A46" modified="2023-02-22" version="1">MVEPRHRSPASVIAGTPQPGKFMKGRTAHGQAMGEISIWRCAGSATLRIVSQMEGKTDHTRISGRHILLEWEQLGICSVHETFMDRKNGWYDTKNDTIILSAEVTADEPTGVDGFMRFACDIIVRMLLLVAVTQFVSSVRIMLGFPPEGSVMHGKTMPIGRTNMTSTSRRTVLLNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9J0</accession>
    <name>A0A914I9J0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hypoxia up-regulated protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9J0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7949.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7949.t1"/>
        <property type="gene ID" value="Gr19_v10_g7949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037869927" description="Hypoxia up-regulated protein 1" evidence="7">
        <location>
            <begin position="25"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="710"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="710"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="783"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7949.t1"/>
        </source>
    </evidence>
    <sequence length="812" mass="90936" checksum="3B236DD447424204" modified="2023-02-22" version="1">MNLYRRIFLFVAIICASCPQLSTANSAMAIDLGSEFMKMALIKPGVPMETVLNRESQRKTPMALTIKDGERFLGETARKKALSMAQHTFAFFLDLVGKQMDDPIVAAFQAQFPFLTLKAHPQRGTVQFGTDSGDVSVECALGMVLWNARQEVEAYAGQPVRDAVVTVPAYFGLVERAAVEAAAKIADVNLLQLLSSGTAAGLNYGVFRHKEITEQPQRLLIYDVGSTKTLVTIVQLRLVNETTTSTTTNGKNATKSGSNKAASGSFPQVETIGVGYNRTLGGYHLTLRLRDHLVKAFKQQYPKLEGDVTQNPKAMAKLLKEADRVKQVLSANSQHFAHVESVFEDRDFRTKVTREELEALFHDFESCYLEPINDALRMADLTVEQLDRVLLMGAGTRVPRLQTILSTHFHGKELSKQLNTDEAIVLGAVYQAARLIKGFRVKPFEVKELFLPHEVDVSAEPPSFTKWLSSLTVDDAQLQHNMSTVIGDDEIKEAKKILSTFERNEKAKMEHALALNSLESAVYDYTAKLEEDSFSGFGTEEELQLVHQKLKEMKDWLEDVPNETSVEELKQKRREVVAPIRKLKSRKRQKEDRPALMEKLTTTLDEAEKKLQLFTTSKEFFTEGELTSYQHTIETVKVWFDGVKKELEQLKDNQDATFTTDNFKTKTNSLIGEVRFLASKYYAAALKLREEAEADARKAKLEAEAEAKKAEAEAKEVTKDDDKAEAEAKKDEEDDTKKEAEGADKKEAEGADKKEAEGADKKEAEGADKKEADEDKKDDEEAQTEKKEEGKEDKKEAETDQKESGEGIKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBE5</accession>
    <name>A0A914IBE5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBE5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8337.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8337.t1"/>
        <property type="gene ID" value="Gr19_v10_g8337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8337.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9101" checksum="40762CB6B9B3CAA2" modified="2023-02-22" version="1">MRPENALRKQGMDSGDEGNKSMNESVMQGSEELWTVKRVKCLLTIPDNPTTPSHGESFSIPFKAMDDLRKPYNSNRERLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBH4</accession>
    <name>A0A914IBH4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBH4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8356.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8356.t1"/>
        <property type="gene ID" value="Gr19_v10_g8356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044716">
        <property type="term" value="F:8-oxo-GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769:SF56">
        <property type="entry name" value="8-OXO-DGDP PHOSPHATASE NUDT18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769">
        <property type="entry name" value="MUTT/NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="116"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8356.t1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48058" checksum="383F1D1CAA2782BC" modified="2023-02-22" version="1">MFLYVKYILGAGSSTSTIFCVSIINRNSPSPPPAPIEGENPFNSDEPSGDDDSSVVPLNDLDRDHRRPQLNGGGISSSSATSSSSASKSSVSTNPARRAPDMQMGKCPWVRVYDNVTYIVSAIALRDGPRGREVLLMREAKEKCRGKWYMPAGHVEPGETLEEACKRELREETGLECAVETLLCVEVRGSGWYRMAFAVEPNGGELKQEPDQESLGAGWHPLELVRRKRNDADGLQLRCRDFMSILAEAERYADWKRRMGLRGISAALPWAPILNRDEAQPGLFVDFVIVRQSVVSNRLECLVHQCVRDQLQLLDELTLPDAFPSVEFGFEFFLPSVITKVYRHVLDDGHCVLELPEAVTALWCLPAPMSSVRHGIRLRLLCRHKRSAQRGQILAPQRYRWIELDHPEVLSTLYLLDEQFRPKLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICB7</accession>
    <name>A0A914ICB7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICB7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9516.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9516.t2"/>
        <property type="gene ID" value="Gr19_v10_g9516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037288235" evidence="1">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9516.t2"/>
        </source>
    </evidence>
    <sequence length="75" mass="8162" checksum="CA45F870FE0F73D5" modified="2023-02-22" version="1">MFFRLFILFSVLLTHFGTAAPNVGKISANILQQQLNAEYVVVISDPITSADVGAISVSENLPKLTKNEAVYHLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID88</accession>
    <name>A0A914ID88_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ID88"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8809.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8809.t1"/>
        <property type="gene ID" value="Gr19_v10_g8809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="327"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8809.t1"/>
        </source>
    </evidence>
    <sequence length="684" mass="76832" checksum="3DA0B6DAF4D50C8D" modified="2023-02-22" version="1">MTSLNEKGTHSRLAFVPFVTFTDPLFWNEINRLKVDKWRLDESERPIVATITFHGSQPSDGLLSFDQHSIAEEVDRTVPKQAVQPSVLSLHGTFLLLNTKKAFLEDFNRKEFLERSAESLWKIIESKEWLTETQRLNPFLLTAWADVKNFSYSFWTCVPALVFPDNLRQLSLDTSPNVQLHKISLEFIAKNGCHPFLLIDDKDPVELKELASVDSAENVLLVFPNPSRVKYQVGWPLRNILAAIARLRTDFTNMRILALSRLADACFIVNIGWDPVDEIVGLLPRCVGWERDSTDKLTFREVNLRAMFDPIKVLEQSVELNLKLIRWRHAPSIDLQRFASLRVLLLGSGTLGCNIARALLGWGVRQLRFTFVDYATVSYNNPIRQSLFTFDDCTKDGVSKAEAAAEALKRIYPLVDAKGLHMKIPMPGYPYSSPEGERRVKEECLRLEECVRNCDVLFLVMDSRESRWLPTLLAAAHNKLAITVALGFSDFVIIRHGANPPQSVLHDDALLTPSISVSDAFPSTSGDFSISKGTEVSGAELGCYFCNDVTAPGNSTNDRALDQQCTISRSGISMIASGFATELLASVLQHELGAEAPALLANVDEGATQLGATPHQIRGFLSRFHLMMPTVRRYDRCTACGHTVRQLYRAEGFAFLDRIFQNPVELEQITGLAELQRQANEFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE47</accession>
    <name>A0A914IE47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9049.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9049.t1"/>
        <property type="gene ID" value="Gr19_v10_g9049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9049.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21648" checksum="B4907C80CD830624" modified="2023-02-22" version="1">MVNSIRSIVHSFDWVAFVFGISLNGILTRLILRHTPKIMQIYSKILLQTCLVDVLVNVTGLLFNSYYIVTRNGAHEVFLDGLFTLQGTAEHRIWALLGFVCLTFLLNVSILGYVTQFIYRYLALNWDKKLSSWKYFKHEDDNWVLLFCHAVNNRLRHYIYVGFSYAQIYEGAIKNNNFFKTSSADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE73</accession>
    <name>A0A914IE73_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE73"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9079.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9079.t1"/>
        <property type="gene ID" value="Gr19_v10_g9079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037938868" evidence="4">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9079.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="20315" checksum="0887FDD25CED1DF7" modified="2023-02-22" version="1">MFGCAFLFICIINLPLSDGDFFDDAINWVGDKVVKPVVGVLEDAAKLAVDVANDVAVVLKNAARGLAIVSPGLGIWVSPPDCTFILGMAAAGGGDPTTTSTTTTTTTTTTVTTTTPKEDEDDWAISDECKCPPNEEPGQNSCNGCEPKCDDDDDSLLDCTLMFCSCSCDCKNGLVRNSRTNQCIPQEQCPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IER7</accession>
    <name>A0A914IER7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IER7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9222.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9222.t1"/>
        <property type="gene ID" value="Gr19_v10_g9222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9222.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8318" checksum="6D002481BDA2FFED" modified="2023-02-22" version="1">MMVKLAEEVKLAEEVKLAEEMKRMMKLAEEMKRMLVKRRTRLALRFANVQCDPNASRPIRVLLAERPILGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGH9</accession>
    <name>A0A914IGH9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGH9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9665.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9665.t1"/>
        <property type="gene ID" value="Gr19_v10_g9665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9665.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13272" checksum="9B2FD337AF2F88F1" modified="2023-02-22" version="1">MGTLSYLNKCPKRNKRTNKIIMQLSVLFVVLMMLFATFYIGVEPFARQAALNNLAGGDEEPDASVAAAAQPGQQPGQQPGQQPGQQPGQQPGEQPGQQPGEQPGQQPGEQPGQQPGEQPGQQPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR56</accession>
    <name>A0A914GR56_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GR56"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10539.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10539.t1"/>
        <property type="gene ID" value="Gr19_v10_g10539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10539.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18686" checksum="20AFCF7FC6DBFEC8" modified="2023-02-22" version="1">MSFPKLSTTTTEISSLPTTVTSSPPAKFAETKWLGKNKRPPCDENAEKKKKPTKPTGPKEVPPAIKKTKMEDSAVKPQESEPPVEKKRKVEDREIWKLMKGKYLLSFYLCPDDWKKLYNRENKVVRQENGHFAARFELCADCAWANVRATDYLAPPKNKKMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRQ4</accession>
    <name>A0A914GRQ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1618 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRQ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10136.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10136.t1"/>
        <property type="gene ID" value="Gr19_v10_g10136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10136.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35632" checksum="536EEE015222B184" modified="2023-02-22" version="1">MSDNKSNKEQQQQMEEIFICADVWLEVFAFLCPFDVGLKMALISDRLDVLVDVHFKSREWSLGSMEILRAKPSKCSLSNWGLRIRRATDGNGAQIVNKRSGERLPIPQEPIPKNVIGFNRIEISYVDQTVIEFLQRILFDSSGTNVWIHTSVDQSRSWEIIWENIWPLVNDNICGLSLESSQLNHLRQFSPAILRNCTNLRSIAAAKWLLTPRGDGLPKMLICDFYMGGMEGLKEAINLSFVNASEPANFIFSFWYDEDDDFVPFELKNALTRERLTFRQIDKDNWLLTKTSSLDMDRDEVRTAELGPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTC1</accession>
    <name>A0A914GTC1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTC1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10563.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10563.t1"/>
        <property type="gene ID" value="Gr19_v10_g10563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10563.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="44829" checksum="55AD84A7322D4D3B" modified="2023-02-22" version="1">MDKDNKLKRINAFNAAVAAYVRSAAGQSALAGLARATIRFEERRARYGQFPAGAADASGPPRGPVWPPVKAFSAAELIPFHNNAAFLHRVAANWRQTILEGHRNDAIGQAAYQAAFHGEYVPLTDAEYRAAMGMPRHAAPVLVDRHLPVLPVDGGAVQPAEHHAPASSLAQPSVIPAATATRRRHPNETIGTLGPSAPQRRRALSTDQQFERIKEGLIDIVARIAHLQSQHHNQPSTSQDRRRSKSPDFLFHRTPSPPFHLAAPHLQAWVPTQQEVQEGLAVANLFEEGMATANIESTGGHLPAAVSVDNVRQVQQAVIGSGNLRGLLGPPDPSRALRDRSLNRHVVVQRRAPSLQPLVAYVATDTIRAFWRLAGASGTADITEQQQQFATVTGSTGTADTTERQRQQFAKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTE4</accession>
    <name>A0A914GTE4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTE4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11191.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11191.t1"/>
        <property type="gene ID" value="Gr19_v10_g11191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11191.t1"/>
        </source>
    </evidence>
    <sequence length="606" mass="62313" checksum="F62CF289A2D13087" modified="2023-02-22" version="1">MEQLIQQQQRTDDASAPMEWKDPLQMLAKQCDTISGGAEEGRAMGRVRGEGGMETGDGVQQQQAAPAAGKGTTRKSAVVGTNNGTVQQQQQHRKSSGDPHFGDATPKMTTQQKATGNKAKSPNKDLCSSSPSTAAFLHAPPPAAFLHGAAFAPPPAQLAAAMMAGGFFGFPPPPAHRPPPLQQFPPASAIGMPNGQSPPLALNNAMHQLMNAAMQQQMTQQVLQPQTFNSPAGVHLPPSMVLKKMDDPSFNMAMAMLPVGVFPAGGPFLPPNGGPSMSNGGEGLSASPSSTLSIPALLMACASGQLPQGCLACTYRLKDGQLCGCVFPTEEQLFAHYKSAHIGKQSSPNVVSSTTSQGEQSVGTTTLFATSTSSATSAGKKGPAGSPSSSRSTPTQQTSRVSQSGGTETAMVKSHSNPGAMFCNNGTGWSSVGVPLGVCPMGPPMPLQQTGLTAQQWKEAISLTSQPQSGGANANHRFHPYAQPSGKLGLQTGQQGQQTPTFQQMAMAINNLGLMANLGALPAGFFPAGADFVMLAQQQLGLNCPPPVGVPTATPPATSAHHQQSQLAALAAMANSIGSGGRTSTGTTARRQQQTDGVTPLEAVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVR9</accession>
    <name>A0A914GVR9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVR9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11222.t3">
        <property type="protein sequence ID" value="Gr19_v10_g11222.t3"/>
        <property type="gene ID" value="Gr19_v10_g11222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11222.t3"/>
        </source>
    </evidence>
    <sequence length="121" mass="13058" checksum="E88FE6807FC2729C" modified="2023-02-22" version="1">MQRSIDAAIFLANSISEAESKICYSGGSKLQCIKSDLQHTQNQSISTQNQPHSVPMAIAAKVLVLLFFVLALAFLVEQTTAQWYGYPYYYGKREAGFMPQGAANGNAEGSAAGGGHAMFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYQ5</accession>
    <name>A0A914GYQ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11624.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11624.t1"/>
        <property type="gene ID" value="Gr19_v10_g11624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11624.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38539" checksum="0099C1C07565165E" modified="2023-02-22" version="1">MSDNASKAKKPLKEILICADIWFDVFAFCGHFMLGLKAARLSDRFDRLVDEHFKTKERALGRLVVRRARHGHGAEIVKFIDCKRKRSLLFPQEALPAKVVGFEHLMISYIDQSTVEFLQSIRRLFASTGSNLSIGTFDDQTRSWQIIWARIWPLVNANICGLQLSTANFNNLPASRRPFCALPADDSADASSAQALAKWLHTPRGDGLPKVLKCQHYLSGPEMEEFRTEFVHSTEPVNFIVVLDFGFGVAPFALVNNVTGEQLAWRRFDNNNKKWLLVRCPAERDEEQWAELEREAIEWNWCQWNHFNINFQDRDIGRGLHDANDGGPSEPKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZN2</accession>
    <name>A0A914GZN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11874.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11874.t1"/>
        <property type="gene ID" value="Gr19_v10_g11874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11874.t1"/>
        </source>
    </evidence>
    <sequence length="862" mass="92770" checksum="7CE913A4C08C116B" modified="2023-02-22" version="1">MFAPSGSSELNEKHHDLKVYITTVTGNSEMRKQVQRILMTLDALSVPFHAVDITVRGNEHERDFMREKAAGNPRNVSDVPLPPQIFFKTDYLGNYTDFDEAVESNRLEEFLRLLPPEDLLLDEEDQQEDLEDESESDFDEEEETEDEEGGPLDGGRDVAISEKIMLPNAHVNDVTAEEKSKAKEQKEKPKNKTAEKESKQQNGEEKKKAGAKKEEKKSAETKKVAEKANPKKEEKKAVEAKKEEKKAVEAKKEEKKAVEAKKEEKKAVEAKKEEKKAVEAKKEEKKAVEAKKKEKKVVEAKKEEKKAVGTKKEETKEEKAKKEDKKGLDTKKENKLAETKKEEKKEEKKEEVVEDEEEWTYEEVTDYEEDEEEEPKPSTAAKKEDTVAQKGTVPKTEDKLKRTQSPEKKKEETVKRTQSPEKKKEETVKRTQSPEKKKEETVKRTQSPEKKKEETVKRTQSPEKKKSELEVAKKVANKQELEDDEWSYEYVTESEDEEEPVPPKATTKASPAATPAKAPAATKAPTKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATKAPTKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAATPAKAPAVTPAKAPAATPAKAPAATPAKAPAATKAPEAVATKSAVSKSEVQAKTASSKRTASPSKKPTETVKSPTAQPVSATTAPASAKLTESSKKPEMNKKPEAEKKPESKKTDVTKLKTETIKAKQEIAVPKKPEMEKPKLEQYNNHVSVEEDEWSYEYVTDSEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H062</accession>
    <name>A0A914H062_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Target of Myb protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H062"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1272.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1272.t1"/>
        <property type="gene ID" value="Gr19_v10_g1272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03565">
        <property type="entry name" value="VHS_Tom1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF137">
        <property type="entry name" value="GH05942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="93"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="4">
        <location>
            <begin position="280"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1272.t1"/>
        </source>
    </evidence>
    <sequence length="523" mass="57927" checksum="761371C4264EE7C1" modified="2023-02-22" version="1">MAQLTGVDVRSLSIIFFLLPKSILPKPNTIHTISSPLRPLFFLLKWPIVRREQMANAMERVGEAAQSVGQRVTDFFQGDPFGTLVGRKIELATDATKLATENWGLNMEICDFINGTNDGPRDAVRAIKKRLQTQMGKNNAIVMYTLTVLETCVKNCDQRFAVLVTNREFVGELVKMISTKHDAPQIVQERVLSIIQSWADAFRDDPPLSGVVELYDEFRAKGVEFPATNIDAMAPIITPKQTVFPSVIDQQQRGNAKVATQTFPLPSEQPLAQPQSQQQQQFVNNGSVELDLVQVNLTVLRELVAQMKPTNEGTETEAPDDFHFIRELYSTCKEMQKRVLELIPSVTNEEVIFELLSVNDELNSTFEKYDRCMTNYNAKGVDLSMVASGSGTKQHKDNGGAAGDELLIDLAEEGTEAKSIVDKMRQIDIQNDGGRGELSTAKGGGVAGMSNEAYVHDQAELPIRSVAYNKTDATTEKDGERAAELPKKKPGGVGKAFRNWSFSCQSVDKPPPPTFTPPTHFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H269</accession>
    <name>A0A914H269_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914H269"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12547.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12547.t1"/>
        <property type="gene ID" value="Gr19_v10_g12547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF68">
        <property type="entry name" value="GLYCEROL KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="8">
        <location>
            <begin position="295"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12547.t1"/>
        </source>
    </evidence>
    <sequence length="550" mass="60422" checksum="7BAE0B7D18B25F20" modified="2023-02-22" version="1">MDKPPLLLALDVGTTNLKICVFDASPSAGCALIHGHEEAIQLLCSSDGQRVEMEPEKLWTQIVHGMRRAVADTESKGSVVGIGLSCQRNTFLSWNRQNFRSCHRLITWKDVRARHFCNQWNGSMRRKLLNMAGAVAYFFTRDQHYRAARMFRLVSAMVPPRFLAMLEESAEMRGLLAAGQLEIGCLDTWLMLKLSGREGRRQQHPQQQQQCFITEPSSASSTGMFDPFTSDWGRPILRLLGFPDPCAVLPALAETTRLGLHTDPELFGRAIAICASLGDSQAAAFGAGCIRRGDLKISLGTGTLLDYVSGPDIHSSMKGMYPLVAWRLDGRSTHLLEGRSNDVASAIHWAQSIGLMPAHDAAAPEGDLDGATDDDDDDGSLCFVPAFGGLQTPVGDDFACAALMGIRSITTRRHIVHAVLDSVAFSVYQIWLCLVEEVPAARNGCCRIRCCGGVSRNARICERIATLIGRPVERAREPQFCSARGAALLAGIGAGLWTLDQVDSTAGDQSLVHVERVFHPQMGAAAAALQLRFHRWREAQRRCLHYYKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2Q8</accession>
    <name>A0A914H2Q8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2Q8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13444.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13444.t1"/>
        <property type="gene ID" value="Gr19_v10_g13444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13444.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10465" checksum="DCB202DCA32CE1EF" modified="2023-02-22" version="1">MKPISLGQQSNGKPNSTAVRPPNWPKKSEIVSVDFGAVPFWRPWSLSSRLQISILAKLSTQPTAVVKKIGRSMDSCALGGLSPSSSPSSPQAQCFIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3C8</accession>
    <name>A0A914H3C8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alanine--glyoxylate aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914H3C8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13466.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13466.t1"/>
        <property type="gene ID" value="Gr19_v10_g13466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06451">
        <property type="entry name" value="AGAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF40">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="85"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13466.t1"/>
        </source>
    </evidence>
    <sequence length="436" mass="48056" checksum="D90D3AADD933EDC6" modified="2023-02-22" version="1">MLSRMFSPAGAVTQMCEHNKRLLRKRVSITGLLTRCMANSSFSATVAPPHRLLRPMHINEKKLFGPGPSNMPPLVQEGLIQPLLGHMHPEFFEIMDDVKAGIQYIFQTENALTFAVSGTGHAGMECAILNLLEPGETILVVQNGVWGQRAASLSERLGLKVHRLIVPEGEVINLDDFAEAVDNYRPQVAFVCHGESSTGVVHPLERFGDICKAFDVLFLVDTVASIGGAPFHADALKVDCVYAATQKVLNCPPGLAPISFSSKALEKITNRKTRVPSFYFDALELGNYWGCFNEPRRYHHTAPISLVYALREGLSAVAQEGIGHMVNRHKINAKLFYAALKQLRLELFVEKENNRLPCLTTVRVPDGVDWKAVQDKLMAQGFEIAGGLGPTAGKIWRIGTFGINSNPEDIESLKQALKGALYEDEEETLDHFKAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3S0</accession>
    <name>A0A914H3S0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pepsin inhibitor-3-like repeated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I33 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3S0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13879.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13879.t1"/>
        <property type="gene ID" value="Gr19_v10_g13879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.50">
        <property type="entry name" value="Pepsin inhibitor-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010480">
        <property type="entry name" value="Pepsin-I3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038412">
        <property type="entry name" value="Pepsin-I3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051901">
        <property type="entry name" value="Protease_Inhibitor_I33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37969:SF4">
        <property type="entry name" value="PEPSIN INHIBITOR-3-LIKE REPEATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37969">
        <property type="entry name" value="PROTEIN CBG07421-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06394">
        <property type="entry name" value="Pepsin-I3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55149">
        <property type="entry name" value="Pepsin inhibitor-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037862909" evidence="7">
        <location>
            <begin position="25"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Pepsin inhibitor-3-like repeated" evidence="8">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Pepsin inhibitor-3-like repeated" evidence="8">
        <location>
            <begin position="333"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13879.t1"/>
        </source>
    </evidence>
    <sequence length="438" mass="48555" checksum="A5D436AA97AF61F8" modified="2023-02-22" version="1">MAATYILFLAAVLLFSPLCNSADAFDLLDFACAKSGAKLTSGIAIEENQIRIERAPKLEARAIFVLMMRLNNDQFTMTFVVKPSCTAPFKNSTNCRLTEENVLRSEHLSNECPTSGPCKAFKLHCNFKIQKFYNVPPGARVFKIEMSLFTKLAGKECKGGFAYIDDALALIAQSDANGEQCPTDPTTVFELCMETWLGFHSLAICAMPFIIVWSYFKYPSLFDSRAIVQKTSCDRMAQKICGVFFLFPFFALLINAQYYSPPMMTGSGCVATGNKLYSHGNFIRELSAKELTEMEKYKRVLVEWKQKVDEAYASLEQAVQQNATTLPTIPARPQLPTFCTSNQTTLYILAGCTVQNHKVYISGKFARELAEKEKAQLDEFARQMLAQQNQQLQQSQTTNGTATAPPAAAAAAAAASTTTVSPMNDIGRQIALDFCMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4A9</accession>
    <name>A0A914H4A9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914H4A9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13719.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13719.t1"/>
        <property type="gene ID" value="Gr19_v10_g13719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="306"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="878"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13719.t1"/>
        </source>
    </evidence>
    <sequence length="903" mass="102393" checksum="5C775509D422F247" modified="2023-02-22" version="1">MLENAVLYFPDFEAARNDQKRPFIIMTDASKIGIAAILCQQDPQNNIRPIYFASRQCNVHESRYSATELEALSIRFGVKKFAQFITMIPTRVITDHKALIWMFRSKKETGNARIDRWLLEICSKFILKVEYQPGKKNVVADILSSSRALEGNQMPEPEQEEEVAFIRKIGVNAIAEGREEWDENREEWIEETRQSEMQSVYEFLEHRTMSNDPRERQKVLDTCHKYTIFENLLYLSDEKGKLRLFVPSKFRKKLVSQRHEGKCAGHMCGKKLFAQLGTEYVWPNMLRDCIQAHLNCRICAHTRNARANDAVAKIFVEKFTLVFGTPAKIHSDRGKEFLNATMEEIGKILGIKRSFTADYDPQCNGLAERINRILIGILKKSTSSNWTWDERLAYAVFSYNITPSNTTGFAPFTLMFGRHARFPLDEVKPLPVNPIYTIDSDNYQQLFRENLLNMLEEARKNAEDAKAKGKEWYDALSKVKAEKFEKEQMEVEERAPAGFNWTSTCSNDDPEHEMCGSINLGELDPIPGINPQLEGILVKTPLQALLVVFLMRSGVASSMSAAQNMVKTIVEGEAKLELILYSGRRGDQISTGNYPSEEDQKKALEGWVGNCDKARQALAKTKFELLAMDIPEGVAALPEAERKGWRAVFERSAWVLEEVRAMRIHKAERFISHQRVILGDSSARKLAEYIEQSACIGDRGPVADVIRAFKPVVLSSRVKALLVIVGRDSLVNGETVEAMFEQLKLLAGLCKRFRHLVEKMRAIEEPPAISLVSTTPTGRSALEIFRFGDSHNGYLIDEEGTLKNAGVRALKAWIYSQTAFPGDETLHIRSVHSVVTVPGGNRADFSPAVSHSVRVQAESRQNAGGKLQSARHHPYRPIQPLQGRHFAGSHRRDAPPDFRPFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4Z9</accession>
    <name>A0A914H4Z9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H4Z9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13880.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13880.t1"/>
        <property type="gene ID" value="Gr19_v10_g13880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000055">
        <property type="entry name" value="5-methylcytosine rRNA methyltransferase NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="13">
        <location>
            <begin position="173"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13880.t1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55532" checksum="F607E3B7E21C135F" modified="2023-02-22" version="1">MYEFLRILRFHSAQLEQRVSKSGSPRFKPKMAKVRPLRTPTMLALDNFDFYYGPIFGEKWPSIRLGLLTRKKFVAVLNRFSTKFEVNKEILKSLGTVNLMESMQISEETSNRLVKRKREMDRKAAQSHANDDDNSQSEEEAEDGLSDEQDRSEEDIASRLDIGMEMFQPSTKVIDHGREESKRWRRIRNRDKGALEMLTSKRVINDSNFKVTGLEGVDETLPMVEDVLVYPHNLELFAHPRMCIDGFPEPLKDRNNISSWWLLDGGSVLPVLALDLRDDDVVLDMCASPGGKSLLILQTGKFASLVCNDHSLFRLGQLRRALALHVPANSEVSSQVILKRKDASSVEAWTDTDIYDKVLLDASCTTDRRAVTVDDGNIFAATMTGERLDLPQLQTKMMVNALRSVRVGGSVVYSTCTLSPTQNEIVVENACALAGTHYGIQTVERSLKRMENRLANTGLFQFSADCRRGSLLLPNLLSNYGPTYVCKISRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5F2</accession>
    <name>A0A914H5F2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5F2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13403.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13403.t1"/>
        <property type="gene ID" value="Gr19_v10_g13403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000038">
        <property type="entry name" value="Glutamate-gated chloride channel alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038165547" evidence="11">
        <location>
            <begin position="36"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="209"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13403.t1"/>
        </source>
    </evidence>
    <sequence length="540" mass="61989" checksum="0BD202151CAA339B" modified="2023-02-22" version="1">MSSRHPFFGQFLSAHRPPPALFFVVFFLLPSPLLPLSSRTSVERSQLLSRRHTAISSLAGRKELRPSPPPQSVPINPTAQPSNSSSNSPSNSLEEEQNIIQRLLHNWRVRPRGTMAALRGNHWSGDFDMPVMVDVNMYLRSISKVDDVNMEFTMHFTFRQEWTDERLFFHSHSLAYIVLISSEYSQRIFLPDTFFQNEKDGKKHDVDKPNVFIRVYNGTGRVLYSSRMTLTLSCPMHLQAYPLDTQTCFIDYASYAYTTKDLEYRWKADDPIQIKHGMRQSLPSFVLSAVTTANCTSVTNTGTYSCLRTIIRLRREFSYYLLQLYVPSFMLVAVSTVSFWLDKDSVPARITLGTTVLLTVTTMASGINAKLPPVSYTKSVDIWIGVCTGFIFAALLEFSLVNWAARKEASSMAKSNRRKTNPLLSAIHHHREHQRRLSVMDAAVFGTLRQFRSASAFSTSREADIMNRLRHRSGLSGWWCELWTLRYREKSRRIDLLARVLFPLFFVIFNIIYWTCYLRPYLAEEVEGYIAGEKAIEGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6F3</accession>
    <name>A0A914H6F3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6F3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14438.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14438.t1"/>
        <property type="gene ID" value="Gr19_v10_g14438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="490"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14438.t1"/>
        </source>
    </evidence>
    <sequence length="689" mass="80533" checksum="4E43ED46F5FED66D" modified="2023-02-22" version="1">MSSTDSTNDGGRTADQQEYLPPNFANLHPSEELRLLRAQIAQLERQQTMNSSTSSSAGFDLVAQNKNEFGNADDTLGNRNKIEEEKNDGGKEARIAEFARCREKITKIELELNEVNEELKNAKELLGKNHKQMEGWKSRVDQMALLERLKGLEQNQIANSEQIDQGMNQLKRELSAKIEQYQKQKMEEDLVAQNAKRRRIVRDVGVNEEHEELVGRRPEQMEEWKRIAKLELENKELRTELEHKKLLIAHNALQTKMEQYQRQHQQTIDELTEKQKVSIDQFSLLQGDQNALLDRLNALEQKQTANSKQQKALSATIDQGINQLNGELIAKMVEYKKEQQQKMEEYKKEQQQKMEEYKKEQQQKMEEYKKEQQQNMEEYKKEQQQKMEEYKKEQQQKMEEYKKEQQQKMEEYKKEQQQNMEEYKKEQQQKMEEYKKEQQQKMEEYKKDQQQKMEEYKKEQQQKMEEYKKDQQQKMEEYKKEQQQKMEDYQKLNIDALIEAESGNGLTPQNRWDPAECGEDLTLIEPDRLIVQNNGKDGEDCSVLAERPIPKGRFGIFYYEVTILVEDDVILIGLGAKQMPLNEPVGHQKGTYAYASCGIYCGHAVEGCSHLANGHPVIKGKPKFGGGDVIGCGVNLATRQIIYTKNGRRLKTIGLFVADSDAELFPWVSLSNSGDKIEANFGPNFEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H768</accession>
    <name>A0A914H768_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polymerase nucleotidyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H768"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14828.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14828.t1"/>
        <property type="gene ID" value="Gr19_v10_g14828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14828.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27421" checksum="DC0B27F2AA446BCA" modified="2023-02-22" version="1">MLCPLISYQHFINALASRTLDEMLWQMPYFCFPKSIKQNMLEQQGHLAVRPWTTSWPCFAELQHFISFNDFCDELKLYELYRAFVLSPSDEKLLILEIGSIIVEIKQRLKAIEQLENSGKKARLLISGSLLLGTHTYDSDVDLICIVPGKSIKQTHFFGKLDTACCNQNKCSEESNSSSLYCRLCENKKVTELVQITYGTIFMLKFKFDGIPVDIPLKKTINSTKKFAPFQVIVRHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8D3</accession>
    <name>A0A914H8D3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8D3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1516.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1516.t1"/>
        <property type="gene ID" value="Gr19_v10_g1516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491">
        <property type="entry name" value="A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491:SF82">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1516.t1"/>
        </source>
    </evidence>
    <sequence length="866" mass="99475" checksum="C08CAE5272DB8490" modified="2023-02-22" version="1">MPKDTGGAGAVPSPRRNRKGKEEEEGRRRRREGGGGGKEEEEGRRRRREGGGGGKEEEEGRRRRREGGGGGKEEEEGRRRRKEEEGGRRRRGEGGGGGKEEEEGRRRRGEGGGGGKEEEGEGGGGGKEEEEGRRRRREGGGGGKEEEEGRRRRREGGGGGKEEEEGRRRRREGGGGGKEEEGGRRRRGGRRRRGEGGGGGEGGGGGKEEEGGRRRRREGGGGGKEEEEGRRRRGEGGGGGKEEEGEGGGGGKEEEGGKEEEEGRRRREGGGGGKEEEEGRRRRREGGGGGKEEEEGRRRRREGGGGGKEEEEGRRRRGKEEEEGRRRRREGGGGGKEEEEGRRRRREGGGGGKEEEEGRRRRREGGGGGKEEEKWRRSCGRFKWWWWWKRGFKKGKEEGKEGKEGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGRGGKRRKRRKRRKRRKRKEEEEEEEEEEEEEEEEEEEEGGGRGGKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKRRKEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEERRGMDKAITAKGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H934</accession>
    <name>A0A914H934_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H934"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15345.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15345.t1"/>
        <property type="gene ID" value="Gr19_v10_g15345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000222">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15345.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8346" checksum="BDC327CDAAFD45F7" modified="2023-02-22" version="1">MQIFVKDLYGKTTSLKVEAGNTVADVKEMIEAKTRIPTGQQRLIFNGKQLEVDRTLAACNVQDGSTFTLILCLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAA7</accession>
    <name>A0A914HAA7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAA7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15240.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15240.t1"/>
        <property type="gene ID" value="Gr19_v10_g15240"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g15242.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15242.t1"/>
        <property type="gene ID" value="Gr19_v10_g15242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15240.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15242.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8820" checksum="2E4E56F103046226" modified="2023-02-22" version="1">MSITKSTDRTPKLDKLNPIQLISLDKLNPIQLISLDKLNPIQLISLDKLNPIQLISLDKLNPIQLISLDKLNPIQLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAJ0</accession>
    <name>A0A914HAJ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAJ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15311.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15311.t1"/>
        <property type="gene ID" value="Gr19_v10_g15311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038070332" evidence="3">
        <location>
            <begin position="22"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15311.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="35249" checksum="BCD00F416FE7F508" modified="2023-02-22" version="1">MKKFQTIGFLLISKLIELCFGVGDEFLIGPDSPSSDGHNSGQASASSRDSHVEGESIASQISRLNARILTLEREKSQLEELHKLQQKSFDQLYNHWQLEHAQHEAIQAEFQKMQLQQCVQKAIMKKIWSKYDHTNSMVVGETSAPMQRSDDMDELVITEGFMQDNFVQFLLNEFEQYSVRFSKIVVTSNVHYEPNAIFKAIKQNLLIDRPDHQFDRMRFQINGIASKERQLFKSLQKARAQSPRSPQIPNVNILYDGERNAWQLWNHETMANFRLRVVGHVQEKYVMEELFDELELVKMDPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAR6</accession>
    <name>A0A914HAR6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAR6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14856.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14856.t1"/>
        <property type="gene ID" value="Gr19_v10_g14856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14856.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27202" checksum="4D1EA2CDC7E0D913" modified="2023-02-22" version="1">MAINMSDKKSLVNQIIGQADITVTTSGITLSGPRLSTPRFIPFDESGRCRSCKATEVEVDTMTTKEGITLWCTRIDKTQFIPFDVVYDLPGHCFFRVKNKARVFNVQYSDIPSDTCDIQLGHQDDDDDERALKRKAKVALDLVEQGLIADAMQDNMRWKKAKAAFNVLGNLLLTESIDNSKKTSGPVNGPQQLIFKEGEQQQEGEEVNKQEEGKTYEKDGDNGEIDKTLDEFFSSIKASTTMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBR7</accession>
    <name>A0A914HBR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBR7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15647.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15647.t1"/>
        <property type="gene ID" value="Gr19_v10_g15647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15647.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15308" checksum="C1EB9D9EA7A5C63C" modified="2023-02-22" version="1">MEKTIATVKAFLPAMIEQQRGHIVNVASLAWVAGINGLVDYCASKFGTVGFSEALRLELIELGVPITVTTVCTYYINTGMFDGVRELYTRCSLMRMNFFLPWTANVVATFKGFTARAVYAIAGFFGFNRTMETYTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBS3</accession>
    <name>A0A914HBS3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBS3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1606.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1606.t1"/>
        <property type="gene ID" value="Gr19_v10_g1606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1606.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="56105" checksum="418EC6CA28CCD973" modified="2023-02-22" version="1">MNFGLLNEMSTYAKNRPRRRVKVILVFERLTVTYLKFLFVYATSIHPFGEKWPLPLFRNANDIVLALHNFELDVGRTIHAFCEGGAEVALGDWERTGAGKKRTQKKKSKGVVSSLHSQPKETSGTTTPSVASLNCSNVSPVNFADKLTNGSTNAVDQATTAALKLNKLDLRNDEIGHSEKSLAAQQHQFVHLGEFAAKVGRQSMVINSSTPMDIGNRRTGDVDDSFGLADYQSQLAQNREMFEREVTSAEEAIYQCFKELRELLSCREQRLLGELTQCRKDGLIYFDSRNNILRTLIADCVNPNNKSFMTNLEKFNDKKTEDLEVALTARFLHDNSTLTTSIGQLGKVPSVKSDEAVTLTNGEKNGGEPSSKVSVPAPQPPRTENVVKRSNSPSSLVSSVGEDSGLGGQISPVNHVEKRSAVQVEENGIVLKSDSVSADQLAEIQRQIAESLKAKGIDPSVLANFGSTTVARRRPPNQQTAKNGASTVEKTGKVGAGGQRKQQQMNGVEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCS7</accession>
    <name>A0A914HCS7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCS7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15924.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15924.t1"/>
        <property type="gene ID" value="Gr19_v10_g15924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15924.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="41677" checksum="735352208E9B1515" modified="2023-02-22" version="1">MDRRMQKRRKGCRGATRSRTVPSLSRPNHSWEGEEVEVNKLKEEVTKKKKKEKIEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEERKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRKRRRRKEEEKERKKKRRGRRKGEEEEKERKKKRRGRRRGESFELKHPDAMMTMWLEDRRGRVEFCTCNNAGPPRRKQTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD89</accession>
    <name>A0A914HD89_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD89"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15554.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15554.t2"/>
        <property type="gene ID" value="Gr19_v10_g15554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="130"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="411"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15554.t2"/>
        </source>
    </evidence>
    <sequence length="496" mass="52834" checksum="21AE26AF9532515F" modified="2023-02-22" version="1">MSDDLKFDDTDGSIIGQKRQNPENGGPASKKANVGDSDNLQIKVLIPSAAVGALIGKGGETMRNLKNDSGCRVQMSKNQEVYHGTSERICLVKGKLASTMIVMGAILEKIQEKIDANHAADHFDLKGLDRTKEMKFVVPNTSAGMVIGKNGASIKEIRDTTTANIQIFPKAGSEEAKISAERVITVGHESNDVLLSAVQRVLEKVVADPMHAQPISSETQTSSGFDFSGSRVSTGSSQFGGISNLVNSSDSLHGKAFGGSSYKFNPLQGTGNNELLSFLDNLQSTLRSSGFNDQSVSEVMQAMQVLAKYNIMGLGLGLGVAAMAQMRNTESAMAPQNVLLNASNSLVQQQRYEMMSQSNFAGSILESKPNIDQSIVGGSGGVLIDVMSQKKTGSNGGNSFANSVIKERIVEDGHTELEVPDNIIGAVLGPRATTLIEIQQLSGCKIEVHKRGSNTASPGGRVVSLTGDNNSIMNGRIMIEKVINQEQQRRSMLGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDD9</accession>
    <name>A0A914HDD9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDD9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15993.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15993.t1"/>
        <property type="gene ID" value="Gr19_v10_g15993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="123"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15993.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36337" checksum="3AA477B4FAD0C6C7" modified="2023-02-22" version="1">MIVLSCKEPKGDVPEEFLQIDQQLLCDILGRDELMINEEIAIWNAALRWVDEKCHQNGEELSAANRRAMLGPALFKIRFPLIPKEDFSENIVPSGVLTLNQMMSVLLYHSHPNAGLPEQYPLQFSTKRRTATKSAVDGLTLQNRWDSAACHQDLTIIGPGQLIVQNNRGDLGYRTVLAERPIPKNPFGSFYYEVTILEEEDLLHIGLATKQMPLNRWVGSDEGTYCYERCGKFWGHEVGGCCHNGDGRPFIGGKPSFGVSDVIGCGMDLATRQIIYTKNGQRLETAAFFVDSAADLFPCVTLYYPGTKIEANFGPNFKFNIAADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF85</accession>
    <name>A0A914HF85_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF85"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16070.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16070.t2"/>
        <property type="gene ID" value="Gr19_v10_g16070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16070.t2"/>
        </source>
    </evidence>
    <sequence length="279" mass="31196" checksum="5F336A0C4B4C22C9" modified="2023-02-22" version="1">MMSGIRCRRALCPPVGVFVLTTLFIVTLSLPGTGKARPMRMQLMRMDAQKFDEMLRYLQVEESNEKTVVEDDKMEEASKASSPPPMLPLEEKSAEWNSVDLSSPFHSKESTIKKSEQYNNNDNKIMHFCENSAERRQWEMKVRHFLHSQFQHIWSDHFGVEVLGIKLNVHSIRIRHIHLPKIRVETSCATFVSGGDLQTPTKVTVSGGSLSLLAEYRSTYRTVRAGHLRAAIAAGNGRSGGRASPRACSAFALRTFGPFYSIGTPKMAALINAGRRVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFA7</accession>
    <name>A0A914HFA7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFA7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16085.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16085.t1"/>
        <property type="gene ID" value="Gr19_v10_g16085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037572423" evidence="2">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16085.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12025" checksum="1D6EAAFB59FB3656" modified="2023-02-22" version="1">MKVQCILCLFILSELFVVPALVHAKPVNEKKLVEKRSTGGDLARAAVLGAVSAVAYTAAAKGINKISQKLHGGGGRQQNSEQYQQQQQQHQPPPMDGGGGAGYQQQRGHENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFH0</accession>
    <name>A0A914HFH0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-lactate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HFH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16879.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16879.t1"/>
        <property type="gene ID" value="Gr19_v10_g16879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036471">
        <property type="term" value="P:cellular response to glyoxal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046295">
        <property type="term" value="P:glycolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902176">
        <property type="term" value="P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000022">
        <property type="entry name" value="protein deglycase DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="5">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16879.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="19261" checksum="BB12E39C9D12CB55" modified="2023-02-22" version="1">MAKSVLIIASDGSEDIELIVTSDVLRRAGVDVTIAGLQDQPQIELARKAKLHVDALFKDVLSEQYAAVVLPGGQPGSNNLAADERVGQVLRRHEAAGAIVAAICAAPIALVAHGVAKGGTLTAYPAVKDKITAGGYTYSEDNVCVYNNVVTSRGPGTAFDFALKLAELLAGAEKAQEVRGALLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGF6</accession>
    <name>A0A914HGF6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-type proton ATPase 21 kDa proteolipid subunit c''</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17271.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17271.t1"/>
        <property type="gene ID" value="Gr19_v10_g17271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="53"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="140"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17271.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="21649" checksum="7515BAA90C4737C5" modified="2023-02-22" version="1">MASPTLQTFYALLASGTSILTFMAFYYMLTGQGDRFDIAWFLTETSPYMWAGIGIAASLSLSVIGAGWGIFTTGSSILGGGVKAPRIRTKNLVSIIFCEAVAIFGIIMAFVFAGKLGKFTRETATQDVIVKNLAAGYAIFGGGLTVGFSNLVCGLAVGIVGSGAALADAANPVLFVKILIIEIFASAIGLFGMIIGIVQTNKFNIGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGL4</accession>
    <name>A0A914HGL4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16989.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16989.t1"/>
        <property type="gene ID" value="Gr19_v10_g16989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16989.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8805" checksum="0844C0490CEB6960" modified="2023-02-22" version="1">MGVDADEANDGTNWVESHPCRCGAKNWTASHMERVLVKLCCGSDAQSVIYNANAEKKEEHRNSLVPPEPSGKPFFYLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHF5</accession>
    <name>A0A914HHF5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphopantothenoylcysteine decarboxylase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CoaC</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glutathione = L-cysteinylglycine + 5-oxo-L-proline</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17532.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17532.t2"/>
        <property type="gene ID" value="Gr19_v10_g17532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000004">
        <property type="entry name" value="Phosphopantothenoylcysteine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="10">
        <location>
            <begin position="62"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17532.t2"/>
        </source>
    </evidence>
    <sequence length="440" mass="50157" checksum="7CB55879E40D7C53" modified="2023-02-22" version="1">MASPSNTDNEEIPQKRKRVNDDSGATTTAENNGAERAKVTAVSHRAPFDASHRISRLGGKFHVLLALTGSVATIKIEELIAELHKQSPANRLAIKVIATQSALNFFDASDVQETIYDDRDEWNMWKKRGDPVLHIELRKWADSLLIAPLDANTLAKVANGICDNLVTSVVRAWDQRKPLYFAPAMNTAMWDNPLTYQHMKTLKELLLYREIPTIEKELMCGDKGYGAMASVQMIASIIALSSASQLELRCQMYIFGYGSLLWNPNFPYDEAIRGVVVGYVRRFCQLSPDHRGTPDNVLFILNPDKAVENTLKYLDHREKAGYRLKRVKFYPDDGSEPFELSVYISEADRRNIYHSGPTGVDDIVKQIIRSRGRSGSNLEYALRLADCQRRMAPNFWDEHLFEIEAKLLRECEYLRHEDEILEKLNYNLSYLAKKRNKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHJ6</accession>
    <name>A0A914HHJ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHJ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17418.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17418.t1"/>
        <property type="gene ID" value="Gr19_v10_g17418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17418.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11307" checksum="2F2A1BCB4186DCE6" modified="2023-02-22" version="1">MPGCGWETKDGRADMTNFEMDLFDTRVYRRDDKDESDECCRNSIIKPACFPITILALLLLMTFFVPMLNEDMGDSAVSSTKKYERTGTCTDECRQVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHM1</accession>
    <name>A0A914HHM1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M41 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHM1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17589.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17589.t1"/>
        <property type="gene ID" value="Gr19_v10_g17589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M41" evidence="1">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17589.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15485" checksum="C40D1CFEDE1ADD15" modified="2023-02-22" version="1">MARPNARQRAARLRARQEAEFKRLERLALVWDPAYNKCRVSIHETGHCFLLWNQRAAGVLESTTVVPAVTTDGLTRSEWPWQLTRAQLTARLRVQLGGRCAEEIAFGGVSMGHGTPEAIWHVDGVFWKLCTLVRMAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI25</accession>
    <name>A0A914HI25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17121.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17121.t1"/>
        <property type="gene ID" value="Gr19_v10_g17121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17121.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16116" checksum="417A88DA354EEB5A" modified="2023-02-22" version="1">MCCDATPTAEGRKNATLYLKVRMDKRTINYRSKRNSFGARDAMIRQFILQNLHIEQLSQRALPEPSKQGRANLFRASASLSDRPGPKALRLIRLHSEQQLEAVHGNRKSTYKCLRPHSFGFGIKSDRSSITSTNQPTWQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIZ1</accession>
    <name>A0A914HIZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17817.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17817.t1"/>
        <property type="gene ID" value="Gr19_v10_g17817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="145"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17817.t1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58626" checksum="7579847FBA556F29" modified="2023-02-22" version="1">MTSSAGLLSSPHHHRIIYTNRSRRRWAHALDPFLAAGVAAPSLRRAAAVAPRVGTLAAARSATFRRKAPLPMPIALNQAPPCHYYVFRRAFIRLRARLSSVVSKFLQELQEVQEEKAMLQAPTAPVDASKFVAYVQERRKKRILFKGEFLMIQRSVDPQRCTTEVGVRMGERNQYPDTLPYDHNRVVLELRPGVDDSHYINASYVNSWLREKAYVVTQSVRSKQASNELWRTVWELGANTMVMLTKIFDFMRVMCLQYWPQTHFQFGEIHVETMETQTYAHFVIRTFRLRKTYGPEASADGTAAGATAPCEEQRIVKHFHFTEWELNSFPYISAFIELRRRVRQWMEKSPVDAPIVVHCSHRMPARHVASHIVGSVQLCALLFCPQISRRQERGIARQKMPPGRALVVAEQVAQPCEYLNSAHWATNEADCWQEDTAVQDVHPHGMHFAVQVECECTPGRTTAGRIARRRTGAATAALRARSSPSARSTGKEIDQTDHDQEFERFISFSLEKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ06</accession>
    <name>A0A914HJ06_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ06"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1902.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1902.t1"/>
        <property type="gene ID" value="Gr19_v10_g1902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037043664" evidence="1">
        <location>
            <begin position="28"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1902.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33561" checksum="0513AD7587F586F1" modified="2023-02-22" version="1">MKVFALIMLRCTLIMLWFSLVQNGTLATLAKWETSFRSLVDGIFTAAETPLDKFITKRIRTEFNTFMFELQLELIKVNWTSGNKKELAVKLLNLAKSSTNSYIDVACFVKEWQQIPGSTAKPGTPEFVDFVESLILNAKLKILETELRAKIAGFVPQQPFIDGDAFIELSERFIDEWNEIQQNINKLTNKNTLRKKLNDLAEIAMNETAPLKSIMTKKLGQLITKCQNVEQIKNIASSEIPIISESKFSGAVYDELSNFDEAIHNANFCAELETAVEKDKEMVATAYQVKKNLVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ77</accession>
    <name>A0A914HJ77_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ77"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1809.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1809.t1"/>
        <property type="gene ID" value="Gr19_v10_g1809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1809.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15941" checksum="28CEBD26AF3F4707" modified="2023-02-22" version="1">MYLGHNLVGFGKWPLLPHTFTNYELGPFTVENFNQYSVATTDGAGACANKFAVLLFLDSSRLPGHISIDQGRDILCRIIEHDATLLGCGAKSWEVFRNDNEVDYDVVFIFFASPVGITKIGNGLSAVLRELKMVLDNIAISCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJK3</accession>
    <name>A0A914HJK3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cell differentiation protein RQCD1 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HJK3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17219.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17219.t1"/>
        <property type="gene ID" value="Gr19_v10_g17219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000037">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17219.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35242" checksum="104EBE1DE1572F05" modified="2023-02-22" version="1">MEKLLSPNTASIQSTSTTTTATASSNKDENNKEKDVEQICHWIRELREHEKRENALLQISKRREGVEDLAVWLWYSYGTVSVLLQEIISIYPYILPPTLTAAQSNRVCNALALMQCIASHRNTRKQFLDAKIPLYLYPFLHTTNDSRPFEYLRLTSLGVLGALVKTDEKEVVKFLLSTEIIPLCLRIMEQGTELSRTVATFILQKVLLDDIGLSYVCQTYERFSHVAMVLGKMVIQLSKEPSHRLLKHLIRCYHRLSENNRALQALAQCLPDQLKDETFKNLLDQDRPTKHWWKMLMKNLNIPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJS6</accession>
    <name>A0A914HJS6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJS6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17838.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17838.t1"/>
        <property type="gene ID" value="Gr19_v10_g17838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF17">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17838.t1"/>
        </source>
    </evidence>
    <sequence length="516" mass="55411" checksum="B37F9108B5852123" modified="2023-02-22" version="1">MLSPSCSSPVRCSSSSSTILADSSTLCQKRLLDSTAPNRRPSAGPPTPTWTGSSTTTTATAAAAALARSSSRRRRHSCSQWRSNSYSNTDQCRGLIEATDDGCQAEAGGTAATTPTTILRLRDAMRELARPQMQLCLGSPPSSCNSTLSVATVGVVGQKRRQRRPSGGKHSPTSPPHGALQQQPTLLTLAATGGGATTTRSASVCYLPSAQQISRRCSTTTRSGRLERSNSLVAGRGNATLAFLPELNPQQVANLRRTWKHINTKGLYDIIRRSFRKVESANPSVALAFPAAASETNSAAGDNGNLPQTKYCGVMEHSKYFMVLLNRIIDGDPQEQDLERELKQIGARHVTVYKRFGVGVTAIERTGEALAESLFKLDGIRQSKETTKVWRVLIAKIVDHIESGFTDELRSQRRQTSTALLSSAAGALAAPLFDNKFFKRNSVPSPHNHKSSVRSASNEERDDDNGGSPTTTPASKAPPPPSAVPYQQQQQQSSSSSGSCFLRTELAGVVRRLSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKG7</accession>
    <name>A0A914HKG7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKG7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2309.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2309.t2"/>
        <property type="gene ID" value="Gr19_v10_g2309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2309.t2"/>
        </source>
    </evidence>
    <sequence length="134" mass="14702" checksum="5D6B08FB698E83F0" modified="2023-02-22" version="1">MGIFVCPGFQMQDGALSVAYAVEGVGILTVCYLDHRVLVLLSNALLPLLKRHQFCSDYPVLSNPTGNGHNNSICVLLDDCDFWDFIDANLNALAIERVLSPLCKTDGDCTSTYILTITHRMLVSPQVQARAKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKT0</accession>
    <name>A0A914HKT0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKT0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2396.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2396.t1"/>
        <property type="gene ID" value="Gr19_v10_g2396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="53"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2396.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28648" checksum="BCCB66C1D80F296B" modified="2023-02-22" version="1">MEFLEDDGMPPILDGPFSPARNESLAETNNSDATKVFRLADCLQILESVARDYDCIYPLPKLGRDHHMSGCLLTRSLGSANRMYIFEWEECLELKGHLEMEDGSSKRVLHEFYEKYDGIEGLGRFLRELKISGKEGYIYIGLAQLGKPVGLSKGTYAYASNGYIWGHEAGRYSHAKDGRLFISENPKFGDGNIIGCGVDLEKHQIFYTLNGKRLETPDLRVDSAADLYPCVTWYYPGTKIAANFGPNFYEIADAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKX4</accession>
    <name>A0A914HKX4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKX4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2275.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2275.t1"/>
        <property type="gene ID" value="Gr19_v10_g2275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="1">
        <location>
            <begin position="38"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2275.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22716" checksum="728833D6E70A484A" modified="2023-02-22" version="1">MQQLQKNAIKLRTECQKKRENWKRWIFLDLPEGLYPEYDGATHECRINDALKPYFANICIEYKLHSETGGEPKLQSLDQLKALIEQGIVMAVLKVKRGFREYTLDLDHVYDSKKDRSVYETELHSVLLIGYRSNSQQTHLLIQNPWLLRETVPWGEKGYAWVAVHSITTMELNDQIYTLVVIPPPMNFSSNLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL89</accession>
    <name>A0A914HL89_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HL89"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2171.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2171.t2"/>
        <property type="gene ID" value="Gr19_v10_g2171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="570"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2171.t2"/>
        </source>
    </evidence>
    <sequence length="772" mass="88215" checksum="F1DA4176DDBF949F" modified="2023-02-22" version="1">MKQNANKILALINIHKLDPKNTAELITEHIRIVQNLVGNDLWWHVTQGNLGYSQLDPNHLHQIRTKIGKKASVDAVSRLGEIFKTSEFAFCGSARASAHLRAMFTLPKKLFLAICLIILNVILYMIVVLLEKKNQNLMFSSNTNAFKRWALPAQNAQLDCYCILQGDSEYLTKMAKNRMSCEAIKSRNYFMDEIPDSEDFPLAQARTIYKDYPLLEMELAATYSPQNWYCYVMDTNSNAQFKRQIHALSHCFPNILIGDERQMTSAGEGMTEAYLDCLTRLTEPSRKWKYVSLLQNHDTAIKTRTQIIQILQWMNGTNDAEIMGPGIRMNRDMNWTVSALSFFNNSTKMTELSSQNISLSKGSVAATLSRPMVEYVMRELNLTELVRRLNKVGFGRDELLFPTLNSADIIEAPGGASQICIEKRQQVEQMTRAVVWAQYPKECTSNYLRHGVCVLGMEDLAPNLLCWPHMFANKFLPEFDLGASEIFFWYESLFNRTHLNSREEQLAMLDKEFYAQLPNVRFQKFKKRLTLSRNQSSSKSSVGLSRQYFLINSAFCDILTMNLPTQSTSSDSTDRYKFLPHRTMKNLAQNHWNPNDCHQKLHLIRPDCLKILCLEKNGNDFGGCTVRAKSMLSLHCGLFYYEVKIHQGRDLRIGLATRMMPLDEIVGSCVESFAYDSYGIFRSVGSYHKADKPKFGAGDTIGCGVNLATRQIIYTKNGERLYTANLFARQTDLYPCVTLKDSGDMVEANFGPKFKYKLQHEFAGPNKENIQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLJ2</accession>
    <name>A0A914HLJ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLJ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17743.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17743.t1"/>
        <property type="gene ID" value="Gr19_v10_g17743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39075">
        <property type="entry name" value="FI19908P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39075:SF1">
        <property type="entry name" value="FI19908P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17743.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29780" checksum="4FD88E902F6D26ED" modified="2023-02-22" version="1">MNSINFSTAPPQYEGLKLPLVCVTPFGTISILMAHNINIELSVDRSIRVVCWDKFAVSSSQKSVKSGILHPFGHILQDGDKIGCHFQPQNDPITLAKMAVIGTPGVIFSMSHLKDAFLVSNRGTSALPMDRFQFPTLRYDFTIRQFYANAQMGSEYLLTCNNIVQRARYDEKEGMLFILNINGFLIRQRVNGDVEIFCRPRQIICSPELSTVHLRTANVEMEVQTDKKAYVKYGSKRVHVSRSGMVVSNENCSASMDHIGRIVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNN5</accession>
    <name>A0A914HNN5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNN5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2272.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2272.t1"/>
        <property type="gene ID" value="Gr19_v10_g2272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2272.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39915" checksum="2604BE7865522BC7" modified="2023-02-22" version="1">MSEPPQKAQKYMKQINVCDDVLFDVFGFFGRAEIGLKLALINYRFNALVDDHFLRKKWRIGRMDTICISKCPCMEILRENGTSVKSEFMQMPPKVNLVGSESIVISHFGPKVIEFLHRFLYLINGEISLSLGFHSDAPAWILVPEIWPLLAEKINALGNFSHYRFDLLRQLISPTVLRQCPKLRLIQCQNLFPEATSAADHEHASLGQALSMWLHTARQDGHPKILRYRGVLGVTQKVEELKTNFVNASSPISYVISVEFGLFHGSPFDLTNKRTGERLVLRRHMYLHVNWNRLYTFWMLTRGPNERDEKQWAEWELEAADPFFLGRSLSSADLMLLNTTNMTRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPS6</accession>
    <name>A0A914HPS6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPS6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3101.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3101.t1"/>
        <property type="gene ID" value="Gr19_v10_g3101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="335"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3101.t1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60175" checksum="C14B20B74C2EFCC3" modified="2023-02-22" version="1">MSISSESTDGGDIATDHHDQQENLGPTNLEPFEEMRLLLARIAELKRQMNSPTSSSVELVAQNENEKRPRALSCFMMLIMYRSWRRDFVWRRKNCIRQMRKSTEESFDKKLEEQMEEVKRVAKLENKALRAEHEELSTAHKNLKEEMKEQQKMDALKQQKETNDKIDSLKKDQQEQFANMIRGMEQKQKNEQEALQRNIQAMVVAELEKCQNKQQQTIDALTEKLTGSIDQLSLKNQELSDVHKKLMEEMKKQREMDALKQQTETNDKIDSLIKDQEQYANMIRGMEQKQKDGHEELQRKMDESLKTVEAMVVAELEQQELSNANKFVEIEQKNELNIVHLQKTVATLCDIGLINRWNSAACHPDLALSEPDRLIVQHNGEDWGSVRTEKPLLSKNPYFEVKILEEKGNIFVGLATIQMPLDKAHVGYHEGTYGYLSDGAFWGDEAEGCSRLINGEKPKFGVGDVVGCGVNLGTRQIIYTKNGERLDTANLFVDSAVDLFPCVSLGRPGTKIEANFGPDFKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRE8</accession>
    <name>A0A914HRE8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein quiver</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRE8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3545.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3545.t1"/>
        <property type="gene ID" value="Gr19_v10_g3545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3545.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17854" checksum="42BEDA514D724D0E" modified="2023-02-22" version="1">MISGQRLFYIIMMLIVSSITNNHIIKSSWAISCYDCRSEDISCNVGECVGSTCVKMETSNVDNERKTISKSCNNEFEDNQCKQSYLGLKVVLRCTCDSNFCNGDRNLVAAGLQRMEDNGTTGRRAVPPNGRGLMMAMALFATIGGALFVTVFTSHFATFSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRG3</accession>
    <name>A0A914HRG3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3969.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3969.t1"/>
        <property type="gene ID" value="Gr19_v10_g3969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037011491" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3969.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8629" checksum="3E5BA35E28173B2A" modified="2023-02-22" version="1">MLILCLILFLTLQFPEPIETVVAHAALKLATSPVGEVALNAMVPGAGTVLGVAAKHHKMVKKVVHLLPSSRSFAAKPDWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRI0</accession>
    <name>A0A914HRI0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRI0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3790.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3790.t1"/>
        <property type="gene ID" value="Gr19_v10_g3790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3790.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="18742" checksum="2006A13A22809EE6" modified="2023-02-22" version="1">MGAKGIGVQPDSAMAILSQRNASQRLFYRGDLPYVITGGSERVGKIARAVTGLILVSSTMLNGVGATAAAGNTNVVDHQQALAAKPSWEWKPPALGHLNASHVLQNMDSSEGTGNANNGRKGNSRSVKKAKKPAAVHKISAKTVDATPINRHQNVFGAKAPIVPPETDCIYISLYTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS91</accession>
    <name>A0A914HS91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3995.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3995.t1"/>
        <property type="gene ID" value="Gr19_v10_g3995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3995.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12843" checksum="D3D0E1502E9AE3EE" modified="2023-02-22" version="1">MTKQFDKKHGAKPSEFDPQDPVLLLNFKLGKAHWLPGTIVERVRHSPTYRVLVPSLGKRIVYRHANQLRRRFAFEEDGLQLIVNRFRQFKPTKTISHQSISNCRRAVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT63</accession>
    <name>A0A914HT63_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT63"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4422.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4422.t1"/>
        <property type="gene ID" value="Gr19_v10_g4422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="122"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4422.t1"/>
        </source>
    </evidence>
    <sequence length="344" mass="37630" checksum="295A1DFBDCB3920B" modified="2023-02-22" version="1">MSASSSQPKDQSTSSHKSADQKQLVVVAPGTSVKAANRSVLLCETEVQLEKLALDTQRDQNKKSDACANDGEEVKLFFKLAERGGAAKMRAMLKGPNADVLLSAKVNGFTALSVAVQQGNTEVAELLRAKGVMDVKSPAVTFVLTPQNRWRSDVCFWGGDFKLFEPDRLIVEMTNMLFGGAVVAERPIPKKDSGIFYYEMTILKLEQNAVVHIGLATIRPWNIPFPFLIKQGRPDKFWGYASNGIIVHVNDPLFLWLLWRKENAFSSAESFGVGDVAGCGVDLATRQLIYTKNGARLEIPDLFVSSAGDLFPIAAFLVPGSGFSDGKIEANFGPNFKYKFAVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTL8</accession>
    <name>A0A914HTL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3650.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3650.t2"/>
        <property type="gene ID" value="Gr19_v10_g3650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3650.t2"/>
        </source>
    </evidence>
    <sequence length="275" mass="32399" checksum="A05200DE741D019D" modified="2023-02-22" version="1">MPSLDEIFNLKRVTLHKWKKPFDPILNKNSVDEHSLPENRPSFADNDTSGQPMPSSDENLWAWNLAKKKRTERIEVEYPVENPGGSDYEKSNDFEEKSDALSNEEQQKSEKKIIKKIRSDNEKKKILKKFLAKKERLANEFGSTPKSKLEEIARELGTCFRTIRNWRFKFGMGYKNSKCQSERDYQRENIFKKFDKMKEKRIGKNKFAKRAEIEEEIARELGLSKQTINTWKVKLGQKTFKHYSREEKVLVGQQYGDGNKSLEYQNCFVLPNQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUA0</accession>
    <name>A0A914HUA0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUA0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4251.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4251.t1"/>
        <property type="gene ID" value="Gr19_v10_g4251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036926852" evidence="2">
        <location>
            <begin position="30"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4251.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="23971" checksum="FE0DFC696994508D" modified="2023-02-22" version="1">MAGITLLRAGVQSVLLLITLATVVQRVHGQWVPQQQQQQQQTPQRPLLTSDPLTYGAQRINLGCVVCMNCCCFCTPARPPIPPEQPPLVPLYNQPGGANPAQQQMPLRHSSVPSPYEDGQHFPVQQNAQAGASGVPFVGSPTAGYSNPAAGPIQFAQQRQQMTASGGGGGTLSELPSGEPGFLPNYRGDQYTNAQRSFETREMNGPFFERIGGEPRYSGGDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVS4</accession>
    <name>A0A914HVS4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVS4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4621.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4621.t1"/>
        <property type="gene ID" value="Gr19_v10_g4621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4621.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16949" checksum="13FD80529A9CA05E" modified="2023-02-22" version="1">MAAMAATPIGDEVAHFHFDIFMATRDEPTNTQVFAAQDTTEAMCAVLVSYCTSMNVFAASFRGKKIIWRYAMLVANGTDVNRESLTAADYINKLHFPTVDCQDIEVTHRCNATGLMYASHKRIPRLDQRPRAQAKAAQNPGHPWRVLLLGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW12</accession>
    <name>A0A914HW12_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HW12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5006.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5006.t2"/>
        <property type="gene ID" value="Gr19_v10_g5006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06966">
        <property type="entry name" value="NR_DBD_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000042">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF508">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5006.t2"/>
        </source>
    </evidence>
    <sequence length="1116" mass="120195" checksum="902D36887926524B" modified="2023-02-22" version="1">MVNGGGGGAGTSSMVGGSTPVVEKRPATKICRVCGDKAYSYNFNVITCESCKAFFRRNANKEKEIRCPFNEQCDINILSRRFCQRCRLQKCFKVGMKKEWIMSEEARLEKKQRIQENRERRAAAATGTAEFEPVLFHQDSQMLIVDGGDVPMNELISQQQQQDDVVAPPSVLDIRLPETVAAPISESNMSNAVGGLPSGLLESATAPNPQLALPNPFITSTTAAAPILMGSAASGQSVSTVERQQQQQAIVAQVAAVAQVAAAAQACAVQRAVNQAAAAAVLLHHHQQQQQQFEHPPEPQQQGPLDPSPLYDSVLQPSKQELTAVPPVVGIPVASSTSIHTTMAEGGEPCFVASGEIVQPSTTFGTLLPLPITGQSNSNENVLPSLLPSGVIVSSSTEQNAQQAQNTGVFAPAAAVAAALMQQHQNNSGCAVDPSSTILPAMVAPPAANPSTNLMPSGGGIMSQDIQQQIVSQVVAQQAQLNVQFEQQQQHLINQQQQAVQQHLINQQHQQIATVPQQIHQQQAVQQQQQAVQQQQQQQAVQQQQQQKTAAAQIVAHAQQMVIQQQHLAALANAAAVHHHHQQQTVVAPSTAESVSQQLQHVAAAAAAAHQQQQLTVLPPPANAPAPLAPVAGGTLQTSVPPQGIIPPSLLPTPAQVGAAATILLQQQQQQQPVSTLQPQQSTQQPMMPMPSQPNQTKTQHHLPEMVSVPKDVLMKLVEQKIEAEQRELQTPMKCQCHCQCGRYPGDVLIVDKVMADLLEGSSKQMNSDHNSSNNSTPRLSQQFQPGHFGSVSAVTNGTMPSTVCGTSQSQTILEAMDTTANNSAPTTTAATDQLSNNDQELLADLAKANEFLRGQYTDGDLRRLIAVAKTVEAFKRLDQLDQERLLKRCFESFFVLRSLLTIAVDEFNLSLLRQNGVPETTVKFYAQFPAEWRQNETVNLLLGMLLLFDVEVPGLQSAISVTVENMKFQSILKRFLFVLCERDSARADVANAELLSRLDQLKLMFPAPAGSGTLSAAPCMVSLPMSAATAPLLLPPVHSTASATSPENNGTIAQMVGVEIARTNITICQPSSLFLSAFWSNLNQAISPNGCGVSNLFRLDFRLGYLRSLRCFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWE5</accession>
    <name>A0A914HWE5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g5284.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5284.t1"/>
        <property type="gene ID" value="Gr19_v10_g5284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF61">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="708"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="841"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1389"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="913"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5284.t1"/>
        </source>
    </evidence>
    <sequence length="1439" mass="159505" checksum="26663F7C0CA531C5" modified="2023-02-22" version="1">MAALVGAKRRRRLDRRLVKALHQLSRLLLFFLQSTMSANAILGRWPSLEAIKSRFPGCCANFGSFDCGDGVCLSVSHFHDGIADCSDGSDEHCFPEQISCGSFCADLLHLGECLRNPNCTESTETNHLQAPVPSPFCPFRKRRLCGLANTVSCRGYGQCILEKWLKDGKRDCLDGSDEDEQYANLFQFADRRTPPPASSNLVSTSVTLSPPFPLFSSPPRPFLTSSATTPTILWPILKAEGSKGGTSSPAAISKGEAKENPALNDFGAEFARFLMTPSKMSFPSVTPTSVATPLFGAVFGEEKSVDRWIIFPNWPTSATPEGIPTREWPKGKAPILNGWTATAIKEEENVRWSWMAGTGSSTPKNPFGDEKEGRGGGVEDVQQTNEESQRWTLPFPFQRPGKAELEWTTKAQVWEPEGKVALDGAETAKAIGTQPDGGKRAKGAAATGGTAAPEAAEKSSQRPPLTQRTWTTSTSQLWAASSTAPRAKPSPSSPSRRPFASLTLVTSSPSSIQSFSSPAHRWALPASSQSIAASSKKLIGLNCTARINRMAKELEESAVPFRCSCPPGQFQTSEGFCSFATVSTFRAKIVSLCGHNFADSFSSSAPSLQEQLIVLKLLDSLPDHSFCVRKIVNDGQIVVNTVSELTDGACHQFDLNDCDEKAQCLSDRMLFRCRCLPGTKDNSPEREGRQCEGTVILQTCSKLLGVCVIVWLLMLLLLCFLLPLLSIFCLKYCFKIDPTLLRVRLRHIWRNLINKLKGGEPTKLPTITTSQIADEMRRESLKVLPGTASRDEAVTLKVPSVSNGFGQQATIHSSHRLMPSDSEEYLIVEEGDTGGKELLKREQQQKEKEEGVEEEARLSDKQTARRQQTELSTVPSSSETGVIMLPTAREGSVQSADGTTTRSEEVVEQTTEVEVHEQVERVEEEKKGAEREAEELGRPKSAASRIGTPTIWDQYKILGDQFSKYGSLEIERRKGSVTESLEELLKKREKSVEERMEEAITQRGRVGQGGQREGRDGATKGEEELDANLGLSGKRREAEEREEQVMEEHEEETKQEGEPEEEQRETRKLILLKTLREGTLNIGFVMPPLPDGIGISRRPFFDDAGRLPPPKQHFPFKRRFFETNGGRLYGKAISQPILSKSPAVIREGTADFVVVKGRMGKEEDERLRKLRLLEERRQRWRRGEEARTMGRMREQPEDERKEGGGKRGDRSVTGQRRRAAFVRGGGGKEEAAQKRACQVTPPGAHQGLVRDERSAAKVRKMIMSQKSVPTPMFDPDLPSTSQAAAYWEKSLRRCFSPVGLQLEDYAKRRSDHFRKEGQTLRSIECQLEERVHSGCITSRKPWNISPQPDPDLPASPLFRWSREYIQDASLTPSHLDLGEPEHVDGMALGGAADIDSPKRRRKGRTVRIQEDVADDGGRRRRLGRGTEKGTNAGTWLEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWW5</accession>
    <name>A0A914HWW5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWW5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5405.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5405.t1"/>
        <property type="gene ID" value="Gr19_v10_g5405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5405.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25044" checksum="DA5CAC56A53EEB05" modified="2023-02-22" version="1">MATYVPGASEMPNPSGDNPAVDNPSVDNPSEDNPSVDNPSVKYNPSVDNPSVPNPSEDNPSVPNPSEDNPSVKYNPSVDNPSVPNPSEDNPSYNPSEDNPSVPNPSEDNPSVKYNPSVDNPSVPNPSEDNPSVKYNPSVDNPSVPNPSEDNPSVKYNPSVDNPSVPNPSEDNPSVKYNPSVDNPSVPNPSEDNPSVKYNPSVDNPSVDNPSEDNSSVPNPSEDNPSVPNPSEDNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXG5</accession>
    <name>A0A914HXG5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXG5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5027.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5027.t2"/>
        <property type="gene ID" value="Gr19_v10_g5027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF137">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037196493" evidence="3">
        <location>
            <begin position="26"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="4">
        <location>
            <begin position="79"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="5">
        <location>
            <begin position="340"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5027.t2"/>
        </source>
    </evidence>
    <sequence length="573" mass="63340" checksum="D694F140A764C003" modified="2023-02-22" version="1">MPNPSRALRLSLAVLALTSLSPVPCQPPLPAAPAAIDPLSRNNLSSPPPTAASSSSVPNDVSPLLFQNTNAGNAGIFVRLMPTGLAYLREIGMKVVNDEILKISLPTITEAIDAGQYWPPVDYTLDLITPDTFTWRMSKMHLRSNGNFDARLNGALLLPTVPIQGEFEALLGHLGLTISVRMLSEEARAERLNGVITDFFINTFKAFLIAHFKPTVEQRICQMIEGVINGDMNAVLATMPLKVHINEDNLDLIGKNFGIAPEPTKNLENNSQRKLKAPRNFTLLNFVSQLRDRNLVLDFALIDDPFVSQGTVLMKSRGEISFGGLGGTPFAPPNVIIPQPQGVFMAEFFGTDFVANSMLYHAFKHKYMDVVVGPESSPQLKDVLLTTCSSGFCIGEYLGSLGQQFPGRQVEIHFSAKKAPIMVFVEGRARFRLHGKMDLFVRPENASQRLELVLRSETTMTSNVNLWIERNQILGNATVENLDFKLVGTNVHDVEQSSFADLGLFGAEFLEKLLTEILQIGLLLPSMRGVVLRSPKLTVHDRYIRVQTYFKLDEQYAERLVQGAVRQTLLNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXH1</accession>
    <name>A0A914HXH1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXH1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4936.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4936.t2"/>
        <property type="gene ID" value="Gr19_v10_g4936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4936.t2"/>
        </source>
    </evidence>
    <sequence length="567" mass="64973" checksum="38E8603BD1A8A9F3" modified="2023-02-22" version="1">MSINRQDQNVVEYLCGKIGSILREDSFDYVEHYGEMSNAALQTLMVGRGRELYVKLQAMIGEHLQKMHQQVFISSFTTENKSVDGIDDRILQSLCRQWFEFSEKMIIVRQVLLSSERVFDNSVGEESLIVFAWRIYRSILEQDSEHLPKLLNIVDVRTPNRKKSNILARSKVNQSVRRRSLFSDDTLFDFFRFVDTASLGLSVALCCRRFANFADSVLRGRTHSDCALMLCDGQNDLFPPPKKSENPIGAFAIRLWNSNGAKVNGRGFGRHIYHHGMLIYQVIDQWFSNPREQQPLDLSEIEIPEWITGMSFLYMPIGVTPSVLSFLQLISPMLQNCCLKFELASLWPKLHTSGQLLPFLSLFNPLTFSLQLTFDELSFFRVNNHFYKLPLWATFQSIFFPNCFDLSLPLSLLSSREIGIDVATWLHNERSTVGRPRRVVFSDQPKEINSMGQSFMPGVNAMIGLIKQKFAEGSGKRHFVVESSSKLLNEWDERLLQNGNSECLLVSPKRIVRCSIGDEHTEFEQFHDHLRNGKGTKVGPTVQIGTSSSVRWLKEVMAQMPSQTKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY29</accession>
    <name>A0A914HY29_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914HY29"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5095.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5095.t1"/>
        <property type="gene ID" value="Gr19_v10_g5095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5095.t1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48733" checksum="611FEBA57E4E644C" modified="2023-02-22" version="1">MKKAYQQCDFDFVAPYYAASVHQFNSLPPSTNRSPSPILSQNPLLRIICDKIRTSGPITVAEYMQLCVNSPLGYYARQKKIFGEGGDFVTSPELTQIFGELIGSWIVHELEMTSWQGRWQLVELGPGSGELIIDVLTVLRKFDVLGSVEVYLVESSERLMERQRQTLNSRFGGDLVRVRWYDSLDDVPQGFSVFVANEFLDALPLHLFVRDEANPKKWCEQYVTLDRTDEQRLCFMLSAGENIHTKAWIPQRIREDESRTKWEFCPQAHYIVRQMVQRFTTDGGFALLIDYGHDGSRRDFSLRAKHGMNKKRKKTLLRNKFPIDITADVDFGELSMALRDECLVFGPVEQRAFLGSIGFHHRLNYLLNKSKTKEERVCLLEACRMLIADDQMGSRPVAVRPMDLLRQAEIVKTSVILPNAYVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY80</accession>
    <name>A0A914HY80_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HY80"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5134.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5134.t1"/>
        <property type="gene ID" value="Gr19_v10_g5134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="239"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="739"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5134.t1"/>
        </source>
    </evidence>
    <sequence length="1210" mass="131275" checksum="1E7EB92E0589DF1E" modified="2023-02-22" version="1">MATPQQQLDGRRLGFGIDRGGTFTDIFVAYPDGRTGTFKLLSVDRLNYSDAPTEAIRRVLSDYTGHELTRGEPIPTDHIAWIRMGTTVATNALLERNGEPMALLVTRGFKDLLHIGNQSRPNIFDFDIQVPETLYEEVVEVDERVVLEDPSCKMDISGRNVRAQNGQLVIVEKELDDEGISHSLRPIFARGIRSLAVLLLHSYIYPDHEEAIGRIAEQIGFTNVSLSSRVVPMIKAVPRGFTSCADAYLTPIIQKYISCFRAGFTGALSDVQLEFMQSDGGLCPVENFIGSRAILSGPAGGVVGVSLTAFDTERPVPVIGFDMGGTSTDVSRYAGQFAHAVDSVTAGITIQAPQLEINTVAAGGGSRLFFRDGLFIVGPESAGSHPGPVCYRKGGFLTVTDANLVLGRILPQFFPHIFGKDECQTLDKEASMKAFEELTGEINAQLKQKGRSRISMAEAALGFIQVANETMSRPIRRLTEAKGFDTSQHLLSCFGGAGGQHACAIARALGIRRVMVHRHAGVLSAYGLMLADVVNEQQEAYMKALNDENFVEIRDRFVHLEESCRQNLLSQGFSPVDIRFKRVLHLRYDRTDCLLMCSPTEKTGGNCVEDFTVTFEEQYQREFGFTVPGRAVIADDIRVRAVGRRYLLKADSERGQRADEPAPRKSITKCTFPEGELDTEVFDLSELSYGHEIVGPAVVIDKNCTVLIEPNCRAEITPEGNLLIHLLDVAGGGVSAELDPIQLSIFSHRFMSIAEQMGSVLQRSAISTNIKERLDFSCALFGPDGGLVANAPHIPVHLGGMQAAVKFQIDHIGLPNFRTGDVILSNTPRAGGSHLPDLTLITPVFFSDQSLVPGSMPPHSTTLAQEGAAFHSFKIVDGGLFKETELVEQLMAPQKVPGCSGTRNLRDNLADLNAQIAANQKGIGLLQELVREYSLPVVKAYMAHIQRNAVDAAQDWMDDGTELRLAVEIDEKTGDALFDFTGTGLQVHSSCNAPPAVLMAAVIYCLRCLVGRDIPLNQGCLEPVKVYVPSGTILSPSEDAAVVGGNVLTSQRLCDVILRAFNAVAASQGCMNNVTFGDAQFGYYETVGGGAGAGPGFNGRSGIHSHMTNTRITDVEVLERRYPVIVRKFTLREGSGGDGEPVQLSLLTERRVFAPYGLNGGEPAKRGKNTLCRRRGETRVNLGAKNSAQVEAGDVLELETPGGGGFGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYQ5</accession>
    <name>A0A914HYQ5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HYQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5329.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5329.t1"/>
        <property type="gene ID" value="Gr19_v10_g5329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="307"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="523"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="681"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="782"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5329.t1"/>
        </source>
    </evidence>
    <sequence length="861" mass="93580" checksum="D05FC972354EBED9" modified="2023-02-22" version="1">MKAMDRAVEALVVVEAVHLLAEAEERLAAGVEDLVVVAAVLQLAMAKITVEMRDLGRKAVSAVAEVVEQDLAAAPEELLEALHRPLLMVIMKRKVEMAHRLVVEARGRGSLHLTPAVVLVDLVVGEAGRLEQNGGGQENSSGGRGRGGGTSFGGRGSAGRSFGSFSADRGDGAGNRFGGDDRGPRRENNMDNRSRGQDFGSFGGSRFGGGDGDRATRFATEEERLREESYIPKTRSVDDIFGDDLRVKDKYLDIREEDEDLEISGTNSEGCQQILDNWKEAGFEELLLKNIERSGYTLPRKIQSRTIPLIMDGHDIKGHAETGSGKSAAFLLPLVNAIMVKKKNGEFSSKRICPYALIIEPTREMVIQLYEQALKLADGCDVSVARTYGKYKFRENLKDISTTGCDILIGTLGRFMHLLKEEYILLEHVKILVLDEADQLLEDESARDLRQIAKIDGWPKVEDRQTLLFSATFPIEVQKWADDWVKTTALFVSNKKPVSANMKVLQKFVRVNRSSKNHELLKLFEQERSELKAEKPDEPDPKIRPTMVFVKMKRTADVISTYLNLNKVPSTTINGDRPQKLRHAALDDFRAGRYQVVVTTDVCARGIDLKDLDHVINMDLPIDYTTYVHRIGRTGRIREGASTSFFDLSEDVELAKELVEGLQKGDQEVPDWLKIVADGKMPPDEAETASGANSVPLGMQAASGANSVPLGTENGEETNSVPLAASGANSVPLAASGANSVPLAASGANSVPLAASGANSVPLAASGANSVPLAASGANSVPLGARAQDEETKNVANDETKENTAAPSAECGSAAANHRTPLPADAVNDAWNIRHSFYILHRTLFFFVSSRFRPSGFSFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0H0</accession>
    <name>A0A914I0H0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0H0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6170.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6170.t1"/>
        <property type="gene ID" value="Gr19_v10_g6170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6170.t1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37699" checksum="76A75C2F7903A99E" modified="2023-02-22" version="1">MFLNDFCGWILRNQITLIGLATCVTLPSVLLYIAEIVTVLRHKQFHSSFFALFTARALADLLHTLNSYFNYKLTVSFGNLLFGIYLEFPNWVLTLSIFLGMYSFQTINLATVFISFNRLSIVLVPLNHDKLWSVALLPASILITFVAPLANLIFVVKMDVTLVTSTTNSSFSFIMAEGPKTNLLPLITDISSAIASLSLIICLIVNFGTLLQYKRKINVAAEMAENQRMERKLGIYALHTFAGHMTVSVMMIGMSISHKIGIFTAVMTIYSQYAYVMDWCTIVLSSWLLLWASSSFREQFVADFVPKWLQTIMIEQQQHQQSDTGESLRRHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I162</accession>
    <name>A0A914I162_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I162"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6537.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6537.t1"/>
        <property type="gene ID" value="Gr19_v10_g6537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6537.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="14970" checksum="4F7AE91E4470F307" modified="2023-02-22" version="1">MELGVARSLQLLLSSVLLFSAFCLYLVALIVLGTIETLFLVWSIRLVELSPFLNSPEASARDELFEGRLILLPALAVSLTISTRLGTAKYEGILDVLRTILLLTFAIALVPAAAYSVTFFVPALADVVTHYLEKVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2M9</accession>
    <name>A0A914I2M9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914I2M9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6749.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6749.t2"/>
        <property type="gene ID" value="Gr19_v10_g6749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6749.t2"/>
        </source>
    </evidence>
    <sequence length="618" mass="69943" checksum="78150C983FD77686" modified="2023-02-22" version="1">MGKTQRRAKADTGGRGGSQRRHTVLGLNRAQRKFKRKQLLHTTDPEQHPQSLQNVHDRSGGTNDPIAEDKLMNRGGAKAVPKLLLPSLPSSDNASPPPAKPNQPKRGGAYLSAYKRAQLTFERLQAEKREQRERAREERAQAEAQRELSASWRRKKNQALQLRTAKGQPNLNAQVGILLEQITRRRDGGGGGGKPKRKIFPFLYWLLGTLFGVAHALAVSRLDERVPDAYMDEEFHVAQARQYCAGNFDHWNPKITTPPLLYLLVPLLRLCGRERFVNSVLVPICFVGLCRLRRSLGQRKCKSDVTGVHLPVLAVLCVPVLLDTSLLFYTDLLSLTLLAHALATDGQRHPFKMFLAFALALFVRQTNIVWVCFPCLPVVWTALRTLLVQQQQQSLYGTINFLIRRLWPNALLCFGFIIFLYLNGGAVVLGDRSAHRPVFHVPQLLYFCAFVAASALPQFVLYCFWVMRNGFGTKHWSAISFWRFAAVAIVAGFALVAAVHCCTLAHPYLLADNRHFTFYIWKRLFQRHWLVKYALVPAYVVCAAFLWHSMDTNTVTKVAFAVATSVCLIPAHLLEFRYFIVPYAVWRLHVGGGGDAQPRWVLFTELATHFVVREYTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2N8</accession>
    <name>A0A914I2N8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2N8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6305.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6305.t2"/>
        <property type="gene ID" value="Gr19_v10_g6305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037770213" evidence="2">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6305.t2"/>
        </source>
    </evidence>
    <sequence length="104" mass="11297" checksum="445C30D3BB89C78B" modified="2023-02-22" version="1">MNRLNALLLVSVMAAVLCCDAEIDGFYLVVNARPQVRNAAGVFDAAGQSPVAGNRMHELCKQLLSHCNNAGTSSSAAEQQRFVRLLPVFVVVVTNICLYWFKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3D3</accession>
    <name>A0A914I3D3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914I3D3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g650.t1">
        <property type="protein sequence ID" value="Gr19_v10_g650.t1"/>
        <property type="gene ID" value="Gr19_v10_g650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="326"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g650.t1"/>
        </source>
    </evidence>
    <sequence length="953" mass="110591" checksum="051F585645FD32E3" modified="2023-02-22" version="1">MVRFNPLVEVKELGRLPTPKGKFSLFYALELARNYQLINKGITEMKFRYLEKTDKKQRELVLELMGNLGIGGNAKTYGVGHLGVVQAFWDKEFPDMFRIVAFDLATGLKPLFKGEGVRKYEVCVISNNGHWDGMKSVTKFFKVKYYCVSCEVTYDRSERHRMECKERCKNCCRMGFGFPCKDEGVEIYCEECNRKFRNEGCFEAHKKKVCQLCKKCKKCGALYRTRDIHTCGEKFCKRCMVYHPERQCFIKKTKIRPNLPRYRIVAYDLETTVLNGEHQPNLVSAAVTCSVCAGEEKECEICGEGPKRMTWSMAEGVIDPMSSFVDWIMGDFWLLSQNPLAELPKTLELDIPAKLYFPHKYNKNANFGFRLPHLPPLTDYCPDNLREETCAKLEKWYNENYETEFELGEQLRIYCESDVAILMAAVLKAAHGMGVRDVLCPGRLGRMACVLRRIWEGRMEQVWECDVKKELKRNKEMKKFFEGVPDEGPINPRDAYSGGRTMPFCLYAAASDNVEISMFDIISLYPFVNYDSPYPVGIPKIVQSPNYIVNWTEPDHVPYDGLLKVKVVPPKNMLYPLLSIHADDMLLFANCGICAKTPKKSFVLAKNMKKCEHNDEERALLGTFTSIELKKALELGYKVIRFYRAYHFEEFDSQLFKGYVRMFLRIKVEASGWPPEAKTEEEKRAFIEMYKAKYNIVLDYDNIRYNPGLRLIAKLGLNSLWGKFSMRNTLTMTEIVSSMERYLKLDGDDTLEITMETMIMPGVVRVNYAKKLEFIKEHSVSNIFLSLWTTSAARIKLYEYMEQVYRAEGCKLLYCDTDSLVFTHPKGLCPLKEGKFLGEMTREYAESDILEFVAAGPKQYSLKLRRKSDGEIWEKTKIRGMSLDTSNRVRYEEFKNMVLDYAEGRKKRFYYKDRIRLTGDSKVLSTNETKDYEPVQRKGIIDSEFNVLPFGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3W2</accession>
    <name>A0A914I3W2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3W2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6642.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6642.t1"/>
        <property type="gene ID" value="Gr19_v10_g6642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6642.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12256" checksum="5150C546C787EE0E" modified="2023-02-22" version="1">MFDDLDNNSSTEDEFEQIPRTFRTRNTLDKYGDQSVVFAFSTLNDVNFLEGDHLKTLAGASGVHFATVSRVIDSVTDALLEFAPNYVRLPTAPVELQQAKSGFYSVFIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I490</accession>
    <name>A0A914I490_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I490"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6744.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6744.t2"/>
        <property type="gene ID" value="Gr19_v10_g6744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6744.t2"/>
        </source>
    </evidence>
    <sequence length="204" mass="23280" checksum="9813EE4F24C6FC64" modified="2023-02-22" version="1">MDKVSILVRSETKCSKMDKVCVQNFERRYQSCYSWYSTGTELPSLAKFGLPKGMECELWHKWCKRVMHGRSPPVERNAATQTEEGDPKSAEPPHSPRKRKCPPARGVRHASGDLGPPAANSLQKMPRHHYIASKIRRRAMLCALQCAIHRRTTFNPMTTRIHFQKHLKVMPAGTNNGTHFCALQANIEQQICCQFVQIINLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4R4</accession>
    <name>A0A914I4R4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4R4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7293.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7293.t1"/>
        <property type="gene ID" value="Gr19_v10_g7293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052860">
        <property type="entry name" value="NRL-GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47521:SF7">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS EPSILON-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47521">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS E (EPSILON)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7293.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43886" checksum="B787038CC583A9A7" modified="2023-02-22" version="1">MAVDLCYIEALTILDPWSNIIRVFQCVLGTSTLISLVVLIRQFHRSRLTFHGNLMLLIISVLCLYTLYNISLIGMAGRTLALYLFWPVAQFVSTTGTSNSDNLTTTPPASQSEGEGEYRCDALLVPVWLSVLLRLPTYQHALTYPLLHFAIMAERARATLHARTYEREGTRFGTTACTIIWALYAMFSVWMVLSTLADDAFDQPQLNYTMISRYNTGTVIILNYVLLGVVILTAFADMAIMWQNAKMYKKRKKFVIPSNNNSLADDSDHSQYSLSRAYQLNENMVSLQLFLPLDLAFAVAFSLYLFFSAFLRTQYNQIGMLFLPLYELNTCLLPLHTLLTLLVYLRFVRQQSIDRKAWSTATACNLSVEVQRSLYMQHLKAQWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I583</accession>
    <name>A0A914I583_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I583"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6902.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6902.t2"/>
        <property type="gene ID" value="Gr19_v10_g6902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="397"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6902.t2"/>
        </source>
    </evidence>
    <sequence length="1111" mass="127007" checksum="AD71568B39CC02ED" modified="2023-02-22" version="1">MQEINTECNYATTGGIGGNLLEHSLFALSIDNSSTKTFITIRGICKENESDKKRAGRSPQIYHGLVSASDTGDINLDTIRHDLDRARSERTNPTAKNVRYNQQLRRYLQMRNERESKPTKLELSKGLSVLVKRDGEEEAEVVDTPQPPAQGQRRITQTQQTSRPQPSNRQQSRKRKATNLRADDSSHIKKNLTTADREAIQRFQWQIGRKRALRRPTRNVPERDLVAEAAAAPIIDEDDDDDYLFENGSTLPAPSILHGDLPDDGDENSNDPSRRGTKRKASTLAEPKRQPATKIVHVDRKRKWTETHHPVEPEEKRARSNFVLMDSTNAKDKDQLPTTKMELVLDTLYNDPSSSAAFAGVNALWKEARKKIKDLRRKDVQNYLEGHRTYTLMRPRRVRFPRAKTVAAGFMTDVQVDLADFQTLARHNRGHRYLLVAIDVLSKRLFVRPLRNKRAEEMLEAFKRLIEQMPMAPHRIFSDKGTEFKNRLLKEYFEEQEIEKHEPVHSSVKASIAERAIRNVKQRLYRYFAQKENLNWVDVVQKIVDGINRAPSRVHGMRPIDINFQNAQQVWKRMYGKQVGNKRQRFRKDEFVRMTREKGQFEKGYLPNYGDEILEVDEVLKKVRPVRYKLRDDKGEKFKGSFYEQELARFNGSWVCGLHSISYPYSWHTTIGTLDEQWIDIHFLDYNAILAEDRKRVIRIPVPKASHQKVEQLRDFLASTLKQQSQLVQSRLNSSPERQLRYSKLNLSLLLASTTQQNPMPHHDPYPQHQKHHIPHACNSKCNTNTNYSKTNPSRTGACKTKDNTDTTTTATTLSACKTKDNTDTTTTATTLSACKTKDNTDTITTPSACKTKDNIDTTTTTNTTTINTTTPTSSTNIATTTTTTTTTTNTSTNTSTNYSKSNYTSKTNPSTDTNKHSDYSQGDYNARQEQAKKPLSTYNLRRIIDAVKIEYLENIARFRVIFKERSISHLSFSPQLGYVLGFQDPQNVQGLTENMIIGNSLSSLLRVVSVSGATPGEYNEKIYDSPIFARVLPREINEIEIELRTMDKGRLVPFAYGTTLIVLIFKKGPARSSEGTVFKEVLGWVMFFAVFGVSSYPFCAVSVQQLERRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5D8</accession>
    <name>A0A914I5D8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G2/mitotic-specific cyclin-B3</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7046.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7046.t1"/>
        <property type="gene ID" value="Gr19_v10_g7046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF31">
        <property type="entry name" value="BESTROPHIN HOMOLOG 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="692"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="14">
        <location>
            <begin position="787"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="791"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="596"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7046.t1"/>
        </source>
    </evidence>
    <sequence length="907" mass="104933" checksum="03234FFEE5E250D4" modified="2023-02-22" version="1">MNPNSKTLAVTYSFNLLNSIQLAELLKEYICCSPKLCGTTTRAVEVTMTISYEEEFSSLMLRWRGSIWKAVLKDLIAFYIAYYVILYAQWGMMDDSQKEYFTGWIKWCEIGTQYIPLSFLLGFFVAVVVARWWEQFNWISWPDKFMMCVSTCLPGRENMETRKTLARWTSLQSAIAWTGISVRTLKRFPTERHLVESKLMTEEEYDMYTAINAPHGKWFVPLMWILNMLKQKVHERRIDTVQLQMLVEQLIKFRDGFAMLYVYDWVKVPLVYAQVVSIATYGYFFICLIGRQPKLDPKSMEQEITILFPIFTTFQMLFYIGWLKVGQYLMNPFGEDDDDFELNYVLDRNTYIAHMIASELADQIPSKITDEMEVTLPHTRASFKIQDIIPKGHLTDFQIAPKDMQLIRANELANAMMELEQKRKKLSTIFRTAGKKDGGPKVVNSKDSVEENRRLTTSIEEEMMLRNRDLNVQKNVDARTQQHKGTGHQNAAPIGKGGNKLPAVAVPHQKRQAAHLVKTGESSSGSDKDMKDEPRPKRACSQTEKENNNTVGNTVVPVTAFSRSLLIDSTKKELGAGGAMRAAPIVGRKRTSALLTTRDSNVGETKLSPSQEEEKLENEQKMEQDEEQQPPPSQEVFNFDKENERDMAAMSQYAQDIFLYYKYRERSFQVGDYIRAGKHPEITSEVRAKLVDWMVELQETFELNHETLYLAVKLVDMFLNRTTNTVLCTQMQLVASAAIFVASKFDERAPPLIDDFIYLAEESFSREQILEMERVMLKVVDFDLGAPLSYRFLRRYARVCKLDMGTLTLARYVLETSLMFMDYCRVSESRIAAAALLLALRMKGIGDWGPILDKYTGFKRSEIESLMWRLNRMVAERKQHYPDLDTVFRKYSHEIFFEVAKIKLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5L7</accession>
    <name>A0A914I5L7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5L7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7728.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7728.t1"/>
        <property type="gene ID" value="Gr19_v10_g7728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7728.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26544" checksum="8EABDFDA36DB99EE" modified="2023-02-22" version="1">MHNPIVEDLTPISPTRLAELIRHFYSLGWMRDNGGGMAVLCDGVVYSSPTSVQKEKVAEEDLFVVDVSTKSVLKRPNNPTSVPSATCGLLLNTGMKCVIHTHSKYANLVSQLVKSKEFAIQNQEMIQGVENRKTGLRLDNIDRLVVPIVESELNEEILSPVLLRTLDAYPEASAILVRGHGFFVFGSHCWQSTKMMLECYEYLFELACDMIKYKLPLAPPLPNTKTVQKMKRNTTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5U9</accession>
    <name>A0A914I5U9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5U9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7050.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7050.t1"/>
        <property type="gene ID" value="Gr19_v10_g7050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7050.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22425" checksum="04B58EFDBACC4D30" modified="2023-02-22" version="1">MISSRPRKESKSKKFIRISSNNNKRVHHQQMARVPSRALRQSALQYPTVYYICGEFPNLAYQLTPCQRCRNGGRALYAQCTTAVQCTPYYRGPTECIEVYINYPDGSAGFFDPYQNGAQGGYVGEQSEGRLSARVSLPKRFLLCLVRHSDVPEWTTTAQLSDRLQLLAGRHLLQKHDYLTSIESSFYCNSKKDLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5Y2</accession>
    <name>A0A914I5Y2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase</fullName>
            <ecNumber evidence="4">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914I5Y2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7811.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7811.t1"/>
        <property type="gene ID" value="Gr19_v10_g7811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IA-type catalytic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7811.t1"/>
        </source>
    </evidence>
    <sequence length="785" mass="88469" checksum="7F3DC4ADDAB25D61" modified="2023-02-22" version="1">MSRKENISERNRSAEDHRSMTPRQQCVVTEGANGGGNFPPDPMGTVYVRQEQPPINSSSSSDNNILVTSPVLSSSFEAVPTPPIFTFAPPPPDFPLQLKILHILVAHIGNGEQKEKITCRLQSPSAVAKGDSGFVVEHELGPFNRTDKVFADHRFRDLERRSQASVAEFGSKFVELQPPPPMNTLTMLCLASDRLQMDPQVTIELARKLNKIGLISSPLTSADKYSAGFPRKEMVSAMVLHLDELCGVRLNAQDVLLNFVRPNHRLGSMEPIHPLLVDHKDTKYKRALNDDELARKLYELICRYFLSTCMRPSKIAEMTIKFSIGPEIFKSTKHTVVIDGFLLVAPWMQPEYSDTELPTEATKLQNQFVKQTFIVSDVQRCSIEKPKGGLSEAKLISQMALLELGNYGTIPETLSKMVQKKLANVIEPGRWIVPTSEGLQKLESFRHDGFETDCEQEQTSDRLFEDQNDQEDESVEIGGCFRNRIELEANRWLRLEDAMQSEIGLRLVVIAVHPRKNREANAFQTRTKLNAIFQMKLLHVDSRWWTAAMFALVLANLNSISDISVRKEKASRECLVFLQAGHATKALEVIPRQKFMLATCHLALGSAFVDFARVNEAKRAISEMDGRSLDGLILKVKCQQKRPFTELSKQQGDSQLFSPGNKFARNVQTHPWQKSQQSSPSKEYLVGLSAKKQSPDHSPRIDKHSGFQSVRAYPWRTNQQNSSSDELSVQSPHKKMRFADQSATFGTPTSYRPSPWAAGKAFFASSFFARSPSVFFPPFFSRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6B3</accession>
    <name>A0A914I6B3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6B3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7165.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7165.t1"/>
        <property type="gene ID" value="Gr19_v10_g7165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7165.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11945" checksum="460FBD83597BE269" modified="2023-02-22" version="1">MAVGGGSQRTFKERNDGDKMCHCLPPPVAFEAFFALSIQYREDVRGKGCTGAAAGGKGRGNEEEEEEEEEEEENEAWGKGGGRKMEMGRRNRSRMIGKNEDEEKEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6R4</accession>
    <name>A0A914I6R4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6R4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7419.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7419.t1"/>
        <property type="gene ID" value="Gr19_v10_g7419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037907875" evidence="2">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7419.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22215" checksum="91FD27F586874671" modified="2023-02-22" version="1">MNRCYSLFSSALLLISLLAVGVGAFWPYAGGQPVDATTVMDAPAQSAAADDDASATSGDGQQPAVQSSSFHELTLVNNGCVYHNGMITDNGGQPRKATAEEEAKVQEYLSASQRQQQQFQQSMAEQMRRVFAPPFPFGQNAAAWQFPQFPQFPRAQMVETPCFCENCRNATSMVQGMSSSMGQGNTANAYNQYSVVGGQQQQEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I717</accession>
    <name>A0A914I717_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914I717"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8097.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8097.t2"/>
        <property type="gene ID" value="Gr19_v10_g8097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="435"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="746"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8097.t2"/>
        </source>
    </evidence>
    <sequence length="906" mass="102990" checksum="52E6CC93C33D370D" modified="2023-02-22" version="1">MHREIRELIHMQLHRCSDTWCGPKDPKTGRCKKGFPATYSKCTILHPDRPAVYFRPSPAEGGAQIEVNNLIYDNSHVVPFNPFVLIRFRVHHNVLFAYGNKANIKYALKYPFKGPGHCYVECKEESGNKIGIDEPAQYAKMNFRGATEAYAVVNSIAYVRLSHHVVKLSIHLPNQQPIVFRAGQLVSKAQQIEQGDLPETPCSAYWKQWQNEWKDEPEFKDMLFVQVPERFRWVNDKWVAYKRKPSKRPPIGRIVPVPPSDPERFALYQLMRHYPGDPDHLKMANQQPCTSFIEAAIKHGLLEDDRVWDKTLEEASLSRWPDQMRWLFVSILVFGQPSNARELWDKYKEHMYHPHGIASKAQRLAKELQALADIDWRLFNFGFSCVHFGLPDPPNSIAKNTEKAVEEFFFGDDDLNVPPGLPNANQPQQSQTPPLNSDQQMVFDAVVKAIQTDPSDQSVPRRLFVYGDGGTGKTYLFGQIIRRLRKAPYSNKVLATASTGCAAILLPYGKTAHSTFRLGREVSLDKLPSIPLESFFARRIREAQLIIIDEITMLNNTVIEVIDRVCKEMAIRQHKELLFGGKTVIFSGDFKQSLPVVPHEGLAAQVAACFQTSPLFGQFTTMKLTINHRLGKGQQDYMKMCRQIGHGETGEFFWIPPQFLVQSSEDLIDFVYPDFQKLLGNDKELLNRLILAPHIQTCDEINELMMDNVPGQVRDYLSTDKPLDERPLDIDEIESEVAALNQRTDSGMPPHRLRLKVGCVVVLLINKSDREGLINGTRIVIEELGEEKITGRAINGTAVGGQVRFFIERTRNVYEDKAPGGLKYERLQFPIKPAFAMTILKGQGQTIRTVGIDLEREVFSHGQLYTAFSRASDGNNVRVYAPNRETDAQGRARVLNIVATNMLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I817</accession>
    <name>A0A914I817_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L13a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I817"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8342.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8342.t1"/>
        <property type="gene ID" value="Gr19_v10_g8342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8342.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23266" checksum="1EA8310F021B20DF" modified="2023-02-22" version="1">MGFSTKPIIIDGKNHLLGRLAAVVAKQLLLGQKIVIVRCEAINISGNFHRSKLKFLAFLRKRCNVKPARGPFHYRAPSRIFWRTVRGMLPHKTARGMEALKKLKCFDGCPQPYDTKKKFVLPNSLRHIALKPRRKYCTVGRLAHEVGWQYQGVVEKLETKRKVRGAAFHEKKKAELKLKRRATENAKAKTAPFDKILEQYGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8C7</accession>
    <name>A0A914I8C7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8C7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7846.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7846.t1"/>
        <property type="gene ID" value="Gr19_v10_g7846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7846.t1"/>
        </source>
    </evidence>
    <sequence length="524" mass="56903" checksum="3767EE6D3F422354" modified="2023-02-22" version="1">MDVNFVLTDASAGSYSNQQPISIHHFQNQMQSLPTSAQHSQAEANFYLQQRQFNATQGHLGNFSEAQNQTATASQHFEFAPNGYLQENDAMLQRQQQQMAVSSPSVSSTADLSGGLANGQNGIRYGGICGGAQHLDSTCFNLQHSTVDGGVGNGDFCGTTMVRQSPQFCAMNGQMLNGQSGGMCFPPSLPSMMMPSPNAALRRTFLFSSDMANSAVKSMQQHLAEDMAGWHLKHCVPSTSRAMFEPKITMNSNQSNSPAPQTTTGRGTKRKASVAQSATELQQPHSMSLSPRDVRPPSYTSSVGHPQSAPILSNHHDQPQHSNELCDSSTNGDIDMFKNSSGQLQSNGAITNYMQNGPFGQMDDPLKKMEIMASKTLNEPTKCRMQRLCSEDDSNQSHQLLVGAVDASKQEKMHKLYAIEKALQSVAADTSPSYPNSSPFSDSSQLRPHFFTPSQIQAPLHQYATARTMGSFPQNHSVKMAMMNSSQQMYNSIGEHLGMMQGGPVMVPPAGSSEVMSQQSWLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8P6</accession>
    <name>A0A914I8P6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8P6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7669.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7669.t1"/>
        <property type="gene ID" value="Gr19_v10_g7669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="107"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="209"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7669.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41591" checksum="DFDCFBB109E802CA" modified="2023-02-22" version="1">MPGICGGIVRKFNTSKNGAKRQRTDGTEKTFSDESESSDIDHNDLDMMDELSERDMDSSEDENTEDFDEDALNEEVEEEEGGQKKEKVSRRKRLKESLANRRATESRTVFVGNAPSTSTRRDIRKLFRSFGTIEAVYQRTLLQMTEKLTKLMQGKDKTLKDRLKSTNFFVRFSSQEEAESAAKQMNGTNLDGHTIRAILSNRHKFGQSFSIFLGNLPYAASDEQIRTHFAPCGPIVAVRVLHNKCNGMGTGAAYVQFEQRESCAKALEMNGQTLGGRPLRVSKVAKKNKLSAKAKGSSFSSNGRENRRDNFKNGGEVPEGSEKFIVLKRKQRRPPGTTDGRAGGRADPQIVGQRPVDQPPEDVSHSSYQPPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8T6</accession>
    <name>A0A914I8T6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8T6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8557.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8557.t1"/>
        <property type="gene ID" value="Gr19_v10_g8557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8557.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32442" checksum="F30C720375F28DD3" modified="2023-02-22" version="1">MVSGANCPFNAIITMTTLPSVWMRPTKQNSFAVDAPERCPAAPPRGDVVGRRRMATTMKHQHRQHSHFSATTVQQKRCVHLRPNCFNSNPVYSPSSLCRHTFSPNVIVLLTLLMLFTVGCPMSVAATARARRTLPLGMDRQMFPAQIFDENAPICTVEREPCGFYSFSLDGKAPLKWIKSWCRCSDQYECAYERTDMRMRVYRQTCIAHDDLLEVGDEDNAAHQRQSVVLVDTVPSSVRETTGHARSHRHHNHHHRHVTTARHSRKAHRQRQIIRRLRAIIIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA01</accession>
    <name>A0A914IA01_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA01"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8267.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8267.t1"/>
        <property type="gene ID" value="Gr19_v10_g8267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8267.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45568" checksum="0B876D60E978757C" modified="2023-02-22" version="1">MASNFAHRHKICGFLRHVQSVKRHFSSSSPCLVETTNSAEIEESGLNDLMAAQIEWKREKDAELLARSQRAKLAAVRRLHDFLLNGPKEASTSIWRPLGVEGRAECDRILAHFEERMAEEMKKTEATLVAVAEQRKIPRQIERELDVFKTLYLRVLFRLFREVYRLGADEMQKSGEKGVQRQRAEKAQVERLNAVFDLVPEMTELKRHCFLGVFWLSDGQSFRFLDHLNTKCGRSSLDGPHVNFICHIAIATKEAPILEPLTELATFLPSNFLHIAKVFNSLALIYGQTDNFDKLEELWRKLDRMKRNVPFAEQRSRMKPILARIAHFFRTANRTAPGSLQAAIKRLDGQPFFISAHAKKREGNTLLYCNAICVRFVLHAVNEPIGRVVFWIILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAE0</accession>
    <name>A0A914IAE0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">R3H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAE0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8158.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8158.t1"/>
        <property type="gene ID" value="Gr19_v10_g8158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8158.t1"/>
        </source>
    </evidence>
    <sequence length="464" mass="51545" checksum="CCB0EDF06E141FA7" modified="2023-02-22" version="1">MDLRQASVTKRKHFLRSDAMVADEDAKLDTSRKKEVHEYRRSSIASNSKDSFCADSTGVDILRFIEETLHKNAKDRDFLLDTEQKLRELLLDESQSFLVFPSLSSYNRMLVHRAAAFFGLLHNVDQSGQKVVVTKLPGTKLPDIDFEQLIKHNDFFDSQSTRRNVHSFDETKERRYPMREFRSRFNTASSEGINGIDLARNRRARSFEIDNDWYAGFQRQHLALHRYSATIDYPGGGDGVSSNCSSSASSTAISAQMLPLHLSMLQATYANSSNEASMISPASAYSEPAAVQQQTVQCANHQSQISSRATAADAFPNAPNQFFTHPSYYPVAGYRQQTVPPFVFSHSSVLSPTAIAPNYPPGIAQPLLYYPTSSGAAFYQASASAYQNPFTQSLPLMEENGHNLLADQFGQIVLTENSDHQGEAVHSPLVEEGRQLTVEGTMATNTTGQTRQKHGIAIGPNDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBI1</accession>
    <name>A0A914IBI1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Alpha-ketoglutarate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914IBI1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8410.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8410.t1"/>
        <property type="gene ID" value="Gr19_v10_g8410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000007">
        <property type="entry name" value="2-oxoglutarate dehydrogenase e1 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="18">
        <location>
            <begin position="631"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8410.t1"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113824" checksum="15E781014C53FF0E" modified="2023-02-22" version="1">MFRIVSKRSLSTTRRWLQQPSAGTTASRVPSALTAEPFMNGTSGVYIEQIWDAFFSNVHAGAAPGQAFQAPPTGFGIPSLTTVPHATVVPRDMREVQPQTATQVIPADEMTRAINDHLKIQLLIRSFQTRGHNIADLDPLGINSADLDDTIPRELELEFYGFTEQDMDREFLLPPTTFIGGNRATMRLREIYNCLKKIYCHHTGVEYMHLTNYEQQDWIRKHFEAPKVTELPPDQKKVLFKRLIRSTKFEDFLAKKWPSEKRFGLEGCEVLVPAIKQVIDRSSALGVDSIVLGMPHRGRLNVLSNVCRQPLSTILAQFSTLEPKDEGSGDVKYHLGVCIERLNRQSQRMIKIAVVANPSHLEAVDPVVQGKVRAEAFYSNDLDCDRHMALVLHGDASFSGQGVVMETFNLNDLPNYSIFGAIHIVVNNQIGFTTDPRSSRSSPYCTDVGRVMGIPIFHVNADDPEAVMHVCDVAAQWRKEFKKDAIIDLVCYRRYGHNELDEPMFTQPLMYQRIRQTKPLLEQYQKKIIGEGIADQQYVDEELKKYGSILENAHESAKQVTELRNRDWLDSPWDDFFRGKNPQQLLPTGIERDSLEHIVHKISQVPDGFNLHRGLLRLLKGRKEMLADNNLDWSIGESLAYGSLLMEGIHVRLSGEDVERGTFSHRHHVLHDQKIDQKVYNPLNDLTETQAEYTVCNSSLSEYAVLGFELGYSVVNPNSLVIWEAQFGDFANTAQCIIDQFISCGQAKWIRQTNLTLLLPHGYEGMGPEHSSARPERFLQMCNEDDGVDLKNVTLDEAFVARQLSDTNWIVANCTTPANFFHLLRRQIFLPFRKPLIVFTPKFLLRHPLAKSPIEDFLPGTSFRRAITEDGSASNNPSGVERLVFCSGKLYYEIVSERRNQCLEDKIAVVRVEQLSPFPYDVLMAECNKYTNAKVIWAQEEHKNMGAWAFVQPRFLSFLKQLGRGLTYAGRTPSASPATGNKYTHGRETAEVMEAVLKKPIEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICK0</accession>
    <name>A0A914ICK0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICK0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g936.t1">
        <property type="protein sequence ID" value="Gr19_v10_g936.t1"/>
        <property type="gene ID" value="Gr19_v10_g936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11418">
        <property type="entry name" value="bHLH_TS_ASCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="187"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g936.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31008" checksum="D7DEB1A32E5EB257" modified="2023-02-22" version="1">MPMSNGATCLAAGYASGQFPGNPCAKLLSSPAHIPRMIRLGVGHSQFNTIVKIATQPNGIVSSANAAAGGAPLGTLASSGRLFRQQFAFSDGHRCNGPLHGQQRYQQQQQQQPPVFITAAAAQTFRQEYLMMRTNQHAAAAEPSKGNPNIRCPVSQHYAQPKTMMTSNDFSLSKKRGKYKGKFKQATAVERRNARERTRVHTVNQAFVLLRRKLPSLAKNTKRVSKLKILRAGIARIDQLLRMLDHEVMPPFGFGTDLRNNDWSNNSKESSVDRWEEQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICM5</accession>
    <name>A0A914ICM5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICM5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8659.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8659.t1"/>
        <property type="gene ID" value="Gr19_v10_g8659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF69">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8659.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32369" checksum="D74077E2C5DBC666" modified="2023-02-22" version="1">MDVPSGAALFKPTESAVPRNIGQESLNFHHPKFWLKSPPPRRHILPSSSFLLLRRPLTNNLVPPFLSSSLSSFVHQSQVVKSQRRPPQKHFRSIAAGSKPKLSKEDLEFLKKNTNFTEEQIKEWYKGFVQDCPKGHLTKEQFIKVYKDFFPSGSAEGFCEHVFRTFDTDNSGFIDFKEFLLAINVTSSGTPEQKLEWAFRMYDIDGNGTIDEKEMIKIIEAIYEMLGPEVTKSADDSPRKRAKMIFEKMDVNNDKELTLKEFVDGCLADKELFQILTNEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICR1</accession>
    <name>A0A914ICR1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICR1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9634.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9634.t2"/>
        <property type="gene ID" value="Gr19_v10_g9634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037368389" evidence="2">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9634.t2"/>
        </source>
    </evidence>
    <sequence length="170" mass="19381" checksum="8A18999627E13AA2" modified="2023-02-22" version="1">MKVCANAIIMPISLLAMLTFKGINGIKCTAGYYFGNRIMPLPDCSANKNCFSALCLHVHHNDDRAHYDDGRAQYDDGRGHYDDDRAHHNDNKANHNDDKAHHNDDKAHHNGDKTHHNDDKVHHNDDKTHHNDDKWPQLQLHNIFSDLNLDQTKLSRPAKQIAILASNLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICR3</accession>
    <name>A0A914ICR3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICR3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8690.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8690.t1"/>
        <property type="gene ID" value="Gr19_v10_g8690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000001">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8690.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="50919" checksum="FB06951EB2C722B3" modified="2023-02-22" version="1">MAETYNVKVKENSTIAKLKKIMSQKLNQSEEKICLIFSGKILKDHENLTQHHIGDGMVLHMVIRNQPLTSTTSGSSNSTAPAAPTGGTGADFTAGVLNSPFMESMLANPDYIRAVLSENPQFQQIIQNNPELGHMMNDPSNMRQAMEMIRNPTAFNELMRTHDQAIRNMQGLPGGEAALQRLYEQVQEPLMNTVLGQPGVGNATNPPGRNATASRSQHAGVENAQPLPNPWSNLVNQQNRQGAGPAGGASAQGAAPPGLPFANMMNTPGMQSLFRQIASNQPVMQQLSQLSGQPQIASFMANPQMLQALTNPRVITALQQMQQAYQVLHQEAPQLFANLPGADMLQNFGGMANLFGGMANATSQAQPPASGDPNAGGTQSNGSSGPTVPLQPANIPSGFAELIGSLMNLSTATNSTQPPEERFRPQLEQLTAMGFTNQQANIQALLATVDMATLGRSEETSKERRAATSFGLMLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICU3</accession>
    <name>A0A914ICU3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8734.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8734.t1"/>
        <property type="gene ID" value="Gr19_v10_g8734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF47">
        <property type="entry name" value="NETRIN RECEPTOR UNC-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="93"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="269"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="12">
        <location>
            <begin position="1216"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="784"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="752"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8734.t1"/>
        </source>
    </evidence>
    <sequence length="1316" mass="142884" checksum="DB2D0F624AB74198" modified="2023-02-22" version="1">MFQFDEEWEPRDEARLKQKPINAENGLRSIENGAEAEGEGLDGGRDFYGDYFVAEFVDGASSPGRMDLQHNTNTSPAQTPVRPSNAPSPVPVPSLTRFIRHPQSDFVVRSRPAQLQCTASNAHRIRVKCNAKWLDDQRVLQEEGVDADSALPVVSASVDIQRAELDAWLADLGEFACQCWAFRGKRREELSGDDRLEDSEEDEEEEDEEEDGKDEEEDDDDGQRGASTSRGGHGDGHDGTTTGVRSETAKIRLAYLRKHFAQGPIARRVEEGKTVQLHCQPPDGDPRPEVHWHKNGQIVHFAPGSPLIQAADGSLIISAARLADSGNYTCEARNPANRRLSEAAQLEVYVDGVWSPWSEWEGVCAVLVCPVLSSELAMVRGDAAAVQRVLPQQRRTRSCNNPAPLNGGTQCAGPAEELRECTHGCQWDGAWAQWTPWGRDCDANCRRWRNRECTAPAPSNGGAPCAGGDAQWRNCTGSDDLGLPTPAHCRPDFIQPNNSPSSHIKSSSDAVPALFDSNMYVLASLGCVAFLLLVIAVLCGALLCRKSNLRVPKKKNRDAGGHKSSAQCGLFLDKDEKMYFPGAAVAATTEDEHGNVRTVLLSAEQKQALLAASSASGDAFCVSNQSTPGGRFFSLKPGGLSTHGRYRRNPPPPHLPPWTPQLHATVSTPTSAAARLTALLHSPSKGTVNNYTVRSWNSGGGGTTTGPYASTGLAMANGRRQPRGGDVAGSQAALLPEYGSSFSSQGSGGSGRFRRPPSSRQRHRCPPAVEENNYATLYEELTARPETVPNPSSSSGSDSITSAEYALSSSADTRPLPAGSDSSERDGPTFVAAEVDGESTRIELRRSGAALTIGERTFSRTRTLFLSVSDDAAERPSLADGDTWLSPTVAFGFCDQCSSAYGMARPVVLSVDHCAALFPREHCWHFALHAQLTDDVASNASWVCVWQSDDQIGSDDNFGVQMERQRWHLLTRRSGRFLLAGRARRAHVAPQKRVHLCAYWTPPASLRRAVPPPPRPADCSTNPYDPVPIGSVELAQLRVYCVLETAMSVQSVRQQEEQQLDGVLLAETDNFLLAPKGPLCCCLEQIAFPGGEGHPCGGSQYLEIPDHVHRWCAQNGLHFQLSVPGVPSPTPSPALPRSLSGRIVLYQKGNTADRQVLSFAVDADDQNTFCKKMGRDDSSLSRLSAFGTDQLVSTQLQLATSVRAQLAKVLEEGVPDWRALADKLGLCGYIRLIETEQQPALTLLDLWEAIHAGSERALLDLLQHLRVLGRADVVRLLEQCLTTNHSVSHCPAAAPFCSLNVLPEESRDELRRACSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICX0</accession>
    <name>A0A914ICX0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICX0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9448.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9448.t1"/>
        <property type="gene ID" value="Gr19_v10_g9448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037009821" evidence="2">
        <location>
            <begin position="37"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9448.t1"/>
        </source>
    </evidence>
    <sequence length="872" mass="97669" checksum="A58621B6E205B310" modified="2023-02-22" version="1">MSGCRFLALQFPPKMLTMKLLCICGLLATLQNVAVAMNNPYQGGTAPPVDNESGSEEEDEQVPPQHAGGFGTGMHQQSNMMMHGGVPVHPSQQWPQQSSALTSFNSNNPAQQQYGSQQHPGMNMPSPTGSFNSNPNSMGSFNSNPHSMGSFNSNPQFAANPQQPNMGMMQQQPNNHLPQLFQLMQQQPNNPMVTQLFQLVQQQPNNPMISQLFQLMQQQPNNPMISQMIQMALQPPAVPAMPTMMQQNSLNRNMSSNPSMLHSSPSMSMPGFQPNPGYGPNQGQTPPKTTGRRNSRTSNASGLSNTNVMQPPAFVSYYVHEERVTYPVSMNQNGADVMPFMLEACVDMDLQRKRLSLMDCVENPKSKTKKILADKDPAAIDYGKLVKKLLEVEDSEDTWTNHIHTLQKAWITDVDQNQSQKKAASFPFSGGPKNPYLKQLIINSAMNRDVLLFLSLHNATFGRPNTDFADLNEIMVTTTNKERENMRTLYSNINPDKNLCTALRMEESKLKPHKYGLIIESLCQTNRDEYFKLSNNDKLQDINQDAQIFLKLLQIEVQLTCGDDVLKKVHKALDTVKDVVLRAMMSLLRYICCCAKNAFNDATRILLLRGPVDLIDIRDEYGDEKKLCLKKEDIAKVKQKGIKYEDAVKDRFNSDEHLKKHLYSLHDTFANKKKDSEAYAISGYIDLLEWLEKKEEGNENVNWMIIQKDAIEAFTETDLLKCMTADEKPHEHVIVQATGQIYPLENSQMDAANMMMPPQMPPHLTNMASFAGYGMQQGLPGNQGFGGNMRFAQQPQFNPNVYGAGLPGNQSFGGNMQFAQQPQFDPNVYGAMAAQFSNMGIQPGQNQYQQQNNQQYQGGMTHQGSNMPPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID22</accession>
    <name>A0A914ID22_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ID22"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g948.t1">
        <property type="protein sequence ID" value="Gr19_v10_g948.t1"/>
        <property type="gene ID" value="Gr19_v10_g948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g948.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27538" checksum="96CE1D022FB96B7F" modified="2023-02-22" version="1">MSSIGTGYDLAASTFSPEGRIFQVEYAAKAVDSSVTVIALSCKKGVLVAVDLPQPSKLTLKTANTRIFKVTDHIGLVGSGLHQDLNAVLDYAKDEAKTFLKDNLQPVAVKKLARSVGERVHIFTLGISRPYGVSLFLVQWDKDVGSSIYCVEPSGQCLKYYAWVIGKNAQAAKTEIEKIQDREQLDKTELAKKAIHTLLAVRDEGATGQRVEMAWVGEDSDGKFEVIPQENIDSWEAFVQEEIRAMEQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID38</accession>
    <name>A0A914ID38_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID38"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8796.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8796.t1"/>
        <property type="gene ID" value="Gr19_v10_g8796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057233">
        <property type="entry name" value="DUF7911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25492">
        <property type="entry name" value="DUF7911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038055664" evidence="3">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8796.t1"/>
        </source>
    </evidence>
    <sequence length="549" mass="60112" checksum="910D15D61E7F3008" modified="2023-02-22" version="1">MSRWCSPLLLFLLLLVPSPSLPSAPKRCPSPFFRQSRSPSPSSNGTTPRHSSPIHFYAVTQDCQFVLVRPDQLGQLAALPVGTSHSAAADCAPSRIQLLWSLSSPGPSLLMIQQRAHNKICLLPIEMPFLMTAQGSELFRYSLRNALQHFAHCHVTNATLPIEPNLLFGDSLYSDILYFLDPTSTPEAVWTVHQFHLSPSGHLRPRDTFRRVKPMLKNISHRKSFLRDGSPVLLASDPQRKRMFAVPRAQSDLAAESIQWTCPFDLIFRPELVQLHPLAMFPRSKSLLSPGSHLTGFAVDQNVAVFTESAAPNSLDTFVFVAKLRGKEAESHCVLKLPYGVKFGVISDQTLRELRTKGPLPPMEQSDTKARPKMTLAAAEEEAVIGDQPNFVITGSTPNTPRGHVFSLKAHKSPPTKPTVVERVAPFWKATTAATTTTTTERKLKLEEDDDDEGDEEGEEGGGWSNDYEQLPGEEGGNVFPLTDDGRGPAQLRAKTPPAAGGKSVSQIGRSNAVGVGGRRLEEGTALFMPILLAVIAFFAGCPTEICLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDF9</accession>
    <name>A0A914IDF9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDF9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9830.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9830.t1"/>
        <property type="gene ID" value="Gr19_v10_g9830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF118">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038093089" evidence="5">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9830.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19057" checksum="375C13E489C87BFB" modified="2023-02-22" version="1">MLWHHSRVLLVVFLSICCTQFGDVHARTQSVAVEGRLLCGTAPARDVRVKLFDEDLGVDPDDQLDAGYSDSNGNFKLAGHTSEMTNIDVVFKIYHDCDDGIKPGSRKLKFVIPNSYVTEGQTPRKTFDIGVLNLEAGFKGEERELIVTKKRRSHGHHRSYYQDIADFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDP5</accession>
    <name>A0A914IDP5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDP5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9898.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9898.t1"/>
        <property type="gene ID" value="Gr19_v10_g9898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9898.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17437" checksum="10F4E036D68CBE84" modified="2023-02-22" version="1">MSSQPSFPPIYPPISQVMTRNKCLDILDQLGTYMRTKNANAIKHIGEILTELGLDHITAAFLKWLEQKLICQNCGNQVGNPDELCYCPNAAERCHHGTSCCNMHENLNYYELLGVDERAKTPINRERMRGYHPDKEIRTAKPCPGSSQRPRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDX5</accession>
    <name>A0A914IDX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9711.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9711.t1"/>
        <property type="gene ID" value="Gr19_v10_g9711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9711.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="20117" checksum="14D8823D038B0DFF" modified="2023-02-22" version="1">MVPRKLPDCLSLLPPICFHVFRRMNLDPKIYWEIIWYRIWPLIEDNIYGLDLYTFQHAPRGWLSEGIFKSTDPVNFIIYLFYWTGGGIVPFELQNIFTGKRLVFRHFEKDNWLLVRCPIERDEAKWAEWEEAAAWNLCKWNCIGIDFEDSDIGDGLLDTNEGPVNRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IER6</accession>
    <name>A0A914IER6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IER6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9550.t3">
        <property type="protein sequence ID" value="Gr19_v10_g9550.t3"/>
        <property type="gene ID" value="Gr19_v10_g9550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9550.t3"/>
        </source>
    </evidence>
    <sequence length="690" mass="77076" checksum="182807698AD11B1D" modified="2023-02-22" version="1">MFMTSLWPFMKILDKTVAESFYGLVLALYSISQIITSPLLGYWSNRIERLKPPLIFCNLMMLLGNILYLFVELFPTHHYRYALCTSRFMAGVGWAQLGLLKSYVAAASLVADRSRATAFITGGFALGVILGPALQTLFTLVNYPGFPVCFVNRYCINISMFTVPAIFASLVNVALMILLMVRFRESHVGIIERVNMVNETLQIKKSTKLPPYDRCAVAVCFALRFTQFFVFTIIETIGTSFAMLMFNWSPIEVVFYDSMAHAVRGVVALLVYVAYIIFDLGKIVNDRIVCLLSLVALLFFYLITHTWPFLPEHVRLMNSSFVGNSSANSGGCNLNKYAWCAGLPRVNPWLYYGAIVLLIGPAFPNINVAMNTLFSRIIGPRIQSTQQGLLEMHGAIGRLIGPLLISFFYLSYGVPIFCRQPPTTVGGGPNYQFPDQQRLFVLISGTFRLIIEILGLPMNSFLAFITLKNKELWTTSGILLAIVALCDAIVSSSPFILFYFAITGNIACILSKCMPNFVGPYGNVVGKISLGFSVMIIACYLLLFGFIKFVYKATHKNSQETAQKILKSLTVIVMIYLAGWVATQIIKYNQQFFLPPNLLSQVLSTTSGAIIALTEIITAPVLYLTSKMYRKIMQKSLKHLNCATYKFSLNYQASIKVQPMQNVHISRHPPTFALAKKSNNNFNLCLASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFT3</accession>
    <name>A0A914IFT3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IFT3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9846.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9846.t1"/>
        <property type="gene ID" value="Gr19_v10_g9846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037963974" evidence="3">
        <location>
            <begin position="29"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="380"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9846.t1"/>
        </source>
    </evidence>
    <sequence length="763" mass="85734" checksum="E43424066E961803" modified="2023-02-22" version="1">MASSDLTLFNLATVLVVLLIQTVQFSGCQTNESLLPSPTSNASNELCRTIEGTKFHEQCLQSEVVKQKGFIPRHLRPPWLNVSLFEDNQLPEEKALGNGCYACYKGTTASYGVNPDEEYCACAFNYGAPNKKFGKIFGTFKVDGSTCLEDFHKMALMPTCGNEYYDYVKHCAMVHFYKNEPDKKPDDFRHKRTLVLLDGCITGASHNCTANVTIQFAEPPKALSIDSCNEENKTVFESTIRLKESSGKHAIGAASTFTFPVEFKHRLCVSWLQFAKLRALPYYELITVIISGDCGTKNFSLPMIESFRGRVQEMRGLHLDLRGEAAQWRDQFGAYDFVRHNDLNWQPTDLKLINNYGKPNPELMYPNFVLKSIGHASFSVDILKMFYHYNTVEIYAKNVILSPLSAAIALAMAYIGARGQTSVELGKVLAGASRCNSCDGPSLRDNYSKFLQEIGATQTDANFNLKISTKLFLADSVKVLDEFKLAINAHFGEDNFELIDFRQQNEVAKKINAFLDKASPGGKSIESIKPQSLNPTNTKLVLVSAINFQANWLQPFDPQYTEKKKFVLINGQEREVDMMLQIGEFMHSEEEEFELLGVPYVDEKAHFVILLPKGHFFGLEIVLNTFNGAKLMEFVVKSAMKERKVILPKFKIESVHHNLEEALLLLGIKRAFRPSKADFSGINYNNLSYTLYINKVIQKTHISIDEYGTTSASTAVPKSVDGSFGSNHEPAETPTFQADRPFAFFIILNKKHVIFSGIFMGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ11</accession>
    <name>A0A914GQ11_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQ11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10280.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10280.t2"/>
        <property type="gene ID" value="Gr19_v10_g10280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036802552" evidence="2">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10280.t2"/>
        </source>
    </evidence>
    <sequence length="187" mass="20611" checksum="07BAB2F62A5D6574" modified="2023-02-22" version="1">MLHLKLISSVCFFHILLFQNVNSLDDAPDTDSQSAANYANSSTVTRPAEASYTHRIIDDQQAQNTAAMPSTASHTLISGVGQVLAPFVPAQLRQRLLGRQQRGQIVPKQPELIVPQQLTQNVPGQPDQIEPQSPQKAEISPSNASSSTSNLKDNNNNILLDVIIQSKQKQINPQLRQRKKFSAKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRP1</accession>
    <name>A0A914GRP1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRP1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10125.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10125.t1"/>
        <property type="gene ID" value="Gr19_v10_g10125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10125.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39069" checksum="4F73C0236A588E2D" modified="2023-02-22" version="1">MEAIFICADVWHGVFAFLDPFELGLKVALISDRLDILVDVHFKSREWSLGSMEIRRAIGGNGAQIVVKRSGERFGERLPIPREPIPKNVIGFECIWISSNNQRRSWEIIRQKIWPLVNDNICRLTSFRLDHLRQFSPAILCNCPNLQLIHSFDLFPEFPDEDNARASSAQAMAKWLITPRGDGLPKMLECFYSGRMERLKGSFVNASESANFIIKFRENYPYVEPFELKNNLTRERLTLRQIDKDKWLLVRCPSVREEDKWTNWEEEAIEWQCGRQQNCIAITYSDRDIGEGMAEANDDICGSDICGPDICGLRQNRHLRPDICGPDICDPTFAAQTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRY9</accession>
    <name>A0A914GRY9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GRY9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10631.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10631.t1"/>
        <property type="gene ID" value="Gr19_v10_g10631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF27">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="81"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10631.t1"/>
        </source>
    </evidence>
    <sequence length="439" mass="48425" checksum="09EAD6EBEB3AB433" modified="2023-02-22" version="1">MFFFPLLGRLIPCFGPSSGVLRFSSPPLRRLLRRLSLLLFLLANRIVPTSPSASDYSAVLTPKSSSSSVLDNGVVGDPQVDCLEDRIRLTFRTQRPFTGRIFVKGMVENDKCVKNYQQNGRTQSDFELTNGQCNMRRSRKLGPEQRGVEQSITIIISFHDIFITKVDRAYRCTCFYMEADKVVTNRFDVSMIPTTELIDTARMPLCTYTVRRGSVNGPIVTYATVGEPVFHVWSCDSDMFSMLVHNCFVDDGAGKDRKPLVDEHGCTIDPVIVSELTYNSQSNLAYSEVNVFKFADKVTTYFQPPRCGSGPRRRRTIDKSADGAANATALPFPADDPFTMDLAAEKIVVLDLDDSAQNEENESGESAKGRAVLAAAARLGLPQTSQNQFAMPGTSVVCLSQPFVGVLCSTVAVIVTGTSIATALLLCRQRRKTKINGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS86</accession>
    <name>A0A914GS86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g109.t2">
        <property type="protein sequence ID" value="Gr19_v10_g109.t2"/>
        <property type="gene ID" value="Gr19_v10_g109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g109.t2"/>
        </source>
    </evidence>
    <sequence length="147" mass="16494" checksum="9378A0080EC577B7" modified="2023-02-22" version="1">MIKHNAKRQSNYRIMKWQNCCSDESTFVAVPCSFRQTGNVRLASAQPLRASIMQQTQIAPREGRRCERHKSCQKGSSRPSSISSLTLNRISWALTLGVTVANASTMCTRQEDSDIAHMLYKCSEGTGQSMDTDGQRRIGRTYCINVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GST0</accession>
    <name>A0A914GST0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GST0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10059.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10059.t1"/>
        <property type="gene ID" value="Gr19_v10_g10059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038114342" evidence="1">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10059.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8416" checksum="7DE97E34C6206FBC" modified="2023-02-22" version="1">MSSRLCLCALMCIILCIFLAQICQTLPTTECQKSKNKTEMANQMLLLQYFFARGIAFQPTGGDDSSTVDELAVKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSZ7</accession>
    <name>A0A914GSZ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ELMO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSZ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10475.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10475.t1"/>
        <property type="gene ID" value="Gr19_v10_g10475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO armadillo-like helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="576"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10475.t1"/>
        </source>
    </evidence>
    <sequence length="790" mass="91411" checksum="E0F35DAAFC0F76E8" modified="2023-02-22" version="1">MSNFHLSTKVLNYIDTRPKENEVKGAIKLDANLRLFVKNERSNGRDKSRKEMATNIYATLDKQEPLSTFVAQISATLCLTEPPENYALMFEERCRFLTEYNKNNVPQGFFLTLTASPSNYAKHFLAHFGEMSPSNRRLNGVLRLAQIIEGFSDEWHSSELNSPPLFSLMRSLLTIMQHFPVLCPWNDISPQFVHKMALFVNGQSKLEQNDSRALALGTLLVLVERCDHLHECLWERLSVESLIRHLDNADERISLSSLSLINAIYELADRGERLAIIKILHERPFIAAIGRTLEKTRKSQPNAAAASSDQRELWKQLERLQHIRFDEVRALSFRIPSEKEIDYVLNGFIDGDDENNVYENASVTDQSADRSEFCRFVRSTPPGSLAVCALLELTRPPSPPHDGGSFRRSSLVTSAQLHQMSCSLGRPFWWPLVLAKLVEILIKILNICCPFSDSLVNPRHLPFWRLVLNNERPFYTLFQVFVELFQRTWGEMHAKFDDLAKVLSVVQDQMERAIEEDEDSVEQLEGELLRKKFSYFGMQKIWKKEEMEKEELELSGAHIQPLRDHLRPEFERMVLQLRINFLRKGLTFKRLFPQRLNHQQNNSNVQNGNNLQQQSLSNHFWFWRLDDRQRHFHFWDCRMSGGKHSELALDTQKKLAISQIRAVYHGNDLTVRLVQQFGTKVHKKAQSLFRCGLCLELEPGTGEESEYFLCSAGDESEFVHWLEGVQCLLWPQNALQKDSVKEEVDRLLSLEVQVRLMDVQQQNGVEEMPSLPVPDWPTDFSWTPTVSAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT51</accession>
    <name>A0A914GT51_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylglycine monooxygenase</fullName>
            <ecNumber evidence="3">1.14.17.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O</text>
            <dbReference type="Rhea" id="RHEA:21452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13486"/>
            <dbReference type="Rhea" id="RHEA-COMP:15321"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
            <dbReference type="ChEBI" id="CHEBI:137000"/>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
            <dbReference type="EC" id="1.14.17.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="13">Binds 2 Cu(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.17.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GT51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10508.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10508.t1"/>
        <property type="gene ID" value="Gr19_v10_g10508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004504">
        <property type="term" value="F:peptidylglycine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.310:FF:000005">
        <property type="entry name" value="Peptidylglycine alpha-hydroxylating monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014783">
        <property type="entry name" value="Cu2_ascorb_mOase_CS-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000720">
        <property type="entry name" value="PHM/PAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00790">
        <property type="entry name" value="PAMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00085">
        <property type="entry name" value="CU2_MONOOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0186">Copper</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038056410" description="peptidylglycine monooxygenase" evidence="15">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="16">
        <location>
            <begin position="44"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="17">
        <location>
            <begin position="187"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="210"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10508.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38467" checksum="D1240B0F89FAC7E4" modified="2023-02-22" version="1">MIRLPLGNILLPILLSLLAPHNHGQLSLPSPAFPELPEGVNAADLRMPGVSPQMNESYLCSAFPLNSDRDHFIVGFEPVPTSHHIHHMIVYGCELPGSGDEAWDCGEMASSRGRYSHSPVCSSQPDIIYAWAHDAPELILPEGVGFRVGGSSTAQFLVLQVHYMRAAKDDTSGIRIIHTEHPQPREASTLLLATDGRIAPTKNEQLEVACVVDEPAVLHPFAFRVHTHRHGRKVAGWTVQEDPISGKDRWTMLGQRDPQLPQLFQPVANQSIIISQGDVLAARCTMENGEKREIKIGPTGEDEMCNFYLMYWTENGQNLEQNACFSPGPPVYRWTKNAGLNHTPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT92</accession>
    <name>A0A914GT92_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT92"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11157.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11157.t2"/>
        <property type="gene ID" value="Gr19_v10_g11157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11157.t2"/>
        </source>
    </evidence>
    <sequence length="76" mass="8516" checksum="55A6CAC47812C6CB" modified="2023-02-22" version="1">MLAVGGPLHGLSLYIRLFPAKRHFRHFDTGLFDTGLFDTGRFDTGLFDTGLFDTGLFDTGRFDTGLFDTGLFDTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTI8</accession>
    <name>A0A914GTI8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11129.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11129.t2"/>
        <property type="gene ID" value="Gr19_v10_g11129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011:SF6">
        <property type="entry name" value="HIGH ZINC ACTIVATED NUCLEAR RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="439"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="514"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11129.t2"/>
        </source>
    </evidence>
    <sequence length="1024" mass="108575" checksum="754DCEACEB8877D7" modified="2023-02-22" version="1">MADLVTTNSAGPSTSGGEDQLQKAQPANVCVVCGDESDGRPKAMTESKQYASSIASSVSKQASSVSKQASSVSKQAVLASKQASSVSKQASKQAVLASKQAVLASKQASSVSKQASSVSKQASSVSKQASSVSKQASKQAVLASKQAVLASKQAVLASKQAVLASKQAVLASKQASSVSKQASKQASSVSKQASSVSKQASSVSKQAVLASKQAVLASKQAVLASKQAVLASKQSSKQAVLASKQAVLASKQASSVSKQASSVSKQASSVSKQASSVSKQVSSVSKQASSVSKQASKQAVLASKQASSVSKQASKQSSKQAVLASKQAVLASKQASSVSKQASSVSKQASSVSKQASSVSKQASSVSKQASSVSKQQASKQAVLASKQASSVSKQASSVSKQASSVSKQASSVSKQAVLASKQASSVSKQASSVSKQASKQAVLASKQASSLHFGRFTCRACAAFFRRTVSLKLQYKCKRQGNCEVDKAARNMCRACRYQKCLQQGMLTTAVQHSRDGIGKRSRSGQRERVFISSSHTPGDAKMPRGTSETKKQTQFLGIGYGRAQSPSSSSTILLDQASTAATILQLNAVSGQISTTSTFGPQQQHYTGEFGGGVLPPYIMGNFPNLLGQQPAGGSVNLGGHGSLQMTAQLQQQQCTSSAVAVELKYLRRMLDGYHHFLSLRKASYTLVDGFPLSRRDNEDCPQSNFGTSKKICKIEASLIMDIVEKFFHPFSQLPTDDKHKLFNTYYCLFSNAERAFRTYKMFGADDDRLLMPDGGYVRLSELQKFYENNTLVRGDPSQVAKIFENAMHYLVKTVVAHMRHIELSEMELIALFGIFIWSDSEEISHESLQTALQGLSEAEVTLKTANVFLLIPKLELSVKLMMENFCISELFNLMNLGGGACNSKGSITMIRDRAVGLPPPLSAHSSPLSRRLPRCVRVQHDQRLLGLPGLKSPVVSRRRGRKAKRLYVEVLLKMDRRCTFGTGKLGRVTPRGAGTSSGARSLAAAVVECAVLWPVLFGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTT4</accession>
    <name>A0A914GTT4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTT4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10343.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10343.t2"/>
        <property type="gene ID" value="Gr19_v10_g10343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000032">
        <property type="entry name" value="Glycerophosphoryl diester phosphodiesterase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="4">
        <location>
            <begin position="67"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="5">
        <location>
            <begin position="408"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="774"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10343.t2"/>
        </source>
    </evidence>
    <sequence length="889" mass="99569" checksum="1B096966DF4FE063" modified="2023-02-22" version="1">MLSISSQCIYSQRCRRLKPSPLPVSSISYLLLKCSYKSSALVVLAVTCPKKNITKFSYFYESTKFPIAGQPMFTVHFDVSVSFALHNDQFVFVTGSHEHLGNWETGKALKLDKRENGRWVGIVNLGVDILKFRYFVGYFLQSEEGRSPVLAISKWETHSTPRCVMPPVEASNKGVCRANLRDIFGFSGGREFFSDGWVLTDEMNQILLTVSGGALKFYKQKHIRADYRLKVVPFDLRNRNDASNAEDDDEPNAVATIDELPSAHPTLPSHSPTEIAGLKNGVIGLQQPKKKSFASDPPKFRDQDEFGEPFHNKVDYFMFRTQSVAVEYLSFRIEVYAGTVDKLVAQGYALPSTLHDSFGRTSVPLLTKMGIPVGKVYFAYLFIRPLRLPHPNPTMHNCYAKHWKKRSTLEVGHRGMGNSYTKCAVARENTLHSLNSAIKNGADLVEFDVHLTKDKIPIIFHDFHVMVWVAKRLPSAASNAAQTDSESDDGKRPKDPKVLDFYQLAVKDLELNKLRLLHLDHVKVNENGMDNGTDSACHRRVTGAHDEAEEHRPFPALSEAFQSLPDVGFNIEVKYPQLQVDEQNECEGGYFERNEFVDIILSNVLSNAGRRRIVFSSFDADICTMLSVKQKKYPVLFLCLGDSTRHVQYADERTRSSMAAVKFAHAIGLVGVNFNSEDLLKDASPVGKAKELGLISFVWGDELVERKHVDYFKKSLAVEGLIYDRIGEGESRTNVFTLEKAKKNELFSQKKSSTAGVMQATPPRCFSHHQLNNNNIAASDGEGARQRVARGSRNRSTSAWSSTQESDGDIRSKNAMFAIGEIDSSFSSVPVVPTIRRHNSSYVGTPNEALGHLQTVVESRVKTTATTVDEGERSETIKQQRFTMMASEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTT6</accession>
    <name>A0A914GTT6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF155 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTT6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10702.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10702.t1"/>
        <property type="gene ID" value="Gr19_v10_g10702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="288"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10702.t1"/>
        </source>
    </evidence>
    <sequence length="853" mass="97054" checksum="F22BB8AE97C2A455" modified="2023-02-22" version="1">MGIDLVAAEKEQNWTGRRRITNLMDTTFVMTPRKWWGDAIIHEIIYWSAFVGDDARGVKTIAEGKGAEGGSESCTRTEGSHSAVEKGRVQPRPSAWLCPNPTPSSTNNILLCCPFPPGVLRTRKKGEGVLGDGQSAHRVRPNPLVFSYADDDGSSILRILEPAGNTMLMISVKRISLGGCRFALLRSKWRQCVTCFIKIDTVQQKTNRNRRKRPLTMLFKHKQNTATTTLPEVNCVPVAECFDIDAMCKDAKFTNFFTFNYVDDNKIAVYCRQKVFKMREAKVYGDFFVFAEGVVVFWDVGRRSQAFIGNILSKYQHNPFGDQLKKDEEETMAIDFTSFSGSSYASNDVVFLNSERHHRQLNAGESAGSSNSEWAFGSKRLMKLDDKVQGCIDGMKNRNDRWWRFLKRNGIPWDHKKALQMIGCFADLRHTVNSTDLLSKDVYWDLPEIESAYGSLARRLCLQSRRNWVNERLGHCEYFSKTISEALNTEHSHFLEVVIILLIAFECAHVATNWLGLGGQEVRAKVVHRAHQNGHEVNDVLMEDVEEAGEGTSAQQQTFGSDQNRRLAFIQTTARIKEELRKAEQGQTSGQTIEKLFEQVHRSNVDIDNVDNFRTLCRGSEALDQLIQLSVSQVEGMKDETAHSFDPGKLVARLKSFAIAHRKTEDKDHFTTIGRHFNFLLRKTPNFSYLRPCYEMKADGPHLREKTQRKRTTQPVKEETQIVQGKTLTEMGEAAAAASTADDGTGGSSTAVNKELDNVRRHLKRVYKQNGTDAVDYYRFVLHPNSFGETVRLRVDPCTGLASIVKLSHEEREERRCVERSKTQTVPRLDYDTWRRMVCELKIDKPYITRRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU51</accession>
    <name>A0A914GU51_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10423.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10423.t1"/>
        <property type="gene ID" value="Gr19_v10_g10423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10423.t1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37930" checksum="B831F917BBAE6A59" modified="2023-02-22" version="1">MFPYEVFLDICKFLSRFDLLTLQLSSRRLRQFVADNAFYWPRHRCYRLTFLEFFAINTLCRAENLSDFPVDFSKKLSDRLSALQFAPSEDRVQLFLNETEPTFLLFEFTSGRKFYVQIGPFITSQNVANLVFWLQQISDVFFEEEIRGMPKFSAQFLEWIRRNEFAQIIRLRCKTFGCYEFEPFDQLDVQFNLNYLQAELMDKANGTIFSSELFHLLFNGAPHIKSFSTRWVMNCGTDFTDQLIEHAANSTNPEKMIPSIRFTPSFHRQRELPIPARSLVPSAAGNVKLIKREEVRFRVVLFIYNDAETGEEAISQFSITNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUE9</accession>
    <name>A0A914GUE9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUE9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10885.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10885.t1"/>
        <property type="gene ID" value="Gr19_v10_g10885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10885.t1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60364" checksum="E05732D6CAD5A5D4" modified="2023-02-22" version="1">MPVTYSRRTYSTTNPSTYMSDAITPAGPQTLSAKNTSKSIANSEEILEQLDDVDEHSNFENDDVKLQAPLHNDVCLQNIDKNSMAPLIYNAHQPGITAVSASLPKKQCLCSRNFNIHFHQSHNNDINNNNNVWRAWKDAMFFDLRTNSECQRLCVCTMAGKCYMPNENAKQGGISVRFSTDCSVSPCLMRAVLRDSAHSTNGCLVENGDKKCAFHVGQSFDAVAVSCNGCPSQKVERLDDEQCPKTLAEASAQVEAVKVEDGSHEGAVKLEPITLIKQNIIRRSDQEDVQEFTDKKDSNQSSDTSEKNRKIFSKKDKEKMVDRFEKIKNKYPQMSNEKIAQKLGVNRVTLFNWRKLYQAGYKRIHKYSSSEKNKIIKKYYEMKEEYKRTKSDLKAREIEAKIVMKLGVSKRTLYTWRHNKGLTGQKSLSKNEKCKIVKRYVKLKKQNPKMKMNEIANTLGICKSTLCEWRKLCQPEYKHFYNLSTEEKTKIIKEFDEMKDEYIGKKSGLKNNTKLEKQIWLNNNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV18</accession>
    <name>A0A914GV18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10662.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10662.t1"/>
        <property type="gene ID" value="Gr19_v10_g10662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10662.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44777" checksum="2A90BD094CD84E0D" modified="2023-02-22" version="1">MVKDKKYYEILEVHVTATDHDLKKAYRKLALKYHPDKNPNEGERFKLISQAYEVLSDAEKRKIYDEYGEEGLKGGGEGGGMHNPMDIFEMFFGGGGFRGGGEKPTKVRDTVHQLTVSLDKLYNGCTKHLRITRHILCPKCNGVGGAKEGMKQCENCRGRGLEIHNVQIGPGMIQRIQKACSDCGGEGEINRNPCKHCSGKKRVKSEETIEVHIDKGMRDGQRLMFYGKGDQQPGLEPGNVIIVLDEEEHSVFTRKGTNLVINMNLTLTEALCGCTKHVETLDKRILSFTQLPGEVIKHRDFYVIQGEGMPTHRHPDQKGDLIIQFSVDFPDKLPLHSKTNEQLRALLNDDEAKPEPSVSSNANTKTIHLEPISEAMLRRRAHEDEANNGEPQAVRCNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV86</accession>
    <name>A0A914GV86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GV86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10715.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10715.t1"/>
        <property type="gene ID" value="Gr19_v10_g10715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF250">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="201"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="311"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10715.t1"/>
        </source>
    </evidence>
    <sequence length="573" mass="64989" checksum="F16E92DDD6342EF9" modified="2023-02-22" version="1">MTPAELEQFDCAAASGVFRPLLIGKTGGEISFIDDEDEDGDSIERLPPSPSSTSPSRPPPNGPISPLTIRRTVSLLPTLSRPIEKRARKTTVFKISLATVADDGIKYANRRKRPWLQPNLTKFAVENNYLRTKSSLVERNLVDTNGEPRMISKLQKTTKFWPYEIWRDKFLREHNCWKEELCREVFLSALPHFVVLLVVSIYILLGSLIFRRLDEQLDKLPFHDVLLFTFTTITTIGYGNIAPRTPQARLACVAYCLVGIPLVFLPLSNLGEVLAEFYWIGIASMKGQKDDGHFFHRGGANRLPLKVVVLLILFHSLLGGLIFHFWIQRMPIFPAIYFSFISITTIGFGDLFPEPQNLFETMVIIVYLSAGIAIMSTLFNTLGDHLRRIHYLGRDFEGAPDVRVWFGGQPLTVRELVALVANRFEIPAERLREVLAELDALIRLSDHGTHATRSRHFWQNAEQKMDEQLQPPSPTSSINSEQQQMLQALSTLHRLTVKGTRTFHTPSLNSLSLLIRSSPNHNQNISSSPLIMYQFLTNCGRLAMSNKFTKFTQKRINRQMVAFLMSIISVQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVL8</accession>
    <name>A0A914GVL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10810.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10810.t1"/>
        <property type="gene ID" value="Gr19_v10_g10810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039470">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36300">
        <property type="entry name" value="RAW, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36300:SF1">
        <property type="entry name" value="RAW, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15891">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10810.t1"/>
        </source>
    </evidence>
    <sequence length="661" mass="75322" checksum="781135DE711B7F37" modified="2023-02-22" version="1">MNPKSDRCSTLINIEGSADQQPLEQPPDVPVYDVFLGGSCGNTCWRSDIVIPYLKKRAISYYDPQRPAWSENMIHEEQQAKENSRIFLFVLDPGTINATSFLEIAYLAARKASKLVVVFLGRHEWSDKALRVDLPDRIRTCNLLEAILKRHSVIMLTSIDQALDFVDAKIIGGKRWTDALRKPEHRLPFLKLRARRCAARCKSRWRSTARQCRARLATHFKRFALLLLFETFAVMGIAFLLSTNALPLAIPLWAIVLPLLAFNYMLLLSLIIYYKFKSHKRKKKVQRSLQLPVPPLPRVHTLPESLASIATQQQHACTASDRRQRSFRCAKKSSEHSSSTASNSGGDDGAYGPMIELLISGSTNGSSATAAGKKFKQSSNIFKEPRRNKKRVDSCPFDRVRLNGCATSPVGYDVFLSCSSSSELDWITQKAVPELHKNGLSYTSALMVDNEMRIPFLQTATHILYYIPSYKTFLSGMIEIAYFIGHSDWQVTVCVPREAECLVLLEDVAMLDPEIRRAVERRNECYLMAFSYLKDMAAQRQIRVFTRVADAIRHIRDATFLEVQQQYDAKMGGNTTETDQHHPQQQQQQQQQQQHNHQQKRTALRQIVEKQHLVKERTSQNLLAHLREATARGQKLELDLAEIRPDGSMTIDLNQLRPHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVW7</accession>
    <name>A0A914GVW7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium/calmodulin-dependent protein kinase type II</fullName>
            <ecNumber evidence="4">2.7.11.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Uncoordinated protein 43</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Dodecamer. Subunits are tightly packed around a central ring-shaped scaffold with extensive contacts between the regulatory segment of one kinase and the catalytic domain of another enabling cooperative activation of a subunit by the adjacent molecule. Interacts with and phosphorylates daf-16; the interaction promotes daf-16 nuclear localization. Interacts with egl-2 and tir-1. Interacts with nsy-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVW7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1168.t4">
        <property type="protein sequence ID" value="Gr19_v10_g1168.t4"/>
        <property type="gene ID" value="Gr19_v10_g1168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14086">
        <property type="entry name" value="STKc_CaMKII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000009">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000002">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="47"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="443"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1168.t4"/>
        </source>
    </evidence>
    <sequence length="878" mass="96884" checksum="C420C22083E1FAE7" modified="2023-02-22" version="1">MVVNPISSRMNNNASNNQQMASAVANSPAAVAQQQLHAQSTKFSDNYDVKEELGKGAFSVVRRCAHKTTNMEYAAKIINTRKLSARDFQKLEREGRICRKLKHQNIVRLHDSIQEEGFHYLVFDLVTGGELFEDIVAREYYSEADASQCIQQILESIAYCHDNSVVHRDLKPENLLLASRAKGAAVKLADFGLAIEVQGSSESWYGFAGTPGYLSPEVLKKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKNGAYDYPSPEWDTVTPEAKSLIDSMLTLNPQKRITADQALKVPWICDRSRVASVMHRQDTVDCLRKFNARRKLKAAISAVAIVNRMSHCMSPQGSRTASGSPTATEPPIPICPSLSSPNCGSTPTPRPIGWKVEGPLQKVLKSHHTSTGGTETDTTSSSSDHAPEIGGAILTTMIATRNMSSRNLLNKKDVPPSTIKESTESSQTIDEPDGVRSAGGDKARIQHENTVVERVLSNSLATKAVTLPQPLAVVTGAAAAGPAFGVHSPLGASAGTSSPAPPLASCASPVLSGGCFLCSYQQLGLGLLFDKMLKGFVPLGPVVNSENHIDQSPLLHHTSPPTDTNSKMVSTTKTQKQEIVKLTQQLLTSQDFDSFSKLCDPNLTCFEPETLGNLIEGMDFHKFYFDNGPQIPLGVTTAGIKHHHHQIHTTILNPNVHLLGDEGACIAYILLTQYIDRFGEARTCQAQETRVWKKRNGTWHCVHTHRSGEIPSATGPSSCIYRQSLQVCDSQIQQFKRKEWFNRQKNLTECAEVFRLEENWREMMGWGEKFTGMFGAKIYTDSPRMGGMGWDFGFRVLLMRVVVFAILPVDFTSIMERHYSSICVTRDEEVNVIPGFDMAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW08</accession>
    <name>A0A914GW08_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW08"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11711.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11711.t1"/>
        <property type="gene ID" value="Gr19_v10_g11711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11711.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11360" checksum="494FD29F94528668" modified="2023-02-22" version="1">MSTLSVGGDSQKHNGTSGVHAAAQQQQMTAMAAAVPVVAAANGRNFGFFVRIYLVGILSGHFFLEPCPTIFLDCMKSSGCTRERGARCATAGFSNARAVFACATLQISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW27</accession>
    <name>A0A914GW27_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SGTA homodimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GW27"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1187.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1187.t1"/>
        <property type="gene ID" value="Gr19_v10_g1187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000732">
        <property type="entry name" value="Small Glutamine-rich Tetratrico repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1187.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="36919" checksum="158DB8951D4D9F20" modified="2023-02-22" version="1">MQSEEKQKGRVTNDERNLVVSFIQFLRQKVSSNQCTDDQIEGLEVAVQCLETAFSVSDKNYAFQPSKPLTEIFKAAEGLPDGDEELPTPTQAEIQKSNTLKEEGNELVKANKHEEAILKYNEAIKLNRDPIFFCNRAAAYCRLEQYDLAIQDCRTALALDPNYAKAYGRMGVALSCQNRYDHAVEAYKKALEIDPGNESYKNNLSIAEDKLRQAQEAFANNPQPNPFANMFGGPGGLGGLMNNPEIVNTFSNMLQDPNMRNMMSQMMQSLNQGQGGPAGANGFSEMLRAGAAIAQTMEQANPELVDVLRRQFGGGGGGGTDGPPGGNQNNGQQPPPGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWE0</accession>
    <name>A0A914GWE0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWE0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11015.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11015.t1"/>
        <property type="gene ID" value="Gr19_v10_g11015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="110"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11015.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31642" checksum="1B80A4F345395E30" modified="2023-02-22" version="1">MANIYDEFIIVDEKSVTDFTDGRCSGGCYFRFDRTTFAELEFTMVNSQRGLQIKDIASHPTDESEPLAQIVSWKWDKGTQKIAKTVTLNRGQTAEIMIENPCPPFSSPDDDLTVHIGDRQVTVSAHWLMVVSPVIERMLSVEMKEKQQRTLNLDGHGITMEQFMQFLETVNDHFQHGRSLPNPTNVLVLLKLADYFQIDWLKERCEAHLINCVEIPLIERFLLIDRYRLNNLKNFFLRCLNAYTLSEFNHEQLLATISKEFSDQLTFRLSAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXB1</accession>
    <name>A0A914GXB1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ankyrin repeat and FYVE domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXB1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12059.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12059.t1"/>
        <property type="gene ID" value="Gr19_v10_g12059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15728">
        <property type="entry name" value="FYVE_ANFY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049764">
        <property type="entry name" value="ANFY1_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="580"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="814"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="847"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="880"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="1013"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12059.t1"/>
        </source>
    </evidence>
    <sequence length="1083" mass="118929" checksum="B7883344BBA8B027" modified="2023-02-22" version="1">MSADVGIAHHLDLLRKEYVRLQVKHAELQRSYDVLSSINALDCAEGIRIAQNASTSNFLQRLLHIVTQLYDKDLYSDITIHVDGHQLRGHRIVIAARTDFWGDLSTIERLELTEIPCNVAKVMMKWIYTNFLDEKIGDAILMPLLETALKYRFEELKSRCEEMIIARIDVENCVGIYQFAELNSLDRIRDFCAEVVSARWSDFTPAHFADMPAQLLYRLLKRKSSNLLGSLIRLQREDVLFLFLIENDARLKDILNEFDCAGQLPLDIAFESKQLKTAKCLVLHGADLNKLDGRGNSFLWKAIRKGNVEVCDFLIENGTNLDYVHEASGDTLLHVLAKSKMLPISICQWVPGQISHFDVNALDRDGKTPLIVAVEHENVEIIVLLLQQSQLDINKQDKSSRSALEIALLEKHTFEIAKKLIAIDGLDLGCADKQTGQTLLHKATASSDHTAIQFLATNGVAVDVPDAKGSTPLHQLLKALPSDGAQQPIEESHLAILRVLLQFGADPSLIDVTSGCSSLHYAVSKPKERTGTTIRLFGADINEKSAGAIPLLIKAIAAKRDDISKFLLANKAIAAVTSPDGFTPLNLAVQNGLTSTVDQLCKLGANLNHPNPLTGLIPLWTALENEDFGTAEVLTSHGADTEGLSPNDEQTLDETLLHRAIDKNNQKAAVFLIKSGCNVNALRSVRDGPSSRRKPSPPSNDAAFVSELYARSKQTPLHTAVQWGLTEVARALISNLNCRIDAQDADGRTAAHIARQGPNKMAEAICKRLPHAALQMNGSGENLLHCAVKSSDLESVLFLLGIHIDVNIPTQDQERNTALHICSRVGDELILRNLILAGAEVNMRNASGQSAVSIATMHGHADICRALLENDADPNIANDDGNNALHAAVSRGAVNAIRLLLSESQVDTLAVNKRQQNILHLCAINIGHVSVEAFAEILKAQPNYPLEAADMFGNTMFLLAFINGNSELCKLALRNGACMGVMNNQGQTVFNFSTPTQQLLFGLLESLEREPKWAEGDSCSECVTKFTLTMRKHHCRHCGRLVCAKCSDQQIPILKYNLAKTVRVCEMCYGVLTMGAPPASQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXB9</accession>
    <name>A0A914GXB9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXB9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11621.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11621.t1"/>
        <property type="gene ID" value="Gr19_v10_g11621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11621.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22324" checksum="FDA06B4BDC7A89DF" modified="2023-02-22" version="1">MEEPDEYEEMVAVLQLDGVLDFEAIRRAVSASAIRVRECDKEAPIVQIGSHLYVGKWTQTLGTDMLFCSTMLDEYHHPTEQQGQQRLELVAMSDTRLCAQKVLLATDESSNNATQSRHEQSSSSSNAPPPGPTRIAASSRLIYYLWDLVRSFKNTTSYKMSECTGSASHSSASSRLRKRKKMKKRKMRREAPGDDVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY18</accession>
    <name>A0A914GY18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12253.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12253.t1"/>
        <property type="gene ID" value="Gr19_v10_g12253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12253.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15818" checksum="4E26AC6E2031AF22" modified="2023-02-22" version="1">MTLERTNNGMEAAHGQFARELNHHPSLSDFLASVRSQVDKQVDIGRAERLQKSTTRKPKYVIKELNVVRILDGANFDTDDGLMDAIDLLGLVMQGYVEGLLTFVEVKKVEMILCEMSNVRNVQCAKRLFSSQCAKCPFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYY4</accession>
    <name>A0A914GYY4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYY4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12628.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12628.t1"/>
        <property type="gene ID" value="Gr19_v10_g12628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="249"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="425"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="465"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="573"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12628.t1"/>
        </source>
    </evidence>
    <sequence length="730" mass="82651" checksum="A5818A45A170E695" modified="2023-02-22" version="1">MVGRLIRNFLNGQHIICKVQHVQTVRVAFLHQHSKNVCPAAVLSCGARMASTSSNRPSNRSKLSDKYSNNSGSTLLDDYHNNRADNLQLTDLGKDTVAFALDPQGSRFIQQKLGRARSTETAQLIINEISAQVTPLSLHKYGNWVIRSVLEHCTEQQKRPMLEQLLDNVPTLVTDKYGCFVINHVIEHGLPEDRERIARNLHENIISLCLHKYGNWVIRGVLEHCTEQQKRPVLEQLHDNVPTLVTDPYGNYVIQHAIEHGLPEDRERIVHILQDDIMKYAQHKFASNVILKCLICGTADQKKALIDNVCGGGPETLQNARQLMADEFGSFVIQKFFEYGTDDQKARLVDALRGHVLTLSLQIYGGPVIQKALKSVDKTSQIEIIEELTPRACVIRCIKDRYGMHVMNMIIELIEPQRLQFVVDAIMYSPTDSVAPLSLHKYGSLVIRCVLDNCTEPQKRPLLEQILDNVPTLVTDQNGNFLIKHVIEHGLPEDRERIVRSLHENVLTLATDKYGSHVIKHVIVHGLPEDREHIVRSLHENITSLSLHECGNSVIQSMLEHCTEQQKRPVLEQLHDNVPTLVTDPYGNYVIQYVIEHGLPEDRERIVRNLKGDILKNAHHKGICSVIEKCLVFGTTEQRNALIDQVCADNGSGNPPLLQMMKHPFANDVVLKMHDFADSAHRDKMMFAIEEHIPALLRLQTRQLEQQSLTKSGALVDKRKKSNNNGLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H042</accession>
    <name>A0A914H042_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloendopeptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914H042"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12814.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12814.t1"/>
        <property type="gene ID" value="Gr19_v10_g12814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF897">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="17">
        <location>
            <begin position="244"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="16">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="16">
        <location>
            <begin position="549"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="16">
        <location>
            <begin position="671"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="630"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="549"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12814.t1"/>
        </source>
    </evidence>
    <sequence length="706" mass="77749" checksum="1FDB1274A1C65CDE" modified="2023-02-22" version="1">MFCFSIFIHRRVVVRPPPSVQQKKLSKQYLSDRTALLFEPQWKKVSGQQPAPLPVPHKYMTLDSRPADRPLLRRLTVNCVQIIMLELMKMKLTFSVYVYLFTTMKIRRLTHNLTTISTLMTTTTTMLGIIVMMPSPLLSIKNAKKSSSPSLSSSSNSSHQQMLYDLNLPAYETVLTPIDFEQALELEDNPMPGSTDWDSEAMYSMEKFEGDIANDLNASTVALFIRGAPPEGTKGGGNDINQLNAIRDRRQLWRNARIPYALSSQYSSYSRSVIASAMQEYAKSTCIQWTPRTAVDNDYVYIVPERGCYSMVGRTGGRQILSLGNGCIQKGIIIHEMMHATGFFHEQSRTDRDTFITILWHNILPGMQGQFEKYSAATIQTLGSDYDYGSIMHYGPNAFTRNGLPTMVPRRQTSIGQRSGFSKLDAWKINALYECPAYGGSYASTVIPPAQPITTPPTVAMLLTTTPMASSTPRFCRNTRPDCDHLARQGWCTRNPQWMRDHCPMSCGWCSGEGANGRKPSIGGLPSPIPIVPATQSSSPAPPVPEPSCEDLRVDCAELAKRRYCITAPTFTSTYCARTCGFCFVPLATDMPAPQGAATAAPPVITTSTLSASSRSGGGAVGPTVHTQQPLVTFWPPPARPDNQRPPGAVTDAPPPQPSGPGKGRPPAQLCRDRKHFCAAWAKSGFCRGIFLSYMKKNCMAACGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H218</accession>
    <name>A0A914H218_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H218"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13274.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13274.t1"/>
        <property type="gene ID" value="Gr19_v10_g13274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13274.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22128" checksum="FC23BA2B5F895F49" modified="2023-02-22" version="1">MPFLASSSAEEPMSLASLITGSNCLKACGMEDIQHAARRASDLFATVRVCAIVLTSLLALYFVLLIALRVYNLNVRQKRSNGEEHFVRESNEKLKEFCPSSTSSLSSCSRPTPIYSHPQLSQSAAEFPHSHDTTAAATPMPMPPPSICRQYDKNADDGDDGSAEKPNLLFTQFQLGNSQKLHFNSLSDYLLAKRMAANAGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H444</accession>
    <name>A0A914H444_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H444"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13811.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13811.t1"/>
        <property type="gene ID" value="Gr19_v10_g13811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="6">
        <location>
            <begin position="523"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="783"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13811.t1"/>
        </source>
    </evidence>
    <sequence length="817" mass="91767" checksum="23AD240B974BA510" modified="2023-02-22" version="1">MGEQVNLAQILQQLTQALNAINGGNAEKQHSELFATINTQIAEFSYDSETDRTFATWFERYGPYIERDGQNLPDEMKVRLLIGKLGSQEYVRYTEGILPQKPTQISFKDTVTNLGKLFCGTKSLFVRRFEAFQLTKADHQSPIEFADQVNASCETAKMELSKEEVKALIFVSGIGDADRDLRERCLRLMEEAHLKGAQIRFAALVEECRTVLSLRSSAAALSRPIGPNTNSISVKPQRTTERSRRPLSRGQSRSPTRSNSTQSRTHQGSRPTPPSPCRWCNQMHWMSECSKRPPGAKWSRRGPVEKHCRVGNNYARGDNIQKRGSMSVLSVDGDTDSWLTLDCLINARPVSLTIDTGSRITIIQTQLWEKIGKPPLSTGKSQGKSYSGHKFELTGSFNCDVTYAGVTIKLQCYVSPDGVLNLFGLPWIRAFESKLRRPIATTLEFAIAPPVLATCSAPTSADELTALLKREFPIAFSPGLGHCNKMKAHLYLQSGAQPVFCRARPVPHGAREAVDAELDRLLEIGAIKQIDYSQWAAPIVAVKKKSGEIRVCIDFSTGLNDRLELNRHPLPRPEDIFSAIRGASIFSQIDFKDAYLQVELDEPSKHLVGLNTHRGLFQYQRLPFGVKSAPSIFQKLMDELIAGLPGVFVYLDDFVVASANHQDHCSTLRKFFGRLQEWGLRVRLSKCKFMCEQLKFLGHIVSADGIRPDPARSAAIESMPAPTNAQTLRSLLGAINYYSRFVKQMREIRTPLDELLKKDVSWHWGTRPTTRLRYGKADSPIGAAFDTLRPGQANHSRSGREQRRNWRNHFPHLQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5C1</accession>
    <name>A0A914H5C1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H5C1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14137.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14137.t2"/>
        <property type="gene ID" value="Gr19_v10_g14137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14137.t2"/>
        </source>
    </evidence>
    <sequence length="390" mass="43730" checksum="C5DA1F63CC6FA36E" modified="2023-02-22" version="1">MNLANFLTEECGHKVHMLVPIRDENGKLSDKDVEARLNIRYFSAENHTVPQKVKVKQDTVLPIDNIFLEIISDLALMDKLKAEKFDVGISEAFFLTEYSLAIFHILQIPATIATLTQPMWPIHLYLLGTLSKMKADNLLASIGVPTIPKLVNKITRNLHGDKLVEKVQEFWELCVTQTLESTKGHINQNTSLNNLMLNNGTARGIILISFGTNVDTDEPEHTQLFEAVIGTAENFPDILFILKLSKGHGLPIKRDNVVTATWVNQKEILGHPKTKAFVSHCGMNSVYESTFNGVPMVCVPFFGDQYYNSESLVRQHIALVVEREQDTDTIKKQLTVALTKTLGLEKSDGSEEHIDLDRVKSIGAAIRDNNVGKTICEAMKVIENEMNEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5Y2</accession>
    <name>A0A914H5Y2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5Y2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14487.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14487.t1"/>
        <property type="gene ID" value="Gr19_v10_g14487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14487.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14430" checksum="843BA8F3913463C9" modified="2023-02-22" version="1">MVRHYIRFFSRDGERVARHFDNGLFDNGHFDNDTSTTTLRQRHLTMSLNWRSNEWSSLSHKLCYDRQVQPSFGTKNNYLFYFSSLAYLVRSPLGQLLNPNLHLSIICTLRDGQNIIKKEFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6A5</accession>
    <name>A0A914H6A5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6A5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14217.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14217.t1"/>
        <property type="gene ID" value="Gr19_v10_g14217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14217.t1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44379" checksum="7781469B9844C8FC" modified="2023-02-22" version="1">MCTAHFFARRGYVRGVLFCAARFYARRAFLRGAFFCAARLCALRTFLRGAAMCAARFCARRIFMRGAAMCAARFFAWRIFYAAHFLRGAAMCAARFFARRGYVRCALFCAARLCARRAFLRGAFLCAARFFARRIFLRGAAMCAAHFFARRGYVRGTLLCAAHFYARRGYVRGALFCVAHFLRGAAMCAARFCARRGYVRGALFCTAHFLARRGYVHCAFFCLARQCARRAFLRGAFFARRAFLRGAFFCLARLCELRAFVRGAAMCTAHFFARRGYVRGVLFCAARFYARRAFLRGAFFCAARLCALRTFLRGAAMCAARFFAWRIFYAARLCARRAFLHCAFFSAARLCALRIFLLGAAMCAACFFARRIFCAARFFAWRIFLLGAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6A9</accession>
    <name>A0A914H6A9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6A9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14580.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14580.t1"/>
        <property type="gene ID" value="Gr19_v10_g14580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14580.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11058" checksum="F183F08EC29523D9" modified="2023-02-22" version="1">MSARFRQAFLRLLNGKKQFINSYKRESLCAQTANGTMTAAARRLRTRRSGSGPSDGSGVLLSRLTAADAETRATLMLRVQRNGNTSCHSIAPRAEEAESQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6C1</accession>
    <name>A0A914H6C1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6C1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13638.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13638.t1"/>
        <property type="gene ID" value="Gr19_v10_g13638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13638.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37184" checksum="18C3D1CC9ED0B846" modified="2023-02-22" version="1">MSDNVSTEKQQQQMKEIFICDDIWYGIFAFIHPLELGLKMALISDRLDVLVDVHFKSRKWSLGLLDVCRAIGGKGAEIAKSINSKRLPIPQGPVPNSVIGFERIWISYVDKSVIEFLQRIRRLFDSSGTNVSIPNAHEESPVWGIICQKIWPFVNDNICRFNLYECQFKRLRQFSPAILRNCPNLRSISCSTICPEFPAKDDADASFGQALAKWLITPRGDGFPKILHFDLSPNMEGLKRSFDNASEPFIFILTFLNVLSEQPFELKNTLTRERLTLRRFNKYKWLLVRCPIVRDNDKWAKWEKEAAEKRPTSAEEWAQRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7C1</accession>
    <name>A0A914H7C1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7C1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14684.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14684.t1"/>
        <property type="gene ID" value="Gr19_v10_g14684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037332832" description="Domain of unknown function DB domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="68"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14684.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19856" checksum="5F7C8D2FA5EA9FF1" modified="2023-02-22" version="1">MPKLLNILLIVALSSSITIDAQTADDAAQQAQQVSENIADEQPKCGTKETDFAPCLPREKADGLFKHCCQQYVPAGCHHLCQYETDELIARNLLLQAVKSKKCDLKHMGTILYCASQNQDNRKCCSQLNLSDAKLGVGERCLRFCDPGGEGGIAAIARSDVTCLFNWNVLMYCHHAGIKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7V0</accession>
    <name>A0A914H7V0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H7V0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1403.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1403.t1"/>
        <property type="gene ID" value="Gr19_v10_g1403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="843"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1403.t1"/>
        </source>
    </evidence>
    <sequence length="1161" mass="129237" checksum="DEBDF4133D917618" modified="2023-02-22" version="1">MAYPSDTVIILSYAFLSFELLTDIIVLGIACLNLVVLGLTTLLHSNLKCILIIQSVAVGLYVLDRSAMLLIKFISYDNVFAPANMTLQTFMTFDTIFKRMLGHALIIERFVATVRINSYENCQKFYFNLAWFSITFIIAFLNMITNGQSWAVTQFNLITSISSTVLSFVEFLMITIIGLYNRRKYNSQIEAAFANNYHIGQRYQVSENVKTAKQLLPAFFCIFLSNVTTNLMYIIISFNLVEEAYQKSLAFAFFIWLDAIISGAIELTVITHHPLLKKRFLLTRRLFFTVYDLFLFLAIASSDPPNSSESDKCSILSDATASDGIYLECHSQNALLQFTDEQQQRHRNVWSLRLDCGGGTDRGEGDQAQQDKVFEKLVNADQFRTLKKLSLLHCGPSSARFSRLAQLDELDFGTSEIARLDWQSIGSIHLRSLTIGRLSAVGGCKECRNGWLMERPKVFWPHPIFPRLPQNIITIASALPPNCTFSHCGKESARFEQKLVQSRLGSPLQLRCHFQTPNPMISSDSSVPNASSNNQNAIFVWPFSNYAEERRWEERPSIGGGSVELIVDALDSHHLGVVVCRCWHCNTPRFDVAEVRFWTPLSVSLNVDTYDEGGGGGVEETGTSTLLIVHGYPLERLRLGVRLLPNNLTEWHEFPAVGSTQQTFLNGSLLVRPESDHSQFFLRYFSLGIHDCSGCSHSQVGGTYALTVCRWPQNSEAGDEAAIPIAQCADTVSVQLTPTKHPTSNGASKMQTSAGFKWSSFVLLPSSVLLILVIIALSVSVVAVGSRARKTAITRNKKMMRCRKMSAYTQRTDETSIQLYAMSRYLSSTNDRHGLHVIDSECLLLKEPLGKGAFGEVYAALWIQKTDGIAANCEEDKGGESGTNLLPVAAAAAAEQPNGIGQGTARKVAMKFLTNLRINDEMQKEASLLAQLDHPNVLRMFGTSNWQGQIALVLELMNHGNLQRYLQSRAPRNSDYSPPPLISSELINISIQIAKGLCYLVQRKIVHRDLAARNCLVSGDCDLSCSSAASRPPICVKISDFGSSAALLPLRWTSPECLINGIYTHQSDIWSFGVLLFELFSYGDMPFGNLSNGEVSCALKNGKVPGVPEQCSPELDELMRRCWDQNAGDRISAEDALQRLKNIREQDRAQDALIFAQPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA55</accession>
    <name>A0A914HA55_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HA55"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15461.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15461.t1"/>
        <property type="gene ID" value="Gr19_v10_g15461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15461.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10033" checksum="F0B98CC79F7DF905" modified="2023-02-22" version="1">MKRKCLKTTGDKVLLLSEKRSKMEAGEATFSSDISALLLFWRRRSSSFCRVPMAVGKRTRPCALVEQLAIAKHCLRRACAVAFGSQLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAJ1</accession>
    <name>A0A914HAJ1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-lysine N-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914HAJ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15578.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15578.t1"/>
        <property type="gene ID" value="Gr19_v10_g15578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041523">
        <property type="entry name" value="ROQ_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048575">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052249">
        <property type="entry name" value="Roquin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139">
        <property type="entry name" value="RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139:SF54">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18386">
        <property type="entry name" value="ROQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21206">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="882"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15578.t1"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115425" checksum="13438F0B1FB9B033" modified="2023-02-22" version="1">MEIDNTDDDLSLSQSTLLALNEFLQDQERSRKDGHLFENWQLSQFWYTDETCRQLVDECICALNGSGRVACLSCPSVVAHFMDTKEVKTNAIELSLFEYDTRFADKFGNAFVYYDYRRPLDVPDKFHHQFDVLLVDPPFLSDECLIKVAQTIRLLSKRSESGGSKLLVNTGVVMEQLLKRILDVKKTDFRPSHKNNLANEFYKQHPNQQTRTTTSPMAFGIAQHQLWTEILCCPKCGNVFSVEHLPVTLSCGHLLCSCCVDEHAFCPFDKTAAKWDGSSKMYVNVPVLSIVLGDEELAKQHMERSMKSLCSSDSPQYETVKRLECSLQTFASFLYKVDSEKGATVSSSRLGRAIQHKLFSLLCANLWQEESRAQMLKLLRSMSGQIVSELIPCIEGTVNLSSALWSAVRARGCQFLGPAPQEDVLRHIHRALMRGELLARKTLVLHIVDKLSCQHSSISKTCVGHVVQLLYRASCFNVIKQEGQSSLMQLKEEFRSFETLRFEHDSQIVQIAIDAGLRTHMQTVCDRINSKSLQTDALRKLIDKKQAERNLFGIQTKLEHFDALFTAENLNASENEVWTQIEELLVHMSEVLKVYSDFFENRNAEKEQRRSQKAYVLSRGGRCQDVALLNNGGDHAGVGRTPLRSLARMPPIPIDFGCRPNMVHPPLLYAPQPPQTTTLTTTYIEQPPFPMGSPPGFYTSMSVSSTPFLPPSTNNNNVGSPPLSSPYIQQKQFQMDALETMPGQFFSILPTHPFGPTFVQPLNTVTASANTILTSTTVPSTNNSPLDGRTTLFATAQSTSPFSTSPPGYQFSPASTHMVAPPGAFQIPVQPQSLIVYGSPPFGSPPLLLSPFTNWTTPLDSTGGLLNGANYCNINTVNNNNNTTSLAERSPQKRNEQSFESEEDHQTPNVKRERKYRHSSRTTVDEDDSECHVSFTVATSVLHGHDEEHSFGSVGWMELPPLPVGQLNMHIPLSPSNVTYTVACDSAKTNLCTIIRPSTSSASTSNTLMTMCPPVSALPIVQDLGTDAAVLKDIPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB21</accession>
    <name>A0A914HB21_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1571.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1571.t1"/>
        <property type="gene ID" value="Gr19_v10_g1571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1571.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9540" checksum="C2AD3631B0D8AC4B" modified="2023-02-22" version="1">MLKKNAVLASTSKMRSEEQIDKNKFNADFAKKALKEKSKSSIALKVGPFAAIKESEKRKKKNGSLDLAEEGEEERPRERASTTGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCB5</accession>
    <name>A0A914HCB5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15746.t4">
        <property type="protein sequence ID" value="Gr19_v10_g15746.t4"/>
        <property type="gene ID" value="Gr19_v10_g15746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056314">
        <property type="entry name" value="AP3B1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029390">
        <property type="entry name" value="AP3B_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14796">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24080">
        <property type="entry name" value="AP3B1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01355">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="AP-3 complex subunit beta C-terminal" evidence="3">
        <location>
            <begin position="57"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15746.t4"/>
        </source>
    </evidence>
    <sequence length="375" mass="42094" checksum="47A76405C336D79F" modified="2023-02-22" version="1">MQHEDESDDGQGVEEEPIPSNSKPREEEETIAEEQTAEAQPLVVKTTTKKDGQQKAVHSEDLLLLDIDFGPPSTHINFVVSKWRRATAQYVPDRFELQLVESLSSGGLCIAGRFCRSPCLYSTSMVTVQLQLSYQSRHIRCCDVRLSPATNCFLPTSGPILVEALKEGERRTLTLGIDFGDSTQTSEWTVKWGEGGEKTTKFDVQAPYEEQVEGIECDAEQFVECRAKLTGMNQIRCALSRKTDQFIGRALLKVCNCKQVLGLKLCFAAQTVSRKELVLISLVGRGKEDRFDDDTDDCSVQVNCDNITFASDVTVRLPAKTFIHSLTFCDSNLYNIPFCFVCFSSTKHRQIDQLADTLIGIVLPFLLLQVWFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF55</accession>
    <name>A0A914HF55_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF55"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16576.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16576.t2"/>
        <property type="gene ID" value="Gr19_v10_g16576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037355477" evidence="1">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16576.t2"/>
        </source>
    </evidence>
    <sequence length="337" mass="38748" checksum="28B647089A61DBED" modified="2023-02-22" version="1">MAFALLPLFVVTFIQFGHSRMPVPNEFELNPPKIELLLRRTALMALLRAKANAMLETVPLVDKVLFRQCVIESNALSPVKLAKCLAKLIQLRDQLQRQNEWEENAAPEGKEGRNDFFQSSLITKRKLARIRHFFALWRRWKGRRLAELKMKNRRITLGLGGATDKRKPDEVEAVRHKAVRRDTVRRNTATLLLNDDNLRNLQELERYTRVFDKARRSIAQINAHNTELISRFDPSARVRSAMPDGPPALLDLQHQIERFFNSLGIDKISLLSPRFFSLFPSSQRRRPNLLSPDLFSFHNNSASPLSIPSLLSSVHLSERESAAWLELLMNITGSARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFX1</accession>
    <name>A0A914HFX1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Vesicle protein sorting 29</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the Csubcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to snx17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves Cand WASH complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFX1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17141.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17141.t1"/>
        <property type="gene ID" value="Gr19_v10_g17141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17141.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19687" checksum="4E0699374C8E6213" modified="2023-02-22" version="1">MLVLVIGDFHIPFRAYALPPKFRKLLVPNKMQHVLCTGNCTRETFDYLKSLTCDVHCVRGDFDDNTAYPDVKVIPFIPWGNLKAMELAARQMNVDVLISGHTHECKVYEKEGVFYVNPGSATGAFSIVKDDVIPSFIVMDVQQDLIVSYIYRLLNDEVKVERVQFRKNRADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGK6</accession>
    <name>A0A914HGK6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGK6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16424.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16424.t1"/>
        <property type="gene ID" value="Gr19_v10_g16424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="180"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="417"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16424.t1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56921" checksum="922DC0C7B963207D" modified="2023-02-22" version="1">MYSFLVAGRQLYGDYLVELFTQLLYPTEANASDGTATDKQQQSLKQPEFIGLLFSLLTTLLGMALWWLLLSVFVLLILLAALHRPLPLRIADRKKIAFFEFLMRLFNEYFGSLVEFVAGHSVRNKLSRALSYVMFPALPRWLFRWLFGAHWCDVSNERIAGVKCRLYLPKGEKRRHNGAIVFIHGGGWCIGKPRFYDGALLYLSWKLGLPVVSIDYSLSPEAKFPTALFECERVIAELNSQRFVTYGIDPTKIALMGDSAGANLCAVICQRALKAGNPSTIRCQVLVYPVIHMLNFRSSSYRYFYQSYPGTGLLNPNLLIRWCLMYLGIDPSPHNIRKIAQNRHLSKQLLGNEQMMALIDERNLPPGLPGGKGGMCRGQEQKDGKEFARNGHNKGNKVGDEPRPDIELSERMAPFLTNPDICPLLGTNLEGLCSAMICTAGVDILRDEGILYAQRLRQFGVSVEWKHYEHAYHGILNMCKSRQRLRILADISDYLQRKLIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHL9</accession>
    <name>A0A914HHL9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HHL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17439.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17439.t1"/>
        <property type="gene ID" value="Gr19_v10_g17439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06610">
        <property type="entry name" value="STKc_OSR1_SPAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000114">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000068">
        <property type="entry name" value="STE20/SPS1-related proline-alanine-rich protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF16">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17439.t1"/>
        </source>
    </evidence>
    <sequence length="484" mass="53429" checksum="7770F05969700AEE" modified="2023-02-22" version="1">MAVVDVVTGGHWPGTKDEYELKDAIGVGATATVFKAFCKSRNEMCAIKCINLEKCQTSVDELSHEIQAMSLCSHPNVVHYYTSFVVGEELWVVMRLLSCGSMLDILKRKIKAIGKDQAAYGVLDEVVIATVLKEVLRGLEYFHNSGQIHRDIKAGNILLANDGTVQIADFGVSGLLAANGGDLSRQKVRHTFVGTPCWMAPEVMEQVAGYDFKADIWSFGILCIELATGTAPYHRYPPMKVLMLTLQNDPPSLETNAERKDQYKAYGKSFRTVIKDCLQKDPTKRPAASELLKNSFFKKAKDKSWLIHSLIENLGSAPIIPTIPKKVASGKLKKDKDGVWEFEYDTSGDENSSDPDNATIMQSGSVERPSVSRASNEGEQMPPLQTLNLVLRVRNQQRELNDIKFDYSPDADTVDGIAHELVTAELIDGHDLVVVAANLAKLIDLDQKRAERRTITFALNSGVAPNEIPDERSLTGFAQLSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHS6</accession>
    <name>A0A914HHS6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHS6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17490.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17490.t1"/>
        <property type="gene ID" value="Gr19_v10_g17490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="7">
        <location>
            <begin position="329"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17490.t1"/>
        </source>
    </evidence>
    <sequence length="589" mass="68653" checksum="651B78788CDE2E57" modified="2023-02-22" version="1">MSDNKSDEEQQQQMERIFICADIWYEVFNFLSPFDLGLKLALINDRFDALVDVHFKSREWSLDWMIIRRANDGNGAQIVNARSREGLRIPQGPLPDNVIGFKHIEISYLDQNVIKFLEEICRPNFGTTVFIESFYDHSWEIIRQKIWPLVNDNICGFLRLSPSVFDRLRQFSPTILRDCAKLRSIHSLQLFPEFPASDDTDATSAQALTEWLITPRGDDLPKMLYCEFFSARMDELKGSFVNASERANFIIKFLENDDFEPFELKNNWTGERLTFRQIDEDKWLLVRCPIEREEDKWANWEKEAIEWKRRRHWNFIAITFQDNDIGDGTATLLLRILAQYSDLLVLFAHCAMELTMDVVQMLKAFNSRTCQLILGAGARQLVGLKMISVKHLTLALRSLQFIAQFIPTLRQSFSNELPTDRHTLLRHFDQTQRDFEDHAREIRSKMLGLMDRELIGALEEWRLEGKTPTASFQQIVMQIGKFYSSYSAIMPPELTTEILLQIHMNFKLYLRQHLNSRGISPHDSIAYGMAGQDFAYYMENVRALPDCKSFPVDTIGDFRFTPCADMPNCRLDAHGAFNRHSCKRGPTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI59</accession>
    <name>A0A914HI59_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pellino</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI59"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17588.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17588.t2"/>
        <property type="gene ID" value="Gr19_v10_g17588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF2">
        <property type="entry name" value="PROTEIN PELLINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="1">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17588.t2"/>
        </source>
    </evidence>
    <sequence length="136" mass="15127" checksum="F3B21B0DB49389C0" modified="2023-02-22" version="1">MANKREESSVVEPELSSLLYSVGSEEAFDIVPNDCCYGQLILLGYNGTSETYSCRSNNQDSGRKHFVKMFFNRRKESNGIRKGSVMTISKAANEAPAVKDSTRHTVSYSYGKSGTVLVEYLPDSSRDMFQEGCSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIJ8</accession>
    <name>A0A914HIJ8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914HIJ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17697.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17697.t1"/>
        <property type="gene ID" value="Gr19_v10_g17697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="127"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="251"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17697.t1"/>
        </source>
    </evidence>
    <sequence length="426" mass="46977" checksum="E28C9EEA077F01EA" modified="2023-02-22" version="1">MDVDVVPDAVGQTFLFTSESVSEGHPDKMCDIISDSVLDAHLVQDPNAKVACETVTKSGMILLCGEITSKANVDYQQLVRGVVREIGFDDELNKGFDYKTCKVLVELEQQAPEIAAGVWMNKADEKDIGAGDQGLMFGYATDETEEAMPLSLLIAHKLLAKLHELRRDGTLDWSFPDSKSQVTVEYKFNKGACVPIRVHTVVISAQHKQFDGDLTEVRSDLREKVIKEVIPAHLLDERTIYYLNPCGSFHIGGPKSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSGAYGARWVAKSLVKAGVCRRCLVQVSYAIAISKPLSITVISYGTSPLTEQELLQIVNDNFDLRPGVIIKELGLKRAIYSRTAANGHFGHTDFPWEKPKPLQIRPELEAKLIAYRKSEHIPNGCLKEMHIIRPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJP7</accession>
    <name>A0A914HJP7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2109.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2109.t2"/>
        <property type="gene ID" value="Gr19_v10_g2109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037089086" evidence="2">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2109.t2"/>
        </source>
    </evidence>
    <sequence length="346" mass="35798" checksum="EAE9863BDE666482" modified="2023-02-22" version="1">MRTILFLAVLCLITASILETGATPETSPKKTNASSKTGPASPGKPGPPSPGKHGPPSHDKTGPPSPGKHGPPSHDKTGPPSPGKHGPPSHDKTGPPSPGKHGPPSHDKTGPPSPGKPGPPSHGKTGPPSDGKTGPPSPGKHGPAAGTVKLVNSPSMKLSTAQAKKSPSKSDPKSPSTKSPIKSEDTKSPKKKSSPIRANRLAHMRIDEHHSSAQATPPNSPDNKSEQLDNEPEEELENPGLVMKVDKSESAPKSSNSPLLVDNDDDDDDDDDDSMEDHGIKLAEAPKSLLDDDNDDDGDKDGMDGDVDSASNESGSKTATMRDNNEVSKEDPFGADDALKEPVVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMP7</accession>
    <name>A0A914HMP7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2207.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2207.t1"/>
        <property type="gene ID" value="Gr19_v10_g2207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2207.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43470" checksum="02A6CDE8E8FBE837" modified="2023-02-22" version="1">MIGDIPAQKSVIKSPTAEFILNKNVGKLSTFPTRRNSFNSLRTYGHNSLLYNFQTYNEDLKYPKNRKIIKISSQMSSNSKDFFSNGKKIRFNYGNQLKIMLENCVAYENKRKFLSLEILGTIGQQSPGQGYNMLALKAAVEKEEEILMGPKIGGVKHILKIATAMWAAIKQVNAAAVGRIPNGVAEEQMRFIGLVLAHLVFRDDPIVDPETGDYVFFAQMEPAIDPIDPHVWRQMQKELDTQLRAQLACQEILVEEKDVGNVLAEKELHEILKNKISRGISTRAEWAKWLELEEKFRLISLNHHKVPHFNLIFRTFIAFGDEAPKLILLVRVLLEGTIDEHQFDKYLETGSGDELLKFIHHHPSEMMSKQLKSLAKQFGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMR2</accession>
    <name>A0A914HMR2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMR2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2018.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2018.t1"/>
        <property type="gene ID" value="Gr19_v10_g2018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2018.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22633" checksum="0BAC5BCE1D8CAA18" modified="2023-02-22" version="1">MAMFALLLLPVDDLKMEMNKSENELAKVRKEFAVTEAEALGEMKLAKEALRECREMDKEWEKDNDWMKQQTERAEKAVRESQQIEETMREMLEKMEAKDPDQQGCDRQNTKTVPAFNRIVGSTKAFSHSVDHIPQRNRKERIAMFQIHGFNTPAYPSISSTPHIFPILIKNRSFIFSNVPWTNPRVYEIHDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPN3</accession>
    <name>A0A914HPN3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPN3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2737.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2737.t1"/>
        <property type="gene ID" value="Gr19_v10_g2737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2737.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20427" checksum="2F7C2A139BFE39A3" modified="2023-02-22" version="1">MLRQLIRQCHFPFIPSAAFFAFGSLFMLIWWLSMGLSSINNSPIVNQTFTIKPSNLISLTNIPIDANVSPQSKNEHLAAAFGSLWPQLSQLNCNSLINNGTKFKQFGGGKRRRIVQKDPPHVNLDTNCSAIRARWHFVEKAGTSREAHFPLAFARTVFRVWFNIYAIYSSQPIKRKWNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQC1</accession>
    <name>A0A914HQC1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQC1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3474.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3474.t1"/>
        <property type="gene ID" value="Gr19_v10_g3474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3474.t1"/>
        </source>
    </evidence>
    <sequence length="362" mass="42227" checksum="6714C02ADB2D4256" modified="2023-02-22" version="1">MPSKQQRLRKMGKEQRLTDQSVSPGSQIPNSPRLDYSADGNEEASLGTTRALQISTPASATGKKRGRPPKAGNKGLVAGLDCVSLADTPNSTVPESATSSPCLKKEKSFEFDKKVITEVVSSTPVSTRGKRGRPFKKKGGPGRGKTVDSMSESSIMDESFVGNETMQVEEPLDDVDANLKLEKPSKFWYLYEFIVTFHYLYFPIFNQCFANFVECHLMFSLVPEVYGEINGARKPDMKQYREELKDMKQYKEELKDMKQYQEELKDMKQYKEELKDMKQYKEELKDMKQYKEELKEMKQYQEELKDMKQYKEELKDMKQYKEELKALKQYKKEFDIKQYKEEFKLYLFERPISDTDHDQMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQI9</accession>
    <name>A0A914HQI9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914HQI9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2779.t4">
        <property type="protein sequence ID" value="Gr19_v10_g2779.t4"/>
        <property type="gene ID" value="Gr19_v10_g2779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="IMD" evidence="16">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="547"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2779.t4"/>
        </source>
    </evidence>
    <sequence length="985" mass="107686" checksum="088C09D7D54B2507" modified="2023-02-22" version="1">MLTSGMVRELKASTSAWETFGCRAAKLASQLQQVATAFGSFVDGLQTISDSANSVNGVSRDIGAALTRFCLRQRSVELAIRKWGETLQKQCADDLGRRSGEWRQTVSDLERRHQRNCKRFKASGGGKHNNNKNRQQIEAESRNFYIELLHAQRAQCTEFVVGTLLPIINAQMVLLDEGAHIQPILDSLETSVNENDTAKLVQALLEDIDACSGANGHGMAPKRGENDDQLAWDQRIGIGMALGRAKSASQARLFGVGPERAMEEDDHSLNYGSTAMLTANRNSMPPPSVNSHQQQLFSSCPSSAAATISSSSSSAFVVGSPASKGNNCGGAVGSGDGAAEDIWQQNISRNVPSSHQRMPLPQPFVHHQMAAERADIVSPTLAADTLPQNQCQKPPMPAVPATTTAATNIQYDDDICWTFIGHPILCTVNKNHSKCIYCCHSGIARQFDAQHADSTDSGSHCSSALIAETLQQIDRLGLELDNYCDGLDELNNDGGSERVGDGSHRLAAPFRPVVGNNRQQTAAMAFAETASSTAVRFRSSTAAHAQRFVVPPPPPPPPPLPPQRRNSAISSATPSAPSIAELRSIGASAPFGPSLHQLAALHPKGAVPPSPSPMPPHSPKNGGFVQFCCHSVTGSATRPPALYRPAEADFGHGLLPVHAVHAAHRHFAFVFCRAILFAYFMVKFRFFPQIRPFFWPVLLLYLCWFAWDFGAPSRGSHFCPFLHNLPVWRHLANYFPISVVKTAELPTDRNYLFSAHPHGIVGSSSFIFFATNGANFASIFPDLKMHSVTLDLNFWFPLRREMIMGSRMIPSNSKAIEWVLSRPGGGFAVGIVPGGAAEAMESFPGTNRLITARRKGFIKLAIKHGASIVPVFHFGETDVFHQSKSGEGSTLRKIQNSMKRLTRISFPLAYGQSFLAALLSEERARKLPRWLRVGFFPYRRKIVTVVGEPMEIEKNANCDEQTVDKIHSAYCESLRKLFDEHKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRB5</accession>
    <name>A0A914HRB5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3926.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3926.t1"/>
        <property type="gene ID" value="Gr19_v10_g3926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3926.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12840" checksum="D4DDFD01DC52AB23" modified="2023-02-22" version="1">MAYTTLLNHSKKLQKTGQHEIARCCPNSVCRFGIVCNLSGWQGSEKALEAATLLADTNAPPSCDSNIADDASSRPSTNPGQSSGQKSKIELVLLILRFWALLYMQRGDAKALPNYQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRC9</accession>
    <name>A0A914HRC9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3219.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3219.t1"/>
        <property type="gene ID" value="Gr19_v10_g3219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3219.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19105" checksum="70C299AC1B01555E" modified="2023-02-22" version="1">MEEFWIVICVSFFATNLLDKAETVKLELKTFEEIFGEGWWDNGEAEDLKTPAPTNFGQNVHHQIDRQNTQIGQIEPDSTDQNPPHTEWKSELGQSKPKPIYANSKQKELMKRYYEIKDQNPQIRDVDIAKSLKIGIRTLYNWKQQMHPNSVDENSVEVNAGSNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS19</accession>
    <name>A0A914HS19_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS19"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4135.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4135.t1"/>
        <property type="gene ID" value="Gr19_v10_g4135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037871655" evidence="2">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4135.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26024" checksum="E42679B9AF219770" modified="2023-02-22" version="1">MKYNKISPFLFTLCLILAVYLVSAMEDVSSPSKSATSSPIAIKNDKRNSPSRKAGQGAKVKKTIKEIVKAVTEGQFLESLKFTNSFFELFAEKLLSDGKFASLVQGACTEGQTEMERLMNAHERAINLYKLILDEMLAVWTQKSENDNETKKKIEKINEDKVVKHWVILTNWTALKERLLHKKEVTVGSPPIGGKVPRKHQTLCTFNNDPNRRFSPPKSPRANPLAVYGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSD8</accession>
    <name>A0A914HSD8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSD8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g379.t1">
        <property type="protein sequence ID" value="Gr19_v10_g379.t1"/>
        <property type="gene ID" value="Gr19_v10_g379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF38">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g379.t1"/>
        </source>
    </evidence>
    <sequence length="635" mass="71864" checksum="6409CCD1DA81B489" modified="2023-02-22" version="1">MPQKRQLVSVDPTNLDMLFFRTAVAALFRAKAELILVSLPPTERIVHRQCEIDSDGRLNLLAKCLVSLLNMRDFAANSNSDLKSLNAAELPLIETLSEQLFKTKLIVEKEKHQKENGIKKNPKKLLDLLSLSQKLLTNSKKVKAWTRGNRVMLNINNKRGAQSSNEFHVDEKVLKTYPNVQKLIRIERFYRSVEKCNKYIRRKDEQHSKFFQSAGMPFRLYTKSAERSPLLELVESQLKGTVRFDKLSVLSPKVLSILPERVNTLKRPIQDNMTVPNSLNLLLSPTFLSFHEHGFFSLPYLLKLGLSNGNETLGWLDLLLQLSGASKTLDKLMKSLEPTFEEVQRQILPTILRLEELEERFRRLEIAQSRRQRDEMDSRGFTFLTGEQSRIILGSENFDEFGEDGVDDIEAVLEEDIRMIARTSDAEVSNISNLIDQRPNAPNGRREKRFLRTEPYGTVRLLNPYLFANQLHDGAVLRRVALSPKAFAAELLSPDFARLDLLSPGAFVPSILSPRAMIAHILSPTAFSARILSPQSHLAEVLNPRVFDAKILSPRALVALVLSPRMLITEILTPKALELRVLSPSVLAFNLLSPNLLGAQFASPQFFVTTVLSPNILSPQFLNEGFGNVQKESNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTA9</accession>
    <name>A0A914HTA9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTA9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4268.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4268.t1"/>
        <property type="gene ID" value="Gr19_v10_g4268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="5">
        <location>
            <begin position="226"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="632"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="760"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="793"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="826"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="879"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="912"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4268.t1"/>
        </source>
    </evidence>
    <sequence length="1017" mass="111850" checksum="41B96976EF0FBD59" modified="2023-02-22" version="1">MSIPTATNGGDITRARLYSREARLKVCKLLIAKGANANQKSNKGATPWLVACGKGHLDIVKHFVNERQDIEVSDIHGCTGLMYASRTGKLDVVRFLLSIGASVDQTIKHDFTALLWAASRGHLDVCRELMANGANTNLKTRDGGTPGLIACAFGHLDIVKLFVEETGWDIEVSDNESRTGLMYASGKGKLDVVRYLLSKGASIDRIDTSGCGGKTALDKAIAEGHVEVGKRLFLLKNPWTNLRWKGRFSEKDVTSWTPEMCAKLDYNPKDAQQFDDGIFWIDYPSICAFFDVFYVNWSPALFPFRHALHSSWDAGKGPVKDLYTVGENPQYFLELNNRHGTASVWILLRPFDPKPLLEGTRINSPHYLCQLIIREPVYLMTQFIKMLTLATFFPIVEGEYSFSYELMKSAVVMEELNKFALSAVECDRLGQTDEAIFIIRFLLKINMSIPTESTNGGDITADQEGLGPTLTNSDVSEELRLLRARIAQLERQQTMNSPTSSDGFYLVSKDEIEPNNNDKESMAYPEKEQATFELENKMEEYHNKQQQTIDTALPEKQNAFLACERFGGNLNFDGICYNCAVGHGIDVSGHGIDVSESARDSAELLYASIIGKENDVRFLLSKGARVDRTTDEGFSPLFLAAGEGHLEVCKLLIANGADTNQKTNNGGTPWFEACERGHLDIVKFFVENGQNIEFAGRIGHTTPLMAYIKANEKKLPYGSTIKKIKQKQNGMGQGCCKGTRGTCGTSDTAVGQRIGVSDRRGCTALMCASRAGEMNIVIFLLSKGARVDRITNEGFSPLFLAAREGHLEVCKLLIANGADTNQKTDDGETPWLEACGNSHLDIVKLFVENGQDIEATGSIGCTAILEERKELASLFKQQYGCTGLICASRAGKLDVVRFLLSKGARVDRTGHNGFSSLLWAAHRGDLEVCKALVAKGADANQKSHRGESPWLAACEQGHLNIVELFVDNGQVNNVVRFLLAKGARTAQTDANGKTALDIAEANHDEDGNNVDPLTVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTM8</accession>
    <name>A0A914HTM8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTM8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3658.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3658.t1"/>
        <property type="gene ID" value="Gr19_v10_g3658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3658.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15539" checksum="291824420C4CA5A5" modified="2023-02-22" version="1">MGNWISTVLFPLRAFMHGFFVGRKSRALLSPQDVLFPPISYVLAMNGRPDLLDQLNFYLERKNVNAIVHAERVLLDLGLANIREAFINGVEEKMICRRCDRQIKFIDSLCYCAASAEKCHCTGCCNNRKIKALTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUU9</accession>
    <name>A0A914HUU9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional repressor p66 coiled-coil MBD2-interaction domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HUU9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4383.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4383.t2"/>
        <property type="gene ID" value="Gr19_v10_g4383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040386">
        <property type="entry name" value="P66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455:SF7">
        <property type="entry name" value="SIMJANG, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR P66-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="891"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4383.t2"/>
        </source>
    </evidence>
    <sequence length="1166" mass="125667" checksum="6E154188509CB66D" modified="2023-02-22" version="1">MLADMGDNTNGGSGVHSVGASRRNHPNGNGASSLAQAEAEANATMLLCNVCSDGHDDNERGEEGEDEKLSNTTNSDCADCKSAEKSAKKTTDHKTPPQHDENTEQPDNNTNDVVDNDNNDFSVQLSANCPSLRRSTRVSALNAKKQQSEQRSAAEQQDRDSSSCTKSRQRTDELDMVQEHSTGAGDGVVPTTTGMDVVVDGDASTLSQSPQHRVTSLKRKLKRKLDDGQELDQYDCKFGIRLDTDGDVVMMSDESDISSLNEADVAVLRERYENVRRQEVPNDVLTQRELQIRELESVLRLEEAKLFMLKKLQQSQQKAVQKMQQQQQQQQQQECVRRLAPGVVQNSSGQAYKPKVAVVNPSPHQSGNANKANGTSQHGKKGLAKADVAALQNGAGIGASLGSMTNSGAGIQLAALPPQHQQVIQQLYTRLSQNPQQLAQMIKTLPHGTGQALTELLRQYAVAQASNMPTSGGQVQNSNAASAAKFSQHLQSSATSQAIAQAQIDAAHKQARELTQQKIVTARQQLRKELDVMFIPNGNQPDFSYLLGLDLTVQRVLKDKSMFRKVDFPPYQCEECETDFTPSWKAICGEQEDYHLYCERCIRQAQKRKVRQDYTALLKRAFQQVQDKEKEFERQVLAGKYNVEPVLPTPPSMAAPTQQQTTTTTTSTGSVHNQLKQTQQQHNVQATVSNQSSTSAALKNVSSTVAAAAALQPFNQHQQHHHQQQQQQQNASSTALNLSKSAGGGGITNTVTSVTSSAKSHHASSSQQTKSSSAKRISAGATPSSSSSSATVANPLAALAQNPQLQQQFAAMASFSSSPLFRQMLSNPMLAATMANNPMVFQHLYSALATQQQQRTQQQQQNAQNSAANASGAGAGNAMAAALIQAAAQQVHQQQNRSSTSSSTAAVSTTNSGGGAANLPSSTASSSSSSANSIAQQMAAMAAFVSNPMLALQSQLSQLGAGGGGGANNANAQLLSQLTSNPQLLRQFHQIKTERSNQTDGTTTTTTNGARRYTTTALLCLMMMLVVLLLLLFCALPTAQQKVSLLSWTSSHRLLPPSRIPCPKTFTTYSSSCHRSICDATCGSAEFETHTHTHSPNFLVTHRLLSLFVCFCFVGCHHSIPSPQHLNTFITTTMSMQLWHFCVGSLGGGMGTRRPVPPSLFPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV20</accession>
    <name>A0A914HV20_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HV20"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4250.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4250.t1"/>
        <property type="gene ID" value="Gr19_v10_g4250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000166">
        <property type="entry name" value="Protein CBR-DEG-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038169620" evidence="5">
        <location>
            <begin position="18"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="104"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="327"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4250.t1"/>
        </source>
    </evidence>
    <sequence length="623" mass="72806" checksum="7588016F8EC04C2C" modified="2023-02-22" version="1">MLLRVTLLLLLPVGTMSDDIRQLRFEKTGREIRLATEMHAWGYQHLQEEIASSSAIDDIRIRSNSLRTGRLPNSSGIWKRKSKMKNVSNLMPPEQRHVGMTAHARLIEDLVNRRYYESTVHPRRNYLQPTRVNVSMSLYQLLEVDERSQTITANVWMVQDWYDEFLDWNPEDYELLNRTIVPYENIWIPDTVLYNSAQMDRKNSEAVMNAIVETGHWRNDGQGAAVQLMFPAIYKLSCKMDVRFFPYDQQNCSFIISSWTHDMATIDYHFARPTVNMKNYVVDDEWDVISFEFSRQELQFKCCVRPWAMLYAHLVIRRKPLYYIVNLVIPTSIITVVAVIGFFTPSSSTSERDEKLYLGINTLLTMSLMLLMVTNQMPNTSNYVPLMGWYYMGIIFVIVFGTILATIVLFIHARKSHLQPLPHSLLKILVQPWFRTLVLEPPANLFELWTEYGLLKPEQKGEEVGDDGDGAVQRKEPCCHPLLRLCRLFAIARHPFEKALRHEREMAERTRKAAEEASKAVGRERRRRETIVEAADFLAQGVYGRRKTELHQLQRRMRQSRHSVLGSGANSRLVKRQKLMRRCALEWEFLANSLDRLFLFLFSLVTAFFFCLLAFFDKMFCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVY8</accession>
    <name>A0A914HVY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4506.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4506.t1"/>
        <property type="gene ID" value="Gr19_v10_g4506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4506.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9030" checksum="111EA278F5A7695D" modified="2023-02-22" version="1">MLTVKIEICFDRFNGSVGGGTLSADLIRMIRARFKWKWTATAAADVECSAGGDGRTEGEGAAMSGEKTGFMRGEVGYGKCAFVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWU1</accession>
    <name>A0A914HWU1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWU1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4748.t3">
        <property type="protein sequence ID" value="Gr19_v10_g4748.t3"/>
        <property type="gene ID" value="Gr19_v10_g4748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4748.t3"/>
        </source>
    </evidence>
    <sequence length="389" mass="44565" checksum="E6374085280EBBCB" modified="2023-02-22" version="1">MKKSQLLFNPQTFVVVAVISLINYTTPTLLLNIVHALLQLFLFVVTGGRRNILKVQRQHLADEKRSEMGDQQQQQQQQQQKASELYNKFSVLGEHRLSVNFPQQPNTNTYYSNPQYSVHTRDWGIHFLLETDLDANPVTAEVTFWQWYRSKQIHILQKSVKVFPQSGAHLQLQCNAGSNSAPSDGFFNVLIRLLEKKEQKIVENPCPPCDVDDEFVLKVGLEQFTVSKHYLMSVSPVFHKMFSVDMLERAQGEVNLEETNAEEFSAFLEAISPKLAHPNPSTVMGLLKLADRFQVDSLRNRCEVHLINCVEMSLIERLLCSEVYRLEKLKNYILKSLSGVGMREFYEENQAALNLLSKDLLIQLTVRICASFKIDRSALCNNCAKNLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXG6</accession>
    <name>A0A914HXG6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A914HXG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5560.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5560.t1"/>
        <property type="gene ID" value="Gr19_v10_g5560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000190">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="890"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1001"/>
            <end position="1025"/>
        </location>
    </feature>
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            <begin position="1045"/>
            <end position="1065"/>
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            <begin position="61"/>
            <end position="118"/>
        </location>
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        <location>
            <begin position="825"/>
            <end position="1074"/>
        </location>
    </feature>
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        <location>
            <begin position="1111"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1151"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1201"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="415"/>
        </location>
    </feature>
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        <location>
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    <sequence length="1231" mass="138720" checksum="150ED1111F23F31A" modified="2023-02-22" version="1">MDWLRAHLPSYSAIRDSTFASLTSSMSSQQSSVGGGGHAQQKRGSANGAVAPRTIVVNGAQQPQKYCNNQISTCKYNVMTFLPRFLIEQFRRYSNVFFLIIAVLQQIPEVSPTGRYTTADIKRRRMDIEVNNYKVEVLDTAPALVAGGAKIRVAKWKQLRVGEIIRVKEGQFFPADIVLLSSSEAMGMAYIETAQLDGETNLKIRQAIPNTAQLTDMAQLRALNAQIECEPPNRRVNEFAGTLRVANDEKAPLSIGQFLLRGAKLKNCRWVFGVVVYTGHDSRLLMNSTSAPLKTSRIDVMTNQRIVILFLMLVLITVVSVIGAEVFNKWLLDGHWYTGAIGHWSFWWNMLTFFILYNNLIPISLQVTLEIVRFFQASYINQDILMYDEASDVSATARTSNLNEELGQVQFLMTDKTGTLTRNIMTFKRCQIGPIGYGDDDREDFDDPQLRHDMTSGRNGNGAQIYEFLTMLATCHSVVPEREESGHIRFQASSPDEAALVRAAQNQGFTFHTRRPNEIVVETGGSDRTFELLNALVFTSDRKRMSVILREKSADGAAEIKLFCKGADNVIFERLSKELNDRQMLARCNGALNDYAQKGYRTLCFASAVLDPAVYAQWSRDFKTASTAIEEREKQLEAVAEQIECNLRLIAVTAIEDKLQENVPLTIRTLLAAGIRIWMLTGDKLETAVQIAQSSSLCHKDTELMVLAERSFDVVLAKLHEYTLKSHQFMLSNTAFALVIDGASLHHAVIGEARRVFAELIVNCHSVICCRMTPMQKAEVVEIVKSLGNNKTVMAVGDGANDVAMIQAANVGVGISGVEGLQAASVSDYSIAQFQFLRRLLLVHGTWNFERSVKVILYSFYKNICLYIIELWFAFFSAFSGVTIFERWTIAMFNVTFTALPPIILGLFDRPLSQRMILRHPQLYQSFQQMAFSNDRFFMWVGVSLWHSLLLFFLNFGFYSSGVVWAGGNTGGWLMFGNSLYTFVVATVCLKALLECDSWTWIIVGCCLGSILLWFVYLIIYSRIWPLFPLGSDMSGMFMIMVSSPSFWMALIFIPVTTLLFDFVVKSFCTSLRPSPRERFCLREKRRTLVGCNITDLDGGVRREEVRQPYDDGFEECSGSNGKHFDNHYHNQQQQQTLRQRSHEKQPNRPPQKSQHPNCSGNAALLQCPSNNSSSSAEDDVQQQQQKGGSSNNLFSHPHSTDQQPHFHLSNTNNNGQRNKTFHCHHLQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I072</accession>
    <name>A0A914I072_GLORO</name>
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        <submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
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            <taxon>Heteroderidae</taxon>
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            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I072"/>
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        <property type="gene ID" value="Gr19_v10_g5394"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Proteomes" id="UP000887572"/>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5394.t1"/>
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    <sequence length="66" mass="7562" checksum="AA53083BE677F6D0" modified="2023-02-22" version="1">MHIKLLTEFWSKELSETARINGTEASRQLGKREYLTSKVVRVGISESTSRSRKSDQLKAPIKLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0I3</accession>
    <name>A0A914I0I3_GLORO</name>
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        <submittedName>
            <fullName evidence="2">Transposase</fullName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="Gr19_v10_g5741"/>
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            <dbReference type="WBParaSite" id="Gr19_v10_g5741.t1"/>
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    </evidence>
    <sequence length="116" mass="13529" checksum="72A1035266B5A1AB" modified="2023-02-22" version="1">MKAELKRDGFKSSYKNELDKTVAKELGLSFTTIYKWKSELGQTTPNKYPHSEQTELMKCYYEIKDQNPKMSDADIAKMFRIGSRTLVNWKRQFKRQQFHPNSVDENSVEENAAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0S9</accession>
    <name>A0A914I0S9_GLORO</name>
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        <submittedName>
            <fullName evidence="19">VWFA domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0S9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5817.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5817.t1"/>
        <property type="gene ID" value="Gr19_v10_g5817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054180" evidence="16">
        <location>
            <begin position="21"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1249"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="271"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1168"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1198"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5817.t1"/>
        </source>
    </evidence>
    <sequence length="1274" mass="143247" checksum="CBE7A9D680EEF432" modified="2023-02-22" version="1">MNCSPFLIVLLVPSLPLLLAADGKSAGTKADQSVIKKADQLSRALLSIFKDGTKVDEIEKAYSNVADAEIFDPKTELDMVKTEMEQYLKSRTAVAWNAKLSLEQRHLISTSREALENGTFSMESLNNPNSPNFVRYLNAKRMSDAAMIYRDGQFLAAVEANATIEVRLRPNPNFHGLATSSDASAVHVPTPIYNRDAQLLERIQWSDIDQQYRRNREQLKDLNFQKFCSESGFLRYFPSASWLWEDRYSELDLYDCRNTEWYVNAATTPRNLLILLDTSGSMLGQRFEIARQTIETILGTLSDNDFFNIIHFSKQAILLEECDGRELVQATLRNKKLLLSRLYNISSEGKADYELALHKAFVALMNLPDESVFLRSKEEAAREATRREAAKVPETETPADGIRRIVLEDNVLTVPKRFLEAINKFTGSQQRMGCQDMIILITDGAPGFYREIFDLYNREKRVRFFSFVVGEEAKDFEQVRWMACANRGFMAHISSMADVQEKVQQYVRVLSRTVSRQKAAFSEATPLWSEATRERMSDDFIVSVSFPSLHFALLDGSGYALIHPQLRPLEATGELKAGFNSLDWQDVEAQGTHSNWLHSFKCASGKIEPQSQRTLFAVEKMRHVYPQENHYQVVCIDGTPYSLVLAMPSGDTKRLKRVRSSEEVQLNWLKGNDWRLHPNWRYCHLNDSDAAMGPERAFREYAKQMKSGGNMPEFCRHRRGLVARALLDLQASNGFSELWRQEWERNKKNGVHLAFFVAPSGVVRFHNQSLGDRLLYAHPHLSATESGGSNQAYKHFLLELNPNAAEADFFRRAVRQPPDQITFDLNRETRLWQGHGRKTAYGHAENESLLALAYKTVRVDEAVAGVAGIEFLYDTLVAQMRHIGCLSTDNDRIRCYLLDEHGYVFFSSSHSTRYSDFIHSNIVLPQIALQTAQNMTLSGRKRKGQRAYIANRVAQQQGAFAGGANPPSGHQLELGRFFGHLNRVAEWTMELLLRKGLYKRLYFTDAQAVCDSQSAPTDWSSSQTWAPTAVAASAHRLAAFLQSSLSSTFCLLLQFGAFLSALLLPTELAHGLQLNTFASLLKVNDGRFPCRQHAAFYLAQPQVSAGGTDGALLESDSYERPCRQNAAQCAVRVFASWVPRTNLLLVTVHQGARSHCFHSDPAHCPMSQPSEIPFGFSSSQPPPDGVAEEPSPAAAANGQGTARQCATSRPQPRQQPKQCLRDEFPENEPTNEGCVGASATGARETERSLFWMAFLSSLLALGITSSTIVGFWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I157</accession>
    <name>A0A914I157_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I157"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6533.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6533.t1"/>
        <property type="gene ID" value="Gr19_v10_g6533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36493:SF8">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36493">
        <property type="entry name" value="NEUROBLAST DIFFERENTIATION-ASSOCIATED PROTEIN AHNAK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038123960" evidence="1">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6533.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24722" checksum="2E4CF4B19FAF11A7" modified="2023-02-22" version="1">MIPAIGVSLLLFLARLISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQKMPISVQDQCQNDKRHCRKSRRSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I193</accession>
    <name>A0A914I193_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I193"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5944.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5944.t1"/>
        <property type="gene ID" value="Gr19_v10_g5944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5944.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21951" checksum="E6D0390D78658CB5" modified="2023-02-22" version="1">MTIWMGMVAKELCHNGIKRHGICIFGLKDLVPNLNGSHPFMFANKMMLHQDAEAVQCWHEAMFNRTYLFPTLKRLNKKFYTELPQVRYNVAKRQSNGTFNADKFACRYAFIERVKMYQELRGDYKKTASRFKSSDDIVECVIVDEQYQHWLQQQLNTTTGVSTSTQQQQLNNTKDTKCEVSTSTKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I374</accession>
    <name>A0A914I374_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914I374"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6458.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6458.t1"/>
        <property type="gene ID" value="Gr19_v10_g6458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036768636" description="beta-fructofuranosidase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="139"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6458.t1"/>
        </source>
    </evidence>
    <sequence length="789" mass="89820" checksum="44A1854363664E91" modified="2023-02-22" version="1">MLLLAFLFATSLFLIHGTGTEGVSRVNVLLLDDSTLHVWVRPVKKGEVAKVYLCPPTEAGTIEQSGQLIAECKQYSSDLWHDFIEINGKTAGAYTLTWTETTHASLVYVFKPKTVLEEGIRILFIGEEAKLPNLEGSYHFRAPFGWNSDTCGFNRSKDGLFHLFYQHFPHAVQWYSMHWGHAVSKDLINWVHLPIFMIPPNLLHLDFENGHFTGSSINLPNGELGVFWSQRISDVPRGTVAEYPWRELQQYVTTKNLIRPDWTTHKTIIERFPTVDPPLGNNFHDPVVFLGPGGYHYMTVGAERRNGSAGLVLLYKNKNKNADQLDRDWEYQGILYEDKRNEELRMCECPMLIALGDPLNANTEWVLSYVSDKGSHPAPIRGTDAEGRERMNPLFVGRFDGRKFEHRFVQQMDFVGGSFTYQGFYDKQSGRSYLIGWICDISWLNDNTGDPNFDGRGGVTSFTLPKEFVLSENGQYLMVRPLPELASLREKKQPHVITKGQEMHLEKGQAELVFEFSWDNGREETFELHLTPTHTNGKKLEFRIDNNGLQLKRTWVTSNKRLVVYNAMPTKIHIFIDLDTVEYFADEGRWSGSIRLPEASQEKRIGTVELKSAPLMLKEASMWYLNYKAHKSATALAAASASSFNSAIVSLRCARVNRRPLRLVASAIMAALSSIWAMSVPYSSALPWPMLRLKKSRSATIPPMRTAMRALSSLTEYSSFSAPLVTPSYSNSTDGITVSAPSMLTFFRKQYLFLSRRHHHHLEEVQLFFYIHPQASTRAKLPAVRVRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I397</accession>
    <name>A0A914I397_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-galactosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914I397"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g710.t1">
        <property type="protein sequence ID" value="Gr19_v10_g710.t1"/>
        <property type="gene ID" value="Gr19_v10_g710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019377">
        <property type="term" value="P:glycolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000070">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036881314" description="Alpha-galactosidase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="15">
        <location>
            <begin position="345"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g710.t1"/>
        </source>
    </evidence>
    <sequence length="416" mass="47867" checksum="6BE4784C49B991D4" modified="2023-02-22" version="1">MMKKLIIWASLFLFISFVCSLDNGLARTPPMGWMSWAKFFCETDCARHPFSCINERLYMEMADRLAEDGFREAGYEYVHIDDCWMESSRDGNGKLVANRTRFASGMRALSEYMHDRGLKLGIYEDIGTSTCAGYPGSLNHLKIDAQTFADWNVDYLKLDGCYLNASQFSDEYPKMSRALNETGRPIVYSCSWPDYLDHNYEEQINYTAIGYWCNLWRNFDDVERSWGSVLSIINFYTKHQDLFRKAQAPGRWNDPDMLIVGNTELTVDQAKVQMSIWAIWSAPLIMSNDLRTILPEHREILLNKRVIAVDQDPLGIMGRMVFKSFSVYVYTKEMTPVDNVNKRFSYAIAVLNYGFLPIRFSTDLKSIGLTNPKGYYVQCLWSGKMFGHFTPRDIYNVTLAPTSVALLKATLPIGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I411</accession>
    <name>A0A914I411_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I411"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6399.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6399.t1"/>
        <property type="gene ID" value="Gr19_v10_g6399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21525:SF9">
        <property type="entry name" value="CHANNEL_COLICIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21525">
        <property type="entry name" value="MOTILE SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037226331" evidence="1">
        <location>
            <begin position="26"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6399.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31157" checksum="6B6D488D10F63CF5" modified="2023-02-22" version="1">MYGRHRCLFTCIYIVLLLLLHHVLAAQRHYKIKRQDGRLMAYKGGESEIRDYARYATAGTAAGAASGAAVGVAVGTFVPVIGNVVGGIWGMIYGGGAGFVGGSIAYLGVQSACDNRCAKGTYACVTAENVSMPCCRTHFTQQCYSDWGEIVTKYKRLTPPVFPIFDPTWEEKLAGPETQETANLPKAKTFSCQRGRQTLYESSNGPDKCPYESNQCYFVYCYDLSEAKTNDFAEWGCVYKNHTDICRHLSKIKFKCTCVLADLDAEMANERYAFNNYKPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I493</accession>
    <name>A0A914I493_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I493"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7165.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7165.t2"/>
        <property type="gene ID" value="Gr19_v10_g7165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7165.t2"/>
        </source>
    </evidence>
    <sequence length="155" mass="16759" checksum="CB24A4182EC25387" modified="2023-02-22" version="1">MKSMDGMGFDSSSSASSWLLAAQEEASLPSSPRPSDFGGVAGSPPPPCPLRACRDCLCLPNHPFRGSSASFPPILNGKKAFFALSIQYREDVRGKGCTGAAAGGKGRGNEEEEEEEEEEEENEAWGKGGGRKMEMGRRNRSRMIGKNEDEEKEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4B5</accession>
    <name>A0A914I4B5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4B5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7385.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7385.t2"/>
        <property type="gene ID" value="Gr19_v10_g7385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017025">
        <property type="entry name" value="Cancer-assoc_antigen_RCAS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208:SF2">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS CANCER ASSOCIATED SURFACE ANTIGEN RCAS1 ESTROGEN RECEPTOR-BINDING FRAGMENT- ASSOCIATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7385.t2"/>
        </source>
    </evidence>
    <sequence length="391" mass="44899" checksum="DD61C4E7F6B049B4" modified="2023-02-22" version="1">MCDFHEPAPVNIITENLRPMSLGLPMLLLRRLLSVLLALFSTVYKLISCRFFRRHENRIGELPFVVPSAEKAQNATAAADWDIWKAEPTAVADQIAEYRRQKQEEAAKMRAKRPNQRHSPRASLEPSSPHEADLFTELQPNVKAPKKLLLRPKQSKQRNLFAVQPTESGFPVEVGRLDELGDLDFEQPTKSSSWLDDEESLELCQIDAVEREQRRSERERRHKARLAEHAAVLHQKQLQQQQQQHNHLAAATPTAGSNECHQGVIPHTPRCRNYYPSNSSDWLNSFLRLWLDCFCYALWLMFLNRSACIINHSRRLNRFICTMPIMMQQVAVSNSGRHILIGIIVKKLFNNGGKATQFETTFITTSSACTFVQRVAHFPHMTVAEPWPFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4B6</accession>
    <name>A0A914I4B6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4B6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7184.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7184.t1"/>
        <property type="gene ID" value="Gr19_v10_g7184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7184.t1"/>
        </source>
    </evidence>
    <sequence length="371" mass="43104" checksum="F0F4FD1B6DA45F12" modified="2023-02-22" version="1">MPDVSLLKMLGRRLFTTLCARHRLRVPERVPCFCYSVVGTNNDQLLRQQIDSNIQTQDDQHELRQMLRTIVDTHLANGQIFFVPWANDRAILTLLSPFKQLTAQGVSLEFLIDACTKSADLFVTLTKNGREAIKKFTIFVECLEMTYEDAMRFYAKRADGLDSVSADSIQQRLSVFLGRGILAGAQLKMLVKRWPDILFMGNPQTMDMFWEEISGFFAMSDMKKLMLNSPQICLLDVEEIVEIYEYIYFHMGIESDELTESTNWLNLRLEQIMARHEFLLKTGKYTFPDPKKPQLKKENPTASRIFDVSDLEFATKVGCVSHEEWIVFQDLRKLEELLSEKERPYERVLPAMRKQFERKVKEAVEKEAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I534</accession>
    <name>A0A914I534_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g697.t1">
        <property type="protein sequence ID" value="Gr19_v10_g697.t1"/>
        <property type="gene ID" value="Gr19_v10_g697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8206" evidence="2">
        <location>
            <begin position="1244"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1634"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1641"/>
            <end position="1650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g697.t1"/>
        </source>
    </evidence>
    <sequence length="1672" mass="188403" checksum="A364183352C4CE3C" modified="2023-02-22" version="1">MMTSSPNTTDGDLTADKVHLWPSFARPIAELADELAELAQRQQTNSPSLTESGFDLVSTVGGQNDEDDGIEQFGNEDVAVTVQQDDQLSEHQQQPPTTNGRPTGKKKCLAILQVQRVDKSTTFCPSLRYEFFVTEAEPLSSDSEDCNPTVGDMTRAILSKHLAMSMEQVAAQFDLQVQIRERAYMPDTVFFDIDQQQCRAERVEHLGEYKVLLHPKLDDDNNSVRSVSARTIVPETVEGGGRRCDDEEMPMGAQQNANRDDRLDDVVPLSGQQNATKDWEPINRFCVSGGKAPLGNLYSVLSDNFVTSNELGFMRKIFNMNSYTEKSMPTLGKDIIEIDHLDRLEERTKMLGTEQKLSVVSRLALLDNACPLGRFLLAASQKEGQKNNSFGIIQILPEKIISLKLNEPYVRNSVLQQNPQKDATHFVGSTCFGSLVAAIVTVDQQISDVKNLVLKHIRGYPMSSSDKDSLNALNNSVRVSVFVDSSIGSGGTDLDLLYGLDVFVESSKKSVCFNYGFGHPISFSLIPISAIVDDKSLQHTVLMPASVIEDDSLLVERIQYCAQFVEHFERRLRKAGQSLNKYAFSLTFHHYDTLAQMFQHCEKEKAAIDQMLKNCVINLRRGQGTKEAERSTDALELAVDQFGSNGRSLLGHCDDLLQPKMELLRKLDSKGVQYIGRGNRRLTDLLLTNGGSRTLHFVLLYSESRTTPSAVAVGGSSSQHDGERFYRQCLGQLYQMAGRGKSCAFVDLDALLSDDEATAYGGLPQGILELDGFPNIGSRLVKMRGHKLLTADCVTEEAQKLQICIARIENPQRTEVGAVPQKKTEPCSLPCPLCEGYGGKCQNNDFLWGCDDCGRTLTYVKEENAPMTHFYCGCGATPVEEFSFRCSDVDAHGNEFRHFATKTQLTNELERLKSKGILTILLLGETGVGKSTLINAIVNYLKHPTFEEAIQADEIESVIPARFCTEEYDEDGNLVQKEVVIGKKSKDECLEPGKSQTKWPNAYITPSKVGHKIRLIDAPGILDTGGIKEDNLNLHKTLSFISTLPELHAICILLRPNSTRTGPAFKYCINGLLTYLHKNAAKNIFFMFTNARGSNYKMGKTRELLQGILKPIQDAHKVSIPLHRDRIYCLDNEAFEHLCLIKKANVRYSEENMADFSKSWTRAEQELQRMLKNVSALKPHRTWETVSLNKAHRTIVDLTYPLASISQSIQDNLIRIKEQQESINKGEQEMTTAPTFETVQFVPLQHPRTVCTSARCTEVKKTAAKEIKLYRRHCHPHCYLENIIAENMPNESLKNCWALGGNDKCRVAECGCDWSVHMHFRFEQVVVTHQLDDAKRKLFADKRQTLSTLEAYRLQMLHEREKIYSKAALFCSFLKTWALKPYNDSMEAYILLSIQDGERFVAESDGEADQKLQMEKLEGLRESLRLYKEQKELIDTANANVSTGLKAIKAEDVTEFFEELCKLPIFGKSIKQMYETQQKTREDNQREYSEEMAGIGFMPKPSRNGMPGNRVEQYLNELEQQSLINSYAKKQREMELLQHQQQRIEGQKRPYYEFDDFSSPNHSSTSKAWHCKGKSSVKIFDKSRAAKSSREFNSNAAQIASGSAGGFRQQPQLPDFDSFCRNLPFVGSVYSRVRPYPAQPPQLQQQEFEPCSSSDFDKSRYNNNNNNKRERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I556</accession>
    <name>A0A914I556_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="19">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18 19">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A914I556"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7616.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7616.t1"/>
        <property type="gene ID" value="Gr19_v10_g7616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="4 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18 19" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 18" id="KW-0521">NADP</keyword>
    <keyword evidence="10 18 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="518"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7616.t1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60831" checksum="F2B279554CE779A6" modified="2023-02-22" version="1">MPVPSEHFRIAIVGAGPSGLTAARQGLLYGCEVCIFEKEQSFGGVWRLAVSKNAQRRPVPLQSAMNCSKELCAFSELAIPDHLPTFLCPPDAVDYLELYVRTFTLAQHIRFGSEVKMIRRSDCWEKTGRWIVQWAENAQLNEGPVQVEELFDAVLLCTGTRLRPWRPPEYRMERKFKGTVIHSEQFTHSADFCGKTVCVVGLGNSGVALATMLAHTAEKVFLCTRRGQWVLPLLRADDEPWDCAFNSQWHFWSRQWVPKCFRNFSWEMCAKFVSNCRQSGQGPPTHRLLSANLTFGAEQLGPLLASGRIRIRPNILSLSDSNLVEFVDGTIEQHVDTVIICTGYEFDFGLVENGKTLRVMYNDFHLYKHMYAPELAPHHTLAVIGHVQPRGGCIWPIAELQARLFFHVFTGHIQLPTPFWMKAELEKRRCAVSMNMLKTRRHTQTEDFVQFMHELGAMIGAHPLPLRRLLGTDPRLGLSLLVGPCCSAQFRLVGLHSQHNIARQTIVAHQPNLFAIRHWWLIVLLIGTLLWLLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5K2</accession>
    <name>A0A914I5K2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5K2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10993.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10993.t1"/>
        <property type="gene ID" value="Gr19_v10_g10993"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6826.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6826.t1"/>
        <property type="gene ID" value="Gr19_v10_g6826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000382">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000011">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="15">
        <location>
            <begin position="628"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="16">
        <location>
            <begin position="786"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10993.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6826.t1"/>
        </source>
    </evidence>
    <sequence length="901" mass="99716" checksum="8F5DA42685843C08" modified="2023-02-22" version="1">MRRDKKDDEAAAGNPYDHLDKATVVQETRAFNETPVNARKCRPILCKLLYLLQHGETIGKTEATDTFFAITKLWQAKDMTLRMLVYLAIKELCQMSSDVIIVTSSLTKDMTGREDVYRAPAIRALCRILTDTGMLQAIERYMKQAIVDKTASVSSAALVSSLHLMRKSPEVVRRWANEVQEAVSTDNHMVQFHALSLLAQIRANDRLAILKMVQKFSKSGLRSPLALCQLIRVAAKLVAAEEEEGGGTAEARTAFAFIESCLRNKHEMVVYEAASAIVRLPRISSGELASAVSVLQLFLSSPKPALRFAAVRTLNKISIDYPQAVISCNVDLEQLITDGNRSIATLAITTLLKTGAEASVERLMKQIGTFVSEISDEFKIVVIEAIRSLCHRYPRKHATLMNFLASMLRDEGGFDYKKAIVDTIISIVEDNPSAKDLGLSHLCEFIEDCEHAALATRVLHLLGREGPTTANPSRYIRFIYNRVILESTQVRAAAVTALAKFGAECVQLRPSVLILLKRCLLDTDDEVRDRATFYLVVLRTENQQLILLYILGTLKVSAVGLERALEQYTHAGQFEQPFDLKQVPLSSEPLTAVEQGKKKATMLDDASAVANKKQQDVKKKTTSSRQDAFAQQLASIPAFAACGPLFKSCTTVELTETITEYNVSCVKHIFNEDYVLLQFDCRNTLNDQMLMDVFVEIELQDEDEDAPWHVQSVQPLAQLPYGQPGTTYVLLKMPEDGRIAGTFGAKLQFKVRDVDPITGEPEGNDLYDDVYALESVEVGLADFLLASAPKGSFTTAWEALAEAGGGHETEESYALSNVHTLEDAVSKLLKCTALYPCEHSDRVPEGKSSHQLLLSGIFRGGIDVLCRVRVVLDQADQTVSMNMIVRSTDETISQMIGNIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5N9</accession>
    <name>A0A914I5N9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein mesh</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7131.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7131.t1"/>
        <property type="gene ID" value="Gr19_v10_g7131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056075">
        <property type="entry name" value="DUF7658"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057017">
        <property type="entry name" value="F54D1_6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057018">
        <property type="entry name" value="F54D1_6-like_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057019">
        <property type="entry name" value="F54D1_6-like_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF60">
        <property type="entry name" value="PROTEIN CBG06057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24678">
        <property type="entry name" value="DUF7658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24469">
        <property type="entry name" value="F54D1_6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24462">
        <property type="entry name" value="Ig_F54D1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24464">
        <property type="entry name" value="Ig_F54D1_6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036674413" evidence="9">
        <location>
            <begin position="29"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1376"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="12">
        <location>
            <begin position="219"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="10">
        <location>
            <begin position="673"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="1297"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1412"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1449"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7131.t1"/>
        </source>
    </evidence>
    <sequence length="1513" mass="170559" checksum="75EACFF202A788CD" modified="2023-02-22" version="1">MAQWPLLRIPLPFFCIIILLCLAPFANAQFHQNPSHGTGGGDFGTGGIAPGAMPVGAGAVPPAAGGPNIGPAGASTMFTGGSDNLLYGVNLVPFGPEVGDHKVHPGFLTAGQTIDLYMYFPYYGGLYNYTTLSVNGYMAFATVLDQGPTINVGPEATDWPRQQDPAMIAPYLCKQQIPQNSNVALRAGIYYRLIMRQSIFGRGTSSNIGPDIGTMPESSFFGFRYKKCPAASDNYVRCDSNGDYFLDQMMRWLQEGVAGAAAFRADAALVVTWYNTASAISARADIDGGQLATYQVIWLTDLPGRLSYVILNYDKLGFDAADVRLNSRSGRCQALFNGGNHTGMVLVDPTQNYKNTPKVLAQRSGVPHMVRGRYMFRVDDVVRPGGCSNKTGGTYPIMIYPNIVNMLGEMTVDVNAICLDRTQTYILMIEQRQSASCTVLNPAMARCNIPKIYDWGTKTVYFQPQSQGANDERAFVGYIYFVPPTLDPMRLDIGNIYDWYKNPIPYQVMPITWFPRNFTNPDLNYMDQTWHISDDALYGVQLGLYVVGYKEAKDEQIKKFRPEHRVLCRLATYANRNTYEYRWNAQKERINLNQVEQWYLNDWERINELFTYRVGYLKLAPLRTNDQAFVAPQLLSGLVSAPISLHWLWTSGNPQYDTTTFSRQDADARQTFIAHKAKEMCHDWYDEDGAQWNFIRDVETNASCPCMEHQAKFDLGRFMPHPRCSQTFRDITCTSTIGAKNCYMSASNIYGSYSGQRFDYGHGQAYGEYGREFRDGRADGGQAGGAEGAGGPFGYGGYYGRERNQGNRFPTHYGQVCCYDEKGFLMQSTYQPVVKVIEETPYNPGYPNRAFEFGTPPYMGQFEVPGLSAFHHDYMPYFLCCKPSSGCQQYQPPAIGEAMGAGTFHTIDNDKFVFNEPGVYTLLYIPKTVNNPEVRIQVRLERYPNRRVDFSMLGRYLSQEQLVQPTNATVITGIALEATGTDRVHVMARGDTRRFRYRTSVIVGNILRYFDTMRLQRFRGVLIYVNNVERGQPEVYVVLEEAQIGIRIRESYAVDIDRMPMYQESMGLLDIALSVPPQYGVQPDGDKTREQEMRQRYNLPRVAGLMRPFPDTPTGTIYSTLTLNEVNSEAIRQQIITYYRVPGSGERFTDYQQQTLNQYQIPTDNMFTTSREEDKKFEAFPEASIKSEPIYKTAPIYETAQYRFVPRTGSVLMQMLQQCNDLANRETIGLQPYQGQMYWDWASQCPDNPGKILQECGDNVPCLYDFTLLNAEVLGNEVKDTWNAFFHDRWSAIQNYNSCGPINIEYPEYLIKTPALSSGYLQGDIARFECFQTHWIKGDAEYKCAQVVDYNYPQMWRFEWNKGSQPWCRSREMDNMLTWLTGILSTVGAILVLILCFLCCWCVKVRRRQEQHQSGGGRPFRRQFPRSFESESMPPKSDLSSSFTSPGGAKNGAGGGGVQPLLLPKTGAMRGAGPASPDTNELRERHPAGLTRAGGGGGTEEERRRLLGLNTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5Y5</accession>
    <name>A0A914I5Y5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paramyosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5Y5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7078.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7078.t1"/>
        <property type="gene ID" value="Gr19_v10_g7078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000035">
        <property type="entry name" value="Paramyosin, long form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-0518">Myosin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="13">
        <location>
            <begin position="97"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="913"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="96"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7078.t1"/>
        </source>
    </evidence>
    <sequence length="934" mass="107365" checksum="585B858003EC1688" modified="2023-02-22" version="1">MLGQISSQPASRSTTDRRERPEKQSAAAYNFPSHTSASPFAVCCFCSPTVLFVVMSNSLYRSPSTHGGALYKSPSMSAFAGGAPFGAMSVADLGSLTRLEDKIRLLQEDLESERELRNRIERERADLSVQLIALTDRLDDAEGTTDQQIEANRKRESELQKLRKLLEESQLEAEDALNVLRKKHNDACLDYNEQIEGLQKKNAKIDRERQRLQHEVIELTATIDQVQKEKHAAEKAAERFEAQAIDLANKVEDLNKHVNDLAQQRQRLQAENNDLLKEVHDQKVQLDNLQHVKYQLAQQLEEARRRLEDAERERSQMQAQLHQVQLELDAVRNALDEESAARAEAEHKLSLANTEISQWKNKFDAEVALHHEEVEDLRKKMMQKQAEYEEQIEIMLQKISQLEKAKSRLQSEVEVLIVDLEKAQNTIAILERAKEQLERTVAELKQRIDELTVELENTQRELRGALAELQKMKHLYEKAVEQKEMLARENKKLQDDLHEAKEALADANRKLHELDLENARLAGEIRELQTALKEADAARRDAENRAHRALAELQALRIEMERRLQEKEEEIENLRKNMQFEIDRLTCALADAEARMKAEISRLKKKYQAEIAELEMTVDNLNRANIEAQKTIKKQSEQLKVLQASLEDTQRQLQQTLDQYALAQRKVSALAAELEECKTALDNAIRARKQAELDLEEAHGRINDLQSINNNLTAIKNKLETELSTAQADLDEATKELHAADERANRALADAARAVEMLHEEQEHSMKIDALRKSLEEQVKQLQVQIQEAEAAALLGGKRVIAKLETRIRDLETALDEETRRHKETQNALRKKDRRIKEMQMQLDEEHKNFIMAQDTADRVLEKLNIQKRQLGEAEAVTMQNLQRVRRYQRELEDAEGRADQAESSLHLIRAKHRSSVVTNKSNSPKVYVLEDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6E5</accession>
    <name>A0A914I6E5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914I6E5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7188.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7188.t1"/>
        <property type="gene ID" value="Gr19_v10_g7188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="130"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="317"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7188.t1"/>
        </source>
    </evidence>
    <sequence length="677" mass="75797" checksum="6DB5D6CA9CBADCAA" modified="2023-02-22" version="1">MYASGPDIVSLGPKRPGPKRPWGPNSGPKRQGPNVGAQTAGPKRQGPNVLRAQFLFIQMPTEKNVNTPKKSKKKQELDQIEEVTKLYTKFDAEAISSGDPFSAFPLSLKTLKGLEDAKFTKPTDIQRLSLGHSILGKDVVGGAKTGSGKTLALIVPLLENLWRNRWTKTDGLGALIITPTRELAYQIYQMLNTVGKHHEFSVALLIGGTDVDFEKHRLAAVNIIICTPGRLLQHMDENEHFSCDQLQVLVIDEADRILDMGFRQQVRTPQRICALKRQTLLFSATQTRRTEDLVRVSLQDPVFVAAHEHCDKATPDQLVQSYFVCMEEDKLNMLWSFLKNNLKKKTLVFVTCCKQARFITQALSHLRPGLYFTGLWGDLKQNKRMEHFHRFDAATGGAAMVCTDVASRGLDFNGLDWVLQMDCPPTVDDYIHRVGRTARMNRKGEAMLMLTPSQEVFTTLLSERSVPINKVTVEPDKVFDVRNKINNLMIPNPSLKQFAQQSLVAYAKAVYFTNLKNVFDVRSIDFDALAKSYGLVVTPRIRFLRKMGMAPMGKSEANGKALPKLTMKTEQIVLGGMQGESNTENPFQIGGDTGCDDADDDVGDESFLKVSRRDVFSSISEVDVKEEVLSRISSKKPISKTLMAKKMIKRFGVVGKRKRFEDEVESDGEDDHKKIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7A4</accession>
    <name>A0A914I7A4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7A4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8163.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8163.t1"/>
        <property type="gene ID" value="Gr19_v10_g8163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032498">
        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF10">
        <property type="entry name" value="PI3K21B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="65"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="371"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8163.t1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56111" checksum="1A8B2039B1B4E695" modified="2023-02-22" version="1">MNLSSSSVLLENYCASHSRSSSLSSIDSIADTELPSSSRINEQPSNSGPQFDKSGCVADVTDKCWYWGSANKEIISAALENKQDGTFAVRDASTNGQFTLTLRVAGANKLIKILVENDKCGFTRDTFDFDSISSLVQFYRTCSLRDFNERLDMCLLYPLPSPDFVAREQNEANTSSKFSQMHRINLLKCRLEGFHAEYDRVSRRYDSLFSQMNISGDEFQRKKQTTAAYCEALKIFQRKIVELKRMEIEDGLSERDREALRANIELQQERMEEIGKAQELVNTALQNIGQTLSNLNGELEEHKPLLLKLYRKRDKCRDKILSLPKQQNTTHAQLDRQLEAVSLALDSEPVILSVFLIRAHFPMPEWDCERWLWHRGATKEQAVNILLKLLPNLKQKDGVFLIRPSSSHPGFYAMEISKDGNVHSCLIEYRDPRTSPEHCGVDFVRYYANTSLKEHNVMLDTTLKTPALELKRKQRESCSEENDETLPAQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7H3</accession>
    <name>A0A914I7H3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7H3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7340.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7340.t1"/>
        <property type="gene ID" value="Gr19_v10_g7340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="75"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="8">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7340.t1"/>
        </source>
    </evidence>
    <sequence length="609" mass="68630" checksum="0B9E82A85CD1E4F1" modified="2023-02-22" version="1">MAQTSSSSTSSSSAIITSSAMELVRELRDNPDTIPPYNGALLRKCAQQITELFNENLNTLMGLKDGTLHEEEQAITMVRMRQSAIEQIKRCCCTYVVERMQRLRHLRWTSGGQVPEAIKEALSAEERKWLTTYNQILFDFQTKFGQDDDDEGELDGQQQDIGGAGDGVNLLNHVEPPKTLMVQVRALRNFGTFETSEGIKVNLSKSSLHFLPRQDCENLTLFEEQMMPLTLSDDSHRRKHSHQLAQPHQDALLAPPEQPALCCALVRHENELLRRALRKEREKRMFATSAYQQLLQQFNQLVDLRTVMVGGPSSLSDSSIASSSSTPTTSRGRRSMMMVEKHKEMLMVAGSRRDAKVSTTPANSPQKQDRRQRREEIRAVPYVECRDGIEGDKENLGESGPTKGTHHRQKQQQQKKKIMGESQSVGVPPSASRSSTSSEAKLKNNNDDNILSGKTAERPNWYFVPLRRGESRENDAAVGRMFARCEQRCDAIREASRARAQIVAGRRAVAADLVTGRRALDAEAINVLLHTDSSRSVHAFPPAFMREQRYASRRCYDKSPVRLRQERERQRHFESAINRILAHSSATMTKMVATGRNTAGGQPRNSFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7R1</accession>
    <name>A0A914I7R1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7R1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g807.t1">
        <property type="protein sequence ID" value="Gr19_v10_g807.t1"/>
        <property type="gene ID" value="Gr19_v10_g807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037356900" evidence="2">
        <location>
            <begin position="21"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g807.t1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53398" checksum="078F09B40960D801" modified="2023-02-22" version="1">MHSFIIGLAFFAILPTELDAANDDEDKTPKNKGIRISTVPEDIVYNVNSQNFRDSVVRLTSAPQQQTSSSKRSASSPKASGGDGGGEAVKVPKSDGTIAAVPSQPFLPPNIPAWMVPLVQQQHQAVGQPQNDNATTLATTAAASAEGNNVVLKRKHSATAFGGNSKNMKMKGPLKAEPEETIDGPPAGDELQFAAEKALLRLDNSNLETQVFRILELSMWAIDFTFMGMHFVRTIQRNLELLLNNKLAKKNPIFSNIFEQIEAQIVNVFGHSPFKMEENEQKNLIGIMPVEQSKSAENNSKMHGALLFFYARLFRKLAGLLEAPHESPINPAKSPLSHREAQLIWITVAREIIAKQFPIDQHPEEFHLIAKFDEFDTVAEQLLLAEIKFRNPFWLTGQPLALPSLFSDFSLRQFANIMKSSTMDKMSTHFRFEGADQSVQTFGPIPITGGCAIDSQLQNAQKIMEFVKCVFDKRYCPIGGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I835</accession>
    <name>A0A914I835_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA2/NAM7 helicase helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I835"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g761.t2">
        <property type="protein sequence ID" value="Gr19_v10_g761.t2"/>
        <property type="gene ID" value="Gr19_v10_g761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13245">
        <property type="entry name" value="AAA_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g761.t2"/>
        </source>
    </evidence>
    <sequence length="747" mass="81089" checksum="B3311F6C36492696" modified="2023-02-22" version="1">MSKRRRMDTTEPALSDSTQEMMDTEDSPKKIPIFSLSPLHPVKSLGLQARELPNFSFKPITKPSPSPGNTGKSPTSSGSNVPGYEDLSPEIIVLDDPGPAPSRQHKNSEQTTPPPLATANVRLVSVLDFPDGDKTAESISSLSSSINWEEIVAQAWGLPMSDSPGPGPEEKSENPPHTNPTPSSLTEQVLKSTLISLLDPTGSSNFLSPQENTSAPPPASSQTSANAQPTSKTQGIQRRPSPTPSPPFENKGFSNGSAETLPALPASPGDNDFAIAIDPDIPPPRFNNAWKPDSLLICKKGNKVCAQGTVRQVQLTNPNHLSLQISVNLSETENQFLDLDTVLHLEIPSSQNQLHQRAGCFASLYPAQIARQQTPQGSIFSQILGSSNTHKISPTPELSFASFAKTLVPKPNLGQLDTLDLLFNPTPSIIATEAGPGTGKSQIIIMAIQRNLELGKSVLVTTHSNVALCRLASEILPKLAASSKALLLLSATAKENYMHFFAPLLPNLLVKTIADFSPQSATRGEAATIKKYKRNALQATRLADERTTAEIYLRDIGHEIPLLFATLSMLEDIPSTLRHTESVFIDEAGQAPTSQVIHILTRAPNLSKMLAVGDPKQLEVRTDELPENMRPYAFGSLLSHLLSLQNVPRTKLTISYRGHPILTQCLAASLYEGSITPGVTAEERSTTPSPSPSRSPPLAQQQQQQHQYQQHHHQQHQQQQSESMLGDERRIDGVRHVLTAQGWQRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I867</accession>
    <name>A0A914I867_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FAM50 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM50 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I867"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7536.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7536.t1"/>
        <property type="gene ID" value="Gr19_v10_g7536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="4">
        <location>
            <begin position="167"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7536.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36931" checksum="C186C2DDC5C1B3C1" modified="2023-02-22" version="1">MSQADAGRIIHIGKRRERAKEDIESQRQRLEEERRNLANSIKTKFTTNVDEQEEKFKARTVGLVTLDEVKERQNEFFYGDPSSKFPSEGRPKFERAVQKRVLSFGAFDDDDDEEDEGLIPITKKRLGMDPTVDTSFLPDRERDDQLQRERERIAREWQEMQEKEKNEEIMVAFCYWDGSSHRKDSKTKKGATIAQFLQKALDRFRKEFLELKLATVDNLMFVKEDLIIPHFYTFQDFIKTRQMGKTGPLWQFEAVGEIRVRQDAALDIGESHPVKVILRSWYEKNKHIYPASRWEPFVPGKVYKRTIDDLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I951</accession>
    <name>A0A914I951_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I951"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8420.t4">
        <property type="protein sequence ID" value="Gr19_v10_g8420.t4"/>
        <property type="gene ID" value="Gr19_v10_g8420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF250">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="842"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="709"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8420.t4"/>
        </source>
    </evidence>
    <sequence length="942" mass="107355" checksum="02B3D1B86C9894A0" modified="2023-02-22" version="1">MYLFPHLQITQNQPENLVEYSEFNQDRHRAENSYRLISNQTQKTSARHETRIAPPHQKNHYCHQNDTSHPFNLDQPPTVFQSPTFENGQNFNPKDYGGDQNFQFSQNKVVDRHGNDRYQFEERKGNNPVHSFEAEEHPNFRKALKQVVNRYGDDESNVYLAYLLALNQPNSHSHQTPRETSEYPTQPQNAPRREWTADGRDKKVNRYRAPNQNFRPANGRENSADPYGMPQRLNKVREGRGVRKRIEEDRQPNWNMESCSDGENLLPRKDQLSEPRHLHNPNSLTACPSGKDLTALHSADPVRLSTFSVIPCRELNKNVDSHLYPEVNKKFEGSPDKIPEPRIEEANVDWTLKGKEKEEQRQEIVVKFVTPTLGHAAAVSSPFRRSSTTGARGTSRGADRPVRTLADRIDPLRTSILRAIDSIPQAPTPKAGPGITDMVSWSVTHVKRVVVMIIINTEQYGNNNCSPSSLFRLSLLLPSPVAAAFLLSPLSASFSPPSRIRCLRQLCQFVHAFNGASTELVSTSNERDSLLFNFVSDEMRTLSSEEQTEQDDDNNLHTNALKARNVGAHFCLAPCFNTRWAFVRVSVNFDHFVVQKQLAWIRAELIRQQILRRIQHDFVEAVEFFERAAKRRSNARLPQLLRVFAAYFNVWVDNYDNNLSSETETPHTIFMIKLNALIDEFVDRNDPVKHARDAASLTVKQVKEKWHNMKKDSKRRFADEKREKRKTGGGRDESQPQDSVHSAIVDTFGERASFSGIPGARSTPLFADFSAEDDLEIQALTGLEEKPFKLMKTEFGQSPSPGPSRMRRSATSSVTDLQRNNEFRTKTDFFNYCSLPCVLGAIDCTHIRINSPGADDEQSYINRKGFYSINMQAIVDSKCQFMNVDVSWPGATHDSFVLRQSSTWEFFESGRGGNSILLGDSGYPLKTWLITPFLSPVTESQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Z9</accession>
    <name>A0A914I9Z9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9Z9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8057.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8057.t1"/>
        <property type="gene ID" value="Gr19_v10_g8057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8057.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="16922" checksum="B1CE5874C5E60779" modified="2023-02-22" version="1">MLNTDSNPGDLKFTTVEHFHKVLLYRGADLSMRNWQGQNSEQVAQFAGTLTVTGVIQGHDPHNIGTLSVVSSSVAGEYSTLRRNFVEQAGFEANVPRIMVIPRGRNDSESATFLLVVSGVGVRAASHEQMVKLIHQQSGKPITLGGFKSNWSVIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAV2</accession>
    <name>A0A914IAV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAV2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9118.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9118.t1"/>
        <property type="gene ID" value="Gr19_v10_g9118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036780124" evidence="1">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9118.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="11555" checksum="BF733B1937A03CF6" modified="2023-02-22" version="1">MSSSIAVIMLLVLANAFVVQADAAGINRFKRCSTCAPSYGYNGYGYNGGSAAAAASAAAANGGYGGYGGNAAAASSAAAANGGYGGYGGNAAAASSAAAANGGHGGYGGYGGYGGYGGCTTCGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBJ8</accession>
    <name>A0A914IBJ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein MON2 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8694.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8694.t1"/>
        <property type="gene ID" value="Gr19_v10_g8694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="228"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="352"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="989"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1244"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1620"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8694.t1"/>
        </source>
    </evidence>
    <sequence length="1766" mass="195266" checksum="2DD10E510C9803B0" modified="2023-02-22" version="1">MASSVAPGIVQQNDPKKLVEYLMGDLRLLSTEAKKKYNHIKEAAESGLVKVRNISSSASSSDNLLQSFRSLCTEIVHPFLLGCSSKNPRLVQISLQSIQKLLQFLAIDRNAVPGIVNELWALTEAECEELKVLQTITTFVSTELLVTDWALAKCIVLAFRLNFSKDSSVINAASAAVRHLFSTVFERAFQEDGMRGVGTEEMKILPQQKNLAANVQQSLAPPTLRPAAADAFLLLRDLCILIRRENPTWLIGIHKITPILALELLESVVKFYPSIFFRHSEFTELLKGYICPQVIKLIVGEREISLSSSTTNGGVVPPSNSTQNRSLPISAALLTQQQQHHQQQHGQIVTKARDFPIMIRSMRISLALLTNYHSILASQNELILSILLDLLCMPTNSWEAAVAIEVFRKIMAQPTLLKWLCARDEGGKFVELLFSRLTAFLRRCLEEAANDSPSVREDKVGGQQGFIFKGVFLPFDERQLSQKRSILLDWLDKHSAERIPEAYCLSVGFATLVDATGAVCSAVEGELLPDKGSAEGEEPMPEGKNSSTASPEFDVAKELFQVAHPFLTSGLSTLLEFSVDDSVTEHLLNCLTSMITLACKLGNAEAKHSLLKAFCRAALPCQYFSRFVGSNVPAVSMQNISVSNGTAAGTLSLNDLSLKESSVEPTQVVAMGTVCPSPHHPSQYFNTTVMMTAKNLQVARLLINCVHVNAHLLGGCWEMVLTTIQHFVWIIGLRPTSMGTFRAGGETKPASEGGGIMSTTSTSAASTVILTTAASSELPDLNQQLNMLFESTSSLDEVSIHHIIAALCKLSNESMMVAQVSSRETSFFSVAKLLQTALVNLSRLHVFWRPVTAHLIELCGHSNIATREWGAVSLTQLVKSAMKQTLAEFRVTETNKKTPNVEEITKREQLILNPLAAINEIEYLDVRVKQLDCLMRILQADSRPIEAPLWSSVLQIVTSVVVPDSRMNTITDPQLIDQAFRVLSLVIKEFLTVVPFECVEMLVETDALYGQQQIHLNVALASVGQLWDISDFVRRAQQSVRKEEEEKAWLCIYAALGRLCVDARPPVRKSACDTLLQTVAAHGQALGTQRWAEMLTDVLFPMLDRVRHLTQTASTHRSNTSSLGAPNIMIHHSRDTESKQWAETSVKTLGGVVKIFNAQRPMLLQLGGFSDFWSQLLTHIELAAKADNAEMSLAALKNMQDLLFGRQQQTESSHQSIGVRGKQSMANVRTYTDLSANPSLPEPLWLVCWSFWLRIAQAIVSPDCPATLDFVAPSPHTPSNESPFIPSTKKHFVPGLYHLTTLLEMFQQLFHRVRHQIPVEDVRSQRLSQIFQEIAAIPLANDPISISAHNTAEQLHPAQESLLNSIRLVIQEQIESNSPLRPALPDLLRLLLSFFQFAVQPPVNKFSAVFSAAPSQKVVPNTNVQCPPSQNTILFAEVSLKTALEFYTKTVAFDEVLQQTVLTDIVKRLAEPLSLKYRCPSQSTWQLSATTLIKACQVGFPIARENVNLFKGLWPAFAMAIENFLFSPSKSAHPLNADERKRHEFIDCLAIELIRTELLPYAATLPREFMQRIIDILNRGSINTMDSHDVLDAYQQRADLSRVCFDSLLSLSQTDATTAAATATTTRHHQQKSPTTSSSSGGGFLRNTSQTTAACSSLGATAIASLLQRCSKVLNDYAKDEQTAGHFRLPQERIFESISALQAITALIEGFSRNPNNPTLYSHLVTLHPSLVQLIPSSRGDHQVELALMTCLNSYQTLLLLNLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC45</accession>
    <name>A0A914IC45_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914IC45"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8833.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8833.t1"/>
        <property type="gene ID" value="Gr19_v10_g8833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8833.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27026" checksum="48E613E35798A477" modified="2023-02-22" version="1">MFGNYYSSDCSAVPAFPLGYHSRDQQTTGTTLVAMECKGGIAVATDSRTSMGSFIAVLLRAGVQSDSQAMADVIMYYAESNATMDEDDEIFVRNVANYARKMHYNYRGQIDSTLIVAGYDSIKKGQVYAITSGGYTTRQPYHVSGSGGTFIHEFIQSRWSEGIEGEVAREILKTAIFEAQRRDTYSGGLIHTALIDKNGTSRKTYRPDKEDFPTVLPVKAYPNLPEHILQPRIVEADQLERME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC48</accession>
    <name>A0A914IC48_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IC48"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8572.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8572.t1"/>
        <property type="gene ID" value="Gr19_v10_g8572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="207"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8572.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33768" checksum="DB051CAD3FF17A0C" modified="2023-02-22" version="1">MRQETSAVSVTDTTRTFTSVFPALAAGAIAGAIAKTTIAPLDRTKINFQVTPSRHYSFKAALRFVILTYRENGFVALFRGNSASLARIVPYAAVQFASHEEFCHLLKVDKNGPTPYRRFLAGALAGVTAVMFTYPLDTAKVRLSVSTKQEYRNLRAVFLKECRAHGFLTFYRGISPTLLGVIPYAGLAFFTYESCKLIYTQETGKPLNPLLRMAFGAFAGVVGQVSSYPLDIVRRRMQTGRMPARQGILVTLFDIWLYEGVIRGLYKGISMNWVKGPIAAGISFTTYDMFFERLKRWTGQMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICD6</accession>
    <name>A0A914ICD6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rubicon Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICD6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8596.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8596.t1"/>
        <property type="gene ID" value="Gr19_v10_g8596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052428">
        <property type="entry name" value="Autophagy_HostDef_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971">
        <property type="entry name" value="PHOX (PX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971:SF1">
        <property type="entry name" value="RUBICON, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="2">
        <location>
            <begin position="325"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8596.t1"/>
        </source>
    </evidence>
    <sequence length="552" mass="63678" checksum="60D21844E4E2BB2D" modified="2023-02-22" version="1">MCSEESSRSCSSRRANNLNLLTVTPAFPIPISPDILFSKLKESTHFTRGRCSSSVFVAEELSPENQSKLFAQDNLWDRLSLVSNDSVSSVSETEKDRQPIDQDKICVQLSDWLIHSMEERKWRQLTEGLDFRNEIDPVLHLGTVSPGTSDIQQSRLCSSPAMDYHREEGNSVFYTLSNEDTSQMATTSRVYDVAVDKSEPLSPPPLRLSPTLTRRRRSSDSHAMRKVPDYWDGPFVKRTSSIQQLIAVLAENLPPSPNALRRAEVLRTFDIPTFRIPSRKWRPPKKLFIFEHSKPMDFITQLALQKHRCAGCGLKLDHVYVKRTLYCHYYLKLFCQCCHQGSKARIPALILHDWNFKEYPPVFNVRLISPGLYRRAKNLRKFRKLRVKVAHMWPFVQMCKLAAELMTENGFLRTMFSSVPKRFLALESVDVFSLLDFERIANRNLIELVEPLALKGAAHIESCERCRQNAFLCQLCMDPNDLLFPFQVERCHRCDGCGSLTHWKCYRKTTTTNVLAETGVEEVRCEKCERIRRKKFRLQRKASPDRSTCGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICJ3</accession>
    <name>A0A914ICJ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICJ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8947.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8947.t1"/>
        <property type="gene ID" value="Gr19_v10_g8947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8947.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42953" checksum="2DCE77BBCB5706BC" modified="2023-02-22" version="1">MIAEAIERRRGQIGAAINKQKPFFLSFSSSNVVSVQMAEEEATATTDVVQHQQQQCNKPFCAVYAVENGHQQNKFATRRRGGGGGRSDNIHFQYDQNSYLSVSRTRHIFGSAGGDERSAHDGVGAEEEQQDNEMEAATASWHQTNHGDEQQRRLESLSPFFVRTGLTHCQHTDWDLLREVRVRELTEVRQRVTLMENTMRWWLSAAEQWREKWLKVKNERSRLREENLRLRKALSNAKVELHGLKSSDRSIVAQSPKGICCAETRCRPSPPATTTKTVVVVPPMCEKIVDKENNDCTSSSSNSSKRRRRRINSNFSLFVEWMYCLPSMGFLVPRQQPLKGLRHAQNHIFNALNFLIFFLYSISRDVSDVLWPLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICZ6</accession>
    <name>A0A914ICZ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SGF29 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICZ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8751.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8751.t1"/>
        <property type="gene ID" value="Gr19_v10_g8751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="164"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8751.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36304" checksum="DC3807523CC0E655" modified="2023-02-22" version="1">MRSRHLAKSKRGGFAVEDRQNQPTISSKNVQDQQTQHLLGRIFERLDRVQPKHQKVTESIRSIRSQGVRLMGSGPKMSQNSKTKMVVLYQTAQKQCEMEHSYLEQILSDMQNVRQLHLKQRMSDKLSRGSLMVLLAQHAAGLPLYIGSIDGHPPPLVGAIPQDSDEHITEGDFVAAFVEDIWILAEVKKQISTYKYEVKDVDDDDEDGEKLLTVPTGRLIPLPHFRADPRRHAHALFPVGAIVLALYPQTTCFYKGIVESPPTGPNDDYLVAFEDSTFPSGYSPTLPVPQLYVLTHCEVPQQQRKRRKSPLSSDLTDEAQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDK4</accession>
    <name>A0A914IDK4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDK4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8913.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8913.t1"/>
        <property type="gene ID" value="Gr19_v10_g8913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8913.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11011" checksum="FC1472794FBA4D77" modified="2023-02-22" version="1">MPRTQRLEAKCCFCPSDSPSFIKNRRIFGDGGEEDPCSILPSTHSNQQAVGVLYKSAEIGMKNRKVFTNNANSRQIKTETCTATNTTNNKYTEYGLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEJ2</accession>
    <name>A0A914IEJ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromo shadow domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IEJ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9486.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9486.t1"/>
        <property type="gene ID" value="Gr19_v10_g9486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00034">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo shadow" evidence="5">
        <location>
            <begin position="213"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9486.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30128" checksum="CD2E3DC55CC26727" modified="2023-02-22" version="1">MDKSGTFTKCTEEKEHSEALLQDKQLLIGLGEKLKLLQSMMGHDEQEKKALRAENVRLVSDNVELQGQLHEQQALSVRLQETVDDLQKQIIEIKVRCAALEQLAEFLIESLHCPELISEFEATHGYVETKSSKMAGRMNQKKGAKKRGATDKGANKGAKKRGATDKGADKGAKKRGATDKGADKGAKKQGATDATPTFVTKERYHIEEHGAVPDRIIGLMKHEESGNMMVLLTYTDNQEATEFVPTKLLRKKESTAKMILDFYEKRVEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFE9</accession>
    <name>A0A914IFE9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFE9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g974.t1">
        <property type="protein sequence ID" value="Gr19_v10_g974.t1"/>
        <property type="gene ID" value="Gr19_v10_g974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g974.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="36623" checksum="C7DE05B3A892DE27" modified="2023-02-22" version="1">MGKDYYKILGVAKGASEDDIKKAYRKMALKYHPDKNKDPGAENRFKAYDVLSDSKKKEVYDKFGEEGLKADGAAGPGGPGRGGGYHYTFQGDPMQMFAQAFGSNGMFSEFAFGGAGGGGPQVLFSGGGGEELFGGLGGGDFGGVFGIPRQHQQQRIKQDTAVTHELPITLEDLCKGCTKKMKITKKIVNPDGTSRTEDKVLTINVKPGWKSGTRITFPKEGDMYPNRVPADITFVIKDKPHSKFRRDGSDIRYKHVVPLRDALCGLSIKVPTLEGDTIPLIIKQVIKPGSTHRIHDRGIPNPKTSKRGDLVVEFDVRFPDSIAPAARDLIANALPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFQ5</accession>
    <name>A0A914IFQ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9823.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9823.t1"/>
        <property type="gene ID" value="Gr19_v10_g9823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9823.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18476" checksum="7DA0F21D2063956F" modified="2023-02-22" version="1">MLLIFANCPLTSFTAIGLWSSLRSVGFSTVYALGRDALSFVFADYPRARKMVLRRATQLQQRHERKMSKMSTGSAALFRRRSVCLSPFRDAEDSDQAATSLEERTADMRHAIWAITGDVERMESNFVINSMAMKQQMTSLEKEFIDQKPKLKARLESSKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFR7</accession>
    <name>A0A914IFR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Spectrin alpha chain</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g9832.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9832.t1"/>
        <property type="gene ID" value="Gr19_v10_g9832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045169">
        <property type="term" value="C:fusome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042062">
        <property type="term" value="P:long-term strengthening of neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11808">
        <property type="entry name" value="SH3_Alpha_Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000154">
        <property type="entry name" value="Alpha spectrin, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000258">
        <property type="entry name" value="Spectrin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000020">
        <property type="entry name" value="spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000006">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000013">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000017">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000035">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000078">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035825">
        <property type="entry name" value="Alpha_Spectrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="990"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="2284"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="2327"/>
            <end position="2362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="843"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1237"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1660"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1879"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2003"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2199"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9832.t1"/>
        </source>
    </evidence>
    <sequence length="2434" mass="283879" checksum="682D26EB9E0491D9" modified="2023-02-22" version="1">MADQHQQQQQDDLGPPPDPVMEVPPPKEIKVLESADDIQNRRTEVLDHYAQFQGFATIKRERLEEARQFQYFKRDADELEIWILEKLQTAAEESFRDPTNLQAKIQKHEAFVAEVQAHSNAITKLDKTGNDMIQHDHYEKDTIRKRLDRLHELWDRLFAMLEGKGIKLQQTLKLLQFVRKCDEMLYWIRDKIQFVSSDDLGADLEHVEVMQRKFDEFLKELKSHESRVLDINHEANTLIDEGHPEQQQIHGKRDEVNEAWHKLGTLTSTRGEALFGAQQIQRFYRDIDETLAWMGEKELALATDDYGRDLNNVQALQRKHEGTERDLAALESKMDKLGSETNRLCQLYPEKSGDIATKMDEAKGRWEALKLGAEQRKRGLDRSYNRHRFMADYRELGEWIKGIQALIQSSELAKDVAGAEALLEQHQEHKGEIEARADSFKQTAETGQRLLDEEDIDNADEIRQCLQHLAVEQSSLNNLWEERRILYEQCMDLQLFYRDTEQAESWMTKQEAFLQNDDLGDSLDAVESLLKKHEDFEKSLAAQEEKIHALDEFATKLIEGGHYAADDVAKRREKLLTRRRHLMERMAQRRERLKESYRLHSFDRDCDEMLGWIHEKSKTAKDQSYLDPTNIRGKLQKHGNFEQELRANRNRLDETKATGQELIQSGHYANEHIQSRLNEVEELWTELVDASGLKGAKLQEANQEQLFNRNIEDVELWLSELEGQLASEDFGKDLISVQNLQKKLGLVESDYNAHQERIDAIGHQTREFHDTGHFNAPLISKKFDVLQQRFEALREPLQRRKQKLAESLLGHQLFRDIDHELAWIREKEQIAASTNRGRDLVGVQNLIKKQNALHTEIANHEQQMEQVAQSAEQMVQRGHFLAPDIRDKKSQLRDNWRALKTKADKRKQDLQDSLQAHQYLADANEAESWMRDKEPLVGSTDYGKDEDSAESLLKKHRALMSDLEAFNTTIEELRKEAGQCKYQEQLGGQLGKECVVALYEYTEKSPREVSMKKGDVLTLLNASNKDWWKVEVSDRQGFVPAAYVKRIEPGSQHHHQALAGQPMNTINAKQSQSEDQYKRLLMLGEQRKRKLEEACKAYQLLREANDLAEWIRSRETVASQQEIGQDLEQVEVLQNKFNDFKNDLKANEVRLQEMNQIATRLSQMGQTETAVRIRQQIDDLNARWKALEQKAEERGQQLESAHEVQRFHKDVDETKDWIQEKNETLDSEDFGRDLRSVQALQRKHEGVERDLAALGDKIRALDEKANRLRQTHPEAAEQIYDLQRQLNEQWTTLTQKANRRKDKLLDSYDYQRFLSDYHDLMQWVDGMVQLVSSEELANDVTGAEALLERHQDYRTEIDARASTFHAYEQFGNQLIRSGHYAADDVRQRMEDVNEARRRLEEAWVERRKVLDQCLELQLFNRDCEQCDTWMSAREAFLSQEDPSGDNVESLIKKHEDFDKAIASQQEKLNNLDTLSRQLVQAGHYAAPQITAKRDQIFERWDQLKAALIEKRSKLGESQTLQQFSRDADEVENWMAEKFQVAQEETYRDPTNIQQKHQKQQAFEAELSANADRIATLISAGQNLITAAKCGGGETAVSARLRALNDQWEQLVKTTTEKSHRLKEANKQKTFMAAVKDLEFWLGEVETLLASEDYGRDLASIENLLKKHQLLEADITAHADRVEDMNRQADALLESEQFDQAQIDGRRRNINERYERVKDAANVRRDKLNKAITVHQFLRDIDEEESWIKEKKLLVSSDDYGRDLAGVQNLRRKHRRFDTELATHQPQVQVVRSKGMELMASSEIGVPEIVKRIKALDQSWTHMVELTEDRHKKLQESEEFQNFIGRVEEEEAWLNEKQQILSSPNVGENMAAVQGLLKKHDTFEVDLQMHQQRIDELQRQGEELINAGNHHAKNIGTRMEQLVKHLILVKELAVRRLQKLRDNNAYMQFMWKCDVVESWIGDKEPHVRSIDFGRDLSSVQLLLNKQDTFDNGLNNFEHEGIQRVTELKDQLLEAEHEQSAAIEQRHQAVIQRWQQLLMNSLERRKKLTEAQAHFKNIEDLYLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIRALREAHTEFQKSLVGAEDDFRQLQELDRQIKSYNVGPNPYTWFTIEALSETWQNLQKIIKERELELQKEHRRQEDNDKLRREFARQANDFHQWLGDTRGEMMEASGSLEQQLDTIRRKAQDIKAQRAKLKKVEDLGALLEEHLILDNRYTEHSTVGLAQAWDQLDQLAMRMQHNLEQQIQARNQSGVSEEALREFSMMFRHFDREKLGRLDHQQFKSCLRALGYDLPMVDEGQPEPEFQRILDLVDPNRDGYVTLQEFMAFMINKETENVRSSEEIEMAFRALSKEFRPYVIAEELFANLTPEQADYCINRMKPYVDAASGRTIAGALDFEQFVQSVFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IG44</accession>
    <name>A0A914IG44_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IG44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9562.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9562.t1"/>
        <property type="gene ID" value="Gr19_v10_g9562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9562.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13348" checksum="51D802CA69653AB2" modified="2023-02-22" version="1">MKTVKECSYDEKSPPPANKCPNISLQDPAPASDSYTMKSCMSELCSQECQKLAATIYRQYNFNFANKFNSDDYNNGNFQSSGYKFNRFFDYSNSFCREYYNNCFDNSNYHYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGM3</accession>
    <name>A0A914IGM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5667 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9700.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9700.t1"/>
        <property type="gene ID" value="Gr19_v10_g9700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037915651" evidence="1">
        <location>
            <begin position="22"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9700.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30254" checksum="0E1CFFD2C4EB3C74" modified="2023-02-22" version="1">MLLPAVFLLAPTIFIFNCAYAQNKSEPLKIVPNSAGYTFNKLVDELKEMTNSLWLAKGCQIIQKLQGNPEYAKVVAEHSELVRLLQSVAKVCNEAKKDNSMFFELNETFAENGPPILAQLKLKEQRLLQQNTKKDFELLQIGDLVAKLCLNVVPEGHWKGALNELLGEKVHLLPSDLAEFIIKMNSMTEQQLGSPKAYHRRMRRGDEAKMSGTRIRFQVVLGIQKYLVSKSTVLGIQKLMDPNNGWYDAKNDTVILKAEVTADKPIGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GNY3</accession>
    <name>A0A914GNY3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GNY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10082.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10082.t1"/>
        <property type="gene ID" value="Gr19_v10_g10082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10082.t1"/>
        </source>
    </evidence>
    <sequence length="576" mass="64707" checksum="AB9C34C0F2B1E611" modified="2023-02-22" version="1">MANDNNANEQYSWMNDALDDNGVGSDGERFSELIADTVGGRTRAELAELQRQAENNRAEINRTQNQFYAEQQQQERVESRDRRPSDRAPSVVTLASRSSGGAGDNNNSNVSGTTSDGLSTLGRRIQQHPYPGDGAKRLLEMVQQPFFVRFGDRGLSSAREIEHHRAGSSTKPLISPFLKDAEPEILHDSPRRVRAQTVGTQTPAIPSALSRPASPSPRRTHSLSDYPPLYDFSRRPHIRPPSTVRTTPSIPDSVYRSSPTRRSHSLSDYPPLYDFSRRPQIRQGTLGSAYRNAAPDPNFYRRRFINSLLKDIRRNKDLVRKLEGRQEELDDACRRDAEELSIIRRERELLVRELELQSREHELEEYERRRVPPQPILKHSASFPPNGSSSGGSNSNNRVNFASPICTAKEYTPNNSSSLEVSGARMPPPSRVMTGVQPVQQPPPPRTGVQPVQQQKQHHQSGSGNGQRCKHPLHHRRRAVSSPAQNGHSSRRSRTPSPAPRLRAADVNREREQEQQRVAHEAEFRAVQQRAHLIAVDQHRRATAARRPAGGPPVSRRNPCSNPVNASSIFHFVPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GP45</accession>
    <name>A0A914GP45_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GP45"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10119.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10119.t1"/>
        <property type="gene ID" value="Gr19_v10_g10119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10119.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39714" checksum="12A8679279D3B943" modified="2023-02-22" version="1">MSDNATEEKQQQQMEGIFICADVWLEVFAFLDPFELGLKMALISDRLDVLVDVHFKSREWSLGSMEIRCADDGNSAEIVKRYGGERLPIPQGPFPGKVIGFESIWISYVDQTVIEFLQRIRPLFDSSGTTVAIYTEEGENRSLEIIWQKIWPLINDNISRLLLVTQFDRSRQFFPAILCNCANLRMIDPGGLSPEFSADDNANASSRQVAAKWVLTPRGDGLPKMLRCRFYLAGMMEGLKRSFVNASKPVNYVISFLADDDFVPVPFELKNNLTGERLTFRWFYDEEWLLVRCPIGQEEAKWAEWEEEAIQLEMDNQWNRISINFQDSDIGDDMFEANAGPNECKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GP81</accession>
    <name>A0A914GP81_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GP81"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10074.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10074.t1"/>
        <property type="gene ID" value="Gr19_v10_g10074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10074.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20521" checksum="8964B8E687B39C6E" modified="2023-02-22" version="1">MPRATISPAFGHNFLSAIIFIRKLAGECRLGRKDNPSEDYSSVKDNPSEDYPSVDNPSGDNSSVKDNPSEAIRDNSSVKDNPSEDYPSVDNPSGDNSSVKDNPSEAIRDNSSVKDNPSEDYPSVDNPSGDNSSVKDNPSEAIRDNSSVKDNPSEDYPSVDNPSGDNSSVKDNPSEAIREWTIRQGIIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ36</accession>
    <name>A0A914GQ36_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQ36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10385.t3">
        <property type="protein sequence ID" value="Gr19_v10_g10385.t3"/>
        <property type="gene ID" value="Gr19_v10_g10385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038077149" evidence="2">
        <location>
            <begin position="17"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10385.t3"/>
        </source>
    </evidence>
    <sequence length="327" mass="35792" checksum="7EE0E45BBE2C2041" modified="2023-02-22" version="1">MKIFLLIFIVQRIISARSADAIGARRGCPTERRKLAATLWLLPRKLVQIDREESIGRRFCQLLPILFFFLPALIASSSSHSTPLPTSHGCPSEMLQKCAEPLQQLGISSGKNLVLLLLQLHSPNQLRKSCLAYATALPCFRNLVHRCGVPSQTEILRQMENAHHFLCSPFSAVEQSHLLAHRVCIGRVLGEVGGGANCAGGGQNSSAMAVVLFRCRERCLAAAGEMSESAKFGCLLRAKCGREAAAFYTKMQRKIFHKKFPLICEPQNSRELAATAQIVVQSVGDEQKKSKKEPTAETKAAKSQSVTSATVPSQPTIFVISKVAHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUH8</accession>
    <name>A0A914GUH8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUH8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1145.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1145.t1"/>
        <property type="gene ID" value="Gr19_v10_g1145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="323"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1145.t1"/>
        </source>
    </evidence>
    <sequence length="832" mass="96192" checksum="22596A50A27A18F7" modified="2023-02-22" version="1">MRKRAEPLTPWPNAKDVFEGFLHLIRFVKTLVVEDFDLSLVKLALLTFYEFQKHKTEKDQSAPFLFSAQDTLLLDALELCFRLKAKHIDVVGSVFRLKNKEMLDIAVNRINELFSKDIAKAVAWIVYLNLRDHFAFKTVVCTLILENQTALLYPFIGEDQYRRTKMLGDDLEQKIVSNHKHLEKLTRKFVKNFQIADSEVPNLMKLGTQNALLYNHYRWRKREISWSQFEEIARHAMMPCPDVRDRYFRRLFDEGLPREACHFAEVLGVSEERYIPQLKQFYQKNPDIVESIRGDIISSIAISKQNQELEEQNTCELYPGYPIIVTDTWDKLEELIAHLRDDGEELFGIDAEWRPHFLSATEKISLIQIATTKAVFLVDALLLETEGRMTESQWLNFFDALLCTEGPRKIGYDFRNDMRVFRSTFPFITKLFPLVKNVLCMYRLLSKVKMYPDASSAVFDRLDVESPSNLSLSDVSEYFLDIKLEKTEREGNWSLRPLRLEQKKYAAMDAICLNRLFRKVAAKLMTLKNKELASALKQHALINLVDEQPAKSPTIIPLVSGQMVRIKEGEEDFILNVQKAAREIEHAAHGNLHGFRSIREVRFIADSMLFGLGKHLRKCGFDTRLIGERDQIVEFCKQSQNNGFVVLSTGKGYKQLDLQLRGGSHEVVCVPLATDGTTPPSLMIKYLLNELRILLRPEDMWSRCVECNKRAFVRLPKRVAQTLCYMNAVRHGADWLDIDEQDLKQCVDQLKAESVPFTADQDDNYETQQRMLDAEADEYILVEDQSNEICLCRNFAVNMLNRLVLADQCSSPVQFYACTECGRMQLNSASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWQ6</accession>
    <name>A0A914GWQ6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWQ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1205.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1205.t1"/>
        <property type="gene ID" value="Gr19_v10_g1205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="113"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1205.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35438" checksum="047E4D2FEB113807" modified="2023-02-22" version="1">MAQKLSSKAKIVVTDSTVSLKKLAAVGDVFQYSGHGQMPREMLLEKVADADALFCLLRDKIDEELLERATKLKVVGTMSVGYEHIDLEACRKRGVRIGYTPDVLTDATAELGMALLLATARRIPEAVRSAQTGGWKTWSPYYMCGKTLVDAVIGVYGMGKIGTCMANKMVAFKPKRIIYNNRRPVDSSPFEFVSFDALLAQSDFVIVCAAPSKENAQIFNRDAFAKMKKDSILINISRGILVDIEALREALRDGRIRAAGLDVTDPEPLPTDHPLFSMDNCVILPHIGSATYATRDLMASTTEQNICNFFQGIEMVAELKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX73</accession>
    <name>A0A914GX73_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GX73"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11219.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11219.t1"/>
        <property type="gene ID" value="Gr19_v10_g11219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="272"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11219.t1"/>
        </source>
    </evidence>
    <sequence length="529" mass="59909" checksum="059F0E57289737E4" modified="2023-02-22" version="1">MAEDEVDDLLEEAFKNVDEAEKNGTKMDDIIKKKAKEVGIKSADSDSKRKRSRSGSRERKRKRSRSREKKKRDSSRERRRSSPSENSKRSRHRSSSRDRRRSRSRSRDRRRSPIARRRSRSRSPLEKRRSPAPRRLPGPERRDVMPFTPRRSPPRDARMDMTSEERDERTVFILQLARQTRPRDLEEFFSSVGHVRDVRVITDTKTRRSKGIAYVEFWERDAVPLAMGLSGQKLHGAPLVIQMTCAERNRAANAVAAANTIGLGLGLSSGPLQLCVNNLHPNITDDMLAAIFEPFGRVERCYVRKDPSDLSNGTGYVTFRHAEEGRRAMEQLNGFELAGRNIRLTTVDENETNAKEVKESTPKEASLESEDRNVNSSSRLQLIANLAKGKSDVELPKVTQEAIAAQQAHQQNADKIPIFATQCFMLTNMFDPSKETEPGWDLDIRDDVIEECTNHGGCVHVYIDKASPQGNVYVKCPTVAIAHKSVVALHGRWFAGKVITANYVPVASYHELFPDARTVTALLQTRPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXN0</accession>
    <name>A0A914GXN0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXN0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12304.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12304.t1"/>
        <property type="gene ID" value="Gr19_v10_g12304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12304.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15865" checksum="19EEB7A52F159E66" modified="2023-02-22" version="1">MNSRTSSSASFDLVAQNENDVVDTLHGQNHEIEPNIDKESTADQAEAGQLEEMKQLKGEVIAKMEEFQKQQQHNIDESAKMEQLNMDHLQSDQKQMSAPVDQGTSQLNGDRSAKIVEECQKQQQQNIDALTEARKGNGGAIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYF2</accession>
    <name>A0A914GYF2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein VAC14 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sugar transporter SWEET1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities. Interacts with NOS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYF2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12345.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12345.t1"/>
        <property type="gene ID" value="Gr19_v10_g12345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000004">
        <property type="entry name" value="Sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000010">
        <property type="entry name" value="Sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="19">
        <location>
            <begin position="431"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="19">
        <location>
            <begin position="515"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12345.t1"/>
        </source>
    </evidence>
    <sequence length="859" mass="97157" checksum="D53F621C69040F3E" modified="2023-02-22" version="1">MSDNQHHAPLSQAIVRTLTDKLYEKRKAAALEIEKQARDYVRNDNMVDLERLIKVLEQLATAPNGNTRKGGLIGLAATAIGLGNKFAIPYAQRLLEPVFACFSDADSRVRYFACEALYNIVKIVKMAALEHFEQLFDILWKLSSDPDQNVRNGSELLDRLVKEIVVSKHGFDLEALILLIRERIYSVNSSNRRFIISWLYTTLTVPEFSIGQYFPEVIDGVFKALEDPSPAVREATITVLTEMLHKLEPKEGIPPVDICSIVNVLVVQANSQTDTTRELSVQWMDQITVYYGDRILPQLSSFLLSILPHLESGEQGQIARSDQLNQRLTELLKFDSPIPVEPTVEVLLAHLRHERMETRMATLNWIRHLHSIQSNNMFRYMDRFFPILLELLSDPADDVLISNSWTYVLYGLARSLTKSVALLKMFKDDDKLIDERGIHIVRQVCLLLEPTDVFRSLALLLGTTSTTMSLSMNTKDPFPDLQFVAKMVRILNQILMTTSCFPFGSDSVARSKMIPICLLSLYLLSQNYQHALELIPRLSEIDITFELLTEVDRVVQLIESPILAYVRMDLLHPDHQKPLSALLSALLMLLPQSDAFAVLQKRLQAVPHLAVLDGMKKTGRPPPSVPSSAKIKFKELIQHFDKVTAIRLNASRFSSININRNLLSFTATTSTVGMFLCGLQICSRIRKRGSTDGTGVAPFFLTSVSCICWLGYGLLRRDQTVIFVNGVGLVFQTVYLIYYYTKTRLKSRLNRLIFLEMVISVITAMVINGDLLNENEKENLLGVVCMLLNIATIASPLVDVGQVVRTKSTESLPFMLCVANMAVCVQWLFYGFLVDDFYMKLSLFIIYPRTYKQLAVGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYM8</accession>
    <name>A0A914GYM8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYM8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12398.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12398.t1"/>
        <property type="gene ID" value="Gr19_v10_g12398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12398.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="51491" checksum="2E8F1C9B8484F1AF" modified="2023-02-22" version="1">MYLFPHLQITQNQPENLVEYSEFNQDRHRAENSYRLISNQTQKTSARHETRIAPPHQKNHYCHQNDTSHPFNLDQPPTVFQSPTFENGQNFNPKDYGGDQNFQFSQNKVVDRHGNDRYQFEERKGNNPVHSFEAEEHPNFRKALKQVVNRYGDDESNVYLAYLLALNQPNSHSHQTPRETSEYPTQPQNAPRREWTADGRDKKVNRYRAPNQNFRPANGRENSADPYGMPQRLNKVREGRGVRKRIEEDRQPNWNMESCSDGENLLPRKDQLSEPRHLHNPNSLTACPSGKDLTALHSADPVRLSTFSVIPCRELNKNVDSHLYPEVNKKFEGSPDKIPEPRIEEANVDWTLKGKEKEEQRQEIVVKFVTPTLGHAAAVSSPFRRSSTTGARGTSRGADRPVRTLADRIDPLRTSILRAIDSIPQAPTPKAGPGITDQVQRFGVRGVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYN4</accession>
    <name>A0A914GYN4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYN4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1200.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1200.t2"/>
        <property type="gene ID" value="Gr19_v10_g1200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF11">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1200.t2"/>
        </source>
    </evidence>
    <sequence length="321" mass="35473" checksum="D77D88BB5EF0A86F" modified="2023-02-22" version="1">MPIEGQTSSTSACKNGIFRRAQSLRFPRSSATAQQHHGTFTPGTSSTPSTSLNRHGSRAYRSKSSRQRYGSIEVQSLLSRMSSGQRLALCSTWRQMRHQLTTLMRKILVELEQHEPEVKDIFYKAQYVDCFASSSSTGNLATMDEHVRLMAKFFDELIAFVEMAGPSGTEGGEEITSMIKGVGQQHAILAHSSGLSAEVWEKLGEIAMEKFCAVEAVQKTREAGRAWRTLIAFLTDKIRCGFEGEAKAFCRRPSNEQQQQNATENGTAAETDDGGAMGGRFEMLGRRLQQLRTTDCDWTPAEGPNRHGGTTASANGRIRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYR7</accession>
    <name>A0A914GYR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYR7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12367.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12367.t1"/>
        <property type="gene ID" value="Gr19_v10_g12367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12367.t1"/>
        </source>
    </evidence>
    <sequence length="537" mass="58341" checksum="4A70189EA1B67FFE" modified="2023-02-22" version="1">MSQKVLDEQNPSEPKNGRVVVVVAEEGSKVDDGHDKPTVGGDGQAEEHGEKGDRTFVLSSPMEVNSAADSAGGLAEEMGGEAPNGEEKVVGDQRQENAEGEEQPSEGADEVGGGRERTETAQIGTGADGAQPLPEKTPPKLRIHRVFRNEEGFEVRQSETVADTRLVEQYLKMRMLCSREQLWRFAFDDANAEKDFRAMRRRLQKRFKYYENKQKLEVTTKKAAGKRAGEGETAEAKVRLGWTARNWEGLGLVWTARKVGKGWGWAGLPKKLGRVGVGLDCSKSWEGWGWAGLPEKLGLAGLPGKLGLVWTARNWKGWGWSGLLEKLGLVWTARNWKGWGWSGLLKKLGLVWTAQKVGVGLDCPKLGRVGVGLDCSKSWGWSGLPEIGKGWVGLDCSKSWGWSGLPEIGKGWGWSGLLEKLGFDWTARKVGKGWGWAGLLEKLGRQKALIAANNLRPSTSAAVQSPFRPSPPSSSGYSTTTTTSSAPEGKTPPAVGGRHGGRGTARRPNAGTKRQRYSPGAEALNPQQEVRRAKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZY6</accession>
    <name>A0A914GZY6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH helicase/translocase subunit XPB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA 3'-5' helicase/translocase XPB</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZY6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1235.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1235.t1"/>
        <property type="gene ID" value="Gr19_v10_g1235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="321"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="514"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1235.t1"/>
        </source>
    </evidence>
    <sequence length="756" mass="85385" checksum="E2F6884C7EED335D" modified="2023-02-22" version="1">MADKPSTAGGVVAPKAASRRLDDPSTSAEKEDEFGARDFRSEVQLKRDHSSRPLWVAPDGHIFLESFSPVYKHAADFLIAIAEPICRPEHIHEYQLTAYSLYAAVSIGLQTGDIIEYLDRLCKHSLPSGIKQFIEICTLSYGKVKLVLKKNAYFVESRHSDIVQRLLKDKVIQDCLVADEGGRSAAGAAETVLSKEKSQIVGFAVQSAAKKSAATANQTESATVDGTAAEKEVPEDIDQFYEKLTGDREEDDSEALRNLEVLTFEIRQECIETVQKRCIELEYPLLAEYDFRNDTFNPNLNIDLKPTTTLRPYQEKSLRKMFGNSRARSGVIVLPCGAGKTLVGVTAATTINKRGGPSSNFGRPSRTRRSSDLLAMLVTSSYSMVAYTGKRTYAAEEAMRYIESLEWGLLLLDEVHTIPAKMFRRVLTIVRAHCKLGLTATLVREDDKITDLNFLIGPKIYEANWMELQKAGHIAKVQCAEVWCPMTAEFFDYYLKSSINRKLLLSVMNPNKYRVCQYLIRFHERRNDKIIVFSDNVFALKRFAVQMSKPYLYGATSQAERMKILQNFQYNPKVNTIFVSKVADTSFDLPEANVLVQISAHGGSRRQEAQRLGRILRAKKYSTDAFNAYFYSLVSQDTVEMNYSRKRQRFLVNQGYAYKVVNEFPDMIKEMLDFGSKDEQLKLLSQVLQASDADTMEEEMKEEMLDGGSGQSRAFRKEADMAAYSGANIVAYTTIQKGGGKRNAEERHPLFKRFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0B0</accession>
    <name>A0A914H0B0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0B0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12759.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12759.t1"/>
        <property type="gene ID" value="Gr19_v10_g12759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12759.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7909" checksum="9D30CCAF916CD2BE" modified="2023-02-22" version="1">MIIDFFKINHSKPAADNCKQKTTVHRTPARINLAVDENFVRREWMDSNWNFSIRTTRSISSYVFGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0E8</accession>
    <name>A0A914H0E8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glucosylceramidase</fullName>
            <ecNumber evidence="3 6">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
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        <property type="gene ID" value="Gr19_v10_g12896"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="Glyco_hydro_30"/>
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    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="8">
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            <begin position="140"/>
            <end position="481"/>
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            <begin position="96"/>
            <end position="115"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF02055"/>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12896.t1"/>
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    </evidence>
    <sequence length="666" mass="74109" checksum="DFDF5426557A562F" modified="2023-02-22" version="1">MAKFEHSTKLFIYFFVVILLPIYYCESHNLLNKYQCQQRRFPNSDSFVCVCNGTHCDQPNPFDGNLLIGSDEAIVYVSDREKYRLNQCLVPIKTAEGGPKRASSTGRHQHIPKCEKEKDQAEPKSWLHIKVNASHVYQKVQGFGGSFTDSAGFNVQKLSSATQHILLSTYFDREAGIGYSLCRVPMGGADFSVRAYSYAETPNDFELKKFALAKEDFEWKIPYIVEAQKLSGQRLQLIASPWSPPGWMKSNGHTIGFGTMKGSLHGPYYQSFARYFIRFFEEYQKHNVTFWGCTLLNEPFVGAKPGMYMNATTQREWATEVLAPTLKQSKFKDTVLMAHDDNRNNVLESAIEIFGNQTDSPISGLTFHWYSFGYYDNLSRIHSMFPNKFLIGAEASAGFEGAQKGVSLGNWDRAVQYGRDIIGDLQNWATGWIDWNLFLDQNGGPNFVNNFIDAAIIVNAKNDEFYKQPTFYAVAHFSRFIPPQSERIDATFETPTLLEYFPAVSLYLPSPNPVDFVAFQTPPHGNRVMVLLSNRDEAIGVKIHDGFRSVDQSYFAIDEVITTNQLGTNLALNVNAKVERADALEGSATVGGKSLSRAKRFGYNGWGGYGGCCCCNGYGNYGGYGNYGGYGSYAGSGSYAGYGGYGPFGVGLAGLTGGLLFGGWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1B2</accession>
    <name>A0A914H1B2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Rabphilin</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g12332.t3">
        <property type="protein sequence ID" value="Gr19_v10_g12332.t3"/>
        <property type="gene ID" value="Gr19_v10_g12332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017158">
        <property type="term" value="P:regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061669">
        <property type="term" value="P:spontaneous neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04035">
        <property type="entry name" value="C2A_Rabphilin_Doc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15746">
        <property type="entry name" value="FYVE_RP3A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
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    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
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    </dbReference>
    <dbReference type="InterPro" id="IPR030541">
        <property type="entry name" value="FYVE_RBF-1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043566">
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    </dbReference>
    <dbReference type="InterPro" id="IPR047022">
        <property type="entry name" value="Rabphilin_Doc2_C2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729:SF6">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RabBD" evidence="12">
        <location>
            <begin position="415"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="463"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1143"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1267"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="698"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="734"/>
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        </location>
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        </location>
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            <begin position="1043"/>
            <end position="1077"/>
        </location>
    </feature>
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        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
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            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
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            <end position="584"/>
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    </feature>
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            <end position="609"/>
        </location>
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            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1411" mass="152997" checksum="03C590C933677017" modified="2023-02-22" version="1">MATNLSRKQGHCNFRADGGDDSAEPAASGLAGVNSSPPSPGPVQIAYEYERHCCHWTAVASTSTIATALCPHQRRFCSVSSPSLLRSSFRIPPNSATNNRRHPADFLSSSHCQFLAVPAIAIQRIHRRMSAYGSAEMGRGGADKRKKKHPQLLRLTGQRAQSCTDFSNRLASSALPPSSLAAAALSAKHIHESGWDSSELFAPFQPIPPSLCSVSGSAPASASATDSASTNIFKNKEMAAKCLNSHRPLHSSDSGSCSAPPSLSPERKTSSARLRSSRFCCSFRRTLKRTPKRERCGDKKESVASMAHPSPEESQLLARAWSRKESRTLILPDGPRAGNRRERVDSCGAGSVAEGGERSRESSTFSHLMNDWEIGGTPNPWVCPSDRHLQLRAQLKSGWSVRTANARSPTTSKQALINGGISEAEQAQIQKVLERAEAGRQNEQQRICKMIERLERLRARATGNGVTQCLLCQTEFGLLAAKSYAAMCSDCRKYVCQRNCGVETFDQKRREPIFLCKICSEYREVMWKKSGAWFYREVPLPPSSSRPASAMAGSITMMVNGGPASYLPLSPSARSNPPLGSQTGPMARRHFDFGGGHQPRTDGRSEQHHQQQRNRAPVPIPMEQQQRLKTTPRPRIIPSWVHDGLQQSSVSVDDDSDGESASSSTSSSLEPAQFRKSLVAAKERALSVKQHAAAHAFGGHASGASGGVRTNKTKHGGAGALVHLGTQKLQRVALGRAGRMSDTDSENERGGYCDDAVSRRSSPSTSPRHSLATPSSFGGDDIGQNAQNGAIGATRGSDGTGACGEQTLSDSRSVDSGVVQSDHSAQQQATADGLVAYAHSQFIAAPSPHDQPFFQQRLPAQTPSPVPPPIPPRSATIAATPPKAVLSNTASPYHTHFPYPPSRRPASAAATPSATSMIKLKGSSGGNHSGSSHESIPARVGGAASRGMGSGGMHGHGEHAPMTAATSSASLAPEVFGDSRRSTQSTAPPTKEERAELEQTAEGLEEELDNNNSPDSPTFMNSPEDDSKHLRTLSSRRDAFASLRPISSNSASSPTRAPCHKTQSLGTSCQSQQQQRRRYPMLMHPSVSVESAQSDESTDDPQHIAISRNNGTELHYSPHLALTTPKRPHSANSLPTIDENSGTLGSIQFNLTYLVAEKQLIIHLIRAQNLKAMDKNGFSDPYVKFHLLPGNIKATKLTSRTIEKTLNPEWNEEMIYYGITEEERQRKSLRVTVLDRDRIGSDFLGETRVALNKLPLGQTKKFNLYLEHAMPIPAHEKGFAGTNKDTGSLFVIIKRCAELLGMDSTGFSDPYCKVSLTPLATKAHRLRTTIKKRTLNPEFNEVLQFIVPFKDLPRKTLVIGVYDYDVGRHDDYIGGIVLSTAAPGERGRQWQQVIENPGKTFEHWHRLEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H373</accession>
    <name>A0A914H373_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H373"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13434.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13434.t2"/>
        <property type="gene ID" value="Gr19_v10_g13434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09366">
        <property type="entry name" value="LIM1_Isl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000041">
        <property type="entry name" value="insulin gene enhancer protein ISL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047169">
        <property type="entry name" value="ISL1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047244">
        <property type="entry name" value="ISL1/2-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204">
        <property type="entry name" value="INSULIN GENE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204:SF8">
        <property type="entry name" value="TAILUP, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="388"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="390"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="446"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13434.t2"/>
        </source>
    </evidence>
    <sequence length="589" mass="64062" checksum="E579DB94E9760170" modified="2023-02-22" version="1">MTKSVRSPLHQLVDRPSSSSPTPNERASSNVENGQIRASFDGPTNFDLKLQQNSNNAFSSPALALFPSFKFPLDANKQIMPICAQCSQAIVDPFILRVHPDLEFHSDCLKCAECGRLLNENCTAFLRDGKTLCREDYIRLFSRRCPRCDVQLRPTDMVLHARQLVFHMNCFSCVNCQRMLVPGEQFLLYQDEIFCRPDCFTVMVHHQQQFHLFNGQHMPPPPQIPHQTAEFATLQPPPNIGDAPPYELATLGNGGTAAIGTQNLGGGGNFLPSTFARPSMGVPPNCSSVLSQMASSGASPLSFSNPDESLTPSSTNASTPTASNGAIGGGQLHNGINTNGGGMLQANFEAIGTGCSIGAHFASSAGRGSNCSSSSSSVIVHKGKKNKKDKPRVRTVLNENQLKILKQTYHGNQRPDTNTKEQLVEMTGLNARVIRVWFQNKRCKDKKRQIEQREKQQSQEKDQTIRSVRASGLGPMTVCSPGPAQLVDPQQSCGGGSQQQFLAPVEIRQFSQKNVRHWSDPPIGEAMDGTGAAGVPAPMDSLFHPNAPPSMMMSNGGTSLEFLHPPPPNPNFQSLSNGMQLFPQQAISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3J3</accession>
    <name>A0A914H3J3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13667.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13667.t1"/>
        <property type="gene ID" value="Gr19_v10_g13667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="503"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="1063"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="1644"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1885"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13667.t1"/>
        </source>
    </evidence>
    <sequence length="2120" mass="238386" checksum="F7A8064A7FB55618" modified="2023-02-22" version="1">MDEEQLRERLINIEEPNAANELNLEDEHRLLDQGFGNRTLNGEEIRTGNRGDRVNIRQNERAENARLQNEENFITSTPISPIRASRNQYNLHARNQGAPRASRPRDARGRFLRMPSNVQEGNFANQNANINPAHQSNFGQGGSSNEAGREGVTHHQQARANHSHASTQSQQQFELQAPIQQQPQFGLQAPMQQQPQFGFQAPVQQQPQFGLQAPVQQQPQLAPGQQQLQFGFHASVQRQQQFGWQPPVQQQAQFGMHPIFPIPAYGYQIPAQNPGQFFSNPGQGTIPIRDANGRHRVDKWLLTMNSRFILQVEYQPGKKNIIADLLSRSGALASKEVSDESSIPPANEIAHIEEIREGDEPDSGGEIVSEQRKEWILKTKEGELGFIYEFLESKTVPKEPKEQQKLMSSLHKFALIEGLLYRHGEDGKAHLFVPRPFREKMIRERHSGTCAGHLSGKKIFKQLAEGYFWPNMYGDCIRAAFCCRVCAHARKPRANEPPLNVVKTSEPLELVCIDILSIGPANSSNHYILVAVDHFTKYLVANPIPDKSAETVARNFVKKFILVLGTPKRLHSDKGKEFVNETLTEIASTLKIERSTTAGYDPQANGVTERVNQTIIGMLRRSTTSAWEWDDRLPYIVFAYNTTPSETTGFSPHYLMFGKPANFPLEKEISLLKNPLYTVDQDTYIQLFRESLHQLIEEARKNSEVARRKMKERYDAQPKVTAAKFGIGDRVMIIVPGAHARSPHRKILWNHFGPFVVKQITKSAGIVVPADKLNAEPLTVPLERLVRVPPGITNVCTMPKGKNPYKNILNGLISAVALKSQLKIRDSFLATQGRAPSQFVMLTDASKIGIAAILCQPDEVGHLRPIYFASRQCNRHESRYCPTELEALAIRFVEYQPGKKNIIADLLSRSGALASKEVSDESSIPPANEIAHIEEIREGDEPDSGGEIVSEQRKEWILKTKEGELGFIYEFLESKTVPKEPKEQQKLMSSLHKFALIEEKMIRERHSGTCAGHLSGKKIFKQLAEGYFWPNMYGDCIRAAFCCRVCAHARKPRANEPPLNVVKTSEPLELVCIDILSIGPANSSNHYILVAVDHFTKYLVANPIPDKSAETVARNFVKKFILVLGTPKRLHSDKGKEFVNETLTEIASTLKIERSTTAGYDPQANGVTERVNQTIIGMLRRSTTSAWEWDDRLPYIVFAYNTTPSETTGFSPHYLMFGKPANFPLEKEISLLKNPLYTVDQDTYIQLFRESLHQLIEEARKNSEVARRKMKERYDAQPKVTAAKFGIGDRVMIIVPGAHARSPHRKILWNHFGPFVVKQITKSAGIVVPADKLNAEPLTVPLERLVRVPPGITNVCTMPKGKNPYKNILNGLISAVALKSQLKIRDSFLATQGRAPSQFVMLTDASKIGIAAILCQPDEVGHLRPIYFASRQCNRHESRYCPTELEALAIRFVEYQPEKKNIIADLLSRSGALASKEVSDESSIPPANEIAHIEEIREGDEPDSEGEIVSEQRKEWILKTKEGELGFIYEFLESKTVPKEPKEQQKLMSSLHKFALIEGLLYRHGEDGKAHLFVPRPFREKMIRERHSGTCAGHLSGKKIFKQLAEGYFWPNMYGDCIRAAFCCRVCAHARKPRANEPPLNVVKTSEPLELVCIDILSIGPVNSSNHYILVAVDHFTKYLVANPIPDKSAETVARNFVKKFILVLGTPKRLHSDKGKEFVNETLTEIASTLKIERSTTAGYDPQANGVTERVNQTIIGMLRRSTTSAWEWDDRLPYIVFAYNTTPSETTGNIPFKKPLYTVDQDTYIQLFRESLHQLIEEARKNSEVARRKMKERYDAQPKVTAAKFGIGDRVMIIVPWAHAYHRTAKYCGTISAHSSAAALIDRESNRGEDEQMDADGEQETEREGKAADVLSLGTEDGMEEKRSAPNSALWEVTCSGENHKSCTPLVVADLDAVLDRSGIGIKAIDNPLKALMTTFLFNADAGWEMATYCGAREDDVKSGAFTSERDVEDTLREWLDHCHVAREEVKKSGFGPFAMEIPEALITLPEAEREGMRKVFESVPFILERVRSMIVFKRPNFVTEARVLLGDSNALQLKKLWAKSAFVGVQEGPIAEVIRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4G8</accession>
    <name>A0A914H4G8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein transferase MAEA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Macrophage erythroblast attacher</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H4G8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13563.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13563.t1"/>
        <property type="gene ID" value="Gr19_v10_g13563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043249">
        <property type="term" value="P:erythrocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0265">Erythrocyte maturation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="11">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="12">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13563.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45482" checksum="CAB3436E66B5F966" modified="2023-02-22" version="1">MSGKALTNFNELNCLEYGTLKVPYELMNKKFRATQRAIDQCNFHFQKEFSVVEQKLKDRAQPIPLSEVSECVQKLNKIVAQFKQDIELRVAGEISACEDLSRCVGHLSEANSAEETARHFFSEQRLNRFIVDHLLRTGHFASAQALADFVGLDIQAQRDVYHVAKQVEESLEQHDLGPCLCWIRDNRSRLHRIGSSLETEVRIQQCIELIKEGHTIGALKYVQIFFGSRSDIHGAQWAVNANLLHLMGLLALGKDSARSEHQPLLSDDRYQTLITLFRMENERIYKFSNKSPFSACLQAGIAVHKTPHCTKQPESRCIVCSSVFELSEGLPHTHLTNSKLFCAISSEPFDCEENRPMMLPNGFVYGEKSIRTRAVNNEFKCPRTLQVCSLEDLQRVYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5M3</accession>
    <name>A0A914H5M3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5M3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14048.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14048.t1"/>
        <property type="gene ID" value="Gr19_v10_g14048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037447936" evidence="1">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14048.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="11323" checksum="E378C5F9B5F33B75" modified="2023-02-22" version="1">MNSVKMFTLLLIIGTILALTICMPTGKDESVSFVRQRRGYGYGGGGSGGGGGNGGGFGGGNGGGFGGGNGGGFGGGNGGGFGGGNGGGFGGGNGGGFGGGNGGGFGGGNGGGFAGSNGGGGGGGGGYGYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5P3</accession>
    <name>A0A914H5P3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5P3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14232.t4">
        <property type="protein sequence ID" value="Gr19_v10_g14232.t4"/>
        <property type="gene ID" value="Gr19_v10_g14232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14232.t4"/>
        </source>
    </evidence>
    <sequence length="999" mass="114750" checksum="F97F6AB12FA5F30A" modified="2023-02-22" version="1">MQHRTCAFWSDLLRSRCKSDQTKNVTDNNTDSDHESLKMIAETVLMECIDQRNVSVGCLAAEFLFRNGDKHFDAKTATNCPITMSGYLNSLVVKNCNDGTNNNNNNANALCHFLAHILLQFDCRIPLHSLGVLVKIVKAHLHDASVVEQTNTGRLIQLWHQCFYLERGGPNELNKLIAKNMITILQRVGPPPNELFKHLLFRVPHFIRHKYLLMQYLLSDSPLDQVKIKMPNLVGGCFVNLDEPVLLTFFDQLASCLEGRGCQADLADAFHALAIRFLELGKSELLMQLISKTLHSNNGPTRENAIRLWLPKLNTSQQLRQMFVALLDSFRVELHNNLSTIKEEENEASVSAFDQSPPYWDYGSFVDPCVHWTQQQINLWSFVQLFYWTAKNRVPLLHAQMSEDVEIVVNALIYGHKDEIKQIAADSLLLLLQRPKQHLAKTQAEHIIRRFASHFEHLMRAENAKLCNSVNSLIVNLLKFYDQEDNAVILLKCRFQQLLNNCTKNIQSPIFFCPITGNLLQLIERMDDDYCSTNEELQLDVQNFLLKALVYKNDSTVRQRSALIASRIANGCSQFRSELITLFNESAPNLKYGIAHLYRLILCLRVDERDLNLHFVGDEDGLTILFKRIKFEQQNQLANENDAIAHFLSHCVDVNEKLLQIGGSGRPAQCVTVSELHLLFEKCSVEDGENDDDLLFWSDLQRRQLAIYSNGIIQSCSALRWILTKFTNQIDAFAIQKGLRSIWTVLLRSHHKGVLEHCAVRDKINEKTLSILFYGGGQCRNIAFAKILVPIFASLCAKRRTDFVKKLIFAFNLPQNSIMCAFDQTKLQLHQLFLLKQLVSTTKFDLRELRTEIFQFIIQMTRLAMNKGQTERWRLFSMAGNAFAALLNSIFRHFPDIVPLHNFYVVERCFCDNLLNFLRNIRIDLTQKRRSEPSIALLLVPLQRLFVVDDPFETYAPANGFVAEVCLELNLLMRLEPSVLLRRQMEQVITNFKGHPQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H685</accession>
    <name>A0A914H685_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H685"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14564.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14564.t1"/>
        <property type="gene ID" value="Gr19_v10_g14564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037622378" evidence="3">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14564.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24938" checksum="019F1AB894ADFF1D" modified="2023-02-22" version="1">MAQRFVNIVLAFAFFIEPVALQDNRLRCYQGIIGAEVPYELSLRLAKLDISHGPDMTECVSDDRVCTFFECKAQDWYFASCSRQYAFCSFEMHEYCAQDKCQTCHTDHCNLPLSMRPNSTTTTRATSTSSVPLVMHSNSTNDDDQSKTTHIPETTMQDGHNKTNSENGTSDQVQVVEVPLAQKGNGTVKSGVLSAKVASLYVLALLLAISQAFLWFIEKMPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6E5</accession>
    <name>A0A914H6E5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6E5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14116.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14116.t1"/>
        <property type="gene ID" value="Gr19_v10_g14116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14116.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26307" checksum="4289771E741FE85F" modified="2023-02-22" version="1">MIDQYFFYSAKMAVVFFILVISSATLEAYQRNEKDKFFDLMTAIGEDFGGEFHEAEKALELDLNATNSFLERLHKFATRELVTKVKNGEFACKEATENSAFKEAIKTILGQNMRNLLKAIVVPKQSKTMIDKMIDQYFFYSAKMAVVFFILVISSATLEAYQRNEKDKFFDLMTAIGEDFGGEFHEAEKALELDLNATNSFLERLHKFATRELVTKVKNGEFAIGGIEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6F6</accession>
    <name>A0A914H6F6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6F6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13664.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13664.t1"/>
        <property type="gene ID" value="Gr19_v10_g13664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038009123" evidence="2">
        <location>
            <begin position="23"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="296"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13664.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="36945" checksum="460C08D479129F97" modified="2023-02-22" version="1">MATNALLVLAACLMLLPPLLVANGGGLLGLLLAEDNGGNAVNGRNRLHGGELLAELVGALGKGGGEDKKNGGTKADGNGTGKKGGYEQGKPLVDELAKNGFGEQLIDGVPLRFYAPDPNSDIPPHVLRRVMRFCSKHPTHDKCKNHPDWIIDEDVLPALPGLTDKLLEEFPTKLHFTIPARRPLRLEPLLKDVPDELVKALPVAKKLDAKSKQMLMNRCVGGLCKKQKPEYLNQRASLAELESVTFKSLFPDIPIESIDLAIEVRQRRVYEVKKALLKQAGLEEYPTNGATAQVSSSEEELDELQEIFPSFSKEVIRDVLETNGGNRELAVSVLIKMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8D8</accession>
    <name>A0A914H8D8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BK channel</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H8D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15162.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15162.t2"/>
        <property type="gene ID" value="Gr19_v10_g15162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="12">
        <location>
            <begin position="199"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ca2+-activated K+ channel Slowpoke-like C-terminal" evidence="11">
        <location>
            <begin position="426"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15162.t2"/>
        </source>
    </evidence>
    <sequence length="575" mass="63136" checksum="A3B3A888F2FACF77" modified="2023-02-22" version="1">MYTETMSHAFAGMRFRDAAELLFTRLGLLLLAIELKDDEKKECNIAINPGPSTVIQSQTQGFFIAQSADEVKRAFYWCKICHADVYDVSLIKKCKCKNLSLFRKGGKAMMKRASTAAGVISAGAQRVNNGFIGRSDPDTLNAGAGQQLINVDTGRVGGGVDLFEQQEMKYDSTGMFHWCPARLLEECILDRNQAAMTVLNGHVVLCLFADKDSPLIGLRNFIMPLRASNFHYHELKHIVIVGDVEYLKHEWKTLHNLPKISILNGNPLSRADLRAVNINLCIMCVVVSARIPNPNEDPTLADKEAILASLNIKAMEFEDTLSGIGVPVHRVVQGIPQQQQQSGTRSGGGRQQQQFWQRPPLGVLIGTNVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRGGYSTPDTLANRDRCRIAQITLSDQPYEGITTGSTYGEMFSIALKKHGQLCIGLYRLHDQASLDSNKRYVITNPPAELRLLISDNVYVLEQFDFGYSKFETFGSETGGGGGGTSVGSDRLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8F2</accession>
    <name>A0A914H8F2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitric oxide synthase-interacting protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H8F2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14696.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14696.t1"/>
        <property type="gene ID" value="Gr19_v10_g14696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16661">
        <property type="entry name" value="RING-Ubox1_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16662">
        <property type="entry name" value="RING-Ubox2_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitric oxide synthase-interacting protein zinc-finger" evidence="6">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14696.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36508" checksum="AF64C92BDFE7F312" modified="2023-02-22" version="1">MTRHAKNATAASVYTYHERRKDAQASGYGTLHERLGKDSMKPFDCCSLSLQPCREPLISPQGFIFERESILNYILDQKQAYKRKLKIWEQQRRTENEKKEAVLRREEDQMKAKFASLEAAPVPWKTEVPPATPAGARLLKRTSAALDDNLAGPSGAKARRSDDAYEPESVSNMAGHRAKEWRSFWVPELSTSAEPDRIEKPSSKMLCPISGEELKLKELLPVKFTPIDSRMPFAKLVAQPNRYKCPITHDELTNTSRCVYLKTSNCVVSWQCMDVIRKDMVDPLSGKRLTEPDIIELQRGGTGYAATNKLDAKLIRPQLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9J2</accession>
    <name>A0A914H9J2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9J2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15051.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15051.t1"/>
        <property type="gene ID" value="Gr19_v10_g15051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036839003" evidence="2">
        <location>
            <begin position="24"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15051.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26373" checksum="45DB346D8D2A816C" modified="2023-02-22" version="1">MEEFWILILVAFIATNSLDKAESVKVKLEETALKTFDEIFGEGWWDKGEAEDLKSPPTNFGQNVHHQIDRQNTQIGQIEPNSTDQNPPLTGSDHSDNAKNGKEITSNEKQKFDQMKAELKRAGFKNSYPNQIDKTVAKELGLSLATIYNWKNELGQTTPKHKHSHSEQKELMKRYYEIKCKNSKIRDENIAKMFKIARATLNRWKRQFKRQKFHPNSVDGHSVEENAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9L3</accession>
    <name>A0A914H9L3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9L3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14538.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14538.t1"/>
        <property type="gene ID" value="Gr19_v10_g14538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14538.t1"/>
        </source>
    </evidence>
    <sequence length="667" mass="72268" checksum="64EB091AEAE6A9C4" modified="2023-02-22" version="1">MYRRRASFVHHRHCSPPMRSAGGRSARHHSPPAAFRHANNDFRSPGPPSSTFRSRPPRGFAPFRVRAFCHHNRFRAVASAAPSVRAGFRGGRFAPPRAMPRGRPPPPRIPYHCRADISPRRSPCRSRSRSANTPPSTAATAAQHSSLRRSPSWSPPPPALAAERGARGGRNRSGFRGGGRFVAAGRSKFIGNYGRPINHPPAYEVSPDRTAPGASAGDDEIDAVQQQPAVEVLSNRDELYTKMMEAKKSENLDDYYRLRDTLNAFDVRNPHLAFRGSGATTSAAVTRKRSRSAGEKAAEPTAARKRKRGGGADDDGGEEDDHRHHQHRHHERKSSMTAPKKKKKTHEEGGAATAGGGGTTTSSAVGTADELEEVDSIDARYEQDKCNAKYVHGNAGGGDKRRKSAHERSAKQLKQRHSADTKSKSDSKCHRLQIALDSDAEKSPEKCVSRAAVVATSTAGRRRSWTKAHDERNGEDDVDEQAWLDELDDEEEEVGFDLVENEQLDNDDGGDGGGGPLPPAEKLDDDNVTASRDALQEVEEFAEVADEDDGEGGGGGECDYDAQSYGALFRPDFVTILQSSVAKGLRMRNTTTSSSSSSSNRRHHQQAGGTNGRQQQQNANANGTDGNGTGGTASVGQQEQQQPCTLVEMALARLVANTVEEIESSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAC1</accession>
    <name>A0A914HAC1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAC1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15253.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15253.t1"/>
        <property type="gene ID" value="Gr19_v10_g15253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15253.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8561" checksum="58BC3BB49E62ABEA" modified="2023-02-22" version="1">MNGKKVDFVIDSGTESTVLCEEAHRRIGSPLGWQHSRPEDGHTLDASLSLAGKLPAENAMMGMASDSDWKATALQFSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAE0</accession>
    <name>A0A914HAE0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAE0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14749.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14749.t1"/>
        <property type="gene ID" value="Gr19_v10_g14749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024491">
        <property type="entry name" value="Se_SelK/SelG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10961">
        <property type="entry name" value="SelK_SelG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14749.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="11771" checksum="B52B2D600AE099CC" modified="2023-02-22" version="1">MPYVNERGELQDGPSFSIVRSFWSLFYFFAFFVRSLFGPLINGAPRYDPDSAARHRSLGGNGRGGGGWGGGGGGGGGGWRPGGGGGGGGPRRPMGRLNNDGPSSMPSCPSGGCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAK6</accession>
    <name>A0A914HAK6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAK6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15324.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15324.t2"/>
        <property type="gene ID" value="Gr19_v10_g15324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00917">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="270"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15324.t2"/>
        </source>
    </evidence>
    <sequence length="394" mass="45332" checksum="C7CE7F17E80E9428" modified="2023-02-22" version="1">MDQKETNDKIGWLNDDQQKISVSVDHFLVGQSDQKALLDRLNGLEQKQTANSDHQKALRAMLDQGMNQLKRDLMATMGKCKQQQTIDVLAEKLNIAIDHFYRLQTTISDLEHKQQNDQKELLREMNESLCPINGRRRIRNWDYPLKTDGIPLHRILSIALGKIALRWADEKCRQNGKECSAENRREMLGPALFKIRFPRMPQKDFSEIIVPSGVLTPDEIISVYLHYSHPDADQPKLYPLQFPTKRRTATKSSGDGPYKANGHIMFTIEKVSEFARENENSRRFSEAVYIRGISWKIMATLQIVSSQKCLSLQCYAENRGPNWSWVGSATLRIISQKEGKKDFTQTMSDVFWPYPPLTLSFEKLMDPNNGWYDAKNDTAILEAELTADKPIIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBH9</accession>
    <name>A0A914HBH9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBH9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15072.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15072.t1"/>
        <property type="gene ID" value="Gr19_v10_g15072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036742114" evidence="2">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15072.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14275" checksum="F7B1C125FB29882B" modified="2023-02-22" version="1">MEKLWIFILVPFFATNSLEKAESVQLEETPHKIFDEIFGEGWWDNDKDEEWNKLTLEQTFLRQIDRQNTQLGQIEPNSTDQNPPLTESDHPGQIEPDLTDQNAPLTEILLSQSLITLDKLNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBX0</accession>
    <name>A0A914HBX0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBX0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15653.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15653.t1"/>
        <property type="gene ID" value="Gr19_v10_g15653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15653.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="21502" checksum="59E1D3F77B760214" modified="2023-02-22" version="1">MHSSDDRLQQQNEKVHAGNDVVQHQHQQQQNKVSSPSVRVALEATAVAVAVGRGGSVTAPTPPALSPRPPIGYMPPPTSPLCNNYEQQQQQQQQHTPAAMAVLSAPPAVVPYGSAGGGGDGPSLFARRRVPAPPPCFSPVRDSAAAAAPSFWLLPSPRAAGTFGLGSPRSPAPSTATSAGSNSSFLPLGTDVLALAHAATPEAINFMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCR7</accession>
    <name>A0A914HCR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCR7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15850.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15850.t1"/>
        <property type="gene ID" value="Gr19_v10_g15850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11722">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000009">
        <property type="entry name" value="Stromal interaction molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057835">
        <property type="entry name" value="EF-hand_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032393">
        <property type="entry name" value="SOAR_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037608">
        <property type="entry name" value="STIM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136:SF5">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25578">
        <property type="entry name" value="EF-hand_STIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16533">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="188"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15850.t1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48291" checksum="E375BC71F069CBB9" modified="2023-02-22" version="1">MRNVLITAEEEKLRDTEGFLAVKAIHAVLDDDNSGSIDRSESADFLKEDLKFGGSDKVRRENAFHSNDESITVDDLWENWFQSEERGWNNKQVVDWLTNQVKLPQYANSFLNAKVTGLDLPRLAVQNSSFLSNRIGIKNYVHRQKLQLKALDLVLFGFQDSSSIAKDIALAGLLGLLVAVLIIFKKHKNRSKQQMEELSSVLNKLRDMETDFAGVQNKLEEENHNRQSNNTEDSENIELLRSQLRELENERRIAEENGFGEGFPFALQPLLRRTYEMEWAYLYQQKLDCLHEMGEAKEFVDKMRRKQMSFVNSLKLATGATSGTDDIDNKIFSVKARMEKIKMALNECTHRWADIEALCGFSITESFVDNSISPPNFGLIPCSDFPPETFFDYSPFQYIQQQYNDNSATGRFSSSSSDAEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCY3</accession>
    <name>A0A914HCY3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-hydroxyacyl-CoA lyase 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IlvB-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-hydroxyhexadecanoyl-CoA = pentadecanal + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:55212"/>
            <dbReference type="ChEBI" id="CHEBI:17302"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:138654"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:55213"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16209.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16209.t1"/>
        <property type="gene ID" value="Gr19_v10_g16209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF166">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16209.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18512" checksum="75F9B3BC9E265BE5" modified="2023-02-22" version="1">MAWLDPGAFGTLGVGAGFALGAKAVHPDSPVLILYGDGACGFSLMDFDSFVRHRLPVVALIGNDACWAQIARDQVPWFNSSVGCELSYTSYDEVGRGLGARGVQFKEPTEDSEVRHQLGLALAKCLEGQSTVINALIGRTNFREGSISVGGGRRFRARRPKQQLVESKGIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD17</accession>
    <name>A0A914HD17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15916.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15916.t1"/>
        <property type="gene ID" value="Gr19_v10_g15916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15916.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14938" checksum="E00E6D32E56BCFB4" modified="2023-02-22" version="1">MNEMEIPDTFGERLQKFKDSGEPHMLHPENPDIWKPAYHEMMARRLSWAAPYDARFPQQRKQRQCFEYYVDYFRCQELMGEEYKPCKFFRNVYRDFCPGYWVEKWDELREEGRFPAKFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDZ6</accession>
    <name>A0A914HDZ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADPH-dependent diflavin oxidoreductase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDZ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1648.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1648.t2"/>
        <property type="gene ID" value="Gr19_v10_g1648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000032">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="172"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1648.t2"/>
        </source>
    </evidence>
    <sequence length="566" mass="64166" checksum="0C676A07306F490C" modified="2023-02-22" version="1">MIILYGSESGTGQDFAEQIWLELRNDNTKVSVKCMSFDDYQISNLCDETIAIFVVATSGQGEAPTNMRNNWRNLLSRKLGSEWLSNLNFSVLALGDSSYQKYNFAGKKLYRRLLQLGAASLMELALADEQHTLGVDEVFEKWLPELLSLVKNYSTEPKFGRKLPNYVAQIFGGICTVRFAPFEQIPSDIETRLITLSLGQFESALSYSPGDVLMVLPENLPKSVEIAVNALVHCKSLLEEPFHICRTDVDVPFRPQFARFFSSAPITLLDCLNFYFDLQSIPKRFFLRQLAKCSSDPLEKERLMELSSDMGIEDYLAYCHFPRRTIAELLRDFPKTSSCLKPTEMFEFFPVIRPRAFSIASSPQAHPGIIQILVAKVMYSVKKMAFPRFGLCSNFLCTRKIGDELRVRIRPGLFKYGKGGGPLLLIGPGTGVAPHRSIVAENESSVGPFAPITLFFGCRGAQRDFYFKDEWPNYARTNLIPAFSRDQKEKIYVQHKILEHSMEVCRFLEHDDCRIFIAGSAGDMPPAVVSALKEVMRKTRHLTESATDDYFEGMERSGRIVYETWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEC3</accession>
    <name>A0A914HEC3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C64 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HEC3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16730.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16730.t1"/>
        <property type="gene ID" value="Gr19_v10_g16730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22768">
        <property type="entry name" value="OTU_OTUD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF27">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="12">
        <location>
            <begin position="89"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16730.t1"/>
        </source>
    </evidence>
    <sequence length="666" mass="73913" checksum="881F2DECB7154275" modified="2023-02-22" version="1">MYIATSQSCNGISGEPSSSSPVNWRCGTLRGKQMAKAPAYAFILPNLEQYPADFRRFLERDIIEISTLRRLENSGHLNWWCQHDNNQRLWPLVTTGDGNCLLHAASLGIWGVHDRQLNLRNTLHDVLKFGSRRHAIYRRWRWHESKSNLQSELVLSEEEWRREWNAVLELASPTPRQNPSDNDGSLSTEETSSSQQQDQVYESLECVHVFALAHILQRPIIVVADTILRNAKGEELAPIPFGGIYLPLECPPEQCHRSPLLLCFDQSHFSALVAMRQSIATTLQVIPITDKNRNLLPVHFSVDPGPDFTWWRDSDDFRIAADIESIQSDDRRLELISRYMDIVRMDLRRGSVRKTVPMPFANGGGTFNGATPSVPNKLLTLAAGGSDFGAGRSAWPSSCLNAATVECTHRQSSGGITSRVGTSSILKEIRQHFRRLGRKSSRQSRCSLPMTTETDQHHQQQQHHNGHHSSSAAPFSSVELLQANHVLTVLLHNYAHQYIDSMLSLYIANARERFECAKLMPQSSLPKNRLSRSFSTASVLLTCLSTHCQRVAHPSNNFLCDACFEAQKRELTRTLIGDSGAAVAAAEAAASSCTTAAAPAHHSPASSVVAVAVIDGTAEAELLAPPLPPKKSIVQQHRHQPSYDSGLHPLMSPVTGEYCVNCQLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HER6</accession>
    <name>A0A914HER6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HER6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16466.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16466.t1"/>
        <property type="gene ID" value="Gr19_v10_g16466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="6">
        <location>
            <begin position="360"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16466.t1"/>
        </source>
    </evidence>
    <sequence length="629" mass="68616" checksum="6C311905F1A1CEDB" modified="2023-02-22" version="1">MTTSADERDIGGMDVPFVEEQLNEFNCAMAADDEVEEMVHKMNAISTTYAMDSVDFMDGLIAFMKNCKKTEVSMRILDDYEQQILLKLNNAKNAPKRAAPDLRKEREVLRELSFATDFAENVAMVDETVEDGAVEQHAEFEAAFDDDKNYTPQPKIRKTTTPNGAIVAVRVVGDGFGWPVKSSYTGAAFVGANANGGASTDSGRGRMLPTLRVISECNAGAYTHGYGNIFNDICAIVPCGVRPVVFEHAEDDAENQQHLSASTRSLIGTILPTDGNSLSFENALLFTESRTFQLDFEHVDNISIYPGMKISAKCLIDDTPGGLCRVQSVIEPSKLQMADLEEDDRQQQHMAMGQLSRLKVVIACGPFMSGGGTAANSDQFVELLNSVATANANVLILCGPFVPQAMALSTEAPEAIFANLLIEITKRLGMHSVRVLILPNAQSDLNSMPYFPTPPLIRPSKISLPNSVTFLPDPAVFEVHSVRFAVSSSEILMHLCRKEIYKSANVENEDRMRRLIAHLFRARSIYPLYPADPEFPLSLPNAHTKLHLAKRPHVMILPSLLQPVTKVVDDCVVINPGRFDRGKGVGTFSVLDLDLLASARASNGAAAADGGGTSIAQFCEVSLFSTQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEY8</accession>
    <name>A0A914HEY8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-oxoisovalerate dehydrogenase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Branched-chain alpha-keto acid dehydrogenase E1 component beta chain</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HEY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16526.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16526.t1"/>
        <property type="gene ID" value="Gr19_v10_g16526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000004">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="52"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16526.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41330" checksum="2A35372F01180190" modified="2023-02-22" version="1">MANRVRITFLDWTLRNCAASARTSSCRYSSHFTFYPTATIDNSNANRLTERVNLCQAINQAMHIAMEEDQNTICFGEDVAFGGVFRCSVGLQQKFGKSRVFNTPLCEQGIAGFGIGFAVMGQRAIAEIQFADYIFPAFDQIVNEAAKYRYRSGNQWACGGLTIRATWGAVGHGGLYHSQSPEAYFSHTPGLKIVVPRGPIQAKGLLLTCIEDPDPCIFFEPKILYRNAVDDVPTGKYLLPLGKADIVRQGTDVTLVGWGTQLHVLLETAELAQQRLDISCEVIDLQTILPWDVDTVANSVTKCGRLLVSHEAPITSGFAAEIAAAIQQRCFLSLEAPIARVCGWDTPFPHVYEPFYLPTKWRCLEAIRTLTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF14</accession>
    <name>A0A914HF14_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HF14"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16911.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16911.t1"/>
        <property type="gene ID" value="Gr19_v10_g16911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF6">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="66"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16911.t1"/>
        </source>
    </evidence>
    <sequence length="503" mass="57184" checksum="400608DD7E85D264" modified="2023-02-22" version="1">MNAPHLLPMENLSAAWDIINFTNDDYDGTLSTGNDSCDYKGTDYLEVKILLIGVFATGLALLSFLFNAFFSLVFALNARLRRSSLYYFGVLALLDLALAINYLALMSVPVYMDQYRLLWLYQLFLAYLRPMLCLSNFAVFASVLMILLATSERLLQTFSGRRVVKARRLLQRHRPRVTLLMMCWSFAYKLCTYFEIEVVENDNCTEFERFEVRSAVEGDEWHVYRFWWMFVFRNVIDHIGPFFLLIILNFFIIRALNREHFRATHSFATAAAAVPLRDNDDPRLRCTATAARDSLRRQKGCGGSGRLQRHALTLAEDNSQKQNLRAATRTLIAVVSMYLMSKVLQVAVTFFETFSTDEMIIAANYGPFRPLYSYVNDTIPILTLLSSTLRFPVYCACNKPILTASKATLRRLFGPEWPPSMSTANNNNCTKTSYCSSSCRSQSPPGKRRVHKFVLPAAVNGRRCNARVQSPRSRSVNSPAAARIAIRGIDEAELVAMMLNTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGS9</accession>
    <name>A0A914HGS9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGS9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17224.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17224.t1"/>
        <property type="gene ID" value="Gr19_v10_g17224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="172"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17224.t1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39633" checksum="65073048485244A3" modified="2023-02-22" version="1">MLQTTAGPMFYDSYGRVCRPNSPSQRSPSAEHPSRVPPQLDDVSLFSADQVACICQCLENCADFSGLTFFVERIEKYCGLLANHPARDILHRAKALSLFHCRQFGELYAFIQHSQFVPGDHSLLQRLWNEAHYAEVEHLRGKQLDPVSRYRIRKKNGFPRSIWDGEGTSYCFKKSARQILRETYRRHNMPSQEEKVRLARKTQLSVVQVSNWFKNQRQRARQHRLQQKNDQKIIICSSTESDGTEGEQQNIARRDGGEGRWDDPPAEVPLPGAKMPFLRCTPSSSHFHPSIGHLAVGVVNEAAMKWGRRGRRRNCRRAEEQKGEEEFGGRKEENAAREELKREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGY4</accession>
    <name>A0A914HGY4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGY4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1652.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1652.t1"/>
        <property type="gene ID" value="Gr19_v10_g1652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR DMSR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1652.t1"/>
        </source>
    </evidence>
    <sequence length="606" mass="66484" checksum="A7CE538E623B711B" modified="2023-02-22" version="1">MDPLHQCSTDVFQLPDQSPFYELLKTIKEFYQPIHTYLSIVLCAVGTLCNVCNIVVLTRKKMRSPVNLILCAMACCDTVVLSSNMVYTTHYTFVAFNNCVPKNWSYGWCVFLISHAHLSLVGHSSSIWLSVMLALIRYITLRRRGKSGGVQIGLQHSYIAIASVVVFVSLMNGPNFLTYKISEQTLDMTCGDLVAEQFKNDTAYVPGVADVALELFPCLLLTLLVSLLMRILREVRDNRQRLFLAGRGAAAAVTVEAQSSQQIQPDTSSNATAVFVFSTHLDQHERASHIQKQRHQRGSSPSPSALSSISVVSRQNRHSSNTNPPGAFPLPPTAHCPVAHSRLLTANCGNGRAPALTIATPSPVPTANSPVGAFLSNSGGTTSRRPKSGSGGGSRTDRTTRMLLAIVCVFLITELPQGVMAVLNGMFSEEFHYNIYNRVGDILDLLSLCNACTSFIIYCTMSAQFRNEFRRVFLPAYGRMKCWQRFVVRLDPNGRRRGKRRRRNEISEGKSLLERCANCKSSAQYDANLRRASPEALMEGSLTSTSIPPAAAARISPLMGLGHCSGGTSADDLLAEGLLLRTQRTDETSPEGSSTHLNLNTERLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH97</accession>
    <name>A0A914HH97_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HH97"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16605.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16605.t1"/>
        <property type="gene ID" value="Gr19_v10_g16605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="60"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16605.t1"/>
        </source>
    </evidence>
    <sequence length="547" mass="61315" checksum="8CF911B38287AE74" modified="2023-02-22" version="1">MIDYVSNEEDLGECRNERLFGKFGPKTSDGVPQPISGSVDEPSAPQPKLPDSVNEPSVLGGVLNIGNTCYMGAAIQTLANVSELSDFLLSNEQRFSHLPMVRKYAQMLRALLERKETATPQELKEAISATSTLFADNEQHDSQEFLQFFLDALHESLKKVPEAKRGVPSEEMSAEKRAIAGADDGTVHDGDGMWQNAHNQWKKEVLSAKEGSTVLDLFAGQFLSKLHCPNCAHSSNTFELFTMLQLQIPVPESIWILFKAIRSDINSTVVRYAMRIPSTTELVGIKQLICERIGIATGEGHIIIQNKSDRKYNADVSRMFNAKKDEAEPGCTLMGMSLHAIEIWCFEAENIAADYGNRFIEIYSESLFSDDPSLAEADRSDLLSIDACLKDFTSEEQIDGSHCDNCKSPSSKLAKQLSFTRLPDILVICFKRFIFVPSLGRFSKQGVPVSFPLDNFDPSPYFARDVPQQFLINSRYFCIGIVTHHGQLNYGHYCSYVRDLSSNKWIFCNDSKTLLMDSVPSTRDAYIVFYQRRADVRTSTVRRDPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ49</accession>
    <name>A0A914HJ49_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox protein cut-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g17110.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17110.t1"/>
        <property type="gene ID" value="Gr19_v10_g17110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="16">
        <location>
            <begin position="583"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="16">
        <location>
            <begin position="907"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="16">
        <location>
            <begin position="1120"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="1363"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="1365"/>
            <end position="1424"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="191"/>
            <end position="270"/>
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            <begin position="305"/>
            <end position="328"/>
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        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
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        <location>
            <begin position="746"/>
            <end position="778"/>
        </location>
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        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
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        <location>
            <begin position="1065"/>
            <end position="1124"/>
        </location>
    </feature>
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        <location>
            <begin position="1420"/>
            <end position="1440"/>
        </location>
    </feature>
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        <location>
            <begin position="1523"/>
            <end position="1574"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
            <begin position="491"/>
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        </location>
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            <begin position="764"/>
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            <begin position="1065"/>
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    </feature>
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        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
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        <location>
            <begin position="1526"/>
            <end position="1535"/>
        </location>
    </feature>
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        <location>
            <begin position="1536"/>
            <end position="1553"/>
        </location>
    </feature>
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        <location>
            <begin position="1559"/>
            <end position="1571"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17110.t1"/>
        </source>
    </evidence>
    <sequence length="1593" mass="169467" checksum="828DC412099012BB" modified="2023-02-22" version="1">MTATVLIALLRSHFIPQFERINGSTTFAMATEFGGVRDKQPDGVRTEDGTKAPEDGTNADQGTEREVIAIKQEIAELPINASRNGTNNIVAGGATDRKTTTAFAAASGGTANNANSLTVEKYLMHLRQKEERIRQLEEENRTLKCALLDKSRAYQAQVDELTSELVRNAEMVARLQSELALNKGASIITHSSTSSIRDISQKKPRKVPSPGQHPHNKQLRHLLHNGHASSSPSSVPRPPGRANAALQAQKNVTQPQASTSTTPQATTSSNDVDEICAALQHFVDRNRPNQQPNGGAVMEAIMGVLKGGPGEGTSSAQQPTQQTTEEEEQLLAAQLAKFVADDPCLLSGLLFGSDSSQQQLDPSSSSAAENDVNSLDPGLFALSMLFDEMAGNEGEQTQQHGTTTDGQQTTALDGIKKDQEQQNIDFEEVMQRVIGGTAAASARPGGANSAGNGAVQISTVAVPFVEPKGTGKMPKKKSCGKPKSAAGVGTPSMQSPERSSTGLPKTVPIIITDAIGAPIALPKVPTNSSGGRKSLSHIASGVSLLNGDLQHPNGTNHTPPTQKPWSPEELKLVKQLEARIDENIVSLGPAPLNTAELAAQCTRLMRGYSIGQRLFARTVMVQVSQSQGSLSELLSKPRPWHKLTDKGREAFRRIFGWISDDVAIDLLCQLSPRKVALTEKLEHPNPQMLIGGGDQMQQIDICGVAGPNQAPTEAGISMSNVKMEFGGVGSGVGRGGMGKRALKATNSFGNAPPSKRMAVKVEQPSPSEISPTAKLTSKENGGNVTVALSAGAGGGRWRHDDIPKEKIIDIYEAEKAKLMEQECHLERAIGLSSASPSISPPPGRTASTASVPSLGQIRKFHRAGSALSNGMGADDRCLSSVCSPLSATGADQQLIGRYGSRSSDLPPVQFERYPILDTEEVVRQIKECLNDEQISQRQFGETVLGLSQGSVSDLLARPKAWNSLTNKGREPFIRMQMFLEDKRVRKLMRTDSDGEAVEFWRPDSQPDTGAESGGELDLRLELQTDPSSCPTSVPATDGDDEMAADIDGIGDVQEEVKTEGVEDVRIGAEDERIAVPEEGKSDGPIAEGEVEDGDGASVKDKSKDTTPKVFPPQGKTKTQQQNYATADEVDTADVARRVKAVLAGNGISQRAFGEHILKTTSGCVSDLLTKPKPWVMLGYKGREANNKMVAFLDDPEAVNRLKAVEQQRCAMNNALNALKAIGDSEQTLGGQPQQSNGHMNALEALGISIPIAAASPCPSASSPPPLQLSQPSTTSSALQLIAGLASVASDLSSNVPIGALLKKNNSPNPPATSASAGAMNAYPNALKRKAPCAGVGSSVSMVSMDRNDGSSAAQIGPLVPAKKIPRFQRTIITDKQKEALLFIFAHEQRPNSRCIEQLALKLALTPRTVTNWFHNYRTRQKAKETKPDGDESSVLPTTVPANVPTPAQILARALNASDSKTTSWFRELAELLRMHSDVSVDIDSIGGSRGSVGTASVASSPPSPSIGPTTVVAIQLMSDDGQIDTTTEEGEEEETRGEAYDAERQDVTAREADSPALHNFSNNQPPTSAGSQLDKAVARMRSRLMTGLASQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJF3</accession>
    <name>A0A914HJF3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJF3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2025.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2025.t1"/>
        <property type="gene ID" value="Gr19_v10_g2025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21983">
        <property type="entry name" value="HMG-box_SMARCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46232">
        <property type="entry name" value="SMARCE1 REGULATOR OF CHROMATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46232:SF1">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2025.t1"/>
        </source>
    </evidence>
    <sequence length="406" mass="47095" checksum="47E682575BE94072" modified="2023-02-22" version="1">MYRPTSSHRSSQQDAMRPPKIPDRPLVPYMRFSKKMWPKVRAEKPDVPLWELGKLIGQLWNGTPPAEKSVFTQEYEQEKIEYEKAMKQYNVAYAQYMAAKNRVKSAHQQHQEKGGGSGRKAASEAVTGVFMQPIDEEDPFELAGKRLAAIRYGKNNRLMAELFSPAYLPDPRSFVPQQRIDHFRRQRMSLEQHQVKSNDELARMDELFSQRKRAIQRDSEAYQGTLKKVCEERPRVDQQRCDELTEQYKEQLLNAWDQFQTKQAAIQAKLEADRRANPVLAELITSKSPAQEEGEEKESVEGVKKEETQQEQMEDEGKEVLKTEEKEREEEEEEAAEVEEEEEALDGKEVKEDEQKEEQEDVEEGREEERHETMPNTEEEEAAANGTANDGQDGEKQQNGREEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJY0</accession>
    <name>A0A914HJY0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJY0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17565.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17565.t2"/>
        <property type="gene ID" value="Gr19_v10_g17565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14699">
        <property type="entry name" value="bZIP_Fos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17565.t2"/>
        </source>
    </evidence>
    <sequence length="563" mass="61345" checksum="ABF7313FD042D192" modified="2023-02-22" version="1">MDAPPPPPPTAELSICWARRRHGPARSSRPDLPPSQPTTAASATIMRGTDGFMNRQAIQTAFRLVQPSPPPVDGAHPLVMAPLMAAAFRRPAVVHHPSPLVPTAPALYPNVYAAEQPTPSAFFPTPGVTPTYGGCLSLDPIGMAFAWNFFGTSDVIGYELNTSSSSDSPSTENPQLLHSLYPSTPSAPPPSVQQLSSLVAAPSSQSFDIENPNFGAAANSPQTSDSPSTSKPTSTLALAMPRGANSTKAAQRRGGRRPREAEQHEQQLTDEDKDRRAKRRERNKQAAARCRRRREEKMQSLQEQVDELRKQNERRESEIRKMREKEHRLLEMLRLRSGGIVQQQLHHHLQAVHVQQQQQQHPSADHLAQASRPAALLQPFLMGMNNRRRVSFDAPMPSSSSSAASSSKKEESDVNSSTDESPDGAHHFPLGVISVSALSQQSQPVSFELSTSVAASKRPKFEPFDMSNNRPTSLQLNSLYREGFVAGTPSKELAQFGVNGTEVELTPVNELTPGLSQLTQLAEHPTFGVLMAQETGLTPCQHGPVLIQHGGERPANGELNELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKI3</accession>
    <name>A0A914HKI3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HKI3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g217.t1">
        <property type="protein sequence ID" value="Gr19_v10_g217.t1"/>
        <property type="gene ID" value="Gr19_v10_g217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="107"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g217.t1"/>
        </source>
    </evidence>
    <sequence length="567" mass="64220" checksum="B57FEAC05BD89D01" modified="2023-02-22" version="1">MSTIFINLNKRRISARREESIEKIEHPSNKNHKMGKEKQQKHQNKVAQQQQQRSAAEEATAKKQCKLGLDVAKAENYSEWYSQLIVKAEMIEYYDVSGCYVIRPWAYSVWEHIQSFFDSEIKKLGVKNCYFPMFVSEAALEREKTHVADFAPEVAWVTKAGNADLANPIAIRPTSETVMYPSFAKWCKSHRDLPLKLNQWCNVVRWEFKHPTPFLRTREFLWQEGHTAYATKEEAETEVFDILNLYARVYTDLLAIPVVKGRKSEKEKFAGADFTTSVEAYVPVNGRGIQGATSHHLGQNFSKMFDIAYASETKGQAEFVYQNSWGLSTRSIGAMVMIHGDDNGLVLPPRVADIQVIVIPVGITVKTTEADRNELENKVEVIVKTLKEAHGVRAVADVRNNVSPGWKFNHWEIKGVPIRLELGPKDLAKQQAIAVIRHSGQKLPMPLADLGNDIKRTLDTIHDEMYKKVEQIRDENMVVCLDWDDLAPQLAKKRVVLSPFCGLPKCETAIKDATVREEAADLGVSLMGAKTLCIPLEQPKDVELPEKCINPNCSHAAQFFALFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL04</accession>
    <name>A0A914HL04_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL04"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2464.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2464.t1"/>
        <property type="gene ID" value="Gr19_v10_g2464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037966659" evidence="1">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2464.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25444" checksum="628C9F2E4AC02AC5" modified="2023-02-22" version="1">MILLILAASLAILHGGQAVQNQTTLCTCAQAAKCAEDGFKQVENACKSECAHWLSTFVPQNGKEDAHALAPCFVRNVKMEALPMNDCMRKRVDNYCTSSLTAHIKVPAPDYAGWMESISAGNSTAFDQKHKSAFLRKSRAAFITFRNFQKCMNNCAKKRSIQCFDAEGCAITLPSDRAKAQLFYNQCTQQQNVQKNARDACNCLIVKHKVRQLVGVCPLFLNKQLMQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLI5</accession>
    <name>A0A914HLI5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLI5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2451.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2451.t1"/>
        <property type="gene ID" value="Gr19_v10_g2451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2451.t1"/>
        </source>
    </evidence>
    <sequence length="718" mass="77239" checksum="58DB243F46A9C94F" modified="2023-02-22" version="1">MFGCCLSIQVTIKIAGIWAALLSVNGLTCKRAHKAEWANETESWDSLCPYRKGIDERCYVLNCSDGHNVRSEWGCVSEFDDGNLGNCKSGPNFFEDNGLSCACQIGEKDKDMSNDGMAIPLTTTTTTTTITTTTAPPHFCIQAKIESPESTGNETLSEKQCKPEEAFCFFYNCTSGTDPNKRIAEWGCSKDDYSSEICTQKLDAFGYKLKNVDNEDLCKCFIGWSNKEPYSMAQIGLNELPRDDKSFSSASRSIGKFEAIFMTCQIVIAIANAITWRSSFLSPSKGIMSNQMPSENQQQQQAPTQSPANFDQPFVQRSENQQQQVQAPTHVHAGSAANFNQIVVQRSQQQQQIQAPMVHPFLPQHNAGGVVHQWGQSGGVQPPFLPQHNAGGVVPQWGQSGGVQPPFLPQHNCRNWPASRHSRHLLDHYHNQLYLHRNDNPLCFVSKIRPRTKNNPSIPLIHHFYCLRFLGNKLLSLIGVNSGTVSSNEPVHFSRECPQAGGGGEGVNSGTVSSNEPVHFSRECPQAGGGGECVNSGTVSSNEPVHFSRECPQAGGGGECVNSGTVSSNEPVHFSRECPQAGGGGECVNSGTVSSNEPVHFSRECPQAGSGGECVNSGTVSSNEPVHFSRECPQAGGGGECVNSGTVSSNEPVHFSRECPQAGGGGECVNSGTVSSNEPVHFSRECPQAGGGGEGVIDDGGDSEDCDIELQQSGPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLJ4</accession>
    <name>A0A914HLJ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLJ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1897.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1897.t1"/>
        <property type="gene ID" value="Gr19_v10_g1897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1897.t1"/>
        </source>
    </evidence>
    <sequence length="344" mass="40560" checksum="97B4A868F7DEE266" modified="2023-02-22" version="1">MSDNPTKVEKRMKEIFVCDDVLFEVFEFCGHFVLGQKVALISDRFDRLADAHFKSMELSLGRLLIRRAKDGNGAQIVKRRLGKHRKRRLPIPQEPLPANVIGFESLTISYIDRSVIEFLQRIRRLFDSNGANVHIKTFINQSRSWQIIWHQIWPLINANICCLVLFLSTFNCLRRFSPTFLRDCAKLRLVKFYGPFPVFSTGDDNAMAEWLHTPRGDGLPKLFECDYRPERLEGLKMTFFNSTNPVNFIIRLWHCCSVDIVPFELRNNLTGERLVLRYFKDDNWLLVRCPIERDEDEWAKWEQEEAVRNLCRWNRIDIDFTDTDIGDDLFDANEGPIEPKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMA1</accession>
    <name>A0A914HMA1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g2798.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2798.t2"/>
        <property type="gene ID" value="Gr19_v10_g2798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="576"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1534"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2365"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1665"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1844"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2518"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1670"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1853"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2519"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2549"/>
            <end position="2559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2798.t2"/>
        </source>
    </evidence>
    <sequence length="2559" mass="291404" checksum="6FC50AAA8D497E4B" modified="2023-02-22" version="1">MSFCQVPTDFVVDLPMEVPPSFYPPPTVWVPQIDIPPLRKYEYRFEREKTAIFRWEKERLERNKEAGKAQNKLRQRQTEDEKGTENGRTEWRHSSESWEGGSESPNGPDDPSEECRKERGFLSDVRSSPNAPKPNLPPHFAPSPLLRPVPMSTSSASTSHIGTSSDQNGIPIQKSHSTNNTLDGLEEFEPRRDLFDILELRSLDARRELEKFFNFFDSSTMDGLTLAELFQFTSLNAQNEFSLRTVCALLERRKTVESYDADEAAASHEVQPVPPSSSTEEWFLRFATILRPSLRSPFGFVRLRSLQLLLQLWPFGGRATNSGSESLENAKMLANPIGMLIEAEQCEVSFHSYRQRAQFFRRLKRNNLLALLPSEDEAFRELMEKLVLDVLLAQLYERLTLYWPLLTESIESYAQSLDLFWDCFGFALDFAWDALSEEQNGRNEDEVDKTVGCNTAVNFGSFRVQLLRLLGKLPSARSELRTRYLSPKLITLYRDEFMQFDEPFPTTSSKPVKGKMDSEAQQLCEENGGEEERENDFVDTDDDNLEPSKKDFCPKIGKESAAVKPLRFRVGRRNAVQAIKALLAVYGRFSNPRGVFREREIHEIYYELLLVNEAEVQRAALGCLLTYKYAWLTPYKTHLEALLDPRQLRDHLVLFVVDNRRDADDLLDEHSLTDQHRPELIPVLIRLLYGSLYTHVATRGKTKRLAIFRFLANCHSDELGLFLQLIFGPLFSFFETNDENDAISGLERAFSSLDSKMDVVRSMSLNKLKSSLGSLSDVFHFLGPFLSDAQLALLFASIVLIARILLQHSSQRFRQKENQMDGDGTASMERFLKSLRKVLFLTLIKFFRAFQSRPNLPISAFHSLFQQFLGPLISDFNEGRVFTSKCLSLPVSAIRLFCTWGQINRYFPLLNVPLSIDFADSDSICHSIVTTPMALLCDQLFLLRSSATKSTIQMDILRVVCSMLDSHDENTLESAKIAESSAADLITVLPQVPLEMPEMNAIPAAFGVSLVLSNGQLDKILGYMSNFVNIAGGQLGSKVADQMSRIPTIYFDLLSRLSSHIQRPELASMFAHTLLRFVTSKNGLMLKRRPDRAVVVLATLGRLAPHLEDPLDAVARLSPLFSHLEGRQLRWALTQMAFSIRENPCLPSGAKNLIDLLEALESWDLRRIEDPDADRRCEALLRLHDWYEQRNRHVLLEDGAAHTLPLLAHSHVHSMLQNSDISLRGTAANTFRQLIQFVADPPTAAKGNFDVVRMLRSHFIPLILRGLRASVEDESARHEFIQCLASLARCFPNEPQLTSFRLIIGSMAPASAEFVVDPDIDFFECAMHIQLHRRQRAFHRLAERLNSGELSVGHSLLLRFIVPIVQPYLMDTAPNRSALSDQALHLFSSILRRTPWPKYCQMLDHFLRQLDTVEEMRTKGAIRVVSAVLNAFHFDLRHLQINDQKKRGEYNGGREVGNDEGNVEGMEEDDEEVVERDEQQKESDQRESDGIGKSDEEEKRRIFGVVKGRLLPRLRECLHNWSGANKPGSNWDLEEQKLLRAPLTLAVVKLLEWLPPHVAEQHLHGLVLFLKHLLMSRSASTRQNARKLLEQMVCLLGPAKLPFVLREVKQALNKGYQMHVMVVTVHALIGALEGHLASGDMEPVLREVVDVCRWETFGSNNDKYGTAGGDVDRRSDSHGVPEARASGKRTGHTLTIVGRFVAKLDLLEQYVFAVMRDIANTNSRSETVRKLADWLRALNVGLRINAAIGSREQLRWALRLFDENLRLMSADERRLSQMNGESSTAVGRRPANCLLLPPEPKRLGVIQRVAVKSKVHIFVEFALQILVDQLAKLRHLLPNSGEVGGNCDDEEEHDNRDKCEEENKKNDKIFEDKLKASDLQQIVPLLEQFVPLIIEALKQKYDKVIALSLRALLHLFKCPQLFLANERIEKLVDLFFVLLADYSSVGSAEHRSNVLELQQQLFKCFTQVIRNISPTLLNGDRLQLLFNYVETDILDVHKQTTAFNLVKAIIGRKIEDKSLTNIVTYLSELAITSPSANIRSQCRQTVLLYLTVHPRGQRQYERWMDFFLNQCEYELEEGRLSALEMVHSIISEFTEEANARYALLVHLKLCVRLLNDDSVRCRQFVALALRRLLCSVTPSAFNDCLAATNDWLAAKKPQIRLLAWRAFSQFIASECQHFGPTQLRQIVRRACHSFSISTKLFVDQSDTTKLALSQKVDQILVKSRHSSKCRRTSVNFDEEISSTNRRQKTTIWPQFFVNLDHCLGRCQRNALNLPLSFAAGAFVAKLTEFTECREEIVKHLSGQGAEDLPLDYSPLCSLCLNLITQIDPKPPGKIVRSKVNVGEAVVEETEEDGENVRQNGGGRWDNELAEQAVRSLATLMPSLSGAHFELTCKKLSKLCWAEAVTESDSARKRLTIFKLIGALAVNIPSVISEQFSHLCSYFISIIYREMSKKSSKYTEELHSLAVEVGGELRRRIGDREFTSRLAKCQRERTERVQRRKSDAKTLFVTNPVAALVDKQRRHERKKEARRRRLDIRKPYRALKRRRKTANGNTNERNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN19</accession>
    <name>A0A914HN19_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914HN19"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2670.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2670.t1"/>
        <property type="gene ID" value="Gr19_v10_g2670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2670.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31107" checksum="8827FA38E5BAD568" modified="2023-02-22" version="1">MVNWLAIRQCQKRFDHAKYGIMPKHGFFSQHLTVQPDIREFTSHGIVWADGTATDGIDNVVMATGYLFNFDLVENGQLIPAKDNTARLYKNMLTPQLADWNTLVIVGLAQPSGAIHPVAEMQARLFFAALCGDAKLPSREGMERDIDRSQAELAKKFVKSTRHTIEVDYILFMDELAELLGCKPNPLDFMLSNPRLAHALLFGPNAAYVYRLCGTKVWDGAEQAILDIPRRMDVCLSGRKVKKEVTTPEWAEYRTLVAMFVGVMVVVVYLLRAFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP05</accession>
    <name>A0A914HP05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2361.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2361.t1"/>
        <property type="gene ID" value="Gr19_v10_g2361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2361.t1"/>
        </source>
    </evidence>
    <sequence length="498" mass="58557" checksum="1FBC6FC235D3B5AB" modified="2023-02-22" version="1">MSISTESINGEITADTDVLWLTCANLDPSEEFGKKVVDADTLGNRNKIEEMELELKEVKEELKDIKKELKGMKELEEELKQYKEESKNTNELFGKRLEQMEEWKRITKLELENKELRAELAHQKQLNACKCMTVEEVLDMHKLKQQQNQKEKINFVLGRRAKTDELERKQKADQIEHRAKIDEMEAKVTLEHQKLVEDHKALHTNKEEYQNKQQQNQEENEKLKNLMEEMKLKQQQHQKEINDKIGWLNKDQEQCVSIDQFSRVETAISDLEQKQKNDQEELLRKMDESLKSVQSMVISELKQQNLELQSDQKALLQRLNALEQKQTAYAEQQNQFNERDEKLNNILGQFIEEQNKNHKKMDELGNNSKKELEKGMNQLKGELSAKMEQYQKQQQLNIHVKLEQYQNKQQQTIIDLQQTIAVLNDKINGKDADAPNNSTTNHVRIESTHASNNSTTNQFVGIQQQAPNANEHHQLRRLLMRRKYVPPPRDAYVSPWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQR9</accession>
    <name>A0A914HQR9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQR9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3030.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3030.t1"/>
        <property type="gene ID" value="Gr19_v10_g3030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="168"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3030.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="41573" checksum="59FE7EC3D0FDD751" modified="2023-02-22" version="1">MPRVCCCCPTESTPIALAASENCTKNGGFEFFNRWDSTACHERLALFEPGRLIVQHNGMEKECWDSTACHERLALFEPGRLIVQHNGMEKVGGSVRAEKPMQENPYFEVKILEKSYIHIGLATKQMPLDIHVGRYKQCFPGSGSGAGSNASTSTPERQQKRKFAEGPPFSDFFKARLCPSNVVTEQEQNLARLVARPTTPISIVESDEFIKFVENYDSRFKIPRSSHGIERLLKDKATAVFIQMKELIANALSKISIGLDKKWNRENTGYKGTYAYGNWGILWGHEVDGCYHSFNGRPFIEGKPPFGVGDVVGCGVNLKNGQIIYTKNGEHLDTANLFVNSAADLFPCVSLFGPGTKIEAIFGPNFQFNISEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQY0</accession>
    <name>A0A914HQY0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQY0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3085.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3085.t1"/>
        <property type="gene ID" value="Gr19_v10_g3085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="30"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3085.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25978" checksum="C739391D06A03289" modified="2023-02-22" version="1">MQIQRRRRLPLELQCEVISALPFQHGRRMLLLCIPIAINCIALVRKQKKNRWDPTVCHDRLVLIGPNRLIAQRIGEANLGWGSVRAEKPMSKNPYFEVKILEKPIGRIFIGLATKRMPLNKPVGVYKGTYGYSNWGLFWGHEVDGCSHNANGRRPFIGGKPSFGVGDVIGCGLNLATRQIIYTKNGRRLDTAGFLVDSAVDLFPSVSLRKPGDKIEANFGPNFQWNISEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRF7</accession>
    <name>A0A914HRF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3553.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3553.t1"/>
        <property type="gene ID" value="Gr19_v10_g3553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3553.t1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50210" checksum="DC41A4EEEE5EB65B" modified="2023-02-22" version="1">MIDHPVTSGGWLAACFHTFPDHCFLCVCVSVHIISVPVCGLGIDEECAGTSCRRRRHTVARTTAFQSTTFSRITFFVFSTSHTTDQFFGFICCVLEAPRHTMKFVALFVTAASLLVILCVVCTARRAPMRLLEPNKYLIKRNFVTGSYHYKNLSRITEPQPVRRLRLMVTLSEAAGSAGFIEVFRVKVRWVGPELWWDNLQSVENGRYCELRCELEDENERLPHTFLKLNVEASINGYDENFLVRQPFPLLLRCRMRSVNGAGLFSRWIWTNTVKLYKLGYYRHKNYMGEQQRQAVTAAAAAAHWQDGRQLWRKPPMPVATYLGSDDNPSDESNEEAPQEEEALPAGRFSMVDSPRRAEAHRVRFPQHVAYHQPAAESSSFEFATSPTPSPLPTPTQGREQQQLRVPHWELLNRRNKGGTIETEKSPAPPFFLRPPIEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRH2</accession>
    <name>A0A914HRH2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g3565.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3565.t1"/>
        <property type="gene ID" value="Gr19_v10_g3565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ domain-like"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="773"/>
            <end position="868"/>
        </location>
    </feature>
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        <location>
            <begin position="990"/>
            <end position="1082"/>
        </location>
    </feature>
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        <location>
            <begin position="1089"/>
            <end position="1173"/>
        </location>
    </feature>
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        <location>
            <begin position="484"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="870"/>
            <end position="956"/>
        </location>
    </feature>
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        <location>
            <begin position="1336"/>
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        </location>
    </feature>
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        <location>
            <begin position="1442"/>
            <end position="1468"/>
        </location>
    </feature>
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        <location>
            <begin position="1566"/>
            <end position="1590"/>
        </location>
    </feature>
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        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
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            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
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        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
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        <location>
            <begin position="627"/>
            <end position="641"/>
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            <begin position="711"/>
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            <begin position="872"/>
            <end position="900"/>
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        <location>
            <begin position="921"/>
            <end position="951"/>
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        <location>
            <begin position="1372"/>
            <end position="1381"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3565.t1"/>
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    </evidence>
    <sequence length="1590" mass="172634" checksum="64B9CF514C3FEBE1" modified="2023-02-22" version="1">MRPLRAQLDIGNHLLLNCSIIHSTSSQLQTKMPSFMCMPFLACNRQVDSLDRRQCNLQSIPGDIERYARSLEELLLDMNHIHDLPKSLFRLQKLQRLGLSDNDIHRLPSEVAALQNLMELNLSRNDISDLPEDLKICHNLQVLDISSNPIARLPDSITLCTSLTQLALNDISLTKLPHDLGRLAALKTLEARENHLRALPPSVAELSQLQRLDLGQNELDELPAEVGALRALVELYVDENSLERLPDAMLRCTRLEQLDASSNKLFQLPDELGELVALVDITVSHNCLRELPSSLGRLKQLMILKADDNTIDILTPAIGGCTGLTELYLQQNLIAELPSSIGNLKALQTLNLDRCQLRRLPALLGECASLTVLSVRDNQLHELPMEVGKLARLRVMDVCNNRLAHLPYTINVLQDLQALWLSENQSQALLRLQQDIDPRSGIKVLTCYLLPQRDASVAAASNDGVPSGTNLVANQQSKAAFVGGPKVHFGGDGEEGANDGTTAAEDGAEMGATFEFKRKNTPHPKNTTSGQGTKLKQYQQQQHKHKGDKVDGHVAPRVEEHPPSIVLSGKKVSHDHSSSLLAPAEQQPSTSGSTADQLRSALKYSSRAIQQQQQQHQTEAAHPPPTAQQRYPPSGSTSQPKTVLFTGAKPAPQTNQAECKLKRVNTPHYKSTRGTTGDGSSGSGSTRTSAPAVTAAQNQFQPAGGISSRRQLPQASSSLPAAAATVAQDGMHVQMEHHQRMQQHHNPSNNNNTDAVKVQLLAATALNAVERMRVNVRRAGADGDGGGGGGLGLSIAGGIESTPFVEDDPGLFISKLAPGGAAERAGICVGDKVLDINGTPMVGQRHHVAVQCIQQSSDVVELLLERRRTTTEHPPFSSSSSAFTAPAPPLAVSSASSSSLHQTVRFSPPAPQHHRPQLGLSSSASANIASHHASASSTTTSPSMTTTTIHHPNTLFPSALTTPAVLQQQQLPSVSEHPFGDPQLDDIVEEVELVRDSRNSLGLSIVGGIDHCSHPFGTPALPGVFISRIAPNSSAHVTRRLRVGDRILKVCSRDISGARHNDAVEALKNTGRTLSITVRHERQPTGLRVVVVPRRDTQPLGLSICGGIGSAPMNPQDRTDEGIFIERVEHDGPAEQCVGNGKPLTVGTRILEVNDESLLGCAKEEAAHIFRTTQPGPRPHRPYRLGRPPQCCCHPETFVQSRNSSCLLRQMPMLTQHIHLLQITTVTKPATTHSSAIDNEKMEQQQHQKKNNKKEQIGNEYQNLSAGHNGRYAVGLIPKNDAKTLVGREMSASVALLDIGTMEEQQQKKMEVTTFSSEPYHNNQQLNKNNNSICEQQQKKVAAPPPPVAPKPKTNFKSFAVTGGSKQQQHNVHGEGTDEKSNGTAPEASADFSSRLRLFQHEPSQNQTSSATLLPWAAPSMKLKRPLLSSDDLAKLAEDDRMRTKAALQPPVENGRRAGSDDTGEEPSQQIGMMLSPMSPFVDGGAFEHILNDSPVPFVPSSIGSIRTKKAENRFLQTNAALVLSSSPSPTISQVVLEQQRRQEWRQARMASLEAESRRVNQLITDVNETIGQQPSARPTTTSTEKSSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS41</accession>
    <name>A0A914HS41_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS41"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3231.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3231.t1"/>
        <property type="gene ID" value="Gr19_v10_g3231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037686634" evidence="1">
        <location>
            <begin position="24"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3231.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32569" checksum="CE1C7EB083419A1E" modified="2023-02-22" version="1">MEEFWILILFLFFATNSLDKANSVKVKLEETPIKPFEEIFGEGWWDKGEAEDLKMPPTNFGQNVHHQIDRQNTQIGQIEPNSTDQLGQLNAIQLISLDKLNPIQLISLDKLNPIQLIRILLSQSLITLIMPKMGKKIMLKTSENVKSSTNSTRKVFYEKEERKHLVEQFDQMKAELKRAGFKNSYQNELDKTVAKEFGLSDRTIQKWKRKLGQTKPIHKHSDSEQMELMKRYYAIKDQTSKISDEEIAKSNFIQILSMDILWKRILSNIQENENINSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTF9</accession>
    <name>A0A914HTF9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
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        <property type="protein sequence ID" value="Gr19_v10_g381.t5"/>
        <property type="gene ID" value="Gr19_v10_g381"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="415"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="822"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1344"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1399"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1475"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1594"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1743"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1974"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2088"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2294"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2323"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2478"/>
            <end position="2532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2196"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2393"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="871"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="921"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1151"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1242"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1345"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1399"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1499"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1512"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1614"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1743"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1974"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="2009"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2024"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2037"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2053"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2331"/>
            <end position="2340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2348"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2478"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2513"/>
            <end position="2532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g381.t5"/>
        </source>
    </evidence>
    <sequence length="3063" mass="335658" checksum="25886D7D21298382" modified="2023-02-22" version="1">MYTEILELVNFFARFFHLRIPRLKIGMFCEHFANNCFLRFHLYWNLNQPKQYEELRIIRVSHQYTDELFTSAASAVGLQLDELLSCIPERLIIVYVNPGEVFYCPGDYSPPVAVWVGPVCEDLKYNETCHVTFPPPPIPSSILPTHAIQPLIPRPTSNLPGAGCVNVTVDFSVLSWRIPLGLVHPRELGYATNPTSDFLMFRYCVPGTPNYTVETFASTRFGSYRKRPDYEFFTRLQHSLLLLNAQSSSDDIGRTFPLATFYRLVFFPLSPWALCPSLGFFPFGAREFLLLNISDRLIFDAKWVSSELGSKRRYNGLLEAEHHSEGSCQGFSMARRCDTTDRHLPQMSHLIFFLRPIYQLEHFRNVLAVLLGNKSKRTICNSEFKAAKAGMKEEALTGRRQHRDVQKHKFPGSNSELIPVYTKWANDLLQAADLPPLTDLSGELCMPLKLIVLIHSITFEFQKVPKEQLIALLSHNDALISIKQSLAYLCQIGVPLIDSIQAKDIRNGHLGAILQLLYQLSLYHCACQQQLHRQRPEEAPQQKQWPNRSIRPSSAGRTCYTTASSSTITPTNTRTNNNLPAEEKNQWENRTVETSASRKVAFKMPPDASLTSLEGANREGTERKGEEQEMASNVRLSRIASTHRSALRPPQISAAVSSKRSVARPQPIELLEAPKALGTNSSRLVPPSSQRSSSQSANTSPKGLLRGGGTDIIIDFVPPALPASKQLPPAAGFQTTNRICLPIPTVLTPEKKHSLCPEVTNRNSGRNSNGGLSDESKRTAPEGPNFVEASIVCNSSSQHDSSVSPTVHQQLQFQKSVLRQPTPSALAGRSKSALRVPISSIRSVNPTSDELNEHSPKQTGQSLPQHHHHSSSSSTSVPVLVSSSSSLPTSASSSLRTSQLRPPIVSKPVPPKRHTSTVIRSSEERLKEEPREGEATEMNRLRLFGGKDRERERKREKVSAPICIGPPSTEQHEAHQMPSYPPRGKDLPDQNGEINKLRKPTSTSKSLLMPPSSTVSRRVTATAGGGVQPTSGRAASQQLRSGETAKRGAGGRAGGGGGTTASQQMNTSQCSTSSNGGRKSGQLKKYSQTPPSLMTTSSSSSSVGIRITSKPASSNSKLTGIPSAKKTKEELSGNKTDSMTKEEETMRTEQQKCQAANSPPTTEKKPILAVKGISVPSGGTPSPAQKRPSLCGGRPSSADSASECPRSPLMSDSRRNPHMVVGVVSPMMHQQEEVLGGTSEANRSEERSVVDQQREKDNPSECEPSAIQKPPEEPIVVNSEMEKWNFPEQMLGLSDGSPPIHPEKVAKISKLAKAVPAKRLIIPTMASQILPEGTMEEQNIGGRKVPSEKCRGEECPSPSVPPSMAPTKLMSVLREEQASPCPSSSLSTPAEEETNRCYHFDKDHPNHRCQDGHSSQQHQKVSPDELISAAVATASDNSTDSVRTTIQIHCFSTKNDQLGELLGDCAIIGGGTAPATAEDNDGQQNLHKNGKGGIMGQKMDGEEGEGRRKMIDSNNGKQQLATEGAGKDAVGVISGGATSRNQHHYPDNPPMSGTADYASESELDFRRQPMARHLYSTSIPAGNKLVMALDLRPNSGTALRGGGRKSRFRESYEDSSSLSSGLSEPFDDDISTDDLTGSSSDYLLGQLSPNKMRQFAHENGQKHIDFVSFQKPNGPQPNSMVSAAERERQTAGQLLQKCKSAQRGCAYFGSAGGGGPIVDPHRPSTSNGYLPTPAVGHFVHNSAEGRRSGCDQHHRIEQSQHPQKPYQHHPNEQLFALREQGQQHRRQQQQQPEQQNQQQFDLFRPYHTITAVDWPPLQYQQQQQLSRTHRPVDARRLLSPPHNLMVLSDDGDTLSVAAGDVGERTTRGQSARPPGATLLGTQQQTMAATHLQNADLLHRRQHHQQHPAYHTHSLDRHAHLRVLSAGVRPLPAAADDHSPRQGQFANISRNLPHQRLQLNSLLISPRHHYSVNGYTSSTFAPPGNTNATSSSVHRRSRGGDLYGYSNGPLLPPQCFPPPPPPGSSARSSVASGTPHQRSASLSAMSRSMVTVLEQHEERQRRRGRGDGGETQRRVLEYVRGQLEALNSNARGDVIEAPPADKSAKSSHPPLPIPPQQRSSPHLNRRTPLSLPRQLELNNNHLHSAGSLSARGTDGRIYSNLKFPNSGVNSPTRLPIQQPGSQLSLASSIGSTYSTIEERYEWEIGKLQNELESYRTHVQLLSQKNSGFNCVIQMFDNRLQSIMLALGKLQQKQNVKRDEVERLCNEIEQLRALSVTAGVVPFSNMEGAACTLKSAGAKGDEQQQNGGGSNKKSWIRSSFNRAFHKGTKKSKQQQQQLQPLKDTTDNTHSSFPSSFLNLANNNNSSSSSMTSKMDSTKRELETRELALTDVQLDALDKAKEIDILRETVNRLQHENKLLKYNFSLLERRVHSESRASSHLSLNTTCMAGPGLDFDAATLEEVLVEAPEQLAALYDLAASSPSSGDISVNTTTTGSSANGAQQFVPAELANKSTDRSSFASSTTSSKRSSRGPSTALPSAKVVLCVDLSGRLDSPHPLGHLMSLPPSNSLCSISRANSGSSSTLSSQASSSLGSVMSGAAMTSKTGGTARRELTVGYLPLPVGSATSWKDLDQKLGLLLEEYLHRIDPDLSLGIDSYSSIIGYQIHPTQQQSDTGGHSEIFLIRRRGSVSETGQQQQLVENCAELGELLPKLSPAEALQPGTLIRIRLKGVVQHSVDALVLESLFPRHLLEQLLYQLEQHRRLLLFGPTGIGKSNLARLLAKYLLMRLERNNNNNPNTSKALVDIRFPMDGEKHRQEGNQQQKVKEQLIAALRPASNTAVLVMDNLQWKRLGTVLEAFNNSAAGEELLAGASVAADLPLSSPFVICTLNRTCVDHSPVQQLQLHHNFRLFALSYKMDAVNGYLGRYLRRRLAEQELSSYASLGPPALCPSPADPLESVLHFLGRSLRAVNEFIERAATGGPDLTLGPRVLLQCPLSSEEAQGWFVQLWNDKLVPYMRKVLTESKAFPIPAVDGDDKVSAFAKDPTDEIGTLWPWTGGKEQLLKICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTM3</accession>
    <name>A0A914HTM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tyr recombinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3654.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3654.t1"/>
        <property type="gene ID" value="Gr19_v10_g3654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3654.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32554" checksum="5F62729C7827855A" modified="2023-02-22" version="1">MGNWISTVLFPLRAFMHGFFVGRKSRALLSPQDVLFPPISYVLAMNGRPDLLDQLNFYLERKNVNAILHAGRVLHELGLANIKEAFINGVEEKLICRRCDRQIKFIDSLCYCAASAEKCHCTGYIIFHLLVDNGQRSELAYKLRRNEFLAVRHVGERNLKMTPLLDTKNDADDVWIGWSDKLYFLTNLLRDYIQKQSAVPAQALSNELDFVFRKPQGIHEPVCRKHMNEALRNFISRFKDVDCIPFTLHKIRNIVASQTANYGRDLQEDLEFDKYVHTVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTT2</accession>
    <name>A0A914HTT2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTT2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4145.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4145.t1"/>
        <property type="gene ID" value="Gr19_v10_g4145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036743642" evidence="3">
        <location>
            <begin position="29"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4145.t1"/>
        </source>
    </evidence>
    <sequence length="687" mass="75958" checksum="377904268EFB25D4" modified="2023-02-22" version="1">MRKKTSTKFQQFFLRILPIFFLGTLTKCQQAALGRVKITLECAQEQMTLHVQLNESFLPNGRFTDWIIVGTTTRPECRLKGNGEFRYIVQIAVLKDPCATKMTAPGVFQNTLRIASFPGLILSDDLNFEFKCALGLPEVLELRLPQTKASESENNEQIVPVRPSFSTTTTSSSSPRSSSFLITGLGHNVLPSSSANAQQQFPSPQTNLPPQQTQRNKFMANSEIAGEEMSVGNAWTQQNGKATAETEQRRREGGGRIGTEDLQRAQHQQQERKDAAESAVNGDSDDFDVSNQWEERRSNSLSSNLLVVTCGFLALFLVGCVFLAMFHSVKQFRATRRSAAPFSQFDSRRTSPGNSSLSPAGSDGSRERVGTDWRAHTANSDSTAIVTNHSRDQLQLGAMDGSYHTEALNLVPPSVPFPAVPLHSSTNSNELHHPTAHAGKDELRRTNSMKAFGGNENGGPLAEVPKLGEKQRKDNETIRGEFNAAACRSITEIYRTAEMKLKSMMQESEGGGNGKPARGGGRGEYSTPKKLEPLKERGNLLISCVNKIRGYGSRKLTEQEILRWRQLIRNDANFQNRVFESVSEEDLMRICELPQYRVLFTKLKWVQIMGCIAEEILDSPDEQNGNGGRQRNDSTETVRRMKPLPALPGPSKYGLNAAAPSQLHKAFNHPNASLKIFVGNVGGVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUQ9</accession>
    <name>A0A914HUQ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUQ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4175.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4175.t1"/>
        <property type="gene ID" value="Gr19_v10_g4175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4175.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16153" checksum="A03999DDAD595510" modified="2023-02-22" version="1">MALQRSGAETSFIVQISKQTIFERDHFLCCCSCAIAVIILQPASSRAQSGQSVVHAQPRPTVGGSPLSESRCAADNRNEARRFVSPADFFSRQSLNASRMTGRPNTRHRFQQQNALFDDLLLSESERDGAQTTLTIRGMAIATNLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWM2</accession>
    <name>A0A914HWM2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small-subunit processome Utp12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWM2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4829.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4829.t1"/>
        <property type="gene ID" value="Gr19_v10_g4829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="127"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4829.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27993" checksum="F9A4650FFEE1F0E3" modified="2023-02-22" version="1">MKPFFPWGRNVRGRNVLGAETAGPKGRGRNVGAETAGPKRPVPFDDLLVTQFGNPAVDLIMANSSQKAMDRSEAKTNGTTEQEGLQNKASAQPKLDSQAVLLTQTIRSHDTALFSSMVARMGRNWPTINLTIKELPTSEVLPLMRMIDQHLRQHGKEIKNLDLWLSWVNKILHVHSGYLTTVPDLTSHIGLIAEWMERRVQHLDKLFQLQGKLSFMLSSLPSQSEQWRARDEPPMMVFGADESQMIDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWM7</accession>
    <name>A0A914HWM7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SLC26A/SulP transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWM7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4831.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4831.t1"/>
        <property type="gene ID" value="Gr19_v10_g4831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4831.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32577" checksum="662BED0444DF6610" modified="2023-02-22" version="1">MWHDLALASSRANPLTLAISAFGLTFLSLGRLFVSPWFSKRFRIPFPLELFLVILGIIFSSLFHFKESHGVQIVDHVPEGIPLPSVPRFELLIHIWPSVVSVATICYIFVFSLGRIFAKKHNYAVNANQELYALGLCSLLSSFFPVYPSGASLSRSSLCEMTGAKTQLHALFSSALLLIVILWIGSLLEPLPMAILACIVAVSLRPLFMQFGELPKLWRTNVYDFYVWLVAFFSTAFLNITFGLAVSLLFSLFMFGLRKLNGIVGKRQNASPVSRHGSRSPKLPQIITLPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXQ3</accession>
    <name>A0A914HXQ3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HXQ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g563.t1">
        <property type="protein sequence ID" value="Gr19_v10_g563.t1"/>
        <property type="gene ID" value="Gr19_v10_g563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="564"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g563.t1"/>
        </source>
    </evidence>
    <sequence length="736" mass="80136" checksum="A1B414AB78912866" modified="2023-02-22" version="1">MAHPVPQQEPVPLPWASCPAVEDKNNSQTDEQQTASKKKRGTDGEENLSTKSGGKRLKAAQLVNTSNNNDSNRNNDENVANNRESRTDNGDDDDDDSAVELLNDPIIIPSPGLPMAHSTPMVAGPSRNAFALKKFATNGAAQLRTTTAMEPVHMFPTPCNPVWYNPWMRWAQTAPVNGLGFPSSSFFGMKMEPMQSLGEKSAPASAKTASSVKNVNAKVVDQRQDDDSGVGSDAATATMSTFAETFHDTVSLPIPSMAPLHAINSFETYCTVPGRLTLLSNQKKYRVSIGEIQRRLKPPECLNASILGGILRKAKNKDGGRLLREQLYTYGVELTAGRRKQGALTCFSSLVEDEAAQMALDFQTICERGYPIQAAATSALVGVHNAQEAAMSRLELFYASKFINRILDLQKADKSPASEQPKLEPNHFDDLHPQLQSALTNFSLMTHGFGGLAVQAVLETMIRVINECNGLLNRNYQSTAGQMAAPSRSHRPTSGPSILSLPSPNQSTTYQAAPSTRRKSDVIPRAIVFIAIMALLLNFAFVFITFLTASYAEEEDPKVTHKAFFDISVGGEKKGRVVIGLFGEVVPKTTKNFLELAKGSEGFGYKGSKFHRVIRNFMIQGGDFTRGDGTGGKSIYGERFEDENFKLHHYGAGWLSMANAGPDTNGSQFFITTVHTPWLDGRHVVFGKVLEGMDIIRQIEDGETAGGDRPKKDVVITDSGEVAVSEPFKVAREAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY40</accession>
    <name>A0A914HY40_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">tRNA modification GTPase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HY40"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5180.t3">
        <property type="protein sequence ID" value="Gr19_v10_g5180.t3"/>
        <property type="gene ID" value="Gr19_v10_g5180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000007">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="7">
        <location>
            <begin position="214"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5180.t3"/>
        </source>
    </evidence>
    <sequence length="451" mass="49950" checksum="231BB4BD21DF50F1" modified="2023-02-22" version="1">MLFSRRFFSTIFALSSGSPPSAIAVIRISGDRSESTLRVLTRSKRPFDDRRLFYTPIFGDDGLLLDKGMACLMKGPRTFTGEDSAELYLHGSRAVIQAVCETLAKISGLESAKAGEFTRRAFFNGKLDVAQMEALADLLGAETPAQLRLCHAQAKVGAYLSENFTRRIDFAEDIGDEEQSLAEEFSAEIRGIGQQLRRFLRSAKRGQLIRSGLKVALVGRPNVGKSSLMNRLAERELAIVSNISGTTRDCLETRIQLNGQLVNVVDTAGIREGSEDPLEREGIRRTLQRASEADLVLLVMDSGDLFGSESDRSLVNSLLAEFAFDSASQRLIVVVNKSDLVKDRTERLHLERTLKRNERFLLAWTSCVREDEDGVGSEGCEVFLSRERHVQCLERALTHLEETEAALAEWDDPAMAALTLRLCLDAVGEIAGRVVHEQVLDSIFSQFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYK3</accession>
    <name>A0A914HYK3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYK3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4983.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4983.t1"/>
        <property type="gene ID" value="Gr19_v10_g4983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF248">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4983.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34895" checksum="93E1D7179D56C6F6" modified="2023-02-22" version="1">MICLLVGVPLNLLLIWLLLRRTSKEMRVYSQILVQTCVVDLLVLVLGELVQPVFFVDNGIGHDLMAGPLQIVPNPANHIVFMLWFGLFYFSTEGLAVQFVFRYLTICRKMPMNTLKYFALLTVALLFETVVALALTLSSYPGAQHQQIDDPKVLLALGTQRKLTLALRSDSSDPFVVECFLLLFLSDTFIYATILICAVKIHSFLKRQFVEYKLSKWSELNGQITKTLLVQVVISALRASADVHFWSCRHYFCPSVRQLSDQCRNADHGPTLEVRLFGQTVLSLVTGTTPLANARKDSAQTAALATIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYT1</accession>
    <name>A0A914HYT1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ras-related protein Rab-39B</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HYT1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5038.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5038.t1"/>
        <property type="gene ID" value="Gr19_v10_g5038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000358">
        <property type="entry name" value="RAB39B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5038.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25793" checksum="14164BF877C976C9" modified="2023-02-22" version="1">MDFPTSTFPMYHYQYRIILIGDSTVGKSSLLRYFTEGKNAEISDPTVGVDFYARMVEIKPNYRIKLQLWDTAGQEKFRSITRSYYRNSVGVIVVYDITNRRTFEHVVDWLAEAEANLGGPDPAQLVFLLVGHKADLEEQREVLYEEGEYFAKHRRIKFIETSALTGENVNEAFLIVSREINARFETGALRICDGWDGIKSGLLRTQSISLLDTQETSSENSQCYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYW8</accession>
    <name>A0A914HYW8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYW8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5946.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5946.t1"/>
        <property type="gene ID" value="Gr19_v10_g5946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5946.t1"/>
        </source>
    </evidence>
    <sequence length="556" mass="62614" checksum="E79BB0B2A0FC8304" modified="2023-02-22" version="1">MSISAESTNEGDITADQEHLWPTFLNLNPSEGLRHLQDKIAQEFQQTINSSTLSDDFDIVAFEEELKMEMEMELKEVKGELKGMKQLEGQLKQYKEELKNMKQLEGELKEVKEELKQYKEELKGMKQLEGELKEVKEELKQYKEELKGMKQLEGELKEVKEELKQYKEELKPNMEELKQQQNQTEKIVSDQFLLMQNDQKALLDRIAALEQKQAANAEQQKADQKGLSATIHLSLLHHHQQQQQQPPFSGATPQGMILPLQPQGINPLQPQGMNPLQPQGMNPLQPQGMNPLQPQGINPHQPQGMNPLQPQGMNPLQPQGMNPLQPQGINPHQPQGMNPLQPQGINPHQPQGMNPLQPQGINPHQPQGMNPLQPQGINPHQPQGMNPLQPQGMNPLQPQGMNPLQPQGMNPLQPQGINPHQPQGMNPLQPQGMNPLQPQGINPHQPQVRGASQQPQPVAQLKQQQHMAAMARQVMQNNDVQLLMSRFKEATQRGPDDVEAFFVELRKSPHLLNAFLKHTKKQADFLNRQMFPGLGAGNAPFGTAAKQIGGSDIDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZB7</accession>
    <name>A0A914HZB7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZB7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5472.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5472.t1"/>
        <property type="gene ID" value="Gr19_v10_g5472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12337">
        <property type="entry name" value="RRM1_SRSF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022:SF1">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="4">
        <location>
            <begin position="81"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="227"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5472.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46731" checksum="FCE9C5E97192AF8C" modified="2023-02-22" version="1">MTSARVYFGHLPFRTTENDLEHFLRGYGRFREITMKNGYAFVEFEDLRDADDVVYDLNGRVLLGQQVIVEMARSENKYRRSGRIVFRVENFKAFCEGRVPEQLISDSAEFINGLPWRIMIDVSTDAQKFLKFFVLCDGDKNDKAWSCQAATRLGIVSCDKRIENFMEQEETRDVFNAKTRAWGSRTFIKIEELLDRKRALYNEVDDVVTFLVDVIAEKPNGMPGVRTEDILLVNGKETNVNKHQLAAHSDFFKTLFFGENAEQTPEIEIDDLTDAVQQFERLLATMEPKNMELDDECIESVLHLANRFLLGSVENRCVEFLKRTSKKAALSKFRLADEYGFVALKSHILEYMTRDDFAGENYLENLSENNKLGEEAANELSERHKELFGPPSKRARKSFMYTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZD3</accession>
    <name>A0A914HZD3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZD3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5428.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5428.t1"/>
        <property type="gene ID" value="Gr19_v10_g5428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5428.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20446" checksum="89B98515E1CFDE7F" modified="2023-02-22" version="1">MGDIGEGVNNKIADCSSTSSSSFSSSERVPNSEFVSSICAQFEGNGGQIAIKRLKIVMRALGLEPRQAEVDEYTRKLLQNSKARQSKPLSFTALELAELLADRLQKDGVKGVDEELHSVFRLFDTDGKGFISVNDLRRVADELGERISEEEFREMITVAVSGRSGIGSDRVSETDFSAIMKKISLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0U5</accession>
    <name>A0A914I0U5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NudC domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0U5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5565.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5565.t1"/>
        <property type="gene ID" value="Gr19_v10_g5565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5565.t1"/>
        </source>
    </evidence>
    <sequence length="584" mass="64838" checksum="189E20C93065E13A" modified="2023-02-22" version="1">MANLSSSSEAADVLFTLRADQKLLDPTFDRYILRPERLAMSKKKIEGKKVRCKLPSASQWGYQQIRAHTLAAHLFFDRFGGSCRPSFFALLDDLRLVSLTFDQTSKCWSDPVEVAHIGTPPPSLSSPSCVGVDVEDASFPESLHFLDSHTALTSCGQNAFSVWYTGDRQKNPTTKWREMFKYEIPPLHKLHDDTKESAADEAYPALILDARRRQEEDTSGVVFDVLLLTVAPVEKAKSNGAESAEDDTAGGDKMEMARGKSSGGSVFRTNLIWVSVQAEQQQLINNEDADVSKFVVQRVRQILCDGKVEFACFDASVPRRLVVFGVGRSPRFVWDSAKPIISEAQQQQLQSPLVGGDGNETMDISAASDAEEPAKNRVQPAAAEDARQQFNADQLEECDRLPEVEDDVSAFWLDGDSHELVAMTIINELLFTAKITAGGAPVFATRYDVDTIVWRHNEIAAGKKESAVSHLFTLNAFGYIQAGHQDKRFLGCSPDGRYATLINRTNHCFLYFQSAAVPNEHELKNRRTGKRAEHIAKQLVLSMSDLDTDFDPNDALNEFIGFHAASDTLFLLTRSAIYAVEMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I174</accession>
    <name>A0A914I174_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I174"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5928.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5928.t1"/>
        <property type="gene ID" value="Gr19_v10_g5928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5928.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30657" checksum="B0A2F3BD7E420AA8" modified="2023-02-22" version="1">MAKKTISDEEIMALCTAIESRYSELFGRAKGASYKQSKDEAWNELNSELLAQGFRVFEKSIADLRDNVYGYRKRAVESKWLSARKTGSAGINWKNWESVIIRMEKFSEEVEIMEDVGDSGAKLTTWQKQVEFDASKEETDIKLNVSDPPLGEAASSSASAAAAGSIYTPRFQMRKRPKVERPSQFSTAVGGGGFGGENRRSFEELKLQLLEKEVELKTKQLQLAEFDIQYKRRSVELVELQIVELQRKMGRYEVEAEGENTFTVLKKSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1I5</accession>
    <name>A0A914I1I5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6631.t3">
        <property type="protein sequence ID" value="Gr19_v10_g6631.t3"/>
        <property type="gene ID" value="Gr19_v10_g6631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000013">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000060">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="557"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1096"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1134"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1163"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="217"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="21">
        <location>
            <begin position="1442"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6631.t3"/>
        </source>
    </evidence>
    <sequence length="1875" mass="208720" checksum="706EE90EE7B3401C" modified="2023-02-22" version="1">MEENPGKNRCYSCASDNMKENFLTRSRGPPGRVREPRLFDSMCDSDTWVIREKSAIQCQGACFKWQQTLNNSGVLSYATIRGCYERMFDSAVGPTPSQSVDGAPPSAYTTECKHVQRALVCLDEYSSVEEATCWCFGDFCNKALRTAGDETMESKHSFCSSYFTVTTPHFCIMEKGESSQKRRDSAGVSGAFDVTLGELRTLMQFRGKEALEKINTDFGDTVGLCQRLSTDPNSGIPNTQEELKRRRDAFGANEIPPIPPKSFIALVWEALKDTTLIILLIAAVFSLALSFYNPGSEVGGGKEENEQEAGWIEGAAILISVVVVVLVTALNDYTKERQFRGLQAKIETEHKFAVIRGGMQLQVVVNELVVGDVAQIKYGDLLPTDGVLIQSNDLKIDESSLTGESDQIKKSVDQDPMLLSGTHGSGRMVITAVGVNSQTGIIMTLLGAAKSANERKEKQREEKRTRRRSKASDIKLDGYNGAIVPGSAGRAKDDLEVQPAKKERSVLQAKLTRLAIQIGYAGSFVAACTVLILGIRFCIQRYLIDQKPFMVSDFRYFVNFLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATSICSDKTGTLTTNRMSVVQSYLNEVHNKETPKWERLDEKTKNLLVQCISINSSYSSQVLPAKKRGEQMQQLGNKTECGLLGFVLGLGQSYQTIRDAFPENRIFKVYTFNSVRKSMSTVIELKNQNKGGSTVGYRVFSKGASEIILRKCKWMLGRNGQLSPFLSKDLDCLVRDVIEPMASDGLRTICLAYKDYVADGTSKVDVNQLSFGGEINWDDENAVVSDLTVIAIVGIHDPVRTEVPEAIAKCQRAGIVVRMVTGDNINTARSIATACGILKPGEDFLALEGKEFNQRIRDEHGEVSQEKLDQIWPKLRVLARAQPTDKYILVKGIIDSKLNTNREVVAVTGDGTNDGPALKKADVGFAMGITGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSIAKFLQFQITVNIVAVVIAFVGACAIQDTPLKAVQMLWVNLIMDTLASLALATEPPNEDLLKRKPYGRTSPLISHTMIKNIIGHALYQLAVLFTLTFAGFYLFNVNTGINRPPYSPPSEHFTIVFNTFVMMTLFNEINARKIHGEKNVFRGLFTNPIFCVIWVFTIIVQFAVVQYGGRWFSTKPLTCVQWLCCVAFGAGSLLWAQVVTTIPTKFLPGYVRFCGWPIPSQSVFEFKRNVEQQMSYFGGCRKCPILADAANVLFWRMPQMSYFGGCRKCPILADAANVLFWRMPQMSYFGGCRKCPILADAANVLFWRMPQMSYFGGCRKCPILADAANVLFWRMPQMSYFGGCRKCPILADAANVLFWRMPQMSYFGGCRKCPILADAANVLFWRMPQMSYFGGCRKCPILADAANVLFWRMPQMSYFGGCRKCAEFTERRARLLELIENARTDFGDKQPFALLFAKRKSFSAPDVPHVYRQCSHFRYLCGVDRPGFRLLVGPKESVLFYAPQTAQQILWDGASPSSDQLKSASGVDKILPLDEFDPYMAGTVRDGLLGLELRSLMDHAVEEPELKKVWQMIADGAWTHVELGEHVDVLQWRKSDTEKALMRRTCAIGAEALNAMLRECRNATNESHIVGFLEYECRRRGANFLAYPPVVAGGSNANTIHYIDSNMSIRPNDCVLVDSGCDLDGYVSDITRCFPISGAFSATQKALYDALWHVQQQLLHFVQNTRPLRLNALYAFMLERMGDALTSIVFFKRDGLSGDALLAECDKLCPHHVSHWLGMDVHDTSTVPRNIECSPDVVITVEPGIYVRPDNEAVREEFRGLGFRIEDDVLITDTGAEVLTANCVRESNEIEYCMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1Q0</accession>
    <name>A0A914I1Q0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1Q0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5793.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5793.t1"/>
        <property type="gene ID" value="Gr19_v10_g5793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5793.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22342" checksum="79B742BFD80D640D" modified="2023-02-22" version="1">MMFLEELRLAGAAAGFCFFHQQFGNKSPNFILICADVWLGVFAFIDPFELGLKMALISERFDVLVDVHFKLRKWSLGRLKILRATDGNGAGIVKNFDDPLPIPQGPLHANYADQSVIKFLQRIRRLFDSAETSVYVWTSDDQSRSWEIIRQKIWPLINDNIYNLVTRKASSIWPAIDKAVPWLNLPPALARLVAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1S2</accession>
    <name>A0A914I1S2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1S2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5812.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5812.t1"/>
        <property type="gene ID" value="Gr19_v10_g5812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5812.t1"/>
        </source>
    </evidence>
    <sequence length="543" mass="63646" checksum="C51E1078E25ADEEB" modified="2023-02-22" version="1">MKKIPLSLRFPFYPSFLHFKLGFSSICHRCIVLFLLAVVVFAYFGLAPFYLYSSPLNDKSVSKMDRQKKASVETVEKARKEWLKPRMDCQRVFNGDKALVQRMAKRRRKMKDPNDLEMSCQMIQERNWDPGEDGETNITEMERQMPMAFARVVYIDYLFLEAELLVNYAHNNWYCYVLDSKSSRTFQRRMQQLASCFENVIVLEEMFDIDRRGPNMNKAMMECVRTLTDGGKHWKYLITLQNHDVQAKTNAEMAQIFSWLGGANDLEVELQSPLTKERLEHYRTHFNWTFDSLHLFKEEAMNHRTDENGRPLALSLSKGYMTASLARQFVDFVVNELNLTTMLEQLNSGIFGVDEHFWQSLSSSEALDAPGGFPHTCFVKDIDEEDTSIRKYRYITRFAMWAPSSKCLSGNWRHAVCVFGLEDLMGPDSEIRRLPHLFVNKLMQQFDFDAILCWHRWMRERRRSKTMKLDERFYRDWPQTKYQTERQLRKAGEHRAEVNCETGGMVWWGKDDDGNGTDRRKNGGGEGEEAMGRTKKRKEKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I362</accession>
    <name>A0A914I362_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I362"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6181.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6181.t1"/>
        <property type="gene ID" value="Gr19_v10_g6181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF9">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="281"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6181.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41674" checksum="D36DDD046D695BA5" modified="2023-02-22" version="1">MISATDELNVENFDCFCHKLNLALSDGLEHRTKSVPEIKKEIQMCRELVGFYNRSKNFQNVLRRQQDLIDAPKTGLIQDVITRWNSTLYMVDRIIQQQRALSLAQIDFPELKLPNFELLKNLSAVLAPFDKFTKQLSNRDESISSVLPIYRCLLTMLNEKCTDSDPMKLFKKIVVNGLKTRMAKYECKRFLVIATLIDPRYKNHPNIFSLEDRFQNKVLLKTEVELFINPSRRFSDSDSNNGPVIQHSDNPMANFLFTDPEFSGAILSQNDSTENEIGQEIDSFFKTSTIASDTNPLEFWRHNTTYPHIKQIVPKFLCPPPGSVESERTFSKLSEIYCPNRSSLSETHGKQQLFLHFNFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3V7</accession>
    <name>A0A914I3V7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3V7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6638.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6638.t1"/>
        <property type="gene ID" value="Gr19_v10_g6638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="133"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6638.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29992" checksum="94CF609FA5C3E145" modified="2023-02-22" version="1">MSPIDRLCVELRSVYSVHHLLNFVLSVAFPLSKLLPPLPNLLYGQRQPGFDSREREVLIFLAVVILWKNRKAINSLHSLSISFLFAKLAGAALFFRCSSLFGLLYAVFALLIFVLVPEPLPPDSTNIRYFRANELQRTLEEDKSVVWVIEFFTTWSPDCRYVAPVFSTLSEKYSLPNLRFGKLDVGKHTKDGAHFRVNTHASSKQLPSVALFKNGVQVERRPLVEQRRAVPFLFNENNIILALDLNDIFAECKSVRIRRKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3Z4</accession>
    <name>A0A914I3Z4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3Z4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7288.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7288.t1"/>
        <property type="gene ID" value="Gr19_v10_g7288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="121"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7288.t1"/>
        </source>
    </evidence>
    <sequence length="525" mass="60772" checksum="F7E86332287BBDE8" modified="2023-02-22" version="1">MLTVDSNDLRELLTFVHTHGHLYETLNVEFFSARIYDQIDAEWLRFMCRLDDAQLNTLAIDFEQYSECPPSLQHFFASARRLSLLHKYCAPRQSGYNSSTASSTPIQQPAQTMPMRKVKRKKAHELSAFSELLLAECAPLGVDRVVDIGCGLGHLGRILRRNNEEGVRHRQQQQGQQHQQQQGHHQQQQGHHQQQQGHQQQGQHQQQQQQQQQFEGTGLRLDYVGIEADPALCHSALKIDGCPNDVQMKNIVFSSDTSKQCHKILTLPDRRTALVSLHGCGELQRQILLEFVSICKQQQQQTHNREQQQLCPLLVTVGCCYHKLKNWTDSTIDRWMLSRQMRDHFLCVYGHNNFPIPGLRLACQAKLVRWMAFTEQEHFAHRQAFANRAFVECMRLDHKNAIEFTEHDDLLRNERGPPRRLNKCITGEDGFRAELLSRSAVLEEEEREQFEQKLDEIMEEHRAAVRFIEPFTTLQFALQCPLESVVLLDRLLFLHENRIDAELVELFDPSISPRNIAIVARVVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I509</accession>
    <name>A0A914I509_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I509"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g686.t1">
        <property type="protein sequence ID" value="Gr19_v10_g686.t1"/>
        <property type="gene ID" value="Gr19_v10_g686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g686.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10401" checksum="F36E27FEF1BF4780" modified="2023-02-22" version="1">MEEPADDLIMSEADQREHKARRSDQHRSEGRENALGHCRLEILLLRLLNNASGQNDQWEKMNDDGGLKKWAAATAKKNAELATTRNEQMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5J5</accession>
    <name>A0A914I5J5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nucleoporin NDC1</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5J5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7712.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7712.t1"/>
        <property type="gene ID" value="Gr19_v10_g7712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7712.t1"/>
        </source>
    </evidence>
    <sequence length="554" mass="61806" checksum="1CECDB6C633AB614" modified="2023-02-22" version="1">MIDRCYRAAISVAMFSALILALLAVLLQYSPLAPISSIKACWSMLSFKLLFVLLLQVGTIFLECVLLSTWIFSVHFETNFNISKFECLLAAVIIFSANILQTFLLSFVIRKQIVWFSTSFSILLWLVSSAVAALYYSCTTNFQLRFAENRFDLSAIKRNFDSLIIGPMLGQIVITAKIFCVAWVTVFNLVLLLRPLHSFLPSLFAFWHFSDFLLLLFAQGLILRLTPPVVNYFVMKPIEFAMPTVFFAAAEGLTISSPAVTLTTALESKDPIIKLFALHQLQRMCSANTLTRKPFYALSQPGGHPRNWHSLRDVAVAHVRNVRNVFQLAAQCKTAHSVAAGATSMCKSFAETSVNKSNEGNEDNTNKSLMNAVTTGSFLNVSTGSTGVLNQLYEAKLSFFIPPTLNPRPADAFLSEREQCRRLIIMPRFCESIVLKLKQFLFVPSPIVSSYDTHCALCAIKALSAVISHSLQEDEFGVVQKDMSQSLSELTRLSIAIDAYVRASGRSSKSIERNIVVLDEGLATELKEIRKVFGSHISELNLYPTELEVFQMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I789</accession>
    <name>A0A914I789_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I789"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g795.t1">
        <property type="protein sequence ID" value="Gr19_v10_g795.t1"/>
        <property type="gene ID" value="Gr19_v10_g795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g795.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45250" checksum="7C469DADCA728AFC" modified="2023-02-22" version="1">MLFPSDPLDQRLAPNTFVLGRDSAVIRAFALNNCCRFFLFVQSISLQQMETPIWEFKSSGPCSFPCNPPKVCFTPIHYTAPDICIPPGVNPNDFGHYLTLTENTVLISLLMVLLGGIGIGLLLSFSWCLFRKSVPRARSVNLRAPQPPKARPTVFSMAVPHVSAHGNGVEVLLKNVYSNLITCVRNVLALFATVMELFFFRHAEYDRLYNCTGLEINSIPLERRQFVPESIAVCVLCVIYYVLYVPCMCSLWKHMRDNSCYKLLFYIGITDLAILWIPGFFCGLANLCGAVFCSCPTLMYFVGVLALALWVAESSADLILAFNRCLDLVSPRFSHILFSGPRTSLWITGCSLYALYWVFFMKPIVYSKFTSAGSSIHLLAIAPVMINKSTNNGCTECITLPWHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7B0</accession>
    <name>A0A914I7B0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7B0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7288.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7288.t2"/>
        <property type="gene ID" value="Gr19_v10_g7288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="125"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7288.t2"/>
        </source>
    </evidence>
    <sequence length="529" mass="61260" checksum="4F92F2F845296FE6" modified="2023-02-22" version="1">MLTVDSNDLRELLTFVHTHGHLYETLNVEFFSARIYDQIDAEWLRFMCRLDDAQLNTLAIDFEQYSVLFKECPPSLQHFFASARRLSLLHKYCAPRQSGYNSSTASSTPIQQPAQTMPMRKVKRKKAHELSAFSELLLAECAPLGVDRVVDIGCGLGHLGRILRRNNEEGVRHRQQQQGQQHQQQQGHHQQQQGHHQQQQGHQQQGQHQQQQQQQQQFEGTGLRLDYVGIEADPALCHSALKIDGCPNDVQMKNIVFSSDTSKQCHKILTLPDRRTALVSLHGCGELQRQILLEFVSICKQQQQQTHNREQQQLCPLLVTVGCCYHKLKNWTDSTIDRWMLSRQMRDHFLCVYGHNNFPIPGLRLACQAKLVRWMAFTEQEHFAHRQAFANRAFVECMRLDHKNAIEFTEHDDLLRNERGPPRRLNKCITGEDGFRAELLSRSAVLEEEEREQFEQKLDEIMEEHRAAVRFIEPFTTLQFALQCPLESVVLLDRLLFLHENRIDAELVELFDPSISPRNIAIVARVVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7I1</accession>
    <name>A0A914I7I1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7I1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g801.t1">
        <property type="protein sequence ID" value="Gr19_v10_g801.t1"/>
        <property type="gene ID" value="Gr19_v10_g801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g801.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8524" checksum="2708124791A01B55" modified="2023-02-22" version="1">MPKSIRPGGHLGLGGGLLRRTASPPTGMLTQLGGAQTTQACFWHTYYMYVLHIIAAGGDSDGIFPDGDAIHLRHNFSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I863</accession>
    <name>A0A914I863_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I863"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8377.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8377.t1"/>
        <property type="gene ID" value="Gr19_v10_g8377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8377.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9990" checksum="B272032941F661D3" modified="2023-02-22" version="1">MQCVPGSIVVSIRACHFHIPVCGTHLSGFVDVFANRKELKDAFTMQRLELELDDGGRFLMFDRLAAAEQDEKAATEKAKQTPTKRPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8Y9</accession>
    <name>A0A914I8Y9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VASP tetramerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8Y9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7733.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7733.t1"/>
        <property type="gene ID" value="Gr19_v10_g7733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7733.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="30748" checksum="10ED9492C9278DFB" modified="2023-02-22" version="1">MPFLQPSNSNGSMVQSQQQKTSPLISIRPPHPPPRKHQTSYADRLKGVKLRKSSTGNGVPRIVSPSNSVGSSNGSASVSSKFQSQDLISELSDRLSKRKMTVEASTSANGTQNCLNAQQTLPVNNVKDESIGACYERIPSMPSLSSQDDANVGGITGGTVSAIQPTILHVNDLESKKPVGFVVASYGNDVTADPSCRNVDGTAETVGIVIVSAPTNKATNSQTSAEHNNNVNDEIRAMTPITPNDLDRMKAELIEQFAKELQNLKRELTQTIRDGRSEITGPAAYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9N2</accession>
    <name>A0A914I9N2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9N2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8573.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8573.t1"/>
        <property type="gene ID" value="Gr19_v10_g8573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000008">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="70"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8573.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25534" checksum="6571E6DEF505694A" modified="2023-02-22" version="1">MATTGWPAVINSNSHNSLLPQKNYSNLNRTINLYPLTNYTFGTKESQSERDHSVQARFQRLRDEYDKTGMRRSVDGVLLVHEHSLPHVLLLQIGTTFFKLPGGELNPGEDEVDGLKRILTETLGREDTPRGQWIVEDTIAQWWRPNFDPPRFPYVPAHVTKPKEQTKLFLVQLPDKAFFAVPKNFKLVAAPLFELYDNSAGYGPLIASLPQILSRFNFLYNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA25</accession>
    <name>A0A914IA25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7999.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7999.t1"/>
        <property type="gene ID" value="Gr19_v10_g7999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037918769" evidence="2">
        <location>
            <begin position="23"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7999.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24618" checksum="C477994E05D8E81F" modified="2023-02-22" version="1">MHCSSSMLLLFLVLHIVLLAVSENVGNDRQAAALESRSSHNDRAAAAIEPRQRRAFGSILGIAASATKMGCKLFPTKACPVLAKIPFFGRKRRAAESENAVPAEVSETEGFTELSELDQERKLLESVEKLDQGEVLKEQLKETIEEAEKTVDKSLDRIVMYTEGSVDAKMAMQQKVEKVKELEEKWSADVKESLKPNMDEKIIDEAAHFFSSVPQQIDLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAN2</accession>
    <name>A0A914IAN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g815.t2">
        <property type="protein sequence ID" value="Gr19_v10_g815.t2"/>
        <property type="gene ID" value="Gr19_v10_g815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002619">
        <property type="entry name" value="CX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520:SF8">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01705">
        <property type="entry name" value="CX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036742999" evidence="2">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CX" evidence="3">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g815.t2"/>
        </source>
    </evidence>
    <sequence length="218" mass="23841" checksum="C156B66A37CF6959" modified="2023-02-22" version="1">MKLHECHRQKCFILFIFVNFGAQASPSFGDSIGAGPGNFGSGTRLGSASRVESFKTSFVSSSAANTTYYRNRPFDYYGNHYYLGGDGAIKLNAGEIHCEMPLDTLFNQNASLSNSCKLANKTLSAVTNGTRSMTNGTRSRTNGTWPATWTNGTRPNHIVWTCKEHVEQCCGIECCPAEKSANDVTSIVIIVLLIVLCCAVSVIEYALNSYAQKLFEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAX7</accession>
    <name>A0A914IAX7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914IAX7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8280.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8280.t1"/>
        <property type="gene ID" value="Gr19_v10_g8280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF3">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="21"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8280.t1"/>
        </source>
    </evidence>
    <sequence length="618" mass="68285" checksum="476E2F19AC9AB729" modified="2023-02-22" version="1">MSNFDCSPENYKNGHFPSNPPPVVRTSFGDVFGIRRRLNSGVQVELFLGIPFAKPPTGEFRFEKPVPPIPWAPSPFRAFQFGPAAIPLSPGIEAIPPSEDCLQLNIFRPASCLCAQPPSGALLLPVMVYIHGGGFAYGSTRQYGYEGWTENFAPKGIMVVTVQYRLGPFGFLTFGSGSALPGNLGLWDICAALRFVHNEIRAFGGDPDRVTVVGLSAGGAAAALMALSPHTRDWICGSVEMSGTALAEWSASGRTEEASREFARRALIMPGGAGREKDAVNCRHWEGGQQQQQADQQLKRRLKALTADQIVAIANAMGTTRADPNLLVWGPRIDGDFLPRDIPALLREVRAKPVLMGVTAEEAVYFTIQAKDPLINPFGIARERLDNFGTNEFRAFVYGVVAETAISAFYLSGIGHDENEVVPVKQNGKQKKLECNQSALEQYTKLVSDLMFNVPLFRIAQLRRRCGVPTFLYFNEYFNNSQFEPWTPFRGATHGNEYPYLNGLFPVGEFQFNEADRQHRALLVQMLSTFICNGRPSLTIGDDPRRLWPSNIEKSEEEEKALKFVRIGSEFDGRGTAEIAVVAAVEQSGAFWAEFSREFGFDLIRGIAYDETTVYPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB82</accession>
    <name>A0A914IB82_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB82"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9231.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9231.t1"/>
        <property type="gene ID" value="Gr19_v10_g9231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9231.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7427" checksum="0380FEC1DF2914A1" modified="2023-02-22" version="1">MKALKVENVGINGGALTSVDGRRRKPWLLLVFNFAFFLYHAIAIKKDCPGFFNTNTSNTIQLGSVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBQ6</accession>
    <name>A0A914IBQ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBQ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8409.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8409.t1"/>
        <property type="gene ID" value="Gr19_v10_g8409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8409.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7882" checksum="A65F85165B1661F9" modified="2023-02-22" version="1">MELHRGDNSKSHPHSAGRLIIMAFANRARTSAPEGISGAQTAGGGGHGERKEGTNVFCVFRWTDVTNGHFFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDE4</accession>
    <name>A0A914IDE4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDE4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9818.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9818.t1"/>
        <property type="gene ID" value="Gr19_v10_g9818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9818.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16330" checksum="BBA75958BA9BB377" modified="2023-02-22" version="1">MLEHCTEQQKRPVLEQLLDNVPTLVTDQYGSFVIERVIEHGLPEDRERIVRTLQGDILKTHYKSICSIIEKCLIFGTTEQKNALIDQVCADDGTGKPPLLQMMKQQFANDVVLKMVDGADSAHRDKMMFAIEEHIPALLKRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDQ9</accession>
    <name>A0A914IDQ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDQ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9909.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9909.t1"/>
        <property type="gene ID" value="Gr19_v10_g9909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9909.t1"/>
        </source>
    </evidence>
    <sequence length="387" mass="42783" checksum="90078F81322368C7" modified="2023-02-22" version="1">MQKTVSSSPSFDGKGRLGSGRFPGSKCNFVVGEKNQDMHNHNINAPIFNATYSSLWCKGGYFWENSYHEKNITVCDAHEHYCYVQNCTLELVEQVGSTESEHHILTKWGCTDKMPNQLLDKPGQFIGQNAANRIIDHKCTPKVGKVNIPMSNAGTEVSIPSQKCKKAYFSKWLNESSDKSCSQSQRYCYVLNCSTAVESDKPGQIMTEWGCTDRQYGTGDFLQGKGRQLSDAYSRPMPNNSTCTSTVSLNSNEGVMLPIPSMAEKTSNSTLICKQGSETPSKKTDYSGTCLPGENACYAIHCFHSEHLKKPVKEWGCTSNASQICAQKISELGYNMSNKNETCNCSFDKPKQKRSLKKAMKMKSSDVEGGWHHASDQRALAGASLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEF7</accession>
    <name>A0A914IEF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nitrogen permease regulator 2-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IEF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9861.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9861.t1"/>
        <property type="gene ID" value="Gr19_v10_g9861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9861.t1"/>
        </source>
    </evidence>
    <sequence length="633" mass="72675" checksum="C8657636C7AE0E5B" modified="2023-02-22" version="1">MPRTHRLVAPLRVFYKRVKEICIAFALIYFVAYAFGAPIWSPRTAVFAADQLLLTYFPLCFVCQWKLAEFWHCVDNRPRTLEQLYVSRAVLGSVLGAWLGATVVPLDWDLWPLSSHFGSLIGIVLGALSAYLRIFTNPPFARPTKRKPSVVPYQSEPFVHCEENRTPDHLVHRGCFCLYRIYFINMEAGNEAAQMPMPMPMNGAATHPDGGSSLSSLSSSLGEQLSSDEHQQQQQRCSRHFFSQEPPKLHAIIYAEFDNDIGRVVRFQVPDEIFDKQRFDTISSAIIPSEEMRDRMIKINMYDFKITGHPVGIKDKKYQREVFIFNLCFVVAASEEDDTDDSIYYEPLVQKCAEYLVELEQERCFLSEEKHRLPALMREIFDGLNQKGECVCPITDQTTIYLRLCPAFLCREPPPHPLSPFLVPIFTRLPPPISRGALNRMDVLSQKICPQIDGVRCIKDIACAVQIDTDLVGRCVRNLCFHGCVALLPQFLYSNCYVPTERLRHFFDSPQIVEKCRNFVRLRHDSPPVLFSDVARLYLGLKTGSPLGEWLLRMRPRQLHVDERKLVQFGLFYGILRKQHIYPVAIRRDDGTKIASLCDGEHSLDELALHYTCSPVELQRLLAENGNFRFITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEI9</accession>
    <name>A0A914IEI9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEI9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g989.t1">
        <property type="protein sequence ID" value="Gr19_v10_g989.t1"/>
        <property type="gene ID" value="Gr19_v10_g989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g989.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="42059" checksum="0CEB4D73CEE2C903" modified="2023-02-22" version="1">MGPKKPPSKRKANPCKEDEESRSKKSRKVVIDEASDDEEVGVGDMTAADEGHKHRNGDAKALLTETGEEDEIVSEVGIYLLPLAPADAANSASVNSANPPSSVCINRLQFPQQHPSTLRRHFNRPLHGGDRDEDVDDDDDDDGANKKKCYAQFKAQVKHLRLGFGSDGEEEMAVPHGSSFRPGGGGIAELLKKQNNSSPALFSPPHQPPPSASTSSCSARSAPSAAEMFTGEGFSHHGLLNYAVGFFKEGRLFLLPVDKTYEMRKPLSGTIEREAAATALKASASSSSVSLRSTADSGTASTSSSAVAAPLRIRFERAENDLQRRRREQSSFYKQKLVEQDQWIPLKLEHKNLVNMYERDVNQVLCRTSSDVTPAKAQLKEEPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFV4</accession>
    <name>A0A914IFV4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFV4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9525.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9525.t1"/>
        <property type="gene ID" value="Gr19_v10_g9525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9525.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="39805" checksum="167321B83D8F6F22" modified="2023-02-22" version="1">MGSDASKPNQQQNANTTTSNKKFGKKVSRRMSMCAAGVPPRTPTIVGGSTGFLDVNNENGENADGDSSPRLSLSIDQLSARSRSGSQASGSQSPNKLPQKQRRCSLNLKNRQLIQSCFNNPHENIGVRILKRSAEKRKDFGRFYISIGTEHRERIADIVKQLLKKSVANIYGTDEELQALANEFGPRFVDLRLLGFKADFFAVLADSTTMECVLLDAAVHPAAATLTAFSLFITMMFSAVRDGFYSEMRRLRRSSNSFSINPNGSSAMMKKLSVDDNIKVNRALSGARSVSPSPEPAAGVKSSNSSGQGSQESILEQQNINNNNNGTNSRKISPESLQAKEEIRLLTAEFMGRAMLVGGKESQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IG71</accession>
    <name>A0A914IG71_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IG71"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9584.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9584.t1"/>
        <property type="gene ID" value="Gr19_v10_g9584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="181"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9584.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26864" checksum="A08CF39C70093257" modified="2023-02-22" version="1">MSVVVMCNLRRDRLKGVRRSLRRLHMTTTLIGEKTEQNRNRTGQAGTAKHWKRLAPSKIMGNFLSKIFGKKEIRILMLGLDAAGKTSILYRLKLGQSIKSIPTVGFNVETVVYRNIKFSVWDVGGQEKIRPLWRHYYVGTQALIFVVDSADRDRIDEARQELHKIINDREMRDALILIFANKQDLPEAMKPAEIQDKLGLLRLRDRNWYVQPSCATGGDGLQEGLTWLSTNCKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGB3</accession>
    <name>A0A914IGB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9616.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9616.t1"/>
        <property type="gene ID" value="Gr19_v10_g9616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9616.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12629" checksum="79221524170BED76" modified="2023-02-22" version="1">MALNYDALIAQVPDEDSAIASSKNEVYYTNNLIEINKNHLNFQQQKMPDNSKKEEKQLKSILSNSSKNIHRGCHNAASYETLDMLKHQETMAGKCKTSFGEDDFYKNYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ00</accession>
    <name>A0A914GQ00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 41A</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQ00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10358.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10358.t1"/>
        <property type="gene ID" value="Gr19_v10_g10358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF20">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="103"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10358.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34571" checksum="89A98A6F73ABC661" modified="2023-02-22" version="1">MTKLFILPAIFVGATFSLWLLICNAPEWGDESQLIGTIHQQLKERDEGGRNAPLSPSMRIELPTQFENFTVMADQFRAYKTRHTSYITTLFICGYLYKQTFAIPGSFFLNIAAGAVFGLWTGFLLCCVLTTIGSTLCYLFSEFFSREYVLYYFGEKITYLQRKVDDNSHRLLPFLLFARMFPISPSWLLNIVAPFLNIPLPIFAFSVFVGLAPYNFICVQAGFILSDLTSWDDVFSTATMLKLCSFALLPLCYAMFVKRQRKQTIIKTIPTPIKYFYSSNSLPILNTSKPQHLDPINKSDLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQM3</accession>
    <name>A0A914GQM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Groucho protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10498.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10498.t1"/>
        <property type="gene ID" value="Gr19_v10_g10498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001072">
        <property type="entry name" value="Transcription factor unc-37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF21">
        <property type="entry name" value="PROTEIN GROUCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="8">
        <location>
            <begin position="161"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="660"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="737"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="819"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10498.t1"/>
        </source>
    </evidence>
    <sequence length="895" mass="95611" checksum="9C385DF92C1A76C3" modified="2023-02-22" version="1">MADESIGDNNTEDAPPPNASHLTNQFFLIRSSKSHPSDLISECRPLPSRQLSSTHFFIASSPFSIRFFSPAFHQITTTGEKRRNDQRICASGADSFYYFWVLILSIVTLPGVFSQHQQGSAATSTSVTGASMFTGQNRHPGNSSSHHQGTASSVATTGQMKPTMKDLLDRVLEEYTHLQQQLHSVRVELDKSQQERETLQRYSMMYSETFFTLNFEMLKHGEIVKRLSGILSHVIPLLPQEHQAPAVQAIERAKTINPQDIQTLLSGQVQQQQFAAMLPGIAGSMMNPAAFGNPVGAMNAMMGIKPEEAMQAAAMFSSFFKSPMHGATAAGLPPPIGLGAPCTSGAPACAAPLGAPGPSALPPNGDDGLTPTTQPGRTPSALNSGIGPCRPRSGSPASTPNSMAAKRTKLEPEEGDGELEIDVQNDDASSSAAPSHHTNGRTSQPPRQNHSGKDADRDSASASSSRDSATPRSGKQQLSSTPGSSAAGFAPIMPTADANMAHMFLNTAFGGRFPANLNNQMFLGLGAGNAPLGTAAGIPTTNGKPAYAFKMSPGESMMPVQFPADASHGADVPKSLKRIGDLPHGDVVCAVTMAQNGRHVFTGGKGAVKMWDIGERLGLVSSGGISPASSTAADGTNGRVGSAEPWSPVNTFQCLKDSYVRSCKLFPDASTLIVGGETRTICVWDLNSEKVKTTLDCEAEACYALAITPDCRLCFSCCSNGSIVIWDLQNEQKIAQLDGHTDGASCVDLGGDGVRLWTGGLDNSVRCWDIGERAELNKYTLESQIFSLGCCPTEDWVAVGMENNNVEVLHMNRQEKYVLDDHQSCVLSLKFAHSGKWFVSTGKDNVVNCWRTPYGYRLLRSRENGSVLSCDISSDDRFLLTGSGDKKASLYELSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRN3</accession>
    <name>A0A914GRN3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRN3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10766.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10766.t1"/>
        <property type="gene ID" value="Gr19_v10_g10766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10766.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18466" checksum="2E008C617388A17E" modified="2023-02-22" version="1">MSKNGRQKMFLRDSLVGWLGEFVALNKTPDCRLTSASQQFLNEAILEERQRTAESPRHLRSVSTQTAVLRLRQRLRCHNANERVAAGDDDTAGAATVCHARHVSLPCGGQTPQVTSSPRLRRLLPQRFRRGGRSAESEKTPEAFVRSKKAAISELDENDDAATANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRW3</accession>
    <name>A0A914GRW3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRW3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10189.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10189.t1"/>
        <property type="gene ID" value="Gr19_v10_g10189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF132">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037617136" evidence="3">
        <location>
            <begin position="24"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="221"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10189.t1"/>
        </source>
    </evidence>
    <sequence length="440" mass="48711" checksum="938E4A85B6DCB5F2" modified="2023-02-22" version="1">MFLCNYFALIFVFGVHLFNRVNGNKTIELANADPPTIYITLFGKCPSFTLSYKSALFGGNERLSWKVARRFRFDKMFSGQSKESGQNAREIQISISDSKIMVGDESFSINRTKVRGAEPTYFDLNLNQISEKTLMIGGAEKEPLKFGQQFFEQLKLGPFLSDFAGLWLLGVDIVPRLGQMPTKITPLALTKCKLLAVKQRPKNCVSFNTTNAHYLAGNPLITGGNQIDIGIMPWTVRLGFEKLIENKLKRGTCSGSLISPEFVLTAAHCFLHLAEGEKYKMVFNSNTSEIARNDSKGFEIPITRQSNLNLFVHHKFDSKNIIGRFDLALIKLEKPICGPIYPICIYCGLVTKFRHGSAIIAGWGKTHPNGTLSNELIGRFVQLTDCEGVQNKSIKICIGEYNTTQKGDSGSALLASNGTNFVQIGVLSGKPGNYFGTNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT46</accession>
    <name>A0A914GT46_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Gem-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the core SMN complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GT46"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10503.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10503.t1"/>
        <property type="gene ID" value="Gr19_v10_g10503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017364">
        <property type="entry name" value="GEMIN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038038">
        <property type="entry name" value="SMN_Gemin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10503.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27166" checksum="8D04948FCB7E178C" modified="2023-02-22" version="1">MEQEAFYTVGEFDRSRVDLNKPAMTVEEYMQQVVAGRELLPDVAVAPAEVLKRVSATSSKMYNVPGMRENSHTFTNRFGPNKEWCVTKSNEFSRSRSVIESIKVPDDPLKDIKLPPVSDSMRWCQCFAHHKGTPPTVALTTSLNDNQVNELIIHQVNYMLSKGQTRATLQWLYALLLVVKKPLLHEVCSSLRDFCRKCKEWRSELDEDEEETNYQLSFFISIISIYFAQRDLADHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTL1</accession>
    <name>A0A914GTL1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTL1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11141.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11141.t1"/>
        <property type="gene ID" value="Gr19_v10_g11141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11141.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16955" checksum="CAFDA4CFA6B6713D" modified="2023-02-22" version="1">MIPSLGVYAVGDGVGVTTLAAKWPTNSSELAALGPAETGAFETASRVTRGLFPEPVTPPPTGRRSRVCGVLPAFFYSTFGHFLSSWVRHWDFRPFDTGTFDHSTLGLSTIRHWDFRPFDTGTFDHSTLGLSPIRHSTIRHWDFRPFDTGTFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUN2</accession>
    <name>A0A914GUN2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">ATP-citrate synthase</fullName>
            <ecNumber evidence="19">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Citrate cleavage enzyme</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5 19">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A914GUN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11356.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11356.t1"/>
        <property type="gene ID" value="Gr19_v10_g11356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014608">
        <property type="entry name" value="ATP-citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036511">
        <property type="entry name" value="ATP_citrt_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="25">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="24">
        <location>
            <begin position="253"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="23">
        <location>
            <begin position="499"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="22">
        <location>
            <begin position="645"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="450"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="20">
        <location>
            <position position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR036511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR036511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11356.t1"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120487" checksum="AC49BD73907A0879" modified="2023-02-22" version="1">MSAKAVNEYSGKELLYRSLNHVQALVKPKAVQLDEHSNFDEAILNCEWINKEGQGVLKPDQLIKRRGKHGLVKIGSTDELAKWFNDKKGKNVQIGKTTGRLSKFILEPLCKHDAKDELYVAIYSKMNEDLILFYEEGGVEVGDIDAKARHLIVPVQLKDEEMELSNQSIDQLIGNNVEESKKSLVKQFVRELYDVYKKNHFTYLEINPLVVRDGRIYILDLAAKLDETAAFLCSENWKTRFGHEVEFPAPFGRDLTSEEKYIADLDAKTGASLKLTVLNRKGRVWTMVAGGGASVVFTDTVCDLGGASELANYGEYSGDPNETQTFEYAKTILTIMTEGEPHPKGKVLIIGGSIANFTNVSATFKGIIRAIEMFAEKLRQHKVTIYVRRGGPNYQGGLRKFKEASTKLNLPIHVFGPETHMTSIVGAALGVRPLPEASLTPHTTGQFLLAPERGSSGAVGREESTQVANGYPPKNNEKKAKSEAGEKPSNAAVKSLFERDTKAIIWGQQQRAIQGMLDFDYVCKRDAPSVKEMLIPAYKSMETAFKSHPEASVMVTFASMRSVFQTVLEALDYPQIKVIAIIAEGVPENQTRKLIKMARQKGVTIIGPATVGGIKPGCFKIGNTGGMMDNILASKLYRAGSVAYVSRSGGMSNELNNIISHNTDGVFEGIAIGGDRYPGSSYTDHILRCQDDPRVKMMVLLGELGGEEEYKIVQALKEKRISKPLIAWCIGTCADHITSEVQFGHAGASANAVRETAAYKNAALKAVGAHVPDSFDDFGVVISKVYKQLVENGSIVPRSEEPPPPVPMDYAWAKELGLIRKPASFMTSICDERGEELLYAGVPITRVLEDNVGVGGVLGLLWFQKRLPEYANRFFEICLMLTADHGPAVSGAHNTIVCARAGKDLISSLVSGLLTIGDRFGGALDGAAKSFSEALDAGLSPMQFVNEQKRLGKLIPGIGHRVKSINNPDKRVEILKEIAKNKAFFKQETPLFDYALKVEQITTSKKPNLILNVDGAIATIFVDILRHSGMFTPQEARETIEIGALNGLFVLGRSLGFIGHYLDQRRLKQPLYRHPWDDISYIMPEHEFAEQPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVB8</accession>
    <name>A0A914GVB8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEC14-like protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVB8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11125.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11125.t1"/>
        <property type="gene ID" value="Gr19_v10_g11125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058960">
        <property type="entry name" value="Ctg-1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25883">
        <property type="entry name" value="F28H7_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="112"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="303"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11125.t1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48557" checksum="14FA82937A2668A5" modified="2023-02-22" version="1">MPKSKIQSASILAEQQKSGFPCQPPNLDELEDISTSSQQNWCRPISESELSQINDLRQILEPKLTTQEVDKTYLLRWLRSKDGKFDEAADGIRKDLVFRKAWGLDKIENWNAPEILEKYCGYGFLSDHDGNPILMSLLGNMDVEGMLRSVQSKDYIKFSLAAIEKGIALCRERAIQTGRPFEQMMLVFDLDHISSAHYSSKQFASSFTTLVLLFQEHYPLVLRKILVIRAPEMGRIAFNSMTPFLSESIQSMIEMPSEEGWQSALSNYVNLDAWPVHWGGRMLDSNGDPKCPSKIRYGLGPVPDSYFVDQSRAMPDYDQLTTVYAGDKHLIELKVKANTRIGWQYLTEEEDIGFAVYFDSSGNANNLTEMDCVFPYIRLECSQVPISGSLLTEQPGRYIIEFDNYYSWFSAKQLRYNIEIDDRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVE1</accession>
    <name>A0A914GVE1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVE1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10747.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10747.t1"/>
        <property type="gene ID" value="Gr19_v10_g10747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF11">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038078926" evidence="3">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10747.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36313" checksum="46365AFF78015A33" modified="2023-02-22" version="1">MCRRLLLLLFLLFCLQFSSILARADDEDAAEAEKTNKIEPEGPNNEAETDAFKDPSGGFGTDIDWVPWPQAVSVALDLNRPIFLLVHKSWCGACQALKKSFATSSKRKELLELSNKFVMSNTDDEDEPEDEEYAPDGRYIPRLFILDKYGKRYPVDNKKNFPSNIAYFPQVPDVIRAMKMGLELFEKEQSGEKTEEGESDQKTEKKKTGAESAEKKSAKSGGKTKDAVPKADEDVGKGGCPHAAGKAAAKAKKEEEEAKKQKKGAEKKKEEEKKQKAEKKNKEKKEGTEKNNKEKKESAEKKTDTKKAEQQKKKKGGEKGKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVY9</accession>
    <name>A0A914GVY9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="Gr19_v10_g11691"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="561"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
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            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
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            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
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            <begin position="262"/>
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    </feature>
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            <begin position="294"/>
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            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
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            <begin position="332"/>
            <end position="354"/>
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            <begin position="367"/>
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            <end position="420"/>
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    </feature>
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        <location>
            <begin position="431"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11691.t1"/>
        </source>
    </evidence>
    <sequence length="639" mass="71646" checksum="88259855799F942E" modified="2023-02-22" version="1">MAGGNSERGEGRITFSLRPWGRRRVGLLWKCIGRRRREEEEKKKKNGEIRDRAKRRSAAAVDGDVASLSEKNRGERRRRWERRTVCCCCEVEMMGGHRAATNDKSFTSSNRHLEEDKEKFFGMGKRKLSQTAHNVNPAQKRWKKDFDHKKAKGKKGAAPAVHAKGQQQQKPRQLPTAFQKKKEKEALKFESESDEDEELTGEEMEDESESDEGEVLPQTKAINKKGAAPAVQAKAQQPQKKGQLVTAVQTKKAKETLKFETESDEDEELTDEEMEDESDSDEGEVLPQTKANNKKSAAPAMQAKAQQPQKKGQLVTAVQTKKTKETLKFESESDEDEELTDEEMEDESDSDEGEVLPQTKAKDKKVAPVVAKAQQPQNQLATAVQKKKEKEALKFESESDEDEELTDEEMEDEDESDEGEVLQQTKDKKGAAPVVQAKAQQQQKQRDAAAATNAIVAEEDRRRAERDKVTIFLRCEALQKMTEHEIKSLHPDTLSVRTNNKGYCWLLFASEPTAEKALAALSKKTAISGKELYVDRCGAKAQSKSEKLKKGKALDQPINPTELIISNFPLATTTEQLKVIFPTAKSVRLVTLNAKKNNFRRATRALIDFGNEADAKKAFDKGAQIKVGGAPVDLYFARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXA3</accession>
    <name>A0A914GXA3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914GXA3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1202.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1202.t1"/>
        <property type="gene ID" value="Gr19_v10_g1202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029491">
        <property type="entry name" value="Helicase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14493">
        <property type="entry name" value="HTH_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="102"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="298"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="13">
        <location>
            <begin position="680"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="896"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1202.t1"/>
        </source>
    </evidence>
    <sequence length="936" mass="105377" checksum="FA2AC36FBDC90F75" modified="2023-02-22" version="1">MSFSVAINDDFYDESQDHLYLINEDENALNETLTFEDSESENTETVSNGICTASSPNPTPSSSALLSSEGHSFAAVLTERSLEILKKYFGYSRFRPLQCEVIDAALRSRDQLVVLSTGYGKSVCYQLPSLIRNNLTLVVSPLISLMEDQVNALEQAGVDAAYFGGNQTRESIFDSIKRGRLRILYITPEAYQSTPDFIRKIHEYVGLLAVDEAHCISQWGHEFRPGYRQIADIRNVLVGVPVMALTATATAPVRNDIIQNLRLNNPKVTMSGFDRKNLFIEVQKRTQALSFEKCVQNDLERLLEDDPKHGPNFGGPTIIYCQSRESVNKLTQQLRSIGVRAVGYHAGMTTPQRHKAHKDFATDRASTCVATIAFGMGIDKKDVRRVIHYGAPGNIEGYYQEIGRAGRDGFPSRCNIFYSSSDIMIQKNRIMKNNLSRDYEHHKLEMLRRMEQFLTTMSCRRYLILSYFDNSIQHPDAPNSDCCDNCAKRCQLGGKDSKSYGKQPMVDFGEEAKKLFNALELFNGRSGLRKPIDFLRGNENKIPIALRKSKGPLGQELFGSGKNKTDTWWTEFGKLLRNNGFLLESKSTFAQYGYLTQLAPKATEWLSRDSKQLELIPNEYLLSSFNVKTAVEHRGAPNRAAVVQVYSEKKLNESKERTYKDGTYYHSPISTSTSSCIETYEKLPELRKELENFRYELSLQMDCAANSVFSNTVVEELLRIRPTKEQSLAIVEGLPEQRRHQFAKQILCLVANFCASNGVPTDQTGSAGGEVPLELEGTIREQLSPSERTTFLAHFLGRLSLVELASRFKLTSGTIVNHLNSAVRKGLPVHLDVLLISPNMVSTVYQKVEENRRDIIRMKPIMELLPENLLSYDQLRIILSIFEFEYGIKAESGADEPPLFKRKSSSWTAQSGETGGGGADDVVYNVKKKKHSLFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ82</accession>
    <name>A0A914GZ82_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ82"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12150.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12150.t1"/>
        <property type="gene ID" value="Gr19_v10_g12150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000748">
        <property type="entry name" value="RNA Binding Motif protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12150.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9235" checksum="3A697EDA75C6E4F3" modified="2023-02-22" version="1">MASSGFSVYVGNIPYNATEEDIGNMFSSCGVVTNVRIVYDRETNRPKGFGFCEFQDQQSAQNAVTNMNGAELHGRPLRVNLANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZY2</accession>
    <name>A0A914GZY2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZY2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12661.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12661.t1"/>
        <property type="gene ID" value="Gr19_v10_g12661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12661.t1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41725" checksum="AC0DF463A267A895" modified="2023-02-22" version="1">MSDNPKKVEKQLQKIFICADVLFEVFKFCGPFVLGLKVALISDRFDLLVDAHFKLKEWSLGNLEIRRAKKGKGAEIVKYIDFKVSRLPIPQESLPANVIGFERLTISYIDQSVIEFLELIRPLFNSEEMHLTIGTFSFGSRSWKIIWKNIWPMIKDNICGFDLEFFNLDCLRRLSPTVLGDCQKLQMIESFDLSPAFPADDSAGASSEQAVAKWLHTPRGDGLPKVLKCVCCLEEVEGLKMAFDNSTDAVNFIIFLYHSDNIVPFELQNNSTGERLELQRFKESDWLLVRCPIERDEAKWAEWENETADRNWCPWNRISIRLNANSIGDELLDTNEGPSKPREKEGFFAGQMKRLKKFIWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0S4</accession>
    <name>A0A914H0S4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neuralized</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0S4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13114.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13114.t1"/>
        <property type="gene ID" value="Gr19_v10_g13114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16647">
        <property type="entry name" value="mRING-HC-C3HC5_NEU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000005">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase NEURL1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF6">
        <property type="entry name" value="PROTEIN NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NHR" evidence="8">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="8">
        <location>
            <begin position="253"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="674"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="495"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13114.t1"/>
        </source>
    </evidence>
    <sequence length="725" mass="77802" checksum="2F2014560DDD0036" modified="2023-02-22" version="1">MGNSAATARSAGDPQSTLTPGEAFSDYNENIINRGTLGRPKPLLKFHSVCGTNIQLLREGNRPISIDEIVCIRLSEVGTNWSGVMRFGVTNVDPASFRDIELPKFACPDLTSKGGYWAKSLAERYSVEGSILHFFTNESGEIGINVINPLWIIVDIYGNSIAVEFIDPNEVQLQSKRISSKNRTGTTLSARNASQPLSSESAESSPAPMSLSTYHQSIASMTASNSANNLLNVTANSPRSSSSRASPMANASKKRFHNVKGVNVYLQHDETVAVRKHGEYYQGYVFTERPINVGDKLVILVSQVEDAFSGSLAFGLTSCDPIKVPASRLPVDSDELLERPEYWVCIKDVAAMPQVGDKLSFQVDAGGRVIFSKNDAPSRVIMHVDTSIPLWAFFDLYGSTRKIQLLDIDTSLSTRNIADLSRSYRASSEGACVNVCADRSSVVVDIKPRPNRPSSTNWNTDSLRVALPVGSSSTHHGHSSAIAIQSESAVLSNASISAGPSGAGATSSSAPSSTTPPFSSHPMESTELAQIRANIAMRRRNRADASNGGVGGQTSTLSSAFLPDTSQPNTSNSNSSGIAANGDSVLNRSPPTLNELLASRRIQLEARMAALAAIRDNQSPIRDDVSTDSSPAGRNEAAESAQQQNKSPVGRNEAAESAQQQNTANGEEQPGNECSICMSNQVNAVIYRCGHMCMCFSCAKETHRRSGDCPICRTPIIDVIRCYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0V9</accession>
    <name>A0A914H0V9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0V9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1300.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1300.t2"/>
        <property type="gene ID" value="Gr19_v10_g1300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1300.t2"/>
        </source>
    </evidence>
    <sequence length="216" mass="23284" checksum="D1B0D0D92F82946C" modified="2023-02-22" version="1">MPTILLEVCVDDADGLWAAIQGGADRIELCSALELGGLTPTSGLIDVARSVNKSVPIFAMIRPRSGNFSYSDREFESMCKDIECVAEAGLAGIAFGANHSDGTLDRHRLQILVKLAKPHFRNEMKTFAKKGYGLGTTLHRSFDLVPNIDDAIKTAAVELGIDRILTSGRSAKAIPDGLEDIAKTVQISVDNGIRVMAGAGIRAENVAKFCRNNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0X2</accession>
    <name>A0A914H0X2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor AP-2 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0X2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13142.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13142.t2"/>
        <property type="gene ID" value="Gr19_v10_g13142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="362"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13142.t2"/>
        </source>
    </evidence>
    <sequence length="603" mass="65851" checksum="8E454F18FC9D6F0A" modified="2023-02-22" version="1">MYNNAHHNSSTPGDIPSQQQLQQRYWKIQNGGGSILAGGQQPFRGVTHPMLSLADQPPPFHRRTVEGAPPIKRAHRDEDSAGGVGEGREGTAEGEKENQQPKAKRLHLPESDGEVDEEEEEEESSRSTNSSAENEESVNCCFSSSALHQQQSQSHHTANLMVTPHQRSQASSASIGNPLAHSTPYLGALSLNSFQQPLDYWAMSPPHLALVAANKNIIARGAFVSNPSLGQLTSSPAYYSNFYGQQHQNLMAAQVGGGMASGAGNSFSLQTQGYAPILQQNLSVNSTYQSRDSGVGSVKVELKEDGKNETGSSTSGGSDESGSSAIGRDLVGMSEAKFPPFFETITVDGQKTPRDLESIQFGMVPPRLALLNCNKKYPITLAEIFRRLNSPEFLNTSYLSGILRKAKNTNAGKELRNHLNSYGCGIDLRTGRRKQSSVTTFTTLCEREAIQMADDFNKLASESFPHQQIAQEMNRRADAKSSNVVQRLLDVRNTSQILCEAIQILQQGIEDETLPFPSANQQVALVEPADQSLLLPTTVYGIKNFSRLSHCFGNRTVMVAWGTLLNVFQKWEQSLDETLKNVVGLPGTSNNDPQQSVKRNYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H154</accession>
    <name>A0A914H154_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H154"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1229.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1229.t1"/>
        <property type="gene ID" value="Gr19_v10_g1229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF4">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1229.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="30417" checksum="9EE5A326B9EE1855" modified="2023-02-22" version="1">MLASVVRIPPPYPTTVGGFSGAECCRCLFRVFVRRCLTFSAPNYRLNDVSAHKNHYETLGVERSASPKNIKAAFFELTKKHHPDMNPEDKVKAAEAFQNITEAYEVLGSEEKRQIYDCPHGKKTTFARFGTAEKQKDWTDLDIDFKDFEHFQQENRRRRMFHDWRRADTTSDFFWHSHQTSKMYKDPRVLEREVLEKRLHAELTERRNRDKMPIPTFEQLYRLEILEKQKRSRKQIKNYVVILPIAFLVFFLYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1G8</accession>
    <name>A0A914H1G8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1G8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1236.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1236.t1"/>
        <property type="gene ID" value="Gr19_v10_g1236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1236.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="44505" checksum="0613D27C2BBFB7D7" modified="2023-02-22" version="1">MKKSSSRLRTSLKRVPSNSAKFFDGQQKLLGRRTHPLGAKLPISRQIYCWARPPGFVGPIAVRRIGPLFGRRLFRQKKQVQVSSLQDAFDSLAEPIDGLETEARLMAALSQLEHIGVVKSVTKMSTNSATTASTDNEISLLETADVRADDGVVDDRLTISSLSSSLVSSTATTDTEDGGDGVVEGRKRKKKGVDGSSGRAGSVKDVEEMDGEGLLLAEAAASGSDKDNDALCETKTRNQAIARLITFSCILFTVPLTLMYLTYRFLFIGHFHLAHDRAILYAGIVAAATVYLILAVFAWVAYRDESELANQMTASAVMEEIIPNLRDPLVKSRMKSLFAYSFLILFVPLGSMFLLKNFLFETLLGYQKRDSMLYSAIAAVVLVHVVLIIWIRTAWDEGKPAEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H383</accession>
    <name>A0A914H383_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H383"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13740.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13740.t1"/>
        <property type="gene ID" value="Gr19_v10_g13740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037770827" evidence="1">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13740.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23079" checksum="01C9818D8D921D38" modified="2023-02-22" version="1">MQLNPKLLLLILTPIVCSFPVEVIENGIPEVNSNPVEVIENGIPEVNSNPVEVIENGTGTPEFHSNPVDGTPDVHSNPVDGIQEKDIIEKFLTLLELEAIVKQFIKASTKVLLNSNDGKNELDDLKTAEELYQKLVSLTETLGLENLSMFEAAKYFVDDFPHKSAVFKPAKDFRKIEVRGIPKLYAKNFRKIEHRFNKLEASRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H386</accession>
    <name>A0A914H386_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914H386"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12851.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12851.t1"/>
        <property type="gene ID" value="Gr19_v10_g12851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12851.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27878" checksum="A767D03D52520969" modified="2023-02-22" version="1">MPRPLTEEFSVRRRRAKVIWRNLRRQKPAAVCFDMDSTLIQEETLDEYTRFFGLDLSGSAITRQAMNGQLSFRQALLHRLELLRPTKAQFEQFVSEFSPKLTEGVLELVTVLRKYGIDLFIVTGGFVEVAQRVAQRLNIPVQNAFANRILFDAEGLYEGVDKSQLTSQSGPAPVGKAGVCQLLKERHCYKLLVMIGDGGTDMEARPPADLFIGFGGNQVREKVRQGSDWFVREFRTLTNVLEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4F3</accession>
    <name>A0A914H4F3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aromatic-L-amino-acid decarboxylase</fullName>
            <ecNumber evidence="8">4.1.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DOPA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.28" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914H4F3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13152.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13152.t1"/>
        <property type="gene ID" value="Gr19_v10_g13152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042423">
        <property type="term" value="P:catecholamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042427">
        <property type="term" value="P:serotonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF167">
        <property type="entry name" value="AROMATIC-L-AMINO-ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13152.t1"/>
        </source>
    </evidence>
    <sequence length="586" mass="65909" checksum="DE05628E3CC78559" modified="2023-02-22" version="1">MRKNPWACKALLKFPQRIIYEFPAGVSGLCRHDASSFFRYPMDSDSLRRYGCEMVHFVANYWDSLDNGDRMPLPDVKPGYIRALIPDEPPKTAEEWEKIFADIEPVVLRGNTHWHHPNFFAYYSTACSYAGVIGDILSGGIAAIGFTWKSSPAMTELEQSMLDWLAKAIGLPSAFWNSDPGPGIGMIQSTASDATLVALLSARARAVETMKRNSSSVAIPQVLRDPIVKAMSRLNGMGETLRNRIRTNGNALTRMFGVAIKGEENYEGKIGQLTTFEAHDPVYFSRLVAYCSDQSHSSVLKGIMLCGVKVRKLPTSKENGGNFVLKSEVLESAIKEDRAKGLTPFILVATIGTTNTCAIESCRELGPVCSREGIWLHVDAAYAGSFLICEEFRYLSDGVEFADSFNFNAHKALMINFDCSPMWFKNGDEAIAFFNVDPVYLQHEHQRDAYDFRHLQVALGRRFRALKIWFVFRAIGIQQIQQFLRMQNGLAKTFADLLLRDDRFELFVPQNLGLCCFRMKTSNKLNEALCVAINEDRRVHLVASSTHGTFFLRFAVCSSKTRETNIEMAVKVIVEMANKVIENRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4F6</accession>
    <name>A0A914H4F6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4F6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13751.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13751.t2"/>
        <property type="gene ID" value="Gr19_v10_g13751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13751.t2"/>
        </source>
    </evidence>
    <sequence length="108" mass="11238" checksum="7BE1E3CDB925719D" modified="2023-02-22" version="1">MLPQFAVRKRRAYNSAVDNSALDNSAVGQLGTRQLGSEDNSALDNSACELSSAELSSLPSCLVPSCPTAELSSAELSTADSSVLAEILGSSALNRQALNRPSADPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H540</accession>
    <name>A0A914H540_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H540"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14072.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14072.t1"/>
        <property type="gene ID" value="Gr19_v10_g14072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF1">
        <property type="entry name" value="DEGENERIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14072.t1"/>
        </source>
    </evidence>
    <sequence length="506" mass="59586" checksum="19D149F300BBA31D" modified="2023-02-22" version="1">MNQQQQQQQQQQQQQRRKSELIRKTLSEEYPGLDYLGFHNVLNAKHFWYRVLWFSVVTVCLLIGLLTIFRIITEYTQNPSATLINVKSAEKLLLPQLTVCPTNAATINIEKMEQKLFKNNSHFVKYSTDDVLNFAYFLLAGSGFQKMYWKQFEEMKKMQLNGFYAILRNDSSVDQFFDYFFDEFGLRCDEFFHFCQLGDTIMNCCEIFVPIYLIRRGRCFRSIELYQQNFDELGKLRVQLRHPHQMDPKMSTQEEIMAFIAEYKPQLAPFPRYYLYPGIWTKMRLNAKHISLFPAKEVCSQEYERLGKDTCYVENWLQTHVEVPLNCTFPYVQEIRKDKALKSCEPLQLIDNYDSAVQTTNYTIHSCVLACDRWEYMVSLEKIDMSRVYKNASEFQFAYRIDLSYNDLQYELIEEVSTLTFVGLIAQIGGQMSLFMGSSILNLIQASIMAILLLYRTLQQNRRQVQDISVEASAQNRHLGSELPMTEVTRHNADETTITMEHNLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5H1</accession>
    <name>A0A914H5H1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-Fucosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5H1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14001.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14001.t1"/>
        <property type="gene ID" value="Gr19_v10_g14001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052501">
        <property type="entry name" value="Alpha-1-2_FucT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22898:SF3">
        <property type="entry name" value="ALPHA-1,2-FUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22898">
        <property type="entry name" value="UNCHARACTERIZED GLYCOSOL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037714229" evidence="3">
        <location>
            <begin position="20"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14001.t1"/>
        </source>
    </evidence>
    <sequence length="544" mass="63063" checksum="B42086FD21C3D415" modified="2023-02-22" version="1">MRFLFIFVIFINCPPLNDQHATKSILLTDGHNGKKIIPFYAVAQCSALNWNGKSPKTFGLAFRLPRNGAGRCDDGILICYPKTLTRNYFTGIGSASFWSRSFKVKRTFQVVNEKNNTVSQKCEAFLEKNGITNGKHWRGIYVYTKSLNDRKTNPTRQIILETSLTPRVYNFGSNTRQLAIHFGLRGNRYTTVTNEGKPYLTDEFNRNNPYSKHLSKGAFLEEYTGLWLLGMDMLPSMDMNNVTVFIERSCSCTMEAWFTYPTDSIFPMNLSKMCKRNVTPEEYESGVWLPYMELESLLDESQFLQKNKNAQIKYIKANETENETFFVKSFAPGCCTYKDPQKAFSMIKEKYIKVMGNYFQSYKFFEKQRTEIRQIFQFGEEICKTVDTYQREFFDDDHTHKFCVHVRLGDFEKTGIESKNDFTELGIEFGFKYLKKKFDNISVVLLGAEKQFLMDLKIDRQLISNVFLPKAMSRGEDLAFAATACDSLLITASSSTFSWWIAYLMPDQSTFFYNSNFNGTKYSRENFLPDWIPIQLINGTMMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5P0</accession>
    <name>A0A914H5P0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5P0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13907.t3">
        <property type="protein sequence ID" value="Gr19_v10_g13907.t3"/>
        <property type="gene ID" value="Gr19_v10_g13907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13907.t3"/>
        </source>
    </evidence>
    <sequence length="457" mass="49283" checksum="FECCF6588D077390" modified="2023-02-22" version="1">MVKHKVKTLPNSVFIKMDKTADDGSSSVFSRTIWASDRRHIAGTEIGAFLLLDGFGDDPAAITQFVADTLLKELLDSPTLAAIVSQIAKSGERWAWSQCQTFNHTGVIEIQIKRSPQIDQFISDTFHHVDSSAYDALFGNLLAGEARSGQNDEQRQQLSLMNSGCSAILALILGRQLVLANCGNSLGLFCLDSSDGLLTAVRVSELHEGSSTATATEAGGAAAVPFRCFGAFAHKTGGLKGMAAAATAAAVSVRPTIQRPIELYHSARFLLFVTAPLWRLIQRHFCKENDQSLDIALANFVAGAECHKEEGNWAQHIQSAIAKVLSGCAGEEMSSSLALAIVDFAKTDFDRGEEGQHENDCCSSTNVSNSVPSEVDWSEFNTHHLREENRRGAANGTTCVPFLSAADDRSFTFSFTAHKHFHQSSAGLGVREGSSTVRKCPSANVRPQMSHRDPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5X8</accession>
    <name>A0A914H5X8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5X8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14482.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14482.t1"/>
        <property type="gene ID" value="Gr19_v10_g14482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037800753" evidence="2">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14482.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25902" checksum="2459062358F94DEA" modified="2023-02-22" version="1">MSTFLFLAAICLFVAASILLETDASPKNKKLKKGSSSSGKAQSTPVPKANSSAGGIKHLLPAMSECTLSWTTDSADVHFLVGDEKEPLPAHKAILANAKAAAAGTGSSEEITPVKASHVFGHSFGFEVRKCWTSKKSFWGNFTVIWNSVYPSNALGGFQFIRNTLAPLVKEHGLENVPFSPKVQLRAPLEWTGKIRRVNKDARTRHKRIRDGEKWRTMLIPGVEMGKEITPQKLCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H698</accession>
    <name>A0A914H698_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g14394.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14394.t1"/>
        <property type="gene ID" value="Gr19_v10_g14394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14394.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26188" checksum="1794760BFD807E35" modified="2023-02-22" version="1">MPKPNSVVGRIKHLLDTGNGADVRFLVGGGDEKELLPAHKTILMAASDVFEAMFPFDARNADSSEEIKPVEVPDVEVGAFKAMLSFIYADDLSGLNGDNAIAVLYAAKKYNLPEVVNLCLNFPISKLSNVFFAFAQTRFLGEEVNCNLECRTSLGGQKMPSKWERAFGGKQTRNSRPGTFQNSFSAYPSKGFYCEYCSVRSVGSXDPVQGDHGVAPNVFSRNWSVELGFHKCCQPNAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6W2</accession>
    <name>A0A914H6W2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6W2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14245.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14245.t1"/>
        <property type="gene ID" value="Gr19_v10_g14245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037802660" evidence="2">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14245.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="36551" checksum="E8FEEA2A4785E197" modified="2023-02-22" version="1">MFFLTIISLFICINVAETALNLSEVEMLDKSIPKERTIKIRGNVTYIKRSGDSNVSHQSLPIFWPQTGLQSLPFDHDRSVVNHRFTNIPSSPFYPVEPAAQNGGPPSMFNAAYPIGPPPQPMPPAYATFPQPPSTGPTTSCECCCCPSAASRNCPCLQNCHPPCCGVTQTTTPTPTTTTAKTTTEKTTTIDPRETTTTTTEKTPTTIPTTLSSTTTNPHRNPPSCCPPMIINCPNNRAPCFMNGGGCSTGPCIFPPFIDGTGGYPVGLPTYPGGYPAVPSFPGVPMPNYAPGGGHYPTVPESPGIYPIMVKLQRQKKMKYLKQTFDVTAPHRTLVSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7R1</accession>
    <name>A0A914H7R1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7R1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1459.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1459.t1"/>
        <property type="gene ID" value="Gr19_v10_g1459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1459.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8728" checksum="0CA0B690CD522581" modified="2023-02-22" version="1">MFFDPFTELAFLIFPQRLALNRPSPEGGKAKPVAWEVGAQLASRAGGKKGNELKVNELVRNESTAVHTNRDTERTPTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7T0</accession>
    <name>A0A914H7T0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7T0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14013.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14013.t1"/>
        <property type="gene ID" value="Gr19_v10_g14013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14013.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34656" checksum="F51EBCC1805A7CF6" modified="2023-02-22" version="1">MMPGEETVYKSIDRAEDETRQRADEYLDEYLNALNPSGYLKCAPPSDQTNKRHVLERMGRNVCRMPIQTKLTYEYSYGISDDDYGDDEVDAIIDDSADGNEVKNECVNFKGNVLCDGAKEMVVEIFCRQTDDKIDFFTDAEGNFKIVMSMNLKASFYKCTTGLIIGFYKNQPTKTRLRLTNLLKSPKKKAEQKKRLLKCFVSVRFKRLKFGTKQFVDEATNQAPQIDDVSEEEEAKNEFCVEFGTGGKATINGQTYTCSDSHVDRNFDLYSKYFDGTNEEDQSSEDSKRQNEEQSSSSTSGTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H876</accession>
    <name>A0A914H876_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H876"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14628.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14628.t1"/>
        <property type="gene ID" value="Gr19_v10_g14628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="56"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14628.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="50932" checksum="3872367DE43E985F" modified="2023-02-22" version="1">MRRPGLSLNQMGQIRAHQQLLQQAAQMRNQIQQRPSSPFEGDAQFFGVLNRIVGPITRETLLSLHRIVMAGGRLQEKSVERLVAQFCNELNNALAAVAAREEEATTVAAWRIHVALHPFHDGKGRTSRLLMNLVLTRAGLAPLILPSESRARYNELLRASHYGRLVEFLWFITFQHQSRVNMELFSNRLGSKSLMISDYPENPNLCYTWTCAGKKSEDGQQRYVCTGCRRIRDKKEVPSDAKLPARKATESGWMDEGSKYAHFCQPIQRTKILGIEERRKVQAELALGSRENTASAKVRIECRVAQKYSDKPQDERTKIRDHACVSHADEENAVAIDEGRQPPPRPFALTEEIDGDIAYQKQHITNFLNTDFDEDQFHEAMTQYYGRIGRLIGFNPVRRAEVEEIMMDESARELAEASLDENGLLAALSDAEDVENVAPQFDEEVDVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8F7</accession>
    <name>A0A914H8F7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8F7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1470.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1470.t1"/>
        <property type="gene ID" value="Gr19_v10_g1470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1470.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27259" checksum="EA32DC3B49C275B0" modified="2023-02-22" version="1">MKTFIFIFYIQTLYEVACIGSKLTLEISPSLYDHNVFSYVVEVECVDLNDKTFPYRDDGTKTVEMIIFPFENRVCKQFTISIKVFQWQLENGAVAHSPPRVGLIPRSGPTLAYIEMPAIYGSMERKIDLGKYFTLNITPTIQGDAFYDVKVYCKENMESTNQSTVTAKKCSKTGCSAIFFFKRDLCSANEYKIFLWKWKNNLAKESLIKQKPAREYSKLFIVDGQEQLLHYDLADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9C5</accession>
    <name>A0A914H9C5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lethal giant larvae homologue 2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g15.t3">
        <property type="protein sequence ID" value="Gr19_v10_g15.t3"/>
        <property type="gene ID" value="Gr19_v10_g15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="7">
        <location>
            <begin position="394"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1076"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1136"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1287"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1535"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1095"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1136"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1295"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1544"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15.t3"/>
        </source>
    </evidence>
    <sequence length="1611" mass="175564" checksum="CA25AE05846628A1" modified="2023-02-22" version="1">MPPHLILGSATTGSAHSTHTNILRVENWLRKKPFGGKHIDEVWLFDTHIPRLFLETSCASNQFVEQKSTSRTQRHMDRARRRLASAIDGIKAQFTDADSEDTADMPSTATAPPAGQQPMVRERVEPSHCRLSKIVRHGFPDAPKCMAFDPVQKLCAIGSGQGCIRLLGQAGVDQLLKHEPDEPVIHLQFLINEGGLVSALQDDTLHLWNFRQRIPEIVHSLRMSKERISTVYLPFQSRWLHVGTEKGNVYFVCLATFELSAYAIQWNKAIDLSCRTHPGAIKSLEVSPVDPTKLLIVFERGQLVLWNILTREVDRFCSDEQSSPVTAISWHFDGKQFMSGHQNGSLSIWNVKKPRELVQQSTPHAPSNDQQQQQEGQEAEEEDVQQHQQQLNTVTCKPITQLSWNVNADAEQLIIFAGGMPMDEGALPSVTVMRAKCSLTVLEMDHQIVSMLPLQASPYASAALHPIAMAVLLRNDLLVVDMQGQGYPCFEVPHPMDLHESPVTIIRYFSDCPVELIAALTLVGRNQRRQGVRLSERPWPINGGIGRECATGQQEMLLTGHEDGSIKFWQASSEQLQVMYKLKTGRHFEKTIAHIASTAVAHSGEEKPVQTPPHVSHAVADLELCSDSRQLLVASRSGQVTLFRFAKTECCQEIATVMLPQLCRTTVPTTFSPSTPPSPKDGASAGGDHSPRPRAGSQSRLKQQSRNSGSSGSVTGGGGGGRAELRRQPRTVVDASSTPAAPPGAAVASSSSRNSSHSTDTSLGSHYAEMTPLKVRGGVLRRPAGYQPELVCQIPWINGSRPERVTALALNSAHGLVALGTKVGLALVDAHTAAQIYAWSNEELLGREPIPFWSASLNSQVSEMAISPAVEQLQLTMASSSSLSTTNTPRKRHPLARALSIRSPCIKSSPSTPLNSPPIRRGSLLKKMVAIQTKLEAKFGSPKHADDDEQQRLVQAVHATGPQHASDQFWHHKKMAKKLHCRPSTPHGSETAADNVGTSLPITLVQRWQSFGTGRSTKKARLSRKHSAPEIVVVGSAAAPFERMQSDRSEDHLDSVDRHLLRSLGLLLSHPAQRQFSAQNAPKSPPPVPPAPQLSRHNTTDSATAAGQQSSTTEKFGASLNARLQRPQLVKAFTFNPTQSSSANGDGSPKEFGASPPQSAGIEPHNCNGNLSADSRASSSESLDKQKKAVSTANVEEDDEFVCSLQFINCAAKRKVPKLELCLWLGTSTGAVVAFQLQMPTNRIVSTVSVTPSGQIIRLRGRLLCCAFLDRSFCLLAGPTEQYKHQQMHAELSKDGSTTSAPQTAASGEQQQPLRPNKVITKASLSPVLSVTGTENPAAASEDAFQQLALFVSEFEVRAVQLPSYQQLFHRGSLDAEPMLKANCSHISGHPVLITLTSKGNLFVLSLPSLRTLLHVPLIGECVDMENLIFNRCDFSEHGLGIYAVTPTEVQKLTISAEIANQVNDCMGELFVPCDMPEAPKHHSFLRGILAAGASAVSGIRTGGPDPVAEMDALLREKPTTGVQSTMRTVARPLVTPQQQQQQLSGTELSTSRSVTAGQAAQQALQNLGERGERLNSTIDATDQLRNNAQAIQSRSAKLLEKYEKRKWYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9M7</accession>
    <name>A0A914H9M7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9M7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14549.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14549.t2"/>
        <property type="gene ID" value="Gr19_v10_g14549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14549.t2"/>
        </source>
    </evidence>
    <sequence length="133" mass="15148" checksum="7E29F8A6845AED2F" modified="2023-02-22" version="1">MSIALQNSTSNNASRHHHNIHNLLTNLPSLLLKLITCALINHSFVHLICLLLSLLPHQILIGNKKASTLYTCAAYNHELKEYKFSDNAFNFNITRRHDRNLHTVPPEQQWVNQSSPIALLGHVHKLHCFFSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA44</accession>
    <name>A0A914HA44_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="3 9">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914HA44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15624.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15624.t1"/>
        <property type="gene ID" value="Gr19_v10_g15624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="642"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15624.t1"/>
        </source>
    </evidence>
    <sequence length="680" mass="77694" checksum="3F77EA96D1ADB44A" modified="2023-02-22" version="1">MGASDPKVEERLHKIVVMSDSGRSSIVRKCSSSRLIRQFAETNITCNGEEYLDGGETAKLENRFVFECAWEVVNKVGGIYTVLRTKAPISTDELGGQYYMMGPYVEERVRLEVEVLEPETANLKYTLDQMYDWGFRVVYGRWLIDGYPKVLLFDIGSAAWKLDKWKHELWETCKIGVPFLDREANDCIIFGFLVAIFLKSFLDSSENFQPNVAAHFHEWQSGIGLIMCRIWKLNIATLFTTHATLLGRHLCASGADLYNNLATFDMDREAGRLQIYHRYCLERAAVNMAHVFTTVSEITGLEAEYLLKRKPDILTPNGLNVNKEKIHDFIRGHFYGHMNFDLDRTLYLFTAGRYEFFNKGGDLFIDALAKLNYMLKTTEDKRVKGVTVIAFIIYPASANSFNVDSLRGQAVCKQLRETIAKVKDSIASRMFDSCLRGRIPDMEELLLPAERVQLKRCILSSKRDTLPPICTHNMVDDANDQVLNAFRRCHLFNDEKDRVKVIFHPEFLSSVSPLIGLDYEDFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGSFIEKQVPDHDNYGMYIVDRKSRSPDESIQQLSSILYSYCTLSRRQRVIIRNRAERVSELLDWKTLGGLYLRMSERVAKMPRPLSATSTPAHSDEESDVESDTTAQEEHENLAWNEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC75</accession>
    <name>A0A914HC75_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein root UVB sensitive/RUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HC75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16174.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16174.t1"/>
        <property type="gene ID" value="Gr19_v10_g16174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16174.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26711" checksum="22450AAD6EC54805" modified="2023-02-22" version="1">MAIVRHQARRDNLADVAAKDGSQETLVNMLSLLVSLVLLPQVEARPATIWALFTFFTTVHLFANYRAVKCIQLETLNQKRLTLAVRFFAVHGTVPTIAECNRNEPVLGTLAIRRQLGCSLDALPAQIGAFVAKAISGRQTGHVTVDGFACKFSPSTVCVVAANGGRHANGGGWLAIADGAAESEIFNAVFELEFYAEERAWPNELVLSNFRHEMIARGWSLQVNQLDVDEWRYRRRQKWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCC9</accession>
    <name>A0A914HCC9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16054.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16054.t1"/>
        <property type="gene ID" value="Gr19_v10_g16054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056709">
        <property type="entry name" value="DUF7807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851:SF5">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25093">
        <property type="entry name" value="DUF7807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16054.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22805" checksum="E15C3DC7D9BF9E80" modified="2023-02-22" version="1">MIPIECNSSSSNNNPNIDVGIELEKATCCWGVFRTNAEQGALIVAFIGILFSLLGAFAFFMPFTDVYDPMMGVAGLLYVFPCLCVLLALRRRDPRLYLPYLIYGVIEMMFYLSVLFVSVLFMLNPPEDNVQQHLKDNPTKFTNADQARKDYRMSQGGEAAILLADVLVSLWFYYVIWTAYKVMRHRRSRGRVLLTEISTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD70</accession>
    <name>A0A914HD70_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginine and glutamate-rich protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD70"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15542.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15542.t1"/>
        <property type="gene ID" value="Gr19_v10_g15542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033371">
        <property type="entry name" value="ARGLU1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15346">
        <property type="entry name" value="ARGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15542.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26526" checksum="0AE8FFAC72457156" modified="2023-02-22" version="1">MPYSRSPTPPNRGRSHRSTRKRSHERSSERRHKSSRSSHKEKRRDRSRSASRPRNSAAAADSARIYAPSDVALELGGGNVNMARLDKKTVDWLQSKINEQVSSKISDIEEIVLERVKAAKVEMEKRMRQQIEAELAEEMEAIHRRERESQERCNAMERALEAKIRALEESEKKLSDERLEMLESKRRYEEERIELEKQRESVKKTEQQSILNKGGLMRDKIRLSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDA4</accession>
    <name>A0A914HDA4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDA4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1597.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1597.t1"/>
        <property type="gene ID" value="Gr19_v10_g1597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF477">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1597.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29939" checksum="9FE1D7A9CD6CBA4B" modified="2023-02-22" version="1">MLLDYLLSVRLHVYIFYASNTIFWSCGWGALAVGIWLYKQKSLYSVLAPTSYSAMSAAGLCVAIGAMILIISFIGCVSVWLKSKSLMISFFCFVSLLFLIQCMTGVMGFMYEGVVKERAKITLLHTINDTYYGDNPRATLLWNTWNQMQIELKCCGVDNFTDWFFYPRWKGRRFVPDSCCEVSKFEFLYLRGCAEPFTDWLLQHLRIVGMMALLFGIVELVVLSSSLRLLCNFHQNEKKQRHSDRKRNCAQNGSLLAFDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE56</accession>
    <name>A0A914HE56_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM184A/B N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE56"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1668.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1668.t1"/>
        <property type="gene ID" value="Gr19_v10_g1668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039478">
        <property type="entry name" value="FAM184A/B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15665">
        <property type="entry name" value="FAM184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein FAM184A/B N-terminal" evidence="4">
        <location>
            <begin position="213"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="845"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="957"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="269"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="902"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="930"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="957"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1668.t1"/>
        </source>
    </evidence>
    <sequence length="1058" mass="121437" checksum="97708BAA8B2E34E0" modified="2023-02-22" version="1">MGGQSISRPLSHSCLGHLTHFASIEAENREQRPIGCDVMENSSSRSAIVTPPMNRLSDRPGSSLQPMPSNSSSPPSISFSRTAIAPVEPFPHQNSPHSERPSAHSPCPAICSWPAPPPNPRAELKPTAIAAPLTTPPTSSARSTLLNAIPPQQSFSNTHLQLQNPISSQSPCSKSSQPSPIALLDSVPLLTMFRAASLNSAPPGGNSPISHWGRETELRQKIQSLEEIVADYERQKLNVLGTFTDFSEKVSERESEEVLGAKKDFDERMKSFQMLQEQFEREKEQALEKLRQDHQREIQALEQRFSHSQLMNLEKKYIKEIQKLEEERNELRTERERLGEEFKGKLRRAESLFEMELTAARMLYMRELQALREHEEALKDEMTARQEESHDRLMEQQYQSRQSKDELVHCREEMAQLERALGQKADEIHRLSKELAIARRQTEEAIRRLGQIEAKAEEFVRELSAQKERAEQLRGAEEAREQLEETVRELRKELTMLRSRADMLEVERDELRAQGESQAQLHDSQVTALEAMLKSVTSEKEGNEQRCQEMLDRERAEAEERELILRREFSAKLGELEEQYNGLRVHVERDNIEPFGPENVKLWEEIECLRSEKGELERELSAERTAQQYDTDGLTKLARAIQSLKRSTICEKSSDEEEVVEEVEGWERVPPVEALLEKLEQLKRSVEGIVREKRKMETRLELLGEAEFNWLKRLTEMERELEEQRERTTKAEEDHRQTKQSKELQIVTLKPKLEERKDKAAPFVPDETRNRTEELETKLREAKKRAETIEAEMEKAIGKLEEEHAMEMEAKIDKLNREHERTVELMMQREREMEEELEELRIWKRNARDERTEIAEGETQTDPGGGEGKAEELKIWKRDARDERTEIAEGETQTDPGGGEGEAERAPFREKDELIRKLKEDLEEAKCGKNPSTSKEGGRSQSIAFVGEHFLMCQKAIDEGGKEEKKEGGRRPDFLKGFEQRKVQSPTQLSRMDATMPRDVLPTQRSSQSTTSTPTSQRSLLSPGGAQQQRASPARQIVPMGKNGRSNGSGEKRPAWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE62</accession>
    <name>A0A914HE62_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HE62"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15792.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15792.t1"/>
        <property type="gene ID" value="Gr19_v10_g15792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08747">
        <property type="entry name" value="RGS_GRK2_GRK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05606">
        <property type="entry name" value="STKc_beta_ARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000118">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000068">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF18">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="12">
        <location>
            <begin position="54"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="191"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15792.t1"/>
        </source>
    </evidence>
    <sequence length="478" mass="55003" checksum="ADF9458FC381384C" modified="2023-02-22" version="1">MADLEAVLADVSYLMAMEKSRSQPAARASKKIVLPDPSVRSIMQKYLEKTGEIRFEKIFTQRLGFLLLKDFAENVAETSCPQIKFYEAIKEYEKLETPEERLTKAREIYDHHIMVEMLAHSHNYTKASLQHVQRNLMKNIVAPDLFQPYVTEICDQLKEDVFPKFLESEKFTRYCQWKNLELNMQLAMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKLKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHGVFTEAEVMFYASEVILGLEHMHSRTVVYRDLKPANILLDENGHVRVSDLGLACDFSKKKPHASVGTHGYMAPEVLAKGVAYDSSADWFSFGCMLYKLLKGHSPFRQHNKNKKHSQDKNEIDKITLTQDIEFPDQGFSTECRDLLEGLLKREVHERVGCRGKGAEEIKTHPFFRGVDWQVVEHVILFLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE73</accession>
    <name>A0A914HE73_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">eIF-4F 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HE73"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1632.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1632.t1"/>
        <property type="gene ID" value="Gr19_v10_g1632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF69">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1632.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="27327" checksum="D91C8422873D80D7" modified="2023-02-22" version="1">MLKRTRPRTQAQKAETTVPHDLIERHLLQNQWALWYLKGDRNKNWTDCLKKVSVFDTVEDFWALYNHIQPASGLSWNSDYYLFKEGIKPMWEDKGNLKGGRWLVQVDRQKRQAKLDIYWQEMMMCVIGEQFENLGDHICGAVVNIRQKGDKVSLWTRDANDDSANLQIGHILKAKLNIPDTEVLRYEVHEEYSIRTGSAVKSKLNIPARDKEQQQQEVEKRKQHERSFSQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFL4</accession>
    <name>A0A914HFL4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16910.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16910.t2"/>
        <property type="gene ID" value="Gr19_v10_g16910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16910.t2"/>
        </source>
    </evidence>
    <sequence length="445" mass="49215" checksum="DE499E81924D74B8" modified="2023-02-22" version="1">MAPAVPEWTRQWHKFLVERIGIDSLQLGLLLLMLLSLLTLLLSIMSVSLRFCCCPKRSAGRCRRRKPTEAMPSRTPTNGFTGTNEERRCLLQPNGICAVAVSSRAPHQAQQQQLEKKAEPNFEVDHRAQQQAVTEPTVGAAPPQPPAQFEKSAIVADPVKASLCQIPLALTPRGNLPPSRPAHFSVESPPPPRRFASSGGRTQVLPLTSQNRRRVPPLVMLMAEQQQQQLHHRQQMMARGRMPTTPDSRATTTTTTTGGMKSCATIPEDPEETNHRPLADELLSIDRTFVSADDEQQQEEEEVHRFVHRLPLHQPPPTFEVQPPTYSPPEPPSKMMPKNFWCESNNLSRSSYGAQTSLNTTTGSSADESITTSSIVVVVVNRRNVVEEEEVRISELESETGAPPAPPPPSTMSSNGIGHAAIVQHHRVPRSISQQLELMNMTTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG22</accession>
    <name>A0A914HG22_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HG22"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17040.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17040.t1"/>
        <property type="gene ID" value="Gr19_v10_g17040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="10">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="112"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="177"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17040.t1"/>
        </source>
    </evidence>
    <sequence length="550" mass="63170" checksum="3B793ADD5556F177" modified="2023-02-22" version="1">MSKVHAIIKRIQSQGCGQWHFVEDDDDDELSDFELKARPVSLVDTLNKSTEELETEARIKAALKHIMQSVDLDEVTSQDIRRRLNEQIIVDLRRHKEFIDHQMLVILGQLDKPSKIFEYLYLGTEWNASNWEELKENGVQFILNVTKEVDNFFPDQFKYLKICVSDESTTELFMHWQRTYEFIREAKEKGAKVLVHCKKGISRSASTVVAYAMKEYTWGLDAALEHVKRKRDCITPNPGFMEQLQTFQGMLQASNNRHKFVDGAVWTEQDDAKRIAKIKADEKRLFEEQMGIKLAPSTGGGTSGEGIIADEEIDRPPTSPKLHHAQSFKQHYQQMSADQSIFNSTINRRPADLWCFHCASPWNAISEPMQRVIKNLLEIRRAEYPAAQMMRRDCVEPKDLDGLPRQICRGYSHCQTLILTDHGSGSAFTMRGCAERFGAVDVHVLARRGDNMCKRLHEKVDIQECICERRKYCHAGAERASTLQFTPMSGWQQNVPSAALDKTNLVPAPEALQRNSGRRRRPKNWETTAMVVVLLLHFTHYAAAIQIKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGV6</accession>
    <name>A0A914HGV6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatidylinositol-glycan biosynthesis class W protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGV6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16841.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16841.t1"/>
        <property type="gene ID" value="Gr19_v10_g16841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044501627" evidence="6">
        <location>
            <begin position="26"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16841.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38103" checksum="352AB1338D193C4D" modified="2023-02-22" version="1">MTLLLIATSLAILAVDFTLFPRRMAKTQYYGQSLMDTGTAAFIFVNALADHDVAARGQSPRQRAAKATMQIFALRMPTLLALFLIGVGRSVFIQLSGYGQDVTEYGVHWNFFLTLFCVRLFVICVPNSMLVFVGVLLGVVYQIALRFTWLEQWLLRPDFTEPRHGFLDQNREGIFSLCGYCFIYAVSLMYARGSNKLMPRDKKLSALNVACGLGFSLCCYGLQRVLEDYFGLIASRRLANMSYSFAMLALFSTICALLQFGQLVVPLPQDARWGGLVAAVSRNALLHFLCANLLTGLVNILAMASSNFEIHGHPIAETVTMLAYALATSLLIYAIHLAKKRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH13</accession>
    <name>A0A914HH13_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17097.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17097.t2"/>
        <property type="gene ID" value="Gr19_v10_g17097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502657" evidence="1">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17097.t2"/>
        </source>
    </evidence>
    <sequence length="137" mass="15165" checksum="D08611A187AA41B2" modified="2023-02-22" version="1">MPISQFPSFRFVLFLFLLKIAQNTAFFADSHIGRDSHIGRDSHIGRDSHIGRDSHIGRDSHIGSPPSVALQGERVRRQAPGKGDKLEGAVCNMHSECVTGLACKMSGKLVGRSEHDHKTIDGILINLFTRILFSFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHX4</accession>
    <name>A0A914HHX4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="11">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:22650"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914HHX4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17092.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17092.t1"/>
        <property type="gene ID" value="Gr19_v10_g17092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17092.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24536" checksum="C51793F150083CB5" modified="2023-02-22" version="1">MSDGCPRAGGASGGGCPLSSDDKIDPFNAMPPPNQKPAPDQPFHLSTQRQKSTIPKANVTVDGQLETWEYPSAQMFWNAMLKKGWRWKDDHLNQRDMDSIIRIHNANNELAWREVLKWEQSLHRECDAPRLKSFHGDAKNLSPRARFRSWLGYQLPFDRHNWLVDRCGQEVAYIIDYYDVGKVDPDTQLFAHLDVRPAIRGPGTLDKRRSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ39</accession>
    <name>A0A914HJ39_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HJ39"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17103.t4">
        <property type="protein sequence ID" value="Gr19_v10_g17103.t4"/>
        <property type="gene ID" value="Gr19_v10_g17103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="term" value="P:base-excision repair, AP site formation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nucleotide-excision repair"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HFD_TAF11"/>
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        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
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    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
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        <property type="entry name" value="DNA_glycosylase"/>
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        <property type="entry name" value="HhH-GPD_domain"/>
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        <property type="entry name" value="OGG_N"/>
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        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
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        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
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        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-glycosylase"/>
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    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="105"/>
            <end position="280"/>
        </location>
    </feature>
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            <begin position="317"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
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        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
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            <dbReference type="ARBA" id="ARBA00012720"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
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        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17103.t4"/>
        </source>
    </evidence>
    <sequence length="552" mass="62357" checksum="2C813706B023E94A" modified="2023-02-22" version="1">MLSSATVKVSGGPKTPTALDGLEFFVTDYGIFGVQMSTKFASKRQFVGRIFSGQKRLDVDLERLYGFWSSQDIHFAKLLTENREMLQGIRILRQDPVETLFAFICSANNNIPRISQMVEKLCQFYGDSVDSNSHRFYDFPTVAKMATHLPDMEHTLRTAGFGYRATSIVKTVEMLASGVLTINNSAEDWLRSIGDLSYREAKLSLMRLPGVGPKVADCICLMALNKHQVVPVDRHVFNITAQIYMPKFMKDRKTFSRAIYEKIGEFYVGLHGDYAGWAHSVLFSTRLRRFALNMANKKIETVDFDEAFGLLEDARDQQQALDEEPFPTASAATVPTSGPSSVDHPLQQPIHPVAEQLEERVPDESDEPEEKRRKGTAEEDESEEAIPPLPPKLDEESELARLKLQLLLSNFTQEQLDRYEAMRRASLPKSIIRRLIHQFTGVTANQNVVIAIAGMAKVFAGELIEEALDIQKAEREASKHNGKRNPIDQAEQSAKSPPQSADGPLTPRHLYLALDRLDRQGRESRHRMIFGFPLGLYRHWTRARFEPGAMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKE3</accession>
    <name>A0A914HKE3_GLORO</name>
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        <submittedName>
            <fullName evidence="3">Fucosyltransferase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKE3"/>
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        <property type="gene ID" value="Gr19_v10_g2290"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
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        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="1">
        <location>
            <begin position="83"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2290.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17572" checksum="BA5A45F4A2AE06B1" modified="2023-02-22" version="1">MASLPVQKTLTSDNQTVGEEFWKALRFGAFMIDFDGIAPLQIAALEIRQSIGKNCMKKLCNTTDSKAPIVILWNNECLGDALILLLDRGFPTYLPLTAKNKCPFKCKYTANRNLEANSSMLIFHLHGRCLIDRWPKKRRHNQNYVMFTVESPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL74</accession>
    <name>A0A914HL74_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL74"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2162.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2162.t1"/>
        <property type="gene ID" value="Gr19_v10_g2162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2162.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7707" checksum="019329C170103484" modified="2023-02-22" version="1">MKSIKSETPKAIRKLLKQNLKRKSCYINCKKIQCADGFQCQVRISISKLGDLPYDQSIGTFPQCVSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLP2</accession>
    <name>A0A914HLP2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g25.t1">
        <property type="protein sequence ID" value="Gr19_v10_g25.t1"/>
        <property type="gene ID" value="Gr19_v10_g25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF21">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037907818" evidence="4">
        <location>
            <begin position="24"/>
            <end position="2415"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="525"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="639"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="1234"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="1278"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="1348"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="1392"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="2086"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="2130"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="2202"/>
            <end position="2236"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="2246"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1500"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2326"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1510"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1549"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1578"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="525"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1348"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2086"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2130"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2202"/>
            <end position="2236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g25.t1"/>
        </source>
    </evidence>
    <sequence length="2415" mass="268877" checksum="F35684E46CBECA5F" modified="2023-02-22" version="1">MRKIEQLFLSFSIFAKIFAIAFGQENCAEAPNAALQKVCEQLYRWDKKAREAPPVEESIVLPPAIPGLETPLFAAELAPIATTPYQCMDLGCLCSYMGGSGQQGSNACRLPNGRPLNKALRREYRMLSDEERARFHSALLAIKQSGEYDRMAALHAQFATSGSAHSGPGFLPWHREFTKRVEIALRQVDPTVAIPYWDSTLESALPTPSDSHLFTAEFMGTTDSSGNLITGDFAGWRTLDGRPNVMRSVGTDGTAFREQDLQWFLDQNSIEMILGFTAPRQGCQDRSSWNLMEYTHGNVHVFIGGDMTDQSTSANDPIFFIHHSFVDLIWETWRQTKQTRSDRETIYPLDMQLCSAPQHFGSGLMRPFQPWRNTDGLNNKYTDNLYEYAPRPSCRDGSNCGSKYLFCDRSHGNSRCAAKVRQGGNCLGFSNGEDVCLNGQCQGGRCVQTNRPSPSPSPPPPVAVQTQTVPARPRPTTQISCFNEHECCEVWSRKGECQRNPTYMNAWCKASCRQCRVDYDMFIECNDRHVNCAQWAKRGECTRNRFWMAENCRQSCDKCQVTRAQVCSGGSESRTNQHRITAPTPRKSRCSSTGCFNENICCQFWGLMGECRKNSAWMTCNCRVSCGACIPQGYDFGSCSDYHPECRQWAIRGECRRNAWMLENCKRSCESCVSFRELRQICRGRRAGGPVKRRRARTFGKFYYDDGSVHAEQFEDAGALRFDTKTSTSSPTSSMLLRHVRNVQTKVTPNGTAEKIGPPSHMRTIIERIWATGHKFPKMWLHSLCLLLFALFPIQNAQKSCATAPTSALRTLCEQLHRWDTNARAAPPVEDKIPLPPAIAGLPAPTLAAELAPIATTPYQCMDLPCLSSYLGGKQANKAIRKEYRMLSDMERSRFHAAMKTIKKNGEYDKIARIHADPTIGGGAHGGPAFLPWHREYIKRLEISLRQVDPSVALPYWDSTLEDHLPTPKDSHLFTTDFMGETDAAGNLVKGDFAGWQTTTGKANVLRKLGTDGHGFRETEINWFLQQTTPEMIFGYSAPQQGCTVTTNYNLIEYTHGNIHLFIGGDMAEQSTAANDPIFFLLHSFVDFIWEMKRQRQGQFERESLYPMDNAQCASALHFGSALMRPFQPWQNRDGMSNKYTDNLYEYAPRPSCQSGPNCGSKYLFCDRSHGTPRCAAQVKPGGNCTGFNNGEDVCLNGECRANKCVQTEKAKPTPKPPPSGSTGSPLKPVHVACYNEHECCATWANKGECQRNPSYMNAWCKASCKQCQPDYSMATECADRHKNCGRWNGQGECNKNLFWMTENCRKSCSKCGVARSQVCGGGAGSKTNQNRVTKPPPKQAKCTSPMCFNENLCCQLWGLMGECRKNSAWMTCNCRVSCGACIPQNYAFGACADYHPQCGQWAGRGECQKNGWMLENCKRSCDTCVSFWELRQSCRGRQSGGRRRRSTAAPAIEFNDDFEPIGLLRMVREAAINESSTAIPLKGISVVGGDSGGKIKNLFGGDVGPAKPPAKEASLKVHGQDELEKSGNKSSSAAIDKSELSPPASTENSEKSEKAKESDNKNDDGKKPNLEEKASNRNDSTTTTGDGSEKTLGKTPPPDLAGDLASSGGTTNSSGPVPPPKNTASGEDPCAKAPTKSLRIVCQQLHRWDKNAREAPPVEEAVPKMPSIPGLDMGLLAAELAPIAASPYQCMDLGCLCKYMNGNGQEGSNNCQLSDNKPLKKAIRKEYRMLSDQERAKFHAAMNAIKKSGEYDKIAALHAAFGQSGAAHAGPAFLPWHRELMKRLEISLRQMDPSVSVPYWDSSLEAQLPTPGDSHMFTKDFMGDTDSQGNLVVGDFAGWKTLTGTPNVIRHVGQGGKGFTENEIQWFLNQRQLDKVFGYSSPQPGLCPMELDYQLIEVTHGNVHLFVGGEEAQPAGHMSDTSTSANDPLFFLHHAFVDCIWEQWRQSKQNRNDREIAYPMDNAQCASAMHFGSAPMRPFQPWRNVDGLSNKYTDNMFEYGPRPNCQMGPNCGSKYLFCDRSHGPPHCAAKVRTRGNCQGFSNDEEVCYNGICQRGRCVDTNMEPPTTRPPPPTTFQPPKQSQVACYNEHECCSLWADKGECERNSGYMSSWCKASCRQCQVDYDMNQECTNRHPNCGQWSNEGQCQRNQFWMTENCRQACGKCQVTRWQVCNGGAKSQQNQNRITQAPPAQQAPQCSSKGCYNENICCQLWGLAGECRRNPPWMNCFCKVSCGKCIPQDYVFGSCTDYHPRCWQWADAGECRRNAWMLENCKQSCSTCVSQSELRQMCRRGGRGKREIGMMPSIEYSMQALSRFSRDIDENEEASAPAVAESLPSPHGPPEKATEGAKEFVSGQKKMPDNRCEGTVCSNCKSCTFKRTRVTIIAFLHRIRPLFKAGIAFKLIINNITLMHFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM17</accession>
    <name>A0A914HM17_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the nanos family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914HM17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g274.t1">
        <property type="protein sequence ID" value="Gr19_v10_g274.t1"/>
        <property type="gene ID" value="Gr19_v10_g274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF241">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Nanos-type" evidence="15">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="185"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g274.t1"/>
        </source>
    </evidence>
    <sequence length="1065" mass="122708" checksum="36840E116D76D94A" modified="2023-02-22" version="1">MPSSSSIQRMSRLKLWMTPVRDGHLDVGDFKVWSSDDSSDPIRFSRGSSRNSSADGSTSCSNESPEEMMSMKIGIWKPLPQKTCGFCYIQYKRHCQKLGISFPRATDPGFWVGHTTKDDRGDVICPELRKLKCPLCYASGKKAHTLKFSCSLMACVSEQLELVSEMIKTCAVDVRDVWPTNAENYTKTESITRGAFGIVRFAEASDPAFSIDGLENRSCVIKTIYLQRRFEAILKEIPSTIARKSVQENDLDHQHTTKISRFYRRMVMELYVLCRCRHANIMHLHALFISNGDLHMVLPRLYVLENLSMMYKRRKQSEPIPVTIIAKILRQLCLALDYLQKIGISHRAVQPDNVFLTRGGTVKLGHFAQSRALFEESLDDELCCCKSPVGREEFMSFEKQHNLYFGTTLTDCVGYSFSADIWSLGVLVLAMVSYYPEEQSQKLHKNFAMAMHQEQMPFIWLTVDMLQLRSRLVKSGGEELKLFLSDCLLTLTPKRRVTAAELPKTAEMKKWCLPTVEEDSKFLRKHLIDEVDFANHLKLESDSPNYDVLETKDIPAEFYWDDTWKKLDDMELIVQIFMPPNYASERHRFKFSDSEPLFRILYTEIVSARIEFTDLLTLDFGVKQSVFDFVQKNCADSAVEKKMGNRAGGVLRRQIKLPSSRSVEVEIRTSSPPHRPEHVPLIECPLAVLSSQSPPADNQWPQTKTAQMFKWHFSFLFLVFSVILLCWVLYDRSVDGYVFEFKNTTLESDALIEVPPPTKPVILLWTPVFRHNSLKLHSDCPFSEQCFLTYDRRALGHADAVVYHIPDIKWTMPSALSSSKLADRSVQPDFPEQNAFKANAVNVFFSQENPSTLTYYYQSKKLEKAADKFFHWTMTYLRSSDFPMPYGGFWVPPEETRRLGFSDKRVRGAVWFVSNCHTESKRELAVEALSKHFLINVGGKCAKTEEGQQLCPRTEPSCDHVFAAHYFFIAAENDICREYVTEKYWSRYQLPSVPIVMRKYIYEGIVPNNSYIAMDQFESPKAMADHLNFLMNNPDEYLKYFEWRAQNWSIAPWNHQGFRIGKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMU1</accession>
    <name>A0A914HMU1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HMU1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g295.t1">
        <property type="protein sequence ID" value="Gr19_v10_g295.t1"/>
        <property type="gene ID" value="Gr19_v10_g295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000001">
        <property type="entry name" value="Myelin transcription factor 1-like, a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF15">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="765"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="859"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="815"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g295.t1"/>
        </source>
    </evidence>
    <sequence length="885" mass="95673" checksum="6AAAC200C36E3DE4" modified="2023-02-22" version="1">MAAEELAKWARKLAVRIIHTNFGEFVSAHRRAEAESVLMRGKIRLQRLLRLSLLSMKHSDFMASARRPGGYSTRKSLPTFYLLPKFPPRKCSFSLICVQFEVERQGNSVPFSLHIGSSTPRGLRRPTRTPSLNKFTLPMDPAGTTLCHSSPSPCSSAVSPLFSRHFHQHQLPSTSSSSDQDGTEETAEPFVGNGFNAIREEEEEAENDADGNRERKSGGSRKRRRKPEAKDIVRMVTSPLSQGSALMEDNLEETAPLPSAGHRHLLGRPDSEPSAPSLPFPSADAIEAFFRRGSAIGTDSLPPQRQAVPSSAASLNFGLFTLNGGSSTGGSDGGTGEEEKKTEGMEAEEDTDKKREEGDIVGSSPLFGAHPSALKVSGSLSPSGVSSAASSLHGSVSPAASGKTSQGPSFQFPGRRSEGGKLSCPTPGCDGSGHQTGLYTHHRSLSGCPRRPDKQTIQMLALQPEQQLRCTYPGCEGRGHVNSSRSSHRSLSGCPIAYADKMARRGLQQQQSRGTTATPLAKSAMDRAEEQPQPPNGKRADERRKSISSSSTSSTRTDGGEREEKPNVYAAGEGHQPVNLSCQRTKTEEAPPEGDLEQRLTSNVPSASIDELRNALLASFQRQLLGQSLLCAPPQYQSTESEEPALKRTRTEEDREEEASEGEKGAKDEQQQLLLHQLQRNRAVPVPTAEQQQQFQPMSASHLTHMTEVLQAKGFQMPAGGLGALPSDQLLHIATALAAQRAAAIQTAQLQAAAIWQQMMATAAASGDNGTNGTHQQMPTSVQLQQQQQHNHKQQQHQQHLITKLLQPKEESSSDDTSSTKSASSAAVVPTTTSSSSAPPAALNCHPMALFAQLQAQLLHHHHHQQRREDEGEGRTVIRRVGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN30</accession>
    <name>A0A914HN30_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HN30"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2121.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2121.t1"/>
        <property type="gene ID" value="Gr19_v10_g2121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036917712" evidence="2">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2121.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9699" checksum="501225DD77DD60E1" modified="2023-02-22" version="1">MIFKFSIKIVIFFSLILSSLAIKSLNKQDGLINNKEKTSITSTLTTLRIGIIVFFILLAVCSIACLLLLVRCMFSAKVRRVNLENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNN8</accession>
    <name>A0A914HNN8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNN8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3200.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3200.t1"/>
        <property type="gene ID" value="Gr19_v10_g3200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3200.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26976" checksum="F224FD76C5771F34" modified="2023-02-22" version="1">MSITKSTGRTPKLDKLNPIQLISLDKLNPIQLIRMLLFSQSLINQKGKYSAKERNQIEDKIAKHLKVSRKKINKWKKEFGLCRKVFYEQEERKHLVEKFDQMKAELRRAGFKNSYPNQIDETVSKELGLSFMTIYRWKRKLGQSTPQHKHSDSEQKELMKLYYAIKGQNPKTSDEKITKKLNINRATLVRWKRQFKQQQLHPNSVDGHSVDENAVANVQEIGNSNPRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPC4</accession>
    <name>A0A914HPC4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPC4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3175.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3175.t1"/>
        <property type="gene ID" value="Gr19_v10_g3175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3175.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30085" checksum="4464059B973A6FF7" modified="2023-02-22" version="1">MEKAESVKVKLEELPLKTFDEIFGDGWWDKGEAEDLKMPAPTNFGQNVHHQIDRQNTQIGQIEPNSIDQNPPLSDHSGQIKPNSTDQNPPLSDHSGQIEPNSTDQNPPLTESDHSDNAKKRKIIAKFHAMKDEFMQKGKYSAKEWVQIEEKIDKTVAKELGLHFKTIYKWKKELGQSKPNKYAHNKQNELMKRYYEIKDQTPKIRDVDIAKILNIGSATLCKWKKQFKRPQLHPNSVDGHSVEEMPRQIFKKFENSNSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPH0</accession>
    <name>A0A914HPH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HPH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g250.t1">
        <property type="protein sequence ID" value="Gr19_v10_g250.t1"/>
        <property type="gene ID" value="Gr19_v10_g250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="645"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g250.t1"/>
        </source>
    </evidence>
    <sequence length="737" mass="82395" checksum="DDC65A1D0FCEDA64" modified="2023-02-22" version="1">MAPKRNKQSKAKDRSPKSTDLDTANKNIEGQDNAKTPATARRSRRLQGAEVEFTENVLEEIEREKRSSRSRSRSATPSTDRPSKSKTFDGLKKTSAGPSNSQPNCLATHCPSDGLAADCINRRRSSPQRLRVDFDDSEANESFGISDKSLGGKAKKFSPRNVVEKRRSKDGKSPKMLSVEADDDDHQNGGGDKKQNGGDKMQKDVVVGVDGVEAVEEGEDQLFSEDEQIGQEEEESEAEHEEGNAFQTKTKQMHNIGAEEEEERGELNWTTDDMETNDEMAVGCSAERREEGEVGDDDDGHDEGEEVEEDDGHDEGEEVEEDDGHDEGEEVEEDDGHDEGEEVEEDDGHDEGEEVEEDDGHDEGEEVEEDDGHDEEDDGHDEGEEVEEDDGHDEGEEVEEDDGHDEGEEGGPCSYEEDVEDAGTVQERRKKLPKSSLDDKFFNLAEMNAFLEAEDKKEEEKDRKRKSRNLGQIENADEMDQLISSYEEANLRPRDWALSGEAIAEGRAKDALLEQFVEVDYRATAPPTINEEKTAQLEAIISKRIKDGKVRKSLAEVYGDKFATKINEGEQLGGDAKPKLDPTVEGIKHDLDKLFLKLDALSHFQFRPQPIREDVKIVNNMPSLHMEEVGPQAAVGPEVNLLAPEEVKRRVKSAPKATDERTETDRKRQRRQKKKKQRILASIGAMNGGEVGGEASERVTKRKKDGEGTEKKKKRKLLGRDGKEKKRKRTKSKLADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPR5</accession>
    <name>A0A914HPR5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPR5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2763.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2763.t1"/>
        <property type="gene ID" value="Gr19_v10_g2763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2763.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19944" checksum="14891B17D18E76CA" modified="2023-02-22" version="1">MAVLTPAAFATQNAADFITNSTAQIIRTEMGEVWTGPSLLLSNPTPFVDKFETFILINCMAEQPIGVDEFCQFVDGRIRWQLFVDIDQSNGETAHLWPDFYSQNCENFAQIISTSFRTNYCKIWLVGLKCPATVGALAQFDLTSNEIDAKFQKLKIELKSIIVSREELADFEGKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ30</accession>
    <name>A0A914HQ30_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2845.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2845.t1"/>
        <property type="gene ID" value="Gr19_v10_g2845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222:SF76">
        <property type="entry name" value="MYCOBACTIN IMPORT ATP-BINDING_PERMEASE PROTEIN IRTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="771"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="814"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="918"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="997"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="84"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="410"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="775"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="1094"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="699"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2845.t1"/>
        </source>
    </evidence>
    <sequence length="1342" mass="149033" checksum="BB89B0A3FC331720" modified="2023-02-22" version="1">MDQQRENPPNVSIAFDDSVNNNDDRRPLLLEETEKAGYGSMTMPAGDSFRSVKHWWKKKSKLKTKQRQLGIFAYSSSADYALIVVGTTASVLHGAGFPLLSIVLGGMTSVFLRAENSDFAHGETPRQNATFSNGVPPISKEQFQSEVAAYSIYYLLLGLVMLITSYIQIACWEAVAERVVHRLRQTYLKALLRQEIAWFDTVQSGNLTARLSDDLERVREGLGDKASMFIQMFAAFIAGFVVGFFYNWQMALVMALFTPAIALTGAWMGRITATRTQVEQDKYAVAGAIAEETFSSMRTIHSLNAERQEMERYEKALEDGRRTGLLKYLYMSFGFGVTHIITHASYAFAFWFASRLIVWDESFDRGTVFIVFFSVMSGSTALGAALPSFASISSAKGAARHVLSVINRQPRIDAYSNDGQLLRKARNRSVSFKVSPGRKLALVGPSGCGKSTVVNLLLRFYDPTNGEITLDEVNLQRLNIRSLRDEIGVVSQEPILFDGTLEENILLGSEDATREQVIQSCRLANAFEFINKLSEGIQTRVGERGAQLSGGQKQRIAIARALIKNPSILLLDEATSALDTESEALVQKALDTAQEGRTTIVVAHRLATIRNVDQILVFNNGQIVESGTHEELVEKRGIFYEMVTQQQILQRSSDQTLQKIDESPDAEESVDEEAEVFAVGSDEKAMASPLLAESLREGSVVSAQSSPRKGSSLRRKHSPGMVRRRKTSTASLRTSASTDVLQISQMQKELDQSEVRPSPISKIFRFNTGNWHYAIFGFVGCSISGLAVPFFALVYAQIFAVFSEPLDKLQSDAIIWSGMFLLVGFLNAFGFFISANTLGRSGEALTKKLRMEAFSNLMRQDIGFFDDERHNTGKLCTRFATDTPNVRYVFTRLTVVISSVVTLLGAIAIGFINGWQLALILLAIIPLILASGYFEMQQQFGKKMRDTELLEDAGKVASEAVENIRTVQSLNKQMAFHNKYAELLFEPHRANMVQVHIYGVVFAFSQSLIFFMYALAFWVGSLFVLNGSMSPASVFRVFFAIAFCGQSVGQISSFIPDVVKARLAASLLFHLIEYPSLIDSLSTRGLDKKLEGNIQFRNVSFAYPSRPDVLVLNRIDFDVKAGQTVALVGYSGCGKSTVMALLERFYSPLRGSILIDGVPIEEMNIHRLRTQICMVSQEPILFDCTIRENITYGIADRERVTHEQIVRAAEQANVHNFVLGLPEGAQFHIRRGTQLSGGQKQRIAIARALIREPTVLLLDEATSALDTENEMAVKKALENARRGRTCLVIAHRLSTIQNSDLILVVNDGRVVEQGVHDELLGRGGIYKAFCETQILKEKKESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ42</accession>
    <name>A0A914HQ42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQ42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3611.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3611.t1"/>
        <property type="gene ID" value="Gr19_v10_g3611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF282">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN ASIC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3611.t1"/>
        </source>
    </evidence>
    <sequence length="759" mass="85837" checksum="2F47DFF6CE925694" modified="2023-02-22" version="1">MKDSSFCQCHRRKISRRSLSSQESRRVQKTAIGSKNEFRAGLEITFSDFAENTSAHGIPRAYTSRGRLRRFLWLLLFMCCFVAFIGQAVQIVKRFWRNDIIFVFEFWEIIYKFSFIYFLVTVCNLNPYKNSLAREMTAVGDTLSAYDRAMDLASSASHSHHRSRRRRANKNVGTFPSTTRQRFYTKYEGLLAVFSFCDCSASKLGCRALNDENAQDGQNVTRPLCLCFYNQQNEQVWPCFEPAQWSERRCGGCTALGNCDFVQDPPTMNGTTDDDNHTNDGIGGNAAKSSTTAALWPCLCAPAIRICVRVDDNLPQNESVGTVNNTTSSSTVGEPPLLERVPKIWELKKAELPRMETPEQKESREEAYGLRGVYDPIAIRAKAVENLVFAVSQLSEAEQSQMGYSKREFITKCSFNGRECSVDEDFSLYVDPTYGNCFTFNAKPDKNVLSERAGPNYGLRFQVFVNVSDYLPTTEAAGVRITVHNPEEQPFPDTHGHRNFVKISFGIRLKCVNRLPSPYGDCVQHGKTEEYIYRDKEYSTEGCQRSCIQRMLVSKCGCGDPRFPRYLNFRNCPVGDPGLRACLQREMHSAARSATQQPDCICRQPCREQVFSITYSCARWPSSDWALYGECDSSLSGAQCLQFHREQSAIVEVYFEQLNYESLQESEAYGLPNLLSDFGGQLGLWMGVSVITIMEVGILISELFILFFVRKLINWLSGLLNIVVGTDRGVGPLLPSGDMDPMAKKRRVLVHNGSVIRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQT3</accession>
    <name>A0A914HQT3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQT3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3044.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3044.t1"/>
        <property type="gene ID" value="Gr19_v10_g3044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3044.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21897" checksum="56F095F7A1EF00AF" modified="2023-02-22" version="1">MSFNVVNTSMPKSMFSPINSGNRWNPTACHVNLALSEPDRLVVQRNGEANLGWSSVRAEKPMSKNPYFEVKIVEKKSFVLIGLANKQMPLDKFVGHYEGTFGYSNYGYFWGHEVDGCSHLSNGRPVIDGKPKFGVGDVVGCGVNLKNGQIIYTKNGQRLDTANLFVVSAADLFPCVSLGLLLGTKIEANFGPKFQFNIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQX4</accession>
    <name>A0A914HQX4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gamma-glutamylcyclotransferase AIG2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g3635.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3635.t1"/>
        <property type="gene ID" value="Gr19_v10_g3635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026314">
        <property type="entry name" value="YLP_motif_con_p1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413">
        <property type="entry name" value="YLP MOTIF CONTAINING PROTEIN NUCLEAR PROTEIN ZAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413:SF0">
        <property type="entry name" value="YLP MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="3">
        <location>
            <begin position="1277"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="674"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3635.t1"/>
        </source>
    </evidence>
    <sequence length="1438" mass="163442" checksum="975E7F642995E74D" modified="2023-02-22" version="1">MERNNTLGGAFPNLFGSGGNSLGPSSAPVPSTVGQQEANAGSYNYFKDDFGDINPFAYQQTAATAPQMSPSMASPQKAPRKKKTAKQHSNMTESMANMTIQQQVGQQQQQPHHQQQAVEQQQQQQQYLQQQQSLQRTQLQGDGSTSFQTYQQLSNPQGSASFQTHQQLSNPEGSTSFQSHQQPQAVQHPMAGNLGYQQVGSNSSNYMMAPQQQHQVVGQQSGERLQQMLSMQKHALASGGGGNQPPQMQAGTLGLPVGNSSSTYNMAQPQQQQQNQGVAQHPQLQQQQQQAISSPTGNMSFDMNTFFAATQQQQPMANVGNQIQYSQPAPSLLPTDSFVSPQYAPPQQQPLSPAGSFNMHPAYQQQYQPQPAQAQQTKQKAPSPLGTKSGRKPINLSDHRQEVYATSQPTSGRQSTMERTKTGGRRPLQHDKSLSLGPFPWQQQQQQQQMQSPSRSGRRPLSIGNNSMGGSSSYDGGSSPNYGHPLALPAPPPRHGGSSGQSFRRNESYAPEQYNYGFAPALEYHRMPSNASVAASGRQMVPARQASGKSGAIVPARKKSNAIVQPGDSPISHGITDYKPSRYTEFEKKANKGAVATETDYIETVYNQNKPIIKRDNMAFLSNGRSLVPKETTTTGSMYHVYPLTRLQVGRLMNLFGKYRMDLPNIEHFVLEKARHMELELQRQRIELDSLKIEYKTNQRIQINLEEMEKQYESYWMRETDDPWEKQLKIWHESWSGVQIFLTETDKEKKKTIMSDVTKIYKGYKGNYFLDLFVATALSRTALLRMTMYNSTRGTRGTDCSDLIELMITMSLEEREQVGLPTIPVPDDQEDEESRSSRQYKGAERFTKNKKDQTKTFCSELDNESELKYNADKAIGFGLSHLGVKSTKWNAFGYWINHMCRHPRTIQFDKETRHMADWVDELDQFLKDLNFTKDIMELFTEYSYSRLRLIFDAYQSSTKKSVYHEIKEHWDKRRTKKSRNSEDHYVQLVNSIVEDVYMGRPYFFARLLSEKFPKLLDNSTANDQDAFSDITRILLHRGPVDLVEVNQEYLRMNNKVIRNSKDAEGGILATLKTLAKHAATKSGSKDRGGDEAQTLKGFVKIMEWSMLGETQHQIRKFTADEYHVDLDQFELAENDTEDDGQEEYEDDQYYLEDEQQQQHQYYLENNPDYYYAEYDDDQQPYNNQSGQQQMMPPHMAAHGHVPFHQGQAVQHHIGGQAPGLYYGDPTQQQQYQAGTAPPQYHHRQQQQQQQHYGDQRQQRQAGGPAEIVVFIYRAMFLFVYGTLRKGFDGEMAHKLASESEWIGKAMLEKAQLYRVYCDEFAFDYPALVLLDNNAHEECDKFVVVGDLVRLTNAEQSIIWLDEYEECGAQFKQPNEYVKKEVKVKLLRDEDSNEHVQNCVATTYVFGWPIKDSNGNLVPPVRELIVGGDWLLMHENRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTY5</accession>
    <name>A0A914HTY5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTY5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4646.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4646.t1"/>
        <property type="gene ID" value="Gr19_v10_g4646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="215"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4646.t1"/>
        </source>
    </evidence>
    <sequence length="428" mass="47564" checksum="CB01CFAA28AB340A" modified="2023-02-22" version="1">MPKPNSLVGRIKHLLDTGNGADVHFLVGGGDEKELLPAHKTILMAASDVFEAMFPFDARNAKAAAETKPVEVPDAEVGAFKAMLSFIYADDLSGLNEDNAIAVLYAAKKYDLPELVNSCLKFPIWKLNNIFFAFAQTRFLGEEHIDVNAGALILSEEFLQIDQQLLCEILDRDELCISEEIAIWNAALRWADEKCRQNGTEPSAENRRAMLGPALSKIRFPLISQEDFSDNIVPSGVLTDAELVSILLHYSRPDRARPEPYQLQFPTNGRAETKFGSRSVLAERPIPKKGIFYYEMTILKQVGRETVFIGLAPKQMRWDKCVGCFKGTAYQSNGYFWGHEIEGCSHWNGRPVIGRKPEFAEGDVIGCGVNLATRQIIYTKNGHRLETAGLFVDSAADLFPCVTLADFGEKMETNFGPNFKFNIAADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU91</accession>
    <name>A0A914HU91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4719.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4719.t1"/>
        <property type="gene ID" value="Gr19_v10_g4719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4719.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17889" checksum="50957ECDC1641650" modified="2023-02-22" version="1">MECEHWLQQQSVQDRICIRCSRIQGFAVKDVALLSALFFHRLWRDTSSNRLSIKMPNKPSYDGSSDEQKNFETISKEQQQLIYPKFRYIRNLYPLMFFLDLLCMLIVVFGYSLFGEGGTGDVVSDIQGSNNTCLQTKLSRVFRKSLLKAARTTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUI6</accession>
    <name>A0A914HUI6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Adenosine kinase</fullName>
            <shortName evidence="10">AK</shortName>
            <ecNumber evidence="3 10">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="3 10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HUI6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4122.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4122.t1"/>
        <property type="gene ID" value="Gr19_v10_g4122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="11">
        <location>
            <begin position="111"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4122.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34046" checksum="97686A1A7C008881" modified="2023-02-22" version="1">MAILVGLGSPLLDITANVGTEFLEKYGLEENGAVLIDEENKGTFMPIFNEVLALDSVTLLPGGSALNTIRVFQWVLNGINGTNKNERATFFGSVGMGPIVRFVRASPAADKFTLDFLYLPENAELIEASKCFYSAAFFLAVCPEAVLHLAMTAAKLERPFLFNLSAEYIAGRYKKELNEILPFVDVLFANDGEAIAYAPTNGFKSTCDLHKIALDLTRIEKAREGLGRIVLITRGDRPLIVAQNGITKEFPVILVEKMVDTNGAGDAFCGGFLAAFACGFPMEKCIKYALSSAATIVQQKGCTFPEAWELSASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUY3</accession>
    <name>A0A914HUY3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitinyl hydrolase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HUY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4226.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4226.t1"/>
        <property type="gene ID" value="Gr19_v10_g4226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106018">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="524"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="560"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="715"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="823"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4226.t1"/>
        </source>
    </evidence>
    <sequence length="1214" mass="138570" checksum="7F8C327135243DC7" modified="2023-02-22" version="1">MCWVLTSYLKLMKGPTHFDREKDSQSLYDTLLRCSRLTNISECLAFANKKANCAPQTWHRLNWSEEMRRQGVEDIDSWTVSDFNANFVHCDTYPEQLWIPKGATTQILIASCRFRSRARLPVLTYFHKNNGAALCRSSQPLAGFSARCLEDENLMEFIMAANPSSTHLYLVDTRPRVNAMVNKVQGKGFEDTRNYTNIQSHFFDIENIHVMRASLNKLLEACQRTQTMSQYLKTVDSSGWLRHLKTLLDCSVFIAQTLKGFQVLIDKDWLGFGFKFDDRCGHLGASNEEMAREVSPIFTQFLDSVYQLLRKKPMCFELNERFLVELNEYAYSCVHGQFVGNCDKDRKDLRVSTRTNSLWAYMDLHIEDYQNPFYEPNSDSLLSDIDLNLSSIASREYLNDIVMNTKLHVQSMKTASDLENSRAACAWQSLLSADECANEKCRREFLSRIERRVHCDSCGQIYCHRNITMPDKDKTELYTDLTDETHFDFCRMAWLERKFLGLCDPLTMCIPESAFVTVVLPTTKSMDVASAVFRLFSKNNNSSIGLREYVYGLSRLCRGPEPERIKFVMQLWDSDMDGLLSRKDLTDCFKFFGLSMVEILSHSPLPTVPDALRIYEFVCLANANPTVRDALLSFSNKIWMALTNETKPMKTNKGQDNNAGKEHDHDKTDADDEQSSSSSSSSSSSSDEEEEGENGHNLKKTSGKKENTENRSQLGGVQNIGNTCYMGAAIQTLANVSELTGFLFKHEQHFFHLPLVRRYVQMLRTLLVQKETASPLDLKEVISAKSALFAENVQHDSQEFMQFFLDALNESLKNIQIGEELENKKATDEEGRADDGNVQEDGMWQNANNHWKKEALTSKERSIVLDLFAGQFLSKLHCPNCAHSSNTFELFTMLQLQIPIPESIWVFFKVVKSDSDSAVVRHALQIPPITELVRLKQLICERICIATDEVEILIQNKRDGKYNADFSRLFNAKNAHRGGADCTLMGIPLCDINIWCIETNNLSADCSDCLMYAINEKTRTLDDPSLLNADRQTDARLLNVDDCVKDFTGVEQIDGSHCDNCKSSASKLSKQLSFTRLPDILVVSFKRFIFVPSLKRFVKQSAPLSFPLDNFDLRPYFAPDVPEQFLNNFSRYFCIGIVTHSGQLNYGHYCSYVRNVTSKRWFFCNDDKIELIKSGCVPTPKDAYILFYQRATDTPSAPAVRREDATRKDNNVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV27</accession>
    <name>A0A914HV27_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HV27"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4747.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4747.t1"/>
        <property type="gene ID" value="Gr19_v10_g4747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4747.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27545" checksum="35B2721A96390AF6" modified="2023-02-22" version="1">MRSKEKQQPILAPINAIAQPEVPTSSSTIEDYAAPLEAKDEPPAPYQFDPNEEFYLAPPTCQFLHYRDAAVLVGIVEVLLLICALYTAMTYYIGNHLVGVWAPLLIASVLCIAIGTTVAMVYGIRHEQPQLLWPQIYFLKVEITMLMAGAVFSIACMCLGIESTNWIFSHFVSVPLMELNFGPIWPFNLAIASFSGAALGIWFDVIVRGCLDYLLDKEYFAQGPQPIQIGECFGTDGSREERRMEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVL9</accession>
    <name>A0A914HVL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4901.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4901.t1"/>
        <property type="gene ID" value="Gr19_v10_g4901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4901.t1"/>
        </source>
    </evidence>
    <sequence length="410" mass="44630" checksum="91382A9979D0D6EA" modified="2023-02-22" version="1">MTTDSGGLFNSLNISNLLSNMNSSSNGGFGPSATPLSPSSSANNGTLNNSNDNNNGTSPMDSAASLMQQRWTKAQMDAAVAAATILLAITGNNGGLKQQEESLAMETDAKSDPPTTSVSSSTPTPAVDVNMEDRETHSPRGNHWIHLGTFDSETEMQIVRNKEKVSKRRTEQLKNGVKVRYRCNTWKRTKCGFQMFSFQHAETGLIELYECGSHDHSGRRKLEYDLLGPLARRKATPLPIINGHKMNSDKNAASSCGKRASSPQKPPKQLRMMAEQRALTEMAVAASAAASEFAEFSDKPWNFSLTESAKLDDLRTMARQHGLRLERNSDIQLSIYRLSVNGGRGAFLLVIVDSADAVTLTAAAGAGTIFSPSGGGQQRWEKADWIQFFSSSSPEFTLLKKSKKVFCPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVM3</accession>
    <name>A0A914HVM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4196.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4196.t2"/>
        <property type="gene ID" value="Gr19_v10_g4196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059039">
        <property type="entry name" value="ZNF380_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23406">
        <property type="entry name" value="ZNF380_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MH2" evidence="6">
        <location>
            <begin position="154"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4196.t2"/>
        </source>
    </evidence>
    <sequence length="1081" mass="122154" checksum="BAC826DFC791ACC7" modified="2023-02-22" version="1">MSAAQMSAALVCGANVCGAQMSAARKCLRRKCPRRKRLRRKCLRRKRLRRNVCGANVRGANVCGANVCGANVCGANVCGANVCGANVCGARLRRKRLRRKRLRRNVCGANVCGAQMSAAQMSAAQTSAAQMSAAQTSAAQCLRRKCPRRKCLRRKRLRRKRLRRKCLRRKRLRRNVCGANVRGANASRILPAKAEFVLGSSLTSTEMQPLRTHADTSAWASGWPALLTVFCLQTNPRPLCLCSQEMQTSNTVFSQQRVPPGATMLIFDYLLFAGMLEKAREDGYQHVYEIVKMCFVRLSFIKGWGADYPRLDVTSTPCWLEIQLHQPMAWIDAALAQMDPPDHNGVTSAKVKKQDFSRKPPKSRENLLNQLSDFHNLCSMQFKSKTQTAHINGRKHREAQLKQRDQQLKRSEDTTNERSNNRTAEVGLKRKQPPGLDASDSEGEKKLKRETDVVLIERTTVPWKAEVRTSDREKSERNSGANVIDGIPKGFFDDENMNNRVRETIEKQKQISNEIDRFYKEVEEMETQKEDEHEELAERSAIRSDIEMIDEQIERWKAVNELEKQKELKCLTMTLKSILIRSESCFEECRAIFAHRWCYYASLSIRARDPDARVLIITDEQESPYKRGPLSKELWWFADETGVESLSHTNPTSTSGRRRFAFYEADGFYLSPEELDHWEHGGVGLMRGAKVVRVNTDENFVELEDGRRIEFGKCLIATGSDALMQNSLGRISELEDHVTVLGKAADFRKIYTKMDKMAADGDVQNVVVVLGGGLLGTELAYSLNRRYARDREKASLKIVQLCYEPGVLSEILPEALSDYSTDLLRVQGIDVLTDTCINSATFSPKNLKAHQRKLCLNTKTSTINEKLDREPTRQQILCDHLIIALGAEPRVELADEKTGIKLDKENGGVMADEHLHRRRRCTHWQHAQITGRLAGENMTDGHKTYTHQGAFVTMFGPFGHICGVGDVNPHSLNTTTIMAKNERNVAEDSDDELRAVVLYTDPNTNIVSGVLLFNILGLGEEWARKLIGDTLPLNGRISAEYAKLFELWESESGDKKTMETKEENSGALTNEELEAYQRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW62</accession>
    <name>A0A914HW62_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP synthase subunit s-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP synthase subunit s family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HW62"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4326.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4326.t1"/>
        <property type="gene ID" value="Gr19_v10_g4326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000168">
        <property type="entry name" value="Distal membrane arm assembly complex 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="527"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00076566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4326.t1"/>
        </source>
    </evidence>
    <sequence length="761" mass="87430" checksum="8F4796540EAEA7AE" modified="2023-02-22" version="1">MNPIQKKTIPPELLAEIVGALRFEICWATTRVSAAFDHFLLKRQLAWIRLEIVRQAILRQKRNRLATAARALKRVAANLPPTKMTRVMDTVTCHFRLVNTAGMPEAQGLAPHISFALQLDAVLLAAVNRDDIQLMHDTAAFLHSLYLTPENVKQVMPKKDPEDQTRFDRGAFTMDYLTMHTQFKYLDHSFDNIRRCREYSRFQTMQYDQRFLPDRLIFLGADLAAAHFIVHRNGSVKFVGDDRWFKREGRLGTYHLPGKKTEGFYVEAIDASDTELMFEGFDNLYDLEFLRMLSLRNCRWIDDWVLSRIGGMFANSLEMLDLSNCHRISAKGLLGLRSLTKLRFLRLDGLDKVQGLAKSALLLEETLPNLMVFGVDYDRAMAEHETEQKLLSHDRVIIDAKDNVFVEDDNGRLFYVKGCVNERVSVCDADKPLMTSLIRRELPKMDAEEFEQVNDLSKGKLRHFLLGSPSGYSWNEQVETMLTFEESWQHWEAVPTDVKMMPRYKRTVLLEERRRALLLEAAEEQKRLGREGAEQDEEAGEEAGECDGEERGEAEQHDDDGKGEEEKIVVPKKISPVAIYLRQNARWDIIGNVRLEIVRQAILRQKRNRLATAARALKQAVKNIRPSKMTLLMNSVTCHFGVDNDAGMPQAQVLAPHVSFALQLDAVLLDNVNRDDISFLHKTANCKQKSCTVSPRWLNDRSKSDLDGRVLNRTKKPEKRLANVTEKEEEELNSTTTMGRGRRRKLLLQKKLLNIECLHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX73</accession>
    <name>A0A914HX73_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX73"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5308.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5308.t1"/>
        <property type="gene ID" value="Gr19_v10_g5308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5308.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16255" checksum="9BDA8F29683512C0" modified="2023-02-22" version="1">MCQYGEQINLIKNLGISEKTFRCWKKEFLLPVNSQQHSDIEKLKLLGKYHKIKQRNPKIRERDIANILNIPRTTLYGWKKQFDSVDEHSLPKNRSTYAPDNDTSEHPMASLDDNLWAWNLSKKKRTERIEVEHHGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYI9</accession>
    <name>A0A914HYI9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYI9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5663.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5663.t1"/>
        <property type="gene ID" value="Gr19_v10_g5663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5663.t1"/>
        </source>
    </evidence>
    <sequence length="582" mass="65859" checksum="8E473DE82FCD743A" modified="2023-02-22" version="1">MKGRVTARQQRACMTEQVVGRDGGRRKKSDERHWGASARGPAERARARPPAGSRADFFSPHLLAAVVECNFSKCPMGETSVFHYWAKRPFFRYWAKCPMGEMSMGEMSMGEMSNGRNVYGRNVQWAKCLWAKCPMGEMSVGEMSNGRNVYGRNVYGRNVQWAKWMSCLKPKPGTESQKDLSASFEKMKKSAVVDGTNASNEDGSVAVGTLFSMVEEMQTAAKTFVDSANAFNEDSASNLLQKYAVGILCRTRIENFFEKVGKTNFNDQFKKQTGETRENLCKQLENIDESVLNVEKIKNKFVENLHIDPQMHQNLIKVTENGAFSDENKNKMSKLIGHFIQGLNTIGPKLKESKQYMTPFMKLPHQKGSGKIRRKRDLELCGQPRGCMQRWSKPQKCIGGIVFGSISAALLVMTITLVAQHPELVNRHPLPPANFIAMFCIVVLMIACILVFVISSKMEIPSTSQRLSKSENDDETVEDDVFEDPQESFTKLDKGVIFSSHGEFKKQNVEFAVSRLVVKEACIFNPENPASTERQIERCAHDYVTVRWRNAPDLADAARFMPEWFHVDGMQRRKRIAIEYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ19</accession>
    <name>A0A914HZ19_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ19"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5986.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5986.t1"/>
        <property type="gene ID" value="Gr19_v10_g5986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037115254" evidence="1">
        <location>
            <begin position="25"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="69"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="320"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5986.t1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51632" checksum="C52917AC39883986" modified="2023-02-22" version="1">MKLRTILILLIIGQCLLSPSFVEALLRCKNRRGFNENVKSLNERHYCREYDQYCFSAVCRTTRAKIRPADVQFSVGEGDKKETLSAHKLILLAASDVFEKMFLFDAKNAKAVTAGGKAPLEEIKPIEVPDVEVGAFKAMLSFIYADDLSGISEDNVFDVLFAADKYNVPGLIKACVNFPKGKLRNIFHSIELARKLGKALPPCQDIARNCLDYIDKNAANLIQTEEFLQIDQKLLRFWAVISSKKNFQFGMPHFVGRTKNAVKMGKSDFSANIVRSGVLTSDQMMSVFQYYSHPDADQPEPYSLQFPTKRRTSSDPYKAKGKIVLKIDKVSEFVHVDSRRLSEAVYIRGLPWKILVTSAAYYDRFSFYLRCNDANTDSNWSCAGSATIRIVSQKEGKEDHTQELSRSIFNLSAKGWGMQYFMPFEKLMDPQNGWYDAKNDTVILSAEVTAEVPVGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I195</accession>
    <name>A0A914I195_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914I195"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6561.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6561.t2"/>
        <property type="gene ID" value="Gr19_v10_g6561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase central" evidence="10">
        <location>
            <begin position="488"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6561.t2"/>
        </source>
    </evidence>
    <sequence length="760" mass="88352" checksum="26A3A53ACFBF10B4" modified="2023-02-22" version="1">MMLLWENGPADTSLYYALRICVEQALAEHSKRIAERRLRDLDDLEAEIIAKFVICIGNKMGKAPRKDTILCELQFNEMAKLLDKWDDFRQMLEENKTLWHELMDNERVKKFEVLLKERDKYFPVAESFVGSALSDTDEETFEDTNDKFEMYGNSEINDELLELYSESENWIKQKIGIVKLADLLDDLLLKNIFKNFWNNLHLIHLKIQKYSNDERLAKCQNEATDESLTKCRNQQKYSNDESCESRTENLCACAEYDDKYVKMLENMLKMKTLDSLFNVHHAHDLEGIQYNLIRTLPKNRVNELQISNEISTFISSPEFGRRNKTPILALKKGIESIVEDWAKQLTSIKPRLVTIGSHLMSADMEGSDLDLLCVVHNKINVRHFYGESGVDLFTLLKKKLKGIKNISWIDGKVKMVRIEHVNIEVDLSLVPVPEEYLSGTELLLDDDKLTRQMTYESGIYSLAGYKSAKFQLSLLISAQKEECISLRKAVKVWAKNRLIYSGIFGYFNGAALSVMATKICVLFPDAPLSYLLLQFFSIYSNWDWAHRVPVILDKLTPITMNQIVRFWPPIFSLAAMSVITPKFPEQNAAFNVNDFTFRTIIAELKIANEILSENIKKWQHIFEEIKFKDNFGHFALILCSAINFEEYSKNCAFQKSKIREKLLAWAKQESVAQRLEQFHLIPQSEEKIACRMKKTTAFGRLWLVGLTMKSEYHNENLTLNLLPIYDSDQLPALDVFWIRSFYAEAKNLKKRIEMLRHIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1B3</accession>
    <name>A0A914I1B3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1B3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6577.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6577.t1"/>
        <property type="gene ID" value="Gr19_v10_g6577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037318135" evidence="1">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6577.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45114" checksum="236E08678423FF4F" modified="2023-02-22" version="1">MPGMSTIVLLILSIFKVGEMAHLGGKNSLPTVNQPAQIQQNSFLQQTALNSHPPVVSNNNPFGGDAIIGHNNHFVPIEKEFVACQSLANAAGYQCEFSLDEMMLESNKTNVEIWANFGEENDGTLRLLGQQDASKCNADEDGQAQCDTKLVINSDQIDQLKSISMDEVNDAILQSNKDAEVHRRQLGEGAVTFWLYNKCGKDLMVGGNVQGTVVNNVTCMAKIPAAITSARFWFNKDCNNDEVKHYCDVQAAQPPTSLFEMTFKNGQSLEEKVQFYDVSLVDGFNVPISVFVKDCPGVNISKNYNFNSLLNALPAEMKDLTYNSGQDLVGVKSVCGAFDTDAVCCRNAYNLPGTCKPDTDHGWEQKQIDAYNVMRAAFPDAYNYAYDDQSATKVCKGATDFHIGICTQMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1C3</accession>
    <name>A0A914I1C3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914I1C3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6585.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6585.t1"/>
        <property type="gene ID" value="Gr19_v10_g6585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6585.t1"/>
        </source>
    </evidence>
    <sequence length="646" mass="74371" checksum="13B369913E43B3BA" modified="2023-02-22" version="1">MRRHCSRKHYLIIQTPPFFEPNYEQKDDALPDESQLHKAFVDGVESLEYMYSSQVGKAKVFELVERPANVEELRKCYGTEPKRKANRRQWTQNGQIYVYSAYLDERTNSIFPGKPSVQVLSSSFGILPLHWAWDGTVVRARVRWIWQRAWDPRTEFYNPFLFTCPMPSTNLGNNVESLVLISRNSFCVKSGEGVGIANFTKITKPAKSSIITEQSVFGIRPDRIKIAVCTKGLDFLEESAAFSARKIVEWVLLQRALGANAVTLYFYWIPPNVRNALQRMADRKQLEIVELNLPANSPNQPFIRHQFIQRNRQQKRRHELIPYNDCFNRYSATHHFVLIADIDEVVVPLRHQRWQQLLHELLARGKWRAEPSSISVRNVFKFWHNKNSSGQNANNNTENIASLFSLCWRSDTAQESGRYGKSFVNTRSIASVFNHFGLHRLHANVSNTLHVSEEDALKLHWRQQCPEEELGIEKCQQLNTNLIRDHLLDRFRDEVEEEVIEDGTSEEEDLAKALALSETVEIKTGRIGVTDKDELRQICESWKVKALAANAYLSGTHEGASTSAIPAIRGNQIKEKEKPLFRVEQGELQLSSAMVAIKAAYRILFGWRKVEGFDTKFEFENESSFSNAPMILPKAKLNQLKYEAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1C6</accession>
    <name>A0A914I1C6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1C6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5699.t3">
        <property type="protein sequence ID" value="Gr19_v10_g5699.t3"/>
        <property type="gene ID" value="Gr19_v10_g5699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5699.t3"/>
        </source>
    </evidence>
    <sequence length="296" mass="33421" checksum="6CB292A39B8DFADD" modified="2023-02-22" version="1">MNNNSTPNSSNADFFLVGRCSDRSFLLNSTGTDSNSYAFTSVPNFSAIRGTFRNKTIFFNGHFTYEINDFFHEAIDNVHTLYIIRELKKFMDVLGGNAEDLSTFFGCALRIVVETPIELGELGREEETKNVTNCADNETTAKADDEKKNDGKDDSESDGNESESDESIMNDAPFFKFIRAIVNNFLELSTSRSRHGRLPDDESCVKRSKFCAKFRAKIFNDWSEVLRILRIPVTEDDGHADDADAKFVLHDVFVLRCARGEMDTLPSDLNALFASDQFDCRVICVEKPPEKVAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1T0</accession>
    <name>A0A914I1T0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1T0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6518.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6518.t1"/>
        <property type="gene ID" value="Gr19_v10_g6518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6518.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30542" checksum="4A1C22176DDD0317" modified="2023-02-22" version="1">MDNKSVATNKASVATNKASVANNKASVANNNESVAINKSPTTTGCGSGSNEIGAINKYGPNNNKSGRTCCGDVSIETGTKVVAIVSCVFYMGLALFALYYNSIVYVIAYTLIACVCLLIIFGLKECNPWLFLPYLILGAIHLIDRLFFCFSLLKCATQKERARKLPAWYGVEANYSESAHNSCLSLLIGLVMGIAFFVWTYSIIFRGFLAVKELVAQHWSLHATRLQAQCLARSPPGLPRHTGTARVQRRVWQMPGRLLGSIDVTNGVMKQSMPTLTTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1X2</accession>
    <name>A0A914I1X2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide chain release factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1X2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6739.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6739.t2"/>
        <property type="gene ID" value="Gr19_v10_g6739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide chain release factor" evidence="4">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6739.t2"/>
        </source>
    </evidence>
    <sequence length="323" mass="36747" checksum="2179878537E9C2A4" modified="2023-02-22" version="1">MIPRMSSLVDFQLSYNQKLVDAELCRAESCRTEPSAPKRVAFARESKRRKADTRVLRAEVIFPKSLRFPLSDHPKRGTFEMPSNFEALFGFQIDNSRCLRPFSRRRPGGTEAALFAAELYNMYAKFAARNGWHWTTHEMSKCTKTGGTGINSAIVLLEGDGCYAKMRFESGVHRVQRVPVTEAKGAHAHQHVMYTPDELKEEHMRSSGPGGANVNAIVDVRTSVKVMDERYLAQNVKIAHQRLAAMLLKQQVDEATRRYASNRTLRVGTMERAEKIRTYNYKDNRMTDHRLKLTRHGVEQFLAGGEQLEKGGRLADGNHVKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2C7</accession>
    <name>A0A914I2C7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2C7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6861.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6861.t1"/>
        <property type="gene ID" value="Gr19_v10_g6861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036677592" evidence="2">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6861.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28784" checksum="EDCDAF9825C895FF" modified="2023-02-22" version="1">MRVLLYLLALAFSCFFKYGYCVYDDFKSNEEAMDLVKKYHDGQNTEITSVKDLYDKLKEKNVFGKSITTLTRYVTKIQKEKEAIEAKKYLAGAHQNLLKRQHEVALQSMPGLHATAYLPNQSQSTAWTGASNQSSQFQGQQPNSSRFYNPTQQQQTSNFGTNQSQSTRRTNTINFSHPSSQFQGQQPNSSRFYNPTQQQQTSNFGTNQSQSTRRTNAINFEGPSRSNNADKELDLTLSLGGNSKKNKGKSKYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3L5</accession>
    <name>A0A914I3L5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3L5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g719.t1">
        <property type="protein sequence ID" value="Gr19_v10_g719.t1"/>
        <property type="gene ID" value="Gr19_v10_g719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g719.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="16356" checksum="48371968DF702CD2" modified="2023-02-22" version="1">MDQLLSGLLGGGGGGGGGGENNGQRGGGGGNQQQGGGGMAGLAGDLLGGLLGGGGSGANAQGGGGGDIMSTLFNAVKGGDIGSLLGALAGGADVNAKDSSSGNTLLQMAIMTGITELVKLLLNRGANVNATNEEGKDAVRVAQEQAEQAPDEESKSKYEQMVQLLQEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I467</accession>
    <name>A0A914I467_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I467"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6724.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6724.t1"/>
        <property type="gene ID" value="Gr19_v10_g6724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6724.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36868" checksum="CD88FE098A150701" modified="2023-02-22" version="1">MADSGVEDTARIVIFGCRTDFHRLVQCSTWVVDGTFKSAPELWYQIWVIHGMFRGRVMPFVYALLPNKQQCTYERALERILSGIDDVRPGWRPTTLVIDFEKAEMNAFERLIPGIATHGCYFHFNQSIWRQIQNLGLSGFYLENAEFRSSLKCFAALAFLPVQDVQNAFNAIANGLIEDFQDGDEGEMTGAITNFLDYFEKNWVGRQRINPRFPVRMWNCHDITLEGLPRTSNSAESWHHAFASIFNSHHPNPYKLVEGLLREQVRVDFTCTRLEAGEQVEQFSRIEYKQANERLLALIGENRNGGDFLRACTFYIHYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4U9</accession>
    <name>A0A914I4U9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CFA20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4U9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7535.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7535.t1"/>
        <property type="gene ID" value="Gr19_v10_g7535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7535.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23984" checksum="1E9901C0EC46AE81" modified="2023-02-22" version="1">MFHNTFQSGLLSVLYSIGSKPLQIWDKSVRNGHIKRITDEDIQSSVIELLGNNVSTTYVTCPLDPKKTLGIKLPYFVMTVKNMKKYFTFEVQVLDDKGMKRRFRASNFQSTTRVKPFICTMPLRLDEGWNQVQFNLADFVKRAYGSTYVETLRIQIHANCRLRRVYFADRLYTEEELPAEFKLYLPVRCGHQGGRSAADQSEGTSFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6D3</accession>
    <name>A0A914I6D3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6D3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7039.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7039.t2"/>
        <property type="gene ID" value="Gr19_v10_g7039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7039.t2"/>
        </source>
    </evidence>
    <sequence length="118" mass="13319" checksum="071D49491D71E686" modified="2023-02-22" version="1">MKKKVIGPTGNMASFIELIPAMLRALFNGAREQWRRRRAGERAVQTRSPLPARAQACPPARNGRAPAPPMVADQALPLEEMPPEDAALMDVLKMNITRKQNEQFNNTKKIYYSFQIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6N5</accession>
    <name>A0A914I6N5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6N5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7399.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7399.t1"/>
        <property type="gene ID" value="Gr19_v10_g7399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="401"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="360"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7399.t1"/>
        </source>
    </evidence>
    <sequence length="515" mass="59771" checksum="F8BB6C59ABEEFBF1" modified="2023-02-22" version="1">MVNFNYEWLNPPLGVLGLPLPILQISYLSFITFALIQLASSQRKEIDKHLEQGKYWLSKGQFQEALQHYHQAVALDPSDYQIYYRRATVFLASGKVNAALPDLEKVVELKPDFIAGRIQRGNILFKKGNLKEAEADFEFAVKHEPGNAESRERMQKISQIQAWIDNGLQHFENKDFAMAEQMLNYAIEHCQWNADLHRKRSRCRLARGDTQNAIADIRAVAKLVPDSTETFLELSRIYYEIGDVENAMGQIRECLHLSPEHKECFPFYKRIKKLTKMRQDLMKSVLGEQWMDCLEKAKSILRFEREVDPIQMDVYKYTCKCNVKLSHVAEAIQECTEVLKYGDENDLDVLLDRGEAFLLNEQYEKAVEDFQKAVNAHEGSRRAKEQLTRAQKMLKLSKKKDYYKILGVRRNADKRQVMKAYRKLAQQWHPDNFQDDAEKERAQEKFFDIANAKDVLTDPEKRRRYDAGEDPLDPQGGHGGGQQFHQWHWSGEQGGFNPFGEGFNPFGDNDGKFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6P9</accession>
    <name>A0A914I6P9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914I6P9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7408.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7408.t2"/>
        <property type="gene ID" value="Gr19_v10_g7408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF1">
        <property type="entry name" value="PEZ, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="762"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="1014"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="945"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="726"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7408.t2"/>
        </source>
    </evidence>
    <sequence length="1106" mass="121822" checksum="0EDC78164F5C7C62" modified="2023-02-22" version="1">MPLKLKLGRTSGRYELSEDIYILTILVGDQTIAQCTLTSHSTSADVFRFLAEKHCIKQPELFGLQYQMKATDTEKRMMRWVEPDKSIRRQLERWACRRGQKWAVNLAILHACANVFTLHDTVSRSVYYTLLKLDVLQDSKFATLELEKCINLAAYQLQIEFPNLNSPTLQHLKMLALLPQNMCRNPKFNNDETYAKILSAYEKLHTMQPAYAALLYIVEIQQCDGYGEELFQCKDGSSLEEVSLGYSLDFIFVRRPNGTGHKFRWDEVREIMANKRKVTIKCGDAGALVVFGFEDNEMARYVSTVLGWKWRHARVDAQQQKAARLSVQNLQGGMPSFSLLGSQLRRSTGNVNSVRPSSELNIGTANGGNAAGNGNAFLAPYAMVPSTSQPARTDSSSQSTVHSAQSCCVRPPVNVCCRSVSMGQVSAAVSVANAFLHPAHIPSPDKMSPTAPQLAVATTTAPTTITTTLAPLTAQTQQQQQTRQTSNSSQDSDWLRHEQREVLKKMLTEKRRLNKIGSSPEINTVGLSKGAAVAKCKRQQQQQHNGNAPGTPGPKNGSGRRLGGFALARKIFSSTPNLNSTTGGAGGGCRHQHQNQIVPAGNNGGVPLAASPLVPATSRIIQQHAITVPSTQAPPLPYYSPPPLHIHPTLHPNAFFVQQNGGGIPPPQLPSAPPPPLSALFSQGQLIDENGQQRAVIYPIPPEASPLIRPSNSPPALIGGGDENISRSSPKSNGTSSHSEAPLCVQSSLGSDGSAQQTKNYSVAVRAHNLHRNRGSKIYPYNDSRARLTATKANPDGYINASLLNVPVGKHTQLRYVVSQAPIAKTIEDFWQLVWETNARLIVMLVNPHQITKDDTVPSYIPKQAKEKLTVGEFFLRLKSVSPPMQMQFQSTTSFTLSKRGEARRTIWHLYCADFSEQGVPSSMETFIGLVDAVTSVKRHIENEAKRAAEQQRQQQSLVTKTNSNASKESSRSSSDASKRDRAQSAISENGWTKKLRFESSGNDVGKEQKQQQQSYSASSSSSAESSKTMREEPLTIIQCTDGSSESGLYLLAEVVIRCMESNAPFDIAQLLRDLRYQRMCLVKNASQYKFVYELASFYERKLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I788</accession>
    <name>A0A914I788_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I788"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g74.t1">
        <property type="protein sequence ID" value="Gr19_v10_g74.t1"/>
        <property type="gene ID" value="Gr19_v10_g74"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g74.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9483" checksum="8E374C77318F3D2E" modified="2023-02-22" version="1">MISCCSRVGIASETLCHCHPEHPAAEETGAVVAARCLIIMRNGCLAAADHAALIHCRPRRLPLRRLHLRFALRWVRTAPPLACPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7M4</accession>
    <name>A0A914I7M4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7M4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7382.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7382.t2"/>
        <property type="gene ID" value="Gr19_v10_g7382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF2">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037318137" description="Domain of unknown function DB domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="3">
        <location>
            <begin position="496"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7382.t2"/>
        </source>
    </evidence>
    <sequence length="611" mass="65327" checksum="247F9E1950EDE07C" modified="2023-02-22" version="1">MISAGDRPALHSDQLLLLLLLRLGCQQASSNLLFCCCCARRLRNRKSTSSQPAAGLSQPARANVLSVVHFADQHFDSQWLPQQTASWVPWQQQQQVVQQPWVNNNNHHHHHVDDHHPPPVHHDEDDHHHPHHHHHHFQQHYPPIRNGNNDNQQQQQAVIPYWQEQFSPLGADLAAASSSSPEFQEELPELYKPPIIQHVQTVGQHPQQQQQQNDGSRKTPNGSGGGSVNNAIFTHQQRQQQQSSAATGTVQPTGAGLPAQPTGAGPAAQPTGAGLPAQPTGAGPAAQPTGAGLPAQPTGAGPAAQPTGAVSAAQSTGAVSAAQPTGAVSAAQPTGAGSASAAQRAALNNILRRIIPAVRLPPNTAVAAEKDFVANDGGNDGIREVCDETTCTSGASSSEFDLPPPPPPSRFLPDVEKARIAEHLRHKGLSTPRDGVASDAIPSEEPSKFGTLLSTTVPTISTETAATTTPAPARLLTTTTATTPSQKTPNESFLHCCRAKRVPKICESRCNFEVLNKKTLTALFLNTDKCPSEYGLELFTCAAQDSDHSECCKAKRVQRTAAGNKCLAFCNLSPEAPRVQADASYLPCWAVLNEIKNCFRDKLTAHDSKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8F9</accession>
    <name>A0A914I8F9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Charged multivesicular body protein 4b</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8F9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7605.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7605.t1"/>
        <property type="gene ID" value="Gr19_v10_g7605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7605.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25071" checksum="F4E683B80C1DD532" modified="2023-02-22" version="1">MSLFGKIFGGKKQEVVPTTQEALQKLQEREDMFQKKQDFLEKKIETEVATARTHAAKNKRLALQALKRKKGYEKQLEHIAGVLNTIHHQKSALENASMNSDVLSVVADSTKALKKAHNEMDADKVHDLMEEIAEQQEVANEIATAISNPVGLQNDIDDEELMKELDEMEEEALSGKLLDAGIVPAHSIPSVADKLPNAPTELPKKTAAKKQQEDEDLAELEAWANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9D7</accession>
    <name>A0A914I9D7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Ribonuclease III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23 24">protein Drosha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914I9D7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8110.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8110.t1"/>
        <property type="gene ID" value="Gr19_v10_g8110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007506">
        <property type="term" value="P:gonadal mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19877">
        <property type="entry name" value="DSRM_RNAse_III_meta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000002">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000012">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058938">
        <property type="entry name" value="Helical_CED_Drosha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044442">
        <property type="entry name" value="RNAse_III_DSRM__animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26050">
        <property type="entry name" value="Helical_CED_Drosha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="26" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="18" id="KW-0334">Gonadal differentiation</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="17 25" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="29">
        <location>
            <begin position="681"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="29">
        <location>
            <begin position="826"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="28">
        <location>
            <begin position="982"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="159"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1077"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1207"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="27">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="1094"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="1113"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="1208"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="27">
        <location>
            <begin position="1249"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00078955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8110.t1"/>
        </source>
    </evidence>
    <sequence length="1270" mass="143973" checksum="DB361A0CF2F7ED31" modified="2023-02-22" version="1">MEKCEEISDDEPSTSARAEAQLNTGECSFSASSDSVSHNKKSEELEFTGAIDWADNEVDQCHFPNPLEAVGGSGVTESDNGRNGIGESPFWTQSITPGKFYRRNRTGGQFGTSALHALHNDFETKVLQTIRAAKSEQPKSLPSQVENFLYKCNLNSHHLDSDGSSASDRTTSESSEEHEEQRENCGDRLKGRKRRNGNRKSHQCSSTASNKSGGPEKKSSMAQKEIQRKRDHPAALHPDIGFNESGQLNDGPLCKCSWTAKQSGIRHDKFVGEQQSLTKCQWNSSSIECLHHYVLVVQPTPSAFSRRPTAIQLDGHCYAFDGFSIFLHRPLPEHFSQTPINQWTNDFQLRLVKENMPESFTVRDLELFHAFLFEDLLELYDLNRFSTNNFVDGETQDDLLANCRRTAKSYFQCQLNKSALVEFALQKKGQICVNPAKRPMAIRMDMIDAHSLDGTNRDFYPLLVHFGVKPTAYAFSKRPQYQDALKKHIKIRKTMLTGRNKNVLTSEEKRTLRDSEANLQQLKQECVTRRDTTILINSRGFYSTGLYPDIVQHSLLLVLMCHHIRFHCSLGMLENERLEYVFKNRALLELALIHPSFRANYGTNSDHAKNTINNCGLRMGKGPLKRKGREQQTVGAIHGAIPQLSTKKSVQQQSTRKRGIQALMEIMSIQGSQQVTESPLRHNERLEFLGDAVVEFLTTIHLFFLFSDLDEGGLATFRSALVQNRHLATLADRFELHKFMVYSHGPDLCHEADLRHAMANAFEALMAAIFLDSNLEECDRIFSNALFKDDTLLKKLWTTLPEHPLKRNNPFGDRHLIEKVPCLRILADFEESIGIRFKHIRLLAKAFTRRNVPYNYLTLGNNQRLEFLGDTVLQLLTTEYIYKHFPHHQEGHLSLLRTCLVSNKTQSFVCDELAMTRYLVIPEALLRKGTLAQLRLKDKADLNEAFIGALYVDRGLIYCRQFCRTCFFPRLKYFIMTQRWNDPKSQLQQCCLALREGGNGDPDIPEYKTIGVEGPTNTRVYRVAVYFRNKRLSDGMGSSVHQAQMQAAQNGLESHAHLFPKFTPKYKSIRNSINGSHRAEPFELNGNEPDGEGSTISNSAQKCTRTDVDAKNFESSWNSTPKFINNELQPRHGQKRSRGEENGDEPFLHPNVKRRTVSLVLERSNDSTGKGLKDKSYWTPRLEAIQQALQKSRQQNAGIGTVHHKWDSTQSKSAGSHFFFNNTPTRHRSKVSGAEDNGSQMGEANSPLLLPPPPPPPKLLPPSPSFDTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAM7</accession>
    <name>A0A914IAM7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAM7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8146.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8146.t1"/>
        <property type="gene ID" value="Gr19_v10_g8146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8146.t1"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120475" checksum="964D8866C16CD2FB" modified="2023-02-22" version="1">MNLVPSTAAPFNLSLFNSILSSSARREDESEDDDTEENEQRKWRRIEGHRMGREAKAKCDGSVSDEENDETSPQVTSEQHRDGAVHAQHQQQPQQHMDLPAIAMQLLQQAMFRNEGIHHQQQQHQQQKDNEKFSAVPLSSLSVHSDDRSSQQRPSNAVKPNKSGAQSSSAGGSRRAASKGLISAAATAALMAPSPLGALPAIPGALAVAASPAAQLFREDDWSWHRNPAAAIRSGGTNKQTPVWKYFVYNKTENLSRCIVSTCTYQLKGPHTSTLACHLKKHAAEYAEFQRLKSDYTRERMVNGQPSSSSSAGGEHPSSARSTPSVGYPSGGLLPNGTAVGGDRRSPKSRIFGGRFANCAAFGDEQSVQRNLLPRGLQTSNGGNGIFGRQQQQHFHPLGGHAPPHHFAQPPFQHFLIAAAAMAGHNGMQQQQFTSPPPQSDYTLFPQMGTSAPIKSDHLEMNQTMNGFNQLSQCHSHHQLKSDQDIAEGDGKGGTCGGGTGANLLDILNLLSKRAEAAASKEQERRAEDEGKSEGRKRKSTKRKCAVKKDSDRQSEQRTLREDGQSEQRALREDRQSEQRALREDRQSEQRALREDGRKRERLVDGIEEDEEEGTEESQTLSLLAHSVEHILKEEQEQEEELEKKRTKTEHEEQKMNQLEEMEVEDELSAGANEEEETLGPRLSSMDRLTLFLGTAFSPTVLRHLMEENPFLRQFCSSMGCDNVLTLERVDELLNTQLTLMNNQIRQRLGRTRTSALLVDIRCERCWRFRKNSDELDQTEENCQCPTGNQSNLLCTVTLHHKKAENPPILLAMRRIVEEKVEEEKQSEENGRERDGVEEVGKGLATLVEQVLSMYFSDLPSSRPSLVLVHPPSFRPLPSSICSIPCLPAILPQCLQKRLLAVLSKNSEIRQMSAILAEKISNADKTDRAQLETSAGNLLLLPSTSSDGPAEASDALFVCAKIMLQHRKIAENGSEWESLRELCRLHDIITTNSQWLHFEEVEEALSAIRKERFVSLDGSAQRIAAELSKASDALKVMQHCGLINCVPRASIGPNSIFASIIEIDAHWTERNALILFNGNRRTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAR5</accession>
    <name>A0A914IAR5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g8177.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8177.t1"/>
        <property type="gene ID" value="Gr19_v10_g8177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF55">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TANC1/2-like winged helix" evidence="5">
        <location>
            <begin position="922"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1366"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1221"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1599"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8177.t1"/>
        </source>
    </evidence>
    <sequence length="1673" mass="181710" checksum="EB4AF72B50EBA9CC" modified="2023-02-22" version="1">MAAPSPSALLAAVARDELAPRRPSPSAAGTPFANSDGAVGGGPLSTLRRSLRQMNPFRSRLFRLPATPRLSRSKKVLARGEEFTGWNFERPSNASGDASHSLRPFCASFGSADVPPFAATQMRPQRRRLSQMPSPSMYLQYSQHPMAEPGEQCGCCTAGKELDDLDAFLTTMESIVRRGAPVGGSCRVVRHSNEQLEQEGLLSDSRGLARCTVAGNGGTALLPEAGARRVRPPIPSFDPPPFPPFANDCRECPQFLPSTCYAPDGEMFAARWQRPAKSPRPLSHFPCEQSPRALSRRRPVGLLLDDCGGNGNPSGDSENFVPSAQFAHRQPNSPSQSSAITLLNTASAVNLAARGARSASTVSGQQQKCVRSSSLFPQTQLQRRRSACSALSAGVGIVEETEEDGTTTAVMAEGTANYYGKDVIRLMEAAADGTRKADHLGPQPIGAHHLPPSTSPTAVSVPSLLPVPSPLFPLPGETVADVGEFVGREWLFRDLCHQLMTEQAQLILVHGTTGCGKSALIRHIAVHSPNFGEASAQGSSTDAQQQQHNTVDSGIAIGNGSSSAGSGGCNSSGSQLSLLNLPLHLPETLAPSTTANAATLSPARTQHEWLHALAINVVAVHFAQLHNSLSCSVPEFIRSICAQMCSSVQLKLTYGKMIRSDARLHQMATQERQSLDIEPYELFNELISRPLAKLVKEEECLRERAARGKRSSSKSSDYGSNGGAYAVGAEGRRRPFARIEPLLLVLIDSLDEAAFHRADGGECIGWLLRRVLSCDGACPPQLRFVCTSSSPGGVSQQQSLLSQLFGTLRDGVRSIQLDDWEGDERIARDLRLFVERRVHGSPALEKWVHAQFRRQSFFASPGPQPPNGPNVAEFGAQLVAHVNANFVGLKMALAMLAEGRFLSLDALPSELDGLYSLHFRHKFPTSAHFRSVSSILSLLLASLRPLNVEEMLSILNMAQQSPDLDQRELRERLSQLSPLVACEHSLTPASSVFLPVHPSLREWLLKEATSPDAEFVSDIRHSHIMIALSLVKGRPPPSLSSPQETFFELAHHLLKANPHKYMDSDLAERLGMPLGRDCQVKWLKMFGGDLAKALLCRRNVFYPNSKVSRLLLLAGADPNASEWPDGTEEPLLCSFARAGNLEMVQLLLQFGANPNAGHPPPLIVAVERGHEAVIRVLCAHPGTDLFVRDANGHGVLYHAAAHDSIGTVALFVDALDDAGGKSAGMPERSMDEERRAVPSHKRYSACSSSYEDELHSQRTRQRFGNEQNNQPTTNHRNYVGDRTQTIREAFEVAAERGSARVCRFLLDNTDTVLDTSRGMCIACANGRSEVVQFLLSRGATLSPEQTWNGKSALICAVESGSWDLVDGLSPLMVAARHGHVGLVDLLINRGAKLDMADAHGRTAAMHAIEARHSSTVALLLERGCALFARDTHGNTMLHLLGRHPNKCLIYRLLEDGLSLEDKNKEDLRPIEVAIRAGQLVAADTFLRRGARIRSLTWQIALSAHPPLVLVLLRKLLDDAQILLRRKRTAEAQHRLCYALQKCDELLEKANSGGAEAVRRMGPQLRWVKVQTLFSMATLKRRCNDLCEAIALASGPLRSPSGCSSGDECGGAGGEGPERRAEDEQRFELHLLRAKCHFDARDLERARVDAQLATCMRPGDSEAQNLLAVLSTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB91</accession>
    <name>A0A914IB91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9240.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9240.t1"/>
        <property type="gene ID" value="Gr19_v10_g9240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9240.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9433" checksum="A80981E8561D807E" modified="2023-02-22" version="1">MTLLSSAPLDLNPECQDLMRLDQQEMSSVPKMRLSVYCRHHIHLIHHFRMIWEVFGDSSATEIANQPEASKIQIPSGAFQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICU1</accession>
    <name>A0A914ICU1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab-like protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICU1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8710.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8710.t1"/>
        <property type="gene ID" value="Gr19_v10_g8710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8710.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34328" checksum="A95CEE30A43E7599" modified="2023-02-22" version="1">MRLMSAHFAKVLVYASSNVACFAHFPRTKGNGQKYPKGTFVRHRHGNTMPIGCYDPNDALGGWWERIVGQAPEYTFSLAKMFVERMLEEAELQWHNNETDSVNNDVLLVNAGEEDHHHHTMSEQQINVKILVLGPPRSGKTSIANYLADSQDAVSKDYRPTQGVRIVEFESNQLELEGDRVNAEVELWDCSGDRNFESCWPAIRHRCNGIIFVCNPELSTGNDLLIWYTEFALRAEIGTKNLLVLLHHTNESTNHSAIAAFHLPSEMGAIPVIPSNIDREGEVLRVAFNNFLCDIIADVHSTAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDL8</accession>
    <name>A0A914IDL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8911.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8911.t1"/>
        <property type="gene ID" value="Gr19_v10_g8911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8911.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23527" checksum="A45EB8925A177E6F" modified="2023-02-22" version="1">MTNSCKKIVGKRICRPPKEKEQLTYSPITLRDVEIAFFVYCANSFSLKNLVGIQRVQKRFCCSNFCWKMLRNVSSKLPNGWLKRCRDKSKHSSVLNMHSLIFCLMTVASYPPMLIAIGLAERNMKRNQRMLIAIYSRSDQLRKFRLAYPSIYANRFPSFQGQLIKLQIIITHRWGCFGAETVHRRYVYPFYQPNFKIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IED3</accession>
    <name>A0A914IED3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IED3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9119.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9119.t1"/>
        <property type="gene ID" value="Gr19_v10_g9119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9119.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10437" checksum="FC801B6D361806F9" modified="2023-02-22" version="1">MPCHLQRPPNRFHPPDPAPRALIMLPENQSWRFNLIAAVTPAEQGVHDTATNTNSTSSNITKLCREFKRKCIFGSVVKEDENETETIAVQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF12</accession>
    <name>A0A914IF12_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IF12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9311.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9311.t1"/>
        <property type="gene ID" value="Gr19_v10_g9311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9311.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10708" checksum="3104A9114D685DB8" modified="2023-02-22" version="1">MMNNARDLLVNATKHRQETAWKKHEKRRAERFGMKDSAANARFSCILDVLKHRSSQFIVKETSSSLFLLVRFNFLDLFHFPSLGRSAGFDMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFC9</accession>
    <name>A0A914IFC9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9723.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9723.t1"/>
        <property type="gene ID" value="Gr19_v10_g9723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9723.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16921" checksum="CA5F6EDA61D1BCFF" modified="2023-02-22" version="1">MRWSQSTASSRAALPVLHDSATGVMACWCYKYGWSSVFAERAIPKNNFVMFYYEVTILENGRHGIYIGLATKQMPLDKCVGLYEGNYAYASWGYFWGHAVEGCCHNRNGRPFIDGKPRFGIGDVIGCGVNLATRQIIYTKNGQSLGEKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IG17</accession>
    <name>A0A914IG17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IG17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9573.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9573.t1"/>
        <property type="gene ID" value="Gr19_v10_g9573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037617328" evidence="2">
        <location>
            <begin position="30"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9573.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17214" checksum="5E97945DAE3336BB" modified="2023-02-22" version="1">MKTANPNFLSAKALFVLLRYVVLIQFCTCSPHPHTAKRLRENGHQQMGNGFALNGHIENGFQLMPKQKKIQLQYVQDKDVDKESPDAKTVGTADHHTKQHGPSSVFKWPAPSHSLMERFRQAAVTSDNGICSEIGRDVMMQKQGNAVDAAVATML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGX1</accession>
    <name>A0A914IGX1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGX1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9798.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9798.t1"/>
        <property type="gene ID" value="Gr19_v10_g9798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9798.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24566" checksum="09A16F1D855A95E2" modified="2023-02-22" version="1">MSDNAKKEEQQQQTKEMKRSLGSLQIRRATAGNGAQIVNRSGEWQPIQIPFPNTVIGFAEISISFIDQTVIEFLQRIRRLFDSNGTILCIGTAAINQNHSWEIIWQQIWPLFNSRRFGGRALQKEEMVVGFIYADDPSASTSKGGNGRWVGWKFIWPLVNGNIYNFRLNFSDHDRLQQLSSAILCNCANLELIGAYRPPLNFRPKTTPVLLRWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQY1</accession>
    <name>A0A914GQY1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQY1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10576.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10576.t1"/>
        <property type="gene ID" value="Gr19_v10_g10576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10576.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20043" checksum="0D6E80CF36D5E6D0" modified="2023-02-22" version="1">MNYYQNGKENGSNSGANNNNNFKFYNEESQEKLSANIKSEHSYARSGQLWTLIRQKYMLTFRLCRECSQELFEAKGRNIEECSGPHGDDNNNNNSDYNGDTNDNDDTGGSNVPKGGVIVHLRLCKSCTAQNMEISDLHANPKPLNNDNNYRSNYSRDRGRQGYYYSNNAKRGRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR85</accession>
    <name>A0A914GR85_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GR85"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10657.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10657.t1"/>
        <property type="gene ID" value="Gr19_v10_g10657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038156621" evidence="17">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="27"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="307"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10657.t1"/>
        </source>
    </evidence>
    <sequence length="533" mass="61593" checksum="79C2CEF580F94B98" modified="2023-02-22" version="1">MPLFPSPLLLLLVICWLGFVLSNEQAKRLFDDLLLDYNRHRRPSDHQRMGGDWIGPSTVRLKLRLSQIIDVHELDQIMTVSVWLRQSWMDLRLSWEPKEYGGVSALYVPHEMLWVPDLVLYNNADSHYNITIGTKATISHTGQVLWEPPAVFKSLCQIDVQWFPFDEQLCQLKVRPFIQPIFYISSFSLVHGVTPRIYSVSHFGMTSTAPKRRWKTALARTFLLLLNDLCVIFWASSDLSDYYPSVEWDVMSVKAVHHSRVYPGRSPAGGARDGRKFADIVVFPCVGISFLTILVFYLPSDSGEKTEIMPATSTVLPLIGKYLLFTMCMVTLSVLITVYALNFHFRKPTTHTFSPWIRRLFLRWLPKLLFMRRPLDLSARLLDGRPKVPKRENRTVAQLHRRLDHSLGPICVLRHSPLEAMCRPPLDERLRQLYRCPKVEKAFENVCFVAELLRRKDRDQKVDQDWKYVASVLDRLFLVLFALCCFAGTAWILLQAPIFYDRRRPIDLQFQPPETFPAGVGMDGGDASEVMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRW2</accession>
    <name>A0A914GRW2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GRW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10605.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10605.t1"/>
        <property type="gene ID" value="Gr19_v10_g10605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10605.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="19794" checksum="901A46D0EF7C6113" modified="2023-02-22" version="1">MPLHWTSVDTRYAILCAAVPSLSAFAGSMIALKDEELVRYLKSQSFPEFAGRYKYAFLLVNTAVAAPFGLASNVLYKVGGGFGRVDTKVALALFGATVFSGLCVLPALKNKNIKTVAANVAILAGLSVATTTTFFNIDKISAYLTIPFTVWAILCTAMTVKATITSGKKDDGSQSAGGDSKTTIFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSG3</accession>
    <name>A0A914GSG3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10881.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10881.t2"/>
        <property type="gene ID" value="Gr19_v10_g10881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10881.t2"/>
        </source>
    </evidence>
    <sequence length="438" mass="48830" checksum="F9B5DA737C6DD60C" modified="2023-02-22" version="1">MVLQFSYGLVYTFGNLLPYLASYLRWKVDPQLNDGSLIWFQSFLAGFPFAFLVGAYLEKLIGARWGAALGSVLYTGGLALSYLSIQKSYFSLFITLGIFSAFGHGVAYNCVLTQCQKWLPHRVGLVSGLITAGFGSGAFLISPIQTKFINPNNFNVDANGYFTQEELLERVPKMFLLLAFIFGTLQFFALIFIGDPKPQEMLLKNESEQENARIDPRILEHRLSMASCVSYTSTIHYNAPTHSKSAILCSDTFFFIFVTLMLNDIWVQTISGFYKAYGQTFIHDDFFLATINAFAAVFNTISRISWGAIADKFSYQLSMSIACTFGAVLMWTLGLVKLSGSPTLYFVWICAMFCCVGATFSLVPYAAHRCFGSDNFGFSYGCLQMAMFAAGIFNALGSQFLLSIIGFQIHFTFIGFTMFMSLLLTIFVSRTQFGQLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSY9</accession>
    <name>A0A914GSY9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSY9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10102.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10102.t1"/>
        <property type="gene ID" value="Gr19_v10_g10102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10102.t1"/>
        </source>
    </evidence>
    <sequence length="766" mass="82444" checksum="D295FB5981CAFDE5" modified="2023-02-22" version="1">MPQIERGRKELHRQHQTSSTSTARDGAHKSSRRSPVSRRSPAAKRSASGRQRSVERKAQQKSGSSSLKEKTKSEAATAKVEQSQPKSEVDQKRHVARDAEPSARRQNATTKREVPSSPVGDRRRPRRRRSPSTTADEGTTRKRMRHDDEHGTKVDDKLATKTLKDAKLDEGKRRNVDEDSHRTSRRGAAAGADGVVSSSVKEEDGNRSRPKSSSPSAANVANLTSSSSTANANTKDGTLVAANSAVAKEDEAFGNDGFSRARGRPAASSNLTTMPSLRGPKRSTNVQDASSTKPRILPPNVSSPSKEFAAGVNFGGRQNGQPKQQQQNTFNIIVNELSEVSIKREEHPLRGFGKMASRPNRGQSFVRRGGVGRGGIFGATNQQQRGMGQRDGMNPARTMMTHKHTAASDSFSSNAGFGSTNANFSSGAPYQRQHRHVQQQQPNTHRRHRSLSMDKKEPAPAAPGKAVQSSVVVVGAGGAANASVPLNPLAVPRGRNYFLHDARDDLAAAAHHATRQLYDPRLDRGNSNRRGGRPLGLAGGGDRAGAFRGRHEPEHTTHHSSAGGRASATTAEVAQPPMGWRNNQFGDDTEQQQHVQSNFSRRASGTFLGRGNFGPRGGRIYEWQSGGRTADASSLDGRPQWQRSKADADRVWSHDKFFEEEQAENKLELVDELNTAAATAAAAVVADGSNNGRGTAVAVACSSSPQFEDPWTGKQLQQMVVTLPSSSTAFNPSAPASAGGGSDHRAVSKPVPVFDDDEAEEELVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUH3</accession>
    <name>A0A914GUH3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUH3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11448.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11448.t1"/>
        <property type="gene ID" value="Gr19_v10_g11448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11448.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24942" checksum="6D7E2597071B2603" modified="2023-02-22" version="1">MVAPRRPGRRNGSAEIPKRCRRPSCSRSCMQLAVWMPKMVPPGLKNRAPSPFIAWCRDYLMHIKRKTDLTPPAGIPGPDGECVYMPPNRFPNTQSSRSIEPAMAQGGVHHKLADNYYLDRDARRDVKPPMPVYKADGSVALLQGAVVGAPTTADKMDKDISAAFNKGPAQNFGLNFPTPGFGYEWEAQRRGRGVLAEEEPGTRQTREVRHVSEAAAMTRELISNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUI5</accession>
    <name>A0A914GUI5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUI5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10904.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10904.t1"/>
        <property type="gene ID" value="Gr19_v10_g10904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10904.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28779" checksum="B2B41E25552D3022" modified="2023-02-22" version="1">MLEFESGFGIGQMKGQKLDSNVENSSQSTAHSTTAASRWDELRKKSARDPAGGLARAHSAGPLALAPQWRSSDFFLRPHYLLRLRMLAVGGPDKKRSTTIGRARLARLGASRLGAHDWARTIGTVGRVTIGRARLGAGTFSVGTIRRPKQTKQNWGRLRLASCVWPFASGRLRLAVCVWPFASQGRLRLAVCVWPVESQYKKDWRWNLLKCVGSDCRWSFHRFCCTSLDSRHNLLFGDIRCAVLAVMFPNGLQDNIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUS0</accession>
    <name>A0A914GUS0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1138.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1138.t1"/>
        <property type="gene ID" value="Gr19_v10_g1138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF485">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE DAF-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1138.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15013" checksum="4ED5207B661B8C26" modified="2023-02-22" version="1">MGRRVEPQFYASVTILYSDIVGFTSLCSESQPMEVVNLLNGMFRYFDQAISQHKAYKVETIGDAYMVAAGIPERIDSHVREIAAISLMQREFLFGYEIPHRPGQHLHCRWGFNSGSVFTGKKKPQNFFIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVS7</accession>
    <name>A0A914GVS7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVS7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11645.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11645.t1"/>
        <property type="gene ID" value="Gr19_v10_g11645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11645.t1"/>
        </source>
    </evidence>
    <sequence length="540" mass="61899" checksum="A8D08401B631BC95" modified="2023-02-22" version="1">MRPTFEAAHRCANDYRPFIKEANALKVLFVQQHYSGFSSHFDFILHLAKCLAEDDGHEVHMLIPIREENYKLADKNEEVQLNVRYFMPKRQMPPSLGFNASLIVHDKIYLDIANDLELMDELRAEKFDVGITEAFRGAGYSLAIFHLLQIPATIATRSQAMAPFHLYLLGVLSKMKTGECIRNSRPSIKAQNKTTPAALLCNYIGLPTMNFWAGDRLELLNFKSRKVREEQLKLRSETIWQHCVKQTMELINDHINEDVEYQKLAEEKYGLNTFPGWDEMFRSARFFFLNSLPEVDFAQFKMVESIEKVKFIGGFNLARPSSFNTNAIEHTNSLINLTLGTKEGVILVSFGTVVDAKGTSSHIIEALVETMANFPNYLFIWKQPKGELPIILKELKLQNVVLQNWINQKELLAHPKTMAFVSHCGMNSVMESTFYGVPMVCMPFFGDQYYNGELLAFQNIGLVIETKNDKQTIQKELNVALSTALGLMKRSEEHFDLDKLKSVSVGIRQKNIVKTISDAMKTIEKEINEKKRQERRNSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWL4</accession>
    <name>A0A914GWL4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MADS-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11865.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11865.t1"/>
        <property type="gene ID" value="Gr19_v10_g11865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="353"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="741"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11865.t1"/>
        </source>
    </evidence>
    <sequence length="783" mass="83736" checksum="354BC3EC3EE67CD2" modified="2023-02-22" version="1">MRPQALVGPLRPGARHNCGIDDVDVIDGRTKSIKLEAKGEGDEGDYIRPQFSGAATFFLCVAMARTLTRSGISAPYLSPISVFFVGILAKGRESGRTFLYPFHVLWPLTDRFSLPALHSSRCRGLPHAPDRPLLCTWSTPHSSVYNIRFIYNSVGVLLQVVACPTKHTPSPHIHRSVAIEQSDLINPPVPVSGYPQLVPFFGSPPSAASSASSTASSTTDPHQQQQHSPVFHHQHYLTALGSAQHQTVQQQQQQRRPYASPSGGGGGGVAFFDQFSVPQQPLHHQHHQQQQPPHLLQPLLPQGAVVAGGGGDGGVRAVPATQPQQQRINGNNNNVNGPKTAVNNTNTGNKRRMGRKKIQITRIQDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNRLFQYASTDMDKVLLKYTEYNEPHESRTNMDIMETLQRKEGKQGVCVDSDDDGFSPPASPSAGAAAAVVGGAALANDHGAGGVSAVNGNGALASQMAALSAPGAFTQSQIATLAAAAQYANGQGSSGGSALTANVPYADFNGVQNIAQQIFGPSSATNMFLQLQQQQQQQQQQPPKIVHQDFASTSPAGSNSCAFNSSVASVYSPNSGSTIHTAASITSGTGGLEHQRSSPMPGGSGGLTSGHPHTSHLHHHQQRPASTPYGTLMPQASCSVAAALPPQSLTPQPHHLSIGGGGTTHMHASQHQQQLHHHHLQQQQQQQNQQLHESWLNEYHQHPGTMHLKAEPPQSPPAEKRPRLDVPSGAAASQTEAWRVATGTPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXH2</accession>
    <name>A0A914GXH2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Double-strand-break repair protein rad21</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXH2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11665.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11665.t1"/>
        <property type="gene ID" value="Gr19_v10_g11665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21792">
        <property type="entry name" value="Rad21_Rec8_M_NXP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049589">
        <property type="entry name" value="NXP1_M-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="7">
        <location>
            <begin position="544"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11665.t1"/>
        </source>
    </evidence>
    <sequence length="601" mass="67893" checksum="3E9F05D7F7A18345" modified="2023-02-22" version="1">MFYAQFVLSKKGPLAKIWLAAHWEKKLSKAQIYETNVQDAVEEIIQPKVKLSLRTTGHLLLGIVRIYSKKAHYVMTDCNEAYLKLKMAFKVAGATGRDIEHRERDQRDAATTNNNANANNDIPEVITDFYDNLPEIHDFDLGPIKDYQPNQSRIDDITLREDRFETSSRSGLDFVADAGAVGGLDDFGEREHLRRSRSRSIFEEMEEEVEQQRRGDVRASGAHSFEAARHSGGLPIGRDDELGQKRTGAGGLELFDNDFNDFGTAEDLDLLFNVDELSRDIDLGGQSAAPAAPGAVDDGDQPMDVDGDGKMPSNELSFQLEPIEPQQRNHERVRQKRKRKLIVDEPKVISGDEMKANMADYRDTIQPIDLAPPTKQLMRLRENGQLEKMLTMPACMDWLLDPGIIRFYQSHLVPHAREANDMALTDELQQDLQLAEHIEEEPPHNNILEQQRLANSPFVDNVGGAVDFVPPLVDGTLEAGGEPPLVDATAFSPPHLEKRQTKRSRAHEREEDDEDEELFTRRTKNVLQSISNKLRANNNTNKIVFEDLFTKGSTRRTAAQKFYALLELKKWQAIEVEQREAFGTIEISAGVRMQETIKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY52</accession>
    <name>A0A914GY52_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GY52"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12414.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12414.t1"/>
        <property type="gene ID" value="Gr19_v10_g12414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF162">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12414.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21755" checksum="AE81E7063D63C088" modified="2023-02-22" version="1">MPMPFFASRAVAAAASVSSPSFCSSASSSASASCLSSPNFLPWHPYPPPAPSNFDPSLICWDFGLIAPPQMPPNAAKQFSSTASNCLPIKGRATKCGTTAAPKTSPKRPKGGANRRYKTPSPQLLRIRRENANARERKRMNLLNNAYEKLRAVVPPLENGQKLSKFDTLKMAQTYITDLDDCLKGKETTTIRPSRRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H005</accession>
    <name>A0A914H005_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H005"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11965.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11965.t1"/>
        <property type="gene ID" value="Gr19_v10_g11965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11965.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21448" checksum="6001B37E5AFE92C8" modified="2023-02-22" version="1">MTFADYIDRDFFRAWPFGVLKTIHWFAPFATLITIGLSRYVYGSIDFVLFTAWNSFIISLITWICYIFRLNRKTFQFGASFVFVPFALIDFIVSVLAVLLFGISSLICAIALIHSLDYTISHTFSYLLTTTFCLISGSAFGYFAILVYRLIPNGQFRHLMTMVIEGRQITSLDGQGGGGPVSTGMPGRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1E7</accession>
    <name>A0A914H1E7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1E7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13032.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13032.t1"/>
        <property type="gene ID" value="Gr19_v10_g13032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13032.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18875" checksum="6B716844D0E41106" modified="2023-02-22" version="1">MDEDNNDIEQLMFDELGDAVEDHKPEGQMAIDDSDNEDDWRDDLHLSESSEEEDDGKEDQMEKEPTREERSPAAKHYKRMGTALRESVAQFAQTAQMMSEAAKRMGDVLEATLTDMAVIQGQQNRARAEAARIDGTRLRLAVMRRDIVRPPGVSPEAPCAAAKGREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1R0</accession>
    <name>A0A914H1R0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1R0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1334.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1334.t2"/>
        <property type="gene ID" value="Gr19_v10_g1334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1334.t2"/>
        </source>
    </evidence>
    <sequence length="435" mass="49556" checksum="49A8DED6ED539542" modified="2023-02-22" version="1">MNILIVQIEVTEIKEINAQPMSGAESAECVRAPKSVASSANEHPETTAHPKSTDKKHADQHPENTILNEHAEQNASSNEPSTSKSMHEHFVEPPEDASSTNKSAIQYVVEQTAFSDELSISKPDHVVEQPETMRKRQIIVNTYELLNEQAAIIVALTDNESVQLQMGPINDYFMKFKQFVYALPDNSTFKIERLLRISKKIEERKEEVKFEEDKAMLEKIREGMNGLETELRDKIATIAEEIEVIGGVVQKVIEYQVGKYVQKEYNYLLTARKNLSLPLKIISEFFGKLELSEAYLKHVEKTIRQIYLSVWTSRRYYVKVESCLVVIGAMISNVSDEVAKNLQIEKVLGRNPVEHLFELQQVAQLEGMPLTEEQVVLLYMSKCLQRAQTLLEKAIKHLKSIENDFCLINSVGIVIKSADALAKLRRNILLMKNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1Y6</accession>
    <name>A0A914H1Y6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transporter ZIP14</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1Y6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12486.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12486.t1"/>
        <property type="gene ID" value="Gr19_v10_g12486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12486.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="41451" checksum="1F8A8B6ED4C29884" modified="2023-02-22" version="1">MSSSTMPSIATAKSSNKPDQATVWILGLSFVTVIGLCAVVGILVMRCLKKSLFNRFITFFVSVGVGSLSGSAVFHLLPHAFGFAHEPHVNGSHSSLTGGPAPDFNYLWQCFAVIGGIYIFFFSDKFIKIVLETRKRSMKKSAEMKQLHSNHKHEGTENGHLVSDTLLNNDQHRVTVTQHSVNENTDISKEMKESERYIEQQTHALCVHDHDFKEGDSVIATVAWMIIFGDGLHNFIDGVTIGVGFNKSIVGGISVCVAVLCEEFPHELGDVAILVNSGMSMKQALVYNLLSAATCYVGFFIGVLVGEIDDITPYILGFAGGMFLYISLGCMMPEMKNAMEKALSVSLSQGLEMLGLQAAGVVTGLVCMFVMARFGEEIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H307</accession>
    <name>A0A914H307_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H307"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13522.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13522.t1"/>
        <property type="gene ID" value="Gr19_v10_g13522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF21">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="86"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="299"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13522.t1"/>
        </source>
    </evidence>
    <sequence length="474" mass="51572" checksum="F813B87C313A97C3" modified="2023-02-22" version="1">MDQVHIDEAPASENRDHSKDENCTALSQCGGKNPPERKEESPRSFIVETVVPFVLAGFSMVGAGALLFHASKTHFIVKMPVVLVLVPALLGLKGNLEMTMSSRLSTMANLGQLDVPLRQLFAMLFSNIAVNQTQAIIVAMIASLVAITTDLLDGNGFDSARSLCLVVSATVSCSVTSMMLTSLMVFIVITARRCGLNPDNIVTPLAAATGDVVSLSFLILFGNWFFKLYEKYLEALVIFFYLVIISLPMWTFVAVLTPATRNVLKHGWYAILIAMLISISGGYILRHAVDSFPSATLLQPVINGVGGNLVAVQASRLATYLHQFGKQGILPANTLVTYANPFRTFACKERESNNAVILLMMSVPGHVLFIGMLLLTGKTNELPNWSFFLLFLCATTLQVATLLYCCQLLCRCLWRFRLNPDLSAIPLLTAFGDFLGAGLLALAFIIHAAASPEIYNSANQQNSTTMTVYPTISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3G4</accession>
    <name>A0A914H3G4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3G4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13295.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13295.t1"/>
        <property type="gene ID" value="Gr19_v10_g13295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186:SF2">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="4">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13295.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12310" checksum="1FBB316E94E69C74" modified="2023-02-22" version="1">MAVADQSQQNSVVGGWTDQDVAGDSVKTLASRSIISAQSQVVAGLKYKLRIVVGRSNCPKSPLTADFANCAEGDQSARKTYLVTIWQKPWEHFEQITYEAEEMNNSREENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4W1</accession>
    <name>A0A914H4W1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4W1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13852.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13852.t1"/>
        <property type="gene ID" value="Gr19_v10_g13852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13852.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15584" checksum="D6FF669A7B2FCD2C" modified="2023-02-22" version="1">MPILSLFGGGSAISGEGSGAVVQQQQQQQQGSRGVSSGGVVRRRSWRVHYTRPKKNKSFEYETSTGSAYENGRLLIPRWTHWCPHAIRPTGASRHGRVGQSDRELADLRCGWSRADTNAAEWEEQGSTTTDHPLIKHEDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4X1</accession>
    <name>A0A914H4X1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4X1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1369.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1369.t1"/>
        <property type="gene ID" value="Gr19_v10_g1369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037042676" evidence="1">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1369.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8607" checksum="EFE160049E712D8E" modified="2023-02-22" version="1">MLFFHLAIVISLLAPFGPGVEGIFCCQPCYNTLVDCVQNCSIDPHQTNRTLCANNCGRDAMNCASVCGPLCPLNKNSTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H583</accession>
    <name>A0A914H583_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein BCCIP homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H583"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13352.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13352.t1"/>
        <property type="gene ID" value="Gr19_v10_g13352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13352.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35176" checksum="D644DEEE5B869669" modified="2023-02-22" version="1">MIDQNLVEFRAFENIDVCGGRHCIIFENVCGDGEEGRKEEEEDSDIVEEDESMSEVEDNPTEEMTKLHFEFEALPPAEDDLEDIERLLTQIFLQADIDKQELAKVVADQSPLGCVFRPVEECEDEEIEAITYGVLSIVPLSGTKKFQSDVAEFILHRSKKHSIGEISRIAGPAFHSLDADYKSLPEEERFEHILVVLKVRICTEQGSSASSSQNVGKKPKLGKAARKRLAADGTAESDIIFDNPEEQLLFERTFDFPHFQYPVESEIEKTSKFHSIQRGGRTYRPFRRVCLLNNDQFLAFAASVTRSYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5L2</accession>
    <name>A0A914H5L2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCAN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5L2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14390.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14390.t1"/>
        <property type="gene ID" value="Gr19_v10_g14390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057560">
        <property type="entry name" value="Znf_SCAND3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23663">
        <property type="entry name" value="Znf_SCAND3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14390.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25215" checksum="1C115A776CED2016" modified="2023-02-22" version="1">MESICCVCKFNYQGSHCCSSCKMPCHAICGDAGDEEGYGAQVVCFNCKKSVATGDDEKDDNEPQFLKELGVEAAYIPGGCTKFIQAPYVCWNKPFKERIRHYYSLWITNGDRQEYTAAGNPKAPALEVVLDWVDRSWQELSKEMIIKSFEVCGLATTSDGYGDDRINCFKPDGSIGTRGIDLLREFRGKETMKDGRNDVEEAGLSEDENNVELSGVGEDDELFFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6X8</accession>
    <name>A0A914H6X8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6X8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13788.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13788.t1"/>
        <property type="gene ID" value="Gr19_v10_g13788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13788.t1"/>
        </source>
    </evidence>
    <sequence length="678" mass="79380" checksum="450EC90C6EDC520C" modified="2023-02-22" version="1">MPPKRQNEQFVEESQKQTFGDSSKDNNNGARKFKQEKPDNDVIILNDDYDDDRKPLLEKPALTKRGRKPRWDKQQQEQEELPPKKNSGQRKRWYSKIAGLAIYSLQATKRYGTFTFMCKDCQTANFQMGDRRFMLTPQNGEGRLEFTQTFCRDCAKLNFDCTDLIMKHQKKDAPTKNGHYHPYTGGNNTPGFVGNKTNKFKVHLPKKLVFEGPGWMVGMSGIIYPNSWATVGTLEKQYVIVHLRDGRKYRFKVPRGSFLSPQQLERGIHHGMIAEMERLMTRKRAAFQEDEEEEGELVDVQVVEEEEGGLTGLQVAKEERKESVEAPLLPMSQTKFASEQAAERTRQPPLANVRPPEQRGAVRERELVPPNETERLAQEKENERKRKAQKWIEDGRKETERRRQEALRKETERLQRMKNATKEGAASKKKEEEKLGTPKQAPQQAVNERLENQKEEERLSKQKEAAEKKEEDRLAKQKEETEKKEEESSAKQPEDVGNRPNNGIERAVNPAGEEERIRRDQERKFKLRELELLKELKPYRGGWMRLVQGKDPTPDVHYLHEKDEYHFSNAVDKYRIHHPELPWELPAFNPSAQIQRNIAEFKGLFEREVYDENYGSKTREEKEELIALVKGFRFYYMEDIFLAEKYLYRRVLSVRIARSATAAFFFELVSNFWMPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6Y0</accession>
    <name>A0A914H6Y0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H6Y0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14753.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14753.t1"/>
        <property type="gene ID" value="Gr19_v10_g14753"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g14756.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14756.t1"/>
        <property type="gene ID" value="Gr19_v10_g14756"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g14771.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14771.t1"/>
        <property type="gene ID" value="Gr19_v10_g14771"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g14780.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14780.t1"/>
        <property type="gene ID" value="Gr19_v10_g14780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14753.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14756.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14771.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8591" checksum="8971E27367E5F695" modified="2023-02-22" version="1">MSDQPMAPLGKYPQPIDCPHCHKKTTTFVRPVCGLLAWLLCIFLAIWCVCCCDSFKDMEHYCSQCNGFVGKYKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7A0</accession>
    <name>A0A914H7A0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Trehalase</fullName>
            <ecNumber evidence="3 7">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3 7"/>
    <dbReference type="AlphaFoldDB" id="A0A914H7A0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13872.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13872.t1"/>
        <property type="gene ID" value="Gr19_v10_g13872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037368367" description="Trehalase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="736"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13872.t1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="123290" checksum="D19E20187A48408A" modified="2023-02-22" version="1">MPWFPPFVRPLLFNFFILGLLPLFSPVFSETLYLKKQFGDNEHTVEEWGKMDCSLNEFDLTALGLERSCEEWPDLAPIYCDGKIIEAVNYWGERMLFLRDSKHFVDRPLKKEAKKVVEQFKAMFNVTEWKKFVVSDMSPAQVDQLSKFVRENFGMADESPIPQPGALLPHVPEDWVETKPFETIKDGKLRKWAKQLNKMWKEMSRKMPKEMNGKGNQQNSLIYVSNPFMVPGGRFREFRYWDAYLIARGLIASGMTASVKNMCKNFAEMVNRFGFVPAGGRIYYNKRSQPPFLTLMVYDYFGATGDIKFLKEILPVLEKELDFWRTKRSIEVDVKGRKKTFYQYRADTNLPRPEAFCQDVNLVKNISDPKEKAKVWRDIASTSESGWNFSSRWIKKDETDKENPWKLTNLMTTKIVPVDLNALICGNLEMLAHLYLQIDDKTKSSEYHRKFQLFLEDFQSLFYKKEHGIWYDYNLESGGLNEMFYGSAAMPLFARCYHTVDVDTAERMFRRMEQFDKDNKMLSHPFGVPASAVNSAQQWDFPNVWPPLQHMLIDGLRRSFNSRMEDKAKELAQKWVSANFKLYQNSQSCGKKMWEKLTADGGTPGSGGEYSVQIGFGWTVGAMLDLLVTYGTELTAKGVAEMKCDNKIMEAEPLEFPNELTEYRSELLTEAQKKVDEINKSQKDWTAVVYEPFALMTDEEFKQLLGADLEVTNGPYNRQQLQWKGNFEVEKDYKDLPKEFDARQKWPECADIISNVPDQGRCGSCWAVQAAATLTDRICIARLKKGQKTDSKDPRAYVSAQYTLEATPESKGCKNGTNPRFAWNYYRNMTVSGTNYEMYDGCKPYTIGPIAERKWWYFINPFGSLTDDASWKTREPNCNNKCKERYLKRQFPDGQRPWEPFIHEASIMPAVTDPVAWISWNGKWGEKRINGQSLELEMMREIMANGSIQAGFEVFDDFKTTFKNDRNQIYSHSPNSKSMGRGHALKIIGWGQLYWLAVNSWGKSWGHNGMMKIRRGINEGGIESLSVHFGAVNCGIRRLRRLLPQQFCPWLRFQCLFNKMCSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7G3</accession>
    <name>A0A914H7G3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7G3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14908.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14908.t1"/>
        <property type="gene ID" value="Gr19_v10_g14908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037756323" evidence="4">
        <location>
            <begin position="30"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14908.t1"/>
        </source>
    </evidence>
    <sequence length="421" mass="45489" checksum="3F41391DF1B3D094" modified="2023-02-22" version="1">MPSGAMPLPSLLLCSQILLQLLLQHIVHGFSVNQKDCQANEQFLQCGTCEGSCKEPIIANCRRECKPPRCECQAKNGYVRANDGACIMISECVSYKGIYFGKDSAISVTGVDTKAPKTMLNQFKTAAESDATGGPVQLGKRKQTATAAGGADHPPSIRPPSANRHPIAPHTLHDNVIQTGPSPVIIRPTAGDGHAIGRSRMNLMADVSNAREDTDSTTAAGEERTVSAVEHRSVHSIKNKQTLNSVIHQRSAEMDSSRLTSQEQQRAADLSNNGNPADTFSSIPAFMLDERANEGSKSAVLAKCDERRCPVTTTANDDRSSAKHQQQYLSSRQKLMNKNHPPYLFAYINSPAAVSLKEEAVEVPPVASDLNSGLVDVPQGELHSENAGTDGTWPMSVARDERHLMPAAIPPLPTNLRIFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7L5</accession>
    <name>A0A914H7L5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7L5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1476.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1476.t1"/>
        <property type="gene ID" value="Gr19_v10_g1476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1476.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16043" checksum="DE0D6E6BEAA127FC" modified="2023-02-22" version="1">MKRARPSQEFPEIEFNVNTMGLTVYCPRHLKTPRLVPWDQPGRCSRCRSGTVELDYFIQAEGVTVFSTRLKNGGENFVPFDEIVDFGDNAKFRIRSRNKVFTLPLRHPEVWQAEPVAGASQVLAAQPPAEETKNGEEPKGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8Z9</accession>
    <name>A0A914H8Z9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8Z9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14354.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14354.t1"/>
        <property type="gene ID" value="Gr19_v10_g14354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="388"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14354.t1"/>
        </source>
    </evidence>
    <sequence length="583" mass="66326" checksum="93F8BA341E1913ED" modified="2023-02-22" version="1">MSNLILSVYLWPSFAQPNAELADELAELAQRQQTDSPSPTESGFDLVSTAGGQNDEDGTGFGHAHVVATLQHDQLSEHQQLPTTNGQPTGKKKCLAVLQVQRVDKSTTYCPSLRYEFFTTEAEPFCASSGTEHGNPTVGHMTRAILSKHLPMSMEQLASHFDLKVQIRERAFMPDTVYIDIDRQQCWTEPVEHLGEYKVLLHPKLGDNNVGRIVRGQLANLQEKIKQMELKQLKELIAKREEYQNKQQQTIDALTVKLKVSIDQFSLKHQEHEKLLNDHQKLMEEMKEQRKMDALRQQKHQKETNDKIGWLNEDQQKLVSIDHFLLMQSDQKALLERIDGLEQKQTTNTEQQKADQKALSATIDQGMSQLKGEVIAKMGEYQKEQQQNIDDLQKTVGTLREIGLTLQNRWDSAACHKDLALSEPDRLIVQSIGGSQCHRSVFAVEPIPKNPFGIFYYEVTILEEEFFVFIGLAPKQMQWDKYVGYYKGAYAYECFGKFWGHAVEGCSYKDGRPVIGRKPWFGIGDVIGCGVNLATRQIIYTKNGRCFETTGLFVDSAAELFPCISLYFGKIEANFGPDFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAI6</accession>
    <name>A0A914HAI6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAI6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15573.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15573.t1"/>
        <property type="gene ID" value="Gr19_v10_g15573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="606"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15573.t1"/>
        </source>
    </evidence>
    <sequence length="903" mass="103139" checksum="0B88941DC8DFB4D0" modified="2023-02-22" version="1">MFKNNFRYPKQQQQLLDEQCKYLFRMANEMKDDEQRFNFVHGHICAVEEGMREGEQKKKVVKSMASWALKEFNAKDGYKMDVRMLDFWKFLGKYSDELKMEGVMENVHRLGHFKTQPAFYLLWAEHWASLGNRRNFDRTVTMCENNCSIDPFECKELFKPLVCKYFGEPSEETSNTMALIKVLAERPDDMRRTLTMFPDRTTINLRTRNIVEEQTTKQKSLEQQQPLVTSQEEFSIFQDPTTLVALTEVAKQQQKNSENPAAAKQMRGAAASTSTAATQPKSAVISDERAESEREKPPSSREDFSVYREPTITRQIEPSKQKEVAVVQPSFMSVEDDVQLLGHVTGKEPQPLQSMLCGDVDDITLSGAHGKFAPNVFTSTPRRSVAFCAFDPLLMEMDDDDGLIMEPPTPSRNDRIGELFAPVSDVGGSKLQRRLSLAGDFPTHSEKLSTNQIVGPRKSGNDILKAMPPLKIASTIAEETEEEEKENSFVSPYRKKQRQALTSPCPASNAPHIQPEPMPQQLPQNNAAQSSEVLAQPPETHFNPDGTHLGTVIEKIKTGTENPWDEEKRKRVLRAAHVMVECHDFLYEKCPRIEVNRATDLGGESFYVEKLLGQGGFARVYKAISRENCQAYAIKYEAPACPWEVYICSVLKQRVPSKFVAYLMEVRDAYIFKNASAIVYDFYPNGTLLDLSNVYRRQGAEMSGLLATFFGIQLARALQQVHQMANIIHADVKPDNVILLTSSLNDRASLEELMNTPVLKLIDWGRSIDMDQFKGIEFVGKAGTENFDCVEMKMGMPWTFQTDFYGFCATMYVMMKGEYLVTFKYSHTDKIVPVKQLKRRMALYDLWTQLFEQFLNIPDCKQLPKWSSALRCMEDRLTEAVKVEPLEWKKALERFNAFAKQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBN8</accession>
    <name>A0A914HBN8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBN8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15123.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15123.t1"/>
        <property type="gene ID" value="Gr19_v10_g15123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15123.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14749" checksum="D7B9E65FA22D5379" modified="2023-02-22" version="1">MVARGYAVMGIKWLPEAMPLCRDGNQMVARGHAVMGIKWLPEAMPLCRDGKQMVARGYAVMGIKWLPEAMPPCRDGNQMVARGHAVMGIKWLPEAMPFKCRICCELSFRVLAAELAHIIRLLWPSWARICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCF3</accession>
    <name>A0A914HCF3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCF3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15822.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15822.t1"/>
        <property type="gene ID" value="Gr19_v10_g15822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="109"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15822.t1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43119" checksum="BA77CAF0B022E80E" modified="2023-02-22" version="1">MAQSLVELRTFLSDVTRPDVQLTALKLLLSLSSDSDFCQHLSDMDANSNGLIDDLLRLCSAHQTASSLPILLAIFINISSHSRQIAAKLTESDTFVKQCLLSNAAISVRSAQLLSNLSHFCPTRLHEQIFEHDSCFLSRIFDLLILPPTEENKANATELPETFFGYLLINLSTAPSAARYIAANHLTQLMALLGRNVPMSRRAAALNILFNLSMFDDLHELLLRDEDHLLSSLLWPLIDSEDRLDEDEIARLPIQLQYWEGSRNNSPEIGDKVLRTLYQLCATRHGRQCLRGKGIYALLRELDRATSAPGGRETVGEGRICTFIGSDEGAWGSPGADNELGYAQVLRALIGMLIRSEGEMGVAEECLSIRHLGSADRLLEKVGTEVGDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCQ9</accession>
    <name>A0A914HCQ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCQ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16152.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16152.t1"/>
        <property type="gene ID" value="Gr19_v10_g16152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="SAP" evidence="8">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16152.t1"/>
        </source>
    </evidence>
    <sequence length="428" mass="49565" checksum="7F47D00F1D7D09FC" modified="2023-02-22" version="1">MLNPIPSNSRTEYLFRFFESMPEKELRDELQKASLNQSGSRKQMIKRLRDHHREPLVEHRKKNHRHFLTENVYDYFIAIDFECTCEKGEYEYDHEIIEFPAVLVSVRSKKIVDTFRAVIRPKNNSKLTKYCTQLTGITQKMVDEANTFPEALDMFRCWMAKHGLDGLHNKGGNCRRFCYVTDGPWDIAKFMQADCIKWSMPIPHDFRAFLNLRRAFVNFYCHVRPGNPNPARLPNADLGEMLKRLGMQFEGHEHCGMDDTFNIARIVTKMLKDRAELRVNEKLVNSARLLPWHRKQLIFTDEMWERQQQKQQNAATKAPLMTSTGPPSAASAEDIICAGMAKVGIWDDDDGGGDAKQNGTTNDDKLETNGTKGKVIPEKHKWWEALPYKLVRISREQFLSEVFLECESCDDDGEEEAKTLHNDENGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD30</accession>
    <name>A0A914HD30_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD30"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16390.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16390.t1"/>
        <property type="gene ID" value="Gr19_v10_g16390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF60">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="602"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="777"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16390.t1"/>
        </source>
    </evidence>
    <sequence length="844" mass="95085" checksum="36EF682D87F38BDD" modified="2023-02-22" version="1">MPRVALIHSLFCAGRQSQLSVQCALCRFQSTIRPHSLPIKRVTHAKYGGRYTVTALPGDGIGPEMLAHIRRIFRFANIPVDFEEMELSSKDPANEALENAITAIERNGLAIKGNIETKFDDPTYKSRNSFFRFANVLHCVSIPTIPAKHHDLDLVLIRENTEGEYSGLEHESVKGIVESIKIVTRRNIERIARFAFDYAILNNRPQITAIHKANIQKLGDGLFLKVCKDIAEAEYKSEGLQFNSMLVDNACMQLVSCPQQFNNGILLMPNLYGNIISNIACGLVGGPGLVSGMNIGEKYAVFETGTRNTGTSLVGKDVANPTAFIRASVDMLRFLELHSYADKLSDALYSALTEQRTHTPDIGGSNHSTEVVQAPEEKISEKTGIRMYFLIPTCSAVPAAADSSESKAGTSLNVDNESVVCADELAIPQKEYQICGNDVLGLSASNNNSTEFWGYNDGLGNFSFVCMWVGCQQRLKTLDQLEAHMDQHLSEYGAEPLTNIVCQVQSCQILVSSTEELARHMKMHIFHANRILRGFCVVRERCPKVKSCNFAKTSRLVYQGDPLLCEWNSCLEGFTDINEFIEHVELHIQLLPSGSRSKDGFYGCLWNDCKASFGNRTHLLRHAQHHSGDKICACPFCGAFFSHTAGLIKHVFRRQNGDSSLICRFCQKTFADEALLRKHCIRHIKTHKCHFCSSRESAQSLLRLLWKGVSDSMLRCPKVLTELNFGFYQRSDLNKHVELHFNDAIHECEQCGQKFRWSKQLREHARQHREGFNPTPYECHLCNSRYARGSALSKHFKTVHQMPVPVGFSRFQYKKCQDGLFRLQTKCYVRDNLPTNEEEQNECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD94</accession>
    <name>A0A914HD94_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2 subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD94"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15558.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15558.t1"/>
        <property type="gene ID" value="Gr19_v10_g15558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="7">
        <location>
            <begin position="94"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15558.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26485" checksum="991C4322F401EE90" modified="2023-02-22" version="1">MDPSEQQPEEAEDEVLDLDKKKKKKKSKKPDLKLSDDELEEEKAVTALAEGIGRTNLLDAKDADAWADYNYDEMLDMVFSIMREKNPEMVSGKKKTFVMKPPEVQRAGSKKTAFTNFTEICRLLKRDPKHVLQFLMAELGTTGSIDGNQCLIVKGKFQQKHFENVLRGYINEYVRCHTCRSSDTELTKDVSRLFFIQCKRCGSRFAVTSIKSGFTAMVGKRAALRRAAEATAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDR4</accession>
    <name>A0A914HDR4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M16 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDR4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1569.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1569.t1"/>
        <property type="gene ID" value="Gr19_v10_g1569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="2">
        <location>
            <begin position="173"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1569.t1"/>
        </source>
    </evidence>
    <sequence length="925" mass="103993" checksum="5CFCFC4456C15DBD" modified="2023-02-22" version="1">MVWKKAAEILIDGKVPLTIYHSNRSKLRVLVAETPGPIVDGRITFVTETHSDDGLPHTLEHLVFMGSELYPYKGMLDIIANRCLASGTNAYTDQDNTTHLLEPTLTQSQYMTEVHHINGSGHDSGVVYSEMQDRESGMETMVDRKRKQLFYPKGSSYAAVVGGALSDIRHICSLERVRAFHNNFYHLSNLYITVCGQIDHQKLLDVIDPVEQRNLDSVPKHFAPPFQARIAPLTGPKTERIICPSDDESIGMVEMSWLGPEIGDIHTTRALMILFDYLTDTAVAPMRKDFVQAEDPFCTSVDFHILEQRDCEIIASFEGVPVNKLEKIREHFFEKTVADHRLPDAFDVQRIGFILDQQTRLFHSKLENRSTSLIGGAIVGHQLYGQESDPDYKVMEQYLNEADLLRKFKSLPASFWHSLFHKYLANRNCVCVMAEPSEKMVEEHAEKEEERIKQQIERIGGESGLAICQKNLEEAIEANTCRRPLDDDLKEFIVRDFEKFNMIKVNTSTNLPPHSNGFACNFPFTAIWHGVRSDFVDVNILIDTDGLPVEDRHFLMLWFELMFQSPAVVDGKEISYEEVAKLSTRDLVSNSASVGVSGVYDRFLSLRLRADSEKVGNLSKWAYIYLKGIKLYPDRVAICARNLANNAADSKRDGNSVCHFLNANSTYSTDSNTRFYSYLGLEKFHKAVAKAVADGKSDAVLARLEAVRQKVLTSPLNDRRRMSQRNGDSSGSKNAHFYNAPPTMVPAWNTMAKAVPLQVGGSESAFLLQKTRFDDDWTGPTTMPTLLLAQYMVQSEGPLWCAVRGPVHGTLPLLPTGPGLRKNAGHSDFRTGRGQSTVKLTATSAILATIRSVGNDFTLKLCEQIWHAKAADVLTIGSPALRRLFDPSKSVRSIALNPSRLKELREHFPETNMVRLEDFQVKNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE65</accession>
    <name>A0A914HE65_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Immediate early response 3-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors. Acts as a regulator of the unfolded protein response (UPR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HE65"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16527.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16527.t1"/>
        <property type="gene ID" value="Gr19_v10_g16527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16527.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9104" checksum="2006F4D7EDEC842D" modified="2023-02-22" version="1">MLSLFTMLEFSLLVLNGIAIINRERVLNKYLMNRQHGFGTESDQSVVFRLVHLILAIQTVLRVPLIALNIFVIVIKLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFC8</accession>
    <name>A0A914HFC8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CLAVATA3/ESR-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mimics host plant CLE extracellular signal peptides that regulate cell fate. May play a role in the differentiation or division of feeding cells (syncytia) induced in plant roots during infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Host extracellular space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLV3/ESR signal peptide family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFC8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16101.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16101.t1"/>
        <property type="gene ID" value="Gr19_v10_g16101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043655">
        <property type="term" value="C:host extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044962">
        <property type="entry name" value="CLV3/ESR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36349">
        <property type="entry name" value="PROTEIN CLAVATA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36349:SF2">
        <property type="entry name" value="PROTEIN CLAVATA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037594235" evidence="14">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="116"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16101.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22986" checksum="493FD59640A9255D" modified="2023-02-22" version="1">MAKNAMLCLLILRVVLALAFATNKKGDEEPENHSTGIFGKVGRVVTVALAMSSRLGGADATRGGGAVYGGNLKSNQLPNNNWMAPPPPMAIRSAKVYDSKHSPAKYLKKFAQDFRRKTGMHSQRHHEETTLEQEKRVAGAGPDPIHHQDTTLEQEKRAVPAGPDPKHHEETTLEQEKRAVPAGPDPKHHEETTFEQEKRGAPAGPDPIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFE1</accession>
    <name>A0A914HFE1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFE1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16860.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16860.t1"/>
        <property type="gene ID" value="Gr19_v10_g16860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16860.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25980" checksum="1F2D66DF22F5AA40" modified="2023-02-22" version="1">MAQRRRFRRLPPELTNEIIHFVIGTFCHRRLITSSALVFHLLRESKRGKHWKSEALNAREEAAEYGIGEAARRALITRLTLHRNTAAFAWALFRGELEDRYELVDDEFNIRYLISLRARNPANARQTVRAYFQSNAQQTFIRETFRCAFEFHELDHPHVSWDIAAVTWETDMAMRTNWNSLMAYIRSRLNLVESGLPLPPPELGQQEAEGDSSPEADSPPSIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFJ5</accession>
    <name>A0A914HFJ5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HFJ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16897.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16897.t1"/>
        <property type="gene ID" value="Gr19_v10_g16897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000157">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="91"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="369"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="469"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="743"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="892"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="925"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="97"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="475"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16897.t1"/>
        </source>
    </evidence>
    <sequence length="947" mass="104557" checksum="7D11430C387E07E6" modified="2023-02-22" version="1">MPELPNLKRTTALLQMPCCPPSTSASSTMSTASSVEPPVAAGDGDDVKQSQNGLVALNNDGQMGGDDDDFRWTMNGDDNDGDQQKVSMENFALIKVLGKGAYGKVFLVRKVGGHDSGSYYAMKVLKKTRVSQKQKTLEHTLSERKVLERLKGLPFLVNMVYAFQTDTKLHIVMEFVRGGELFTHLCKRKKFDVSTTRALLAEMACALQHVHAAGVIYRDLKLENILLDEQGHVKLTDFGLSKAFELQQQQQQHQGGDAPQLTKSYCGTIEYMPPEIVRRQPEGYGQCADWWSFGVIAFELLTGCSPFTVDGNQNSTEDIARRILTKKVPYPKWMDRTSRDFIGQLLNRDPKLRLGARGAVEVKKHRFFDGINWEAVERRQTAGPIKPSMAGGVADVENFAAEFTAQTPLFSPADKPPAECHTFFRGYSFVSPSVIFASDNVIGQECLEASVRLLSAQSSPFFANYRLDITAQGLLGKGSFSICRRCERVADGRQFAVKIVSQRFAHQARREVRVLEALQPHAHIVPLVDAMSDAFHHYIVLELLEGGELLQRLRRMEKFTELQAAEIMAQLVAAVKHMHDRDIVHRDLKPENILFERDQPGHVAPKLRLVDFGFARILPRPSSSSTVAQSLITPLCGTLHYAAPEVLDIEDELPQYNQQCDLWSLGVILFTMLSGKVPFHAKSQAESAADIIARIRAADFSFLDPVWTMVSQSAKDLITGLLTVDPTRRLSLAQLGAHPWLRAGRNKSSSSSSSASALASSDMPQCGGTELPTPTILPPSADETFNATMSAFLHANRDGFQLMDVQTAPLLVKRRGMKRQRGQETTDGGSGVDEKMEQCPDGMKLCTVPEGPEHGEQSKRRPTTLDLFGTGIEEQQQGTPNSAAFTEYRDTKPPYLKYSRDDFARAESGGTARHNNNIASVNEPSSGCSSLSGASTIRLSNDSNESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGJ1</accession>
    <name>A0A914HGJ1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914HGJ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16414.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16414.t1"/>
        <property type="gene ID" value="Gr19_v10_g16414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="8">
        <location>
            <begin position="25"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16414.t1"/>
        </source>
    </evidence>
    <sequence length="531" mass="57279" checksum="7B4885C4B2F4D40B" modified="2023-02-22" version="1">MADVNPQQLDPALSAEKAPKKHEPVIVVGGGLAGMAATLEALSAGAHVILIDKEPMLGGNSAKASSGINGCGTKVQKILGIADSPEKFYSDTMLAGDRENNAVLVDVLVHESTSAVHFLIEQGVELADINLCGGHSVPRTHWLLSPKEGKPLPVGVAIIRAMKSKLDEWKRSNPEKFEVLLGTSVLGLVTWNDYVTGVRVRGEGNKISEINGKAVILTTGGFSSDRDNETSLLTEFAPDVLTLPTTNGPFATGDGVKMARAMGASLVGMKRVQIHPTAFIDPKDPSAHTKFLAAEALRGKGAILINENGKRFGNELGRRDYLTEKINKNCARQKSVGDLPVAWMLMNNASADSFGRPAFNFYAKIKGFFTAFANADELASAIGCSVEQLHKTFAEYNEYVEMSESDEQFRDPFGKKNFPFKFDPGQQIFAAKVTPAIHYTMGGLQIDKKAVVFNEFMGRPFQGLLAAGEVTGGVHGNNRLAGNSLLECVVFGRIAGQSAAEIDYQSAIDVQFVGRNSFVNEHTEYDEREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHT7</accession>
    <name>A0A914HHT7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HHT7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17293.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17293.t2"/>
        <property type="gene ID" value="Gr19_v10_g17293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="867"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="908"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="947"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="996"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1038"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="700"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1142"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="717"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1143"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17293.t2"/>
        </source>
    </evidence>
    <sequence length="1174" mass="134577" checksum="E234DD8EE0573D2D" modified="2023-02-22" version="1">MEFVLQYCLFNNAPNSTNFWLEKIQWLQSRAHNLWMRRDKMNDQETSTSSSFIEPIIAPVQRKEKTLKDRIMESIMFAHEEEDGQGEKDICRVCRLSGSDTLYHPCLCTGSIKYVHQDCLLQWLKYSKKDVCELCNHKFSFQPLYRPDMPDRLPIWDLLKGVFLILANFMRLTLTYAIVVCCWLGIVPLMAARIHRLVFSGLISAFFSSRIFQLFSTENVAIDIAKGSLVVTIFLCTFISLVWLREQIMIGGPAHILHLNEEQPTTEGQQQQIQQRNREGPNPGASTEHRDQSQERAEQMANGPSTSEAENDPNQLPQSRQPRPLHVYQPVQATALAANHNQPAEGQQPQNGGEAAAAAEIDPQHQRFVDELTWQKLLGLDGSFAFIEHVFWTISLNVVFNVVFLYFPAQIGSGILSTIGFVAILMHGLVIHRIAKIFRLRSLYTAAGMFCLMLKVFLLVIVEVVFFPILCGWWLDVCSLPLTGITLEERIRTFKQYPSSSMFLHWLAGMVYVFYSASFILILRELLRPGVLWFIRNLNDPDFNPIQEMIEQPVPRHFRRLVTSITLFFSIILLVIYVPLRMIKWLFPATLPYVFSGSADTPLVEYSFELVLLQIIMPSILEYSKAFSLLKRAVRFWCRVVGGWLLLDSYLLPADKDKRNVGQQRRDQQRQRARERMLRGDQGEQIGLLEALEAIEDNSTDDEALENDNNGENVEGLAEDVGNETGSEQDENEGVEEDEPEKLEEEAVDNEVEDAEWANENGGKTNTPTEVLEDLKQQKGRLKRRRSGEGSAEQNTDNALEENNPNERVLVREVQRRDRQHVRRAQAQHHREQRNLGAQHQALLRFRDASVPEDYVQPNFFPLRVTLLLVFVALTAVVISLIFFLLPVTIGRFLLSILALTNQPVHDLYTIAVGLYTCWICVRLGLLSREWARRGWVYMKKLFNATIFLLVRVIAAAFPLLTVIPLMLGLYFQMLVISPLRVAIFQSPLFFPWKEWAMGVVHFKIVCASVLMGPDWWLKTAFEQVYADGIWNIRLWDLYVNLVFPIVNTLAFLIAFPYALSNFVLVFVDASREEQVIATRFAYPILLGSICFCAFLIWQWQKLKLLAQKIRNDKYLIGTQLVNFYRENTSAVVGFTTAKISLTPPTQTPDPQQQQQKTPDVAKEGLPNTEGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJI9</accession>
    <name>A0A914HJI9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJI9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17472.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17472.t1"/>
        <property type="gene ID" value="Gr19_v10_g17472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13401">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13401:SF2">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17472.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22372" checksum="F5D577A9679BAC93" modified="2023-02-22" version="1">MPLPGFIQTLRKYCCCKGNAAMDYERLVAGGGQGEEYTAANSNGAATFTGSARAGVSESGTVSQSRSREEEEEELMNKILDRTQQSIIDVTNLENGSLDFDLVQRSRLYSEAVKRHDSATERRRGLLSMDGGADSDVSHATAAPFLLANVGSLAVELLTHHIGPQMTRDELALLSRVGELFLDAHKLGAQIECKDELIVYMSWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJN8</accession>
    <name>A0A914HJN8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJN8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17803.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17803.t1"/>
        <property type="gene ID" value="Gr19_v10_g17803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17803.t1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43661" checksum="38FC66E20DC3CBD4" modified="2023-02-22" version="1">MSFLTNSNRRSSPQSERAGRTNDKAKIVVQSFKLGSSAPTKMTEYPRESNGKLKEIEVWSSSVFEWFGRANVSKMAPINALFDVLVDSHFGMNRSIGQLEIWRAWNHEGPEMINRFEDGFYRRLSIPQMSPPDNLIGFKSICIRYIDDTVVEFLHRIRHLFDTDITLKLIIWPQSNRAWPAMAQEIWPLVMANVSRMYLDSYVLGRLRLFMSPTALRDCANLRLIELDGLFPEGPADDRAHASDGQALSKWLHTARADGRPKLLKFEGWTGQYHAQIEQLQGAFLVASTPVNYQISLFMHVYGDYEPFELENGKTRERLTFRRAGNGQALWLLKRTLIDQKDEEEEAEGKTDWTWTNGGSLVKVQFEDRDIGPLTTAAHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKA8</accession>
    <name>A0A914HKA8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKA8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1914.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1914.t1"/>
        <property type="gene ID" value="Gr19_v10_g1914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037539954" evidence="3">
        <location>
            <begin position="28"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1914.t1"/>
        </source>
    </evidence>
    <sequence length="635" mass="72228" checksum="3D3441324FE23054" modified="2023-02-22" version="1">MPMHYFFSATPFIILFHFLFSVPVAKASTDEDDLFVAFVKNERNFAEFRMELEKQRALKKFYGKLEDDNNAFSISDQTNSFLIKMYMAHLGVMYLMRENWQCANSVKQIAKYHQTQCETFRKYLDILYEYLFRIYASGTEAAAKLPDVKPKFIVHNGKIGTLIEILAILSNISRFFFDQNSNTNDYEEPMLSNEGEMNYKSNVANANDGTLRNQFDQKLMQMLMNTAQNEATEMTALNRFERTVTSSGEKQPIKNPLFNAFGTFCEQFGQKHKQMKQNEAKEKAELKKEQQKINAMHVEVEAKEANLWYLPPAEQHKAFCENYKMRLPVMDKQMEQIYKEIAIENLYGGTNRMLGAYLPLQQQQGSYPRGGKGTLLVFTRRSDDSAVDVSAVDGSAEDISAEDVSAVKGRVKKITAETSSAELSSAEPYPAETSTAELTVQLPLDLMWKQFHPQGYTPNQMNFGGFTGGLPLTPYFQQQQYQRYQQIPFHTKAWFNPNIDRMMNRARRRLLPENVTTETESGTSLFNSVNGNSCVICCSASANFYNPPCGHIFMCDGCAVLTVLNKTTSTTKTHGVHVKLCMPKQLIGVKAEQNIKAKTQKRREEELRIQKTKLTAKKKPEIEEEDDAGEGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKR7</accession>
    <name>A0A914HKR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKR7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2384.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2384.t1"/>
        <property type="gene ID" value="Gr19_v10_g2384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2384.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15445" checksum="196DCEC990CF411C" modified="2023-02-22" version="1">MAKSGWEQWRCVNLDLPGLSRNKCLGIATMIDPRYKMKFFEAYLTDSHRKVLEQAAAEMSRQSRKVQKMLNRKNEDMTHTAPGFEPDYITKFGPTHTVNCSSRRVPCRAASVKGDNVRELIFLQSNLPIVDFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLU9</accession>
    <name>A0A914HLU9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLU9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17832.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17832.t1"/>
        <property type="gene ID" value="Gr19_v10_g17832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037365442" evidence="2">
        <location>
            <begin position="20"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17832.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="27906" checksum="FD485F00BA33E21C" modified="2023-02-22" version="1">MNIIAILAILELFICGAWGGIIFSKNRSKPPPSESGPDADTNSAAKQKDGTTNEFARRQRTNKNLTAFLEAQKYCKQLASSIRISAATKSNSASSSSKSGHGESSDKSLAKLLGPEDNSPPPPSSLPLCISGAKSKSAGSSSRQGELLATENNSPPPSSSLPLCFSGAASCGAVIKQRSRRTSSQKSLEAITEIDQNSSPTSSHSRFTDNAVPRESSTIDRSRRTQSHPSLGELLNARRKSEADSNSMDTLWEPMNNGIYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMA5</accession>
    <name>A0A914HMA5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMA5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1874.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1874.t1"/>
        <property type="gene ID" value="Gr19_v10_g1874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1874.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35787" checksum="5965E37DDF06AD60" modified="2023-02-22" version="1">MSGNPKKVEKRLKEIFISADVLFGVFTFCCPFVLGLKVALISDRFDRLVDAHFKLKEWSLGNLEIRRAAKGNGAEIVKRVGHEVERRLQIPQEPLPDKVIGFECLEIRYIDQSVIEFLQSIRRLFDSKAIILCIGTPYTQTRCWEIIWHRIWPLINDNICAFVMHSTDLDHLRQFSPTVFGDCPKLRTIHSVYVFPEFPAVDRAGTSSGQALAKWLHTPRGDGHLPKVLKCRPWWESMGGLKLLRCFDKDNWLLVRCPIERDEAQWAEWEQAAVAWDWSCQWNRIYIRLLDRELDANEGPSEPKEITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMB8</accession>
    <name>A0A914HMB8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMB8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2110.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2110.t1"/>
        <property type="gene ID" value="Gr19_v10_g2110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037207362" evidence="2">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2110.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11222" checksum="8BA55B66BCBAE6F0" modified="2023-02-22" version="1">MVVIFAVIFIELGNAGAIQSKIKKMQESITGDTPYHQKKGKSSKHEEGSDSSSDVPHNNSSDSDSEKEEGSKKSEHKHRGKEAVKYTKLEKVKSDDAPSGCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMW8</accession>
    <name>A0A914HMW8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMW8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2636.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2636.t1"/>
        <property type="gene ID" value="Gr19_v10_g2636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2636.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26186" checksum="A13CA1DDDCFF82E2" modified="2023-02-22" version="1">MVLFFVNSPSAQQRGQKMNVPAERNGVPLACGLEAVNVHGEVIECFLEANGLGGPDFWGRSILVMQGFNLLINTYLELRFLVPMLTAVFSSPSSLQIPSRLLAMCLALYFVLLQCVVFVLLLLRLVFNSMILPLVGVHLVLVASILLQLVQMLFTGQTGTELFIWCWYLSACITFTLYQAMLFSTERSPKLCAKIAPTRTRVRRLWLLPHPPPPPRGHVLAEARELRFLVEAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNI4</accession>
    <name>A0A914HNI4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Jumonji domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 2-oxoglutarate + O2 = 4-hydroxy-L-lysyl-[protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57156"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15084"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:141495"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JMJD6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HNI4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2784.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2784.t1"/>
        <property type="gene ID" value="Gr19_v10_g2784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="106"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2784.t1"/>
        </source>
    </evidence>
    <sequence length="406" mass="47442" checksum="C2B700E783E9B433" modified="2023-02-22" version="1">MDSLPYLDHISNPDFILRHLVSNLPGILSSKFTVRWRALRQWVDRRTDGPNFEFLRARFGSDSVPILIGPEMHPTQMTFSSFIDGFFTVPSNNGKIAYLKDWHFQSAHPEEFDLYELPAFLRSDWANSEQWTTEEDSDRNPFGGDYRFVYFGTKGSWTPFHSDVLNSFSWSANVCGRKLWYLLRPGAERRVRGANDAYPKDIRECLGHFRTGELFEFVQEPGQIVFVPSGWWHQVHNLEESISINHNMINAFNLHHLVALMDRRLADVRAEILDVRELMTEDEFDRQCELLLLADCRMNRTNLLRLMELIIESRRKNAKIEDKDLLPPRDWPNFDNLSSTEISEWSQKKLTELSKKCKCEKNAAPCGQSLFCSPCAEFVRRFELVRASEVRKKLRSDRFLASNLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPE3</accession>
    <name>A0A914HPE3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPE3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2665.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2665.t1"/>
        <property type="gene ID" value="Gr19_v10_g2665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2665.t1"/>
        </source>
    </evidence>
    <sequence length="344" mass="40042" checksum="C16B279FDBAC4B49" modified="2023-02-22" version="1">MELFFFRHAEYERLYNCTGLDIDSIPLERRQFVPESIAICVLCAIYYVLYVPCMYSIWKHLRDNSCYKLLFYVGITDLGILWILGFFSGWANLRGAVFCSYPTLMYFVGMAVTALWCAESSADLILAFNRCLDLVSPRFSHILFSGPRTWLWITGCSLYAFYWALFVKPGVYSSIYFGWFFYPFVGYRTGDDQHEYEHWLHRVHNIAVAFLSPLIYLIFAAKLFYDLRKNRRQFGVVVSEMGAVQIRIFSQVFLVSLLNTFAGFLYVYIQSIEAHQWMITFAEFAWLHVHGFPPVIYLALNKTIREDCRLLYAKLFQRHRIGHIGGVTVLRPETMTANGASAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPW2</accession>
    <name>A0A914HPW2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3132.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3132.t1"/>
        <property type="gene ID" value="Gr19_v10_g3132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3132.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15010" checksum="B3A3C716CDC1A9A8" modified="2023-02-22" version="1">MPFTKSTGRTPKLDKLNAIQLIIMLLSQNKTVAKELSLSVRTIYNWKSKLGQTEPNKNPHSEQKDLMKHYYEIKDQNPKISDENIAKMLKIGRRTLARWKKQFKRQELHPNSVDGHSVEENAAANVQEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPW5</accession>
    <name>A0A914HPW5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import receptor subunit TOM22 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HPW5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3550.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3550.t1"/>
        <property type="gene ID" value="Gr19_v10_g3550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038599">
        <property type="entry name" value="LAP1C-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3550.t1"/>
        </source>
    </evidence>
    <sequence length="604" mass="67320" checksum="2ECCCC6281DA912B" modified="2023-02-22" version="1">MSMESRHRRSVREVQIGWNVSDQCDTSVSITTKHQNGPSSSPSAECGRIYSDLFDDANDGDADQNCAVGAAGDPTGTASCSSGTNCWASVKNVSLEEQQEEDDVVDEEEEEATAADGIAATRSGASMDAGSARYGVGRRSLPATLQQPHVQQLRRWSPVAQRRRHENGIDDDNWGEEAAFLDNRHVMKNQQEKQGRMVSGSGGGGGGFWQFFDSNFERIFAQSNQSSLIDARHHQCLFIVLLAFFLAFAAFVVANFCFPLSFFAVQRPMSSADRLLVFRRELQQMLNQTHFDTSALGSPRTKFTVERTLNYLADKMARRQRSQIGSNNKFSHHMPPLVLLLFSAPPAPDIASGRVDSIAAQYAVLLMKHWPEYRRINVTAHADHTKSELSNLLDDGDADGVLMLLHGIDRLRGAAPLFLHSLTDPESSPIVEAGRHNVLIILTMSTTAAQPDNVGDCETQIASSLLASWRSDTVTDDQFIAIIEFTHLKPVDMNIEMFTQPQQQAEEDLIDWDKVPDDQLKETVMERLEGLKEMFPVPVRSAFGTTAQWTWWATKHSFSFARSAAWVLSTSAFIMVLPYFVDKELQDIEKTQMKQQQQLLLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ92</accession>
    <name>A0A914HQ92_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ92"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3449.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3449.t2"/>
        <property type="gene ID" value="Gr19_v10_g3449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3449.t2"/>
        </source>
    </evidence>
    <sequence length="220" mass="23915" checksum="752AE68137FDDB2A" modified="2023-02-22" version="1">MSGPQMSGPQMLSRKCGQPSEIPSSGTTADCSECFPGSGSVVVGATCRGKANGADCNTIVSDAAANIHAGGAVTSKRFAVSATHLSTWKECVRHIRLTEENGKGTNEVLRQPIRISGHFGHQKWRDQQSDFEKEPPDLAILECKSLGHFITTIHPTTAQCGHDDCFVIVLIVNALCTIGTSQYSPFTEMYLPVCRRTEPIFPITRKLAIDRSTTIIYFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRS7</accession>
    <name>A0A914HRS7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRS7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3355.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3355.t1"/>
        <property type="gene ID" value="Gr19_v10_g3355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037571602" evidence="2">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3355.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17203" checksum="6615687659C75E98" modified="2023-02-22" version="1">MKGFWILLLAAFFTTNSLDKAKSVKLELKTFDEIFGEGWLDKGEAEDLKTPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQNPPLTESEHSGQIEPNSTDQNPPLTEFDHSENAKNGEKQNKITSNAEDERKPIGNVKLVKPNHNITITNKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTZ7</accession>
    <name>A0A914HTZ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTZ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4450.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4450.t1"/>
        <property type="gene ID" value="Gr19_v10_g4450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4450.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9149" checksum="D50D5EBBD338497C" modified="2023-02-22" version="1">MSEVQVTAESVLGLLGHPEEPDFLVRVGLPFWQGPTLAAHTSMAIRTTEFHSVDGFAGDRLLSDQEFVSLLGEFSLRSRRFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU98</accession>
    <name>A0A914HU98_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="WBParaSite" id="Gr19_v10_g3825.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3825.t1"/>
        <property type="gene ID" value="Gr19_v10_g3825"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="term" value="F:mRNA 3'-UTR binding"/>
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    </dbReference>
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        <property type="term" value="P:cell differentiation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="PUM-HD"/>
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        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="PUF"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="156"/>
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        </location>
    </feature>
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        <location>
            <begin position="192"/>
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        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="554"/>
        </location>
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            <begin position="228"/>
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        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="271"/>
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        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
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        <location>
            <begin position="381"/>
            <end position="420"/>
        </location>
    </feature>
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        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
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        <location>
            <begin position="457"/>
            <end position="492"/>
        </location>
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        <location>
            <begin position="493"/>
            <end position="528"/>
        </location>
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        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022782"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3825.t1"/>
        </source>
    </evidence>
    <sequence length="650" mass="73739" checksum="8AF1BCE53538F61D" modified="2023-02-22" version="1">MIGRLIRNFLNGQHIICKVQHVQAVHVACLHQCIKKKVCSAAVLSWGARMASSSSNRPSNRSKLSDEYSNNSGSQLLDAYHNNRADNLQLADLGKHAVAFALDYQGSRFIEQKLERASPAVKAQLMDELRGHVLKLAKQMYGSHVIRAALKSLINEISAHVTSLSLHKYGCWVIQRVLELCTEQQKRPVLEQLHDNVHTLVTDPYGNFVIQHAIEHGLPEDRERIVHILKDDIMKYAQHKFASNVIDKCLICGTADQKKALIDNVCVGGPETLQNVRQLMADEFGTFVIQKFFEYGTEDQKARLVDALRGHVLTLALQIYGCPVIQKALKSVDKTSQMEIIEELTPRACVIRCIKDRYGMHVMNTIFELIEPEQLQFVVDAIITSPSDSVASFSLHEYGCWVIQLVLKHCTEQQKRPVFEKLLENVLSLVTDQYGNFVIQHVIEHGLPEDRERIVRSLQENVLTLATDKYGCFVIEHVIKHGRAEDRERIAHSLHENLFTLVTDPHGNYVIQNMIEHGLPEDRERIVRSLKGDILKNAHHKGICSVIEKCFVFGTTKQRNALIDQVCADNGSGNPPLLQMMKHPFANDAVLKMHDLTDSAHRDKMMFAIEEHIPALIRLKARQLEHQSLTKRSALVDKRKKSNNNELLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVV7</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVV7"/>
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        <property type="gene ID" value="Gr19_v10_g5150"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="75"/>
            <end position="98"/>
        </location>
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            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
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            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5150.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27915" checksum="95F41E7A39894471" modified="2023-02-22" version="1">MRADSLSSTPRFSKEKFDEIFYSPNETNYTYAYSPSYKSDLGSRDYENPRLCRRRRFPYQSLQGMAEDRWKRELFFWKWSSCLLLLILLLLIIYTFYVRPMTRESVHMEINKKPSQRQHLPKAKQRTPQIGTVKGQPQLNLSPHRSPKGADKRQLEKTTRRLLCSCSCHTNRERLLLPDWLRSLLDAEETGRIYGGAMEAGAKSKEEMREVETGTIEASDRLCFCLYYPYSHSSSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWE1</accession>
    <name>A0A914HWE1_GLORO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
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            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWE1"/>
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        <property type="gene ID" value="Gr19_v10_g4385"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4385.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12914" checksum="8B94929DADF1E45C" modified="2023-02-22" version="1">MSGWNGMDVWTTDDVDGAHLDLWSHDTHTHRLHEQQAVQPQQMLTPNDRPSVRPIAPPPFRQDTPTKPNSNSNTTEQQQQHNRTATATQPNSNSNTTPPMKGVAATDRHNVPPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWV5</accession>
    <name>A0A914HWV5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWV5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5398.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5398.t1"/>
        <property type="gene ID" value="Gr19_v10_g5398"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="beta-trefoil_FSCN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037608972" evidence="1">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5398.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19903" checksum="0C7B61344E337FD8" modified="2023-02-22" version="1">MSSAFLFVFILTLTLLPVPSLQAASFITLHCQGNGLYVSGRWNENGQTADLPLPSEFTMFLVRGNKDGTVSFVSNSNRMLLTVLPKYFGRIVLAHQKNDSSSKFKLIPYTDGTYAIKAAANGKYASCRNFSYQLLANREKVEGPFERFYLDTVTALAEFVTARVPLKLRHIKNHRKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX21</accession>
    <name>A0A914HX21_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HX21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4575.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4575.t1"/>
        <property type="gene ID" value="Gr19_v10_g4575"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="471"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="599"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4575.t1"/>
        </source>
    </evidence>
    <sequence length="828" mass="94625" checksum="746EB77A0DB9C326" modified="2023-02-22" version="1">MTISSCLTAGRFRTTNDLDGIFKNCSGKKDEIPQSGIFVHSVPTKNGKTELRIKMSNGYNFSCHLRANKFAIQLYGIRSMFAPSKVVGCAECDKSTMMGHNFWEKPAFLVDFAGLWQLGLELMPPLSAKIGTDLKLAYFGLCPAASNWHVNITNVTSVTSSSQEVAKTLLSLIDPQKDPCQDFYAFACHQNIKRNDGIFKAKSAEEELFDIFPKPFDITMNNPPTFAFFKKRAAAGRRKPAESMTENVLERARQICTRDNTSVKEIWSKINNKFYNQFGGMPALVGQSWHHSTVKSSEAFWRIIGSLLSENIYSFFLPLKFTVHKPHVHNVIGVAPPKLFVSRHLLLKHELRHMLEEFKEKLLEVFERLQTLSGVEYLDNQHLNRSIDDVFEFTARLAQQILPDAEQNFHNTFTLNSLSNAFPSINGQLFLMGWVFWTFCRNRKGRVQQQQWTTNRTVFNFICTQILIVDMCAAIMLELMPIAIGYSYVKTIANRDDIIEDVQQQTEFLFEAFAEKLNSTSWATAETKRKVQAKLSKMKLNLGWPTQIYGDFKNTTMLDVFHKEYENFPSRQNLDWFDAFYELVKCKDRTDLNYAFKINAVHEVPSNNLVIPLAILQLPFYNISFPQSFNFGGVGFVIAHEIAHGFDNRGIQIEANANISNCTHSQDQDTCSLMDKMSLKGFKTMVKCVENLYSNKCCPIDEGELKCAFGEQTLNENIADISGSPVSYNAYKKFVQQYRNGIEEEPIEGLEQYSHYQLFWIAGAQAWCLQTPLNKKTQINMILNDVHSPKACRINQVFQNLPDFGRDFNCPIGSPMRPLEKEQCKVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXA3</accession>
    <name>A0A914HXA3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4883.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4883.t1"/>
        <property type="gene ID" value="Gr19_v10_g4883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056286">
        <property type="entry name" value="Cadherin_CELSR1-3_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055928">
        <property type="entry name" value="Fmi-1_DUF7505"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF51">
        <property type="entry name" value="PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23592">
        <property type="entry name" value="Cadherin_CELSR2_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24337">
        <property type="entry name" value="DUF7505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037341978" evidence="16">
        <location>
            <begin position="27"/>
            <end position="2887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2382"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2413"/>
            <end position="2433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2453"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2488"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2526"/>
            <end position="2547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2567"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2594"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="165"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="270"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="382"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="499"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="605"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="712"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="813"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="922"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1314"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="1397"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="1652"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1847"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="19">
        <location>
            <begin position="1988"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1340"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1878"/>
            <end position="1887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4883.t1"/>
        </source>
    </evidence>
    <sequence length="2887" mass="320050" checksum="E3D172AD92007583" modified="2023-02-22" version="1">MSTALLYLFSCLLFNILVSWPTKVSSDDNDGDKNCAFCLPSSADGRSPIASLHHRPLLANGGRCVRPGTALFKWPEECPLPQLRSRQVSLDPFSGIVFAEQRHCARRTQNDYWTVAVEVRCSDAQMWRNAKMKISLAIREQQKLRSLAKRWLRRRNPRNSRIHFKEDKYVVELPENAPVRSVIVQVQAHNEADQPLYYAFGVPEDSRSANLFSLDTVSGEVRLVKALDRETQQRHVLKVVAFERLDPSQSATVSAIVEVLDVQDNAPSFEKATYVAEIREDAPIGTTVLSVFARDFDDGANGEVSYSLKNVKDGPELAHLFSINSKSGVVQTAAQLDHESLPPLQLLQAIATDAGQPPMRSSANLEISVLDVNDNAPLFELNGTACEANVSEDAPVPSAILHPRARDADSGANGKVHYSIVTMSAPLFSIDYESGQVTLRHRATPKQSPLTLLIRAKDGGQPSLFSTLQCSVTIIDVNDHSPAFIGIGTTGGDRLELFVDENAPIGREIGRLLAVDGDSGQNGEIRYRIAAVLEENKGKVPPPPLPFELDPITGAFKTTEKLDRESRAEFIFNVLATDGGEPSRNASIEIKIRVKDINDNSPFFPQTFYQVELEEDAPRGHKLLSLRAQDADEGDSQKLTYRLVRQTPAAADLFALTNMGQEQGAVLSLAREFSPEDDKFLLEISATDEDGLSGHCNVSIKVKDVNRPPRIVPHQFLIRIDENAPIGAPVAKMEATDEDRGDNARLKFAINSAEFGIDPQNGLITVREALDREKQPVYTVDVRVEDGGNPSLSAGTLLEIVLDDVNDNVPHFLSAEYRASIPEDIPVGTSFLQVHAEDPDEGPNGQIDYLLDSDDPFVRMDRFRLDRTSGTLRVNQPLDRENVSKFVLPLIGRDRGSPRPLSTRTLVEVTVEDVNDNAPNFEFPSYDFYVPENSPAGTLVGELSADDPDLGENARIEFRIFGGTDAKFFELDRDQSEEQHNNKGTVRIRTRQQFDFEATQNKFSVELQATSGQLSTTVPVRVHILDVNDHPPQLADPFVVLVAQFVGDDGGQDEEWPELARNTTIGQVPAFDPDQNATLEFAIEKNSLIDVHPQTGILTLLYANWQRQIDSEQRICVSDGPNIACAKALFHLVPVSTELLRSSAVSVFVESVRQDELLSSGTFLRFLQAISSLWDWAVPENIRVFSLDEEHRRHANGTQLAGTVVNLFINRHSEMGEESAISSWLVEDAIEELRTNLSALFGAPLHLKRESLCVSEPCPYFQRCRSALRFLRLQDTLSTDDFIFRPISTLRTFNCECPRGFTTNASVPGECNQRLNQCFNGPCLHGGTCHPLEGGFRCACRAGRTGKNCELATFGLITCLPGFCFSGAQCQIQMPDRSPACVGCPWRPIDSDERCRLRSVSFGGDSFLAVPKAPSRMEWTFGLSFATISSAGTLFFAGSADGDFVHLYLEGGVPQIQFSLGGNDSFGGKLADIKANFVNDGDWHSVKLQYSEWKMRLSVDNCDVQSSLLLGTLSNQCAVEVAVPLAKKCLLDTAVPCHRFLDLPKSLMIGGFGPSGAKKFVGIPFVGVVKDLRLDGQLVHFSNWEQLERVGPNIWPGAEKYRPDRCLMPQEKSLCPEQTRCLDRWLGHHCRCHLRVHSPDLNCPSLQAGQEAPALTMAEDSFAVWSLPSEFSLPFSLHFEFRTRERKTQVITLDFELSAQMLIFSLENGQSIIRVNSEQYLLPYPALADGNWHSVDAHFTIEALEIVVDALYKKAVPLMALSTPRTVHSGTVPSSAHPAAFFGCIRNVEWDGQRLRLANQSATRQSCLAPNVCQMAATQCPVNSKCVRDWDRHNCKCNLGYIGDSCVDACAVPNICGPFPNTICVRLPNAPRGYECVCPDGRTGQNCENVALPAECPEGWFGQFPKCKRCLCPFENAFATQCNSTNGQCICREGTFLVSNLAGLGSEHRRCVLCRCGYGTAPGALERCDRHSGQCNCVGDATGRQCDRCEQNPASNKKLLPLLLERRSLKCVPIHGRCPSQMELDVQWPTTAEGTTARHSCSQPMMGIATRLCSENGIWSHVNDFNCTLPSLFELQNRIFESDAQNAQLFDWSRRLANVTRQNRHDLRGENVQIVAKLLNELVRLEMAKNGTNSAGEANGGGVESARGNHFALNLLHVADILLAVLRGEELSHHKLAINLANYGAFLTDLYERFRFLRPFKFGGKNLVFVIDKLAAKVSPVVVTLPPIGDSLFRHRHQISHANAAVRLQLEFAHHPPTNVSSVRIFYSAFISGSKKDFSTVLSLYASKEIVTILNTLNIALPIADPFGHYECMAKYAEGHWQNVHLVGLNGTHAQCQIARGDGQGKWPLFIKAIANQKSAGVKFFPFAGCNRVHYSTVFSPIPIICTLCAMFAFALLALAFAIALCRQNRRYRMLRCTVIAAFSLNALCVQLSRRVLPADNDGLFCAALNSILAASICALFAWLLLYSLFLCKLILQSADKNCSQTWNVTFGVILPFLVSVAVFIMPTKVEECRHVPIGSAPFWLLTVPPAILCLLNFYSLATSWMLSWHKQYQLIVLRFSFRRVHFSHSVLVFLCAILSIMDLLQLFRPFPSQIFAILNAVLLAFIAIHFVLWANFFIATPKEDNNAHSSTNSDKSAESIWMAREAEAVHQAPVPVQSQLMCPDSSARANFYVNSPFHRGISPFTHTAKRRPRLSDGKVYEGIPNEWIPPGGEGGGSLTEEPTYLHHTLQRSLEVGLPQILSPPQHPAPPSSMVDGNWPLEVREQQPRQHFLSGTLPIGGASNFVHYSPLQKQFGLKQRRHHYGSVHAIDRNEMTPNTRRRTQPIQFPAAHNGSLKNVTTESTRNRKFGLENVLDDELNCAYFTFTRRRDQLVVDQSASLAATTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXS4</accession>
    <name>A0A914HXS4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">cAMP-dependent protein kinase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXS4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5457.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5457.t2"/>
        <property type="gene ID" value="Gr19_v10_g5457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14209">
        <property type="entry name" value="STKc_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044109">
        <property type="entry name" value="STKc_PKA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="536"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5457.t2"/>
        </source>
    </evidence>
    <sequence length="887" mass="99912" checksum="4255CEE81BB0FC41" modified="2023-02-22" version="1">MVSSTFLVAVPSPLDQQQDKLSFGLRQQQSSHQQHNNISRSMFALSQLQQRKQFGRLGCGCLDVENCGSPSSRCLKQLNSGELPPLESPSHQPLAHAPSHWFHRQHVVPNHQFVMNNGVNNTNDFSSCSMPRHFDNANDLQLNQQHHLLPQLYRCPPVPFFDVQNKNNNSNEQRDRLCMPLDNHHPFLSSDGPFPLRRVFSANATASSTPTTAEDGVKGGRNEDGCWSCTPPSPCSPCSTPATPLSPPVQLKQKEVTQQLETLSNIQQLNTNQLGTLSNIQQLNTKGQPNQLETLLNIQQLNTKGQPNQLGTLSNIQQLNTKGQPNSKPSSLHFGLPVLPCGSASKFGGLTAGTPVRRHPQAEAEFETIRENVLDKMDHRPFVADDNNNFSQLETTSTSTVRHDEQLGLKAEKCEQQQKKFSSLPPFGGIVCPLSTNAKHSSSSFNVDYDKFPSFRPELRHAQSWPFPKGTVTLAIERKSFVQKVCDLFKQATTAALPGGAREFNLRAELFWLKSAIRHTMRCLLKWQNTSSLDDFDRIKTLGTGSFGRILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMQYSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSNGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFASVDWIAIYQRKITPPNFNVSFNAKLPADVPRVFEALYPKVSGPDDTRHFVEQIDEADELLLPQAADDSHGDVEAPFLPKCRGPGDSSNFDDYEEEPLRISGTEKCAKEFAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYH4</accession>
    <name>A0A914HYH4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HYH4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5830.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5830.t1"/>
        <property type="gene ID" value="Gr19_v10_g5830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="78"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="80"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5830.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24319" checksum="161E9275D93D2229" modified="2023-02-22" version="1">MNCKLNMLNPADGPPALNPMIFPPAQQETAFEQLANLQYSFASLLSSYQSQLHLDDPLVAAAAGMPHDSVQATVKNFSSCRRSRTTFNNDQITELETVFRKTQYPDVCLREQLAMHTGLSEARIQVWFQNRRAKARKSMKRCSALPPTTSLPSLSANPNFLCPPEMNTDVFRRCSISSSCSSTSNTESSPQLSPLPTPQKPSKSPNSFFIENLLEDQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ98</accession>
    <name>A0A914HZ98_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM39 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ98"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5163.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5163.t2"/>
        <property type="gene ID" value="Gr19_v10_g5163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019397">
        <property type="entry name" value="Uncharacterised_TMEM39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995:SF4">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10271">
        <property type="entry name" value="Tmp39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5163.t2"/>
        </source>
    </evidence>
    <sequence length="533" mass="60903" checksum="9CE5AFFA1560469D" modified="2023-02-22" version="1">MARFTTEPKTMWWLPKSHWPSSLKYHLINPYILSCIGLLLGVRVTKCFWDTITERIDFFALGQDGWKLTCWKVFTRIYVEFGVKSFFCFASPFLIHLALFQRNVVKTILSLRFLQPIVVFLPFNLSTELVNGQFDVSQGLINLATFAHLCNVTAAQIRDEATFFIINGLLCHFHAKNIFAAKNYHCVVALTSFSLYFTYLFPINYFDLLYRCVVHLGQWELIQPATQQPNNIPLQQQRFGVRIQQNEQHNENYESFNETSSLPYQDGTRLLFRGNLYIARSHPHYRTVCAEPGNKWHLQLYKIAKNPVALVSYMCIFQCALVAFEFWLLLLTNDWQQIVTLVLLMRKDPESGTIVLAQFYSLDVAEVGNNVSTYEDRNRIQRVILIPGSSVQSVQLLEEEGNEQVVGTVTGDGRICGAVKNTAKLREKIERMFWTYGETADGSNGKRTLSETLRIFDDEKPHVLTRTAGEESVVKGSTTLIVVKGGMTIYPPYGKNDIFGGAIATKELYQRLIDTFNGFAAHSPPILHNVAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZP4</accession>
    <name>A0A914HZP4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZP4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g552.t1">
        <property type="protein sequence ID" value="Gr19_v10_g552.t1"/>
        <property type="gene ID" value="Gr19_v10_g552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054091">
        <property type="entry name" value="Cep192-like_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054090">
        <property type="entry name" value="Cep192_Spd-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22073">
        <property type="entry name" value="Cep192_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22074">
        <property type="entry name" value="Cep192_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep192/Spd-2-like" evidence="2">
        <location>
            <begin position="178"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="3">
        <location>
            <begin position="307"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g552.t1"/>
        </source>
    </evidence>
    <sequence length="564" mass="62921" checksum="5E6EB05944790BCD" modified="2023-02-22" version="1">MSEGDFLNYSSCSSAAAQLLFSIPSQQPDPPKHSTPKKGGEDVGRPVFDESAIYQIDFDRKSSTSSAVSHRINNAPILSEREQVNNFLENELQKRRTTAALNAGIKEQSLDSLNKRIVRDDLPCSSSRDSATTADLMAAYRKMPKFEIPRNSRPLSSASDTDMASSSRPSKLAFERGKDKLNFYCVPIGEALVLRLRVWNVDSMQMRLKCGISDEKGREHPNFTIFEVTAPIMEPGGQCEIAVQYKPTKVERNFAHLVVERTNCEYFKKTFQLIGDGGCADVGLAASNYTDGVAKKATSSQAVVIQPNDPNHFWLEFENRGQRPAYVKLVTTNRIGKSIPNEQICINPEQFVLNSDTQNRWKVSVRVSETFDWCGEISPPRFDSIGRQHSKEVVVFGKRPPRESVGTGGGRDSILSSSSSGTASSQQQQPDCAFRIEAHWGEEQQRQRLKCWQWKSKLPALVNGLQFTSTFEGEHPTTIAQRQKISATLTDGEAAEFKNSLRQLTFNVVNVQAKAYFPPWQPDVKHPIIELYRNQSRLLKETIPDEESCGNAATLGLLLTSCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I110</accession>
    <name>A0A914I110_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I110"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5619.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5619.t1"/>
        <property type="gene ID" value="Gr19_v10_g5619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037180305" evidence="2">
        <location>
            <begin position="35"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5619.t1"/>
        </source>
    </evidence>
    <sequence length="625" mass="67860" checksum="CC524FF764BCD945" modified="2023-02-22" version="1">MCQPNQYRHHPIVVILLLLPLTLFLAFLPSPSRACAPPLPPPFLANNFPNPNPNIASRHSVNSRAFGEQIHLPEDAAAPTEAPQNGVGGGIEQRASTASGPVREPKELFCYDFDDKCRWRNMEGFLVDDLDWYQGTGFLDENRLRLATGTHVSPDGFYGIAATDKVELSNAKGILVSDVVQCQTGTAELRFMYWTSPEVKITVCVKSILRLFPYFDYCSKPVENNDPGPAYVTLPDLGGESLQIFIQAHNFVFNSAALQGGFAIIDNLEYYGEFCDSADGYQQQRFAQSNAAPSETVSRPGPMPKSPASESKAGNIGLGGPELVYNNVVGNAQSGGFSSLLDWMLYGGGRGLGDNGTTTATNKLLSNILPNNSPLQNAMTPNSSPFEPNLNALFPTLVSSQTIGTAGDVVTPPTLKIASGVQQPSSASSSAFRALLTSSPAVQQSKSLTEAESARPYPDIENPLNSQIWPNPMASQSEPAASVEPLQALRSLRIVQQNKGEQLQQMSAENGPADEDDDQSKAFAGRPFPGGDNAALQKGLSQHQHQQQFTSVPSRPLNSRRPLPHLALLNKRKMGERTEVAERDEEEEEEEGGRGRMMNGDEDGRGEEGVTEEPNFVEREEWIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1B5</accession>
    <name>A0A914I1B5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1B5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6376.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6376.t1"/>
        <property type="gene ID" value="Gr19_v10_g6376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6376.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11813" checksum="D29B5FC02101F2A8" modified="2023-02-22" version="1">MIERFIRNFLNGKHNIRKLQQIQTVHVSSSNRPSHRFKLSNEYSNNGGFKLLDDYHHNRSANFQLADLGKHVVSYALGPHGSRSIRQKLGRVSHTEKAQFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1L8</accession>
    <name>A0A914I1L8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1L8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5765.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5765.t1"/>
        <property type="gene ID" value="Gr19_v10_g5765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5765.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="31428" checksum="27830F419D14C0EC" modified="2023-02-22" version="1">MIKNAEDSKLAEEAFKVIDLLRTYIKNNYQDVNDIFRALNISKPIIVKMKRKDSANPSGMTEINQNVNIDSIKNINRYGMENYDMRLEKIDKLIVVISKKISRILWSDFTILKQEELEKIAKLKIMDIMKWKENVYKAMSKKTERYELGMQAQNIELQKLKLNNLFINFQNLPNLFIPPKFTKLNKKLEKKHAEIDSTYNKEYALINSPNNRPSYVYNNKWQHWHNLFYTKHFFMAIDDMETFNLSDEQTIRLNKFYYGTVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1P8</accession>
    <name>A0A914I1P8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1P8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6682.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6682.t1"/>
        <property type="gene ID" value="Gr19_v10_g6682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6682.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32304" checksum="F488B33D05F9A77E" modified="2023-02-22" version="1">MPPLWPDLIFRLLPGVGLLSTCAALTFLVALRRVQMDSFLAVIYVQRLLDLLLGLSLFYAGFHGIHLSVQYGSEQDAHQMPPIQCLFTALHLHIWVYTDSAQLLLLTLLCVDQFISVAWTKRHKEFSEYYFHPGVLALLLVCASGAFVPAWHAPIRLVDNGTVQISSFCEMPETFGQHFYGIYLLVRELAPVPAIVALSATAFAVLTLQLIQRGRFKWSDNNCQSAKRLLLILCRSLLLLAAVHLPLATLRRPRLSHELLEFREHGQEVALRAFHAALFAMVGQICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4A6</accession>
    <name>A0A914I4A6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4A6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7378.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7378.t1"/>
        <property type="gene ID" value="Gr19_v10_g7378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053322">
        <property type="entry name" value="PLA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228:SF5">
        <property type="entry name" value="PHOSPHOLIPASE A(2)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228">
        <property type="entry name" value="PROTEIN CBG09474-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036904165" evidence="5">
        <location>
            <begin position="20"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7378.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="50224" checksum="150712D6D7A7093D" modified="2023-02-22" version="1">MKKCATILFITTYVMHSMAKTTPKAPRNELVAYEDWNCGATSFDKPLSHQMAQGDCPKRMFEADLCCRVHDMCYMEEHRSRDNCDEAFCYCLERTVAQPARDANQTASGCVSVSTNFCEIIKMFGGIAYSSSRDMMTQQKKAKEALEAEESRKAMLRSTTVKTMPESTTSSSSTSMASSTTPTPLLKSSTSPSTPSSVHSTASPAEIGQFVTHKLPLECFDNALSTCTRQLHQCVSEQFGMRNEANERLDPPGEDVLLLGVQFAECSAQFCACSVAESARARQASVPRRLLGGEQCARSLGHICSQFRDVPNKQSTGPANVHFWSVSVNYTGFSASLGLVATSTLFLSLLVLVLLGRFCSKALVRSVHKRLYGHSIRKHYDGGDPLYLAVGKESTASSPTGDGQQQFPSFSSTRTSRAELNMPLVLNSSNSSQVRLLSGSGNSSSTLFDACKRPLSFLHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4A7</accession>
    <name>A0A914I4A7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4A7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7177.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7177.t1"/>
        <property type="gene ID" value="Gr19_v10_g7177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7177.t1"/>
        </source>
    </evidence>
    <sequence length="459" mass="49716" checksum="DA4138AD96CB0F2B" modified="2023-02-22" version="1">MFDYDRELNIAQQLAEKTDDNAIVHGLEGLLRRCSSPNNGFHQLGQFRQKSASVGSDHLYSTQFLSKRPPHHLFDGLKNSFASNGTSLDMQNTFRRLSGGSAGTLADAYECDTSSGYGSLLGTPLASPAMSSAQFHAAQLQKMFMDPGISEEEEIALDKQDMASFSHAHHFVEPDLSPPPQTLSAVQRRRMATMPAIGIAKAPAPPPHPTLLMTNTTTAHNNGSTATLLKATTTTTGTNKNSNKRKTSLNTTVGQNNSNNTNNGGGAGITTGPPSAEQIVPTEDGFDFREIKEFTQLLHSPRRVPPPRYICHICYQPGHYISDCPARFNSPYEELTPYQGRKKCYGEFQCEQCKRKWTSQNSVANEAQSCIKCHVPVFPHKQLPVDKAVALGLVKLQRLPVTNIGSSSSTENLFEQGSVGLFLDESSGNSFIGTSDSSSSSPSLTPPMMAATATASLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5L2</accession>
    <name>A0A914I5L2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5L2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g753.t1">
        <property type="protein sequence ID" value="Gr19_v10_g753.t1"/>
        <property type="gene ID" value="Gr19_v10_g753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053326">
        <property type="entry name" value="GPCR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="100"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g753.t1"/>
        </source>
    </evidence>
    <sequence length="543" mass="61376" checksum="3F3984B2A5450508" modified="2023-02-22" version="1">MDNLSNLDYAEEYGEANIELQPTMLPFECNLTAADNAEQKTIENVHLLFRYGIINWPNFTNCLPNCGLCTQFASDQFYITYNLVVIGLLLPFISLCGLCGNVLSAFVYSRVSLRQSYSGSLYLSALGCSDAAVIITALFLFFVDSIRRYSLALSVVYGSLSPIVYPAAMIAQTCSVYFTLVAGIDCFVQVWLPRAAKDLFARQCFQKATICAVLLFAFLYNVPHCFESILLNCWHPTFQSASVELCPAPLRYNPTYTLIYYKYMYAFFLAVGPLVILIALNTAVIVGTMICKRGNSEDNMALILVVLLFILCNIIALLINIFESHLSSALSWRINYIIDISNLLVVFNSSLNFAIYYNFSRPFRATFLCHFGHKKMPPLTLTVAAPPAPPAQQPNCPRARGGGAVDQTEVNGMHKVMLVTAREHRSPLIGLEKCTSGKLWGSTNGNVHQKRNADRKAYESCPLGRVDEAAEEDGGHWKMRRKMKHDVLCDEDHHRKMKHDVLCDEDHHRKMKHDVLCDEDHHRKMKHDVLCDEDYHRKMKHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6B9</accession>
    <name>A0A914I6B9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6B9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7909.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7909.t1"/>
        <property type="gene ID" value="Gr19_v10_g7909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7909.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10251" checksum="C9DDF1E857088CFF" modified="2023-02-22" version="1">MELFDWGGMKMFLNVPATSVSSERTFSMAWLLYANTLRNRLGAKMAENLMLIKASLKKTMLAPSVELDDDELDDKKLKKMYLGNSKLIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6I0</accession>
    <name>A0A914I6I0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6I0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7957.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7957.t1"/>
        <property type="gene ID" value="Gr19_v10_g7957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7957.t1"/>
        </source>
    </evidence>
    <sequence length="408" mass="43925" checksum="F3F3B908C5B0FB61" modified="2023-02-22" version="1">MEILSIPPPPQQSVLCDYRLLKSGPFTPPPPRALPSQIRRVLLHCKVNGRKRAAAAAAVASSSSCSSSSSTVDESAGRRTSNDEDDNSRRLRPFLGKNPGGDKRSDQQLISITNVRAPTCQTGRRGRCNSFANGNTCSTIATTTRRTITMWQFCRHDICRATNKYDTLGLAELGPSLRTTACQPRSPSRTSLATCSTFRMTTSGSVPSSCRRSTNTVNTSWCPRWNGMAQTQCLFDKPTERRYYEKMFETPAPGAFYTVSQQCKFVFGAAAEISVHSVLSSIVVLRKLGVEHSTCLGPTRRLAGTTCGAIGDNVSACRQCSSNSLTEDGAIGGHGESVRAHAEKVSKRHSGIATRHDPRMAANIVLGSGSAIGHAMFRTAPGTCPVFVIFNAPNLTAPTLAFTGCLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I714</accession>
    <name>A0A914I714_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I714"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g750.t1">
        <property type="protein sequence ID" value="Gr19_v10_g750.t1"/>
        <property type="gene ID" value="Gr19_v10_g750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g750.t1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42459" checksum="B4861946812DE507" modified="2023-02-22" version="1">MSDNPKKVEKRLKEIFVCDDVLFGVFKFCGPFVLGLKFALISDRFDRLVDAHFKLNEWSLDVLEIRRAKGRKSAAIVKCNRWSQVLHSMPIPTEEPLPDKVFGFECLKISYIDQSVIEFLQSIRRVFDSKGVNLCFKLNYGNRSWGITWHRIWPLFKANICGISLALSNLDRLRRFSPTVLDDCAKLRFIHSVDCFSLFPADDSVAKWLHIPCGDGLPKVLGCNALNTERMEGLKLAFVSSVTSVSFIIGFNNPPYRYCWLAPFELRNNLTGERLVLRRFVEDFWLLVRCPIERDEEKWAEWEKEAAMWGCGPPEWRTYMSGWEKEEIAWGAWRPWNQIQIDFKSSDIGEWAADKDEGPRVSPKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7B4</accession>
    <name>A0A914I7B4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7B4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8171.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8171.t1"/>
        <property type="gene ID" value="Gr19_v10_g8171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8171.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27687" checksum="39280638EA3C4673" modified="2023-02-22" version="1">MAVGKNKKMGKKGAKKKAVDPFTRKEWYDIKAPAMFTHRNVGKTLVNRTQGTRISSDFLKGRVYEVSLGDLNSTDADFRKFRLICEEVQGKICLTNFHGMSFTRDKLCSIVKKWHTLIEANVAVKTTDGFMLRLFCIGFTKRNANQIKKTSYAKASQVRMIRAKMVEIMQKEVSSGDLKEVVNKLIPDSIGKDIEKACSFYYPLQDVYIRKMHGEGAGTVATITTAAGEKIESRPDAYEPPVQQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7D4</accession>
    <name>A0A914I7D4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7D4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8186.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8186.t1"/>
        <property type="gene ID" value="Gr19_v10_g8186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8186.t1"/>
        </source>
    </evidence>
    <sequence length="410" mass="48359" checksum="69749313CC87E8EF" modified="2023-02-22" version="1">MTQFWFCFRLVLATIAHFNWFAAIYVNCIFFTLWKSYDILWFWTHLSLCVCFPALRPENNLIVFVKLVRAKCNGHSDKSYKEIYELLYSDMPDETKAERELRRIETLRREKRDTKRRGQRPEDPKKRQKLMLKEDDDASSDSDDEDSSAIVQSKGVYPILDQREEQPMPNIRVDRAKGRAKNRKGAEFGEKEDLMEGGNNAVDGKSRGMRKWMPKFLISHQSAELEQSKREEKLRDLEKARAKKEESAQKLLEKKAMRERKRRKMAELRERARVERRRKNFAGAVDLLLTYCRLITSFAVLVGNIHKTFIPRYLAPPLENVYDSPDLLMIFTITLLIEVGFFWLLVFWSYCQQMALCCRLGFCRFLLWCTALVLFGGGLMLYPMHFIHEQLDETWCVFAEGEPLSEYFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I826</accession>
    <name>A0A914I826_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I826"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8346.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8346.t1"/>
        <property type="gene ID" value="Gr19_v10_g8346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8346.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="11801" checksum="A2A263070CFBF412" modified="2023-02-22" version="1">MGSFSSRISWMASQLGDLGGGSGRGGGSGGAVRDAGGALGKMEVAREKNTSTNLSTTTEAAAQTRARSSRRAGQIPSRRGGTPQEAHPTVGGGIERDVSGRRQLFANSDTNTFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8B6</accession>
    <name>A0A914I8B6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1 atypical kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8B6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7840.t3">
        <property type="protein sequence ID" value="Gr19_v10_g7840.t3"/>
        <property type="gene ID" value="Gr19_v10_g7840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7840.t3"/>
        </source>
    </evidence>
    <sequence length="285" mass="31191" checksum="01C556D851A32679" modified="2023-02-22" version="1">MLRLLIDSQLGYELRHLRDPIRERIVQAAVLGGNVVSVDENQNYSVTNKKAPTSFAGADVLDRARVVAVGVETFMELASRGVFPGFGGYELASQGLINKVPEQQQQQYSTVVPLVKQQNIPFQNDGLTREEEAFLRRAAMEVGVVCTDNEQKVVGLPKTISDGNSISSEPTIPKDYRPSFTTNPRTNSAMMDSSREFIVPASRVARLFNFGRLAASRVYNRPFILSTVATLIGGPVDEDNCTPSKGKFSAHKSSPQYIECGKNRSNALSSSRSSTEIGTNALNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8S6</accession>
    <name>A0A914I8S6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8S6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8336.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8336.t1"/>
        <property type="gene ID" value="Gr19_v10_g8336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8336.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26608" checksum="E5274648D17406CE" modified="2023-02-22" version="1">MQHIKIEFDTTETRKNPSSDHEEYDGSSSSTSNESKVQNGDCGHHSPTPSVKQKSSPAELSDNAIAQTKTFRRRTAFETSEAMREIFGASPFSSQQKENLGEINRKTTTENQQNNKREIRLSELEDDVENRDFDHLSEVEGMSVPDGVAQIMNERPILENGVTKMNNRRRSDNRILPAISGSWERASRPAVVNWHKSAGPSSVGWRSAANPPGAAVCWYCGVKGHVAVHCRKMRRKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I982</accession>
    <name>A0A914I982_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I982"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8673.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8673.t1"/>
        <property type="gene ID" value="Gr19_v10_g8673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF174">
        <property type="entry name" value="TYRAMINE_OCTOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="111"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="451"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8673.t1"/>
        </source>
    </evidence>
    <sequence length="664" mass="73822" checksum="5A97F0C4BACB296B" modified="2023-02-22" version="1">MMTHFDGPTHSTGGGSTFFFGSTTKASPSTIKMIIGHRSHQQHSAENNMAFFSPYIRDKNYEDDGSNKFAFGTQEICTFEQWTQLPNQPGPFRIFMMIAILAMLVILVVGGNALVIAAVMLRRRLRSATGLLILSLAVADLLVGLVILPFSLANEVLNGFWVFGDTWCTAWLTIDIWMSTSSVYNLVAISVDRYIAIIKPLKYPMIITKFRARLIVAAVWLSSFIVCSPSFLLASSKRKSYIEEQMERNGTISAQQFVLQNPNACRCTPSNSGMYYILFSASSSFYIPYVIVIFVYVRIYNAAMNATRSAYAGMVQVAETAKKKQDGKKVPNGANDKSATTTKLKLPKLFVTRSAQLRKKHHLEMHRFSMDPPRSIPITINCNSSPIVYAQINGSCGNLGIGNNRFSDFERRRSEDQCLLEDRSGASPNGRSEPSEMVYASHDRLAPLAPRDAVGDTSEESNGSGDESKSMLTPNKTVGGTETNKLEGHIANGNANSGEVPPNSKEPQGAMSAIKRRRNFAARLMSRILGKAKRRRAAGTYEKRLSLEIKAAKTVAIVTGCFICCWLGFSIYYGLTAFDVYVNEVVWSIFFWLGYLNSAFNPVIYTVFNREFRTCFKQLLTCNNMIFAGRNANQAPMCNSFNSQLRIGNDAMVRRQQGEQSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9U3</accession>
    <name>A0A914I9U3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8223.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8223.t1"/>
        <property type="gene ID" value="Gr19_v10_g8223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="652"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="684"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="719"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="366"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="584"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="815"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="866"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8223.t1"/>
        </source>
    </evidence>
    <sequence length="1309" mass="142927" checksum="B3CEBCAAD0EADAE6" modified="2023-02-22" version="1">MLRFSFRCKDNFWFFLICCELMNEVFICSLIMRSIAKVRCALRGVVNSHLDQKRQSLLPFYTSICRYLLPAAALPKFQPKFDAMHPPRVASNPTSAAAVSSRKRPTAPSIMSSLSGQSALSASSNYSYSSSTSSSSGSVAPVKQLGIFRLHENNISQQRETPQLVDITGTVDVQQQAVIQQQQLLGNLLSALVVPQQHQQQQQYTTSPQMMIALIEATKGLSGGASPFVGTLPGIPPPHPPPYNQSATPPMLQKTLVDKCSTASTNCIRDGQMPRGPMSNNNHNNTTTNANQHILRPPPPPATTAFGNNVSGHNSAGQLLASFGLPVYGPYELLPRLLSALQQSPPAAIPTQGQFGCHFAPQLHLNNANGTKQSPQLNQQLCQHQSQKSNDIPPTSAGINRQINSNITDGSSNFGNTGAIGKGSSPLEKSSKSSKRRSSCQNQGSACTPLGNSPPQQSPSNNVNSSVKTLRGEVQRTDESVRGREERNAEGKKKWGGNGTEARDARVATSGAQRPVPRKTRRLSVDCSADVPSSSTGRAGALSSSPKDESLDMAPSASSASSSLARTKAFSQQSLNDIMPAAIDSQNVSPSSSQSSDSPTGTNASPMEQDGEMSTADSFQCLWQQCGEVFIKEKPFVDHVNEHVRGEQSPSFFCRWDTCKRREPFNAQYMLAQHVRKHSGEKPYQCEFLFPDGTRCKKSYSRLENKKTHERTHNGERPYQCAVCNRSFTNASDKAKHQNRTHKKTKDYHCPVMGCIKQYTDPSSLRKHVFHEHGEEVWHFAKQSKEEKGSKTYGVNLIGIREDGTPYLIPQAQMPLSSSDEDREVDVMSTTPPPGSHSSRVLRASSHGEDRRGEQQQQRMTGQWLELNSSSQNGRAVTGPAGQQQSLMMRQPKQENVASPMQNAGNNAIAEQTMLSSSTTRLQQLKMDRGAADYQTQQVQYVSGTDQTGQQQQQQMFAFAQRQPANVARPMPQQQQQQHRSVVQSIGSHKHDFPPPIHAPASVVHVGPPHHRPQFFGPSHHNSPNPVLNNGTSPPAIFDFQTQQFRELDLMNSPEDPMPSNESGGYDGGNEVGAYGRMPVNYHSHHLRLPGGHVAYANSEGCVAAAVHDVAVHNHQHYGYQQHCQCKEYLVECQPSPPTGRCMAPPYPPPPPPAAGVNQSNVLHYSMCAYGNNKCDMTTSGCCQQTEAVQQQQRLYDSSLSLPQQQHYDGSDHGQQMLIHQQQQQAQQYHQHHQTQALHPGGTITGPENAGSLQQLLHAHPNQNPAQRVVAPPSAPLSVGLLEDIELDEVSSTLSDLKMSGGGDGGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA40</accession>
    <name>A0A914IA40_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA40"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8904.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8904.t1"/>
        <property type="gene ID" value="Gr19_v10_g8904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8904.t1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50330" checksum="CCACAF873EB99212" modified="2023-02-22" version="1">MENEEPQLHIDVLLNVAEKLIFSPDNDFRLDLRDPNADIVNFMFAGPACRWSFLSQFRKLTQISVNSAELQLYAPKPIQGIRGTLSNNKEFFQGPFVITDQFFYVLFCQGILRPTVVDTFFIFGNDITTLDSVPSSSVSMMVNDWKEQSENEEEGSENGEPFYGDSQWNEEEASGNPKRDDVSFTVGESSAESLVRLFLFRDSPDCLDNLSSMDLAECQLCMDFVKIHDDTTIYRHINRILNLNAKDVLLEISAELRDIVTTVVEYHFPVVASRTSKLVFTYTIDVINPERESGLQFPADEFVSLLCYMAGSCPNLDTFLVSFLLQGEFSDEDFKLLSSWLYQSIQSVLSLHCSILRIGCTLTIEFRAFFPEATLMEASKTGHCLATMGEQRRMDDSDATEMDDMPDTYTISRMVQMRDEPPIRVLYSLIGLEEDSVNDGWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAB7</accession>
    <name>A0A914IAB7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8961.t3">
        <property type="protein sequence ID" value="Gr19_v10_g8961.t3"/>
        <property type="gene ID" value="Gr19_v10_g8961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037754847" description="polynucleotide adenylyltransferase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="11">
        <location>
            <begin position="900"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8961.t3"/>
        </source>
    </evidence>
    <sequence length="1423" mass="165722" checksum="650BF0C809543A7C" modified="2023-02-22" version="1">MLKQSVFIFSSILFTLSVLLLLLLITVVAKQNDNNNVSIECPKQNVPIELLRALDMKKLPKKRFEILDEMRNEFTEILSTNFAAVPNNFVQSDVKKKLSIKVVIWHFKLIVEDSLDRIEQMEVNGNYWTANEAIKMGEEWANLLQNVNGKSMEQKICLLQAFTHRIIRNEISKTSDEWKIFVKNVARAIFSINVGSKFGYDTITTLSEEEYMEHAKKCDESEYSSNVTNKLLSLDSSYLIHRLCLHILIADSEEFQHFLCYHKNIAIYKQLFHLIMGTTELYVLEEIFPNILHIEKLSATRRLDGHFVQFHYRTGSECAIGQESRVTIRLLLGEPELIECEKAIRQKADRGTQFGRHMLDKLNAVKKAALAKAAVMSPKGICMVIKLRDFLGKHNTGVDLREEELKSVDEWWPHECDQPQEVEAVFRLQRLIANQKNRERQSYICFMALWRKLVTFPGRPTRLHKFLQLSEREIELECIYDYRYTDPKVFRSSEQLEILYTDALRTANTAHQKATKLAADIFCWVFWLEANVLELNEEQKNGKMPRFTMAWRQNRWYYEMVYDQLFDIEKADEEAELDKKRIEIDILLDKSTIFVHESLKMSDGKLKIELGTQKIKRLAQQNGTAPPPPGTLDREWYEIRRKSKAKQESVVREFEGLLQNIHFEIIKNLLSKCNKFNKEFGQRSLDALRVAAFVGEKNWDEKEIINGQSENTEKPGPNIEEQTPFDVDAALDFYVVNGSSEQTKSDETTGSEVVANEIGWTLFLRDEFLVQTYQKFFTNPTESMRQIVTIGCYINEIGHRMEVIDKFTYFNHFSLMVKQIEQDQKLRNELSNYLQNNVFTFAEIFGISLHLQEIRPFDEENFELIGDNSKSLDSLSAFLSKNGFGLISNDRKMKIDQSIKQIEQSAREWNYKAKILVTGSYVLGTLTKDSDIDVICIIPELLPAWGPQQFFGTAKCEFRRNGQRHCADKSLYCRLCLVLKVVKLNRIQDAWMPLIELKFEIDHNIFIDFDIGFAAFAPNEDIFQSNESINFQQSEALSRSLRTKFEELAYRRKEFFADAGGESYEKMMEMNLEEEKLKMKLRSLSGFEVGVKILNKLFATEHSQNDDNKIGILKTYRTLLLAVKMWAKNHHIYDNKLGFFNGISLSILAAKVMLLYPMASIPFLIEKFFFTFSTWPWPTPVKLTDLPDGSVLRWEPRDEGNKRHEIYGRLGLFADLTMPIVTPGLIEQNAIFNVNKSTATIIQREIQEAIKNIRNWPNLTISQDERWEHLLKDKNFDEKYSHFIRITCEATLLMDFDDFCGYVETRVRLQLLMDVERFDHIRLGHSKNVVEKGQFFEQSKGNKKEFFRKIWLVGLELADKIVLDDGSEVEKPVNSVEWIQRLNSMLSDQFGASIEKAYRMKKHLVGIGTLRPHIQLTCKYESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAP9</accession>
    <name>A0A914IAP9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g8442.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8442.t1"/>
        <property type="gene ID" value="Gr19_v10_g8442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF38">
        <property type="entry name" value="PROTEIN QUI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="5">
        <location>
            <begin position="690"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1148"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1381"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1516"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1559"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1728"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1750"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1789"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1838"/>
            <end position="1849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8442.t1"/>
        </source>
    </evidence>
    <sequence length="1849" mass="200543" checksum="E535F0A3DA7E1090" modified="2023-02-22" version="1">MFRSDKQRQSKKDKLQKDPPSGGSAGGGAFVVKRPAHLRSAVAHRNASLNSSPSVERLSSPTKGAAGGGGSLNAARLRASGSSTTGATSPEACTAGGAASGDNDVPRSHMLAIVLPSLEEFVHEREVLRNVLVDLQQHFAELDLDLECCTLFEMEDVLQNVDECVLLGELLAQRNATALVFIGDRYGEALLPLELRPEEFDALREAALEAADDVAVLLNQFYVLDRGGGETGRAAEYQLKASRDPAGAQRLRRGLQRCARRLFDGDGALALQPDAAQRHAQLFKSFIEWCAHAAEANGQSVLVTRRFHGVQNNAAGGMERWMDAAGSERAEHLNALKNALSTRLLNDPQQRLLPFLLDLRLQQKIEIDPSSWWTKCPKESAAYELELATKLTDRLKSLILAAHPNIEQPRHPPLHEPRTAAMAIVQAEHCVHSAHLASRIATRWVPRGDAIDSHLDGIVKRLFDKDENQLKSAGLFVQFHGQPGSGKTGALCRLYQLVHDRLANAAGDGKSPPVVALARFSHLTDGTIFANEMLRNAFLIVCKQYMPTTPNANAEKMIDAFLGTFHLTEVLAQAKALLEQAHALQVLLLLDDVHLLRFGRALGRMDNALRKLFPRLHIVCTSASAQPMLGFPRSVELLALSAPTADQAIGILSDPLRPLPPDQLSALRAQFHHGSDGIDLVLGAVQRDELLAGHTEVSVSIDARLARAEQRCGGADAVRLVCEFLCCAPCGLTRAELLDAVRLRNFTAGFMFEPQDVLNAAPLHVLRNLAPLLDSVLVDARRVLFFRHHSIAQAAKQRYLTSPGEIKLANETIAALFRDADSDADAAEDAASGASSAEERAAVAAAVLLFPRPISKEGGAGVDIRRVRFHWYYLLYTGNVEALKKETLCFFPYLEAAFRACGLARLLSIFEECLQQILDHDLLVIFEQVLLPGIQTLIRDPRQFVSEFLNRLRYTRAKNSVYLNILVEQAMTWTDNYADSSLLVPLTCWIPPPKMKQVLSFTLSQWKSCKLTILQPTHNHQHLLVAGNELAPDCIYMFHIASQLLVRTFASSDQKQVTSLCASKWRDTGESVQQQQQHNHHFFVSTSADGAVRVWSFTQAQCLKTLRACNARILCSVLSNDDQWMAVGSADSCARVLLLDSGQVTRTFKEHTGPVVGLQLSSDNTLLVTGSGEFVVMVWDIEKGEIVVRLQGLMAPVTCLALTSNDAFLAVACEDETLRVFSLVSAQELHELTGHESRINALVASADDCKLFAGTRGRVIVYDIHNGQLLEVLQCALERQPISSLRISDDDSFVLVACGDRIHMWALDSIERDVAAVQQQKMATTLSVDAAQPTTSQSPPATTSVSCVQIAPDEKSAGCGTADGIVAFWDLDVCQCMWTSNAQRNGAVSALCFSADSFLLLSGSEQGTVSLWETNNGQLLKQVQLHADAVVALCAFADGVRVLSCDSADNAYLWSLGSLDESAAGKRMELIASIAHMHPPLYVRLSDTVLIAQHGANPREMNVWSVSGDRLFTRSKVHHNEAILCYGVNRCGTVLCTGSQDLSLKVWQMDSGGLLIQVLVGHEDAPTCCCVSEDALAACSGALDRLLIVWDVQTGAALHALRRAAVQCFIEISMDGSVVCSNGWVEAWHYKSGRLLSAFNTHRQVEQLIMGADGDRILAKLAGTAQLPIICLHNTPANLHSASASRYERVVLPATASTALDVSPSAPAAKSVVTVEGRPLVLEFSTTTTAAATEDDDDGPMPLGDNVSTNEREEPVTSRASEVEAHANKLRDAEEEQKRRRAEQVPNFDDALAPTAQSAAASAPPSGGADAAATAAASADAAAAAVPSTSTPAAQKERRTRRSKMCSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB00</accession>
    <name>A0A914IB00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IB00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g853.t1">
        <property type="protein sequence ID" value="Gr19_v10_g853.t1"/>
        <property type="gene ID" value="Gr19_v10_g853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF130">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g853.t1"/>
        </source>
    </evidence>
    <sequence length="511" mass="59331" checksum="4F04B817095E18A1" modified="2023-02-22" version="1">MLLCLVAVSLFIFAVCRLYGILSTHMRLKRTSDDIYNIADTIPFIGQAHVFPKNSFTFSSFLVEHANEAIRKGHHLMRWWCANKFFIFMMDGETAKIILESTVELKKGPDYKFFHQWLGNGVLVSDGDHWLRQRRMLLPIFHFSMLEQYTPTFNKYGRLLAQNLAELQGKRELVDVSPLLVKCALYNVTESVMGVQMDLEQKMCQKYMEAIKNFVIYQHIYALCPLYILFPVTWYLFGHGFATRRCVRALKAFSAKVVEDRIRINAANGGIKKDGLMHAEGSLYKGKIMAFLDFLLALKGEDKLSKEQVREQVDAFMFGGHDTIANVLMWFLWSMACHPEYQQRLHAEIVEHFGAEEALELTASDVNKLPYLDRCIRETMRMFPVFPVLERELQHDLRIGDQTLPRGVTVVILPLIIHHNEKVYPRHWEFDPDNFLPERMSKRSPYDYLPFSAGPRNCLGNRFAMLELKIILVHVFRRLRFSTTIPFEKNRPALEAVSRLELGCLIQVHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB67</accession>
    <name>A0A914IB67_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 11 RING-H2 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB67"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g897.t1">
        <property type="protein sequence ID" value="Gr19_v10_g897.t1"/>
        <property type="gene ID" value="Gr19_v10_g897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g897.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21730" checksum="8A122F1ED0B261E2" modified="2023-02-22" version="1">MEVDAADKNGSNCATEHQPQQQQQQRPFAIKRWNLVATWSWDVECDTCAICRVHLMEACLRCQSEAKAQECVMFFRRLLPLSMNCRRFSTSPAGFKTFEEFKQGYERDSSQRRRQSTFHLVRTIPVLAGIWVTFMVGIFYYWHCYYTYIRRELRRDVGPFSRFFGALFMDYTKYAYNTDPDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBE8</accession>
    <name>A0A914IBE8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ankyrin</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g9286.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9286.t1"/>
        <property type="gene ID" value="Gr19_v10_g9286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000095">
        <property type="entry name" value="Ankyrin 2, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000002">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
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    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
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    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="21"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="177"/>
            <end position="200"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="239"/>
            <end position="271"/>
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    <feature type="repeat" description="ANK" evidence="9">
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            <begin position="272"/>
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            <begin position="536"/>
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            <end position="1117"/>
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            <end position="1236"/>
        </location>
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            <begin position="1499"/>
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            <begin position="1879"/>
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            <begin position="1"/>
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            <begin position="27"/>
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    </feature>
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            <begin position="1235"/>
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            <begin position="1885"/>
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    </feature>
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            <begin position="1920"/>
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        </location>
    </feature>
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            <begin position="1962"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBZ5</accession>
    <name>A0A914IBZ5_GLORO</name>
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        <submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="Gr19_v10_g9203"/>
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    <sequence length="241" mass="27389" checksum="E7E3C12A0D5970E4" modified="2023-02-22" version="1">MIGSNNDELQTFLKAYKCSSEDQSERPPIMYSFGILPNYSEEIIGKLGHSASKISSISLNTDISAASKQNFNLLLKLSEIELTPFSILNLAKTIEFDLQSLLTFTENTKQFPAITRWILSLKVEYSKNCEQNDVRKINEHQDFLHFAEAVHVNWNPYKELLIALKTFKYVYLCSETGLGYFGSIIERFDQKLLNDLVKEARECLGEVKSTTTATTTTDNLEKAQDEASSRAKRTPHTPDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICC9</accession>
    <name>A0A914ICC9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
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        <lineage>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
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    <dbReference type="WBParaSite" id="Gr19_v10_g8900.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8900.t1"/>
        <property type="gene ID" value="Gr19_v10_g8900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="50"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8900.t1"/>
        </source>
    </evidence>
    <sequence length="568" mass="64370" checksum="37B692A1779BB3F5" modified="2023-02-22" version="1">MSSQQRQQQQLSGISQSSQFEISDQYRSDQFKDFVRTCLNGSHKDSLPFPHFAFTDFLANSSVLSDLRRELQSAAWVPKCNDLYSLSQTVDLADFQSDHYPTLCSFREFMANEVRKWLMVVTGVSLGERMALTGSRYSSGDCLLPHDDKLEGRAFAFVLYLSPDWNESDGGLLCLFDSDPAKNYPTDVTKSIQPRENTFSLFRVQHNSWHCVSEVLSEQKQRLSLNGWFHYPPEVAVVAPTGPDSAVEEPVARIEPSMNITLAEVNEWLSSNYIRPGQHRQIKRIFAYKSELSLQQFLNAERYNSALNELEKAQFECVGPPHKRKVWRLVESSLEQHSVLLSLLRLFRSEAITLLLTQWTGLHLYDLKKTKREEEPSPKETGGGPAEAGEPLKKRRKPGEGEGTTSRERATEEGNVTKKVQIVSYIHRFEKGCYLMADDQLAADTKNNGFCLDLMLFFGRKQECSAQNGGFVSYFAVGETDEIMRVVPSMNTAAIVFREPEVLNFTKYMNHRTGDDRFFVLSCSFFGISTGESESESSLNSAEEGEEEEEEEEFEDEEEEGEGGGTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICW2</accession>
    <name>A0A914ICW2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9675.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9675.t1"/>
        <property type="gene ID" value="Gr19_v10_g9675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="219"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9675.t1"/>
        </source>
    </evidence>
    <sequence length="1141" mass="127419" checksum="46FC6ECB4AACFEC8" modified="2023-02-22" version="1">MPSKQQRLRKMGKEQRLTDQSVSPGSQIPNSPRLDYSADGNEEASLGTTRALQISTPASATGKKRGRPPKAGNKGLVAGLDCVSLADTPNSTVPESATSSPCLKKEKSFEFDKKVITEVVSSTPVSTRGKRGRPFKKKGGPGRGKTVDSMSESSIMDESFVGNETMQVEEPLDDVDANLKLEKVACTSGNVPKHIDFNVVHINFAETRNFNCRIWRWAAIGLYADDDTLSGPRFIETCWNNPKEWLNDGFISMYLAYMASISQRKVVVLDSIVFDAAVSRVRGSYRNYTFGFDPSTPAEVILMPINFPGHWTILVNDIEAGTFFADSLQMSTLDTQKSNLIKGIIAELSSTTLESIRIDYVDNENLTPQHDGFSCGYFVCLYAEAWLMSQKTFILKNLNINFEKKRILWHLNELYSSDQVPYNPREGVTSPCPFVKRLAMEDVQSTSKILQSNVQLNDDSDDDIIIVDSPAKEKKADDIFFIDPPVHEQAVHPASAAMNAVLAEAEFPGENQADELALIVESCQAQEPIAQAGEVIFKRPKTPPRRSLRIKRLSNSLSRSPSPAAKRAPPTKGLGSTTRLTKRCHMVHKGWHCAAAAAKHFPDYFDSGELGEKKCPHCGAHLFQHEDSNICCRQGRVELPTLNPHPDELKQLIVADNQTREGKEFVRNMSRYNNLLQFASVSAGHKPCPAGGPMAVILNGEFHRRISSMQAGSTQTPGFGQLYILDPAEAMEQRRNNPTFTGEKITTNDEFVQGHKLNEKTLESLEKMIQENHPAAKAYKQAREQIQDLLKTQNAEELRFFRMTLLTERRAPAAVKDPKLHPNQIITPSTGEGMFAMHADPSGAPPPKGIWVENKQGQLNEIAPFSPWTDSLAYPLIKPLGDDGYTTGIKYTKPASRKRKSDVSTDHLFDSDVESDLESCAADSDASSDAGSIASGTSSVSGRFGKARQFVSLRDYCKYYLAIRDADVASGYHHILTCGGGLGQRWILDQAAKIDWQIATFLRRPDMDLRISTPRNLLQYLINQYNKQKARQNPNAERKSVDDIGSVVRLSEKNVNSLQYWKKMYEDCNTIFARYHDAKKARLFITFTNNREWTEFKQNLYKNAKLLFSVKNFMRKVTLEQSLDLANPWSFKGVEVHTPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID48</accession>
    <name>A0A914ID48_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mos1 transposase HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID48"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9745.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9745.t1"/>
        <property type="gene ID" value="Gr19_v10_g9745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9745.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16862" checksum="564ABFAC0219ACEE" modified="2023-02-22" version="1">MDPQVDKNEHFRHLFLFEFNKGSKATEAAQNICAVYGEGATNERTAQRWFHDNARPHTANLTKMALQELGWEVLPHPAYSPDVAPSDYHLFRSLSNALSGVQLEDAAALENWLNGFFASKPPAFYKRGIEKLPGRWEEIVNNGGEYIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDI6</accession>
    <name>A0A914IDI6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDI6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9853.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9853.t1"/>
        <property type="gene ID" value="Gr19_v10_g9853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="62"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="297"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9853.t1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55908" checksum="CE7A121D7987E400" modified="2023-02-22" version="1">MINRFIRNFLNGQHIICKVPQVQAVHVTFLHQCAKNNVCPAAVLSRVARMASSSSSSNRPSHRSKLLDDYHNRRTANLQLADLGKDAVAFALDPHGSRFIEQKLERANPTEKAQLVDALRGHVLTLAQQVYGSHVIEKALKSIINEILAQVIPLSFHKYGSRVIERMLEHCAEQQKRPVLEQLLDNVPTLVTDKYGCFVIQHVIEHGLPEDRARIVRSLQGDIMKYAQDKFASNVIEKCLTCGTADQKRALFDNICVGGPQTLRNARQLMADEFGSHVIEKFFEYGTDDQKAQLVDALRGHVLELALQMYGSHVIRAALKSIIEELTPRSKRPVLEQLLDNVPTLVTDQYGSYVIELVLEHGRPEDRERIVRSLQGDILKNIHRRSICSIIEKCLIFGTTEQKNALIDQVCADDGTGKPPLLQMMKQQFAADVVLKMVDGADSAHRDKMVFAIEEHIPALLKRQQSLNTVQAKPRDERRTVTDKRKKRRNGLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE66</accession>
    <name>A0A914IE66_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE66"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9063.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9063.t1"/>
        <property type="gene ID" value="Gr19_v10_g9063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036908175" evidence="1">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9063.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="8408" checksum="25592FA9DF258285" modified="2023-02-22" version="1">MNAQKTIIVALVIAVAMLSMEVPSVDAQCCVSDGNGGCVSPQGCCVTCLPLGSDCFCADGANKTPNARNAVEAAAATADGTAAGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE95</accession>
    <name>A0A914IE95_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE95"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9808.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9808.t1"/>
        <property type="gene ID" value="Gr19_v10_g9808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9808.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9656" checksum="497F0E1BDAFD1910" modified="2023-02-22" version="1">MHIPRSWDKQSGSSVSITINAKNPQLVHDCEEFGTHTQVHATAEMKGPTKSEQLFESQCLADKLVLVHLFEHAYLLIALNEINNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEK5</accession>
    <name>A0A914IEK5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEK5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9499.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9499.t1"/>
        <property type="gene ID" value="Gr19_v10_g9499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9499.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27560" checksum="7F9BF5BE1D316C11" modified="2023-02-22" version="1">MALISDRLDRLVDVHFKSRKWSFGWLKIIRATDVNGAQIYTNALVNGSQLLKNRFQANFIDQTVIEFLQRICHLFNSPGKTIEIYIPDDQSRSWEIICQQIWPLINDNIYNFCLISDHARLQQLSSVILCNCAKLELIGAYGRLLNCQPKTTPAFVNAYEPANFIIRTNLGATEPFELKNNLMGERLTLRQIDEDFWLLWEEEAIEWDPQWNCISIAFKDCDIGDEMLNAKAGPSATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEX3</accession>
    <name>A0A914IEX3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEX3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g926.t2">
        <property type="protein sequence ID" value="Gr19_v10_g926.t2"/>
        <property type="gene ID" value="Gr19_v10_g926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g926.t2"/>
        </source>
    </evidence>
    <sequence length="187" mass="21575" checksum="6A04A0690C4222E4" modified="2023-02-22" version="1">MNKERVVFYLRENIKVQKQILYYKRRRTLARIRRWPAAGFSKMHGFATIFFLLWLVPSVLIVYGYQDYDPYNTVRKEEQIYHGRRVRPVADGVLENGGDRAEKALGELRERIEDAEVIEPHGRNRRESLLGLDVPYKAPPPAGEQQQNRDGGSIGQQNKAGGNGGARFRENSMAKEQRGKQPKLFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFU1</accession>
    <name>A0A914IFU1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alkylglycerol monooxygenase</fullName>
            <ecNumber evidence="10">1.14.16.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:36255"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="ChEBI" id="CHEBI:73418"/>
            <dbReference type="ChEBI" id="CHEBI:83957"/>
            <dbReference type="EC" id="1.14.16.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sterol desaturase family. TMEM195 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.5" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914IFU1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9513.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9513.t1"/>
        <property type="gene ID" value="Gr19_v10_g9513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056853">
        <property type="entry name" value="AGMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF4">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24858">
        <property type="entry name" value="AGMP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="15">
        <location>
            <begin position="68"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Alkylglycerol monooxygenase C-terminal" evidence="16">
        <location>
            <begin position="306"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9513.t1"/>
        </source>
    </evidence>
    <sequence length="453" mass="52842" checksum="9D1A06876705B5A7" modified="2023-02-22" version="1">MKLPSPHWSRCQITTHRSVSGGRCCSCFAGMLSQCFKFGGRAVAIFGYVWVWDHFRLIELPWDSTWTWLLCFLTQDLAYYFGHRAIHEVGFFWGLHTIHHSSEYFNLSTSFRQAAIQDAGLAAHDILQALFIPPPIFLVHRYFSEIFQFWMHTSLLGSLGPLGFVFNTPSHHRVHHGRNAYCIDRNFGGVLIIWDRMFGTFEAERMDDPPVYGLIRSERSFNQLWLQFHSLKELLCDKWRLKDEKGENVFPGCTDKLRALLFPPAWLPGVKVRLFFHWASLDDHTHGVTPIELPVQKYDPPLSRWLKAYCLMHFLLLLTMFLQFEYDRGQFGYVEFSLQLIFFIYSMQSFGAFFDKKKFAPFLETLRLIGFIAYYTTRAVVKPDDVESPGICMVALFFVSAIGWAVILLRHLIRKRAKVAKMRMRFVGWNKSGRPSDMEAGDKKKWSGRHKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGT9</accession>
    <name>A0A914IGT9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGT9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9755.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9755.t1"/>
        <property type="gene ID" value="Gr19_v10_g9755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036733364" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9755.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="9939" checksum="EC583050AD1953C9" modified="2023-02-22" version="1">MVFLNVGIFWVHALLRTLPGSGLAMRLSLVAGASVCITVKCVGGELLDQGCVETPIFVEIERKKTSKIEISTQPCAGPVAVGRQTTAGQEPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPU5</accession>
    <name>A0A914GPU5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GPU5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10313.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10313.t1"/>
        <property type="gene ID" value="Gr19_v10_g10313"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g10319.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10319.t1"/>
        <property type="gene ID" value="Gr19_v10_g10319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10313.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10319.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="11543" checksum="56B73D1F7AB06963" modified="2023-02-22" version="1">MASNQELACIYAALALQDDGVPIQAEKIQAMVESAGVSVEPFWAGLYAKALQGVDVKALIYNISSGVGSAPAAAAVAAPSAGGGAAAPAAVKEEKKKEEPKDESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPX4</accession>
    <name>A0A914GPX4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPX4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1034.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1034.t1"/>
        <property type="gene ID" value="Gr19_v10_g1034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="267"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1034.t1"/>
        </source>
    </evidence>
    <sequence length="643" mass="72370" checksum="6F77E1F4A56352A1" modified="2023-02-22" version="1">MTTEQLIIPTEMANKIINEVDQNCFERWKQNGCTLEVKQKYSVQLVLNGIAIDNELLLSEEIFPVLKQTQDSLLDRYVLALKLLVPNQKCGYVIGKEGKTIRKIQEDFGVEIFIDNGKRDPVPTGFGRLIIRTADVDAMRWARDQIRRLEARSLDFNPYAMPRDNNNHLGEDKRATSERIKLPPFGHFTNEQQMHFREIQKSSSINWIFDEQHSLTDASGRFVTLEGDTEMVLSAKRRLAKLITEIEDFQLHCSSVRLSTSPTSGTTLYRTVVKVPTPAWRLVIGAGGKTIKALKERYEVSMRFLGDNYVAYPHFRSLSIRGPNQLNVQSVRAYIEREFVAKNSDFVLENNIVTAKPNVRRTFIFEDPNNNNKKNTDVANSKGHKAPISGWESDDDSWAAEDTHVCSDFGAEEQRDDDGSEETAQNSEDETLPKWDEEEEREGEQHVGHGGHDDGDDVAAAAAENKLERNGGAESVLERGDGQQTTLQGGDVKSTGNEESGLVDRGEEDELFLLIERKEEEKEIGAGRKVGQRVGGEHRNIAAAAVPILRRMTSLSDGIGNSCVSAASSGDSDIDEPLSRQRHLFQPLDRNMLACQLERAKATLLGDEQLARELARTQALLRSKERECEQLRAELQRLKQFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQA1</accession>
    <name>A0A914GQA1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQA1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10180.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10180.t1"/>
        <property type="gene ID" value="Gr19_v10_g10180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="182"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10180.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39423" checksum="DDDD3F00744A1FE0" modified="2023-02-22" version="1">MKRTRTQSPSSTDADRSRDKMYSQRGQILFRMPNFKTFVKRRERLVVVQSDTVDINGLPWTIGIATCKCEGEGATADPNCVHIGIGLRCLGDKTDMAWTCRAAYQFSVVSFKKSGECLLKRGELDSFNIFTPNHVSWYLGCAYTVEQLMDPKNGFYDEEEDTVTFKAEVVVEEPIGMAGVRYDNALLINGQLINVNKYLLAAHSKYFQTLFFGENAKESAEIQIDEVPDAIATFKKLIATMYPQNEELDDECVEGVLLLANRFLLDCVVNRCVDFLFKKSKKSAICKFRMAHQFGIIGLKDKTLENMTRQDFSGKAYFNNLSETNKLGVKEMEELQERHKELYESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQI7</accession>
    <name>A0A914GQI7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exocyst complex component Sec5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g10479.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10479.t2"/>
        <property type="gene ID" value="Gr19_v10_g10479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000196">
        <property type="entry name" value="Exocyst complex component 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2084"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="19">
        <location>
            <begin position="1239"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1381"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1429"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1598"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1729"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1904"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2164"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2220"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2242"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1406"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1449"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1606"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1625"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1754"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1930"/>
            <end position="1939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10479.t2"/>
        </source>
    </evidence>
    <sequence length="2301" mass="253994" checksum="7972D17A94BBC6AA" modified="2023-02-22" version="1">MGNNQGGFHKRERTGDGSQRRATGGGTIQILSSSSSSTGSHQNPLHGHPSSGADDGCPVQMKIAKPDLMSEDYVDFGHNEYPVVFKWHSEVQPAKHVYLTGSWDCWHKKIPLVKSSSDFSTIINLNPGLYEYKFLVDGKWMVDDAITKTDNQMGSQNNVMSIDKADFAVFDALDKDLASSNAGEAMRSMNSTGAAQPSQDTPNDRELERLREFTQQLPDRRDFEKATNPPILPPHLLQVILNKDTPVQCDPNVLPEPNHVMLNHLYALSIKDGVMVLSATHRLNQKYLSTQDNVDKEFAFTFCQILMSAPAAISLRANAPLVTGISPHQGSPGTLVTIRGERLGEDANDLVALIICGTDCLATAKWKSSSKIVARLGGQAKRGPGDIVIVTRLGGRGQSAVQFRVFIEQIGPLQESSVWVDESKTVPGRNLIRNVQESGDPEDVLGLGIDQQTKMDDAGLSRLFPEGTGSRKMENFSPAWHLLENYKSASVTDLKRGMANLEKRIAREEECSKNLHKANLFLLISCVDALTSLHSQIQAKAISEDWPITAKVTGKIDLAAKMADRLFRDVLTRKDHADSTRNALSMLTRFRFIFFLAESIEANMTKGEFATILNDYARAKALFKDTEVNLFKEVMAVLDEKIGQLRECIRSKLLDISTPFEEQSRLIKFLKILDPESDPAWDCMMSYHGWLENMLWELQIQFQTKSIEAQERAYEYKPPQHFRQAFVVDLLGLLTEKLQTFWKISQNFAVTGPTTSAGASTLSSTEVQQFQERQMDIDQMLTNTINVGSWLLLNALVPDALPESVNRQYKDRFAKWPRLGSNAQWEVMFPSIKTLRASIKTLAECLNRSHLQPLTELCTTIRLKCLGMLVERGKEAVLLLGAQENWRVDLMADPPRTALPDLFETEINELISDVKERWRQMIIDLFTVLLLGVRDCYDFLLKLRREQKRPNTLLDIGSFGSADEDGNRMSKQPQEQASRRFLVAIANIDYLINRSVSGICRRLSDNGVKFADQIFKRTKDKLVAYRLTLLGHYTAQKLSQVQSILDTANYTHLPDEDDVSDFVKELMLCAVFVQAEMAPFCAHFTEQVLADIVKVSLEQLFAELSRVDLSSTERSTQTIVDLTAFEKAFQEFITTDMRSALKSIRARLMPRLDNETFRNSMLNFRSGMTMAMEIICSHIYLYGQQTNISNPLQTTLLAMISQFLPKLSVMPLTFLLVLLTGIFVPPVDGFSQPEVDLHGPNVCTFEEEREKIVIKKYDRQVQLVTTQWCPDISKGFQCEVTVVITRCCKGYFQGHDDICEPICDPSCKKGDCVEPNKCKCFDGYGGDTCSVRCPLGSWGPNCRRTCDCEQTKNCDFVTGQCRCPAGFMGARCEEECPNGHFGDGCKSQCLCQNDGICDKTTGECSCQPGWSGKHCTHRCEKSHLEEGCRYECNCANGGECNDKTGECTCLDGFSGELCEEKCKDGFFGPGCKKRCDCLNENICDPKTGKCECVGFTGPRCRTPCQRGTYGLECSKSCNCDSEAKCERFNGSCICSEGFRGEHCSEKICPFDRFGLRCEQTCACNSNNTKLCHPLNGFCTCKPGFMGAGCNSVCPQYYYGDLCAQKCKCAFENGATCDPTDGKCICPPGYTGKRCDQKCPSGFYGIQCESKCNCQNDGQCDFRYGTCNCTDGWRGPSCSLTCWGQTFGHKCQSNCGCRNGAGCDPLTGKCHCGTGWTGEKCDQPCAAMTFGIDCKQKCQCENGGTCDRFSGKCSCPEGWTGENCDSHCDSNKWGGQCENECDCSGFGSCDQHTGRCICQDGRVGTNCAEVCPAERFGKGCQYQCEKCGHGQTCDPATGVCLICAAGRSGFKCEQNCPKGFWGVGCSEKCFCDADGGSCNSIGGTCECALGFTSKYCDQKCPAETWGFNCSQKCRHCLNGGLCSAFDGECKCPPGFEGELCQRRCSEGMWGVSCMNNCTCRSDRKICDAATGLCECASGLKGDTCDEYCDAGFWGPDCVKKCSCREETSTCQSVTGQCLCNPGYLGKRCEKTCPSGTYGRECKQTCSKCPEGQICDPVVGCCSPNLGHCGIAYAEQQGIQRSISSYFWSGLLLLLALSVALIGFALYYRRKYQKARDPPLPTVSYNGGDYASVNGANSNGTGTEPKNQFENRLFDEPDMEDNLAINPQKEKALFRNVPTRPENEYATLDGPDEDFGYAEAGNGTDGRPSSSSVDGMRRSSPRRQGSDGTSTQHIGTLRLPGQATPPSTALINPTNHGRPVGDGSTRTSFDALDDHNYEEPVLMLNTSKQIAADNAKGGGNIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRT1</accession>
    <name>A0A914GRT1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914GRT1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10160.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10160.t1"/>
        <property type="gene ID" value="Gr19_v10_g10160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF7">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038164904" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10160.t1"/>
        </source>
    </evidence>
    <sequence length="582" mass="66758" checksum="2D83BA593EFBC365" modified="2023-02-22" version="1">MSKPLTSLGIFFVVLVSVCAALQFLPWHRNGWWRGSTDAETARTSHNILKQKVVGDDEIAQFGRDTDYTYKSVCLVDGKPTLVDGFDCRHQVAVGRYKNAINMTGWSYLEIETKPEADPDMQAYAAGVLEGILTHRVLDLHLKNVIYDYCTDYQTYCNKLKAYLEQNLAYVQERLEKAPEDDAYWQGVKRAYLQVTGVWHGFSGAPFNVSIDYSLHPILMLETKFNRSKDPKDEGTGGRCSGLVKVAPNNADILFSQVTMCGFESLLRVLKLYKFGYDRALYPGHTTTISSYPGLLYSADDFALLSSGLATLETTMKIFNNTLLGEITPKGVLHCWVRAIVSNQMARTAREWCHIFKRYNSGTYNNQWLIVDYNKFKPGKELPEHGLFYVLEQMPTLVLYQDLTQLLKEKRYFASYNIPFFTRISRISGFEQKGNDFYWFSWKTCPRAKIFARDQHTVVDLDSLTKLMRYNDYTHDPYSRCNCTPPYTAEAAISARGDLNPANGTYEMPGMGHANHAALDYKGTDYKMFKKLQFRAWSGPTYDDVPVFDWRDSDLAPTVKHFGQPLRWDFLPVDYEWETLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRT9</accession>
    <name>A0A914GRT9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRT9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10805.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10805.t1"/>
        <property type="gene ID" value="Gr19_v10_g10805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218714" evidence="1">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10805.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11726" checksum="3CBA04F2BDB76F42" modified="2023-02-22" version="1">MKRVPPRGRAKPFLALWLGTARLVPSRCTWLMAQKMQLVKLYISLGEQLASFSVAGATSVGEVQGGWQNVRRPVHYVCVSSTIWVVMRAKKLWGGQRAASTGADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSD6</accession>
    <name>A0A914GSD6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g10935.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10935.t1"/>
        <property type="gene ID" value="Gr19_v10_g10935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF224">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="3617"/>
            <end position="3639"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="50"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="373"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="670"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="725"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2249"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2352"/>
            <end position="2391"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2393"/>
            <end position="2435"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2443"/>
            <end position="2482"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2556"/>
            <end position="2590"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2594"/>
            <end position="2636"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2638"/>
            <end position="2680"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2682"/>
            <end position="2722"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2724"/>
            <end position="2763"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="3010"/>
            <end position="3098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3700"/>
            <end position="3744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3904"/>
            <end position="3958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3709"/>
            <end position="3719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3722"/>
            <end position="3736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3930"/>
            <end position="3946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="3949"/>
            <end position="3958"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2276"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2362"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2381"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2425"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2453"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2472"/>
            <end position="2481"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2580"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2626"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2734"/>
            <end position="2751"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2753"/>
            <end position="2762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10935.t1"/>
        </source>
    </evidence>
    <sequence length="3958" mass="434832" checksum="F8D758A8E4D6EBB4" modified="2023-02-22" version="1">MISNKTFKHLAPFLCQILYQTFGIFAEEFPYSIGDLHTFCPDSKDFWHSVGVNCFKMTPIDQRMDWAEANAFCDLSINNHSDALHLDNWLLHRDLSRKFLLQRAQNGQNEFWTAWYIEVRQKKLPEIIHRYGSSQNSSIYNPAWASLEPHLANSESGRWCISWGAALLDETNFGWHLRNCTDQLPVICQTFACYLDGAGLPQHRCADNSACISRRALCDGVSDCESGDDELAQNCDNIAAQKCDDIEEIFTKLSSNSYGDIFPIGWQIPVTKFKPKTCLAKREKWLIDQKPGARIKLDFLALQLGPNNRLSLRDLDTGEHFLIRQSDDKFPSILGANRLEILYERFETQNGDENVAERRGFHLHYAVDDANVCTRTFESWNGSFVVPMNVPDTGRYRTPMQCQWTIENRNRGIVVVKFPVFRLSPGDWLGLVLDEHSAHVGHNFSSSMPAPSVLVTNAPRIQFVFSANNSSAGDAGFRAVFQRSCTDQLISSSPSGNVQISLKKAIADGPVNCSMRIEASKNGPFSLFIDYLNASENDKIYFLNSDGHGLDNKSFVGIAKEFRSFTSAVLLNFVLNSSSLEANIAYSIDCDRPRLWHSAHQMAPNSNMNNSLSKKFERLVQNYLPFRYRIPSVPCHNSKGNKSAELICADGGNLVMSGCSEDGNSAVPTHICIVPRIKNGHATELNRQLGILRYRCNSGFASMQAQQSICTKSGQWIPEPKCSEIRCADPAPNVMPNLAFFHPPDRYEPAKLDYRTLSNRFGNLITYKCGNGTMPRGRRSMAQCSANGTWTTVEIACKKIGCYAMNVELGNFSHFWTLPGAVARIECAHGTKLATQNLPKCILDGNGMAQWEGIPAQGIKCQFENLCKRFGQNPCGPTGICIALNGTYSCNCTSPTHRFNKSASFGEQCQALDECAEGRWPCSSGTCNTTSHPLGRYKCVCPPGTHFLYDTKNKTKNNLIIPATQWLIPGHSCIILRCPTIRPLSQLFVVHSSQPQHPVNSTLVVYCRHNANSALIGPETELKCLPNGQWNGTMPTRCQKAEPFCQAPLMPNVATRIRGQKFAEYVVNSVVEFGCVQWTHNRQKGSDFLMVGYNRSICLATGNWTNAPPTCILPQCSKIALGIRNDGMHISLTSGQKWPTNELFGPGAEVKINCAKSGKNWTMICKRKANFEMVWSMDEMPKCEVNTEEVAVVGTCDMTKLAKISRDLLIASRDSVLVGQEVFFKCAQPNYTLSDQKARKCVKNSGKRAARAAVDEQLPVGDLPTGDQWHELIKTAMPESDVIFDSVHRLYGWQKSNHWTQNVANGSWIYWPSHHGKSSLITPSMEVSAGDWLSVSVELGPLPCSNCMVWISYFAADQSSSAFPVEHFNSLGAIMADPVIHSIQFFSPHPKLRIQISADDKSPNFLVERVKLISTACPALNLSPVTNFPRTPAHFENQTISAQCQLGKTLRLICSPLGQWLLPENEPLAYGCGCQPPLALNSHGKCGIKEALLCHVCSSDTDTACFSPTGAEDADVARATAATITKRCTSPDELCMSQSRAHRAHGTQVPFNIVRRCAERAECGIFKRNVSARESCRTDLDGVETCTICCSDDLCNGARPRQLLNGGGLVAVKSLMALSSSTTTTTTITTTLSTPTSSVLQKVTTPVITSSSSTTTTSPSSTITTITLPTRTAQTTTTTQQIPIATTRPSSTSITTMPSSHFVLREKQNSDEFELNSAPPICVDQQPLDLRCLAQIRIRHRMDNGQPEPTVIPWPNVIDNDPHFHLQPMNINISKPHTFMGDEKEIIWRAVDLHGVVKICVTKLVFDGTSSTNERQDLPKGIDIECPDWHIREVNVSAEFGGDPLTDGPPMIRAKYPPIATKKPDELSFDPPVGTHLALGAPKLVFVRLNGIQKCQFWYQTLSIDCPLWTLGAGNWRKFECINELNGLMRCKRNQPCPGGREYPRGMRELRCWRNRPGHGLTYTTDQKSGENEEISLIGEAQCLPEASSLVVMLSIVVASDNANCTKLMARQMNSFLAQNCPGIQWSSSSTNADLAHSNLTGHNFGTETTDGGNDQSVVLCIQRVSSSSRLGRPTFSGHLDMPIVEGQQCPDGSVQTRHFSYHLQCPNGWAPNELLRCEMCPKGHFSSNGTCAQCPAGTFALRAGMTKCTSCPEGTSTVGNGTVADFQCLTRCAPGTFSSNNGLAPCRACPTGKCQQFGKSQKLAESLANSEMPQHFDCTLTGCSGHGKCQNGICQCDLGFVGPDCSILLDLCSAQFCLNLAKCVFDSSNGSSCICSRGFFGQRCEHSAHSNRLTTTDVKHLSTTSSKMQNGICKESNEINECPNGFCLGGFCQCNAAFVKSTNENGQICVPINACLATKPCQKGATDCLHDSNGNVQCVCGEAWAGELCEQQSQSCFLPQNQCLNGADCAWEIKNSTLSTRCLCPVGFNGERCEHQNDQSDLLEQCQHEHRCGTNGSCQLNNSIGILFCRCDRGYFGEFCEAELNPCSSASTSPLICYNGGICQPMTSEKAVCQCPQGYCIGAHRGSAHCSCPEGYGGDSCQVELSPCTKWPEGDAGICGNGHCLAKGNGHNAKFECLCSNGWTGPNCNIPLGAKECEKTTNKCKNNGTCVPLIDNGIQKWTCECSDGFWGNRCEKRVNYCALNGICLNNGRCKSVVGGDNHYQCECDGKNGFFGQNCEQTAKPCDRNPCANGGKCSPNYADPTGFKCECGPNYVPETNCTRKLNPCHWPNYCNGGQCELLPNSTDSPHCICPPDSMGIRCETRKLSHYDLHFLPFLNSSSSIIQKIRSPSFSCLAITQQSFSLCFWLRFGQTDGQTNKAFPMDLSRIIYISVNELNSADIKNAQRILQFDQFGVNIFDTKLQFDYGHALISHLWHHVCLTFDTAIFRLFLNGHFVDARSGKNFSKNHSKNFCQLLLGEHIGEEAAHFVGQLSQVELYSKRFDDAQIVRMAWNCREWTHRQEKTFSIVEWAHFTTVDVFNKAQIALFPGICSESDCQPGSESDCGHGKNLKTPPEVLFCPRSQFITVPVPNQRLIQIQWEGSLEKMFRPTGTSPIVRFESNFRPGQTFGWGQFHVVYLAEDALGNWATCEFDIVVSPTKCSDLFVPGTFNKLTVHQFRVEEARQAEKSINLKCLSTELVSNVVAKPPFYTCDRLGQWDRWANFGRPFTLPSCTPTENAMQEVVGDLHFDATCDEAANYVLKVVETIENASKNAGAFCERPQCAGQLGIKTECHGEGNGGAVDNNDPDVPSLLSGAGNRVRRVPPTGQQQQTAVRVLFDLSVNNSKRAVAPVIRDAMEAKFGSNFVGETTRLQCSNAFPQLHINGDAKIAGSASVAMASDPPLVQCATCAPGETWQQIVRKIATTTKDESVVNSDMSGSCVKCPANSYKSSPGVQPCTPCQDDRITGGVVGCMREIDCYLNCPPGSVYCSMTDTCTMCAHGQYMPYSGRLQCIGCPPGTTTEQEGSTSADQCSVRCALGEELGAGEQCEMCTRGTFRAEGMHACRHCSLGFTTRSSGAKSASDCAHIFCPPGHFRNTTIGPDHSDNQLISSLASVCVPCAIGYYQECDQANDGTCKPDEPEPCPDGMECVQTRGQTYECHNLPNINRTDHGDVWRRVWIPMILALFAVLALAVLSIIFIKNRQKWLLMLNRHCPCTFLLCCKKMTVDNLASNEYTRTSPPIVTEISQNVQQQTVVELTAASNENSRSSNTEKSKAHGHDIVASLRPRSASESASSRSNEKVDDPLNEIRSGLMEVMNATELDDGDESNGSSSSHRLTETFGRGQQYFMPTSSRRPQLTVQTRFPITPNENDTIAHHQQTFHRRFRRSFSSSSSSSAVDEPPLVRAVPIHHRDGRSFLGSARATDAIGMRNFSMGEEHNEDGTHTLRRPGGVLVGLRCRQFEPGAGVAGGSVPLRSSLTGRSPLASPAGKSGTSSSGVVPAEQTTAVPSYDDDDDAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSS9</accession>
    <name>A0A914GSS9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSS9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11040.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11040.t2"/>
        <property type="gene ID" value="Gr19_v10_g11040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11040.t2"/>
        </source>
    </evidence>
    <sequence length="167" mass="19168" checksum="A22EF4BBCCCBE67E" modified="2023-02-22" version="1">MEEGSVLFVLRKDTGGEASNANQPHDNTHRPDDRLIQPQQGNFFCSKFLTKIVKLLNISPFKFVFFSDGAYQRHYRSFKKEYMRTNPPNQQATAWVAPSTQSPVNAPAAPPNLAWWENIDDSSGSSQSVTSRHTLEQEPKRKQKRKPKREKKEEQHQLPITSHAVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSX4</accession>
    <name>A0A914GSX4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSX4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10093.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10093.t2"/>
        <property type="gene ID" value="Gr19_v10_g10093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10093.t2"/>
        </source>
    </evidence>
    <sequence length="111" mass="12942" checksum="E7DE07F7AC4726BD" modified="2023-02-22" version="1">MDKNLVFWKSCMDQNLVFWKLQGPEFGVLETARTRIWCPGNCKDQNLVFWKLQGPEFGVLETARTRIWCFGNCKDQNLVSWKLQGPEFGVLETARTRIWCPGNCKDQNLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTX4</accession>
    <name>A0A914GTX4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTX4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11205.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11205.t2"/>
        <property type="gene ID" value="Gr19_v10_g11205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22382">
        <property type="entry name" value="KH-I_SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000126">
        <property type="entry name" value="Protein CBR-SFA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="210"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="664"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11205.t2"/>
        </source>
    </evidence>
    <sequence length="732" mass="79938" checksum="D954E14FBCE2F52E" modified="2023-02-22" version="1">MKSTGGNLEPMPFVRKWGAAVDGENGAEGSQLPTEQCDDNGKHRNRSRSKSPSSKKHKKRSSRSPERKKHKKRSRSRESKHRKRDRSRESKRTKDRDEPQQQQNISAFPPPSDYLQQVQQRHQQEMQHLQKPTPIPLMQLQFKQETDYGGMEQQQSYGQLYQQDFQQPQQNARQSILQSQHELEQQEPEKKNDALSAALAAAAMVAQKLGKGGFTPGGGGGGGSGGALGSSADLLNRIPQTPQRATPISETVLAKEPVKNEPEQTLTEEQRQREQRRKSRWSTTKAFVPGMPTILPSDIDENQRQVYLFQMEIEETTRRLRQSDFGQNVDPAERSPSPEPVYDTTGKRLNTREVRKRQEIEQRRHEKIQALLRLNPNYKPPADYRPPNIKLHDKVWIPQEEHPEINFVGLLIGPRGNTLKALEAETGAKIIIRGKGSIKEGKLANRTGPLPGENEPLHAYVTSTDREAIKRGCDKIREIINAALMIPDGQNELRKLQLRELALLNGTLRPEDVLSGARCTNCGSDQHKTWECMEAPNVTANVICTACGGAGHIARDCKNPRPGFDGAMMDAEYSALMAELGEKPPISLEAGTAPPLVGGKPIPGFPGSGPRPRFALPAPTPIPIGGGGGYPGWDGSNFYGFSGLPGQDPAAAAAAWAAWQAGQSGFPAPVPPPPGGGFGPGGVDSSLTAGTSAGGLAMFPPPPPPPPPAPKHEIKEEFDSILSAPAPPPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUV7</accession>
    <name>A0A914GUV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10604.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10604.t1"/>
        <property type="gene ID" value="Gr19_v10_g10604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF12">
        <property type="entry name" value="TRANSLATIONAL REGULATOR ORB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="275"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic polyadenylation element-binding protein ZZ" evidence="4">
        <location>
            <begin position="346"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10604.t1"/>
        </source>
    </evidence>
    <sequence length="417" mass="46081" checksum="58CCBA19B43797A4" modified="2023-02-22" version="1">MIYSLSDLRSSVGPFSAPLSAPPMAISSSVDAIGTRERDHQFFFGRDFNEMFESLSLQDNGKSLASSSSSGILNNFSPALVPNNVYSLSDLRSSAGSFSAPLSAPPMAISSSVDAIGTRERDHQFFFGRDFNEMFESLQDNGKSLASSSSSGILNNFSPALVPNNVYSMSDMRSSVGLRETRIRKPQPTHFSLKVFLGGIPANMTTRYAFVVFQEEESIFRMLRLSFVSNGRLFFYVYMLGPEQTQHPVEVKVWEMKDTMHVGIIGWRKFRRYSVFVGGIPRTCTAAMLAYGVQEVIGPVAYCTIELDRQHCYPKGAACVVFNSKESYIKAIAAHDVVLSFGTFERKVEFKPFLATNMPCEKCGCTAGTRFCAEMICLAYYCSNCWKFAHSSRPSLSGHVPSKRFGRGSSTNSIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV00</accession>
    <name>A0A914GV00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11586.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11586.t2"/>
        <property type="gene ID" value="Gr19_v10_g11586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11586.t2"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116653" checksum="84973D6C0893AE38" modified="2023-02-22" version="1">MEHQGAIFLANPIVGQPGQNQIANQNETVVRQPVAGQNRALPRGVPAFQQNVNHQPQQQQGVGVNGAPRAQNIVFGNIGNAGNFVPVQFHPPVQPQFQTQAFAVPHQIQTGLAPQPWPTQRTAQEQQSEMLLELHRVTLSNQYASVIKDLPTLYGAEGRDSVHDFFITMESCTREWREEKKMDALRTKLKGKALKALNMAFNKFGQAAPYSTIKAEILSILRETDHKEATAFAELTQFGLRNADEDITKFADRIQKLVRCAYTGINDVQLDEIAKKFFVLNINDRDLARFLECQNKTSQTYDEMVMLANKLNLLDPEKAQAQIEGKNRGKVQQRENTGRIDIRAQNQSNFENRSRPWHQNRYNPNFRSASYAPVREPYQNSSPNYQPQHSSRSNQPQSNFLPQHQNYQPPGFNPGQNRGYQNRNYPIQGTGANTIPLNSGQKNSNIRPQANSIVIGNPVGEQSETPTVKVSLVGQCELSECEKFFHLLATHASEFPSTNPAIPKTAECISVEVKVDENKAKALIDSGAETNVVNPAFLHKISSAEGTNLMEWGFNPNTGSTKIPFEVTSFTGSRISIVGAINVPITRGKITCEVPCLITQEPFSYDFVLANPEDHSKYIIENIMENDNISLDCSDCEEEFEKVKQMSKEQEEHELVQLGILAGDKLSVHRSKSAPTKIDLSKLPIHQCRIVERMLVESDDEQLYGLEFNSLGQIFCSLPDDDPIRRIRVETLGELISLHLAKDKMFCQALEDVRAKKLYGKVRTVRSTFAFFGDGATEMLGEKLASEMVLGKNSTELANSISKLSFGKELKEILVAFGTSDLNEDIPLDQTKAALQKILFHLGKFSVKVLIIPPPFNLAKKPEHEKLLKMFWETVPKEGKIQLALIKEFRSLAEVTRYGAEEEKRNVQADGKFKPCGVRETIKFLREVFGMITPDKAFTLPKPVAKNVPSHSVEAQNYQFRVSGPRPLTSIQPAGPRPAFIRSGTDSARGHFRRGSQNFTFVTPKRGRVSTFVDEDATAEGRGRTRSQLPDRQIATEDSGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW51</accession>
    <name>A0A914GW51_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Signal transducer and activator of transcription</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GW51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1173.t3">
        <property type="protein sequence ID" value="Gr19_v10_g1173.t3"/>
        <property type="gene ID" value="Gr19_v10_g1173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09919">
        <property type="entry name" value="SH2_STAT_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000493">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47655">
        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="STAT transcription factor all-alpha" evidence="13">
        <location>
            <begin position="183"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="STAT transcription factor DNA-binding" evidence="14">
        <location>
            <begin position="372"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Signal transducer and activator of transcription linker" evidence="15">
        <location>
            <begin position="540"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1173.t3"/>
        </source>
    </evidence>
    <sequence length="851" mass="96423" checksum="CD917B0FF4C1B6D2" modified="2023-02-22" version="1">MIGRLRKLGIIGRWQLAMRKLLLFRQRLPPFGLWPRLLRAAAVSTPLVGDDYSSPIIPGAFIRRPLWQQQLSGRVPIELGCCCSKQVISLAAISFSSPTVAAGDNPARERRKEKEKKEILVYRQSQYRSGSPISIRQMQQLNPVGGCASVPTPAAFCSGASPSSSVPPSANSTEQQRTVLMTLTKDCQTLWEQNKDMQGRFVNDLTELQRLQLAISQLEAEQRHDQLKQTRHQMMEMQRRASQLYEQLTDRRANLVQRLNDGVQLIVLMQSQLISERLLDWKNCQKLSQIGVVFEQREQILDEIQSEFEVLAENNWTLRACACWQLDLLKRSPRLSDSQSVQSHISNLTYILETLTKLLCMLVTQSFVVAVQPDPVLKTQHKFVAEVRLLIGERLGIKQQLINTNVTVKIIAEEEAKMLSTGQLNEKDIKTVGSISNDFEKLVLDERGHMAAKFNNSKLSRIAHRKPPAKGSLQASQCAQTATDQKYALLFHITPFQLGNLGKFDVWTLSLPIMDCDAQAVILWQRAFSSVNRTNASDDVSMVAWPDLSRVLRHKFFLFTGANRPLSESDLAYLGDKLGMHSHGDNKPITFQRFAKQNLRDDVNFSFWEWFFLIMQLIKQKLLKFWDEGWLVGFISKQDTSSQMMMCPNLTFLLRFSDTQTGAVSIGFVCEEDGMKVPFHLAPFTIKDLDQLSLASRIRNCPQLQEIRYLHPDIEKEEMLAFFESEEQRLRANETSPTGYIGSEIVMVAKTAGCKLNSALGSDSPSPMSNQWSPGELQQSNSMEISDDIVSMLNQNQLEAANVESLLGFQVGHRMAVDQQQQPMPQLDLSFMDSFSVQPNAVFLMGQQRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWT9</accession>
    <name>A0A914GWT9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWT9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11898.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11898.t1"/>
        <property type="gene ID" value="Gr19_v10_g11898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11898.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26784" checksum="74E8DAF8BE697451" modified="2023-02-22" version="1">MSCLLFEVKLTRPIVIRYSILNFCRHSPPRMSSSGHAQTSNSSAIRALQMELRSLQSQPVEVGIFGPPGTLYQGGYFKAHLKFPTNYPYSPPTMRFIHSVWHPNVYENGDTCISILHPPVDDPHMISLLNEPNTSSPANVDASVMYRKYKDYGDQEYATVIRKQVDKSKEEARKDNVVVPETIDEYVVKAKPKLGNESNDVIDLDEDYYDYEDDDTDEDGNYGGDDEEDSGQGDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWY2</accession>
    <name>A0A914GWY2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWY2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11515.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11515.t1"/>
        <property type="gene ID" value="Gr19_v10_g11515"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g12747.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12747.t1"/>
        <property type="gene ID" value="Gr19_v10_g12747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11515.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12747.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32925" checksum="155E639E8022337C" modified="2023-02-22" version="1">MSDNPKKVEKQTQEIDRFDLLVDAHFKLKEWSLGQVEIHRGTGGIGTEIVTRLGNGAVEHRLAIPQEPFPDYVIGFQSLRINYVDRSVIEFLQNNRRLFESKETNLFIGTFINQNRRWEIIWHRIWPLINGNICVFYLSSSELGCLRRFSPTILRDYAKLRLINSFDCLFPKFPADDSAGASSAQAVAKWLLTPRGDGLPKVLKCDFCSERMEGLKMEFVNSTDAGEEWLLVRCPIERDEDKWAKWEKEAVRWEWRHQWNRIIIDFDDRAIGDGMLDANGGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXG8</accession>
    <name>A0A914GXG8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXG8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12065.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12065.t1"/>
        <property type="gene ID" value="Gr19_v10_g12065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037846653" evidence="2">
        <location>
            <begin position="24"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12065.t1"/>
        </source>
    </evidence>
    <sequence length="732" mass="82050" checksum="DB4A7625883D7B6E" modified="2023-02-22" version="1">MKVSNLFFHSLILLPIIIPSVFTEDAQNGSTFGLVSNQSSSDALALNEAAAILLKVDSENGIIAGGDANNSTNPGGMAIKIADVLVSSIKAIIRFFADICSKRRQRMEQQQPTPDLGRSTGRRAKADGRDGGWPWRGVEKGGDALCRNAFFSSRKYSNKLRHIFFSFSIINDFLINRCGAPFVWAISSSGLSRCIPTAGGTPQQCAHCQQSIDFRGTPPMAFAQKGNVVMNGMSSSNRGSTASSTPPFCASFARSPTTGRRHNEGGEQRVTGIRALRRSRIFPTMEKRTVGAAALPKWEASAEWEDTGKSTAYRQTSSTTRKLFPPASAEHLPKNIQLHQQTNSWGDDRTVPKAVGRASRGGGDDQNGGSRAYFQRLVSRFDAALNLFTDEKSCCENVYGCARNMDLFQKAKEFLCISEQRIWRNRTQPNGRPLDRCHLRYEGGNGRSAAAAADRGLDVIRRLRELTVAMEEQNRRENGKKGEGGGHSTNVWRTKRRISLLGMRLNGRECEQRAEQVLDTLLVCSGQISNILERRPAFPSQFLGATAHVQFGLFDAMDEITRQLLDRQREKRLRVWLTVSRCFGELLRMGSVSWKSNEFPWKRFTLIAHLARFLHRFADVCDTSTQMLCIIEVEKARAFVAEEVGMNSAEWRATAREQLSRIELDLAECQRVQKWNELKLDTQIVRRRDNRTEQMGPSRKRNSAKLREWLQRMLLGGRKITNKMMGKGLQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXK1</accession>
    <name>A0A914GXK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12086.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12086.t1"/>
        <property type="gene ID" value="Gr19_v10_g12086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12086.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10414" checksum="0BADE95394A67EFF" modified="2023-02-22" version="1">MDADSGLIIDDLDQEENSENVDPDEEVAEQVQFEKGTTTHGALALWFRGHRYVRRRTNCAWFRCEKRFCPAGAKLVDEEAMRNLHICQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY41</accession>
    <name>A0A914GY41_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY41"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12275.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12275.t1"/>
        <property type="gene ID" value="Gr19_v10_g12275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12275.t1"/>
        </source>
    </evidence>
    <sequence length="490" mass="55980" checksum="01FE3DE522E3D7ED" modified="2023-02-22" version="1">MHLLPGGGGGPLRFVHTCNGTGLASSRAMIALLETHQTGRQKGVKLPEVISRRMPTERMPGIRCTLLKGDSKYDFDEDDEKKRRERMGVRSSKLRQFYRKALHNKKALKSWRGSANDATVKLLAAGAEEEMTLLELFDEADDGDAVDEPPLRSADSATERRRWLDELDAMQRPIDTLAGALREQLAALETEHRQKLQHCAVGWQNALNSSSFCGISGRKRRKLESLTEECRLRSTLLAEKIRNCSDYLHSFDTLIRSIQREQKRKSEEDDFLREFLLKSARHQHKKGQIGQALDTFCQLLLATGGHLSAAEMEVLADVYREKVRQTREFHERISQAVRQVQLNESNSGRQNVVIQELWGQVLDDLRSECAESFEIVMQVKCDEDNTVGRSEPNCAQKHNTEQLKLLMASTVCALWLHITPREHEEFDDIKDLFFSTLDDYIETFRIDNQKNCVKNVADDLEKTVRELMGNYPTVAGTKKMRKIAQRILII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYC7</accession>
    <name>A0A914GYC7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYC7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11916.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11916.t1"/>
        <property type="gene ID" value="Gr19_v10_g11916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037295785" evidence="2">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11916.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13271" checksum="59764D6F6548ABDD" modified="2023-02-22" version="1">MKNISILIVLLTNLFILLLLQSADAHPYPPPWAGPSPYRQWGPPPRPWGGGGGWGGGGGGRRWHHGRRRESESSERGGHGGGRGRNRSGSSEEKRRSKQPQQNAQTGSVAVAIAVAGGSSTTGTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYY6</accession>
    <name>A0A914GYY6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYY6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11690.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11690.t1"/>
        <property type="gene ID" value="Gr19_v10_g11690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="484"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11690.t1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59785" checksum="06AE9D75D868C389" modified="2023-02-22" version="1">MASPSTGSATSAAAATTANSDDSVPISTDQLILRTRPLPSHSTTERFVNSVQFPISDRLLIEAVYDRRTEKPRAEVLKEHFIKEGRIDEDAALRIINECTALFRQEKTMLDIEAPVTVCGDIHGQFYDLMKLFEVGGSPSTTKYLFLGDYVDRGYFSIECVLYLWALKICHPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMESFDALPLAALMNQQFLCVHGGLSPEIQTLDDIKKLDRFKEPPAFGPMCDLLWSDPLEDFGNERNSESFSHNTVRGCSYFYSYAACCDFLQHNNLLSIIRAHEAQDAGYRIAPNYLDVYNNKAAILKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVHILNICSDDELMAEGDDTFEGGMPSTRKEVIRHKIRAIGKMARTFSVLREESETVLQLKGLTPTGSLPLGTLQEGRKGLHDALKGGSNDPIKSFAEAKALDKINEQRPPAMSHPASSQGSSRDVSPQQRRAAAAAGGGEGIRTRHRQQTDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0E6</accession>
    <name>A0A914H0E6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Exocyst complex component Sec6</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g1279.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1279.t1"/>
        <property type="gene ID" value="Gr19_v10_g1279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF51">
        <property type="entry name" value="LYSOSOME MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1434"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="10">
        <location>
            <begin position="204"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="11">
        <location>
            <begin position="446"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="12">
        <location>
            <begin position="628"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="812"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1279.t1"/>
        </source>
    </evidence>
    <sequence length="1487" mass="166592" checksum="24224886D98A4451" modified="2023-02-22" version="1">MEMDTEIADLEQEISKSINEIAKNLELKYRDFVPSYICLADCQEKIQSALQNGKESVLKLEVQLANAEKEIVKLKGGAPHKELEVVQDFVDRLDILNEMERCLNTLWLMPADSKMEFDPLANTRTILRLEELCVTLESESSNYLESINERILPLLFTEIQTRKGELGQQLSEFYASFVRFNEDDRVSPPLYLMNITCPSIKIASDCFSAMRQLGLLDERVEEMVDIVWEHFCLKLIYGVAVPDSSQLQQDDGGVRIGIVKEVEMSKKPDPAAVFSALSQFFGSLYTALKGIRADNRSLVDLFGEAISGQLIGALEKGCLGPAIPFEKHEASHVYEQLTKLSRGFLEFMQDKGFFARPVDHLFGNFFDSFERISVDRRCHHFITTARELIKQPYIELVAVGSALDTKEEKSADILHKMEEKLRIKVDDEDANLPTSTKWDKYYTKIFQFQRCQISKSTFKLVNVLHDVLRTAAETDSEMEASRLVTTARNILEMFVNTAPEYHRLTLSSVPHMAAVFFNNCHYILHRLTTMSSDVLQNILQVSKITGQDCAFTDMFTQLRTLAATTLEQHIVQARRQLSATIGEGDLFVGLLDDKSHKRCVKVLNGCVMQLEQTASVWREVLSSFVLTHCEDIASSDAETSADLLTTLSDRCQQLMEIDEQPTIQRVCEEPYHKLQQIIFCLKANLAEIGHQWCEGTGPLALWLKPAQVKHLARRPIRRHQSLPSSSSLSSLDCVMNEYIKGATERMIHPSLLELHNTFDFKVPGAKRICAYCAVVCAAGCACLTNTNPDDVKNNHDWSAAFGRGVRYGPKFGHRRHGNGMGGRLETIHERPIRGGGATRAQNGDGRRRGPIRRNEFQQEPPVEGNGERHAPVRGKRGQRGVRNGRWTNHRRRGSAGAGVGVGVDHGVNGSTDFGQDGSGHQPVEDTRGANGDGNSESDIGTRQGFQLERECRPNSAVINYRSRGGAVKCYRNRGNAVELPMGFCCCVKCCFVGALAVVGIIFLFLGIGALLFVPKFIGNAIRENDFVGRDQNGSDNLALERYRNPRYDIKMQIWVISVQNPSGVVNDGERANVTELGPFTYDIRLHKENVTFAHNDSRLFYRNVKTFFFNRNLSCSECELSSSVTVPNILFQKIVDVFEQNPGLSPFIGPFLRSMENVFVTISVDELLFKGYEDKLIGQICANPLTKGICERHNVPDRIGLFYGQNETDDGLFEVDTGKEDTDRIGSVYSWDGMGPELDETHWFGDRARLIRGTDGQLFPPDLRDVQKLQIFSGSLCRSFDLEFAHSLTFSDLSVRRFVLPISLLSSENQRAQGFCNPNSAEYFHNSSPRIFLSAAHFRGAADEVQQSIDGFDVQPAEDDAMGFFDIEPLTGAAVRIQQRFQLSLGMLRGNLRMTRNMRNFIMPMIWMNQSAVVDSATKQQLLLPLTVLRTSRIGGIVLISLGTILAIVSLGLTTFFFVKNRKNAASNGFGAEDAAAASGCISAKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0X6</accession>
    <name>A0A914H0X6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0X6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12923.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12923.t2"/>
        <property type="gene ID" value="Gr19_v10_g12923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12923.t2"/>
        </source>
    </evidence>
    <sequence length="230" mass="25347" checksum="59AC7A08F105DF9F" modified="2023-02-22" version="1">MLGGSNGIARRVHLGFDGNESTFLAYIRRRAVHTEHAHSSQQQNLLNSSRPTRPRHKMLFSKPCSISASHPLMVLLPMLFIVVAMLSSNSVSATGMPPKMECCQPAMMSCCAAPAMQSCGCGRRKKREAVQPHIKGNETPCPQTEWRQLMQNAIVPLDDIESVNSVQKALMRRFPDNKFLVMCALAGDEIRRPADSKQMLPNEVHLSSSGNGYCNVVSERIWCQAAAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H169</accession>
    <name>A0A914H169_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H169"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12692.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12692.t1"/>
        <property type="gene ID" value="Gr19_v10_g12692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12692.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31779" checksum="54E2413B47AE7C0F" modified="2023-02-22" version="1">MTPFKHWPIESQCKSDIHKGTHLYIGTSAFESRSWKIICENIWPFFSDNICGISLSSSALDRLRQFSPAILSDCPKLRMIQAYGLFPEFPADDSAGASSEQALAKWLHTPREDGHPKVADCFCDSERMEALKMRNTQILTVSFERKNNFTGERLEMRCIERDFEEDEWLLVRCPIDRNEDKWSKWEAEAKYCLGNSVLIDFGDKDIGDGGSRPNWGPDNWTVDNPTVDNPTVDNPTVKTIRQKWTIRQLDNPTVNENFKKQNCCSKEKNRAYLNGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1E5</accession>
    <name>A0A914H1E5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1E5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13258.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13258.t1"/>
        <property type="gene ID" value="Gr19_v10_g13258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031720">
        <property type="entry name" value="DUF4728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15860">
        <property type="entry name" value="DUF4728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13258.t1"/>
        </source>
    </evidence>
    <sequence length="575" mass="66769" checksum="529A74E70A593C43" modified="2023-02-22" version="1">MSCNPCCCLKLKDAAVTIGIWSTIYSLVQIAVFVWQFSVLAQCQHVVMAQSNLQCEYYCPCVGASTARTSAIIEGLFVIQILCLIVAFFLLFASIMMIYGVHTWSRYLLVPWMVTMCASILTSFAYCVMWWAGDVRDYWLMLTIVEMFGVFLNTYCFVVIIMFHRRMLVELEYYARRRKYDRFNQLPRGTPQHTIEQELDETDEEPPRRKEVFAYKRPLDSQFPPKSSPPQPVIGSQLTGDFSGGMGPQQRERAREFQTARQRTPMERFQQETNQSASAQWNNGHKNRNLTNIEKFRDEPNGGQLLTDKKVRAKCAVVNTFNTAAIVATHWSTAIVTDFPVEDTENERKPSRRRRRSGRKRDRRGPWEQNWSDRESDLSEFGHTVQSEREYGNVLSSERQQRQLRRRFPSMEGRNQQQKGRRSRTLFQANERELNRMGSTCTLPRSSQQFLTPYRGISIPQHIVIPPVAARTCETLDPRPERKYRINSEITVSYDPKERQRHNEWAPSRKKPPNIPPRTPHQGLFPHPAGYINLNTNSVHVPTERREPIQQQQEVQPLPDQSPRPGQLISMNSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1P7</accession>
    <name>A0A914H1P7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1P7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1285.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1285.t1"/>
        <property type="gene ID" value="Gr19_v10_g1285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1285.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14703" checksum="B9D66A011D6B7D39" modified="2023-02-22" version="1">MFIVGCSQCRRWFHGKCVRISQRESKRIPFWQCADCKELQNTEEGDEQGEIQLMFCVCRRPYDKERFYVGCDGCGDWYHPECVNTTEEKINALSGECYLCPDCEKRPQKWFDAKMMVTTKTESNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H223</accession>
    <name>A0A914H223_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H223"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13278.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13278.t1"/>
        <property type="gene ID" value="Gr19_v10_g13278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13278.t1"/>
        </source>
    </evidence>
    <sequence length="669" mass="76472" checksum="758564D4C05CB7EF" modified="2023-02-22" version="1">MLKHGGKQLRASFRIQRKQNTLECDCVGGTDCQKGCTKQSYNHYKSPYSVFTEPKISRPTRSCPAGPTNNQEKQQFNKFSTPLEIQATIHERSGSYENFSTAQLEQLCEDKQRESGKGSESWKKAVGQDPAERPQKQTQRQQTEQKRRRDMTLTEEIGKRMKRCQNRCGRHSITQYCHQQQPLSTSEYWSADPSPISENQPYFHHFRISPRVPPDVGEDEESSSVDGDNSSDDQEISPTALIQAWECQVRILTQELRACKGVAEKYRSKYLRLKARTEELNSELTREKERNSWLLNQLIATNDMMTQLSWAHLHFRDIQKHNFLKGADVADNEMRPPPNYPFGALLEDFEQPDKCERNARHRSAAGEVQAELSSDEFDDRATAIRKGLWAVEPTSLGGVGQRVESENGQQTINSKCKQQSPLRTPTPILVESANEHIRNQLHVEVARGSHLNSSRNSNSRLISPPFRTGMKKMVNNNSSEMIEEDNDEQLEEDEEDSENFIGTDPEEQDQQLVVIPLDAFCQQQQLGEEKGGRRAKGKRETRKLRGDQTLSVKLLLRHSRSSEDLRSTGKEFFGNGKRMVGSTMPSSSEDDIRMWKKQLRSRGERVLFRPSRKSLLSGAIGDGKGPRIFRRFGQREREALAKFDYLLDERTDLSGLMSSPEKLAETKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3E0</accession>
    <name>A0A914H3E0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3E0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13277.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13277.t1"/>
        <property type="gene ID" value="Gr19_v10_g13277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF37">
        <property type="entry name" value="HOMEOBOX PROTEIN SLOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13277.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29869" checksum="AF9EFDF7556B259C" modified="2023-02-22" version="1">MATNFSIESLLVANEDEELQNDDKMAEHQHKAQHLFCPTSKARRGRTAFTFTQLIALESRFKQNRYLKVGERTKLAQMLGLNETQIKIWFQNRRTKWKREGSETEGTENKGQAMEKALRGQSRPPTVAALRRFVGPGKQCRLNSAERPCRSVKTTLLPPYPPPYANECPPIPLLFQQPMDSQLMRKAISFCSSDMTFHPQNVPTFRLWRSNSSWHQQFLRHFSGLFLQQQNCPTRLTNKMLLNIDDQLTLRTFVNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4Y3</accession>
    <name>A0A914H4Y3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4Y3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14201.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14201.t1"/>
        <property type="gene ID" value="Gr19_v10_g14201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000007">
        <property type="entry name" value="Rab GTPase-activating protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="539"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="957"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="809"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1090"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14201.t1"/>
        </source>
    </evidence>
    <sequence length="1121" mass="127709" checksum="D89527A05323C429" modified="2023-02-22" version="1">MAIAPERRRRRDSSPIRSAINTFLADPSRRSLNSMLSSSPQPTTPRPISQSNEQLCDNGTARPLNLSNSNKKLDGTETIIERLSYLGCSKMDDPTSESEMLGIVSTMNAEKAHDAVSVTLVIPNGPTGIVRLLESGKQCPAEICSFPIQRIRFCARGRPETSERGCFALSFTQLAGKNATLHQCHVFRCQLPEETVRALFCFAQAFNRQQSGSIASKPPSPSTPIQFRLPPSTAEECDTAEELFEFETLIEIKERDARKDQEHGFSVCPMERNCFKMRRDREKRVVIMLRQTAGPRHLRVKKCFGLLLAAGRNLRQSDMHLLELKNAGEGQQNPYVFIAEACWNPCNQNFEVLNTETPRDTRVFMTIAIDVILDTLSESIRFNVECKARIFQQFERFWSAPHRALSERYTLLVQKMHMDEQASTSSADSGIFVQQNQQIQSGMAPDKNACKVLRFESATERERLMNREKSPSSRVMPTQLIHPADDDESDSDEPLLSGSGEVSRECSKDRLAEWRQLVDQWKKEPDKRPPGLNALIYDGCPDVLRGEVWPLLARVDSDSSDLIQTYQMNLEKECPQDAVILRDIHRTFPAHEYYKESNELGQKSLYRISKAYSLYDEEVGYCQGLSFLAASLLLHMPEEHAFCVLVRIMFDYGLRELFKTGFDALHLRFHQLQRLVEDYVHELFSHFYQTGVETHMYASQWFLTLFTAKFPLQMVFFIVDLFLTEGINTIFHISLALLQDSKKELLQSDFEGVLKFFRVNLPRKYRTEANAKDLIHSAVMLKISHKRLAKYEKEWHEMKRREIESQDPLERLERENCRLKEQIMRLERENDDLAHELVTSKIELRHKLDTTEDQLETAVSQMAKKNRECEEVAERERQLREQSEQVKQRCRQEVARLEEELQRAQGVNAEYKRICTELGLTVDEQKRKLNEQRKSVKIRTASCECCAEALNELWADSPAPSSSSSTNGGAGGASPLPTRRPASAMANNGRGGSEHSGTNSPIQNGSRSSALHVMELVERLEEKEQHIRQVELELAQTKLALVESQCQNQDLTHQMSTSMHHQLQNNGVDHSATDTRPAWLKKTLSSIKEAQSALSSSASSHQRTASNASVASTYTDHPPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H559</accession>
    <name>A0A914H559_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phlebovirus glycoprotein G2 fusion domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H559"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1409.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1409.t1"/>
        <property type="gene ID" value="Gr19_v10_g1409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043603">
        <property type="entry name" value="Phlebo_G2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009878">
        <property type="entry name" value="Phlebovirus_G2_fusion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19019">
        <property type="entry name" value="Phlebo_G2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07245">
        <property type="entry name" value="Phlebovirus_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037249978" evidence="3">
        <location>
            <begin position="17"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Phlebovirus glycoprotein G2 fusion" evidence="4">
        <location>
            <begin position="18"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Phlebovirus glycoprotein G2 C-terminal" evidence="5">
        <location>
            <begin position="350"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1409.t1"/>
        </source>
    </evidence>
    <sequence length="663" mass="74053" checksum="84BB6F8DC2FB95ED" modified="2023-02-22" version="1">MINLVIVMALLPRAEASQTISVMTSSETCRRGPTGIHCTVSKATTLTLLPAGQSTTLMVRDEHGVVLGTLNLVLNALTMECVTKSEGWYRSYAVESKSNFRCPRAANSSCFGNTCGVVRPEDKLWELKDVNDWPGHAHCLDSLGSWAKGCALWPSNGCLFYRTYARPTGQAIFEKIGCPTWKLKIATKMKLEMNSDSESNQETEAILYPGMHFHWHNITLTPLAISLPPAPILSSKFITSEDAVALVEQLGDDLHCPDEASARDFNCTLAPTACSGCSADHETGVVGCSCRDLNLEERIEDPQQRLPLTIGQFHLRNEESRIWADTGYSPVQLHVEMKDVEMILQLRDSKCWIEALNISGCYRCQTGAQLWYQCRTDWGRALAKVECSDGTIFAASCSTNQSAQREVLNFDQSLISTLCSVDCPAGITDFVLEGELYYVPIKHRSNFRHRQSERLDSGEGNWFDLNFDPWALSRLFFNPWSLLVFAVVLVVGIVALALFLRFNPPFALFRMVAGALAAQDANAVPGKLLLAICLLLAASAVAPGEDLADIGSSTVILNYSPAEFWRDRPQFGTVIKFGNPFSQTRADDQRPLTTEKRRIVSRRDDRPSTSDDERERTDGHPANQRRDDRRTNKTGRDERRKDEGKRDDRRLRRSKPEENAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5S7</accession>
    <name>A0A914H5S7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5S7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13938.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13938.t1"/>
        <property type="gene ID" value="Gr19_v10_g13938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13938.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26393" checksum="AF4266B29A5A3C77" modified="2023-02-22" version="1">MDANVGQTAQQKAAAARLWMTPTSEEDLPTIKAIPSGTKVFFRWANRTAYINVWGSSEARQKLMKQLLNSERLSKDEVQSFPNSSTETAPPFDAQFAAGDLFEPPFHSNVDRLSSSVIVLLSLVGLVFVLLLCYFLVRLLHGGEDDDNSLRRQEEGSPRLRELQVVLVPKKSCTSLPSALVHPFGFGDKKHSVERIAGLGHQPTNAARPFPRRIYELQAEEGYFSCPPSMRASFELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H670</accession>
    <name>A0A914H670_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H670"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14369.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14369.t1"/>
        <property type="gene ID" value="Gr19_v10_g14369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14369.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36819" checksum="AB3D02F1812F1EF5" modified="2023-02-22" version="1">MSQPTHPIEQLLLHFHKVPVIVTFIGYLYTAAHHRYLPSNSSGKESTIHRPNVRRQQQRQINFIRLGNHRDTEKQPSYGGSEAINIEINETTRTRDQPNIWRAHDHQLHRTDGHSSNRNGYNKWAAARSPNQSATLEYVYTRDMAPNADKALAKFNSAITAHGKAVANVHLETRNPTTANHSKEKGAANNATERRNPSAHRIYSGQPTTISRQTRERHPATTRIDKRHTASQQITLLSKIGIRRGQQRQNIRNEQKSKAAMHFEESATSKRQTRRASRPMEQERRKNEDEPDAQDGPSFSFRAGVSEFEDSGRSKFDRLMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6L4</accession>
    <name>A0A914H6L4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6L4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14660.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14660.t2"/>
        <property type="gene ID" value="Gr19_v10_g14660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037713206" evidence="2">
        <location>
            <begin position="24"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14660.t2"/>
        </source>
    </evidence>
    <sequence length="737" mass="81832" checksum="593E34BCACA05091" modified="2023-02-22" version="1">MCRQPWLSLLIGAVLSALFLVACEPVYGNMNAPHAAAHPQSAANNNNDNTAIANELIASMFLLGMLSSFSMLSALFTKPGSSIQMSGFYRVLLVIHCSVSTVQTAGLAFKDGFSFIAPEEVVFDSVCNYEYSDVKKAFDKTIPATSAALNIPKPKSSNVTVADSMCLLEHKCSWGKCWPMDGKPATSCCPEHYEFVCCKEVGEAEQTLLKQMEGCKETLNKHCPCGLYNCIHKKGAGRTACCAEHYEFSCCKKPPPPETPTALQLKQNETCAVVAKADCDCGWAKCIRDEGYSATACCAANYKFTCCVTPPTTILPPVLMEQMEQCNKTRAACPCGWGNCIPTVGTGSTPCCASHYEFVCCTEPMVRQWQEIDECVRVRNKCNTRCLPKRGHAANACCSANYKYTCLQPEFVQRDTSSTLEELLTDFQKRKECNGNNSECNCCWRKGSTAAQTKPIQNCRAAHEKAQCYCALIPVSKPDYDPANHFCIKDKTQMASAYCEEGYRFLKPCLNPNPAFIYTNSHLYTEWSEECNAMIKKHCKCPNNFTVHVCELDGTKNLTSRFPAGSIDNVCCYAPYSFKCCPSGPRLLPAGIKDFPADHRFKIERLQPNTRKTDFAWEKPVSEHCKQKVENCSCGHASCLFTGAQKHDIIDICCEEQYEFKCCPDLDDQLRILKNLWTGMSSTEYVYVRDGTCTNKTAIKRICKTCDRIFCFPREGVPASVCCPENYESTCCMPGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7H6</accession>
    <name>A0A914H7H6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7H6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14539.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14539.t1"/>
        <property type="gene ID" value="Gr19_v10_g14539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14539.t1"/>
        </source>
    </evidence>
    <sequence length="610" mass="69461" checksum="908610E6447E6C0B" modified="2023-02-22" version="1">MFRCVLFAVGKKKKCFGASIVTPHHYKQQQHQLLLLLVLVLVLLIFHPTDVFLLMLFEAGGLELSLNAAAAAQFFFPIHISPPAVSGPSTPRPHRSTGENGWTGGVKFKFFTFQPSRASSPPPPSSSSSSHLFLLLLLLLLLLPSGRLFKRFHLTKDKNDEVPNLFAVHQCHQRPKLGEAQPEWVEPPRHRHRLAVEKPRLPLPHQAERRQRLHLKQLQRPRPKQLRLHPQSNLQLNSPHLHLQLSPLSSKRPATDGSATRTDTEMKRVPRQEVAEVEPPRHRHRLAVEKPRLPLPHQAERRQRLHPKQLQRPRPKQLRLHPQSNLQLNSPPLRLQLSPPSSKRPATDGSATKTATEMKRQQREAPAEVEPQRHQLPVEQKPRLLLPHQAERRQRLHPKQLRRPRPKQLRLHPRSNLQLNSPPLRLQLNQRSSKRSDQRFFHPYALPCLPSLSFGWTFCWERVTRRHRLQLHSVADQNSMTTVFRSSALPYSILVILATIELCHGLEKSKAVGPCLKGGQCPPAHFCAGDNECYPKKAAGKKFARRDVPQKDNIGPCVNGLCPKGYECRDDACFKVKVPPGAPKSLGPCVNNKCPDGYSCDQSEYKCFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H888</accession>
    <name>A0A914H888_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H888"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14723.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14723.t1"/>
        <property type="gene ID" value="Gr19_v10_g14723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000079">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF6">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14723.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23792" checksum="D43E3327E7500688" modified="2023-02-22" version="1">MGTTGSKIGELHLWKGRAPFSPQQLDEYQDCTFFTRKDILRLYKRYHQLDPTLVPTSMHGGQAQTVKLSLELISQMPELRENPFRERICQVFSDDRQGNLSFDDFLDMFSVFSEMAPLQLKLKYAFQIYDFDEDGFLGRDDLRAMIVAITKKEMNHERDELEFIVDRVIEEADLDGDNKISQAEFEHVVSRSPDFIRTFHVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8L2</accession>
    <name>A0A914H8L2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8L2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14243.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14243.t1"/>
        <property type="gene ID" value="Gr19_v10_g14243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14243.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14609" checksum="4D8BBC1CB46D18F4" modified="2023-02-22" version="1">MSATEQQQQSQKRARPAEENGDEGAVLTKAQKVDNGDVPTVTANNEANSNSNKLKAKLTNNEKAKADEETEEQAHEEEDDSEGESGAGGDEDEQDDDEEDDEEGVEGDDDDEEGDDDDEDAEADEGDEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8P3</accession>
    <name>A0A914H8P3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8P3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15074.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15074.t1"/>
        <property type="gene ID" value="Gr19_v10_g15074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15074.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19120" checksum="5C7BC948EB6DF643" modified="2023-02-22" version="1">MSITKSTDRTPKLDKLNPIQLISLDKLNPIQLINLDNLNPIQLISLDKLNPIQLIKLLNMSENELGLCFKTISNWKRELGQTKPQHIYSDSEQKELMKRYYEIKDQNTKMSVGDIAKNLKICRATLYIWKKLFDRQQMHPSSVDGHSVEENAVANVQKIGNSNSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAC0</accession>
    <name>A0A914HAC0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAC0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15244.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15244.t1"/>
        <property type="gene ID" value="Gr19_v10_g15244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15244.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36728" checksum="8B1FFA6E795DB5F6" modified="2023-02-22" version="1">MANKNLLRKRRAEMGAQKRWEKRIEKRASVAKATQARWAKKVDFSTVSGLFDSAGQFDSGGRFDSGFFDRSDNKESDAEPPTESQHTECVQQVNELSRQFEEKEKLLAQSDVNARSMEMTIEELKGRNAALEMELQRCKEEAEQFRKAVKDRQKAEQHRRIEIETELTNLESEILQTQMNCLKKRLQLQSNPERAFLNSRRDRSAGSSLLRVEQRLEMLGAYKSRWFQQYNENEIRNALRGTGPEHITTKRLIVDLFGTVSFWGVNLARLELFSIITITNKVLPNGTRKTAGLFVAFAANLFPCLSLYEPGSKNLVFIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCZ8</accession>
    <name>A0A914HCZ8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16218.t3">
        <property type="protein sequence ID" value="Gr19_v10_g16218.t3"/>
        <property type="gene ID" value="Gr19_v10_g16218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000139">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1079"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1117"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1143"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1202"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1403"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1466"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1235"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1310"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1560"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1705"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16218.t3"/>
        </source>
    </evidence>
    <sequence length="1764" mass="196844" checksum="818561BDE093AC78" modified="2023-02-22" version="1">MEVPEPLCFRPRPSLSSATSCSSDGFSTFDEGSLPGGPSPSQLQRVHAMQLGVHAQAAARVQGRVPEDPAPAGTLQRGWDTFRLLPPKPDRRGRGALYASLLQLMKLFTFVALFFLTLATSILAKSVVLLMANGLGQAGRNVSICPDKIPEAATNHVLISTRHAAKWAWALLLLLCVPEACTFVRALRRTLFRRVRAPEITQFVLVFVVETVHAFGLGALCFALAPHMNIIALLQLGSALCLIPAGLQPTTGAVLWAYTSQPVGKSQYAQHAFYSMPGLAFACAVCISSAWWQNFVHPHSFLAPIRLLSVIAARLRECRSKTYVLVSPWKCAVLTLCMLQFVPPHVPLHALLQRDPFSEQLITINADRLNESQIRAFQERMQDYERGADYHISTASFPSMAQPRQASVVEQISDGEAMLMNRTRPTKLQVGTSKSKQPMVTGTKSATHRKMGKRALREDEQEEEQGAKEEEESISAYNIYDDRVELNQFTTPYDALWLTLFQVACAMICHFSAKFACKITLTKTGLFHVVMQRVGMALPVLLSGPLSVLLLAHACESHAHDACYLSNWLSKELFWKCPEQPFQWQFWTDVRTLLWLSWWLAQCWVCFHLWSPSQERLARSERLFVLGQFDALFPAESIGLDRRRDDKLRIRSEELDTDDGTDDGASSVRTYESTAISDYITGDALMEGGGGVLPSGKPPSLYSSSQLTSGSGRLDCGGLIRDQQSAADAICKIYVCATMWHESALEMTCMLKSIMRLDEDQSARRNAQRYLKVVDPDYYEFEAHIFFDDAFELNDESGGTSTPRPNKFVRQLIGCMDEAASAVHRCRVHLRTPRKCVTPYGGRVSYILPGKNRLTVHLKNKWLIRQRKRWSQVMYLYYLLGYRLALRVHDHRRRELLSENTFILTLDGDVDFQPECVHLLVDLMRKNRRLGAACGRIHPRGSGLMVWYQKFEYAIGHWLQKSTEHMIGCVLCSPGCFSLFRSSALMDDNVARKYATRSEKPVHYIQYDQGEDRWLCTLLLQRGYRVEYCAASDALTFAPEDFTEFFNQRRRWVPSTMANIIDLLRDYRNVVKVNESISIWYIAYQLMMLFSSLLGPGTIFLMVVGAISISFNIDTRLALLGVTTPVVCFCICCLTCSTEKQLLMAQIIGALFAMLMTAVAVGTSLQIQKDGILSPHSIFLFTVLGSWFIAALLHPLEFDCVIPFALYFLAIPSMYMLLPIYSLCNLNTASWGTRENPASTTSAAADHGRHGTHNGAEDGEVSLGCGNLCRVVYNLGGNASAASSSSSSATTVRRLDEGLRQIERKLENLERLRRDGTGARRAQRQQSGDEAAVHQRVAQRMDSSNWMEDDLFKHFETIYLDPDEEAFWREMIDKYLKPINMDPQEVERMQHGLDELRNKTCSAFFMVNLAFIIVVLVLQMQKNFLHIDWPLGPKVNLTMSTALGAGSGPYEEDECVISHLQLEPMGFVFIVFFLAILVIQFLAMLFHRFGTLAHIIASTELWCCSRRPIDAISEEELMAQNAVEIARELQAIRGLNGLMDSSDSVGNLQHQRRPFPAQQAINGLSSDSPPPPPPPQRSGRVRDTAAVAAPSTNFVDGGRKSAASGAGGERRMDTLDAAFRRRFFALTADGSDGAVAERLATTSGGAAKVSSSATGGKRSQIQSSMTLNRRTLRALERRRESIYGGGAGTVGTGLKRLSAPSNRFECLSSDSDEEADGREAAPPAPRSSAVPIATALRCHRLDELFRKEQSAAGRHGRIRKESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEE2</accession>
    <name>A0A914HEE2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="5">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914HEE2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15854.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15854.t1"/>
        <property type="gene ID" value="Gr19_v10_g15854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Hemimethylated DNA-binding" evidence="6">
        <location>
            <begin position="282"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15854.t1"/>
        </source>
    </evidence>
    <sequence length="566" mass="64372" checksum="2D16318E28D0F8D2" modified="2023-02-22" version="1">MSKLLERNVFLQKSAGKCFSQLFGTEHRRKVATHFGFAKVDEVDKKERVRTVFANVATKYDLMNDAMSLGIHRLWKDYFVQRLNLSKDSKVLDMAGGTGDVAFRILNRMRRHPMGAYAVTVADINENMLEIGSIRASTALPSSDLARLSWVRSDAENLTFEDNSYDLYTISFGIRNCTHIEKVLSEAYRVLKPNGVFACLEFGLVDNAMLRRIYDVYSFQFIPVLGQLLVGDFNSYKYLVETMLNGFTSRAFTTSNIRSLRFRSQRPQSELRAVGKLVTQSDAPYERGQCFIHKLFAYRGIIVRTKRCTVFTKRFSDMQTLQEAVPFYQVLIDKEDWSDMNFKADMTTYLKSTGNREETAISGMDIVSHDEILPFEPSASDLSLPAEGGGERAPIKHYLYDQLFKKKTDETKRGDSGAARSRPEDEMSWIFPIAVTKQTTESVEVQVSTFNLGTNTANRSHCPHNWRIVLRVESSQNSTMYLRNAVLKVSSMSGEKTVSDWQNLYLTPTKPALQLSTNISLPYPKGNNLWGKIHVQDEEGRKYELSVPAVLLENNSGISEHTEIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEK1</accession>
    <name>A0A914HEK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16279.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16279.t1"/>
        <property type="gene ID" value="Gr19_v10_g16279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16279.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="27520" checksum="E56D727B6C1C5A92" modified="2023-02-22" version="1">MAIALTINVLALSSREQLVQYDGLELELELGGGVGVGVGRWAVGLELELGLELGGGVGVGVGRWGWSWSWAVGLELELGLELELGGGVGVGVGRWAVGLELELGGGVGVGVGRGGWSWAVRVGVELGGRGWIWSWAVGWSWSWREFGVGVGAVSLELELGGLELELGVGLELELGVGVGRWVGVGVGRWVGVGLGGGLELELGGGLELELGGGLELELGVGLELELGGEFGVGVGRWAVSLELELGGGLELELGGGLELELGGEFGVGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEZ6</accession>
    <name>A0A914HEZ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15 16">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g16377.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16377.t1"/>
        <property type="gene ID" value="Gr19_v10_g16377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000023">
        <property type="entry name" value="Endoribonuclease dcr-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000005">
        <property type="entry name" value="Putative endoribonuclease dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048512">
        <property type="entry name" value="Dicer_platform"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20931">
        <property type="entry name" value="Dicer_platform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="336"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="23">
        <location>
            <begin position="544"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="20">
        <location>
            <begin position="823"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="19">
        <location>
            <begin position="1352"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="19">
        <location>
            <begin position="1610"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="18">
        <location>
            <begin position="1798"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1050"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1242"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16377.t1"/>
        </source>
    </evidence>
    <sequence length="1882" mass="214422" checksum="53BC5ECD93C18A88" modified="2023-02-22" version="1">MSWRPRDFNMRQILPSDYQVELVGRAICQNTIIPLSKNDSKIFVSIQLIKEYSYRLMRNHEKAVLLVNSVSLLEERATQIEFHSSLKVLRIGAGFSDNKSELIKESQVLVISPQIFLGLLNKKAVDLKMVALLILDDCHHCLIGSHPYCQIMKKYRTLSAKRPRILGLTPSLLNKRVSPSNIKGTAKRLERIMHSRLETASDLAIICKYVNKPKKFISLEKLRVFIEINTDFREEVTQVDPRKPILEAINRASATLRQVGSWCAMRGCLLWKKKLAKLAEEPFLGPKQRSALKTAEATFHLCSKMLGQKVGCVNSFAKLVGDSPQASFVSDRVRKLLEILIDYAPSKRTALSAKAPLSALVFVNERFIAFMINTLLKALVKWETEMFGHLKVDFLVDNNYPPCESGEEERKLANKKLEQTLQRFRNGQLNVLVTTNVLEEGVDIRNCNLVIRFDVPVDFRSFVLSSGRARRENGAFYIISEERNYASLVNELENYSKIEEFIMDHYSSNEILKEEEIPKNVDELFPPYAVESPSGRAQVTLSGAIPLINRYCSKLPSDVFTRLVPHYEFNSAQQRDGKHSHFAQLLLPINSPLKECIQLNECGGIAEIEALFASKSLALMSVALEACKKLHQTKELSDQLTPTGKEIVTNLLGELEDDEEYLPYLLNKSGPTKRRRLYDRKTSKSLVGTLPALDSICIVYVIEMRLVKPISEENNPKKRRIIDPHEIDWAFGFLSCKELPSIPAFPVYQRQGEMLVKIRKANAPLLLTQELFQLVSLFHQHIFEDILRIARGGLAYSPEYSPIPLPIVPLKRVGPTDDDYELDRSHLRCDIRDHPTMPPEECRRNFSFDESRYADAVVMPWYRSEEQSAFYYVAEICGDQNPASPFPDPKFSSFNEYFTAKYQLKIFNQEQCLLDVDHTSARMNLLLPRSGSGKVSKKPLDPSQRQILVPELVNIHPFSAALWSMIIALPTILYRTNSLLLADEFRVKIMEDALKMSECAKTPSAEWKWGPLCYNVPQANGCVGEAEQQKPHQQIIIKNLDQLKKINQEEEGLKKNGSGTATKERTGKHGESNLEEFEIGIWDPEDLVTPSVERIHSPQVVNSLSAENGHLSNGLRNGHRELSSTREEEISELIAIGSDYSIHSYGDLSDEDEVAAEYANCTFLMHNKVSDIDLGDIEHAGLRERGWGENDAEDFVTNNIQIENDFLPLTISRNNPDINIVTLMDDLQKNFSGDLGGVLSNCGESQQAKQNPRVHNKTEPSSHKQPKPVLLINELCLDPMHAMDELDKRLEEDVVGEEFFYWDDQDAVMKLEEFDRIDENTKRPDSPECVDFPSGNQHFEVTAPDISDWMQFSFMYNKLAEHPHGVSPVLLLQALTTSSASDGINLERLETIGDSFLKMAVTDYLYHTHPEQHEGKLSFARSKEVSNSRLFYLGRQRNIPVLMETAKFDPHVNWLPPCYASTSEFHAVNPLDQNDHEEEVGEIPQQSVIDEKKVELTGWGTLDDDRQHYKCENGVETITFPQEIKQKIELDLPPLPYNMLTQQWISDKSIADAVEALIGAHLIQLGQEAVLKFMNWLGVRVLTKRFCVQPQPLDTHSRKSLLLLYNKFDFSKVEDTIGYKFADKGFLIQAFTHASYFNNRVTGCYQRLEFLGDAILDYMITRFLFEHRKQYSPGVLTDLRSALVNNTIFASLAVKYNFHKHFIMLCPPLFQMIEKFVNFCKQKDFLHCANFDDEIFMITEDEIDEGHEEDVEVPKAMGDIFESLAGAVYLDCGMDLDIVWRVFYGLMRDVIEKCCVNPPQSPVRELFERKNCKAKFAKLERKLETGKVRVTVTVNENLHFTGMGRGYRIAKCTAAKRALQHLRKLDAAKSKKDAEKKAIGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFC2</accession>
    <name>A0A914HFC2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFC2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16849.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16849.t1"/>
        <property type="gene ID" value="Gr19_v10_g16849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="298"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16849.t1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57436" checksum="FA3376430DFC2B07" modified="2023-02-22" version="1">MEEYQKEQQLCIVDVQKTDTTLRGPQNRWNLTTSHRGLMLSQRVEITEKDNWGPYSVFAALPIPKKDSGIFYYEVTIFGAAFGNSPNHLHEERTPFGNDRFGVNNHLASVWRGEASALSSAGNSGKSPMDAIDRSFAQLPRITIKATTVLVKEHKTLQTKMEQYQKELQLKIDELTEKLKVSIGQFSLKHQEHEKLKLMEDKIDCDQKALLERLNGLERGQTANFEQQKSDQKALNAAIDQQFNGREKQLNNILEQLIKGQNKMFEKQKETDEMLKKQMEELGNSSKKELEAGMNQLKGEIIVKMEQYQKEQLQKTNEPLREPQNRWNFATSHEELTLSVGLILKKAKKDNWGPCSAFAALPIPKKNSGTFYYEVTIFGTAFDVCVGLAPQQMPNGEFVGRYEGTYAYDREGTIYGHVVEECSRYDGIFYIYGKPSFYVGDVIGCGVNLATRQIIYTKNGERLETTGLFVDSAAELSNLFPCVSLYRPETKIEANFGPNFKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG10</accession>
    <name>A0A914HG10_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG10"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17172.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17172.t1"/>
        <property type="gene ID" value="Gr19_v10_g17172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17172.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13919" checksum="FC9A340FC3A4EB48" modified="2023-02-22" version="1">MQKQPATGCLKETLSACRQFSTYHKAVEFCKEAKTSATGDIKQLSERMVASEKVIRETSDKSAKFTPAAIFHKADTDERLFMNAVEEIDKMLSLLDNAMKRNEAEQAKVEAAKATLLGLEAELNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGE8</accession>
    <name>A0A914HGE8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914HGE8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16383.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16383.t1"/>
        <property type="gene ID" value="Gr19_v10_g16383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000986">
        <property type="entry name" value="Protein tyrosine kinase 2aa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000044">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="198"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="314"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16383.t1"/>
        </source>
    </evidence>
    <sequence length="557" mass="61780" checksum="4AF081155892EB32" modified="2023-02-22" version="1">MGNCLGAHCGRKKGPLDLRDAISDQHQLHLQLQSQQPLSPLSCHPPPALLQKHMADSAVLAIANNSAPPTPSSPQIGPAGSTPILKSVRSNGGGSPCSTILSGTEGGPKSGGGSNGSGSPPGAGANAATGSGNNIFIALFDYNARTDDDLNFKRGEPLEILNDFQGDWWYANSLVSGKCGFIPSNYVARESSIDAQPWYFGKLRRIDAEKLLMLSVNEHGAFLVRDSESRHNEFSLSVRDGGVVKHYRIRQLDNGGFFIARRVSFGTLQELVQHYNKEADGLCVMLTKPAMKVETPMTSTFTHDDQWEIDRRSLRLVRQVGAGQFGEVWEARWNHSMPVAVKKLKPGSTACVADFLAEAQLMKRLRHPKLLQLYAVCTREEPFLIVTELMQENLLHFLQGHGRVCNIAQLVDISAQIASGMRYLEEKNFIIGTSPRNEYEARVGARFPIKWTAPEAANYNKFTVKSDVWSFGILLTELVTFGRIPYPGMTNAEVLQKVENCYRMPCPPGCPIVLYEIMLQCWHKDAEKRPTFETLQWKLEELFTSEGSEYKEAMMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGK5</accession>
    <name>A0A914HGK5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytoplasmic polyadenylation element-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with fbf-1.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGK5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17171.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17171.t1"/>
        <property type="gene ID" value="Gr19_v10_g17171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12724">
        <property type="entry name" value="RRM1_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000001">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF17">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="127"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17171.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33893" checksum="C8EF99C4BEC7D540" modified="2023-02-22" version="1">MLCKSEVFSRKVFIGGLPIDIKETELKQTFHKFGSLLVDWPNRSSDSHFVKKEHYGATSRVTGYAFLIFLEEASVQRLIAKCYSEGDRYYMLMSSQTVREKPVQVRPWRLTDMDHMPRPTAHLDPRRTIFIGGVPRPTKASELAFVLESVFGPVCYAGIDVDPEMKYPKGAARVTFNTFKSYAAAMAGRFVQIPHSDNTKRVEIKPYVVNDQMCDNCQGKLCQDRYAPYFCGDVTCLQYYCEICWDRLHYGSGNRAREAHKPFVRMGEQTKQLFRLPHHHHANSNPVANNPPHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHA9</accession>
    <name>A0A914HHA9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">F-box protein 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHA9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17501.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17501.t1"/>
        <property type="gene ID" value="Gr19_v10_g17501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19676">
        <property type="entry name" value="UBR-box_UBR6_FBXO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000005">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000006">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047504">
        <property type="entry name" value="FBXO11_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF20">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="822"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="822"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="904"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17501.t1"/>
        </source>
    </evidence>
    <sequence length="937" mass="103447" checksum="4338AF1B03F5FD94" modified="2023-02-22" version="1">MAAAVVDEEGSTESIALADSQLLQTIGTNPRQTQLSAEIADAQLISAPFLEESSSSSHCQDVFQADQMDKRLAVRRRHSLQHQSEDASCRSSLAATADEASEPPSKFMKPDSPGEADQQSAVLDFSARVQHPPGADGVADECPINRIPDELLILIFSYLVEGDLVQCSSVSQSFNRISNDVGLWKQLYIGVHEYTTPLYHSSSSSCKFELREPNRWRNCANAWKESFLLLRHAVHVRPGMNALYNQPGRRISHFECIESALKFVEARPQIAKLVLLHSGHHTPEPIVINSAVQIIGASAGSDLDVMRAVSIESQKDTAISFVDGSLGSYLGYCSVAFNPDKVSLQPHINHYALQITDETDVVIDHVIVHSSSFVGAALCVKKQSANPRLRHCIVSDCENVGIFVSDNAHGRFEDCEIARNNLAGVWVKNHANPLFKRCHIHHGRDVGIFTFENGNGYFEKCNIHSNRISGIEVKLHANPTVVRCDIHNGQTGGIYVHEKGRGQFMENRIYSNEFAGIWITSQSEPTIRKNEIFNGQQGGVYIFGEGRGLIEQNNIYGNALAGIQVRTSSDPIVRLNKIHDGLHGGIYVHEKGKGLIEENEIYGNTLAGIWVTTGSSPILRKNRIHSGKQVGVYFYDNGHGLLEENDIFNHLYSGVQIRTGSNPKITRNKIWGGQNGGVLVYNNGNGVLEDNEIFDNAMAGVWIKTDSNPTLRRNKIYDGRDGGVCIFNRGRGLMEDNDIYRNAQAGVLISTESSPILRRNRIFEGRAAGIEITNGASATLEYNWLYMNRYGGLCLATDVRPSLRDNRIFDNHNAVERAIAKGHCLFKISSCTSFPMHDFYRCVTCNTTDRNAICISCIRICHRGHQVEFVRHDRFFCDCGAGTLEQQNCCLQTEIRDNDTIYDSAQPTESETGSNNPLVGPPVAAGGGGEGNLAPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIB2</accession>
    <name>A0A914HIB2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIB2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17626.t3">
        <property type="protein sequence ID" value="Gr19_v10_g17626.t3"/>
        <property type="gene ID" value="Gr19_v10_g17626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037180137" evidence="3">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17626.t3"/>
        </source>
    </evidence>
    <sequence length="216" mass="22393" checksum="76AC01B91AFF0DA0" modified="2023-02-22" version="1">MIYYSLFEFPFLIISFVALMTEAQDFPPVQPVPAPPAAEPQNMVENATATATTATGFPPTPTGSTPGGPLNRMGNFLSGLVGGEQQQQETTTPGANASDHEALSNNDRVANASSTASANIDAGGIATTVTPPLDNTTSNVFSSTTEMSPSIVEGPEVEVWNFAEGMDNMTTTTSSTSSTTTERPPVPASAAVALNAWAVNLVASAAFAGVVFFHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIG6</accession>
    <name>A0A914HIG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17469.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17469.t1"/>
        <property type="gene ID" value="Gr19_v10_g17469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17469.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17667" checksum="4A82C3607BC185E8" modified="2023-02-22" version="1">MAQKTRQREGSSRLGAGFNRDWVPDSTATGCRIQPRLGAGFNRDWVPDSTALGAGFNRTGCRIQPRLGAGFNRDWVPDSTATGCRIQPRLGAGFNRDWVPDSTATGCRIQPRLGAGFNRDWVPDSTATGCRIQPRLGAGFNRDWVPDSTGFNLDWVPDSGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIY0</accession>
    <name>A0A914HIY0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIY0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17061.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17061.t1"/>
        <property type="gene ID" value="Gr19_v10_g17061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF377">
        <property type="entry name" value="COLLAGEN TYPE IX ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17061.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="27901" checksum="5D0BADE41C9EAEAB" modified="2023-02-22" version="1">MDSEKTRQNEADSLRRLAFFGVALSTVSTLICVLSVPMVYNYVQHVNSQLMAEVDFCKMRSGNIWREVTRTQGMHSEKHHRMVRQTNACCGCGQSPRGPPGPPGTQGNPGADGNPGGAGQAGAPAQAPPRPTQTGTACQTCAPAANGQPGHQGPPGPPGPAGEPGANSAGGGKGPRGPTGPPGSDGKPGNDGAPGQPGAPGQVRAGPVKVGPPGPPGPAGHPGQPGGPGQPGEPGHPGGQGLPGDVGPLGTPGHPGGLGTAGQPGGQGGHGQCDHCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJR8</accession>
    <name>A0A914HJR8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJR8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17830.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17830.t2"/>
        <property type="gene ID" value="Gr19_v10_g17830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036862482" evidence="2">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17830.t2"/>
        </source>
    </evidence>
    <sequence length="225" mass="24984" checksum="9F4D29A5696C953A" modified="2023-02-22" version="1">MNLSVLIFIIFALFVRDTLAGNCSSHKRKKAAHQKQPPATSANDIISTASSDVISPPPAPATQPENSCSSSTDQRLARLEQMLEQFMSMQNVPMLEAFEKQQQQHQHQQVHPSIDKEYPQRMEVLPELANAPISTNLNSNGDAIPEGSNVQNACPPNSDQRLVRLEQMLEHFLRIENVPMLDGRLDALESRVSAWVLAFGKCQSPSADDDDQQQQQQRAGGDQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK72</accession>
    <name>A0A914HK72_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK72"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1884.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1884.t1"/>
        <property type="gene ID" value="Gr19_v10_g1884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1884.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8309" checksum="6ED3F11237A72D68" modified="2023-02-22" version="1">MPSPNPSFTKIDFFSSAQQLVQFSSAQQLVQFSSAQLIGSFLRHNKIGSIFFGTTNWFNFLRHIQSNKYRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKK2</accession>
    <name>A0A914HKK2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKK2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17726.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17726.t1"/>
        <property type="gene ID" value="Gr19_v10_g17726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="211"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17726.t1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60162" checksum="1CF90B992A1E5201" modified="2023-02-22" version="1">MLLSLHFSPHSFLLSSFSTLTPSEQRCGAASGVRVSDARATAQLIDQLDQHILNADSISDRRAKKCHRPMENGAHTNAGGEYGDEYDDNSSSKLFERHRIKALADERENVQKKTFTKWVNSHLIRVNCKIQDLYVDLRDGKMLIKLLEVLSGDRLPRPTRGKMRIHCLENLGSQDIVDGAPRLTLGLVWTVILRFQIQDITFEDVDNQETRSAKEALLLWCQMKTAGYRNVNVRNFTSSWRDGLAFNALIHKHRSDLVEYDGLQKSNALHNLNNAFDVAEKQLGREIDHNLRGHLLPLLQQAETRGHPRQTNWQSDRELMENGALVEKYEQLSSALLEWIRAKIGELNDRQFANSLRAVQQQLTGFNVYRMEEKPPRFQEKGELEMLLFSLLSRMRANNQRAFLPREGRTISWNNWAPDSTRRPACARRGWGRTSGWSARTISARTWPAWRRPTRSTRPSRRREDGPDGTGYKPVEPEVVLERIATKNCSNLPHAVKQTLRPTSGCASSTGTSPTWTRTFGNRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLG6</accession>
    <name>A0A914HLG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1875.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1875.t1"/>
        <property type="gene ID" value="Gr19_v10_g1875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1875.t1"/>
        </source>
    </evidence>
    <sequence length="769" mass="84937" checksum="4F1CDB4F9E5D60BB" modified="2023-02-22" version="1">MASSSVDNIVGKCFKDKYVVLKKIGEGGFGRVYLCENKYANSQLYALKMIQIPKGGRQHHSVDPETEIKIHRSMAEKKGRRFVKILDDFKLDDAVVIVMEYCEAGSLKDFVTKQRGAPMEILLATDVLLQLVDALKLMHSSDIMHRDLTAGNVLVKEISRGQDGVVKRLHVKVTDFGLSKRDVQGQLRTMLGTPAFMAPEVRAGKYTMAADVFSLGSIFYLLLTRKYLPGVATADQQQQQQQRKQQQHIGTEGHHQQHVQLQQQQQQHLNLGCIWGIVLTVNDSVRKLSNDVQAALKSFLVGLLCRENNRILLGEVDNCEYIIWYRMNRKLLDPEMDELCCSASLSGTPAGGGIAAGGYGSGGVRRVSRSGGTGGGGIGVDQQQVRGGGAGAVLVDINRDSALGSDNPSRSGTSRCRHPQLDETGRCRTCSYRPTCSNRPASLMDSGRPVAVASARVALPSGRFENVLPVARIAPPASAFSAPATTTNARGKENIRPPPAATAASTNSASPLRRTTTTAATTRWPLPSALHLHNYVGVNEFGRCSFCRPDPATSADKLHLAVICEKTRSKKDNTVECIVELWRTVDGTAQELRLYEPVSRYTPCPAKGDPFVKKNSRAKLLARIRSEDELALESNQLARAAYQTLGGFYRLAESKINQAYCEEVVGDRKWRLELRWNGFVNVYEGARTARELDLKLLTRQKAEGGQFEEVKEADPLSRADRRRLEELSNLLRTEVNQSVWRRRQFESETAGVGGQARNVRCTIYTRGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLT2</accession>
    <name>A0A914HLT2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLT2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2527.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2527.t1"/>
        <property type="gene ID" value="Gr19_v10_g2527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2527.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10274" checksum="AE1005D06D0A4A3B" modified="2023-02-22" version="1">MRFYAFLVEFSFQLVDTPDHANVEELNMREQHHELYVLARLRLMNSRQRCCTGGRVQRITKALRSASQSPSECKCMNFMRGPSAFAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLZ8</accession>
    <name>A0A914HLZ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2579.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2579.t1"/>
        <property type="gene ID" value="Gr19_v10_g2579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2579.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="29163" checksum="D3ADFA95F1AD11C5" modified="2023-02-22" version="1">MQYRRALSQSMQRSDTAQKSSVVMASGRGRNRRKREYCEDSTIQDEDDSTNPPTKRKRRAFTIHDKIEILDFAKKTSLHAASKHFTVARSTMRVWKKQELDLKKMMESATRKRIQGGGRKPTDADFDTALAEWIKELRVRKLRVSRNMIVTEAQKLVLSWCGRTWMDNELTTKYLEEVFGNFFFGNRLFIWDTFGHPYGSRTRRMERFQMDFHYYASADKKMIMIKLVEEIDLNEDENIGSDFSIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM54</accession>
    <name>A0A914HM54_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM54"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2411.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2411.t1"/>
        <property type="gene ID" value="Gr19_v10_g2411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2411.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8358" checksum="0ABFB70542E5BAA0" modified="2023-02-22" version="1">MTPGCSSPTSHAIHLEWLDELLIPNAQPGRGQLSRRPKGEAESRSAGILCLHFHSWEIHPLHLRIEDDPMGKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HML9</accession>
    <name>A0A914HML9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HML9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g256.t1">
        <property type="protein sequence ID" value="Gr19_v10_g256.t1"/>
        <property type="gene ID" value="Gr19_v10_g256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038100139" evidence="7">
        <location>
            <begin position="34"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="479"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="647"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="690"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g256.t1"/>
        </source>
    </evidence>
    <sequence length="793" mass="88899" checksum="C7E08A41C76674AB" modified="2023-02-22" version="1">MHWNKEFSVNYPKFISSLLLICVVLIFCQSAERTAVDALRIEFKPRDWQSQLKNQTNKWEKQLKGHAIKRARKITKLDQLPDIPKERVQRIIKLQTSKNQYNPCRVVQNLCLNGGTCHAVDGEWFCNCSSKHYGRSCEFLADQSKCDENLCKNNATCYSVKEPRTVPNTKLTPKDVEKCSKNEVKTGKKDGDSSCAFTVTAEYQCWCKLGFEGDFCEFSEGERCCVEDHCNHHGLITDLFHASDAQTCDSGKHCNCTCEENYTGSNCEQVSPCRDLECLNEGKCVFNASVSDEAHCQCPTLGFSLGGVKISGNYCEKIEFDEQLSCNPCGNGGFRSYLNCLRKSVNGIEDKFAKYCGTGLCTDKLGKAFCLNEGQCQVTVANFTDLNPYWPLLLIPMCQCDSERFEGDFCEHELLDECDKKDLSLNLPLFVNVTAERRVSTAGTEEFLRELKNNIFGANSKISVGDSEDRRLASRGFEHILGRAGMRTFCGENGFCRPYNEEAGFECKCNDGFKGTRCEVRDPCSNTKCPDHSLCVDIPALDESNSPNEQNNLTSACICKTNQDINEKTSACMNQQNEYAYTACFNEGQPKCQNNGHCYPCSLDNELVSKIKVDSSRLPLCNQDERNSRIRCICPPGFTTSSLCHNESRPCDFNRCQNDAKCVAVPVPDNVLNYECECKPGYNGSLCEIVEDACRAGATCGNGTCLLDVTLARGFRCDCVYGYFGFDCEQIRATGWVAYFNDNYQWTYPLLAFLLLAPVNLVVVAVQERRTRAKYGALENAPSYYAVLSNYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN65</accession>
    <name>A0A914HN65_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HN65"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g285.t1">
        <property type="protein sequence ID" value="Gr19_v10_g285.t1"/>
        <property type="gene ID" value="Gr19_v10_g285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="745"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g285.t1"/>
        </source>
    </evidence>
    <sequence length="890" mass="99559" checksum="FFE6CA5CC47A4D76" modified="2023-02-22" version="1">MNSLSTEVVICLNSSSNAALESPTGTGKTLSLLCAALSWVQREKKRVGLKKSLAKGFVDQPPCKQSGAPAAVVAAEHYPKIFYASRTHSQLQQVVRELNKTEYKSVVKVATLAGRDQLCINERVLEENNSEIRGHLCRTLVKSQKCDYHFQLDLDKDLLDKMYKAESKGVVMDIEDLTKAARKFRHCPFYLARQMYDSADLILLPYNYLLDPKIRKAYSINMKGNILIFDEAHNMEAIAEESMSVDFSSKSLNVAIRETKKVLELVEDEELNRVPFVEMSKKNQSAKDGGEEDEQRLNKDDLDNLLTRLSNFEKQIAILETDKGGQVHARVPGRVYSGYKMVELMKNAHILRIHRDKICGLIDKIGLFLAGHAERNSGVWSVKGSALAEFASLVSVVFVDSVEVDYRHFQLFVERKECNLDNGEWHNGLVEVDAPGDANAKPGTTELKLNYWCFNAGVAMQFLQSRGTLSIILASGTLAPMQMFKQCMGIPFGCTLESAHCARDDQLIVAALNNGPTGVELDGTFQNRDSSPYKLSIGEVVLLTAKGTPQGMLVFFSSFAQMASILGHWKSCRSSNGQFLWDQLERQKRLLMEPKDKRELSKLFNKFDVAVRENRPTAGRSGGALLFAVCRGKLSEGIDFSDSHCRAVVVVGIPFPPLYDPRIILKKACLAKQGNSMNPNEWYRIEGIRAVNQALGRIIRHKDDFGVVVLADSRFGTFDRRMFPDFVPLVGRFFAERGVLVEQSHAAMGEQKQKEQKNERKRLSHHQQRPLGELQNGNSKPNLSLLDGILELYEIDEQKTAPSTSQKWASEDDEIQVISVQKHMNNSGKSTSTRLGRCLKSNSNGTTTTTKGLLNGGRVGLDLNVNSKWKKAKMRTAELNSEYFEGIDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNZ2</accession>
    <name>A0A914HNZ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNZ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2351.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2351.t1"/>
        <property type="gene ID" value="Gr19_v10_g2351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036964438" evidence="2">
        <location>
            <begin position="27"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2351.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23050" checksum="91B3C33ABE50E8F0" modified="2023-02-22" version="1">MFIKIGFFIFVFFKLLFLAKIDNVSSCSVLLYDNDCCKNKFWQTYELLDCPGPFKPECNIFGHNCVGCTYKYSTAKGCIPRVQCSCYYCCESQYAKNCPDGCRECVIDGVGGCPENSAVHNSSTSSTHESEAKAREHFDMVDVDKNGSISLNEAINHLKSKLKNGPSARNLAVNMSWFAEIDHNGNNQIEPGEFDRSLIGVNDQKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP99</accession>
    <name>A0A914HP99_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Annexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="domain">
        <text evidence="7">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HP99"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g244.t1">
        <property type="protein sequence ID" value="Gr19_v10_g244.t1"/>
        <property type="gene ID" value="Gr19_v10_g244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.220.10">
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        <property type="match status" value="4"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
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        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0041">Annexin</keyword>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 7" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g244.t1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35824" checksum="523A2F50456B5C4D" modified="2023-02-22" version="1">MGTPSIIANPNFDPQAIADLLRRAMKGIGCDKEMVSQTLVSCNNAQRQEVAHVFKQMHGKDLIKELKSELRGDFEDLIVAMMERPAIYDADQLHRAMKGCGTKEHVLIEIMTTRTNSQIHEIKLAYRKKHHTDLEKDIVDDTSGYFRRLLISLCSGARDEQMHTDRTKAQQDAHKLWCAGEARLGTDEIAFNSILAAQNFGQLLLVFDEYQKQHGHSIEKAIRNEFSGDICAAHLALVKSICNRPAYFAELLYKSMKGLGTRDNDLIRLVVTRSEIDMVDIRTAYQKMHGKSLEAAIADDCSGAYKRALIAIVKGNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPZ5</accession>
    <name>A0A914HPZ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPZ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2639.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2639.t1"/>
        <property type="gene ID" value="Gr19_v10_g2639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2639.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10735" checksum="7B48223C8E66B538" modified="2023-02-22" version="1">MGLFSICEIQQDAPPRRRGAELGGLLGFVDNFVAYLAGILVSRTKHFMPSRNFFPEFTPIFAQDEPSVELLKSANIRRFVLSHSFFGFPGLLRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ31</accession>
    <name>A0A914HQ31_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ31"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2658.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2658.t1"/>
        <property type="gene ID" value="Gr19_v10_g2658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2658.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16702" checksum="5A70788A5146D46E" modified="2023-02-22" version="1">MFPARALSYFANAEKTQSMHVSKLVDVDVHFLYRATILVITMEAPNGEEQQTLNILPYRKQCFVEVYCKIVERNGNATVFAFGTGQKEAGTSQIHFPIFNEDNAKKCYEEKINAKIHYDENKEKIVTINVAEFFDASKPITIDLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQQ0</accession>
    <name>A0A914HQQ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQQ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3767.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3767.t1"/>
        <property type="gene ID" value="Gr19_v10_g3767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037194767" evidence="2">
        <location>
            <begin position="24"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="610"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3767.t1"/>
        </source>
    </evidence>
    <sequence length="930" mass="106222" checksum="E302852771DA94EB" modified="2023-02-22" version="1">MNAHLTLAINFFCLLALLHGTQSKMKTKPTRLTGQSTNDHIIPVALLDQCFPYEESKTFGLEFRLPEIGGRCDKGMLICYPSTLITHPLDNKHIVNGMSVNSELFNVDSASKNSLAKECEQLLTGFSNKKHKDKAFWRGIQVYTVKKSDGTIAMKLNTSLVGQGHGHSFEIPQAQRQFIIHLGNEREMFTYVTIDKGEPVEVEGEKAKREAYKQLAPRGARLKDFVGLWTLGLDMLPWMNHTMRLYVQRSCDCFMEAWFIRPTDSEPADLKEPTRGSAQTECSKEAKTDLIVSLKNNPLKANHLIHIRLMASEFTRNVTFKLYASGWKYHIALMSFNISRAGSNVFMRNATSRHMNGGWHIPTRLPDKDGSYQLEFRIALTKYSYGIMIGGIVEHTKYHTDRLGATEFFPPYWWQGLQFNLMDHYQLGGEFLLLNDPPPVMAFKNIEQNYEPVLITDFETTIVRNLQIGSILTFRVKPRNPNAYTFTISLLHNRPEEHPTIGKTVLKIQVYPNKLQLSSNFVDVKKSYSNKAIVVPAIKHDLLEVNITVFSNHYMFMMNGMKLPKNRTADLPIWATNNVLIEGDIDQLGPPHIDVPPASVENNRRDFTKFTKKLHTLLNYNDNITIDMEIYNTSNNFSIYLMNESLEPSKRIGHVVLALNFTVSETTSTQCKYHLHQNGLDEMESNGSDFPNMTSFGHQVDNRLNRNGQRFNMTIKCEENRFVINIDEVDFVALNCPYPTIKDNITMPPWSVDHIQIVGDVYVYALHIEQPEISTPEFLTEVNHAWGVLRQRDRITVHAVINKKLNETLGFNVTVNLFYEALQHHALVGKTVMSTTFNEHADGQQQQLIFSSYDNGKKGERTNTTGFNVTLNDVYVCPHPYMDGLPTWAVHYITIESTNVKLDNATNITCKPQKRCKRPSDQTGSYRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR08</accession>
    <name>A0A914HR08_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR08"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g366.t2">
        <property type="protein sequence ID" value="Gr19_v10_g366.t2"/>
        <property type="gene ID" value="Gr19_v10_g366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g366.t2"/>
        </source>
    </evidence>
    <sequence length="343" mass="37862" checksum="CC274326D509820D" modified="2023-02-22" version="1">MCVLDSDQNDFRSVRSRTPDRLRLFWGCLVVLCVAISTGYGSQLKFSLLNSATAHFYPPFLMMWFNNCCLIICFPLYLIFERIKSKERSVREITAECAQIIAENGLRSGLGRELFFLLLYTIGNYSYALSLGRITSSAALTVRSFDVSLVYLLGHLILSERFITLKTMAVALATGGVLLIAQDHQFAADLVGVFLVLLSCGVDAIYKVSFKWMAGQASFGQGMFFLSGMALVNLPINALPTALLLHFGVERWEWAFVPWSSVIGFVLLTFVFNISTIFGVALLNPLIISIGVLCGIPISIGIDVAFRGKQPTVGFLIGAILLVASTNSLLEKIRRRRGGRGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRF3</accession>
    <name>A0A914HRF3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HRF3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g396.t1">
        <property type="protein sequence ID" value="Gr19_v10_g396.t1"/>
        <property type="gene ID" value="Gr19_v10_g396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010798">
        <property type="entry name" value="Triadin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14106">
        <property type="entry name" value="TRIADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14106:SF0">
        <property type="entry name" value="TRIADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="449"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g396.t1"/>
        </source>
    </evidence>
    <sequence length="622" mass="59748" checksum="9B217EBF5CD311AE" modified="2023-02-22" version="1">MEEETEVEEVTTEEETEVEEVTTEEETEVTTEEETEVEEVTTEEETEVTTEEETEVEEVTTEEETEVTTEEETEVEEVTTEEETEVEEVTTEEETEVTTEEETEVTTEEERSDNGGGNGSDNGGGNGSDNGGGNGSDNGGGNGSDTGGGNGGGGSDNGGGNGSDTGGGNGGGGSDNGGGNGSDNGGGNGSDNGGGNGGGGSDNGRGNGGGAGGVSRGGQGSGSGGGQGGDQGGGQGGGLGGGQGGGQGGGQGGGQGGGLGGGQGGGLGGGQGGGQGGGQGGGQGGGQGGGLGGGQGGGQGGGQGGGQGGGLGGGQGGGQGGGQGGGQGGGQGGGQGGGLGGGGGQGGGQGGGQGGGQGGGQGGGLGGGGGQGGGQGGGQGGGQGGGQGGGQGGGQGGGLGGSQGGGLGGGLGGGQGGGQGGGQGGGQGGEYEVLRREYYKLVATYEKLSENATECIKMYERKVKEYEELRTEKQQLEESNERMNKEYYQMKKEKERMEEMCEEMQNNMTRTEQSKEETEKSYEQLQTSYEQLQSQCTKKEDGQVMVPKPDFPNPCSDNLMNGNCADPTYMKTCIDPSYNTLSMSKCCVTCTKVRTAISASLNISISFTSSSSSSSSQTQTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS46</accession>
    <name>A0A914HS46_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS46"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3236.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3236.t1"/>
        <property type="gene ID" value="Gr19_v10_g3236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3236.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10667" checksum="A6E983AF61460FDA" modified="2023-02-22" version="1">MKEFPTKDPSEFTKEEIMQILLLEKKKDKTTLFYKPKKDSMPEICVPYYNKEGNEAEAYSNGQIKKFVICKNNDCNTVLKCPSGSIKLAYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS79</accession>
    <name>A0A914HS79_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3747.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3747.t1"/>
        <property type="gene ID" value="Gr19_v10_g3747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3747.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42725" checksum="5BD7FDB2D49FC5FA" modified="2023-02-22" version="1">MPSTNSLITEMTAIFISLAFCFVLIGAVCGNFKCHDPLEDEEFDVPGNNVLMTLYKNSNELSNGNGNIELKQFVCDLSERYIVIGKAFDYLAQQKCGFFRRLSNNSAGLRRGACMIDEFELLKTVDELDRPMAQLMYKLYKSISVLKHPIIAENRSPMATECRHRPARMDSALISASDSISSSTAFARSVSAAIGVHQQQRFILILHHENVKNRDLKKFHRLLIKNLEIYAKEEGIKVVDVDQCICDQDLLGSVSRHFDRADQVVMELSPNYADLISATEGASSLADQLAVNDQQQIDQRVRMKLYLRQMTFNEVLLNGNQNRRFRVVLMQGCRPEHIPRGWPGNTLHNRFPQDFEALCQRLFEQQKQRSIDDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT00</accession>
    <name>A0A914HT00_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HT00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3484.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3484.t1"/>
        <property type="gene ID" value="Gr19_v10_g3484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="6">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3484.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34052" checksum="6591971D12CBA697" modified="2023-02-22" version="1">MFVQLEVSEYARINTVLGLLLARDADAPPLDLQRYRIAAGNLTTCPAYGSARYSGNCEANAYEAEWLIGAWPEAPDLGRRCEQRMKDGVRKFRVRWVGYPTPSWQPEENLRDCQEKLDEYFYGHTVHALIERTSILGPLPDQLPCRQRFRFVVVRVPYALLGRLLVLLILAYCAMTDLPTNRFHAVNGSASSSSVCLMPYSAVSLSSDLNFIDHCVGNEPELHMESVAQWYERVFLFHRVWSVDDSVIHTDYSALRSIVMANREETIKMPINEPAKSAQGCVADPGIRGLLGRKRSAGARPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTF6</accession>
    <name>A0A914HTF6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HTF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4298.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4298.t1"/>
        <property type="gene ID" value="Gr19_v10_g4298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="239"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4298.t1"/>
        </source>
    </evidence>
    <sequence length="739" mass="83523" checksum="4BE8398FA2559CF4" modified="2023-02-22" version="1">MPDKDKTELYTDLTDETHFDFCRMAWLERKFLGLCDPLTMCIPESAFVTVVLSTTKSMDVASAVFRLFSKNNNSSIGFREYVYGLSSLCQGPAPERIKFVMQLWDSDMDGWLSRKDLMDCFKFFGLSMVEVLSNSALATVPDAFRLHEFVCLANANPTVRDALLSFSNKIWIALTSKTKSMKSNEGQDNNARKEHDHDKTDADDEQSSSPDEEKEGENGQNLKKTSGKKANTKNRPQLGGVQNIGNTCYMGAAIQTLANVSELTGFLFKNEQQFFHLPLVRRYIQMLRTLLVQRETASPLDLKEAISAKSALFAENVQHDSQEFMQFFLDALNESLKNIQIGEELENKKATDEGGRADDGNVQEDGIGMWQNANNHWKKEALTSKERSIVLDLFAGQFLSKLHCQNCAHSSNTFELFTMLQLQIPIPESICVFFKVVRRDSDAVVRHAMRIPSITELVHLKQLICERIGIATDDVEILIQNKHGGNCNADFSQMFNAKSARRGRADCTLMGIPLCDINIWCIEIKNLFADCSDCLIDAINQKTHTLNDPSLLKADRQTDARLLNVDDCVRDFTGVEQIDGSHCDNCKSSASKLSKQLSFTRLPDILVVCFKRFIFVPSLKRFVKQSAPLSFPLDNFDPRPYFAPDVPQQFLNNFSRYFCIGIVTHSGQLNYGHYCSYVLNVSSKRWFFCNDDKIELIKSGCVPTPKDAYILFYQRATDTPSAPAMRREDATRKDNNVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUW3</accession>
    <name>A0A914HUW3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HUW3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g421.t1">
        <property type="protein sequence ID" value="Gr19_v10_g421.t1"/>
        <property type="gene ID" value="Gr19_v10_g421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097524">
        <property type="term" value="C:sperm plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043401">
        <property type="term" value="P:steroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF45">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g421.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44039" checksum="55ECB0B1C8B9374E" modified="2023-02-22" version="1">MQFVFSLAPSFEALLASPGYAIFFIFLLLIARFLKLTSFDEKPRITRRKNKRQNSSRKCSEEDDQCAKIDLGELFGQCSILQEPYTPPAIWGRNGHIQTMAYGLLGHHSLRRTFDNRHLLRLLDGTTATFDVFEPVCAHQNGGDFTLVFCPGIANCSESNYIRTCVHLVQEKAYFTEDFFIWRKRMGANVLTNCFAGLDREICSRVLLGISVCQGYCASDGASLLFDWEGGRRLYNYIITENLKRLLRRNYTMAVQPYVRTGLVDEQKLWSSTSLLWFDECYSRRVHNFTSDIKIPMIFVNTLDDPLVPEALWDPVRQLCESHPLHSFVLLKHGGHLGFLEGNSLRPRSVTWLDRFILEMAEAARAHVEQSEMSATGTSFEEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVK9</accession>
    <name>A0A914HVK9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVK9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4389.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4389.t1"/>
        <property type="gene ID" value="Gr19_v10_g4389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4389.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="26182" checksum="BA8BBCAD0E5DA0FC" modified="2023-02-22" version="1">MSQRLWLPPELVYELLSFVPSAFLGARHLLRTNAILYWLIIGGKYANKWRHPYLVGEREAHWANYRIGSIKRRPLCPRIHRNNFPIFCLNVWHYGRFRANDISDFQAILILDRSRFPPWFNMRRLRRELCSRINERSHEWTGVMLSCRPFHHPSLEYDTLRMTFACVRDELFHATACEPAGISGEQNDICKKVHQILEMAGKFSAIFSSFFLLACEIRNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWM0</accession>
    <name>A0A914HWM0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914HWM0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5337.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5337.t1"/>
        <property type="gene ID" value="Gr19_v10_g5337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000028">
        <property type="entry name" value="Zinc metalloproteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF831">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="124"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="358"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5337.t1"/>
        </source>
    </evidence>
    <sequence length="781" mass="87210" checksum="0810127C487D9607" modified="2023-02-22" version="1">MFTGFGRGSPIKNNSETTTAEERPAQHQIGAEFVEVRRLLDQIKIASIKQHGRFSDQDPTRERARQQLRDRVIINDGTEASINRAVADDLFENDILLTLPQANQILQEIKEAPTSSHKRRGRRQANPTPSSIWGSVNIPYVFQLSQTDSNWQNNIRNGQRHIESLTCVRFVFHNSEYALKGKDFLQYFRGTGCWSQVGKTGGRQPISIGYGCESLGIVAHETLHALGLWHEQSRLDRDKFVRINYDSILPGTESNFEKRTPDTSDNMGQPYDLGSAMHYGNKAFTSDFRSFTILTLDRTYQQTIGQRGGLSFKDARMINTRYCSEICTNKLDCEHGGYTDPMNCGQCRCPDGYAGDYCQSIPTSNSEACLNPGEFTAGRWPGSLKTSALVARASCHWRIHPLHEKHRVVLNIEKLDMPCKDSCASFLELKYKKDKIATGARLCCGNPGTIYADIGTDVLVILRSESKLDSKYKGFELTYKSEGDPITITPTAKPIIGVTTPTKTTETPTTKTTTTETTTTETTTTPKTTTTETTTTETTTTETTTTPKTTTTETTEEPPTTTVEEGIWSKWGGWSGCSASCGACGQRRRVRTCFRGKCKGEPLQVERCSFGVCRLTKHRTNRCQGRLVMPCDLLESLEFGTVIKYDGIRQADNDSLGDQTVPMLDSNILLETKSRSRRHFDELTGGNFPTLLLAENADLPGRSRRQADDEMAETPKVFCEKRFSYNCPTTLLTISMDWQQTKSAGNHHKSNGNVDEGDDHRDRECCPGFTPSEGQCVLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXU6</accession>
    <name>A0A914HXU6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXU6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5478.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5478.t1"/>
        <property type="gene ID" value="Gr19_v10_g5478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF264">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER ON CHROMOSOME X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5478.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32040" checksum="0C21D591DC01CD15" modified="2023-02-22" version="1">MQTIIEPHLAVNVLANAQLFASFAHRLEDSRIRSPRAVFVSSCTAHAGDLSLLLQDEEKFWCHRINGYKAYADSKLLLSVYVKYLNGILKYRQSKIAVVSVHPGVVPGKLYRNVFAPFRLVLNVFLRPFLRSPLLAATRVLDVAFADDLLEGSYYENGRVTALKLDHLHLINHLCRLLHSLPSVVAMSCCPLRLLSLLALCLLLSFVGLSTGQYFSNAVNPYNNYFYNPYAYSSNSNSRSSSNNNGYYGYGGYGYGNNYYSGGSNWYGGSSASNGLFRYCNPCYDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ25</accession>
    <name>A0A914HZ25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5113.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5113.t1"/>
        <property type="gene ID" value="Gr19_v10_g5113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5113.t1"/>
        </source>
    </evidence>
    <sequence length="660" mass="77863" checksum="90664B071D091772" modified="2023-02-22" version="1">MPPKRQNEQFVEESQKPNFGDSSKENNGARKFKQEKPDNDVIILNDDDDDDRKPLLEKPALTKRGRKPRWDKQQQEQEELPPKKIRANESDGDEKSQTSVFDYPTIFWKLARPKYGTFTFMCKDCQNANFLLGDRRFVLAPQNGDGRLEFTQTFCRDCAKLNFDCTDLIMKHQKKLAPTKNGHYHPYTGGNWATVGTLEKQYVIVHLRDGRKYRFRVPSGSFLSPQQLERGIHHGMIAEMERLMTRKRAALVEEEGELFDLEVVEEEQGVEPPGEAPLLPLRNETATQERERAQKEQKERLAYEKENDRLRRLEEDRKEKDRLENERKAKRQKWLEDGRKETERQRQEAARKEIERLQRIENATNENERKEKERKENERKENERKENELKESERVGKLKQESASQDKNKEEERMRRDQERKFKLRELELLKELKPYRGGWMRLVQGKDPTPDVHYLHEKDEYHFANAVDKYRIYHPELPWDLPAFNPSAQIQRNIAEFKGLFEREVYDENYGSKTREEKEELLVLVKGFRFYYMEDIGRFMLKIFDNKISHITLTDQLAYVLGYEQEQQILSDDLAKYSVDLGGGVSHLCIYLNSGIIESMIFGNTFANLLQVIAVEGKSGSVVEKDFQSPLFHKIIAREVDVLDVEIRTLTGRYVYAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ36</accession>
    <name>A0A914HZ36_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine incorporator</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5815.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5815.t1"/>
        <property type="gene ID" value="Gr19_v10_g5815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5815.t1"/>
        </source>
    </evidence>
    <sequence length="460" mass="50598" checksum="5A318B4C70EF2E8F" modified="2023-02-22" version="1">MGALMAAPACAASLACCFGGTACSMCCAFCPNSKNSSTTRVMYALMLLVGTMVSCVMLSEWVQKLLAQGGWFCTATGGAGIPVCDMVTGYQAVYRICMGMAAFFFLFMLLMLGVKSSRDGRAPIQNGFWFFKYLLLGLLIFGFFYLRDGGWAIPMMWIGMLGAFVFILIQLVLIVDFAHGIAENWVNTYEESESRWCFAGMIIFTLGTFALSIASVVFMFIYYTTGSACVLPKFIISINLILCFVISVVSLLPKVQERMPNSGLLQASMMSLYVCYLTWSALTNNPDRDCNPSLIPRHNSTGDSGGTVQVITTSLPVNSIVSLIIWFCCLLYASIRTSSYTALGKIGGAVSEGNAEGQDIPLSEASMSVEEGDRGAGRNVFDNERGSVAYSYSFFHFIFALASLYVMMTLTSWYTPSDDLRYLNDNMASLWVRVVSSWLCVALYLWTLMAPVLFPDRDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ80</accession>
    <name>A0A914HZ80_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ80"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5851.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5851.t1"/>
        <property type="gene ID" value="Gr19_v10_g5851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5851.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="22334" checksum="83E125A2961B6D8B" modified="2023-02-22" version="1">MSRFWDQVEGGTIKGRRYPDAFGGTIPAFGLVAVSSKPLSPPIGKSAEHRGGRVAASSLESTGSRDDLEEADSWKRNAVLLALIWGALFISSPSSVVQCGRSGGGRGKGSGSSNTSGGRGGGGSSGGGSRQRGGGSGRGGRDAAGRGGRGGGRRPAPVNNADEEEEESCRLSLGIRSGHVRFRYCRSRLNRSKKRNVRAVQPTGIPYSQVSNSTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZR8</accession>
    <name>A0A914HZR8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZR8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6168.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6168.t2"/>
        <property type="gene ID" value="Gr19_v10_g6168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029162">
        <property type="entry name" value="InaF-motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34929:SF1">
        <property type="entry name" value="INAF MOTIF CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34929">
        <property type="entry name" value="ZGC:153157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15018">
        <property type="entry name" value="InaF-motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6168.t2"/>
        </source>
    </evidence>
    <sequence length="155" mass="17040" checksum="15716314E34F9641" modified="2023-02-22" version="1">MRNSSTAPSIESSANPVPSTTKPTSAAHSCIRNSNYRPSQPRPVNSNSTLRSNASSAFYYSGGQRRRSRPFTYGFGVGGGRKNKESQTWIRCLTVIAYFCIVSLPALLLSYYYTRVWDPTYLNALIANPQNFSDLAFLSAGTAKRTALLGKLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZS9</accession>
    <name>A0A914HZS9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZS9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6174.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6174.t2"/>
        <property type="gene ID" value="Gr19_v10_g6174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6174.t2"/>
        </source>
    </evidence>
    <sequence length="202" mass="21444" checksum="C67E1346D3DD7D6D" modified="2023-02-22" version="1">MRCASPLEERVGRERVGRERVGGSELSGSELFRNELAENELDENELAENELAGNELAGSELSRNELAENELAENELAGNELAGSELSRNELAENELDENELAGNELAGNELAGNELAGNELAGNELPGNELAVNGWAGNELAGNELAGSELSRNELAENELAENELAENELAGSELSGSELSRNELAVNELAGNELAGSDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1L3</accession>
    <name>A0A914I1L3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1L3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5760.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5760.t1"/>
        <property type="gene ID" value="Gr19_v10_g5760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5760.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13447" checksum="C8758FC2008D7EFD" modified="2023-02-22" version="1">METLKKSVGRPKRPLSNCKVCGRPSLYCYYGVKCCESCKQFFHRVVAKQTLFNCFGRKKCRIEENWIRCRGCRLDKCLLVGMDPTKINVVNDRFGHFLTILELRRRNVLERIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1S8</accession>
    <name>A0A914I1S8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Syndecan/Neurexin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syndecan proteoglycan family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1S8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6092.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6092.t2"/>
        <property type="gene ID" value="Gr19_v10_g6092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001050">
        <property type="entry name" value="Syndecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027789">
        <property type="entry name" value="Syndecan/Neurexin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915:SF1">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Syndecan"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0357">Heparan sulfate</keyword>
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    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Syndecan/Neurexin" evidence="11">
        <location>
            <begin position="274"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6092.t2"/>
        </source>
    </evidence>
    <sequence length="336" mass="36907" checksum="C5B3BC0FC02D3EA2" modified="2023-02-22" version="1">MMAGVPSFLRPFVFSPVVILYYLQFRSQTLFLFCQAKMRKSLSSNFHPAGGVRLPMLIVMAIILISERLSAAGPTEFNSDAGRNEIVQKRPSEGHAKNSPTKSASSVDPPNWEGSGANPDDEDGDVDEEGSGDEPPAEGSGSPPDEFERRKQNEAITDPRLPAQFGANGKQQYANTTTTVTDLQTTTTTTTVMLATTLRPPLMKPLTEAPTTTALSNSLPRTAPTTTLPRMVKPIHEGKWPPSRSTSPPFAPTRTSKRPFFIADDPSGTLEQLRPGIFAFMVGGVVVGLLLLILIISYLVYRLKKRDEGTYICEEPHQQAHYPYAYQKASIREFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2G2</accession>
    <name>A0A914I2G2_GLORO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2G2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6256.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6256.t1"/>
        <property type="gene ID" value="Gr19_v10_g6256"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6256.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8856" checksum="E78AE2D80F1CC31D" modified="2023-02-22" version="1">MIKDLLPYGEAFFDYNVQEALEISCHRQAVKISVARRSRVSVLSKALLNNNKLKDAKAFRTTANSLPYDKKRANLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2U5</accession>
    <name>A0A914I2U5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I2U5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6321.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6321.t1"/>
        <property type="gene ID" value="Gr19_v10_g6321"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004930">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7TM_GPCR_Srsx"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="45"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6321.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38356" checksum="2E4ED3F50585E185" modified="2023-02-22" version="1">MNATLQETASNSSNYYIAFQRDGVPLGFTVLVVVRFIIAIIGVVFNACLLYVAVTTYALQGSCNFLIAFNAFCLVMFLPFMGVGVFKCSFVPIQTCFWWQFIPMFFGNLFIISTLAIAIDRLLSVLFSAWHSRHNTEFSYLSSVLTICVLYSTCIVYICYIAAMKPVDVLVLCLNPADAYRGQIGIALFSLSLTAVSLCIVCYLIIWRSVRKNRSTWNGTFTMKILSSLFVIILLISFGYFLSTMIRVIALFMQFSQFAYIVFVSSMFSVLAMAANAPVLCIFSSDYQIAFREHFPLLFHRSTEVGGGRFNRGTTPVPERIFSRTNVEEWPRREMGHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4A3</accession>
    <name>A0A914I4A3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4A3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6680.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6680.t1"/>
        <property type="gene ID" value="Gr19_v10_g6680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032029">
        <property type="entry name" value="ADAM17_MPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF6">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16698">
        <property type="entry name" value="ADAM17_MPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036880541" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="954"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="7">
        <location>
            <begin position="490"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="6">
        <location>
            <begin position="734"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6680.t1"/>
        </source>
    </evidence>
    <sequence length="1118" mass="121806" checksum="3938114CA25B1AD3" modified="2023-02-22" version="1">MIALTLIPLHLLTFIVAAVFIVLAQCCACCKGKRVPSFASANDSNYSTLGKLDARIFVEKKPGTTKGTPAVAVKKPETPKGTPAVAVKKPETPKGTPAVAEKKPEAPKGTPAVAVKKPETPKGTPAVAEKKPEAPKGTPAVRCRKENKRPKIVKDPTAAQRAQPGDPTAAQRAQPGDPTAAMLVQPDPTTAMLVQPGDPTAAQRVQHADPTAAMLVQPAEKLESSRSQIMAFASRVPTWHEYDRFKVDIWSFGVVGFQCANCGSAAKSPLQIPFSAWLVRSAIDTLLTFEPNIRPNISDCVKLPWFTSVADVTESSTSRGNARCTQSTVAAMDRAPSFFLALLELSTLRGFDILRGFNFAGSAGTSVVIELKDETAVEGVVDSADPKSLNTQLSNVVLYRRRQKGLRPLHLPNFFVKGKYIRFVHFENYATALHLLKQSLRKKLFVSMFVLLFKHILQFFRRFFSPFAMSLLILLTLCPFCATLKEIARNRCELKLVADYEFFRVIGNGNYANAARYLINLIERVNGIFGSVDWGLDITGHRLVNIGFAIKEIKILDKPNFSSSTHFNAAMRPVDGVNSMEMLDSFSAEEGTNATCLCLLVTAKVLSSGVLGLANIGYQNEFFKRGICAREIENGTFYRNTALFSVRRRHELMITRVVDLVAAHELGHAFGSTHDDVHDADCVPQPSRDGRYMMWESANTGYERNHYQFSPCSVRAIHRVLYSLAHRCFVEERRALCGNGILEAGEQCDCGAQIGGTGPAGEGDRCCTADCRLKPSALCSPRHSECCTNNCTFMERGRLCQGRSEEMCKDESRCSGISDKCPPPNPLADGTVCPDEGKCRAGECISFCASLSADLSPCLCEEDKNACRRCCRSRQHSGGADGGGGHCAPVQPFRWLPEGSMCVHGQCQRSETTTGGGGQKAMMCEKKATDSASFFHRLLDNFKGPAPRKFFTDYLVFIVVTVTLFIWFPSGVFIMCMDQQKHKQLVQKRVAAEHNVQVVRSRKRVTPQRSRTLNGIATITTANGNAGGGTTTASGQQQLRQRTPHVSRSSDALQSLLMRNGGGDALAAGTSGGCGGGGESSRQRRVVTVVELGKNNTNNNQTQLASTSAQLSERRAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4C1</accession>
    <name>A0A914I4C1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U3 small nucleolar RNA-associated protein 15 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4C1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7189.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7189.t1"/>
        <property type="gene ID" value="Gr19_v10_g7189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="10">
        <location>
            <begin position="449"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7189.t1"/>
        </source>
    </evidence>
    <sequence length="605" mass="67297" checksum="9AACEE643D3E47F3" modified="2023-02-22" version="1">MRTKQKKGKDMLSAAKRARTHYKPIAWTEHEAVDGEHFGCSDAERYWMDMEEAAVFEAQGNVTSCDFSPMSPPLLASTSGKEMTTFDARKCEPKTIYSKFKERTNSAKFRADGSLLGVTTHAGELMFFDTQSESQQRHWARNAIRTLHAHRCAVNAFCYDRSGRKVFSLADDGRTKLFDLAAASSADGAMPLWECEAHADAIRTGVESPTSEHILVTGSYDHTVKLWDIRSDGAVPVKQFDHGAPVERVLYIRNDDILASAGASTVKIWDLNTGKLLANIENHNKTVTSLCLANDGACLLTGGIDRRVNVVRLDDNCTYAVLHSMHLEWPVLSLAVSPDDSFLAFGMPNRLALHRRQPQKTAAVNGTTTTNGGGMQQQNVKRKKPKNVKGFDEQIVADIQMEGTNGWAKGGGRTAQKHPARAMKMEIVQRDRILGTESVPVELTEQQLDKLSLGTHDRLLRQGAFKELIGKMLRNAQAPADLVVATFGQIRIRNCLDQALADHDKQELKQLFLFLRRNLFVASYFDILYDVATVAIDIYAGKPLQKDVRSNIKLLEAQISQEVHVQEVLCETIGVLKMVLHWNEMKNKKAAADTMENGAIETKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4U8</accession>
    <name>A0A914I4U8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4U8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6899.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6899.t1"/>
        <property type="gene ID" value="Gr19_v10_g6899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6899.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8871" checksum="7ACFB498A667F045" modified="2023-02-22" version="1">MPPFDDTNDNTAPRQPPQPVQNNGRRSPDEEDENGALMEMYDNAQQVLRDWGPQTGPRVIAAIRAYAVNRGIQWPHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5I5</accession>
    <name>A0A914I5I5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ectonucleotide pyrophosphatase/phosphodiesterase family member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5I5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7513.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7513.t1"/>
        <property type="gene ID" value="Gr19_v10_g7513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF114">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="779"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7513.t1"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111225" checksum="6B75E97C6F130A4B" modified="2023-02-22" version="1">MKKSGESSSSSTLDSPSPSSSSSTTALAPLEESTAQVAVDETESAMSISEFHTVSLRSPAVLPVVLSLVQNDGQQQTTTPMLDNGLEMPAGDVLLGCETKNDELPVAKTPEGNSNAQLIALPQVSVPTSKWPPTPLTARLLSSHRFLLALVFLLSAVAIILIVSLAVVIALNNAQLQQTPEEDAAFLNKDISWRSNCERKCNAKFDVPPLLLISMDGFRADFLQRGKTEAVSRISQCGATTEYMMPSYPSKTFPNHFTIATGLYPESHGIVDNYFYDEQMPDEKMFARSSRNPAWYIGEPIWNTVAKNGKKSAIFFWPGSEVPIQGIRPTYRYSYNATIPFSKRVDQVINWLRLDENERPTFLAIYFEQPDTAMHQEGPDSDAVNSALIYVDAMINYLMQQLDNNGFLGCINLIIVSDHGAQKLRDDMAVALDRFVDAADPGILEVFPGIIGQIKLRENNSTLLNKVLAPFECSGGQIFRVYTRDSMPRRYHYTRSGRIGEVVIDSAVGTKLFRTVKQMNGSTMKGEHGYDNRVSSMRAVFGAWEHRAVQPVHSTDAVACDRASNELFSLFAPNNGTPGRLHSLLRSPPSVDLEPLVELAECAGARLVKCGDGCHFELHYSGQSSGSVSMPSSPSSAGPDEPSASDGAGESSGPRPDQSASTTKVPIYSSQHCKYVEHLLIPAQLYQRMPMCTLRMCNATLVFNLRWRVPNFVESQLTAPVPNIDHRGADDENGDGSGERPMPTATTPPASTTMTTSTTNGEETNEIMESFEDQMVERPMGNQQQTEDNSLPSMADQETERPTQSTPTSHEQCVRLGTLANNASGNAWISLFSDNDYARYIHQGKIRVPIGFYNGVWQQILSLIRQYVQHYKRLLMWSGPVWDHDNDGLVDWDSATADAAATSPSHVFLILLRCPGADQWDARGRWCSRPENTSTLSFVLPLLERDLNCLFPVEYIFRHTSRIRDIELLTGNEWFTDRTVYPHELALQLRTYINDQLWQLELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5N8</accession>
    <name>A0A914I5N8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RanBP2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5N8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g755.t1">
        <property type="protein sequence ID" value="Gr19_v10_g755.t1"/>
        <property type="gene ID" value="Gr19_v10_g755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="821"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g755.t1"/>
        </source>
    </evidence>
    <sequence length="849" mass="94199" checksum="23CB0508154B38D5" modified="2023-02-22" version="1">MGECSSNNTEPKPSQKWTCAYCTYRNWEAGLKCVICCQPRNRPMIIEEIGAIEDFGKNLSFGSTTMSTTALPALSSDRLVEDAAPRWSCPSCTYLNCRRTKRCVICDTERPSRFVDQTPPGTGENQTNRNEEKFGGGAQFVLSKELLNKWSCAACTFDNWPTAPKCTICGRSRSMPAGGDENEAMAADKKLQQRQRLSRTPSPKDSGTADNSTNNSEQQKHLERLNSLSIGDHHYHQNEQQQHNKGLDYTSALDIYVRRYLGNEPVEKLFFRAMRAIGQGELQMVNRVVDFLINDGNLQRALTAFEARLLNQRGAAPIDCCTFERADSLLFLAKKCDSPELLKLCRCFSSSASLSSSGGGDDGGAAADNSSSNDISALPCALNCMARTRLYTRVTQCMAFRDGAATFKCQFVAHPHNFSILKLPPQSAGSCADDLALTVQTAILRPAPSIPPQFCYLDCFDSMANRGGVIVGRPPNFLMRNRGGPNTLYDAIFQCMFGVCDRFNILRSALKYTLRRSSHLFKIRWLDAQLKMARDCGLSAFGQGDMENDWADVLNAVDADDECPEPIHIWALAHVVCRPIVVHSMDAPIDVDQLLAAVNSQSMPGGDETDANLALAKRQHNAPQNHYEGIYLPVLWASPPVTRSPLFICHRNGHFHAVVVSDDIYQRDFEVQRYLRIVRRAPRRPGVPEPLFRFLTRAEADNSAFLSQFVLFGECSVAHLSIRREAHPFLPEALALYRGWLHALLQAADDIEAVPTPCSTRAAVMPQLATRIDAHAQQQQHQKNWRAHAHNTAVSALLAPAVTQQQAAATAAPFSRQRSFAYSSATGRLQQQQQDADGDEQRQHSDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5T5</accession>
    <name>A0A914I5T5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5T5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7782.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7782.t1"/>
        <property type="gene ID" value="Gr19_v10_g7782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7782.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31734" checksum="132AAE323A150C16" modified="2023-02-22" version="1">MSFSVIDKQSAESSFDEMPMPTAEMSGESDVSESLPLPLSRSTSSSSFTRRSWTDLKAETNISDEEDEHGKTPRHLDSDSTFGGFGCDFDDNESDEFKRNVAKLAIFGIIVAMVFGKFFYIWSADDSTNSDEMSGENGTKLRAELDRMVAEKWEFELKLVQLRDHLEAERILRGEVEKELWKAHERLETELDERIRLQTELGKNRAELLEAEQRATEAEKEADNKWMGGGFVQLNKLYRKAKETEWARGDLKETSEWWVPLYWRVVRVTFFKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I681</accession>
    <name>A0A914I681_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I681"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7145.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7145.t1"/>
        <property type="gene ID" value="Gr19_v10_g7145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7145.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18092" checksum="A9B4BDFD576B6BAC" modified="2023-02-22" version="1">MTIIINSRPPVPIQPRSSYSQSVVLQHKMGPIHSPTATAAAAAIVSNFPLPPFQTLLISGQTAATSLMMSSSFPSRKKGPPMFRPERVFRTGSKSKGRAAAGRVQRRMDDDAGREKTTNTDEHERWKKEEEEEEEEEEGEEEEGRTRKEEKEDGGRKGKGPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6M9</accession>
    <name>A0A914I6M9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7596 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6M9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g799.t1">
        <property type="protein sequence ID" value="Gr19_v10_g799.t1"/>
        <property type="gene ID" value="Gr19_v10_g799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056017">
        <property type="entry name" value="DUF7596"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24524">
        <property type="entry name" value="DUF7596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7596" evidence="1">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g799.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33762" checksum="4540F6E29A0E48E8" modified="2023-02-22" version="1">MSAAAVLPSLPAKCPLPVQNIPKSTSASIEDQQGKLVAHCVLVQCTKGQAYLIIQQLDNSVAPKAVTLSVPDMDRPFDLKIKTISDAHPNRMHLPVYIQVHYNPEERCPLEHLVDLLAETVLGRHNFELRKNLTIDLFDSAANAAIRDGAGFIVTDRHRLQQISVGAKQARAVLAPTNEVLISPASDDPAELLQYDATLSTHQRADFLRFLMKECKNVLVAHWSSAKLAADALKIEKENKKEKEGKGVNSEKEEVANTVAGYLIASGERVLCLYAENYKIADSLLAAHIDRNQQKGTVINGFIYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7A2</accession>
    <name>A0A914I7A2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 58</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHOC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7A2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7569.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7569.t1"/>
        <property type="gene ID" value="Gr19_v10_g7569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF196">
        <property type="entry name" value="GH17740P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="5">
        <location>
            <begin position="141"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7569.t1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51668" checksum="2960EF530EB06860" modified="2023-02-22" version="1">MANVGGEEQQQQIHNVNGSGDERDRDVHDDSDEEEEEGGGEPPQRAYSICLDRTKMDNFLFWTLAPSKRLSPPPITDGASFHHQREEVVQMHSVDLSQRYIDTLPASFFLGDHAPYKDHAAIALLNLAHNQFVYLPPMVPQFINLISLDISNNQLATLPKEISSLKSLRELSLRNNLLENLPKEFQRLQCLQELNMSGNLLEQFPRELLQIKSLRVLYLGANRLQSLPSGIARLTNLQVLYLGGNALVDVPETIGRLFELTSLGLADNRLEQIPAAIADLRNLRNLALHNNRLKVLPPGIARLKNLEYLSLRNNPLVTDFVNEILLEPPSLKELAARIVKIRFPPNVYRSVFPGDLVDYLSTANHCVNPKCKGVYFEACAELVKFVDFCGKYRVPLLHYLCSPRCSTNTPAYAYSSGSSSESDDDLFQQHLQRNANQRAHHPCTTSSISANAKMKKVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9H1</accession>
    <name>A0A914I9H1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9H1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7855.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7855.t1"/>
        <property type="gene ID" value="Gr19_v10_g7855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7855.t1"/>
        </source>
    </evidence>
    <sequence length="442" mass="48932" checksum="C1CE7429CF5D38C8" modified="2023-02-22" version="1">MNSRPRGRGRGAIRPSASPFAWASTPPTTSTTSSISRRVIVPNFAAAGRLVEPKAEPKTEITSPAGKEANTSKSNHVNNRGHNRGRGRPKAKGTLQREEQRIIKSEGVFSQGFGDADVSGKRSKLKNIKGDETVVGHLENSINCVGRDFKTEIEDKKEVLKRAPKRENGTLNAYEEHWQSDEEVDKEELDELFRDGFISNLKKCSKMPFVLPSKDEAQFRKLVNKKERREEHMDELMESERKDTQLVNKTHEAKFFAAGDLLQHAISGEGANSIMFFQLPPTSLRTVSADSLQPDQLSQTVTASNPPNLTKTQRHCLDGMPTGVQIGKLQFYRSGRVMMNIGGQQMDIAEAIQSNCYEALLRIETESLSQPSASLPTTSLTGTQHKRQFPELNSGAPFVNPSTAFARPSNRIANNAQLLGEVSGQFVCLFDVQRSSIDNGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9R4</accession>
    <name>A0A914I9R4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex which is a heterotetramer of gins1, gins2, gins3 and gins4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9R4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g86.t1">
        <property type="protein sequence ID" value="Gr19_v10_g86.t1"/>
        <property type="gene ID" value="Gr19_v10_g86"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="65"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g86.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20615" checksum="1C0CDD9614D76AFC" modified="2023-02-22" version="1">MNPSLCEFLAENEQIRVVPNFNDRTVHLFCGDFGPFEAGAPVTIPFWLAMLLKRRRKCAIIPPDWLSVDEVRKLIVSESEQSTFAPIPECFFELSNLLMVNAREDVEQYEQLKTLVKDLWDKREAKMRTSTIKFLGQYEIGHAQLDNLTRLEICCARATLIEGSKELDRLTVALHSIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAJ0</accession>
    <name>A0A914IAJ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAJ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8117.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8117.t1"/>
        <property type="gene ID" value="Gr19_v10_g8117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8117.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8289" checksum="D195E0BAEF882774" modified="2023-02-22" version="1">MVIWMPKWKEPVSPTKRATIKRRKEGILEEGILEEGIWEEGILEEGILEEGILEEGILEEGIWGEGIWEEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB33</accession>
    <name>A0A914IB33_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914IB33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8317.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8317.t2"/>
        <property type="gene ID" value="Gr19_v10_g8317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="9">
        <location>
            <begin position="124"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="9">
        <location>
            <begin position="245"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="458"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8317.t2"/>
        </source>
    </evidence>
    <sequence length="694" mass="77100" checksum="83373268C5D22F3F" modified="2023-02-22" version="1">MSNVWTSRAPSVEKTVRQQRVHTLLQTNDGPKRLSTVATICLPMINTDAQQLSLSPSGTKTATLVEFKNGTAAEGDRKQFIRVIDNGTGAEICCANVSGLNKHGPIIGGHFGSEQRLTDRLAKFHDAGLEWGETDKMEKKLLGEKFQLRDSWGEQCANVKQPVICVFKISDQSVELFDEEWLGKVTPQSLVWSPDDSSVVFVGLDNEPFRLGRIFCSNRKGLLYPFISHRMANICWLLLEMRGIGPHNASMALCQFGWDPSLNSAQRLEVLIPTVDSPPPSDRTSFPGCFDPGVPSRAWSRDSRFFFFTTTWHNKTKIIRVDLHNGGQWACVASEHLEGNWTLVDVFGDFLLAQHAAPNRPHSLHIADLGSAVDASEPSDWWHSLNSFEKDQKGKVGAMWDWRTVAFKREEGEQYEGILIWPRTDANNAGEQKQKLGLVVTPHGGPHAASTCTWIHRDQQMLLENGYALLMVNYHGSIGYGDRFVCSLPGRCGELDVEDVHYAVQTTLVSSPDLLDPNRVALYGGSHGGFLVSHLIGQYPDFYKSCVALNPVLDIASMWAVTDIPDWAIYEGTGRFPDYWPTDGRRRSPADLAPSSEERERMHKASPIAHVHKVKTPYLLLIGEKDLRVAPHYKGFVGVLKANGVKCKVLSYPSSCHPLEEVDVEADLAVNMVKWFYETVSTASDNGAGADGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC90</accession>
    <name>A0A914IC90_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IC90"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9492.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9492.t1"/>
        <property type="gene ID" value="Gr19_v10_g9492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9492.t1"/>
        </source>
    </evidence>
    <sequence length="547" mass="62647" checksum="AE5A78B98B026B44" modified="2023-02-22" version="1">MSSKALNVRVITMEAELEFSILPSTTGKQLFDQVKVLKQDIKKEQNLQFKFRAKFYPEDVAEEIIQDVTLRLFYLQVKDLLLTDEAKYGDHAKEEHGSGSLASDRLIPQRVLNQFKMNMSEWENRVITWWADHRGMNRETAMLEYLKIAQDLDQYGYFSIRNKKGSELFLGVDALGLTIYDQQNDKLNPKVGFPWSEICNISFNDKKFVIKPVDQKAQDFVFYAPRLRINKRILTLRQTLIKRADTLDLELNNFRTSIEELSDHIEQVATEIGRRMEYHATCDKVATLSKGPWRTVQPCPPVRAQSVTVPDNSISQGREPDADHQLGFLVEFFYTRPKIQEPGGIVLRGIHARANNQGAYVVVLSDDNVSGQRAKSETGQERSNRVLRGSVLPSVLFVLRDGQYITSIRNVRSDQSVNNNRKSVNNKFKQQKSVYNKVKQRKVGNNKHQTAHQVHQTAQQVHKRHDTKQAWTTSPSSTASAQSCTDTHSDVDNESKQHIKRSEWNRPQTNPGQRVQAAHREFKGNSGHCSQYTIGQVVSALVSFSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF18</accession>
    <name>A0A914IF18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IF18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9636.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9636.t1"/>
        <property type="gene ID" value="Gr19_v10_g9636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9636.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9174" checksum="F77F9C3C6E73C3E6" modified="2023-02-22" version="1">MITAFTKIGAELKIPLQCVRHKRHNAGQRVLMQRVPWPTVPLLSEILPYDDAEGPRKIVLIRVIRQKQKCSVFLWPKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF89</accession>
    <name>A0A914IF89_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IF89"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9344.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9344.t1"/>
        <property type="gene ID" value="Gr19_v10_g9344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037271947" evidence="2">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9344.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20358" checksum="DC1CFA8C66BA33BE" modified="2023-02-22" version="1">MKRFFLLQLFEVSALIAYSNGETACTFKNYYEDWDDVSEEIVNVLCGGQNDAPHCFSAQCKATVRWRWSRIARAGCINHLGEQKCAENMERALANEEGGIWSCKCHILAGEISPNIVPTKSSVGPIPSDTATTTKNNNATTTLPYFEFREPIDLDNGRGFGIDLTVAVPTLLVCLAFAFGTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFM4</accession>
    <name>A0A914IFM4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Acyltransferase</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A914IFM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9435.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9435.t1"/>
        <property type="gene ID" value="Gr19_v10_g9435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9435.t1"/>
        </source>
    </evidence>
    <sequence length="439" mass="50498" checksum="E1FCB64DD2D76656" modified="2023-02-22" version="1">MDYTTTLCAVDTNPFQFHSGTSQRTASHKFEMDFAYTKCLHFRVRVVPFCCHGGQTFVYIYMNTVRMLLIYLLLAERTLATVFFRKYFELYGRLWLNIVCVIVLSSLSYAIQVTQKSSPHDFDDSTMISIILLFALQIFAIMIFMYIYLQNKANYKSNKVLTLNQRFQLSENIRTLKQLGPTFVLYTLTVVLIYGIKFLFIFGWVVNDAPTKIAFMFQTLLLSCVNIGIELTVITHHPMLKRKAIQLKKCAEIGTNFNYLFCVHPHGSCPCTSAIVFGSNGMISYDRESIKYVLSRPEKGNAVALVVGGNFISYFVNGLNQHFFSTYKVLFGWLLSTVRHLCPFTFLERQIFAIIRLYEESRNLKAFLSDGTRTFGLLPHRRRIVTVVGAPIEIEQNPEPSETYVSQVHAKYCFKLLELFNTHKTTVGGLEDDVELEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGF6</accession>
    <name>A0A914IGF6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9651.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9651.t1"/>
        <property type="gene ID" value="Gr19_v10_g9651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1109">
        <property type="entry name" value="COLLAGEN ALPHA-4(IV) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="786"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9651.t1"/>
        </source>
    </evidence>
    <sequence length="888" mass="94468" checksum="19C16A458E392A56" modified="2023-02-22" version="1">MASDYDEADYATCCQQNPKNPGFEHFVRPLTEVGDVQQRWSTSSSIRQQHSAGPAAAKRTTTTPPRQMVTTVLLNNGDTNKTPTVKMVGGQFKQQQQLVDEYLLDLPSSSSSSASVHSTTFVGTSSKPKLSCNSRKISFCRSRTTPNFERTTTKWRHQHNNNNRMPNLSKFVAQFLPSTECVHRVCPFLFLLLLALLLLQQHFYTEQLERRLSRLEQRWNNVAELLEVPPDFNIEHNAQQLRRTLRSLYDRRRPQRDGTRQHHQHTNNHQQTPKACLCPQGPRGDPGIQRRRRRLAAAAAEPCTRFPSGDAATPWRRMWPRLKRPTARLLQHQQSQRIRPIPLGSADHELRTFGFLYSADGRVLYLRGLPGLPGPIGPPGPKGDKGDQQPGPVPPPSFAESRYAAGYSEQGPTTNAHLNHKYHLHQPPRSHTAASSQQAPIVIQGPPGPPGPPGPPGRPLPGPKGERGLPGYDGESKTGPKGEPGQGGRPGPAGHGGDKGEKGSMGLPGRDGRIGQPGLVGPRGFPGTKGEPGAPPLGPYPSYASQNAGGGKHDMNADGNATTCQQPCRNGLPGRDGVPGAKGEPGVPGAPTVLAPVGMERSGTNAALLPGPPGPPGLKGEKGDLGLPGLPGTPGKKGRKHKHKQQQQQQQQQQQQQQQQHAFGEQALQHNQQQQQQQLVLLQQLLLPVLHEQLFRNLSRQLQPLLVGRTVHGPRGPPGLQGLPGHGGEKGERGDIGLPGLPGQPAPPATPSVFTGGGAAGPSKLVVPGPRGPPGLPGLPGPPGPQGRIGPPGTLGLPGLPGPMGLRGPPGAIGRSAVQGQKGDTGPVGPPGAKGDKGPKGDQGLPGLDAPCPPGPDGLPLPYCGDPAPLLENNNFVHNGNGLLVHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GNR7</accession>
    <name>A0A914GNR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g1003.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1003.t2"/>
        <property type="gene ID" value="Gr19_v10_g1003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1578"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1511"/>
            <end position="1520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1003.t2"/>
        </source>
    </evidence>
    <sequence length="1719" mass="177584" checksum="3DE8BFE6198EF0DC" modified="2023-02-22" version="1">MSTQFESIGRLDMPEEEAEAVQATVADIMAKTSGTEISDRPSSESNSSSNEQQKVPQQHQKQIEAVQKQKQQRHHQIGNGTVPTVPANNNPPSSSACSGRRSPSADSERSLRLVIAESGGGTSGAESSPLTTPKPMADCGGGGGGAPFPLSGAAAASNSTGVTVNRPPAVGGTLDMAQTSAIVQSNVEEPKENGQISKTAEPLKEAEVQKESLSPTGTEQMAAKSLKLDEKSAGDESADAAQPSTNRDFGPVTPPPPAAVNAPPSLSPSPTVPDVTLSSTMPSSFCGGPTIIPKSTATTSASSSTATVASSSSNNTIVTVSIAGKSAASINAAAAAAAAAAATRSTATAVNSSATGGGGGTSTTAPAPPTLALMRAPIQPTPVTRILPRPTAKKLQQPKLPQPQQQQKSMKPMPTTASTAASCSTSTLPTMAITGTMTAAAAAKQTGVKRVPSTTATGPTTIFTSAKTTTTSAAQPQQQTIFVSGATTNKFAAVLPQAHSMKESKDSTTNASSTSNSSNSSTPTSTTIADTVNRVAAGAEISPPPSQQQQNTTQAAAATTVLSSSTAATASNTTTTTNSTTTTTATKSMMIVGQQQGGGARVQQLLKPRPPKKKKTAAVAPKATLPAIGGEGNAAVDEDQRNASMSVVELQQQQQQPSSATSLFPVAAGAMPASNGPGGGGTMLFPPNFALAAAAAAAAPNGTVGGGLVAAPYPTGAGGGGITHYFIRQTTASGHQQLIPVIPSQQQFFFSMPAGTTEMVESNNAVNASTTFQGQTSSEGMAVQQQQQLRNVYFRSGNDLFMPAMVSNGGTVAANANANLLASPAVSTTTLSQNSVQQNFVPPPPLRPPSVQQQQQQQKGGVQSKGTSTTTAAARMPIAPKGGQAGGEAPSQPPSALIIGAPHQQLAPAHCPPPQQQQQQYFLTSTGAIVTLQAPPHHLQLQHAAQQALGGVRILPATSNNNNINSNSSATVATTSSAFTAGGTFVDFYQPSAQAPTMTEQYLHKNGAGAVASIAPNTARSAANSLTAKISSPKRKRKMDEKKIAPAAATSVRISTNADPTKQQPPHLSHQQQQHQMPDLNAVVDEEENEPPPVLCRVVNRSEEEPSVTTQTVESVFQREAKIIRERMFDANGKKFGPLKHFIDGFEIEEDIEPFACEHRQLLDRLKREQAGLEAEIEERSSSKAASLKSATISPEKITEDVIKRKGRKRAATASSCASSPERSPLPAPPSATEETVGSSSTTNQKTKQHRQQSHDATSATEANAGGTAHATATAAEAAAAVKKGRRRELDGLLKMDFGKHSPFQTSDPDKYAQDVLSSLALAQGVERSARPSVESSGGSTTGGGGAGGGGKSSKRDKHAKKPFSPPVSPLPESRSASAQSATATTTTTTAQKVRTGGEKASPSKPVSTANGGAGQPTKGTTLMPSGDNKLKTSPKDQRRSDGSNASEEGEERCLYCRRSFKEVPKDKDHVQYCSKACRKQLKAAKRMKHSGSLEDGLNNSGGMAGDESRSGNSAVSATTSHRRSDPSLSSDSSGQQQHNHITSPLGSAFSAMQPQLLSKRRLPVDQHAEQLMSMNQRLSGGSGAGMIAPFPPPPFGQSSPDQPPAMLAVPMAIRPAPGTPVPSPALIQYGTPTAMYFNAAHQMAVSSSAEQQQQQAAVAHAYHQQQHMLAKRNISRNPNTVSLFFCAVAAVAEHSRWPLIFFSDASVNTDSVHGQSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GP12</accession>
    <name>A0A914GP12_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10099.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10099.t1"/>
        <property type="gene ID" value="Gr19_v10_g10099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="267"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10099.t1"/>
        </source>
    </evidence>
    <sequence length="1370" mass="149358" checksum="89DC3181D4FECFF1" modified="2023-02-22" version="1">MHPAASANQQQQQHHYFQAVLPSAFPQVQLAPQPAAAAAAVASVSAAAGHGPTANWVRLAALAAPGSSAAAAAVHPAFLDPNLVVHLRSGLCTSHRQAQPPAQMMMAGRMPPPPPPTYVPQAGKAAAAMPTIYTAPTRAYAQLVAMPPHVHAVHAHQHCHQSSASAAQPPPPPHVMLPTAAVPVPATTAAFVGGGCPPAGTSMASGHNRLLPPAISGGGGGGTPEGAENGNNKNCTGGGDCWSTAVTGWEQAAIIKNKIGLLINGRFRILQSIASGSYGEIFAAEDLQHRRHRVAVKFDGACRDNHLRYEYQVYKSALYEDGNGKVDGFPQVYWYGHEYGHNILVMELLGAPVASLFAFCDRKFARQTIVSLGEQMIHRIRHLHQRGFIHRDIKPENFLMGLAGKESTLYLIDFGLARRYRYRENRALTHIPFRRGRNFIGTAKYASLNSHKNIELSRRDDLESLAYVLIELVNGHLPWKNISKRNATTRHQASQRIRTLKDQTNWDEFCPPMAKFIKYCREIPFNEEPDYDRLLDLLQLITVLLPEYNSSSISCFGPYAAPAVAARCRAEKKLTPMALPAAVPSAAAAAAIMSRAVCCQTPETAEKMTQVDFETAKMYANEAEQKMAREAQIVTEEDTETVSVTRVVASTMQRLSMKVAAENGTGSDIEEVGAATTTTSCSDNELLLDSGGGGGCMTGRGGESSATGELRSVVGTAVSDGDDELTADSQPTPQQCRRLRDQQNQQQKRSQQQQQQQQRAVSPPPQPTNRVEQSLQTEALLLMPPHKMCWQQARDSNPERRFQYENRFSWTVDKQQQHQQGGMIMTTGPVVDEHHHQQQQYQQHVQAVHHLQQQQQQHAQAVQLQQQHQQQQLAAQYKLRAGAALPIGVPQLPPQFVHHLHQQQQQHYVAPPQFLLQQQANCPNGQIPPAHHPFGIVVPNSGIASAAAPVPFQTQATAAAAAAAVQAVAATQPPQQHHHHQVHNQQLLPAAVAAQFVMPPPQPPPVLSECQQIQMAKFGANLNRPLQQPPPAPVTVVAPPMQQRQQQQPQQQQQQQEQQQQQQRRFMHIAFVLPPPSPAVVDVPPPPVPRAMLAPAGKQNELSSDCSSTGVPDPSPPRPPPVVGRNKHPQQMFPTFRFALLLAIVLVLLSLCSTTPLAAHVHPVQQYAGFPETVAVPAPPVPYKPLSAAQRAALAPAHPAPKATLQQEMLQRRRMVAKRGCCCCCCKPCCCCCCKPCCCCCCKPCCCCNCCNNCCCCCHKCMCICVRPSCCCKCCPTCCGCPGYGCGCRRRRRRALTAPVGYPMPMFMQQQIRAPTFAPGLCRELGHVRMLSERSHSIGEMHANVNLVAVDDQQRLAAADMAAATRNEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPM2</accession>
    <name>A0A914GPM2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GPM2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1000.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1000.t2"/>
        <property type="gene ID" value="Gr19_v10_g1000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="128"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="491"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="599"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1000.t2"/>
        </source>
    </evidence>
    <sequence length="801" mass="86570" checksum="3EBA7A4385D33F5E" modified="2023-02-22" version="1">MTDCPTKSDCDSNTSTTDTERREIVGLFPKLDLTEVFTEYGHLSSGAIIDLILEKQHQIPCKRGTACSFAIGVSAWWPRWLGGRVFRIMLSSIKAKVTGVPSVKECMECTVCWESATVEELCFCDGTTTVTSSTSSSSNDGQQNTIVTLSNETHAFCRQCLERHALATVEEMPLAKGGLGLRCMVNDCENPITFQEIQTFMSPSMVQRLEERCAELSVVQANLSYMERCRSCNCAVELGASPAVLQVFRCPECRLQFCRLCDEEWQDEHKGISCEQFGKQQNRERLLEKRLSEAVVRNCLKCKVAFVKHDGCNRVTCRCGANQCYICRENDIDYDHFCRCFREKIPPKLPFKCSKCGKGCLLWQRAEPVEKQQMERIRREMEEEEKAKAKKRLGTGTAAPTSSTSSSSRIPVKNKGKVVVAEKPCKTNGKESQEKRRLPPELLHEVFLALPYQANRQLLLLRNPTVYHRASVQRQRRRNIDALVTRGVLTWTVEEVSRWVNFVTRSDSNGDRFVEEEIDGSALILLDEKTLSNNLNFLPGTAIELWSALVKLKLKHIDDLELKRKYATDWSWFHLAQNVEFIRRTMKKEEKAKTKEQVGTGTAASTSSTNSSSLGTGTAASTSSTNSSSLGTGTAASTSSTNSSSLGTGTAASTSSTNSSSLGTGTAASTSSTNSSSLGTGTAASTSSTNSSSLGTGTAASTSSTNSSSLGTGTAASTSSTNSSSLGTGTAASTSSTSSSSLGTGDSAGTSTSSTNSSSFGTGTAAPTSSTSSSSRIPVKNKGKVVVAEKPCKTNGKVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQW4</accession>
    <name>A0A914GQW4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exocyst complex component Sec5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g10479.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10479.t1"/>
        <property type="gene ID" value="Gr19_v10_g10479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000196">
        <property type="entry name" value="Exocyst complex component 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2086"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="19">
        <location>
            <begin position="1241"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1383"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1431"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1600"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1731"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1906"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2166"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2222"/>
            <end position="2234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2244"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1408"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1451"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1608"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1627"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1756"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1932"/>
            <end position="1941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10479.t1"/>
        </source>
    </evidence>
    <sequence length="2303" mass="254287" checksum="A03EC9FA3A480D45" modified="2023-02-22" version="1">MGNNQGGFHKRERTGDGSQRRATGGGTIQILSSSSSSTGSHQNPLHGHPSSGADDGCPVQMKIAKPDLMSEDYVDFGHNEYPVVFKWHSEVQPAKHVYLTGSWDCWHKKIPLVKSSSDFSTIINLNPGLYEYKFLVDGKWMVDDAITKTDNQMGSQNNVMSIDKADFAVFDALDKDLASSNAGEAMRSMNSTGAAQPSQDTPNDRELERLREFTQQLPDRRDFEKATNPPILPPHLLQVILNKDTPVQCDPNVLPEPNHVMLNHLYALSIKDGVMVLSATHRHRLNQKYLSTQDNVDKEFAFTFCQILMSAPAAISLRANAPLVTGISPHQGSPGTLVTIRGERLGEDANDLVALIICGTDCLATAKWKSSSKIVARLGGQAKRGPGDIVIVTRLGGRGQSAVQFRVFIEQIGPLQESSVWVDESKTVPGRNLIRNVQESGDPEDVLGLGIDQQTKMDDAGLSRLFPEGTGSRKMENFSPAWHLLENYKSASVTDLKRGMANLEKRIAREEECSKNLHKANLFLLISCVDALTSLHSQIQAKAISEDWPITAKVTGKIDLAAKMADRLFRDVLTRKDHADSTRNALSMLTRFRFIFFLAESIEANMTKGEFATILNDYARAKALFKDTEVNLFKEVMAVLDEKIGQLRECIRSKLLDISTPFEEQSRLIKFLKILDPESDPAWDCMMSYHGWLENMLWELQIQFQTKSIEAQERAYEYKPPQHFRQAFVVDLLGLLTEKLQTFWKISQNFAVTGPTTSAGASTLSSTEVQQFQERQMDIDQMLTNTINVGSWLLLNALVPDALPESVNRQYKDRFAKWPRLGSNAQWEVMFPSIKTLRASIKTLAECLNRSHLQPLTELCTTIRLKCLGMLVERGKEAVLLLGAQENWRVDLMADPPRTALPDLFETEINELISDVKERWRQMIIDLFTVLLLGVRDCYDFLLKLRREQKRPNTLLDIGSFGSADEDGNRMSKQPQEQASRRFLVAIANIDYLINRSVSGICRRLSDNGVKFADQIFKRTKDKLVAYRLTLLGHYTAQKLSQVQSILDTANYTHLPDEDDVSDFVKELMLCAVFVQAEMAPFCAHFTEQVLADIVKVSLEQLFAELSRVDLSSTERSTQTIVDLTAFEKAFQEFITTDMRSALKSIRARLMPRLDNETFRNSMLNFRSGMTMAMEIICSHIYLYGQQTNISNPLQTTLLAMISQFLPKLSVMPLTFLLVLLTGIFVPPVDGFSQPEVDLHGPNVCTFEEEREKIVIKKYDRQVQLVTTQWCPDISKGFQCEVTVVITRCCKGYFQGHDDICEPICDPSCKKGDCVEPNKCKCFDGYGGDTCSVRCPLGSWGPNCRRTCDCEQTKNCDFVTGQCRCPAGFMGARCEEECPNGHFGDGCKSQCLCQNDGICDKTTGECSCQPGWSGKHCTHRCEKSHLEEGCRYECNCANGGECNDKTGECTCLDGFSGELCEEKCKDGFFGPGCKKRCDCLNENICDPKTGKCECVGFTGPRCRTPCQRGTYGLECSKSCNCDSEAKCERFNGSCICSEGFRGEHCSEKICPFDRFGLRCEQTCACNSNNTKLCHPLNGFCTCKPGFMGAGCNSVCPQYYYGDLCAQKCKCAFENGATCDPTDGKCICPPGYTGKRCDQKCPSGFYGIQCESKCNCQNDGQCDFRYGTCNCTDGWRGPSCSLTCWGQTFGHKCQSNCGCRNGAGCDPLTGKCHCGTGWTGEKCDQPCAAMTFGIDCKQKCQCENGGTCDRFSGKCSCPEGWTGENCDSHCDSNKWGGQCENECDCSGFGSCDQHTGRCICQDGRVGTNCAEVCPAERFGKGCQYQCEKCGHGQTCDPATGVCLICAAGRSGFKCEQNCPKGFWGVGCSEKCFCDADGGSCNSIGGTCECALGFTSKYCDQKCPAETWGFNCSQKCRHCLNGGLCSAFDGECKCPPGFEGELCQRRCSEGMWGVSCMNNCTCRSDRKICDAATGLCECASGLKGDTCDEYCDAGFWGPDCVKKCSCREETSTCQSVTGQCLCNPGYLGKRCEKTCPSGTYGRECKQTCSKCPEGQICDPVVGCCSPNLGHCGIAYAEQQGIQRSISSYFWSGLLLLLALSVALIGFALYYRRKYQKARDPPLPTVSYNGGDYASVNGANSNGTGTEPKNQFENRLFDEPDMEDNLAINPQKEKALFRNVPTRPENEYATLDGPDEDFGYAEAGNGTDGRPSSSSVDGMRRSSPRRQGSDGTSTQHIGTLRLPGQATPPSTALINPTNHGRPVGDGSTRTSFDALDDHNYEEPVLMLNTSKQIAADNAKGGGNIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRV6</accession>
    <name>A0A914GRV6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRV6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10819.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10819.t1"/>
        <property type="gene ID" value="Gr19_v10_g10819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037355469" evidence="2">
        <location>
            <begin position="18"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10819.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23470" checksum="84EF4A29F02661E3" modified="2023-02-22" version="1">MKLNILQLICLINYVVTFPDELFDELWETNQSEPQANNNPIEPKPKIKVESNEEQFDRDEPAIKGMVNEHEPHYGAVKMEGKVKHEFEWWNEESREFKEQLEDHVKEEDQDGQAPNTFGHKKIGDDDENLEEDDNKFIEETDQDEQQNDSNEWYTVEIPFNEETTREQRIKAKFALPIINCSSTNAQFFCDFLIEFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTC4</accession>
    <name>A0A914GTC4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTC4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1118.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1118.t1"/>
        <property type="gene ID" value="Gr19_v10_g1118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF241">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1118.t1"/>
        </source>
    </evidence>
    <sequence length="400" mass="41536" checksum="CB422BABEFD2F93A" modified="2023-02-22" version="1">MHNCTIICPFHRRVRHFLPSNRWGEAANPHSTHSPGEQQIARRPRACPTALQKSEGNTLKRRMQKQLQVSSTASAQQLQPLPSCPRGCTFVIHKVESEAREAAYRFVVYTAVSFSLAAIVAVFITLPLANQYITSVQQRVQHDMDLCKLSAKEVMVEMSEMRMTEDDLPPTLSMMGRANAEGNGTRFRRQPREPRKQCEGCCTPGLPGPPGAPGNNGVPGRPGASGAPGFPGRPPSTCEQVTQPPCLTCPAGEPGPPGAPGDQGNMGPLGHPGRPGNDGSPGPQGPPGAQGEPGEKGRDGSRGDPGRPAISTPAQPGDPGPSGEPGPSGIPGEAGEPGRPGNDGLPGPQGAPGAPGPAGPPGQSGEDGQPGHQGPPGERGICPKYCALDGGVFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTN9</accession>
    <name>A0A914GTN9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTN9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1031.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1031.t1"/>
        <property type="gene ID" value="Gr19_v10_g1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1031.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12862" checksum="2BD0B610358D2F05" modified="2023-02-22" version="1">MFCCGLLDKSELPASLASVLPADVVARINTLLSNKSLSREQKAQQIDDILKTVPDEVLEKLPEPPHFAQLPTEVKDHLKQMRRDCKHKSIAGKKEAFKAYLGTLPPEQQAILMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU94</accession>
    <name>A0A914GU94_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU94"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10459.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10459.t1"/>
        <property type="gene ID" value="Gr19_v10_g10459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10459.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9851" checksum="51F91BD0F87BD6BF" modified="2023-02-22" version="1">MSERASGRTTKAAEEGIWIEETDEWLDWWTTNIKLLIPEGDGRTKGKCSETPQGDSLYSLLTCAPGDDCESKAHDNPYTPIVPTGYWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWK3</accession>
    <name>A0A914GWK3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWK3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11416.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11416.t1"/>
        <property type="gene ID" value="Gr19_v10_g11416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="787"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="886"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11416.t1"/>
        </source>
    </evidence>
    <sequence length="952" mass="109555" checksum="A6E8817B930FDB90" modified="2023-02-22" version="1">MYSIWDSIWLGGMYSYLGQYLVGRDVHSIWDSIWLGGMYRTLGQYLVGRDVQYLGQYLVGRDVQYWDSIWLGGMYSIWDIILVVAGCTVFGTVFGWAGCTRIWDSIWLGGMYSIWDSIWLGGMGQYLVGRDVQYLGQYLVGRDVQYLGQYLVGRDVQYLDSIWLGGMYSSWDSIWLGGDVQYLGQYLVGRDVQYLGQYLVAGCTAIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYIIWDSIWLGGMYIIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMIQYLGQYLVGGMYSIWDSIWLGGMYSIWDSIWLGGMYIIWDSICWAGCTVFWDSIWLGGCTVFGTVLVGRDVQYLGQYLVGRDVQYSGTVFGWRDVQYLGQYLVGRMYSIGTVFVFGTSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYSIWGQYLVGRDVQYLGHYWLGGMYSIWDSIWLGGMYSYLATVFGWAGCTSYLGHYWLGGMYIIWDSIWLGGMYIILGQYLVGRDVHYLGHIIWLGGMYSIWDSIWLGGMYQYLGQYLVGRDVPYLGQYLVGRDVQYLGQYLVGRDVQLFGQYLVGRDVQYLGQYLVGRDVPIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWLGGMYSIWDSIWWGGMYSIWDSIWLAGCTYLGRMCGRMYSIFGQYLLGRDVQLSGTVFGWAGLLQYSGTVIWLGGIVQYLGQYLVGRDVQFLGQYLVGGMYISWDSIWLGGMYIIWGQYLVGRDVQYSGTVFGWGGMYSLGTVFGWVDSTVIWGQIWLGGMYVFGHYLVGRDYSFLGQYLVGGYTYLGQYLVGGMLQYLGTVFGWADVHYLGHYLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWW4</accession>
    <name>A0A914GWW4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWW4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11941.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11941.t1"/>
        <property type="gene ID" value="Gr19_v10_g11941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11941.t1"/>
        </source>
    </evidence>
    <sequence length="525" mass="57099" checksum="45366442BDCD8E59" modified="2023-02-22" version="1">MLSAKLSPPENGPLASRTRFMLLVLVVLCLMINWANILTFNFTVICMRPRGNQSEGHHDQHASTSANSSTTASPSTNGALTHEFTNNEKSQAMAVVAAGALVSNIPIITLINWYGPRYLFTVVGLFGAAATAFIPYAMQLGWGWFLGVRVLQGMAFAGDMATFGHFVTYWTYHKQYAFFTATLCVYVQLAPILTNPVSGILCESSVGWPGVYYFHAIVSAVLFVLFFFCYRNDPNKHPFVNDAEKEKIARGRDSQNAKAQMHVPYKEIFCSPAVWAVFFGGVGNFTGINLLYQFTPTYLYKVQGFEVIKTGFMAALPPLGQALMKECAGLINDRIPARIMSETTKTKVFNSIAFLSMSTIIVAVSFVPSGHGNLALFLLTFSAFTLGFNVGGFYKSGSMIAGPYSPFVMGQISTAMTVTMLTVPVIVNPLTPNNTREEWALAFYVNAAIIVACNIFYVCFASAEIQPWATVENYNERMAKKQKPPNGGTAARVYAVANGVSAADTEMDTAAGKGRLGSEAPVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXR2</accession>
    <name>A0A914GXR2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXR2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12160.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12160.t1"/>
        <property type="gene ID" value="Gr19_v10_g12160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12160.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12946" checksum="C87D5C503158B9C5" modified="2023-02-22" version="1">MDKCNESDRREKGDATDSVPRPRYELARWLFIHPNSGNGNGTTWPCSYALNYTPLQDEASVDAHASGHGQLPYFGRLLWNQLGCPLRPLRSYKHMPMPRTIPPDGPLRKRLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYQ0</accession>
    <name>A0A914GYQ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYQ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12418.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12418.t1"/>
        <property type="gene ID" value="Gr19_v10_g12418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF54">
        <property type="entry name" value="CLC-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12418.t1"/>
        </source>
    </evidence>
    <sequence length="651" mass="70631" checksum="3B501D18800D5E19" modified="2023-02-22" version="1">MVKTSSLQAGRFELCFSAFFSTFVQELFKLYVLLRQCASGKRIERVAIVLIASGHTTSNLSSALGPLCCDVSAGGEMTKTYKEQEVDMAFFHRLPFPLNLLLLLMLLVPHVHPFALRFRRAAPGLPPDAPLPPPGAFPGTAMEIAEMRASLPALPPPLPSSAIAPVLRPPSGTSFPWGAIPDPPSAPPPPPPPVSTLDEFNGDPPVPPPPQPPPPPPPPPPPPPPLPPHPSFFKKKYGGYGYQKFGGPPPYAVPPPPPPPLPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPLQSLGPPPLPPPPPPPLPPPPPPPPYGAKPYAVMKKSWIEHSGEFLPVDLPWPSKFNRTSPWALGSKHLSSSSGNFAPNQMASGGPLVPLSLLQIVALTLALVGVVLGFVAVLTPAWQVVYAREIEQWVQSGLWLNCQTRPNGMYTCAYVFTNSDFNFYTSTELLNMRAPPFYAWQRHVLFVYLGAQLVVFLSLFSLCLSFHAPTRRLSAISFVALMGVAVLIHTGATLSFAVLSQMVEYRFFHVSVSGIYEKHRGYSFYVECAAIVLLFFSLVPALFHLFRLSRADMSLGHRFPSKLQYARGTSPPPLFTRDTSDEQQHWEARFAMRELPPLPPVAGFRWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ18</accession>
    <name>A0A914GZ18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11716.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11716.t1"/>
        <property type="gene ID" value="Gr19_v10_g11716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="376"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11716.t1"/>
        </source>
    </evidence>
    <sequence length="905" mass="104852" checksum="9ABABBCF0DE41E4F" modified="2023-02-22" version="1">MNGFGCAELTPMPEQSVPMPDMAEMTFQDCVRKLKKLNEETSRAFDAMAKLDAIQSTMRAYFDFEDVGDVFEGFLNLIRFLKSLITQQFDTSLVKLALITFDEFQKHRMAAEHHQPVPFVLPGDHTLLTDAVEQCFRLKAKHIDVVCSVFRLKDKQMMEIAIKRIGELVPNDLAKAVAWMAHLNLRDHFNFNEIVCRLILDNQTALLYPFVGDEEYRRTSRVTNELEQKVIINCKQLEKITRKFATNFGMDVPNLRKLRTQNALLYNHHRWRHGEISWNQFEEFARDAMLHCEDVRDRYFRRLFVDFNLPDQACHFAELLEVREEHYIPELKWFYQQNAGKVDNIRKEIRRSIAVRKQNQQLEEQYVCELYKGYQIEVIDRWERLDRLIAHLRHGGEELFGIDAEWCPHFLSATATERISLIQIATTKAVFLVDVLLLDTEGKMTESHWLNFFDALFCTDGPRKIGYDFRNDMRVLRSTFPFIDKLFPLVKEVVCMYRLLSKVKLYPEASSAVFDRTDVECPTHLSLSDVSAYFLDIKLEKTEREGNWSIRPLRLEQKKYAAFDAYCLERLFRKVAEKLKTLKNKELANALKQHSLINFVDAQPAKSSAIIPLVSGQMVRIKEGEEDFILNVQKAAREIEHAAHGNLHGFRSIREVRFIADSMLFGLGKHLRKCGFDARMIGERDQIIEFCKQSQNDGFVVLSTGKAYTQLQLQLHGSSHEVVCVPMATDGTTPPSLIVKYLLHELRILLRPEDMWSRCVECNKRAFVRLPKRVAQTLCYMNAVRHGADWLDISAQDLKHCVNQLKAESVPFSADQDDNYEAQQRLLDAEADEYILVEDQTNEICLCRNFSVNMLNCLVLADQCSAPVKVRVGLKFKKDTFDMAGIKFYACTECGRLQLNSASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ35</accession>
    <name>A0A914GZ35_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ35"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12446.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12446.t1"/>
        <property type="gene ID" value="Gr19_v10_g12446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12446.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26789" checksum="FE9B7777EC2A778A" modified="2023-02-22" version="1">MSFIFCRANRFHGTEKEKKGREKFFIISRSAGIDDAQSANAVILWERKFLLRNLAIFQMKIFSKLLQEPWLLLFGLFQLILTALGALHVRRSFSPFFSSPKLLLLLVLLALYALFATASAIFERVRHCSVRQQQKQRLPQTHRLRPLLFVTVGIILVRCLSSVSRHFLSFHFDGICSAFGAFESASLFSIVLSLLITASIPLRALLHRQLAELRQDALWARLIGRNCWICVEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0B7</accession>
    <name>A0A914H0B7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0B7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12446.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12446.t2"/>
        <property type="gene ID" value="Gr19_v10_g12446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12446.t2"/>
        </source>
    </evidence>
    <sequence length="243" mass="27772" checksum="7109C0F50093C179" modified="2023-02-22" version="1">MSFIFCRANRFHGTEKEKKGREKFFIISRSAGIDDAQSANAVILWERKFLLRNLAIFQMKIFSKLLQEPWLLLFGLFQLILTALGALHVRRSFSPFFSSPKLLLLLVLLALYALFATASAIFERVRHCSVRQQQKQRLPQTHRLRPLLFVTSTVSVFGVPTLFVLPYFCRHFSPLTLPLDFDGICSAFGAFESASLFSIVLSLLITASIPLRALLHRQLAELRQDALWARLIGRNCWICVEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0C6</accession>
    <name>A0A914H0C6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0C6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12453.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12453.t2"/>
        <property type="gene ID" value="Gr19_v10_g12453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12453.t2"/>
        </source>
    </evidence>
    <sequence length="487" mass="54513" checksum="E892A6AAEA9B927F" modified="2023-02-22" version="1">MKKKKGPSKLSAAKRSRSSNSSLLTDEDMEHSDGVPETLSDLTVPADQSAPIPEAIRAVDELLDSEVAKRIRTENEVTIRFCCPLYANVGTVEQTSFCLDDSLLKCVPPNASSDRRADVARLCPFDLLFLCRPQSRFRCALFERLRLKAVASGGNAIPYSNFVFTICYAFQISPSSLLFSNGGIAHCQQTNLFEQKLDKIASTWAPLSIRDDQKRLCLRYANIDLLLKVWHYLRFEHWTDRQLVSLCRAMARLYLDVGAREFRGQITRALQMTFSQLSPSGRVRTVLSQFLTSSLLLSADHCAHKAFDVFQMLSQLDHFEHSLRLLAMQIVLKSIISKGKAERSNLSLAAAPVNLGDVLAHLPAAVSVLSSSAENEFGKTSEETNGETIFSLASTVVYLACNRWVDAITADDRVLLSTRDESEASLEEALQRIRQTNGQLNRRNINDKMVQTWAQSEHRIREALSNRQRGQLRFVGSSSEDDDDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1S3</accession>
    <name>A0A914H1S3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1S3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13214.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13214.t1"/>
        <property type="gene ID" value="Gr19_v10_g13214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13214.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10765" checksum="EA418B4B19CC7F1F" modified="2023-02-22" version="1">MAQAKEEAFAIRYPSNSTKSKRERRPISSIQRFAFYVHPNKIISSRNLFQFAQRTSTTDDSFSFAQLTRKNRTPKRRLEAGYDLQRSAAGSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H265</accession>
    <name>A0A914H265_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methylenetetrahydrofolate reductase (NAD(P)H)</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H265"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12985.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12985.t1"/>
        <property type="gene ID" value="Gr19_v10_g12985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12985.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39301" checksum="090602898B58D419" modified="2023-02-22" version="1">MLASLINDRHRQQGQCSPFFSLEFYPPLKDQPKNMSDFFDMLNYLKQAQPLFVDITWSRRNDPGNLCKLNSSSAIAIATADIFGKERTMLHICCNDHTKAESVSHVEQTLGHGIPNIMALRGDDLPEVTPTLNGQLLNTKHYATELVKWTRQLEGVRGICGDNRLTVAVAGHIFSPIKTVSYGQCMEYLKAKVDAGADFIVTQFFLDANLFEQFRADCRSIGISVPILPGILLFKSAASLRKIAELSNVPIPQQISQTLKQIGSDTVAVQNYAVQLAYDMCRNIFSAGHTTGIHIFTLNQRDMCGKLLKRLGFWPTMNLEISAKLNDNDETNIIKKEHLKISLNGTPTRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H380</accession>
    <name>A0A914H380_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13436.t3">
        <property type="protein sequence ID" value="Gr19_v10_g13436.t3"/>
        <property type="gene ID" value="Gr19_v10_g13436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23278">
        <property type="entry name" value="beta-trefoil_MIR_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000006">
        <property type="entry name" value="Protein CBR-LIPL-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000132">
        <property type="entry name" value="Ryanodine receptor 44F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000017">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000003">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000022">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035764">
        <property type="entry name" value="SPRY2_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5076"/>
            <end position="5098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5216"/>
            <end position="5238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5258"/>
            <end position="5282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5342"/>
            <end position="5361"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="19">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="587"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1021"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1526"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="4479"/>
            <end position="4514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1330"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1422"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1499"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2670"/>
            <end position="2693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="4788"/>
            <end position="4811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="4842"/>
            <end position="4915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1343"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1422"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1445"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2682"/>
            <end position="2693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="4876"/>
            <end position="4887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="4901"/>
            <end position="4914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13436.t3"/>
        </source>
    </evidence>
    <sequence length="5463" mass="618046" checksum="C2CE0B96246F7661" modified="2023-02-22" version="1">[encoded data, 5463 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H499</accession>
    <name>A0A914H499_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine kinase/Phosphomethylpyrimidine kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H499"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13710.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13710.t1"/>
        <property type="gene ID" value="Gr19_v10_g13710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13710.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="27339" checksum="9EF083095428C059" modified="2023-02-22" version="1">MSARRPIVLSIAGSDPSGGAGIQTDLKTFVALDSDGMAAITMLTAQSPQAGVRAVHVPPSDFLSEQLNALFEDRDNCAVDAIKIGALGNVANVRAVSEALCRWKPTKNIVLDPVIVATAGGHTLLETEAMKALLDELVPICAVWTPNLPEAAMFLGTQQAKDVTEMQRQCCELAKLGAKAVLLKGGHLSNSDACTDILLEADGAERFFGTKRLKVSAKNAHGTGCRLSSAIAVYLARGHGLGEAIQYAKRYVEQQISAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5B6</accession>
    <name>A0A914H5B6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5B6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g143.t2">
        <property type="protein sequence ID" value="Gr19_v10_g143.t2"/>
        <property type="gene ID" value="Gr19_v10_g143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF62">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="466"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g143.t2"/>
        </source>
    </evidence>
    <sequence length="687" mass="78349" checksum="698E6829CB57A1AD" modified="2023-02-22" version="1">MFAIIHLYKRYYKLGRYKVFDRFLSKSDASKKRNSEKAHVDSAFVRRLLRILRILIPGPFSMELFFMALIALSLLLRTYADVWMIQTSTKIEAAIISRNKPRFWKSLANYFLCMPLVSVINSFLKLSLCELKLRFRERLTHHFYAQYLNGFTFYKMTNLDNRIANADQLLTQDVDRFCEGIVELYSNLSKPLVDVLLYVNRIGASIGWQAPLQLFVYLLFSGTALTYLRRPIGRMTVMEQQLEGDFRFVNSRLIVNSEEIAFYQGNERERVSVLNAFQRMITHLRSLVLFRFSIAFMDNIVAKYVATVVGWSTLSRPYFNEHNEGMMRKNKTELMQAYYTTGRMMVKLADALGRLALAGREMTRLAGFTARVDQLMSVLDDLEQGNYKRTMVGTEQNGGTKQLAANGSGDGAQTLAIGNDATAFLSAEEDATLAQAAKDDDADGALSQSSTFRPGTGHILVQDNLIRFQRVPLVTPNGDLLIRSLDFEVPSGTNVLVCGPNGCGKSSLFRVLGELWPLWGGTMIKPAKGKLFYVPQRPYMTIGTLRDQVIYPDRPAEMRRRGFTDGALEALLEHVQLRNILDREGGWEGQQDWMDVLSGGEKQRIAMARLFYHSPQFAILDECTSAVSADVEDAIYRRCHELGITLFTVSHRKSLWKHHDFSLHMDGRGHYEFKRINHDNPDEQFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5U6</accession>
    <name>A0A914H5U6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5U6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13494.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13494.t1"/>
        <property type="gene ID" value="Gr19_v10_g13494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13494.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="25831" checksum="F5163C2BFFE574F7" modified="2023-02-22" version="1">MNCSAAEVCQFASHGRKFIIETLSADSDRADVYAFMQNIFRTNEPITCAIQSSALDTSQIFANICADCFQYDLSLVAKDTDGGTLIAICLNTLCEFDEQKEYTEEPADNKREFGEEIRNGPYTSKNANRLAVYIDWVERNVGFLSPETIRRAMKLEILAVHPAYARLGLASHLLRSSVQLALSSGCSHLITCATAVASQNFLASNPSKRSFFALSSTTECQFLSESMTTGKEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H756</accession>
    <name>A0A914H756_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13844.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13844.t1"/>
        <property type="gene ID" value="Gr19_v10_g13844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1829"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1829"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13844.t1"/>
        </source>
    </evidence>
    <sequence length="1911" mass="219154" checksum="0580370A02B3F9D1" modified="2023-02-22" version="1">MFPPILTNRTLNSTNLSTIDKSQCSLSPKDATTSNIDTELMADLNAAEQMLSVQAAKKQNKFFFTCPDIQREQSPERSDYSDYVDDDWSSIEDGENPRASREAQEAEIEDKYRSALNFLEEGNAERAVSIFSTLLLHPIMTKYHIPDWSAYDWKRAIADTPQKIVPNMAKLFFNINLAMIGLVEDPLQFYVQALSIRPDFKDLWFNCGQFAISRRDWRSAEFCMTQCEDEFRALEALSLIRYLNNDYFKCTAVLQRVFESCPEHQTGHVIRQLISESSPFWTECHSKLFSRDISEFCVEKLQKDKILRNFETFQRECIRPDDKCSSLFFQRVTSSLPSWAPLTIKIKTEINLRSNASSSNLKKTASPFLSWMSKCRSWAVSKGAANFPEQIALTEDSDGRAEGEAGNRAQIVFQDACVDQEVTNCNKNTKMPQAEIIDNEPETQDELSLRRSMRLIDDLNYFGNSLQPRPDDALNRQFNALTLMGFEDNDLEEQQIALSNHRHTVHFKSDSISTKETTKYPNTLRSFLGWVAFEQDPFMVLTLEEAEAFREVYVRWSGLCLGICPNATADLAVHQLAAELGSHRALSILQAFYGRRFLKRQKTFSNLFADGEEEIVGKSHLADSFRGTTMQFAQKSLNADNDVFRWVFDRIHSEQQQLRRGESDRPTVIERNEEINANSDESQQSMDCPNSSTVRRQLEVRYKWLIANLLPEELCLPNSEAFHFIHAFSELNSALGLMEPHWTLWSHAEFDIGCLTARNLKEVLRKRVRKFQLQQIDYLIETKRYEELKNVLLHQYDWASDSDDAHIKQMFLVIQCIRETDNSLTEIGLWISKILNEICRDDISDVLAKRSLRRCIHLLDELFPAGLIDRNLATESFFAAVGYYLGKLVQPALYEKSAQCSDLWRWCSKIAKFREGQLNVSELKAFYACDSALLDRRHPTKTTMLLAKGHEVLGKMKKCSRKEGMFLRLLIDEFLNTIRDPSVRLVLALPEYSDIRENVVSEIVQCLRCCLSDKFAQSRVRSNRIADHGSKLQWPVDRDFATKVLELILPPKLPEICSDIRVPSDFADLLIKAFDHLLEVDETQLRCLDEMLQSPFRLELEEKFDSDGLCCGYEERLQMSEEGKVRLENLTKIGNAEGEANTFSEFSAKCVYLLAYFHYRTGSGSGEEWLRKCLAIGGRHLPPNILASAWYALGRSLTYSYAIKNDEELLDKVEAYVFPFRMALFLHWEFAESHLDVGTIIYQLRTRFARFKVQRDVSKELRCKTQQKVEGMLQKCKVHFRLALHFNDSPKDVAWLSNYFLAKIAEKLGDPPETVLDLYYRCALALEEEGIQYLTKINRIKQTYFEPLEIHYKVHAYAHRYLGILNSPSFPPRTSFQCAKDLSTIHVYLKLFQHHGVQRRSMEDAHWSDAGFYEQPNLPKTWDRLLQPKSFKNNDVLRENVLSDDVEGEVADLIGSLVCASDLYFDIVRMCQTAFNVILQRFPHYKAFYRVARAFFDEKNFARCADILFDRLFLTGRKQKCNNFLENIVEIKRSDFERNGSFPYHLCKIVKLAVVASFKYDNIGRLKDLVVALTSYKPSSTSREILGEPLVKELLGMASRGFKSLAEKQQKLYGHDMQQLGKLIEQIEGVIGKLKKDGRCQKERSALETTLIACIQRRDKMSQRSDGHGIDLLESAAEVINVQQLNRLSSLTCRSHHTRKQQQFTAKLPIGLRATTLNASLSAEQNVAKSSVFSNAAPTQRQTHPLTMNSLASSSNLLQEQPTLPNSTAIHQSQNTNQKRLKPLDAEGFKMLHKILPSLGLNRIGLGMADKLRILQALFERLGYEFPKEKAAETSRIHEGGHSGKDNSLPVMQLQTSECGPSKSKDPPPLPIRPPAQRMTGLPPNAKSKNKTTKNNLDSSVCFNDYLRTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7M4</accession>
    <name>A0A914H7M4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H7M4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14766.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14766.t1"/>
        <property type="gene ID" value="Gr19_v10_g14766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14766.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18638" checksum="2F85E290564AA915" modified="2023-02-22" version="1">MRFSRDQLNMLERAFQKTHYPDCFERENLGAGIGVAEWQLTRWFQNRRAKDRRIYKEAAQLLFQHNEYTLLLQRLLLLFVAQKVPNVVPSVGQGPSSCSDCSRQNHSTGSRRQSQKPSWHFAHESGGRRCRQINFERLRCREYRRQNMINWKIILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H867</accession>
    <name>A0A914H867_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14130.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14130.t1"/>
        <property type="gene ID" value="Gr19_v10_g14130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="543"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="1095"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1357"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1366"/>
            <end position="1384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14130.t1"/>
        </source>
    </evidence>
    <sequence length="1596" mass="180240" checksum="BE6596CD6C991F9C" modified="2023-02-22" version="1">MDAATLQRVLDNVLAQSEARVQQMLKAATPANNDLANANLTNSIDARIGKFKYDPENGHTFDQWFKRYGKIIEEDGKELPEATKVRLLLGKMADEEYSKYRDSVSPTLPDQIKWAETLTNLKELFAETRSLFVRRYDCFKIRQQPRQDITSLVALINASCENANLSLTKEELKCIILVIALRDENHDLRQKCLKMLEDSRKTGTAITLKKVEEELRTIQLVKESALSLMSPSVATNAIRARPQQWRDSKSKPYLQQHGEQRSYNQQSGSSNSTEKGKLFRGPPTHPCGSCGLSNHWRADCRLKDAICSKCQRKGHIAKVCRQTTKAPPRKDRSFLSIGVQTHLMAMGTTQPRYWKILITINGVQNRMNVDTGAQATIIPIRTWIKLGKPALSPSDIDAKNCNGEPVPINGKFECVVKTTRSSPKTLTAYVSETIEQDLLGLPWIEQLEIIPTEILFQEVRTKARCNPSKTASQHPTNVNDAQSLISALQSDFSEVFSSDLGRCTKAKAHLILKPDAKPVYCKARPVPHGAIDAVNDELDRLLKIGAIKPIEFSHWAAPILAVKKKNGKTRVCIDFSTGLNNALELNRHPLPRPENIYAALNGAAYFSNLDLRDAYLQMELDTESQQLCALNTHRGLFQCQRLPFGVKSAPSIFQHLMDQICAGIPGVFAYLDDGLIATKTLEQHLSAIYQLFTRIKEFGLRIQLEKCKFLQKELLFLGHIISAEGIRPDPSRSKAIRQMPPPHDVSTLRSFLGALNYYGKFVKEMREIRAPLDQLLRKDISWNWKAEQQTAFEKAKEIMTSDLLLTHYDPSLQMVVAADASKDGIGATISHIWPDKSEKVIEHASCTLSDAQQNYSQIEKEALALVFAVQKFHRMLFGHKFTLLTDHKPLLAIFGSKKGIPIYSASRLQRWALIMTNYDFVIKYVNTAAFGQADVLSRLIANYPRPEEDRLIANICTETECYISTVLQSQTDQLPITAKEIAEVTAEDEILSEILRLSRSGWPKKVNDPEFAPYFPKRDEIIGIEGCLMYQQRIIVPSLLRARALKTLHMSHPGIVRMKALARRHFYWPGLDSAIEKVVRECEECQNALKAPTKAPLAPWPPTSQAFQRVHIDFAGPCEDGHMYLILVDSFSKWPEVCLMNTTTSSATIKVLRSVIYRSGVPEEIVSDNGTQFRSAEFAGFCKEFGIKHTFTPPFHPQSNGQVERFVDTFKRAMKKCAKGDKLWAEKMLLSYRTTPSAVLNGHSPDQLFFGRKLRTTLSLIHPRGEQREFVDQKDIRKSQLKYSSQMTKQFDEKHGAKPSEFGPQDPVLLLNYKLGKAHWLPGTIVERVRHSPTYRVLVPSLGKRIVHRHANQLRRRLAFEEDGPTTDREPIPTVHADENHQPPKDQQLPQGSPPLAVRRSRRTIKPRTFYSPPPARNEIEAAILSIKLRDVIAKGNEAKVLDVMFLDNKTKGCLTAWNILAEFLSFILDKKEGCTLKIQQVQPKYSSKQEMSFLFVNTSKIAVSGKKTENQVYLLADFKKSGSYSGGVRVCIAHTAYFPNSLKFVIGEEVTINTADADINDAGVLTLTIYDEKSIVKHEDKKFQKQNLADFDYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9D6</accession>
    <name>A0A914H9D6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H9D6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1525.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1525.t2"/>
        <property type="gene ID" value="Gr19_v10_g1525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1525.t2"/>
        </source>
    </evidence>
    <sequence length="191" mass="21092" checksum="57E897632A100084" modified="2023-02-22" version="1">MEGQLVLYDPSEYIVTSQGNTISRKAKTNGTQNIILTGNSILMNDCILRGDLAYIRMGKYCIIREASIIRPPYKYFSKGFTYFSVHFGDYVLIEKGCVIVAAYVGSFIHIGEDSIIGQNCVIKDCCFIQPGSVLMPDTVVPPFSIVGGNPARVLAEWPPTCQSLMIDACTSFFDNFQPESVMTKKGNIGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9N6</accession>
    <name>A0A914H9N6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9N6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15500.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15500.t1"/>
        <property type="gene ID" value="Gr19_v10_g15500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15500.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8827" checksum="762B79255280B03E" modified="2023-02-22" version="1">MRRCYRSVEVLTDLVVLLNTASNILSQTNPQTEAHRAARPIRTWTMRRPNMSHQNPSTKLEVPERFLILSRNVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA30</accession>
    <name>A0A914HA30_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HA30"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15185.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15185.t1"/>
        <property type="gene ID" value="Gr19_v10_g15185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15185.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31838" checksum="E00FFBBF28BA4EA8" modified="2023-02-22" version="1">MGKTEECQSVHCKSYTKLANNYKDLKAKMEQYQKEQQQTIDAWVEAQQQNVARFSMQQEKIDELERKQKADQGEHRVMMDERAQFEHRKLVENHKARQTKMEQYQKEQQRTINVLSEKLETAKLVERERISNLEWELMEKNKKLEKLGNKLEKTSTAKAAVELEHQKLANEHKALQIKMEQYQKEQKRIIEKLQKSVGEGLTLQNRWDSAACHKDLALSGPDQLVIQHIGYPETTDLLVRPTARLFPCISLLLSNTKIEANFGPNFFYTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA42</accession>
    <name>A0A914HA42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 184B</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HA42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1545.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1545.t2"/>
        <property type="gene ID" value="Gr19_v10_g1545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Solute_trans_a"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1545.t2"/>
        </source>
    </evidence>
    <sequence length="459" mass="52222" checksum="67821D821339B1E4" modified="2023-02-22" version="1">MMNWCVSPVRPLFFSRSPISRKMHCLLSVLFPLTRRLQRQQLQFRSFVRLCIIAAEGTAEESFFMTNSTLPVGGNGVFFTSALAHSIAGFCTWAALFITSHQIYQHLRWYSCPSEQRWIIRILFIVPIYAFDSWLSLLFFSNDVYIYFNSVRDCYEAFVIYSFLSLCYEYLGGESNIMAEIRGKPIRPTNIWTFTCCLSGRQYTIEFLRFCKKATLQFCICKPVMALLTLMLTMVGKYEDGNWSLDKGYIYVTFVYNLSISLALYGLFLFYTATRDLLHPYNPVLKFLTVKSVIFLSFWQGFLLAILGATSAIDPIYDSEGNELIGRGTVAAGYQNFFICIEMFFAAIALRFAFSVSAYIDAHTVTAGSDVRPMTLQSISSSLKETMNPRDIMQDAIHNFHPQYQQYTQHSNPSRSTNGQGLPASIPSDPAALAQTSTDLRLASAIYRHNAEPHTQSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAJ8</accession>
    <name>A0A914HAJ8_GLORO</name>
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        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAJ8"/>
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        <property type="gene ID" value="Gr19_v10_g14797"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
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    </dbReference>
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        <property type="entry name" value="FANCL_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14797.t1"/>
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    </evidence>
    <sequence length="113" mass="12974" checksum="A86EE32818DE0942" modified="2023-02-22" version="1">MRDLKEEVGECAICLDEIDGDEMVRQLPACQHIFHTNCILAWFKQHITCPICRAKVFKTEDGKTEPVGVRQLPTLLQLIETEETLLLRLLRLLGLCKFTTNCHCCLLALLMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB24</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB24"/>
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        <property type="gene ID" value="Gr19_v10_g14943"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038100077" evidence="2">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14943.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25631" checksum="80845610A09D94B1" modified="2023-02-22" version="1">MLGWWRLLLLYGIAINLGIDESVSTALDVNGSKASDEKSSKGVNGSKASEKNGSTASDMKAAIVADPFGLINMSGLIARRFGQFFPTQSPPPPSSSCYVALRHRDYPPPSELLDKMNHWGSDDFKEGKTHVERRCTNIPECQTFTCKEKGKKVFVVNACGRPEGGCDDYIDKLCKGAGECDICTNEKEDSLCNKEKLEFFPKKPPKNTTAVSGAGVALHSSILFSLLPICVVMWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBB7</accession>
    <name>A0A914HBB7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBB7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15775.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15775.t1"/>
        <property type="gene ID" value="Gr19_v10_g15775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15775.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7535" checksum="856119830DDF4D6E" modified="2023-02-22" version="1">MPGESILHAWDELFTSADRSIGTGETGGRTARFGGIRSFAHPTRRLDENDDDDRAAWPLLVVGNKSIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBV7</accession>
    <name>A0A914HBV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15170.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15170.t1"/>
        <property type="gene ID" value="Gr19_v10_g15170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15170.t1"/>
        </source>
    </evidence>
    <sequence length="566" mass="62324" checksum="1B4A81E08640F50B" modified="2023-02-22" version="1">MEQENISVDEEKETFILSSNIHAEEGIPVSDEEDENALEFNQLEHNNLASAEAPNVPSTTVHVVDELSVATEISDYIKVNRINLGELDTSIDMWAICDAISAAHSGLPDSLLRAAFLLVLDGSYSYAQNNSWIRGHLDTLSRVWKREMMNEKCSNRPTKFVSSSADISSPKSASGECVADESVRQPTCLEKDGRDQQQLQHAHDVDGSGVAEKASTTSKSRRQRRHVAKRKRALAVMMGVGQMLQARRTLTTEGGQMDVDEDEYGNFSIGGTELTFESWGKLNTIQEADIVYSGEQQQPIQDQDSSVTRPQQQQNGCRVEEKAEDKMEKLRQSNSNANIVSTTTAGGEHQKRGGDNDSAATALLKGMAQRYPTVAEVEVPSLMPATADDRRLPPTTNAAAAAKFLPKKAQKVAKMERKQKRRAEKDEGELSSSDSEEPTSSDEEEDNDNDDFGSSADEAAAALQSRTLLVAARERRRMRRVDEQKQGASSAQNLQALLRKCFELRTRIVGKLSIGQKAMFRDCLSKSISGTLQQQSQQPQQHQLQQLIHSVAGKPAADASAEMVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCD2</accession>
    <name>A0A914HCD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15310.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15310.t2"/>
        <property type="gene ID" value="Gr19_v10_g15310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF540">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 99A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="107"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="210"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="683"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="840"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15310.t2"/>
        </source>
    </evidence>
    <sequence length="1192" mass="132822" checksum="B1CC4968D797043E" modified="2023-02-22" version="1">MFANFLVRPPVPPKPTVVKHSDRSATLQWAQYASSAAHQPIIRFSILVAKTEDGSLRVVSTPDNRTTIKIDGLWPNTRYSFSVRAENAVGESAFGAEAAFRTVGQAPRTAPKITSLTNGTTPFCVELSWDFPELEKEITPIVGFRIMIHRVGTGALREWYVKGNKVRAQTLCTLEAYADYVLTIEADNGFGYSPGETMPFRTDESAPDDPPQLIQIRPVVRGEALYLTWREPSRPNGIVTDYVIYFKDIPSKREMSRLSLSVSPNEPSKAFAYNLTKLLPTTRYKIQLAAATSKGEGMRSEALLADTDYSASRETPAVTNLSFSCDNSLLTLQWTIVPSAIPTGANANFRINLLSSLGQSRIFNVSASETSQKLFIDKVQQSERISLTILATVQSRADPTIWLDGPSSAPAHFVLLAAGWKCHFRSTACPQALSLSKTTICEHFATHSINTQQLFGGQQADQQRGDANGPFVFLIFGAAITLAISVLFTCILRRRCFLFKAFLRHKKDKKNHQKRGPLLAEKGHHIRHKGAESTSLVQRGTNGVQDSVVLPPITVPNGAAGTHTLNSSNNIFSGAETTNSGDASCCDGPEDGDDDEPEELLGMNDGRAATTTVSVLHFDAYFEEMSANANAGFKRQFKELELDTLAMLEREQAAASVSENCAKMMPSSCVNGIMSNNEGEKFKNRYVDVIALPRKSRIQLGDRKGCRQHYINANYVDSCDVKRAYIATQAPLPHTFADFWAMVWQERSNVLVALTNMVESGMKKCDQYWPNCTGDFVQADDFRITLNAQRTNSIFTHRVLQLTKTASSNGKGDDIERTVHQLHFMAWPDHGVPDSPFPLLHFINYVAELIQCPTATAFSANVNGTLAIAAESAPCVVHCSAGLGRSGAFILIDSLRRHLLSCDRIDVVDQLRRIRRQRAQLVQTLEQFIFCHEVLRHLVANGITRQPRTHFANYVRFLLSQRTPAGQRRIRAQFVDLLSCPHRPQQCAPPTAQCVPLPGYHRTNEFLLCFGMPAEREEQVWHKLWQCACQAIVLLDSCSDGQTQFDVPSQFTETDQNGAIKTINLIKTDNIHIHLRRDDGKELFIRLHRIHSTALLHNPWLQIERLQCELQDQHRGQLAVLELGTAVPSAVPFLFCVFQSAACQLEQESAVDVLLWLALYRHAVCGCWTEQTEVELVYRKVLELVELQKTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDD4</accession>
    <name>A0A914HDD4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDD4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1599.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1599.t2"/>
        <property type="gene ID" value="Gr19_v10_g1599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="6">
        <location>
            <begin position="406"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="710"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="671"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1599.t2"/>
        </source>
    </evidence>
    <sequence length="823" mass="91482" checksum="5A010779C2B2A2B9" modified="2023-02-22" version="1">MSNKLPFRRLFPKFYKFNSDFWFLKIFLTGFPNSVTPRKSLHRTFYSLLNPRVTTTRFRRSATQSASIYSALVQYLRQRVGPSTFFMRRLLAGGRQDPHYQCPAEAASPPPLSAFHSPCSILPPPPSKFFFDIERQLSARLAGEPLLRSAQQQPTPPAEAASERSSPLETPPVLSAATTAESQNANDTLTDASETIISFQQQRQQNLSANVVGHKQQQKGIDAFFAALTNASRDNGGSSSASYQQQQMSLVEPEHQNSRRNFFTQQSPIVARLSSELCAPQHIAHEPSAQPLVQKIQNVTNTSLSANLFVSALAAQHQQQLLHHSGRIPSTDSSMKFQPAQPQLDNSLDIQRIDNQSSSSRSQKMAEQQQVNTTATMAMNSPLSSEGVFIVPNIRSVDPGPSLSKPIPLLGERMDLLQFKRKEPREWSSDDVVAWILDVARRHQIPCENLNLAKFANCSGPLLMLMNEQRFKEHDPNYGSLLFAEFCKLVTDENFIDEWMKVNGSVATPSSALDPPLLAQMNVKKPAASTLLQQTAFLGQLAIQQEKRQQQQLLESVTAVEPLVDSASVTGDTSTSLFLRVAVANNQQRQKDAGGCPLPSLNRLLPSPSASAATLRQPGPHVSPASQLQPSLQQEAPNNNRGALINHQLSCTSNLMMAQQQRSHLLKPMTSAGTKRGVGRPAGSKNKVEKFVKRNKDGRPRKRSQHTKGNKLWEFIRDALKDPRTCPSIVRWEDPAEGVFRIVESERLAFLWGQKKNNQKMTYEKLSRAMRTYYEKEILVPVPKSGLYPKKLVYKFGPTAHGWRTAASLAVQAQLVLVGGSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEG3</accession>
    <name>A0A914HEG3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16600.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16600.t1"/>
        <property type="gene ID" value="Gr19_v10_g16600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF334">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16600.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="32860" checksum="2C48267FA742CE79" modified="2023-02-22" version="1">MMKRRNRRSMSCSSASSSSRLFALLGILFSTCALLGLLLLLPIIMYKANNLRAEIEEMSGRFKQHSDRVWHRMMEVDHGQIATSKNPTTRTAATIANRSPRSSWNKQHFCQGCHSLVCALGTPGPNGLPGPDGAPGEMGRQGQPGEDGFDVQLQPEADLPCVICPAGPPGQRGPQGERGRIGGAGSTGEFGFEGKEGIGGPNGARGHPGALGAKGVPGRPGLQGDQVVAGIGIKGPPGPVGAAGPKGPHGAHGKPSRDVGMAGKIGQQGPTGQPGQAGLSGEPGGFGPPGEPGEPASYCPSDCGVSHIKAPNFGTEPAEKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEN3</accession>
    <name>A0A914HEN3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEN3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16300.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16300.t1"/>
        <property type="gene ID" value="Gr19_v10_g16300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF107">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="506"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="699"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16300.t1"/>
        </source>
    </evidence>
    <sequence length="751" mass="84485" checksum="5EFB9B2DAD515CB6" modified="2023-02-22" version="1">MLHFGGHTLSTSATASSHSHAQPPHSHHRPSEPSMGVDRFGIDRMPPPPLQSMPTIPSLHSITEVAELSAERLNLYIDRQEGNDAVNEEEQQMNVTFRGEETLTTRKERWRHRLKLTLPHVGWWGSSQIQFETPNEMFIRNATAHRVQMLKDRVIAQLWLLGTQQEPNWTRNPPAFPHWAEVANDGMNAIIRDVFIDYTKNYMTPDEIIYGAGPTKWSFGASVFFSWTAITTIGYGHIVPLTIQGRISCLLYALFGIPLILVTIADMGRFLSNVCIWVDKRLFQIRKSCFARIRCFCMTACCQICVFWRRRRKFRSRKPEQCRANKSVTATTIAPSESTASGNPEEVGETPPSERPFHLNHVGPPSGTLATIEELSREAITTDDNNNEGSASESRLRPLHLRLGICSRRAQRRLKPPPFPPILDTVSEAGTFQDVSEIRTVHGEDDFEERAGTTSEDTRARADELEGGESSDMEGVEDKDDEDEVEEQYTPLEKRNRRVSALFILVVMLGYTAGGACLMQLWERWSFVDAFYFCFVTVTTIGFGDIVPQNVTFLPATLAYIVIGLIITTMCIDLVGSAYIQDIHLYGRALGSSFLTIGGKVIHLGEVFSYVAFLQKNYGLTPDQLDRLAQLPEEYLLDCLINGRQPDLNWIGGRPFIPPDIYYFKWIEQPRTLSFTSERQLASSESMDLNTSLCSTARTLTPHGHRGQNDGVGGVGGTVGQRRDAQRKGGAQNRWAPTLKRKSCEGTRKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFC5</accession>
    <name>A0A914HFC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone RNA hairpin-binding protein RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17006.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17006.t1"/>
        <property type="gene ID" value="Gr19_v10_g17006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="2">
        <location>
            <begin position="469"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17006.t1"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122511" checksum="0FE5FAA26CA268B2" modified="2023-02-22" version="1">MYQRQEGGNNWSRSGGRNNGPNDNPNAGNWNARSYGGRNNGPNDNSNVAFGGGNVQRNEGGNNWSSASRSHGGQTNGQNDVSEVHAPPVHWTDILEVDFGSGKHFTSADEVFEAVDKAAHGPLSSPTRKNVVEIEYRPGYRYAKLLMVSSEAAVYAFDQLNGRSLGGRKIKVYFGRRKDYEYFNRLWKQKEDSVAKAVKEGEATQKEEVNQDGEENESDQDGYEGEESYIDQKEGVEEVDDDHKEEQEVDGDQKEEQEVDGDQKEEQEVDGGDQKEEQEVDGGNQKEEQEVDGGDQKEEQEIDGGQKEEQEIDGGKKEGVEEVDDDQDEDEVVDDSAEEVDSDQGEDEVVDDSAEEIDGGQKEEQEVDGGDQKDEIDGGQKEGVEEVDDDQKEEQEVDGGDQKEEQEVDGGDQKEEQEVDGDQKEEQEIDGGQKECVEEVDDDQKEEQEVDGDPCKGCEPRTGWCTDLVTLRRRGRELQKMKEKPIYKIYLSQIPKFSRARIPNKYANCSRRSWDKQVRLWKLSIYKLLGMAAGGSDSHNTSPTQHFAYLHFAYTANRQQLLGRSIDLNRLVSQRINAALLRSLDVAISKFEAEGLHYIMVLDNLVEVNRLCHRLLSDHLGSLADFQDLLLEANRQVSAPNGRITLHVFAELTDDLLPNFCFSTTTRRFVRGKLNYRKPPERGRPPNVGVAKLVGYQGISAILFDLLCLARRLLNDQIKTHFRVLLGLMPKTCKLQRFEYGVEGNLQYFIHQLRDFSAYGPLRRECCQSLRELSNILALALLVELRLAQEEMFDLLAAAAFTNQIPKLYAKSTKTKQIVYSFTDLEEQEMKMHKLESKYSRLQIATIVRQLGTETQTKIAAENELLTRERFCCGLNIIEMVLNRLRDTLLSDPVWRGPVPSNGVMWVDECHEFYRLWSAFQLALSLAQVQLQGQQLSFIGSASSSLSSVENVYGTLKKGVTVGSSSISMPLNGGVQQQQQGTTVEELFGDGIYWAGCAIIRLLGQHRRFEVLDFSYHILRQQQQTIAGLIDRIRRVQAQHNQVFAFLGNYCGQLDGQEEQEVRHFAPPVYQPQQNPYANGHEGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFG6</accession>
    <name>A0A914HFG6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Histone H4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16491.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16491.t1"/>
        <property type="gene ID" value="Gr19_v10_g16491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="13">
        <location>
            <begin position="38"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16491.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11621" checksum="7B3DFF862D3DD450" modified="2023-02-22" version="1">MSGHGTGATGTGQQGARRQRKVLRDSIKRITKPSILRLARRAGVTRINERVYEAVRAALRDYLSRILRDAAVYCEHARRKTMKSMDVIYALRRQGNALYGHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFU3</accession>
    <name>A0A914HFU3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFU3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16232.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16232.t1"/>
        <property type="gene ID" value="Gr19_v10_g16232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16232.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12670" checksum="E94B386998CCCDE4" modified="2023-02-22" version="1">MCCTFTGQTSTIFVKSSKTRWNSTLSSLKSVQFHKENLQNYLVQHPTCASVRLINRLSQADFDEKMPLCRVTNILSMCSKNTSQNTIVNFHVSYAKSWDEELTMFYERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGM9</accession>
    <name>A0A914HGM9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGM9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17.t1"/>
        <property type="gene ID" value="Gr19_v10_g17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14181" checksum="1E4DA0705FB109A5" modified="2023-02-22" version="1">MLIVAVAVVAHSFPLNMTFESNDTSVIDDTLWSLVNLSSDSREHNGTIYSAPEATDTLLTITIIVAGCLLLTVLYVLLVDPRNHHDGKQHNVIYRDQEKLKLIKRQEKTGQQQAPLEGNCRPLSQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIT8</accession>
    <name>A0A914HIT8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIT8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17297.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17297.t1"/>
        <property type="gene ID" value="Gr19_v10_g17297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17297.t1"/>
        </source>
    </evidence>
    <sequence length="1139" mass="126697" checksum="BA8B680EF631667E" modified="2023-02-22" version="1">MLLDRCSSISSLSYFAILHKVNDATHKLIGKMHAFVMMLESLRVKSRTTFFPQSPRAVEWRHLSLTKNLNIMSSTLTYSCWTDPRVQKQHEREFIQRFSGSNFVYGVSRNNYDDLIKRVGDVFGSNDKIRNSFKVQDRLVNGVWVVRLVDNDGRVLLPLEDVFAETERAHMKGNHRPRTPLHTQLRVEFVYPTRLMVDFVVDRCPVCSEKKKRQETKVPEEPHVNPTTLRFTKDHGNYRHKKLHVPQDPITETVSVAVESTAARAFSMINNLIHASNPATSSTPHGSLLPPHCINSPIPILGRQPPSTAGPSSFMPSFLTSTPVDRKASEKSRLVPLNSTTFSPNLSLPIDGPNDTGISVESNFIRFLNNSNQSQSGHQYLSIIREEQATSLLSAKASTGISGKGVERQGDGGGSEQLSSKNVASAGRPFEPSLQSAFQAVHNALPIKQEADDSLDAFQDNSHLTDEDMKNPEIQHILSELGKERFGTWCIMTSRSDTKRTYYYNSQTGISQNEMPSIWEVETKKRLKELNKRVPPEKLASVENCHSVSTIENAKSKSNEAPKFGIEGPLTSDVSVTKPFNGTNDALELLFGNGEESQENSAKVTPPEKELGLGDFCDMFQDELAGEFEVLGQGTVTLTLADANTENAPAAMENINLSNIPFGENICGDDVPTEQQIPKQKECVGEVAPVAAVSVPSAAVSIPSSNSKQKEIAPLAAVSVPPSNSKQKEISPLAAVSVPSSNSKQKEIAPLAAVSVPPSNSKQKELHVRNEKRLVKTGQTKKSKKNSTGLTLPKAAQIFGKRPFQPKQTVKKKNEASKSERSEDDEVKRPPPLLVHKMPICRVMVDIMSKEMIQNLLPHFFKKSLDPENDFISSSKLESEGDFISSSKLESESVFISSSNISNRTPRSNRASARLSQHVKQEIFQCVKCTRTRTFVGEQSYHLHEVSRHRNCVSACAFVVEYMEKLPLVGLSGVCFSCLPCDQTFTCAEYWDHMRSKHNAQIGARHNRIAKLIADFKDGKIQKLDIKNEFLSDYEDDDDFMAKDKTWNGRDGEWKQLELGTKNRRKTMAKLSGKKRRVKTEAVEDEPKSVEAFDERVEGTSNGVIVDTEPCCSSSAFGVSSDAPIQYNESILKKSRKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK09</accession>
    <name>A0A914HK09_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2029.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2029.t1"/>
        <property type="gene ID" value="Gr19_v10_g2029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037915511" evidence="1">
        <location>
            <begin position="22"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2029.t1"/>
        </source>
    </evidence>
    <sequence length="669" mass="77974" checksum="06DA7FE81AD6353E" modified="2023-02-22" version="1">MLALLFITFINYLGNYYSVCASPPPYQWNLTNSYDNVQIFAQLIDGIYQQSKPIDKLSFNLTFVKYASELANLRVIEHNNEEARPTFKAHTGVLDIQDELVGLQRYYSNKLDHFIANEFNKNILCREKAIPKKVMDQIMQLIFSYAARILLCLTCKDYYSSNRIGEWQLQTLLSAYKILAARNGNNENGIFPFPIEQIGGKGDHMWAKFMNQNISEQASEQKQFIENFNFVLKLSKFSLSYYEIYKVLEAILIETNSAAPSSAINNNNHLPTNEKPEVYTFLKQYFIAKLDHKSMKLKEYNVNKVDCAFVRFGRELEQRFVEYHSYIGYLGFLEYVQRMEKECAKAPWGNKTKKDTLYWGKSQQLEMELFQEPLLNYARAIQIDSHECKAVLQFAVALSKIVVNFELNSDKKNIEYSLDGITKLNEFKLLLHIIDAENRQKLENFENNPKKHSLNEFSTLLKQTIKEYSSCTSLCPFRGHFGLNDGELPKFGQILFETFNKYSDNVKYDETRQLLSFPSALSEHILGRLNVFVQRLILTTITEIGKELDFVKTIQNIASMDNIEIIRLKTIRMSFMNTKLFKLLFILAIRLSAQIDQNDLAEKYLKTFLFAFNQSLGMSNISVGFFALKIRNINKMVEVNLPTWKLPYYIYLQNKNELEQENALKNFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK75</accession>
    <name>A0A914HK75_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17629.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17629.t1"/>
        <property type="gene ID" value="Gr19_v10_g17629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058814">
        <property type="entry name" value="ZIG1/7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26428">
        <property type="entry name" value="Zwei_Ig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037388970" evidence="6">
        <location>
            <begin position="27"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="150"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17629.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36421" checksum="AA563E681BBC2AA4" modified="2023-02-22" version="1">MNSSSGSFFFTVLAIFVAIQSNGVWAAEPFAQGNLALIFDANSAKSTENGAQMANLSSLWCQATSNGNDQLPIKSARFVHVHPLPLRHHQARLNPDGNRAFLDFGLVPTSAIGKYRCEITTEQDKLVTGNLFVYMRPVLSANASMRFDRPEEANAFAWVGPSNKMAAGESATVRCPVVGYPKPTLSWSKDGTALNLSVIVHDDDGRPQLKYLLDGENLHIRRVCEKDEGIYKCVAHNEFPPRVDAPKERFELSLEQHLRVTSSLSWLPPLLVIIVCLLLLVAIIYGCSAWKKYKHKQYNVAQKERELGKRDAEKQRLPPAEDDEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKX0</accession>
    <name>A0A914HKX0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKX0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17815.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17815.t2"/>
        <property type="gene ID" value="Gr19_v10_g17815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="106"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="492"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="700"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17815.t2"/>
        </source>
    </evidence>
    <sequence length="910" mass="102434" checksum="B776895C80EF934B" modified="2023-02-22" version="1">MPCSKNLRKFMPWASNGGGRSGAFLALDANLELLQRTGQLDVYEYGRTLANSRQHLVDTVDQYMFIYDVLCEAVLCSLQPIGMHQLKNRSGMYKARKDRELMEVQDSHENKLLLMLTAPLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGESKDYTYINAVEVDGFTRKSEFIVTEWPKVPTLDSFWTLVFDHNVHTVICLTNQPTDIKQYPQFVHNKGKRNYGPFTVEIVNYQQYPGLQSHMVKISKRPMDEVIERRKWLWSRKKGDQRDGLDAGSARSTGGHHHPRVRRRPTLSNFLAECERYRRRNSSMATGSGSAAGGGLPIDDTNAHPEVVVVVVVVIIIVEYVMYLKRKPVIELLLHAHDADAFTFLMFKLYTQLGRSPPSPLLEGEEVGHVHGQPGSDLLVDDQQQRHVCAQLSVLCPPARCRIRLARRLCRQHRGACRSGRNRAEGFKCCFAAALTSAQSATSRGRRLGGEWDKRLERRGDAVVALFDERGVAAASGTREQRDNDDAATMAHAETGTTTTGYVSTLRRSTVTTTAARRRRLSRRRKRRERRMARTFSQPNLGTLERFEKVSASDGRPTSRRESREFAAPSGAVVQNSVFKIPSFRNRRGISRTWATDTPTEPVTMNSQPNPEKGANKKLTFMISEIMATGASQQQLEAEVRLCCIIQVKMWPMENKVPLSTTALIEVLKMTRSWRKRAPDRPEQRPTIVMSHNGVSRCGIFIAANVCIDQMEMDHEVDVFHAVKMIRLNRPQLIDMKDEYKYLYDLMLHWYMTSPELRQFEPPEMSVVSDAEEEETEASDGDAPLMTRSQSGSTRRRPGSIRHDGQSLARSKSNRASSRHGSKAAAAVSIQRVPTTNSGTNNNTLAVSGSALARNASSMSGTSAGSRKREPVYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL79</accession>
    <name>A0A914HL79_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HL79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2166.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2166.t2"/>
        <property type="gene ID" value="Gr19_v10_g2166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009697">
        <property type="term" value="P:salicylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051331">
        <property type="entry name" value="Chorismate_mutase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008240">
        <property type="entry name" value="Chorismate_mutase_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01806">
        <property type="entry name" value="CM_mono2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38041">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38041:SF2">
        <property type="entry name" value="SECRETED CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="6">
        <location>
            <begin position="158"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="840"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="896"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2166.t2"/>
        </source>
    </evidence>
    <sequence length="937" mass="105934" checksum="83B956BA43DFB6AF" modified="2023-02-22" version="1">MGLNMLPPSPTQKTLSTYAGESGSKSKAHENNSIHEKHSGDELSKSGKTKRHIAHSPNKKESKQSKKQHFAKNKQSSLQSCEERGRHYVNHCIEMSTKNGQCHENKFPMRKMDCLHLKKFINTNLHTLVEEPTGGETHQHHSPRHADKGMHPDGEHVGAFVTANNVMCCSVDMGSSLQHAIQLINDRLLFAHEVALYKFAHNIPIENPELEASVLKSVGNQANAAGIDAEFAVNFLLAQMEANKMIQQGYITRWESDHSFESKYVPDLEKEIRPKMSSVTNALILALIPLVDAGHQLYNDKNCIKNVEKVLESLGNLRARDLEPNGTSAMERAVKGICDKETTHAGQIINKDQEKGSSKRRNAIGKEERKTRHNESKLKAKKEHSKISNNGGVKVQSPSSRAKIQKISPRRIEIAAGKVTNEDDEHHDSSHIEWNRGNNEYAETKTPRRIAVSDRSIMVKTGDKTREVSDEVNHEAQTRPKIVDKTNAIKENVNERKENIGENRGNKKSSSKELVSRDASNEAGFARTESDANDSALYEVKTDQKKSPRRIEVSDRSIMIKAGDKTQEMGNSMSHESLTRPMTMKKTIASNELKNEQSQSAEFDNEKFGKKRAKQSSDESRPKRMESDLDDRSLIVIENSNESREVHAEKNKKDTKNTIGDNSSDEKDGRKDYSNESVANYSIKHLRKTDVSQQDKSKNEPEYTKNQSSSYERTRRIGKKRANQEESRQQSEISAEPAGFSSKTSSEPVEKENGAVENPRKSKFSMKQMLASDEENRSNYHQREATDQNSKMNNKNTVAKKEETLHEKKDDSDEFHHIELEPDAESIVIHTGGEKPVKIKLGRKKAVKEKETTNGEENDREKKIRSEGSEEQMLGKNEANFNKKLAKKLVDKSNEYVEAPEKISSEFSEKSADITEKPRDHWANYENNESNSDENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLK4</accession>
    <name>A0A914HLK4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1904.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1904.t1"/>
        <property type="gene ID" value="Gr19_v10_g1904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000049">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1770.10">
        <property type="entry name" value="TPR 1 domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038163641" description="DNA-directed DNA polymerase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="95"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="335"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="17">
        <location>
            <begin position="988"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="17">
        <location>
            <begin position="1322"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1904.t1"/>
        </source>
    </evidence>
    <sequence length="1571" mass="182468" checksum="2BC13EC10D2E1738" modified="2023-02-22" version="1">MAHAIRLMLLLLLVSCSVWPNRHQCASTTLLVWAAVIVASEIDPGVHALLWREVARHDNKNISDRAMSATILQNLNGYNEDDVDENSDEEPVHYRLERHLMSRYNNRLIPRRSTAKPIQVLFTIGLYQIIEVNEPQQYILLNSWIVERWRDDLLHWTPSQFGGMREIVLPREAVWIPDTTLYNSLVMDDQQSRRILNVKLNTLQRERSALVEMLYPTLYQFSCMLDLRFFPFDIQHCVMMFGSWSHDNTHIDYFAYDDIADAVMPSLRADGTPLHDATASGGISIEHCIPNEGWNILSTEVSRREVKFHCCENNYTLLEFKLHIQRRPLFYLVNLIIPTSIITLIAIVGFFSSSTVNDVRDEKISLGITTLLSMSILIFMVSDQMPSTSSFIPLIGWFYTSMMALISGGTLAASFVIYVQKMGIIGQRPSRNTMRWARRLGKMVWMEMPLMMKQAYAIKAKQDKIQKIRQHLELQHQKLLRRQQQNGGPNQQFGGGTSPRKPTFWQLRPRIGGTGAGQQQNEAATPIIKQWIPDTPHPDERMRDAIEDMIKKAFKRTEETMGRKVKMFGVSLTGAGLGYPVYLPYRPYPQNNADVVMEEINKLGQSGGESGDDMRTILLSHPVQMNVTCVALPAGEGPRNIHKFDYGFKEHQRIQINNNDKFCLFYALAASRNYLELHVDSFRRFMNNNSRQREAAFEILHKSGVNNMENGYGVEELSAVQKYWDQTFPGKYRIAAFEKCVDPRKSIRVLWKGPIGREAVVPIFLENNHWDGLKNFVCFFNKGKKFCIDCECFYDQAVYHTYECKARCYYCNRVGGMPCTKEREVKIECPKCRRYFYNQQCYNYHQGHQTCNIWKRCVECNKTYLFNPKSKHECGETFCRSCGICHDPKRGCYIKPIGVKEEKDIYRIVVWDSETSQDKTYKGEQKEHVINYISARVTCTECCDDGSRKDCRICGTEREKDWSEAEGREPIKEFLEWILSAFDKKFKTYLFAHNAGRFDGHFVFNYLCRAGKSPMPLINGLKIYEFTVQNSKKHSILIWRDSCLLMPVKLEAMKATFNLDCEEKPFFPYYYNKKENYNTHLPHLPPMEDYSPGSMKKEKFDKFEKWYNENKETPFYLPEELKNYCRNDTEILLKSIVEFRRILVKDITGGFDPLPRSCTNAGVAMSIFKAMFLQEEELSIVPERGYERCDRASVIAIKYLEWRSKRDNVDIKHAGNGREEQVGKYKLDGYIEKGSGRGKCIEVMGCFIHGCLKCYDPTAQLIGGRSAQDLYDETQERLAELRETLDVEEVWTCEIEQELKRDAEMKEFFEDRGNEKGPIDPRMAYAGGRTGPMKLFAKADEKKKISVYDIVSLYPAVNYETAYPTRLPDIIIPTRDEIEVSWTKPDDLKYKGLYKVRVNPPKGLRIPVLQLKCDERLLFPLCWRCASSFKKENTRCEYKCPHDECQRRYVATYTSVELAKALESGYTVDRFYRAWHYGEDNDDLFKGYVRLFLKLKEEASGFPKGVETGEQKRKWAEEYKEKYGIEIELESVKKNAGLRYTSKLMLNSLWGKFSMRNSLCKNKVIEKARTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN44</accession>
    <name>A0A914HN44_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HN44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2308.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2308.t1"/>
        <property type="gene ID" value="Gr19_v10_g2308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2308.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15356" checksum="C639042DB2E5ACD6" modified="2023-02-22" version="1">MVVDHTNICRQFINEIQERFLAETTSPVSFTISIHIWPEETVEALLSSLFPAALYNSHTNEQLWMTNTETDCLAIHRRTIPKSGHDYQQQPMIIDGWLERYADKINSSSCLRFEIDRIGPLNDEHADHSANDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNA7</accession>
    <name>A0A914HNA7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNA7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3088.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3088.t1"/>
        <property type="gene ID" value="Gr19_v10_g3088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="30"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3088.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25666" checksum="CEC75A5E237947D1" modified="2023-02-22" version="1">MQMQRRRRLPLELKCEVISALPFQHGRRMLLLGNPIAKNCIALVRKQKKNRWDSTACHYKLALSEPDRLVVQLNGEANWGWGSVRAEKPMAKNPYFEVKVVEKKGFISIGLATKQMPLDKWVGRDEGTYAYANYGTFWGHAVEVCSHLFNGRPLIGGKPPFGVGDVVGCGVNLKTRQIIYTKNGERLDTDRLLVDSPAADLFPCVTLGRPGAKIDVNFGPNFQWNINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNR3</accession>
    <name>A0A914HNR3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNR3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3221.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3221.t1"/>
        <property type="gene ID" value="Gr19_v10_g3221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037091415" evidence="2">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3221.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="26357" checksum="A9B151D171767EFA" modified="2023-02-22" version="1">MEEFWILILFAFFTTNLLDKAESVKLELKTFDEFLEKAGGTKGEAEDLKTPPPTNFGQNFHQIDRQNTQIGQIESNSTDQNPPLTESDHKDERKQKFDQMKAELKRAGFKNSYKHEIDETVAKELGLSFGTISNWKRKLGQSKLNHIYAHSEQKELMKLYYEIKGQNPIISDKKIVKRLKIGRSTLVRWKKLFKRQQLHPNSAMDILWKRMLRQMFRKLGTRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNT2</accession>
    <name>A0A914HNT2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNT2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2849.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2849.t1"/>
        <property type="gene ID" value="Gr19_v10_g2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2849.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12002" checksum="2884F779917E0FEC" modified="2023-02-22" version="1">MELTEGREEGMELTEGREEGMELTEGREEGMELTEGREEGMELTEGREEGMELTEGREEGMELTEGREEGMELTEGREEGMELTEGREEGMELTEGRKEGMRDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNW7</accession>
    <name>A0A914HNW7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNW7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2537.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2537.t1"/>
        <property type="gene ID" value="Gr19_v10_g2537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038101053" evidence="1">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2537.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21295" checksum="6C4AEC814AD21C60" modified="2023-02-22" version="1">MRCFASAISCLIILFSLTNAKESVDDDKFLAFVKDPSNFWQCKERNKVKYSIYGRTFGFKQMREHLVHKSEASLGVLFLMRQNWQCAKIVEQIKGEYERTECHKFRKYLDILFEYLFRVNVEGVDSMLVQQLPAVKPIFKLQLGERIDDGTLFDVIGSLSDISKFFFNPAQSEWCGYSLKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPG5</accession>
    <name>A0A914HPG5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HPG5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2497.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2497.t1"/>
        <property type="gene ID" value="Gr19_v10_g2497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2497.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33777" checksum="21EBC16BB9A265F1" modified="2023-02-22" version="1">MKHLLSTGNGADVHLLLGDGDKKELLPAHKTILGTASDVFDTMFRFDARNAKAAAGTEINPVEVPDVEVGAFKAMLSFIYADDSSGISEHNVFDVFYAANKYNVSGLIKACVNFPKSALRNIFLSIEQARVLGEEDFARNCLDYIDRKAATLIFSEAFLQIDQKLLCDILDRNKLMVDELTIWDAALRWADEKCSRNGKEDSAENRREMLGPALYKIRFPRMPQEDFTDIIVPSGVLTSDELVGVYLYHCHANCSLRELYPLKFSTQRRNYHAGGWSNDAFGGFANNAFDGFVEDSTDHWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPI6</accession>
    <name>A0A914HPI6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPI6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2692.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2692.t1"/>
        <property type="gene ID" value="Gr19_v10_g2692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037088587" evidence="2">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2692.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8229" checksum="62BCD9DF3AB0F07C" modified="2023-02-22" version="1">MNEFWILILFAFFANSLDKAEAVKLELKTFDEYSEKAGGTITESDHTGQIESNAEGDRKQNRKIFGKRKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ68</accession>
    <name>A0A914HQ68_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQ68"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2876.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2876.t1"/>
        <property type="gene ID" value="Gr19_v10_g2876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2876.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12230" checksum="3E58211FD8B58303" modified="2023-02-22" version="1">MDPPGAQPSNNSQQQGGARPSNKRLQQTQAQVDEVVGIMKVNVEKVLERDQKLSQLDDRADALQEGASQFEKSAATLKRKYWWKNIKMIVIMCAIVILLIIIIVIWAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQS2</accession>
    <name>A0A914HQS2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tubulin binding cofactor C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQS2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2840.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2840.t1"/>
        <property type="gene ID" value="Gr19_v10_g2840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039589">
        <property type="entry name" value="TBCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052:SF0">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037311200" evidence="1">
        <location>
            <begin position="25"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin binding cofactor C-like" evidence="2">
        <location>
            <begin position="304"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2840.t1"/>
        </source>
    </evidence>
    <sequence length="501" mass="54844" checksum="2F5C8F411AC8E0A1" modified="2023-02-22" version="1">MPPLSASLPQTFCVAIWPLGNVLACLDLAYRPKVPSDSVSCRQMALNFAWMGQIMGTTVSLPRWNCLFAVDLCPLPPSIGQFIFFAAKTATKCVVPSVKSLRFCKSTENGDSDDKLETKVPLALLCTALALFDRHDDELSAEQFVRENAALFCAIFVLTDSQTFPLLGVPLPPFCAAFASVPPFLLDKMPSTGTLLQKPFESVDSTKLARIRPEPACKLLAKWGKMPFLAMLSPDSSPTHLCPRNVSHIRRSLTAVRSAPRRRLLLEGWGRMEILSSSALRGGNMRLRGGRPTASAVFHPLALKTAIVADCVKAGPIVFGPIFGFLLIRHCKNVTISAICSHIRLDCCHNVTLFCQTADAIAIRADNCSKITLGHYNVFFDGLKYELDAVGMRLLSVEENVLLSPFEIDKNELPSSESVWKALGPEQFYLYPTPFRENCGTSFWRKFVASVPSEHWLCWQRRRSEAKAIALSLGDAVGTAMGAGGGRRGQDAAYLAKKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRB2</accession>
    <name>A0A914HRB2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GATA-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HRB2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3518.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3518.t1"/>
        <property type="gene ID" value="Gr19_v10_g3518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="361"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3518.t1"/>
        </source>
    </evidence>
    <sequence length="669" mass="71221" checksum="DC64B3114D70880D" modified="2023-02-22" version="1">MEAAPMNNNAANNGNNNNNGNDNISTISNNNGTNNDGIGIGSANQFAVVGSNPGLLMVAPATSASSIPTGPMELHTVRLYEEYTRQLLNNNNNNNSSNNPLVTTGTITLNFSPPSTSTNLYMANNNSSSGSSFYAPTANAWNNQTTSHQHQQQQQQYYIEPFNYFTDSTAYFAPSAMLGLDSLGGTYGGNFGNLQGFVTGGGIEAPVQYHHPQGHHHSTLAGGGDLLMGGGPLMPAAQPDRECTACGIEIDAVRFDARGYSICGPCHDHQQMELQQHLQQQPLDSSTTSQMSGGLYVNAEQALPPLASQLLEVKDDPAAAAVAAAMPSTSKGTAKPKGVKKLAPDGAAVPATKNHPPKGGGRQNLVCSNCHGSTTTLWRRNHHGEPVCNACGLYYKLHHIDRPLTMRKETVQTRKRKARGGGGGGGGIGTAMDESCPPAKCKKGGQKKSSSNSNSTKNEKQLEPNNQILGLSTALKYELAPPPVAGASHYYIYEQPQPSSSSAAAAAAAVGTSSLIAFNSEQQTLHPPPPYPAAYLMGGQEFQQQLVAEYQQQRPSSDQLQHQQQQQHYHLLNANPTTSSSTTSYNSIIAANYSNFCATTPPQYQKQQQPLQLQHQQHFVVAEQSTTSPSSVCNTTATTATTNINSDKERGDHQQQAECEQADLVANSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRX1</accession>
    <name>A0A914HRX1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRX1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4101.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4101.t1"/>
        <property type="gene ID" value="Gr19_v10_g4101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4101.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16005" checksum="C845B9B987206BDC" modified="2023-02-22" version="1">MGGWQFQLEAVVHTLAAKPFDQKANPDKSNKFSMFESKDDFHGSNPSAYRLPAPDSVFISAPQSPDARKSACTKPTRIWTDTLKLVIYATAIIILVLLLLGIVVAAIAMLFDDDRALGRALHRWKATRNGGTNSGNAMSTNGDGDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS68</accession>
    <name>A0A914HS68_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS68"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3464.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3464.t1"/>
        <property type="gene ID" value="Gr19_v10_g3464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3464.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20371" checksum="19EEBA09875D6C2D" modified="2023-02-22" version="1">MILVAFYAFFASFLFFGNCVKFVIFAFGFNYITLRTYALESTVSSELSFQYGIKQVENTSAHWEKPVMCLLGEPNHQPENQYFTNTIPENVKKLTISLSVLMSIGLICYILNVLFVEVIIPLLNLETFIIEYFVTPISLSLQSMAYGSSAPVLYFCSAQYRSAFRTQFSHQANQVTPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS69</accession>
    <name>A0A914HS69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HS69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3258.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3258.t1"/>
        <property type="gene ID" value="Gr19_v10_g3258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037102927" evidence="3">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3258.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33408" checksum="F4579873028B93FD" modified="2023-02-22" version="1">MEALWLLIMVALFATNSLDKAESVKVKLELKTFDEIFGEGWWDKDEAAEDLKMPEPTNFGQNVHHQIDRQNTQIGQSEPNSTDQNLPLTESDHSGQIEPNSTDQDTPITEFDHLGQIEPNSTDQNPPLTESDHSYNAKNGEEQNKITSNENIAEYERKQKFDQMKAKLTRDGYKNTYHHEIDETVAKELGLNFGTIYSWKKELGETKPNHKHSHSEKMQLIKQYYEIKDKDSKINDQNIAKMLKINACTLYRWKKQFKRQHFHQNSVDSVEKNDAANVQEIGNSNLESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS75</accession>
    <name>A0A914HS75_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4174.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4174.t1"/>
        <property type="gene ID" value="Gr19_v10_g4174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4174.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20374" checksum="DEC10C549E682D24" modified="2023-02-22" version="1">MLTEKKMLKKKRKMMTKNMAITRAMFPKRPMIMGKVGKSWNSSNCVRTTATNWRERNSAEIIGEDGKFTEGKFEEEESGINVGTSRQKSNGKPLPTAVIVICMSTVGFVMLAVFVGMCVAKKKLDCYTYRRQIRCFGDVLNTEHIKEALAEAVRKSVSEHQSVMINVLIGKTNFREGPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSK6</accession>
    <name>A0A914HSK6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Protein crumbs</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g3570.t4">
        <property type="protein sequence ID" value="Gr19_v10_g3570.t4"/>
        <property type="gene ID" value="Gr19_v10_g3570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000029">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037471808" evidence="14">
        <location>
            <begin position="41"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1870"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="261"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="338"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="394"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="456"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="661"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="831"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="881"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1095"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="1169"/>
            <end position="1360"/>
        </location>
    </feature>
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        <location>
            <begin position="1362"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1400"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1484"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1523"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1575"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1617"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1680"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1721"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1760"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="520"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1928"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1125"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1430"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1511"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1563"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1605"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1690"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1709"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1792"/>
            <end position="1801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3570.t4"/>
        </source>
    </evidence>
    <sequence length="1947" mass="212499" checksum="C84F765F3D786A34" modified="2023-02-22" version="1">MQLDLFKDGQQFYKYYARTVPLYLLFLLVLLPQALPVSSAGPSNDVAAAATREKCRSNVCFNEGECFVTRGGGRATKFFCECRRGFAGLLCELKCELRCQNGGKCQKLAEKGEFCECPGGFRGPLCAENDKINAEQLEDCRHNARACPFAHVCLQDPESGEFHCERNQCLRWGQSPCANNATCRPIKDDFVCECPAGFHGRHCADDIDECLEANVGRSAEGDAGADFVRGPCQNGGECVNTPGTFECQCAPGYEGSICQNHIGACAKSPCGERGTCKDMDNNGTYECNCYGNFTGKHCETECQPPRVLVTHLNESGAHAALASCICPPGKMGENCELHVTPCSGEDARGQCQNGGQCVPAGSKAFCICPTGFSGPTCEQRDVNADEGLQKSSKLSEECTVNGRKCQNGGRCEQRRHGHTGNFSSSRCQCSKNFTGTWCERTLRHDDVLGKNVTSPPTDFCSPNPCLNDGKCLTKENGPLCECPVGRFAGAQCQLKCHCSPGELCAESEVQRGIAECFQQNQTPLTPSPQTQQTLTSTLPPPSATDSQTESGDDQEEDEADQEDIVDENFDTFVGWSNETTVSNCTACANGAKCVRIADRIRCLCGADYAGAQCDVKKPLCDSLMCHKPGELCQPVRGVPGKKDEARCECPPGMGGKKCSLPNTMGFTNVSVVLLQSARNKNYFLTFGFRTTLPTVHLASGENLLGQIEYTLRLQDGIVQLRVDTNGTEQFTELEVPIRVNDDDWYQLTLWSTRKRGTAFELWHPETGFLLARHLLSSGQKLANVWTTRLGQQRGDNAPFIGCMRAVALNGAEPIRDDDQGRAINVQSGCHRHEQCSSTVSSLDMTAPCANGGVCLDLWDKFVCRCPRPFLPPRCVEQPQEATFGHGGQPSNCLYALSSDDKSSVAERTHTSFLLRTSDHRGGGSTPTLAMPLVYLGESAGTNAEPDTSTFLAVELRNGVPRLNARLGGKQVYSVNATERVDDGKVHLVELDRVGNLIKLKVDDGKWHSVRIARSFEHPLLADQLFVGALPSSNLPIAAFVTGNMSDQYFKGTLQDLRINDRLVPFFNHLEDKLLPRVPLFGHKLADQNLLQGTVSDDVCATHSSQKPCGAHGTCVNTFNNFECRCTSGWMGLRCKQRDFCGNSTNGTTKFCPEGTECQNVQGGFVCTSTASLFTSSSLRYTIRQLSEGVDKSKIGNFTLEIRTRTRNGHLLKLQSSNYSLILQLKNGVLQLSSGNANFTSTEHNSTSNITDGQWHRLMIRQNSKGNSIILFIDNVVMRLGNALNFSLAHFATDKLARISFGRMPEQDGFKGCLRNVRLSPFPPLIFYPPQKVPKIVEAMASAQITHFELQHHENVVPNGCQSSNVCAKNPCLNGGTCEDQWNAMRCQCARGFAGENCELNQNECELRGGHAVCAPNGKCVDAPNGFRCVCANGFSGPKCSDANELCRPGTCQNGGGEKCRTVNGTTTECECGPKHIGAWCQLDAGIKCSEEPCQNEGRCFQSAHGQVGCWCKPGFTGPLCELRVDPCRTQPCANGGKCVPVALSPSNANNSTTTTAPSFHCECAREFEGTLCERLADACARIGAREPCGRHGKCENIWGGHRCTCDRGWRGRDCSVRVDKCAEEAPCVNGGTCVDQQNGTDADFRCQCPPFYRGDRWQAQGETYACRCARGFRGKRCEQRVDVCSEQEPCQNGGTCVPLQQSDDFRCACIAGFTGKKCEVDIDECAAKPCLHGGRCFERVNSFECDCHGTGYKGLRCEQDVDECAAAAANAVPQHCVNGVCTNSDGDYHCECRPGYIGKRCHMANPCVPNPLTNRTRHNCAHGRCVRPRVQQAARGEEFVQHECECAEGFTGELCMHLVEPQHQLSLSNFIGAGVVVIVLCICLGALLYFFAVCARRKRAFQGTYSPSNQELVAQARLFSQRQFQRQPLHRNQLSSGGGLHKTRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSV6</accession>
    <name>A0A914HSV6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSV6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4164.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4164.t1"/>
        <property type="gene ID" value="Gr19_v10_g4164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="10">
        <location>
            <begin position="94"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4164.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19939" checksum="1C42A0E48E7AA059" modified="2023-02-22" version="1">MHTIDHAYGIVWGLKMNITRQRTSCSLSVHSYALNASHFLGQRFAPNTQSMHTIDHAYGIFKQDSIVLFFNPITGFQVEQLRIPGGKGRFDQFYWNDKARRTEVGVVELFEGLQQTVFDSLTAHSRPVQVAIKTYIFSQGINAMAATSIEQGLTSQTVLVAQPFGGILEAVFWTPDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSX0</accession>
    <name>A0A914HSX0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSX0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3665.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3665.t2"/>
        <property type="gene ID" value="Gr19_v10_g3665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037770211" evidence="2">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3665.t2"/>
        </source>
    </evidence>
    <sequence length="116" mass="13067" checksum="77BC40D4F44E7904" modified="2023-02-22" version="1">MLQLISPLILLTILVANYEAVSHDTTKNLHAQKKATIIENEAMQANRMEGPAGVKTKPYEALKMRASEQMPSKPNKQLKKTKQIIIKAKPYKALKMRATEQMPSEPDKPLKKGEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU12</accession>
    <name>A0A914HU12_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4669.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4669.t2"/>
        <property type="gene ID" value="Gr19_v10_g4669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4669.t2"/>
        </source>
    </evidence>
    <sequence length="830" mass="91978" checksum="5337B2345395385F" modified="2023-02-22" version="1">MPVETKGPELIKFILGHGVPSFVNIFSICARKSRGALTASEKDHQNESDTLLRQGQTLMKRIQGELNDGLMENSNKILAMLVKLLETECKLFKADKQTGTDTYGVKEQIMKFCGLKKGEKLDIKEATKKLTMSFKKEIPKMIEDMKKAETTVERSIDGGDGTLAGPPSITLRAHVNLLRLINPKMEPGPAKDAIENVLNKTNTVPLHKGRSTVAIMPSDLMKLTMELWMKVVKNIVEKGQEQKPFQTQRSQTKHRRSRRNPFARQTESEMRLLMFIMCIFAFVFIGDRAIRGANVTALLAGIATMWFINRLHHQYDNPVTKQSHATTNIVINDLIGWANQLLNRTSHGNNNINNGQGMYNQQVPTWADVQHATTTAAGSNFPPPPADSERSPPTSFAAQPVESRNRTMPSGNGINNNNNGRHGTAVDLRYSSRDGLDHPRVVTANFHYSSRNVLDSQNANGMPDGNNDDFIRSGPNTGPSNGSATGINTNLADERTRTPDGDNMTENNAENGVNSSPRLCNWCRTHTHDSSSCNSSDSEEGCIENDSMPESSNRKGINGDEKDSTRKGSEHRHSTSEDNKSSDEKDDSTPHRHTNDEKSDEDDEDAETDPERCPGVTEPERNAYGGAVEFVSNSFWMLIKIGLFLFVSIKLLFFGIIDEVSSCAVEMHDFGCCFEGYFLYDCPGAYKPDCNMFGHNCVGCRYVFEPYECTRHRVACSCYYCCEPQYAESCPDGCAECIKDGEGGCPQNSGKFFKSLGNSSSSMLASVAKAREHFDMIDVDKNGSISLRNVAAKNVSWFAELDRNGNNQIEPGEFDRSLIGVVNNNNQTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUK6</accession>
    <name>A0A914HUK6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HUK6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4810.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4810.t1"/>
        <property type="gene ID" value="Gr19_v10_g4810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase central" evidence="11">
        <location>
            <begin position="566"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4810.t1"/>
        </source>
    </evidence>
    <sequence length="882" mass="103723" checksum="2CA1BCBB921B3214" modified="2023-02-22" version="1">MANAKIGTDGVDDANANFQIYGPEVENEGTKLNDFADDQFLASEYAVLLDAIAADQQNDGHGIAEVINSLNVGIFANEISHRLEAIEWLGGDQRLNEKTKRIVDQWEGLKELKHSAKYNYSEDILRMLHHLLKEVLEEMDEFGINLEDNKFENTRKDSNQNIDEKSRELLNQLQSRKFGNAIVQGNIKSWEKMSKIQKKLALLNIFGLGGSFEDKKNDENFEKFQRNLELLKRAATQRKLDGQIFSHYKNNANLAQFVQKKDKLNFGESNSQILPTEKWQELNSADGLERKLRETEKLKNAIKLSDERGNVKQILVELNKIINDWSDEAQFQFPSLYFLKDLENKFEPICILPDGFDHELIFGKFQCDFLNRESCLDTSLYCALCKKLKLTFIQRHPKSNFLFVPMMEIGLENVQIEVKFVQIPEFSHIPRINFNAKQLDIFLIKFAQNIHKLEDNDHFDEGVYWHETQTRKELRKKYENAEKNKAKNAEEMEKFDKITELFHLSRKNALRQRQMVKERKETLFVLSDDAFYKKLLQFLLLKNDYETIINKFELNDEFGIKTLDKFRTIFAYLERWAQNNHIFCQTLGYLSTKMLLLMLTKVFLLFPDSTTPFLIDKFFLIYSEWKWPMPVQLTELSDKRRVGEFLNWTPAMEWFGRRHFAWENLPKNVRTDLLKNIRKEMAMAVITPTFPERNLAENVNISSSKVVQNELKKALKKIRIRRDLDAIIEPIRAIKFTEKYEHFIVVECIGPKFNVEKFCEFVGKRLRFELLEFVEKPLAIWVDFCHVFPKMISPSECSSDSEHKNKNLNNSICERFWLVGIELAPNQKANSAFKGKLKTNLQKKFDKKIRNDFERGSFHNVQLKSEVAQRENLRKWRIDPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUV7</accession>
    <name>A0A914HUV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3997.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3997.t1"/>
        <property type="gene ID" value="Gr19_v10_g3997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3997.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8735" checksum="5CE6C745025A43BF" modified="2023-02-22" version="1">MAITSYLLRNKFEEPGNALSKFGYSQSLAQRYKNCRTPSKSLLVACKKKDNLQHDKYAMIFYICMKSETAKRTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV37</accession>
    <name>A0A914HV37_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Laminin-like protein lam-2</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4062.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4062.t1"/>
        <property type="gene ID" value="Gr19_v10_g4062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000074">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000094">
        <property type="entry name" value="Laminin subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000758">
        <property type="entry name" value="Laminin subunit gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000018">
        <property type="entry name" value="Laminin subunit gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000105">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000166">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF435">
        <property type="entry name" value="LAMININ SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037019099" evidence="11">
        <location>
            <begin position="34"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="14">
        <location>
            <begin position="60"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="418"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="465"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="13">
        <location>
            <begin position="544"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="751"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="850"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="905"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="961"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1474"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1516"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1257"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1572"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1522"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4062.t1"/>
        </source>
    </evidence>
    <sequence length="1645" mass="181656" checksum="2C43A0E0983D5748" modified="2023-02-22" version="1">MFDSHRRRLSRQHFLTSVLFLLASFNHPPECAAQPAEKTPSIDPAHYQPSQSACYDERSQPQRCVPDFINVAFNLEVEVTNTCGVRQPTRFCVQTGHIGMGQTSKVCDVCDARVPAFAHPASHLTDFNNPDNETWWQSETMAEGIQYPQTVNLTLHMHKRYDITYVRLKFVSPRPESFVVYKKTKAEDDWIPWQYYSGSCRSTFKLQDKAPVLPGNEAAAQCTREFSDISPLTGGNIAFSTLEGRPSAQNFEESEVLQEWVTAEQIRISLVRMNTFGDEIFGDSRVLRSYYYGITDFAVGGRCKCNGHANRCVKSTGPGEEQLVCDCQHNTAGADCQQCAPLFLDRPWRRATSTEANECLPCNCNGLSNRCFFDAKLFENTDHGGHCIDCAGNTQGPHCENCLPDHWRRHGEHYCRPCQCNEIGAVDGQCDEGGQCRCKAGVGGQFCDRCEAGFYDFGTTGCKDCHCDANGSFNNTPNCSPSSGACACKENVEGQRCDKCKPSFFLLSASNSFGCSPCFCFGHSSVCSAAEGYFAVNMSSQFYENTEDWTGGSDRQLEDVQWAQVDRAAAVSQMDDYPVYLFAPPKYLGDQRHIYNKFIEFFLRVQLPNPGPSKKDVVVVGANGQELVLPIFAQGNPLPTVREQRYRFRVHFHPSLQWSPSLRETDFIAVLSNVSAFKIRGTFSRGDVGYLYNFTVQSAHSIPNGAVSEPANWVEQCKCPDAFVGQFCEACAPGYKRTLRFGGPLAKCIPCECHGHSDSCDSESGSCICQHSTAGDTCERCARGFYGDALSGTAEDCKKCDCPEDGPCMLMGDGDTLCTECPEGYAGRKCDICAEESFGNPAEGLPCQKCDCNGNTDSNAIGKCDTVSGECKRCIYHTTGWRCEMCMAGYWGDALLETKGDCRSCNCYAPGTLRPGQDFEALECRQTDGQCSCQPNVIGLRCDQCAPGFYNISSGNGCQPCGCDPLGSLEGGVCDLLTGQCQCKKGVTGRRCDQCAARHFGFSADGCKGCGCDPIGSETPDCDVARGQCLCRQNVEGRRCDQCSENRFNLRGGCPACDDCYALIQARKNDINGTMSELRENLDEIINNPITVNDREFDEHVQKVRADVETLHEKATKKLEGDDSHIRDQALSLKGQLAEADILVLALRDRLQQIDTNAAVVEGQLDRFGGDKEATHKELSVGVNYVQTQGEQHLTNAQEAFDRYGEKSQQLSGIAGESKQLSERQEQRRREILSLAEQIRKASRQSLSDANEAIFGASSTSQQISALLAEVQELEQRLNAIQQMAVEQSLETNQTHDSAAFILSGVESVRLPNVLSDDLVEQVKKAREEGTEALKTTRSEAEKQSELLGEADKMLAEAHEQLQSAREKQMNVDHSFDEVESFNVRTQAAFDLATKTWNDAKDSHDALSDFHSKVEQSRVDATEEMANLVDIEKEIEEAQATTSEAEEAVGDASQNAKEAAEVAEEAKMKAQNLAMESSKLTDATEQTTVRSTETKNMLDSLSTELDSVLATTKDFENQATSDTERSNEVAKKATLSEATSKSLQEKLSDSDKKLSAALDQLNSLDNVDDDQLDDVEKLLEAAERRYESSGSEAKMRERIRRAETEAVLQKRQIDALAKELENLRQIRDALPTRCYNLINLEQEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVN4</accession>
    <name>A0A914HVN4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ku domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVN4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4913.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4913.t1"/>
        <property type="gene ID" value="Gr19_v10_g4913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="12">
        <location>
            <begin position="349"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4913.t1"/>
        </source>
    </evidence>
    <sequence length="638" mass="71843" checksum="00FD90FC4F8198DE" modified="2023-02-22" version="1">MSPPKRPKVSSVLTADDGNEEEGQMSDGEGTTEAKRKQKATKSKPRQKKAHEAFVLLVDVGCSSAESTTAATASQNDRETDLSRSVQIVDWVLSRKIFTESTDHFSLMFFGHESTSNDDHPNVYVHNEQFDTARIEWLHVLQNEVKSNPKCPGNYVDALYAALDALKLHFDDASSAGNTVTGASVTLVSNLSGLNDAMTVMGEVEDIAARFRAMGCDMLIVGPDLSDDSQLSKSQQLGHSFAKKLLAKIGGGNSYDFREGLSHLKLFIPKAVHPRGTPFALELGKEFAFDPVGWNKDAVEGEQTQQLKKMRRYETVTDEVKAIKYDQIDQASDAAFASMGQLAPVVPSGRFIDKDQITRAFRYGTTIVPFGEEVAKVVEYEREGKQLQLLQFVRKENILPQFIMNCCRYILPAQGDTTAHTTISALCQAMIDLGVVALCRYAYNINSNPRMACLIPKISRETNYPVLIHYLMPFRDDFRYYDFPTIRTPLSKYQLDLMDSYIDALMLYDEGSNVEQLKKQKLHDPRLQYECQLLRDRAMHLDKEGMELTAEDRQKLLETLAPPKQQLDKALIVLDEIREEFPLELNENTRMAAFRTSRGRTEMLGQVDDRLQPIASSTDGKEMAQDWKRELAKKEEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY20</accession>
    <name>A0A914HY20_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HY20"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5165.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5165.t1"/>
        <property type="gene ID" value="Gr19_v10_g5165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000008">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0164">Citrullination</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 15" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="16">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5165.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18360" checksum="6069CB6762E314F6" modified="2023-02-22" version="1">MTEQTERAFQKQPIVFLNDKFRTQGIGKKASNKDRYWKNVGLGFKTPREAIEGIYIDKKCPFTGNVSIRGRILTGVVIKNKMQRTIVIRRDYLHFVPKYRRYEKRHKNMSVHCSPCFRDVSLGDIVTIGECRPLSKTVRFNVLKVIKASGSKKAFDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYL7</accession>
    <name>A0A914HYL7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYL7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4994.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4994.t1"/>
        <property type="gene ID" value="Gr19_v10_g4994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4994.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25241" checksum="76EC0B1651AF5D6D" modified="2023-02-22" version="1">MKCTKLSERLESDENILERLKLKERKKCHELLLELLLPPIRQLMGPRPIGTTNSVSSSCFSSPSLITSHSFHSAAGSESFPLKPLKSNGGLRMGKGQGKQKQHQQTAHKCEQCQKAFRFKSNLFEHKSLHLGSSSRNPFVCPFCSKTCRLKGNLKKHLQVHVTSAEDLECLWKRSFSRNSGRPRKGLPHVPLPKPGDDLGLVPVNIQQQRVRYNQMGPPAAEQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ65</accession>
    <name>A0A914HZ65_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6019.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6019.t1"/>
        <property type="gene ID" value="Gr19_v10_g6019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="498"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="835"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6019.t1"/>
        </source>
    </evidence>
    <sequence length="1297" mass="151362" checksum="BB3D4FA14B4241A1" modified="2023-02-22" version="1">MTSKRVNQSGGPAAKKWDFRTIGNNFSEEMYKLNDHRTEICKKFGFMKNITEFTINPDTPHPDERMRDAIEEMINKAFNRTEETMGRKVKMFGVSLTGTGLGYPVYLPYRPYPQNNADVVMEEINKLGQSGGENGDDMRTVLLSRPMQMNVTCVALPAGEGPRNVHKFDYGFKEHQRIQVNNNDKFCLFYALTASKKYLEVDRFAFNRFIKNIVRQREAAFEILHKSGVNNMENSYGVEHLSAIQKYWDQTFPGKYRIAAFEKCVDPRKSIRVLWKGPMGREAVVPIFLEDNHWDGLKNYVCFFNKGKKFCIDCECFYDQDVRHTYECKARCYYCNRVGGMPCTKERGVKIECPKCRRFFYNQLCYNYHQGHQTCNIWKRCVDCNKTFLFNPKSKHECGETFCRSCGICHDPKRGCYIKPIGVKEEKDIYRIVVWGEQKEHVINYISARVTCTECCDDGSRKECRICGTEREKDWSEAEGREPIKEFLEWILSAFDKKYKTYLFAHNAGRFDGHFVFNYLCRAGKSPMPLINGLKIYEFTVQNSKKHSILIWRDSCLLMPVKLEAMKATFNLDCEEKPFFPYYYNKKENYNRHLPHLPPMEDYSPGSMKKEKFDKFEKWYNENKETPFYLPEELKNYCRNDTEILLKSIVEFRRILVKDITGGFDPLPRSCTNAGVAMSIFKAMFLQEEELSIVPERGYERCDRASVIAIKYLEWRSKRDNVDIKHAGNGREEQVGKYKLDGYIENGGGRSKCIEVMGCFIHGCLKCYDPTAQLIGGRAAQDLYDDTQERLAELRETLDVEEVWTCEIEQELKRDAEMKEFFEDRGNEKGPIDPRMAYAGGRTGPMKLFAKADEKKKISVYDIVSLYPAVNYETAYPTRLPDIIIPTRDEIEVSWTKPEDLKYKGLYKVRVNPPKGLRIPVLQLKCDERLLFPLCWRCASSFKKENTRCEYKCPHDESQRRYVATYTSVELAKALESGYTVDRFYRAWHYGEDNDDLFKGYVRLFLKLKEEASGFPKGVETEEQKKKWAEEYKEKYGIDIDLERVKKNAGLRYISKLMLNSLWGKFSMRNSLCKNKVIDQASEFYGLVCDHKIEIHDIVEYSDGAIRVVYKDKEDFVTEHSSSNIILSLWTTSMARLKLLDYMQEAERNGGEILYTDTDSIFVMHDRDVEPITTGKYLGQMSEEYGGYEIEEFCCGGAKQYGLKMRSKKTGDVDYVMKIRGITFDVDNHKTLHYEAFKKMVLSYGEEMDPAFFVYKNDFGPTRESKVVTREKHKMYMPICQKGIIDEDFNVLPFGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZM5</accession>
    <name>A0A914HZM5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZM5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5254.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5254.t1"/>
        <property type="gene ID" value="Gr19_v10_g5254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037907820" evidence="2">
        <location>
            <begin position="21"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="675"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5254.t1"/>
        </source>
    </evidence>
    <sequence length="915" mass="98428" checksum="99DB84F215D83A2F" modified="2023-02-22" version="1">MCLCFHLFVSLTIAPFYVIGQESYGAYAGLPAEGVNGAGIAGNGANSDREGEITRGASIRKAPIAPVAPPRVPLPFSFGEDEEIPGYRKAPPPPTRREVRSEGQCQFDSNKWRILPQSAVANAIMFDRTSGIQCNECLDLCTFKYQDPSNAWICRSVTYDHRWKICDLFAVNGTTKPYFLVDFMGRDYFDFLAALPPTDSQLKGIHGLPPAEVGNAAPPSQNAVINKNGQQALVNLAERDASKAEDGTRGEDRQCLCPCKLLADKTAHFESEVGNLTEGNTDEVNSNQLPLAPPTQTPPPADPSLVSVPIADAVTQNATASTVVSSADESASVAAPPPLELAAPIPPETLSINSSSTTAINATNVENKSEDGTFPSLPTDPNTSPPSTPSPPLPDTSSSPSPPLPDTSSSPSPPLSDTSSSPSPPLPETSSSPSPPLPDTSSSPSPPLPDTSSSPSPPLPDTSSSPSPPLPDTSSSPSPPFPDTSSSPSPPLPDTSSSPSPPLPDTSSSPVPPSADANVSLQISSNSSFSESTGHRALSSKTFQQQPFREIRVPFHKTLEKLNRMGGSPSAKRPGKTHEPKACPKKGQLAHYVEVSDHQRLLTARRGGTNSIEEIGAKDVVECMDACDAPIRLSNCNSAVFSTAHRCELSSSAANHSAPDSLLAAPKFKYVEKICLDASLSRGDDKRRVFPAAIGYILVGHVQEVFNAVSLSECIKACLIAESSYGFVCKSMMFYPTDTDQNCLMNSESRYSQSEVFVPEDQNVHMLYVDMEQPRLPPSPLPLPEDERRRLKDVPLGGRPGKDIDEEWTRWSKCVNSPASMLPEMRHRYQKCHDTKDVRKCPKESVPCRKMPKLLRIQRIWNASFPSETAVTNTAEGRRTSNCLAVKDALGLKRCPFGMRWTGTQREFCSKPIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZT3</accession>
    <name>A0A914HZT3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium uniporter protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZT3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5590.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5590.t2"/>
        <property type="gene ID" value="Gr19_v10_g5590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5590.t2"/>
        </source>
    </evidence>
    <sequence length="341" mass="38276" checksum="A754E202C5926467" modified="2023-02-22" version="1">MAIINYFTITSVNQCHWGLSIVFTFQRDNAKVNANANANANANANANAMPMPHHKINSFPHHYILFILSGNNIQPSLGTTPSQQAIIGQSLELLQKCKVTLANGGDCSKHLNEQMEAMLLGGCKLAKSEPKLDDADRNCKALQKGGKQLLDDKSLVEKFQTNGLHGTLAEILSDPKNSKSEIVRFFVSLRKLLRLGEEKMSAGRTKQILNNVLAKNPVVIMPSNVMELMIHLWTHNRSDGDYHPEVRQDAARNRRKRRNNELAVNGAVFALVWVVAYLIVSFLHGASSMVGELLDYGFISLALSYFVFAAFIRQQRFYRRGAASFENYLNNRGFQTRFDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I151</accession>
    <name>A0A914I151_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hcp beta-lactamase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I151"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5909.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5909.t1"/>
        <property type="gene ID" value="Gr19_v10_g5909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040239">
        <property type="entry name" value="HcpB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5909.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31798" checksum="CAABAC95B4057CAD" modified="2023-02-22" version="1">MHVDADKMTFICSFVLNASPMPLPWSKKKRPGDDEVLESGMTMTEIMDERKEYVNNIGIEYRFGCYEEKRADSCQLLGEYFEAVQTDFKAAFDVFRSNCEQRQFPRSCFKYGQYLAAGKECEPCFKQAIPPLRMSCDGGIYKGCRVLALILWNGEPDRLPDSEQAEQLMRRAAELGDHEASWILSTWYMGSSAKLKREKTVRSDHKMGALSRDMEKALSYGLKACDEGDIYQSCLNVSRMYRLGDGIPKDENKAKQYNARAKELHRMIKKGWNAGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1J0</accession>
    <name>A0A914I1J0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleoside diphosphate kinase, mitochondrial</fullName>
            <ecNumber evidence="4">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion intermembrane space</location>
            <topology evidence="12">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 15">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914I1J0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5745.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5745.t1"/>
        <property type="gene ID" value="Gr19_v10_g5745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000017">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="16">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5745.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17970" checksum="A54022BC75233218" modified="2023-02-22" version="1">MGHFDKTNIFIEKLSGDGDVADGLMRFEQITTNPSPIGRIIARYESNGLRLVAMKMINATKSQAAEHYRDYRDKPFFPKLINFITSAPFVGMVWEGTDSVRRSRQLLESAAVSGNFRNSSDESRDIVRHGSNSVEDARRKIDIWFSQNELSIIPTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1M6</accession>
    <name>A0A914I1M6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1M6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5770.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5770.t1"/>
        <property type="gene ID" value="Gr19_v10_g5770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037802665" evidence="2">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5770.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="27587" checksum="ACEEBC08F83AE1EF" modified="2023-02-22" version="1">MKLLFLSLSFLLFAGNSVVGDGSAPPYNPKPPSYGPPPPPPPPPSYEPPEPPSYKAPPPPPPPPPPPPPPPSYEPAPPSYGPPEPPSYGPPEPPSYGPPEPPSYGPPEPPSYGPPPPPPPPPSPPPPPPPPQYEPAPPSYGPPEPPSYGPPPPPPPPPSPPPPPPPPPPPPPSYEPAPPSYGPPEPPSYGPPEPPSYGPPPPPPPPPSPPPPPPPPPPPPPSYEPAPPSYGPPEPPSYGPPEPPSYGPPEPPPPPPSPPPPPPPPPYPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I210</accession>
    <name>A0A914I210_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I210"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6770.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6770.t1"/>
        <property type="gene ID" value="Gr19_v10_g6770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6770.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15787" checksum="5D9DC167E807B954" modified="2023-02-22" version="1">MLALKCTGTEVWALKCASLKREARGGAPATVYYPSLPRCAVGDSLALTRLKRSADKLRCGGCEMRGHQQKKTEGQGGNDFNKYARNCACLCCGCSMHGVWESMNWSTSALAFVQPRSTARSFCFTTRQNASSSLSDYGGRKLFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I218</accession>
    <name>A0A914I218_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I218"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6590.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6590.t1"/>
        <property type="gene ID" value="Gr19_v10_g6590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6590.t1"/>
        </source>
    </evidence>
    <sequence length="612" mass="70520" checksum="2F3F4CE1BF18E98F" modified="2023-02-22" version="1">MKRERLEVCDTTTTDTPSPRPYKRPKESERRSFKTEQLEEVNNSPQTHQRWRHNTGKRRALDREFATKLASITLISGDLAKLDTIYGGAYDDAQLEQFSRAVSGCLCRLGRHAVGQKSEVIAFIDAVVGPVDLHQMAFSQRRIFVFQLGYFEFDQIADQKPDLVDYGPWMADMDIQSLPLPSDEFISEKAQMLQSLLAFDTSGQQIERDHFTKSERSEEPCRGIDQQDAADDDDDDDVQILDLETASSTVKTEASDARDIGDDMEEGELLEDDADEVEEEMDDEPPLDKLVHSIESLRRVRLMLCKVRPRNEAICECLVGCLVVCHTKNGTAKVIVDEIIQVDGTKIIFKHLSTPYLISELVDHEITDNIFRNWIDNMARWGEQLPLSSLYHARRLRVYEKLKAVKKSLKSAKNQRDKQRKREKREKARQQAENNEHHQQTKSKKDGKEADDIDELNSRNMFRKAFGSVIEKIMVTPKHLVQLLQRGRTEFERVAVGLYVQCTVTMGGKKRQRLWLVEQIKRISWNAKPYAMYGEQLTVLLHFDHHCCTVNAVQFRKPEIIKKLVRQQKLAANFISPSGEHILRKSEELQAALRDTVRLTAHPFQKTKTDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2Z0</accession>
    <name>A0A914I2Z0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Papilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the papilin family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7014.t4">
        <property type="protein sequence ID" value="Gr19_v10_g7014.t4"/>
        <property type="gene ID" value="Gr19_v10_g7014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000017">
        <property type="entry name" value="papilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1172"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1233"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1353"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1462"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1556"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1613"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1765"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1824"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1907"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="1995"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="21">
        <location>
            <begin position="2130"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1297"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1412"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1690"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1824"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1299"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1426"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="163"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7014.t4"/>
        </source>
    </evidence>
    <sequence length="2170" mass="237545" checksum="00A4083C3AB10061" modified="2023-02-22" version="1">MAFERCKHWQYKERPHKVPSFCDNIALGLVGILTGLAFCLDTTKMRAQVEMTSFSAAHWHFVFLLPLLLLSFVPLIALASASSEAADDGAVPLPLHPSSPPHRQPAQQNRAKRQAYQVYLGNEVSVSVDRGQVVDEGPWGAWTVERQCSRTCGGGVYVERRICGGGGHCAGPSIRYISCNLEPCPADAIDFRAEQCAAHNDDPLDGKYHKWVPYAGKNKCELTCRPESGSFYYNWAEKVIDGTKCDAYGQEICVDGICLPVGCDGKLGSEAKLDKCGVCQGDGSQCKTVEGLFDERALPSGYHDIIALPAGATAIHVEERRPSSHVFAIKNATGFFFLNGNFQIQVLDKDIVAGGAPFKYGKGDSGTERLTAQGPLQEPIIISLLLQHTGAKQIAVKYEYSVPLEKDVKFLYKPGEWSQCSVTCGRGVRTRALYCIDTATQARVDDASCEEHNATKPEFEKKCVTVDCEPEWFVGKWEPCSTTCGDRGVQFRVLYCHRVFADGRRITVSDANCTEERQLPRPDMSQQCARWSCPEWQAGPWSACSSQCGDAKQFRSVTCRSAKDGEEGKLLPAEACTGSKPSTERDCNLGPCEGLRFHTADWELCQKCNDTEETRAVNCVDKNGREYPLEKCLDGKKVTKIPEDTRPCASQAPCIYEWHTSQWSKCSTECGHGHTQRKVFCAINELGQTKRVDEALCGQSADEKPVARDECVNEEKCTGTFFTGPWTNCSAKCGGGTQTRTVVCLNYDRKPVPEWCDEKEKPPEEQECGMDSCPKCADSEHGCCPDEETFASGPFLEGCSNCSVSDFGCCGGDNMTAKTDEAGTNCKEFTEPLGGEEGSGEEPVDAEASSPTDGKALCEIVNQDTMEKFQIPCADTVLAAANETVELLKMAEDEAIGGTNATDGEKHCSKSEFGCCPDWSTPAEGPNYAGCPKFVLGNCNGTKFGCCPDEVTMARGLDFEGCGEPTCAASLFGCCKDRRTIAFGPHYAGCDRSSFPCELSPYGCCEDGETAALGNNGTGCGASCLLTKFGCCPDGKTHAKGTHNEGCGCEYAQYGCCPDGRKAATGPGFYGCPEGCAQSKFGCCPDGKTIARGANKEGCPCQYTRWGCCQDGETTALGPLNEGCDDCRYAKYGCCLDGVSKAIGPDYAGCPTTTAAPFIIGGTVSPTQIVSCSLPQDQGQVCHPGYQLVWFYDIAEGRCSQFWYGGCAGNNNRFANREQCEQSCIEPPHLGRCYLPKVEGPQRCTQLAARYWYNYVTKQCQAFWWRGCLGNANNFGSWEECQKFCELADATQVQVVMPQPQPQQPPQPPQQQPPPVAPPPVQPQAIQAPLQPAPQTVAILPPGLEEAGELDSCRLNVDSGNCQNYMDQWFFDPYSGACFLFIYSGCGGNRNRFGTEAECIRQCGHLRKPKPGFLGQKQLPPPTPAPTAVAVPPQQQQQQQHKPKVEKMTTGRKALTKSRDVCNLRPDIGKCEGHFESWYYEVASGQCEKFEYSGCGGNANRFNTPDECQAVCLRRNDFPSPQRPGGSVSAPAPLGPGNLEQSLPIIGDKQHLAHICDVPKDSGACKTFITKWFYNMRDGTCVRFHYGGCDGNANRFDTEEQCKNTCGNYKDTCHLPKVVGPCEGHTPRFFFDLHNRQCLPFEYGGCLGNNNNFRTLEECQARCRPSTTTTNPSPVRLTRANPMPVTTAELLEDDDDNDQNRRNDQTRPSQQPGGDQNDHFDQSAVNGGIVNEEEEQDEQQQQHMDEDMVVVPREHLLYGQLPELCLLPEQRGTCFGEQLRYRYDTSAGDCVGFLFSGCAANANNFASYEACARACGPWKAEPVCEQSPDEGREQCNNGRRRRRRRQNDMAGANVPKWYFNAALGKCALFFWSGCGGNGNRFQSKSECENLCQREILARTHRRTGRACAQTMDAGPCEDLVTMWYFDAVQEQCRRFTFGGCRGNANRFVARADCESQCVAAVANTSGDSHLNANDNFGVPQHLSRQSAHRHQHRRPRLFAFPVGTLLVGTSTLTLKCVADGTATPKAFGGNEANGEEEEEDNNFTWYKDNQQMLTTQADDATEQQQQEQRVKFFESVTTHAGGGEAAVVGELRFRSVRLMDGGAYSCAFGDASNALISEPVIVRVTEADPSLTLCPGDNGPAHICRTVARTGLCSTLRYGRYCCRTCAIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I371</accession>
    <name>A0A914I371_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I371"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6890.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6890.t1"/>
        <property type="gene ID" value="Gr19_v10_g6890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF28">
        <property type="entry name" value="BAND 7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="86"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6890.t1"/>
        </source>
    </evidence>
    <sequence length="479" mass="52130" checksum="79C863FA5510ADAA" modified="2023-02-22" version="1">MFWWCCADFSNMAGIFGVKKESEDERRRRAKWRDEQNAMPNLPAFSLITRNSIMAICTETTLGTFPCQFCLVPSERCRIVSLSALALLKFIGPSERLVIMRLGRTKGVHGPGGTVLVLPWVDKATCVDLRVSTLELPVIQSLTADQGMIELVATVFSQVTDPLLAHCAIQNVKETLHSLAYVTLCRQLCKRLLCDLTQTTSLDNILAKCQEELNMFVRPRGVAVERLAVTRLNVLKPADTGGSAMSVLHTLARSQLGQQLFGQLSRNFLVGQQQQCPLDTTAAASGAIPEVIIDNKKDGHGQQRVTPTALSPICEESVDSSAFIPHALDSDLMALLKRIRPALGPPLVQRVQRLFRVRCAGDGSASASSITASSSCSTTTIAAALPPEFDIDLRSGDGWCGWTWERTGPLPPCDVHFTLQKCTLLSLVDGSVSPMCAYLDGRVQIVGSVQDATLLKHLADALVALPKRGRTEDGEIVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3N2</accession>
    <name>A0A914I3N2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3N2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7011.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7011.t2"/>
        <property type="gene ID" value="Gr19_v10_g7011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7011.t2"/>
        </source>
    </evidence>
    <sequence length="224" mass="25330" checksum="71EA2DBB9BEE4C96" modified="2023-02-22" version="1">MLNIGVTGQLCSELERFSISLYWDQTLTKRIQSKPMIESTKLTINDNTDDGAVGTETWPSLKSPSSLVLIAALLFNCYRCCPADVLSLQDNACAKKGAGLPTGFSLPKDDQLLMEPWALGTDDINQPIQSQIHALLSNVEESAEPLHFSIIIIERDQKTKHGTCSHSSILIFCCRNCQLFVWRNVTHERALHLQSYAMRDFYYYKLFQAIATYVLLWQMADSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I533</accession>
    <name>A0A914I533_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914I533"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7389.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7389.t1"/>
        <property type="gene ID" value="Gr19_v10_g7389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000429">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="123"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7389.t1"/>
        </source>
    </evidence>
    <sequence length="519" mass="58268" checksum="59AC694A513D8AC3" modified="2023-02-22" version="1">MHCPSIVGVGGVSGVSGNSPTNCNANAATAEHKQLTIAHLNVAQMVRQQSDTSSDRLITLRNKLNRSPAFEHSDNHRPTTSAACLDPGELHRPSKLSADNDAIQTNIVGMVDGDNSYIQLNQYRFMEEIAQGSYGIVKLAYSEQDRNLYAMKVLDKLKLVKNYACFKPPPIRKKSANPLQLAVHRNPLQLVQREIAILKKLSHPNVVKLVEVLDDPQDNFLYMVFEYVEKRSLMDLPTDSPLCEYTAWKYFRDALKGLEYLHFQKIVHRDLKPSNLLLSESELVKIADFGVSCEFEGIDAFLTGTAGTPAFMAPEALSENSSQFYSGRAQDIWSLGITLYALVVGNVPFWDKYVIALHKRIKTQPIAFPDSVKMSDGLKELIVGMLRKDPGLRFDIIQIKEHPWLTMDGRRPMPSEEENCHLVEVTEQEVTESIRVMPHLGTLILVKAMGRKKHFGNPFRKFQQNTNSFRSRRKSSSLRTPSTEEATNLLNILKLSSTESATVSPNLRLNGGEMAEKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I577</accession>
    <name>A0A914I577_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Runt domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I577"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7425.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7425.t1"/>
        <property type="gene ID" value="Gr19_v10_g7425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF31">
        <property type="entry name" value="SEGMENTATION PROTEIN RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="42"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7425.t1"/>
        </source>
    </evidence>
    <sequence length="534" mass="56745" checksum="5587D52384330AD4" modified="2023-02-22" version="1">MNSFRLQLPTAATTLFPPSSSSLLSKCEAEEAEQDLALNRAEESMRRIAGQCRLQKTAHPDLFCSTLPTHWRSNKSLPSPFVVLALFSVPDGTRVTVSAGNDENWLAEVKNGQAEMCGQMARFSDLRFVGKSGRGKNFNLTLTVHAHPLAQVVVVPNAVKVTVDGPRDSRNASKYQTNVQYVPRKLRSSLELDGMVAQFKKAPQQRHVIERPAHFVPNFLMPRHALLRCPMQQNNAVAAPPQFPPLCAMPPLPFMLPSSTALSSLALLNCNNSNNNNHGGFRQSNGTSFLAAKFASGIMPLATSTPQGNNVTSPPPHASTPSAFRTPPPILPDMKMAGSNDVNNNASRLGNLPPGVFPSAACASANGGLFAAAAAAAAAMFAPSMSGTGTTITTASASPAASLLAAAMNAAVARQQQQQKWTTERTACTKGIAEVVNVGDSSNETSIDKQQPSDSNCASSTSTADDEEPSRKRSKCENNNCDKTYRGTAGNEEMPSKVKEGFNFDGEIADGESTGTNLSPQGPVAGGLWRPFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5L4</accession>
    <name>A0A914I5L4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5L4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6992.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6992.t1"/>
        <property type="gene ID" value="Gr19_v10_g6992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6992.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="26094" checksum="22EA9536335807D4" modified="2023-02-22" version="1">MVENGTRAVQMCGQFIHCAQIIRAAEAAPPSSAVKKKDTFAPPQFVLSSQPTTTNRTPSPKTNKLQITQSPCLLPANLFINQPKLAAVSVVTTFCQICHSKRFEASQRIKARRINMVVSGPPQSPRTGLALTDLQQSTSASIDTSNSGNGSGSSGSCSGSIGGGVISGLAIAGHGGSSNWSTRGVGGIGAGLSCSSLSSVGGGLFGVKMGGGMDSLHSGGSPSLGQGSFGGFPSSSNGTNGGLFNNCGCSSSDYGLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6D8</accession>
    <name>A0A914I6D8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Letm1 RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7042.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7042.t2"/>
        <property type="gene ID" value="Gr19_v10_g7042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="3">
        <location>
            <begin position="161"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7042.t2"/>
        </source>
    </evidence>
    <sequence length="360" mass="41007" checksum="3390A0420A4659EB" modified="2023-02-22" version="1">MIVSSSSAAFIVARAVCRRCPSVLAFSNLRSSFPASPSLFVVQQRAFASEPVANGPKSGGSVVGVKKRYEQWLECSYPRVYKLYRLSVDGSKWCFYDLKTFCWLTYGLRIGRITLSDLNANELFVYIQAGSQLVKLSILAVLAVVPFGFPLLIISMIFAPKYVLTRHFWSDSQSQQFQASHFVRNERKLFPVIVEALKQRDSSAPIGKLPLSLEQLIVKKTVNIPNSLDTFPWQHRLSLKRMHHLPLWATDGALLKHINLLQLLDKEMAQDKGSVETLSLRDLQTHLYLRNLNFARMNVDQMRVALVQWLGHFKDLSSCDPLLYAHVPVLTQANSDDLERWKKAVAAKADALKITEWWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6J8</accession>
    <name>A0A914I6J8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6J8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7089.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7089.t2"/>
        <property type="gene ID" value="Gr19_v10_g7089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7089.t2"/>
        </source>
    </evidence>
    <sequence length="713" mass="78329" checksum="1ED375DC00CD3AD5" modified="2023-02-22" version="1">MASSSAGGMGGISTISTKNFEASEFEFRKIVEEFILSNKGAHYNQPIHCRRRFSRADGVGPVPNSDRSIDRSNTLTGRADIAAALKCPGIQMLKVWRIWAKQWPNSLPAFCPLWPAQNVDMAILARTSSTAFVVGIGSFMAYKLFCRMARSNCLWTTLDQLVQQRTLATLVDPSSTSPSRTVELTEGFYAVRLGGENELLRKLDECLCGKDSASTDVAGTARQDEKVAVVQVRHGSTLRRLIRQNKRVQREGIEALQQEQNATEGILMRGERRHKQERDDDEESMISGISNLTSASRIKPNPHAVERVPPLQLPQEDESAAVTAASSSAVSTPMSALLHCPNADEELCWENEFSSASEAGDAVDARQTDDEMGEPEGLFLFRERCNSLGSISQLSAMKNLERMFRGMPDWHAEPNIDECHLVGTQLQQQHQLVDTALDNLRDLDRLESATNVSSSMASSRLARRCWLETEDGTNRPAAAAFPREAYKIVGPKSDFDFSEMSSICSRSQLIAAERGRKQQQHFSACRSQGLWELCGADVDRRNSSRFSSEKITIGASGDDGTEQYQKHQQQQLLTPMSSTGISSSTMVDSVISCHSSLASTSAFSTRQRSCTDDGAGGGDAGVMFDSAIVSDSAQSNLGLGDGIEHENEDDFDGLSRLAKDGVIRRFCPPNAAAQISDHSTPVRQYQKRAVAATQQRRRGSSAHGSENSLEWFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6N3</accession>
    <name>A0A914I6N3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6N3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7993.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7993.t1"/>
        <property type="gene ID" value="Gr19_v10_g7993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF173">
        <property type="entry name" value="FRAZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="131"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="246"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="345"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7993.t1"/>
        </source>
    </evidence>
    <sequence length="805" mass="90123" checksum="9EC00CBF24267769" modified="2023-02-22" version="1">MIDYLLCLVGGVEGFETGYGELRTDSFWRIAHGGLRTVENCAPAKKEENCALKLRTNPENCAPRCAILLFFLLVRNSPCAILLFFLVVRNSPLSPNTAYRVRIRFIGDLSRSVWSAESEWLRTMESAPDLPPTDVQLHPVDATSIRVKWKPLTREAWNADRVGYRILYRVYRLDFVRSPSSQANGTLAEEIPLSAIEQKESMDVLLKGLKSFESYFVQLCSYNVLGQSALSEPRTIVVGYAVPKQKIHALRVEPISSTSFFIQWDAWEANERDLISGYRLRWTPTKQHSHSEEVDELILIEQNEHTLTELQMWTEYQITVSGYNRAGDGPVSSILARTLDDVPGLVGQIHFRDILLDSVKLSWAVPTEPNGQLTGYVVLYRTLRNNALGTVGIGDLFPRKEVQIRTTRPEASLDGLDDNSVYFVSVRAETAAGTGPEVTANITTGYNNDAPEAPTQIRLVPEQQCVRIRWQNGAPGDTPIKGFLIQTKRIGTSRYDDVHQNGRRLHRSIKPEHLKHVIGHWNTVGLIEGDYGTTEWRLSYRELEPASFYVFRLFARNNLGVGKASVNSEQLHVPASIPDDPFYSQWWFQVVVGALLALVMFSFIVLLFCNNRSKKNDAVANDDDGCRMAQKAKNKKKKNHRRVGEGDAFDTLQLSDGGIVSYELCAKRSERAVGELFTRPTTKQSWVGSLEPSTTRQKRVGGVQQQVPTDIYTALSTDAMPLNSGGGGRASNEPNYASNGMERMASQRQSSSPYFQLRHFNAEYSDDPQISRRPCAVDADCIGDRRSASEGTDRHSNGGGVSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7K3</accession>
    <name>A0A914I7K3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7K3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g803.t1">
        <property type="protein sequence ID" value="Gr19_v10_g803.t1"/>
        <property type="gene ID" value="Gr19_v10_g803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g803.t1"/>
        </source>
    </evidence>
    <sequence length="597" mass="62855" checksum="AFE1DAE9EC936395" modified="2023-02-22" version="1">MDNNNMDNNNMDNNDKQQLQHVQHDHHQQQRRPSMITAHVQMRRASSAEQLAADASTDDAMAGAVAAGASAHLLSRPLRIQIPEIDQQQVVKLESREPLMACQRLLQADAQHQRNTRVPNRKFVAGGSSSTETAATAVGGAAGTAPNCCDPGGFSAANHCCQIGCGTTPPISSVAERFVLQQHAAGGVPKKKPPQHRRLRKYASETSFCSSPGTSIGSASGLGLALAVQQQQYAAAAHQRMPHSARACRTQLQQSREQLLLLDDDTPSPPLIITTGMPLIMPISTGADREVRSGTSGRIFHVRGSGGGAPVMQSPAIAQLPAGGCGAGGRGGAVLTRLQQQQTPRRGCSGGTTPTTTMTGAGAATLRHDSADEASAASMGSVSTVGSGAAPTPQMQRRAATIAAQQLQLTQQQQRFKMRRPKSTGQIIIQQQQQQQHQQMAQNHRKKFSEIQPQHGAAMQDRNSVGTAGTGQSGGSGSLTLAPGGGGGVGRVHQQYQNMNTTPHQQNNNNNNASASNMTAVAYDPSYTSATVYSDSITCLNVAGVLQPGAGGGASSCADGMTDHQRRGSNYYFLEDDSTHEFDDEGLFAVVLVRVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9J4</accession>
    <name>A0A914I9J4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g7868.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7868.t1"/>
        <property type="gene ID" value="Gr19_v10_g7868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000131">
        <property type="entry name" value="ankyrin repeat domain-containing protein 17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND KH DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="725"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="773"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="806"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="841"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="875"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="908"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="943"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="976"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="1291"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1126"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1238"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1380"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1066"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1177"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1244"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1380"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7868.t1"/>
        </source>
    </evidence>
    <sequence length="1647" mass="178324" checksum="22F45CCEC23B600E" modified="2023-02-22" version="1">MAMKDLFCLVNAFINRNKVTEDNQKLAVPIEAAEDTRVLPGSSSSTSKQLLPDLCGMDMNQQKKLHKALYSAGVNAALSLEKFVCEVPKKRVDNTGSDETFPEDFDVNEVLEHLNKSAFDDASKTFRMMSNNMEEIMQKMNAAALAAFASATLRKPPTKHVENLMQTSQENGHPLLVDEDTSDTDPILSREMKRDPRPVFNCHCRGIGRRRRMRLYVCAAGYDDLAKLLISMRNSAEFVQQSDSTPLMESCCGGHSDVVRILVQAGADVNALSSTQNTALIYACASGHIECVRELLATGRCDLTIRNEAGHCALMEAANIGNVEIMKALIQHGAKVTCVVESVEYKESPLTLAAFKGHYDAAKYLLSLMSETKNEQEEEELYTALIEASMDGHVENPLTLAAGGGHNEMVKLLLDSGADLEEPNDEGYTPLMEASREGHLDVVELLLNRGANVNAKIEDGLETPLTLAASGGFKNVVELLVLLGGDLTIGERTPLYEACQEGHEEVAQFIVQHLRKSYSLQVVQKDLNEALLCTAGIDSDSICDLLIENGAQIDCFSKENRTPLMEAARQNCTKVVELLIKKGADVNKIASPCVGKDVDVGLPKSKSSKKLSQKDCCPTLKCPCCVPPSLKKNAKEVCTAAGIPPAPFTTGHPNAAKKPAPSRSSTPSQNKTTTTSAKSKFATPLANNATVINKTQRSLSTSSSSATLSDPSAWLDNSTTSDLQNNDTALTLACVGGHAGLVDLLIKRGAHIEHLCKLLIDAGAQLDAQADRTKDTALSLACSGGRKNVAELLLKNGANKEHRNLSDYTPLSLAASGGYVDIIQLLLSNGAEINSRTNSKLGISPLMLAAMNGHEEATRLLLENGSDINAQIETNKNTALTLACFQGRTEVTRLLIQYGANVEHRAKTGLTPLMEAANGGYVDVGTILIQSHADVNTSPVPTSRDTALTIAADKGHAAFVGLLLRHEAQINARNKKGCTAIWLACNNGHLDTVHVLVDYKADNEAQDNRKLTPLMVAFRKGHSKLVHFLLQHVTQFPSDSDCQRFISTLTDQELIEKCRQSVLYISEAKEKQAEQANKAAQSLLALLAHEEALEESKKRSKQRQKEKKKMDAEVVLEGQIVKSAEKKAETAEIIPKQLELPTKTGRISPKSSPKPNSTQNSKQPKCSSSSTKEKTSQNTIAQQVKKTQNSPVEPSAKNNTKKALAAATLGQQNSCIFTNVEEEEWLRMNKKLASIKMTESNKVTASAISVSSNSSSAKSSSSASSTQQNSVSQPSSEEQLFSELAVLAGRRSSLQVLNIAANAIARVIGRGGSNVNAIREATGAHVEVEKQSTRKEQTTRKITLRGPADSVRNAMRMIDLLMRDHNVLINEIVDRVMASQRKSPSLSSSSETSSCQPLQLQPAGTLPSSVPSSPMVINGGKAPEEALKKLPSHSIGSRVVGAAGMAPISPLIALQTQSVPQSDSQIFNSPTTNVWQKRAEAIREKKAVLNEHPTHRLVSPISPSNSSNCQSVDLRKSGYAPALPITVEGEVKFSLNAEELAILSKEEHQRKAPGYARPLSSASSTNQQLALANMKAESSNASTLFDVLTSRWSTNPLESAVGNDSSNNGDSNLQNSWSYLLEYWKNYRQQRFTNQVSKNDPYYSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9P9</accession>
    <name>A0A914I9P9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Activating signal cointegrator 1 complex subunit 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7988.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7988.t1"/>
        <property type="gene ID" value="Gr19_v10_g7988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="178"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="425"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1067"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1250"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7988.t1"/>
        </source>
    </evidence>
    <sequence length="1879" mass="213782" checksum="26A0DFAD7A759ADF" modified="2023-02-22" version="1">MDSEDGIDDGLFTSHLKENIKKDQKVAEKIFNYSTNNETGPSSSTSNFGAQNFQPEFRPELILWRNKFYEVDEEEDEQFAWDDVLRKAERLNLSDPTTSEGHKTVNVRVGETKMALPEGSTSRRMEHCDELFIPALGAGNKAFLDNFPRIRIDTMDEFGQRLFEGIESLNVIQSQVYDRAYNSLDNLLICAPTGAGKTNIALLTAAKTIKDNVNNTTGRINKDAFKIIYLAPMKALASEMTKNFSNRLAKLGLKVRELTGDSQLSRREISETQMLVLTPEKWDVITRKSDDEELSQLVRLMIIDEVHLLHDERGPVIESIVARTLRQVEVYHQNLRIVGLSATLPNFEDVAQFLRVDSTRGLYHFDARFRPVPLAQSFLGVRDSDSAGAVLQREREKALRRGEKPPTSVPQKQLMSQKEKIDEVCFRQCVHFLRDKHQVLVFVHSRNATGLLARTFMAKAALANQREIFEVEQARATTNSYLKATKAMRNAQSQELQQLFQGGLGIHHAGLVRHDRHLMEKMFAEGAIRVMVCTATLAWGVNLPAYAVIIRGTEIFDPQRGVFSDIGILDVQQIFGRAGRPQFEDKGHGVIITTAQKMAHYVQMFHRQAPIESQFQSRILNNMNAEIARGAISNIKEAVEWIRFTYFYIRLRKNPLQYGVEWKELRREPSLVTYLTDFCHVAARRLDLNRMIRYDPLNEFVSATDLGRIVSHFYITFETVELLNNETGPVRFTELMTDEMIIALIACSSEFSQIRNRDSEMVDLDELASFGAPLKIRGGLATTAGKVNCLLQSHISRAMVSNFALISELYYISQNATRIVRALFEIALRRCWAQTTEACLAMAKCIEKRLWPFNSPLRHLADIDAISFGTVQKIENRGLNFFALFDMSPKELGALCHADGQTIYNAIRMLPMMEVEAKIRPITCTIIQIEALLMPSFVWNNALLGSAQHYWVIVEDSDANIILHYENFLLTKKIALSGEPQRLIFTIPVNEDQIQHTYLLRVASDQFVLDDTVVPLSLARSILPSAIKQHTDLLDLDPLPLSALGNPRFQSLYTFEFFNPVQTQVFHTLYATDENTLIGAPTSSGKTLCAELAIFRLFNGRPGKKCVYIAPLKALVRERVLDWEDKFHRKLGHSIVEVSGDNTPEVHELNQASILITTPEKWDGITRYAEAKRYVKQVELLIIDEIHLLGVERGAVLEAIITRIKSMARRRELAKLPIRIVGLSTALANAGDVAEWIGLCPCRMALMNKPAYQYIKQFSPIKPVLVFVASRRQTRLTAMALLGLLQREGEHSHQQWLGMDQTELERTLTHVRDDNLRLTLTYGVGIHHAGLHVAERALVERLFVERKIQVLVATATLAWGINVPAHLVIVKGTEYYDGKTHKYIDFPVTDVLQMIGRAGRPQFDTSAVAVVFVQDTKKNFYKRFLYEPFPLESNLLPVLANHVNAEICAGLITNRQQVVEYLAGTYLYRRLFANPAYYGLEQLNDKELTTFLSTTVDQCLGELGLSGCVVLDEEESGTVDPTPLGRIASKYYLQHLTMRHFKARIHGAMSVEELLQCLADCPEYEEIPVRHNEDQINSEIQSFLPIKLSSSDWGSPHVKANLLYQAHFSRMKLPVDYITDQRSIIESCIRIIQAMFDTCLEFALLDTAINVLVLLQQIYQARWYSDHPLLCLPHLSAHSIDGIGPFCSIPQLQHQLGIYALDNVDAMKKSEFERQHIRKLRKNSILKEFETKELLEGLMRWPALRIENAILQDQLLEKAVDLKAEKMEQLELRCGHLFKLRLTLRLHGPSRFQSDAFCPKYPKKRRAGWVLLMGDAMSKQIWSVERVPPWDRTTDNKFVRLSFSTPNEPGFHSLIILLMSDTYLGIDQQYSLNICLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9U8</accession>
    <name>A0A914I9U8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl peptidase 9</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9U8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8625.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8625.t1"/>
        <property type="gene ID" value="Gr19_v10_g8625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="2">
        <location>
            <begin position="153"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="617"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8625.t1"/>
        </source>
    </evidence>
    <sequence length="834" mass="93037" checksum="251EBAD2DC0E4E25" modified="2023-02-22" version="1">MSSFSESTWDGYLQHVKFWRSEVKRSLGESISNVELVTRADGTMAIIGLATAPGDSARVQMVMQAEIPDVKLDKFGEDNATQRPILELQPFIDPQKVEIVPSDASQRKVPPELALHHERKRGQLVDGVDEFRLHAKSGTLLFVTPTQITVFTNNTTKEIAQWLPSVAVLNVSFCETNPEYVAFTSHGQLFIDRDNSPAFESDASLPNVTNGVAAFVVQEEFERYDAYFWSPTRAEMVYERVDESPVIKLPFTLPSVRSESDGEPMRYPLTGTNNAIVTLRGCRLDEQSGKFVDLALDAKLGSVVPWLEYIVRLGWTADGDDVYALVMDRVQMQMAVLLIPRGLFVAETERGKGIGTIRTIYQESSQTWINANKLLSFVPSLNRQQNNNNCTFIIGSERQDMCHLYLHDSLKDEPKTVTSGSNWAVLKETHLKVDTDRALVFYLSNRTSPVLLSLCVSNYKHPEVGCRVLTPPDMSYRFERACSSLYLNPDIGFVCWLSSVQTLPECRLYRFVHSNGTGDPLPRAVFTHRIGVQVLPPSLGLQTSSWGMPYLYRPPADIVKPILFEYTSTNSGRTHHAMLLLPATRNGLSKFPVIQAVYAGPSIQLVRNSWYSVCHALKFVAFGYAVLMVDGRGSANRGVQFEAAIKQRMGSAEIDDQHEGIRKAAERFGDLLDMDRVAVIGWSYGGYASLLLLACYPSTYRCACVGGAVSDWHLYDTAYTERYMGIPKDNEEAYRQSALSSKVGCLPNQEGRLLIVHGMIDENVHFSHCAKLISALISAQKPYQLLLFPGERHAIRNSEAMEFFHANILSFFARALSSPATLPVQPPPSTAAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9V2</accession>
    <name>A0A914I9V2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9V2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8835.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8835.t2"/>
        <property type="gene ID" value="Gr19_v10_g8835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8835.t2"/>
        </source>
    </evidence>
    <sequence length="1028" mass="116699" checksum="099E265261ECFDEC" modified="2023-02-22" version="1">MSPVPVPPPMQTVTAPTAQSPSSSVITFQPTEQLSLSPTMSPEPVSPPMQTVTAPTAQSPSSSVITIQPMERPLSLSPTMSPPLIATALAPTQQSLPSSSLTASAIHLTKRKKLMLFAASIFNSIFFEELNRQLLIEDITELVILEKQQKQQFSIDEVVKIINHEKVPKLAILRISQKLGVPKSRATLLYTESKRKTASEHQEKATGKRKREPSDGEDDDGGSNKASFPSKQKYQNPKALMPWRPYRKVLPPDVRNSVLSCEDHRNYVAILQNLLTSDPTFRFEHDMKKIKAWDEMLNEERQLYLDTTLRTIKSWKTYPNSLFVYPEAPSLIFVMNHHIMKSRCLIGERAFQGVLLEIPWTNAQQQQSVAFRFNVSVLRPGHGKSLKIPDIRQRFMIKLNHKDIEKKISTKLKQKLSITADIDLRNFAIQNDIEVVMDGSTLCHFLSAPYGHKPQISYACRVSVELEFRGGKMRRVCSVFPPIIASRMHRPFVAREYFKWAIKLQLRDSEQKKDDEKGQKKLKMDESAESLLNELQLGEIGKTAGSSSAGVGKRYAIVTFDGDQQSEFDQHRVLIRTGVHGTENTRVVSLAVRPEFLPEIAAEKISAEETLMDVVTATLKGSQEHLTLRVHFDEQLHQLHLIQIDRKKASDLSRLSQESRKLLSSRIQRFCSLLDALRELNAGEYLLIHDDETVRLVQERNVRQSKKERDSDNESDELNLYIEDEGEENAESDVLSSGPVYDFAWFEHVAKMKPVFSHAPIDDYWNGIDPHYPLQWHIGFSMELFSSSNQNGAWCPGSFLLEMKPCNELASLFVSFPQPNGEGAAEPLGVLRMDDQMLEIVFGDQREVVDAAAEAQQSELSSSVSLQKFASWADTQRRLMMCKVKAEADCVTFVPKTIGQLEDELAQHCLLREYVERIERSRTFQVKCRHCGHLLHSHTKGDFELGVLPYDDWLDTAPQMDYFCEERQIVHGIERSDTGTVARTHCFLCKMQHAIGYHAQKLSECFQTPFVSASRLRGQPAEECLHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA46</accession>
    <name>A0A914IA46_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA46"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8702.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8702.t1"/>
        <property type="gene ID" value="Gr19_v10_g8702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8702.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38628" checksum="FD28FF82AE827AF6" modified="2023-02-22" version="1">MVVTLCMAPLDDRFLVRLPGQNYSVAEPEVMQLVSHSISTFEVPRQRFSYTDKTAMDNEQTPEQVFANFAHLDHCIDGVSQNSVHWKDTLLNAVAQMFGSQTERGLQILDMANKVIAAGELRFLNSTKATDTAFSDAIFLLLTRIDSTYATEAFLRVVQKAMSDQTERREEKIVEENWQGALDSSRKIMKFACRASNKVWDEIINVKVEESAFKKRVFSVIVQQQTESERMRMCIPTSVEVNGWRAANNMQLEFVREMSNAFSAPGMSIQCVAQRWEIQLLREQLAQKDEQLAQKNEQLAQKDETIQERDARINKLLKEAQDAKIAQQTSSSLACGPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAX5</accession>
    <name>A0A914IAX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9139.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9139.t1"/>
        <property type="gene ID" value="Gr19_v10_g9139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9139.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7871" checksum="AF2DFD06721EADA5" modified="2023-02-22" version="1">MALSTTTFALLCLLLNQHRYSKNSFFILFILGLARGESFKTKRFCRVGTALGMFTSKGNNGREFICKKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBL6</accession>
    <name>A0A914IBL6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBL6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9335.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9335.t1"/>
        <property type="gene ID" value="Gr19_v10_g9335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036745508" evidence="1">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9335.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20250" checksum="D8141B30B9A4BD3D" modified="2023-02-22" version="1">MMFKILCLAFCCFIVPTIIALNHKNCICPQNEEPGQQRCNKCEPSCKVPKPKICTRVHCRQCSCDCVHGLNLIGCRPPPIYPSSGNRLTMFKNGILFCIFMDIMLLLCAEADEVCNCPSNEQPGQLRCAGCEPTCNNPKPEICTLMHCTCSCDCMPGMFRDSQTNQCVTQEQCAAPAKERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDK8</accession>
    <name>A0A914IDK8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDK8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8905.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8905.t1"/>
        <property type="gene ID" value="Gr19_v10_g8905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052823">
        <property type="entry name" value="SXP/RAL-2_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593:SF36">
        <property type="entry name" value="DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037527597" evidence="2">
        <location>
            <begin position="19"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SXP/RAL-2 family protein Ani s 5-like cation-binding" evidence="3">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8905.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21769" checksum="F66F3D5C558F9BEA" modified="2023-02-22" version="1">MALFSVLLPFLFASFAFCHLLSPHLPPFLQKASAEDRRRYDKIVTSPNDTKAVINSNLQSWASSAGVVNEYNNFTTSRQQRAQQFQNAVTGNLTDQALQLFTNLWSIRQNDQITRLAECQQIRAALNATGWDRVLERLVPIPPPTIDGPPPPGCFPRPPYSTPFGGRRGPMSAGEGKRRGGPTAQGARLSTTTEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDM8</accession>
    <name>A0A914IDM8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDM8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8919.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8919.t1"/>
        <property type="gene ID" value="Gr19_v10_g8919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8919.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10016" checksum="AAAC7198D0056BA4" modified="2023-02-22" version="1">MSTSGAQISIRNDAQELLMGMLPEGIANNLAYSSSEDGMPNSVRTTQRPVVLMVAPERHKNETETAGEGADEGQQKQQICGELKTKLKLNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEA3</accession>
    <name>A0A914IEA3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Alpha-mannosidase</fullName>
            <ecNumber evidence="16">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A914IEA3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9425.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9425.t1"/>
        <property type="gene ID" value="Gr19_v10_g9425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000002">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000075">
        <property type="entry name" value="Putative zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038168069" description="Alpha-mannosidase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1133"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1161"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1040"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1040"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1076"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9425.t1"/>
        </source>
    </evidence>
    <sequence length="1187" mass="134638" checksum="F03AED88ECEDA1D7" modified="2023-02-22" version="1">MYSRELFLFIFFLNSLNLGELAQNCAWQNCPKWSTKPGAINVHLIAHTHDDLGWLKTADDYYTGTNAAIVPVGVQFILNTVIEELERDPSRRFSFAETGFLHRWLIDHGKAQRNALHRLITETGQLELIGGGWAQPDEACTHYLDIIDQYALGLGLLNATYGTCGHPKVAWQIDPFGHSREHANLAALIGYEALFFARMHYAELQRRADQKALEMIWSSSDDLKTNILTGGFLRGTYGPPDGLCFDALCGNDPIVDNPVFGGYNLESKLERFFNAVFAEVSVRPNGYDEGVKHVMLTMGGDFQYSNANMWFTQLDKLIAAVSSMPSSNNVTVFYSTPGCYVNALNEAQPHLPTKSDDFFPYANANHSYWTGYFTSKPGIKGMIRASSSLLQLARQFSAFALHNGGATIQLDTLEQAQALCTHHDAVTGTSKEFVTQDYVRQLLNGWQEAENVLNASFWYLATKNVSSSLNSNSLHFCSLANESICEATKILSNFSLILFNGNSQKLETLIRVPFYRRDAKVFDNNGNEVKAELLFTAQIAPLGFRTYFVLGTDQKRNIIQQRKANPLSVKNDADQNVPTFIANDFFQLNFGTDGFLQSVADLRRNQTFQLQQQFLYYRGMSNASTKPQQTSGAYIFRPNGTSPISFGTKVQISIIKNSLVQEVRQTVSPWLSQIVRLVPGKPYIEFDFTIGPLPKNKSDLTTTEVITRYTLDGMNSGGIFWTDSNGRQMMKRRRNDPSFFEGTEPVAANYYPVNSRIFIEDDQSRMVILTDRSQGGTSLSDGQIDLMLHRRAFWDDGFGVEEALDEPGEDGRGLIVRARHWLLLDTLSSAEHRPLALEMFRTGTPHMMAFAQFDGKLADYKFRTEFSALSLPISSKIHIMTLRPLDADHVLLRLEHFYQGNENVNSAPVEVDIQKLFTPFTVLSGEELNLAASRPLLNGNEQQLELLDKLEKNVQETINSEFEKKHKVIANEIEGIINASLNDKMEHHFLKLAIIVKSKWLKNRQFHWKLKHAWWQFHSIPFPKYSPVLLVNFKKLQIPQNRSRPENSEANNDVNDNGGQQLLMVDELPEERGVREEEEESTDEEKEELTDEEEEETKHEEEDEESTDEEKEESTDDEEKEVMEKNLRATHADECTECDYRSAQSGNLKKHMRTHTGVKPFKCTICGYRSTHAGNLKRHMRTHTGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFJ8</accession>
    <name>A0A914IFJ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Senescence domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IFJ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g942.t1">
        <property type="protein sequence ID" value="Gr19_v10_g942.t1"/>
        <property type="gene ID" value="Gr19_v10_g942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="14"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g942.t1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43876" checksum="929D5F32B1A05F67" modified="2023-02-22" version="1">MALMLSESGMNTQSAAEWTGKYMAKKGEQYRAGMEPGAEPVNISPAIRHGVFVLHKGGKLIGKVTRFLLDKIGDVGIAVGQRVAGSVNGESVGGRAFRSTATVIGAFSTVWIALEDASKTLKRNMADETVQTVQLRYGDEASLTAHHTLYALGHTTLAGFQLYELGPRSIAGRMARKAGLQMVQKKRLIDLHTNVATALLDNIKTRKLDVLFETEEKLLTGQEIPIVETLRDSPDKEDIMRLILIAACFRSMSSRPNSANFRRSSRSVQSFRMLCILCDSSDPLPIWEASHSSRFVMEGVKNLVPKKHNLPLTKVVEQLTTDVKSGVGVVGITGGSSDFDPDQFRLFDPKLLQGSAPNRDVRPTHAAADVIVFVIGGGNYVEYQNVQEWAKARGLQRCTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GNT0</accession>
    <name>A0A914GNT0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GNT0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10037.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10037.t1"/>
        <property type="gene ID" value="Gr19_v10_g10037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10037.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21652" checksum="1B2FF004E40657DC" modified="2023-02-22" version="1">MSDNVSDEEQQQQMQEISICADVWLEIFAFVSPVKLGHLMALISDRFDVLVDEHFKLRKWPLSWLQIRRATDGNGAQFVKSSDEQLPIPQGPLPSKVIGFKHIEICYVKQIVVEFLQRIRRLFDSAETTVYVWTSNDQSRSWEIIRQKIWPLINDNIWNYIGIAFKDSNIGDGMLDANDEGPTEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPN6</accession>
    <name>A0A914GPN6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPN6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1027.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1027.t1"/>
        <property type="gene ID" value="Gr19_v10_g1027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036995458" evidence="2">
        <location>
            <begin position="23"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1027.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43148" checksum="1D3CF989F6EA9DB1" modified="2023-02-22" version="1">MAYSLAVYALVLYVCWQLLKYAVEVLFPPNLRGRCVVCIGSTTGFGHEFVLRCAQEGMTVFAGCNSPKGVQMLKEKCANLPGIVHPFNIDLASKESIERAFEFVSERLPPGAGIHCVMNNAGIVRMGSDDWLTVEDYEYVFRINLFGLIHLTKKFKEHVKLAKGRIVFCSSICGRFAFPLYGPYNVSKFAMEAYCDTIRRELAPFGVHVAIVEPGYFRTPMTTPENVPSSFERSYRQAPAHIREQYGEEFLQKIKKIAHDHLSSPANSPHVEWVTDVYFHAATAHFPKKRYVVGLDANLVVMPIARLPAEVQDFLLWIVGLLQGQPVPAALHGGKNMLRGAWLYKNGVVNTLNPRDWSRTNGEITEKANQFPSPITHRKIEAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTE8</accession>
    <name>A0A914GTE8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTE8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11045.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11045.t1"/>
        <property type="gene ID" value="Gr19_v10_g11045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11045.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11567" checksum="2F776B160ACF805F" modified="2023-02-22" version="1">MLHNHSQLSQLNGLQSSSVPCLSRSVFGNAQPITGFRSVPSLSANLPLGHRQVQHFHWVHLQLPVQIAAHAKARIVFCSSFSKFSVVQGCLQVLQQQEEDKVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTG3</accession>
    <name>A0A914GTG3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11111.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11111.t1"/>
        <property type="gene ID" value="Gr19_v10_g11111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11111.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15454" checksum="A0DD2C3AB3271F27" modified="2023-02-22" version="1">MVDQIDITTKFTPGKPFIPKMMDNKYLATDDAVIFKERVAPVSVPIVVVVLVLPFMALLAFVSLTLCYFTYYKPRRQQQQKASTKHSEELAVIGKRQTKTDNAMEQQPPFFFDLPSDFDDDDVQSMPLELQSDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU06</accession>
    <name>A0A914GU06_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU06"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10755.t3">
        <property type="protein sequence ID" value="Gr19_v10_g10755.t3"/>
        <property type="gene ID" value="Gr19_v10_g10755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10755.t3"/>
        </source>
    </evidence>
    <sequence length="819" mass="89860" checksum="A5F604187356ED25" modified="2023-02-22" version="1">MSGSSSNTEKKDKFTEFSEHAHHWTLKQDNELKNALQNTVSGMFDSIQHFERVGAALESEMDLFETRFENIRNRIGCLKMERLVKEQVDDISFDLLCGRRHKTMYREQPPNISREEFERRTINTISNAIHRGFELFNAVQDDHPQRNLQSSSGLDPSDPSSSSSLGMPPSKSMDGANLGELPPIIGTPEFYAALRRANEAKTESATAKAVKELSSMSPPTTMTTTKLEEEDIASISSGRSAPPQDPVVVVAELSPTAATISTGGGGNAGHSLRTALMEEIVERAQRKDDSTKTEEEEKKQRIGVTQRVREEKLRTEEEKRKKMPRAEEKQGTEQRRHVDESGEKQKGLRIRNAEQRQRTEGERERIGGETEEHQKSSEGQQKGFQIQKPVGGNPSATANGTPKRMGGRHVKKSLFSSSSEDGDNDEEELFKNSTKSLRPVVGRHIQRQTLANDSSSSPSTNRLWFTAVLFEMEPCSSSTLPVFKPFDVAFSNRLAAAIQNGPVAFRSDRSLSQRPLSAHPISPSGDGQLPPARPVRKTESAVISSNEELGPASVKNRIAQIGAQIPLGQRADGGRREEGHRHGDGGGQISEPTPAITKTIVPLPTEALKTRVKGPSARRAPSQRIVGGRPPAPSSSSVVEPTEAVTEASSARLTPKPALKKGLESPQQRQKNEEEKESPSSRTANLWADDSMKRALERMSKDYVDEEADHQQTSRIKPPPVPATKAQGPKTAAKAVPPPVKPKKTRSSIFSSSSSDDDLGFAKVMGSTPLPGTKEVPKATAVPSNQQQNKQQQPPFSYKKTTTSVKARKGLFDDSESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW42</accession>
    <name>A0A914GW42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM91A1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GW42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11881.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11881.t2"/>
        <property type="gene ID" value="Gr19_v10_g11881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="146"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="436"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11881.t2"/>
        </source>
    </evidence>
    <sequence length="953" mass="106089" checksum="A7A250CA27B089B9" modified="2023-02-22" version="1">MSSDEVESAIRNNITWANLADELRIMLGSSQREYDKRILDYSIRNQLRYQDNIVRFVKRSQEEYYESLLSYSQQRMILYPYHLSDILVRELRITPFTYYTNMIVDVMQAEKSYDSIPNFTAVDVMRMLGIGKNLFLISFGKTFCFIGRNQFIDLMNQNRANRRLFRRSKSVRDILPQKPSNIAPIEPWFQLCYGCIMENDIRLLSSLEKQIIDRLLDEGSGYCGVLDKPIVQRLLSRGLVYLDVPIGSDDYVFVPTLDGFVMNRVQGDYFETLLYKIFVAIDGQTSVLELADTIGIDIGLVKNAVSVFCRLGFARKRVTGIENVLLHSSWANIADCAEGPSGVSCSGLASPAFDQQSTISNSASVNAKLADLSAALMGVRGAGDDDGTITIGEDEAVSDEEDIVAAVEHALKGQQQQQLRVASPVHQQTPGTELSNKRIAFIFDSTLTAFLMMGNLSATLKNHAVTLFEVGKLSDEALDSFIDELQNVNLFVEGEAQRYSEHAKTLLYTLQSLRVSGTEMDLIRGESLHNLDTIARLKVMQRAYKLLVSMAPINAEACCVPLASVPHIGTAAIELSSPWFRLFLYELTGNGPPAMFLPMGIRLGRLPKLFWHCRRLMITQGMHEPLILPIEGALVPTAEALISAPVFVQAYSELISDAEVVNVPFPFLDDKYDNDLDAETADEMVSVIVPVEVELFMGYNRRHSLDYLCGYIVLLKLHHRPHSPPSLVKCSSPSSSSLSSSSVYLAKTASACVEEDDGDSDAKEDTSDANISANLSNNRLLNIPQQPNNNSLNSSRQSMLNYQFNNNSSLSKDPKKICSTRTHLAKGESMDDYVLFDCVFGIPLFDEALNKTICQRIIHKQLCSADNFNYVRFTMQHIIDSTREFVARFQQHNSNGTSPSGFDDFAAAASSEHASTFSISPTCAIAFDPGPNNGRGGAGDDRKCCCWTSKCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWG4</accession>
    <name>A0A914GWG4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWG4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11973.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11973.t1"/>
        <property type="gene ID" value="Gr19_v10_g11973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF341">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11973.t1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35019" checksum="48E6712EABB47A9C" modified="2023-02-22" version="1">MGKIVEQQLETEKAGEWKARVMRILRLVGPQLTVVLLLAIYLLFGALSLRFLDDQLAATVPFTELVLFCFETLATIGYGNICPSTPSGRFFVMIYSLLGIPLCMLTIANLGKHLTKAFWVIVRAFRDKKLSSPLIRRRLPLVVLLAIVSLAIFSISLLCPFTNADEKSKFPMRLDHIYFGLISFTTVGFGDYFPSTESNFLRLLVHLFVLSVGMISMGLWFSFVRDLFMNNFCFHRRHFRHVQDVPVWFGRRRMRLSNLLEVVAKEFQASPTQIHQVLDDLDFLISDALLEVQSNKKSSAMIAATER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXP9</accession>
    <name>A0A914GXP9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXP9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12147.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12147.t1"/>
        <property type="gene ID" value="Gr19_v10_g12147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12147.t1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52966" checksum="961962C43277D401" modified="2023-02-22" version="1">MEILRRWRSSLRSFALDLVRLQHPLSILYLMAINSFFCFVAFYTSREVQLRTLYALSAFVIFIAFALAEHRRNLLVELIRWAFNDFLNSFAVALCAFSVNELHEGRERRAFFGSLLAVCAIVVAPAYAHRRINSEIAKFASRLSNWLRQFLNDYVARPIFVLWDWLKYIVLLRWLSVLVFRLHVSLISAWDWLDLRLFEPLRALRHQLGRFFVYVFHLHWCADLWALIRRMAIDPALVRLSRLLDGFIYVFGCYWLKPALRRMGRACLDLVKFGLCMFGRASYASTALLYEHILCPTIIFCVDRLEQLFVRLFQMAIQPLLTICYQKYKMVEDLALVYIIGPVLKRFLDLVPERNPLEPESDHELDSFIPDFDASDDEGALNEEDTSRSMDREAADSAMDSEGFGDELDDLSSKLSFDGDRLLASGLKRIDISGSDSEVDDFLPISKKSAASGGRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZH5</accession>
    <name>A0A914GZH5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZH5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12540.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12540.t1"/>
        <property type="gene ID" value="Gr19_v10_g12540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12540.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27931" checksum="AD8D3ABFE64D1B9A" modified="2023-02-22" version="1">MQNRQTMMKPKTTATANFSADDDDDVMFVPVQPSTSANDSETDELSEWKGRALFLEQSVKGLEMENKELRHELGRTKNELMRLQKECEQACQERDREINRRRTIKQFEEEERRAHAIASASLADPVPLTADERGRQELMKRIGPPMRRVTVSAVAQSHSAHRTPATVGDAGTSTAAATTTTAVERVQHQQQGRHTFPSALSVFGEYMPTPRRRYYRRIGAAVTSDGTRWAPSSSSVSDISPMKRNAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZJ2</accession>
    <name>A0A914GZJ2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="AlphaFoldDB" id="A0A914GZJ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11843.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11843.t1"/>
        <property type="gene ID" value="Gr19_v10_g11843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="156"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11843.t1"/>
        </source>
    </evidence>
    <sequence length="645" mass="73777" checksum="87D9E2708BC8B365" modified="2023-02-22" version="1">MNVLMVAEKPIVAEEIANILSDGKCSIRTERNGCSVFEYNANFRGKSANFRVTSTFGHMMCLDFPEDYQRTETDPDKNMRDFLASEAEDCDFLVLWLDCDKEGENICFEVIDAVWQAMNGTNGDGRRFMELVFRARFSAITEKEIKNAMSSLARPNIDESLAVDARQELDLRIGCAFTRFQNDYFKNKYFELDKNIISFGPCQTPTLAFCVERHDEIVHFKPQPYWLLQAEVELPGSGGGGICRTLKLEWCRERQLNRGVAQTFFNKVKNCTEATVSDLSSEEHQKEKPDALNTFELLRVYTRGCISYPRTETSAYPDSFDFFAALRELAKMPKFRESVDQILSDGILKPKGGTNKGDHPPITPKRVPSWLNEGCARVHEYIVQHFLATLMRPCKYLTKTVKFDIGGEQFQFQCRVVTDPGFTTVLNWLAVAQDQTMADNAPIVGQRIAIKKVDMIERMTAPPDYLTESELISLMEKYGIGTDGSIPTHINTIYVRKYVTVEQNRQLVPTKLGIALIHGYRRVDPDQTLLSMRMNVERQMELIANGEADYATIKKQTIQDYHDKYIHFVKNIRVVDVPFAEIFTAKVDSDTFKFRNYRSSMKMVETSRPQRLFCPKCKNEKVSKLHGAALSFTGCAFCKQHTPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZP4</accession>
    <name>A0A914GZP4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZP4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12839.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12839.t1"/>
        <property type="gene ID" value="Gr19_v10_g12839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12839.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29384" checksum="9D789BEC4AD70F00" modified="2023-02-22" version="1">MDFYNFVGKSPIVQMAKFKETLDDSSAALAAMSPMIEQQRQWNPYTSQGGTAAALAGDDFVVVASDTRLTGPNEIEILSRNCEKTHILTNKIILNSCGFYGDVLQLKRLLKLRIDHYEFVYQHAMSLEQCSEMLARMLYSRRSFPYYTGAILCGIDSDGHGSIYGYDPIGCMERFPFNASGYGGKIVQTFFENQWTFSTVSPEERKKMPAPTLERALSVMRDAFRGLSERETTTGDSVKLYWAKAGEDQVHHQTFRLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H252</accession>
    <name>A0A914H252_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H252"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12973.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12973.t2"/>
        <property type="gene ID" value="Gr19_v10_g12973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12973.t2"/>
        </source>
    </evidence>
    <sequence length="142" mass="16538" checksum="04B0EFE3422BBD28" modified="2023-02-22" version="1">MLFKIQSAPANLNSHSENPNNSSESLEQLEGIEENQQQQDDYQSCHYVLQWWHYNSNISIGRSRNQQLANKRMPSWIDFIMVVIFERNMGARIEAYVRHEREAVVELCLCNSNKSCCDGPFEAKQKYGGKIDLKRPQCIKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2L3</accession>
    <name>A0A914H2L3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2L3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1309.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1309.t2"/>
        <property type="gene ID" value="Gr19_v10_g1309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037709759" evidence="2">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1309.t2"/>
        </source>
    </evidence>
    <sequence length="255" mass="27939" checksum="66405845DB9ADDA6" modified="2023-02-22" version="1">MRAILFFAVVCLVLAAILETANSKPDAKKAKKGAAASSSKTKTATKAGPPTTSSKKSAPGNKKAAATTTKKDKKATKPKKVQKEKRKSPLKKDKAQPPIKIQAKMAKKPETAKPAVVKKSPSANNRAIRPITRLSNLFTKASEPKQRRVLTLSDPSGDVVAASEPIIVGYSEEIDAEDTSGSDFDMDFDEEHYVNEKADYNDFAANNDELEEEKPFNDYSGMGLEQNMSKSVMRMSHEHSMEEKHFSMSQCPNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2R1</accession>
    <name>A0A914H2R1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2R1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1333.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1333.t1"/>
        <property type="gene ID" value="Gr19_v10_g1333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053337">
        <property type="entry name" value="AT-2_adhesin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37001">
        <property type="entry name" value="PHOSPHORYN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37001:SF5">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037640443" evidence="2">
        <location>
            <begin position="22"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1333.t1"/>
        </source>
    </evidence>
    <sequence length="568" mass="61928" checksum="012B76A6F90C70CC" modified="2023-02-22" version="1">MRRCCSVIFSLFVIINFIVESLEINQKYRHYSNEVELKHPKVPFSTVAENAYKLALAQSRGQQHQKGRHKGRIRQRQQYSPTTTTTKALINARSSLINAPSSLINAPSSLINAPSSLINAPSSLINARSSLINARSSLINAPSSLINAPSSLINAPSSLINAPSSLINARSSLINARSSLINAPSSLINAPSSLINAPSSLINAPSSLINAPSSLINARSSLINAPSSLINAPSSLINAPSSLISAPSLPPSIASVVFDRGGGGQWQFPDHDHHHNPLEGNKKNGDGERVEEHSVVHLISRPTQLYYYGSGGGEGMENAMRNGHGGGGVGAEQQLASASVQVGFSQVCRVKVPTADVFYISYEDDERSGGGMGQRSFVDVFFHCSQYWAWCCGVDCCQLDPALVFTGACVLVVLCTLFVHCCLHSQLGQRVCVRRLFRMHRLRHKRVIARTNAQRRKSTVDGIENARGDVGISRKPSKTVSSGDAEQYRHQQQKQQRRSGGNLRRMLRNSIRETIGRGHRRLVRTGHQFRGDLLKNTRSVPEIVVTEPSSSCFEGEDEEEGRGSSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H316</accession>
    <name>A0A914H316_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H316"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13187.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13187.t1"/>
        <property type="gene ID" value="Gr19_v10_g13187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036918665" evidence="1">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13187.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19223" checksum="15AD453DB9ADFA91" modified="2023-02-22" version="1">MFQILLKVLFVAISVASAAGEETNTFGPDSLGHKCNYSGPGHCPSGFVCKDGGCTRRCLFKGKCPEGFSCKGNFVCLRNECAARDPNCCANCLEKCAKHLDCPSAGWGCVLNKCRRVECHVKADCPFEWPCLVGKCFPPGCKTGKDCPGGWRCGEKRRCVKEEAKGKAKRGKESDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4Q7</accession>
    <name>A0A914H4Q7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4Q7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13635.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13635.t1"/>
        <property type="gene ID" value="Gr19_v10_g13635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF382">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13635.t1"/>
        </source>
    </evidence>
    <sequence length="377" mass="37328" checksum="2B3B12BB3461CA3E" modified="2023-02-22" version="1">MAPPNPSLHRVHPLTPPAVPPHHLRQMSLNPPKVLATMQHAGGGQEQPRRRRSLRLMAFASVAFATVSVLASAITLPIVYSHVQSIQAFMQNEVDFCKTRSRDMWREMLHVQAVTGGMLPSSVDNSTAPLLTATAARVKRQGVGVGTGTASYDAHTLGAGAGSGSPPGTSGNPQGGSCCSCQVGPPGPPGPPGRDGRPGAPGRPGNPGPPGRDGVLLPGPPPKPPCQKCPPGPPGPPGPPGPKGLPGPQGEAGSSGRDGSPGLPGPPGPQGPQGPPGLPGDKGPPGEPGKVINGAPPGPPGPPGAPGPQGPPGPPGRDGQPGRPGPPGPPGDSGEKGADGLPGPHGPPGPRGPPGQPGSCDHCPPPRMGPGYNNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H687</accession>
    <name>A0A914H687_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H687"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14203.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14203.t1"/>
        <property type="gene ID" value="Gr19_v10_g14203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038123954" evidence="2">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14203.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39131" checksum="9BD1921E3D1934FC" modified="2023-02-22" version="1">MAVVFILMLSSATLEAKRNEKDKFFDLMTAIGEHFGGEFNDAEKALKLDLNGANAFLERLHKFATREIGNENDKFYDLMATIGEHFGGEFNDAKKALELDLNGANAFLEALHTFATHKIVEDLVNELSVKFSDEQLFNLLFSLAARLEALVHGKNSDGTLKEKEENPKDKIQTFLAVPKCFILPESELRFTLMIDLCFFYSAKIAVVFFILMLSSATLEAYQRNGKDNFFDLMTAIGEHFGGEFNDAEKALKLDLNGANAFLERLHKFATHKIHHTLSSRLYHRDLIKYHRNLIKYHRNLIKYHRNLITYHRNLIKYHRNLIKYHRNLIKYHREVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H701</accession>
    <name>A0A914H701_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H701"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13805.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13805.t1"/>
        <property type="gene ID" value="Gr19_v10_g13805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13805.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39017" checksum="C3CBE924280F9019" modified="2023-02-22" version="1">MADNWGTGNEFWIPIFRGLILSSVLQTKWCACAAGTAWYNKVWQFLRGAGGVGTSVLAVSKDIIYIVAEKIIDHTFQKGPNILNVVRLATMLLWMLVITYWGRRDGRLELRPLKFVIKKMIASDSILCRCSRQTFHYVKIAYDIPVWISSVTIPSNQCGWMSSRTASVGEQNCNNLLPFVCEKGTLPYREPLLWRRDFLIACICLIALLTIIAAIACCACQRAQRKAQQFPHQKTFLRDNRQNVLTTLHLSHRSALPAFCLKKRLVHLQHQHCQRQFHHQQQNMRVAATVLFPQMHIAFHWHHRAQHVHVQFVVAVILQQIRRLPHIFPPGNTLCLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H736</accession>
    <name>A0A914H736_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H736"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14301.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14301.t1"/>
        <property type="gene ID" value="Gr19_v10_g14301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="94"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14301.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30462" checksum="03F532110B7418AA" modified="2023-02-22" version="1">MLNVTIFSEFTLLNQSRRLQIKDIASHSTNTSEALAQIILWKWEGGAQKIEKNITLNKGKTVEIDCDKASIVIRILKKRQLIENPSPPLNSPDAELTVHIGDRQVTVSANRLMSVSPVIERMLSVEMKEKQQRTLNLDGHDITMEQFMQFLETVNDHLRHGRTLPNPTNVLCLLGLADYFQIDWLKECCEAHLVNCVEIPLIERFLLIDRYRLNNLKNFFLHCLNADKLKEFLRVNHEQQLLSDASIDKKSWYELIIRFCAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H803</accession>
    <name>A0A914H803_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H803"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14571.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14571.t1"/>
        <property type="gene ID" value="Gr19_v10_g14571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF22">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14571.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26578" checksum="32C97166ECC5C29B" modified="2023-02-22" version="1">MLVWRTYSFSSNQLAHRPTWTQKMTFLQVVIISFFNAVCSGIYILMQFIRISEIYIIIGTYTWLFAHGCPPIVYLLLNVRIRKDFANFVRAILRRPSRGHAVAYALNTTAWVNSGTSANEVVQQGLPCGELTSDELVSIFLLYEQPDCVLPESEAVYIRGLPWNILAKNAGFTTQKQLGIYVECNRKNRDPNWSCAGSATLRIKLMDPNNGWYDAKNDTAILEAEVTADKPDGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8K4</accession>
    <name>A0A914H8K4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8K4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14738.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14738.t1"/>
        <property type="gene ID" value="Gr19_v10_g14738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14738.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24404" checksum="3B790A01DD50DD42" modified="2023-02-22" version="1">MPWIRSSRKVPPLEAALDKTLYGQGPTGKRCGCGQFVQLLLTDILSNCYGHLSKIAAYGQFVLFAYGHFVQLLRTFVQIAAYGQFVQLLLTDILSNCYGHLSKIAAYGQFVLFAYGHFVQLLRTFVQIAAYGQFVQLLLTDILSNCYGHLSKIAAYGHSGYCHHFPGTTMADDGPEASFAEAMAKWLHTPRGDGRPKVLYSGLSYGDKRTDGNFEFVSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8W1</accession>
    <name>A0A914H8W1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8W1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14318.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14318.t1"/>
        <property type="gene ID" value="Gr19_v10_g14318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14318.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10108" checksum="1623B1E182BF18C5" modified="2023-02-22" version="1">MRKKEAANGTRVCAAYEAKAFCLLVRQFGDGPYRASAPSILNINCTWSRCGFWFNTAKQLGCDCDGTETRGCGPLGIGRSYQCCPTCLINGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9G2</accession>
    <name>A0A914H9G2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9G2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15438.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15438.t2"/>
        <property type="gene ID" value="Gr19_v10_g15438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037734763" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15438.t2"/>
        </source>
    </evidence>
    <sequence length="149" mass="17192" checksum="FC19FFC685EB67F6" modified="2023-02-22" version="1">MIYQLLTIVLMLIDRSTQQYTTPLTEEDKNAAVQCHNNYRSQLALGNVENKTGGEKMPKASNMYKLTWDENLANLSQEWANKCLLRHSWNGWAGENLAYNGGTFTNKDAFEYACIRWWRELGLYGFNQELTLNDTNLVPLGHWTNVINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA09</accession>
    <name>A0A914HA09_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerophosphocholine acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM120 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HA09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15599.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15599.t1"/>
        <property type="gene ID" value="Gr19_v10_g15599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012926">
        <property type="entry name" value="TMEM120A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 120 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07851">
        <property type="entry name" value="TMEM120A-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15599.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25105" checksum="C6A4903FA4962194" modified="2023-02-22" version="1">MTNNALQELDKEWEEFNTEFTKAETEHLAYLGSYRQLCTVQNGCSDKTKHLKYVLKQLGQDIDSLLRQKGLSEQDKVGLGAKKAQASQIRAKLAEMQRELPAHDNGYYLNEYESFKLSVACVILATFFVVFWLPPFFIALDALCNFLLVWYYCTLTIRESILRHNGSRIKGWWVLHHYITCVLCCITLTWSGGECYETMRPVFFVLVCYVSSVQIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAN7</accession>
    <name>A0A914HAN7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactosyltransferase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAN7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14829.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14829.t1"/>
        <property type="gene ID" value="Gr19_v10_g14829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14829.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22294" checksum="A1963528135D80E8" modified="2023-02-22" version="1">MCCTTENCHNDSIQKPARTLAWPSGQVDPIFAASAGQFRIFVVEQALPVGKPADKFNKAKLMNAGFVEIRILDKWDCIILHDVDWCRNMTTTCYRCFKTHPTHYFRRFDENKYAPLPDNNLAKCPVYPEQYKRVNGYSICFGAGVTRTLTCITVFGYPDERKREMNPPELGYYSSLETGQGCQRHNKYHGKYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBE7</accession>
    <name>A0A914HBE7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g15799.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15799.t2"/>
        <property type="gene ID" value="Gr19_v10_g15799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="154"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="364"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="604"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="726"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="836"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15799.t2"/>
        </source>
    </evidence>
    <sequence length="1281" mass="139832" checksum="272C463C56232D7D" modified="2023-02-22" version="1">MVAPLHFPPFRHIWRSSGQTLPKDIPFRALSTHPLSRNERMAIQAINIVMFRPPPPPNIGLGPSSSLRILPLPSAPSTGHNIKPNHHMLLLLFFLHLPSCSAHQPSTPYAEQSLHVQLVEECPLGSPVLRLPPLPPSFSPWHLSASPHSQLVPFNVSSGTLLVAGRIDRESLPVDANNGKCLLHFVFVSRAIGSSQLASSTSRPTTLAASSSSLNASTKPSPSFRLLRLTVEVLDVNDNAPTFGADPLTLSISESASPGSRFSLGRARDADAGDNGTIGGCELLLLPVGASLTENEDISALFRAERGPAGDFVLELQDGQLDRERAAQLHGQMKVWDIGTPRMEAIVELYIRLLDANDNAPCFERALYTVTFDSNYKMSSDKVSVGKVSATDADEGVNGRVRYELSERTGAIEVDERTGELFINRRRPESVCPPKGNCTFVVNAIDGGMPPLSAKATVVVQFAKSVGTEVASNETGEKKRPGRRDDRPQGGIRIKNLPSGLPFASLNANTPNGTVVSVVTMENVGEEETIDFGFKGSEGLFRLEQIRNGLALLRLNGTVENVGNGRPWTVEIAGKRSDGRQIGPSEKVQIFLRHASDGPAPLPLPALQTVRLPEDLPVGSLIARLNASSSAPSSPYSPTFTFRLASPEWEELIEVHPVAGLLRLRQRLPPLREGEAMRQLTVKVELARDPPAPSAEENAAQAEVLIEVFDVNDHFPLIAGCPPKSLPCVLSVHLLEDQPLWTPFLTVNATDPDSGPNALLSFALRPFGADLNSVSLFAIDVQRGNISLSRSFDFEQWQEHRLWVEVKDGGTPSRKVKALLEVFVEDVNDKVPQFASPEATFLSLRLSQPAHSVLLSVLASDSDPDDRALGLRYSILERGSGTSPLGMFQMADGHLILAKSPAAIGLHANDHFMLQIGAMDCANHSAPSPLNVHVRIVSDLAKVPPKMVAILRPPLEEGNCWTEGDILKALAFPPGDDGPRVANLTLFRGEPSELIIRSKPISLCLRTSSSTTALSSSRSVSHFVLADLGLDGWTLIKIMRRPIPSDDLPRLIFLNAAPNITVTFPEMAIGTPLHRFRLKVIGSSSCQIRFRLEGDRWDGVLGLHPTEGLLWLARHVGWADSKDGTEVRAVAQLADGKAAAEQKFWLRIERKAFDEGAENFFHFPPSLTLFVPDEPPPRPGDLLANLARFSPLPYPCKLRFVLQMSENWWPNSSSNWAATELITLLPDGEIRLLKEPPFGLTIWEREVKAAQQPFGGPPIEERVVRMRLLIRRVSDQRTPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBT8</accession>
    <name>A0A914HBT8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBT8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15160.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15160.t1"/>
        <property type="gene ID" value="Gr19_v10_g15160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="63"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15160.t1"/>
        </source>
    </evidence>
    <sequence length="687" mass="76759" checksum="A1279D717474C847" modified="2023-02-22" version="1">MRGLFSVPCHNRLKVSTHWISARRTAASGATDCTSHDWLSEACQLIHRSRLPTYHFQKSLLRLPVPDLTQSCDRYVDAVGAVFGAHSKEVADTNALVQDFTTGGMKEGRTLQKELKRYAQQNKHTSYISEPWFDMYLGSRVPCPINFNPFMMFAPDPDPSYNDQLIRATNLVISCGRFKKALDAELLKPEVFHMNPLKSDTETFERVCGLSPTAIRWLVAAFAFKAYPLDMSQYQSLFGGCRIPQRGKDRLHHNRNSKHFVVAHQGNFYTVKLFDQDDMLVTPKQIFASISHICNCAKSVGNKSHTNGEGVGSLTTLDRDSWADIRNELLGVDSKNQESLSAIEDGLFLLCLDDLRSTDPERLMYSLLCGDDGSNRWFDKCFQLIVDGNGQATINFEHSWGDGVAVLRLMEETLKDTTNNHFVQVGQGEHSDFSSTDGSVRKLDWHLNDTLRQKIRNAQKSHLEQSQKLGFGVVQHTALSKEAIKKAKLSPDAMMQLAFQLAFHSIYGTFVPTYESCSTAAFLKGRTECVRSSTSATRAAVKAFEALDKNGAGGGDQMRSFLRDCSDKHFKLVKEASMGKGFDRHFFGLRLAAERLGLEPHPLFTHPVYESMNHFVLSTSTLSTDTIYFGGFGPVVPDGIGIGYNVTDTKLGAVAIAYNDNRSAQEFTKALDVSLDKIRRIIGLHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCG8</accession>
    <name>A0A914HCG8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HCG8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15834.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15834.t1"/>
        <property type="gene ID" value="Gr19_v10_g15834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="10">
        <location>
            <begin position="132"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15834.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31020" checksum="EDD6793DBE773C95" modified="2023-02-22" version="1">MSTNNSSSTSISSAGTTGIRVTRQRSSARINWLSELTTRDSTPISTVQQTSKEFSEICKQLILVEDEENIKRIQTKREKEAHERDLAFVKRQLVKSRKDDWLHQPIEELLGYTPNTRFDFLIEALFRSDVIDALKQLNIGRVTIQKGNGVIPAKMQSAKLDIVDGIMFHLFDYLPSIKEHFQNADLIIGHAGAGTCLEALECGKPFIAVINNSLMDNHQAELAEKLAEDGHLLFTTPNELAQSLAKPTLFKLKPFEKADPLIFRQFVENLVLKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCJ9</accession>
    <name>A0A914HCJ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCJ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15366.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15366.t1"/>
        <property type="gene ID" value="Gr19_v10_g15366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15366.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17214" checksum="483CC957F1F180E3" modified="2023-02-22" version="1">MHQLKDNLIAKMEKYQNKQQHSIDELTEMQLRNEQLNALQKKIVKMEEYQKEQEQNIVGLQKTVVTLREIVFSIGLTLQNRLGFRCIVTLSIPRKDDGIFYYEVTIIEESHHVFIGLATKQMPLGAWVRGFNGTYAYGSIGRFWGHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCY6</accession>
    <name>A0A914HCY6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCY6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15468.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15468.t1"/>
        <property type="gene ID" value="Gr19_v10_g15468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15468.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36932" checksum="2D65CE4AA9CE005E" modified="2023-02-22" version="1">MAPSAKKKKANSSVTDCQSLALSRSLITLAAGTRRSARLALKNRTKKIKGTEIVKCIGNKFERRLPIPQKSLPDKVIGFERITISYIDRSAIEFLQRIRRLFDDSKGTNLYIRTNDYQKRSWEIIWHRIWPLIKDNICGISLPFSPQLGCLRKFSPAILSDCAKLRLINLGYDFPNFPADDSAGASSSQAMAKWLHMPRGDGLPKVFRCEFWLRGMEMGGLKLAFVNSVVSVNFIICINHCWSSDGIVPFEVKNNLTRERLELRRFTGDKWLVVRCPIERDEDKWAEWEKAAVRWDWHRQWQRISITFNDNRIDDGLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD06</accession>
    <name>A0A914HD06_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD06"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16373.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16373.t1"/>
        <property type="gene ID" value="Gr19_v10_g16373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16373.t1"/>
        </source>
    </evidence>
    <sequence length="478" mass="54782" checksum="CA1170884100FE61" modified="2023-02-22" version="1">MILQKRQHLTSIFKKNGVDLDLLPLSVKLPMSCFQLILTAEKIEEKHKAKISLFVKPQADAGGYELIVDYKLVVGTWSKLVQKDKWDVEETLLNMEHDSCFIDTLELCANIRETLASQDIKTANSFRSFNVLCSGRSFYLNTAHLNSLGGRMFKEWYERECQGEQNAVIQSIDPDELEELLRTCCAYGPTPVIHRKNFRKVLEIADKEKITGLLRMVESFIIDFECIHPIQKLEFAAEYRMSRLADTVLRSFPVQLDRLDLFLNWSLNSYCLRMYAEFLLRAIFLMGGDCACDIQCCPERVGGVRKLMAVLGSGGHTTEMLKMLAVQDDLFPERTYVIAQSDKLSGSKVEEFEREHGNRFSVKTIPRAREVGQNYLSSVGSTLTAFFHSFLLVNKERADVVISNGPAIGLGICFFARFFDLTRIHRCRVVFIESICRVQKLSLTGCIVYHFRIAHAFLVQWKDLQKKYPKTEYVGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDD5</accession>
    <name>A0A914HDD5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galectin</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDD5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16087.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16087.t1"/>
        <property type="gene ID" value="Gr19_v10_g16087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16087.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25136" checksum="8B2F34A7E097EB5B" modified="2023-02-22" version="1">MFGQQNYKLQEQELTPWKRIPNIQQGTKVIFQVKLHSIEDGFRISFLHNRIQSSKAGDSIGAGIEIINVQPKDSVIVPEYYVVKRKLHSGGQKYQLDKQHKFKAQNAYEFVIVVHSNKYEIILNNNCLNHNATLPFWATNFVAIDGNVTLLANPEVVPPKCKRHTNELSSRRMITIRHEHYSRMTNSSVSPGGLSTDRYYAQIGQRNKIVLMESWPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF96</accession>
    <name>A0A914HF96_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF96"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16607.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16607.t1"/>
        <property type="gene ID" value="Gr19_v10_g16607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019375">
        <property type="entry name" value="Ribosomal_bS1m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13447">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13447:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10246">
        <property type="entry name" value="MRP-S35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16607.t1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44714" checksum="4DD39B7C8D3073C7" modified="2023-02-22" version="1">MASFAKLLRNSSFVRLGDFNGQMLIGRVVHRVNDDLYIDFGLKFNAVCKRPEKDAEKYVIGSQVLIKLIDPELSERFMGSKSDLTLLEADAKLIGLHYNKNQRSGDSSQKNRFGILAGGGAALSLSLFGLGKDDKDKQKEANDEQPLLLIREADLYYEASLIDNAYKVLRRHRSSNNPEVLWRLARVLYKQGRAARSADESKRLCYEAFDFAKKALENQPTTGSFGAHKWYAILLDRTAELEGNKARISKALEVKSHFERALELNAFDATTWHLLGVWHYEFADLPSHMRWLASMVYATPPKSTYDEALRCFERAETISPSFYAANNYYLGLVYEKMNQRDEALEQFKKAYYLPMADLDDRMYHEKAMAHLCRNYKYDEERLIKEKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFD0</accession>
    <name>A0A914HFD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17009.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17009.t2"/>
        <property type="gene ID" value="Gr19_v10_g17009"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6085.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6085.t2"/>
        <property type="gene ID" value="Gr19_v10_g6085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="215"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17009.t2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6085.t2"/>
        </source>
    </evidence>
    <sequence length="567" mass="61221" checksum="13E90CBA76DBA40C" modified="2023-02-22" version="1">MIVATVDGGCRRTTDPTTAPSIGGAANPAAAHRRQKEHNCSINSTPLVTVPHSSLFGWPIQPQHQQHDTFRQNYALNVDRFTAASTNSSSNALQQQQQHFAEFNAPPLHTNAIHQHNSSSSSSSTSSCNDQNSSAYTQQAPPGISNGGVYELVYGDAKSVEASFSNSGTFEHAQYAFLCQSSADTSSTSALVDSLQNRTKISSAVAASIATSYASHTGVNQLGGVFVNGRPLPNYVRNQIVEMNSRGVRPCDISRQLRTGSVKPGVIGGSKPKVATREVTEAIARYKSVNPTMFAWEIRDKLVEEGICDSESAPSVSSINRIVRNKIQQSPYQQQQQPSYVHCSRNSSLVPPNGIVQKFPVTSTTQISISDCAEETYKNFRNQQNGSDRMKRRRDRNEETTTGREEVPIKRQRNDGGNGRVAEGGGQQRQIHVAGSSVPQWTAPSAGVGFGGTGGVTSADHNALSSTTSRCTDSIRGALSVSKRIDDGRSVPSADWLPFRSHLHTTPALAPNHLPPTPSFSPLRSLSIRHSKSLPAIPPGLSFRPLPAFCPFEQNYYSGRPPEAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFP3</accession>
    <name>A0A914HFP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16729.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16729.t1"/>
        <property type="gene ID" value="Gr19_v10_g16729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000198">
        <property type="entry name" value="CUGBP Elav-like family member 6 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16729.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="25426" checksum="3C571BF1CE8D8420" modified="2023-02-22" version="1">MNRAMQVKPADTESRSGSPKQEDRKLFVGMLSKQYGEEDVRAMFQPFGHIEEITVLRAADGVSKGCAFVKFSQAPEAQRAIIALNGSQTMRGASGSLTVKLADTEKERQMRRMQQMAAQIGMLNPLLANQLASATSTALGTAPSPATMAAMATPFGTGTPTATSSLTTAGQFGTDTSKQQTDAQQVPFQPQSANASMSGHPSSAFTQPMHPTRLRCLASGMNPTLVKNRKKNDSEQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFT7</accession>
    <name>A0A914HFT7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFT7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16976.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16976.t1"/>
        <property type="gene ID" value="Gr19_v10_g16976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16976.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="42467" checksum="53FDD9929AA80EF6" modified="2023-02-22" version="1">MSDNPKKVEKRLKENVTKRKFLTISRRFVCDDVLFDVFKFCGPFVLGLNVALISDRFDRLVDAHFKTKEWSLGELEIRRAAGGIGAEIVKRFGNDGRCRLTIPQIPLPDKVIGFQSLRIICIDQTVIDFLQSIRRLFESKETNLFIGSFFDQPRRWEIIWHRIWPLINDNICGLSLLSFDLDHLCQFSPTVLRDCAKLRVITFNHQFPTKCRAVPFSEQAEGKWLHTPRGDGLPKVLKFEFRPIEMEGLKLEFAKSTDPVNFIISIWDRSYVHIVPFHMKNNLTGERLELRRLDESDFWLMVRCPIERDEAKWAKWEQEAAEWAWGGQWQRIIIDFDDNGIGDGLLDAKEGPSEPKKRKNSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGI3</accession>
    <name>A0A914HGI3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGI3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16964.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16964.t1"/>
        <property type="gene ID" value="Gr19_v10_g16964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF382">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16964.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="38150" checksum="3F951C640210A12E" modified="2023-02-22" version="1">MAPPNPSLHRVHPLTPPAVPPHHLRQMSLNPPKVLATMQHAGGGQEQPRRRRSLRLMAFASVAFATVSVLASAITLPIVYSHVQSIQAFMQNEVDFCKTRSRDMWREMLHVQAATGGMLPSSVDNSTAPLLAAAARVKRQAVGVGTGTASYDAHTLGAGAGSGSPPGTSGNPQGGSCCSCQVGPPGPPGPPGRDGRPGAPGRPGNPGPPGRDGVLLPGPPPKPPCQKCPPGPPGPPGPPGPKGLPGPQGEAGSSGRDGSPGLPGPPGPQGPQGPPGLPGDKGPPGEPGKVINGAPPGPPGPPGAPGPQGPPGPPGRDGQPGRPGPPGPPGDSGEKGADGLPGPHGPPGPRGPPGQPGSCDHCPPPRMGPGYNNRRNSITSEKHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGQ5</accession>
    <name>A0A914HGQ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17340.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17340.t1"/>
        <property type="gene ID" value="Gr19_v10_g17340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17340.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11186" checksum="A5BB70692B77CAF3" modified="2023-02-22" version="1">MSMKNEDQQTKRTEIASNAMEVGGLFPFGDFPPSLCPYERLMRAGLEVMALKGCGRSLLPKPKVAFYIDGSVGEGKEECGRGGRKEGEKRRNQGREMEEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HID1</accession>
    <name>A0A914HID1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HID1"/>
    <dbReference type="SMR" id="A0A914HID1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17640.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17640.t1"/>
        <property type="gene ID" value="Gr19_v10_g17640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17640.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16825" checksum="6B40B8917FC7027B" modified="2023-02-22" version="1">MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIQ8</accession>
    <name>A0A914HIQ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIQ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1754.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1754.t1"/>
        <property type="gene ID" value="Gr19_v10_g1754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1754.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18942" checksum="F7C99F823BDD681F" modified="2023-02-22" version="1">MDHVIATIEILSEHTGEEIASTFYEMKNALLKTDDYLREISDLQRRPTNFSQNEWNNLKRLAENLVPLSREDFVIIGELCKVLKVFHVETCRKKTVPVQQQSPDQVLQNLMIWSLLSLNSIFSGMELFDLKKTMLAPSVEPDDDELDDKEEIEENVFVQQQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ27</accession>
    <name>A0A914HJ27_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HJ27"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17842.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17842.t1"/>
        <property type="gene ID" value="Gr19_v10_g17842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="234"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="430"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17842.t1"/>
        </source>
    </evidence>
    <sequence length="580" mass="65848" checksum="51F9AFAB062CB6A4" modified="2023-02-22" version="1">MVPKGMVKSLLYQILNGIYYLHNNSIMHRDLKPANILVMGEGTGIERGRVKIADMGFARVFHNPLKPLSELDPVVVTFWYRAPELLLCSKHYTTAIDIWAIGCIFAELLTTEPIFVCREEDNKQTPYHREQLERIFFVMGYPKREEWPDMLRMPGYDKLKDDFTKDLHRFKDASLRRHMDKHRPGDQAFSLLERLLTMDPLKRITAAEAKEHKYFKDSPAPTSDVFSGCDIPYPKREFLKDEPDDKNNGSKQQAPTLPVAVPPTVPAHTHNPPTIEPPATKKLRQAPHPSMNSSGGGGGGVMKVAPPQQMGGGGSGGFQQQSQQQQQQQHQLMEQQQQQMYGSSHSGLGPPATDYRLGTAAPPPPQMQQQTQQQFSVGTGMGPQQGTMAATTAQQQQQLGGFQQLQMYQQQQQQQIQQQQVSSTQQQQQLQIGGHQQMGSAAAQQQQMMQPNQPSQQQLRMAQHQQQQGGVQSHGGAMMPPQFMHQSQQPQQTLHQQQGMVQQQPNMSSAQPQQMQMRQQPQMGGFVQHQSQQQHVQQMHQQQQQQMGIMNPQQQQQFMMAQQQMAMNHQQNPQQQHRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ79</accession>
    <name>A0A914HJ79_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HJ79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17672.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17672.t1"/>
        <property type="gene ID" value="Gr19_v10_g17672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="576"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17672.t1"/>
        </source>
    </evidence>
    <sequence length="628" mass="71841" checksum="3E10A3C5F6B64161" modified="2023-02-22" version="1">MPQNAKLNIEAVMNCLQKLFITMQFTPFASTHAGELIELLRLNNQQQDVQEFHTLFFDTIERNIESHPNSLPVFNIIWKLFESRINQTLYCEYCKWTCTTTDEHRSLQLGINRHDNLGAAIKAFFEAEILSDFQCPHQKCQYKGHVSRTREFVQLPEVLIIQLNRFVVGRNLRVRKLQHAMHFPRILTGEQLQPGVAGTRDYTLCAVMIHRGKRMDAGHYYDIIHEPTIGKWFTYNDGIVTETTAPGYSGRLTNKSMTAEVGGCYALVYRKLGTGVQRGPMQAPAPNVLTEVENKLEEDFARKKNDDGTAFEIWKRLIGERSVRLRQLWTELEVHNGMSFLDRPDGITFLPTALLRDILAKEHKAFDGCKSVDSTYAPSPVSAVAIPVCAHNQLRPGPFTRGTLKAVNTLAARRLIREYNVNLTQRNGADFCLVCLWKIRDYFVAEFAGPRLPDFVEDFFYPGGAFIYIKVQKSLDPEVINRNALMWISRRKKSKNLIKIKMCSDETIDDLKARIYETIRHPPANQTLYRARSTNLRRQTVRQVDVELEGNWTLEEALIPPDNLEQPLILILSVEDGDEDNDEQSTSDGKEDNDEQSTSDGKEDNDEQSACNNSPEEDEDAQRMDTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKI0</accession>
    <name>A0A914HKI0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKI0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g197.t1">
        <property type="protein sequence ID" value="Gr19_v10_g197.t1"/>
        <property type="gene ID" value="Gr19_v10_g197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g197.t1"/>
        </source>
    </evidence>
    <sequence length="661" mass="72106" checksum="BA4FC2091BA4FAE1" modified="2023-02-22" version="1">MKLTADFERGQHAALLRRGRPNIVLAKACFCEAIAERILEGESPANLHKWAFHEQPPKFLKSFLRSFAHSAVAASGNARAAIVHAPPPLGPFSQSATQIWPVASGDRPGGAAAGQQYGHHSFDSLERSAAEMAENGCAHSVLFGTILGSDRTGYLTLLQNWGILLSAVRDSRGQCLMHWAVQRQSTECMLELFALQRGGGAAREWVLARDNRGITPVHLAAAQDSARVLNMLLAELGLADLPSAATDQDGMNPLHHAAAAGSASCCEQLLSEQWELPVDVRDAHGRTPLHHAAWSKFAANVFRLLANKKHIAVSARDERGWTPLHTAVVANNEAVLRVLLHELRVDPQIFDNESRTPLHYAALHDRTELARLLIEYGASNDTRDRSNVTPAHYAAQWATYETLRTILNSTTTQTAQIEGVQRGRNNKCDAVVFGLSGDRRNQQLNEWAAPQPLDNEGRTPFMWAVIAQNQSVVQQMLVDKNIGAAGRLITGRDVFKRTPLHLAALVGNLELCKLLVNEGHLNVNDGDMHGATPEHLAAGQGNSEVVLWFGYIRGGHVKPPMDLIDRTPFLYACLGGQANTVEAMLRSLHVDPSHVDSLGCSALHCAVISGSLHCVRALVESKSGSFDLFLEDKECRTGLDIAKEQQLAQIAHYLEAKMAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL93</accession>
    <name>A0A914HL93_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL93"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17662.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17662.t2"/>
        <property type="gene ID" value="Gr19_v10_g17662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF43">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17662.t2"/>
        </source>
    </evidence>
    <sequence length="470" mass="53015" checksum="75544AF7F6F5C49C" modified="2023-02-22" version="1">MFTSSYCPLKMLYEREISGEPSPVVNMFEQSKKSLLYQRDLKSHTGCVNAVDFSPTEEWIVSGGDDLKVRVWRTGDCCTSEKPGLNSVVMKSIHHSNIFCLRFSHHTERIYSAGNDHRLLVHDIKTRELLRSYRARSTIYHTATHPSDDNVIAAASGDKNVYLFDLRGNEGDGLCTKLRQEGAAYCAVWNPQNHNFVAVCNKKEGLLVYDLRMSNNTYAEAGKMTKRAMCADWSPSGELLLCVISQANPICFNLQNSEHLQLSDPKYSNICTVKSCAFAGEQYMISGSDDWNIYVWKVPTNWSDCADGCARAHTVLEGHRSIVNHVKYGQRNNLLLSCGVEKIVKCWSGLPLRDSYQKPKRRERISLPSAYGELEHGAMDSDTEEDLDTLQRFDFFYEQTLRSAARTVIDSTDDELSDGSSDEDIARMLFPQTQYDEDANDHESFFSEITSGLHSPSPLHSPDSSQSDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLD3</accession>
    <name>A0A914HLD3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLD3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1852.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1852.t1"/>
        <property type="gene ID" value="Gr19_v10_g1852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1852.t1"/>
        </source>
    </evidence>
    <sequence length="540" mass="62691" checksum="9885975D1D7BDE1C" modified="2023-02-22" version="1">MHSQRINAEQSRTGATPARRCRHGQQLDMDKSGNNNPTELGPSSAFNSSNIQLEPPNTMVCARKLLDGCVRDRCCQVALDADVYFRTTHKYFKAFTKCKEEKEHSDAKLLQNKQLLVGLGEKLKLLQAMFGHDEQKKEALLAENVLLVADKVELQGQLHEQQALSVRLQVEIDRLRTSTEQKEVNSNEEHGDQEKEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEKEESTDEEKEESTDEEEKEEELMEKNLRTQGKKFKCTICDHRFSLAENLKRHMRTHTGEKPYKCTICDHCFSQSSGLQQHMLFMHPSGGRKFKCIKCGHRFARAAELRRHMRTHTGEKPFKCTICAYRSAHSGNVKQHMRTHSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNL6</accession>
    <name>A0A914HNL6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HNL6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2256.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2256.t1"/>
        <property type="gene ID" value="Gr19_v10_g2256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="101"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="656"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="851"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2256.t1"/>
        </source>
    </evidence>
    <sequence length="875" mass="98835" checksum="F90D11CF36ED4BBF" modified="2023-02-22" version="1">MGLDWIVPFEQATQLAIATTLPFPQAPAVHAILQPTDDPTELAEQMKNSFPSVFQSGLGHCTKTKATLHLKSQAKPVFCRARPVPHGVLDVVDKELDRLLEIGAIKPVDFSRWAAPVLAVRKKSGAVRICIDFSTGLNEALELNRHPLPRTDDIFHALRGSKIFSQLDLRDAYLQMELDESSKSLVGINTHRGLFAYQRLPFGVKSAPSIFQKVMDQMIAGLPGVFAYLDDVIIASNTLTEHVTTLHQLFVKIQEYGFRIQMEKCHFLKKELRFLGHIVSNQGVRPDPARSAAIRDMPPPTDLSTLRSFLGALNYYGRFIKAMRELRGPLDVLLKKDTPWEWGEAQQAAFDKAKEVLQSDLLLTQYDPTKPIIVAADASQSGIGATISHKFPDGTERVIEHACRALSPAERNYAQIEREALALIFACQKFHRMIYGRKFTLLTDHKPLLAIFGNKKGIPIYTASRLQRWALILTNYDFTIQYVRSENFGQADVLSRLIAAQKTDEEAVIAYTSADQMDAADDVVEFVHLANMEPLPVDATEVSDHTAADELLQQVVTYVRSGWPQKGLGAELMPYFSRRNTLTCVGGSLLTGTRVVIPRPLRQRVLKTLHFAHPGITRMKALARRHVFWPGLDQEIEDVVRSCTECQLAAKLPTKAPLRPWPTPDGIFGRVHIDFAGPCWDGNTYLILVDALSKWPEIMQMNSTTAFSTTEALNNVFHRYGFPSELVSDNGRKALSILSRHPISRTATVKPNPSRTVNTDANRQQYRQHMKQQYDRRHGATERQFQIGDSVLALSYGNRNRPRWLEGQEWFQMLTDQTTDIRQGLQRLFSKGPRVRGRMYTPLHRHHVRQYRSTPRDHNVNGDHLFGSRPVDNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPK3</accession>
    <name>A0A914HPK3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPK3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2524.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2524.t1"/>
        <property type="gene ID" value="Gr19_v10_g2524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2524.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="24985" checksum="F8D190CDEC11977F" modified="2023-02-22" version="1">MPTHYSERLCVGLQRGASTSTRGGVLKGGPGPWGPQKASPQTPISPPTRIHLYCSGQQKMRKLPLICRGRDGFSLPKYEIVDCSPPDDHCFSGFCHTDREKPNEYYYIFGCAEYQYNNNECRNEIGKFEDEAIQNGQMEVHLLGSGKRQTYGKSRVISAGCHYGVSVAATAAVSGRAGAPLAAVQKALFAALLIIGILTHFFHGTIFTDHQSFNHIMEFESVVANQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPT8</accession>
    <name>A0A914HPT8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPT8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g278.t1">
        <property type="protein sequence ID" value="Gr19_v10_g278.t1"/>
        <property type="gene ID" value="Gr19_v10_g278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g278.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10032" checksum="AFBFBDE259D8A08E" modified="2023-02-22" version="1">METQRRKGCGGMEREDAQTILRLLHRSVEVARDVNGSSGVAKKWPNFSLFHLLNAFYNFAARCSRFVSEYVKMWTLVKGFATQFRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQB6</accession>
    <name>A0A914HQB6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQB6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3470.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3470.t1"/>
        <property type="gene ID" value="Gr19_v10_g3470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3470.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10777" checksum="404773D34E70ADA7" modified="2023-02-22" version="1">MYNSSRCGHGNFGLSEPVNPKKKNWAAQPKNVQQLTYAKHPNLKSSQQVLSDWGKKKRISLCATAVVTHNPLPGTQSSTVLKNPYFSQMHDKKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQN5</accession>
    <name>A0A914HQN5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQN5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3757.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3757.t1"/>
        <property type="gene ID" value="Gr19_v10_g3757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3757.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35850" checksum="B1ACADE5DBDED816" modified="2023-02-22" version="1">MDVPTKLRSGPPGKRNQGLLQGQFSRALRPSLPREWDKIFAQELRAISEIFPHVSASVAAPKGAASKAVDGLPDRTSGGSLTFSCPHGIFANHRFTVRCETTTSGPFDFMEQNAAALGQSRHRQLAAVVKAHNANNKRRHHPDHHTHCQFLQSWRPRCCVFVLLLGRIYTECHGLQLKGRIYTHCHRLLLPKIRRHVAATATAAKRKGEKKEELIDEWRRFFRLLSTLLGGRAIKMGKSVRRRIGVKCSARHFSKFVFHSFLRRILLRIRSGVLTRDEIIGIYVHHSHPYVGLPKLYPLQFPTNGRAFTAEKSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR60</accession>
    <name>A0A914HR60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3879.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3879.t1"/>
        <property type="gene ID" value="Gr19_v10_g3879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037242201" evidence="2">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3879.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19918" checksum="EEC7367C6B37E757" modified="2023-02-22" version="1">MEEFWILILVAFIVTNSLDKAESVQLEELEELPLQTFDELFVDEWWDKSEAEDLKMPAPTNFGQNVHQQIVRQNTQIGQIEPNSNDQLGQTEPNSTDQLGQTEPNSTDQLGQTEPNSTDQLEQTEPNSTDQLGQTEPNSTDQNPPLTETAYLFCSCSVLTSRTEQEQEQNRNRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRJ2</accession>
    <name>A0A914HRJ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRJ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3576.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3576.t1"/>
        <property type="gene ID" value="Gr19_v10_g3576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3576.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8174" checksum="BCBF3531CCBA38C2" modified="2023-02-22" version="1">MEIFFPHLLWTSILDSCLVALIIWLCNFKRGKSAKIVTIAFALAFMNSMVVSKPKFLQLLILIFGFSRWPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSB5</accession>
    <name>A0A914HSB5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4013.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4013.t1"/>
        <property type="gene ID" value="Gr19_v10_g4013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4013.t1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6368" checksum="889FB1AD56F5ABEC" modified="2023-02-22" version="1">IDEYGTAASPSEPKSIGSFFGLPQLSFARTFQPDGPFAFFVTLHKKHVIFSGVFMGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSD2</accession>
    <name>A0A914HSD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3312.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3312.t1"/>
        <property type="gene ID" value="Gr19_v10_g3312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3312.t1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36585" checksum="66FC8560B72E01C0" modified="2023-02-22" version="1">MKYSEKAGGTKAKPPNLKMPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQLGQIDPKTEQNPPLTESDHSGQIEPNSSDQNPPLTESDHSGQIEPNSTDQNAHLTESDHSDYAEDEQKRNIIDKFQAMKDEFKQKGKFSAKEWNQIEEKIAKHLKVNRSKIYEWKKEFGLSRKAFYAEEERKHLVEKFNEMKAELTQAGLKNSYSNQIDEIVAKELGISFVTIYKWKSELGQIEPKHKHPHSKQMELMKRYYEIKDQIPKIIDKDIAKILKIGSATLVRWKRQFKRQQFHPNSVDGHSVEENAAANVQEIENITSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSG2</accession>
    <name>A0A914HSG2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSG2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3537.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3537.t1"/>
        <property type="gene ID" value="Gr19_v10_g3537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3537.t1"/>
        </source>
    </evidence>
    <sequence length="510" mass="55917" checksum="059130955E3DA541" modified="2023-02-22" version="1">MGSKGASDNLAETTDSALRTTVDKVHTVGEEDALEGVAIIPQNASPTAVPSASSSSSNAATAAAAVSSSSSGDSAGGPPQDRYAKLRLQQELYEDIAVPTQPYNGPEAVSSFMTTVLHMLSWGHATSIEATVLSKNLEKPLRFSGAAKVTLVEYDTTNYCKICLEGGMFTELERLLSIVTRNGFYFALPNHGHGFRQLNFEEMHFESGGTAAAEFSFNLRERIMTEELDICNVAIELLMAANKSYKTADLPWKLPNTVVEMLSGQMQPLVWPSENARKSTAADQKYIAQRNSFGPPGTGKTNIIAHIVILGTAAYDITCQDDSLNARMERLYTARAAPLFLVVTATNSAADHVALAIKKLAKDMAKAPHQNYQGKRLRLGNVVLMRKYSKLVPTSAVPQELFSCSNKDQGRKFDPQKISCIVMTMGHAKAFKYLSRVCPILRKLQWPNLFEFFGVCCRFDMNTTRSELLNKCREVRHQRQVHSMSVFKPSTACVAKDLQEDASDDDCWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSU9</accession>
    <name>A0A914HSU9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSU9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3651.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3651.t1"/>
        <property type="gene ID" value="Gr19_v10_g3651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3651.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8364" checksum="67588EF7E86C0C71" modified="2023-02-22" version="1">MDRHFPPIPLVLAKTGQLLNVRGLNHIADAFKKAVEENMICRCCRKKIEFIAELCICPDSNRKCHHATGCCNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT47</accession>
    <name>A0A914HT47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g352.t2">
        <property type="protein sequence ID" value="Gr19_v10_g352.t2"/>
        <property type="gene ID" value="Gr19_v10_g352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22432">
        <property type="entry name" value="KH-I_HNRNPK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22433">
        <property type="entry name" value="KH-I_HNRNPK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22434">
        <property type="entry name" value="KH-I_HNRNPK_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g352.t2"/>
        </source>
    </evidence>
    <sequence length="718" mass="80518" checksum="D161C93565887ADD" modified="2023-02-22" version="1">MVQEFNNTVNIPPPLPFPPNSPNPSMSSKSNCEDEEKWRHLMGNHHELCDLEKCLGKRINGLFICQFSNIPGHLYSQYLRHRRRQGAYKTKPCRNFYGPNRFCPTGDLCSFFHEMDEKRELLHQPTTTNFVMNNDRDNTDPSMHPFAFESIKEEHASVMFGNNNEQQQQTLNNLILLVTETYQRMCKQVISSDDYLLSMKNAHQMQQKSKHWPFNLPLVTADRMVFERNCAAAYQTKKKDPCWEDCSTTTESSRSLSPTAPPVIRKLVTYTLPLDSVDGAESPRISNRFQSHQSGAEFAKSFHPFGESYPFKNLTKGNPSGTESSGTVEILTEIDAQFHGRITSRGKYQNGVFNRALLLFIIFLVYIILLHQAILDSIHFFVPDDMKRQLEPMEHHQGRMSSGTKRYRTDGYNDALAEGKFELRLLIPTKSAGAVIGKGGESIKSLRAKYDAIVTVPDRSTPERILTIVCAQEKLADCFSEILEKLAEDQGRDDVDIRVIVHQSHAGAIIGKQGSKIKELRELMQAQIKVFQECAPQSTDRVVLITTQQTKMPDAIKHLMEFMREVPIKGPTKPYDPSSHDPRIVQCYGGFSGPMPPPPMGGPPMGGMHGGGGFGPRGPPGVPAGMGMPGGFMQEQVTTTQVTIPNELGGTIIGKGGDRINRIRAESGARIEIGNAYGNEERIITITGTPHQIQSAQYLLQQSVRTSEAGRRYLREQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTZ8</accession>
    <name>A0A914HTZ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4657.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4657.t2"/>
        <property type="gene ID" value="Gr19_v10_g4657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4657.t2"/>
        </source>
    </evidence>
    <sequence length="224" mass="25609" checksum="85FBACD152C8EF6B" modified="2023-02-22" version="1">MSAKIDKNRPGQLRDPHVIEHGLPEDRGNYVIQHVIEHGLPEDRGNYVIQHVIEHGLPEDRGNYVIQHVIEHGLPEDRGNYHGLPEDRGNYVIQHVIEHGLPEDRGNYVIQHVIEHGLPENRGNYVIQHVIEHGLPEDRGNYVIQHVIEHGLPENRGYYVIQHVIEHGLPEDRERMVRQVDKTGTILWSTGGRAHILTIDEPGIRNTAGGDTMPELARRTWGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUF5</accession>
    <name>A0A914HUF5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4581.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4581.t1"/>
        <property type="gene ID" value="Gr19_v10_g4581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="438"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4581.t1"/>
        </source>
    </evidence>
    <sequence length="638" mass="74345" checksum="86D749F9A2BC8D4A" modified="2023-02-22" version="1">MLISTKSTSGGDITADSEHLWPTLTNLDPSEQLRLLRARIAQLKRQQKVNSPTSSSAGFKLLAQNAKRRRIEGHEADMKQYKEELKDMKQYKEELKDVKQYKEELKDMKQYKEELKDMKQYKEELKDMKHYKEELKDMKQFKEELKDMKQYKEELKDMKQYKEEMKNMKQYKEKLKTRKNCIFLAICVQKALRAELEHQKLVNAHNALHTKMEEYQNKQQQTIDALTEKLKASRTREIVKRSQEFNGRNEGTTENGRFEAATAPKETNDKIAWLNEDQQKLCGADHFSQTISVLEHKRKNDQKELLLKMDESLKSVQAMVIAELGRLNMKELQNDQKALLDRLKGLEQKQKQCNERKEQKMEEYQKEQQLNNFLGLFVEEQNKKFEEQNETNGMLQQQMDELGNSSKKELEKEMNRLKSELSAKMEQYQKQQQQNVVDLQKTVALLNYTINGKGPIPQQNRWDSAACHDQLALIEPERLIVQYNGNDNWGWRSVFTERPIPKNPFVIFYYEVKILGKGTGISIGLATKQMPLDTTVGHSNGTYAYGSGGNFWGHAVGGCSRLVGRRDIKGKPKFEEGDVIGYGVNLATRQIFYTKNGQRLETANLFVDSADEWFPCVSLFHSGDKIEANFGPNFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV17</accession>
    <name>A0A914HV17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HV17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4047.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4047.t1"/>
        <property type="gene ID" value="Gr19_v10_g4047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="115"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="195"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4047.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30487" checksum="ED092FCE7B7B28FD" modified="2023-02-22" version="1">MNYGATIETDESKLLLPLDPCDVQLKQGHHRPPVTLFNETFGHFVGPEQLLPLVASPNSSDRTASANAEVNAEYASDGAHFLGPTNLPNPFDQRIHSGPCGDPQPGFIFTNNLLRVCRGCEMEIHDRHLLCVHRPRHFTIRRGASEGEDEYWHEHCLRCCQCEQQLRTGDSCFVRDGRIYCREDHLKSFGPSCQANCSRCAHPIEPAEFVFRSGPSNVFHTHCFKCSCCGNPLTRGDQYTDVAGELICERDLNLMQLQHQLRDITIGYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVI1</accession>
    <name>A0A914HVI1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVI1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4877.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4877.t1"/>
        <property type="gene ID" value="Gr19_v10_g4877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4877.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17754" checksum="DEB6DFCE8A5B7637" modified="2023-02-22" version="1">MLLYALIRRFEEEGEEDVEEEGAEEIQVLVLSASGLLPFRWRYSPGRPMVDEHLAQLLLQLGLPDPDIHTLSTKTALAEGERDGCVVHVCTERTESPGKDMDNAWAEVQLLAVELSAFPSLHQQLPDMGEYSWRSHRRLAPEQRRFVERALPMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVK1</accession>
    <name>A0A914HVK1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5076.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5076.t1"/>
        <property type="gene ID" value="Gr19_v10_g5076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001152">
        <property type="entry name" value="Cleavage and Polyadenylation Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.50:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000089">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.50">
        <property type="entry name" value="Cleavage stimulation factor subunit 1, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032028">
        <property type="entry name" value="CSTF1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038184">
        <property type="entry name" value="CSTF1_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16699">
        <property type="entry name" value="CSTF1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Cleavage stimulation factor subunit 1 dimerisation" evidence="6">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5076.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="47955" checksum="C08B169FDFB54DF3" modified="2023-02-22" version="1">MKSDLKDRDFMYKLIVGQLFYDGHQQLALNLAQTLGLSLRPPPPSDKLFRLVTIAKQFVEEPESKEREMIMQVGGFEAAGLDLEFDADVVPSSPEPSLYETVYLTTHKAACRAAAFSSDGALVATASHDCSIKILDVDKIISRIDTTLSESGPDAHHPVIRTLYDHLDEVTCVAFHPRESILLSGSNDFTLKMFDYSKTAVKRAMKTITEVEPITAVSFHPSGEFFLCATRHPTLRLYSAETQQCFVSAVPKDQHTDCVTDVSYSENARMFVTGSRDGNVKVWDGVSNRCIETFTRAHDGAPICSAQFTRNGKYVLTVGMDSVPKLWELSTNRCLIAYTGAGTTGAREHPMQAHFNHTEDYVMLPDEKSGSLCSWDARNSDRERLLALGHTAPTRAFVHSPSMPMFVTGSDDHRIRFWYRRRQWGEGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW15</accession>
    <name>A0A914HW15_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HW15"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4291.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4291.t1"/>
        <property type="gene ID" value="Gr19_v10_g4291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4291.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="35496" checksum="D08ED368FBAC79E6" modified="2023-02-22" version="1">MTSAEESNEQLVQEIIGNVLSDTVKDEQQQEELQLLEDEGKLNGAGTVDVVDVGHLSFVQPADESNDCSMENVKEEQDTEEIVQCIADKIEGISLNENIKKEDANTPPTEQDDKVSVNSNENKEELQLLEDEGKLNGAGTVDVVDVGHHSFVDESNDCSMGNVKAEQDIDEIIPCIDDKMDEIVPRIDDKVEGISLNENIKEEDDANTPPTEQDDKVSVNSNENKDALSSPPREVPSVVAVVVTPLPANAQQQEDHQQHLEQIDSAAQNAETNRESAGDDTDALSSPPREVPSSTSAKDGGVVGKGRPGCSAGAAAAKTEAKAKTKACSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY24</accession>
    <name>A0A914HY24_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HY24"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5090.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5090.t1"/>
        <property type="gene ID" value="Gr19_v10_g5090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5090.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16378" checksum="6354E8F0E876770C" modified="2023-02-22" version="1">MFVHPMIGFYCKLWTLQQKLEIAIQEAEEEEMKGDECIASQSYLWTNLPEIKLDAEFRRAFLEMTGPNCCQIGTDPDEPAMILHIKSIGRVNSVENVIHCKNISDFVESRLGIPPVRVMIHFQSLEKHEVGKGGTTVEMLLADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ26</accession>
    <name>A0A914HZ26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5351.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5351.t2"/>
        <property type="gene ID" value="Gr19_v10_g5351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5351.t2"/>
        </source>
    </evidence>
    <sequence length="82" mass="9177" checksum="5320458FB65CD5C0" modified="2023-02-22" version="1">MTDPLRPFYFSDFAHSLWRRSSGTLKRMAKEAFNCALYDSSVDESVSEQLSARQLDLDENAAQTTTAEHLGLLFSLITTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZB6</accession>
    <name>A0A914HZB6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZB6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5414.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5414.t1"/>
        <property type="gene ID" value="Gr19_v10_g5414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="243"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5414.t1"/>
        </source>
    </evidence>
    <sequence length="606" mass="68953" checksum="61286C9044296FCA" modified="2023-02-22" version="1">MNIEKLVRCKIEGLQKMNKHYIAVEQSSVREEETNQSMLHRDSSITSVGDENLEPVEFELGKTIRGKECAWYNGFRYLRNAAHSLSWRCSDRKCKGTLRILERRDDKAFGHVGQHEHNHLPDPARKEADSKKLSLKRKIQEEPSAKPSKIFGQVRKDVNCEVFVEMGTDIALRHMMRREKASVFGNVNSANPLTINLSDALIIKDGESMLLYDSRISRPNQGDVVLVFAIPKCTPAQWKQCLVIGASVRKRMVVCVHALLPGKHRKYYEEVLQVIKQAVSPSFPYAVLLDFEQSEIKAVNNVFKNTSASGCMFHYGQSLVRKWKDLGLEELYGRVDAARSTLRGILSLPLIPPEHVRRAFYLLVDQSPDGLQSFMAYFCRVYVGMTRLELNGGANAFGPAANQRGEASILFNNSGRSLVSNSTRHCDNLNVFDHSYSIQFGFPSPRPSTPSMPSFATTMEVLRWEIEVVRQPLYPIRFWNVHQQAASALARTNNALESSHLHFSRNLTNHPALSDFLRAVSDDADKQHDIYRSARLHRNIQLRHKKFVLQERAIMTTLQDAEYETDIDLLQIITLLGLQIKGYLVGLHARRRESEFGEGSTIEQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZX4</accession>
    <name>A0A914HZX4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Matrix-remodeling-associated protein 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZX4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5327.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5327.t2"/>
        <property type="gene ID" value="Gr19_v10_g5327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026622">
        <property type="entry name" value="Mxra7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057534">
        <property type="entry name" value="MXRA7_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21845:SF2">
        <property type="entry name" value="MATRIX-REMODELING-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21845">
        <property type="entry name" value="TRANSMEMBRANE ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25473">
        <property type="entry name" value="MXRA7_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Matrix-remodeling-associated protein 7 helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5327.t2"/>
        </source>
    </evidence>
    <sequence length="241" mass="28286" checksum="41C9DDAB343FBD36" modified="2023-02-22" version="1">MFPSDDFVPSDPRPSTVWEALRHALTNRRLIAMYGLTFVLAVAIPLIVTFAVRKWRERNIRPKLKERAEADEHLSNQTTGTFNKAILNSLHHFEMRHEKSDKTNFSIDKLCWTPSANVENEQQKNEEEKEEEKEEEKEEEKEEEKKTLLEKEEGKKKRKKYKDPDPETAEGLKKLTEKGLHGKLATAQLRAKTQLLEEQMSDEDREKDQLEAIFKLMEAQKEKFGINDKEELVEQLKMYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I045</accession>
    <name>A0A914I045_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I045"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6088.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6088.t1"/>
        <property type="gene ID" value="Gr19_v10_g6088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6088.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38597" checksum="C20A5F4371492EA1" modified="2023-02-22" version="1">MRTTKKRVRDQGQHQTNKQHLQGEIFELQKLDRQIIFALMLDIDSLARKFLAEQYDHSLNRFAEIFMEMELSSIFLGRFSSSDLVEFSEVLFIYCSRFMFAPLSNSSNFVGKGELSNLQSDGIVSSRDFNRNYKERIFGLFLCYSLYFLQPSQYVIPISVTASQLDGFYEFLGTVLMPEEHFEAIYCFYRLVDSNAFSVVPLEGNFNPLLQRSLNFFLHNKSSPEVCEVDATDEFGLLFSLSNSDVLKQSESLHRHYISMKAQCNVELPRGAQILNESPMDIVRRLLKETEEIYSQQCTLEEEGSKGVISRRNQIRENAYAQSGKHCLAILSTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0T9</accession>
    <name>A0A914I0T9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0T9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6254.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6254.t1"/>
        <property type="gene ID" value="Gr19_v10_g6254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6254.t1"/>
        </source>
    </evidence>
    <sequence length="834" mass="93863" checksum="4A6241A4A8F366B0" modified="2023-02-22" version="1">MQQQPADNEESPIWAIDLFERRQFRNGSVEAQCMECGKRFIPMEVNTMTGHIVQEHPQYAAKLLAKQLEFGGHQRMPKEEESPIGPCSTSTTVFAAERQQQAILADANAGAKQMSLTLSSSMPKDGLSLDRSSAIAPSPFRPLSPATPEATTNQAAAGNCLGAAARFAFAADDAIGMAPISMVKDEEQPEVGLTVHYHHDETNRRQFDTDMEMRDVSVTTNDTFSSTTTGTMTTGKTTFGGGGDNKAYYVDRFGKEWRLFVFAVDPELLDNFVRQNMLCRSGPPKHDGRIYYSCRWSGRWSPYQNCLHRALYLPGRKALVYRRTHNHPTPISALNANNSGILTVPMAAAQQQHENNGSNNDDNVSAFSAALPDIDNLDNAITTDSKEHVVVAVAVTTATEAISDNRPPPHMDPFGKQWDWLLDLPDVGDKEKIRQFCHTHFLSKSSNYPRRILYVCKLNKRHSLRDFVRCPYRALYVAERGAVFAYTSHNHAPVEDKKCVGTNDTMNSSGISDSIDLRRRDANSSNSTATKNGSQSSFVSNKSMLHHNIKTKQHIDNNNTAQSDTYVAGNGRVWTRLATLDEADGDCTAARQQLRVLGELHRLCRYSLRRNRDGTFHTVGLACSEWRKFHCPYRAIYVVKLRAVFHWSSHDHTTKKPKPTPKLKKILTNKKSGKKMTIKRTKKKAIKRAKNKVVKVKGEPKRHIVRTSTLAPTDANQYLSISKFSSSDHKAPVIIDRFKNLWHWLADLADDSGGVVLDFCRQYYVNKQFITVDEKRVFYWCRYRKAPISCPYKLQRGDEPLYPTAKEGEKTKNNGDHQCCWPHRKQKGGGRASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0V7</accession>
    <name>A0A914I0V7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0V7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5840.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5840.t1"/>
        <property type="gene ID" value="Gr19_v10_g5840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5840.t1"/>
        </source>
    </evidence>
    <sequence length="425" mass="49565" checksum="84D86C6C24CA7F8D" modified="2023-02-22" version="1">MTEQFEPLSDTDEFAKLDRQLEEMKTIRMEESQKSLMEEVEALKKEVTEMKKLKASRKRKTVKTREEGTEEAEKNEKEAKKETEQKSGEKIRKEEELSKEKEPEITILERENRIRLDDEISLNLELEEEERILFSTPRGAENEKMSYWQTCLNRVKSRGELEKGSIGKTKKPTDPIRVAKSEIKSAELSIWQKRSEEIPPEGKQINQLDCSMNTEREENREKFESGKANRSDEKNIFMEEKKSKEAQEITALLLNLREKSLEIHDEAEKIMRKVEKAFEMEEKREKRGALWQQHDVRWPVFERNNRRGSGNWNESRGGWSNQRGARGWRRGRGQWHDRNEWGPSTSQQAEDFSKMAGWVIYGIPNCNFAAHKKAITEQIGRICFDVIQTAASKRAWAYATKTLLSFAFGKSTHALISPATAYLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I232</accession>
    <name>A0A914I232_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I232"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6600.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6600.t1"/>
        <property type="gene ID" value="Gr19_v10_g6600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6600.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10950" checksum="C67EB1DAAF712B0E" modified="2023-02-22" version="1">MIFNNNYTINKTNFFLLNRGGRELKLSLQQIEVLMTTKKEIQICVAIQTKIHRPKISRHNLMLAETFCKRFFFLKLTNAAIFMHVNDGRFATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2C0</accession>
    <name>A0A914I2C0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2C0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6852.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6852.t1"/>
        <property type="gene ID" value="Gr19_v10_g6852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6852.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="39938" checksum="58CAECCBDA529D1B" modified="2023-02-22" version="1">MLTIDLRNRLENIGVKLSLPTLDKYLGQIQATGGGSRKDPFTKELLKALNELNHKMCQSTMYEYLNRLKEEKKAGGGTPNLQAPHATAHLSNQSQSTELWDFSNPAPPLIQAPQIAQQPSNFTSGNPGSSTSASNKGKSTNFSKAPGASSHYGGALPSQQAPPMYGTDVPFQAGIDSTNWLEENSQNDDGSLYSVVNPKTPSSWKNTLGSLSNWFAQQSSNFTSGNPGSSTSKGKSTNFSKAPGSSLHYGGAMPSQQAPPMYGTDVPSQAGIDSTNWLEENSQNEHQTHPTLIRATPAHRRITVARYRFSKPQCRARYSQHSQISRPINQPHLIHPLTLCHPNLERLLWIGAGEIRKTMKEIFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2R4</accession>
    <name>A0A914I2R4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2R4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6082.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6082.t1"/>
        <property type="gene ID" value="Gr19_v10_g6082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6082.t1"/>
        </source>
    </evidence>
    <sequence length="828" mass="92898" checksum="A5BBC4A96ED221C6" modified="2023-02-22" version="1">MEDDEDSVEDEDDAAAFACDIGWVRKTLAKAKADSNRGPEKEKSKTMKRDRDLSSSSARTSVLPEKQAKTSVMEERDVNASLDTDTEAIAILDHHSTRGQEQSKSKELGGDAELVGTKKGAIEDDHSTRGPEQSKSKELRVYGAASNVNESLVADKGEIEILSVRVDRSQPLLAMKLYRTSPLFERILATDAVTADGSCKTGAEYLYDALGLRDYMRGNVAPTGRPVVDSNQAPEMLEGLANKVILAAQSLEKKGEEMQTTNQSVMHMLRDLRDRVGAIETTMKADGQQRGMYQPRGWHDDTFRFSRGGGRGAFASPMAHKLYRSYNSTYSRNSRLIDQFETAAAHVNHNVPQDHMIQPAPPPPPPQPQSQPTALDEQSRVQNMPLPARLSTIFGQFPNEKSGPGQQLTNADSNRGQGKVLEGEIVDTMPDTRAETYQDLDDNYNLRSLLDGFEISNDSVTRETPQENELGRKDEEETIQNGSNLTVPIDERLVTKHHNKTSCCRKRKRDNNGDDKGKHAEESNDDNGEDASDSDVDKDDSDETSSEEEESSSLDSNEQHEQHMVNEQKDKQQEEHKEQHVEQGQETNQPQDHEQHEQHMVNEQKDKQQEEHKEQHVDQGQETNQPQDHQELQKKNEQQDKHGNDRASSLDSKDDERREIDAGTGKDEDGQVGVKAYGVPGQDDPEYLPNEQEQEGKQQEHLERNIEKRDDERTEIVHSTGGLETVGKAAIPGQDDPHHGHVKDSTRGHTEKKAEDPETEYLPCTNPKHIGVILGRNSRDPTVFCYVKRSPGKRDRHTQLKKSEVSEIHRIQELMLARVMDLSKSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3J7</accession>
    <name>A0A914I3J7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3J7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g699.t2">
        <property type="protein sequence ID" value="Gr19_v10_g699.t2"/>
        <property type="gene ID" value="Gr19_v10_g699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054139" evidence="7">
        <location>
            <begin position="32"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="407"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g699.t2"/>
        </source>
    </evidence>
    <sequence length="492" mass="54870" checksum="D185B0FAD2402ADC" modified="2023-02-22" version="1">MNKFNCAHCVVLPLLVLNIIVLSVSVHGGDGVRPCPSDAETESPLVMKRRTTLANLIAIDSAVKKETTLADLIAIDSPARKETTLADLIALEREEEKKNSSAGVKGILSDLLAMERIQEEEFDQFLVNMGEQEQLIGAVFTPQTVKREEKGILRSFLRKKSGKEHHQSSNNHTDLEEKYQILKTMKKNDPAMSQVVEKLNLYSRKIVSGLGRQLKKYLHFTIMFLAKRQRIAATEIVPLKSVSKQSTVAKLIKFCVDENRENKKNETKNEDKSVQTCNSDRSKSNKSKAKRLLQLLLTALGDGNGTANLALEIDDIKRKRRRRKRDFGSLIMMVLVLFIMLSVATHKVGRAIRKCVRPSSSTALETNEVGAAWSSSETGETKTEVLQAFVNLPEHRMRDLKEEVGECAICLDEIDGDEMVRQLPACQHIFHTNCILAWFKQHITCPICRAKVFKTEDGKTEPVGVRQLPTLLQLIETEENAAAAAAAAAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3N9</accession>
    <name>A0A914I3N9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3N9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7209.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7209.t1"/>
        <property type="gene ID" value="Gr19_v10_g7209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="143"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="288"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="357"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="447"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="519"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="591"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="663"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7209.t1"/>
        </source>
    </evidence>
    <sequence length="865" mass="97575" checksum="7720460B03291CB3" modified="2023-02-22" version="1">MPVISVYTHRLGFPILASSIAMASEKKTLDYSVDFPQLPDASAVTSTSASSIGVWAAATQPAIKSSVITEAFKLSAEERASRGFGKTFGTASEEQQKCNQIAKLTGTTIELNEAKDQSITILISGKQKCVEDARTRLVRELQTQATVKLDIPKDYHSYVIGKQGIKLRQLEHKFLCRIHMPGREEKSDTIRIVGPNEYILEAAKHIQGIADEMAKQKTESLDIPRTFYPWIRGINNEKLDELVRRTGAKVNIPPTHANNETIIVTGEREGVEMAAAEILKIFNEKKETVVSVEVTVPKAQHRYVIGPKRAGLDEIFRDTEVLVELPSEDNDSETVILRGPKDKIGDAAGAVYQKASSNIAIELPYKEWMRRHLIGPKGQHLHSLVPNQERLKIDFEDNVIYIEGPTEQVKQAQQQLGAEITRLENEPRYEAMRAAPSDSRPGEEKEPQTKIQLNVDPKHHRHFIIRGAEVLKEIQAKFNCQISFPKQETGDSMVTIRGRDEVVQGAKARIEEIVEDLEAQRQVQLDIDPKHHRHFIIRGAEVLKEIQAKFNCQISFPKQETGDSMVTIRGRDEGVQGAKARIEAIVENLEAQRQIQLEIDPKHHRHFIIRGAEVLKDIQKKFNCQVSFPKQETGDSQITIRGRDENVQKAKARIEAIVEDLEAQTQMQLNVDPKYHRHFIARGAEVLKDIQNKFSCQVSFPKQETGDSTVTIRGRVENVERAKARIEEIIEELFDLYDESQYVVRREEPPPPKPEPNNIEMVNAPWQLDSVEQFPGLSDGGVAAQQQKPVSATAVWGELTNSGSTYIYTVMVNIRARPCRLITMSKIPRVLTADTVSGQDKMEQYMVNGYARIKQKRSLPYNSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3V6</accession>
    <name>A0A914I3V6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3V6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6356.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6356.t1"/>
        <property type="gene ID" value="Gr19_v10_g6356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6356.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15065" checksum="8D0E51A35051CB02" modified="2023-02-22" version="1">MPRPSEGKGPLPVDFPRPAFAADPQVLQQMLSTTFAGIQTMKNEMARMREAQAQAERAKELAEKEVEAAVHEERDKEEEETKPKPAEKQRKRNRSREREKGRSPKWKEEAPDGQSRAGRRPAGGSRGMDEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I418</accession>
    <name>A0A914I418_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I418"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7120.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7120.t1"/>
        <property type="gene ID" value="Gr19_v10_g7120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7120.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7318" checksum="89395E47AB217C88" modified="2023-02-22" version="1">MCMKNWLSDGVFQVQKWTSPASATAHFAVQPSISGFCVVVLLDGHHLLPARVPEGMSFDAKFRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I531</accession>
    <name>A0A914I531_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I531"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10943.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10943.t1"/>
        <property type="gene ID" value="Gr19_v10_g10943"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6875.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6875.t1"/>
        <property type="gene ID" value="Gr19_v10_g6875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041150323" evidence="1">
        <location>
            <begin position="23"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10943.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6875.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22500" checksum="F229AA6739C9BB29" modified="2023-02-22" version="1">MLSRSTLTCVLALACILPVALAELDEIACGESRDKGNNECGESGGRRFYYDANTKRCQPFAYGGCAGNGNRFDSMAQCRQKCANFEPVQGNAGGGEEGHHMVLPVPKCSGGVRAAVDAADAHVIECPGEKCPEGYKCEGKNCCPAAKKIVCNIEYDTGRYAFQGSHTPRYFYKKEVDNCLLFTYYGALGNGNNFENYNDCIKYCKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I545</accession>
    <name>A0A914I545_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I545"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g740.t1">
        <property type="protein sequence ID" value="Gr19_v10_g740.t1"/>
        <property type="gene ID" value="Gr19_v10_g740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g740.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19893" checksum="606068638D2674A2" modified="2023-02-22" version="1">MKSGWVLRSGSQALDNENGGNLDVASMLHIFAPPADDSTNGGNAEDTVDILKRMLVIPVANFSSVERLSPIERVFPVERVFPVERVFPVERVPRVERVFPVKRVSPVERVPPIERVFPVKRVPPSSACPPSSSPVNQHSQMFGLAGKFPRASRQLSPYSYALLSSLIATQCHAYPIFGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I595</accession>
    <name>A0A914I595_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I595"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6910.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6910.t1"/>
        <property type="gene ID" value="Gr19_v10_g6910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6910.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11788" checksum="BD353AF85216D9F3" modified="2023-02-22" version="1">MRTCIKQLSALLRKVRNGGRQLLLMLFGADWVSGHLAHWTFGTLVKKRTFGTLGGKKTFSHTGHLAHARREESIVCQMSVFPLVCQLSNVPNVSVPNVQCAKCPIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5P6</accession>
    <name>A0A914I5P6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Papilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the papilin family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7014.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7014.t2"/>
        <property type="gene ID" value="Gr19_v10_g7014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000017">
        <property type="entry name" value="papilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1152"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1213"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1333"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1442"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1536"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1593"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1745"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1804"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1887"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="1975"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="21">
        <location>
            <begin position="2110"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1277"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1392"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1670"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1804"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1279"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1406"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="143"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7014.t2"/>
        </source>
    </evidence>
    <sequence length="2150" mass="235483" checksum="D9C7A5C0DF11BA86" modified="2023-02-22" version="1">MAFERCKHWQYKERPHKVPSFCDNIALEVEMTSFSAAHWHFVFLLPLLLLSFVPLIALASASSEAADDGAVPLPLHPSSPPHRQPAQQNRAKRQAYQVYLGNEVSVSVDRGQVVDEGPWGAWTVERQCSRTCGGGVYVERRICGGGGHCAGPSIRYISCNLEPCPADAIDFRAEQCAAHNDDPLDGKYHKWVPYAGKNKCELTCRPESGSFYYNWAEKVIDGTKCDAYGQEICVDGICLPVGCDGKLGSEAKLDKCGVCQGDGSQCKTVEGLFDERALPSGYHDIIALPAGATAIHVEERRPSSHVFAIKNATGFFFLNGNFQIQVLDKDIVAGGAPFKYGKGDSGTERLTAQGPLQEPIIISLLLQHTGAKQIAVKYEYSVPLEKDVKFLYKPGEWSQCSVTCGRGVRTRALYCIDTATQARVDDASCEEHNATKPEFEKKCVTVDCEPEWFVGKWEPCSTTCGDRGVQFRVLYCHRVFADGRRITVSDANCTEERQLPRPDMSQQCARWSCPEWQAGPWSACSSQCGDAKQFRSVTCRSAKDGEEGKLLPAEACTGSKPSTERDCNLGPCEGLRFHTADWELCQKCNDTEETRAVNCVDKNGREYPLEKCLDGKKVTKIPEDTRPCASQAPCIYEWHTSQWSKCSTECGHGHTQRKVFCAINELGQTKRVDEALCGQSADEKPVARDECVNEEKCTGTFFTGPWTNCSAKCGGGTQTRTVVCLNYDRKPVPEWCDEKEKPPEEQECGMDSCPKCADSEHGCCPDEETFASGPFLEGCSNCSVSDFGCCGGDNMTAKTDEAGTNCKEFTEPLGGEEGSGEEPVDAEASSPTDGKALCEIVNQDTMEKFQIPCADTVLAAANETVELLKMAEDEAIGGTNATDGEKHCSKSEFGCCPDWSTPAEGPNYAGCPKFVLGNCNGTKFGCCPDEVTMARGLDFEGCGEPTCAASLFGCCKDRRTIAFGPHYAGCDRSSFPCELSPYGCCEDGETAALGNNGTGCGASCLLTKFGCCPDGKTHAKGTHNEGCGCEYAQYGCCPDGRKAATGPGFYGCPEGCAQSKFGCCPDGKTIARGANKEGCPCQYTRWGCCQDGETTALGPLNEGCDDCRYAKYGCCLDGVSKAIGPDYAGCPTTTAAPFIIGGTVSPTQIVSCSLPQDQGQVCHPGYQLVWFYDIAEGRCSQFWYGGCAGNNNRFANREQCEQSCIEPPHLGRCYLPKVEGPQRCTQLAARYWYNYVTKQCQAFWWRGCLGNANNFGSWEECQKFCELADATQVQVVMPQPQPQQPPQPPQQQPPPVAPPPVQPQAIQAPLQPAPQTVAILPPGLEEAGELDSCRLNVDSGNCQNYMDQWFFDPYSGACFLFIYSGCGGNRNRFGTEAECIRQCGHLRKPKPGFLGQKQLPPPTPAPTAVAVPPQQQQQQQHKPKVEKMTTGRKALTKSRDVCNLRPDIGKCEGHFESWYYEVASGQCEKFEYSGCGGNANRFNTPDECQAVCLRRNDFPSPQRPGGSVSAPAPLGPGNLEQSLPIIGDKQHLAHICDVPKDSGACKTFITKWFYNMRDGTCVRFHYGGCDGNANRFDTEEQCKNTCGNYKDTCHLPKVVGPCEGHTPRFFFDLHNRQCLPFEYGGCLGNNNNFRTLEECQARCRPSTTTTNPSPVRLTRANPMPVTTAELLEDDDDNDQNRRNDQTRPSQQPGGDQNDHFDQSAVNGGIVNEEEEQDEQQQQHMDEDMVVVPREHLLYGQLPELCLLPEQRGTCFGEQLRYRYDTSAGDCVGFLFSGCAANANNFASYEACARACGPWKAEPVCEQSPDEGREQCNNGRRRRRRRQNDMAGANVPKWYFNAALGKCALFFWSGCGGNGNRFQSKSECENLCQREILARTHRRTGRACAQTMDAGPCEDLVTMWYFDAVQEQCRRFTFGGCRGNANRFVARADCESQCVAAVANTSGDSHLNANDNFGVPQHLSRQSAHRHQHRRPRLFAFPVGTLLVGTSTLTLKCVADGTATPKAFGGNEANGEEEEEDNNFTWYKDNQQMLTTQADDATEQQQQEQRVKFFESVTTHAGGGEAAVVGELRFRSVRLMDGGAYSCAFGDASNALISEPVIVRVTEADPSLTLCPGDNGPAHICRTVARTGLCSTLRYGRYCCRTCAIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5V5</accession>
    <name>A0A914I5V5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5V5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7797.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7797.t1"/>
        <property type="gene ID" value="Gr19_v10_g7797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000003">
        <property type="entry name" value="Iroquois-class homeobox protein IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="260"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="262"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="626"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7797.t1"/>
        </source>
    </evidence>
    <sequence length="710" mass="78196" checksum="9FBEE149A0C9C100" modified="2023-02-22" version="1">MSGASELAKVPPPPPPPSSSSSSSPSSSSPNVEDGRHQQRQKPQQPTESSFRRALQLIGPSRGHRESADVKRDGGGEDEEPNKDRHQQEKMPSLPAVVPCPSSSSSSPLCAPMDHLSQLVASFAAAHHHNLQQQQNAAPSHGRPPPMPPFLPNGAQFPSGPFPSAAGLPLPDFNSLLAVAPPGVLGPFIAGGVAGAPFLPPPPEMLFAAATHHNQQQQQQNNGTAINNAANNGMPSGAPPGLFPFPLDPVTLASLQPFMVPTEIRRKNATREVTAPLKRWLNDHRKNPYPTKADKVTLAVITNMTMTQVSTWFANARRRLKKENKMTWSPRNRPNDEDDFLETDDGMKAQGATAIGPEGSSSPEMELEEDEEDQPQRHRSISDMEQQKQRQRGGIWSILDTLRQEGRDGSNDEGPGEEQNGTQRRPSAEKDCESAGSREKDKEFKTDQHDLQQRIKHDQEFKTDQHDLQQRIKYEQEFKTDQHDLQQRIKCEHSPHNHQQRPESPRNGLTVHSNALPPRSPHSVPSGPHAPPLDFLIGSAPVPPPHQLMLPLPPDLSNARHHLLFAFQHQQQLHHQRNLLAAANPVMAAMILAQQFAVHQQQIGGTADGGKQMDGAVAAPIEAEHRQQRLREDGPEEQRQQQQRQQQHEQQRNGAGLLPPQPPFVHLHRRSAVSPTSSILVGQKRAAAPMPADPADNGIRLTKRECRAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7D9</accession>
    <name>A0A914I7D9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7D9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g819.t1">
        <property type="protein sequence ID" value="Gr19_v10_g819.t1"/>
        <property type="gene ID" value="Gr19_v10_g819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g819.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12338" checksum="EB18F0513F0BD69E" modified="2023-02-22" version="1">MQVVHQQNGPIEVQNAIILWVEAEPFRCCTHVLPPSAHQPDSHSLAAPNVWTARPSPPQSPASKGKGQGSATETVQEQGMDLFETATAGLSLYLFLFVNLQPISLYIFVTRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7P3</accession>
    <name>A0A914I7P3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7P3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7512.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7512.t1"/>
        <property type="gene ID" value="Gr19_v10_g7512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="164"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7512.t1"/>
        </source>
    </evidence>
    <sequence length="531" mass="59572" checksum="8DB88DBCDE642310" modified="2023-02-22" version="1">MRPIAAVPSPFLPLVVAFGLFSTGSVSYMFLPATRQLFVNPDILSSDAALTPRGFHIADFLGPNKRFLDGEAPPATIFIGPKERRAPAERSFGEESQWLKAMDNLRKPRFVAITVFAVITNVSHAFIVARMVNDEVPAQCRILNHETVPDDTVPDTITVNGIQYRVYGQIQHGATSRVFHAVERMPTAPEVRCLAIKVVDMAKVEPEKENQLNNEAAILRELNARGVRRIPVLYTMEHNPSKSMSMVFELADHDLFDEITPKMGSHDHRWVRRTFHDILRAIQPVHANEIVHGDIKPENMAYFKPISGSSPGGADQSSDLVLKLIDFGGAMRARTLDSACEEIVTGTIMYMSPEQMAWCGQRRNEFVDKRREHQMSEKSDVWSVGIILYQMLYGHSPYANLLHQFDAVEEEAERAERTDAALRPAILHGTEPIKFGQYDDGAVLQILKKCLERCPEKRPRIDQLLAWMQQPYGPRLSNFGTGKRNDFAGQQLDTHQVQAGDGPAQVGAGPGDAEKLFGNKIRVHFKDILMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I833</accession>
    <name>A0A914I833_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I833"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8350.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8350.t1"/>
        <property type="gene ID" value="Gr19_v10_g8350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000060">
        <property type="entry name" value="Protein CBG03800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000058">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF124">
        <property type="entry name" value="FI05614P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="148"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="313"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="461"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8350.t1"/>
        </source>
    </evidence>
    <sequence length="643" mass="74935" checksum="352A15F900925C77" modified="2023-02-22" version="1">MSDMQQWRLLCSRYQVAQAYMEDVNARVTVFAPVNDVFLYNPDLRAMDQKEVLSHIVDTQIVEISSGRRWEKQTLIRSTINSGYTYVTQFENGPGNFSYFANAGTICNHVTNQWGIISGEQYLYKTCTPMGHRPYPGTALSFVRDDDNAIFVDRHYDNRDLTELRDILDRVPDIALVIYGSSAWNGFHTFFLPNNKAFAKVIDRNRVDREVFQSPVTLSVLFTYPWLYDGAVHYYPSIRFSSNIIEDNFKLKLCMRNITDRRTGKWDLYAVSSVYERYGQFRRGAVWAKVLVPNIPVQNGVVHVVDNVLGIVTNTIDQMMMDNYRCTTLMRYMNTIGQIVRNYFSATGGLVTFFAPWNEAFERIPEPIERRLLRDRIWLEQILKLHIVPAKELTTEEMTNETIVTTVDNMRHLYFVRGEWPKNNVTYYVVGGGIRTAIQMEDVTAVNGIVHYIDRVLGVPYQSLWEILRNESRAQRSYEMLNNLQLKYSLDPWQVLTPEQNFTFFVPIDEAWDKVTPTLKNRMLDGNHWQALQYVYKRHVLQGQALMYTDLRERTYVMMNDEKVIIRRRGRYFELYWPRGNRVARVLEGGEIAGINGFIHLVDGVLIYEPDLRAAALVGASATENHILLLCLAISLWTHRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8P7</accession>
    <name>A0A914I8P7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8P7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7935.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7935.t1"/>
        <property type="gene ID" value="Gr19_v10_g7935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7935.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40789" checksum="7A0A9905D7777B68" modified="2023-02-22" version="1">MSDNPKKVEKRLKEIFVCDDVLFDVFKFCAPVVLGLNVALISDRFDHLVDAHFKTKEWSLGNLISHRAADGNGAQFVKFTANGVMRRLSIPHESLPDNVGFEFLTISYIDKSVIEFLRSIRRRFDSKGIILCMGTESDQNRSWEIIWHRIWPLINDNIRVFGFYSSNLGRLRLLSPTVLRDCPKLRVFGSRGSLEFPADDSASATSDQAMTKWLHTPCGDGLPPKVLQCRFCLERMEGLKLAFVNSTYPINFIICFRNRSYDNAFVPVPFELKNNLTRERLVSRRFDEYKWLLVRCPIERDEDKWAEWEKEATEWSQCQWNRINIELKDRDIGDGMLDTNEGPSEPKKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB05</accession>
    <name>A0A914IB05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g830.t3">
        <property type="protein sequence ID" value="Gr19_v10_g830.t3"/>
        <property type="gene ID" value="Gr19_v10_g830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="557"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g830.t3"/>
        </source>
    </evidence>
    <sequence length="755" mass="86055" checksum="13DB150A727EC21E" modified="2023-02-22" version="1">MAQINLTQNGGGGVVENEDVLPMQNIGGIGEDVIGADNGIMDLDSSIAYYTPLSSPQSAANSTPIPIMQCSQEERPNSRQVVETGLETGGDRAPTAPDCTTNPQNGPAGQEGTPATAPARRVLRSWSENDKICLVVTRKSCLNSCVCSWKKFHVDHWIPLWTEESVDSLRTNLTLCSQYSNLLNRTTISYDIDNWSYRMNASNLRCGLSLRPEQSPVSQEAEPANPQDGVSEAVEEPVIPSIPGAVEEARPIQVELENGTKGNEKKSKYDEFRLIFVHVFNVISREKSAKRKALLIPSRISDEEWKWCDRLFRRYFKSRRGNTTLLRVNQVLYAIGKALEKREAARRRGHMESRQQWYRDQRREISRLRCHIGWITDELNRRKKGEAPTRVQKRNFHAIRHRYAENGKAIRTQHQLERRCESLKGQLALAIDRVRLRQTDEDRKRIRFAPVKRIIEGKPMPSVLDSVECVRSYWQKIVGEPKGFIKTANMQEWQNKLPQIPGQNLTESTHESEYEEWLKVVAKVRPRKAPGPDGIPNLLWKKITPANRWLFEWVMQIREKRCRFPKWLTKGRIVLLPKKPNAQEPGDLRPIACLNTCYKLMTGLMTRWLSRHLNTNGLLPVTQRALVAGEWGCTHSQVLDRTITADARSHGRQLAIAWLDYSKAFDSVPHSYIHHILKVLNVDERLRTAISDLMAGWEVIYELRTKEGTKSSVPLKVQRGVLQGDTLSPLLFCTALIPLTSTIDGDENEQHFLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB61</accession>
    <name>A0A914IB61_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB61"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9219.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9219.t1"/>
        <property type="gene ID" value="Gr19_v10_g9219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9219.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27810" checksum="5FAC4B9BB96A9FDB" modified="2023-02-22" version="1">MAALPAVACASLTRTPLAAHLQRVRSAVQLVWERRGRRKGKDAKREKCQKGKREKMPRGKSAKDENVKRKKWKKVKCHGGKAKSGEKCQARKRQKGKCQEEPVPKEKMQKGEMPRGKSQKRGNSADREKCQKAKCQEGTVPKGKVQKGEMPRGKSQKRGNSAEREKCQKAKCQEGTVPKEKVQKGEMPREKSQTRENAKRESAKRFQNQIKFIDEMASECAACPQQWPTGHDILWIIGPNANVITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB84</accession>
    <name>A0A914IB84_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clarin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IB84"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8345.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8345.t1"/>
        <property type="gene ID" value="Gr19_v10_g8345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026748">
        <property type="entry name" value="Clarin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548">
        <property type="entry name" value="CLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548:SF1">
        <property type="entry name" value="LD47387P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8345.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26377" checksum="01B1B98286EACAFC" modified="2023-02-22" version="1">MSLLRERLSVFSALFFFAVSLALTLSALLTDFWIQADAMRRNGTESNKHQMNSGLFHGIRQIDWTFGPKRKHFSVFDEIQSDISFMDRNVWFALLLFTGLGLLWNFIYGESTQPLERWAFACGALLRVSWHCDGGICLWGTLTIVSYGLSAALFLWQFFVRLRHNVLLPEHIEAGFSSDGCVVLGFSFWLLVNAVSAQLIPCILLFWALNGRGKRTAEEEKSKEQDSVFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBC9</accession>
    <name>A0A914IBC9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8375.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8375.t1"/>
        <property type="gene ID" value="Gr19_v10_g8375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8375.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40113" checksum="2E35B4B7DC429BC2" modified="2023-02-22" version="1">MSDNTREGEQQQQMQEISICDDVWLEIFALISPLELGHLMALISDRFDALVDVHFKSRKWSLGSMAICNATDGNGAQITKYPSGRLPIPQGPMPGKLIGFEYIWISYVDQTVIEFLQRIRRLFDSTGTNVEIHTFVSHRRSWEIIWQMIWPLINDNICRLLLSYSDQLDRLRQFSPAILRNCAKLRLIDSIEHFPDFPAQDNADASSSQAMAKWLLTPRGDGLPKMLLSWFYSERMEGLKRSFVSASAPVNFIVRLLSYSLGREPFELTNNWTGERLTFRRFDKCYWLLVRCPIVREEDKWTNWEKEVIAWQWRRQWNCVHINVNGLHIGDDLVDAKAGPSEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBK1</accession>
    <name>A0A914IBK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9326.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9326.t2"/>
        <property type="gene ID" value="Gr19_v10_g9326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9326.t2"/>
        </source>
    </evidence>
    <sequence length="167" mass="19491" checksum="245329FE7A27D9D1" modified="2023-02-22" version="1">MAAFPYEINADMDQESVDLREHNAEYVIDQRLYNALIPRCLNHRDRDEFGYELLDYSDFFDPTDEGDRICLVSIRARGVDSRQEVRSFFVNNSPAINTRYNCVFSFHELPLHEWDIAIVKFLGDTKLKMWEPLLGHIYEILKDFEDGRVPSQILANSDSPPALDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC43</accession>
    <name>A0A914IC43_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IC43"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8569.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8569.t1"/>
        <property type="gene ID" value="Gr19_v10_g8569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="35"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8569.t1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40063" checksum="185CBED27A00B1BA" modified="2023-02-22" version="1">MLKSSFVRGKCLLSSLPLRAFSVSAQCASGEPIRRVVLIPGDGIGPEISSAVQKIFEAAKTPIDWDPVDVTPVRGRDGVFRIPNKCIELMHENKVGLKGPLETPIGKGHRSLNLAVRREFNLYANVRPCRSLEGHKTLYDNVDVVTIRENTEGEYSGIEHEIVSGVVQSIKLITEQASRRIARFAFEYARQNGRKLVTAVHKANIMRMSDGLFLKMCREQAHEFPDIKFKEAYLDTVCLNMVQEPNRYDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGEGAAVFESVHGTAPDIAGQDKANPTALLLSGVMMLRYMGLESYANKIEKACFDAISNGGHKTRDLGGTGTCSTFTDDICGRIRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC91</accession>
    <name>A0A914IC91_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxypeptidase</fullName>
            <ecNumber evidence="5">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914IC91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8872.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8872.t1"/>
        <property type="gene ID" value="Gr19_v10_g8872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF418">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038159320" description="Carboxypeptidase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8872.t1"/>
        </source>
    </evidence>
    <sequence length="478" mass="54035" checksum="F668809B88AD426C" modified="2023-02-22" version="1">MFSAALAVHLLFVLVQAQFGDNDNLQQPNGLENNFDTEEDEITDALPGLSFELNFKHYSGFLKDPSNDPLVFWFNGGPGCSSLDGLINEMGPYLVNPDGRTLRENPYSWNRFASVVYIEAPAGVGFSYATDGNTTTNDDLTSLENYEAIKQFFAKHPSFRKQNVFITGESYGGVYVPTLTERIVDGQTEFPINLKGMAIGNGYMKANLNIDTSARFAYGHGIIDEKIWSELEQRCCRGCIDGCDLTELKDSCERMVEDIFEFLWHGGLNPYDLYRDCDPSPGRNSIRMEVLKRGLVPPKMLRRFFSNATRNLRRRLQESVQGGQNFGTPSVPCLNDTDVTTYLNLPEVRKALHVPDNVGHWDICSEDIADKYQQQYGDTSPFVKKILKAHVRVLLYYGDTDMACNFLLGQQFSAQLGLKPSINKQPWKFGRQIAGFKTIYARGFLTFITVRGAGHMSPQWRPQQMDYAFSQFLLNHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICD3</accession>
    <name>A0A914ICD3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heparosan-N-sulfate-glucuronate 5-epimerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICD3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8902.t3">
        <property type="protein sequence ID" value="Gr19_v10_g8902.t3"/>
        <property type="gene ID" value="Gr19_v10_g8902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047464">
        <property type="term" value="F:heparosan-N-sulfate-glucuronate 5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010598">
        <property type="entry name" value="C5-epim_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039721">
        <property type="entry name" value="C5-epimerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174">
        <property type="entry name" value="D-GLUCURONYL C5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174:SF3">
        <property type="entry name" value="D-GLUCURONYL C5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06662">
        <property type="entry name" value="C5-epim_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-glucuronyl C5-epimerase C-terminal" evidence="1">
        <location>
            <begin position="333"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8902.t3"/>
        </source>
    </evidence>
    <sequence length="530" mass="60948" checksum="930C8DEFF0E27FB8" modified="2023-02-22" version="1">MPPPVRLLFLVPRRALRRFCALILLLVVLFPLLMLSGHRFSLGGSINQQINNEKGEFQPPLICAKQKAQFEFWGHTGCGKLREMALRERVACIDPITGVPMSKQWEKVPYFYPIQIFQFGLGHYNMNRTGKMAVVRRLAKKVSVRRAVGAHSEGRRAHANDGNGTITLDADESVQVKLFHWLPILLFSLETRRIDSEFVLKLERRRNEGEPRAMALIFRHSERKGCVWKDELRKAFPISVVFNIGPNSTMRWLDFVIDIRVSAAKALNVFCEGRNKFTKRELCQRQNATAAEFLPRELLFRGPCRVRIHSLRQQSNAHSEMFHKVVHWMLSRQDERGGWPVPISRTITEAHHRLVLPVGWQSAMAQGLALSFLTRAYTLAKVGERDLYMKAAQKALDLFEVPVEKGGVLSNICGLPWFEEYPTLPGTGVLNGFMSQALFLRGLDSLRHLLHLFDGGWWSLYDLRHIHLDSPPNLASQDYHLLHVSQLRWMYSITGDPYLEETAERWEGYAKTKCKSETSKIGWRQQLTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICK9</accession>
    <name>A0A914ICK9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICK9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8647.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8647.t2"/>
        <property type="gene ID" value="Gr19_v10_g8647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="733"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8647.t2"/>
        </source>
    </evidence>
    <sequence length="896" mass="99224" checksum="3EC97C9D094B5B35" modified="2023-02-22" version="1">MPPSLNAPLVQTKRATAKKKEEWTASDVQSQPLCQRISGGNNIRAEERKREKYSKKDETDGWRLISVDDAIQRFEPGQNSVARAIETERCDNIVEECWENRMSVSEVEPLDEENGTTGADEWFLETKIIPLELLPADDDDDQQMQQAEFVESVADGCSVAADEDPVEPDNHWRSLDGENRTQQLLSDIGATLGVPEMTAEEKANALERCGTKTPRAPLCTEVSDNEHSKEQPMDREEEEATTSTDPSDMNYIYHQSEPEDSEDSNLIGLGSTLVTELDETHGIDSVTTHELPTENGGEEDIIVLDGDQTGQEEEQNVLPTENGGAIVVNGHQTGQEEKNVSNEEEEQEEAHAEHAEEGEIEEEEDDDEEEEEESVLPPGLFVDSSGEDNENEVSSATPQHTQHEHSLVDLTELSPSRRARPIATTALTLSPQKANSNGQDERPAVLEARQTPPTSVLSSPIREVCPTTQSPSKALQKDRRTSPAQTSVPSPRASSPPKGKRTRSKRKRSKRSATPDTSKVVNQLLNAPSRQPIVHDVPKLTANTYRRGRADPDWWLNTKQKKRTKKQKKRELERQRHKNIEVNAQLNQTAGPSLTAPLPVEPLLSTPIGMDICSPQKSPPPRPPHPIPPPPPLLLLPLPQLIESVPMPSKLFQICGRFYFKNSPEPRIPVTDVRLHPFVTDCHHLFTHGNCSFLTRCKFSHGNFEQTTGWLNALMQFKAMEESLRSPMARASKSPTASPTARSSKSPTAYSRHSNSPTARLSRSKLPKAYSCRYRNKSPKLQPVDIGPLPSQQITNGTLPPSQQIACRTLLSKPIAYGAPLQKPHQIAYGAPLQKPQQIAYGAPLQKPQQIAYGAPLQKPQQIAYGAPLQKPQQIACGAPLQKRQQIACGAPLQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICY0</accession>
    <name>A0A914ICY0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICY0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9054.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9054.t1"/>
        <property type="gene ID" value="Gr19_v10_g9054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9054.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="28804" checksum="DBC9E013737CA02B" modified="2023-02-22" version="1">MQETHIVLGIASVCSLLAIIATVTTIPSLYSQMNEISNKVHDGVEVFRVNTDSAWTDLMDVQVSVTPPSKPRENPFGSIFRAKRQLPGHCQCGPIAQPSCPPGPAGPPGPPGHPGQPGHPGGPGQPGGPGQPSAPCPAQAVACPKCPAGPPGNPGGQGPPGPPGGSGQPGAPAHGGGQGPPGPPGPQGAPGQAGHPGGAGQPGNPGAPGTSSKSVPGPKGPPGPSGQPGHPGGPGQAGHPGGQGPPGPPGAPGHPGQPGGPGHPGEAGASGQPGKDSAYCPCPPRSSVLAISRKKMVAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDL0</accession>
    <name>A0A914IDL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9242.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9242.t1"/>
        <property type="gene ID" value="Gr19_v10_g9242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9242.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28381" checksum="11C5BEB535BDA75D" modified="2023-02-22" version="1">MEFDRISDKEEFDNGKDAEEQSTDSLFDNSNLKESSSNSQKDIKKMYSKVEKQEIIAEFYKLKKEFKSRAKGMSYDMNKIDKKIAQSFGVSRSTINNWKKKFGFSKNKKKYTNAEKWELLKNFYKIKKENPQLRKDKIAQMLNIHISTLYSWERKSKGSKAGIKKIYSEIEKQEIIAAFDELKKEFKTRAKGMLYNVKKLEEKIAKKLGVALRTIYYWKKQFEIPKNKRNALTLNKVEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDT5</accession>
    <name>A0A914IDT5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDT5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8969.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8969.t1"/>
        <property type="gene ID" value="Gr19_v10_g8969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037793743" evidence="1">
        <location>
            <begin position="26"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8969.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36200" checksum="9BC57C3AF58EDC8B" modified="2023-02-22" version="1">MFFSSSKLVLLILTLVQLAIEQCWTFSFVHRKWDFLLPRDLMEKIFALEADAELDKMEVERLTDQLLKEVPRSVLEQLELPRFYSRLPFNIRWQIKELLFDKSLVWSQKHEAIFALIQTLPSQMRRFAPIQHVAQSSVDDLSFARPTLAGTGHSRLFESLSALKYTVSFTFQTKELCEILPQPLEAQLYTALSSNKLNIEQKLAAVENVMSELPFGVLDRLFFVGVPIVDAEVRERFRRLWYDRPYWSSDAGEEEGIGLKMQNSNNVDSPMLLNLPVPSSSAQQDPIGRASIFYQHQLPSSQPIIPPLKPPKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE12</accession>
    <name>A0A914IE12_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9021.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9021.t1"/>
        <property type="gene ID" value="Gr19_v10_g9021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9021.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15168" checksum="CA70EE4F0DF830A3" modified="2023-02-22" version="1">MVTSFAKIVANVLIVGIAFYFLIFKGSYENLRDPFANSTFAAGNLPADIFLLLLVNVICLRLFRLLAQSMTVRRPHYLFMCFWVHFFLCRQHGTADGVSRLCTMASTGLHHVRIAVHPIWTFARSSSGKKKTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEI5</accession>
    <name>A0A914IEI5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEI5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9168.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9168.t1"/>
        <property type="gene ID" value="Gr19_v10_g9168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036880313" evidence="2">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9168.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33429" checksum="7D5B39D3883D7ACA" modified="2023-02-22" version="1">MVYNFSLLIALLSITFATRTIAEDVRQLKVSIYPPPVADDYCYQVAIYCNSSDRSEGDAGPTVKLITVQTLLGKMMAQQNVMEGQFSENDEQTSNNASTGWSTVEHQSQDIVERKKADYTIKCKANERLKQCANNEVFIKIVKILEVGPARNNEEKLLTLKTMTIAQFEGTNQFMFDFEKEYRKTFKIVSHMHNKLYEFTVRVKKVSGANNQGFLLQQNFVVYHKELRGHTVDVTVPITKAHKISERRGDIEIKINYKKNDHGDGKKDETIVKMYSIDEKMWNEFETFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GP18</accession>
    <name>A0A914GP18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GP18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10027.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10027.t1"/>
        <property type="gene ID" value="Gr19_v10_g10027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037341010" evidence="2">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10027.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17951" checksum="18D743582B95E3B8" modified="2023-02-22" version="1">MKLKILQLICLINYVYTFPNDLFDELWETNQSEAQANSIESRPKIKIEPREEQFNERWRDESSLKGIVKVEHEPHYGAVKVEKQLEDHVKEEDQHGQATNTSDYKKIGDNSNKHLSDQNNSTDHDEIVDEQQNESNEYAVIADMLKISTGSLNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRS2</accession>
    <name>A0A914GRS2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CARMIL pleckstrin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRS2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10153.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10153.t2"/>
        <property type="gene ID" value="Gr19_v10_g10153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041245">
        <property type="entry name" value="CARMIL_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17888">
        <property type="entry name" value="Carm_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARMIL pleckstrin homology" evidence="2">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10153.t2"/>
        </source>
    </evidence>
    <sequence length="1171" mass="128262" checksum="DCC2105A126F2BA8" modified="2023-02-22" version="1">MSSLNREKADEICKHIKENSGAIFGQKFWECRLACALLAQQKADRWEPRFMAIAKFRVFILHGKSVNSLKIEKSFNIVALRYLELLQQDHQLQFGWEERVAKPSVVPPMLHVLVRFPDDETEERQQHHAAAVRELALDLLATLKHYFPDIHRSLAKHFLTITPSLVADFPSLPNSVPELPCHNFRRSYVAHCDCMEQPFRDEVIWDIERIYFVHGQHELDLNDFSHLPAKDLQALIGAVQFSDFFTGLSANALRLQPEHVDALVALLRRSHSLRSLRLCRCTTPKDFVAQLAAALALNQTLPLEKLRLSELSLEDKKGLVQLGTLLPQLPAFHTLFLTDCALNEKSALCLLHAFHHGIELAAESARAEAAERRGSSSNIVDHTAAKAKRLSSSSSAASAQRFQLRALNLSGNQLGTGAELAEQLANLVALSGGALRLLDLSGTAIQLDRLWSALKLGGLGLEVLRLGACYCTPSSSKRSGSAKDSAQVARELFTAAHSLKELNLSGTHIGPELLQGILSGLSANQNIAAGSLHFCLDSAIVGSAACVSVLEQHIGGCDCICSLSLRDNALEHEAFRLLSALSRTTNLRILDIGGANFFALKTAKKHAQVLAGILAELVKLINGVGEDEEGSFIEELSLADARLGPHMSVFLNALGLCGRLKRLDLSNNELGPAGARLLCKSLQLNHALRWLALDRNQIGPDGFAELARALRVNIELDGLQMPFSDAAECVVSMARLPSERARFQLQMEEIEQYLERNQKIRALSPTMETIPLGHFVLKTIHKLNNFCEHYGLDGSGKDAELKKIAFHKIGKLITAQRSDSGTGQPCADDGEICGVNAGHELKMMADQLAERIEHVADVDSERFLQKFALLLADQEGVQMHAQEQQAAIDQQKCITNKRLGAALREDLVTLMDKYQKEFAWSHLFSTVHHCLLGEDAQEMFRVEEKPSASYSTRTRKEVTFRNGTHSHRPESAMMSNDDSAARSTAADAMAAVLMSRSVMGDFAHANNDGQHKKNKYGGEAPGAANLVHLAKQRPKPARLNRSRIQPTAATRMDDNDGTKPFSVLANGHISSAGDCVAATTLAPSSSSPSMDSANLLNSSNSDGSPPFVHPTASSPPMVPPRREKMGCSSPMTPPRLPPKPSSPGGREVDERAKRKLRNEEAEPSSEPGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT42</accession>
    <name>A0A914GT42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GT42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11129.t3">
        <property type="protein sequence ID" value="Gr19_v10_g11129.t3"/>
        <property type="gene ID" value="Gr19_v10_g11129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011:SF6">
        <property type="entry name" value="HIGH ZINC ACTIVATED NUCLEAR RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="439"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="514"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11129.t3"/>
        </source>
    </evidence>
    <sequence length="1084" mass="114618" checksum="D2D6E480F6C13430" modified="2023-02-22" version="1">MADLVTTNSAGPSTSGGEDQLQKAQPANVCVVCGDESDGRPKAMTESKQYASSIASSVSKQASSVSKQASSVSKQAVLASKQASSVSKQASKQAVLASKQAVLASKQASSVSKQASSVSKQASSVSKQASSVSKQASKQAVLASKQAVLASKQAVLASKQAVLASKQAVLASKQASSVSKQASKQASSVSKQASSVSKQASSVSKQAVLASKQAVLASKQAVLASKQAVLASKQSSKQAVLASKQAVLASKQASSVSKQASSVSKQASSVSKQASSVSKQVSSVSKQASSVSKQASKQAVLASKQASSVSKQASKQSSKQAVLASKQAVLASKQASSVSKQASSVSKQASSVSKQASSVSKQASSVSKQASSVSKQQASKQAVLASKQASSVSKQASSVSKQASSVSKQASSVSKQAVLASKQASSVSKQASSVSKQASKQAVLASKQASSLHFGRFTCRACAAFFRRTVSLKLQYKCKRQGNCEVDKAARNMCRACRYQKCLQQGMLTTAVQHSRDGIGKRSRSGQRERVFISSSHTPGDAKMPRGTSETKKQTQFLGIGYGRAQSPSSSSTILLDQASTAATILQLNAVSGQISTTSTFGPQQQHYTGEFGGGVLPPYIMGNFPNLLGQQPAGGSVNLGGHGSLQMTAQLQQQQCTSSAVAVELKYLRRMLDGYHHFLSLRKASYTLVDGFPLSRRDNEDCPQSNFGTSKKICKIEASLIMDIVEKFFHPFSQLPTDDKHKLFNTYYCLFSNAERAFRTYKMFGADDDRLLMPDGGYVRLSELQKFYENNTLVRGDPSQVAKIFENAMHYLVKTVVAHMRHIELSEMELIALFGIFIWSDSEEISHESLQTALQGLSEAEVTLKTANVFLLIPKLENSVRFLREDFNIASIFGMVTNCNGESGREEFGGGPETSANASEVTDGRQQVAAIAGTSRGRGPSVCCFTKLADLPSALFAVASGAWCSSSAITMIRDRAVGLPPPLSAHSSPLSRRLPRCVRVQHDQRLLGLPGLKSPVVSRRRGRKAKRLYVEVLLKMDRRCTFGTGKLGRVTPRGAGTSSGARSLAAAVVECAVLWPVLFGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTL8</accession>
    <name>A0A914GTL8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11234.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11234.t1"/>
        <property type="gene ID" value="Gr19_v10_g11234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF43">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11234.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18575" checksum="7C3C3976BEEEF8AD" modified="2023-02-22" version="1">MPKMDMTFHFRINEFILFREWLPQSLIAYLFSLLAVLVLSIAEKRESQEQCCLVESVSSPSAIVGAVSSSSSSSGAVCNCLSPEFFYNVPLWPFSSQLIAGYHLLQSLLHFVQFFLGLSLMLVAMTYNVPIFITLLVGHSVGYFLTAPLYRHGLAEENRTGGECCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUA8</accession>
    <name>A0A914GUA8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUA8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11287.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11287.t1"/>
        <property type="gene ID" value="Gr19_v10_g11287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11287.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27019" checksum="F10B030EABC99798" modified="2023-02-22" version="1">MELGDSFDERILPLLLIRRHIRLGMGYLFQCLDPSPPDESVRHFWHIRGVIIDVAVPTSSSSTAHQQQQNNSPSTDTLHVETNGGQRINRKASEQKHSNSPKRRPAMSKRDKVQRLPPGVLYVYEGRLVYRGRRWGRWCVWHRELDELEVELCDINDVNVVEEFVSQKDNRSIRCAGPLVDVLVSSSSGGSHFGVLTDSADVIGKELRDTFQRHRQRPRIFQFNSVDIEGVEIDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUE7</accession>
    <name>A0A914GUE7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunit 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUE7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11295.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11295.t1"/>
        <property type="gene ID" value="Gr19_v10_g11295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11295.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20871" checksum="8C8E848ACF577E8F" modified="2023-02-22" version="1">MYAYHHTTRFVYPFLIGLLNCLFWYLSNRQLLRTLISIIKLRDGSGKIVPAEEEFESEELEKVHLSMGLARKRFDNCMLNSEGADFSDSVGARRPKRGFKANEIFEAEPAGSEEEETLEQRYNRLNREVKKLAAEVDKQQNDVSTVKREDICALDNLLKHIASRCKNGQQNVNKGSSEVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUF6</accession>
    <name>A0A914GUF6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="7">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 7">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914GUF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11300.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11300.t1"/>
        <property type="gene ID" value="Gr19_v10_g11300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000092">
        <property type="entry name" value="Leucine carboxyl methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF33">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11300.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37466" checksum="5463D82A5CE4DB52" modified="2023-02-22" version="1">METEADFGSGMLRTEVSHRRRSASVSEDYSVQKTNDDATECKFVAAQLGYYNDKFIPAFIHACTSEKPYHRDPEITRGYWARTSAITSVVVQFIQLAGPSTQILNLGAGFDTLYWRLKDAGLAFYKFVEFDFSSVTAKKICQIKRNKNLNLMEFFSKSAEEKQHSDLHAGDYHLIGSDLRQMREFDGKLATADLDFSQPTIVIAECVFVYMDEGRSHELIEELAKRFETIAVVNYEQVNMTDTFSKVMSNNLNSRGIHLPGLSACKSLQTQKQRFLSTGYPYVQAWTINQIYNSFFQKHDVSRVESLEPLDERELLTQLLEHYCLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV81</accession>
    <name>A0A914GV81_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV81"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10710.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10710.t1"/>
        <property type="gene ID" value="Gr19_v10_g10710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10710.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35286" checksum="5DCD5DC6D17C2C53" modified="2023-02-22" version="1">MPKSVVFKPENSKRKRLTSEEGSDDSSSIGLKKKRGTTLWPTQTSLMPREAYNFCKSILELEETKNIDLSRLKGNAKFSQLLQDHPIFDESIDIRSFQHSFLHYYRWATALSEVSLFKALQTVMDYVQGEQMVLRHPNFPKRPSSAFTRFAQLTGVNVFKTNGKTSADYKNDQDPRVVKAKQEHAKDRERFLSELQEFFDNHKDELFSAQIQFLQKEIKNAQKAVEQKVSKEPTRRAKSNVPPKQSKQPQKQIPSAFDLYKRSKGTKYDHLPHDDREAKLLRHFKKLSDEQRQIYESIATSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVF7</accession>
    <name>A0A914GVF7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11151.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11151.t1"/>
        <property type="gene ID" value="Gr19_v10_g11151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F59C6.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765272" description="Glycosyltransferase family 92 protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11151.t1"/>
        </source>
    </evidence>
    <sequence length="480" mass="54422" checksum="B68806CAC295ADEC" modified="2023-02-22" version="1">MSFLPHLAPLLLLLQRLLLLQSSLTSQPLLLFFTRAFFYPRSSHINGLHSLHNVVIVLVTGDRRMAAFPSSNSDIICGTFTGLHQWKHLMATKIEPLHIGYEHAPCRLAIYRIICHSFPFQNAFQQRIGLRIGGSSPIEMDVTLADQTPRQLVVCPGRVFLFDQWHLLITSLELYRLHRIDLVLVHVHSVHPSLMALLRLYEEEGIVRVRPSLRMPSGDNSLAFDPNSETLWNNQLVNFHDCLYTFKESSDFIAFPDWDDLLITPASTPLPVELHNFVSVHPDSAALLPKRFPGHFPTIAQLSSDGREMADRLIREVRFSVWPSDAQFISKVLLRPKFVSGVDLHGPAGTIAWGHQSVELPVEKAFFIHARDYQRNPRITQRLPSAPSLISNLATFLTRHNASLSNLPKSERFLSTLNECLGRIEAKLMEKVAETSSDGLAWECVGADNRWSTPLNAGHFRFYVLEEEAMARFHGIRCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVP3</accession>
    <name>A0A914GVP3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11209.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11209.t1"/>
        <property type="gene ID" value="Gr19_v10_g11209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="284"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11209.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41332" checksum="2CE76CB0C5087202" modified="2023-02-22" version="1">MVIHRVVCAVSGGVDSALSALLLKRRGFDVVGVHMANWDPQDESGDSSSCPQTEDLADSEKLCDCLDIKLHVVNFVKQYWNEVFVNFLDNYSAGRTVVPDISYALATGHFAKTSQGDFLENNLPVGQKVQLFRAKDALKDQTYFLSSLSHCQLDRVMFPVGSLYKNEVRAMAFSEGLEFFANKKESTGICFIGRKRKFGEFLGKYIDSDSGPLIDIDTGKTISGIWHKGIHNFTIGKRLRMENCIGSLEKLSPHGDALYVAGIDRSSRSVYLCAGNFHPKLFSKRVLVSSPVWISDEPPKFHGPNRLQCLFQRTILPIPCALYSHQKDDRFLELEFGSPLRATAPGQICVFYNNDECLGSAQIERLLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWX0</accession>
    <name>A0A914GWX0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g1192.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1192.t1"/>
        <property type="gene ID" value="Gr19_v10_g1192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="379"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1192.t1"/>
        </source>
    </evidence>
    <sequence length="1529" mass="172158" checksum="0A06E77DD3AD1389" modified="2023-02-22" version="1">MHTNHGSAMKNKAGLATKRKNVQVVVRTRPLSEMERDERCKNVVSCDSVSKVVSLKTTGNEKNHGHRQFGVFDRVYGTESTQIQVYGDVVAPLMKEVLSGYNCTVFAYGQTGSGKTYTMEGRHDESGSYSWETDPTSGIIPRALHQIFTELSTDDIDFTVRVSYVELYNEQIYDLLSLSNTSQCESLRIFDDKSKGVSIVGAEEVIVRTRDEVYDLLRRGADKRRTAATMMNISSSRSHSVFTVSVMIREPGLINGEELLRQGKLNLVDLAGSENIGRSGATDKRAREAGNINASLLALGRVINALTTSAPHIPYRESKLTRILQDSLGGKTITTIIATLSPASSNFEESVNTLEYAQRAKNIKNNPEINQKITRRGLLKEYNEEIERLRRDLLAAREKHGIYLDRENYDNMVGEIEEKSAKVEDLEGQLAGQLQRVKTLLEDFAIMDENYQTVYNKCLAALDKLEKRKTEVEQLNKDLAQTKDNLNSANSALKVSENSFVRLRAQAYRLQTNCATFYKDLVGQREKRRLPIRRNIPRTNGKGKDRVNTANVSSNLVQSVSNIGKEVDNFNSLIDKTLNTFRIEAEKAQSKLQVFVSSCKEHMQGQLDQINHHSEIASDRLKTIDNIVAEQKDSTSSMLICLDTALYESQSTTEQFLNHDYKRFTATGVTPARRKTNSFMEDLVELPPSQELVRSQLQLCTPRRASFYRARDSILDSSDFFNTLVSPNTLKQNLQMTNLDEVDKLETIGENSERGADVEDGSVGVRQSVWANAKFPLIDKSVSKVLTNCESRKELFHCSFRPALGHLVALLLDSFGDDSDVNLRLKSGNLLCLLTNLDFAAESADFVAFVLPGVFSRCRQILINSLPNLRSLDLVRCACQLIINAICVSFSELGADCRPNFSSEEKAKPPMSMNVLSFRRDANWVETAARRILPQTSLLLSHLSSHSVDYIRYESLNILSQIREQISSECFGPQFDRLAIDIAVLLYRDHMHKTRKLARRLIEDVCRQKGDLFELHTLNLLKKAIKSFEKDVKNASDGGVYLDNFNNLVQIVGSTLLDRLFNLPEFVDKFLSPITRVIAVDHSKEMICDSYDRNPKGVSALPPMKYGLCAKQFSELASLIVGTRNSEKLFDWCFENFRINSSVEQRLSIAFFAYSLLDALKDGHQADHFVGDVLQMLASMDSVLEEEVLDHRIADAIVTNSAESSLIQLLLRCLSTFHSRADDMFSARLRVDVTYELLKWCSSSNFGVKNAAELALSRLAESHCHQNVSSLIQSDAQQIVFKLSMDSRDFAVCPRFPLVFAGMVSRCEAGPMLLPKVRSVVDELLLWLDRSDQKRTVVLAKALRAYLNALDEWFPSLAPQTVAELSKPDEEGRGVHFEQHFISSAHLPLLLKLRGRIVADDPSELAWPCPGKIVLAKAIEAVLCVCRLSKDFVYWKIVHEFMPRAETLLQILLKESQNLGKLYAQTATYKLQCAMLDSVPGIIEYAKISPQHFKSMEDIIAVYAQERKLPKKLRDRASATLDHIEKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXA5</accession>
    <name>A0A914GXA5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXA5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11612.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11612.t1"/>
        <property type="gene ID" value="Gr19_v10_g11612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11612.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11142" checksum="7018945D285DD423" modified="2023-02-22" version="1">MADAYGFLDRMTQRFTRGRRGKTPTTTNEDDSRLSEHKRKRNDAAGAGFGCVCITVCIIVVVIIVALGGFTLVMALMSTESFKDSPLEGLSKLLHGEKDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXF8</accession>
    <name>A0A914GXF8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXF8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11654.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11654.t2"/>
        <property type="gene ID" value="Gr19_v10_g11654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="199"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="437"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11654.t2"/>
        </source>
    </evidence>
    <sequence length="639" mass="70935" checksum="348426268A208F85" modified="2023-02-22" version="1">MSKKASKNCWKLRKMDYVELGDESSHAIPPEAPIFVNVRDHFAAWGKTLVRQFAKPANGPRRRVNVTLPPNPSNDQLNNCRGNGKSTLTHFPSTDPDQSQPDPGGLSTYGFEFGEISRIAFRPEYKIACEQANVLQPKHYDGNAFFNTTVTYRTDSTVFMPYDSLVELQLAPDRRKMDEGGTNSSLGRMKHLLDTGNGADVHFLVGGGDEKELMPAHKTILMAASDVFGAMFPFDARNAGTSEETKPVEVPDVEVGAFKAMLSFIYVDDVSGLNGDNAIAVLYAAKKYDLPELVVSCLNFPIWKLSNVFFAFGQTRFLGEGHIDVNADALILSEEFLEIDQKSLCEILDRDELMISEEIAIWNAALRWADEKCRQNGKEPTAANRRAMLGPALFKIRFPLILHEDFSDNIVSSGVLTEGELISVFLHYSRPDRARPEPYQLQFPTNGRAFTGLTIQNRWDSAACHDLALIGPNRLSVQITADNPMYRSVLAIRPIPKRKFGIFYYEVTLVAQKGFVSIGLAAKRMPLDKWVGWYKGTYAYSRWGDFWGHAVEECSHGRNGRPFIAGKPKFGEGDVIGCGVNLATRQIIYTQNGQRLGTAGLCVDSAADLFPCVSLYCSGDKIEANFGPNFKFNIAADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXP6</accession>
    <name>A0A914GXP6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXP6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11730.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11730.t1"/>
        <property type="gene ID" value="Gr19_v10_g11730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="184"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="300"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11730.t1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63910" checksum="AA400A4EB287D2D5" modified="2023-02-22" version="1">MYYCPPVFKTRMPVPAFSSKSPAHNRGLFENILVGREYKDLKIFSLTMSVKIECELLETDQQQQRFLQDELLLMGEDGNSAELLKPIAFCNGMSQQRQITEVHLQQQTLSATIVQNGMHGMPCSSTASSLLTSTPLTALVELDGAGISSGELHLHRPEGSDSSAGSNGTGSKAQPRQRRKVPEGELCAVCSDRATGYHYGVASCNGCKTFFRRTIVSEHSFVCQYNGNCDVTKNVRCACRHCRFAKCISVGMDARAIQNDRDRIGPTKRVRLSSGPDGKRSSMDEDQLSMSSLSPLTRFQDDKLVEHIMTIEDLCNVLRNCVLEEGKGVHETLAQPSLLYQARNMPKDVNTMYRELYPASMNDIQMWNIRELRLCLEWAKTFEEFQKMSLADQFTLVRHFAFTFNILNRVYYSLDYGPDKIVFQNGAYILRQPQESVKIPGCRPIYHRQMDEIMLPLRKLDISMKEFACFKTCLFFNPDVCDLSPDVRPEIGQERTKYLSALFHMIVERHGAAFGIQKYGNLLMMTPSIQNIIDQNDENMQVMEVFGHFWRINGFVKELCMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYR1</accession>
    <name>A0A914GYR1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">CPSF is a heterotetramer composed of four distinct subunits 160, 100, 70 and 30 kDa.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYR1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12362.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12362.t2"/>
        <property type="gene ID" value="Gr19_v10_g12362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000008">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="10">
        <location>
            <begin position="237"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="453"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="709"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12362.t2"/>
        </source>
    </evidence>
    <sequence length="888" mass="99499" checksum="C218971037F0C706" modified="2023-02-22" version="1">MFCWKRTGISNLTGRWAFVLSVAVYFLLDCGWDEQFDLAYIEAIKMRIPQINAVLISYGDIPHIGALPYLFKNGLNCPVYATVPVYKMGQLFLYDWINGHMNVEDFSLFNFDDIDLAFEKVQQVKYSQTILLKGDNGLQITPFPAGHHIGGAIWRITKMGDEEIVYAVDFNHKKERHLNGCTFDGIGRPNLLITDAFNALYTQPKQKQRDENLVSKLLATVRDGGDVMIIIDTAGRVLEIAHLLDQLWQNKEAGLMTYNLVMLSAVASSVIESAKSQVEWMSDKILRIFEAGRHNPFQFKHVKFCHTLTDLNRVRSPKVVLVSGLDMESGFSRELFLEWCTDTKNMVIVSENFSGRSGDRTLASKLIRIADSREKKRATNNMVTLGVKRRIKLEGTELEAYLTKKREKEQEAARIRLETVRRNARLENVESSDESDDEETLAAVVASVTAAGGKNGNLSNKNSGEVQRRGTVSGVGGVQRTTTGGGAVNTSNSYDIMRRFEQNQRISFFKQNKKQFPMFPYQEEKSRWDDYGEIIRPEEYIIADSAAAPQHLATVANEKDAVGEEGDVEEQRRVVVEEWPTKCISYITKIEILCKVEFIDFEGRSDGESIKKLLSQIKPKQLVIVHGTAAATRHLAQFCQEQQIVQGKIFTPTLGEVIDATIESHIFQVTLSDQLMSSLLFQTVKEAELSWLDARIIRKSAIVPVALDQATAEEREEGEGERRPSEEQQLNGGAMEGEAPVGGKSGGEGPEEADEQMESDETPAESGEETQGQSAVSGSRKSAIRVPDQLFLELLPSSAIPPHQSVFVNDPKLTDLKQLLTSNGFHAEFHSGVLYVNNVASVRRNEAGRFHVEGYACADYFKHKIARGSYDRKCLSVNCFGKKRRSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ73</accession>
    <name>A0A914GZ73_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ73"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12697.t3">
        <property type="protein sequence ID" value="Gr19_v10_g12697.t3"/>
        <property type="gene ID" value="Gr19_v10_g12697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="65"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="850"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="600"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="826"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12697.t3"/>
        </source>
    </evidence>
    <sequence length="1051" mass="119424" checksum="FFAD769934D480B9" modified="2023-02-22" version="1">MSISPESNLEPSVDQPAELEVHPVISPTSSCASFDLLDFDGDAAGTSDEPGKISEHEGGNGSTAGKVKDKLKEESKNNTKELGGKTFGQMEESFAKLELQNKELRAELEKRRLQMMREIDWISVLAEKPMSKNSYGIFYFEVKILEKKGNIVIGIAPKQMLLDTFVGYRNGTYGYDSWGILLGHEAEGSSHRANGRPYIDGKPKFGCGNVVGCGVNLKNGQIIYTKNGKRLDTANLFVFFAANLFPCVTLSGSGTKIEANFGPNFKFNISDESLEMDRRKSGNRTFGPLRLGPTFWATPFGPRRARVEVGAFKTMLSFIYVDDLSGLDGDNAIYVLYAAINMTWPDWSKRAWTFPDRICAMFLSHLTGHAFLKKRTLLGTLSPHKEAFSEKIVPFGVLTDAELVSVYLHHCHPDRALPELYQLQFSTKRRAATKSPGDEIKLKIRRSINGNGAERMDFRRCYALKMEFGNSTDPVNFIICLLCCFDEIVPFKLQNNLGERLMTRCSGKGKWLLVRCPIERDEDKWAKWEQEAANCCQGNSVDIYFGDRGTNDGPFSEEVRVLRAKIAQLERQQTINSPTSSSGGFNLAPQNAKRRRIEEVEEHEELVGRMREQMEEWKRITKLELENKALRTELEHQKLLIAHNALQTKLEQHQNKQQQSREDHEKLLNAQKNLMEEMKEQRKMDTLRQQQRQKETNDKIDWLNEDQQKLVSIDQFSRVQTTISDLEHKQKDDQEEFLRKMIESLKSVQAMVVADLGRLNMELQSDQKALLERLNGLEQKQTANSEQQKALIATIDQQCNEREEKLNNILGQMLQKQMNELGNCWKKELEKGMNQLKEELSSKMEQYQNKQQQNIDAFTEAQNGNGLIPQQNRWDSTACHDELKLTEPDRLIVQYTGENLTWRSIFAERPISKNNFGIFYYEVWILAKESAIHIGLGSKQMPLGTPVGWCKGTYAYGSHGYFLGHAVDGCRGRFFGGRPYIERKPKFGGGAIIGCGVDLATRQIIYTKNGQRLKTTGLLAPFAGELFPCVSLCYPGDKIEANFGPDFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZM5</accession>
    <name>A0A914GZM5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZM5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12824.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12824.t1"/>
        <property type="gene ID" value="Gr19_v10_g12824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="103"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12824.t1"/>
        </source>
    </evidence>
    <sequence length="549" mass="60912" checksum="B602C688FCC664EA" modified="2023-02-22" version="1">MRSPVDKMSSCRRSFVSRGWQCVSPLFSVVFCRFGMTPFSPPKNSPHSPLLAHQQQQPPSTSTTRTASEASNIGGDGGESDKIMAKQTERNNSMELEERENGISTHLTLINFMKGMIGSGILTLPIVFKQAGLWTAFGLVFLFGALNTVTMHMLVRSAHHLARTKREADGEPMSYGEVMHESLAGSFPWARPYAKTSKLFVNATIVVLQMGIGVLKYDFIVAHLRELFDEFTSFHVSAFVWALLIFAPMVLLNFIRTLRRIALLSSIGNVFMFGAYGIIFYHLLQPPYRIANLPWWNTPAGILSACGSILYCFEGQAMVLPMENKMRFPAEMVSPFGVLSTGMALTAIFDAAVGFLGYAKFGEHIQGSVTLNLAPTPLLILVRLIFTGISFLDFVLQQYVTIQMLWPSLRSRICCHDEDGEDSNRNNSTTAATTPPLLFVNLCEYLFRAILVATTMLIAIGVPNLEQIMPLVGFSGGVFLAFVFPPLIDTFTFVPSLMDSQQRVKLCKRLARNACFIAIGLFGTGKIILTNEDRTTLDRIFKFQADHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0Q9</accession>
    <name>A0A914H0Q9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0Q9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12167.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12167.t1"/>
        <property type="gene ID" value="Gr19_v10_g12167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12167.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26702" checksum="0BF8A5E7240DA2EA" modified="2023-02-22" version="1">MVPRSVIALQQSHAPNCDPNSWMKRSFYIIETNGVPKEVYCTDLMHRARQRRRLADGHQLPRVVDKWREEWTQGVQVPLGSTKEIFTFENTALFPELANNKLECFQLPSKLISRDKSTNGRKRQRTDQSGEECNQILQRKLSTQFEELRRLRLNSEKVRSLCYLVTKREKLKKLSLEQFEQQVKQTADKTFGLVTAMSSRRWEQLLSEWREAINFNVKSGAETRNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2A2</accession>
    <name>A0A914H2A2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2A2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1334.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1334.t1"/>
        <property type="gene ID" value="Gr19_v10_g1334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1334.t1"/>
        </source>
    </evidence>
    <sequence length="446" mass="50785" checksum="2A5DE03F8D5731F8" modified="2023-02-22" version="1">MNILIVQIEVTEIKEINAQPMSGAESAECVRWGDKEGRAVVMAPKSVASSANEHPETTAHPKSTDKKHADQHPENTILNEHAEQNASSNEPSTSKSMHEHFVEPPEDASSTNKSAIQYVVEQTAFSDELSISKPDHVVEQPETMRKRQIIVNTYELLNEQAAIIVALTDNESVQLQMGPINDYFMKFKQFVYALPDNSTFKIERLLRISKKIEERKEEVKFEEDKAMLEKIREGMNGLETELRDKIATIAEEIEVIGGVVQKVIEYQVGKYVQKEYNYLLTARKNLSLPLKIISEFFGKLELSEAYLKHVEKTIRQIYLSVWTSRRYYVKVESCLVVIGAMISNVSDEVAKNLQIEKVLGRNPVEHLFELQQVAQLEGMPLTEEQVVLLYMSKCLQRAQTLLEKAIKHLKSIENDFCLINSVGIVIKSADALAKLRRNILLMKNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2J5</accession>
    <name>A0A914H2J5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2J5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13406.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13406.t1"/>
        <property type="gene ID" value="Gr19_v10_g13406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13406.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19326" checksum="86A5B25144CA2EF7" modified="2023-02-22" version="1">MENGHKSGQTGQFDRSELDKRSNSIDQSLTNGAIRSIRVGQTEQFDRSELDKRGNSIDQSWTNGAIRSIRVGQTGQFDRSELDKRSNSIDQSWTNGAIRSIRVGQTEQFDRSELDKRRNSIDQSLTNGAIRSIRVGQTGQFDRSELDKRSNSIDQSLNRTVRWMGVGYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2N3</accession>
    <name>A0A914H2N3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2N3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12677.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12677.t1"/>
        <property type="gene ID" value="Gr19_v10_g12677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036972418" evidence="2">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12677.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33129" checksum="CAA08647EBCB3731" modified="2023-02-22" version="1">MPTFLFLAAVCLLVADASPPPKTNTKLEKGPASAGNAESTPGLPPQNRWDTDAHHKDLTLTDGLIVQNNGKDKEWRYVFAKQSIPKDGIFYYEVKILEKGTRVQIGLATKQMPLDKPVGWSEGTYAYASAGYFWGHKDSKCTIGTANGRPYIKGPWFGNGDVIGCGVDFANRQIFYTKNGQRLITTELHVDSAAKLYPWGYYHWYYKICRATKLDVSYDKVQEVYDGMWVNYNLNDAACDDWARDFFHRVDKKSKEEEAAERGRLYIDQGIAAVFRLFAVPYLKVLRGVNELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H371</accession>
    <name>A0A914H371_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H371"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13573.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13573.t1"/>
        <property type="gene ID" value="Gr19_v10_g13573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050998">
        <property type="term" value="F:nitric-oxide synthase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF17">
        <property type="entry name" value="CAPON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13573.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="15048" checksum="02512EF7D9AC4855" modified="2023-02-22" version="1">MRRVRYEFKARNIKKRAVDIVVSVDGVKVVLQRRKKRQKYMDESKMLVMSHPMYRIYYVAHDLYDPQIFSYVARDGASNSFKCNVFKCVEKVNHYPEMDKLYEKMEIETLLPVVLVLWDGKCALMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3X6</accession>
    <name>A0A914H3X6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3X6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13619.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13619.t1"/>
        <property type="gene ID" value="Gr19_v10_g13619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037723680" evidence="2">
        <location>
            <begin position="24"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13619.t1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44943" checksum="BFC25086C663D30C" modified="2023-02-22" version="1">MNEFWILILVAFFATNLLNKAEAVKLELKTFDEIFGEGCWDKGEAEDLKTPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSIDQNPPLTESDHSGQIEPNSTDQNPPPLTETDHFGQIEPNSTDQNPPPLTETDHFGQIEPNSTDQNPPPLTESDHSDNAKNGEEQPEMSSNENIAENERKRKIVAKFHGMREEFKQKGKYSRKEWVQIEQKIAKNFNLGLSLATIGNWKRKFGQTAPNKHSHNKQEELMKRYYQIKDKNPTIRNVDIAKMLKIGKVTLYKWKKQFQPNFVDSVEENAAANVQEIGKTNSGTISLRSDVQFWSFKISPYIYICGGCICVLHLAVRASLLGLLAKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H419</accession>
    <name>A0A914H419_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H419"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13950.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13950.t1"/>
        <property type="gene ID" value="Gr19_v10_g13950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13950.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21527" checksum="4EF4B0868AE8AAA8" modified="2023-02-22" version="1">MNSSESENPISPAKGQRDNEKRKGGTAGTKRSSFSSSRHTSSLPPAAPTPQPLTELLFASSTQILPAQWLVFVLAQPSVSLQFWVCVSKKPRPSPKKRPAPMAQSSDCPDKTKKAKLDDASTPAEPFPNGGFDFINDGFDQFANGGFPREELSPTFCNWAFGELAPTKCIFCIAKDEEEGKEVEEEEEEEEDEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5Y4</accession>
    <name>A0A914H5Y4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5Y4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13523.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13523.t1"/>
        <property type="gene ID" value="Gr19_v10_g13523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="123"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13523.t1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41408" checksum="4B9C8DFAF663BAE6" modified="2023-02-22" version="1">MNSDQNVSSIIIQTLGFCASAAVATFVVSKVLQRMTDPNYEGKENAKKRMAQIMKVLKLDSNKFSLNSYELRIATLISLPEEGADIEEIGGCSATLHRLQENVILPLRLLASKIIVPSSLYMPPKGILLYGPTGCGKTMIARSIAKKVDALFVNFDISILDDMLYGETAKLTKALFTLTAKIQPCVIFIDEIDSVLRSRQHRDQEGTAIMKTQFMLLWDGFLKSDSTVIIIGATNRPQDVDEAIMRRLPLRLHVPKPDLVAREQILRVLLRKESLVNNFNFKKVAQEMEALSGSEVKEVVRVACLKRYQDVAQSLVNLPPELRSAVGMGRSFDEVKLSHDDVIRAFHDYRNFTMDTFAGASVVTEEVIAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H730</accession>
    <name>A0A914H730_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H730"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14428.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14428.t1"/>
        <property type="gene ID" value="Gr19_v10_g14428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14428.t1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41576" checksum="43F02FC70854BA7B" modified="2023-02-22" version="1">MYLLVIDSYSKWPEVFEMKSTGSAATIDKLRYLCSRYGLPETLVTDNGTQFTSKEFKEFTTQNGITHLFSAPYHPMSNGQAERFVDTFKRTCRKLKGEEVVNRLDTFLTTYRITPNDSLPEGKSPAEMFLQRKFRTTFDLLRPKRRPIVVRDEEMEKRFNRRHGAKPRSFDVDAKVFARHRLSQPWRAGHIVSRKGVMYEVRFQDGRLGRFHANQLWDRTADDKEEDPLDVFNDAFGLAVREERYLNWRNVYHFPPMIIDQLTAHKMASLSPILAHFIPFHIFVCTQLDPINIPIFVRSIISSPNKYSLQFGLWVVTAGTLCQVESHHRASKTVYCKGCKIQDEEKSIANTGQHLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7A2</accession>
    <name>A0A914H7A2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7A2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1486.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1486.t1"/>
        <property type="gene ID" value="Gr19_v10_g1486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1486.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11765" checksum="52F4ECF312A8DACB" modified="2023-02-22" version="1">MRLLGQWALVCAEFLSKTSRLKQRVPCRIAMRTPRGVIPSRFASCDAGLASPEKCAKKAGCFALLKSFEIFSMARNLKIAGCFCARVVTFGVCALRQNVVQTKSSGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7D0</accession>
    <name>A0A914H7D0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7D0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14389.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14389.t1"/>
        <property type="gene ID" value="Gr19_v10_g14389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037264748" evidence="2">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14389.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23275" checksum="B930B990281FEF8B" modified="2023-02-22" version="1">MLFENFIFVFIKLLFFAKIGQVSCCQGAVYADRYCKAMWSLRKHCPKPFKLPNCNIFGHNCVVCTYDYNKTNECCPRIYCSCYYCCDKQYAEDCPDGCSECVKEGQGGCPENSAAVNFKSNGNSSSSMLEAEAKAWEHFDMIDVDKNGSISLNEAIDHLETKLKNGTSDKNLAKNVSWFAVMDSNGNNQIEPGEFDRSLIGVNNRTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7H0</accession>
    <name>A0A914H7H0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7H0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14725.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14725.t1"/>
        <property type="gene ID" value="Gr19_v10_g14725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036926302" evidence="2">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14725.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14312" checksum="E2B790ED35561434" modified="2023-02-22" version="1">MHTKEAVIVLLLVLALCRCCVGGPKRSSKDKGTPSSSTGNLFPAELAKAYNEIANNKQQQQQPVDNDKLPTPGNPGYAGVQGVQSVTLTDASGKSVTFTKVEQQQQQEAFQSLALNRAALNRAALNRPALNRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7X1</accession>
    <name>A0A914H7X1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7X1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1485.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1485.t1"/>
        <property type="gene ID" value="Gr19_v10_g1485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1485.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17861" checksum="AE628DB347EFA9EF" modified="2023-02-22" version="1">MVLAHFGCISLKVAFRSQGPCRTVPKPCSRARPCSTAPKPCPSRARSVTVPDNSINQGREPDADHQLGFLGRSGRTEFYVTRFFQVCCSFYVTDSTSPQSGTSGAIKAGTASPRSTNRQEVFNNEVKQYNEGKTLESQVQAVQRVSKLSNIKLKQFNEQENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7X4</accession>
    <name>A0A914H7X4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Trehalase</fullName>
            <ecNumber evidence="3 7">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3 7"/>
    <dbReference type="AlphaFoldDB" id="A0A914H7X4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14553.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14553.t1"/>
        <property type="gene ID" value="Gr19_v10_g14553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="738"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14553.t1"/>
        </source>
    </evidence>
    <sequence length="1041" mass="119529" checksum="B9BAF1C2D3A6373B" modified="2023-02-22" version="1">MPWFPPFPPFIRWHLFIFFILGILPLLSPVVSVTLYLKKHFGENEHTVKDWGKMDCSLNGIDLTALGLERSCEEWPGLAPIYCDGKIIEAVNYWGERMLFLRDSKHFVDRPLKKEAKKIVDDFKTLFNVTEWKNFVVSDMSPAQVDQLSKFVRENFGMADEAPIPQPGALIPHVPEDWDESPKPFKTIKDEKLRKWAKQLNQMWKEMSKKMPKDMNGKGTQKNSLIYVSNPFMVPGGRFREFRYWDAYLIARGLIASGMTASVKNMCKNLAEMVNRFGFVPSGGRIYYNKRSQPPFLTLMVYDYFGATGDTEFLKKILPSLEKELDFWRTKRSIAVDVKGQNKTFYQYRADTNMPRPEAFCQDVDLVKNISDPKEKAKVWHNIASASESGWDFSSRWIKKDETDKENPWKLTNLMTTKIVPVDLNALICGNLEMLGHLYLKIGDKTKSMEYHRKYQLFLDDFQSLFYKKEHGIWYDYNLESGRLNEMFYGSAAMPLFTRCYHTDDLGTAERMFRRMEQFDKDNKMLSHPFGVPASTVTSAQQWDFPNVWPPLQHMLIEGLRRSSNSRMEDKAKELAQKWVSANFKLYQQNSHGCGEKMWEKMTAAGGIPGTGGEYSVQIGFGWTVGAVLDLLVTYGAELTTKSVAEVKCDNKIMEAEPLEFPNELTEYRWQRLTEAQKKVDEINKSQKHWTAVVYEPFALMTNAEFKQLFGAKLTLTNGPQNRHQLSWKAAEQDYKDLPQAFDARQKWPECADIIGSVPDQGKCSSCWAVSAAATLTDRVCIERLKKGQKTDSNDPKAYISAQFTLEATPESPGCEAGSNPGYAWNYYQNMTVSGTNYEMYAGCKPYTIGPIAERKWWYFVRPVGALNDDASWKMREPNCEKKCRTQYLKSHFSAGQEPYKAFKDEALSMPTVIDPVVWASSSGSGEERVAFKTYELEMMREIMANGSIQASYEVYDDFKATFDKGENQIYSHSPNSKTTNEGHAVKLIGWGELDAIKYWIVINSWGRGWGDHGIFKMRRGTDESAIESRGVYFGTVKFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8P0</accession>
    <name>A0A914H8P0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8P0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14774.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14774.t1"/>
        <property type="gene ID" value="Gr19_v10_g14774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14774.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9980" checksum="DA7EF70F3DBD2F7B" modified="2023-02-22" version="1">MFFRPIRPQYDQRIFHALFGNNSLGHKLMAIIHKMEKTRANDQSNLMCRRTDVGYPEHHDWAPARSVPARLAAEANQTKALSMLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9N3</accession>
    <name>A0A914H9N3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9N3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15077.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15077.t2"/>
        <property type="gene ID" value="Gr19_v10_g15077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15077.t2"/>
        </source>
    </evidence>
    <sequence length="243" mass="27542" checksum="0DF26E9F490DFF1C" modified="2023-02-22" version="1">MAIYKWKRELGQTEPNKYPHSEQNELMKCYYEIKGKNPKMSVRSLGPSIDHTSIASLATIGQPSGATKLGDADPLGDQNEIKEKMKMEQELKNTKEFEKRVAKLELENKALRAEMEHQKLLNAHKDLTAEMNQLNVNIIDALTEAQKGNALTPQNGWDPAARHEDLTLSEPKRLIAQFIGKNRGDRSVFAKCQFRKRISAFFLATCQTIYSINGKRLDTANLFVSFAAELFHAFRCQTLATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9Z4</accession>
    <name>A0A914H9Z4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BK channel</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H9Z4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15162.t4">
        <property type="protein sequence ID" value="Gr19_v10_g15162.t4"/>
        <property type="gene ID" value="Gr19_v10_g15162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="12">
        <location>
            <begin position="261"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Ca2+-activated K+ channel Slowpoke-like C-terminal" evidence="11">
        <location>
            <begin position="488"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15162.t4"/>
        </source>
    </evidence>
    <sequence length="637" mass="70356" checksum="39D52A0431EA29B3" modified="2023-02-22" version="1">MPPSLSLRNVHRDDESRVRRNALQRRGRVSTRAEFSKHTPDWLSFYLCGAGMEFCYSLFYCGMYTETLSHSFVGMRFPDAAQLLFTRLGLLLLAIELKDDEKKECNIAINPGPSTVIQSQTQGFFIAQSADEVKRAFYWCKICHADVYDVSLIKKCKCKNLSLFRKGGKAMMKRASTAAGVISAGAQRVNNGFIGRSDPDTLNAGAGQQLINVDTGRVGGGVDLFEQQEMKYDSTGMFHWCPARLLEECILDRNQAAMTVLNGHVVLCLFADKDSPLIGLRNFIMPLRASNFHYHELKHIVIVGDVEYLKHEWKTLHNLPKISILNGNPLSRADLRAVNINLCIMCVVVSARIPNPNEDPTLADKEAILASLNIKAMEFEDTLSGIGVPVHRVVQGIPQQQQQSGTRSGGGRQQQQFWQRPPLGVLIGTNVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRGGYSTPDTLANRDRCRIAQITLSDQPYEGITTGSTYGEMFSIALKKHGQLCIGLYRLHDQASLDSNKRYVITNPPAELRLLISDNVYVLEQFDFGYSKFETFGSETGGGGGGTSVGSDRLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBD5</accession>
    <name>A0A914HBD5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBD5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15032.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15032.t1"/>
        <property type="gene ID" value="Gr19_v10_g15032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037248649" evidence="2">
        <location>
            <begin position="24"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15032.t1"/>
        </source>
    </evidence>
    <sequence length="455" mass="52769" checksum="FE9D824C90453653" modified="2023-02-22" version="1">MEEFWILIFVSLFATNSLDKSESVQLEELPLQTFDELFVDEWWDKDEAEDLKTPPPTNFGQNVHHQIGRQNTQSGQIEPNSTDQNPLLTESDHSRQIEPNSTDQNPLLTESDHSRQIEPNSTDQNPLLTESDHSRQIEHNSTDHNPLLTESDHSRQIEHNSTDQNPLLTKSDRYGQIEPNSIDQNPLLTESDHSRQIEPNLTDQNPLLTESDHSRQIEPNSTDQNPLLTESDHSRQIEPNSTDQNPPLTESDHTGQIESNVEDDRKHKTVAKELGLSFRTIYVWKRELGQTAANKYDHDKQKKLLMKRYYEIKDKNPKIRNADIAKMLKIGTNTLYIWKKQFDRQHFHPNSVEENTAANIAIKLGLSFTTIYDWKRELGQTKPQLKHSHSEQKEMMKVYYEIKDQNPKIRDVDIAKKLKIGTDTLCRWKKQFKRPQFHPNSVDGHSVEENAAANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE00</accession>
    <name>A0A914HE00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g16630.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16630.t1"/>
        <property type="gene ID" value="Gr19_v10_g16630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052823">
        <property type="entry name" value="SXP/RAL-2_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593:SF36">
        <property type="entry name" value="DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037173299" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="630"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="951"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16630.t1"/>
        </source>
    </evidence>
    <sequence length="1459" mass="157881" checksum="B721EDD6158C6881" modified="2023-02-22" version="1">MPILKPLKLLLLLLLHQRIGAQPDDDIDNTEELEMFTNRPPRARLFVDKTSASTTLPTSSPMPSSPSPSLTTTATETLAQIMRANPLLATLSMFSADSSSVLLGKSVNTPIGLKSATNQGVSVDTSISPYRKPTTNVSSIHHKSIRPTVTAVKGRAIGQTITTTLSPPALPSKPNTHQMDNFDAIYQIFNVTMFDLAEKEPDVNPASLPLAVRAQERRRAEASKKALARQLEGKFHHRSNRLESEEAADDRQEAKQPQEEAIGVEEEEEGTTMPFEVTEALTIALASTATDGPSTTMPTTTAAAMRTGTAPALLGQEQFPMDELRQRLKYPWERERGEQLQQHNMTTSPSPSSVSSSTSPSFSSSSTTSVPSSSSSTVLPLPSVVPGASFYVDQHVSHGSFGREQSDATPDLVYDPNVLQSRYGYSGLLSPEGDRLVRGQRWPPRQRGATYTYHWPIFPPPGKFFVLKMRQFSNFESSSIVPAAAVFFIPPSPRLSVARAVAPRVHGHSTLIDQSPEGTGKKQTLGYWPSKSGQEEQPLATTTANTAPSTDSGGGSGLAPVAGNHLRWVPAQVAAANAVPISSSSTSSSTSNHQDHLRSDSGRRWLCQADPAELVLTDSPPVVGQPMAVCFRRVRQCALRWAPPLLDRRVGLSRADCVRFCVGHSECAALTFARPSSTCDIFHTRNGTGTAQLHHQRDFDYFESKVGHGKALSDCWEDFSSNDDGGPGDEPNTSTTVIDSGEELGGQDTLYYNNRTTVPYPSSSTASTSTVADTSSASAAAAAVTTAPRESCSADRDLVVFKSKGYQLATPAGMRRQNVGEPPPGKMLTQQSTETECTFSCLVNVAKGKTPFECLAATFDTVTGKCVLHGIGSLAEGSIHLVPDQSFSHYEKGCILSDIVELCRGNPIVRFPQKSLLGFAVGSRHATSLIDCLELCLAHNNLNNHHHHPHLSSAASSSSSSSSAGTRSGGSNAGRCRSVAFFYEESGGGGDGHNCMLNSESRHSAPAFFVDETEALVDYASFDECYELGDGTELAELGRSREHDEQHIGEVQQMMTVTQAAAVAIDRKKNVPKLHKLRPLSEQRLREGGEPNGWQQQQSEQQLVLNSDQMGQFGDLSGRRQNAIVVNRQPTKNAPRAQAPGKQIVAELSAVYAVEDEATNGRRNGSIAAGAAAGGRRTMREEEATTPPKAMLGTGPHGLEMIIGQHVDGLETDGPTNRRVIKIDIFGTFSHIFGTFSHIFGTFNFIDTFDMFVPMCGTLDGLFFDMFCHDFDTFKPLFAIVLSLFAAAHLLERSVRDINYGNNGTGVYNDDASVQQQQSQQQQQGAGISIASFLGNLSPSTRVQLSAIANSPNMTKEQTNEALDELAQRQGQPFYTVYLGLKSAYESARQQLDQQHAALMQNQSQAVQEADAKLQTIVNNQFITPTEEQQQMADQMAQFPSVVQQALVELAPYPSSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE57</accession>
    <name>A0A914HE57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE57"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16189.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16189.t1"/>
        <property type="gene ID" value="Gr19_v10_g16189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037115250" evidence="1">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16189.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31309" checksum="24B05BDA16B09EA4" modified="2023-02-22" version="1">MLAWLSLVVLFIVQPANVLLWTTVPPSPNIYSSGKVAERPADTLLLVSTIDGYMNAIDAHTGAHKWRFHEGPLLSSPVSIQRGFTFIPDPRDGQLYLVVEGRLSKLPFTIPRLVQLSPCRSSDGIFYAGSKKDMWISIDPETGDRSNTFSAVPFSSPQSVCPADRPNAVHIGKTEYHIQMMDTKRRGRHWNATFVDYSSYLLPEDAKYPLKHYTNSVDGRVLTVDAQTGTVLWQKDFGAVIVNMYLLKGDGMHKLPSTAIGQETFNTFAQVGGQAGEGQHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE69</accession>
    <name>A0A914HE69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16316.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16316.t1"/>
        <property type="gene ID" value="Gr19_v10_g16316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16316.t1"/>
        </source>
    </evidence>
    <sequence length="868" mass="95462" checksum="A54B6E72F0025CF7" modified="2023-02-22" version="1">MFHIIDRRIRSASSKFERLENSAEMVLARAQQSAVRSLSLRTRSRSKKNGGGGGGGGEGTEVEGREASEEGEGRRPSRTLLGLLSPRSTPNRPKQQQEVEQNEHKPMEEDRAEMDYVEVQNTDTLEGIAAAHDCTVGGLVKLNKLTSRMVFPGQKLLVPIPSMDGDTNNNSNVKNDKNGKINNKFNYNNVETIYKGPGHAVRTTSAVEKCSIQQQTNPESAQNIMSTDSFSKQIRRQSNAELGRMASELDPEDEESLQRFLKIRVKQVTESDGTILGTLLVTPNCLMFDPDPDHPLVCENGSDIYGMVANMEDIVSVTVYKNISSLTGEQPNKAKDIFDPKNVMRATQIENAMDGANTSNQITGNSEKKASSEKRLHSDAKLVPKSSCCKEGQLIGMDEGHLLIYGTSAGGLLLGHLPDERKAIVLGSVSAGSSPSNSEQQLPCIDEESEVQRAKRIEQTRENAGSAGIVENRRTVSDMYCHQKSTMLEGIGDLKDSSSSSPLLQSDQFKWLKNTTQQSNSLDMQPLAETEECKRAHSSFDQALSLEMGKHRLKSGEQNNQQRRSPSPSSPFSRYSPGMARKSFDKLGRTLSAKATSFKGTVQSGAQSVAHEVVTHTLSAADHIQSGFQNGAKMVASVPGSIMNVSTELLQEGQNGVKEVVDQLKALGESGEQSDRSPLAIKREKSLATLETLCQRTQQAREESVQRAHDTGFVLGAEETPVVLSDCGKNDESRPIGTPPEPPFYMVVRVDRRKKQKQRSVLLQKTNSAAEIVSLTDSNPVTALSSTSAADLLQEEASAFGNKRKREFCGHRKNTGRKRRARPKKPTNSASWRSWRRVRKCPNWPELVQAPKNTWEVSSYSRETSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE70</accession>
    <name>A0A914HE70_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE70"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16530.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16530.t1"/>
        <property type="gene ID" value="Gr19_v10_g16530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037194765" evidence="2">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16530.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="16554" checksum="7F648FD39C651F29" modified="2023-02-22" version="1">MKLFVLLLLIAVLAVLAGAQINNDGDGDGDDNNLDPDPEEVPTQDDVTGPSDKALNDTDTASTGPTSTLKNSNENATTQSTPDEDETSPSSKLPMNPSTTTTDKGEKTTIYASIFFGRAAVINMNSTAFGTAPPMPTTIVACACARLLLLLLPVIGDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE96</accession>
    <name>A0A914HE96_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">H15 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HE96"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1634.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1634.t1"/>
        <property type="gene ID" value="Gr19_v10_g1634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1634.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="23561" checksum="3FBE2B54576A3A79" modified="2023-02-22" version="1">MTAAVTGSPQTQSQQEGQSPKVKVSKLKKTHAPASHPPYIQMIKKALGELKEKKGASKGAILKFIVSNFDVGGNQMRANAQLKQALKRGVSSGDLKQVKGVGASGSFKLGDETVPKPTATIAKKIIPKKTKSSPVKAKAVVKKAAKKPTPKKSPKKAAVKKSPAKTKPPVKKTAPKPVVAPAPVAAVAKSASPAAKTPTKKGVKPPAKKVAAKKSAKKLGGGKKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEA0</accession>
    <name>A0A914HEA0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/potassium-transporting ATPase subunit beta-1-interacting protein</fullName>
            <shortName evidence="7">Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein</shortName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NKAIN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEA0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16215.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16215.t1"/>
        <property type="gene ID" value="Gr19_v10_g16215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008516">
        <property type="entry name" value="Na/K-Atpase_Interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084:SF6">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084">
        <property type="entry name" value="T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05640">
        <property type="entry name" value="NKAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037414574" description="Sodium/potassium-transporting ATPase subunit beta-1-interacting protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="508"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="584"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16215.t1"/>
        </source>
    </evidence>
    <sequence length="836" mass="90783" checksum="34068D1FC2E837FE" modified="2023-02-22" version="1">MLRLILLLIILLVMFTDIDSRLDPYTKTRVLGVATNSLTHPKPHSLRAEEIANVWIEEAVVEEDGRQTLLPHHPHPIQRHPSIHPSIDLQPSWMTRRLRFCALIWLVLWLAFSTVRQVFDLVGKLWALVLIDMVQLLAIVSGLFALCQANSMPCRNRLLTTLTLFSALSVAHNVALLLWFCTDLLVADHRQSDLLSFGLPFGHSFFLRHTPLCQAQFNLSAQRWEQQQSHCPIPYSHLEGGQAVLHTLMALGTLLLVVTILLGNRRRHGTRAERPVCKLGFAEERITAGGCAVSASTNELSSSYMDPSCFEEAFTAQAMGPRQFASGQIMPLPPAPPMVGIVRRSYPRAGRRPAAGSGECQQRSRRSNLQKKSAHHRQAAASTPIVPVPPVLHERYSSLSTAGATDVGGGPTNQRAVSNSNNNTASSSSTSSAYGGDNTIASSGSSNSRGYHHHQQALLPKGRQSFYAGVGPPGRIRSPCYSRTTTAQQKNFGQVDGSVQQQYQQRQYRRGGSMRTFCVPEPNDAERAAGSTISHRTFSPPTSSPQSTSSYYGLPRGAGGNASSNNMTSLISFDPKSNTLIRVREHRRSSSSDEADENGSGVHESFREADVDEQQQDGHENTNNKSVPSSPAPDLPPSCPPARSEELLHPHLVVPQQQRKNWCNSPGPLRQRVPSMAGGVGSVMFNSAASMGQANFSSGNGGQMPGYNSQRPSNAPNNGYGTYGTQQIDLNTNNICHNDKTSTSSATAAIASTASIYEAYVGAAVPLDAHTAFPALIGQPPRRSLVDCSAASIIRLSQSDLRSPAIIRSSADECSNNKQTKLRPPGTNETMLGMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFP6</accession>
    <name>A0A914HFP6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFP6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17095.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17095.t1"/>
        <property type="gene ID" value="Gr19_v10_g17095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17095.t1"/>
        </source>
    </evidence>
    <sequence length="966" mass="106749" checksum="56D4EC6D029E1295" modified="2023-02-22" version="1">MISERPTFSLPSHNGHQPNHTFNGTNIMAENDQESGNTTTTPTRSSNSAGGSAENNVTTEQKRMFRFLHSALAIVSILWATVCLLIYFHAPSSQSQQLFDCRWHLAAILVQASFGHVFVFCSRSALLFCASFLSTQYAIVYSLLTLVIYSLDTALLMLFPRPPGVGMDFGPYLKLTAVFIVLSAFGLGLSLAHMRKLLQTGKALAKHGETTTTFTTFAGLNNQRTLRALTGCQAGLSLLSIYVAASLTPMKFWYVRTHIVQEFSCSLLATSLAVMQFLVFRLANGGGPLLIKGIVLANACQIVQELNMALSAFYTFFYVGRIYDAVEERTSFFTGQESVHVQLALARVQHTKTVLALSLLFHIGRMLLNAFVLLSLAPRVFDTALTFRVKFKLDSEMVQSDQQWTQTRKRESKWLYSVSACVLAVAAGHVLLNFGYIWESMIFESLSVATGLSFVFSICLLGAVGFYAFRLLRFCLILSAYISLNLLVTAALLLFAFIQDFFFLATTLDDDKDTIMTTLNTSSSLFRGSVGDRNDSLTMDDSDANGGDSTLKILLYLADFALSVGTFFIAAFTLRYAVSTLVKTKLLQTQPAGVQRAVRLLRALSIVGIVSAAIEFLLLAELRIGKTATMSHLSVNSSFYDWLLTSAQFVFLFYVTRFERYQALLPVQILQLASVAITTLDLIGQQTDIVQIYVNSVLQFYRVTEALFRRPVLSEGSASAVFVTHTSSLAIPLHLFVDILALHFLQIAQWFLTICALGIALYCADNMVADESESSNDFHELRNSGGAQIQAEQRNEESPPPPCPTSSTPPPMLKMVQSNGNGNVQQQRHFNNAAFENQLYNMEELESNISVDFEGKKAPEAIAQEKHNGRPGHRFAASIESSPYKDINLNRLPDILSNFGLPDILSNFGLPDILSNFALPDILSNFGLPDILSNFGLPDISSVGPFGWHRRAVLPEHIKWTGNGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFU5</accession>
    <name>A0A914HFU5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFU5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16576.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16576.t1"/>
        <property type="gene ID" value="Gr19_v10_g16576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502176" evidence="1">
        <location>
            <begin position="20"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16576.t1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39480" checksum="630460EDB275E396" modified="2023-02-22" version="1">MAFALLPLFVVTFIQFGHSRMPVPNEFELNPPKIELLLRRTALMALLRAKANAMLETVPLVDKVLFRQCVIESNALSPVKLAKCLAKLIQLRDQLQRQNEWEEKLVESSSDAAPEGKEGRNDFFQSSLITKRKLARIRHFFALWRRWKGRRLAELKMKNRRITLGLGGATDKRKPDEVEAVRHKAVRRDTVRRNTATLLLNDDNLRNLQELERYTRVFDKARRSIAQINAHNTELISRFDPSARVRSAMPDGPPALLDLQHQIERFFNSLGIDKISLLSPRFFSLFPSSQRRRPNLLSPDLFSFHNNSASPLSIPSLLSSVHLSERESAAWLELLMNITGSARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG83</accession>
    <name>A0A914HG83_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG83"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16672.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16672.t1"/>
        <property type="gene ID" value="Gr19_v10_g16672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16672.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8279" checksum="A6CD4B05C59F50F9" modified="2023-02-22" version="1">MMNKEGRDAEDSRQRRRERGELAKYGYGRACWNEREKKKRWRVLLRHFHFPHTFFNPSGEVNLSYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGB8</accession>
    <name>A0A914HGB8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGB8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16699.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16699.t1"/>
        <property type="gene ID" value="Gr19_v10_g16699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16699.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26739" checksum="439A460260E7CFD8" modified="2023-02-22" version="1">MTASQQTSADKWGLTEYVQQQQQRNCCHGKKKKKLRVLRVRRKKEAPFPHLLLEANQQVISLCCVLPPFFRDVPEAVRDVPEAVRDVPEAVRDVPEAVRDVPEAVRDVPEAVRDVPEAVRDVPEAVRDVPEAVRDVPEAVSEMPTLAGKCHNIHFFSILRPVLPPQGINILAWVGGGWVDVWRGWREWGQSVRNVGVVGEEKGLKMAEIREEEGPLGGWGREVHSHQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHH6</accession>
    <name>A0A914HHH6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914HHH6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17402.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17402.t1"/>
        <property type="gene ID" value="Gr19_v10_g17402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="949"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17402.t1"/>
        </source>
    </evidence>
    <sequence length="1025" mass="116544" checksum="F85EF808D61D4A8E" modified="2023-02-22" version="1">MPAEAANSNPNASSVTTSAANNAISTHIVSEKNKDEAMEVDEQLGSDDVDILQSNLEYAFGVSIDDNSGIAQQFTSSPESLLQLQDLVRAALSSMAGKDEIGQSLLLDELISLAVNMIKSGDGFVSNSSVANADDALSALLPQFGLALSSVASSALEYLIGLRNRCDFLLTKSKDVAKCVAILNLLERRIMVQSTLFFRGLLSERCSYENVSAVFLERLLSEEIDTFFVHQLILCCRDSSSVDSAALVEVFNPILTLMRALILNATAEQKYNEIVEKIFMTLKQLLEVKLRDNTRPIAELIVLRPDFHPKISLTKNRGREFMSTSFLGPFLSLSIVGCQSFDLCFENASDAFSNAKLSETEKEQLMTTHRVWLGNLRLNLHVVVHALVVNGSTRLQTLDYIGHLLATNRKLSQLQADFSQLANFTEKVQGDYLLHPKCRIDSTDEARIYMDITTLESHRQTLDLTYTPNFNTECFFLTVEYMRISLIAMMNAHSRLRRFYIGDIRRRVQEMEERLKSLGASANAAQKSRIQSALNKANEMVKQFTVSADCYQCLLNDPNLVEKCVLFTNKLLRLLLQPIMPAFGQQNFEPSFDRFYSFPESYLEVAVEFLNFLLSNSKTARIFLKNLSDFPKQLLHLLLNLENIKNPFIASKIADLLFMLCPMVNQEASGFYRQIVTDPLAVEGLFPALVKFYSAVETTGSHTEFFDKFNIRRNIQVIFKCMWSDLSHRDRMVQYAGESSPSFVRFINMVLNDTTFLLDESLDKLKMIHDIEAILSKETEWNKLSQDEQQRKTEQLRDSKSQVKMWIQLGSDTMELFVTLTNDAPEIFRNEALGERVAAMLNHNLVQLCGPKCAQLKVHDAISRFEWDPRTLTQQIVMVYINLGSKMFAEQIAQDERSYTPETFATILERFKARNILTVNHLELFTHLAEQAEAAYKEKMSFEEEFEDEIPEEFKDALVYTLMSDPLLLPSGQICDRKNILRHLLSDPTNPFTRQPLTTDELKPADELKTRIKRWVQEKRGQSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHT4</accession>
    <name>A0A914HHT4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHT4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16758.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16758.t1"/>
        <property type="gene ID" value="Gr19_v10_g16758"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16758.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24018" checksum="A6F6B020A8783125" modified="2023-02-22" version="1">MRIKRKNGRKNEDEKEEKPSKIEGQKWDDCHHRELAGGVAAVAINKRVQAAAGGFQLQRKTNFRPSTTTASSSNHHPPKTPPNDGQTVDDNLPHFHPPNHPKGYSPRGEGRGQRSSPSPSSSSSSSSSSSSSSSFSPTRTPPIACDKQQQEEEEQEEEEKEEKEVNVRERRETDGRKGVQLQMEMKRMDDLEEEEEEEEEKKEQHLRGSSSSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIB6</accession>
    <name>A0A914HIB6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plus3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIB6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17429.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17429.t1"/>
        <property type="gene ID" value="Gr19_v10_g17429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="235"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17429.t1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47140" checksum="A190826D35596593" modified="2023-02-22" version="1">MKTNKRQKVSSSEEEFDPNQKGEDYDLFMDNEEREKFDKMTEKEREIEIYKRLEQREIMKTREKIKKKLEMAAGKKADEEGSSSQKKRKRKISEESNEGNDDDKEDSPSEAGEVDSSSDEPKESSSSKGAVKAEPDESDGEIDADYHKPSEVASKQSKKKAMAELLSKRRNKRQTEEKRRKETLKATLDLDEVFGNEDDEGKSASSSSSSVSSSRSSSPDLGKSRSPSPVAKQEIHGRDELIRCQLFRRKLAKFVHAPFFAKTVVGCFVRISIGPNKLDGKQVYRAAQVVEVVETAKIYEVEPNSDIRTNKGFRLKVCDGEPMRVYRLEFISNSHIVESEFLFWLNKLRSTNTPVPTVDFVDRKRKEILDALTYNYSESEVNLLIKEKQRFKRQPTNFAFQKAELLKTKVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIR1</accession>
    <name>A0A914HIR1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 4 regulatory subunit 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIR1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1701.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1701.t1"/>
        <property type="gene ID" value="Gr19_v10_g1701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008287">
        <property type="term" value="C:protein serine/threonine phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039918">
        <property type="entry name" value="PPP4R4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 PPP4R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="885"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="956"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="956"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1076"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1701.t1"/>
        </source>
    </evidence>
    <sequence length="1163" mass="127573" checksum="0176E4A7E5061254" modified="2023-02-22" version="1">MKKVDNSNAVAPGDSAEDAAASASVEITATELQKEQRKSLDALYAAAREEFDLDMSPVDSALKTLRDGREIQKLSVVRNLVELVEGEPEDALHRLLPMIQELLSVEPSNLDMHCEAAVAYKNCIKKKKLQQKCPELSDRFLAAILDNIETQKENVAATAWLESLVDIADCVSMQSVTNMVVPLAVGQADSGKRVQRRVISTRLIEKLAVLVPNEILQRELSPCAQMLCQDSSAVVRTSIAQKLYVLAQSLNNSTDCCTLLLPCIIQLCKDEDPSVREAILSSMAVCLPHFSKDAKKSVLLPLLRKCTEQALILRDASLPMVSRHLGSWLQCLRDILTPIDLRWWLDIYVRILDFAWQQQQQNGGTHRQQQQQQAQKQDFPIKNKLPPAAVDNGTQMAANESDVNMPAAEGDGQQQKQQQLCVACRRMCAYNFPCFMSVFGEVTEVFSGRLLPILEQFCRDSDDEVRSIIASGFHEIVTHRKLVPTTTTTTTTKKLPKNSPKIQQSSTPVPLLLGPFIHLLSSGNSDIVQQLTANLHRILPMLYADISASGSKRQTHLIFTKLDRILVNCNSLMKGSGSWRAHEAYLNGIAVLRNLVKPKDLMSTFVPLLKQEVLTARALPCRIAAAQTLLLMMREFATNRSRQPIIDFFVCDITHHQSCYRRRILLDIVPSLLQYFSREFFIDKFLYAVLKLSTDPIENIRLQLCRTLPKIKQYLVFPNNDESLSSLERVVRELLASEKNALSRQLIQQSACELSRTEMDKSESRTNRAKLAEEKRLWTELEESVDDEEEAAEELLVEKCRKTPHFVGDDGGGSPESGIFFEEDCWLGTSPTAAANRPHQQQFGLSRSATTSCIPHQLEAEVQSNLLTITSSASSEMLSAMAIEPFATSSPKTSRRRPPPPPPKSWRNTTTIRSMNAPKLAIVRPQPQVKVVNQRSSSPMPMAIEEQKMLNKLGGTAAATTAARYRSTSSAPPTPPPKPQLPMCTSSGGSPSPYTAVDSGTSSVIDSIKLKKYRPRDISTTTTMTTRKGSLPGSSTTANASSALAHQSTTSRGSVIRSASAVPAGNDGGGGTMPKSSSPSSSLPSSRMVVQRSSSPTAAAVPLQTSASVTSMPNAGSIKQRNGSGGGGGGGGRRPYGLMRVQSSSSAVERKPAQMSIRVISLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIT0</accession>
    <name>A0A914HIT0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIT0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17766.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17766.t1"/>
        <property type="gene ID" value="Gr19_v10_g17766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17766.t1"/>
        </source>
    </evidence>
    <sequence length="623" mass="67177" checksum="C8AF42CEAAACF675" modified="2023-02-22" version="1">MVIVSEEEAVAEQPETEQVQQENGSAHSEEEEEEEEEAPQVRRQQGQIRMVTSSAGGETVQTEDSVAAAVPGSPTVAQQPPQSPAPTQTAAAPASPAPASAAPQSPAAAGAAATAQQASLEEAKRRQQEAMDKARAEALRLQEEARARAEAARQQHQQQAAEQARLQAEQQIKAQQEAAKRQAEERTQQLQQQAAQVQAVQAQQQQPLSPAATVTKQQPQQQKPTPAPAPAAAAAAPQPTKTPAPPAQQSQAPKAPQPAPPQAVPAQQPPKKPTTAPQAAPVQQQQPKPAPPPASAAKQQQPKPPVQQQPKAAAAAAPRKPTPPAPAAAQARAPPPVVREVQLPEAPSKPILQHAEYTPKLVDSIVNKLPPGQAPEEQQLDQGSAPRNPIIEDNAWQVQCRVQPEYQPVQPAKLNATGDFLVESEAKKSIVPEAVGYSKVQWDEFPQEEEKERQSVPKVKAQEWVPEHDVEHHVQKTVYQPGRIGPDPNTGRLWPPPGYEEEEQIEVGNAEKTKCVADDGWILANGAEPEEDGGGVGNAPWKNNARGGDVKNRQWPPPENLLEKELGGGGRISAQWPPPEQEELEQQRVEILQTHIPVKDKVRAWKPRTLFPQFETEPTEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ22</accession>
    <name>A0A914HJ22_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ22"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17838.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17838.t2"/>
        <property type="gene ID" value="Gr19_v10_g17838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF17">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17838.t2"/>
        </source>
    </evidence>
    <sequence length="309" mass="34078" checksum="698CB42590B36D2E" modified="2023-02-22" version="1">MPTIRHVNIKKPQRALCRLERSNSLVAGRGNATLAFLPELNPQQVANLRRTWKHINTKGLYDIIRRSFRKVESANPSVALAFPAAASETNSAAGDNGNLPQTKYCGVMEHSKYFMVLLNRIIDGDPQEQDLERELKQIGARHVTVYKRFGVGVTAIERTGEALAESLFKLDGIRQSKETTKVWRVLIAKIVDHIESGFTDELRSQRRQTSTALLSSAAGALAAPLFDNKFFKRNSVPSPHNHKSSVRSASNEERDDDNGGSPTTTPASKAPPPPSAVPYQQQQQQSSSSSGSCFLRTELAGVVRRLSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK18</accession>
    <name>A0A914HK18_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HK18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2193.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2193.t1"/>
        <property type="gene ID" value="Gr19_v10_g2193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2193.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17529" checksum="C3F270472AA2E046" modified="2023-02-22" version="1">MQTLCSLLSPPFQIDPVTKAQITALHNCFDINFVMSWQDLVNNNLIGTGHVSKAAICGLDGSIWGKSDNFKLDATEVTAAMNGLKQPDAVLASGLRFEGEKFFVLQADTERIMGKKTANGFFIYKTGKAFIISIYESGVQPEMCSKTTVPENSCNTPNSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKH5</accession>
    <name>A0A914HKH5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKH5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1965.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1965.t1"/>
        <property type="gene ID" value="Gr19_v10_g1965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1965.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13911" checksum="761B178C77F6BC61" modified="2023-02-22" version="1">MLPHQQSATHARVVCTKMHALSPFVSSSQSSARDARPCSRQPTHAPAELHGEEEEEHVKRSPLSVRLSVCRFISAHYIFLYFLNLCAHTRTSTRQHGATVSLNFRPLSHPFWSPSFLCFLIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL08</accession>
    <name>A0A914HL08_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL08"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2300.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2300.t1"/>
        <property type="gene ID" value="Gr19_v10_g2300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080049">
        <property type="term" value="F:L-gulono-1,4-lactone dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016899">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p10" evidence="1">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="211"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2300.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32766" checksum="32A6CCA763C76DFF" modified="2023-02-22" version="1">MTKSGAIKRGQLQILDRQTQAFFFNYCRGVSNAGKRAAMRMCSTNETAGGVLLQPMEQRKCATDKCLRVLPRMCMALEKPMCSKNCGRGFRRRKVRCLAARRNSVLADKANDHTFALTEYGNRVSYGTLCTILARHRGQAQARIFSVDFMVAHSSFPRYISWRCTAHGSWFIQAICKGFSEMAAQTDLLTMMTEVNALVQRLELHNWGGNFYFCTQNIQYPRTTAEVQHIVKSAKKLRVIGSRHSFTKIGDSCGTILSTLGMNSIIKIDKASFTVTVQPGITYTDLSPILCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLI4</accession>
    <name>A0A914HLI4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloprotease TIKI homolog</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metalloprotease that acts as a negative regulator of the Wnt signaling pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="13">Divalent metal cations. Mn(2+) or Co(2+).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TIKI family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914HLI4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2606.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2606.t1"/>
        <property type="gene ID" value="Gr19_v10_g2606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14789">
        <property type="entry name" value="Tiki"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040230">
        <property type="entry name" value="TIKI1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120">
        <property type="entry name" value="METALLOPROTEASE TIKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120:SF6">
        <property type="entry name" value="METALLOPROTEASE TIKI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036872107" description="Metalloprotease TIKI homolog" evidence="14">
        <location>
            <begin position="22"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2606.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41502" checksum="6845B740F91BD3B8" modified="2023-02-22" version="1">MYLTWLLFAAIVVNLVMKTVQQHVYLWKITHPDKAKPSYLFGTMHVPWNILFKKIPFENIIKNVDVVVIESNTDLGSELRDCVRKRRPAKLPQNVVKRIKKNFPLYHLVLLPLPSDWLLLSLSSLIMQKQLNVFYVTFWASLDDKIKKIGKNNGKETRYLETPNDLRIVLPNVKEKSMIALIEQMLDIMENSKQTLKPLVKSYKKGEVTEQLYEDYLFGPIPSEKANELNISKEQYRIDLNCARNKKWILKMNEWMMERNNGEKSFFFVVGLRHIITEHESLIKLLTNEGYKVEKMNDFISSDATKEAFDDDKTATKDNQRPGHLKGHMDFFKWILKNAIEENETPQKGKQRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLX3</accession>
    <name>A0A914HLX3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLX3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g27.t1">
        <property type="protein sequence ID" value="Gr19_v10_g27.t1"/>
        <property type="gene ID" value="Gr19_v10_g27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g27.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10059" checksum="1017CF7AC71B858A" modified="2023-02-22" version="1">MSDFGLRGKDVSAPLVCDGDASAPVNSCWLVLAPKRPWRRNGNAKTSPAPWRNVFLPHTTAAVAKRSAPNPALPPLVGAGRLGPAFWAPETFEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMZ9</accession>
    <name>A0A914HMZ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g2657.t3">
        <property type="protein sequence ID" value="Gr19_v10_g2657.t3"/>
        <property type="gene ID" value="Gr19_v10_g2657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF328">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037985669" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="100"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1076"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1107"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1176"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1204"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1230"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1243"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1285"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1302"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2657.t3"/>
        </source>
    </evidence>
    <sequence length="1338" mass="149054" checksum="234107288D21DAAF" modified="2023-02-22" version="1">MTDINTLRLLFFLFLYLKLASGGAFYENEDGNKNKKSSTIKVEELSDEFILHQISTPQKKFPPPVQKATRRCQCGRTELAQMSPMELTNLEDGKRISLLCDNENKLGSGTYSKVLHAELTKGNNYKKCVALKMTRRKIMKNSDWQKHKKEWKIQKAFDKLPEKERKHVIKLLAYGYYKKMKKNKEKEYVFSILELGCHDLIGHMKRRRVEWFSNNIQVDDRAIETDIRQLAETVRDMHQLIMHLDLKPYNLVYVREGKNQLMKAIDFGASQFINEEARDQQGHEVQQANACKWFVVNDPLTTKLYQSPEHYNQCNWNYDAQKEHSMELSSKSDIWAFGIITFEMALIGSEFKWTFDEKSQKDANDIEAQVQNAINDLWKLYIENKDIEQLEKDWRFPRLFHLITAVLVYESDERPTANGILDFLDGKCRFESMLNKPSRLFPWLSMAQFKAHLENKNNLLKKEFKGSKGSNKKLLKEVAEVEQLLRMANVEEWKPSDAQRNVPCDTMTNRPKSTVAMPAMAENAIQRTYFGLKNDNNKKWLTNLEKTIGLSLSPSITSITVKHKGLFENLQDSFYNRDLEFPGAMGNRFVDLLSTIGYGNLLKQLDIVNERYKSDAQMLKKVVESVRKRLGAEWEKIYALALQYECDEEESLYVDIIEQTSALYLYELVYKQLLDQFNANDFLRKESSQEKFLSKWLESILANLKSYHTEKEKGILMSIRYQKEQFETKERVSSIEMEETVKMIRDEYNQQFLELKDIEYQTIRLAAAIGNVSDFRQMKEWINSLKKQENDLLFVKKTTQEMLKDVKNQLTFLDEELKEKMLRIQLTNEKDLEAIRQGLELCKLVENKIVEFQKILPIIHFCCEKIKGIFEKLLTQKFECAENNWIISTSHHRCPGQTCAMTDGLNEGERGELLRSQLDPCRCVAGRTFRCRLDGAEEEASSLTTSPPLLPITTASAHSSFFSSDDISHSDQQDRPVRSAPLTAKKMGELPTGALTTAAILAITSFGAILIGVPLMLNDVANLQSELAQKSQVYMDMSNNMWRDIMTQGEQSRKEHANIRQRRQYGGVGPAVASSPVGSATASATCPQGPKGSPGYPGEPGQDGQPGLPGGVGVAGGGAAAFGSQQGGQCAPCPGGPPGPPGYKGKRGPRGEKGAKGSPGLPGREGQPGEEGPEGEIGLQGEIGEAGPRGPPGEQGIGYAKGEPGPKGEAGPHGEAGEEGPPGERGEDSPPGPPGEHGPQGPPGLQGKAGEQGPPGAAGPPGAPAEYCPCPERSNGQPGAIGPHAVAGPQGVASGPAGGGASSSPAAPPHVAGGGPAAAQQYNKYAHAAALRTRHRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNF7</accession>
    <name>A0A914HNF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2916.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2916.t1"/>
        <property type="gene ID" value="Gr19_v10_g2916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="204"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2916.t1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45509" checksum="76FF0092604C9362" modified="2023-02-22" version="1">MPALINGGHITADPENCATFSNLDSSGEVRLFSEQHRNRLEMNGKIGNFFSILNPIKWLRCDPFQIVGSIIIFIFIIYAIHGLNGQKKNGLKMNEQQKEMREMNESLKSGQAMVVAKLEEYQNKQHHDTDALIEAQKKNEQLNDLLGQFVEEQKETNRMLRNQMDELGNSSKELQKGMNQLKNELIAKMEQYQKEQQQNTGDLQKTVAVLNDTTNGKSLIRQQNRWDSAACHENITLSEPDRLIVQYNAGKYYAGDDRSVLAERPIPKGNSGIFYFEVKILEYAYGSSIGLAPKQMPLGHWVGRYEGTYAYDYEGSFWVHAHAFDGKQPPEFGAGDVIGCGVNLATRQLIYTKNGQRLDTAHLFVDSDADLSDLFPCVTMSHPGDKIEANFGPNFKFKIADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNR9</accession>
    <name>A0A914HNR9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding PCMH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNR9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2299.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2299.t1"/>
        <property type="gene ID" value="Gr19_v10_g2299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080049">
        <property type="term" value="F:L-gulono-1,4-lactone dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016899">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2299.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="20944" checksum="DD62EFE97867ACBD" modified="2023-02-22" version="1">MYSQQLLFSDANNLALPNLSALAEISVGGATQTCTHGGGLGNANLATHIRAMQVVLANGSIAQFGPNRAQLGAVACGLGAFGVVTEIELNVVPAYNTISYAFANVTVVANSTEDEQMKHMSSLSGAVRTLEALTITQIEANKVQPWYYGLVFFRIGMSGNDGNEIASEFFIPYNHEFETGQLCPVPTASQPQILIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPY7</accession>
    <name>A0A914HPY7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPY7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3153.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3153.t1"/>
        <property type="gene ID" value="Gr19_v10_g3153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3153.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9978" checksum="BF10F6C6F275395B" modified="2023-02-22" version="1">MPFTKSTGRTPNLDKLNPIQLISLDELNPIQLINLDKLNPIQLISSDKLNLIQLISLDKLNPIQLIRILLSQSLITLIMPKIAKNRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQN1</accession>
    <name>A0A914HQN1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQN1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2811.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2811.t1"/>
        <property type="gene ID" value="Gr19_v10_g2811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2811.t1"/>
        </source>
    </evidence>
    <sequence length="773" mass="87871" checksum="1C4B208DD38D7FDC" modified="2023-02-22" version="1">MFTHRKNSSKRASFSILQSQSATGDIHQNRSSLLITDLPRENLIFLVIGQGCFREFLRNNSSAVTQYGTASLYNQICSLLVFCSREFTKYAEECSRSSTERITVLLDAPKVPIKALRIVLRACQSALAYKIRQCVLLEQDRLLQQRVALDVILHDKYDFKVSVCPRSKLMNYIGLASLFDLQSIWSKKAAESKQQRKSLLTDLNNNVDDAHEGGRGTLTGKWADAKKAFSVFFAANPNYSLSMGSSSANVSAASLLRLLRKDRTMLIELVEHDLDTVSVTAVAVEEMGQLDEEKRRSKGNRPTEALSNFGRTLQRISLIGGENAIAQQQRHSFVSDVSAFAVTPSSMPSQLSVGRAHGKTHAEGEFAFVGSSSVGSIIERSGHWPMEKRSDEFAGTVTRLKASVLLLVDWLEEHGEKQLLALNGQWKKLWTTFNGEIFFLDWIEAERLRLTEETERVLNEFANVRGDIEQLERKRQALGFSGKSNEHIELGQFVHVVESRIHRLRTGLNWHKLRLDNARRFKEAIGEFHKECNALILMLYDCDSRAKSQTLLLNGDHIKDRIKSIKEHQKSIEKCVELSSETEIAFRFLLHQHETGGMEPEEDGYVEEAVLRKVSADFGALAERRQRFSEFVVFWVRWLDQQLLLIEYEQRGDQIIDKFNKSLLTNNSHLFNELREDGRRLLECARQMGSFALVLRKMNSLDTKSNPDGRTLGTSMRLRDLIRQVRAARTAAEERAVVEIWQNSSTFICSMECVKLDYVASIPAVPEMDPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQZ3</accession>
    <name>A0A914HQZ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3093.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3093.t1"/>
        <property type="gene ID" value="Gr19_v10_g3093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3093.t1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50845" checksum="A5D31F38472BABF0" modified="2023-02-22" version="1">MRHFDEEETPIKICNKSNAIEFRFIVEQKYYEIKVNGENLFGNYTNSISVCEIKHVMLDGNVNLLEQDKFVPSAVAATKSKFVYVTRTKNAQKFEEAAGINTKKFESRNNELNIKPEKPTTLEILMGKDGFYGKKNNGDYWYKLCLYYNPYNKSISTLPIPPWTIDHISVNASTFDTQNIRVVKASSREDELDLEDINTCNDPGRKRILVPWKRINFTQVIKQEGVDRANYSVFVNITLEENLTPMPRVAIRFFNEALEFHDLFGSTVMWMELSTDILFFNSFVNLNKTWSEPNYGFKYMVNLKVLEDNDVTPTTDLIEQFSTDTLNPLMAPQTSSYTLNSTIDQMPNSSTFMTTTDQKKSFPLKLFFKIDVHETDGEAEFYVTLNGHDKDVNNQKVLKYQCPTNVRVPAIQYITVSHGENTLAADSAELKVSCSSAVICVNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRE1</accession>
    <name>A0A914HRE1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRE1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3013.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3013.t1"/>
        <property type="gene ID" value="Gr19_v10_g3013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574:SF2">
        <property type="entry name" value="CLAUDIN-LIKE IN CAENORHABDITIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3013.t1"/>
        </source>
    </evidence>
    <sequence length="874" mass="97418" checksum="32987E3F3230ABB0" modified="2023-02-22" version="1">MTTPNDGDDQRRVRYGWLSLFLLLLVMSTTALLMGLLTPSWQVVYLEDGRTEHHHGLWLDCKRDYSYDYGRPREYYETLHRRFDLAGPFDQFWLPSLLCVFKFDYWLDDQDWYEFGYDENRLWGDAYQHLFLGWKIAAFVAHLIAAICSLFSILMIICAYCHRLCTCVAAVLVTLSVVSGLGGNVVFYAFASDQNTNIIKEEDGIYEQHFGWSFWVSIVGNCLMLFTSLLGCVATKAVLGKSRTKFIKIQTDDDFDDDNTQLLRLSATSSTYVPQQQQQQHQNGTNRRQHQQQQQQKQFGRSPQRSTIYRIESNDLRRWERERMRTVEKEGHFKRTNSMPMIRRQFVDQQMQNASSISDLSRPIVAGGASHPFFPRRDSPMVNDHELAGGAAMDVIYEYVDQASLSLASTLKAGDFVRSKSKLNVYDPVPAFSNGNQQRRVESTSIGIVQNRSAPAAADHHHHQQQQQQQRQQQLLRLERREMFETANVADTEYLQPKSLTSGGSSGGDNHSSNSSSAAGRQTPLIVPIAANNAAFRGFSRERPAVPPAPPTTSSSSTFEATPAAVPPQIPLDTFPHKTQQHQRQWEAKMLLELKKQQQQQQQQQQHMAEEDKQQQQLQHNIHYHQQKPAPPIGRARPASERRLCPPILSDVPTPPTAPAATVPSVATVPTTVATVARDDVYRIQINTFQPMADDARHSSFLGTFNNKYSRSITDLVPAGIGQDSFVRAAFERGPPTESSEQSTTPTALSSAAAAAHSDYRPPTFLGVEALPPPMGSTLLRQRLGSNPSATTTLRGPDLRNGGGGTPPQSEADRSLGSSRAATFLGSPPTAAGQNVPRTFGQNASGNSGQSADEMAPRRMYFGQNVGTAPGTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS26</accession>
    <name>A0A914HS26_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HS26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3716.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3716.t1"/>
        <property type="gene ID" value="Gr19_v10_g3716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3716.t1"/>
        </source>
    </evidence>
    <sequence length="348" mass="40153" checksum="D4F9E76B9ED899FE" modified="2023-02-22" version="1">MVFFEWFYSVQIPIIYLAICITIPSTALYIAEIVTIVRHKKFHNSFYALFVMRAIPDLLYVLDSFYGYRLPSIIGAVLYPIYSKFPNWMLAMFYFFAGHTLQANNLVTAFILLNRLTAIIMPIKHEKLWHKFLPFITIFVLCVPTLLYWPAFKMNAIILLKDPNSTTDRSFVIYEAEDEPYFFNYSVYINTASSVIFTISCVLINIATFLACKQQLKRVGANGNNFHNIERKLLFYAFATFLGHMLVASMFLMIPIITNLDDPKTKDILFIYNTLVMDTGTVMLSSWLLLWANGTLRRQLIKDFAINRIKNNRVGPMEGPRNNNHRPVGGAVGHQLQDRISRQLPPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU43</accession>
    <name>A0A914HU43_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU43"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4213.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4213.t1"/>
        <property type="gene ID" value="Gr19_v10_g4213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4213.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7068" checksum="A77BEC4DDC5AEE86" modified="2023-02-22" version="1">MASSSSSSSAPSIFCTSNSTSPSATPLVNAMDDGRIGWIGRNGAKRDVKDDATRAKGSCASSTANQKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUL2</accession>
    <name>A0A914HUL2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
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            <taxon>Heteroderinae</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUL2"/>
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        <property type="gene ID" value="Gr19_v10_g4813"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g4815.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4815.t1"/>
        <property type="gene ID" value="Gr19_v10_g4815"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4813.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4815.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="19865" checksum="598C3CA2AEC383C9" modified="2023-02-22" version="1">MDAIDRDLLGACCAGELEAVNQAIENGANLDVPDEYGHTPLMKAAMCGHIPILDTLLANGANVAAQDSQGITALGYAVVEGYLDVCEKLVSGRAGVHQMAFDGLRSPWLIACAEGQYDIVEMFVIASGQLKNLDHANADGKTGLILACTKQRIPTMQFLREQGADVNKKDRFALDYATELHLDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVY4</accession>
    <name>A0A914HVY4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVY4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5171.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5171.t1"/>
        <property type="gene ID" value="Gr19_v10_g5171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5171.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18834" checksum="535B0334DC257829" modified="2023-02-22" version="1">MLADRKGEGMLADEGGRRRGCWEKEKRMLADERRGRREGRRGCWLMKGWEGKGSWLIRKEEGKEDVDAAAEPKGREGERMLADQDGGKEKGCWLIERDEREKRMLADRKGGREKRMLADRKGWREKRMLADRKGGREKRMLADPKGGKEKSMLADRKGEEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW76</accession>
    <name>A0A914HW76_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tyrosine aminotransferase</fullName>
            <shortName evidence="13">TAT</shortName>
            <ecNumber evidence="5 13">2.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15093"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="2.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="5 13"/>
    <dbReference type="AlphaFoldDB" id="A0A914HW76"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5237.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5237.t1"/>
        <property type="gene ID" value="Gr19_v10_g5237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005957">
        <property type="entry name" value="Tyrosine_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01264">
        <property type="entry name" value="tyr_amTase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="10 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="16">
        <location>
            <begin position="87"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5237.t1"/>
        </source>
    </evidence>
    <sequence length="492" mass="54167" checksum="41D9140775CE2470" modified="2023-02-22" version="1">MAQHSPRRQQRALPKASALENCCYSAMAAPIKTPKKAKMHLNAPKRHQINEHSEWTTMRSSKHSRDTVNPIRRVTDSLSVAPNPDKKPIQLNLGDPTLTGCLPPSESVVAALRDAIDSHRFDGYGPAVGMQTAREAVAEFFSSREAPISADDVVLASGCSHALEMAIVAIADPGQNVLVPCPGFPLYSTLCQPNGIKTRQYRLKMEEDGLIDLQHLESLIDDQTRAIIVNNPSNPTGVVFPQEHLEQILRLAQKYKLPIVADEIYGDLTYAEGAKFHALASLSPRVPIITCDGIGKRYLVPGWRLGWLIVHNRFGVLSDVKAGIVSLSQKIVGPCALIQGALPRILRDTPQSFFDNIKNLLSQNAQIVYDILARVPGLKPLRPQGAMYMMVGFDPELYGDETSFVQSLISEESVYCLPGSAFSLPNWFRLVLAFPEETTREACERISAFCTRRLRPCRKQLALWGSVPDEEDGGGSEGAERTAESTSDEDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWF9</accession>
    <name>A0A914HWF9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWF9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5296.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5296.t1"/>
        <property type="gene ID" value="Gr19_v10_g5296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5296.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21606" checksum="E950C5B6AB6A71F3" modified="2023-02-22" version="1">MVLVSVYCAQLLNIKVRLLREKLTHPADREAVLRLLKGKQVRTTYADRNGFKKTFFIDGLTTDGAAHVMAYGRLPRPYNINVAAHYFARHRIRLHNPYTQCIVEHPIRGEDRFYPMELLEIVDDASFITGQIQAGLGRVFTEIRDRHSSSKTESSEESDDDETLTGFQTYTDDFAYTGRALCSQGAPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWH9</accession>
    <name>A0A914HWH9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWH9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4798.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4798.t1"/>
        <property type="gene ID" value="Gr19_v10_g4798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037678581" evidence="1">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4798.t1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49582" checksum="6ED33566CE91FC41" modified="2023-02-22" version="1">MASVLNVAFCVSICFYFNPCESVLNATNKVASSSALAVIGPATAARQQPISNIVPKMKLQSSLIDSFQSYSKQHLFNNGKEIPRKSHRNFSSKLFKKNVVNALGEASGFPEKVKSRFNYENQLEIMLGNQLDILSQRILFNRRISESNRRHHSIQKTDIPYNILAIKSAKVDVQTLREKNVNDGHQQSVGESQNQLIMEVAKAMHAAISFSNNSMKDNFGKFFDCDQREQLRFVGLVLWHLVFRDCPIFDLTAEEFVFIAKIEPNIDATDPTVASAMCAELDNELASKSEQMAKKGDVNLSEEMQKQFLKEFKVFKMLEDKIFESRQEGVDYEKYNELHDKFNLLKVYWNWVAGNNSENKMPFYDIIDRAFIAYGKEAPALIVFVRALLEGAIDWMEFSKCVQSPTPNLIECVNSEKYTQMAGQLLDISKKYGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXI3</accession>
    <name>A0A914HXI3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXI3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5044.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5044.t1"/>
        <property type="gene ID" value="Gr19_v10_g5044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5044.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25253" checksum="E8463D0561C18094" modified="2023-02-22" version="1">MRPASSLFTLYSAGVIRITECKCGSLVDKYVEYDIVLVLIDLVLQYRQAYRHVLFNSNSKSFNRLIFIFVLCDAYKAWIERVEHLPGSQILFDLEWRFYLSLLRSAAEFGAYTSALFCFLKFFGQFDKFAGGSRGPRCFFESTLVGFYGSLFVVVSIIWQLHGHISYRFLTRLFIILSHLQVQRTLFPGIGLKMNLLAVSVAVSAQIVTGMAFQKFSVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYG2</accession>
    <name>A0A914HYG2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYG2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5263.t3">
        <property type="protein sequence ID" value="Gr19_v10_g5263.t3"/>
        <property type="gene ID" value="Gr19_v10_g5263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5263.t3"/>
        </source>
    </evidence>
    <sequence length="85" mass="9693" checksum="CB3B62E2E25A76A9" modified="2023-02-22" version="1">MLITKPDIQETVAQIMAMAYLYPSHPRMTAFWIGPAPTVMVYSATLLESITMAWQRLVDKLCRTMETKTFSCTKQRTCCQHFATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYP0</accession>
    <name>A0A914HYP0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HYP0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5319.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5319.t1"/>
        <property type="gene ID" value="Gr19_v10_g5319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5319.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19597" checksum="D6288695F02D87C9" modified="2023-02-22" version="1">MEQAIPEEQVFHQQYIDKNGVKQGWLAPKNVGNEMLGRVTSSDGKHRRKKEINSQFKHSDSEKLELMEKYYKIKQINPKLNVIDIAKRLNISPVTLYKWKKQFDSNLNKNSVNENSLPENSPTFTDNDTSEHPMPSSDDNLWAWNLVKKKRTERIQVDTLREEIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ21</accession>
    <name>A0A914HZ21_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5348.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5348.t1"/>
        <property type="gene ID" value="Gr19_v10_g5348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5348.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17684" checksum="A3E80D63A6B922C9" modified="2023-02-22" version="1">MPNFCQRIASSVAVLLFAPLFGCFIFLPIFISIQNGNSILEEGSLRPKRVAEDGDNTSKIEYSTDCSIATGLCQQCDYDLRGAVRECRNVSMPQGNWGIGRKSHFNNNWGPFTMGNLFFGAVATHKSNDRPLNKSKFDKIIRTFNGLSHKSQRMTILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZB0</accession>
    <name>A0A914HZB0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Innexin</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZB0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5874.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5874.t1"/>
        <property type="gene ID" value="Gr19_v10_g5874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5874.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16896" checksum="A3A08E5571134521" modified="2023-02-22" version="1">MGTDNAGGIWMSIKDCAMEHYKLCWMSDDILFCHILSLKMAKSETIVDRFQFCSFLFGYVYSTLNKAQGQTLQRMVLVLKWNHDLRMFSCLWAIMSGRGGDNIANVVYHELFDDVNITPRLQHSALSEVEKNKKWGRIYQLKRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZC8</accession>
    <name>A0A914HZC8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZC8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5424.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5424.t1"/>
        <property type="gene ID" value="Gr19_v10_g5424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037194768" evidence="1">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5424.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20116" checksum="A71619B9D1CF5FA0" modified="2023-02-22" version="1">MTSLPLLISLLLCPLVLSDGILRFNSSLHQSPPSKMPSKMSQIQLSKKDQVALDEMLLALRHKTPIEQTHDIKLFGQREGGLMKLKIDAILEEYGQAVEVFKLNMAPKLEAMSWKEARACGDHVLLIMTDPKLSSAEKVARVADAVGRLSEPAQKELMEANLGDAAQIIQKNGPFLNGPAYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZU0</accession>
    <name>A0A914HZU0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZU0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5301.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5301.t1"/>
        <property type="gene ID" value="Gr19_v10_g5301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5301.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34124" checksum="CC75501220A45A8A" modified="2023-02-22" version="1">MAFNINDKRSLFDSIIPSVNFSITSNSITVASERLSTPRVIPFDIPGKCRHCKSTEGDMDYMVTKEGVTVWCSRINGPAFVPFDFVYDLPGHTFFKIKNKGRAFDVEHVQAQHAPTVCSPVAVQLAVPPEPKSVEQQSMLVDNSPSPLNITLAPAHPAQEADHRQQQQQQQQQLQDFGNTLMDVSTFLPAEQQQQQVAGTTFTAQQLDELVNTMSAAATLLPSQQPQQHIEQQPQQQVEMQGFVDAMSAATTFLPSQTQAASPQTAEPKVTKKKKLEKRKPSVEAEEEEEAAVKTIEQPQNINLRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZW8</accession>
    <name>A0A914HZW8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZW8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6201.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6201.t1"/>
        <property type="gene ID" value="Gr19_v10_g6201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037732383" evidence="2">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6201.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11125" checksum="0AE3CFD04FDBF346" modified="2023-02-22" version="1">MRHQKNRCLLLCCAILSATSPICSYANPPTRLMTSTPFKNREKEINPSHKKNRKNISALSPISLPKCDSDQKVKSIFNTSINSDQLLKSRQKDGPFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I084</accession>
    <name>A0A914I084_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I084"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5695.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5695.t1"/>
        <property type="gene ID" value="Gr19_v10_g5695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5695.t1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40694" checksum="27A910ACF91FED39" modified="2023-02-22" version="1">MQQHSLSFRDVRTWRELLAHRLALCDREDKLLRHLHTFVGGQIAHPPMVPPLPDKAHLWDGIGTAVDENVAIFDDGRQFVDVTEEGLSSEQIEQAITALAQFHALSTESPQLCGADTLPTLSHPKPENELVIKEWLLDVLLTLPECDYFRKNEHPLRNFLQKIGFGFKDEQIVADSPHKEFPIVLCHGNFCVNNIVFCSPDTKCVGKSLSPIILSWELAHPGHGISDVVHLLLSSVNSSVRIQRQDQWIALYAHKFEQFIQLQRKQNRNGKSSMPQMLARNKKMENAVKKQKQKFRALLPGQLLRVLPKLAMDYRKLAETAQLNSEQIGQYNWKRCALLGRMIGGFEMVRKDFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0G5</accession>
    <name>A0A914I0G5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0G5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5467.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5467.t1"/>
        <property type="gene ID" value="Gr19_v10_g5467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16183">
        <property type="entry name" value="EFh_PEF_ALG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF8">
        <property type="entry name" value="SIDEROFLEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="680"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="747"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5467.t1"/>
        </source>
    </evidence>
    <sequence length="855" mass="96462" checksum="9E48DE30A36BAF67" modified="2023-02-22" version="1">MPGIVVTVVMKPNEHAFDHALVNHLMIKPDISKPRWDQSTFDGRARHFFAVVNPLNVLASGSELENSRKIVLDYRKGKCSANLTVAQLWHAKHLYDSAFHPHTGEKVMLIGRMSAQVPCNTLITGGMLSFYKSTPAVVGWQFINQTFNAIVNYSNRSGDSLSKGQLLQAYCLATGGAMSVALGLNHVATKMPPIWGRLVPFAAVAFANCVNIPMMRRKEFVDGVEVMDENGVPLGKSRKLAWWAIPQVVISRIGMAVPGMVCIPMLINRLDRYKWFCARPWLSPVLQTALCGLILTFSTPLCCALFPQLSSVKVAQLEPELKNRIYQQYAGADNDGTQTVPELVFYNKGLLALSLKSASSARTFQIGDIGGKEHNGNHSPTDGQQSVAKLMGQLAKKGLNLVLNLGDNFYENGVTEKDVEERFKTNFLKVFGTVGSETVPWYTIAGNRDYKADGANISPQIEKTTGKWTFPAPYYVIHYNFGTKARRVAVRFVMIDTVILCGQNRKVFRNLKESPVEKVEASEKHFEWLIKQLHLAEEGVDFLFVAGHYPLYLTDGDRSFSCAKRLQELFLHHRVSAYFSGHEHNLKYLSIKGDVPRIVSGAGSRMESAIYENHVPKEFGEQLRFGYPDSIEVKQNGKIVEDKHLGGGFVAMEIDEETMEADIKFYAAGIDHSQLHKMASPQPDLQHIFQTVDRDRSGQISADELQQALSNGTWKPFNPETCRMMISMFDSNNDGGINLQEFRSLWDYINDWTRTFRSFDRDSSGNIDRDELVNALTQFGYRLSGPFYDMLMRKFDRTHIGHINFDDFIQLCVVLQTLTAAFREKDTDRDGWIRIYYEEFLAMVFSLKMAMMEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1E2</accession>
    <name>A0A914I1E2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1E2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6400.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6400.t1"/>
        <property type="gene ID" value="Gr19_v10_g6400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6400.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14615" checksum="564D5F47744D7C07" modified="2023-02-22" version="1">MVIWKRQNVWLQCKSIRRSAASPKPGILGASANADRVCAAQWLSQQTAQDAQRELERELQKVKLSGQYAKVLKELPILNGTESKEAIIDFFTALETRTTEWSSERIVEVMQIKLKGKAQKATTAAVNRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I472</accession>
    <name>A0A914I472_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I472"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6728.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6728.t1"/>
        <property type="gene ID" value="Gr19_v10_g6728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6728.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="15029" checksum="C88BAE677ACE318E" modified="2023-02-22" version="1">MLAQRNNMLAQGNNMLAQGNNMLAQRKQHAGAEEQHAGAGEQHAGAAEQHAGAGEQHAGAGEQHAGAGEQHAGAGEQHAGAGEQHAGAAEQHAGAGEQHAGAGEQHAGVGEQHAGAGEQHAGAAEQHAGAGEQHAGAAEQHAGAEEQHAAGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4S3</accession>
    <name>A0A914I4S3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4S3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6802.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6802.t1"/>
        <property type="gene ID" value="Gr19_v10_g6802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="134"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6802.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34694" checksum="4C9546E701044FC7" modified="2023-02-22" version="1">MANIYDEFIIVDEKSVTDFTDGRCSGGCYFRFDRTTFAELEFTMVNSQRGLQIKDIASHPTDESEPLAQIVSWKWDKGTQKIAKVNNFLWYNRHTQQRPNSGDQFNDSPSILIRILKKREVIENPCPPFSSPDDDLTVHIGDRQVTVSAHWLMVVSPVIERMLSVEMKEKQQRTLNLDGHGITMEQFMQFLETVNDHFQHGRSLPNPTNVLVLLKLADYFQIDWLKERCEAHLINCVEIPLIERFLLIDRYRLNNLKNFFLRCLNAYTLSEFNHEQLLATISKEFSDQLTFRLSAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I519</accession>
    <name>A0A914I519_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAX family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I519"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6957.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6957.t1"/>
        <property type="gene ID" value="Gr19_v10_g6957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000019">
        <property type="entry name" value="Myc proto-oncogene protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF10">
        <property type="entry name" value="MAX-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BHLH" evidence="15">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6957.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23416" checksum="AA601A72DA4DC5C0" modified="2023-02-22" version="1">MRLSLIRAGEKHFGNLGKAYGWYFIRLAPSEQNVWKDFFYDAFVKPVKRQLPHWWMFFFPTVTYFLMSDQDFSDDGMDEYSGVSPAPSSTTTDQISDSKRQARAQHNALERRRRDNIKDMYCSLKDEIPNFTNDRASRAQILKKAIDTIQKSQNEMCDLKEEIEKLEEMNTSIRNQISTADKCQAQKQQKKMIQQHPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5C0</accession>
    <name>A0A914I5C0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5C0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7464.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7464.t1"/>
        <property type="gene ID" value="Gr19_v10_g7464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="45"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="240"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7464.t1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43523" checksum="F2592D41324A5343" modified="2023-02-22" version="1">MFSVISDDSLFILLNQTGANYYLRLQLPDLILNSLKIKNNFTRLTMEFPWEVIKKAHANGFMNVDIPSEYGGLDLELVSNVLISETIGYGCTGIGTVILGNDLAATPLIIGASEEVKKKFLSRLIDEPIMASYCVTEPGAGSDVAGLKTKAEKKGDEWVINGSKMWITNGGVANWYFVLARTDPKASTGTAFTAFVVDGDTPGIVRGKKEINMGQRCSDTRAISFEDVVVPSSQIIGAAGEGFKIAMKTFDKTRPIVAALAVGLAARALDEASKYSLERKTFGVPIAQHQGVSFLLADMAINLELSRLMTYKSAQEVDSGRPGAYWASIAKCFAADTANQTAANTVQIFGGNGFNTEFPAEKLMRDAKIFQIYEGTSQIQRLVISRQLLQRVAQTGSSYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6J4</accession>
    <name>A0A914I6J4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6J4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7085.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7085.t1"/>
        <property type="gene ID" value="Gr19_v10_g7085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000034">
        <property type="entry name" value="Universal minicircle sequence binding protein (UMSBP), putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565">
        <property type="entry name" value="COLD SHOCK DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565:SF20">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7085.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="12175" checksum="A2B3474E9367D421" modified="2023-02-22" version="1">MSSNVCYNCNEAGHISRDCPQPRGGGGGGSRGGGGGNVCYNCNEAGHISRDCPQPRGGGGGGGSRGGGGGGNVCYNCNEPGHFSRECPQGRGGGGGGGSRGGGGECYNCGKSGHFSRECTEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7B8</accession>
    <name>A0A914I7B8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7B8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g742.t1">
        <property type="protein sequence ID" value="Gr19_v10_g742.t1"/>
        <property type="gene ID" value="Gr19_v10_g742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002544">
        <property type="entry name" value="FMRFamid-related_peptide-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01581">
        <property type="entry name" value="FARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g742.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11554" checksum="465FFF8EFAB6BEAD" modified="2023-02-22" version="1">MHIDCFFEVNELGVNEFALNELGSVRANNNFLRFGRAAGGELLVAAEEEPFERDYRHANPNFLRFGLTSAVLSSVRERATVTNCPPPGILSLMPMPIANMDENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7X6</accession>
    <name>A0A914I7X6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7X6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8115.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8115.t1"/>
        <property type="gene ID" value="Gr19_v10_g8115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8115.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18788" checksum="79855C709021FBA7" modified="2023-02-22" version="1">MTRLLHLSVPLNYLIGLRANADYIVQIVPLGMDVRPMWVDPHTTTLVGTKVENDEGEDEDEDDEGEDEDDEGEDEDDEGEGEDEDEDDEGEDEDEDDKGEDEDDEDEDDEGEDEDDEGEGEDEDDEDEDDEGEEKDDEDEDDEVKMKMMKVKMKMMKVKVIGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9H2</accession>
    <name>A0A914I9H2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9H2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8524.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8524.t1"/>
        <property type="gene ID" value="Gr19_v10_g8524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="237"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="306"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8524.t1"/>
        </source>
    </evidence>
    <sequence length="587" mass="65605" checksum="3C64E2E6737383B5" modified="2023-02-22" version="1">MQRTFLSSDSADIIRLHQYCSSLRSCSNRNNSRNEHTLRFVNNLLAELEKSRRHNNELVCRNRQSEQALRQTTNELAATKATAEQLMAENMDLKLKIRRLNQPQQQHQLHQQRTPKKRKSQFPNVDDDDAEEDNHSQSMEAEALRRSVSMPPPDTPLGIVGAAATTNNRSVVAQPAMVVNINGGIKRRRTNNNNKMLAALVKSSRISHSQGDLSIAEDIDELPAVCESPWLFADQVVHSFQTKRNFLQIHCSRCEMTIRFGVLYVKCSRCKSTFHESCRKNAPLPCVIRKNNTPKALGAGSKSGRPRLGDFCPDTRPMVPPLITLCTYFLDRYESFMPYKDLYRVEGDTVQVEAITKQFRHSKGYPKLDIFSPVNVSVSVNKFLFQIREPLIPYSYGKEICALLDRVAADTDGTHKTPEGLPGIVEDLPVAHMDTLGHLCRHWNRLISKSFGLLSIDVLSVSLGPLVFGSVRPDCPLLDHQCANAMAHLLRLGSEEFWVETSVRTMRSGTPISRTPSQRSARSAVVNNATPLPQQPNFGIGTAGAACGGDGEVGKGWAHHQQQPREVDFDVTSGDTSNYESARASHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9H9</accession>
    <name>A0A914I9H9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9H9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7940.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7940.t1"/>
        <property type="gene ID" value="Gr19_v10_g7940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF11">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038115483" evidence="3">
        <location>
            <begin position="25"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7940.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24461" checksum="46C4C5442362A3B4" modified="2023-02-22" version="1">MCRRLLLLYFYCFACIFCQFFARADDETTDEAEKTNKIEPERPNNEAETDEFKDPSGGFGMDIDWVPWPQAVSVALDLNRPIFLLVHKSWCGACQALKKSFSTSSKRKELLELSNKFVMSNTNDEDETEDEEYAPDGRYIPRLFILGGQIWQTLSGGQQKKLPSNIAYFPQVPDVIRAMKMGLELFEKEQSGEKTEEGESDQKKEKEGGKGGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9W4</accession>
    <name>A0A914I9W4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9W4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7958.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7958.t1"/>
        <property type="gene ID" value="Gr19_v10_g7958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7958.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7507" checksum="C877224D1AF2DC11" modified="2023-02-22" version="1">MEPPSPDGDQQVIMARDGRLAAVPTKTPVPSARPTRPPARTVMVLRVVVAIVEHVLPLAKLLQRPLRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Z8</accession>
    <name>A0A914I9Z8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9Z8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8663.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8663.t1"/>
        <property type="gene ID" value="Gr19_v10_g8663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8663.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40655" checksum="17D596A453AA8539" modified="2023-02-22" version="1">MDDYLTVFENQSNGGTKFESVHSRFERLHVSRKDVQWILCDFCGSVVNKLLYENHIVRHEFIDLAYSLHRFELAEEQKRQKLIRRIQEKEKRQQRKNLCVAGFDLEENTNSSVSLSSSSSDESSTSDDDDSSDSTSGTDEFDLSLPGCSTAAVVRPRKRKKVAAAVVKRANTAVVNKKTAVKKKSNRNAMVSSVVVCKVPAVEQQQQPVQKTTAAVATDDLLEVVKMDVVFPPEKFLLPNGHHQPAGVERMQKAEAVGDRHREETEEQRLRKEENRRKRVENKQRRRRNWLEAELMKRHLGPNHHRVFVDNSAALEAYFDRRTGRVSLDSLRSSPPQRRRSRRGVLHEELQCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB59</accession>
    <name>A0A914IB59_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ras family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IB59"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8332.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8332.t2"/>
        <property type="gene ID" value="Gr19_v10_g8332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="11">
        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="10">
        <location>
            <begin position="295"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8332.t2"/>
        </source>
    </evidence>
    <sequence length="365" mass="41221" checksum="C9999012485491B2" modified="2023-02-22" version="1">MRPPNFEQDLISMIRRAKMKFEARTKDDLLIALNNFIDLQPDVVNFVFPDGMPKYCLSFSGTIPILYKGAVYNIPIAIYFLENHPNIGPYCYVKPTPFCSRSSHLNSKINVLSIPSGSGSNPPYPTSGLPYPTVDPPSHVMPQPSYTAMPQPGGYQPPYPNSYPSDPVSYPTSVSPQPESVYPYGTGTIQPTHIRASLLSAVEDRIRQRLRDKIGTPFAELQSVDVNHQELCTGKQILRNMLDSITRDQQELERILEIYTDKKKELEGALKVVNSSGTAANGTSFNVEDAIDAQTIVHRQIFKGHVQDCAIDDTIYHLGTALHRGAINLQMYLKYVRQLSKQQFQHRLLMYKCRERSRLSVWREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBY2</accession>
    <name>A0A914IBY2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBY2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9423.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9423.t2"/>
        <property type="gene ID" value="Gr19_v10_g9423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9423.t2"/>
        </source>
    </evidence>
    <sequence length="233" mass="27182" checksum="D720A53406447A9F" modified="2023-02-22" version="1">MKTVDFQPVVDKADNTLLFRQSLSIFFYSFAAAAVDHPTPAQHLGIFFLLLSSSMTARTRRLDGYVFEKEGRQEKNDVSHVIKEANAVFVEGLHTKLVDKYNKERMKKMDIDLGFFDQWEEQPLFVHKGEVQLVDPNDGDPCTAKWVLNDSKTQYERVSNRTGFIIPLPNRAFTSYEYISPATYLEVLEKDTPADVVLKRTYMPKLCTFEQEIEEEMKLEKRSEEERPPTYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICX4</accession>
    <name>A0A914ICX4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional activator protein Pur-alpha</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PUR DNA-binding protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICX4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8755.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8755.t1"/>
        <property type="gene ID" value="Gr19_v10_g8755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032422">
        <property type="term" value="F:purine-rich negative regulatory element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2450.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006628">
        <property type="entry name" value="PUR-bd_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12611">
        <property type="entry name" value="PUR-TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12611:SF0">
        <property type="entry name" value="PURINE-RICH BINDING PROTEIN-ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04845">
        <property type="entry name" value="PurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00712">
        <property type="entry name" value="PUR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8755.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30419" checksum="F60EA80FB865B43F" modified="2023-02-22" version="1">MPSSSGSEKGIERNGVRGGGEVKRGGEEIASKTLMIQSKRFYLDIKQNDRGRFVKLAEVAMNGRKNRLFMSMRMCKNVKELLEKFEDHVPNLEEANGKSDNATIHSESVVTERRRYYIDLRENRRGAFLRITQGLGQLHDALDEILEEFGEGYLEEDSDLPESQTFRTDGKSFFFDPGHNARGDFLKITELKPSVGVRNTIAISIRAIPQFTQIMSKLYDDFQTLRAGEDVNVTSLVKKESSKEDQLQIDGKEAVDGDQKSEKAADEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICY7</accession>
    <name>A0A914ICY7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICY7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9696.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9696.t1"/>
        <property type="gene ID" value="Gr19_v10_g9696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037955149" evidence="2">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9696.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14292" checksum="D0B71A1FF92A7518" modified="2023-02-22" version="1">MPNSSIKSILFLASILAMLIIEIKMDVPKGNVAKPGGAEPRGLLLLLGGQKTGANGIGKENEQPKSKSKGTALRGGRHKRDVLGNAGGNVGGWDHPIDSSYDYVDTMFKEANWLADKVKKYGWENYGVPAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDD3</accession>
    <name>A0A914IDD3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDD3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8866.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8866.t1"/>
        <property type="gene ID" value="Gr19_v10_g8866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037679411" evidence="13">
        <location>
            <begin position="28"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="115"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="522"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8866.t1"/>
        </source>
    </evidence>
    <sequence length="575" mass="63292" checksum="CBF8D2608BAD26D2" modified="2023-02-22" version="1">MAFPTRRISALMVCRILLLFCIPSSFASSSSSGGPGPSQILERVDHSLFDAWPSTSTPWDTVLSNYSTPSVSTTTAADLAPIRTGPSTSLFHSRPMVALLITALVFVLIVATVLGNLMVCVAIALVRKLKAQPANLLLVSLAFADFCVGLFVMPMAAVYLLEDKWPFGSLLCRFWVTADLILCTASILNLCTISVDRYWAVSRALRYSAIRTRRRICTYIGAVWVGSLVAAVPLELLSFRGNGNVCQVSQNRIYQIVATIIAFWAPALTMVIVYVNLWNAAKKMQRQDRMVLRWQGVQCQRQQNTEPTTPKANGTIRERAENNSSPSLLANANARLMTALRPSSTAQQIQRHHSIEHDKNNNNNNNNNNVTAELDKPRPSACSALAGAIRIPLLGSYSSTASSVVGALTGGVGKSHHIQYEDKARKTLGVMMSVFICCWVPFFILALLKSQRIVHHVPTWLDSLALWLGYSNSMLNPLIYCKYNREFRIPFREMICCRFTTLQDAMRNESYYAKFGSPRSRNGRLNSTASRNGATERSDGRNRHGDDGNGKGRHSLAVGPATADKRNSSPGALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDJ4</accession>
    <name>A0A914IDJ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mediator complex subunit Med12 LCEWAV-domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8907.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8907.t1"/>
        <property type="gene ID" value="Gr19_v10_g8907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021990">
        <property type="entry name" value="Mediator_Med12_LCEWAV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF42">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_90, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12145">
        <property type="entry name" value="Med12-LCEWAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12 LCEWAV-domain" evidence="9">
        <location>
            <begin position="389"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="688"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="738"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1966"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2161"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1971"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2059"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2161"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2196"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2237"/>
            <end position="2256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8907.t1"/>
        </source>
    </evidence>
    <sequence length="2256" mass="257025" checksum="25DE047318D1FCB2" modified="2023-02-22" version="1">MPRANKLTKQEQVAVCCDGDQLDNHIQRIQTRGHLSPDARPLKRSPKSHRQSGGEKGGSSVPITLHADVYPQQEKQEEDNLGPERLARGYQIEVIHRSLVAHEYDTIMKTSNVRFFTNNEQFSKAATLIKQIVQKKNEMNTVFLDKNWLKDNMLRSFKEGIRSEFFESLATGRRLQIKDKRLSLNSSFPKFIRVTIDRLTSLSPQKVSFPLCEAMDLLFEKGVPVQRAIWFFKMNQIAHLLTFPNKPKKGTLVMPCEDYASDQRQFFVRYLRCVLKEFDKAIPGQLEQNIYYQKWPYTVTLIKHSFEDGMLDRHEFVNDLCDLLPEFANFSMEQPQTFRALLILISQFVDVITQNIFIARKVAHVLCVRLNQYRRDYELIRGASTLEVPAGECFEDLTNCHHHRPTLLTMFGMIHAILIDCPSALSKFKPDKSGNSSKLIERESAQNNVAWLCKSPLDQLPCELSVTTQHLAAHAKAQVDQILNIRIEEIKQRSQAIEDRWVHISPSNTRSGLDSIVESCLDILSFLDTVDLGAVDALLVLYNNIFGEDNDCLDITIRVLIYWAVTVEREGSHRGLIIAHLLRMHVHFAQKDGKKLPFGDGFPFLQDLLVDCLNKDWAQPTGKAATNLAFWTAEFANLMLLFYELQRFGLFNHDKYVKALMRDGTLDSRGLFSRLNLNALSVTSGNKSASLSADERANRKPNSLATVQGLPPAQSQPETNVKQEHQMIISFIPMSKPTPPSLNTSVEQQSNNNLSSVQHGGTSQTPKQMEEFAKLPPQFETDNHPFLNESSELSFAERFIVHLPVEQIESNRDVCNQRAIVLYGISEQRDNARQELRKIAREICKAWKKKTFELTTAPHCQPNSVQPEVRYKRRCTPEQLSELMGRFNVQTYYDQLVICGWCAESFLDSVEEFVRQAGELAQEGGAGGTQIVNVSVPAQECLDMLCTMMTICRSINSIITLAQELMPLLIHLRWILKNQLHVDHFSASVSAQYAFVLVSHLAEHFFYLLYSPEACSIINDLYRLVENELGAPIRRKENGEGTGWSRAVAIFVYHARHHLLVSKLNVRGSGPDDIVQLLGRCEEFEAVFPPSGGGSVAANLEYHQQLTDDPSRMSFNDLRNFFNQSYKRLAHSMRNDSVRYSFVIDAFKTAVSCDRNYDRLIELANFCANISANWNLTTEWCNAIQELCYPSASSGDWKELIQDIDATKFSTHYAIATFTLLLASKYCFSTHGLICRLIANVLSPLLSKQEERNENMTMAHRKTDDFGGHDNNFCLTLYICACLCCGTDEPFQYCENNSKSSATSVSVFSRDANKMALRIVHLVELETSIFPLLCVVVQLVDGLKRKVEARKDAVHFRIAQNYLVARCALLSICEQEWVIQRMFCLCDSHDELEMFTNSDRLRNHYVGQQLLRWSLRRKSERSIKQELIEHTGDKKVYERLLSTLSVWNMRATYYDFKLNILEQNPDNQPAKTSNGNQQLASSYQMVMYQQALFNNVANACHLLFKEHLLKGNHCEDLTTVQNFCLTAINCHWLIAPLVNALPSPSPPTTGNPQNTLWCPWNSSAMKAYLLKVVADNLSSTNTERTVQYEQLLGYQPFLNLVLSCTEGEEIKQLLDSLLFYIDDIVKRVKKNAVVPYQNSFFPERDGLILRLNLISGLFDSLLANNNVDLWASAFFQMLYYEIVTDERDRDYFDTCYDMLLMLCFRIYPHKMYTNFIAKFKNLRIPDELYCLQQLLPVAKSQSELSAWGSFKNLINKPIPMAGKGSGGGSTAHFSQQSPITVPNKPKISGIIVDKQTISLQKQMLRVLRHQHWLQKHHSSPKGDLLVSFIPRPGVVGESDISGRNNANLFLAAPEMEQVAALALEEVPSDVLQRQQIQIMQQHQQQQQVVRQQQQQQNTLMVEQQQQQNHHQQMFTQQQQQQIQQPNLMTQMNVVQPPQQQQFSQHQQQMFQPQQQHLVPLHGMLAEGLPGMTTSQQASVRSGSSTPATDSPKTGAGRGGRRKNAAAVSGTNQMQSTGAVVATTGAGRGQKRKKEPKQPQLQQQQSNLGGTEMFRGGQQSGSMIPSQMGGQSSMNQAAMIMQQQQQQQQQMTAQFQQQQQWQQQMQRQQQPMMGNAMMFSAQQQPMPAQAVLPLPTTAAQFRPQQMQTSQQHLQQLHQFPPLHQQQQHQQMRPNHQPQPQFPHPQMMQGMPQPPPAQQQQQQIPQMQHHSQIGGGDQQQQKSNSSNRSVIQQRLMLRVQSQQNQVQQQQHMGMPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF52</accession>
    <name>A0A914IF52_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IF52"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9339.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9339.t1"/>
        <property type="gene ID" value="Gr19_v10_g9339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044247">
        <property type="entry name" value="SPL2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47355">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SPL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47355:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SPL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="370"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9339.t1"/>
        </source>
    </evidence>
    <sequence length="422" mass="49850" checksum="0B8AD4FB2E2A9696" modified="2023-02-22" version="1">MFHVVKVIPPGKYRVIIWDHLITRNDLSVGSAVEEAFPCDIDEIFERRSNPINESSNFEDFCAASQIYFKKNWEPVDSLCRFYKSQCMINYFGSTDRWKISLNNILNQWLSHPLNWEISDKDNFFLLGSFRCLIDVAKKNESHGTRMSSRDAELLSIFLNFLAESNRKQWLWKGLRLADNRIVPMISEFCQIECQLMINIDDKLNNLMACVKFCSQWQDVRDEASKLVQPTVIIETFRRWIYLSSPISLDEQQILYYWIELFAVRTANIDDHWWKWSPFEMDVFREIGNLFVDAKEVFALTFDKIKRFGGIKELLNMICENIKDFSQPNTVYRTTQPFTEQWRSSNCFYGKFRYVPPRHRTSDNLSSMKCVICMTGKRYFAFDPCGHLCVCEECANVVENSAEPNCPICRRRIIKKLRIFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGL0</accession>
    <name>A0A914IGL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IGL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g969.t1">
        <property type="protein sequence ID" value="Gr19_v10_g969.t1"/>
        <property type="gene ID" value="Gr19_v10_g969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF28">
        <property type="entry name" value="E5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044195905" evidence="7">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="76"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g969.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18230" checksum="DCD6B9E28F0E04A2" modified="2023-02-22" version="1">MYKVSSLCVKVLLLFCYCCCCCCCCCFCYNLKTSGPSQIMNVGTAQAGDGGAPPCRPPPSTVMPGPDSGAFCKRKKKRVRTVYSGWQLAALEAQFRVQQYLVGEQRVRFAEQLELNQTQVKVWFQNRRIRFRRDQWATKVQKDTVVNASTATERTGTKQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPJ9</accession>
    <name>A0A914GPJ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPJ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10158.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10158.t1"/>
        <property type="gene ID" value="Gr19_v10_g10158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10158.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="40086" checksum="C34F01FB80B16FF3" modified="2023-02-22" version="1">MSNNASESEQQLQMEKIFICTDIWHGVFAFLNTFELGLKMALISDRLDVLVDVHFKSREWSLGWLRIRRATDGNGAQIVNRSGDRLPIPEGPLPCNVIGFEWIEISYIDQTVVEFLQRFRRLFDSSGTKVWINTGYGQRRSWGIIWQKIWPLVTDNIRCFLSYSPPQFNRLRQFSPAVLRNCPNLRSIHSAGLFPEFPAEDNANASSHQAVAKWLLTPRGDGRPKMLNCDDLYLEEMEGLKRSFVNASEPVNFIIRLRFAGIESFELKNNLTGEQLSLRRFNKDIWLLVRCPIGREEDKWTNWEKEVAQWSWYGQRNCIVIAFRDSDIGDGVVEAEAGPSEPKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQD5</accession>
    <name>A0A914GQD5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 9">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914GQD5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10373.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10373.t1"/>
        <property type="gene ID" value="Gr19_v10_g10373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10373.t1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40247" checksum="E4190A64C6FDB667" modified="2023-02-22" version="1">MASVPTQKEEPFLNQQAREELRAIAKKILQEGKGILAADESTGSIGKRFETIGLENTENNRRRYRQLLFTTPNFGQYISGVILFDETFRQSTDDGVRFVDVIKKTEAVPGIKVDMGVVPLAGTDNEKTTQGFDNLAERCAEYKKGGCDFAKWRCVLNIGPNKPSDVALTENANVLARYARICQQNGLVPIVEPEVLCDGDHSLERCREVTELTLAYTYKALAIQKIFLEGTLLKPNMVTPGNNSNATILPEDVGLATVAALRRAVPDAVPGVVFLSGGQSEIEATRNLNAINRVPGPKPWTLSFSYGRALQSSVIKKWGGKDENMEEAQTMLLHRAKANGDAQRGQYTGEEHAAGATESLFVAKHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSS0</accession>
    <name>A0A914GSS0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10050.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10050.t1"/>
        <property type="gene ID" value="Gr19_v10_g10050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="395"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10050.t1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57336" checksum="63C881FA4A9C5F2A" modified="2023-02-22" version="1">MINHLKTKNHEDALKLFESENTEMTPKLTSVWAQKNAEADLQNKLDEQLVRIMVRQNVSTCFFDDKDLQELVKLAFPGLKIYSRLHFTRSVIPRMAGEIRTNIVKQIGSNNFSITSDGWMKPSKFPALLSVTTHTISDDFQRMDNVIATIEILSEHTGEEIARLIENFLVENGLSIGSIVACVRDDARNMQKSCRLLGIDSFQCSAHMYHLSVRDALRCNSRITNLIAKLSQEQSTASAYIPTAKKILLFLRERRCRNADVQMISENLAENLQVRLAAIESNKILRLSMLVDPRFAFDENFLLGFEWEILEDEFIHLIIREKDSVSTTTVAGASTAEFDDQEFAEVGIDPLDEDSMDIDLWARDVRSPSALSQKSTDSQRELKSAYKAEFNLFRHGIIRLGRDENVFEWWSNNKFRFPLIAVGAKRFLSVPATSVSSERTFSMAGLLYANTLRNRLGAKMAENLMLIKASLKKTMLAPSVEPVDDELDNKEEIEENVLLQQQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTB8</accession>
    <name>A0A914GTB8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTB8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10213.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10213.t1"/>
        <property type="gene ID" value="Gr19_v10_g10213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10213.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22913" checksum="EFEF0D8E67FFFBDE" modified="2023-02-22" version="1">MDAEFKLQDNPKTQMLQIRTKNRWNPEDCHSELFLFKPDLLKVVYRGTKRIYRTVRAEFMLPRNGIGYFEVKIVSFQKGSGNIGVGLVPRSMSLDTWAGRYTDTYGYFDSGKIYGHNTGHFDGFPEFAGGDVIGCGIDWTSQEIIYTKNGERLHTSNLYVLTSDDLFPAVTLENPGDIVEANFGPNFKHNFNDVFSNLASVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTI2</accession>
    <name>A0A914GTI2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="5">eIF3e</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTI2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10610.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10610.t1"/>
        <property type="gene ID" value="Gr19_v10_g10610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="192"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10610.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="48802" checksum="DC152B407E01682C" modified="2023-02-22" version="1">MAEYDLIKRLIPFFDLHLVIPLLEYIEQRKIYDEESFKKSYRRVLEERERLKAACNPAIEILDRDDVKEMTESTTRDREGNNKVLEYIDQRYGFKMEMLDSLYKYGKFLYECGNYLAASTYLDFYRNLIPQYDPNYLNAQYGKLASEILLQSWDHAKDDLNRLRAYVDSEPFASELELLQHRAWILHWALYIYFNCPKGRDEVIDICLNQQPYLNTIQILCPHLLRYVAVSVITSKNKQKASLKDLVKTIEAERCNYQDPVTEFLSCLYIDFDFDAAQTKLRECESVLSNDFFLVGCLDDFRESARLLIFEMFCRIHQCIGLEMLANRLNMDKTDAERWIVNLIRTYRIEGAKIDSQSGQVVMGAKPISIHEQVMENTKRMTFRSQQVALQLEKLRIDSRKGGTWKRGEREIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV33</accession>
    <name>A0A914GV33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11457.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11457.t1"/>
        <property type="gene ID" value="Gr19_v10_g11457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037917506" evidence="2">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11457.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24229" checksum="8AFFFDDCFC68009A" modified="2023-02-22" version="1">MEEFFNLILILFFTTNSLDKAESVKVKLEETPLKTFDELFGEGWWDKGEAADDLKTLPTNFGQNVHHQIDRQNTQLGQIEPNSTDQNPPLTESDHSDNAKNNETVAKELGLSFGTISNWKRELGQTSAPKHKYPHSEQKELMKHYYEIKDQNPKISDENIAKTFKIASRTLCNWKKQFKRQQFHPNSVDGHSVEENAAANVPEIGNSNSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVH6</accession>
    <name>A0A914GVH6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVH6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11162.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11162.t1"/>
        <property type="gene ID" value="Gr19_v10_g11162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11162.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20585" checksum="F40E48196DBA35C2" modified="2023-02-22" version="1">MINHLKTKNHEDALKLFESENAEMTPKLTSVWAQKNAEADLQNKLDEQLVRWKNLKRLAENLEPLSREDFVIIGELCKVLKVFHVETCRLSQEQPTASAYIPTWNFPATSVSSERTFSMAGLLYANTLRNRLGAKMAENLMLIKASLKKTMLAPSVEPDDDELDNKEEIEQNVLLQQQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVU0</accession>
    <name>A0A914GVU0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVU0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11658.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11658.t1"/>
        <property type="gene ID" value="Gr19_v10_g11658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054174" evidence="1">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11658.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18455" checksum="FDEA3C349D3F62B8" modified="2023-02-22" version="1">MHPMFCFVVLTAIVDIDGQLLENVKPKKDEDELDADDKRAVEALRKAIDEYKQEPKILVEVLDVANCRKTVKAYCPCGWAKCIRTSKFSFTNELTKCCPVDYDVKCCVTFEECTDYCIQDYDKQWGAKSSYPDLCSRACRRKKAFPERRTAIQCLYGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW30</accession>
    <name>A0A914GW30_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein smoothened</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW30"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11298.t3">
        <property type="protein sequence ID" value="Gr19_v10_g11298.t3"/>
        <property type="gene ID" value="Gr19_v10_g11298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11298.t3"/>
        </source>
    </evidence>
    <sequence length="921" mass="104497" checksum="C486AEFD98A68566" modified="2023-02-22" version="1">MPPPHTEYFAYEKDRRVWNSITLQYRFIYEAVLPTMAESVFFTCFLLLCLHLAVATGYPIDSHDSDIEEGNAQQRKAYRGMEPSEHAQVAKTLQRIKQDNVWWLHNSCMQGRGYTNDSGCTDKKPDKCFGIDISYKNRVEIDEGFPHWIEFLRNFPRCWRFIAPLVCVVHYRPCTHLEMNEQHKYVGFELFPAQLCKEMRLHCDCDARVRGAQKQDDCNLNFYSRKEPVQLMDQAKACLTPLVYVNTIEEAQRIHALPLVDECFIPCSSTIYGTQSLSTLNMFTFLCFFVVLMLALLVLLRGRLVCDFGMFICLLATVSTLFIALTFALSPFFGDDVVCLLNGKIRRYFGAFTLANGNDILCFLEATYLKLFLIFAFWASFIIVCNGFVAKSHNRFLLLQQITALCHLLVSSFITFIYREISIDPVSKVCHYFRFRTVWLNLADFLLVLLVAFFIFKLSKRKSLQRQLDFYGQLLTETEQNPSSLIGFSGKSCADTEHCGAEMGGRLPFWQRLFDELIRWIHPLFLLIVYFGCVLSFYMLTEKTDNESDLLTSQINCSLSALSTDKWKGAGHLKSCQIVPQSPLWYYANSLVMSFNLVLMLAVILGSMNCHKSDKSVTNGEEETEDDDKNEVELDIFTPTSENGTSEQRRNGLGLNYNNRSSVADSIGEQSSNGYAEIDCTAFALTNTAQRGRGKRQSGRKRRLNSLDRSNKARRKRELLMAGKNEADDPMLVQATDTSSVSESASTLYARRHQVSNLETLAPSSPVDGVAYSPCSPSQPHAVPAAFSSTPLIVVHWLHQYCPSGGLYHHQSDHQQEAEPERADFTTEKANEEEEESGEAGRGANTDAQNPYKVEEADEKSKDDEGNAEGDAESEYPISDEEEADDRDSNDFCSDSPDSIEELFWNESCQKAAQHQQPAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX08</accession>
    <name>A0A914GX08_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GX08"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1213.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1213.t1"/>
        <property type="gene ID" value="Gr19_v10_g1213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1213.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24210" checksum="A0426B90B000948B" modified="2023-02-22" version="1">MFFRLHQFRRCRLKRRSQSLMVNKLNHFLLGCATNQDMAGGVYCNTRNVFDWSDSTASFVNYAYDLFKMANASYLTQQRNRKLTLAHQWTVRHEPLATIPVEPSSYAQQRKFELALSRNGTSTNCRGSAMKNRKCSSFCNSFVCLRFPPTDGGPANFAPTVDDPSPTVNPFTSSRANPHGLASRCADLRRVVAAHVAIYRQLICETLSEEGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXW3</accession>
    <name>A0A914GXW3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXW3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12203.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12203.t1"/>
        <property type="gene ID" value="Gr19_v10_g12203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35245">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35245:SF2">
        <property type="entry name" value="DISINTEGRIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12203.t1"/>
        </source>
    </evidence>
    <sequence length="435" mass="50249" checksum="0FCE6050507876A4" modified="2023-02-22" version="1">MAALPAVARASLTRTPLAAHLQRVRTAQRCSIGVPDPRFSKNRCAEAEAQSRAEAEAQRRAEVEAQRRAEVEAQRRSEAALRPTEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAEVEAQRRAFEKLGKIATSTRRSRRSGMNTADNERMKTDAAVMPEDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY12</accession>
    <name>A0A914GY12_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GY12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12382.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12382.t1"/>
        <property type="gene ID" value="Gr19_v10_g12382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF7">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036884700" evidence="10">
        <location>
            <begin position="26"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="11">
        <location>
            <begin position="40"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12382.t1"/>
        </source>
    </evidence>
    <sequence length="478" mass="52564" checksum="83D13119B723C516" modified="2023-02-22" version="1">MRQNYRRSAFVAALLFALLNQSSDGAFELDNALLGQPNISCHPDTIEMRFRTKRPFTGKIYVQGHYANPDCRVDFSEAGGADHDGRGGIRLHHGSCDMDRKRMVSPSGGTGMEFSTVLVISFHPLFVTKTDRAFHINCLYKEADRNVDAKMDVGDVTPANIQNDMPIPQCHYSIRKDELNGEVLKFARVGDLIVHRWECESDQFGMLVHSCFVEDVQGERVPVIDERGCHKDQNLLGDPTYSEALNLAYRESYVFKFRDRVGVRFSCEIKLCMKAEDGCSDITPPNCQDSKGYQEHYQHSRDDPLGVGGGNQSKTATAASNINKRTRRSIKTVDADLISQYVFVLDEPVEGEDEGEEDANIGTSNAAVPVKLRSRVAKDRALLAGSPVCVSPALFAAIVIVVLASFGLASAIVGHRLFQLSRNGGIFCDAAKHSAPSAATLSNPSVLSSPFSSRSSIGSSSFNPSMIRMPQSLLFNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYD3</accession>
    <name>A0A914GYD3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYD3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11526.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11526.t1"/>
        <property type="gene ID" value="Gr19_v10_g11526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11526.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8290" checksum="7A20F6BFEA55AE9E" modified="2023-02-22" version="1">MSNGVRQLPIPLELLPDNVIGFRNLRIYYIDQSVIEFLQRIRRLFDSTETKLSIFMEVDLNGNWEMIFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYS6</accession>
    <name>A0A914GYS6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYS6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12036.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12036.t1"/>
        <property type="gene ID" value="Gr19_v10_g12036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12036.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7575" checksum="892D314F56030BC5" modified="2023-02-22" version="1">MCLSFSSGDVRFVGFCEWNKQAKVRWVARLIKGAREKQSVESLMRRHGGAGVGEAEGDEQMSRLNATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ30</accession>
    <name>A0A914GZ30_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZ30"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12442.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12442.t1"/>
        <property type="gene ID" value="Gr19_v10_g12442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12442.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22272" checksum="CB1175D7B999E260" modified="2023-02-22" version="1">MTLRNDTPMPEDSELKVPHEISLSSPWLKAVAVYMGIACEKEAKEFMLLRGERGNDPRKSLVEGRQLTACAINFLREMRRSCGDEIRAYANCFHVESENMFPNQCRRDQYPMDICADEKLGIRRPPAGYFSKLHVHESAVPPPDPAAAKLAMYRDYKAEAAKVFDELPEDWKTDPEQFKKYRNMAFYEVFNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZK0</accession>
    <name>A0A914GZK0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914GZK0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12649.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12649.t1"/>
        <property type="gene ID" value="Gr19_v10_g12649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="11">
        <location>
            <begin position="310"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="531"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12649.t1"/>
        </source>
    </evidence>
    <sequence length="904" mass="102287" checksum="5046F10ED8AA1F9D" modified="2023-02-22" version="1">MKKNVDHFGINCTQIDFANDIAQFMLSISVTSLYDLACANFQKEYDPKNYSEEVAKQDQVDACAQVPTASFCNETLALYACYQTESKMSAVNMEIAQICQNHLGISMVAGFRTRICVHREAEKELIVVESILDFSFSDQSYNIKRNFSFKIGEITNAMEYMEYAPIFFIQFGNKHQKSVVREEANGKAISDDLDKEKATIGARHPSPCDVLGDDCELVKEIERKIADLLECCSPTNPGGPCICTLPTPDPKEFTVFPPSAIIKPVNTQNRKPDKVLHTKEQAQQIYEGYMEKCANCTPFLKKESHRAKRQALPDFNKWTTFPIVIKFSETLGINPVAWKDAIDKGTRFIAKDTCINFTTDLSHAADEGIEVVDIFDGTCGGSYVGKTEKWHQLWINCTNGGVVAHELLHALGLKHEHQRDDARSYVKLNRAKITKDWIEWYEPLPKTNNYDFPYDVGSIMHYPSGCNSEGICTIITLNRFYQQTMAHLEKPSFKDLALINLIYCKDNCNGTENKCQNGGYPHPRRCSECLCPGGFGGTHCELLEEDSYCMDFSGFGGYPKELVADWQTREFKPELSCGGDALSCSCHWRIKPKDGKKVRIHLKMLNETLKCEDPCKQAYVEVKYRKDKRASGARICCSDLIRLQTDFTKNWIETDGPDVDIIISAHIKTRDKINLFELTYETDGVKLVSSSDCPEGANYDTKRDPEYDLICDRDPLTGEGILCCPEGQVCPKKRVSHSTWGCDIVVLNGQYREIRGQNESKSFHFECFRREGESASFWGYWKDKSKDPIRIDDFQCLFYEEAGINQPPNQTVIDYPIEFKNEAYNTADSQDVSVPSTKPTLFSSTRRLLLSSLSAHSSSALSINSLPIFTFSMTQKFHPRGTLRTKDAIANPNNYVTTIIDQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZV5</accession>
    <name>A0A914GZV5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZV5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12735.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12735.t1"/>
        <property type="gene ID" value="Gr19_v10_g12735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12735.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25626" checksum="F9923F18161C8019" modified="2023-02-22" version="1">MSDNSKEVEKQLDEISICADLLFGLRILWPFCVPTESCVDQRSLIVWWTRISNQRNVKIVCGEVERRLPIPQEPSGQCDRIQNPSNKASFGDQSPFTRKMTKTAVGKSFGTEFPLIRDKICGFLFGPFEVDRSPFLSDRSRRLPQTSNDPFHMFFPEFPADDSAGTSSGQVGQMVAHAPRGWTSERVANLSIRPLRPIFIRIWNNSSAVVVPFQLMNNDGGAIGVALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H092</accession>
    <name>A0A914H092_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H092"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12039.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12039.t1"/>
        <property type="gene ID" value="Gr19_v10_g12039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12039.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16160" checksum="20180FB22EABA81A" modified="2023-02-22" version="1">MLQNIERLRNDQLGTELGAWLNTGGGGGVKTLDEESYAVVGRAHQTSDFTERSDTPQFPVSERTETPMPYHPLLYRRDSPTEDAIMLKQSHSGKSQTTTTGSSNRINSNNIYSNHTNNRIGAITPHGMYGNGTPVGFNRRSSLTSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0G3</accession>
    <name>A0A914H0G3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914H0G3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12093.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12093.t1"/>
        <property type="gene ID" value="Gr19_v10_g12093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF11">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="5">
        <location>
            <begin position="192"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12093.t1"/>
        </source>
    </evidence>
    <sequence length="624" mass="71999" checksum="465915F4D4755583" modified="2023-02-22" version="1">MEFFFEFLNDLKLLLIAIRKSNLEDGNCLRVLLPQGGQGCPFASVAKASKLHSQSAQMGRLQSELIDVSIKMETLRNSESECQSQLANLQQKFSVPSNGVLFRNRGRLPLFVNGAQQQKNARRVPVQTDVYPLLTPEGNFVPSKLWVHFDLKGAPFKVTYFIELLRFVRKMGINGVLIEWEEMFPYKGRLASAVNGNAYSLEEIELVLTEAKLIGLEVVPLVQTFGHLEWVLKLEQFAHLREDPQFPQVICIGASEAFELIKEMIVQVAEVHGRFGMKHFHMGADEVFQLGVCNESIREISNQDGRERTILWHISRVASFIKETFSVTVLAWHDMLVQMTERDLMDYEMTDKLEPVLWSYAEDLNMYLPFSNWMALKPFKNVWGASAFKGADGPMRFHSNPIHYVRNHESWTDQMTRVYSEFDRFQGLIITGWSRYDHLAILCELFPVGIPTLSMSIETITMGRPLNGMYDKTKELLQCQPPVMPGYITGCQFPGKKIYELVNECFYELGQFRKYFDADFDLNGWASVLAERETFSSPFYIEKVLPNIYMHLSILERIEHDLREELHKYFFAELADEFVLTYMGAQLETLRARKAMGQRILKTKTFARRPFVKYPPVGTKDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0Q6</accession>
    <name>A0A914H0Q6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0Q6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12969.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12969.t1"/>
        <property type="gene ID" value="Gr19_v10_g12969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF222">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12969.t1"/>
        </source>
    </evidence>
    <sequence length="710" mass="81259" checksum="8156689E81B72A1B" modified="2023-02-22" version="1">MSAKPFQTFKPPKIVVLDEQNERISSSNGSVSSRQSSKDSMEPPAEFGNNSAPLKNSDSIGRANGQCIGSNKSKLIKSRASELIIRIPSRHLKRIMRTQGIKSLQRETQHFVVYRSRGAFRFFWITVTTVSLVLLLWQITKLVQLYFSRPTASQISFLLNDNGLPFPAVTICSHQPISQQFVENSIKAMNISQRLLEYIMLSFVDVQHLLSVSDQDELAFADEEWKEFTHLLAPKFTLCSFGGREFDCCEYAKGILTDIGKCYQLDLSSTDQPWLRGQVQAGINNGLQIIVDARTEQQTNSLFLDTAHPFADSLDTGFRYYVHEQFSLPYLSTEGISVSPGTKAYSAISPTHYILLPQQMWGNCSDRWPEDLQQIVNDGAADDRYSSVKCKTLCRSKYFNDLCGCSPFSYNVDEFYSVCTPYEIYKCLNSTVLNDTKWFQNGMAKPGLEDFHQIIPVCPQCKIECQRWVYHTYNSYAQAFPHKTFGRLRRKASKWSSIVSLNIFYRDMAYTEYKQVQSLSMTEILSDIGGNMGLFLGMSLISLIEFVTYICKISWLFISKKRRDHMLAKKRHDEEREQQLQQTLEMTNSRANDLPTSQFDTIIRRISRSIQRKPARAEKSAVFILPVSGQRQNSESDDIPSSTKLSRPANSLKSCPTLHENAIWLIQSLKVACTEMPAGHQDEAVLHHQKHYLQQNEKRWSLKLTWSQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1V6</accession>
    <name>A0A914H1V6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1V6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12462.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12462.t1"/>
        <property type="gene ID" value="Gr19_v10_g12462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000002">
        <property type="entry name" value="calpain-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF419">
        <property type="entry name" value="CALPAIN CLP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="274"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12462.t1"/>
        </source>
    </evidence>
    <sequence length="739" mass="78895" checksum="CF17D95D78E4DD8F" modified="2023-02-22" version="1">MPPTVDDDFRKVEIRPNEFGGLIGNFAGGMVRNKIGGPAGDFLGGLLSGGGGSSGFGGQGGGGPGSGGGGGGFGNLIGDFIGGGGGGGGGGGRRAGGDGSSGAGGGGGGGFNFGDIAGVIGGLAGGGGGGGGSGGGGGGFGDILGGLVGGGGDRGKYSGGGANINQNFLSGGVCDMIGNLIGEAAHRFLGVNPQTGKIIGAIAGNALFNLGGKDNKLGNIGKIILDNIISGKFHRDVDPFVKPEPMPTPGPPIRRKEPVNFYDERDRCLQEKRLYEDVDFPASDQSLFFSRRPPESVQWLRPGEIVREPQLITEGHSRFDVIQGKLGDCWLMAAAANLTLRDELFYRVVPPDQSFTENYAGIFHFQFWQYGRWVDVVVDDRLPCSLEGELLYMHSRELNEFWSALLEKAYAKLYGSYEALKGGTTSEALEDMTGGLTEFFDLQQPPENLMQMMARGFEMGSLFGCSIEADPKVWEARLPNGLVKGHAYSITGMRMVPTPRGEVPLLRVRNPWGNEQEWNGAWSDNSSEWSQLSNELKTDMGLTFAHDGEFWMSFRDFLANFEKMEICNLGPEVMEEIYEMTGVKATPHNTWATIAHDGSWRAGKTAGGCRNNLRSFAQNPQFRMKLTDSDPNDDDQLCTVIIAVMQKYRRELKNAGIENLAIGFAVYEAGGGGRLGTEHFANTKSCARSPAFINLREVTGRFRMPPGDYVVVPSTYEPDEEGDFMLRIFTNGFVESAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4E7</accession>
    <name>A0A914H4E7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4E7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13889.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13889.t1"/>
        <property type="gene ID" value="Gr19_v10_g13889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13889.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9004" checksum="7622FDBB5373F875" modified="2023-02-22" version="1">MFTARIDGRGAAAEAAEAAEAAAAAVAGVGKYANRASRRRQPSGQPIFAAGDGCQQQYHQKQQQQKQAAHETKKKQHVETAGAGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4J4</accession>
    <name>A0A914H4J4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H4J4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13923.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13923.t1"/>
        <property type="gene ID" value="Gr19_v10_g13923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01012">
        <property type="entry name" value="YcaC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF17">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13923.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20222" checksum="400B119C6AF7D416" modified="2023-02-22" version="1">MQEKFREHIKYFPQIVQVTCRLIEAAKLLDLKILATEQNPKGLGHTVPEIDLKKHGIPVFEKTKFSMCVPDLQRQLGDAPSPIRSLLLCGIEAHVCVYQTAVDFQQQGFSVHVVVDGSSSRSMVDRIYAYKQLERAGINLITSECAILGLVGDSAHPQFRAVQKLIRESAPDTGLISHTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4L5</accession>
    <name>A0A914H4L5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4L5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13194.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13194.t1"/>
        <property type="gene ID" value="Gr19_v10_g13194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="725"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13194.t1"/>
        </source>
    </evidence>
    <sequence length="764" mass="87827" checksum="E00138848CE44755" modified="2023-02-22" version="1">MDKISQIMHLFRPNNTRENLCALNESIFDSDLRLLLVGIVGSFVSIASIVQNTLLFYVFSTSRKLRRQNYVNPVLLAFFDIFVSFVYLLISPVHFVAHRLRSPFLATFWAWNHFALTVCNLLLVVASLERFLANGPLHSQKKVLVLIVRNKPYVIVAILAFAFVLKATLYFEIELLPLPNCSTNVTDISSVVPVWMTDSGGLFQMFRFWVRNILTQLRRRRRMTLGEYSESVISQTNANFENAENGSDRMMRRRTTAESQLSPKTLIITQQNNERNPKLRLVLKGTTSNCSGMLEPTAIARNIQKEPRNTHLLMQNDFDNKKLERIRTNCCATNSEQSPKATAKAIESKPSSTTTATASIPNNNFGVRVATRTLLMVVGCYLISNSMSTFLNIWEFFDSQFLRHKNLCVYLTASDVAALLTIWGCALRLPIYVCNDRRIRKAICRAIIRFRFCCSKSKPEEIVRGEEAEHFLEKYSIVIVSNSLRSNLTGVLSQYDWGTFQGKRSFDQLAILVQNRQKFLVQMTINLGAATRPTPNDRQRDKKMFGRRWIWHSSKPTNHLEWAPPMRIIAVITLLASTLDLMADFLLCSRLAEYLHNFQTDIARYCAYGFFFFTGVSILVYIFEMVDVCLTLKYDEENVYFARLAKSMVLVLEEVPLPALLYFLFTSEPRLSIANPMHIASWIKLITLSWGIIKFAKLRFFWPLLPFNPKHNRRENIRRCFHLNLYRLTMIVVNLFHFMAISIVITNLVVSGRGGRPIHVQGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8D5</accession>
    <name>A0A914H8D5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8D5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14679.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14679.t1"/>
        <property type="gene ID" value="Gr19_v10_g14679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14679.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20335" checksum="6492F370E4D284EE" modified="2023-02-22" version="1">MARPPPDTDFMDPAPENIQQGGWSARHYKQSPAIVYVEAFAVVADIVKHGNCWQALKRRHENAPFTVGLMDVWDFGALALFHALGIKNVVLIHNFPIMSHMYDYMDEAKWPNAEGQTLNYKKQILKNEVFAATVNNDSKIGKSDAFKAEHSASSLIFTTIYEQMTRSPKRCSKMTIFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8M4</accession>
    <name>A0A914H8M4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914H8M4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14248.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14248.t1"/>
        <property type="gene ID" value="Gr19_v10_g14248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="202"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14248.t1"/>
        </source>
    </evidence>
    <sequence length="751" mass="86285" checksum="02299BE5910C426B" modified="2023-02-22" version="1">MAYSNGIKSDGKFYYFAYGSNLLKERIQVQIKEAEFVAIGVLDNYELAFFDHYDRWHSAVATIEEKIGSSVWGCIWSVPNSFAQELDNQEYCYDKIKVFVQPRLSTIGHFNSQLTGSAPIECHTYQYSNPDRKQDLPSPQYKYVIVTGAEEHGLPAEYIEWLRNNFPDNGYNGTVEVELKALANMPKPPQKIDTESDGKFYYFAYGSNLLEERIQVQIKEAEFVAIGVLDNYELAFFDHYDRWHSAVATIEEKIGSSVWGCIWSVPNSFAQELDNQEYCYDKIKVFVQPRLSTIGHFNSQLTGSAPIECHTYQYSNPDRKQDLPSPQYKYVIVTGAEEHGLPAEYIEWLRNNFPDNGYNGTVEVELKALANMPKPPQKIDTESDGKFYYFAYGSNLLEERIQVQIKEAEFVAIGVLDNYELAFFDHYDRWHSAVATIEEKIGSSVWGCIWSVPNSFAQELDNQEYFFVQPRLSTIGHFNSQLTGSAPIECHTYQYSNPDRKQDLPSPQYKYVIVTGAEEHGLPAEYIEWLRNNFPDNGYNGTVEVELKALANMPKPPQKIDTESDGKFYYFAYGSNLLEERIQVQIKEAEFVAIGVLDNYELAFFDHYDRWHSAVATIEEKIGSSVWGCIWSVPNSFAQELDNQEYFFVQPRLSTIGHFNSQLTGSAPIECHTYQYSNPDRKQDLPSPQYKYVIVTGAEEHGLPAEYIEWLRNNFPDNEYNGTVEVALKALEKMPKPPQKMQTDLDRTEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9F1</accession>
    <name>A0A914H9F1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H9F1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g150.t1">
        <property type="protein sequence ID" value="Gr19_v10_g150.t1"/>
        <property type="gene ID" value="Gr19_v10_g150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g150.t1"/>
        </source>
    </evidence>
    <sequence length="905" mass="100935" checksum="5D6598A302C11373" modified="2023-02-22" version="1">MNGPSGNDTRPSANDTRSVFTATNPLKRRVSFRDMPNIHEYEHASSTSTPTPSPLPSGFLDQTRTIFNAFELAQQHNQQQQRPKFKASLSSLAPMPSPMPPGFLDKTRTIFTSLEPVQQHNNQQQQQMPQQQQLQNVFKFDDADDSSLSLTKSLRLPSTPSHSSADAEGMDMEEVNAMTVAQTPTKLLMIDKVDNYGAINEQMNHTHVIQHTPFHDRLLSLTTTNTEVVMLNELTKRHGGSSLLFGSQEGYGLDNLSAVNQTMNIDEEQKQIFLASKTEEALVGDDLDDLFAAEQSISMDAQQHQEQQPQKGHDGLDELSVAAQSMSIICSDVQQQQQTNKSGAAADGRPSSSLSAAAVTLLTETPKSSHHTTTTKTVAAVVAVVAEPETPPPPLPMGHLSDADFEQWHDMEMERAMEHYCEAVQHYTDLYKPYYDEQKRVLDQIDRVKERIGKFRAEFGAAEQQHGERRRALLRSNRPRALSRCAAEQQTQHINYYTSPTAPPAAAAAGEAPPAAAAHRKEMFDDENPFTLVTFVGRIGLGLLYVKVLQSLFNILYPYLVGRPRNLRELAGENAGWAVVTGATDGIGKAYARELAQRGFDLVLISRSADKLETVATELKQYSRESSGHREVQVRTIQFDFTNAKLADYEQHIFAQLNDINVGILVNNVGMSNANDYPERFDKMPMKFLSDLTVLTLHIKFCMHFSIVNTLPVTVLSAFVLRQMVKRGGRGVVVNVSSASAYIKWYQYAVYSATKKYIAHLSDILRKEFAADHPNIVIQTVCPMLVATKLTQRTSRDGLSLLSAGPAEFARQAIRTIGLVAETSGCLIHQIQVELLFNFLLMFIPTPVFDFFVRLEAHLHKNRLSSTIFITMLLLNFGSANVPFVDGKKTNDKYDCQNDRILKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAG7</accession>
    <name>A0A914HAG7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAG7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15556.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15556.t1"/>
        <property type="gene ID" value="Gr19_v10_g15556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023339">
        <property type="entry name" value="CVC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052294">
        <property type="entry name" value="VSX_homeobox_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46892">
        <property type="entry name" value="VISUAL SYSTEM HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46892:SF3">
        <property type="entry name" value="VISUAL SYSTEM HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51496">
        <property type="entry name" value="CVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="229"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="CVC" evidence="13">
        <location>
            <begin position="291"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="231"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15556.t1"/>
        </source>
    </evidence>
    <sequence length="467" mass="51409" checksum="D758EC0EC20B9E51" modified="2023-02-22" version="1">MHSNQHNETEEQLPAVVNDSASLMQHDPRYMLNSYGIGRTNFAINEILGLASAATMPQITALSNGGPVTNGSFANYFMTPASYCPPAAVLGSASFMDQSAVLGNVTGAANCPASQSVLSGLEFMPMLQFQQDYADYSFISSGSGGANSGNSREMSKSLLNEICHHQQQQNNCRNNSNNNNNTAQNMAELVMAAKASAAVTTDNGARRHNNGPPPPPPPNNPTKSPSGKKKKRRHRTIFTQAQIDELELVFQVARYPDVPQREQLANKTELAEDRIQVWFQNRRAKWRKTTNSWGKSTIMAEYGLYGAMVRHQLPLPDTITKCVGNFEDSQGSAAPWLLGMHKKSIEAAAQLDQIEDYKEGDDDDEIAEELKAMVVSHGAAKCRTTLLMEHLSEDEKYPKEQQHQRTVAAAGGGQHEKKRRQHGKCGSNKGTSSYNNNNNNNNSSFSLQMQMEANNAQYLSRFMMGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAS3</accession>
    <name>A0A914HAS3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAS3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15359.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15359.t1"/>
        <property type="gene ID" value="Gr19_v10_g15359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="45"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15359.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32768" checksum="A847E658631163FB" modified="2023-02-22" version="1">MANSGSASNVNDSQIKRRRRLPLELQCEVISALPFHHGSRMLLLCHPIATNCVSLVRKQKQKFENRWDPTACHGGLRIIEPKRLLVRYNGKNREWSSVQAKRPIPKGKFGIFYYEVTILEKGAYFVHIGIGAKPMPLDVWVGGYEGSYAYGSCGILWGHEVEGCFYSNGRPFINVEPRFEEGDVIGCGVDLATRQIIYTKNGQRLETTGLYVSDSATELFPCVTLHGYDHKIEANFGPNFEDKWLFVRCPIERDEDKWAELEKEAAEWNWCPWNCLDINFQDSDIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAV4</accession>
    <name>A0A914HAV4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myoblast determination protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAV4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15666.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15666.t1"/>
        <property type="gene ID" value="Gr19_v10_g15666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19699">
        <property type="entry name" value="bHLH_TS_dMYOD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000005">
        <property type="entry name" value="Myogenic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039704">
        <property type="entry name" value="Myogenic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534">
        <property type="entry name" value="MYOGENIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534:SF9">
        <property type="entry name" value="MYOGENIC-DETERMINATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15666.t1"/>
        </source>
    </evidence>
    <sequence length="683" mass="74323" checksum="AD4369E72135F32A" modified="2023-02-22" version="1">MSMKAMGMGVTPDYDPLYGYALSRPSSLGAAQRAVASAALAVDEHHQQQQLATLTAFSVSSAATNSPMDYTVSANLGPPAYEQLQLCYSANGYYTAAGAVAPLPSNGGVWGAAGGGNAYHQLTGTTDFCSQPQQLHQQHNPLCTFATATPTVLLSSALQQQQQPQQLQHHHQTQQQQQQQQQQQQMAQQQQQQQSRSSPSAVPDFVHTLQVASQQPPAPPQHLTELIPAHQQQHALIHQQTQQNRRGRGTGANALNRTVKTEMKQDQQHLIAAGAQPSHPPAQKRRLPNASKNASTKTASASTAAAPPSDPFGAANSAFGTSAGNAPPATQMPPTKKTKYSVERRKAATMRERRRLRKVNDAFEVVKGRTCPNPNQRLPKVEILRGAIDYIGLLESLLHTHAKIGPILAVAVQQQLQQQHIEGGEEEALECETDIEGRVQLKNFPAIVHGYYKHRALYCVTPTPAMLDQLHQPGCCGMEEHHNLEHQQHLHHPHQMDDELEVADVFFHHHHHQHPMSPHHILPDQLTLVPQNAPQHAAPVNVAAPKGHKQSKNRGGGGGTIGRPPGSGKGGAGGAGRGRGNGQNRQIAGGQNANNGEPVPLQLEEHVHVAIQKSPQEMFGGGEMMPDEKREGKEEEEEKRKEEERQQEEMDVQRQEHEDGAVQAQAEDEKEGTAQPTLMGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBF6</accession>
    <name>A0A914HBF6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15530.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15530.t1"/>
        <property type="gene ID" value="Gr19_v10_g15530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15530.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33705" checksum="A4D27A229CF25210" modified="2023-02-22" version="1">MSFFNGFIRLLHALCEAVYYWWIGALKAIPILHIFPRKSLKGQIVLITGSGSGIGRLMAIKFGKLGSKIVLWDVNERLNAETKMALDELDIESFAYTIDLSDRKAIYAVAERVKQEVGDPDVLVNNAGIVSGRKLFDCPDELMEKTMAVNCTSMFFTVKAFLPAMIEQRRGHIVNVASLAGVAGINGLADYCASKFGTVGFSEALRLELIELGVPITVTTVCTYYINTGMFDGVRSYSCLFPILNPDYVVQRIVHAVLIDADELFLPWTANVVATFKGFMPARAVYAIAGFFGFNRTMETYTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCD0</accession>
    <name>A0A914HCD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15805.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15805.t1"/>
        <property type="gene ID" value="Gr19_v10_g15805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15805.t1"/>
        </source>
    </evidence>
    <sequence length="1145" mass="130484" checksum="243E6AF70D51688E" modified="2023-02-22" version="1">MARFVDQNLPRSPKNAANCGPRASPGTNSAKTLNLWGKVIFELLSSYLMRKKKQITRRMPLICQICSQFDDECNQIDVPSWLTTTKSEVFDDSSQLRSHLIEEHSKFVAESLLAPNIHDKTHVWLLANVDYSANAAQMVQQENVGESENNGHQQDTGIQQQQDEDDVAQNGLDYNNGGDPIEVLLNGIFGGNGSVAVAELEEPSTSGETQQFPITIGQGEENEKLDFFGTALKSFLLSVSAESPLSDDSTTTNAPPSSCRASMVDSKAIRKAHCQVCKLDICSTARQRHVYMVHLKKKDLFKCPRCEYTNSNSVWEVQKHSRVQHGKDARPISQEEKHKLEIQMWSQLCFPEWKQKRKIDGDSVEEETTMKRRKESEDGGTEVDDLLEGFGELLGHLLQQSEDNSPMGGENVGEEEAVIVQEGQEDEWQHSEGRDNDNASPSSTNQQTTPIDDCAGGNDRLCHLCMEESKYPGRHIAQRHLKRPLYECPICCKFGSYESCTVSKHIHKVHPKEAKNTVPISNLDKYADEIRELQTRCFPNRQMKLVRPANNSGKARPRERHQCGVCSADVAQSDRQRHVFHKHLRKGKIFECPLCDFSSNYDIHRVKWHIKWDHKEFVDVAGGAQFEPISHESLYRDEIDALNDKCFPGWQRKRHLNAGDAGERKSETPTTKSSDEQRPEDWGAKILGEEVMTKNGHDVGEEGEPTVKKSTLDDLLMEMVGSHQHYSWGDSPGTDEKARSLAELDGAANALEWTCQICHTALKPGTNLLRHVAKDHLNLPLYQCPICENHGAHSAYEVRSHMLRTHADTTQEPLSSLEENLGEIELIYRRCFPRKEFKAGGGGGDRCSQETSVARQTTIDEARVRCRECGQEMKTEDRQIHVYRHHLREPRLYECPACDFSHYACSSDVRNHILRAHKNQTELMPRANLLRYSRQIAEWNERCFPGWINRRLPASVTEDFNSCRLCGMDVRQTSRHIAEHHLHIPLHQCPLCEYGAAEARLVQRHMRNNHTLKECEGLEPIANVEKHRGEFSELHNQCFPGRPKRLSNITIADESRRAKCRGCAQTISKKRRLLHLLEKHLKKPIYKCKYCLFTSTHDKMTVEAHQKEKHFGKTPHVLTTLSRHKVELKRMATECFNEPELKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCV8</accession>
    <name>A0A914HCV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16341.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16341.t1"/>
        <property type="gene ID" value="Gr19_v10_g16341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16341.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26177" checksum="B4D9204E8E7A4F9F" modified="2023-02-22" version="1">MRKIFKEIQYFKRFFPKFLKKNAIKTTKFNDEFEGFPAKFTGFVIIGSYTNRRHCGSTPAAEKNPLSICLIKSCRLIQIFAICHRKFVISSTRGLTLSADVRPNHVVWSYGKRYRYIIYKIVDKEVIVEVAVSSDDIGSAGDESYDDNSKAAYESFVKDLKERTEDAASRCRHIQDGQNCLHPALPGWCFNQEENALRIILQFQVSDESEIAHKELLGKLNDKYRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCX7</accession>
    <name>A0A914HCX7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase B subunit 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCX7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15964.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15964.t1"/>
        <property type="gene ID" value="Gr19_v10_g15964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000073">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15964.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19127" checksum="E6434FBF1A0993AD" modified="2023-02-22" version="1">MRCIVVKHLFLHVGFSMNSLYFEDLFTVKNIDPEGKKFDRVSRLFCDSESFKMDLILDVNTQLYSLGINDKFRLMLCTSIRDDGLTEEGEYDKSIENIPRVRMFEYVMYGKIYLIENDEGSAETSRLTAYASFGGLLMRIQGEANNLNGFEQDKNIYLLLKKVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE50</accession>
    <name>A0A914HE50_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE50"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16301.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16301.t1"/>
        <property type="gene ID" value="Gr19_v10_g16301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16301.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15212" checksum="BA38E951E14A5AEC" modified="2023-02-22" version="1">MRPSSSVQSSLRSAASVSAHSAALRNFAHIPKSISGHFDSDQQHHTTATTTTAKTLPFVPLQLHIVKDRKHERRRVIEQREGAKRQCPGRDNRRIAADKLGRAESIELNGLKRFSRKLEASARLEEADIARLKQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF01</accession>
    <name>A0A914HF01_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF01"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16008.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16008.t1"/>
        <property type="gene ID" value="Gr19_v10_g16008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="586"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16008.t1"/>
        </source>
    </evidence>
    <sequence length="791" mass="90575" checksum="A21762DC81291D4A" modified="2023-02-22" version="1">MMTSSPNTTDGDLTADKVYLWPSFAQPIAELADELARQRTDSPSPTESGFDLVSTDGGQNDEDGTGFGHAHVMATLQHDQLSEHQQLLTTPTAKKKCLAVLQVQRVDKSTTYCPSLRYEFFTTEAEPFSGTEHGNPTVGHMTRAILSKHLSMSMEQMASRFDLQVQIRERAFMPDTMFVDIDRQQCWAEPVEHRGEYKVLLHPKLADNNAGRIGGARKIVPEKVGGGRRCDDEDVLMSRQLAEFRDNIGSIEPSVTWLQQGKVKCVEHFSLLRAKIEELERKQKADQKEHRSKIDEMAKAKVAAELENQQLVENHKALNRKMEQYQNKQQQSQEENEKLLNAHKNLMEEMNLKQQQHQKESNDKIGWLNEDQQKLSVSIDHFLLMQSDQKALLERLNGLEQKQAAYAEQQKTDQKALRATIDQQFNEREEKLNNFLGHKQQQQTIGVLTERQKGIDPFRIMGFISLFILFIFSLNFVQAKVITELEEQKLSNANKFAELEQQNALQEKVVKMEKYQKDQQLNSAKMEKYQKEQQLNIANMEKYQKEQQLNIANMEKYQKEQQQKMEKYQKEQQQKMEKHQKEQQPTIDDLQKTVAAMRKIGLTVQNRWDSAACHQGLTLSETDRLIVQITGKNNWAWHSVFAERPIPKNELGIFYYEVTILEKANDVHIGLASNQMPLDVWVGYYKGTYGYESNGILWGHAVKGCHHSGKGRPFIKGKPAFEEADVIGCGVNLTTRQIIYTKNGQRLGTAGLFVDSSADLFPCVSLRDPGTKIEANFGPNFKFNITADGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFG1</accession>
    <name>A0A914HFG1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HFG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16487.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16487.t1"/>
        <property type="gene ID" value="Gr19_v10_g16487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16487.t1"/>
        </source>
    </evidence>
    <sequence length="446" mass="49102" checksum="F57E3B7EE82A33DF" modified="2023-02-22" version="1">MENVHDQLNTYQPKLASYLQALTDDDRATFITHLQKFDFSYLNSAFNRALEPKLPCAEDIQPIPAQQKVDRAQLSEGETERLTKIGLKAVAEGRVAAVVLAGGQASRLGSAHPKGVLRLGTGLGQNSSADSLLFIQAAQIARLQRMARERFPTEANESGGHITWLVMTSGTTDRETRDHLAAVFNKTGLSPAQLLVFTQNEIPAFDFNGHAFLKDQTQLVTAPDGNGGFYDAICPLLPELEKRGVQHLHIYCVDNILCRVADPLMIGCAIDRGADCTLKVIEKRDPAELVGHVCLVQGLVRVLEYSEITRELADRRCPNDPSKLFLNAGSIANHVVTLAFLREACAKADAVLPYHVARKRIPFWDPNLKTAVQPSEPNGIKLERFIFDAFTLSKTGLLWQVPAVEEFSPLKNPESAGVDCLSTCVHALKEPHAQWIREACISKLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFZ1</accession>
    <name>A0A914HFZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16601.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16601.t2"/>
        <property type="gene ID" value="Gr19_v10_g16601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="860"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="884"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16601.t2"/>
        </source>
    </evidence>
    <sequence length="1156" mass="129895" checksum="F426754FE9D1494C" modified="2023-02-22" version="1">MSVLHLQATQKTVVDIIYISLTIDNLIPWNIPGGQGRRLNVTEGSAQKHSRTKFTGAKGKKTNIFFRERLSGLEFEFTGSGCANPVLIPREFRSRRTLTPGPRKRNFKMDCDEETIDHEGTGKAELKQNDQEKKSKDEENDQKEKDKEEVDQEEKGMEEEGMKDEDDQEKKSKDEEDDQKEKDKEEVDQEEKGMEEEENVLEEKGMKEEDDQEKKSKDEEDDQKEKDKEEVDQEEKGMEEEENFLEEKGMKEEDDQEKKSKDEEDDQKEKDKEEVDQEEKGMEEEENFLRRKDMKEEDDQEKRSKDEEDDQKEEDREEVDQEEKGMEEEENFLGEKDMKGELDRDDKEKVDQEEKGLEGKKGDQKEKSKDEKENAQEQDGNKSKANEVPDEPPKTKKAALERLRNMHFAAKDPFKDKPLRDTAKYSLLSRTVRDRTPPPTLQRKNAEDERRRDRTRDESATKALSSASGRRRRSRSRPSRYRTDETNASASLIESRHMRGTMFFLQAEQKAAASSLSAQRSRIAQAGAKPLRERIDALLARPDHEVLTMNATEIRALILSGVELFRDQEHFLSGRKAQLIELDTMISQEKEAIEKISKELPNQFRPPPVDEILVQQQQRAAPLQQQQDQHIHQQFNGPLAAHNKQHHFVPPPFLSHQQKQLDFTVPPPSLNMQQPNEFSTPTLPPFANQFLRPPPSLPKPLPQSSAKMTQFGHSPSLLFTKPPPTSISSDDFSKCISTVPIHNPIVSSNANFAKADSQGGPTPNQQQLSAAKHAAPISLASIPHMSRPPSFGTGHHLPPTANNRPEQQQQHQSLLSQSKTPTSIPQLMVSNALKGIHSVSSTSATQSHSTPSFMTHNVQQQHVVGQQQQQQQNFQQPPPLSYTHSHQQQKQPPQASQSMLSMKSGNVVVVVPQQSQQHHYQQRTLTPLKHTSASSTSIASSSPNQQGASTPSQQAPRPLMSLSIGPPQPQQTKQHSRQSSSSIGHGSGTLGGRQQQQLQFANDGSADGSAARGGKSIRGRLKMVRGAGTRKQHTGKSSDRRPVGGMGLATKEQHHAPRRRRYSSPSPSPWPAAANASRPLESSSSGSVKRLKIEEDFEESSEAQEAEQFSSSSVTRPLSSFTTEPPVTVQAADTTTGGTTDNALVVDEYAALPVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG32</accession>
    <name>A0A914HG32_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG32"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17049.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17049.t1"/>
        <property type="gene ID" value="Gr19_v10_g17049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17049.t1"/>
        </source>
    </evidence>
    <sequence length="646" mass="72287" checksum="18FD10CACF74735E" modified="2023-02-22" version="1">MVIGTRLSPSPAAVPKPARTVVAFGRGQTVANAVAAKKAAAAERAQTTTAAKTAPGLSGTSNSMRRSGSLGHLVTSASAIHAQANLNGQRTLCKCSEPDSVAFLEGVYVQNLQTQIEVLELENAYLRGATERGALFAKHHQTPTSSAVTNRGTSTTATTKIMHRRNSTASTTALRMTESEEEKEEEEEKEEEKEEVEKQHRRQRHSIGTPKRRVAFINDHRPPPHYRRRQGAESSSSSAEDAATASVDEMYGIDGTGGRDNGTRRQQRKLERNTYDGATPEAEGVSHAAAAAVEDERRRRRAAERLQQEAELRAVDAEQQLREAEERAYGEKRALLADSAELQRRLDELTPKLAEQEAKMLALDEQRDDANVRLKATVKQLNALQANLADRTRESRQLESDRERNVQRLQRQLEELGRELDGARTREEAINIELDRAKNRLVEEESRNQREMLAQSRTEQEEKSKLEAQLMEAHQNGELASAELELARERLAKEQEAVRALSTKLKERQLEDEQRGSARLRVQRELEALQSLSNSLANENKGLREERGALEERLNELKQRVHQKDSRGHRLAELVSEFFDKHRQSAQRAKIQIGRQTEDCEQFEQIAEKIRQIAGTGTSPPRASATTTTSVSSSRTTSSTRRSKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGZ9</accession>
    <name>A0A914HGZ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGZ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16865.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16865.t2"/>
        <property type="gene ID" value="Gr19_v10_g16865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16865.t2"/>
        </source>
    </evidence>
    <sequence length="96" mass="10901" checksum="B1FE81EA55C33FE2" modified="2023-02-22" version="1">MLCRLQGIVVKMEKYQKGQQLRIVGLQKTVATLRGPQNRWDLTKSHRGLTISGLIVVAENANWGPCSVFAALPIPTKKDFGIFYFEVTIQEQKHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH99</accession>
    <name>A0A914HH99_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH99"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17496.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17496.t1"/>
        <property type="gene ID" value="Gr19_v10_g17496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040436">
        <property type="entry name" value="Disconnected-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021:SF0">
        <property type="entry name" value="DISCO-RELATED, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021">
        <property type="entry name" value="DISCONNECTED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17496.t1"/>
        </source>
    </evidence>
    <sequence length="901" mass="99801" checksum="B68A4509A908A10F" modified="2023-02-22" version="1">MHKKCEEIKAQARHALKALQDYGEQKSRKMLFPETDAAVFLAVKYKKVPLARGTSLRKFIALPYSDRNPLNTSICLILPDRNRSAAAAKDPDVDEQAREWAELLRDKYALTGKHIAKIFTLTQLKREYGRQADKAKLANTYDIFMVDKKLMKIALFFLGSSFKKATKMPLPIDSSVDISKKLNESFSLVQLHLAPLKDAVTLRIGNLGQPLNELESNFNAIIEAVFTHFPGGSLNIRSCHLQTAATKVSLPIFVDFGPANEVRLEMPKKQQLAVEVDGCSTLPDGLMVKVRADGKVIVVEEKTGDEVLYPTGQDEWEHNDDIRPLTGEALHKVLRKKANRLANGRRWRDVKEEETAPHEGNDGVDDDDDGETLSNEKKMEIMPGHEKGTKQKQVERSSRKRRRNSESVGGGSDDEKFQSGSRPSLLFVSRPWIINSSLPPFPSLLRPRLRPLFCCVPPTIRCCRLRPLPPLPLPLPLHCSSPLPPPPHLHNSSTPFFSLHSSPFCWTVSTPFQYVLRFSSTGCSTLFRLPTATPSFRASVGHQRTLRAVTSPIRPPTTTGFMCLYTPNFGCFPLSAPPCPIWPRSPIPFGSRCSIRCSLLRWEPTKEGEEGAAGTERDGGGGGTDKGRGLSDTEMADDDLSSVGNSNGRLDGRNSKPPVAEEAIVHRLQREEGIGDEWTSERAATTTSSSSTPPCISSSCSRGTGRMRTSRSGAGKRRVQCQICLKTYCDKGALKIHNSAVHLKETHFCTVKGCDRAFSSRRSRNRHSLNSNMHSALFLVDSAPETDAAGKGGEPVVAHPMQAAGENMAKVNGEQQRNSTVVLFPSVPTHLHQQQQQQQQKPNRKKWPTDGQSSPAAINLGLSFANSHAIPRGWGSQNDYANANHSTLFPRERRHIRRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHD5</accession>
    <name>A0A914HHD5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">microtubule-severing ATPase</fullName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914HHD5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1752.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1752.t1"/>
        <property type="gene ID" value="Gr19_v10_g1752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001054">
        <property type="entry name" value="ATPase, AAA family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037364245" description="microtubule-severing ATPase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="346"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1752.t1"/>
        </source>
    </evidence>
    <sequence length="593" mass="65763" checksum="3660B565ECD75C5C" modified="2023-02-22" version="1">MDLLVLIISVIFPFLSAMPPSPNRTTLEMLLKNKETVDTSNDRTDDIQAIVRQAKSADPNVRFEAVNRARILLSASKNAKELPISEFISAGFLPILVNCLESDDATNLVWFASWTLANIACGSTDQRNAIVEAGVVPRLVNLLQSSNVNACVHAGRALDNIVSGGPDLAHAVVKAGAVPKCLKLLESSIENVRTKAVQVLTSIIEKIPNFDDYSIDEEHIQIMRDEQLTQKILRGIMQILKKEQHRDVFIKKMEACGGLDKIEQLERQESKEILKMCIKRHQPISRENLLKNVEAKFGEEILSHIVQTSGIQLSDIEENVTAKAALETSVVLPALNPGLFTGLRAPPKGILLFGPPGNGKTMLAKAVANECQATFFSISASTIASKWYGESENLVKTLFQMARNAQPSIIFIDEIDSLLCQRSSKDGDGARRVKTEFLVQMDGFSSSSMANERVLVLGATNRPQDLDEAVLRRFSRRIFVDLPNSKARAKMIQNTFERTKTKLELSDDELAEIANKTENYSYSDLWDVCVAAAYCPVQSARENDWLLRKTTGDKLRPVTATDLECAMRTVKASSNAENRQELIEFAKKYAKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHS4</accession>
    <name>A0A914HHS4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHS4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17062.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17062.t1"/>
        <property type="gene ID" value="Gr19_v10_g17062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17062.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="8787" checksum="85159A98718086A8" modified="2023-02-22" version="1">MAKANGHNPFCVYPALIGPHPSPGKRPGATNPTEFSGSSFDEEHGAGEPPAGGFQGTFEAGVGPFKPGGRKRRMALGPIYAGDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHV1</accession>
    <name>A0A914HHV1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHV1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17302.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17302.t1"/>
        <property type="gene ID" value="Gr19_v10_g17302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17302.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="12730" checksum="E510E90BCE39B4EF" modified="2023-02-22" version="1">MEMANQLNRHRRHHKRIRIHIRVRDQQTGEYGYGSGAYSARGYGGYGSGAYSARGYGGYGSGAYSARGYGGYGSGAYSAGGYGSGAYSAGGYGSGAYSAGGYGSGAYSAGGYGGYGSGAYSAVGYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHZ5</accession>
    <name>A0A914HHZ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHZ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17330.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17330.t1"/>
        <property type="gene ID" value="Gr19_v10_g17330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF24">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="334"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17330.t1"/>
        </source>
    </evidence>
    <sequence length="673" mass="75190" checksum="BF1BF1B88C424FB4" modified="2023-02-22" version="1">MRVQSIKSCLIASVTMCLISTLLIGLASLTPGWRSINGKIRLHDRTSRSFSISTGLFGFLCSTVTDQTAKVEDFCLDWANSVSFFERFVSVLCIISALVGVIALFWSLIILLDLFPDWENKPRWALPALAFITFILAIVAATVYFFWGCSENDNFVVHWTSSPSSSSPSGKCSLNYSFFIFLAGCFAALFGFVAALMVMLLKKSLASANPLSMLFLASALESAPSNSLWNRQIPSPHFLWHWQQISKGFFTANRQFASEAMRCFGRFCKRSKTDLFTFWHCSPDCVEWTLPGGAGPGGSCEEVDHNPPTLDELSRVIYSILMPFVCLLGSVGALISLSSFDFVLLVCAVIIYPSMNLCLQDGNRGLVCHFFWRTSLATYPVSLMAQTASVWTVVAITIDRYLAVKYPLHMRAWCTAHRAQTVVLSITAVAALFKMPSFFEVALNDCGRLTKTELRQDHLYFIIYYTYGYLLLMLAAPFLFIIVLNAQILSIIRKANVQRCEMRVIRKRTNHSSGIGIVVDGGGRDSFGNGTVQPNQPPQKGDQLKGTSQLTTNSTLNAFFYQQESASSVTTALDSRCTKMAVVTISAFVSFNWLAGINHVIEAFDLVRDDGRNMRIPIGNFLVCLNSATNIFIYSLFGRRFRHQFCRIFCHCSTRKYDQMNRSICPQNKTDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIE1</accession>
    <name>A0A914HIE1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIE1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17649.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17649.t1"/>
        <property type="gene ID" value="Gr19_v10_g17649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17649.t1"/>
        </source>
    </evidence>
    <sequence length="548" mass="60535" checksum="37B8DA011BB9A1D3" modified="2023-02-22" version="1">MFNIVNPKALFERRYTTKNNRKWHRQERQKRLTGIQALKSHIIAAKHVANTLKTSLGPRGLDKMLVSSDGEVTITNDGATIMKNMDVEHHVAKLMVELSQSQDDEIGDGTTGVVVLAGALLEHAESLLDKGIHPTKIADGFELACKKALEKLEAIAQQFPIEDREALVKSAMTALGSKVVNKCLRQLGEIAVDAVLSVADLGQHDVNFELIKVIGKVGGRMEETALIKGVVIDKTLSHPQMPRRIENAKIAILTCPFEPPKPKTKHKLDITSTDEFKQLQRYEKETFEKMINEVKSCGATLALCQWGFDDEANHLLLHHQLPAVRWVGGPEIELVAIATNGRIVPRFAELTKEKLGISGLVHELKFGTDNEQMLCIEQCPNSRAVTVLIRGGNKMVIEETKRSLHDAFCVVRNLIRDNKVVYGGGAAELACAIAVAEEADRVAGVEQYAFRAFADALESIPAALAENSGLPPIDTLTDLKAKQIEGQKPWLGVDCLQMGTNDMMEQGVIETLLSKKEQISLATQVVRMVLKIDDVRVPDDEERNYPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIP0</accession>
    <name>A0A914HIP0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIP0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17732.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17732.t1"/>
        <property type="gene ID" value="Gr19_v10_g17732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17732.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24742" checksum="0F2E38EE5743C2D3" modified="2023-02-22" version="1">MQRFFGSSKPKAPAPNLGDAITTIDARGESVEKKVAKLDGELVKLRDQMKKMREGPAKNMVKQKALRIMKQKKIYENQRDQLYAQSFNMEQSNFAIQGMKDNQVTVAAMKDGLKAMKQEYKKLDIDKIDTLQDEMEDMLEMNSEIQDALSRQYDTPDIDEAELEAELEALGDDLQFDADTSYLDEAISAPNVPTRDPASASTVTDQGVAVDEFGLPKIPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIX8</accession>
    <name>A0A914HIX8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIX8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1878.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1878.t1"/>
        <property type="gene ID" value="Gr19_v10_g1878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1878.t1"/>
        </source>
    </evidence>
    <sequence length="388" mass="41495" checksum="DE1F1C4A04123150" modified="2023-02-22" version="1">MALLPATTPRPIGKFPKGLIKGSLPILASSALYFGVDTLANALEDDDPPSDHSVLITVLICLGGLALLILLKLLTILINYRSRPEATPPDPSLELGDLRAAVSDSILNHLKISAVPSDDPPPSPSQPLTPSLVRSTGTEMEIDNPADPPHHTEPEWAHTLESSLPPDRNPLASSPPGTQPASASIYSSFSSCSSPPTPNSASSTPSAAHPDLEPTPNFVVTLNELPGPPVSHTPPHPRVRGPSPAPTCPTTPAQPIEVIMGVTGRAAPRNSAHPPFNPRPAQRPGRLRHVRRSAPTSRGRFGASGHAPRAYVHGRWPRWRNGPAPPAPERPIPLNSIRFDTPPPNLPVVLGQCKHPFHMHCIVKWTNTQSGQKPACPLCRQEWKFATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJR2</accession>
    <name>A0A914HJR2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJR2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2120.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2120.t1"/>
        <property type="gene ID" value="Gr19_v10_g2120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2120.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41728" checksum="E53F755B10EE239D" modified="2023-02-22" version="1">MYRRKRFRRKCVGAKDSGANVSAQKIPAQMFGAKDSGANVSAQKIPAQMCRRKRFRRKCSAQKIPAQKIPAQMCRRKRFRRKRFRRKCVGAKDSGAKDSGANVRRKRFRRKRFRRKCVGAKDSGAKDSGANVSAQKIPAQMFGAKDSGANVSAQKIPAQMCRRKRFRRKCVGAKDSGANVSAQKIPAQMCRRKRFRRKCVGAKDSGANVSAQKIPAQMCRRKRFRRKCVGAKDSGANVSAQKIPAQMFGAKDSGANVSAQKIPAQMCRRKRFRRKCVGAKDSGANVSAQKIPAQMCRRKRFRRKRFRRKCVGAKDSGANVRRKRFRRKCVGAKDSGANVSAQKIPAQMFGAKDSGANVSAQKIPAQKMHHLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLL6</accession>
    <name>A0A914HLL6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914HLL6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17763.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17763.t1"/>
        <property type="gene ID" value="Gr19_v10_g17763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01336">
        <property type="entry name" value="MDH_cytoplasmic_cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000002">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011274">
        <property type="entry name" value="Malate_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01758">
        <property type="entry name" value="MDH_euk_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="158"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17763.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38138" checksum="F733AF23B290B258" modified="2023-02-22" version="1">MVPPPIRVLVTGAAGQIGYSLVLQIAKGDVFGKDQPIVLVLLDIPPMAEVLSGVHFELMDCALANLAGVEAVTTEEQAFKDIDYAFLVGAMPRREGMERKDLLAANVKIFKSQGEALARFSKPSVKVLVVGNPANTNAYICAKYAASKIPAKNFSAMTRLDHNRAMAQVAHKCGGLSVDMVKNVIIWGNHSSTQFPDIRHAKVTKGGSEVAAYQAVNDTAWIQDQFIKIVQKRGAVIIEKRKLSSAMSAAKAACDHIHDWHFGTPSGQWVSMAVPSDGSYGIPEGLIFSFPVNVDAQSREWKIVQGLDLDDFAKQKIDITTKELLAERDEALEACNVVPDKLNAVKVFSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLX9</accession>
    <name>A0A914HLX9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLX9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2349.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2349.t1"/>
        <property type="gene ID" value="Gr19_v10_g2349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2349.t1"/>
        </source>
    </evidence>
    <sequence length="1179" mass="131913" checksum="C294C42047C3C273" modified="2023-02-22" version="1">MVNRSPYNLRPNREAIRRGDESFQSLPAALHGENPDFLRNVNLVRGDQHPPQFSGLQNQQPNPIGFPVAASSPVHDLGPNLVYIQPQWNHSPQVSFENRQSRLERNDGVQNPMDHQGPIFLANPIVEQPGQNQIANQNETVVRQTVAGQNRALPRGVPVFQQNLNQQAQQQQGVGVNGAPRAQNIVFGNIGNAGNFVPVQFHPPVQPQFQTQAFAVPHQIQTGLVPQPWPTQRISQEQQSEMLLELHRVTLSNQYASVIKDLPTLFGTEGRDSVHDFFITMESCTREWREEKKMDALRTKLKGKALKALNMAFNKFGQAAPYSTIKAEILSILRETDHKEATAFAELTQFGLRNADEDITKFADRIQKLVRCAYTGINDVQLDEIAKKFFVLNINDRDLARFLECQNKTSQTYDEMVMLANKLNLLDPEKVQAQIEGKNRGKVQQRENTGRTDARAQNQPNFLNRSRPWQQNRYNPNFRSASYAPVREPYQNSSPNCQPQHSSRSNQPQSNFLPQHQNYQPPGFNPGQNRGYQNRNYPIQGTGANTIPLNSGQKNSNIRPQANSIVIGNPVGEQSETPTVKVSLVGQCELSECEKFFHLLATHASEFPSTNPAIPKTAECISVEVNVVENKAKALIDSGAETNVVNPAFLHKISSAEGTNLMEWGFNPNTGSTKIPFEVTSFTGSRISIVGAINVPITRGKITCEVPCLITQEPFSYDFVLANPEDHSKYIIENIMENDNISLDCSDCEEEFEKVKQMSKEQEEHELVQLGILAGDKLSVHRSKSAPTKIDFSKLPIHQCGIVERMLVESDDEHLYGLEFNSVCSGEGEHSKCAPIQLGQIFCSLPDDDPIRRIRVETLGELISLQLAKDVLIGHVREWAGCENPSAADKLLKYKMLSQALEDVRAKKLYGKVRTVRSTFAFFGDGATEMLGEKLASEMVLGKNSTELANSISKLSFGKELKEILVAFGTSDLNEDIPLDQTKAALQKILFHLGKFSVKVLIIPPPFNLSKKPEYEKLLKMFWETVPKDGKIQLALIKEFRSLAEVTRYGAEEEKRNVQADGKFKPCGVRETIKFLREVFGMSTPDKVFTVPKPVAKNVPSHSVEAQNYQFRVSGPRPLTSIQPAGPRPAFIRSGTDSARESPLSSTRTRLLRAGGGRARNYRTDKSPLRTAAFWRRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPF9</accession>
    <name>A0A914HPF9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPF9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3435.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3435.t1"/>
        <property type="gene ID" value="Gr19_v10_g3435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038047641" evidence="2">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3435.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20086" checksum="FFD4D9EE9A6F4D42" modified="2023-02-22" version="1">MFFENFIFVVIKLLFLVKIGHVSSCEKTVFYNGCCNNFPLFACPKPFEPPNCNFIDHNCVACNYIYNKTNACSERSIGNSSPSMLEAEAKAWEHFDMIDVDKNGSISLNEAIDHLETKLKNGTSGKNLAKKVSWFAEMDSNGNNQIEPGDVHSKCPVDVVFLPRSRGHLGQSKNDDLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ98</accession>
    <name>A0A914HQ98_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ98"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2895.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2895.t1"/>
        <property type="gene ID" value="Gr19_v10_g2895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF334">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2895.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="30009" checksum="746D094A16C298A0" modified="2023-02-22" version="1">MLLDQVIDFISAQADGLWGDLLRMGAGTPSNRKRRAAIVATEEDHNNLQANRHPRSGYSVASAVPAPPCKCEMDNACPQGPSGPPGDNGPSGLSGLPGKDGVPGVSAPDWHRGPLKGCFNCPAGPQGSPGEAGRPGVRGMRGPKGSPGMPGRDGVPGLPGIQGDEGGQGADGLPGKGGEHGQDAEKPIGRRGSKGPPGEHGIEGPIGSSGNPGPVGKQGHPGQMGPHGFEGPPGADGDEGGLGTAGKLGRDAAYCPCPGRDGHKGRGGGAGGHEHGGVQRGEAGGGSEFGEAHKSAGGYRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQJ5</accession>
    <name>A0A914HQJ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQJ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3330.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3330.t1"/>
        <property type="gene ID" value="Gr19_v10_g3330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3330.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14656" checksum="E4B640B3ABA77580" modified="2023-02-22" version="1">MKAELKRAGFKNSYPNQIDETVAKELGLSFMTIYRWKRKLGQTKSNKHSHSEQMELMKRYYDIKDNNRKIRDEDIAKMLKIGSGTLVRWKKQFKRQQLHPNSVDSVEENAAGANIQEIVKSNLGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQN3</accession>
    <name>A0A914HQN3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQN3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3004.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3004.t2"/>
        <property type="gene ID" value="Gr19_v10_g3004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="104"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="332"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3004.t2"/>
        </source>
    </evidence>
    <sequence length="539" mass="61292" checksum="0AC06DCDC9504EA9" modified="2023-02-22" version="1">MALITDVDEDLTEFNITHNEHQDELFVTWTAINNSFYGSRICVQIEQLLPSSIVADNTAEYHGSGGRMCGQYRIHTSQGRSYKVGLQLFIKKSRDDPEVQTHALIKFFVPESTVQRLFLICPQNRWNSSDCQQGLYILRDGLTVSRHKLGSPRAAIFTSVRAEMLIPQHYCGLFYFEVKLERMFERFRFGLMPKSVSLNTSYASYSYKSDGTFWGHNVAGCDFANAWPFVTNKESEFGSDDIVGCGLNMATRQMIYTLNGRRLNTTDLLVHQSDLCPFISLNDAGDAAKANFGPEFKYDLEEEYLTIPAVQTIEHRTVINQQAARANVVALGEEHWQPPTELEQLYLICPKNRWNSFDCHSDLFVIRPDCRTVFRHDVSSPDACAVRAEIVIPRHHCGLFYFEVKVEEMRIGCRFGLMPKKMGLNSASHTSFSYRSDGTFWGHGVPGSVRVNNWPYVTNKDAKFGVGDIVGCGLNMASRQMIYTLNGRRLSTSGLLVPQDDKLELYPFISLKDAEDRVMGNFGPHFRFNLAEEYLIPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR14</accession>
    <name>A0A914HR14_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR14"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3452.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3452.t1"/>
        <property type="gene ID" value="Gr19_v10_g3452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3452.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9947" checksum="0F3360A2CA320A87" modified="2023-02-22" version="1">MSNYRNSVPFVPKNELIISERTKQLYIGQLAAFLTGASISRRSYLTRERMVHQWISNWGRGWEIAFVDILEHLRSSWEMNDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT58</accession>
    <name>A0A914HT58_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="Gr19_v10_g4418"/>
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        <property type="component" value="Unplaced"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="81"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4418.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="33549" checksum="7EE060F925B944FA" modified="2023-02-22" version="1">MSASSSQPKDQSTSSHKSADQKQLVVVAPGTSVKAANRLVLLCETEVQLEKLALDTQRDQNKKSDASCANDGEEVKLFFKLAERGGAAKMRAMLKGPNADVLLRAKVNGVTALSVAVQQGNTEVAELLRAKGVMDVKSPAVTFGWDGAVVAEQPIPPKKDSGIFYYEMTILKLKQNAVVRIGLATIRPWDIPFLFLFKQGRPDKFWGYASNGIIVHGNIPLLNILKEEEEEVSEPFGVGDVVGCGVDLATRQLIYMKNGARLAIPDLFVSSTTGDLFPFVTFHVLGDGPSDGKIEANVGPNFKYKLAVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTG2</accession>
    <name>A0A914HTG2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTG2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g406.t1">
        <property type="protein sequence ID" value="Gr19_v10_g406.t1"/>
        <property type="gene ID" value="Gr19_v10_g406"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g5048.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5048.t1"/>
        <property type="gene ID" value="Gr19_v10_g5048"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g5061.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5061.t1"/>
        <property type="gene ID" value="Gr19_v10_g5061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g406.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5048.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5061.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11098" checksum="462CF8B06822F979" modified="2023-02-22" version="1">MDLVHSSPLPIFNSNTATTSAHSKLVYAVRRNNSPTMSDLSAYMSSPSAAAPATGGAQSAYMSSPGGEAPAAGGEAPAASGGGAQSAYMSSPTYNQPEPTPAKAPEQSAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTJ7</accession>
    <name>A0A914HTJ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ligand-gated ion channel 50</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTJ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g384.t1">
        <property type="protein sequence ID" value="Gr19_v10_g384.t1"/>
        <property type="gene ID" value="Gr19_v10_g384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000061">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="165"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="375"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g384.t1"/>
        </source>
    </evidence>
    <sequence length="519" mass="59621" checksum="FA63764331C34A1D" modified="2023-02-22" version="1">MVDSGQQHPGTSESPPCPFPTSSIPNFINDDSPPQRESSLCAAPSPSPHRPDSVPVVHFAHLIGTLFMFIILLFPVLITAQFIPLRAALTSSKAFPPIIEEPISRRPMAAKRLKKRLLTTAKRSLTLSTTAINNTPSSNNSIIVPSYATFPDYCANDTDVIDHILYDTTVHYNLYKLPANPVSVRIELWIQEVTSVSELTQDFEIDLYVNEFWEDPGLSYDYLRPCKGNLSFDHTFLRTIWAPNTCFINSKSAKIHESPFRNVFLMIFPNGSIWSCWRIKATGPCKMDLHKFPMDSINCWLTFESYNYNNNEVRMRWNQPTPVLKFKEINLPDFYMVNHSISIREANYSAGLWDELTVHFHFQRRYGWYLLQGFYPSFLFMFTSWIPFYLGPKAIPARTMIGVNALLAMIFQFGAIIRNLPRVNYVKAIDWWILCGMTFIFASLVELAAVGFKMRNEGRATFRVKDLPKRGGRGGKRKTDALVSCERLDHYSRIAFPAIYTLFNVIYWTYYMFIAKSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTQ0</accession>
    <name>A0A914HTQ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTQ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4125.t3">
        <property type="protein sequence ID" value="Gr19_v10_g4125.t3"/>
        <property type="gene ID" value="Gr19_v10_g4125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4125.t3"/>
        </source>
    </evidence>
    <sequence length="74" mass="8708" checksum="8C887B9B40FBB44B" modified="2023-02-22" version="1">MEGNHSCRLFMCIFYSPQLQKQFKTIAPPPPLLLQSIQLLLSSRQQPAGECQWPSLLQDWTDAVHYLFFAKWHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTW0</accession>
    <name>A0A914HTW0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914HTW0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4163.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4163.t2"/>
        <property type="gene ID" value="Gr19_v10_g4163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000024">
        <property type="entry name" value="Histone deacetylase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4163.t2"/>
        </source>
    </evidence>
    <sequence length="415" mass="47017" checksum="85B070CDC53F2027" modified="2023-02-22" version="1">MTNKRRIFYYHHPDLGNFHYGPQHPMKPARLAATHSLVLNYELHKHLTCVHPPRATQHDLARFHAPEYVHFLKRISPLNADQYEGQFHRFNIGEDWFVCPVFDGIFDFCSLYTGGTLEGAIRLNHGQAEIAINWSGGLHHAKKSEASGFCYVNDIVIGIIELLKYHPRVLYIDIDIHHGDGVQEAFNLTDRVMTVSFHRYGGYFFPGTGDMFDVGMGHGRYFSVNVPLREGMDDESYHSVFKPVIQSVVDNYSPSVIVLQCGADSLGSDRLGCFNLSFDGHGECVRFVKSLGLPLLILGGGGYTLRNVARCWANETAILVDRDAEISNEIPDNSEYLEYFAPEFTLRPELPKRIENANSKEYLAAIKTEVLENIKLVRNSPSVQLQPVPGDALDLQDTDSMRRERREDGLDFRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU02</accession>
    <name>A0A914HU02_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <organism evidence="11 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HU02"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17845.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17845.t1"/>
        <property type="gene ID" value="Gr19_v10_g17845"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g4455.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4455.t1"/>
        <property type="gene ID" value="Gr19_v10_g4455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="10">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17845.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4455.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18197" checksum="7F1FAC5553F30BAC" modified="2023-02-22" version="1">MAESTDHDHDFTSGESASAPTYPKQCSALRKNEFVMIKGRPCKVVEMSTSKTGKHGHAKVHMVALDIFTNKKLEDICPSTHNMDVPVVKRKEYQLLSVNEDGFVSMMDLESCETKDDLRLPEGEIGDQIKQAYEKDESGILVSVVTACGYGCCCEDGAADGDDGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUQ5</accession>
    <name>A0A914HUQ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g466.t1">
        <property type="protein sequence ID" value="Gr19_v10_g466.t1"/>
        <property type="gene ID" value="Gr19_v10_g466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037402835" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g466.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10402" checksum="C4313C8D32B6489E" modified="2023-02-22" version="1">MFMKRSLPLLLLILLLLLVSLVVGYSPSGSAKGHHMKLRKRINYSDGGVLGLNAARKTRMPTRKMVEKPRMRFKVTGGSKLAPKHNTITAHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVC8</accession>
    <name>A0A914HVC8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVC8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4515.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4515.t1"/>
        <property type="gene ID" value="Gr19_v10_g4515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036850722" evidence="2">
        <location>
            <begin position="22"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4515.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43849" checksum="5A139BE9E744E41F" modified="2023-02-22" version="1">MNKWAATSLVILIAILCAAHGKATDPPTAVNQQTSKPYAPEDNPDIKRKYTVGRVYWDDVNKVCRRKVNETAPESKMDEILTNQTIVVDPETVKEVFPKAEICNDTLFNDWSYCAKVMFYGEEGVIEARKYFGKDKAPGKEFANMTEFDNYGFMQDMVLLLIDGCIECKNATEEMEVTLSITQKLKAGKILSLCGEEKMHEFGKTTVTLEKGTANFVFGVVLRERLCPHNKVPDKVPNNINDLVIQNLTYKYENVSLMVTHSCRGEETNVSMMLPTIYVFNLTGMDRVLQLRDLELNLTTLNVGATLNQSAVRMKDPTSGIYYIVSVVPGPEPVTTMATGKTSKPTKMPSTKMPPTKMPPTEMPKPTVTDKNMTTMAPTDKTPKRTKMPKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWK8</accession>
    <name>A0A914HWK8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
            <location evidence="1 13">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5148.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5148.t1"/>
        <property type="gene ID" value="Gr19_v10_g5148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="15">
        <location>
            <begin position="49"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="982"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1047"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1195"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1284"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1332"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1195"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1294"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1337"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1367"/>
            <end position="1395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5148.t1"/>
        </source>
    </evidence>
    <sequence length="1562" mass="177017" checksum="17F99E0BE52951BF" modified="2023-02-22" version="1">MTNSRDTTRKETVGFCCLTWHVFETAFEGVGERDGRRGSACRRRRVQKVCAMQRKANSKPMSSIMAKMGEFYKDYLDFIIFPEETILSEAVENWPLCDCLISFHSTDFPLKKAIEYEKLRRPYVLNDLHRQFDLLDRRKVFRTLARAGIDHPRHCVLIRNEKGELVGDELREFADHIEVNGMTFNKPFVEKPVNAEDHNIYIYYPSSVGGGSQRLFRKVNDRSSWYSPVSTVRKEGSYLYEEFIPADGTDVKVYAVGPYYAHAEARKAPGLDGKVERDADGKEVRYPVILSAKEKTIARRVVLAFGQSVCGFDLLRANGCSYVCDVNGFSFVKTSTKYYEDTAKILGNTILRRLASSLSIPWHIPFQDDDPPLVSTPSGKIMELRCVLAVIRHGDRTPKQKMKVAVKDERFWKMFQKYDGLRKRELKLKKPTQLMEILEIVRQLLQESLEQRRSLLGKNTHFLWEKRDGSASVGAEHSLTNELEKCEEAIKTWEQMRAVLEMYGHFSGINRKVQLKYLKTRTEKGTAGSKGSFVLEAGKSVLQNPSGALGDDDSQFASVPTLFLILKWGGELTTAGVLQAEALGRLFRTLYPGIRRTDGKESPEDTQGLGFLRLHSTYRHDLKIYSSDEGRVQMTAAAFARGLLALEGELTPILMQMVKSANTDGLLNDDYNARQFQNDIKSFLHSALQEDRDFTPSDYQSLNPSGLRSINNALEFIKNARKMCHEIAGYVQRMCEIIRWHKLNLNNTERTLYLNETWDLAERRWTKELREFRKPSKNGAGDGFDFDISKIPDIYDNIKYDMEHNPDLCINNEGEFERFYLCVKNMADIVVPQEYGINEESKICIAQRSTSNEAGDESLTRLDPRASEGIATPMRHVRTRLYFTSESHIHTLMNLIRYGGLCSPDDKKWQRAMNFLSGVTEFNYMTQLVLMVYEDSRTEEEKSEGGRQQGTDIKDRFHIELLFSPGLYPCFQTEKERIYESRYSNRHKTSTSDGNKCTKGNRHNNSTAAGGGNENTLSGCGEDKVYSSASLATKLTEVLDIGKFSENSQIDDCPTRESASTQPKCSNRAGNESTSEESYTKEEGNGGTYRQNSRKSADDDDDLPEENAVNLVVLDEVSAASGAKTFCKGDLARHSPTSMEHPMRKRHATFERDSLKTLSKSREEGTKVKEKTMSEFEKKCEDGNGVGERLITFERRESDGRERQERPHGHQHYQKSIVKSMSDLFANRQKLEEIANDDEDDFKSDVNDGGCAPSGVIAQSANELKLDEGQATVGHGRGEWAKQLLEGTKVKEGQSPTKQQNVSGDIGIGEDVRPNCSSTNIARIPLSSVFEGISTDGQKEGADGSDRSTEEETNRRKKEQQKDTNSKEQTIGTRNSPDTTESTESTIHTQQSSATIKDEDTEEHNRLSFRRTRFPYRFKHHTVNLLTGAATENRLISTDVLMGKFSDKTKRKASSNSVVLSTAVIGVRSSSAPRLQTYNAGDELSVNEIRRFWPPLRSLETMHDNLSWKEVDEFLKRMMKNCTPLPSPPKTPATHFDESVPMLFADKRKSDSTICRLPPLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX27</accession>
    <name>A0A914HX27_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX27"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4579.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4579.t1"/>
        <property type="gene ID" value="Gr19_v10_g4579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037585852" evidence="2">
        <location>
            <begin position="29"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4579.t1"/>
        </source>
    </evidence>
    <sequence length="492" mass="57815" checksum="387557F232D96BE5" modified="2023-02-22" version="1">MSSSPIVLELVLLLTIAVLVAFTPSADALRCSIGGGADFEFDEDLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLEMILLLELILLLEMILLLEMILLLECLESWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX38</accession>
    <name>A0A914HX38_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX38"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4587.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4587.t1"/>
        <property type="gene ID" value="Gr19_v10_g4587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4587.t1"/>
        </source>
    </evidence>
    <sequence length="605" mass="63717" checksum="7F52F81D38A1EA9F" modified="2023-02-22" version="1">MPICVPPNLHTFRFYRRPERPKIRWGLLLCSVGKCHHHHSADDGLIKNFILHSFTPSPTIPKTSNPRPTKTDQQQPATRHSFIRSSSDQRDEQNNDGDENNKKKAYVCHSLYIVVSQSVMDKTNGNDSNFHQQQTGQFFHNNLSRYRFNHHPFLPSLAQQQMVLMMSSESEENSGGGGSGSATASVGSKTTDHQHRLQKQNSNTSSSNTTFVSSSSSNNTVYSSMFSSSRLLDDEDPVFSLDEEVLAKAQSGERTRHYTADFDPTVSDDDVDDLAKDAGKLHGGRAFSATHRFPPRTRHSGRSGIHAPAVVGIANLATAAPVGGHGHANHRTVVPASLPIAISRGAGAGVGGCGGFPSLERVVGSLSEEEESGGGCIAGGAGQTVPSPPQAVPPTTTAAGERLAKANKQPKTAIDHALVPYLLAGRAERKQRAGGSEREEGDLFGRIQAYSRSIQPADDPERLFGERPRRHQHNYNNNTKQQLENNSSVVEGENIPPPPSIAAAAAVGDFGVSRNNSDGRHGVCGGGVVVAAGNVTTTTAAGTSAAVMLDNNYGGGAGAGGMGAPATTTAVTTASAGGAAAAGGGARAVVGTPRIIVPTSLRAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXN8</accession>
    <name>A0A914HXN8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXN8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5618.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5618.t1"/>
        <property type="gene ID" value="Gr19_v10_g5618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5618.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27303" checksum="60EAC9B035272A09" modified="2023-02-22" version="1">MLINNESSSELLQPYCDTIEKVLLGSDYFVMHIQLLLLGAELILICILFRYYGKHRIAIHGNLRLLFANILALYFIHSLAWFVYFMRYRILLYTYSNACDLLSPVWMVPVFMGPYQVYSVAYPSFHFAVTFERIRATFLAHKYEKMGPQLIIKIICAIWLGSLAYLVVIVCFALADRNLWPPPRRRLFDLRLQRQCHIFGDDFHNDFGDCDGTVRLVHLFAEQTASQIDETWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXT3</accession>
    <name>A0A914HXT3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Non-specific protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXT3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5465.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5465.t1"/>
        <property type="gene ID" value="Gr19_v10_g5465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="115"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5465.t1"/>
        </source>
    </evidence>
    <sequence length="439" mass="50786" checksum="EE2E688949E70882" modified="2023-02-22" version="1">MRPIEALKFSLMNCAFFYRPPLSFRETAELLERDGDFLVQDSRGAKLLLSVRVYGVVSEFGITIVQHQSHRVLFEFAENCFASLEELVLTYSRGRSGKHFLKTPDGDEFVLIRPILRQSHVGRFGYGERMEVRDCLRKGKWLPSFVRTLRPEFAAHEKTETDLERLIELDHRNLVRICDYFKQLRNDPSGRVPVVIVRFELVTSGQSLFDKLFHLHSVLNAKQYISWAFQAGNGLCYLMDHGFLHRRLQARACILDSSGKVLRIGDFWSENDSGDMHLFQRDAYLPNTVLPSAVMYRDGWRYLPTETLIDSKFDSASQVWCYALLVWQIYTHCQFGNRIYYSSLSEFLSLSAAVDDPYFMPGHLSRRQAQLGMPERRRQKMAFLKACAYLPHAPESLAEIVPRALSSNPVDRPYFCELLRVVEGEKRILDAAHVLGYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXX5</accession>
    <name>A0A914HXX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4803.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4803.t1"/>
        <property type="gene ID" value="Gr19_v10_g4803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037938685" evidence="2">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4803.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38068" checksum="21BEF5011CB68998" modified="2023-02-22" version="1">MLIELKKVFLKYILSFFVLQTLCVDQNEKEVGQILLDLKKGDANAFGEVQQKFKAISIGQSAEEKPKKQQNDDVINNGGRLKGQKESPTNKVKQNVPSNSVSAVHSFPANESHNKIRFVSNFFGAPIDCNAFDKIAIKRTERRKMAEEIGANKSALLLAGRSVDSALISIELLLLPFAADLSTNFDQIFFTEKIHFVSEAMAKQMLCLLIEPISVKILLNVYIEILQKRLPDDILLVFLNNSSMKAKEYMRRVKLYLATITESCNARSNLNIYYQMYKVVSKVLDNVGTEFDQSIEMANVLYKTKAFVNFVLGAIKQFLRKASEIGFERIKSENCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXY3</accession>
    <name>A0A914HXY3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4811.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4811.t1"/>
        <property type="gene ID" value="Gr19_v10_g4811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037089859" evidence="1">
        <location>
            <begin position="23"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4811.t1"/>
        </source>
    </evidence>
    <sequence length="879" mass="103504" checksum="9E1FEF29FA988966" modified="2023-02-22" version="1">MISRNLHLFYFFFSLLSKFAFLEIYGMDISQLNDLYIKLLFGDLTVADQSDLTCRLKLGIKQNLSLGKLCHLWQVEEFVNYFKGELEKATTTKQFENPEKTMRERAFHNCADLHQILQESEQNADFQPPEWVVKFRWHLSGMHFYALDAMIKADEDKMPVWFQNGRLDGETAFSYLLRLLNVQGVIAKISGAKQRIVHNLLSYDQLRLLELIHPIRLGAGFVDEATMREYYGMLFCQADDQIADFLGLWKMFFKVIGEVGIVEQNDKIVLKKRKDLLTPLNGILHLLNSANERKTIDEHKKSAVFRKCFGEQVQMRERFKGIFKRAAADGNEEIGQIVPDQFWNIFEEKQNETTLAEDRSQNDDVTFTITALNDVCPDKHISLEQLKEIDRNRRPNDPDSHILMEQYIKLLWEMNGDEPPKNMDKDLLRNVEMRAAIFYYRNRVAQLYKHGQFYFQNDHFVDKINTYGFLKLTDRQNDKKLEQKMCEIYQFIYKIVRDQELMEMSDGWKSLLTKNVEELATTTTNEHVIIGQIYLLPQHKKQWHQIDCANELSANEFVVEFQKNGHFFEIFHMFALIDLISTFDQIRSFFCHGTPLNITWLKHQIISLVSNNALERLEMLFPQVLHYDHLINTQLIHMLSNQFEFKSGTLEAENAEARGATPLLLVSIKKQEIKLPLCPLFVLYHFVEKFLHGNAFQNSKIFENLFTDECESSEKIKSALAENRMSFREHVFEFFNRNIEIFVKFVEILAKKAGTKTRFWKFLNSAEETKLLPDIKINWLTNALWTDQTTADVFNDETWLISHYSDFLTTTDSVEWLNLKLKLDLFIFVRWIDAKISFAIEENPIVAQRCFDFWIHNNFLFLQLYDRCSKKSCNLSSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY13</accession>
    <name>A0A914HY13_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HY13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4834.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4834.t1"/>
        <property type="gene ID" value="Gr19_v10_g4834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF58">
        <property type="entry name" value="BESTROPHIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4834.t1"/>
        </source>
    </evidence>
    <sequence length="477" mass="55775" checksum="8016BC218132102E" modified="2023-02-22" version="1">MTISYNLDISSSNAFTFLRIVFRWRGSVWKSVRNEFVTWTVLYYCVFVFYRYALSESGQKAFEEIGKHIDERVSLLPITFMLGFFVTIVFDRWKQIFQNIGFVDSPAFFICTYIRGETPQIKAIRRTIIRYLCLTQVLVLRDISIQVRKRFPNMESLVDSEFLELPELDLMEKVQNEFPKYWMPINWIFSICFDLRKNGIIETDLQMNTILQECKLYREKLQNLCNYDWVPVPLAYPQVVFLAVRIYFLLCLLARQYRLHENDGGENQVDRVVPLMTMLQLIFVMGWLKVAEALLNPLGEDDDDFECNYIIDRNIGIALTMVDECYDQRPPQWPENSISKNLKKPLYAENCAVYTQNPLVGSATLCNLREANEHVRMVQRRPSDMGRRHSSNLPSQRPYLISPKRLRFRHSLPIRPAELPIVLSTGWYENASPELKQSISPSPSPAEVRHLDPVKEDEEVEVNAITTEDNNGTMPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ09</accession>
    <name>A0A914HZ09_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g510.t2">
        <property type="protein sequence ID" value="Gr19_v10_g510.t2"/>
        <property type="gene ID" value="Gr19_v10_g510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g510.t2"/>
        </source>
    </evidence>
    <sequence length="426" mass="46546" checksum="345BF9534DCEE4A2" modified="2023-02-22" version="1">MDYFSEDGEEKESAPRGENCLGDISCLTWSAVCEGEGHEQCAPSVVSDFDAVLDRKDALGGKRVATPLQALFCAFLLRRCGSTTNSRRIVTTLVGSNGGDEFVMFLGSRGDSVPVDAFPSPRDLTEALEARVRSCKVAWRALADSGFHPLHLEPPPLPFGADCRAEHLGWTTLFGQASWALETLRASLVHRRRLIDVPRVVFGDSSAAQITQNAEMTAVELLTSEEGLAGAIRALDDVVLSGKVKALLIVIGRDALLANETSETMDEHLGRIRDICSRYGHVFILWAVPPYVHVRKLQYEEFVRSLARLVSGTKIRLGHISEDGRSLGEVFRYGATFAGHRVSKTGLMTEHGAKAMIAWIMDVGKFPGERELGKPRPKSQVVRVAPILATDRRPNRGRGGGLGLGDHRRLDSSRLARLAARRTVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZY4</accession>
    <name>A0A914HZY4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZY4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5333.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5333.t1"/>
        <property type="gene ID" value="Gr19_v10_g5333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5333.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="6892" checksum="323F9DA4E6544232" modified="2023-02-22" version="1">MEEGKPPSNGRADGRTLSHFFVTGTELAGTELDGVGSRRRDGVGWDGVGWDGVGGTELTPTPKMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0E3</accession>
    <name>A0A914I0E3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAB6-interacting golgin</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0E3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5449.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5449.t1"/>
        <property type="gene ID" value="Gr19_v10_g5449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097355">
        <property type="term" value="P:protein localization to heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057603">
        <property type="entry name" value="Periphilin-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028851">
        <property type="entry name" value="Pphln1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836">
        <property type="entry name" value="PERIPHILIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836:SF4">
        <property type="entry name" value="PERIPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25234">
        <property type="entry name" value="Periphilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Periphilin-1 C-terminal" evidence="2">
        <location>
            <begin position="330"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5449.t1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46391" checksum="6F4492018EE02EA5" modified="2023-02-22" version="1">MSRSRSAQSHSRSRSLSSMAEGRGVGGGPASHLDREKSLEYCDFDVKKERLSPLRALSPSPPPKKSKREKRKKEKRQRRSKHLSPFSAEYRQPHSGSDMEIGGEEDDEGEANGRKKLRHETSPKVFIGPVQPIVQPPLQQQPHVLVSPVPSPFYQRHLAGAAAATNDAMLMKQQQSQLLNAPLLSHQKTQMIPKVELRNQSIMLDLSDPKNVSPPKFKPIGELVGYHHLNGSNEPSNFRTSSPPPPSQPMLRNLPMPTVTTNESPSVTANFFNPMTIQEPGLPLNNFREIQRAILQDVRYKAQEEEEDHIGHLRLSLLSRKGLTEEKREEKIAKMTPELRERISKRKRQLELSYRNDCEAYGLVVNKLIAKDRSLEERLKVALLETMKDLETETIKQLDEFLDQLSFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1L1</accession>
    <name>A0A914I1L1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein MEAF6</fullName>
            <ecNumber evidence="3">2.7.1.137</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphatidylinositol 3-kinase catalytic subunit type 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Phosphoinositide-3-kinase class 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914I1L1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6654.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6654.t1"/>
        <property type="gene ID" value="Gr19_v10_g6654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="21">
        <location>
            <begin position="199"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="20">
        <location>
            <begin position="542"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="19">
        <location>
            <begin position="879"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="686"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6654.t1"/>
        </source>
    </evidence>
    <sequence length="1166" mass="129740" checksum="4F848013DAB96BD1" modified="2023-02-22" version="1">MTNARADAKREMLELIKRRTDVSITLANLEKQIYNFETTYLEEAMEHGGNVIRGFSKLLESVNGAAGSVSAVSSASNIFVSTSSNSKQKKVPKQQFTEMDRIFSLSSITSPISSRLLELGTGIVSSADANASNGLPRDNFLVNGDKTLGRSSHSARSSQQRPRKESSQEDLTAGEPSDEDKMETADMRKEFCYLFSSELDVSVRVRLVSLSGYLPPSNDSVHRFVVPSGCMFARLTVYCNGRAVGRSVQTSFRQQTNASAATPTRDIQKWDEWLTLPVCYSELSRDAILHFTIWEVGNSIEPVLVAQCAKQLFSKHAIFRSGLIDLTLDVVAPQPNSADKQKATQQVQSVHPPVPMMMATNNARSAEQSEEADDSTPLLQQNKKRTNDMPGSNKRNFQFGELLKKEKLYKQKFIDRVDWLDGITFARLEEIKQEAKTEDRSLFLTVEFPAVEHADDPAPYSIIFFAEDAPREHENVNGDHSDGGDLDSDPLIPSLRSGGVSTARRGGGAVRNGRVVDPELDMANLCEIKHNMMTRNARAMDIDRRLQPNPTVRDALESIIKSSSCQPLLLEERDLIWKFRFWLKSNPKALTKFVRSVNWQAKLEVRQAIQVILEWAPIDACDALELLSPHFTHPFVRRYAVSRLQCTSYANILLFLPQLVQALRYEPPPPPAKVDQQQHQEDDLMIVEGGGGSSGGNNTTSDNVLPNQQRQQQTPGTANSVSSPTASMMFGPMETMAMFGAQESMDLATFLIRAACENGLIANFLFWYLKVEVEANAADSDDTASSSSVSSMYCLVMGRLKHELSKGNGTARHTLSNIATQKKFVDTLVDIAKAISDLSANRTKKQEVLRKKLSENADLTELKGLSLPLDPSIHVRAVQPESAVLFSSNLMPMRLTFSTVRDGLTPYECAEAYTTIFKRGDDLRQDQLVLQMIRLMDELLKEDKLDLCLTPYAVLATSCSEGFVQFIRGATPLADIKSIQDTLRTFRPSSSAPYGIEADVLSNYVKSCAGYSVICYILGIGDRHLHNLLLCENGKMFHVDFGFILGRDPKPMPPAMKLTSEMVNAMGGQNSEHFRAFVNYCTTAFCILRRHANLITNLFSLMLDAGIPDIAVERDKAVMKVLERFHLQLSDEEACHLIVRLIESSLSAKIPIVMDFVHNVKQFISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1T3</accession>
    <name>A0A914I1T3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1T3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6095.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6095.t2"/>
        <property type="gene ID" value="Gr19_v10_g6095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000052">
        <property type="entry name" value="Lysine histidine transporter-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6095.t2"/>
        </source>
    </evidence>
    <sequence length="432" mass="47724" checksum="3A7CE1761F539DCC" modified="2023-02-22" version="1">MNEIARKSESVDRTSSGLHWALAAFFMVTDMSIGGMVSLPGPIFRIGIHRGLALLVLFGILSCCSAILLGRCWQIVLHRFPEYRQKHCRRPYAEIGFCALGQWMRTLVSIGVNATQFGVATVFLLLCAVNVRNLLHVLFRLDTSECLILLVLALLLLPLTLLKSPNEFWPILFGGLFCTVATFVIIFIGTLVDLFKPTKSSISNVSSAESSDFNNYLNAVGTMLFAFGGHPAMPTIQHDMQNPADFHKSAILGFSVITFFDFLVVLFACFAYGDGLSDSVVGSIRTAGVQQIALGLITANSLLAIILVINPLNQEAEEFFRTPQEFCRRRVLVRSAVLASVLFVAESVPNFGPFLGFVGSSTVPLIALILPFLFHLILSDSETQRQRRKMFIWARRAFYGTVIIFAAFVGCFATFSSLQTLFGAHFLMPCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I269</accession>
    <name>A0A914I269_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I269"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6186.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6186.t1"/>
        <property type="gene ID" value="Gr19_v10_g6186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037755385" evidence="1">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6186.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9134" checksum="A4831A732EFC9F2B" modified="2023-02-22" version="1">MNLRYYPILFFVFFLALFALADGVKLGNEPDDGVDEEALDLKPAPASKVLSRAQRIARRCTRCKRGRWSWSSSNWDGPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2V0</accession>
    <name>A0A914I2V0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2V0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6102.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6102.t2"/>
        <property type="gene ID" value="Gr19_v10_g6102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6102.t2"/>
        </source>
    </evidence>
    <sequence length="138" mass="16291" checksum="D176DA4861C3AADC" modified="2023-02-22" version="1">MSQMNSLSVLFLFCSDLENRTGTEQEQNRNRTETEQNRNRNRTGTEQEQEQNRNRTGTGTEQEQNRTEQNRTGTGTEQEQNRNRNRTGTEQEQEQEQNRNRTGTEQEQNRNRTGTEQEQEQEQNRNRTGQAGTGKHWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I301</accession>
    <name>A0A914I301_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I301"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6846.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6846.t1"/>
        <property type="gene ID" value="Gr19_v10_g6846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6846.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29799" checksum="66D0DD40A7AC1DE5" modified="2023-02-22" version="1">MKSRKISSASSHYGGAISVVEPKNPSSSKNASQGFESQSMEWDFSNPAPQFIQAPQIAQQSSNFISDNPGSSTSASNRGKSTNSGGGSRKITFKRFKNDPRAMALVEQHNNNEITDTALSEALEQINHKMSTKAMYLYLNMLNEEKKAGSGAPNFQDTQIAGQSYNFTSDNPGSSSHYGGIVPSQQAPPMDGTLVPSQAGNHSNCTTILQFYIGQPRLIGKRKKHQLFKSTEFWQLVTFFDYRFCVEFVRCIPSRTPISTANAGHIISSIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I319</accession>
    <name>A0A914I319_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I319"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7039.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7039.t1"/>
        <property type="gene ID" value="Gr19_v10_g7039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7039.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13450" checksum="8A1D49495071D2A2" modified="2023-02-22" version="1">MMKKKVIGPTGNMASFIELIPAMLRALFNGAREQWRRRRAGERAVQTRSPLPARAQACPPARNGRAPAPPMVADQALPLEEMPPEDAALMDVLKMNITRKQNEQFNNTKKIYYSFQIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I324</accession>
    <name>A0A914I324_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I324"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6370.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6370.t1"/>
        <property type="gene ID" value="Gr19_v10_g6370"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6371.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6371.t1"/>
        <property type="gene ID" value="Gr19_v10_g6371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6370.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6371.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14968" checksum="7AEA69BC40349442" modified="2023-02-22" version="1">MIEHGLPEDRERIVRTSCHVIGMALELVDKASQIEIINEILAQVIPLSLHKYGSWVIECVLEHCMEQQKRLASHTNYGHDPTAHMIEHGLPEDRERIVRSLQGDIMKYAQDKFSKLSRDRNGVGIGGQSVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3I6</accession>
    <name>A0A914I3I6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3I6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6543.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6543.t1"/>
        <property type="gene ID" value="Gr19_v10_g6543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6543.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21226" checksum="0F1BAC3FEFD590EA" modified="2023-02-22" version="1">MAGELVATGGTSKLVTEPSQFSRDFGAIRKGLYKGSAFGGIYEIFCWNGISHSGTDRLWMSGGCAMLRIMVGRRFRSKIGMNGEGLFAECAKVAFESSLRFGGFFHEFINETAKSRAIQSPKLMTDCSKMSFQWDGTSNFGLAPFFQSDQMARNCARKSLQFCYKSNSLSPKSVTESLRFSRDFGSMEMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3L2</accession>
    <name>A0A914I3L2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3L2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6292.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6292.t1"/>
        <property type="gene ID" value="Gr19_v10_g6292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="3">
        <location>
            <begin position="41"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6292.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26385" checksum="6890087D5FA1C3B7" modified="2023-02-22" version="1">MGVSPASAVSTAMNLFSILTLPMGPKELDQDMAKINSQMHDLVPKLFVGYDRTVPPSAKNGGPVEIQSLLVVDHIEELNDFEQTLNFHGTLMMMWRDERLIWEAEDFGQLGSLAFTGFDLTRFWWPDIVIKGITMPSRQILMFHNGIYTLKSSGLIIAELSVSIKAACRIDLKNYPYDNQTCFIFLFTPAYPAARVTFTTSSAMYSKESLQGSIGFSEQSVNEDRSNILNTTMAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3U4</accession>
    <name>A0A914I3U4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3U4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7249.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7249.t1"/>
        <property type="gene ID" value="Gr19_v10_g7249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF326">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER SNF-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7249.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26622" checksum="B7D3E5E10F780815" modified="2023-02-22" version="1">MCTRSGIFYFAIFNDYSASFSLMLMLILEIVLVVYIYGIRNYLADLRLMFGKSRHLLGKLFGPTGYYIRFVWLFLAPLQASVIFVFVLVTQIGHNLTYGKEKRLYTFPAWANGIGWMISCLPLLLLPLLVLYNLWKFARKGKTWHELFRLQPKWPSYGGGRHSNTTTATAAVANQTAADCSTTAAQFKLSERNGGGGAGTGRPPRRHRIVPAATFFANGKRTETTTAAQTRAPCTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4T4</accession>
    <name>A0A914I4T4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4T4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6616.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6616.t1"/>
        <property type="gene ID" value="Gr19_v10_g6616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6616.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10753" checksum="2206B72FA8CC2AC3" modified="2023-02-22" version="1">MALLCAATADCIVPIGQTKEGPYTKIAPNLTTHRHDQSLLGILRYNMEYRHQIQDPSFLPQISRDHPGMNGLFYTNRYQTFGGSSADWLHKVQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I576</accession>
    <name>A0A914I576_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I576"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7003.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7003.t1"/>
        <property type="gene ID" value="Gr19_v10_g7003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF47">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7003.t1"/>
        </source>
    </evidence>
    <sequence length="434" mass="46111" checksum="2E997445FC094181" modified="2023-02-22" version="1">MGQSLSSILPKSVASDATRRITHEFFTFVLDGDVDQLNELIETLTDAELERLLHMKFPPDGDNRGTALSIAVIRGHTEVVAVLLDEGANPLEPSSAVVDNNAERVLPLLYAAAGGHLKVCRQLVTNGADVNRGRDNGETPLMLASFKGHLGIVIFLVEKGADIDLADTRGTNPLMSASINGKANVVQFLLSRGANTHQRDSTGTIFALVCAIGGGHLEVCKKLVEAGADVNQESTNGLTPLMYACTMKEATIAALLVRYGAIINLLDMDGHSALMFASKAGAPGIVRFLLRYGARAGEADNTGNIFALMCAVGGGHLEVCRELLMARADVNQVTSVGRTAVMYACALGYTDIVILLVENGANIERVTVIGTTPLMFASKAGSVDAVRYLLLMGARTDRVDDRGKTAMDFATEQGHVEIVEILRVAANQQANPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5D2</accession>
    <name>A0A914I5D2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5D2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11047.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11047.t1"/>
        <property type="gene ID" value="Gr19_v10_g11047"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6771.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6771.t1"/>
        <property type="gene ID" value="Gr19_v10_g6771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11047.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6771.t1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38724" checksum="67DD6806148F7FBF" modified="2023-02-22" version="1">MPSVHISLSACSTVSSVGRTRRRTANRPTANQQLTTWHACVYCLYKRPFSPVKAIIRLVSAGTDNNWTMDKSGSSQNNPKKSGALAQSNSSKIRLAPPKTIDWAIGTLEGCKRKRCCGVALDADVYFHTAHEYFKSFTKCREAKGHCDAKLKQHEQRRIELLEKLRLLQAAFSRDAQEKEAFREKNVLLLSENVNLRSQLHEQQTLGVRLQEKVQALADDMQGLQEKVDELDMRCTGFKEEVEGKEVEINKLRTSMAAVEQKNQQRDALDVSKSEAKPEAVVAQDVKGHALLASKRRSEERDNDGEITFIGTSKRSKSSETTPGTAVAAAQPLNSSNSTAIDQPQMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6G7</accession>
    <name>A0A914I6G7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6G7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7345.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7345.t1"/>
        <property type="gene ID" value="Gr19_v10_g7345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036827271" evidence="3">
        <location>
            <begin position="22"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="414"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7345.t1"/>
        </source>
    </evidence>
    <sequence length="759" mass="81750" checksum="C605759E7DA5355A" modified="2023-02-22" version="1">MILSPLISFCCSLIMLRIIKAKEPKQNDVTAANGTNFAQQSPRLRLADERPSFTNELQNTQLFRSARNSLRFRAASMPSNEDRTQDEVVRLKNVAKEVEEKLGLSPPRLNSNRQGPTLIGPKRGELIPAIESPGLSLRRLIAVGDGAGGLPRTRPTNPLFAATLLRQQQRESAQTAKFGINPVVGSNFIGKQQQLSEQQQRMVQQQQFQTLFQQLATIQQQRQLQQLLLNNQWQNAAERNERLGASRASSTFSGNVENLAPPGFFGAGSGQTSVALPGKLALTGIRSVGQPPAATASFLGGIQPIQPPPIAPPLQSSSTDLADLTALLQKMSLNNPTNPSSSSTVLGPIAAVLPNAASPQVTPQQERPVVVKLVTAGSEQQQQNTNNNNNVALQQIVLQEQQRFVELLEREQYREQLVQNNRKELQAVQDQQQRILELLDAFEREKEQLEDNSRAIRRTALERNKAIAADSATSAPTQQQSSADTNLLKGLLQAFSNIITPQGTPSGTASSSTSGQPLPNIGPNLGGQVSQFLNQLLQQPSTTVDQSQLLVKIPQQQQQQKQAQAVQQPAVQYVSLYDPRVGQQQQFDAASLLVGGDGTVSSGLVQPQQQVGAVFQPQQQVGAVPQLPQQVGAVPQLPQQVAAVSQQQVGAVPQQQVGVVPLLPQQVGAVPPSGWLPVGDVLSGGNNGQQQLLANGIVQRAQQRQRQDVQQPTADGTAANGQTVDEDNVEEVGEEEKEAGLEDGRWTASADGGGGLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7Q2</accession>
    <name>A0A914I7Q2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7Q2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8265.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8265.t1"/>
        <property type="gene ID" value="Gr19_v10_g8265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF8">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8265.t1"/>
        </source>
    </evidence>
    <sequence length="611" mass="67009" checksum="FBC2FEF121889125" modified="2023-02-22" version="1">MPKINNFLSVSPTALQLGARLSVLGTVGAIRPRSSSLRSSRSGAAAASFFMRNGGGSFDEEGRCMICPLREQPAAKVSTASLFPSQRLLPDSNNNSMCPPAVGDGAPPQSRRNSANEVANRYVSYAQRWIVLSAVCLIALSNATQWISFAPLHVGVGNSGSTKFKRHCRLVRRRALEFADLPIDRFGIRISCHFAAALNLAGAILRVISSIPSLDRHRRLPVLYFGQTVAAMSQPFFLCLSPKVAEHWFGEHQRALANSLSFIANPFGVVLGSIAPVLFVSDAKDSSQIYYLNVSLLALALAVSALTLCVSRAQPPSPPSASSHCEHKPDFARGLQILFRSRIFYIQTLTFGMAFALQWSIFVTADKYFSRLQYPDKLGGYLLSVSAFSGTLASVLGGWVVDRTKKFNEFIKAAYVGIAIVGAALNLFLRHPRQSPLDTVVLSVLLTLLGFFAVPVFPISLELGVESTFPVAEATSSGLLIISGQLQLFLLTFGMQFLESKDWLYHSEANGNFQLSVDLWTLFAVLSAVYSCVFLWPRYHRMEYEQNAIFRHLLPPRLDEIAGDQSAAPAAMANTNRILLFPFASQTMQNGRELNDKRKKRTMAPEGRGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8X5</accession>
    <name>A0A914I8X5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ING family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8X5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8590.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8590.t1"/>
        <property type="gene ID" value="Gr19_v10_g8590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000021">
        <property type="entry name" value="Inhibitor of growth 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="202"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="113"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8590.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31572" checksum="27F76E288FA9597D" modified="2023-02-22" version="1">MADIYEKCLKNARPIQQKMEENLYNIRILDATIKQIEKELKQKLNQMANTLKKTSKDERRRQYEAIEKLYERAKNLSDDKIRLAESNYEMVDVFIQKLDKETSSFNSYAECVQQSNGRTHSSAGTSKESTEVKARAEEQQPAVNRRRGTAPASSSTTSSQSLKKGTAGRTNAKEMANLVKNEATEPDNIGAKGDMPIDPNEPRYCFCQQVSFGHMVACDNKDCPLEWFHFDCVDLKASPKGKWFCPKCRGDDRDSTRRQQQQTKTPKSGARGKDIPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9W5</accession>
    <name>A0A914I9W5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9W5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8032.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8032.t2"/>
        <property type="gene ID" value="Gr19_v10_g8032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="185"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="275"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="361"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8032.t2"/>
        </source>
    </evidence>
    <sequence length="761" mass="83880" checksum="FFC91A9827DEA22F" modified="2023-02-22" version="1">MKHLLSTGNGADVHFLVGGWRQKGASTSTQNNLGDGLRCRRWDQLPMIESFILLVIFLFRWLSWRARALMALHSPALLLLLVLCILWTIFCDGGGGDGGGGGGGGGGGGGGGGGGGGAAADAAVAPRVYAFQREKRRRMAAVARMNDANAQQQQQAGAVALDAETKLSHSSDGVETCLVDVLFAPKVRVETIPEGSQVFEGGYIRLHCTSDAHPDDVKLRWSWDGEPKRLEVVDAQTVLINGLRFNDNGRRVTCTAENTIGVGTGVFELDVPSGPRFMSTNQSKVVERGGQASFQCEVLGNPTPIVRWYHGRDMDIPIEEGKNITIADVLDWKEGEYRCVAEVDGFPPKALHHMLFLKGPPKVQLSEQFLFDADSVTLACKVQHRSERVKVHWYHNGHRVDIEPRVHLQQQPELDVVGDHQPHYAVRDERMSRWEIVSRLTILRFTDADFGTYNCTARNEHGVVSDQREITLNVVDSLRWFVNKTPMEARIGVGLFTLALLGIACMACCCCIRNWHRRRCGLSKFSKANGDFTVNVEEVDNGTNTSSSAPLCVQQFYTPDFHFTNYSPNNGFIPHNQHQQYGGDQFILMPNGGGGVAAATDPQSDVHQQTFCSSYQSFGNGVGSTFGHKTVNNNNMLPPVLSPNSFDGMMALDGTTTTVPGTMPFSNRSSPQYYQQQQQYGVMETVPEEMLRTPDSTASDNRTYLSNGGNVLMLMGRGGEQQQQRTFSRNSTHDNHAENRIRQLARRNCSTVTGLIKNNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA05</accession>
    <name>A0A914IA05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IA05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8879.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8879.t2"/>
        <property type="gene ID" value="Gr19_v10_g8879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000045">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="85"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="288"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="632"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8879.t2"/>
        </source>
    </evidence>
    <sequence length="721" mass="81643" checksum="AE49A461938333BF" modified="2023-02-22" version="1">MRAAYAYEENCFWPTAKSRKVNGQNCEENKRTWRGRTNSKMPSLPILLFRLLLPVFILFLPLCLAQRRSVPIPLEMDRMLGAGREVYDKQSTPTQNERIPTSVKLAMYIEGIGSFRTHTMDFQLDVYLQQFWKDPRLAHNESRILIRDKSILDRIWHPDVYFANARIAQFHEVTQPNFLVWIEPDGSILYDTRVSMIVICAMNLKNFPLDSQWCHLRILSYAYDINHLLIEWVDKAPITKNTNITMSDMDIVKLVPGTCDGVYSTGVWSCVTAEFFVSRELTHHILQTYVPTTLIVVISWFSFWLDVEAVPARVSLAITTLLTLSTQANSVKNSLPEVSYMKSLDLFLAVSVLFVFGVLIEFTIVNYTQRNATMAAAGLLTDEKGGGRNCALWRCLRKTLEGKWKKRKWNLREDNQQKHHKNISRMAAAPPAQKDLEGGLMRGIRWRNDEPQANTTKKISALQTQHQLRHVLSSDGTKEAVVPIIVCDKGDNNAEQYTLQKTMCHPPRMVVDRREAARIACWASPELSCERLSLRARGPQTPPEGETAAGTGADEQPAAPTEFCSSSSPTSSTLSSCAVLLVPDLPQPPPSSAVALCNETVLPLNSLLIRPDKPFFRRASAMASLLDPINIGNGGSKTDQQQLKTDNLESEGKTAPTARRKQPSMSSQAKWRHAVRKLQMNKREAGRIQAKKIDAWSRWAFPLSYLSFQGAYWYYYLRMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA68</accession>
    <name>A0A914IA68_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA68"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8320.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8320.t1"/>
        <property type="gene ID" value="Gr19_v10_g8320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF151">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="28"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8320.t1"/>
        </source>
    </evidence>
    <sequence length="575" mass="65856" checksum="92FE1C558CA4A7C5" modified="2023-02-22" version="1">MFRDDAMANFERWLHTQQQRGDGQLLWPKVELRRPVDDESMGYGLFAREDIRLNEIAIKVPERTMLTAGMVADIPEYAYIMERVQLDPAEVLALFFCFERVHFDCFCEQSADGVPFLVQWEMDIPPGFARFIQMRKSRRPHQKSADDDDEFWWRPYLGILPLRFGTPLFRHFLRGDDFCRLRRVADKLPQEAKSKLLGQLAELRVLEKKLFNLLYPFSNCVQKANGRRSLEGETFDASNFDKLPRESIEFWREMCCWAWHVVNTRCIFLTTAIPRGTMPAAAADSNGGRVGGCDGRWTAGGQKIFQRVHIQLPITVTTTDRGEEEEDYGGSLAIVPLVDMLNHSTDAQCVAMFDHKHSRHYLIRADQHFVPAGNQLFVCYGAHDNARLWVEYGFRMNAWNPFNRVAMPQDLFIALAERCGVRVSDRRREVLGKANLCCTIYATDDEPSFALRKSCTILLLEREKLQNWSQHIFGDYFGEGQPPPPPSPRGEMKLLGSILGLLQKALEGRKANCCVAGGDEDDDGEEEEETALLCSLWDDQIDIVRRMAAHLAEEDKKTIDQNAEMDEDTGGRLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAP6</accession>
    <name>A0A914IAP6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAP6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8224.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8224.t1"/>
        <property type="gene ID" value="Gr19_v10_g8224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8224.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26117" checksum="5408CE698F92C02B" modified="2023-02-22" version="1">MVFLSQKCIFSLVTQDNSEVVVPADFVDQSEMLSNYAKTQPQENGAEEEQQAKFVMTDKAPFTNKFHLEMIFEFLRLYKREQPHETPEEGASDVRLGKGESNSEEPNFESTMPEWALDLFSKQSKNDLFLTMNSANYFGIGSFVTFSAAFVCFQIMKKGAEEAAEYLNLELDPNSAEEMRKIMGEMGEAREEQAKQEKAKEKKEKDEARRRAEAEARAAAELENEKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBU5</accession>
    <name>A0A914IBU5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8761.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8761.t1"/>
        <property type="gene ID" value="Gr19_v10_g8761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="221"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1332"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1395"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1474"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1565"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1686"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1334"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1353"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1567"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1599"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="316"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8761.t1"/>
        </source>
    </evidence>
    <sequence length="1747" mass="199379" checksum="8D65A6DDBAB7D026" modified="2023-02-22" version="1">MSSLFQHSARLTLTQRQLSSIIRPIPAPNGASPKQSERMAQIIARSAPIAGLEEEEEEEVVEEEEEEEVVEEEEEEEYSYEEVDEEEEEQEEMTEIEPEVKRTSAPLTSAESVGRDGTAGGKDRFSNLEDECRRLLEVPEEALDREAKVKMEPGWDSRFWVPDAQEGFKLCEVRTKRGDRQNGEETETEVEVLLLNEEEQLRELSRKSVRRECLQRLSVSHLCENLCQLSELNDPSVLGSIRQRYSLRLIHTYSGLFCVVVNPWRSMAPLYCGEMRAHYANSDGDLPPHVFAIAQSAFEGVSDRNSRTNQSILITGESGAGKTENTKRIIEYLMDVAERHSNAKCFDQKRSATIEKALISAGTALEAFANAQTVHNNNSSRMGKFVRIDFDRGGKLHSAQIDCYLLEKSRVVSQNAGDSNFHIFYQLLARADFLQSEKASRVLCRIWDYRNPYSGDDPRPEAFRFLNQGRTADSVHAKFVDHLEGGRETEFALDQLGFSGPEKGWVRELVIACTIIGEIRFGERQGMDISFVEEMAEVEAVAELLGIRAGALVDSLTQPTFRVGDALIRRSQPLRKTLCAAQSLAKCIYERLFAWIVSKCNLAIRGGRQGAVDELSLAGGNKFVGVLDMAGFEIMARNSFEQLCINYTNERLQQFFNEFMFVREQEEYRREGISWEYVKDFGRDLQPTIDLIEKPLGMLSLLQEECIVPNGSDRSLLEKFVRRLSSTTPGGTFFKARQSSRTPCHHHFTIEHYAGPVSYSVDGWLEKNRDAMDGALLGVLATSSHPLAAQLFAGRESTAKSSADNKPSSPRGCAHRGGSAMAQATISHVYREQLAALLRTLRDTQAHFIRCIVPNHQRHPFVLDGALVMHQLRCNGVLEGIRICRQGYPNRIFYANFLARFRLLHAPSAALITTNPRDAVQQLFAAVGIVPSRYQLGRSKVFCRVGLLSQLEALRRERLNDCVCKLQAWIRWARARKDCQRRREEWLSVRTVQCSVRHFVHVRHWPWFRLWLRVRQLIPLVAERRRLDALEEANGKLNKELAETKRETERARTELRECAERVERNEVQWESDRAKAAELSAELKRNEELLERMERKFDDQHAKIVRLNGTLGEHAKALERLEEEKSVANAELLTLRERHRLERIERESAEEALRLAQEECVRSRVDVDEMGTEVRRMRSEMCRREEELGQSRERTREQQAQLADLNRALAEANDRLGEMQPQIYTEKSARRKAEGLVEHLEAELCRISDEMDKANVRRDAMKEQIRVRDAQMRKLERNLEDKSAQMEECVQELKRAHKRSQNEVQEHLEECRRKCLRMDTENAQLKCKLESQVRDNASQLQTSQSRGRLDKFGSSSALDSPGNSNNNNNIRESSVDSDCGGGLCRSVTARHSLHNASSANYPGSLHRPHRSYRTSTASTVHTEPFSVGVRRSASGTSTVNNLSSVTTSSSSVLRRHENATANSMLTSLTTTIDSGLLTRSPSSTSTVSGTHQQQQQHNSAMMAQRLDGAERRVMALERELQQQRQDAQMARRELEVYKQMARRELEDSERTRDSLSKQLRSVNAEMESMRNDLKKEQEQSQTTDFASRKMRGENNALRQRLEDEREESRAAIAAERKKHAEKADELANEYNSRLRQVGNAQRSTEQLQTKLTETESQLDRAFGQLTHLERLQKTQNSIGETWETQYRTAQSELQSVRDENAALKSKMRRQQRQIVLLTQQSELDSRVNELEERIGTLGGTTANREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBV6</accession>
    <name>A0A914IBV6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBV6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g877.t1">
        <property type="protein sequence ID" value="Gr19_v10_g877.t1"/>
        <property type="gene ID" value="Gr19_v10_g877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037621333" evidence="1">
        <location>
            <begin position="22"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g877.t1"/>
        </source>
    </evidence>
    <sequence length="583" mass="66734" checksum="E13E6A68985B2681" modified="2023-02-22" version="1">MGEMLTFFFIALLVNFGETAATPDEDVRQMLAELKIVSGPTMDVASMLKKVTKVSMPFLQAIHPVSNLAAAGMKNVFKPTTDEFEAMIYLNRKITETFAEMDLNIERLRVSMNCDYSLRKYGNVVTLNLDIIEPTFLRVINPENHPPIWRDDFVRACNGVLSPLNTLRWLNLRVNSYCKMPTKCEAHIYSRINDLFFEIEGKVENDDAELRSPFYVQYKQNMIVALTGMSVKMANQKMERLRTLLLEPNVTFMYFKDVWERVKEDSSLQPEPEEKQCFLKEVIETNEYKRESLLNTIEIVRRDIARLVIIAGICANVSTDGSEEKVVELFDEINTLVVGMSNKMEKWFKRKLELAWPNVILSHAKERYGKYSHLSKYQFNVTARSVLFSANERGPPEYLHSVLITRSWGTQEWFWAPCAYTSGCAKAMNWRGTHLVITRHPILALDRTINAHQWLANVRENITDIIAANWKTDSLPWLLNQINASIGGGIRDPELFANVVFLHNSKLQADKCVIHYGIAGTWVHRTNLTSFERLRAVRAKRDELQGAVHLRAAKRDELQGAVHLRAAKLDQGALRTGLLGSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICE4</accession>
    <name>A0A914ICE4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICE4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8637.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8637.t1"/>
        <property type="gene ID" value="Gr19_v10_g8637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF729">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="12"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="13">
        <location>
            <begin position="729"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8637.t1"/>
        </source>
    </evidence>
    <sequence length="1086" mass="124179" checksum="57F34E60EDFFFF32" modified="2023-02-22" version="1">MARHWQARNTAAGVEDMVLLRQLADEAIVENLRRRLAARAMFTYIGPVLVSVNPFTQVAKFDEHEMEQYQGAAQYENAPHIFALADAMFRNVLIDRERQCVIVSGESGAGKTVCAKHIMSYLTFSSGGGQRVQRVKGTILQSNPLLEAFGNAATLRNWNSSRFGKYVEIVFGVSGEPLGGRISSFLLEKSRVVQTALGERNFHIFYQMLAGADAQLRQSLGLSTPDYFNYLNCSECFQAEGTDDQGAFAETLNAMNMVGLDNQLQLQCLTVVAATLHIGNITFVENDNDGFASVADEKYLKFPAFLLGLTVEDIKEKLTTRQLHSKWGTTREQVEVRLNQEQAAYTRNAWAKALYDRLFEFIVASVNCALDVDTRRHSIDLSVGVLDIYGFEVFERNGFEQFCINFVNEKLQQIFIELTLKAEQDEYQSEGIQWTPIEFFNNKIVCDLIEAKRPLPGIMSVLDDVCVQLHGQSEGADKKMLSLLTRELQGHEHFRPGTGCFIVRHYAGEVLYQIDGFCDRNRDILHADLVQLMLGSEHQFMRQLFVDCVSKDPNKKPTTASTKIRSQCNYLMDSLMRCVPHYVRCIKPNERKRALEFNEQRVLHQVRYLGLCENIRVRRAGFVYRRPFERFLWRYAILCTETWPHWHGEARKGCELICRSSELVETEFRLGQSKIFIRNPESLFLLEEARERKFDGFARVLQRAFRRFTAKKHLLKQKDEAISLLRGRKERCRFSLERRFVGDYIGMEQRPGLQAIIGRRERLHFAASVVKYDRRFRPTRTDLLLTCQIFLVEVVKRQILLTQLRAVSVSTLQDDFVLISVADSHCSLVETPLKTELLAALYKRCKERVGCSPLPLEFRDRFVVHLKAHATFPFAVRLIDGVERFVEFQLASGGGGIIGHQAAKTQLKTNGRLMVVTVLKGLSPESKPTGQRHSVVDIQRPMAPNGQWHHQRPMQQTHQLPPHHLKDEQQQKHLATTNGAIPQAQHALANVLQQRPTQQKQQQRAHQQTEHRPAPQKPPPLKPKPQVKPTGPMLRTLYAYEAQDTDELSFVKDQLIELVKKDDSGWWQGRLDGRTGLFPANYVSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEI8</accession>
    <name>A0A914IEI8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9482.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9482.t1"/>
        <property type="gene ID" value="Gr19_v10_g9482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF126">
        <property type="entry name" value="NA(+)_H(+) EXCHANGER PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9482.t1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37793" checksum="3A442F20BFCB79FE" modified="2023-02-22" version="1">MHQSADQFPARSMFISTTLAVIFFTVFVQGISIRPLLFWLKVKKSDFAGVETMMSNKIFQRYTDHTMSGLEAILGHRGSNSLRDTFERFNDNVLTPLLMRAEQRKTYDASPIMRAYRKITLHEALQLTQSGSKISKKTARIGRYRSQTESLPPATILHSVSRVGEQKMIDIDQFLSNRENVELLYLMFSRMLDRKIEEMQKARLDAGWEDDVKDDYMGIIGAQIQQVENGSICTQRLRKPTKFLLRRESSLPNRTTRLMMNGTMVDGTKDATLAARNGIEPTNRSRPHRKLSLPLPTRHLQWRVARQESERVNAWETNGPKIDGNKSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IH51</accession>
    <name>A0A914IH51_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IH51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9851.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9851.t1"/>
        <property type="gene ID" value="Gr19_v10_g9851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9851.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27228" checksum="FADE8CEA8E769FEF" modified="2023-02-22" version="1">MDPYFANLTNLIEKSVNASGQKAFLVCHSMGNLIVNYFLNRKVGKEWQQKYLNGTINVSAPWAGSLMLVEQIFSGNADRLQFGGSLVLSDPTVRKFLRTMPSSFAMLPSALAFPPNQTLLSLAGVNYSTKNMDAFLALTGSAHMAPLYHELTATVDAQKYTPMYCVHSNIADGVPIFYNYTNGIGNRPKAKMGDGDKLVNIESLRVCQKWMDEGKLVKKVVEIDGPTHMAILQEGTFYKAVESIMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GNY7</accession>
    <name>A0A914GNY7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GNY7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10086.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10086.t2"/>
        <property type="gene ID" value="Gr19_v10_g10086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150">
        <property type="entry name" value="PROTEIN CBG08832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150:SF7">
        <property type="entry name" value="PROTEIN CBG10108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037378617" evidence="2">
        <location>
            <begin position="43"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10086.t2"/>
        </source>
    </evidence>
    <sequence length="814" mass="85167" checksum="5E5489ACB7D0936F" modified="2023-02-22" version="1">MSSTIISRSGSAMCFFCCCNNFFKSVSLLQLVLLLLVNPAHQQPGTPVIGGVCSLDTPDVHIGGKQTQFYLRCEPSTDSAPGEGVWVVKSRRAGSTASKIPAATIVSQHENVHGEQQQHTRKMAQKGGVISSYVCDLVADAVEHGYCSTSENCLQPVYTDRTAFLQCDPTTRRWVKKHCQSGFNFDFERQACIAHTAKMSHHFRQFPKRTADVPNSQRAIVCTYAQCSVLEPCNVGSCNNAYCCSAAIGSVPKASALPRTPSLSNLEVRNKTAASSSTSSTTRPPAAIVPPPIPSILVIELNNNNNNDGADALLHVAQQQQLFNDDDVTSSVLLRPIGRHSNPLPAAQIDHCSSGFHSPIRCGGGGSGTHSDECPVGLICESATRFCCPFPPKQQLKKRKTAAVALPAAQWPRALSLSANDAKGNRRRMALRRHDRFGRKRFCAFCCTRPAQLLIGANANGQIMGGTNAIPSDQQLNMLICPTGAPALGPCAPGFCVAPMQCAGALCCAPPAVVPPPPPPVAYGCPGGLPALGPCIGGRCASPGTLCASPSNVCCAQSVPTAIPATVCPDGTQAAGACVNGQCGAGFTCNQGLCCTNSSQTPRCLDGSQSIGACIQGKCGTGYTCTTGNICCPSQLNLCPPGQTSVGQAVNGRCPAGYTNFNGQCCGAQSAQSQISCSVEDSFGRCDNNQQCAEPGYACDVANNWCCPQVIGDAIGPCIQGEGGNRLCPEGYACVGEGEGQCFRLDTGTCAPEEQSGPCAPDGSCPPGYECIEGFCCQTDVGAPAPTAALRFRQRRRRAVAPATAFLGMVRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GP22</accession>
    <name>A0A914GP22_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g1003.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1003.t1"/>
        <property type="gene ID" value="Gr19_v10_g1003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1003.t1"/>
        </source>
    </evidence>
    <sequence length="1724" mass="178142" checksum="FFE275254B0E938E" modified="2023-02-22" version="1">MSTQFESIGRLDMPEEEAEAVQATVADIMAKTSGTEISDRPSSESNSSSNEQQKVPQQHQKQIEAVQKQKQQRHHQIGNGTVPTVPANNNPPSSSACSGRRSPSADSERSLRLVIAESGGGTSGAESSPLTTPKPMADCGGGGGGAPFPLSGAAAASNSTGVTVNRPPAVGGTLDMAQTSAIVQSNVEEPKENGQISKTAEPLKEAEVQKESLSPTGTEQMAAKSLKLDEKSAGDESADAAQPSTNRDFGPVTPPPPAAVNAPPSLSPSPTVPDVTLSSTMPSSFCGGPTIIPKSTATTSASSSTATVASSSSNNTIVTVSIAGKSAASINAAAAAAAAAAATRSTATAVNSSATGGGGGTSTTAPAPPTLALMRAPIQPTPVTRILPRPTAKKLQQPKLPQPQQQQKSMKPMPTTASTAASCSTSTLPTMAITGTMTAAAAAKQTGVKRVPSTTATGPTTIFTSAKTTTTSAAQPQQQTIFVSGATTNKFAAVLPQAHSMKESKDSTTNASSTSNSSNSSTPTSTTIADTVNRVAAGAEISPPPSQQQQNTTQAAAATTVLSSSTAATASNTTTTTNSTTTTTATKSMMIVGQQQGGGARVQQLLKPRPPKKKKTAAVAPKATLPAIGGEGNAAVDEDQRNASMSVVELQQQQQQPSSATSLFPVAAGAMPASNGPGGGGTMLFPPNFALAAAAAAAAPNGTVGGGLVAAPYPTGAGGGGITHYFIRQTTASGHQQLIPVIPSQQQFFFSMPAGTTEMVESNNAVNASTTFQGQTSSEGMAVQQQQQLRNVYFRSGNDLFMPAMVSNGGTVAANANANLLASPAVSTTTLSQNSVQQNFVPPPPLRPPSVQQQQQQQKGGVQSKGTSTTTAAARMPIAPKGGQAGGEAPSQPPSALIIGAPHQQLAPAHCPPPQQQQQQYFLTSTGAIVTLQAPPHHLQLQHAAQQALGGVRILPATSNNNNINSNSSATVATTSSAFTAGGTFVDFYQPSAQAPTMTEQYLHKNGAGAVASIAPNTARSAANSLTAKISSPKRKRKMDEKKIAPAAATSVRISTNADPTKQQPPHLSHQQQQHQMPDLNAVVDEEENEPPPVLCRVVNRSEEEPSVTTQTVESVFQREAKIIRERMFDANGKKFGPLKHFIDGFEIEEDIEPFACEHRQLLDRLKREQAGLEAEIEERSSSKAASLKSATISPEKITEDVIKRKGRKRAATASSCASSPERSPLPAPPSATGNRTEEETVGSSSTTNQKTKQHRQQSHDATSATEANAGGTAHATATAAEAAAAVKKGRRRELDGLLKMDFGKHSPFQTSDPDKYAQDVLSSLALAQGVERSARPSVESSGGSTTGGGGAGGGGKSSKRDKHAKKPFSPPVSPLPESRSASAQSATATTTTTTAQKVRTGGEKASPSKPVSTANGGAGQPTKGTTLMPSGDNKLKTSPKDQRRSDGSNASEEGEERCLYCRRSFKEVPKDKDHVQYCSKACRKQLKAAKRMKHSGSLEDGLNNSGGMAGDESRSGNSAVSATTSHRRSDPSLSSDSSGQQQHNHITSPLGSAFSAMQPQLLSKRRLPVDQHAEQLMSMNQRLSGGSGAGMIAPFPPPPFGQSSPDQPPAMLAVPMAIRPAPGTPVPSPALIQYGTPTAMYFNAAHQMAVSSSAEQQQQQAAVAHAYHQQQHMLAKRNISRNPNTVSLFFCAVAAVAEHSRWPLIFFSDASVNTDSVHGQSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPN1</accession>
    <name>A0A914GPN1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPN1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10268.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10268.t1"/>
        <property type="gene ID" value="Gr19_v10_g10268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10268.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12277" checksum="BAD016A69F1C9D03" modified="2023-02-22" version="1">MGPPPPLFFSRHPICALLAAVVLFQILVFADWVDDVIEIVNQKMAPWHALLEKYERALATMESEERELSRIKQIIEKKIEMHQKKLKKLMLKVLGNATFQECKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQL1</accession>
    <name>A0A914GQL1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Annexin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQL1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10271.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10271.t1"/>
        <property type="gene ID" value="Gr19_v10_g10271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10271.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25896" checksum="4E3E4E722E904069" modified="2023-02-22" version="1">MSGAVRRQILRILGSFWSEMICRQLVARNGHGAEEHRPPQPQLGRAVGTAAEQPARWDTKSVRTNMSDSKNCSWYVPAAPADQPAAGWATKGLRTNSEVRCQSERGLVAQGVEEMRGDFEDLIIALMERPENTTQISCAVRSRPGRGTNKRILLIEMMTTRSNNQINDIKLAYCKMYGTELKMDIEKNASGSGGCSPMWRIRRHGRHLQGVQEMYSKSLGAAIADDRLENVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRG3</accession>
    <name>A0A914GRG3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10064.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10064.t1"/>
        <property type="gene ID" value="Gr19_v10_g10064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10064.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7781" checksum="FA72F53811CDA218" modified="2023-02-22" version="1">MAEVHVARGQALHRNLATLMIPRFGDDVAQLDLALDSKFICNKCKKQLKLDDICYCTDAKTKCHCNSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT03</accession>
    <name>A0A914GT03_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT03"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11004.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11004.t1"/>
        <property type="gene ID" value="Gr19_v10_g11004"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6815.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6815.t1"/>
        <property type="gene ID" value="Gr19_v10_g6815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324168" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11004.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6815.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7740" checksum="16DC9D0635B0D6FA" modified="2023-02-22" version="1">MNKFAAKISFIVAMLAFCAVVSGETNGERPVQAAELSEVEVIDPVAHLRAARGCTITYCFDKCPGRSHPNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTI5</accession>
    <name>A0A914GTI5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914GTI5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11079.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11079.t1"/>
        <property type="gene ID" value="Gr19_v10_g11079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="161"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="362"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="681"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11079.t1"/>
        </source>
    </evidence>
    <sequence length="709" mass="80655" checksum="F37D50B3F085BA89" modified="2023-02-22" version="1">MPYEHVQQINVNQAAPSSPFKTLNSSSDFLNDEIQFIADPFAPSSPFKTRNSSPDFLNDDELDNIYDHAQQQQRLSPLAPRNQNNVYENAQQQHRLSPLAPRNQTMYTNMYNTNSSNNDFRPQRLAIKCCCSARKVKRTCSKKLKDVFGFNYFRFKQKPAVVAALLGHDCFIVMPTGSGKSLCYQLPAVLHPGVTIVISPLLSLMQDQIVKLQSCRISCALLRGSMDTVEVESIYSNLASIEPTIKLLYVTPEMIGASIRLNGAFMSLFRRNLLARFVVDEAHCVSQWGHDFRPDYTRLKTVVEPFRNSKDKVPVMALTATATQRIIEDVKQQLHIGGCKMFTSSFVRPNLVYDVVDKSQANFKKVVDHIRKMYPNGSGIIYCLSKKDCEDVATMIGGGAQPYHADLPEKRRLDTQKKWMSNNIQILCATIAFGMGIDKPDVRFIIHHTIPQTLECYYQETGRAGRDNQTAHCILMYNFNDHLRIKRLIENDEPKPEIKRMKEQSLWSVIGYGENISECRRKLIISHFGETYDRANCILTPAPCTICAYLSTHGQMPSKQFDFTKEAVAVLDSVWQIKNAGVTYVADLFRGQLGKKTVKRKVDDNGHGRLPLFALGDGLSEQDCNRFIRKLVIEEYLHERLFTTQHNTVIGYLSVAPKGHQYMLKYRQDKASVERFNVFMGEPKPKQEKRRSSTNVSNATNAKQRKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTV4</accession>
    <name>A0A914GTV4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTV4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10715.t3">
        <property type="protein sequence ID" value="Gr19_v10_g10715.t3"/>
        <property type="gene ID" value="Gr19_v10_g10715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF250">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10715.t3"/>
        </source>
    </evidence>
    <sequence length="244" mass="27692" checksum="6A4ED6B803C7A35C" modified="2023-02-22" version="1">MPIFPAIYFSFISITTIGFGDLFPEPQNLFETMVIIVYLSAGIAIMSTLFNTLGDHLRRIHYLGRDFEGAPDVRVWFGGQPLTVRELVALVANRFEIPAERLREVLAELDALIRLSDHGTHATRSRHFWQNAEQKMDEQLQPPSPTSSINSEQQQMLQALSTLHRLTVKGTRTFHTPSLNSLSLLIRSSPNHNQNISSSPLIMYQFLTNCGRLAMSNKFTKFTQKRINRQMVAFLMSIISVQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU88</accession>
    <name>A0A914GU88_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloprotease TIKI homolog</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metalloprotease that acts as a negative regulator of the Wnt signaling pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="13">Divalent metal cations. Mn(2+) or Co(2+).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TIKI family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914GU88"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11253.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11253.t1"/>
        <property type="gene ID" value="Gr19_v10_g11253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14789">
        <property type="entry name" value="Tiki"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040230">
        <property type="entry name" value="TIKI1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120">
        <property type="entry name" value="METALLOPROTEASE TIKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120:SF6">
        <property type="entry name" value="METALLOPROTEASE TIKI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037087685" description="Metalloprotease TIKI homolog" evidence="14">
        <location>
            <begin position="23"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11253.t1"/>
        </source>
    </evidence>
    <sequence length="570" mass="62798" checksum="71D0AA31817B5310" modified="2023-02-22" version="1">MPCRYSRSFTFLLISSALFASAARPLSSPAPFEDSSALTKCTDNEKGRHSYFWTVQHPSINGTVHLFGYFRVAANLIWDSVSPEAKGRFSASNVVVFESDNEGIEQLAECIRQQKINETEQLSASLWERLDGYLNRSKEQSPIPGVQWGQVSTEWLLPFLLHVLSHRELSSVAKEDEIDLKLNKQATEQSKQLEFIEHVPELCNYLPSFSHPQLESAVEHLLDELEMTEEKGVDLQQSSTRRAVMLYGCGELEPADDLIGQSFLSPNARLKTEELRRLNRMLFFDIVTLRNKRWINKIVRLMEENSQKRIFFAFGSSHLLGEGSIVQLLRERGFVVVEQQLAKKSADPGERSGQTETAKSASDQLLGDSLWVIFGVLATIPCFIALFLIIRCLRIEAEPKDEMKLNGNGKRRPSIKLVAQQLSNATNGHFANNVTVYGGNDTVSEDKNGHFANNVTVSGGKSGGNDTLSNGTNGHFANNVTVSDGNDTVSDGNDALSNGTNGHFANNVTVSGGYVTVPDGNDAVSEGKNDHLANNDTLSNATNDHFANDVTVSGGNDTVAKGKNDHFQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUG6</accession>
    <name>A0A914GUG6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914GUG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1131.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1131.t1"/>
        <property type="gene ID" value="Gr19_v10_g1131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="624"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="655"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="846"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="941"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1158"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="624"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1158"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1131.t1"/>
        </source>
    </evidence>
    <sequence length="1198" mass="129734" checksum="446B9CA6AB43F787" modified="2023-02-22" version="1">MNFSNMSSVTTTKSGPSLFGFSSATTTTAPASLFGMPSATTTTAPASLFGMPSATTTTAPASLFSFPSASTTKSSAPLFGMPSATTTTAPASLFGMPSAMTTTASSSLFGMPSATTTTASAPLFGMPSATTTTASAPLFGMPSATTTTASSSLFGMPSATTTTASAPLFGMPSATTTTASAPLFGMPSATTTTASAPLFGMPSATTTTASSSLFGMPSATTTTASSSLFGMPSATTTTASAPLFGMPSATTTTASAPLFGMPSATTTTASAPLFGMPSATTTTASAPLFGMPSATTTTASAPLFGMPSATTTTASAPLFGMPSATTTTASSSLFGMPSATTTTASAPLFGMPSATTTTASASLFGLPTSSAATIATTAPPIPPKMNFKDLQQTLLKLRVDFEQQEKYFMDELDDLNAFDIVLRRAQDKVFILGQNIDELEQERERFVCELDIMSQQQTELDLLVTEMEKIMGLPPLDQQQLSGQPSVVLRDTANATPADVQRQNILQLQMTVNAQMKQLDDELGDLCEQISDLQRLSGDANGLSGDELKEHEQHHSMLEQIHQILRSQLDTLVWVDKQSAVLMDRVNRATADVLTLCVVGMSEKTHTAATNVVKSGEKKPKPFADFKEFDFDDRLLKAIAEMGWDRPTPVQSSLIPLALDGKNVLARARTGSGKTAAFLLPLIQKIIQLSQNSKARQGHGPFSLIIAPTKELASQIFALLERLSDSLVFIQSLNLALFVEANDETLENETLDVLVSTPRRLLVAVKKVPKLLANVGHVVLDEADLLFSYGYRDEIKFLKGLLPPHFQTVMTSATLNEDMTELKRTFVVGKVLSLKLKESDLPGIEQLQQFQIQCLNDEERFSILLAMIKLKLLVGKSVVFVSGVNRCYKLHLFFQAFKIASCVLNAQMPANSRCRIIHEFNAGRWPYIIASECNDIFDGDEDSEQLENGGESAAQDGADDGKKQGTPSHQRIIRKRKELKKKNKRRQLDKESGIGRGIDFHSVSNVINFDFPLSTDMYVHRVGRTARGFNKGIAISFASQDEWTLFEMVRTEINERMGQPVIQPYEVQMRDFESFQLRARDVMAACTKTVIRETRMAEIRAELLKSKRLDAYFEKNPREKRALEQDRKQFKLNVHSTGIADVPDYIVPKALRGQDFNSELKRPKGERNVRKRKRPFEKAGARRKHAKMLSDPLQSFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVU7</accession>
    <name>A0A914GVU7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10876.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10876.t1"/>
        <property type="gene ID" value="Gr19_v10_g10876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037908553" evidence="2">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10876.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16050" checksum="C50835B9D7A474BB" modified="2023-02-22" version="1">MAQQILIYIILVLFFGGTWAGCFHSREDENSVEDYMTEDSVISLNPHLSGLSLEDLFGCNEDGRPSMAEQQSKRVLEFLKSQLGSATPSKNIDKMLEIPMNQQVNGYDAKFKNKIDQLTEEKGNNQKKRKSTTLGMLLKSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW31</accession>
    <name>A0A914GW31_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW31"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11729.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11729.t2"/>
        <property type="gene ID" value="Gr19_v10_g11729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11729.t2"/>
        </source>
    </evidence>
    <sequence length="445" mass="47283" checksum="53D66E9E927A2CF0" modified="2023-02-22" version="1">MSHAKVTGTEKSGLSVSVGDLLIVSNTLPSATSSALADQCPHTSRSGGGSDSICSSSSRSISNSSNSYHSAKSCGGTARCCPHCCASSVSSSPSASPSSSSAERLSPSGHPEAVVVVDSESPKSDCSSSSGSSCSSSSVIINNCTLCRQHRTPPAAVATAIEQDSRVGSEETLKRADSRLTIPRGSQSSSRSSDESQRKRPLSQRQQQQQLQQQFGEVDKLNAIVGAAAKSCSCEECVLTRQREQLQQQHDQQQQHAAGLSAGVGVSHRSSGGGGGGIAGQLSIALANAQLASGPTTSSSSGTSAQQQQQQQQMMYCNGPSTTQTIEEQIKQIDRISKGEVQIFLNVVGIEMECDNSRKSLEIINRRLDDLNDEVRRYREFLGHEKARRDPALYKTSNAEPLSSYNDSICRLIDSLTTQLTMEWTEKLRSIQNQTVAKFASGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWW6</accession>
    <name>A0A914GWW6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBL3-like ubiquitin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWW6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12097.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12097.t1"/>
        <property type="gene ID" value="Gr19_v10_g12097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12097.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14420" checksum="C6D11FBE39FAD3F0" modified="2023-02-22" version="1">MVKDETVTAATTPSAEKQPANKISLKLILVSGSTHEFNEFTPSTSAAEICQHVFENWPTEWTEEKVSNASMLKLIYHGRFLHGSVSLGALNLPAEASPVMHLVTRETLPETNSNENLKKNKSRTCVCCCIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYI6</accession>
    <name>A0A914GYI6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYI6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12327.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12327.t2"/>
        <property type="gene ID" value="Gr19_v10_g12327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000011">
        <property type="entry name" value="Putative ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="39"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12327.t2"/>
        </source>
    </evidence>
    <sequence length="343" mass="38051" checksum="7789A4305B53C60B" modified="2023-02-22" version="1">MLRHLSHYWTSIRSVLVSISSVPGKRAFNSTWQRPNAQHKSDLAQRICDRLQLEVAKAALKKFSNKETNVEIIESVRGEDVYIIQSGCGEINDHLMELLIMISACKIASACRVTAVIPCFPYARQDKKDKSRAPITVANMLSISGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIQETIPHWQEAVIVSPDAGGAKRVTSIADRLNAAFALIHKERNNPNEVEKMTLVGNVQDKVAILVDDMADTCGTIVLAAEKLFEAGAQKIYAICVHGIFSGPAIDRLNKSKFEAVVVTNTIPQEENMKRCNKIQCIDISMILAEAIRRTHNGESVSYLFSHVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ33</accession>
    <name>A0A914GZ33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12117.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12117.t1"/>
        <property type="gene ID" value="Gr19_v10_g12117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12117.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47242" checksum="20BFDAA5B1DF6451" modified="2023-02-22" version="1">MVGHPRDSVIAEMVGHPRDSVIAEMVGHPRDSVIAEMVGHPRDSVVAEMVGHPRDSVIAEMVGHPRDSVIAEMVGHPRDSVIAEMVGHPRDSVVAEMGEMNRKNRSDAFVAAHLIPLIVPDAFGMFSSSSSHPFPSSAEFTDRTFDPTRVYRNEIAGGKMSKTYESLVHNIFRPEQSRQESSAFLPPSFAPPSAQLQKLDKQQQQNAALVPSPIVRMNPGNKERPRISAAAMKRVEDQLGKDALDDTHDDELWNSPLDEIYAELGIDSSSSGSMFAPTPIHSALSSAYTSANRSSRRPAPGLVSEYSVYVPKCSAEYAQLANSSPPAQSSCRSSTMGTYRLGMPSSMRSSSSGSLFHDKPDVRRTLVDYKDFSSSSSLSPYMYRAGSGQSQLDSRIVGSNFVQVSRPKDRFLEKIEQTLAEVRNSPRYTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ77</accession>
    <name>A0A914GZ77_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ77"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12146.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12146.t1"/>
        <property type="gene ID" value="Gr19_v10_g12146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12146.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10570" checksum="A1430D01AD0198E4" modified="2023-02-22" version="1">MCGSIGRMRVGSSSKIERTNGRGGTDDQDDQRVIKGMQRDDQRLIKGMKDDQRVIKGMKDDQRVIKGMKDDQRVIKGMKDDQRVIKGMKDDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZE5</accession>
    <name>A0A914GZE5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZE5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11812.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11812.t2"/>
        <property type="gene ID" value="Gr19_v10_g11812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000003">
        <property type="entry name" value="Protein NipSnap homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="5">
        <location>
            <begin position="440"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11812.t2"/>
        </source>
    </evidence>
    <sequence length="539" mass="58896" checksum="E9F88F7973440A36" modified="2023-02-22" version="1">MHSSILKLARGVPNAALSSFSAPLRQCSSVAGLFNDQPPQHYANDGNEPEQRGQFGNVPEQRGQFGNEPEQRGQFASTPQRRFINRGVNRVELLGGVGGPPVVKQTAQGSAFASFNLYTNVDRRLNNGGTMSSTEVHNVIAFGGMARYVEKNIERGTRVYMTGRLHYTGGAMNADGSRTPRICSVNLEAIYPLSKSGAVFNAGGSSGGGNSFGGGGSSGGSSFSACLGLNLSSQLNVPFSACIIERQDEFGHQIFAGDSDIRAVAFGHQAAAGDKHKLPSDIPPPSPLSSDTLAAAQGWVSRILTGPASGDERKQSHSSMLSVGEYIYELQTHDAVGGDRDKYLDAYKKYATEVQAATPGATLFGSWNVLFGNQDQVVNLWRYQNGYADLDSHIRALQTNVSMKSAEVDYAKLCRRRRTVITKPFSYWGEPRAREPSHVYDLRSYVLKPGSMIEWGNAWAKGITHRREFNQDVAGFFSQVGQLYMVFHIWAYPSMVGRNTTRQLTWAKPGWDTTVEYTVPLIKKMQSRILVPTELSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H075</accession>
    <name>A0A914H075_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H075"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12834.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12834.t1"/>
        <property type="gene ID" value="Gr19_v10_g12834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12834.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26316" checksum="AE2CE516E4857556" modified="2023-02-22" version="1">MCGCCCCCVRLSKSDWVACPYKRICFKMSSFLIFFFVCPLFICSCCGFHLKWWHKHSTRREQMEKAVDKCCPRDYTNNAEFCCANNLFDEDAEVPLKECQEEGMPMSTIFRTVRCAQREFHGSTDICRFFCCDFLKNVQGASKETNWSINCTSAAFTVGMTAKKQMRRLKRMGSDTEAPLQFNAFKECMHMPERFVDDTDDSKADSDDEKEKNKMLLREVCRGENGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H276</accession>
    <name>A0A914H276_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H276"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13450.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13450.t1"/>
        <property type="gene ID" value="Gr19_v10_g13450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098574">
        <property type="term" value="C:cytoplasmic side of lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903744">
        <property type="term" value="P:positive regulation of anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22789">
        <property type="entry name" value="BORCS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018780">
        <property type="entry name" value="TBORCS5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31634">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31634:SF2">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10158">
        <property type="entry name" value="LOH1CR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13450.t1"/>
        </source>
    </evidence>
    <sequence length="499" mass="54797" checksum="7AEAAE399BF2FB5F" modified="2023-02-22" version="1">MGNEQSGPFAVGGGSASNKAEDDDDQTPPSTSTGIPSSFSFLAKKRNSTKSTMISSIVVVNEGASSSSLVDPSKDPDLKRIKEIPHFLPLLRGVLPGHRDLPEVHQKIDSKNILNFLQRLQHHFRLCAQTVATEQGRMFSRIVEVDQLISSLLKKTTTATKRLESLNSELKRVGSLADQLESIQVSLNDLTRAADSLNQLLSFDDRLPSLQIAFTPILTRKKLTETLSLNNGSRLSATADRRTSEREPRKAQHREIVILLQHRGPGNFAVFGTFSMDGPPPPPIAKPGRVRVYRVVKEFIPTKADELKLCEDAVVYVKEAVEGAEFCKAKCAEGGAGGFIPMESVGQHLELIEFPLHEAARTGDFGFLGECLDNKVSVNALDRSGSTALHWAAYAGHTRILKHLLSVPNVALMAQNKLGDSPLHAASVKRRLDCVHLLVEAGANVHVRNRQGKRPIDVASDPEIGALLRTTMVERGREGEEDYLEEEEEGEEERFVRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H518</accession>
    <name>A0A914H518_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914H518"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13735.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13735.t1"/>
        <property type="gene ID" value="Gr19_v10_g13735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038091740" description="Glutathione synthetase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="16">
        <location>
            <begin position="268"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13735.t1"/>
        </source>
    </evidence>
    <sequence length="540" mass="60932" checksum="6027447C0E2D19E8" modified="2023-02-22" version="1">MSTINSNFQIVFVSVVFILCTFFGHAAPPHQHNANYKTASNDGAESLQNYIGNMALTDIELKKLAQFAIVWCHNNALILRPIGKEDRVDIAEFAPISLFPSPFPRDAFDRAMKVQEAMNLLYFRVARDHDFLMNAYKDTIRSDEFIAKLVGIVKEVQEEGIRQPITLMLQRADYLLNVVEDNETKEVKYEPKQVEVNTGAIGGMGLKRRTTELHRRMIEKVGLDASTERVPENRPDAALVDALHMAWELFGDPDAILVKLEAIASPFVYDGRYNDEELAKKSGNRIKVESYSLSDKSERENSTKRLQLDMEDFSLRLDGRRVAVVYSGQSALGCNHIGEAGMEFRRIIERSTAIKVPSLAIAISSSKKVQQMLAMPGALERFFPNPEDAATVADIRATFAGLWGLEHNDEKTQRIIQDAIENPGNYVLKPNKECGGNNFYDEEIAEKLKEFTPTERAAHILMQKLQPMVVKNYLVRPFNEPKLEDVIPELGVYGFLLGNLHDGRVLHNAHQGYHFRTKLSHVNEAGISAGFGYYDTAYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6B7</accession>
    <name>A0A914H6B7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gag protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6B7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14410.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14410.t1"/>
        <property type="gene ID" value="Gr19_v10_g14410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14410.t1"/>
        </source>
    </evidence>
    <sequence length="783" mass="90207" checksum="DDB179225B8C237E" modified="2023-02-22" version="1">WIDRKVNRKNCDLPNVFESKVYARALALLGKIDEHLVKQQNSEFTTTVQYNQWKTNMLYKITTELPYLDALKHLISVEKGLLKVENLTMVSTVADLSLRLVNVVGAAVFGDLDRAESRKKRDSTFTCILKSISIAYERKREPLLKISEMIMTDATKLRLYCLISVSEVYPSTVVLSDLRVRAQHCNNIVHAEQLNQSTAIKRLNKSTNQQHKASLQQQIQAAHQGPNRQRRQSNLGQRVQAAQPVLKAAPTPNKLLNNKFKQYNEQALEHQVQAVQQATQPATQQCRGQSSKNWERHSRFETQLEKAQQEAKHLEIFMDDIREASSAWADLLRKLQAADRETGDAEFSAFNKKEKINDKTEEASTKLQDLRDLIGTLTVQARIYRSRADKEERDAQSSHAQALQQNATAPTRNNAPAFTAPLYQFQPIQVERFSGQKRQWPEFYESFKSAIGRQPISKAEKFNLLRNMLGGEARQLVSGFRLEDQNYDVVLQLLKDTYGAPEEHIRALHFELANLKACKSLRDTQEFLLQLERLTRELNNAGEDFEGPPTFLMLEKKLTPAFLRTILNKKGEDPAQWSTTKFRNVLNEAVRKETQIQEVMREYGHQQHQQSAQTNNQSTHAQPQRAHNEAATSRTPEQPDRTVVSATVDETRQWHNERPPQRPCQPIRQQTTQQEQLRASERSQHSSPSETGNNQREPPYPCIFCGSNHWHEECQQFNTLQQRLDIIRAKQLCFKCLKPNHRAYACSRPNKCYRCKRRHPTALCRDRLNESAQDTTATNERNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H774</accession>
    <name>A0A914H774_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H774"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14338.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14338.t1"/>
        <property type="gene ID" value="Gr19_v10_g14338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14338.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29700" checksum="72FDA0BD254F6A28" modified="2023-02-22" version="1">MFIVIVLFVEFIEKFIVGMDNAADVHFLLLPAHKAILEKASDVFEAMFRFDEANAKAAAAGTDPSEEIKPVEVPDVEVGAFRVMLAFIYAADDLSELLNGDNAISVLYAVPSGVLTSDQMMSVYQYHSHSDRALPELYPLQFPTNGRAVTAWRSVRTEWAIPKKDFGIFYYEVKILEKKNNVSIGLATKQMPLDKIVGWCKGTYAYASCGSFWGHAVEGCYHNGNGQTTGLFVDFGADLFPCVTLLRPGTKIEANFGPNFKFKIAAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7U2</accession>
    <name>A0A914H7U2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7U2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14528.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14528.t1"/>
        <property type="gene ID" value="Gr19_v10_g14528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037000734" evidence="2">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14528.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19250" checksum="ED830F757E8F4F3B" modified="2023-02-22" version="1">MIALLILLITLVHPSLESFWDVKADNCYYALRHRGTPSVGMFRKMQQWGTTDIWPGLELNEHDCFGNFAGCQTYSCIDAKNGDQIFVVNACAPNGGKCTNRDLDPICAKDGGIGKCEICLQGLCNKPDIELKVPVPKVTEKRDDPETGTGYAKNNKSSSKETGTDGAKNESSSISAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA06</accession>
    <name>A0A914HA06_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HA06"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15423.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15423.t2"/>
        <property type="gene ID" value="Gr19_v10_g15423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF32">
        <property type="entry name" value="DCN1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="127"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="194"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15423.t2"/>
        </source>
    </evidence>
    <sequence length="396" mass="44923" checksum="869D60BD03F509EA" modified="2023-02-22" version="1">MIIIVVFDHNEGAAALSCEDQFCNSQISIQLNQPGPSMAILHRIKERPRQSQWRPQFFAYELGGIVGEKMTRTSGMSPVARAKPRAELTAAVNNARRAAQHDENSSDTEHKGSNNEKAIIDCESEEWYAGSIDRYLAEQMVVGDGKMPRGTFLVRMRQQAADSRFALTVNNSGEGQSDIKHYKIRDNGTDFFVSSRGTFASIRNLIAYHSGEPARIGPNGMVRFLRDLGIGPTSRAVMVLAWKMRAAKPCEFTQQEFREGLTALMPIGTTLLDIDNLRTALINAEQETVAERPKFRELYQFIFKYVKSANQTSLELQTAVACWKVLLGDGDHRVSSWVEFLRARKVRGIQRDAWNMFLEFLEKIDSDLGNYDAEEAWPVLIDEFVEWCRNRTIERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA24</accession>
    <name>A0A914HA24_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HA24"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1561.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1561.t1"/>
        <property type="gene ID" value="Gr19_v10_g1561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1561.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9079" checksum="F034BDB1437DEBB5" modified="2023-02-22" version="1">MRQRRMPKETNLSVDFPSIRRIGQTSMDNDEGTLKGVPLLLIAVEGQRHNSLQKADENGQHGRLPLENGLNTREMKIIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAF6</accession>
    <name>A0A914HAF6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15269.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15269.t1"/>
        <property type="gene ID" value="Gr19_v10_g15269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052854">
        <property type="entry name" value="Serpentine_rcpt_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47518">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS EPSILON-13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47518:SF9">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15269.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37995" checksum="479969F82BD945CC" modified="2023-02-22" version="1">MSLPSGTVVLFAYTFFSIELLIDIVVLAVACLNLAVIWSTKLLHPNLKCILITQSVAVVLLVLNRSAMLLIKLISDNDVFAPTNIILDDLMSFDVFYRRMLGHALIIERFIATVRTKSYENYRKIHFNLAWFSITFIIAFVNMIAFDYSWKITQFNLLTSIFSAVLSFVEFLMIIIIGRYNRRKYNSQIEEASANNYHIGQRYQVLENVKTAKQLFPTFLCFLFSNLSLVILCIIITTNEDMDAYQIKLIYSFFFLIGTILAGAIEISVITHHPLLKRRVVRLLKKFYHLRRSNQIDVAPHSVELANNRRDGTNEMSEHFKTLQQLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB05</accession>
    <name>A0A914HB05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15700.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15700.t1"/>
        <property type="gene ID" value="Gr19_v10_g15700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15700.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8147" checksum="D7FD76319D7E1815" modified="2023-02-22" version="1">MSTNFKIGIEKREAKRQKRKEERRSSGQRMNAAISVRKLAQPSTSIAMSAEAVFDGPIIQFLFKLFSRQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC24</accession>
    <name>A0A914HC24_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC24"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15726.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15726.t1"/>
        <property type="gene ID" value="Gr19_v10_g15726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15726.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18960" checksum="00A1924FDB2C9553" modified="2023-02-22" version="1">MPPQNQKRMPPELIAELAFSLPMDVRWAIQRVSAVFDHFVQKKQLDWIKNELQRQKILHEKKRHLAASRQLILKISKQIMPNRLTNLRDNVAAHFRLSNRVGLTPEEIKGGVLTPEMFQRQLDEMLATIDHQSFESIKWTAEFLSTKTNEYVGYSEIEGASHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCK0</accession>
    <name>A0A914HCK0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCK0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1580.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1580.t2"/>
        <property type="gene ID" value="Gr19_v10_g1580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1580.t2"/>
        </source>
    </evidence>
    <sequence length="590" mass="67283" checksum="596F4B7155522E61" modified="2023-02-22" version="1">MKRWPFTIRRREESPYETKVLHSSFLKQAIVQVKVPLLFFSDNQFCEVVAYSPGFGRVGSFVRHNNLAMDSMCFAWIAFAALFKSVELRTLMFALDVKWIISGIDRLMAKSEIIDFPKKLGMSDPFNRSLGVVVEHQFCKDSRKVLVIKFSTESNGLCEYCDPTAGGQQQNFPIGSWARFLPIRNFSNEFTAVNPSATNRPNGVSLLQTEPKIKLALSHDLFYLDQDPSKNIIHAQMFGELHCTRVFMLELRQKRQKLKHFQPRLFIMFDPITNRWIPIHFDGLDSPLYSSENGQNSNDQSPNQPSQKKTENNAPGTDFGDKPKQLQTANRDNERGKRYFQSMESRSRPLTSSLGRVDFKQNNRRSYDNRNGNGSRFSSNSSVAHKPTVQTNLQGLIVSVSNNSSNMFVYTCRFPSEEFSMNRSTTSIPDGVKHGSWVKFDLTVDSRGDKTVSHCEVDDAPPGWKVTPVRNTIQIELIAFVPKKWHPDTMAPEKRIVPTNWIDEMLDFQGLLTEEMADKSVKVVVERNKHPTGKTWHLVKSNATQIEYFFNGMFVDHHPRSNYRPAPPDLSTALKPLPVELAAESSNCAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD79</accession>
    <name>A0A914HD79_GLORO</name>
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        <submittedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g15549.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15549.t1"/>
        <property type="gene ID" value="Gr19_v10_g15549"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="26"/>
    </dbReference>
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        <property type="entry name" value="Myotactin form B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF11">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ETA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="4048"/>
            <end position="4073"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="179"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
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            <end position="586"/>
        </location>
    </feature>
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        <location>
            <begin position="990"/>
            <end position="1090"/>
        </location>
    </feature>
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            <begin position="1092"/>
            <end position="1183"/>
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        </location>
    </feature>
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            <end position="1489"/>
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            <end position="1600"/>
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            <begin position="1749"/>
            <end position="1842"/>
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            <begin position="1845"/>
            <end position="1948"/>
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            <end position="2042"/>
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            <begin position="3601"/>
            <end position="3702"/>
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            <end position="3802"/>
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            <end position="1961"/>
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            <end position="325"/>
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            <begin position="1718"/>
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    </feature>
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            <begin position="1926"/>
            <end position="1936"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15549.t1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD88</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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            </authorList>
        </citation>
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    <sequence length="377" mass="42694" checksum="18E92FDFCF2D4153" modified="2023-02-22" version="1">MLPRFFVLLGFTIFVVSEKNAVNVLRDKSGTIEVEEKDEKKKGDVLNDNGIRVEKKPWYEQAWDRLKGLFDRDCSRKKRLIDGEHSINEQQLIMNAKIAFLKSGDTVVDSPKGPMRNAETDNLEETIEMANTNRNHRKKKRFNSIDQLYMAHGWMPADGGRDPSEFGRDGDAFGELIGQSESRAADNEDERTFPLEGKQMRGWSEDEAYWDRPLYGTDQLQQQNPHKVATKNLSQLSEMGIGIADEDDQSIVAFIEGGSATQAEKTAKLNSDDRSASEPSRPPRPFHSSESTRWQNATQLHPSTPPSNNVNKAHQHDALSQGELVSSRSMFNDRQQEVESEQKWDNGRILAVQNQVQPLVSKAANPEAPKWSQRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15657.t1"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDT7</accession>
    <name>A0A914HDT7_GLORO</name>
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        <submittedName>
            <fullName evidence="11">CTF/NF-I domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
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            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDT7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16212.t1">
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        <property type="gene ID" value="Gr19_v10_g16212"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="term" value="P:DNA replication"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="CTF/NFI"/>
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    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
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        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
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        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF8">
        <property type="entry name" value="NUCLEAR FACTOR I, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="64"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
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        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
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        <location>
            <begin position="567"/>
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        </location>
    </feature>
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            <begin position="926"/>
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            <begin position="983"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16212.t1"/>
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    <sequence length="1080" mass="116436" checksum="4B9540793869A554" modified="2023-02-22" version="1">MASKASHNHQQQQRNSYIAKEEGTVGSSRWHNRTPSSPSNSAHSNNNIGTSLASSIRHDQQQLSFHDEASHSEEFHPFVEDLLPHVREFAFVWFNLQAAKRRHNKRCDQSMTLDEERRTKESLMEERPDEKQKWAARLLGKLRKDIQPQYRDIFVQYITDPRQQRALCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLEKYNTCKFPSLCVNPYHISIAIRELDLWLANYIFTTDPDKPELRPKDDDVSDNEGIWGTGVFSAFELKKLHKPSILSGIGVPVRTKQFTGVTALVGDDGDLVRKTSSSGIVSGLPKPVALSVSSVSTTATIPNYVECNSCDGSSSGAGIGNNIKQEQHQLLDHNNVQRQQQQQSRHQAGFAAYGTPSAVATAAHVAFITPVEVNGAKNGADDVTRISSDFPNFDEPADKRSRHASRDSCGSINDQEIKQLTARQQQSVQSVAEQKMVPGGVGIKTTYTVRMQQQLQQQQQQQSMQVAEQQQQYADGVHQQFHHQQGSSNNLQQQKTFPSVGSAFSAPTPAAAQLVQRRHTTAAPSSSSLPSSVASAAAVVSSMANYAPDQQQQQSLHFATSIIKSSFQQLQAAYGPPTSLNATAMLCGGTTAAPSSSVGCGVVGLNRSSRRRSGGSTDASNSFAPLISSRKRVAVVAAPPQPEDQQQSLRKEERMDAVITTVAAGGGGGLLEDDDVDVDGHDNQRQQCQDEAVTDDHQQHHHHVDQHQQQQHHSVVSAACLNIHQPLSQQQHKYEQPLLVSPIKEFISRPTEAARLVTPRPIIPNFVGDLFTASAFLRNGYQSTLTSPIPFFSSPLTTPRGTPIPGGSRLSGASTSVDDYGSLMQSMLATSSNSNGVPLLHCFNENSRSPLLQHAATAGLFGNVVLHSRSNSIGGGHGSRPGTTTLSMLDSNGLSGPPISALGTSLSSSAAVHHHLNQYGGGSSIHHHLSAMAPHHGTGSSTNTMTSHNNRIKDTTSPTMVDSTTSQCGAMPPDSTVAVTSADSTRVNVAGVTSSSSAFCASSSSMAAAALSLMASAVGSGSSGDGTTKTRSSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE25</accession>
    <name>A0A914HE25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE25"/>
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        <property type="gene ID" value="Gr19_v10_g16500"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036780113" evidence="2">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
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            <end position="174"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16500.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="29965" checksum="D3AD6E6811E4B095" modified="2023-02-22" version="1">MLRSPVPLLFLILIAIAVVNPAEVLPKETISSPEVQLQQVPRSTSSVPNDTVTWTEFRWVLTVIGATIVLLFLIVLGALCVDLDRESELNRLRYASILFFGYFGIFALFGVVDRQSIWSTVGGSVILCSIGLLSMVFWRRAWLLIPEYMAIVYLNAFFGYVALLCVGIASYLGAACLNGYDWFIFGGAFLCFVELLAILVLQPRSRSLDIVALLYGHVLIVYIGIVGNLSLVRVGGNLSLMVPFGGMLPVFCAVIFVLFCLLILFYRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE41</accession>
    <name>A0A914HE41_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE41"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16176.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16176.t1"/>
        <property type="gene ID" value="Gr19_v10_g16176"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16176.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19692" checksum="5F184C80899845EB" modified="2023-02-22" version="1">MEQYNKPLDTIMDENETQKRLFVLGLIILFCWVIVIILCAYPQLFRDLLLQYVCCCFAGFAVRRRTKCQQRADKLAKARKRVRSASKSFITVSTAVTPSAIMLQEIALSELRPNKSTMGRHRISMSEPICELDPAATHHHSLLESGEGHSRSVVEEAQQRQPAKATVVPFDGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG16</accession>
    <name>A0A914HG16_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16621.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16621.t1"/>
        <property type="gene ID" value="Gr19_v10_g16621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16621.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15101" checksum="C5A27839E622B718" modified="2023-02-22" version="1">MAQLSLQRKYGLIFLLGWLANLFLCCLTRTIGGALLLFLLLNSYTAVIFTIVFTVCQFLCVLITSLTLIADDDSNPEIGFKRDPILWIKSRHWVPILFSAIFLPLFAAQIFLINRYAGHLGLGSKRSGYSAPTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG26</accession>
    <name>A0A914HG26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin/FtsZ GTPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HG26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16628.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16628.t1"/>
        <property type="gene ID" value="Gr19_v10_g16628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004057">
        <property type="entry name" value="Epsilon_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01519">
        <property type="entry name" value="EPSLNTUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="48"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16628.t1"/>
        </source>
    </evidence>
    <sequence length="517" mass="57929" checksum="20B112445890BBA8" modified="2023-02-22" version="1">MPSNIITVQVGQCGNQLGMAYWERMCLEHGIASDGQLLREDQRGADCKDIFFNENCGQKWVPRALLVDLEPRVLSDICNHENNAYSELFDMDNIYQGPTGGGAGNNWARGYNPGGRVMEDIMELLEAETERADHLEGFAMCHSILGGTGSGLGSRILMELKDRYPKKLIQTYSTVQPMTCNVQVAPYNIVLSLESIMEHADTCLLFDNDAFERHCKEANPLQKLRRDGTNSDDLANPSEKKNYAKVNSMMSQVMTSLSAPIRFYSPVYSRLMQISASLNPFPPMIFLQPAITPFVPTREEGPKQQLIRFPRPKDVISNLADPRHLISSSQAILKRSGEAERLNNYLLSGLIIVQSMAQNEAMSFSGSVAAAGIGISDLYSHMRSRNQSRTNDNVYKSPPWMPSTMHLTSCRLSPYLNHDQHPVTGLLLANHTQISVMLKSMANDFEKMWKRKANVHQYESAFDKGDNNPDAGKDECEKKMSASKESLDKLLALYREACSDNFLGTLPEEHFPKEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGP8</accession>
    <name>A0A914HGP8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CHCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16802.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16802.t1"/>
        <property type="gene ID" value="Gr19_v10_g16802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16802.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19314" checksum="2D223AE1F1872D74" modified="2023-02-22" version="1">MDAQIHQQPAQRHEGDSSMSRFTFSIPFNSTAWTRSADTTRKAPATTHSIIQMSKEEFFTPIKDDHIRRLSQTPIEQLFNTGYNPGPEKPDGSVNFECHCVSHMVASPCGHQFRKAVTCQKAVKEADMDKGECAEEFYSFLKCAMRTQCFRMPGDPGDNDGDPFEPNMDGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGX3</accession>
    <name>A0A914HGX3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGX3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1707.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1707.t1"/>
        <property type="gene ID" value="Gr19_v10_g1707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052664">
        <property type="entry name" value="BTB-MATH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743:SF171">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743">
        <property type="entry name" value="MEPRIN/TRAF-LIKE MATH FAMILY-C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="228"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1707.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="50833" checksum="5D6F643DEB525021" modified="2023-02-22" version="1">MPPVTEKGIPIESENKKANATKAKKKKLPKKLKECFECVDAGSIVLIASYLDIPPEPIAEESSKKAKKKRRAPFETPAHEFGCIQWRLSLVHQLRKDGKGGFSKHILKLALHSDHRKDIAWRAELSGTLTMKKWTDKVPEGTNPRKLNELAEHFATSFNQFSQMHSFRTEFPLPIAGNAFASADGGSCDLANVYLKNRQFKFELQFLLLDVEMGHTPLLDFQKNQSLRNAVINVGTRKFYVNKEYLSMYSPIFATMFTSEGFVEAREHQATLEGVTPLAFNECLHLLYDPLRLPEERYIDELLELARCYTIQVLTERCEKKMLFMRNDDTTVTIEKRMQRAEDYGLLWLKASLIMKNDADVLLKIERISDMTREVLERKKIATVEDEEEKKKAKEEAKKEKKMDVDGQQQQNKPGSSSAAVHGRGGGGGGNRGRGGRLRRGTRGVSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHQ0</accession>
    <name>A0A914HHQ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHQ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17611.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17611.t1"/>
        <property type="gene ID" value="Gr19_v10_g17611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14692">
        <property type="entry name" value="bZIP_ATF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="433"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17611.t1"/>
        </source>
    </evidence>
    <sequence length="493" mass="52034" checksum="3B58A3DE4DA9DCD6" modified="2023-02-22" version="1">MSRTEMICEDVNRNGVAMLNALDNDDHLLLLNCSDMCLDYGGGTALMSRAQMVCEDVNYDRMANAGGGGEAAAVHNPPPGEAYALMEFGGSLFCVPASAFAAAVRVPPQSQVWPSPPADFAVGVPLSQLQQDEVSVGPRLPSVRHGVGGLRHSVPQSPARPFVAECAASRGALCGQQQLSAAVIVSDAVSSITALPLIRPPPESIVLASSCAFSELTTTQRASGKNAAEFVCCAAQGVPRLYCSSSSSSSSLSTDGPPSSSSSPPSASSHPPSPSPPPPTSYSSSRSFCSSSSPSSSASSFLSSSAPSPLRSTCVKPSSPPLPWQLWIDEMIREVQAEVRAEQMFRAGCLSNDCSNFSSSRKRSFCSASPCSTTSSSTSGLISLDDSSSCSTSNSSGSPRPFPSSCSSQTSQPHAKRAKKNSLLTLSHEALAERKKEQNRAAAQRYRSRKLHLLEHEREEVWQLETGNAQMRAEMAQVAEQIAKLRAQLLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI23</accession>
    <name>A0A914HI23_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI23"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1683.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1683.t1"/>
        <property type="gene ID" value="Gr19_v10_g1683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1683.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33471" checksum="D0D5D82DEB0F2CD1" modified="2023-02-22" version="1">MGAIMGKRTCYYEEALRAVKQAIAPVEPVAVMSDFEKAELKSFELVFPLLFSDVLSLAYIPPEEVRRAFALLVERAPIGCQPFLGYVARIFIGLTAHELDEGVDIAFAPRIDDSRDSSILSDHDYIQRVQHQQANVVPRWEHPIIRAPQFKIGFWNVNHRALASIEKTNNAMEASHQQMARELNHHPALSDLLFALKSDIDKQCDIARAARSFNHVRRKQYVIRENRLMTTLARAEYVTNEDLLNVLTLIGLQIQGYVAGIRVRNLENAREEESTAEALELSEENTGNDSQIYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI60</accession>
    <name>A0A914HI60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HI60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17380.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17380.t1"/>
        <property type="gene ID" value="Gr19_v10_g17380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF6">
        <property type="entry name" value="TMEM (HUMAN TRANSMEMBRANE PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17380.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19089" checksum="4DF528D665029095" modified="2023-02-22" version="1">MQPSNNDPFQEIPLSVAAPSVGLPLQVLLHLHAHLTPFAIIAQIGCFLLKFHILYPTYRVTLIALHFVSVLVHIARPVLGYHGNLKGRIPSLSAFWILSALLHLPTLLFLGLNPDIHPLPLEQFFYFLDSAFSSVELIIATILIRLLANRQMELFRKMMMTEAKEKDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIK9</accession>
    <name>A0A914HIK9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIK9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17503.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17503.t1"/>
        <property type="gene ID" value="Gr19_v10_g17503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17503.t1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45085" checksum="A0ACF44D54DA567D" modified="2023-02-22" version="1">MEDYEQLDYDEEELKSALKKAQQLKKLGNEKPIAFLSDATKEARNSSSIIASSVSSKCYINPNFTKRDNIQKAPSSGAFPIVPSNNYQYPLRSSYQRAKTHVFSLPQQSQNVPLMQPTSNFVSQMPWTTSHCSGGAQVMSTARQLQQQTTSQSGLNWDLMVDEFVKKTISVRTRRYAKSRSRSSSTGTSLSRHRRSRSVTRSSNSRPSSNASTPSPKKSRKQSNSPGRKDLKAKASQTKAQTKLSKQTIECAKAIGLGNEYLKQIEEQQKLRDEIARRKSQHRKEIYARDRDELKNETSSTGAEGVQSKRAEPYLAVVVTNLSGVEDFRKIALIAGKIGPVKKVWQESESNVYLIFEKHEDAKKFMQQYIGNSTVFGRVIDVSMKKVFLNTATFVQNSTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJZ8</accession>
    <name>A0A914HJZ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17579.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17579.t1"/>
        <property type="gene ID" value="Gr19_v10_g17579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17579.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39291" checksum="CC9188D54BEB1646" modified="2023-02-22" version="1">MVRVNPRAPNTCAFYLRLDMWKQTPPTACAYNSKSPNVLLNGPRQPARAQHVRVLSAAICGNRRPNSMRLSCNSKSPTQTCVLNGPRQPARAQHVRVICGWDIGNRSPPTACAYRASKSPNVPCVLNGPRQPARAQHVRVLSAAGYVETEVLNSMRLSCNSKSPNVCAEWSASTRARPTRARFICGMWKQTPQQHAYRAILRAQTCVLNGPRQPARPTRARFICGWICGNRRPSSMRLSCNSKSPNVRAEWSANPRAARPTPCAYRAILRTQTCVLNGPRQPARTQHVRVLSAAGYVETEVLNSMRLSCNSKNPNMRAEWSASTRARPTRARFICGWICGNRSPQQHALIVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK34</accession>
    <name>A0A914HK34_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK34"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17348.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17348.t1"/>
        <property type="gene ID" value="Gr19_v10_g17348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF377">
        <property type="entry name" value="COLLAGEN TYPE IX ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17348.t1"/>
        </source>
    </evidence>
    <sequence length="1063" mass="114148" checksum="85FF15DCE8079FA5" modified="2023-02-22" version="1">MAERAQLPAPRARPAIELNLNLDEAIVETVDLIRTVRIQLESISNILGQSLNRTVADVGDDIGRIITNVEAISRNVAESTGQLYQPLLLFLLFLLTMGNASVVPERAQRRRPTTTTTTTTEFIGGRGRRRGRRGRDEKEGEEGGEGQEVLHSLCPISVYSQHSAEEQLTDGHWLRGKLPKDFCSNRMRELCPLEREKQVEERRQRLLAQCESLRKITILGIAASVLAAMLCVLSVPFVYNYIQHAQSVVQNEADYCKHRSSSLWRELSRTSQHSNSIMATIKHRTGREASYDTPPATVTSTADQQSPTSAGQKCGCAYGAPGSPGEDGKDGKDGTDGIPGDNGPPGEDSKGEAKPREVCFECPLGPIGPRGAPGPKGKPGEPGAPGLDADGGVRGAPGSPGPQGPPGRPGLPGPKGVPGSNGTSTDQPGPPGLPGQPGPNGLPGQKGAPGLAGKNGLPGPKGPPGEPGLVGPPGKVGEIGKQGLFVAALACHQFVGLAFELGKSIELPPPPQLSKLLQLHQLQTPPTPNSSNSTNSKLLQLQTPPTPNSSNSTNSSNSNPSTPNSPMIPSLLSLPLLLLLFVSSAFAPGPSRENKLFMECAVRAPKGRQEPETVVSHAKLDTKRIILFGLGGNLYVGNSELRGLCKEDKEFGGTSNMAPEIKKASVEECANGKLTLNGKHLAFTSKKYNDYEQCFAGQYELFECPKEVCAEKSSLVLVKKDSEHKAKAYAFVYGGKMLVKAVRVAEVSADLLDCVRRECPEESVPLVEEAVRWEKRKDGKKKTEAAKAKFKVYKECAVKRNRVGTGGNNGTARMETLMAHVKMDKHVLFFGMGGNLYAGDSILAGECEEDKLFTKSKVTAMSSTLLGCHKTSPEGGGKRAKLLLRKSWRRKSAEPEGKMRSGNEQIQMEIGTNIASKGSQCHAQQTNGRRQRFDLYKCPKEVCGGSKDRLLLIGKRSNAKANNKLVSGGVLLAEEVLFADVTPKQWQCVQHICGSRARIPTAEAVKRKLDKSAKRHGTQRRLKQRRRGTKRRGRKPGGNGGGAGAEEKAKTAQNDGSHGKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKD1</accession>
    <name>A0A914HKD1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HKD1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17422.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17422.t1"/>
        <property type="gene ID" value="Gr19_v10_g17422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000042">
        <property type="entry name" value="hepatocyte nuclear factor 3-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF380">
        <property type="entry name" value="PROTEIN FORK HEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="216"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="216"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17422.t1"/>
        </source>
    </evidence>
    <sequence length="601" mass="65415" checksum="3195AE4363EAF5CA" modified="2023-02-22" version="1">MSCWTNSATAAAVAAEEVTKRALQHPMSAEQYQQQLQLSSATNPWCMLPSSSSSSVLPSSSSSSASLALSSYLYPGALPSLQQSPYPSAYGIGTCAGPVSLYQQQQSPSSPSSYHLGQSYPSAFSASTTVSPRKVEGDGNNGNNCNMDTETTQQQRRGERLLQQQQENEQQHQQQQQQNGTGRMGARCRTPQDGAMNLTESEMNKIRKNGNFGPNKPPYSYISLISMAIQQSERKMCTLSEIYNFIMEYFDYYKNHQQRCSWQNSIRHSLSFNDCFVKVPRTPDRPGKGSFWTLHELCGDMFENGCFLRRQKRFKLAHKEKEPSRRKAKGKEKRMSEQKQYQHHLMKMEPKLDLVKLEGDGVLLAGLDGTMPMSVTTDGDICGDGGHTSSSPTLGEEKKRAKGSGKPKAAHLTSLGDAVADALQQQHFGMTHARSQPPQQPNSPSLHPPPPNMFSVACQQPPLELAQLGTVPGGSVCASTQHQQLLQQAISPSQQMASVISAVGQVPLNSYCQQFQSPANPAPFSSFYPDTGVGGNQHFLHINLNISQQLFDCYSATGFPVPGAMQQPGAGLDYAMYGGGTGGAPNALYGSVMNSNSAANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKP0</accession>
    <name>A0A914HKP0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKP0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2209.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2209.t1"/>
        <property type="gene ID" value="Gr19_v10_g2209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2209.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29879" checksum="47A1B44DA39E4AA4" modified="2023-02-22" version="1">MRKTISMPTISKAPIDRVFQVELGPEAKLAQMLTGRRGCCNVCRCATQYCDVISRVQTKLGTRFCQRPNYTQPISVELNHFYGHEIFGLTVNLFRLKTYAINDKEKRELGNCPSCFNSFMEKQKISKFHEKHFIHSSCIQNWILSHGEFCPKCIVEVVATKVIKLEPCFTETSKEIKQLAYELKLNKKEIFTKFSTKNIENAKQDVNQILGDPLNDIEKAQKLMELLVDVTEKPEFLAQKTLEELRIVREKSESEKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLJ9</accession>
    <name>A0A914HLJ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLJ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g190.t1">
        <property type="protein sequence ID" value="Gr19_v10_g190.t1"/>
        <property type="gene ID" value="Gr19_v10_g190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g190.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8147" checksum="F6C26D21CDA0CBFD" modified="2023-02-22" version="1">MGRSGRINGLEILHNPTSQAVIQSVVVGQSVRPSGGHGGGDGLWPPPPPVFVSCISGWQEQQFHRSLCISRFLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLL9</accession>
    <name>A0A914HLL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase metallopeptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2266.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2266.t1"/>
        <property type="gene ID" value="Gr19_v10_g2266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF310">
        <property type="entry name" value="MMP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2266.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28736" checksum="06C7D169635C596A" modified="2023-02-22" version="1">MKIQQKFFLHIVLTLNNFIVLFDALPLNRNRRFAIPVHKWTKTTLNWRLDNENLNSRDQFIIRNTLHRAFNLWEEASKLIIFSELIKRENGADLNIRFLRGNHGDDMPFDGPEGVIGHAFYPPIGELHLDADEKWILKGLNGTDLFQTLAHEIGHLLGLEHSSDTRAVMFPRKKEHQPDFELADDDDLLLRPFFQGSFVHGTLCPWDLLSVGPLSMDLFSMEPLSVAVDLLTVGIKILVIFSPMEDILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN62</accession>
    <name>A0A914HN62_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pellino family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HN62"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2146.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2146.t1"/>
        <property type="gene ID" value="Gr19_v10_g2146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048335">
        <property type="entry name" value="Pellino_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF2">
        <property type="entry name" value="PROTEIN PELLINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20723">
        <property type="entry name" value="Pellino_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="4">
        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino FHA" evidence="4">
        <location>
            <begin position="265"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino RING" evidence="5">
        <location>
            <begin position="338"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2146.t1"/>
        </source>
    </evidence>
    <sequence length="483" mass="54594" checksum="24C61A43F6481EEA" modified="2023-02-22" version="1">MKFYNFTIGFLTFFILAVLYNAQPSFGLHYGQLILIGKQKFKMDFNKRAVANGIKQNPKYTKIMNKLPHSPFKPPIGDHEETYSITFSFDNNEAKKVVAEYGLDPDRDMFQIGREIENIDFTIDQKRVSRYACRIVAEREAPENVYIYAAGFDNSKNIFLGVNAMKIKKPDGQFDGLVTNGVLILSPFNEPPSQEAPPIHENAASSSHALESLSSRIMSPIKRIMKPLKKISRESSPRAGRKNKSSQESTPITGKEKEVSQEIFHSTCWKEVSVTGDIYSQRKERVPGQMGKFEPSLTNKLEDGTLINLCGATLLWRSAKGLQNIDTEETLKKRLQELNKKRAQCPVYMHTLVFGRTGESSTSNSNNGHSVLRKPHVYEKCGHVQSNHKWGIDNGKYKCPYCKQSSDRVIKMSLGLEPAFHLDSNAFDYAFNSCGHIASERTVEYWSSIPIPQENGNFHAVCPFCNTLLNDDKPTIKLILCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNP4</accession>
    <name>A0A914HNP4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Casein kinase II subunit beta</fullName>
            <shortName evidence="5">CK II beta</shortName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HNP4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2822.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2822.t1"/>
        <property type="gene ID" value="Gr19_v10_g2822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2822.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27719" checksum="ED85EC50195A5628" modified="2023-02-22" version="1">MSSSEEVSWISWFCGLRGNDFFCEVDEEYIQDRFNLTGLSEQVPHFRQALDMILDLEPDDDYEEGQSDLVEQAAEMLYGLIHARYVLTNRGIQQMMEKWKNEEFGTCPRVHCENQPVLPIGLSDVVGECMVRVYCPRCCDVYVPRSSKHQHTDGAYFGTGFPHMFFFVHPGLRPKRPNKQYVPRLYGFKISPMAYQLQYYQSQSPVGVVQSTAQQQQANQSVGQNQLLNNGGRQSMDAFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNY7</accession>
    <name>A0A914HNY7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNY7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2347.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2347.t1"/>
        <property type="gene ID" value="Gr19_v10_g2347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2347.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30360" checksum="0AA2E6E1C6909442" modified="2023-02-22" version="1">MENPSSSMGSNAVNNGTLSVIRHTRSAAALQDQPETSFVLLYMLTSLTEASFLAMNLTSLDPALSVAPEKRSREESENWSDVQKHVTDMFWKSCVIAGGKFCVTSVNIARNRHCLRRFRRNATTWATASVQTSRSDPAATGNPTARGRRHRRSLRSQHRPLPSGAGGCCIASGRTTSGDAGSEAGSKMAAPVIRLPTPNERRAEDDDAAWELADLEEEDWELDEAACGQPGTSQMPPIPEVLALREDERYVVIDEDEWESCAKSPSPPAWTSGAGGNVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNY8</accession>
    <name>A0A914HNY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3055.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3055.t1"/>
        <property type="gene ID" value="Gr19_v10_g3055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3055.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10568" checksum="30B0A2969356F674" modified="2023-02-22" version="1">MPLNNPVGLDEGTFAYGDWGIFWGHEVEGCSHTDKGRPGIKGKPSFGVGDVVGCGVNLETRQIIYALNEKRLDTANLFVDSAADLFPCISLRKPGTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP16</accession>
    <name>A0A914HP16_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2370.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2370.t1"/>
        <property type="gene ID" value="Gr19_v10_g2370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2370.t1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44554" checksum="DE65ED6966903868" modified="2023-02-22" version="1">MKKIAQSPLPKFDDQFHKVVNAPRKVLYTMVARRMAPQQQQQPNSGQKPDDQQQQSSTLADKARKKKDQQRQNLGITSTKAKAFTVQQQQKQAVDGGGVQQQQQQQLDETVMDQVHHQQQKQAVDGGGVQQQQQQLNVDDEINVTTSTTGSLVEYSMTPSPVQNRPKRRTACAAMLQIQQQQVKPKRQRAVQQQQQSASLSVAAPPTPPTANVADIEEAMGEQLVASLALDPAEDETGQVATMTAEERKKFNNRRKRQKKLANREHDTSFKVRIVTPVPQVVQQQQQKRRKEVDEEEEEFEIKALLALFVHSDGERAYYVDWKTRSARDIMFSKDATQRQRTKAIGQLDQFVVDCMSEEAIALYKEKERKKEEKKKQQQQQQMNGVEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPD5</accession>
    <name>A0A914HPD5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HPD5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2472.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2472.t2"/>
        <property type="gene ID" value="Gr19_v10_g2472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000094">
        <property type="entry name" value="Laminin subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000166">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF435">
        <property type="entry name" value="LAMININ SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037619319" evidence="9">
        <location>
            <begin position="25"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="11">
        <location>
            <begin position="55"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="10">
        <location>
            <begin position="397"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2472.t2"/>
        </source>
    </evidence>
    <sequence length="498" mass="55571" checksum="455D55FFB192619A" modified="2023-02-22" version="1">MPSIVVRQLVTLFLLSFWPFICLGTWLETPTEFARRDASSGHFPTHSECYNSQGTAEQCVPEFENAAFRKPVEVSPTEFTCGVRRPSRFRHQTRAGGADLHCDARIADQSHPPALLTDFNDETNATWWQSITMEEGGVQYPTTVNLTLRLGKAYEITYVRLKFANPRPESFVLYKKTKAGDAWSPWQYYSGSCRATFDLPERAPILRANETIAQCTGEFADILPLRGGNIVFSTLEGRPSAGNLEESDVLQDWVTATEIMVSLVRLNTNGDEIDFAVGGRCKCNGHANRCVKSSTEPGEAQLACDCQHNTAGVDCQQCAPFFMDRPWRRATETEANECLPCNCNGLSNRCFFDAKLFEKTAHGGHCIDCAGNTQGPHCEHCLPDHWRRHGEQHCRPCQCNQIGAVDGQCDEGGQCRCKAGVEGQFCDRCADGYHDIGPMGCSSNDSSTNGSKEVELKTKRLQMAEFDIQYKRRSVELVELQIVELQRKLGRYEVEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR25</accession>
    <name>A0A914HR25_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HR25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3675.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3675.t1"/>
        <property type="gene ID" value="Gr19_v10_g3675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00698">
        <property type="entry name" value="TMPROTEINSRG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3675.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37865" checksum="A45200B34AA24753" modified="2023-02-22" version="1">MALYIAEIVTIVRHKKFHSSFYALFVLRAIPDWLGVLNSFYGQRLPFLFGVLYPIYSKFPNWMFTIYFFIAEHTFLANNLVTIFILLNRLTAIIMPIKQEKIWQKFLPIITIFVYFVPTFTCWPAFKMDAILLLNDPNSTTDHSFLVFEAGDAPINNYLDYICAVFSVIFMVLCILLNICTFVAYKLHMKKVSINGNNNFDDVEKKLLFYALATFLGHLLVTSIFLINIITQLDDWKTKFMIFVYYPMMLDTGTVVLSSWLLLWASGTFRQQLIKDFSIIRKTNIQIIRVGPMEGPRNNNHRAVGVSIGHFQTRFSSYVQQLPTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRM7</accession>
    <name>A0A914HRM7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRM7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4023.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4023.t1"/>
        <property type="gene ID" value="Gr19_v10_g4023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4023.t1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34133" checksum="E39AF1FF563D6EB6" modified="2023-02-22" version="1">MDQWKAAFKQIYGKTPTKKESSLAPLSVRELPKSLEKFKGGAQKRKQLTVRIDGEFGSPLKLRKSTKEHLLLVNNGSETVQNAVVEEANCQNAKQMPVMGRRPIVCANVGQLLTPEKSSSSAVLVEDEEGRELGEEEEVTNVEGEQEGGGNLLQKTEEKKKEARRKKRVQNSDPNAAGNFVSVNLRRRRFAPISKFRGKKWSKIWKKRSKNRLKISALQMTQFTWRMFVWEWSSGARTSTKGRRSIIAVTLFEFFVDSFWCLFAEYMHLFIFTMLAYLIFSAVREQIFEGIGIPKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSX6</accession>
    <name>A0A914HSX6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4351.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4351.t1"/>
        <property type="gene ID" value="Gr19_v10_g4351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="4">
        <location>
            <begin position="119"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="4">
        <location>
            <begin position="288"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="810"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="971"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1468"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4351.t1"/>
        </source>
    </evidence>
    <sequence length="1573" mass="175487" checksum="A06845A9BACE23B0" modified="2023-02-22" version="1">MDPAVSSSNCPGVDFVESAETAADITHPTAAAQPFLAVQRPNSAHKKRRRSQIVLNSLEGSLPVQLPTRARLFPNVPRPPAPVQAKHSNILPPPAVAGGQKAVPCRSLLAAADKNFRAKTIFFYRDGDEYFTGVRVPVSKARFRTMDALLDQLNESIHLPFGVRRLHTPFGMSPVSSLDDLKPYGKYVVASGARNVRGVDLEAMERRKRRREEAQRRWNFQQSSLGASHSSIQLQQIDQPPETAGNTADQKTKNQHRPRAPTLNNERSSNATKPQLQKMAPFVPITFRQVFFVLNGHPHRVYRALINPNRKGQLDQLLEEVSHGLQAAIFRMYSFDGDRILDIEQLLQLKDMRAVAVPRHEQLLLNGLSSYDNIVRPVRPVELGTDAFATLPPIPRAPKKTSRSSKSSSGASSSNIKDPTEFDQMKKRKKFQNEAEDGVPANCSGIAAVAATAGVIVRRRVRKAAEEVVSVQIEAKDHRSTTGSSSHGQTQANATANSRADSDSGRPRTELDNELNAQKDEDRIKVEEAEEDEDEDEEEDDYPEEPEQLRSLRETEQERSRKRQRNKRKKVMKIDEEEAEAEEDDDAVFDHDGTGMETDHKSEKEDEEQSLEGMGQAVEDVQPVELTHRLEEADIDQKNETVDDQNGGVTVRINRTSSIQQKLGVYTDELERILYGEAAVKIQSAWRGYSTRKELQNNGLFRQKPRMMVNGGTVLHRHESKKDMYKTNDRHLAVIGPNPKSPIVPGTRTSRSSLQPYDNSTEELDSSSEREEVIHGTEFLTERKNETLNWDTNEPDPARVEQRKDPRGDAPYTVTVITGNRWAADTEANLYINMHGSNMDSEKLWLKQEFTDWLHSSAKGQRFRQNQSDSFAFRLPSRLGIINRITVGHERRGYGAGVFIDRILVTEDEVGGDGDEPMDDEHNANDCRQFLFLCNRWFDSGQVDGRLERSVRLSAFYMISSIPVDGRVTRGRWEFVLHGGTNDGRGGTTAQLAITGFGTDGQATTGGLYDTRMATAPSEALMQLDFGDIGELLKIRLEIDGAGSSPDYFLNFVEFKDLDTDERFVVMCGKWLRWRSAKKGDQPFRELLAFHIGVEPLPLITYDGKIRAFRSALSCFSAEQLCVELYGDLGDTGHVLVRVDAIGGEASVPKDAEKAEENDNNGRAAERTVAVDVPFKLEAVSVGRVSGVRVHFEPNAMGEQIFEGLITLQNIFQKQNVWPLSANSSFVLSQIRLHESTHTPYRYVLNRSHLRERVADQQQQTTTSLAKELLTTEMEGISTRLSKRKSQAKSVPSRWLLQMSVAEGSTILPEVMLCGEKQSITMTPVDNSLTDGILSFQLDNSTDFDDPFIKIRILSDGKTFLLAGTDQKQPENAEAEAGGSGELPFTYVDKVRMCDTANGDELRFPAADCMLLRHSVFELPVMWPDRPPIPILIYSVRVATGGSVGAEPSNPELIVLLNLFGELGDVGRRTLNPGDQQQQQQQSTAAGAGVSLFTPKTSSSFEFEATSIGDIRSAQLEVLTVPENTPFLWECAEIVVTDFRGRSAPFYAFKFASPFTDQCSVQRADVLPFTDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUM8</accession>
    <name>A0A914HUM8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HUM8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4335.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4335.t1"/>
        <property type="gene ID" value="Gr19_v10_g4335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015291">
        <property type="term" value="F:secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000059">
        <property type="entry name" value="Solute carrier family 17 member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF279">
        <property type="entry name" value="VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="100"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4335.t1"/>
        </source>
    </evidence>
    <sequence length="534" mass="58771" checksum="CD2DE6A05E190E8D" modified="2023-02-22" version="1">MLISAVYVPLTHKSVPFHATASLPPPPIFCSSQRLTALKKCSSNSSQFCWDSVEKGSLIKSFIMSIFLRPDQLQKIPLFRRLDSSFSSRRIWSRSETKIWTANFFLGTCVLYASRVALPICAVAMAQEYGWNKTDSGTILSCFFWGYAFTQLIAGSVADLVGGENILPISTLIWSLLTLLTPQLFDIAYWTNSPLLTLLFVRIFTGVGQGFHLPSMASMISRHLTSSEKGRVFGICLAGSHLGSVVAGGVGSLLLEWFGWRSLFHFVGFLSISWCLLFNYLSKDFLPTRRSNVVFDSTSKLIEKEEVCQNSEKTNSKTPSSTDAMSSKNESAAVPWAKLLRHPSFWAASTAQYCGANAYFTMFSWLPSYFSDNFPQAKAYIYNVVPSMAIVIISLLSPMFASRMLAKGKSITLTRRFMECCSLMGMALCFSLVSFLPDSFPSSLALFTVAMAIRGLHHGGVAVNPTDFAPNHTGSVFGVFNAFSAITGFIGVYVAGWILQMTNNNWAVVFSFTAVQCVIGALVYGTMGTGQRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWK3</accession>
    <name>A0A914HWK3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the retinoblastoma protein (RB) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWK3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5144.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5144.t1"/>
        <property type="gene ID" value="Gr19_v10_g5144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002720">
        <property type="entry name" value="RB_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002719">
        <property type="entry name" value="RB_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024599">
        <property type="entry name" value="RB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF17">
        <property type="entry name" value="RE32990P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11934">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01858">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01857">
        <property type="entry name" value="RB_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01367">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01368">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein N-terminal" evidence="9">
        <location>
            <begin position="57"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Retinoblastoma-associated protein A-box" evidence="10">
        <location>
            <begin position="348"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="586"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5144.t1"/>
        </source>
    </evidence>
    <sequence length="794" mass="90638" checksum="BA87D6F28B62ADA7" modified="2023-02-22" version="1">MQLFLTIARRQCWSLLDSTISGELIEKAWKQYDTIGQQIVLEGNRNSWMACAFFTNVWQATPIGKELVCKYSLSKLLSICEISVLEFFDKLDSWAELIVASRRLLDFYLFFDVYPLLPKLTSCSLFEFVWTLFVALRKQFTSSQEDLLHSFHLLLCLFDYVFNALQRSGQQRLLSSSFVQSLRVKGQSPLELLCEEFEGVVLDAKHLQIHWVSPLLHKLSSECEIVGYGTDNGGLLVNVEENRKAFNQLYQAALMGRSEVDERIFLAPILQNFSSTYYGEFDEVAAVSVLRMVGDLDQQQTMDVELMIKINAQDCFDKLSSRKTSSRAPLSGKSYVITTETICPNALSSNEQNEAQKLHNLLSGFKGIEDELLVYLFGDCQEDPREFVLEQVEIWSRNFASRAAEDVILNSDFDSEFQSNITQRIADIEQLFYYLLLRVVTHDRERAVNLGMEMQLDLGVIFQNVEFLAERHFPWTFELFRGVVAPIAFYKIFELVIGAGVGLSRGAVNHLNRVEESVLDEFAWKADSQLWSILSVSRSVEAFGEPSTVPGSQILSPSSTAYIQRSIDLPPAIVIFFKKVFHLSAIRLSDLCERLRIVDDLTRHKIWTLFEHVFRTKTHLLMDRHLDQLLMCVLYIIAKVCMLDITFQNIMCHYRRQPQASSRIYRAVLIEDGNTSKALSSESEKKNYDDLISFYNRVFVNCVKELVKMLHPAGSDGKENVVPLIPFPKIPLNPLTPVKIVADRINVMSMSQYAQNFAPSQPGRFVRGRYNFHQSPSKDLKNINALIGGGASSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX90</accession>
    <name>A0A914HX90_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX90"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4623.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4623.t1"/>
        <property type="gene ID" value="Gr19_v10_g4623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4623.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15166" checksum="A68F40C0CAE34338" modified="2023-02-22" version="1">MTDDWCFLPALRIWNLRNGTAPSGRNDLGVPTKRISCPGVILEDGFATWDALGGFSALFTKAVYLIRLIDQCGCVTGEGMGKVQEKGCLRSSMVRAAHGKGRCGFESHRGLIFCTSAAHRITTFITWRSWVDGRIGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY26</accession>
    <name>A0A914HY26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5711.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5711.t1"/>
        <property type="gene ID" value="Gr19_v10_g5711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5711.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11598" checksum="344CBDE8B56211F1" modified="2023-02-22" version="1">MDHARCPYVEPKAPLPSYIKAALPNDQKMERIDSIICDLPDTVIDQIPDPPRLAQLPAEVKQRVKQIERQHGKSFGTKFHEIMKYVDTLPDETKSAAKGIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYI3</accession>
    <name>A0A914HYI3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Na(+)/K(+)-exchanging ATPase</fullName>
            <ecNumber evidence="13">7.2.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.13" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914HYI3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4967.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4967.t1"/>
        <property type="gene ID" value="Gr19_v10_g4967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4967.t1"/>
        </source>
    </evidence>
    <sequence length="703" mass="76763" checksum="D6EFA21A6F8B4CB3" modified="2023-02-22" version="1">MPKIKPSESGAAGPSGLMPPESDRSQRIPSSADLIKLHHEMDINDHKLNLKELAQKYETDLENGLSSEKAEELLKKHGPNALEPPQTVPEWLKMVKTQISGFALLLWAGAVLSFFAFFFGYFTTERPSYDYVYLGSVLVFVVVVTGLFQYYQERKSAKILESFANMVPTFANVYRDGKKTEVATEKIVLGDIVEVHGGDRVPADIRIISAAGFKVDNSSLTGECEPLSRSADCTSDDPLESKNMAFYSTFAVEGTTKGIVINTGKNTAVGKIAHLATHLEQGKTPIAQELENFIGLVTVVAVCFGVIFFIIALFLGTYWVDAVIFMIGIIVANVPEGILATVTVCLSLAAKRMASRNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVSHLWYDRNSEVCSATSIAHTLTQLSISQFVATGPKDEAYFALTRIAILCNRAEFKPAQTDSPVLRRDCSGDPSEQALLRFTELMIGDISSIRKRNPKHIHETDDGVDEYLIVVKGAPERIVDMCSSILVGEDEMPFDEGVREDFNRAYLELGGKGERVLGFADLRLDKAKYPRGFEFNAEELNFPTKNLRFIGLISLIDPPRASVPSAVAKARSAGLNVVMVTAIARSQCDISEVDPKEASAIVVHGSELREMNEQQLIDVIRNHREIAFQQLGHIVAVTGDGVNDSPALKKADIGIAMGIAGSDVSKQVSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ02</accession>
    <name>A0A914HZ02_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ02"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5330.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5330.t2"/>
        <property type="gene ID" value="Gr19_v10_g5330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000832">
        <property type="entry name" value="E2F-like (Mammalian transcription factor)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR EFL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="136"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="293"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5330.t2"/>
        </source>
    </evidence>
    <sequence length="688" mass="76222" checksum="BF9C293BB812CE36" modified="2023-02-22" version="1">MFPPNISNDISSGHCATRHLNISRGAFTKMDGENEYIDVCGEGEDDENKENCDLRTVEGGPMDRRKFPKMPSLAEATCSSSKEPKNTREEFANGEEEQSDEEDGAETRSSLGGTSPDGAGRHEMSGTAKRRSGAPRKEKSLGRLCNRFLERMGEESRDGRDIHLESVARKMSVEKRRIYDIVNVMEALEAMSKTNKSFYRWHGLGQLPKLIHSLQSEAQLSNLPQRVDEVAKKMCTFVELSNFSPTPQSLFENDGKNDGIRRDSLTADGTPAPNCSELTECEFDEGIANRDRCGKNSLAQLCRRFLMVLLSKKSRKVSLDVTSTVLIKNPDKEGFEPPPRSKCRRLYDIANVLVAMRLILKKHALFGTKKIPLFEYCGPEPDADPAAGHLRMLEFLQRSGLTKIAAESVKAAGEEREMSDRKKENGSRKRKREFTAEINQTSVKKEADDPMQNSTEAINAKKAKCEEMNTKLPPMAVTIRQKTLPRPKPMMPPSFPTAGCFEVGGSSPAQQSSAIHSHHQPTPFFCPPRPPQQSLPFWPPQMALISTLIGRQTAQPSHLASFPSQNFPQLSPAPFPTFSAAPSSKTLNAVPVSKVRHSVQSILGVSQKENIGKMSPVAASEHSLLIAQSIQTGPSAAPKFQQFLMALYAAAAACFDLFTHFRTFAQCQCQQSQTIQWNKNDVSFSPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2024-03-27" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ76</accession>
    <name>A0A914HZ76_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g5847.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5847.t1"/>
        <property type="gene ID" value="Gr19_v10_g5847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5847.t1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40969" checksum="35BAC102C155CD4F" modified="2023-02-22" version="1">MSDNPKVEKRLKESDGNGAEIVKLXXWQWRSGGXRMSIPQEPFPDKVIGFRALTISYVDQSVLEFLQGICPLVTXKGSMFASKQRTSGRQLENXILDRILPLINANICALYLDSELYVVERRLPIPQEPLPAKVIGFERIMISAIDFLQSIRRLFVSDGTNLSIGTAASQNHSWQIIWHQIWPFVNENICDIYLSSSKLDRLRQFSPTVLRNCPKLQLIHSDYIFPEFPAVDDSARGASSKQAVAKWLHFPRGDGLPKMLRCSICQFDRPGQFHHLSPFLVFKGNDVPFKVQNNLTGERLVLRRFINRSKGLLVRCPIERDEAKWAEWEKAALGWKWRQWNRIEIYFNNNDISDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0C4</accession>
    <name>A0A914I0C4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0C4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5434.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5434.t1"/>
        <property type="gene ID" value="Gr19_v10_g5434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5434.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46728" checksum="639734BA5BA2BD32" modified="2023-02-22" version="1">MSSYPISDGINSVSDQQDNQTKPKQGQPDDEQQLIVDDAELNAFVRAYCRLCPMGMLRVLNWLLLLTLLIISLLCNWIPFNQSYTLQTHVAITLFLITSSCRVANLRLNKGTFKSKVRVGMLAIADLCASFLNVVGSLAIAFAFTIESINIYGQFWGKSEAELYFSDDRQRLLSMRMHFITDPAMAMVASAAVLMNVIQMICIWRAFKNANLLLSEYQQHFPHCSKSEAKYAKFLPFGLLKLLQWSIPSSALFLIIASYQYRNSFLQFSFLAAIILANFLSWLNFIATTHFRTNSNSFEQKSSLLSQCALDFVFSAINIMMSSVCLSNYASQHLGPIFYDIFCVYLFVSIGSLIASIVFMSKDMKCGRAYLSLPPISIQFSLRVGGKNAFELDTETEKKGEEFGKEENVPKRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0F1</accession>
    <name>A0A914I0F1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0F1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5455.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5455.t1"/>
        <property type="gene ID" value="Gr19_v10_g5455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052860">
        <property type="entry name" value="NRL-GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47521:SF7">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS EPSILON-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47521">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS E (EPSILON)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5455.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40422" checksum="E4C96091C7FBA04C" modified="2023-02-22" version="1">MSSSNSTLAFGYDFLLFTGGATELVINLVGMPLSLVNLWLVSRTSVIHPNMKFILIFQSCFILTRGSCRFLICLFKFLLWDPIGAERTSYLPAIRLAYYIGIYGRNFVPHILIVERVLATLTVKSYERNRRCLFSLLWSPMAATLAVFNALSAIRDDEQMPLTNLITTIAQFVIGTAEFAVFALLWRYNTKIYQKMLQKAEAHCLSERYQLSENIRIGRQLMPPLLLNLANILLGMIILVWNCVNLPYYWIMFMFCSNFNSFFGLLIELFIITCHPFLKRDFCRILQNFGNLFGLHFFGNRRVGEETGEPNNSAVVGLAQRDLISGRMLIERSKPDDHFAILRNAWERPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0F8</accession>
    <name>A0A914I0F8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7515 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0F8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g572.t1">
        <property type="protein sequence ID" value="Gr19_v10_g572.t1"/>
        <property type="gene ID" value="Gr19_v10_g572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055937">
        <property type="entry name" value="DUF7515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24359">
        <property type="entry name" value="DUF7515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7515" evidence="2">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g572.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30432" checksum="0D7401A5E1CC674A" modified="2023-02-22" version="1">MLNKPGQSKFDAEREIRRKPCNPFDFNCKLYEVLWVRAEGYESAAEIAHELYKRYEVCAVYFARQDGYETFEEMLHSDKLKHVVTVERIPFKPSYAIFHYRATLNNDNYVFAAIRKRLLQRKPSYTNGLYQDLNRRLAGLPSEAELKRTTESIATKERKYKEIRGEIFSYKVEIGSDDEGMDGKGEFAFEDGDGWEEWAEEEGEDGDSSGGSVIAAGNDAGGVEKAAHSMAKAKLLSSGSNPKGMKKLLNTEWMTEDDNYNFDRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I199</accession>
    <name>A0A914I199_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I199"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6365.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6365.t1"/>
        <property type="gene ID" value="Gr19_v10_g6365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6365.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8736" checksum="878029BC11AD1E40" modified="2023-02-22" version="1">MHFSDPYKANGNILLTIEKVSEFARGHDKNSSGRRFSDAVYIRGLPWKIYAIPPTVSAQKHLGFFLQCNSDSGNLAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1M8</accession>
    <name>A0A914I1M8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1M8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g605.t1">
        <property type="protein sequence ID" value="Gr19_v10_g605.t1"/>
        <property type="gene ID" value="Gr19_v10_g605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038160509" evidence="17">
        <location>
            <begin position="19"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="23"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="235"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="463"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g605.t1"/>
        </source>
    </evidence>
    <sequence length="609" mass="69354" checksum="628D125705905C6F" modified="2023-02-22" version="1">MLIMSLLCVCQLVQFSGSDSMLTDLFHSLFYDYNKEIRPVIEHNRPVNTNISFSLIQVVDVDERNQLLTTLAWIHFRWNDWRLAWDPRMNGWITKLKVPIEMIWKPDIILYNNAASEYLNEMSTASVTYDGNISLSMAGIFKSSCELDVRFYPFDFQNCLMKFASWSYDGTKIDIFSGPSGDTSNYMVSTEWTLREVRATKNSVIYSCCSEPYPFIDVYLLLERKPLFFVIFSCLPCVLISVLVLLGFYMPSDSGEKVTLGITSLLSTTVFLMLVSEHLPPTAEALPLIGIYYGVTLFIVSLQTAFTVFTLNIHHIGTHGPPVPRLLQKLLFGRVPRLLLLNLEKQYHSINEHVHYFIGKQTMEERDQRDNTNLLIGAQRPPPSSVDQKGPIGEFYRWKRRGRSGWIWFQGAFCGRFKLFAESEEEASVLHGQSQHLLPAKKRHVHKHHPNCAKIRVATVSNVGKRPRSVDQLSLRRRRSSSLRSTALTEETTGKECEGAGEEDAPIEGGRDNGTSFESEFIGVIGGGRDNGTSFESEFIGVIGRLQEVIERNELRLMEKDRRNAEKLEWQQVALVLDRFFLVLFSIGTALVLVLIVFSDQTNKAIFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2Y1</accession>
    <name>A0A914I2Y1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914I2Y1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7009.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7009.t1"/>
        <property type="gene ID" value="Gr19_v10_g7009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7009.t1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38764" checksum="F970C5FE1551B118" modified="2023-02-22" version="1">MAEQLAVELVSLRAGVRVSDRWTIIEKLGPAEHGAVYLCHKDYGMVAAMKTERANTEHQQLVMEANVMRSLDKLSEGDNKHFCRCLELGRDEQKDVQTGTMKPFNFIRVADGLVREAGGRFSPGTAIGMALQLLDAIKALHSVGYLHRDIKPANTTIGRPESNEQRLLYLIDFGMARKYVREDGSHRRPRTNSNFRGAPRYASISAHIGRDYSRKDDIESWFYVLVELYTGMLPWSGTGDMREIGDMKRLRSNNQPANIQRQAVQHLLSGCPADCGWGGILRHIDELTFDDRRNYDMISSTAQHPLQAEHSGASVRLGGGRTLSRRRRRSIRWPVIYFVPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3N5</accession>
    <name>A0A914I3N5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3N5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7204.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7204.t1"/>
        <property type="gene ID" value="Gr19_v10_g7204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7204.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27348" checksum="2D88AA187DE80246" modified="2023-02-22" version="1">MATDCVEEVQIEPKGLLGLLGVPPGARAVVVFAHGSGSGRLSPRNTHVAAEFRRAGLGTFLLDLLTPQEELDRHNVFDIPLLAKRLKLASEWLRSRPRTATLVQGYFGASTGAAAALMATAALTDTSAPIGAVVSRGGRPDLAMNVLDRVRAPTQLLVGGLDGPVIGMNECAFDALVNCTQKELQIVPGATHLFEEPGTLDEVVRHAKEWFLKHLHIRAQWDLKYLDRYFNIYRSLFVKLFLPSKSLISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3N7</accession>
    <name>A0A914I3N7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Papilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the papilin family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7014.t3">
        <property type="protein sequence ID" value="Gr19_v10_g7014.t3"/>
        <property type="gene ID" value="Gr19_v10_g7014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000017">
        <property type="entry name" value="papilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1152"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1213"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1333"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1442"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1536"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1593"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1748"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1807"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1890"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="1978"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="21">
        <location>
            <begin position="2113"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1277"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1392"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1669"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1807"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1279"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1406"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="143"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7014.t3"/>
        </source>
    </evidence>
    <sequence length="2153" mass="235813" checksum="0C028A2CF0251A2D" modified="2023-02-22" version="1">MAFERCKHWQYKERPHKVPSFCDNIALEVEMTSFSAAHWHFVFLLPLLLLSFVPLIALASASSEAADDGAVPLPLHPSSPPHRQPAQQNRAKRQAYQVYLGNEVSVSVDRGQVVDEGPWGAWTVERQCSRTCGGGVYVERRICGGGGHCAGPSIRYISCNLEPCPADAIDFRAEQCAAHNDDPLDGKYHKWVPYAGKNKCELTCRPESGSFYYNWAEKVIDGTKCDAYGQEICVDGICLPVGCDGKLGSEAKLDKCGVCQGDGSQCKTVEGLFDERALPSGYHDIIALPAGATAIHVEERRPSSHVFAIKNATGFFFLNGNFQIQVLDKDIVAGGAPFKYGKGDSGTERLTAQGPLQEPIIISLLLQHTGAKQIAVKYEYSVPLEKDVKFLYKPGEWSQCSVTCGRGVRTRALYCIDTATQARVDDASCEEHNATKPEFEKKCVTVDCEPEWFVGKWEPCSTTCGDRGVQFRVLYCHRVFADGRRITVSDANCTEERQLPRPDMSQQCARWSCPEWQAGPWSACSSQCGDAKQFRSVTCRSAKDGEEGKLLPAEACTGSKPSTERDCNLGPCEGLRFHTADWELCQKCNDTEETRAVNCVDKNGREYPLEKCLDGKKVTKIPEDTRPCASQAPCIYEWHTSQWSKCSTECGHGHTQRKVFCAINELGQTKRVDEALCGQSADEKPVARDECVNEEKCTGTFFTGPWTNCSAKCGGGTQTRTVVCLNYDRKPVPEWCDEKEKPPEEQECGMDSCPKCADSEHGCCPDEETFASGPFLEGCSNCSVSDFGCCGGDNMTAKTDEAGTNCKEFTEPLGGEEGSGEEPVDAEASSPTDGKALCEIVNQDTMEKFQIPCADTVLAAANETVELLKMAEDEAIGGTNATDGEKHCSKSEFGCCPDWSTPAEGPNYAGCPKFVLGNCNGTKFGCCPDEVTMARGLDFEGCGEPTCAASLFGCCKDRRTIAFGPHYAGCDRSSFPCELSPYGCCEDGETAALGNNGTGCGASCLLTKFGCCPDGKTHAKGTHNEGCGCEYAQYGCCPDGRKAATGPGFYGCPEGCAQSKFGCCPDGKTIARGANKEGCPCQYTRWGCCQDGETTALGPLNEGCDDCRYAKYGCCLDGVSKAIGPDYAGCPTTTAAPFIIGGTVSPTQIVSCSLPQDQGQVCHPGYQLVWFYDIAEGRCSQFWYGGCAGNNNRFANREQCEQSCIEPPHLGRCYLPKVEGPQRCTQLAARYWYNYVTKQCQAFWWRGCLGNANNFGSWEECQKFCELADATQVQVVMPQPQPQQPPQPPQQQPPPVAPPPVQPQAIQAPLQPAPQTVAILPPGLEEAGELDSCRLNVDSGNCQNYMDQWFFDPYSGACFLFIYSGCGGNRNRFGTEAECIRQCGHLRKPKPGFLGQKQLPPPTPAPTAVAVPPQQQQQQQHKPKVEKMTTGRKALTKSRDVCNLRPDIGKCEGHFESWYYEVASGQCEKFEYSGCGGNANRFNTPDECQAVCLRRNDFPSPQRPGGSVSAPAPLGPGNLEQSLPIIGDKQHLAHICDVPKDSGACKTFITKWFYNMRDGTCVRFHYGGCDGNANRFDTEEQCKNTCGNYKDTCHLPKVVGPCEGHTPRFFFDLHNRQCLPFEYGGCLGNNNNFRTLEECQARCRPSTTTTNPSPVRLTRANPMPVTTAELLEDDDDNDTTQQNRRNDQTRPSQQPGGDQNDHFDQSAVNGGIVNEEEEQDEQQQQHMDEDMVVVPREHLLYGQLPELCLLPEQRGTCFGEQLRYRYDTSAGDCVGFLFSGCAANANNFASYEACARACGPWKAEPVCEQSPDEGREQCNNGRRRRRRRQNDMAGANVPKWYFNAALGKCALFFWSGCGGNGNRFQSKSECENLCQREILARTHRRTGRACAQTMDAGPCEDLVTMWYFDAVQEQCRRFTFGGCRGNANRFVARADCESQCVAAVANTSGDSHLNANDNFGVPQHLSRQSAHRHQHRRPRLFAFPVGTLLVGTSTLTLKCVADGTATPKAFGGNEANGEEEEEDNNFTWYKDNQQMLTTQADDATEQQQQEQRVKFFESVTTHAGGGEAAVVGELRFRSVRLMDGGAYSCAFGDASNALISEPVIVRVTEADPSLTLCPGDNGPAHICRTVARTGLCSTLRYGRYCCRTCAIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3T2</accession>
    <name>A0A914I3T2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914I3T2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g634.t1">
        <property type="protein sequence ID" value="Gr19_v10_g634.t1"/>
        <property type="gene ID" value="Gr19_v10_g634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="481"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g634.t1"/>
        </source>
    </evidence>
    <sequence length="892" mass="103473" checksum="7A071B904B2F7D4E" modified="2023-02-22" version="1">MASSNLFLKAINDIRKEDGVRELGTILAPKGKLSLFYALELARNYQMIGNENTNDKFRYFMKQEKKQQETVSELMRKLELDGNEKKYGIEKLESVQAFWDTAFPGMFRIVAFDVRAGLKPIFKGNGVRKYEVCVIANKGHWDGIKSAKRFFNVRNYCVSCEVSYDRPERHSIESHKKQACKEYKKCKKCGEVSQTRSKHVCGGKFCKLCKIYHQGRQCHIQKIRQKQILPRYRIVAYDMETTANEAGEHIPNLISAIVTCSECEGQKKNTCEAGYEKFVVWYEENKNSEFELGEQLKIYCENDDTETPNGFDILKSNITIASAAMGIFRAKFLKERHIPIVSEGGYEKADNQSVIAVKYFEWLAHRDGVKVRHACNGGEVQFGGYKVDCVIGEQKKIIEFQGCAFHGCPRCYRPWTKSPDGKSMEEKLLRTEMKMDNLRELCKSFSVEEVWECDVRAELRRNREMKKFFESVPDKGPINPRDAYGGGRTMPFCLYAQESEEEEISMFDIISLYPAVNYDTPYPVGVPKIVKRDEDVLWTEPDDVPYDGLLKVKVISPKKLKYPLLPVHLDDMLLFPNCGKCAKNEKKDFLMLKDVKKCRHSSEERAILGTFTSIELKKALELGYRVIHFYRAYHFEAFDTQLFKGYVRMFLKIKVEASGWPAEVKTEEEKRVFIAIMEEWQKILQDDKLETSEPIMLKDKKTMRVSIKKKEAFVVEHRVSNIILSLWTTSAARIKLYEYMEQVYRTKGCKLLYCDTDSLIFTHPRGVCPLKEGKFLGEMTREYADNEILEFVSGGPKQYSLKLRSKTNGKVWQKTKIRGITQTFNNKIDFEELKSMILEYKEGETMTFHYPGKFGPKRDGRIISEDLAKDYKPVQKKGIIDQEWNVLPFGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3T7</accession>
    <name>A0A914I3T7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3T7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6342.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6342.t2"/>
        <property type="gene ID" value="Gr19_v10_g6342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037665308" evidence="1">
        <location>
            <begin position="22"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6342.t2"/>
        </source>
    </evidence>
    <sequence length="308" mass="35411" checksum="DFC28ADF30CA56DE" modified="2023-02-22" version="1">MFKVWFLALLTLSASRLNSSGKEENKQDQKYYETLTNKDCDVHYDHKNGKCAWRNEVTQKYERPALDYEPFGDTKCLGDFHNRIFTHVCGDPLYEQIKYCAKVKFYKNKKPERESTKNNILLLLLDGCTATLKLTYKLPAGSFFTACAEQTKEAESFSISMGSSADGGIINKDAVSNDYEEEDTIVEKFARNNMLTFALPALLVERKNVTLTVEHKWVTNHGRDRPACTNFRSLAFSCKTRKSKSPMVLQLSDLLKIDKFKYNLAEVRRLHINLGENIFKQFSPLNNEYNIADSVKFENLAVPKNDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4E3</accession>
    <name>A0A914I4E3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4E3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7407.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7407.t2"/>
        <property type="gene ID" value="Gr19_v10_g7407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7407.t2"/>
        </source>
    </evidence>
    <sequence length="74" mass="8781" checksum="6C92FF8BEBB984AD" modified="2023-02-22" version="1">MGREREHRSERKRDVEKDQSPADESSSGGRKRTKKEKNRSPSPPRSRSHTYSPSPRREISPKRRARRPFCSKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4Y4</accession>
    <name>A0A914I4Y4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4Y4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6928.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6928.t1"/>
        <property type="gene ID" value="Gr19_v10_g6928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6928.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11949" checksum="0D2526597672CBEA" modified="2023-02-22" version="1">MKRATGRLRLFGWDEKTSSTATSATSPRSNYTYVWATTARFPYSAAFQSISSPRSNYTYVWATTARFPYSAAFQSISSPRSNYTYVWATTARFPYSAAFQSISINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5B4</accession>
    <name>A0A914I5B4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LAGLIDADG homing endonuclease</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5B4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7027.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7027.t1"/>
        <property type="gene ID" value="Gr19_v10_g7027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7027.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32314" checksum="6B3DC3362CD487AC" modified="2023-02-22" version="1">MRTNSVTIVAKKTLNLPNELEHRSYSTSSALAHFSMSANFSQLSISPTRWTLWRFDCHDLPNHCSSVTCPFCVEVNKLRLLSNKDNLDDGHDRWETYLERVNCFDNQQTLLRVANAFLPSKLAKSVFFNYKLGVAIFRENIPPKYESAKNIDGGIFELQLATSSGRLSVETVQKFDALFSQSLSLMFGLPFPIACHVHGLFYRCEVNPGKKRLAYRNQMDLPFIAKLEVWIDHQQHKTLVKESLINAIKNVINELEIPILRSFHFRINYFRARNLKNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5V2</accession>
    <name>A0A914I5V2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5V2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g760.t1">
        <property type="protein sequence ID" value="Gr19_v10_g760.t1"/>
        <property type="gene ID" value="Gr19_v10_g760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="41"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g760.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22738" checksum="11D834F7A95B88D9" modified="2023-02-22" version="1">MLAQHTHISLTLPAHNVLTAPRKPSFLTAHPFRMSIIPFLSNIRESRFLSNFYPAHLTYHNNHFQSSEHCYQSQKAEFFGRMDLLELINASRRATEQKRLGAVAQRSASPGRVARWHDAKTGIMREILAAKFENPELAQRLINTGCALLVEASPSDRFWGAGASYSQVLEGRFSGRNVMGRLLMQLRDRLQKGKQVPPATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I636</accession>
    <name>A0A914I636_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I636"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g766.t1">
        <property type="protein sequence ID" value="Gr19_v10_g766.t1"/>
        <property type="gene ID" value="Gr19_v10_g766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="2"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g766.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12659" checksum="42E1F528277C3D4A" modified="2023-02-22" version="1">MDLSAQVEELFFKLVDDNNDGIMSVQEYERGLQSLMKGGSAVLDAFSGMEKGRAFEEELRKSIGPKKVAEYDKNGDGWVTLDEMLQQIRVEAQKADTDGDGTISKEELRQHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6F5</accession>
    <name>A0A914I6F5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Olfactomedin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6F5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7745.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7745.t1"/>
        <property type="gene ID" value="Gr19_v10_g7745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF35">
        <property type="entry name" value="OLFACTOMEDIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="6">
        <location>
            <begin position="192"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7745.t1"/>
        </source>
    </evidence>
    <sequence length="522" mass="58348" checksum="69EE7D49FAF4EC55" modified="2023-02-22" version="1">MSSRSPPPALLPPPVQHYANPHNFVSPAAAEDLSSMKQRPLLFLFLLGSLLLVSLSFNAFLCAELWWNDGTEQLSEGCSTFLYSNLHRPKRQIEENDGILMMEYAVNNQPSKSAEIAAEGKEEEDDMPLFVPLYTQMSQKFLNKICHEKFGRQLQNVETGEESPSDTEHNRTKQKKPLRTKGHRRKSYREKVCSPIHSLGAPRFMARRVHQRGSAMRRGGRWFLTEYDTGYTLFQFDLPTRGKNETVNAKVAKKRRHLAELDTEMADEGGVELAFPSQILTLPEPFRGSDHSVGGAKGDETFFYQLASGGRIQALHLRTGKRLSKLVYAAKHPLYGSAPTAADEGQVEFGGSPPMASSVDLEVDQSALWVLFRRPNLSSSSGRPLPHLTVLKLTPDSLKELGQWELKQIMADQMSNAFVACGQLYGVTEAQMRQSTNSDPTNSFSPSLHIVPLFDFRTGHNLSETALPITAPGWTASGRNSISNVQYDAVSDSLIAFDRGNVYTLQIQRKGINRLHQRQTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6I3</accession>
    <name>A0A914I6I3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6I3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7768.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7768.t1"/>
        <property type="gene ID" value="Gr19_v10_g7768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7768.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31685" checksum="FA4F796F22190C20" modified="2023-02-22" version="1">MEQIAQQPQHKIRQKKRKKLGKHPKTENDNVGLLPEPREGPSSSSTPSLPPPYPSSPPATTTIHHLLVSKSPYRHRYHHHHDHPHPSSPPFSSLSSSFLGPSLPRFHFALVLLSLCIISVTIICAFGCYFRILNEQRRNRRQRRQPNACRGDSSSNIAEKERLARVNKFIVRSSNGTTSTLTNGPTSTSRVQQQPMGANAYPQRIVPKITITSSGSECDGAAIFGHLSATRSPKAQPLEKEIGRKNDEILAETAVDDSGGAAVGRMRPEEFIQTMLEKVERERGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6X6</accession>
    <name>A0A914I6X6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6X6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8067.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8067.t1"/>
        <property type="gene ID" value="Gr19_v10_g8067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037343446" evidence="2">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8067.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26058" checksum="E62ABC4A65798F88" modified="2023-02-22" version="1">MDVSTFGLVAFALSFALACSGLQSLSLFGMDKQASLEKCIPKSFNTFFQEDKADIEKCPKMLKCLQRKHSNILTFGICMPKDLTEKECNAPLPPIECSNLCLRSRCNALLAFDAVCAGIAFVCNIVTFGVVSGQKFIKLRQCFWRQFVPTIFMNLLLNAMLAVGIERLASVVVPFFAHKTFVEPIRIIGRHSMKSSSDQQNKLNFWQPLLALKPATLWRQHQTACKMYAETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I881</accession>
    <name>A0A914I881_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A914I881"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7547.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7547.t1"/>
        <property type="gene ID" value="Gr19_v10_g7547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF2">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="17">
        <location>
            <begin position="353"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7547.t1"/>
        </source>
    </evidence>
    <sequence length="664" mass="74785" checksum="A1C2F413D3165FDD" modified="2023-02-22" version="1">MPSLQAFGRHWNIASDDFVFPGLTDLFARGAWVLISVAIFIVHNPFECNSVSWLPLVVVMLALNIVSAGLSISLALLSAQGSVMNTERRRHVPMLLYARLPIFLTEIAWTAWTTLIAFNVLDNASHMCRISTGIRIAVVLELFLVFSTLFGVFLVFNPIDGRRMDRSMVDERLYWRKRFFLCKMGQDSLVREAIDDIATLVAFYFVDTDFVLSDIIAGLLLLVHSPNKRIPPSLDSLQSVVKSRPEWMQIPNCLEMANRYLGFSVAVYGWPFYVLTNCACYSWCLLCRQLCNTSKGVASDEFVVVADNCCSCHRSAFMLRLDADCRLYFLSLRNRLFEVPFAVLVDDKTRAVVIAIRGSASFMDLITDLSLSDELLGNSVDVDSDPILRNDKELDGRGEVRVHKGMLRGARYVYETLMSNHVLEDLELKYPDYCLVVCGHSLGGGIGSLLALLLKAKYPDVRCYAFAPPGPVISENGIPDTERNTLSIVLGDDVIPRMTTHSIHLLKQEIEREIVSTDRAKYEVLIKGFFKLFLAYPFELHSTSADTDTVSTRNLCRAESAIVPPSLLQPPSAEQWRDGAGIRHLRPPGHLLHLAYNDENNVELRWIPHTAFYEIQLNASMIRDHWIFNIDKALSKAANAFVNAGGGNEHQQQQHDDRRPIFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8J4</accession>
    <name>A0A914I8J4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activin types I and II receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8J4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8474.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8474.t1"/>
        <property type="gene ID" value="Gr19_v10_g8474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8474.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28598" checksum="852475475EB88E37" modified="2023-02-22" version="1">MTPAAKNNFVYPPRAATPKHCLRRRHHQISAPLLFGYCAILLILLCQHLPITLAILFQEDDHSAAGTRCFCDKKNCGGGTLVCAGRFCLIGVRNEDAADGQGRLDQHCLEEDGALPQGKGCARDWRQWSEVCICEENLCNTWAFLRAQMDSPISVGANFRHHSLKVGAPAERSVHNALAPAHLAAEGQRQWGRAPYSDEDDDDADPPLARETDPLGFGRPDDAVRQRRGPALVLLLVVLPLVVGAFTVVLVFLNYHCNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8T8</accession>
    <name>A0A914I8T8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8T8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7693.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7693.t1"/>
        <property type="gene ID" value="Gr19_v10_g7693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000458">
        <property type="entry name" value="E2F-like (Mammalian transcription factor)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="10">
        <location>
            <begin position="298"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7693.t1"/>
        </source>
    </evidence>
    <sequence length="602" mass="64996" checksum="4C0370E2E6D73C7C" modified="2023-02-22" version="1">MYIEIYQFYIPTFSCSLVWKPRYLETFRKNSLGAGGVNRTPKWPFLCKVSPVFAPWIFISVKMRSSVLIIFGVVFLITLLLSFSEADLTVDSLMPRAKRQCCDGCGYGGGIGGGYGYNNGGGQCCDACGQCGGGGYGGGGNGGGGYGSGGYGSGGYGGGTVIITTGGGYGDGTCYSCGSGACYGCCGLLSGSFVQVGLRDATLIFPRMDLHPTDIAYSPTPSSSSFAPQPSIASSSDSFSSPIPSDCAAFGNSPSFGCFQTQQPAFQTPQLKCRRSNRYTDTPSSGGRRVYSDEDSSRQDSSLLRLTQRFLDLQTKAGILNLNEAAQLLGVQKRRLYDITNVLEGIDLVEKVGKNSIRWKSQNEFFCSSEFQSLNKENAELVECERNLDVLTQSISAALKLSKEDPTDAVYFYSPFSDIRSIDSFTNKTLIAIKAPLEPQPRSSIEVPNPYDTGRYEMTVRNENGGPLLAYLCPDLVDKSATEFAPGNCHTNTAVCEKAEVGKKLFVDPPQMQNVSGLKEGEPNEWCRSPSKQQRMLSPLKMLFSNPQPQPDALSSNSVAGGHFPAPGEAVLSLDPLEDNDPYYLLFMDKQNMSLNSLFSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8V6</accession>
    <name>A0A914I8V6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THUMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8V6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8574.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8574.t1"/>
        <property type="gene ID" value="Gr19_v10_g8574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="112"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8574.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29420" checksum="F7EFDBCAD847D03D" modified="2023-02-22" version="1">MNNLKPGLCGLFFTVDADEKRGVREAFNLIDRFISAEEASDEAANSCNKNAESDGKDVSDSLSSECQQIRQKRQHFASNTIRQFGTGARCSLFFTSARICPANVYKIAVKMVEQSQRESLTRFLARVIPVEETCAANLDQITTLLSEMIAKHLKDAIGGEPPNNASPTYAVDFKASNTKLLKREQIYDLVADLMKKQSPDSAVNLTQPDLLVVVHTIRTVTMLSIVTNYYQLRKFALKLPSEKECKEKSSKETADAEPEGKTEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8W7</accession>
    <name>A0A914I8W7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8W7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8364.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8364.t1"/>
        <property type="gene ID" value="Gr19_v10_g8364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037586196" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8364.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7627" checksum="C9F894F6AD4B1EA1" modified="2023-02-22" version="1">MAFCQFAYPLSASRHLFVLLLPASASQKCLGQRNLCNTRTRADDDRLGATRRVRVGITHTSLGQFRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA37</accession>
    <name>A0A914IA37_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IA37"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8695.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8695.t1"/>
        <property type="gene ID" value="Gr19_v10_g8695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF53">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 11E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8695.t1"/>
        </source>
    </evidence>
    <sequence length="679" mass="71737" checksum="DDFB7563D9F52B9F" modified="2023-02-22" version="1">MRMNAVSAASSAPNSLAISDSAELLAVVDASSPTCSAAAASNGDGTVTSPTQATTIAVPVVESVCMPVDLPAGTQIMVETQVLTSDVDQTVAEVEKLDKEARIIQQVEQALCSIGGPSASDEGAAERLTMSGGGRRLSVLIPPDERRHHFPIVAEEGTAGQNGTIAMESGGSVPQTAGNASAGGGQSNRTLFCRKCEGHGFQRALKGHASSCPYNNCTCKTCKNVMSLRANAIIRRYRTRTNECGLVLKPVHFKNGNTRLRVFPKFISEDECLPIPPPASAGELLRARDCSGGHGAAEEQAEDFNDGASLGHKTLSLRNLASVGGGSKRFSTAEDEDKRSASSPKRANSYDGNFVELFTNASVSGSDDTAIVPAGLHLLPFALPTYSSEASARSHTQSACLFAKAPNRNDHNRVNNLELQQNVLTLNSGHNNTTKFIVSCASQLRPHLDHLDKRVQQPSTEDGPMNSSTNTVANIMTTTAPAVAAADCWSGQLLMMSGQQQQQQQDQSQWTQQQTQPQQHQHIQALLSQLDPALLVQLLAPFTTTHQPLLSPPAQTSGPSFVFGGGQNSVPEGNGGPFGMPTQTAAGIPNFALSQQPPSVSAAPRSSTAADCDLVPPIRLTETLALAPDASHWLADPHFRQFVAIVGQLERHMLGTSPRDQTPAASQNKNGPTPPPFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAE7</accession>
    <name>A0A914IAE7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAE7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g837.t1">
        <property type="protein sequence ID" value="Gr19_v10_g837.t1"/>
        <property type="gene ID" value="Gr19_v10_g837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g837.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10341" checksum="B0C440663C4F7EE4" modified="2023-02-22" version="1">MREAEKKRIERQNSSKRGVSSLKAEETTDALKERIGDDERMRYGRAALADGGAALKKILHHGYQTTRSVIGQPMLFLLLQRPLLGTMRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAV1</accession>
    <name>A0A914IAV1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAV1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8483.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8483.t1"/>
        <property type="gene ID" value="Gr19_v10_g8483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF12">
        <property type="entry name" value="POLYMERASE NUCLEOTIDYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8483.t1"/>
        </source>
    </evidence>
    <sequence length="494" mass="56211" checksum="AB6105D45453FFDC" modified="2023-02-22" version="1">MPKSVPRLCSSVFKNVSPLHHSAAFASDSPSPSSSSPAAAALPLNEVKRKYSAEIDQLSASITEFCSGSFERNRELHARVRPVVAELERAVCDAGGRSRLALIGSIPSGMAIDASADIDLAFLYTGGSKEQRERFLNDFWAKTSNGFVRIFMEAIAEALTNFCDAHPSSDYRLSKPPAVIVQTTAPVIICRMDNGLNMDIQFPRADFQAVRNTLMVRYYVQTDRRFLQLFHWLRRMFQQMGLKNSKNGLFSSYHVLMLVLHFLNRKEVPNNVLPALVQFPAHVRDQLFAPNVSDIVRRLEEPPSLERFPFWRNKCSKSVGELAVELVDYYALFDPQKRAISIRFGRLQHRQRKYGPWLNVFDPFHPKSVTRSCLHAEALVLGFQFLRDQMTEGKHLATFPLLNGLAEEFGEHARQRGIRWTKSLNAHVDVHTPLDDFEQSPEEQEEDGEEMDEEVNDDDDDFKQSLEEQGAGKVEGEVNHDKFKQSGGLRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBV2</accession>
    <name>A0A914IBV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bardet-Biedl syndrome 2 protein homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBV2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8441.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8441.t1"/>
        <property type="gene ID" value="Gr19_v10_g8441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016616">
        <property type="entry name" value="Bardet-Biedl_syndrome_2_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029333">
        <property type="entry name" value="BBS2_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055380">
        <property type="entry name" value="BBS2_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029429">
        <property type="entry name" value="BBS2_Mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029430">
        <property type="entry name" value="BBS2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055379">
        <property type="entry name" value="BBS2_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14782">
        <property type="entry name" value="BBS2_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23353">
        <property type="entry name" value="BBS2_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14783">
        <property type="entry name" value="BBS2_Mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14781">
        <property type="entry name" value="BBS2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23350">
        <property type="entry name" value="BBS2_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013684">
        <property type="entry name" value="BBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 N-terminal" evidence="7">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 middle region" evidence="9">
        <location>
            <begin position="161"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 GAE" evidence="8">
        <location>
            <begin position="431"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 platform" evidence="10">
        <location>
            <begin position="523"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 hairpin" evidence="11">
        <location>
            <begin position="635"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8441.t1"/>
        </source>
    </evidence>
    <sequence length="768" mass="83907" checksum="CD5085F95296C4CF" modified="2023-02-22" version="1">MSAVGGHQQQLRAAFSFGFAHRLAHGGGAAGVFDGSGREQLAVGTETGKICLQAIESMFNINEQITCLAIYPRTRTDADHYDVVLVGTTSSLLALDVYNNRTLFHRHMPEGVHCVRVGHVDAHRDSHVIVCGCGTTIWGFHLDGSDVFWTALGDEVNVVELCDMDGDGQNELIVGTGGADIKVLKNASFFAEFDEGDATTALCALGPACFAFGLDSGVVGVYANGERLWRVKTKSPIVALLQFPARARVACRLNVFFKFPIDIRSASTGEIGAREQFEDGGELSAAFLADLAGTGPLDDGQPRPQLTLVFCNGQVRALEFRNELADEKGQLLRNISQRKHALLEELKTYDRHGSNASAAEAGGSGGVAECSLIPPGTMLTCTLDLMSAAEQQEHAAATAAAASSSSPTNDITAVTVMSSSSSNAHASRNASGDSLCVRLTLSNSVPIRAVLLFADGIFDSECIAIHPNGKESAEMVVQFNPVKNVHANLFIKVFAGYSIERQLRVFAADLELPRFVTFVQVEPTFSETPEAFVAFRLHCRENKLRQWVCKNFSFICEQNVDTDEAETDQQHNNNNSKFQLKFMCMRNQQPLLLELDTAGGNVELRHNDIRNAADILQSLCAFLGVRALSSRAHFPQVLDAVKSVVENMDRRYEVNERLASEFAERLNVVRECVVRAEDALAIRNFAESRRLYTRVTMLNRELCGQQTIWMAAKKELLDAMKFLNVSIEQFSRLRVGAPGASLVQECRKAIAGDKLDIVPKLLEFGVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC57</accession>
    <name>A0A914IC57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8845.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8845.t1"/>
        <property type="gene ID" value="Gr19_v10_g8845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
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        <property type="entry name" value="SLC12_C"/>
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        <property type="entry name" value="SLC12A_fam"/>
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        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
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        <property type="entry name" value="AA_permease"/>
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    </dbReference>
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        <property type="entry name" value="SLC12"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="434"/>
            <end position="454"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="488"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="699"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="237"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="8">
        <location>
            <begin position="785"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
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        </location>
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        <location>
            <begin position="190"/>
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        <location>
            <begin position="1021"/>
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        <location>
            <begin position="75"/>
            <end position="88"/>
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        <location>
            <begin position="98"/>
            <end position="107"/>
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        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
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            <begin position="947"/>
            <end position="956"/>
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        <location>
            <begin position="1033"/>
            <end position="1044"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="6">
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Pfam" id="PF03522"/>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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    <evidence type="ECO:0000313" key="10">
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        </source>
    </evidence>
    <sequence length="1286" mass="142842" checksum="4703FAD9B948CBDF" modified="2023-02-22" version="1">MSFSSSDGEQDLEMCQPKSPKSVGKRPKGEEGALPGASSPVAGKPRAEPAQPHRRFKIKRACMEPRRQQQQKIHPTIDEGHAAEHKEAAGSQQSQKEAPAHAKDRRFSRGGTILEHPPNIEFYRNTLEKEVSGTVRPSMMDLVEGNKQHPQQQQQQQQQQQKQESQSNVEMFRERNVQILEGQQRAVGAKLTWRNQPRRTESDSSKKSLQVQRRAPRPSADAGGDKIKLTKFGWVQGVLIRCMASIFGVMLYLRLSWVSAQSGLLLGSCIVLLGTLITIITTLSTSAICTNGLVKGGGAYFLISRSLGPEFGGSIGIIFSIANAVGAAMYLVGFAETVRDLLKHYGIFLLDGDINDIRIIALVACAILVVIILVGLSFESKMQILMMVLLWVSILDYFIGTFIPPSEEQQRKGITGFKMETLKENLMPQFRDEYNFFTVFAVYFPAATGIMAGANISGDLRDPQSAIPLGTLVAIAITSTVYLLMVWLTGSTVVRDSDGLNVPLLLMNASREFIFEQISSQSVQLVSQQFNDSLSTNSPPMAHQVETLSSSPLYYAPPQCAYNQSCPYGLINYFQIVELGSAWGPLVTVGIIASTLSSALVSLVGAPKIFQAVCRDRLFPYINRFGRGHGPNDDPRQALFLVAAIAVSVILIGNLNLIAPLISNFFLCSYALINYACFDNSFAHSPGFRPSFKYYNMWVSLVGSLMCVFCMFIISWWTALLTFFFFVTIYMYVAHRKPDVNWGSSGQAHSYRNALQYVSKLERTEEHVKNYRPQLMVLTGNPAARAGLVDFAYSITKGSSLLMCGYVIPYKACNTVFMMMQRFNQQLRDWFVVRHMKAFAVTVANPNLRSGVQSLLQIAGLGKLRPNIILMGFKSNWTQPKPLTDNAMTEITDYFGLIQDAFDLNMSVAVLRNSAKGLDISEFILETTEDLCQHQRQLCISRRGSYPTEQHPSQQLNTAGAQNAQQPAAVVPIPTQSNARQRARDLLLRAIGQREKTTGGLTVQSTVGGLGEDTLQTTVGQAEGDTMGGTTRGWLTNSDTVTRKGSQKDDTGAEHLQLEQQFLPPLPLPSDALRFQTRVRHGTIDVWWLYDDGGLTLLIPYLLAQQKSYLENAKLRVFTLAGQGKNLQHEHQGLATMLKKFRITADQVNVIPDFTSKRPDAKSLAKFDALIKPFMRPIGRRETNMTTVQLESGDENGDANVDHFVGLITEAELNAQQERTWRHLRIAELLRRYSTDSDLVVVTLPVPRRGLISAALYLAWLEVMSAELPPTLMLRGNQQSVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICE1</accession>
    <name>A0A914ICE1_GLORO</name>
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        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
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        <property type="protein sequence ID" value="Gr19_v10_g9318.t1"/>
        <property type="gene ID" value="Gr19_v10_g9318"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
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    </dbReference>
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        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
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    </dbReference>
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        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
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        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
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        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="17">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="18">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="19">
        <location>
            <begin position="501"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="1058"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1390"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1857"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1390"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1406"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1857"/>
            <end position="1866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9318.t1"/>
        </source>
    </evidence>
    <sequence length="2175" mass="250828" checksum="9A4173DB8E065B24" modified="2023-02-22" version="1">MTDAIMQQLTQVLQQMLTNQQQNVPPIASVQPLPSLPNVECFEPAEDRSIADWLDRFNFALDCAAPQLADDKKVKLLMTKLSEAAFGQYSKSCLPKKVTEFTFTKTEEHLKAAFGRPQSIWIDRYECLRASRNEDENFRAFINRHKRLLRDFEFRKLNEEQFSCLMLLTALKAPKEAELRKRILSKLAADGDRVKYDGVVEDLQMYQSTIAEAKVIEQPASSKNLFAVRRKPFPVQKGSATQSPTQRVCWRCGKSSHPPVECPHTKTVCRKCNKVGHVEAQCARHQEWLNRNKGSKNTGKRACTLRMGGVLVNVLNQPTKLIEVPVSVNGSDVNFLLDSGAEVTVLNEETHCLIGTPRLSRCNEQAKYHDGTSCKLLGRGEATFKFGGTAKRGQFYVSKKGSLNLLGIEMLDAFGLLDDARKKVATALQLNTVKKEASEEKSLTGLKAKFPDVFCTGLGHCTKAKATLTLKADATPVYCRPRPAPYNTKLVVDAELDRLQAMKVIRPVEHSRWAAPIVVVKKANGSTRVCADFSTGLNNALLLHQHPLPIPKDIFATLNGGRIFSQIDLRDAYLQIDLDDSSKEMCTIATHRGNFQYQRLPFGVKSAPGIFQSIMDSMLAGCAFAVAYLDDVIVVSRSPEEHTKHLEMVFARIANFGFRVKAEKCSFFQKQIKYLGFIVDKDGRRPDPAKVQAIAEMPVPTNLSTLRSFLGMVNHYQQFVKNMRFIRQPLDNLLKQESVWEWSKECQEAFEKVIRILQSDRLLTHYDPLKEIIVSADASEHGIGAVISHRFEDGRLRAIAHASHSLSPAQKNYAQIEKEGLALVFAVQKFHKYLFGRHFILQTDHKPLLTIFSNKKGIKPCTANRLQRWAITLLGYDFEIEYQRTLEFGQADALSRLIAKTPTPEDEYIVATIVESADLETLKAVIKHFPVTSEELVKAVEQDQTFQNVMKFIRTQWPNTKEMSKDIVPFHRRRVALSIENRCLMYADRVVIPAALQKEVLQQLHEGHPGIRRMKNLARQYVYWPGMDQQIEDLVRSCTPCASEAKAPVKTLLQSWPKSDGPWKRVHMDYAGPFFGKMYLLFIDSYSKWPEVFEMKSTGSAATIDKLRYLCSRHGLPETLVTDNGTQFTSKEFKEFTTQNGITHLCSAPYNPMSNGQAERFVDTFKRTCRKLKGEEVVNRLDTFLTTYRITPNDSLPEGKSPAEMFLQRKFRTTFDLLRPKRRPIVVRDEEMEKRFNRRHGAKPRSFDVDAKVFARHRLSQPWRAGHIVSRKGVMYEVRFQDGKLGRFHANQLWDRTADDKEEDPLDVFNDAFGLALLPAEDQNLGELADPPMEEAAPIASPAPPVEPNNGAVVPAAPERQQNIALNKTVKEEKVEKRVKSEFMEFDRISDKEEYNNGEHGKEQSTDSYSLLDNSNLKESSSKPQKACRAKGMSCNMEKIAQKLGVSYRTIYNWKNEFGAPKKQKNHTDVEKVELLKKFHKIKKENPQLLKYEIAQMLNIHIKSLNRWERESRGLLEPGIKKIYSEEENVENRVKSEFMEFNRISDKEEFNNGEHGKEQSTDSYSIFDNLKETSSKSKGIKKKYSEVEKQEIIAEFDHLKKEFKIRAKGMSYNMKKFEEKIAQKLGVSYRTIYNWKNEFGAPKKQKNYTDAEKVELLKNFYKIKKENSQLRKDEIAQMLNIHIKSLNRWERKSKGLEPGIKKIYLEAEKQEKVAEFDELKKEFIIRAKGMSYDMKKVDEKIARTFGVSRSTINNWKKKFGVTKTLKNYTNAEKAELMKNFNKIKKENPQLRKEEIAQMLNIHTTTLNRWERESKGLEPEFDQFSKERQQNIAFVKEENVEKRVKSEFMEFDRISDKEEFDNGKDGEEQSTDSLFDNSNLKERSSKSQKGIKKNYSEVEKQEIIAKFDQLKKEFKIRAKGMSYNMNKIEEKISRTFFGVSRSTINNWKKKFGITKTQKKHTDAEKAELLRNFYKIKKENPQLPKDKIAQMLNIHIQTLNYWERKSKGLEPGIKKIYSEVEKQEIIAEFDELKKEFKIRAKGMSYDMKKIDEKIAQKLEVAIRTIYNWKNEFGAPKNRKNYTDAEKVELLKNFYKIKKETPQLHNFEIAQMLNIHIKTLNCWERKSKGFEPGIKKIYSEVEKQEIIAETIYYWKKKFGIKNNCSEVEKQEIIAEFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICJ2</accession>
    <name>A0A914ICJ2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914ICJ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8671.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8671.t1"/>
        <property type="gene ID" value="Gr19_v10_g8671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8671.t1"/>
        </source>
    </evidence>
    <sequence length="445" mass="49910" checksum="DE20090A37CC4F91" modified="2023-02-22" version="1">MEVSGFPHQVGGHFGLLSISGHVCKPYNHREFEFYSQMDARLSTFTAKLCSKIKVQCLNQNVEDGTLLMSTEQTINCHRQSTENASDEPIVCSSTPTIFAAPLTKANGRKKYSMTFRVKSGRVEAEKSLTANHWAGQCQSKIVQKLLKGHDRSFIILEDLVSKYSRPCVIDLKMGTRQYGDDASAQKRLTQTQKCRQSTSSKIGVRLVGMQLFDRDAGEYVFVNKYEGRRMDGTQFHNSLLHFFKVAGKSRTRRLIEELLRLRKVLLKAEGFRFFSSSLLIGFDGEHKNKLDEEDIAVKMIDFAHSTFNGFLDDQPYSGTDEGYLLGMDSLLRILTIFQKNRLVTPMGGVKQGIQLAIGEKKRCGMKRKYSDEDEESRSSISSSMYTSDSCTGEETEDGGGSATPETARTNDDVASNFNNIPLLKMNRCECEEGDEDTETLVAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDH1</accession>
    <name>A0A914IDH1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDH1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8876.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8876.t1"/>
        <property type="gene ID" value="Gr19_v10_g8876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="394"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8876.t1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56204" checksum="54C3D3BE838BD1BC" modified="2023-02-22" version="1">MAKTAAIDVNQGITADKTATIRNYFTQPHLIYKTVTGVRGPLVILSHVKFPQYAEIVKLTLPNGEKRMGQVLEVTKDKAVVQVFEGTSGIDAKNTICEFTGDIMRTPVSEDMLGRIFNGSGTPIDKGPNVLAEDYLDIDGQPINPWSRIYPEEMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNEIAAQIVRQGGLVKHPNKKKENDAEEDNDDFAIVFAAMGVNMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALTCAEFLAYQCQKHVLVVLTDMSYYAEALREVSAAREEVPGRRGFPGYMYTDLARIYERAGRVEGRKGSITQIPILSMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRADHSDVSNQLYACYAIGKDVQAMKAVVGEEALSSDDLLYLEFLTKFEKNFISQGNYENRTVFDSLDIGWQLLRIFPREMLKRIPAKTLDKYYPRGGTGARNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEA9</accession>
    <name>A0A914IEA9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEA9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9102.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9102.t1"/>
        <property type="gene ID" value="Gr19_v10_g9102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9102.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8328" checksum="5B6224BD13D7A347" modified="2023-02-22" version="1">MKAQNIIIIGVIVCLIGTVLLLNNSKAKKQQQSDGHRGIQPCLEECSDKYEKDQITKQQLQLCYHKCVVSGQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF42</accession>
    <name>A0A914IF42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IF42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9332.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9332.t1"/>
        <property type="gene ID" value="Gr19_v10_g9332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF51">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9332.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26962" checksum="D03E1E9B6C8B2308" modified="2023-02-22" version="1">MDGTRAILITFSIAFELLGICFTIYAILSSAWQTANLDNSLHEHGLWLDCIVQNKNRNFNFSESTRCYYKFDFERNYGNFDPEYLATAEVGRHRFFRWQKSVIILLGISLCTAIFGVLNGVLNLLILCFGLCLPRLCALCSLPFTFMFAVTVLVTAIFSLVGESVFYVFAMQPQIRFIGNIQRIEQKLGLAFYVQMCACLMNLLAFIFVLVAIGIFYLHWKQRRSSTQRIFFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFZ4</accession>
    <name>A0A914IFZ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFZ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9892.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9892.t1"/>
        <property type="gene ID" value="Gr19_v10_g9892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097355">
        <property type="term" value="P:protein localization to heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057603">
        <property type="entry name" value="Periphilin-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028851">
        <property type="entry name" value="Pphln1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836">
        <property type="entry name" value="PERIPHILIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836:SF4">
        <property type="entry name" value="PERIPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25234">
        <property type="entry name" value="Periphilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037802670" evidence="3">
        <location>
            <begin position="20"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="55"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9892.t1"/>
        </source>
    </evidence>
    <sequence length="669" mass="73079" checksum="0493BB77CBBCEEF8" modified="2023-02-22" version="1">METLLQLLCLVCSTRHVTRLVVVVLTPRSPTNFDNTVMWRRNDRINERDVPESQHTIFIRGLPGEMGTDQLRDFFEKDFGACSFDFVKVSPDRSKLYVAVRFESKSCARDVMENFGGEGELLGYQVEMSWFRDIRRYLAHCAKQGVRPSRFRGGVGGGGGGGGGGAMAHRRGHQRGAGTGHRAERDVQERSRSSRSRSADANSRTRSPNSRKGTPDSRSSRRTRSAASRSRSRTKSASSVARSSPEREKSSLDYSDIATTKKKEQRELSPSPTPPPVKKPKKSAKKKRHRERAAAAAAVTATPIKKQKQQRELTPPQSSSLSPDRRSDSDVEVASDDDDNTNNDMAVNSTGGSNKQQQQHHHQQQQPAVVALKKNYGASAAATAPATAPSFASRHIPAGTVAASAAAAAAAGGCVGVSAAEALIKTELRNQTIMLDMSDPKAAAHPLHSFKAFGEQQQQPFVDRLLNDCVRVDPVTTAAAALTNNGTNLSPFSSQMRNGTDNNMAGSKMQQQQQQHQNCGGGMAVGGVGGSGGAGLALNNFKEIQRAILLDVRYKPQEASAAADEDSASLGQLRLSSLSRKTLTEDKREEKVAKLSPELRDRVNKKKRQLELSYRNDCETYGLVANKLVAKDRLLEDRLKLALLETMKELEAETMKQLDDFLDQISFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGD7</accession>
    <name>A0A914IGD7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g9637.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9637.t1"/>
        <property type="gene ID" value="Gr19_v10_g9637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
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    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
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    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1617"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="472"/>
        </location>
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        <location>
            <begin position="555"/>
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            <begin position="1944"/>
            <end position="1971"/>
        </location>
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            <begin position="2075"/>
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            <begin position="2686"/>
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            <begin position="2874"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="3501"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3534"/>
            <end position="3558"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="427"/>
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            <begin position="562"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9637.t1"/>
        </source>
    </evidence>
    <sequence length="3558" mass="404983" checksum="265BFF5BD0B302D2" modified="2023-02-22" version="1">MSAPIQQKLGAALKVLSRARPAVDLKLQPDKNLSNLENALLLEAQLEKVQKEGRTLEIFLDDIRESSSAWTDLLRKLAAAERDAGEAAFEAFDRKEKINDKVDDAAVKLRDLRDLAGTLTVQAKLYRSRANKDERDAQAVHDKAVQQNTAAPRSNAPPFAAPLYQFQPIQLEKFGGHKRRWPEFYESYKSAIGSQPISKAEKFNFLRNMLTGEARDLVAGFRLEDSNYDVALQLLKDTYGAPEEHIRALHFELANLKACRTLRDTKEFLLQLERLTRELNNAGEDIEGPPTFLMLEKKLTPGFLRTILTKKAEDPAHWNTNKFRDTLSISVRKETQIQEVMGEYGHPSQFGKTTQPSTQAHQQRARLQPAPAFRSRYRSPPPRERTFISSAVDEANKRFGTKLTQRKPQQTGQQAGLQPYPQKHWPTATTQRKPQHTGQRADQQPPQHQNGQAARPFQSANPQGSGGFKRSEPPSPCIFCGSGHWNEECRKFSTLQQRTAVIREKRLCFKCLKSTHRSFDCPKPKRCFRCGQPHPAALCPNGNSGSMQIAAATIGPNEDENGSPSTAGIGTESEPQQSTVVRDNEKKALLMTTTSTVFNPAQPQLSMAAAIFLDPGSHRSFISNRAAQQLDLPVVHREECHLTSFGERKPKKYVSDRVKIGILGTAGEKLIFNLNALGFMVSEMPIIELSGLDTSQLQQRKLALPHETTQPDILLGINIWHELNVQPIERLPSGFTLCQSKIGKILSGSGRIALGGPSVNVTFVLPVQNEAEEEPDQAAKTEPISDDNEIFTTEDDLKRDDQLNRFFGLHIIGMDDTSTKMDQDAVMIDFKKTLSFVENRYQVALPWTERVNNLPTNYLQAKMRLISLVRKLRTLNLVAEYQTILTDQLQKSVIERVDMSSPNIGPVHYLPHRAVIRTDKATTKIRIVMDASAKPKNNPAAPSLNDCLHTGPLLLKDLTGVLIRFRRMKRVLMADIEKAFLQLGVRQQDRDATRFLWLANPATDKLDPLRREDVLVYRFCRVSFGLTVSPFLLNATIREHLAMYDSDLARRIDENLYVDNILIEVKNEEELPALVCEAKAIFATAGMVLREFFGSDLEEVKKLPPADLANELEEAKVLGISWRPKHNRLLFKMPTFDGKITKRTILAHIAKVFDPLGLMAPALLPAKVFLQSVQNFNPKWDDELPEHFNDAWRKIVALWTIRGEPFVIEFPRFITSTECDQFHCFCDASRYGMGIAVYQKAKTDNGNEECNLIYGKSLVKPLKLGEHDSTIPKLELQALTLGVKAVKFIQGQLHFKDDQVLLWTDSQCSIERLKENRKQDRFVSNRLKKIREANFQVRHVRTDSNPADLASRGTDPQLLVSSLLWRFGPIWLAKSGQWPEPNATYNPGEEIKEVVEPPIIDLSMAIHEAQAKALRPSIQVKRFSNWNRLKATAAYALRFIMTLILATKFEARNYPLYRLSRDDAVKNLRKKPTTGPLTPNELERAEEWLLKEMQLAYLPTRTLIRDLRLFHGNGVWRCGGRIGQADQLDYEIKFPVYLPPESWLTKLIVRNYDNALHHCGPKTLLSKIREKYWIPRGRKTVKHILYSPDYGCLECRRDRLRPYAYPRAPHLPKERVNEARPFSQTGVDYFGPLKVRRGTDTVKIYVALFTCLVIRAIHLEVAEDYSAEAFLRAFRRFVARRGTPTLIRSDQGTNFVAGAKVIKEKWTDTLLPARVQQQLAHQGVNWFFNTAKAPWKGGSWERLVGITKNALRRSVGRNLLTMDEFSTLISEIEAIVNQRPLTFESDEEPGSILRPVHFLIPYGQAETNFPLIAEDHNDPDYNPSNRDKLHAMLRHADSRLDKFWHVWKSDYLLSLRERDRGTAEIDQQHPTEGDVVIVQDDHQPRSLWTLARVLQVQKGGDGAARTALIKINGKEKSRSINQLFNLEIGTSFPVEQVNSIMDRDPDSISLAGSDEERDMDQSGPSKSGYKIPRKTDIVFKKQRHFLGRNLGLNEVQQKPSDYDPAMGLLYAPRPKGKKLFFKNGSLKRLLELTTVFSRGKGVQIAKELLDQHGKIPMKDWAAKEQQITAELLEQEEKRQEKSKERKQQIPEQSETEQQMFQRLFGDSPGQIPEQTTDNEAKDKESRLQQNEKRIKWHHHRKAAVDELRRKMKLRKRQQAPASIEEDIDDPGKEDQQHLQKLIKDGSQEAQRAFEASNQLTLRQQSQQPLHHKPQRHASDLPTNGEKLIDFCKRLYGDHLESAWKRQRAFKEMQEILESGNFKLYHVNGQQASIKCFLANRHGLGGLFIINKIESFNHPDEFEFRTAPAASKGAIERPESPEILIITAPEQNAPRPTTRFAGRTPPPGHTPPPFQEWLKERNQEQRRPPIQNKPLRIEEYQLAAHKEETFVPVDIFLECGPDHTACAKSAIYSEIAGQRKVVEGYEACTAISLFHAMILHWLHRYQPNPYEAWQLHEDYAVLDGSIQREAAEHFWRHQVVNQKRPLFKPATLIATIGHWRQSCDHFAELFQTPSMAPIRFQPINRTQTANPFQNWLEEINTHASDKTSQMKAKLHFPQSRYLNNAETIVIGETIAEAFSHGMPQAFWFSHTVTDPLRVFFGPKIRRLVFAYDADIKNIVKYLAPIIHPLSKTDVEMNIILGKEDNLDWLENKKHVLSLAQLFKIGFFVFNGKPGEISAISERIQGQQVEDMEVDSTPSTSTAPSSSRSSKSGSRDIINTAMLIGLFCLLAIQPTGGQAIRQKRFGGVGIWPGNDFLNFLWSRERRTPALTTAGERYVEKVRAFYATSNPPITFADLTTQPSWTTTQAPITDPPTTQTVQKSQPTGTTTRPTTTTRKKWIQTTQTIPTTTRQKWIQTTQTIPTSTRRKWIQTTQTIPTTTRSPSWTTTRPMPSPTYHRARPTVQPAATPTKSYYALPLKREQPAESANPTPSDRRIINANGDNIFWCTDRGSSIWELKGTDSSPFCRPPPSLNAEWHPLQVDLYVRITKPEEIASAWHCAIKRTTETYYTNLFGDHFVDIEKEFAVNERTCALMARQQVCSAAKTEMLHQGDQVWTTSDTTEVEFSGAFAGLFKGRQSSSATNCFAQPAALYVKRHNLELVSPIHQVRNCIYSTATAVTDYEMAEGIDGDFTPSYGETAATWLSKDRQKALTFAANAPELLACDGAHIVLSEQNFGIPKKLYDDILSTQHAKKKRHVQPEQLAAQLSASQIATNMALAQLYMRECQRNIRAANPTLQARKLLRRQNLQARWIGESTIEVFQCVDIKLTDISYRPTKTCMRYIPITVHLPESTMDAFLDPELRVISFGATAVSCTHFRFHYLQLHASPSTWLQIDTHTGVARRLESNVVHDLYETVLNHSNNDMDLHPLIFHRWQLDNETDSTRFPHISEFAELENFKDKLDQHSSARAEALGALTGGLEGWTKQWLKGILNSVVEWWIRMACAYSTFLLLRDIVIPCILTYLFDPIRITVLSLLGVRRPRQPPIENEMTRLPRFHMEEDILLHNPRRAPNPTTRREEGAKQPVHLDVSAKTAHFRQRTQSNTEWTGDTPFGRTRRLALDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ62</accession>
    <name>A0A914GQ62_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transcriptional regulator ATRX</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g10403.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10403.t2"/>
        <property type="gene ID" value="Gr19_v10_g10403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="642"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1078"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10403.t2"/>
        </source>
    </evidence>
    <sequence length="1545" mass="176369" checksum="56B64C715128F4B5" modified="2023-02-22" version="1">MAESAKLAKSFGKRKLAVECSFESKDKLVLHDIHSEKSVELCACCSKLVVNDLMMDETDGVNESLVEYSHGGPSLDPAKEGPIRDNSEGFLPVDDVPNEDNELPKEDDALNNRKQRPKETARGLNTADGEAENGVQLAAMDVGRSPSEVNGTSCREEEAKRQFGITSAIEIPVSLQNFNRIVQKIVGGQQKLRISNSIDDLERQSRSGKRLLSQLNRIKMRKLADGQGEKCTDERNDENSANEQNETEESDESDKDQPQTSDHVTKRRERKRKAGSKKSATDKKKVGGDEKMEQDDEWLSKDSANRRTSSDHIDSLPCDDKKSADKLSDGGSESDSTASDGIPPPKMTRAQHQKNLELKKLFRQANRAMIDDDDDDQPPDEQSDRNSDMSYTEKEPKSNSKQRNNAAILCSSSSEIVIDSDDDDESIKIGCSDDDDDDDDFGCRRKRPNRRKSTSGGYDVLTLGDGPSTSKNKQKTKTKKQKKPVKKRRPGRKNRHMASDDESDDKNGSEADNSGDLAEIVPSSDEEVPKTTSSKKVISKKDLTVETKEAERAEKERRKRLEERQREFNGIELVVDANTDSTIMVYKGEGSRPVLKSIVLDPDRGNDNPDPVKVHPSLVRVLKRHQADGLKFLYNCTIESLSRLDEQGGGAILGHCMGLGKTLQIIAFLHTILSHPQISEKIHKVLVFAPKNVLLNWVNEFDKWLFDNDPELDGVLTYSEIDSQTENSDRLLAIKRWANCKGPSVLIIGYDMFRRLTESDEDKPVPKRGVKVRTQKAKHKTKKEMALDKLKPQFRKFLFEAPHMIVCDEGHKLKNCDSVISKTINRISAVRRICLTGTPLQNNLGEYYCMVNFVKPNLLGNIKEFKSRFEHIINRGRTVDATKQDVAHMKRRCHVLHDRLRDILDRRDYTVLKESLPPKQEYVLMIRLTQPQIELYQHFLEFAESQQTLNGKYLLPNHVILYRIWTHPYLIIEHEREEERKQLMIDDGFVVPDDEDWDENDDDEQDVEDKDEDDDEVQEVHDSERPSSSAKPTRRSRRQNGETVEERSETPIELKEWAKNHVTEKDRERFELSNKLILLVEILKKCEAIGDKLLVFSQFLNSIALIQRMLAYYAERDQWFVDGHDALMRQGEQWSWKMGLDYDVINGAVSSKDRDRIQHEFNNPMNLRKRLLVISTRAGSLGINLVGANRVVIFDCCWNPSHDTQSLFRVYRFGQEKPVYIYRFVAQGTMEERIYNRQVTKESTARRVTEAAQIQRHYKVEDLELMYRFEPEPLGDEANSQRPNLDPPKDRLLGDIILSGSKAITSYHTHDLLLTSIEEEQLTSEERDEAWKEYENETQPRQQIPLVPPTSVANGTALPGTQSFGTTDMTHFTNALQLRQLQLLQNMHKQQQQQTTAGAAQNLANLVQQSTQMGELGYFTRVMVQLMSAYSNDPVYRLCFKVPGMQPKTAYRIFQIKQFLSYFVNLIPTEDLGEMNNSNAFSLYFNGILQKAIQEKESQQNVEQKAMITLATTIEIAKPHQRCQAGIAFIMQTFPEVAQHLDRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRX9</accession>
    <name>A0A914GRX9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GRX9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1084.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1084.t1"/>
        <property type="gene ID" value="Gr19_v10_g1084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF57">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="63"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="9">
        <location>
            <begin position="262"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1084.t1"/>
        </source>
    </evidence>
    <sequence length="440" mass="51017" checksum="EF844B075703406F" modified="2023-02-22" version="1">MYLRKANTKKEERWYDRHGDPSKMCHRNATTNGTDQQTTRASSPGPFGSRTCDPPLALINFMLKEAQKKLPDPDYIIWTGDNAAHDKYDESRLLSTLESANSAILQHFPGIIVVPVVGNHESVPGNDFADDEGNNNYAGIFERWKDWIGESAKKTFLRGGYYLFRSPLDNSTFIILNTNFYYVGNKEVKRNNSFAHIIAHIPIGAYEMYSVKNEDWKPEMSRRYNRRLYEIFVAYSPWIRWMLFGHLHTDTFRILKAPDGTPVQRMFLNPAVTPLFNLNNPAFRIFEYNPKNMDIDDVKTFYVELEALNENGAEMTEAKLEYSHREAYQIDGPLSAETLNKLLERMKQNETVFDQYFNYSSVQWMTRKLNETERASHLCVLEYVDYDQLAQCIRHNQKNAITLLYVAILTALVLAVAISLVAVFLICCYFRKNVGKMRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS18</accession>
    <name>A0A914GS18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1024.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1024.t1"/>
        <property type="gene ID" value="Gr19_v10_g1024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1024.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11125" checksum="8E971505E57A9388" modified="2023-02-22" version="1">MGPGFPLFSVPLKIPLGQRVLFSRESFSPTELYQKLKLSLPQFCVMIREWILLNATHMEARLHMATVHPNCGKSPRCATYHMLLHTQIVYKRVYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS79</accession>
    <name>A0A914GS79_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914GS79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10809.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10809.t1"/>
        <property type="gene ID" value="Gr19_v10_g10809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10809.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43133" checksum="6260E28A35A95B82" modified="2023-02-22" version="1">MTILKHVWLDTSTTIVRIVLDQGIGFYHKDLLIERVADDAKQCKPEGNADQLQFGHHYSDHMMDVDWTAREGWGRPLICPLREIKLHPGAKVLHYAVEIYEGMKAFRGVDDRIRLFRPEMNMSRMKKSATRAAMPNFDSEELLKLITELVRLDRDWVPTKAPASLYIRPSLIGTDPVSPVESPRSVKLFVLTGPVGMYFPVTQPVSLYADPSVVRAFPGGVGGYKMGCNYAPTIAVGELASEHGCQQVLWLFGKDELLTEVGAMNIFIYWKNELGEMELVTPPLDDGLIMPGVSRDSVLTLAREWDEFRVSERYPTMRELRKAIDEQRLFQIFGSGTACAVSPVGRILYRSPGTGQMDELLIPTISSGANYGKVIRADWTRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTN7</accession>
    <name>A0A914GTN7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTN7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11248.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11248.t1"/>
        <property type="gene ID" value="Gr19_v10_g11248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11248.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10096" checksum="52AD00DC3877CBD2" modified="2023-02-22" version="1">MSWVVDELGVDELGIDELGVDEMDDNSQHFIWWHDFANGLFVNDFSSLNYSSTTFRQWTIRQRLFVNGLFVDDISSMDYSSTTFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUC6</accession>
    <name>A0A914GUC6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Lipid-anchor</topology>
            <orientation evidence="2 13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUC6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11280.t3">
        <property type="protein sequence ID" value="Gr19_v10_g11280.t3"/>
        <property type="gene ID" value="Gr19_v10_g11280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000004">
        <property type="entry name" value="Phosphorylase b kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF7">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="11 13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="14">
        <location>
            <begin position="28"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11280.t3"/>
        </source>
    </evidence>
    <sequence length="497" mass="56359" checksum="34603E7F571ABC7C" modified="2023-02-22" version="1">MKCRVQAESDTEVNDPLSGEMRARSQSGVRLDQLMVVVQKTILLSQDPVTGLFVSNPERYPSHAWIRDNVYAVQAVWAMHRAYQKRAEFDEDLVKAHELGLNCVKCMQSLLECMLRQADKVELFKRHQRKSDCLHAKYSAKNKATVIGDNDWGHLQIDAVSIYLLILAQMTASGLQIVRNFDEVAFVQNLVYYIETGYRTPDFGTWERGDKTNQGIRELNASSIGMAKAALQAINDVGDLFGDGSKGSIIHVLPDEIQQCSAVLCNMLPRESFSKETDAALLSIISFPAFAVDDSSLATLTRETILATLGGRYGCKRFLRDGYKTALEDSTRLHYINCELQKFENIECEWPLFLCNLYIDAVYRKDETAVNALWKQLQTIMIPDSRESRLNFVQLVPELFKVPADKVDMERLKHGSQNRIPGGTIPFLWAQSLYVLCCLLHDRYLTPAELDPLSRRLLATEKRPPCEVQVVVLAEDRTVKEELTQNDIDVQMSRPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW07</accession>
    <name>A0A914GW07_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW07"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11854.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11854.t1"/>
        <property type="gene ID" value="Gr19_v10_g11854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11854.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14615" checksum="BD06D6F5B50366E4" modified="2023-02-22" version="1">MYTFCAWCVQNVCNEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEQTEELLNAEKAVTRPRPGHDNKCPPLFGAKPKRASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW79</accession>
    <name>A0A914GW79_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GW79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11761.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11761.t1"/>
        <property type="gene ID" value="Gr19_v10_g11761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF8">
        <property type="entry name" value="PROTEIN TWEETY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="473"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11761.t1"/>
        </source>
    </evidence>
    <sequence length="597" mass="67018" checksum="C1B61B82BFD325DB" modified="2023-02-22" version="1">MGEQQRTNFADWLLKWVHRVPHFDFRFRRLQRETPFDVDPNGEYAQSLVILCALSLLLALLFLLATLLWWVSQCCVARRSSTPNRTSSKRVGRLSCALFLVSVLCFALMGACLYGNEHVNKSVRESAGALAHIANAFRLAMEKTRKLNESQRAKTSINQTALIREADSLLTELSDNVDELKQRLGRTLAILVDTQFLEAAKRKGERVELERSLLCLLLQVIMIAVLFAGVTAFCRQSRKGAIIFSGLGLVIFLVAWLLFSAAFPLTVAFADFCMDGRPFLRTHLNDELIDVVQFYADCTPLQADLHTNSEAAQSVPGALPLAIIRQLTAEQNAAEHKLEALLARLFNGSVEIESVTAQISKQIMTTARLDGAVHSALQCSALHQDVLGMQHGFCRHAFFGVALISFTLLLLGLSLFVLLILVSKSWYIFTRLPNDYLEVGEDDQFSPRCHDAMPDNIYDTNIFNPRARQHLANTSAAAEGTAQNSAPNGAAGGSVQLRNSPDGNGMAQQAPSWQQQLLRAQRRACHGACGHVTARHTYEKWRRHSHLRRQLSADQRRRRRQPQKFNKNCFNKFKQFISTIGSSTTLFRFKFFMFFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWY0</accession>
    <name>A0A914GWY0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWY0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12108.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12108.t1"/>
        <property type="gene ID" value="Gr19_v10_g12108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF90">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="330"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12108.t1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56196" checksum="3407AAB525C076FB" modified="2023-02-22" version="1">MMARKHSQHHKRQRGKSPSSFQLLEGADGVEAEAEDDATPNGEEDRKRKVQLTETPWGQRLIGGGGGGAEDKENDEEEEEEEEKEGDEAEGKEEEEEEEKMPMWKKYARIVLPHIGLILLSLCYIVGGAFVFYQLERPNEIAVRRETLGVIEREKREMLEQIWELLNDPTVPRDRVESVAAERVENMTRLMFDAFDTHYVGLAHLRGTKSVDQSSWSMTTAVFFTSTLLTTIGYGNLVPVTSAGRMFCIFYALFGVPLILITVADIGKFFSTLIVLLYTHYTRAKLRLRGRLLGGAGGEDAAGHPTLMRAHLHQLGLYNISIPVTLIAAILLGYMSIGAVLLASWERWALFDGFYYSFITMTTVGFGDIVPAKHEFFLFDLFYIIVGLAITTMCIDLVGIEYIEKIHYFGRAISGARFALVNVGGKMKYGQRKSPKQQQKSGTSTHRHFVAWRGAYEPTDLAYIRFIDFGSLASFESISSFFSEIFTNGGSRKSREPSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX35</accession>
    <name>A0A914GX35_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Alkylglycerone-phosphate synthase</fullName>
            <shortName evidence="10">Alkyl-DHAP synthase</shortName>
            <ecNumber evidence="3 10">2.5.1.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57534"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:73315"/>
            <dbReference type="EC" id="2.5.1.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Glycerolipid metabolism; ether lipid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.26" evidence="3 10"/>
    <dbReference type="AlphaFoldDB" id="A0A914GX35"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12148.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12148.t1"/>
        <property type="gene ID" value="Gr19_v10_g12148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008609">
        <property type="term" value="F:alkylglycerone-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025650">
        <property type="entry name" value="Alkyl-DHAP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568:SF1">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="146"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="247"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="260"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="312"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12148.t1"/>
        </source>
    </evidence>
    <sequence length="613" mass="68462" checksum="2140F5A2392F7A9B" modified="2023-02-22" version="1">MQSLQQQTQNAAAESAEEEEEFNVPDNVFRDSQLKWNGWGYEHSAFVLSPDGQIVMHSDEYVDLDGKPLPALRPWIEQHLGVDLSHRTPSVSAQSLHIPPTVACAEQFLRFLRSRGIPFSNVGMRRVVRSHGQTLAEVLSLRMGQIGRIVDLVVWPRSEAEVEEIVRSADSHGVALIPIGGGTSVSNALNCPQHVDRCVCSVDMALMDQVLSIDTDNHCCTSEAGILGQVLERKLNERGFTCGHEPDSMEFSTLGGWISTRASGMKKNKYGNIEDLLLQVTLCTPKGTFQRLGQVPRLSAGPDLNQLVLGSEGTLGVIVRATIKIFPVPDIRRFDSILFPDFEAGICFMRQVASLKCQPASLRLVDNQQFQMGQAMRVQSPSLWHSLEHRLARIYVTRWRGFRIDQMVAVTCVFEGTADEVERQQKRLVNVAEQFGGMGAGEENGRYGYRLTFAIAYLRDMAMDHAVIGESFETSVPWSRVSDVCRNVRILLVHEARRHGIKYPVLATCRVTQVYDAGACVYFYFAFNCRGMESDPMHVYEQIETAARNEIIACGGSISHHHGVGKIRKKWLPVTIGPLGISVLEALKRELDPNNVFENGNLVDLQREERSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX85</accession>
    <name>A0A914GX85_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GX85"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11596.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11596.t1"/>
        <property type="gene ID" value="Gr19_v10_g11596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000173">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11596.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13871" checksum="A27D0CD0E18ACC07" modified="2023-02-22" version="1">MSGRNKRVKAKKGGHSRSSRAEVIFPVGRIHRLLRKGKFADRVGAIAPVYLAAVLEYLVAEVVELAGKTAQDNNKKRVNPRHLQLAIRNDEELSTLFSGVIISQGGVLPHIQAEVLPKRVFNKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYR0</accession>
    <name>A0A914GYR0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYR0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11629.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11629.t1"/>
        <property type="gene ID" value="Gr19_v10_g11629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11629.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15576" checksum="48D198E7426614F2" modified="2023-02-22" version="1">MRKKRKRKEKRKKMKMAMDSTKEEGSGSTKQLHALQSFARDNSPFARDVAFLPTLENPKFRRGAITLETILELHKGVMEADGQNEAAGQLRTCNVSVGKHRPIDHSQVEAKMLTFVHWLDETIVLGEKGARAQHRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYV7</accession>
    <name>A0A914GYV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11668.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11668.t1"/>
        <property type="gene ID" value="Gr19_v10_g11668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037344250" evidence="1">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11668.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27396" checksum="ACEED4DA05B8A893" modified="2023-02-22" version="1">MNPIFCFFVLTTLVGIEGQLKNVQPQKEDLIKDMKLAIEQAVKAAAKQLPKVFVEVNDVGNCQKTVKADCPCGRAKCVRRTDHSCSNELTKCCPINYALECCGTGKKCFDDCVAQALPYDEKPDPKERQIICASHCLQACDHCTKAGTKNNIFKTALWNCLEECSDKLLKSKIFYWEIERTPRGKGIFPIMGKMNKRPAGFHNVEEFVTDSGIELVLLERMFNFEIITDSNKKSGILAGGTEVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H077</accession>
    <name>A0A914H077_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H077"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1242.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1242.t1"/>
        <property type="gene ID" value="Gr19_v10_g1242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038100076" evidence="1">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1242.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19922" checksum="D5B37D67B3296889" modified="2023-02-22" version="1">MPIVTSFVHLTLLVLFVMECFPLGTDGGNANSRAEQIPEPPFFPSRHKRQSFSRYICGIPPFIFHSDIPCSYWAICVNHGFATNLPCSDNQSCLERNPNTECVQGTCCTLPSVQMPTTIPDTLQLSTNPSTFPTSKCSISTSYRIVRPLTDNRPISLGPRGLPTETRLKLFLTWRQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0R3</accession>
    <name>A0A914H0R3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0R3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12171.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12171.t1"/>
        <property type="gene ID" value="Gr19_v10_g12171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12171.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35009" checksum="4055295213408F34" modified="2023-02-22" version="1">MLKGMQRRRGGGQLSMLGGADMEGKESFVSSPPVPKRRNFHFSAEEYSLHKFWSNMASNIVGQRRNGGAAAGGGETPEGVPQKSDTLSIAAAPPAVIVVANGQIEVNTKTLIAAAAAVNGVNGGEKVVMNGRATEAADRSPVNQRLGRGQSAPKLLLDGSQNGLLTTLCEENGAGGGDGTEKEARRKDEGKENGDAGILETMKAKMMTMKTNNNNNNNTSNSSRNRNNTLPPLPLTNGLRHRVHRSQSPSLFGSTKKRCGPKLDTKERLFGQILPETPKKKLNDTYRSTIFSDTVPNSPAKTPKKCVPVLERNPITGEVKLPKKITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0X7</accession>
    <name>A0A914H0X7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0X7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13144.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13144.t2"/>
        <property type="gene ID" value="Gr19_v10_g13144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF34">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13144.t2"/>
        </source>
    </evidence>
    <sequence length="334" mass="38080" checksum="5D7F011E70363A31" modified="2023-02-22" version="1">MDPNELTQNYVRKAYADIKRRVDEEAETAKRGTGGGFSSIARSFPFVLGHLRQIAPHSLILDIDSFTIGMDVNGAPRGKAENVDFVLADASYPPFRKGLFDAVLLVSVLHHIPNEEIRAKCLRNCLWLASAEKCRVVAVVWAKEQKAAEFSSNDVLVPYNLEDMHKLGHTVEIPFNKETTREQRIMLNAVPIRVKVPPNIRCPNYLPKNVRRRVLEVEEEAKAGRCLQTKDFSPKNISARDPRGSICEFSLKVSISVLDDAFAQLRKIYRDVLKYRYYHLFSADELERLMAKIRTTDPFGDFQPIEVEYELGNWCAAVQRCDDPKKTDERTLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H156</accession>
    <name>A0A914H156_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H156"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12679.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12679.t1"/>
        <property type="gene ID" value="Gr19_v10_g12679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12679.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8183" checksum="51C65A55C608D554" modified="2023-02-22" version="1">MWKASFLIFNNPTITDHFSKNFWNTRDTISGSFGLHVNVINKSGLPVSFTMAIASMKCSCILLGPPVKKSSTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H183</accession>
    <name>A0A914H183_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H183"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12703.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12703.t1"/>
        <property type="gene ID" value="Gr19_v10_g12703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12703.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39125" checksum="893421C359AA56C4" modified="2023-02-22" version="1">MGCILVFIYVDDVSGLNGDNAICALTRAFACCCLEHIDLNADALILSEAFLQSDQKLLCEILDRDELMISEEITIWNAALRWADEKCRQNGKEPSAANRRAMLGPALFKIRFPLISQEDFENIVPSGVLTDAELVSILQHYSRPDRALPKPYQLKFPTNGRAGTNSEVVWCWNGTVDDDKQAFIQLKCKLLFVALRWGRKFAAVPKQRLSTLSKLWEMKLPFDEFGQTACKALNGTISRKLCDGNWCNAEQGQTEPGHTEPGHTEPGHTEPGHTEPGHTEPGHTEPTEPGHTESGHTEPGHTEPTEPGHTESGHTEPESGHTEPGQHRVRNGVFVAVPSPTLSTIVVFLLLMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H231</accession>
    <name>A0A914H231_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S phase cyclin A-associated protein in the endoplasmic reticulum N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H231"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13285.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13285.t1"/>
        <property type="gene ID" value="Gr19_v10_g13285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032446">
        <property type="entry name" value="SCAPER_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16501">
        <property type="entry name" value="SCAPER_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S phase cyclin A-associated protein in the endoplasmic reticulum N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13285.t1"/>
        </source>
    </evidence>
    <sequence length="663" mass="77287" checksum="FA36CFEF9FE66AD7" modified="2023-02-22" version="1">MYEICRKQQNFLGCEEAIMFLKNGIRDFLSLIDTIKIEQNWENSEKRPMAPVAWEIRGSISKNNLAPQARNVKEVECQTKFDEDCRANQKEKKEESEWQLVQRKKGAGRSGKNQQNEVNICPFLPVGKQRKAPKSAMDLPQTKASMAKMAYSRQLLFEKHKKTLLEKFNARKRTENREAQSKGKGTAGEPAKTKSSTDLNQIILAEEERKDLEKDGQIVGCLKTLIDRLSDDCEWRAMTEEEESLAQEEESLKKEIEEEEENLPHFVDELVDKDNLKKDDGTVARKGQNEYNNGRVGPINGAEGSSHFRNPGELAQLRAKLLSPTKRRRVEDIDHSSESKLRRAEELRRLLKQEKAQRLNLLHRRVGEERIQKAEEKRQKSLQEIVLKAQEDEMKIIETNLLNSFEAANQRLGKRFTQIRERNRFEKVVLKAEEERQKRIEDNRQQREEAEKRRKHAEEQRAKRLKAQANQGIERQFYAQKHRVKTMEKYRAKLAQHSQKVCQRKESELADKQKLLDKIQRKHEKRTENYEQCKEQSLLGTNQRPINLERVTAAEHGQGEEGVTQTQAMTTSKSCFRCGTKAIFFNDLQLLSHIMSEAHLAKADRKFGSILQSSMFSFDFLKNELEKMTNSDELTEVMTKSTDECSLGRNHETFDDRRDQREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H284</accession>
    <name>A0A914H284_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H284"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12997.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12997.t1"/>
        <property type="gene ID" value="Gr19_v10_g12997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12997.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="8950" checksum="5FF38742B4754355" modified="2023-02-22" version="1">MPTVVPPPVVPKLSSSIGTGDTKFGQNRVVTGGHPEKARMPRGKHKNISIPPPAQGHIGVAGGRRMLSPSSVAEDPVRAVRVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2U2</accession>
    <name>A0A914H2U2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2U2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13472.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13472.t1"/>
        <property type="gene ID" value="Gr19_v10_g13472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="752"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="971"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13472.t1"/>
        </source>
    </evidence>
    <sequence length="1128" mass="127722" checksum="FD9AF670C8DCEA8D" modified="2023-02-22" version="1">MDGLQPHPNPIALPERLPLALPTQPIPSPSFCLPHTLQFLHHHKIHPLSPLSSSLTSSVQHTNVSHHSHQQAAICPSIPTSHSFILPSIPSIQKQNAPFFQFISMRINVPCCQGQGVLTPHMVQMQQRLMGNRPQRTGSAFFGSGEVEMTNSAMDLNDQYQMGMSQRNFGTFGQQNHMMTGFSNRPTAADMGNFPVMMGQNCSVGQVGIGAGGSATANGGFIGSLGTRMSIFKCPECGIVKNSNEELEIHIKTEHLGWLPFQCPICTALRASDLQMREHIHSHHKKNENKYIYVDNPHAKGLLQEMIDRALFGASQYVQQMARRGGGALGGQFGSAQHQAKRPRMDTQNTGSDRRINSAVKRVVDEVTLSRNQAQKRKTAEGVGVRGVPLSSRNRAKVKSEFDMAAGCSPDTLVVPDEDEDNLPDDNSHQMNALQNVSAMFSASGGSNSHAMGSGGVHNLRNSAIGGQQQLVQNASFYRRVVRNRPGPMTSKKRVLGLCRDCEKPITAGARQMHMFYHLGKDANTYRFRCKHTGCKVQHYRKDQMENHQSKAHGKVDTEMMEDRSMELYNLVQQMSQKLLGTTGNTPGPSAPEAQLIYEQQMREMEANLGVRKRRRPEYFGNNLPSNNTVSRSSGLPIYDSANRRVEDLECRLCNKFILNRIKGFHILWHLNTDLGIVRYGCKYCNFKHDRPQSVAAHGIREHSDEAACEDLLYNFEDELKSMSKACFGVERLFEKEIRRRNRLERFARCSTANSPGGRVEDDDNSQHGSNDTKQSQQLTRRRSQQHIMNLKVPLKSESAADRDWTPKEPVRKRRSGARRFFGSRGRKPMSRKARDVMVKLREVSMRLGGAQYFKKRSNEAIPCEKCGKLVINRLSDHAYSHMEHCDLFRCQQCELGHYSRETIVRHLKDFHNSHEAPMDNRLRFAQEIKDSIRECYPRLFIDAPIPTKEDIEKLRESLNLSDQVLVCEKDEDEEGEHVEDEDGELFKDQTNEDGEGNEEKELEDDAEQQSAVNDEEEGEVICEEEEDEDGQLADEDEEEEVVAERGKKEEESGKYEEEEYYEEEDDDEEEEEEEEGEDDVGDDDYEEEYIPPEEQRARSSAKQQRKNDDGNDGEHQRLKRGRGAGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4U7</accession>
    <name>A0A914H4U7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="AlphaFoldDB" id="A0A914H4U7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13252.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13252.t2"/>
        <property type="gene ID" value="Gr19_v10_g13252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF210">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="170"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="317"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="648"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="355"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="700"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13252.t2"/>
        </source>
    </evidence>
    <sequence length="792" mass="87762" checksum="77FCF1C23367BC77" modified="2023-02-22" version="1">MGANVRVVQTTSDANGGSANGGVETVLTTAATPSTAHSKEQLQQQSGQSSKKSSTHSHHQQVADGVATLAKFANFSLAKRFLQQKLAGGECKASADFVEGENTTETTNSMETIPFSPVAGQHFSVASVKADNRPWSNSVNGRIEGTESSDSGKQSAMTKRSSISYHFIFIDLLPKVPSLSPPLNGANGDIGNSAEGDEDLRNELEEEFPLEDGVFVLKDSTFDSFIAKNPTALVEFYAPWCGHCKQLAPEYAKAAAELAQTVPLAKVDAAVETQLAERFKVQGYPTIKLWKEGQTEPTDFDGERDAQGIVHWLKIRIDPNYKPPPEEVLTLTLETFDDFVGDKPIVLVEFYAPWCGHCKQLAPEYEKAAKRLKTHGIPLAKVDATEEKKLSEAYAVQGFPTLKIFRNGRRFDYNGPREAEGIVSYMLNQAKPAANRLNSVKEAHKFMSSSDVTIIGFFPSESGALYEAFVDAAERTRDDFLVGYALDSSIAQHFDTKIDGGRVILFQPEIFHSEYEPKRRIFPKATATGEELSLPSSSIGKSGQETVQKNSQVAVYYNVDFSLAYRDGTQYWRKKVLGIANKYKKQKYHFAVADEEEFSQELNSVGLGTSGLEQNVIVFGVDGKKYPMDPEKYDENLEDNLVSFLKDIGQGKMKPFVKSQSVPKDDKNGSPVRTLVAENFAKIVNDEANDVLIEFYAPWCGHCNSFEPKYKQFAAKHNREERNLIVAKFDATENDVPEKYAVEGFPTIYFAPSGKKDKPIKYSGNRDLEDLTKFVKKHAVASFGKKNEREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H542</accession>
    <name>A0A914H542_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H542"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13910.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13910.t1"/>
        <property type="gene ID" value="Gr19_v10_g13910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13910.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23004" checksum="012487988B023D87" modified="2023-02-22" version="1">MLNCSSYFLAMFISSIAMLSRREGVEGIFYRNIPFQYKTAANVERPKSIADIGGGTNNDDQIATKGEGGNGIRALLNEIEAEDSRQLLADGDGSAGRSRTSFPRRTARLIPLLPSGGSINTNTDQQQPLESEMEQLQPKFVQQGQKSSSPSSSSASSLQSLIALRPDYAFKNVADFLRNFFDSRIERSRKNVAGDGRTAADWRAARSMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5L8</accession>
    <name>A0A914H5L8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5L8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14043.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14043.t1"/>
        <property type="gene ID" value="Gr19_v10_g14043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037157207" evidence="2">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14043.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7150" checksum="C314FC2F6FF47BF6" modified="2023-02-22" version="1">MQFFIQFIVLLILGVALCSGCGGGDGKKENKSNSGGGHRPSASGGTAGGTNLGTTSGLINGGMPTGTRRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H653</accession>
    <name>A0A914H653_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H653"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14036.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14036.t1"/>
        <property type="gene ID" value="Gr19_v10_g14036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037640444" evidence="1">
        <location>
            <begin position="28"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14036.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36560" checksum="A1F1041FDC37034B" modified="2023-02-22" version="1">MIDLYFFHSAKMAILFILILSSANLEAQRNENDKFFDLMTTIGEHFGGEFNDAEKALEALVHGKNSDGTLKARQENPQDKIQTFLAVPKCFPESKLSIFDYWIEIIKMKTEESKNPIFGVAIYKEKYDIYKSEYSKERAFKLSRENYKILKQLNDQKFSIYESTNLLRVAFNWGLMKMMSDKGIDPGLHLDSQDKAIRKYVQNDIEESCKKFDNEEAKIIFLNNIHYELAINFEFNQRKDVHDRARDLLSVWFDGCGLSIYGIIPLSGESYVKKNASEMFQSTKATACCWWNAGGKTIHQRGLLNDGLPTGKKGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6P5</accession>
    <name>A0A914H6P5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6P5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14314.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14314.t1"/>
        <property type="gene ID" value="Gr19_v10_g14314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14314.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20580" checksum="763933102D9F2DFE" modified="2023-02-22" version="1">MVASDVFVAMFRLDEENAKSAAVGTVKEVKPVEVETGAFKVMLSFIYADDLSGLNGDNAISVLYADNFKTPAYYTGSYVIVSSLFYAAIVTKFAWIKAHNRNWGTEVAASASDKDSVRLTLTCVAIQIVAMCQMSYISANMRTNCRQLLGKVWPFTTTKVAAIDAGLNTQIRNINVNVVGSNRLAAQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6V0</accession>
    <name>A0A914H6V0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6V0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14556.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14556.t2"/>
        <property type="gene ID" value="Gr19_v10_g14556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037571993" evidence="2">
        <location>
            <begin position="23"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14556.t2"/>
        </source>
    </evidence>
    <sequence length="294" mass="32459" checksum="187DA686902C8AB4" modified="2023-02-22" version="1">MRVLPFHCLCIFALIIRQNSLSDHLQCFLCEGPCNCQGRQLSQKCVPNDRLHHPRCYSVKSVLTGQVLRKGCSADCESVEVSGWQKCQLCEGQMCNKNDDDDVSKTFLLNDCQMSQFFGALQTIHNNFRRESGLEGAATRDASSEGHLEESSQFVNGIDSSLFSPPKNKMQMAKTENKNDFGVQFQNVLERMSPSSEPIGLGKNLEPDRPQLVAQFGLPLSDAGQHFVVGQNLAQKTAVETGGGGPSRRVEAFGQQIERRQNSGGTTVPFLALNASAATLLFTLIQILFAWLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7H2</accession>
    <name>A0A914H7H2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H7H2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14534.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14534.t1"/>
        <property type="gene ID" value="Gr19_v10_g14534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="72"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14534.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="37445" checksum="2279A65AA1E44C97" modified="2023-02-22" version="1">MNAIAIGVEPDEEEVPVFPANHLRALQRAIATGVEPDEVLYAIATGVLSDEEEVSRSTESQCPTKVPSNRVLFGSHTGPYHDATYFVHLSIKESSGTNQCSGVLFSPSLILTSAHCWEFAHITGSTAHAVKDFVLHSAYYMAVNRYAFDLAIVEVEPAFDLVKGKLSTIGFASSEPAAFTSDRWSECQIAGNGHLFTEQGDKCSDKMQRLYMSGILISLKCCNDAVSQLGKPWGHKFPTGTICLRNNSEARCAGDSGSGVVCKYKPTGKKVLVGVLRAGPQCCDLNNNKFNYPIEHNVIPLDIARRRWISIIANNHFLFGTLTRPPPVESQTSTNGTVRDTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7S8</accession>
    <name>A0A914H7S8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7S8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14811.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14811.t2"/>
        <property type="gene ID" value="Gr19_v10_g14811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14811.t2"/>
        </source>
    </evidence>
    <sequence length="1255" mass="120479" checksum="6F99AE882CDE07C9" modified="2023-02-22" version="1">MAQIQALAKPQQRQQQNVFKQLLQVSFSLPFCQLLLFTAILFVVGTTLVETQSACRDCTQRGCFCIGEKGSLGPPGPQGPPGLGGTRGFPGPEGLQGPKGQKGAYGPPGPLGVKGDRGPVGTPGFPGNDGNPGHPGETGPLGLPGWDGCNGTDGFAGLPGLPGPPGLPGFPGQLGMNGLKGEPAIGFAGAPGEKGDSGTPGIPGFPGPPGRDGFPGLKGDRGDNGLPGPRGPPGEPGLPGNPGIGSIGPKGDPGDQGLPGQPGPPGPFELTGPSGSVVGPPGYPGGDLGLPGPPGPPGPAAFGLTQHKGTIVGPEGHPGGKGEKGEPGDTGPRGHPGQAGLSGQPGVPGMKGEKGLHGPAGPRGKEGRPGQPGPPGFKGDRGVDGLPGLPGPIGQKGEQGFPGRDGTKGEQGPTGPPGGGDFSDGPPGPPGLPGRTGNPGPPGNDGYPGPPGPPGPQGLPGGSGLPGLPGFEGAPGLRGEKGDSGVPGAPGVHGGPGLPGLPGSKGEPGHRGTPGLSIPGVPGRDGKLGLDGQSGRKGEMGLPGLRGPPGDSQNGLPGPPGFPGLPGPKGYDGRDGAPGLPGIPGQKGERGGECSACVPGAKGEKGFAGYPGLPGPQGDRGLPGMPGQAGDSGDDGLSGPIGPHGLPGPPGRDGLPGLPGLKGEPTLMKLRPGPPGYPGQKGDAGFPGPPGPQGLLGNDGIPGAPGSPGLEGPHGEPGVAGLPGKPGKDGLPGLPGLKGEPGYGFPGQSGLPGLKGEAGRPGVQGLQGPKGLPGPQPIMAPPGRPGKDGLPGMPGTKGESGFPGLPGTDGLPGLPGVNGAKGESGLPGMPGPEGPIGPAGLEGLPGNLGLPGLPGAKGQSGLPGAPGFPGQKGELGPSQPGLPGPPGFPGLKGGPGLSGLPGQPGFEGAPGVPGIPGEKGLPGLPGTSGAPGFPGIKGEPGYPGLPGKEGSEGSPGFSGMPGEKGVEGLPGLPGLSGQKGDSGFPGPQGQDGLPGAPGIPGLKGNTGLAGVPGPKGESGLHGQPGFPGEKGLEGLPGLPGLQGLKGQPGTPGFPGQDGMPGVPGVKGEAGFPGIPGAKGEAGFPGLPGTKGEEGFHGLPGQPGLQGPPGLPGFPGLKGETGMHGIGIPGVPGEKAFPAYRANPAGKVCRAREELTDCPVSPALKANRAILAKAVCPARTDFPDCLEQKAMLDCLAFPVCLVKKEHQVMPALRAFPATRASPGCPDCRANAEPMGLLVRKASQANPVYLAHPDRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7Y3</accession>
    <name>A0A914H7Y3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7Y3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15040.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15040.t1"/>
        <property type="gene ID" value="Gr19_v10_g15040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037999704" evidence="2">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="41"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15040.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="26283" checksum="E60E02DDFC5B3BE2" modified="2023-02-22" version="1">MRTFVLFMGAICFVVPALLLVADALPPKKSTSNSPSSSVNAEPNADASPSVDTTPVLTLQNQWDSEACNPGLTLSAEGLIAAYTGNNTGFRSVFAKKAIPNRESGIFYFEVKISPRTDENGEIVQPLTSGYVHIGFATKEMPLKKAVGLYEGAYAYESTGSVTGLRLHKPFGANDIVGCGINLKDRIVFYTKNGEHFATTKLSDNVTVDQLFPCVSLHNTGSKIEANFKLNGFKFDIKNGFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8H2</accession>
    <name>A0A914H8H2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8H2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15013.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15013.t1"/>
        <property type="gene ID" value="Gr19_v10_g15013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15013.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14470" checksum="8BDACBAD99306850" modified="2023-02-22" version="1">MPSGEKIGQRKREKGLFSLQRLMSLDSTLLERKSSSSVFRTPRPSSRASKRNYGSGSSVEEETDYEIKLAKLELLREQKKGQELLNEQHKLSIEKMHHEVETIRRQSHSSVSSSMGSTTGAYDQQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8N5</accession>
    <name>A0A914H8N5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">FAD-binding PCMH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g14824.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14824.t2"/>
        <property type="gene ID" value="Gr19_v10_g14824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057569">
        <property type="entry name" value="C2_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25330">
        <property type="entry name" value="C2_nem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="14">
        <location>
            <begin position="622"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14824.t2"/>
        </source>
    </evidence>
    <sequence length="1567" mass="175900" checksum="210D389F7B20403C" modified="2023-02-22" version="1">MPINSSFLISLIKAVPLCLIGFQFVVTDEILENLMNNLSSTTVQQPFWISTEVEQLHFRKECISAQLCAEPRFTLVNQMPKYNERLSHDWSMSKAEVPGISLEFFTFWGRGFLFIGIDPKFKFSRTCDESSYVSVFQFGAKVKGQNDEVYEKVQLELHGQCFNATLTIQLFRHRCPWCLIEQSEKLFAQLKDTEPFACQLPLQFRTNLLIILLAVATVINVIAFVVEQRCSPCPISKNRVLTTRAQRFLPTISEEFYEVIDDDDTETKPHIPLHFVHNLKPPPTCANSKDSKILPNMIEGCQNKILRTTLSYAFCFVCFLPLILLSFNWRVLTLKALQNLFSASDNANVSAPISSILNTRTNRCKIVPLWKCFDVMLKLHEYLDKYQPDSDLLMPTLPTDCGTKLLQFDSTTLTFFVNGIRIDVKSIDPRITLAAFLRDKLNLRGTKIGCNEGGCGACIIRECLPFPGVFSVGKAVTTVEGIGGGQKRIHPVQERLFACSWLPCGYCTPGFVMAMYTLLRNKPEPTYAEEICAVVTGYRPILEAFYSFTKQMDKKQIAVEKKSVVCHLMDLLKLKIAVILMEERLITKLSNLCTLPNIESSQELIFPPELTFGAWNQKSFMMENDGYYWYQPVKMEQWLALKREFPNARLMAGNTEIGVELKFRHIDLRRVINIKIFHLFEHFEVKKMDFVQFVDKLPNQKTKIFAEICNILSLFAGNHVRNMATVAGNMATASPISDLNPIWMASAYKQAQRREDDIAIVTGVFSVKFYQNKGPRVESMQMAFGGMGATTRMASKPTQNLKGRIWDEALFNDLSGALADEFRLPENVPGGMAKYRQALVLSFSLKFICTFENSLASHFESTQIYQDCLPSQNKTDPVGRPLMHSSGEKHTTGEAIYTTDVQLPSDCLYMAYVTSPVSCGKIIGNPDYSSALCLDGVIGHVDWRDVPGSLMISHSNDVPLFATDQTSISYHGQPIAAIIANDNETARRAASLVHFFERTKCKQLNRKLIGKKFSRTIKGQIRIGEGDEMHIISSTQSVNDVQGDVATVLGVARNVVTVTVRRIGGGFGGKESCTGLFAGAAAIAAKKFKKPIRFWLERFDDMAISGNRHPFRFDYQFALENDCDKIAAMEVNAYSNCGYSFDLSKGVMERALAHIDNVYKLAMLTYTAICAKQIWLLTPHSEASAFGIDVDTLRELNMYTTEGDITHYGMHLRQCNIRRCWTECQKLSNYDQQKLKLQEWNSKNKYLKRGIYMAGALVHVYTDGSVLISHGGMEMGQGLHTKIQQIASRCLGIDVSMIQIIDTATDKVPNASPTAASVGSDVNGLAVKNACEIILKRLEPLRKELPNESTWKDLVMHAYINRVQLSVTGFATIHCEPVDFTEGRGAEYYSYCVYGVGCAEVEVDCLTGDHRVIRVDIVMDVGESLNPAVDIGQIEGAFVQGFGLFTMEELKIRPDGVRLTRGPGTYKIPSADDAPRQFNVKLLDGSSNKNGIFSSKAIGEPPLFLGSAPFFAIREAIRNYRIQNGNLGYFRLDSPATPERIRLACEDSLLEKAIPQPSKGQRWTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H959</accession>
    <name>A0A914H959_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H959"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15365.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15365.t1"/>
        <property type="gene ID" value="Gr19_v10_g15365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="263"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15365.t1"/>
        </source>
    </evidence>
    <sequence length="465" mass="51619" checksum="B9B1F8CAD796AF11" modified="2023-02-22" version="1">MPKPNSSVGRIKHLLETGNGADVHFLVGGGDEKELLAAHKTILMVASDVFEAMFPFDARNADHSEETKPVEVPDVEVGAFKAMLSFIYVDDLSGLNGDNAIAVLYAAKKYDLPELVDSCLNFPIPELNNIFFAFVQTRFLGEEHIDVNAGALILSEEFLQIDQKLLCEILVRDELMISEEIAIWNAALRWADEKCRQNGKEPSAANRRAMLGPALFKIRFPLISQEDFENIVPSGVLTDAELVSILRHYLRPDRALPEPYQLQFPTNGRAETKSDGDGLTLQNRWDSAACHRDLTLIEPDRLIVQFNGNNGGSRSVLAEHPIPKNPPGSFYYEVTILEQEYFVSIGLATKQMPLDKWVGWNEGTYAYDGYGNVWGHEVAGCGHYNGRPYIKGKPKFGVRDVVGCGVDLATRQIIYTKNGQRLETAGFFVDSAVDLFPCVPLYNPGTKIEANFGPNFKFNIAADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H962</accession>
    <name>A0A914H962_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPPDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H962"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14953.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14953.t1"/>
        <property type="gene ID" value="Gr19_v10_g14953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14953.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13157" checksum="1539B47CE7A90D8D" modified="2023-02-22" version="1">MVARYLSSLNPVYTPGARVSCPVSKYLIHTALEVLYRGSSCGHEVHVTYETMGPGELSKEFGRYTKTYPPTELSGIKTTAYEDIENVFSDMWTNYNFVYKNCKRWTNDLIKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-06-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9U0</accession>
    <name>A0A914H9U0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g15128.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15128.t1"/>
        <property type="gene ID" value="Gr19_v10_g15128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15128.t1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6784" checksum="97DCC9A18C8FB72C" modified="2023-02-22" version="1">XVRRHCWTDFDGLEQKQTFSLITNVFIDQFLLMHSANVFIDQFLLMHSGQKALLDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9Y7</accession>
    <name>A0A914H9Y7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914H9Y7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15582.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15582.t1"/>
        <property type="gene ID" value="Gr19_v10_g15582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="219"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15582.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32162" checksum="8DD3355647DB276F" modified="2023-02-22" version="1">MAYSFAVADASEQLTAQRRDEEQMRRIYDKMSDCVLRLFGERVWMRWHRWLPAVASLIYLTATNLRVRQTVGEEYVGLVQVGADGRFPRLASRLLLVLAEFVVQAPLLNVLIMAMTTQHPLVHQTILQLNAVFGIHHIHSAWFFLFNSFYLRLSKRLSSIRYLSLRPQLNSVPPILFQLIGFATLAQFAVVLMSSIAKLVKQQSVAVCDERSHKSEFFCKICSTKLNKVRRPVCFPCGHLLCSDCLVSLCSRDKGNSAAFIECPFCRVKFPLHRIIFPLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAT0</accession>
    <name>A0A914HAT0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin assembly factor 1 subunit A dimerization domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAT0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g158.t1">
        <property type="protein sequence ID" value="Gr19_v10_g158.t1"/>
        <property type="gene ID" value="Gr19_v10_g158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g158.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41640" checksum="362C176E323D8C58" modified="2023-02-22" version="1">MVKGTPKTPKTPRTTQTTPTPSRTPKRKETTNKQVAQEPQEDGAESTNKDDSVKRPRQATISTYFHRVDKPAPPPTVPPSILNTRFRPFQLKEGMRMAPVLVRKPLSDKDRDNLLTITEPFKYLAYCKTKRQKQAATNIDALKPKYYHFHDNYRPPYLGTWRRRSAQITGRRPFGQEETLNYEENSDDDWEEEPDDADECKSDEEDIETSQDDDVMDEEENDGFFVDHGYLSSDEGSDCANEDGDADDDSDGEKKQRKRNASAKDAGETEEQRRKRLAQKAQEWHESVRQKERRARKREELKPTLFMPMGVDVQHLSSSAAHMVHFCLPAIRFDYSKLVSVEEMDQTGEPGPSTAAAAAVLNDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBP8</accession>
    <name>A0A914HBP8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-tyrosine sulfotransferase</fullName>
            <ecNumber evidence="8">2.8.2.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-tyrosyl-[protein] + 3'-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16801"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:11688"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:65286"/>
            <dbReference type="EC" id="2.8.2.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the protein sulfotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.20" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914HBP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15873.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15873.t2"/>
        <property type="gene ID" value="Gr19_v10_g15873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002853">
        <property type="entry name" value="Protein-tyrosine sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="817"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="736"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15873.t2"/>
        </source>
    </evidence>
    <sequence length="906" mass="101628" checksum="9F5757C2C264CD98" modified="2023-02-22" version="1">MAWKERKEQIRKPLLALRNRQNSNPQNEGFFKFLYSEITTKVQQFVERDSHQTGHERLSVNFDHNLRTGTIQFEHNTMRFTLNDLPCIIEMMKTLDNKTVYKIADLCQMIVVSAPKHEPRKEEPEELGDSKLERYQWPDGICPPLKNVRRKRFRKIKKKRYMDVADVERELKRLLRSDLEAVSVRWEVVAATEAEDVEMKQPQPTNVEKNEEVASQHDDLYEYGLSLSESEDEQEADGSRTFAQRHSDGGIAPSAVDTLAAFIFIGGIPRSGTTLMRAMLDAHPEVRCGEETRVIPRILALRAQWKKSEKEWKRLREAGVSDEVLNSAVSAFIVNIIVGHGAQAPRLCNKDPFTLKSTTDGRATVHSIISRKVTITGFDLNNFRQCLQKWNAGIQIMYEQCNAVGRAKCLPVYYEQLVLHPERVMKRLLNFLNLPWNESVLHHEMFIGKDISLSKVERSTDQVIKPLNLDALNKWVGQVPEDVVNQMDEIAPMLRVLGYDPNANPPNYGQADEEVLKKTEQLHREELKWNRKAQEVLKDEPRLINYLRASLLDDPNCSPSVHPTKGFFFGFFKGGVITPPFILDGWRMNWGVFVQQMSPPPGSSRMSTLPPFLTLIVSIAMSQALVQAIPRYVDRIPRQSAGGGDTPRPSPSPSPLQNHFPTAVAANSSRAAFASKLVPSTVDDAGQIPRHQPTVPQFVANNGPLIRAPDGQFVLASVVPQQQQSVSFTHGQIQPIGLHSSRSTNDSDQLSPSVPPIGDVQAEVSPPPDGPTPANLTPDTLSPSPPASPLDKSVDLDGDGALSLGEVQYAAFVHHGLSSSVVENLFNEVDHNKDGYLNSPEFNDIRPLVLAKAENAALRYLQNVDTDHNGLLSLSEAQSYILKEYGISNRDVERIWRLVVPSVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEJ2</accession>
    <name>A0A914HEJ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEJ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16412.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16412.t1"/>
        <property type="gene ID" value="Gr19_v10_g16412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF11">
        <property type="entry name" value="LD29223P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16412.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="28883" checksum="BAFA39D32712ECB0" modified="2023-02-22" version="1">MSYAEFRSFIETVHSLHQIPFTLCYTSYTGDLLPITNDDNFRKSLDSARPYLQLLIQRKGESWEEKFLQLSMLTLCLPVIGADGTSLRMTHQGPVKCEGIFISRLVEGGLAESTGLLSVGDEVVEVNGIEVNGKKLDQVADMMVANAHNLIVTIKPANQRNSLQRRGKTNPFGAQGQYVSNQQQFFTGEGSSSAAVVKLGGFGLGTGGGGGKVYPTGQGVTSYQTGPSRHPLHLNELDDDYVEDDDDEEEDEIVDHTKNALKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGR0</accession>
    <name>A0A914HGR0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dopey N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g16810.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16810.t1"/>
        <property type="gene ID" value="Gr19_v10_g16810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="7">
        <location>
            <begin position="1451"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="6">
        <location>
            <begin position="2367"/>
            <end position="2721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1242"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1424"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1483"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2277"/>
            <end position="2372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2722"/>
            <end position="2743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2757"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1496"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2294"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="2315"/>
            <end position="2330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16810.t1"/>
        </source>
    </evidence>
    <sequence length="2816" mass="310084" checksum="ABCD97C6C9D562BC" modified="2023-02-22" version="1">MSASGSHHSEASTSSSFLLGSTFSTQQNTSKYRAYASAVDKALKSFESTTEWADLIAALGKLGKVFASNSKSFSDIPNPLTVAKRLSQCLHPALPSGVHLKALETYRQVFNILGHSGRNQNLARSLFLYAIGLFPLIDHCGIKVKSELLSIFEHYLLPLGIDLRPALPGFITAVLLALEEGTEFYGRAFKLLDQLLDKVGSDAFYTCLWQAVGGSSSVRLPALIFMNAKLEKRKSAQPSAELLHTLAGGGSVAASSSADCHHQQQHMLRALCAVADDASSSSALAQRHLLDFLCTAIPFDSGWVPRRELIQLLRRCMFIVLRRDMSLNRRLYQWLLNRSNDVAFVGLPVNGTEESVDLVFFKQYTLPLIKMAIRDYLHSADTVEVPPLSTGTIRRYGTLLKDPQIQFPEVRVCRILHYMLDRPELGQMVLEESLADLLETICARDMDLVRDMQSDCEKLEPNFECFWNVHTMTMDDEQSNRRADEIKKNFNVLLNSLDPGFLWNFFKKFFSNSVNDANAVDDGGEKNSGRDKSNNHGAPLFPLMVAFCVRNVQLDSHGDIRGRHLPELLQNVLSGMVTMCQQRHSTAASDDDVDNNSGTSLCCASTECCMLANIVLCRRLLAEITQNNLSMVFEHIHDDSESSPSKKGIKCNEELAEEQKLVERCLTACLCLLTAVCEWYCADRERRLVGVLAALFALMRDFADFPFYSLQLHNNSPQHQSTACRSLTDSLHAETGGHHQMPAWLCSVLRLIDPPTWATSKFGFDFELRNQLFDLLLYMCVRSASMIEQHTAVFGRALSQRSAKGQPKQKTTTTVLLKPFLSLADLQRIEQEGLCRKAAAVLWRRFADEQTTAAADVDALMPIALLLLRLHSRRVSETSSEVEDIVVTELTSANKVLSGGAVRKFRDLWVFCRNAVIEEVYTGILLKPMNRVVMVLLGFIADDKLCTEQVELRALAYSWFMDCAHHNELHKIVQMLTLMLLNPVTTRVSIQFVQMRKRVTREQLSSMPAEANCVALTTVSGKQTFHHVCTDVEQRRHGNAWNNYSYVDCDPRMAWVSDLNKQLLLSDGGSNNVNGSFSGFSTPVHQQQHGHQNGWVMMNNNGSNNNNCSKNVSSPSPSFDATQMSAQLPQHNTSALSMAMIGSGNTTSSAKGHRRTMSDIPQFDGDAESVDSYSMDTSMLDSEVVEAVQYLVDSVCDEEVDEEEEGTKPCIDGDEDIGELEELATNMLDQALLDEDERSTVTPVVTRRQRQRGGDVQSGADGDMFNRSADKRKRCASAVRESTYDQTSLVGSLLGPGDAAAAVPRITSYAGGDTIRRIRTGHRRQDSLQESIFSTGTQELRLFDPTELPNSTCPGDHKQPLLDETFSHMLFYAESPSIVDLGRAEKLFRTIGTLLRSGNNSGLGRHLVNCMLFTNMAELVNRAGSSSSNCKSSGSNGSSNSGVNTTTNSVATIGGASVAATQQLLDFMARHYQHIQGEGFWSTAQDNGGQKEDGATASNSENKTGQQRHSTLFEIFSTVVLYFFRSYYLNSPTNHVSETDLVLSWKCKIAALDCFTVLLNILDDIVKEASSKELATFVQQIYRQTKTQKVILTLMLAAIPTPPNQKDWRMPLSMDIAEFNNGPSHSVHFRDLIFAYHRSLLSLASALVVLEYSLHVGTRHFSSQSHFGFPISRNSSPSSQITENQINYNSSQNRSTIREARYSVVELRLFLGVILNALKRCPARHELWLHFLIGILPYLDRALATFVVHTVEQICRNLYESVFINGSAVSALNTPPPLMTRVNHQISSVLEHPKNPIQFVDYRISRTNDLAPMLDDSGVMPVIYPANYVLMLVESLLSLMHFCLLDTHNNNTSMFSLSPFLPSTKHSVAALAHPLQPNFHQQSVTPLRYSVVASTGATGGGGGGGGGAFSSSNMTSMVGSAISVIPGTGLINNLFGRVFTSGENPSNIATRADASGKSAEMLEAQRELIKRFPSALAIFIDVWAFTEQQRRRGGTNTSTPKVGTFKSLSTLILDILNPVAKRHKNALMNSLGVVWMFRDFHASGIKMSDNCRCSFVYSHQQIEVANLALNLKSLSLTSIICSVSDTLKESANKTTKSSSSSSTGSDKIGAAGGGFSLEVAMLEMLHQCTRQVSVNELRESWAALAILFNDTPLAQLPARASFLEFAILTDFVRRCGSQAIIEDKQISKAILDVCQKLIEAINVVVGWQLESTTWLKRTLVVRQDASTSQKMAASSDLSPVLEQRGGSVVGGASVSSFGAAPLLSSASALASESNSMRGSTISLTGGGGGGTTTAHGPSSRLSFPLDTQSMTTASCGGGGGGTVTGGGGGRVLPTPSTAAAGGGGGTSSASSVLRSSMKDSSSGSGANKKDPSDSTQALFLLAENLAELIDSVCKSEDKEKLLPALQAVWNNTLPYLKAKSAKNVRFFLASSQFLASMSSYNYMRSVWKKNAMDLLWDNSFFKMDIHSLRQWLIVIDNLMTNDKTSFKELLTRITTSTSTTLSTLITSKEQEYEMRAQYLKRLAFVILSSELDQYAGQLNEIQERLTENLRLCQVPVIHTQVFTCYRVLLVRMSPSSFVSIWPSMVTELVQVLAQIDHQLSSASGTGSGGGGSVDEQKSARDEQCMQLFLAACKLLETLCTLPSGYMSQFQMCRWTFISPMNAMSVSDVFVPYAVRLNHLLNNRYTELTGADIEMRSASLFNIKTLTSYQELHPFFHALTMQNGGGSSRGRQQSSHHNDEHHQHHKYMLYNGRLDGDSNAIDHEEGTGTDNAELDKNHDTAPRLRDAELLNGSQSLKNAVARIEHSLYVDFAEHWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHJ2</accession>
    <name>A0A914HHJ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHJ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16682.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16682.t1"/>
        <property type="gene ID" value="Gr19_v10_g16682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF88">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="68"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16682.t1"/>
        </source>
    </evidence>
    <sequence length="668" mass="75488" checksum="C39C75E148123450" modified="2023-02-22" version="1">MTETGRLRFAFGTLTLFFIFICLEIQIYSPTKNLIRKMEADMPECLRQSPREFEFDAKFAVAFSDWFSLLRGLPEVFTALGLLFFAGIRNSSILAVTPFLILALGIDDAFLMIHSWQLASKRRHNSATKAHDELPVNMAVAELLAEMLEETGTAILISALTNIFADLVGAFIGSEEITLLYVGNIACLNACIYICLALLSFEINLTLKKLFPSDSPLLEIEKHREEKVLPFYTTAQLFVNNPGDLSNATRRRHLNELIEQMEQLKYAYPAESSLYFVRTYEEFETFMRDDDSDFLCGVSENNNNSSKSTREEHQFDLSDLDTFLNWPEFRHWRGLLKFHNQLDKDGAGQVRNRTVLDTLMATVAYHGDDLQNWYNRALMLRDWRNVVDKYVAEFNVSVLHDDGLYLDLLENMEHFFNAQGLGHPFGVFVLSFSASDEPSGSSRSLSLRSFPSSAVRKHPPPLIRCVHSFYAFWARFIVKNAWGVILFCILFVPAGAAPMSEDELKKTIEHMEDKVTFASQTWFLVFAVVAMVAALVAWIAFIYKEVRDSREAMGTDLKKVETKVETKLDAMNTKVDAMNTKVETKLDAMNTTLSELKHMMANGRAGQNAQRHPVINANVGHQNGDPVINANVGHQNGNPVINADVGHQNEDLAINATLFTKMSNSTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HII3</accession>
    <name>A0A914HII3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tropomodulin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HII3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17685.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17685.t2"/>
        <property type="gene ID" value="Gr19_v10_g17685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF16">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17685.t2"/>
        </source>
    </evidence>
    <sequence length="601" mass="66608" checksum="397A5B6C6E91DEE1" modified="2023-02-22" version="1">MGPIGRRCLRHAPMCHTLYRISTDRSIDGSEDTNRQKAKSQIRLLLAEEHRSIWPNMDAEEPVEDEQVMTDADFERAMEQLREEGGEDVNELLMAMSENRIISWEEAEHILGNSSNEPVKSSLPQQTRPTEPDNDTDVDWCVQRLLNNDPKLVEINLNNMKRTPIPKIKRVIEACRDNEHMEKLSLANMGLYDLDVQPLIDILEHNSTLRCVNLETNYLSGDFFARLFKAALTNQTLEEVKAVNQGVAFSTTAEREMIEAITENRGLTKVSINLRLPEGRFKIEQTMIRNQEIRRILRRQEAAAQVAAAEKAKGPLTTRPPKETEAKKRANERKVNVQELLARKSTPSKLAVAGAAAQPKAGSSASSPSAAEKSVLREKARDMEREAMKPKEDMTAERVLLSERLRETGVDSGVAARRAKFGEKASPADDKSDEKATKKGPKREEKKPDEAADKTKRKDVPSWREKLADRDAKAKELAEPVQKSAESPNSKKTPTAKSATKANNSPPPSKTSSKSPSKAPPAERKESKDSTTPAATTTTKKVPKKTTKPKDGTADDKGTAAAAAAAKSAAEKVRPETAPKATPTERAPLASWRDRMNAPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIR9</accession>
    <name>A0A914HIR9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIR9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1834.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1834.t1"/>
        <property type="gene ID" value="Gr19_v10_g1834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="303"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1834.t1"/>
        </source>
    </evidence>
    <sequence length="505" mass="58235" checksum="8A4A25C51DF4B777" modified="2023-02-22" version="1">MSFSIESTNEGDITADQEHLWPTFANLDPSEELRRLRDRIDQLELQQSINSSTSSDGFDLVAQNGNEFVNDTLGEQNIIEEELKTELELKEVKEELEYMKKELSDMKLYKEELKDMKLYKEELKDIKQYKDEMKKTNELVSKQFEQMEAWKRVAKLELENKALHTELEHQKLLNAHKDIATTTAEIKLNVEILKQQQNQTDKIVSMQAANAEQQKADQKALCETMIDQQCKEHDEKMNEFLVCVVEGQNKKFEQQMETDRTMLKKQMDELEISWKKQLEEGMNRLKGELSAKMEQYQKQLRQKNIDALTDETQQGNGLMPQQNRWDAAACHNKLTLIEPDRLIVEITEKDKWAWRSVRAEWPIPNGNSGFFYYEVKILVQKDVGIHIGLTVKQMPLDKWVGCCDGTYAYEDDGTFWGHVPVDDCAYLDGRPYIDAGIPEFGVGDVIGCGLDLASRQIIYTKNGRRLETAGLFVDSAGVELFACVSLSDSGDKIEANFGPNFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIW2</accession>
    <name>A0A914HIW2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17794.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17794.t1"/>
        <property type="gene ID" value="Gr19_v10_g17794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="29"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17794.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48271" checksum="3A9C3B2C9DDC902F" modified="2023-02-22" version="1">MHADILTWVKLCITCQLRHSPTPAYREEMMMVPANTLFAKVGLDLAGPFPMTQKGNKHILNIVCWFTKYVISVPVPDTKARTIAQAFLNHCYLKFGGCTELITDNATAFTSDFFREFCSMLYIDKKYACPHWSQGNASTERTFRTFHNILAKYISRNQPDFDEFLDAACFCYNTSVHASTGESPFFLMFARDPVFCVDQIIDPKVRDPVAISDRGEFKQKMVVAIRQAWHAAAEEYAKAQLKMKEQYDRRARPQQVQAGDRVLIRNYEGRANTSKKFQLPWKGIFRVVEVEGVHVTVVSCSAPNSTPKRLHMNQVKKCFEMLGPACTVPALPADEKEALEAAGAAAEEVRGRGEEFLPSGGGDDAEEETQNLEDSQLKDETINLACGPKAVKNGSDGEVGQGPTEPSSSEHRRYNLRPKTRTWRDLANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ83</accession>
    <name>A0A914HJ83_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A914HJ83"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17136.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17136.t1"/>
        <property type="gene ID" value="Gr19_v10_g17136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="134"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="240"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="543"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1025"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17136.t1"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124412" checksum="41D0C653F9676E21" modified="2023-02-22" version="1">MVKSPKKSPAKRHVSSQPLAKRAKTEFSSILVQQNGNSAKHISFENRLAKLDVEDGGLHAASTSSGHVSARQPGAEAKWPRPPLAKWLQSGRTDVDLAFQLIDIDFYTERTGVIVRMFGVTNCGNSIVVSVPGYRPYFFASAPLGFDQSHIPAAISLLNSNISISAQSGIPKDAPTMVTDIELVFGSNLFGFHAELRQQLFLKIFVLSPRIITACSRVLYLLEKIGADEVGHLANFRPCQAFEANLDFEVRFMADLGLVGCGWAECPARKFTHVDPKHRNTNCQIEVSINVNDLKVHLADEPQWSHIAPLRTLSFDIECIGPIGTFPDASRDPIIQIANMVKVEGQKEEFVRNCFVVGGCETVVGSDIVECRDEKELLEKWAVFVRCVDPDLLTGYNIQNFDLPYILDRARHLKIDKSVCLLSRVRGAMCRQRDAAMQSKQMGNRVNKLVSMDGRIIFDVLQLVLRDYKLRSYTLNNVSYFFLGEQKEDVSYTFIPQLQNGSDKDRRRLALYCMKDAFLPLRLLDKLMLVINYIEMARVTGCPLNFLVSRGQQVKILSMLLRKTREHHLFLPVVDVAEGGGGDEVGYEGATVIEPLRAFYKDPIATLDFASLYPSIMIAHNLCYTTLLPKGGAKKMPPNWREGEDFIVTPSGDTFVKSSHRQGLLPKVLEELLSARKRAKAELKNEKDPFRQMVLNGRQLALKVSANSVYGFTGASRGKLPCLEISQSVTAFGRQMIEATKQMVEEHYVAGAVDGLCPANAKVIYGDTDSVMVKFGVKSVGEAMELGRHAAREISKRFPQPIQLEFEKVYHPYLLVNKKRYAGLYWTKEERHDKMDCKGLETVRRDNCQLVSLVLNTCLEKLLIDRDDRAAIGYAKKVISELLCGHIDISMLIISKELTKKGEKYVAKQAHVELAERMRKRDPGSAPRLGDRVPYVIVNRSGGGVSAPAYEKAEDPTFVLQNNIPIDFDYYLEHQLVKPLARILDPVMGDQAEKLLISGEHTKKKARTKLKSGMMAGYFSKKAVCLGCKTRMDFEEEEAPAACEQCQPRIDKIYLEQILTMRQIEHKFSRLWTECQNCAETLQSEIFCSARDCPIFYMREKNSNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJH0</accession>
    <name>A0A914HJH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1775.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1775.t1"/>
        <property type="gene ID" value="Gr19_v10_g1775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1775.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13265" checksum="CE1880A4AE929EB7" modified="2023-02-22" version="1">MQSLATVLFRQSLATATVETTAARRRRRRKRMRSLNVEQQPQQTQAGNNNNGQQRWKCRLVLAFAVLTIVTLLYAITLFARHRTANNESFMLINLIAFVLSEGTYIFCCSNLINSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK62</accession>
    <name>A0A914HK62_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="7">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7 8">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HK62"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1876.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1876.t1"/>
        <property type="gene ID" value="Gr19_v10_g1876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045251">
        <property type="term" value="C:electron transfer flavoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="294"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1876.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="36069" checksum="0AD0CF6374B65FD7" modified="2023-02-22" version="1">MLISAFSPGRTAATTRIASFLRHINVSRSASTLVLAEHNEQKLNPVTLNAVSAAKKLGHDIALLVAGKNAEEVAKSAATIPGVKQVLFAQDASLEALLPERVAPVLVAVQRSLGATHVLASATAFTRAVVPRAAAMCDVSPISEISAVIGDDTFTRPTYAGNAIAKVKSSASVKFITVRATAFEPSPADGGSAAVQKAPDFSPPPADVVELSAFLGQELSKSERPELAGAKIVISGGRGLKSGDNFSLLYALADVLGAAVGASRAAVDAGYVPNDMQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKLIVAINKDKDAPIFQVADFGLVADLFKAVPELTEELKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKR1</accession>
    <name>A0A914HKR1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKR1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17528.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17528.t1"/>
        <property type="gene ID" value="Gr19_v10_g17528"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17528.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24498" checksum="4DECF88875D05004" modified="2023-02-22" version="1">MLASTSSNTDINHCEHDDSHSFLMLPSTSTDKLKERNKCTADESDSDSDVFGDFEMANQTATNDSNGICAEEAKPSTENRPLHSPSSDQKVKHLPFTMQISQLLEETWKASKTEFDDILQVPPVDAPMANLFPLFSTDGADELTEIDGFTLKSFRLWEQICRLEETRLLQIRWDNSRGSELLMKALSSTRNEFKGPKSPKGKHLETTRTQSSCFKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKV0</accession>
    <name>A0A914HKV0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2064.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2064.t1"/>
        <property type="gene ID" value="Gr19_v10_g2064"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038092777" evidence="2">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2064.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15935" checksum="CE0C69B7154A7965" modified="2023-02-22" version="1">MLFYPLFLPNLLLTLLGIASVAGNSPSKQKHASVSTHSMEISGTAPKHKNVPRIILNGRTLEIPEGSNPVHVLNSHMAAIRTAQLEKNTQKNREIKPSASGGRDEGFATAERDETSSTTRRDEATATARRARSRRAREQHGEDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL94</accession>
    <name>A0A914HL94_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL94"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2369.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2369.t1"/>
        <property type="gene ID" value="Gr19_v10_g2369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2369.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11643" checksum="7341455689CD8A3A" modified="2023-02-22" version="1">MVNFWMFYSQSRPAQAPVLASYRKGRREMSPTVMESRRPFPPPLQLSAIGTNRAEEEVSATVESGPGQLDVTALTHGRDYYAIALADVSSNGSEKDDGENNGYAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLL5</accession>
    <name>A0A914HLL5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLL5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g263.t2">
        <property type="protein sequence ID" value="Gr19_v10_g263.t2"/>
        <property type="gene ID" value="Gr19_v10_g263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003134">
        <property type="entry name" value="Hs1_Cortactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF23">
        <property type="entry name" value="CORTACTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02218">
        <property type="entry name" value="HS1_rep"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51090">
        <property type="entry name" value="CORTACTIN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="609"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g263.t2"/>
        </source>
    </evidence>
    <sequence length="669" mass="74352" checksum="61603AC1FD780FBA" modified="2023-02-22" version="1">MSLGVKPAPPLKPAQEDEDDWETDPDFLNNVSEKEDVLKSDQIEKERKFALMPKPSDGYGGKFGVQHDRVDQCAVGFDYQGKVEGHASQRDYSHGFGGAFGVQTDRVDKSALGWDSRETLQKHESQKDYKMGFGGQFGIQSDRKDKSAAGWDEREQVAKHESQTDYKKGFGGQFGVQSDRRDKSALGWEEVEKVKPHESQTDYKKGFGGQFGVQSDRKDKSALGWDECEKLQSHESQTDYKKGFGGQFGVQSDRRDKSALGWEEHEKVEKHESQTDYKKGFGGQFGVQSGRQDKSALGWEEKQREVGGGRQAIEVPKPTEEAAQSQSKSDGVETCKGAAKSLRSKFEQMAMQGDQQNLDRARGERERRKREDEQLRLRQEAEERQRQQRLDEQWAKQSEDGVNEEGGQSVQQQQPRQRPSIGVRLPYATSAATSLEQQQQQRRSTADDHSTESETAAAAVEAEPHPPPVKVLPTVAESPQLKALTVPMGSVGGIIRAVQRISAVLEKAEEEEEEGRLGESAEWADETADPTQEVGEYGERQQQHVTSQHQYELPPIVADDVENDGITVAVAAAHSSEEADQNVPPSDPTPMAAAAASVEGTALPITSAAVGMTAIALFEYERQDDDEIGFEVNDLITDIEQIDVGWWRGVCKGRYGLFPANYVQLTERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNA2</accession>
    <name>A0A914HNA2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNA2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2348.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2348.t1"/>
        <property type="gene ID" value="Gr19_v10_g2348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2348.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14236" checksum="9F1EDBEA611EBC3B" modified="2023-02-22" version="1">MDFDDPFEVLELNPCSDKVKIKTAYRQMALKCHPDKTRTADTEPFRRIKKAYDYLWKMAADKLAQFARNFTAQKGHRELVQFLIIAAQNGQINEARSLLKRGADPRGTGTVTVTVDGQMISGRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNW1</accession>
    <name>A0A914HNW1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNW1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2534.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2534.t1"/>
        <property type="gene ID" value="Gr19_v10_g2534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037747503" evidence="2">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2534.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17512" checksum="6F8F3DB9943004D6" modified="2023-02-22" version="1">MFRKISLAACIHFGVLSVVTGLKCQKEFALFEPESQFSDNTLEIECAIQSHRCIYVKCTAHSTGKAIPFTENVGCEDPKRVNCTKLGDECNIKGGKICCQTCATDLCNVEKICEGNVTITLKGGPAMTAGGVAAVRARVGVVVLLPVLSLLLNFFAICFTKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPG2</accession>
    <name>A0A914HPG2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HPG2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3011.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3011.t1"/>
        <property type="gene ID" value="Gr19_v10_g3011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000039">
        <property type="entry name" value="Neuronal SYmmetry"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF51">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3011.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42646" checksum="5982DA9BE7C36AB5" modified="2023-02-22" version="1">MAEPVRKAVIFCACVFTMIGMGLSLAAILTPSWQVVNLQEYNSVHEHGLWLDCIRHSRDGGGVLLRRYATLSEPLHCVYKFDYDKYSGTFDLEDDNSPVGEVNRHRFYGWHTATLIMLALALLTGFCSVCLGACGCCYASLSLVFTATALLTTFLSSVAEGVFFFFSHRADNRFIKGIVGTYEQRVGLAFFLQMGACFFHFVAFLIAMVATYFAFTRKGVALDRERYSLQTSSKTNMTNVGRPMDRLPLLQQLAPPPSFHSADRFDRGPTPQSLSMATAPAALSAHRMTPNFVFPISASSTPIRREASMDFEHPVFVHNQMPAPSAKPRMPPYMKQQQNVQQQNSSDDFDRAVADSMPELHNRSFQSDFSGRIRRKSETCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQA6</accession>
    <name>A0A914HQA6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQA6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3250.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3250.t1"/>
        <property type="gene ID" value="Gr19_v10_g3250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3250.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24702" checksum="599E13D86A0A06C7" modified="2023-02-22" version="1">MALFSTNLLDKSESVKLELKTFDEIFGEGWWEKGEAEDLKTPAPTNFGQNVPHQIDRQNTEIGQIEPNSTDQLGEIEPNSTDQNPPLTKSDHSDNAKNGEEKNNLSSNESIAEDERKPKLKRAGFKNSYKHEIDETVAKELGLSFGTISNWKRKLGQSKLNHIYGHSEQKELMKLYYEWKRQFKRQQFHPNSVDGHFVEENAAANVQEIGNSNSGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR35</accession>
    <name>A0A914HR35_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HR35"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3682.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3682.t1"/>
        <property type="gene ID" value="Gr19_v10_g3682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3682.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38936" checksum="3074ED9F60E8B8C0" modified="2023-02-22" version="1">MDFVDWSISVQIPISYLTICICIPSTALYIAEIVTIVRHKKFHKSFYALFVMRAILDLLYVLNSFYGQRLPFLFGVLYPIYSKFPNWMLAMYFFIAGHTFQANNLVTAFILLNRLTAIIMPTKHEKIWQKFIPFITIFVYGVPTLLLLPAFKMDAILILNDPNSTTDRSFLVYEAGDAPINNYLAYICAVFSVIFMIICVLLNICTFVAYKLHMKKVSINGNNNFDDVEKKLLFYALATFLGHLLVASIFLINIITKIDDWKTTFTIFVYYPMMLDTGTVVLSSWLLLWASSTFRQELIKDFSIIRKTNIQIIRVGAMEGPRNNNHRAVGWPSIAEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS88</accession>
    <name>A0A914HS88_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS88"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3479.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3479.t1"/>
        <property type="gene ID" value="Gr19_v10_g3479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="1">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3479.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16155" checksum="DFDE7AE30BBA4457" modified="2023-02-22" version="1">MFACSLFWKSSMDQNLAFRKANLRSENFGTRPAQNGYARAQWGNIEIMALMQARVDANTLIVMAGFALPVEATETRVNAQAQAYEYMTNYSESCEPVGRLEKVVGCPLTNNTRLPVPFPIAEMKQLNTENLKQQQNQMSLSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSF7</accession>
    <name>A0A914HSF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3338.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3338.t1"/>
        <property type="gene ID" value="Gr19_v10_g3338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3338.t1"/>
        </source>
    </evidence>
    <sequence length="450" mass="51551" checksum="8BCFA28B2FE05545" modified="2023-02-22" version="1">MEKNPADWWFYFEKTIDRNEAKCKFCNWSKDRGKGKYTSILKNHLEKKHPTEYQQKVNAERARNEDGMQKKRKVDNEMVTAYFKPIEDNDVRTSTSQKIRPETPNKPYPLFNRSSWSDPEKSGKLDHLIAEMIPVDFQPYSFVDDEGFKRLLNFLAPGYQQKGRKYYTERAVPQIFLMRVQFMALTKNNTVNECKFVRLPGSQIAARGQRWNRMAQCEWEEWAKMEGAKIVNQPGFKRNKILAMATILDPRFKMEYFEDFLLPEFRILLEREAQLSAEFGDLVDANECCDSSPVLEGGFFAVMQKQKRTRSIDVASPIPDVSSLTSSQSNDSKTFAMVQVAEYLSEQCIPLSASPFSYWLSRKNSGKWPLLSALAMKYLCAPCGSVENTCGLRQNRPLRPDIWGSDICGSDICGPTFAATCGLRQNRPLRPDIWGSDICGPDICGQTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT26</accession>
    <name>A0A914HT26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4391.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4391.t1"/>
        <property type="gene ID" value="Gr19_v10_g4391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037134473" evidence="2">
        <location>
            <begin position="22"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4391.t1"/>
        </source>
    </evidence>
    <sequence length="441" mass="48605" checksum="38C661395EF12027" modified="2023-02-22" version="1">MSFNWLLLFLLLPPLLFVVLADNNSQRQRQFNCPNGGEPKADERTGKPLQCLPGRRSSSAICGLHHSCFFSGFNYQCCPSLSEDEDENNFVNQQSIETEHRQQPTADDDMAAENECPAGSFSVFGPEGALLRCGRLRSQTECSKPSMFCHVGVSMQICCERFESDGPLHQSPHQTQVSGEVIVPTSSREAVWHSTDGQSRGEADAVGHSIDRGEADAVGHSIDRGEADAVGHSIDKGEADAVGHSIDRGEADAVGHSTDGGEANDEKSKRQPQFQPPPHGTSSNRSTSPMPTLDMKDGESSAESVRPSLSSAERPPPFKPKNIIQQAAKTAQRIGQDEDEHGTGSKEQKSNTNNFNKFNNNNNNNKEEEYAPTKLLKEFSNVADEPAQQHRTASQQYILEKISDGWPYDDKFYRPTNNNNNEDIFVMRKRGRPSAIVYLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT69</accession>
    <name>A0A914HT69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3994.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3994.t1"/>
        <property type="gene ID" value="Gr19_v10_g3994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3994.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15763" checksum="F48AA5969777B8E2" modified="2023-02-22" version="1">MALFATNLFDKTESVKLELKTFDEIFGEGWWDKGEAAEDLKTPAPTNFGQNVHHQIDRQTPKLDKLNLIQLISLDKLNPIQLISLDKLNPIQLIKLDKLNPIQLISLDKLNPIQLIRILLSGNLITLIMPKMVKNRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTX8</accession>
    <name>A0A914HTX8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTX8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4435.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4435.t1"/>
        <property type="gene ID" value="Gr19_v10_g4435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4435.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8720" checksum="752F3D7738D2592C" modified="2023-02-22" version="1">MADAIRGSVTVEQEDGRPDQQHSYSPTFSESQLELLEKVFASTHYPDCFHREELAEKVHATEDRVQQWFQVLARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTZ3</accession>
    <name>A0A914HTZ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3957.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3957.t1"/>
        <property type="gene ID" value="Gr19_v10_g3957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036918047" evidence="2">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3957.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32482" checksum="AD8E1F44FA5E931E" modified="2023-02-22" version="1">MEEFWISILVLFFATNLIDKAEFVQLEELENLQLQTFDEIFGEGWWDNDKADEWDKLSLEQNVLHQIDRQNTQTGQIEPNSTDKLGQIELNSTDQNPPLTDSDQLGQIEPNSADQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQNPPLTDSDQLGQIEPNSADQLGQIEPNSTDQLGQIEPNSTDQLGQIELNSTDQNPPLTDSDQLGQIKPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTYQLGQIEPNSTNQLGQIEPNSTDQLGQIEPNSTDQLGQIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU27</accession>
    <name>A0A914HU27_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU27"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4680.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4680.t1"/>
        <property type="gene ID" value="Gr19_v10_g4680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="295"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4680.t1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56099" checksum="52F77A726CF5614B" modified="2023-02-22" version="1">MPISTESINGGEDITTDQEWWPPNFANLDSFEELRLLRARIAQLERQQTINSPISDTFDLLAQNENDAADTLYGQNDEIRSNNDKFKAEKLDQLEEKMKQIELELKGIKLEEYQNNQQQVIIDAFTEKLKVSIDQFSLKHKELLNVHQNLMEEMNLKQQQHQKETNDKIGWLNKDQEQCVSIDQFLLMQSDQKALLDRLEQKQTANAQQQKTDQKALCSTIDQLFNEREEQLNNFLAQFVEGQNKKFEEQKEQSDMDELGNSLKTELEKEMNQLKGELIAKMGEYQQQQQLNIVDLQKAVAVLNNAIGIGLPFQNRWDAAACHDELALIEPDRLTVQVIGKDWGYHSVFAERPIPKRNFGIFYYEVKILTQEGFGHIGLATKQMPLDKCVGCYNGTYSYGSSGKFWGHAVDGCSYCNGRPYTEGKPRGVGDVIGCGVNLASRQIIYTKNGQPLDTANLFVDSDTNLFPCVSLFLSGTKIEANFGPNFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV92</accession>
    <name>A0A914HV92_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HV92"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4802.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4802.t1"/>
        <property type="gene ID" value="Gr19_v10_g4802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4802.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19055" checksum="094ADB0C4C020E17" modified="2023-02-22" version="1">MATSSGDKFDEDVQHHRRHNHHQGRLHQHKRSTKRLRTRPRDFQSECLVGYRERIEFHCRFPNTDKPCLREHADDSARQLDVLATDCCAAGGLCTVDDIEALCCRTMDCLAKCYGPSFTAQIQSRFRYADILLRAHPNAEGRSNKIGRRMKKRGGKEWGEEAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVH5</accession>
    <name>A0A914HVH5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVH5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4364.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4364.t1"/>
        <property type="gene ID" value="Gr19_v10_g4364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4364.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13566" checksum="273A06E8B430C6FD" modified="2023-02-22" version="1">MSARGKGGKAKTGGKAKSRSSRAGLQFPVGRLHRLLRKGRYAERVGAGAPVYLAAVLEYLAAEVLELAGNASRDNKKSRINPRHLQLAVRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTQGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWQ0</accession>
    <name>A0A914HWQ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWQ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g518.t1">
        <property type="protein sequence ID" value="Gr19_v10_g518.t1"/>
        <property type="gene ID" value="Gr19_v10_g518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000035">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038165503" evidence="13">
        <location>
            <begin position="31"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="41"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="258"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="411"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="508"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g518.t1"/>
        </source>
    </evidence>
    <sequence length="639" mass="72473" checksum="6C759E35C3B6982F" modified="2023-02-22" version="1">MLSPTGRRRLLLLLLFLLAVHFQLHRKATARRQKCPGSLSEDKILKEMFHNYTKRLPDSDHKDESVHVEVEMHVQDMGSLNEISADFEIDILFTQLWHDPSLSFVNLSSECVRNITMESRYLKDIWTPNTCIINAKRTSVHASPADNIMFILYENGTIWTNHRLSVKAPCALDLRTFPFDTQTCELLLESYSHNNEEVTLHWMAEPITMMKPIQLPDFDMIQFATKRVSVLYPNGYWDELQARFTFKRRYGFYILQAYVPTYLTIIVSWVAFCMEPKALPARTTVGVSSLLALTLQFGNIHKNLPRVSYVKAMDVWMLGCISFVFGTMIELAIVCYITRRQSMMRTRLARRSSSRGDSLSMYSQHFAHSNRRSFASSCALGDEPSGENTQKKMNCRPEATSFRLLATQRGSRPSSIRLHTLPTRNGTIPSSTNGAQRRRTSNSSNCGIFPLARRRLKRRSEFDRGAQAEDKSPAIFHHTKQNDGIPAMAKVGTGDICIAVPTHTHCAASSPPAQRLPFRSQNGSVPEGIPVDRNASTARTSAGEERHNNSVDKRSTNAISEEMFPFIPSPMPMPSIGRPLRPSISSRWRSFGDEEEENRLIIQPESIDKLSIVVFPLTFTLFNVTANLLVVLPNPRKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWS1</accession>
    <name>A0A914HWS1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g4493.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4493.t1"/>
        <property type="gene ID" value="Gr19_v10_g4493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1251"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1327"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1549"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1619"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1708"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1748"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1814"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1877"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1955"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1266"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1413"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1553"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1619"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1710"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1748"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1827"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1881"/>
            <end position="1900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4493.t1"/>
        </source>
    </evidence>
    <sequence length="2016" mass="216100" checksum="AEC42AFD9CF3FAE6" modified="2023-02-22" version="1">METRSSAAEDDQKQQQQPPPDHPSSMLLLPINGADHINQQQQQQQQQQSSSTTTTTTTAMTLSSSMLLVASGAEQRAQTTATMAISEEDGTPNCTDVEMMSPSFHFPMPSSSYSVPSAAEQPPKSSDHSASTSAAPGGRHSSFEEAETARDSSSSSFGHRRGSALSLGTAPSSSDLIVLDSPTTIFAPRLNGGGGGQFENVASSSSPFVIGSMGLTAMHPNINNNSSITTTAPATASSSSSVPNMLLLQQQQHQQSVVDVDDMFELAEVIGCTGGTSAGGGPPPPTAAPHFGTTEVSDGGTPGNKPVHECTACGKQLCSTRSLKRHRVTCKKVKAQQDDSASSVDGRLATSTSTSVSDSMSTSTCSSSSSSNSSTTTTMSTETATMTMLMTAKKCAEKLSSTKKMSTPAPLLLFSNSSEQQQHRIVIRSNSTDTLQQQHEQQQHLTAQQCLSATVTTKPSSADMMAAHGGSMGSSPIVAFPPIIAPPPPHQQSHHHHFSAITAPSASNKVVGQAAGGRFMALDVAAQQQQQTAGINDGTTGYERLQQFGATQHQRQQQQQQQQQQQQQQQLFYPATVAMLSNNNNNNNNNNNGNSCAAPAAAKATAGVVLLAKHDGDVDDDDDDDDDDDIVVEQRQQKQNVFVAVVPDKDRTAAAAAATKTTMKAAGQQQQQTEPNKVSDVVDSVVAKLRQKSSSNSTQRSTATAVVASVTASNVPSQQSTEKMVHHQQQQQQQFKLAQQQRHMEWAQHQHQLQQQHHHHHQQHHGVSAHSSSCSAMPPTGVADCSSAAAAVGTVDQQQQQQQQQQQQQSSPQVMHIVYSSAAAVPSALTASATASRTSVPSSSLYVASAGGAAVPSSPVVHHHQFQQHFGAGITPQQQQQDFQAVYHQQQQQQLKYKQKQQDNAALVAPRGGVGAVAVQQHQQQQGREAAAAAAVNVMMVDRTEQHHMHMHYQQQQSGAAGGAPPKSAPAISAMPSQQPHFWHNIPPPPQHNEMGKFICSPPPYPGPHQAHGYQMRANNASGGGAGKELFLQSPPAMAPLPPPQHQFVAFDEEQQHEKVKKLSSCPQKKRNAQNGGAVCAGGDTLAAVKSEQTAAAAATASASSTRNVYRYLCPECDKPYSCRKNVKRHRISQHKIPLQEAQDGSIKRIKLTEAELAQKDCAMKAQQAETAAKAGGKDKTGAAAEAEHKLHTTIKEEIDSMESTDHHQFHSSAQSSYQQQLQHQQHSVGTPEAKFVIAAAVTVPPTAGGQPLKSAAISPYEPAHQQQQLQQQQQRMAMFSTGGGPPSSAPPHSAPLLIGGHQSQQFFMATFPPQQQQAQYELHQQPGYGQPQHYPPPSQHAYHQQQQHYQFQRQQQSVVHLQQHAQQKQQHQQQQRVAGGGVGAVAAVAQQNGDFQQQQQQQLGGVEYNAMAQHQQQQQQHYAQQASASPHNHVQLQHQQQHYAQPQQHQQLIEHHAANSSTSFSASAGNFAQLTPMSAPPIIAVTPQQQQQHQQQQQYAMVMMHHGAGGGGVAVPSSTSGLYSSVSSMSAQQQYGAVAGQHQQQQMPGVSQYYQQHQQLQQQQQPQYHQLQRPQPNGDPSYKETLDCWEQIKSGVDTFMSTSDADAVEMARIVEDLKRTEETTEQNHRARIEQQRRQSGGNFFSFGPVPSAAGAGGGGGNEQHHHHQQQHQQQQPDANANMDTTSCMVVAEAGQGGPRKAVELAEADTTFSPPAQSDEATSAASRRLSMSATAAVMQQQQQFVQRTYSASAASAPSNKQQQGGDRVHQHFGVNAEGTLMMRSGGGGGAGGQQQMTMLTQQQQHGGGAFIDHHQQQQQELQFRNVQPQQQQHQQQQQQTMYSSAAAAADDHQHAHHRFQHGDSVAGAVSAAASFYQPSQPTTAKRAPRRSTPAAAAASSMASEKQPPQGTAAAPKGTKKSHKASTNPPAHFCPHCDRGLSSDYSLKRHCQSCPKLLGKESAGGGGKKKGKSKKAAEEQHQIICDPDSTMNESPPADGSKPGTANNPALVMDGGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ06</accession>
    <name>A0A914HZ06_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KAT8 regulatory NSL complex subunit 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ06"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g598.t1">
        <property type="protein sequence ID" value="Gr19_v10_g598.t1"/>
        <property type="gene ID" value="Gr19_v10_g598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056519">
        <property type="entry name" value="KANSL3_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136:SF16">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="TESTIS DEVELOPMENT PROTEIN PRTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23154">
        <property type="entry name" value="KANSL3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANSL3 helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g598.t1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121327" checksum="3EDD0BC1BB0A982B" modified="2023-02-22" version="1">MLDLLYHRVFRSHVNQHTGCTSFGFKLLLFILIITGWRQIKRRKTRIVESQSHESNTRRRPGQMQSNCIYLNSRSPSISSDISFMDDDVNSSFFCDFESDVADADEISQITLREQLNQLRTEDFILQAHFKFATGTLDQQHNNLPSVAYCGDKYFDNFLDEQEEIKLMESPSLVEIPGIATPSYSLVSSPKLGSTEIEISDATNLMESTSPFSQQKEKKQNDSLASDKKRSRRPTMKSDDFVYIPLTKSRMTNSVTGSKIVPKKEKHDENADVEDVSTLSQQKEKTQNASSASDKSIEQRKFEGLPPLTNISALKRRGRPTLKSGDFVYIPLTKSRMPNSVTDYSKVVAKKKRRTKNALIISARSAELNNTEIEMLDGAPILPMEVAASSSQQRENEIIQKESSKSQQRKLVARPSIAKNAVLKRRGRPSLKSNAFIHNSPLTKARITNSVISAKRLELIRRMTQLRHLNPMASALRGACLYEGDYFYRELLVGRSDPCTISEELEIDCVTVHAPGGFDELFVTNPAESCANSINKILLGKRASLNWVHNQEGEDADYPESLNLDEEVRAYLHIFLQFIDNQRLVDLATQGVAGGASMFHSLTMKNANRLRESLRLYSKSCQLLIVEVHDWLLKNLSQTRLISYLNLLRFLKNAGSNLGDYIITSSSEESELERANKCISEFLAQKLYEPPLSSSSKLIECDPIKNVSLVLVYPQINTKTSQHTIRAHETIFRNLLPLAVCCVEKIELNLNVDRPISVEECTWMCVRMIRQRVKEIAKRRQNDHIFLAGWGTACWLNHKAVGKISNVSGILDFAFPTESPCGSRGSVDDQICLTYPATLFVVGEDAHNVRMQALKQLRRNMIADSGLIVIGSANHNMLVSPTVLSIERVSQFIIQKNIVEYVMQFIKQVVTDLGPPKECRQFLKPIKLPDIYEVDPAFFKAKPTTGPQRPRKPAEKKEKDENEDKLRNERKTSGLSQKAPFRHPTQAAVNLPAQLQPAIPTASSKYGTHLYSARHTFNTSLKKTLNRQIPPLLQGKRMPMPSSSSAFQETLREEEEAACGTRSIEVTDEGIDDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0C3</accession>
    <name>A0A914I0C3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0C3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5697.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5697.t2"/>
        <property type="gene ID" value="Gr19_v10_g5697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5697.t2"/>
        </source>
    </evidence>
    <sequence length="435" mass="48790" checksum="2BA3605C935B6E0C" modified="2023-02-22" version="1">MSAADVVDDTSKTEHKSQSQHSDQAESTASSHIPPEIASLSQLSISEPKTEASSSSSTASNKWTLWRYDCRDMPGHKCFTMPCAFCDQVNKLKGVSKGKVTESTDRWESYLKKGKSFEDEQMLTKTLGEFLPSKLAKDVFFNRKLGVGIFRGDIEPKSENAENVDGIVFQLLFLVTSGRKSAALMRKFDEIFLHALRLTFDLPPPIACHVNGIFLRCEMNPGKGLEKEQNPYGNLMDLPIMAKLEIWIGDRSHKESVCTTLISEIRARVDKLEIPLNTFRPFIAINRVQHWTKEAQKCNTTPNFMPNPKSPFKSEAKIVDVAVLLVLCDGKIFTDANDKDLYKEPVQKASLGENAFIFVTSLIVMPALIFGVLMGPKTFKNLSPKYAIKFNITLSSIRCIIYFCYHLDQHATVSPTFGVRRQFVSTAEESSAQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0D8</accession>
    <name>A0A914I0D8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5446.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5446.t1"/>
        <property type="gene ID" value="Gr19_v10_g5446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000114">
        <property type="entry name" value="Calpain a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="101"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5446.t1"/>
        </source>
    </evidence>
    <sequence length="826" mass="92237" checksum="2CA23DECCE471527" modified="2023-02-22" version="1">MSLLGRLVTAVLSSSPDAIKGPPATVGDAALIGPTTSTSLHGKKCQIINANNKIGNCHSVSTRTNADNKNVSSVPVTLITPSKISKRYRQLKRKCVRKGQLFVDTEFPPDNTSLFMADANGDGSAESAAKLEIEWKRPGELVGDPNLFVEGASPCDVTQGILGNCWFVSACSTLTHNAALLQKVIPEAERQEWAPGNDYCGIFQFCFWRFGRWVDVIIDDLLPTKDGQLLFARSKTPNEFWSALLEKAFAKLYGCYETLVGGQLADALIELSGGVAETLNVRKFLNKHHEKFQQHRPISSTLNPNEITVQNGTVVDFTDTVADSNIDGARRLFRMLKYAFARDALIVAAIATTDKEQIELTLDCGLVMGHAYALTAIRYIDLDAVGGAHERGQFRRTRQAMVRLQNPWGMKEWNGPWSDGSPEWEQVTEQQKLRLGITVDEDGEFWMPWQEFVQYFTDICVCQLLTMGTLVECKQQQQQQQAQRGMSMRMKLSVQLSTATVGLTEKRWREWTFSGRWFSNGAKSGAPKNRAGGSAIFPATFCYNPQFAFEVNESDGPAEVMLALCQREDGCAFDGEAMGKRRREPLVVIGMHVLRVELNRRHRIHQTVNPVTSSDYLSVRSIHLHIDGLSPGRYIVMPTTYAPREEADFILRIYSPSQLSPVELRDDVPALSALSLLRCRPQFIVARVRIVDVQLNKLIRFGGSDLFCSLSTSRGGDRTRTMLVQFVPGQSVKFNESFVFHANASRRWLLNVALIEQPKPFQCRNRLLGIGKVELISNNESVQKEVELIGPLQKTLIRGSKGREMAIKAIGKARIEISAYDDPFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0J6</accession>
    <name>A0A914I0J6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0J6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6366.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6366.t1"/>
        <property type="gene ID" value="Gr19_v10_g6366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6366.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17467" checksum="39B1E106E5125BFE" modified="2023-02-22" version="1">MHFSDPYKANGNILLTIEKVSEFARGHDKNSSGRRFSDAVYIRGLPWKIYAIPPTVSAQKHLGFFLQCNSDSGNLAVKQKLGCPHRQKNGQHRRPDQVLSQTGCVDGVDVFAVGIGNIDYLFRDGRLRYVLPNDMLSLFCLSKLQNSQKIATLITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1U1</accession>
    <name>A0A914I1U1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSN12-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1U1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6096.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6096.t1"/>
        <property type="gene ID" value="Gr19_v10_g6096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00835">
        <property type="entry name" value="RanBD_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="202"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="915"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="883"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6096.t1"/>
        </source>
    </evidence>
    <sequence length="1056" mass="114184" checksum="3297401A22B2E5E1" modified="2023-02-22" version="1">MYIFPAQRMMEVEFSNFYASFSYVSSPEERYDDRAAVQWAVFDELVMLHLNVLHALSASDWQAAFGHQTNALQLFNREILQREKDANWFIPILYALCSDLRLVARIADKHGCVLWNGHQRKAADAQTATFYEESASPIMESYRICVAERSDATTKKVAILNLTNQLFRIYFGINRLHLLKPLIRSIDHVGELYERFSLADKITYKYFLGRKAMFDMDLPRAEESLTFAFEHCSAQFMRNKRLILMYLIPVKMFLGHMPTQQLLMRHNLGQFADVVTSVKDGNLRDLNLALQKHQHFFIKCGIFLMLEKLKVITYRNLFKRVASILNTHLIKLDAFLAILRFLGTDIDADELACILANLIAQKKIKGLFCLCYIKMATDNERMFREKLSILNENFLRFLQKAHRSNSSLDFTPSIKDYLKHLRGLDQMYYVDETTDASAVTNAPLTAATTTAANIPLLFGTNATPKTTTTPTTAVFPSFSTLNEGVSLTSTSSTVTTTASTTETSAVPKLIVGATAPVTTTSPSSTLTFGGFGATAPVTTTSPSSTLTFGGVSTTTTTTAANIPLLFGITATPKTTTTTTAAFPSFSTFSAGNFPISSITGSLFGSSTTQTVTSTSSGQLQVNGGSRKRSAAQSVDEISPYGKRAAPTLTTETSVKCPFGTTASMTSTSASSAFTFGGVSTTTTTTAANIPLLFGITATPKTTTTTTAAFPSFSTFSPGNFQTSSITGSLFGGSAINTATTTTISLTSTSSTVTTTASTTETSAVPKPIVGATVPVTTTNSSSTFSFGGFGATAQVTTTSPSSTFSFGGFGATAPVTTTSSSSTFSFGGSPTTTTTTAANIPLLFKSTATTAAFPSFSTFGAGIFPTSSITGSLFGGSAINTANSSPVVGSTEKEAPEKGNGSDDEPTEEFVPTDNFKPIVPLPPKVETKSGEENEEMLFSARCKLFRYKDKQSKERGIGELKLLHNKESGRYRCVIRSGDQLSKLFANFPVLANMKSQATQQKPNIRTLKCKDFSDNSDGVDEVFLLKFRDQTTAEEFAAKLEETVTKLEKSKGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I288</accession>
    <name>A0A914I288_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I288"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6644.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6644.t1"/>
        <property type="gene ID" value="Gr19_v10_g6644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF54">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="9">
        <location>
            <begin position="232"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="10">
        <location>
            <begin position="505"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6644.t1"/>
        </source>
    </evidence>
    <sequence length="710" mass="78067" checksum="7C937E6B3AB43B98" modified="2023-02-22" version="1">MPWDCGLLCLFTERRRHIEVLWRRRLLVTDDERKAKRRFLNLMRGFDTEDLDVLRKAIETGGVNIKQCAPGPPMDLVEEREASSGSSGEEEGEPEMMPGCSTTIVSTRPRHSIKQMERDRILFQRQRFPTVASIQHQPASSSSGGMTMLPPTTPTATTVPISAGTSGAAAVVPLQPPQGIGSSAYQRRYSTHREQQLQQQRNRRDSKFSRRFAVYTTEDNAGNSLRPLTTTIITSAAGTARSPSSSDAELDTEENVPTSTGRRRRHHQQHQRHQRLSVESADIGTAASPARRREVPPLTNPDAGLIPQIDKPMSMPYLCCKMWRWKDLQVDAALHRLDPLPWCRFGRVTINNATVSCCNPFHYGLWIKPETVSTLSDEQSVASGVLVNGGQRQQQYDTTTGSPITATTTILGDTTIGHVRSAFQHSLQAARAASTAYGDANDELPPQTPPPAPPAQATMLVGNSTSDWHHQQMGNHLGGTTMVPSMATTPNRRISHSVHCQAMSWGRMARWQHNERVGDVVTLLGQFAVVGRMAGTVFDGQDVKTAWDVDNAASFALLRQSSDEMSEALDEVWLYNSSDQPLFLCISRNIARAAGSTVNPSAAAQVPNIRRLSPGYCVRVHRISTRPTTMPDHLASSSPLHQHIGNDLSSFGPMIMPSPPPTELMPMLSTAQPNAAALSLLTISVGAGWGANYECRCVTDLPCRYEVIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2B0</accession>
    <name>A0A914I2B0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2B0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10971.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10971.t1"/>
        <property type="gene ID" value="Gr19_v10_g10971"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6847.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6847.t1"/>
        <property type="gene ID" value="Gr19_v10_g6847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10971.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6847.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10544" checksum="8F7FB66621A747BF" modified="2023-02-22" version="1">MMEILLRWSGLIRAHGKVFTGRHLPQINRNRRDGPAHPTFPAPHQNHPTLIRATPAHRRITVARCRLSKPPQCRARYSQHSQISRPINQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2I1</accession>
    <name>A0A914I2I1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2I1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6716.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6716.t1"/>
        <property type="gene ID" value="Gr19_v10_g6716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="464"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6716.t1"/>
        </source>
    </evidence>
    <sequence length="547" mass="61055" checksum="D3C2CBB32346038C" modified="2023-02-22" version="1">MNDWISSDVEPHVQSGAGDSTNLSISDLVTQTAAQVVQEQQNDQFAAYGFHWCDEWGAFYSDDTGYFYDPNSALFFHPNTQLYYVYNTEAGTYDEVGANNAQIPLVKWTKKAFRRRANRLFGDDFVQAARQEDVDVAELTLDLVDRCSFLAGDYCDKRLMKRSMLEEHAVEELGEGVSIKRQFSAAAAARCSTNSESESEDDGLRTLKEEIVRRQQEEEICRNAPCIRMVERPRGLLHIVTICGARVGFGATMDVQIGGGKDDESEQFDKEELLSISYSDGQYRIEWDSQATAAAVHAEKDGHKLEPGSSYSIQHEDLVAIGPPDHRQILLSFHIHNGLNTCQGCEPGLFTARGSGNGEEKSKKRFSRRAEHRRQMRALKEQYGLLEEDDALDELRHKYSDRAARRRREFGIDLPAAVPNSAGGGIYANCSAAPQPGSSTDSVQLQQARKKDSDSPAAVVPINAQNKGFQLLKGMGWTEGQGLGKNSQGIQGPIVTQFKNDRVGLGTTVSTAPKINIRLNERQRNLEQMRKRYEQIEARQQIVDGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2L0</accession>
    <name>A0A914I2L0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">PPPDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2L0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6036.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6036.t1"/>
        <property type="gene ID" value="Gr19_v10_g6036"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6036.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6036.t2"/>
        <property type="gene ID" value="Gr19_v10_g6036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041192758" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6036.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6036.t2"/>
        </source>
    </evidence>
    <sequence length="1056" mass="122274" checksum="085C42CA24AB1398" modified="2023-02-22" version="1">MKSFLIFILFLIFPLGVELKNDADAIKVSSPQNSKPANSNTDGNELDKQMVPKKSNIFGKLSPKKLMSFRKDEQVLHLDLSYSELMFLEAFIVNRIRQFLIRPLVEGRVKITKYKTNTVYQIIDEIYASFPSAEEETKWQNIFGKFTQYLKEKIESYKKEHDEQIAPESVVIFQLYALLMLGESIFNVCLNEYKLNQNAMVGWWRSFRYELPTSKLIDYAPGSGNDQPQLRQPLLQYCIWRRKYYRDNIKSIKKKGSELRKHLAIKVPKDLIQINLHVPEYLTEDGASFNPEAMPDQGENKDAAPIFLALYQLQSYDFIHPSVIVGKLDINNFVRAPENCLEVHYSTGGIRVTKLGDFDPKKLKFIKVLMLKNVTTKFSVRQIELALDYLALNYKKHDDINENCVHFISELINLISAERQNDTYPPETLNYTEYPVIYESDDATFKISNEGEEHRVNWKNNEFLNKLLHILCTCSTMQLRAHWVTRGVERAQLKPLTVKCLRPQLKIVEGAHGCEQRAPGVLGGSYQLGGRQAFNSELLCPWMSSDSSFLQPFAHFFAATIMKSFLIFILFLVLPLGVELKNDADAIKVSSPQNSKAANSNTDGNELDKQMVPKQSNIFAKFPKRLMSFRKSHQQDEDVLHFDLSYSELMFLEAFIVNTIRQFLIRPLVEGRVQITKYKTNTVYQIIDAIYTNFRTKEGTKLKNIFNKFTQYLKEKTESYKKEHDAQIAPESVVFFQFDALLMLGESIFNVCLNEYKLNQNAMVGWWLSFRYELSTSKLINYAPESGNDQPQLRQPLLQYCIWRRKYYRDNIQCIKKKGSELRKYFAIKVPKHLIQINLHVPEYLTENGASFNPEDMPDQGENQDAAPIFLALYQLQSYDVIHPSVIVGKLDINNFDNAPENCLEVHYSTGGIRVTKLGDFGDPKKLKFIKVLRLKNVTTKFSVRQIESVLDYLALNYKKYDDINENCVHFISELINLISAERQNGTYPPETLNYTEYPVIYGRYAKTFNLSDEGKEHSVNWENNEFLKLPKIIVISKKLPKAAQSVVRQLTNLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I317</accession>
    <name>A0A914I317_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I317"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10962.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10962.t1"/>
        <property type="gene ID" value="Gr19_v10_g10962"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6856.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6856.t1"/>
        <property type="gene ID" value="Gr19_v10_g6856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275839" evidence="2">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10962.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6856.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46801" checksum="0360D5D45373AC06" modified="2023-02-22" version="1">MYHHYLLLVLLALVGGCVADADVYWVRVYLTPSLYDDHHFYYVQATCSSNKELKTNAFSVSREKNLANLKVGIKSARCPDKYQIAVAIIYNNDKKNLDDDQKLEWSAWTAPNTSQTDTFKEDIISIDYHIKFGNYFKLDILPNLAETFNSKMVYRVNVYCAGKERVEFKTYTQSKTMVVFNTALSKCDNYDVKVWPIRKEWKKIENTFGEPVLAHEGIRVKNGATYQINFANYFNLAIGPPLTPNSGQVYYAEVKCHGREADTFRTYTEDDAQIVLNAFECTEYDIFVWKLDNQMVINAEKLFPIEEQKPSNEFAVIIENDGTYQFNYIEEHSVEIDDVHSMDIEDGGVQEQPLKKKLKQMSKDIKELFEKTANIKRDVEGIKNELSTTMSELTEFLKQNFNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I386</accession>
    <name>A0A914I386_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I386"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g62.t1">
        <property type="protein sequence ID" value="Gr19_v10_g62.t1"/>
        <property type="gene ID" value="Gr19_v10_g62"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF310">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g62.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="29076" checksum="EBB13528D08265D7" modified="2023-02-22" version="1">MNFAFKSKMADFDKHAAQREAESLRTLAFFGVCLSTVATVIAVMSVPFAYQHFQQIGSQMQNDVDFCKLRSGNMWREVTRTQAFSKVLHEGRHKRQASSCCGCGVSPPGPPGPPGQAGQPGGDGQPGGAGQPGAPAVAPPRQYPSGGGCVPQCEAAQPGQPGPQGPPGQNGQPGHPGESAPPAGRGPPGQPGAPGPDGQPGGPGEAGKPGAPGQLTQGPPVVGPPGPQGPSGQPGSPGEPGQPGQPGNPGGQGPPGDGGAPGGPGNPGGNGEPGHPGGQGAVGQCDHCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I393</accession>
    <name>A0A914I393_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I393"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6427.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6427.t1"/>
        <property type="gene ID" value="Gr19_v10_g6427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6427.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28536" checksum="A58CE18810136BF1" modified="2023-02-22" version="1">MPRNTWKHQIEQRIDELENRSLSQERQLRDLRCLALHAFHRLERVESWASRENWRPFRPRYAPYIGPLTVCAREQQRRQRVNGAIVADHHQLQQHACRCTICLRHRRVEDRLASGEAAVSAQRQQIQAEQNHLEAGTSHNNNASNNNNSSGSNAGPSQNRNEGSNNNNNNNGNLSLDEQFDPCGCHQWQCEACEEARRMNRLRSRTGRPHGPRTASEGLMLRDRREEQAEQSLIIIQLFFSLSFSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4H0</accession>
    <name>A0A914I4H0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4H0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7430.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7430.t1"/>
        <property type="gene ID" value="Gr19_v10_g7430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF9">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="108"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="9">
        <location>
            <begin position="321"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="11">
        <location>
            <begin position="508"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7430.t1"/>
        </source>
    </evidence>
    <sequence length="638" mass="70895" checksum="ECE4C6D6D25A37F5" modified="2023-02-22" version="1">MTSSMSVSKGSRFACLFSTASDEVPTAPSTRPTADELAEFVKQIPIEKRSLTRGMSVNKFEKDFIIYPEYEHSVEQQRIKKIVQNLEEDLLIAYDQLKTDTATTTAQKPGTLPAKVQAILAKHKVSAAAVPAEFGGLNFCQKDLVQLSECLGSQDLNLLSTFGTMSLAVSLIVQFGTTAQKEHYLPGIASGKWRPAVCIQDETTGPQSLEHVFSAKGQQQFLSVIKKNVENALDANLFIVFANRRVGELVIPACYLIERDWVKDDEVISGIKIRDQLKTGGLQRCNFSTVVFENVPLRDYMLLGSTDNAGYSADELSIEGKIAYGAGVVGHLKKMIGDLCHFANQEIKGNLRLADSHPIQRSLTELGIITYVLESVVYYIAGLVDEELFLLQDIENAIVQRLCNRALRQSITTIAEVSGFAGINTELGYEQAMRDTIAMLALSEPELHLIRRISIPSIETYVNKFGGMAKFRDALTSQKLFKIKYGKINEQDFLNPKLIHFIAEHIHPSLEPCAHSLEFSMTRLGQLFDKVATHQGALVNTNYVTLGNICIVMENLLAMTATIARSSRSYAIGLRGADNEVDWTTMFCTKAAEESKNIILDTLSAESFVRMNPRLTDVGEWMLQYNGYFPEGPLEKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5T0</accession>
    <name>A0A914I5T0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g6882.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6882.t2"/>
        <property type="gene ID" value="Gr19_v10_g6882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF224">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="3621"/>
            <end position="3643"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="50"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="373"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="670"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="725"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2249"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2352"/>
            <end position="2391"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2393"/>
            <end position="2435"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2443"/>
            <end position="2482"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2484"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2560"/>
            <end position="2594"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2598"/>
            <end position="2640"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2642"/>
            <end position="2684"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2686"/>
            <end position="2726"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2728"/>
            <end position="2767"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="3014"/>
            <end position="3102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3704"/>
            <end position="3748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3908"/>
            <end position="3962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3713"/>
            <end position="3723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3726"/>
            <end position="3740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3934"/>
            <end position="3950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="3953"/>
            <end position="3962"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2276"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2362"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2381"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2425"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2453"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2472"/>
            <end position="2481"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2516"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2584"/>
            <end position="2593"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2630"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2738"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2757"/>
            <end position="2766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6882.t2"/>
        </source>
    </evidence>
    <sequence length="3962" mass="435233" checksum="D268BB77453F6C15" modified="2023-02-22" version="1">MISNKTFKHLAPFLCQILYQTFGIFAEEFPYSIGDLHTFCPDSKDFWHSVGVNCFKMTPIDQRMDWAEANAFCDLSINNHSDALHLDNWLLHRDLSRKFLLQRAQNGQNEFWTAWYIEVRQKKLPEIIHRYGSSQNSSIYNPAWASLEPHLANSESGRWCISWGAALLDETNFGWHLRNCTDQLPVICQTFACYLDGAGLPQHRCADNSACISRRALCDGVSDCESGDDELAQNCDNIAAQKCDDIEEIFTKLSSNSYGDIFPIGWQIPVTKFKPKTCLAKREKWLIDQKPGARIKLDFLALQLGPNNRLSLRDLDTGEHFLIRQSDDKFPSILGANRLEILYERFETQNGDENVAERRGFHLHYAVDDANVCTRTFESWNGSFVVPMNVPDTGRYRTPMQCQWTIENRNRGIVVVKFPVFRLSPGDWLGLVLDEHSAHVGHNFSSSMPAPSVLVTNAPRIQFVFSANNSSAGDAGFRAVFQRSCTDQLISSSPSGNVQISLKKAIADGPVNCSMRIEASKNGPFSLFIDYLNASENDKIYFLNSDGHGLDNKSFVGIAKEFRSFTSAVLLNFVLNSSSLEANIAYSIDCDRPRLWHSAHQMAPNSNMNNSLSKKFERLVQNYLPFRYRIPSVPCHNSKGNKSAELICADGGNLVMSGCSEDGNSAVPTHICIVPRIKNGHATELNRQLGILRYRCNSGFASMQAQQSICTKSGQWIPEPKCSEIRCADPAPNVMPNLAFFHPPDRYEPAKLDYRTLSNRFGNLITYKCGNGTMPRGRRSMAQCSANGTWTTVEIACKKIGCYAMNVELGNFSHFWTLPGAVARIECAHGTKLATQNLPKCILDGNGMAQWEGIPAQGIKCQFENLCKRFGQNPCGPTGICIALNGTYSCNCTSPTHRFNKSASFGEQCQALDECAEGRWPCSSGTCNTTSHPLGRYKCVCPPGTHFLYDTKNKTKNNLIIPATQWLIPGHSCIILRCPTIRPLSQLFVVHSSQPQHPVNSTLVVYCRHNANSALIGPETELKCLPNGQWNGTMPTRCQKAEPFCQAPLMPNVATRIRGQKFAEYVVNSVVEFGCVQWTHNRQKGSDFLMVGYNRSICLATGNWTNAPPTCILPQCSKIALGIRNDGMHISLTSGQKWPTNELFGPGAEVKINCAKSGKNWTMICKRKANFEMVWSMDEMPKCEVNTEEVAVVGTCDMTKLAKISRDLLIASRDSVLVGQEVFFKCAQPNYTLSDQKARKCVKNSGKRAARAAVDEQLPVGDLPTGDQWHELIKTAMPESDVIFDSVHRLYGWQKSNHWTQNVANGSWIYWPSHHGKSSLITPSMEVSAGDWLSVSVELGPLPCSNCMVWISYFAADQSSSAFPVEHFNSLGAIMADPVIHSIQFFSPHPKLRIQISADDKSPNFLVERVKLISTACPALNLSPVTNFPRTPAHFENQTISAQCQLGKTLRLICSPLGQWLLPENEPLAYGCGCQPPLALNSHGKCGIKEALLCHVCSSDTDTACFSPTGAEDADVARATAATITKRCTSPDELCMSQSRAHRAHGTQVPFNIVRRCAERAECGIFKRNVSARESCRTDLDGVETCTICCSDDLCNGARPRQLLNGGGLVAVKSLMALSSSTTTTTTITTTLSTPTSSVLQKVTTPVITSSSSTTTTSPSSTITTITLPTRTAQTTTTTQQIPIATTRPSSTSITTMPSSHFVLREKQNSDEFELNSAPPICVDQQPLDLRCLAQIRIRHRMDNGQPEPTVIPWPNVIDNDPHFHLQPMNINISKPHTFMGDEKEIIWRAVDLHGVVKICVTKLVFDGTSSTNERQDLPKGIDIECPDWHIREVNVSAEFGGDPLTDGPPMIRAKYPPIATKKPDELSFDPPVGTHLALGAPKLVFVRLNGIQKCQFWYQTLSIDCPLWTLGAGNWRKFECINELNGLMRCKRNQPCPGGREYPRGMRELRCWRNRPGHGLTYTTDQKSGENEEISLIGEAQCLPEASSLVVMLSIVVASDNANCTKLMARQMNSFLAQNCPGIQWSSSSTNADLAHSNLTGHNFGTETTDGGNDQSVVLCIQRVSSSSRLGRPTFSGHLDMPIVEGQQCPDGSVQTRHFSYHLQCPNGWAPNELLRCEMCPKGHFSSNGTCAQCPAGTFALRAGMTKCTSCPEGTSTVGNGTVADFQCLTRCAPGTFSSNNGLAPCRACPTGKCQQFGKSQKLAESLANSEMPQHFDCTLTGCSGHGKCQNGICQCDLGFVGPDCSILLDLCSAQFCLNLAKCVFDSSNGSSCICSRGFFGQRCEHSAHSNRLTTTDVKHLSTTSSKMQNGICKESNEINECPNGFCLGGFCQCNAAFVKSTNENGQICVPINACLATKPCQKGATDCLHDSNGNVQCVCGEAWAGELCEQQSQSCFLPQNQCLNGADCAWEIKNSTLSTRCLCPVGFNGERCEHQNDQSDLLEQCQHEHRCGTNGSCQLNNSIGILFCRCDRGYFGEFCEAELNPCSSASTSPLICYNGGICQPMTSEKAVCQCPQGWTGGYCIGAHRGSAHCSCPEGYGGDSCQVELSPCTKWPEGDAGICGNGHCLAKGNGHNAKFECLCSNGWTGPNCNIPLGAKECEKTTNKCKNNGTCVPLIDNGIQKWTCECSDGFWGNRCEKRVNYCALNGICLNNGRCKSVVGGDNHYQCECDGKNGFFGQNCEQTAKPCDRNPCANGGKCSPNYADPTGFKCECGPNYVPETNCTRKLNPCHWPNYCNGGQCELLPNSTDSPHCICPPDSMGIRCETRKLSHYDLHFLPFLNSSSSIIQKIRSPSFSCLAITQQSFSLCFWLRFGQTDGQTNKAFPMDLSRIIYISVNELNSADIKNAQRILQFDQFGVNIFDTKLQFDYGHALISHLWHHVCLTFDTAIFRLFLNGHFVDARSGKNFSKNHSKNFCQLLLGEHIGEEAAHFVGQLSQVELYSKRFDDAQIVRMAWNCREWTHRQEKTFSIVEWAHFTTVDVFNKAQIALFPGICSESDCQPGSESDCGHGKNLKTPPEVLFCPRSQFITVPVPNQRLIQIQWEGSLEKMFRPTGTSPIVRFESNFRPGQTFGWGQFHVVYLAEDALGNWATCEFDIVVSPTKCSDLFVPGTFNKLTVHQFRVEEARQAEKSINLKCLSTELVSNVVAKPPFYTCDRLGQWDRWANFGRPFTLPSCTPTENAMQEVVGDLHFDATCDEAANYVLKVVETIENASKNAGAFCERPQCAGQLGIKTECHGEGNGGAVDNNDPDVPSLLSGAGNRVRRVPPTGQQQQTAVRVLFDLSVNNSKRAVAPVIRDAMEAKFGSNFVGETTRLQCSNAFPQLHINGDAKIAGSASVAMASDPPLVQCATCAPGETWQQIVRKIATTTKDESVVNSDMSGSCVKCPANSYKSSPGVQPCTPCQDDRITGGVVGCMREIDCYLNCPPGSVYCSMTDTCTMCAHGQYMPYSGRLQCIGCPPGTTTEQEGSTSADQCSVRCALGEELGAGEQCEMCTRGTFRAEGMHACRHCSLGFTTRSSGAKSASDCAHIFCPPGHFRNTTIGPDHSDNQLISSLASVCVPCAIGYYQECDQANDGTCKPDEPEPCPDGMECVQTRGQTYECHNLPNINRTDHGDVWRRVWIPMILALFAVLALAVLSIIFIKNRQKWLLMLNRHCPCTFLLCCKKMTVDNLASNEYTRTSPPIVTEISQNVQQQTVVELTAASNENSRSSNTEKSKAHGHDIVASLRPRSASESASSRSNEKVDDPLNEIRSGLMEVMNATELDDGDESNGSSSSHRLTETFGRGQQYFMPTSSRRPQLTVQTRFPITPNENDTIAHHQQTFHRRFRRSFSSSSSSSAVDEPPLVRAVPIHHRDGRSFLGSARATDAIGMRNFSMGEEHNEDGTHTLRRPGGVLVGLRCRQFEPGAGVAGGSVPLRSSLTGRSPLASPAGKSGTSSSGVVPAEQTTAVPSYDDDDDAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6H9</accession>
    <name>A0A914I6H9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6H9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7071.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7071.t1"/>
        <property type="gene ID" value="Gr19_v10_g7071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF191">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037656078" description="Sodium/hydrogen exchanger" evidence="14">
        <location>
            <begin position="26"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="15">
        <location>
            <begin position="98"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="647"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7071.t1"/>
        </source>
    </evidence>
    <sequence length="701" mass="76266" checksum="A168BAFA66D0DA38" modified="2023-02-22" version="1">MLMRLRCSPALLLLLTFLFLPRLSSVHSELEPSNAGALNSDDPAAKNLASADANNSTSSNSSKIPIFGDPQDEQTTQVEEKKDSLAIFFILFVIVLAILLVHLLIKFKLNYLPESLAIVLLGVFIGFALTYSKWDWREVEQFNPNFFFLVLLPPIIFESGYNLHKGNFFANIVPILLLSIVGTAISALVMGFCLYAFGQAGLIYELNAIQSFAFGSMISAVDPLITLAIFQALKVEVQLYMLAFGESMLNDAVAIVLATTAQELSSPDVVAMSSFAMVQYAFLRFLVMFFASAALGALIGLISALLFKHIDLRRTPSLELALLLVFAYLPYGLAESISLSGIMAILFCAIVMSQYTHFSISPITQITFQQTFRTISFVAETCTFAYLGLSLFTIKLVFHPMFLIFSIILLFASRAASVFPLSDLVNRFSKTKISMKNQIIIWFSGMRGAVALALALHMDWGTDENKGVILTSTLFIILFTIIFMGGSALPLIKILTEMFPDEQSSKLVKQRRRARRAARGKTNGIVANGGGSAGALGNGAVPGSSQRRSSPVILSKTQEMVIFDNSEHFTDCEDAGNNDVSRSGASGVGGANSGGRRVNTMPDRKNILSALNENFVRPFFVRKFTPQEKLENNKKLRHIAFEAMKHEGGGLGSSSNGIRMGGGGTTSGAAETSSDDEVYFQSSSSTLNVANSEPAQPLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6W6</accession>
    <name>A0A914I6W6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6W6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8058.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8058.t2"/>
        <property type="gene ID" value="Gr19_v10_g8058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037493874" evidence="2">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8058.t2"/>
        </source>
    </evidence>
    <sequence length="169" mass="18168" checksum="F3612004C677C14C" modified="2023-02-22" version="1">MWAAMFAARLLRGALMCADSWRKCLVDLADEAACNSPAPDFSTVSKAQIGTGLLFAEGVPFVNVTTDKLCKELVDSYCPCKWASCVQREGYAKTNCCPDQFDLVCCATKAVSMQELIIAEKLASATEPTTTTTIGTKKGAASSAVPSFAAALLIGCFYMFPNIYWTMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8K7</accession>
    <name>A0A914I8K7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914I8K7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7903.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7903.t2"/>
        <property type="gene ID" value="Gr19_v10_g7903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038164224" description="Metalloendopeptidase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="572"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7903.t2"/>
        </source>
    </evidence>
    <sequence length="1051" mass="120218" checksum="B64221039087CCE7" modified="2023-02-22" version="1">MILLKLGLLLIALKACGVHVNEPPDKIWNMCENELFSLDENCQSHLICYQSKLAKDSGNWKAANRFRVNSPNASIAYECAGNDGTKGWHAVRINQDITGMMPLESSFGSKSLSNVSKHPEINIIKELTSGGQSAGEEYQNALRYGAYMIDFDVMPFQIAAMEIRQSIGKKDAKLCKTKCAAKWETLKEMEPQTGTAKDSSTLSPVMPKAQHVDHFGTNWMQIEFPMDIQKFSLNISISPYLIACAAHQRNNKADHIQDNYTKVSEVANKDQFNACSKVPTTSVCNKSLELYACYKSINNQTHMNKEIAETCQKRLSQAPFVAGFRVRICMHRDAKKQILAFESRLEFSSSHQHVAGIRFKFGEVSKLLRYVPFSFTELGQQPSEIHAESIKGTVLNSIVNEQINGNWSKVIHFISPLNEALRIFIQIKPEFTKLITSKTNLRPYQDNPDIIHPSRCDILGDNCEPIRETLKKVDEMQEWCAPYNPTEICISPGRTPTPEDLKPFMRPPWDNMSFPSTKMSSNDTLTKDPLEAGDVLYTKDQAQGQHDYYVEMCAKCRNSSKLDKKPRRQKRQHMRGVRIWTKFPIPIRFDTVSLGDQISFAIATISRGVAWIMEKTCVDFTFDKTNDTKGIQIVDNGKRDRCGDSFMALNHETSMRPLMYTGVHELLHALGLQHEHQRRDAYSYIKLNPFDKENAQWTANYGFPYDYGSIMHYPPMISDHNSYDKITLNRFYQQTIGQTEKPSFKDLAIINYMYCRHKCDAENLCQNGGYPNPRLCTECFCPEGYGGNHCEELQENVECKNKMDGIRELDADWQTRTLDTEIFYGKKLRIQLKRLEIESQCSHMPCHKSFIEINFRKDKRARGARLCCPEAIAQVSPSQNWIEAEGPGTDIIISARLRYSRGPVKFELTYETDGGTILPSDLCPDPRGLFSQERNPGRSVACVDNMDKPTKEIPCSQRQTFYSCLTPNHYITVNGHQTNKTRILLECFKREDNPTSYWGYWENKNQDPIHIDDMQCVKYIKPKLFKRAEVEEAFENANGTIGYMVFKYDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I966</accession>
    <name>A0A914I966_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon-related developmental regulator 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I966"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8431.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8431.t1"/>
        <property type="gene ID" value="Gr19_v10_g8431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006921">
        <property type="entry name" value="Interferon-rel_develop_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04836">
        <property type="entry name" value="IFRD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="4">
        <location>
            <begin position="59"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon-related developmental regulator C-terminal" evidence="3">
        <location>
            <begin position="388"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8431.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="49177" checksum="CA81826F0DCBF325" modified="2023-02-22" version="1">MGKKRNTNKVTLALPSSAPSAATAKAGGGSVCGRERLELLSDMDEVESVHSSMTGAAADIGGGESDDENIESVAMVDSFGDQVENALDKRVSIRTKAMDNILLVLHKHCIPDNVLKWRCPIAEIIEKNLKRTSEEAVRACSLAALISLQLGVDIEDEMCAVLEVMRQICADGSAGEAVRASCAQAIGICVYLSVESRGHRFAALQTLKNVWVGMKPTGTDGTSLFSSAIASWALLLERFEPSFITAAIDEVQPKMCAFLESTTVEARISAGEALATVFEIAVKSLGDDFRFRNHAELARLLGELALDSSKQRAKRDKKLQRMTFRQLNDVLAVDGSTLTTALAQQHQQQQHHRPCRPVLLTTGCHAKLLYDAMCQLLQSDLNRHLTSNEVLRELFDLGPVLNEDEPQKLTKAQKSERLSQFGEQQKQRNISRSKGRSKKMGGKHDFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9G3</accession>
    <name>A0A914I9G3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9G3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8515.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8515.t1"/>
        <property type="gene ID" value="Gr19_v10_g8515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8515.t1"/>
        </source>
    </evidence>
    <sequence length="611" mass="66447" checksum="1A300F04712CD8DE" modified="2023-02-22" version="1">MSSGTQMSSGTQMSSGAQMYSEAPNVLGGPKCPRGPQMSSGAPNVLGGPKCPRGPQMSSGAPDLLGALQGQGAAQELLEAQQRMLRVLAAENDELEAENKGKDLIIEALSRENKALVKRLSGEEPRQAKRQKRGEAKAIGIDLGTTCSCVAVLKRRGVQIINNNRGNRTTPSCVAFTDTERLIGDAAKNQVAINVSNTVFDAKQLIGRNFNDEQVQSDMTHWQFKVVRADGGSARVQVKVRGEDVTFSPEYVSSLVLFEMKQAAESFLERPVKDAVVAVPAYFNDSQREATKNAVSLAGLNVLSTINEAEAAAIAYGLDKKGLDKRHVLIFDHGGGTLDVSILTAEDGLFEERSTASDRHLGGNAFDNLLVNHYVADFNSENNQDLSSSSNPRELRLLRTVCERAKCVLSKNTATTISIDRDRFHFYRIVTRARFEELCKDLFIRITDLVENALRDAKVDKAKIDNILLVGCSTRMPKVQKLLSDFFPGKLLDKSINPDEVVALGAALRAAAILSGDKSGIKVPDDRVAAKKALESYCSKIEQSMEDANWDTIVAADKKKVLDKYQEALSWLDGNPAAEKEQFTHQLEELEAVCNPIVNILTTSTSTSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9T6</accession>
    <name>A0A914I9T6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-myc promoter-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g8013.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8013.t1"/>
        <property type="gene ID" value="Gr19_v10_g8013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MABP" evidence="5">
        <location>
            <begin position="53"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="202"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="887"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="984"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1398"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1398"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8013.t1"/>
        </source>
    </evidence>
    <sequence length="1536" mass="172818" checksum="FDD6F3D867DE5549" modified="2023-02-22" version="1">MNSDDSEDKRRLFEYFIVAGLNDESGCPKELSSMSTAQPSSADVGKQTHHYQLAPITDICVIFTSSGETTPPDFERIETTPQGYPADLNHGSLRSPAAFVCYKRGYHKPPLIDLGVLDEGKGEKPMVDAVILDKTPYGLSANISNSSSSLFFTTRRAKADSPPHQLVITQICVILENKGERPPHTFYKIPKNLNKSMIGSEVYVCYKKSQLACKRIAYEPAVLDCFPRVQNIEASLLVRNVPMFFLPMGALIEAWPERCKNTEHHARTVSTCVFTDEAYTKYYGASITFYEPYTKPLSEQQLEKLDLGVGGGEEQPSNNNSSSTAAGQQQQDKIDDPTSRLAAKKDQKNTFYYCNKAICIVSRYPFFEPFRSILFFLLNTAASNSASRIPIERYISHLMYEVPFPSPARPRILVELGTDMIAFESSDDSQTPLTGANFVETLKNLGTDNLLYAMLLTLLEQKLLVHSLRPWLLTCVSETLCALMFPFSWNLPYIPQCPLPLAGIFHAPLSFMAGVDSRYFDLYEEPPSDVTCFDLDTATISQSAVRKLYQLSMLPKKPLKRLRATLDAISTKIGEKLAKKNSMDYEQTHTRIMQSEQAIREAFLRFICCLMDGYTDFLCPIMESPWAEGATDVRNLFDWEQFIQSRDKNAVEFYGKFRETTCFNRFIEERSGAIGGVEPNEPKEEEAHDENCRVPMVEDKSVFYVFFDDCIAKLRAEAVNAVLVKDKNMQNAIPPRLLLDADSMMANRTVVVPAPHVHSGEKREFNYVSFPQHFEAALFETEFITRSLLNRPMQQRNDGGTSLATSRRPKFFLLRTRQEVRKALNDAALLQQQNVAYWPRSVLFFAYTLWFMQLPALLAVAKNKRKMLLLGVRVLSRMEQIGVPFHDQVCYRLLMHLCGAYGRPEMAIIILRKMLNIGIIPNAITYKVYHKALIQSDWPSEPRLSAIAAWRRVQLRLEICSRFRLMLPNSSNILPSTVHKQDITTMSTTNTTAEEEEEDDESRDSSNIVQEIVPMKLIENDETAAVVECQTTALTNHINNNNNNNIAANRTTSNLLDPLGATALTNTVDGGDGSQKLRMPPPKPPRQQLQQWLMSTPTKPSAAAAAVPNNFRLLMSPSREKFIRDHSASPLFAREDEESEAGKNGGKTVEKRRRKSLRLGSSWLKSLANTSLNLINRSQTTENLDSISRDGSIISDARSPSTSSAANGGSPSFLSLANKMRKRAMRTYNEVLGDGVNELLERSGLNNPAQMFKEAKLNLSRSFRADQSGLSMVSSSDDNLFAKDQSGTMDLFYLCAQRTRDPVSIHYWMGDILPEDDSELKNVWLRHNADSTISQEEYLDVLVCSTSPCSNCDQLIYDDDLTIGWAVDDANLNAKCPQCQHTFLPSLKVCVQTRKQQQRTTNETNAMNDSTSETLGTPTTRDASGESASIPPLDVEKIVQSFTVPYISPLVLRRELETLVTSSADGALVLARPGMRIAHPIIFWNLFYYCRRLDLPTHLLTWVAEAVVIHCVQDMPRLPSATEQQPQQQVHSYAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA70</accession>
    <name>A0A914IA70_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA70"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8107.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8107.t1"/>
        <property type="gene ID" value="Gr19_v10_g8107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8107.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="26859" checksum="EBE5CDC1740A82C7" modified="2023-02-22" version="1">MLEHTKEEFLSSDGQQQEVLLSWVGCSSSLFLLSQFNLHIWRGCDGTTEWNIVRVEERTNGCERRRCGVCWRGKKRTPSLPMLKLTSDEANHSVIHSSIVRLFAARDLRSLNLSLKRGSVIIFGGKNFPNGRTSPTARVGRTSPTARVGRNHRKNVPNSSGGKNVPNSSGGKNVISSATTTASLQRISTEGGRDPLQPSHSSSSSTFGIRLRIHTSSAKDALHFGRSPPPPPLHKYAPLQPASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA83</accession>
    <name>A0A914IA83_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ras family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IA83"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8332.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8332.t1"/>
        <property type="gene ID" value="Gr19_v10_g8332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048846">
        <property type="term" value="P:axon extension involved in axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033563">
        <property type="term" value="P:dorsal/ventral axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="16">
        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="15">
        <location>
            <begin position="295"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8332.t1"/>
        </source>
    </evidence>
    <sequence length="610" mass="68300" checksum="0E216CDEDA53B3A3" modified="2023-02-22" version="1">MRPPNFEQDLISMIRRAKMKFEARTKDDLLIALNNFIDLQPDVVNFVFPDGMPKYCLSFSGTIPILYKGAVYNIPIAIYFLENHPNIGPYCYVKPTPFCSRSSHLNSKINVLSIPSGSGSNPPYPTSGLPYPTVDPPSHVMPQPSYTAMPQPGGYQPPYPNSYPSDPVSYPTSVSPQPESVYPYGTGTIQPTHIRASLLSAVEDRIRQRLRDKIGTPFAELQSVDVNHQELCTGKQILRNMLDSITRDQQELERILEIYTDKKKELEGALKVVNSSGTAANGTSFNVEDAIDAQTIVHRQIFKGHVQDCAIDDTIYHLGTALHRGAINLQMYLKYVRQLSKQQFQHRLLMYKCRERSRLSVPVSGGGRDRNIGDARGIKMFTHTPPPRGYGPALSFYDEISLVLTQSTNLNVNQPFFSSFPTIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGRPINLGLWDTAGQEDYDRLRPLSYPQTDCFLLCFSLVNPASFENIRAKWYPEVSHHCPRTPIILVGTKLDLREDPKTLDKLRERRLAPISVAQGHQMAKEIKATKYLECSALTQVGLKQVFDEAIRAVLCPQQVKQKKSCAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB52</accession>
    <name>A0A914IB52_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB52"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9210.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9210.t1"/>
        <property type="gene ID" value="Gr19_v10_g9210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9210.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8761" checksum="C0ED743C41191D59" modified="2023-02-22" version="1">MHVFWGKNKAVYRPANSEHAMTEQVVGRDGGRRKKSDERHWGASARGPAERARARPPAGSRADFFRSPESRPTYWPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBD7</accession>
    <name>A0A914IBD7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914IBD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8644.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8644.t1"/>
        <property type="gene ID" value="Gr19_v10_g8644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="94"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8644.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38998" checksum="222CA9D624E262A2" modified="2023-02-22" version="1">MLKLTRIFFTAIPTSSDLVGSRITTSKQWRHQQQLRLCSTNPPSVGPASPLNCPPSVGALRDDQQNEEDDNNNKQRPLVNLARSGIAKEFSGTTAEFFEQQRQAGHNVFGDDACFIASHKSTYVAGVADGVGGWRRHGIDPSKFSSQLMKNCAEIVQSGIFLTDRPDLIISRAFTRLKIRPRPVGSSTACVLVVHERTLYAANLGDSGYLIYREGKVVFRSPEQTHYFNAPYQLTVLPERFKSPTYKGKAEYIGDPPENTDLRQHKLNAGDLVLIASDGLWDNVPEDKIADLLCGVEPNEASLQARCNTLALVARHFAADEHYDSPFALRAKLHGISAPGGKPDDVTIVLFHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICK3</accession>
    <name>A0A914ICK3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICK3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8643.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8643.t1"/>
        <property type="gene ID" value="Gr19_v10_g8643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="232"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="524"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="391"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8643.t1"/>
        </source>
    </evidence>
    <sequence length="593" mass="63739" checksum="D928243038D3B685" modified="2023-02-22" version="1">MGEANGRNEAVGGDGRRRLLGTGDLSALDVSALQQHKPIITQMSRSRSRSRSPIRRSGDRFRSDRGGDRVGASRIDHKSDRMVYLTNLPWELSWMELKDIIREKAGEVNFVEVLEGRDGRSKGCAVVEFKRRDGAIKCVENMHRSELKDRLIIAKEIRDPIAFFRKVKEDTGIDFLGGGDRLERSRAPASRGGGGGGGGGGGGGGVSINENETFGLSPSFLRQLGISTPLCNRVFLTNISYNCGVGRLFEICSLAGRITWMDLQLDKEGKSKGMAVCEYSHPIEAVQAVSMLNNQRLFDRSISVRMDRYPKDVERREGGLPFGLRAVGMGLGANGAPLTDVASVISSINPAHQQPGMNGTAGAPINPFQSPPNVNPFGPVSNVPVAVPQPIQSVPAAPPSGFQQSTPDHGMGAHFQSPPQSAYQPQATGGFFNPPQPTRQDRPSSSIHFGGGGGTSQYAPPKQMNIVGGGASTAVFGQPTQQQQTPKFEHKVEPKYDIGAFAGYASGAAQPMSGGGSDNYQASRIILIKNLPVDYTWQIVSDRVQQFGDLESVEMITPGVAKVRFVKLRDAEHAKAALQGSTVEGRAIGIEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICU5</accession>
    <name>A0A914ICU5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A914ICU5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8715.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8715.t1"/>
        <property type="gene ID" value="Gr19_v10_g8715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="597"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8715.t1"/>
        </source>
    </evidence>
    <sequence length="656" mass="74112" checksum="2894531E156ACC4C" modified="2023-02-22" version="1">MDHTPWRVIAQVIDDVRVFVNRRFDHLEQWQIILYTMSFILFVQWVRKLLKFEEFVSLRQLWGDMLLSFSSYKQKWEKDKEIAYKELEDRIHRADRLKEFYKYLPDRGLPPDDIIREATAYKTMSDILFERGRLCGSLFAIEDDDSNYQRLIRQVFELYSHSNATFPEACPAIRKMEAECIRILCSLFHGGAKSCGVITTSGSESVILACLAYRNFANKNGIRRPEIIVASNAHVAFFKAAKMLGMRVVRIQTNSKSVVNIGALKRAIGRETCLIVASAPAFVTGIMDDIEEISQLGLRFGVPVHVDATIGGFLLPFMEQCDYPAPMFDFRISGVTSISVDMHKYAYCPVGSSAVLYRDADLLYHQCYSNLHWSGGMYTSPTLDGSRSGLLIALTWASLLYQGRLGFVERTQRILDSSRMLRRRLEEIPELEVLGDPLGPVLAVVSTNPKLPIHALGDEMNELGWSFTFLQNPNALRFSISQHQTRGDVIDELTDNLKKCCEKILTATDYPYPTKTNVIFGISAAFSDRGIPNQLPNLFIDALYSTPTSPHGEGIRKRTLSIEGRKLSQLQRPGGLEALQELYAHGEHALVTFNAPPETETQNQNDDEQQQQQQEQNGGSIDTKYIGGTNTAAASMPTPEEEKEEKEGEGDNKERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDL2</accession>
    <name>A0A914IDL2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDL2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g987.t2">
        <property type="protein sequence ID" value="Gr19_v10_g987.t2"/>
        <property type="gene ID" value="Gr19_v10_g987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="223"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g987.t2"/>
        </source>
    </evidence>
    <sequence length="516" mass="56992" checksum="C01DAF6F9821C56B" modified="2023-02-22" version="1">MQPDEALNDLRSLGPMIGNCFADLFAVPPSHISIFSKFIEYFLGSSALLCFSSKVGQMQNPLDMATYRVGAETYRRNCPLETVSTAAPAAGAAFGMAEDEAGTSICAVDGAMLRHSGDEQTPSPTLSGRSSSSEVQQADFAVSECESPGKKVRLSTATTSTMTAEIAREIGEVSSNAKSGENVPLFMGRKTVEVVSAADGLMYTEKVPDNPLVGSVQYNKAEQYFYDSLRVPTDLVGLLCGKDGNRRNKIAEQNRCTLRFPKKQKPGSQTEIELSSTENALHVQACREALEKALVDARQKAAPTHFISVPIFDAAFRAQFSEMVDRICADETLPEELRNKKMYMTPSKLHLTLSVFKLFTEEEIQRVRHFLDEQFRSKNIRDILEGTDGKLRIEFRSLQNLGNQPEQCRVLFAQPKAESLQCLANALDDALTQAGLVQKRRSDDVLLHMTVLNTKYLWKGWQTVDATQLLEKFGQLQFPPVDVEELHLCSMRGNANASDPNGYVSVHSVKFASTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDQ4</accession>
    <name>A0A914IDQ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDQ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g966.t1">
        <property type="protein sequence ID" value="Gr19_v10_g966.t1"/>
        <property type="gene ID" value="Gr19_v10_g966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g966.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9878" checksum="86F413B9D912C3A7" modified="2023-02-22" version="1">MGVLWRPNRALIRSGLHIDQQIGGLSRQRKPMRVEENRCERKRGKCSKGGQGRKIGAMNINECGDDWKLGIVKIDDKRTTTESQFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEV3</accession>
    <name>A0A914IEV3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9262.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9262.t1"/>
        <property type="gene ID" value="Gr19_v10_g9262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036696795" evidence="1">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9262.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29830" checksum="BBA175E38B8A3E79" modified="2023-02-22" version="1">MMSFLFILILVCLIEIISDANGQTPAERQNIIESSKNEAKAVIAYGNALEFLKIFFEVDQELNLDSSKFNRMSNDQQISFIFTYINIKLEENEREIGESLQQITNNLLNYCQHFGSTKYGSDKKTINHFLLVARRTCFIGMFVSLAEFINKKMSEIIEHAQIMSVRVRRVSAVPTQFLQRQNDSQIQEMNTNISDYAICVEHMFIFWTRMKSEFIAAEQPPHIGDNGNANDVENGSWHKIKQQLNELTRKSLHGFDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFF0</accession>
    <name>A0A914IFF0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IFF0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9409.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9409.t1"/>
        <property type="gene ID" value="Gr19_v10_g9409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001774">
        <property type="entry name" value="Myoneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="206"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9409.t1"/>
        </source>
    </evidence>
    <sequence length="546" mass="61888" checksum="6F0EBAD4F50D359A" modified="2023-02-22" version="1">MSDLTEKNVQQTIKSAFENKHNDEIKGIINASIDDKMENHFSKLAQLFQNAAIIVGIAIVLILTTGKLWGKVKIALNERNTPQPAEAKTVEEPAIPLEAEAWWQFHSIPLPKCADFVALHPINLEGETNNNVNDNGGQQILMVDELHEECGVREEEEEELMEKNLFASRMVERPLKCNIFGHRSAQSFDLQLHMCTHTGVRPFKETNNNVNDNGGQQILMVDELPKERGVREEEEEELMDKKEKTKHEEEEEESTDEEKKESTDEEEKELIEKNLRATHADEGKKFKCTECAYQTAQAGNLKRHMRAHTGERPFKCTICGHSSAQSGDLKLHMLTHSGVKPFRAVFDFRFRLFFYFRHSPEALQMYNLWLSINTRRKLKRHRRTHTGEKPFECTICGHQTAQAGNLKQHMRIAHPHGCKRGEEGGPSDYTEIVECYEGAHFCVAASCIYLNSGFGPQPKVKKATNNVTKWACAEHNDPRYGMSADIPDIDMVCDEPRFIGEKDVDLANINYTGVFPTAAEYKLTGRNPPTKTPRPMANAGKGGTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFX6</accession>
    <name>A0A914IFX6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFX6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9542.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9542.t2"/>
        <property type="gene ID" value="Gr19_v10_g9542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9542.t2"/>
        </source>
    </evidence>
    <sequence length="336" mass="35836" checksum="EDF4E6060F49D548" modified="2023-02-22" version="1">MAAEEVVVNMCMEVDSCTSAEVELDKAVGTVEESIVVAVRTEADSIAPAVADMAEDSSSNRRLHRRTGMLMYLMYRNVYPCWPFIIGAIALNLVAIFGMVTNLGVIWTTYCTKTLHGTANVLLALCSFFELLHQQGHLLFLYVALSGQNFISLSMAIRWCTVSLFALGGITLSMTFTGLDRLLCVLFPTFPNKVKPLPYLGVIITLCVIFSLQNVMNFYELASTMPFLMVPGTIGDLMKQFPLTDRSSMAGEGVAEPGTEEGMEEDSKSTEKGTAGGTAGGTGTAGDTAGGTGTAGGMAGDTAGDTAGGTGADSNSSSCCLRHRRKGMHWRKAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IG04</accession>
    <name>A0A914IG04_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IG04"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g99.t1">
        <property type="protein sequence ID" value="Gr19_v10_g99.t1"/>
        <property type="gene ID" value="Gr19_v10_g99"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038102102" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g99.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9013" checksum="0D399053961BC5E0" modified="2023-02-22" version="1">MNKLFLLALLCIGTIQCVVNAAPQLGMASGSSKNKMASNYQHETGVLQIGRILHDVKRLRHLASSRATMNAHARINDLKENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IG31</accession>
    <name>A0A914IG31_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nephrin</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g9582.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9582.t2"/>
        <property type="gene ID" value="Gr19_v10_g9582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1093"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="53"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="173"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="282"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="381"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="486"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="581"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="785"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="875"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9582.t2"/>
        </source>
    </evidence>
    <sequence length="1340" mass="147777" checksum="C0E643F05E6B6F2E" modified="2023-02-22" version="1">MIVPFFPYVDQRICQSYGVGHMAHPSKPKQMLILHIFCELLKIFGIFYVLLLPLYLPIADAEKFHFKEHPANQSVLIGSDLSLRCSIVHHHGGSNPFHLQWRTNRGIILNQQQSNEIPGYSGRYSYSKENPEELHLNIRNVSLDDDGQFQCQLLKPGGKFFRANAFVTVLVPPSGVRFQHYQSGSTIVVNEGIPLNITCLTETSKPQVNLNLFVNGKKAAENVFRGRQEWENGTIDTYASLALRPGKIHHNKVISCEAQHPETNTNLRDSITLDVYYSSDRPKIDVIGTTPAGMAALKSGQNITLLCTAEGGNPPPQLIWSNQNGRVNEEYSYDMGSQITRNAYAFVVQGPDNGAIYECASQTNQNMSPLISRVTLRVDYPPASVFIFGNTVMRKGESLTMSCVSGVSSPASVVTWQLNGSPTKIQPQEQKKQLQGFVTESNLTIDSSTLLHGQNQITVECLASNGEGNAVGKSHIVRVLSPPSHPFIFDAEPNTVPLEGTLYNLTCEAKDGHPFATLSWFRGVEKLKETQNSLNGDSSRSTVTLLLDRSMNHQQIRCEAENGATDVPLVAKKNLVVLFPPSEVKIQPSRAVHMVASSPAELTCSVPSSNPVAELSWEFPNTVNRQLTISRTGEQIRRSNKPISEYHGFESTNIIQFTPSEAMDKTEVRCTASHHLWEGVKYGSYVLDVKYPPRIAVDGPVSIVIGEGQSFEENVTIYSNPRVNAYAWRKNGITIDRTVGSIFVRQSLIGGNGVTKEASGIYTLFVSNGVGTANATIKIVVEYAARITYITTPVIASVGEDVVLECEADGMPMKSGMIKWFRGNNEVRSLVQDQRRSVIRMNASHDNSGAYTCTVDNGIGQPNYTTAYLLVRRAPVIVMNAAFGRAAGPIGGKAILRCRATAVPNAEFTWGIEGEGNMIVHYNTTKYRFFDTQLDHTTFQSTLTILNLEELDYARRYRCRVSNRLGLVQTFIAVGPPTPPEMPTELEIVNVTNSTASISWTAGFDGGSEQMFELLYQDMDNNEIRSLNTSETQVFLKELKIEHGYRLQIRSINARGEISDLTQPLLFRTMDENLQSGGGFNIISKDGPFSHSAIVALCVALFGLLVLNCLLICYLNRRNKRRKMREKSALNQNGQCGSGRGIQIYGALTALNQQGSTPTTNRSELGAPVASGTMVNNGGCGRNSGGSRGEVLSVVDDNQSTRTIIEVSPYGQFNAPLYNDNDYFYNSTCVAEFDGTESTTDFYAKIQKSCGNGGNFSGQQTPFDANLSYQAIPNPQPPHNMSSTASIQHFGMMTNQICMDMNHYPSPASPYETRSACFVQSTPSHGSTAREWRDQHSRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSC5</accession>
    <name>A0A914GSC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytohesin-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10759.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10759.t1"/>
        <property type="gene ID" value="Gr19_v10_g10759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF402">
        <property type="entry name" value="MIP16918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037126476" evidence="3">
        <location>
            <begin position="30"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="SEC7" evidence="5">
        <location>
            <begin position="38"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="256"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10759.t1"/>
        </source>
    </evidence>
    <sequence length="438" mass="50077" checksum="0FB2AED15BDDAFA9" modified="2023-02-22" version="1">MNMFHISLIGSTITVVCLLGPMASSFSLADLTPDEYEQLSQIRARKMQLLDEIQHLQDELAKTNERIESITRVPDRSKSQAVAKKKFNENYRKGLKHLVETGDGIKKSAIGDFLGEKDELNLEVLQHFVCLQALRSLPLVQAMRDFLLRFRLPGEAQKIDRIMECFARHYCSQNSEVFDHPDTCYTLCYAIIMLNTSLHNPSVKERMTLDNFSLITDSMNVSRALITDIYNSIRSEAFKFPDDDLRDHCSAALFQQAEKQGWLQKQGNRYKTWNRRWFVLANRCLYYFEFPSSREPKGIIPLESIRVRVLGQEIETGRRSHAFELYSPNTDLIKACKQNGEGRLLEGQHSTYRISAPSREEMHAWISAIQRSINKDQNIENVLEKRRRRIASGGLLVAKSSMATHQRGLVDDGDPPVASNCGDDDVNNNNGDCAVQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSD7</accession>
    <name>A0A914GSD7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10320.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10320.t2"/>
        <property type="gene ID" value="Gr19_v10_g10320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10320.t2"/>
        </source>
    </evidence>
    <sequence length="394" mass="43337" checksum="DC52F6747A2B6D6A" modified="2023-02-22" version="1">MDNPSGTDLLIGYLSLSVSCLAFGFAFVPLKRYDTRDGLFVQWVQCSVVFMAGLIINIARGLPPFNLTAAVGGFLYATGNVASVPIVAEMGIGLGMLTWGTVQIIVGWSVARFGLFGTKAQHVQSPFFNSLGVLITLISGLMFVFVYSRQNVADEVENGGGRATQSNIVPLNSTSSGERTVPSIRNPPYGSVNITTDEGQRRPQKLLFVTLAVCLGVLHGLMLTPIVYVQDTDQRASKNALDFVFSHFCAVFFFSTFYFVLYSLFRRGRPYVNPSLVLPSVAYGLLCFPVTVRLPAIIGAIVDVFLFKDIRRRRRLAWLFAAIIPSVEPDLEVDAADIPKDKRFWLPLATCLVHSHPMLLPLDADSYTDQEAFELLTKNIKPTDENGTEGEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSQ5</accession>
    <name>A0A914GSQ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10038.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10038.t1"/>
        <property type="gene ID" value="Gr19_v10_g10038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037686682" evidence="2">
        <location>
            <begin position="28"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10038.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27642" checksum="3FD33F87EF371033" modified="2023-02-22" version="1">MIHSLTGIMKELVLLFAISILPFFCAGLECKQGTAHRDIYNITDEDIYKNSICAAEDAKYCVAATCTKAGADAFSFIMWMCAPVINKKDCGRIAEEEAVSKGLTVTKNFVCKCPYGAEGEDFSNAKFELLPMPISTLLTCKKGDFDSEEYGGAYKAECSHDEDKYCYMASCAKGNKHVMTVWNCSPDTDCTAISAEVGKTVNAKKPTTTTGKPTTTTDKPTTTTDKTTTTTDNPTTTTDKPTTTSGKQTTTTAEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT14</accession>
    <name>A0A914GT14_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT14"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11112.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11112.t1"/>
        <property type="gene ID" value="Gr19_v10_g11112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11112.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="19687" checksum="ACAA2451C1748790" modified="2023-02-22" version="1">MTVSVVLIPLQLMLIVVGAVFVIITQCCGCKKKQNQADEAQPDADQQQSTASTPLSAAEVQTAAYQTLAQGQPPFTAALGTISQRPSSAAEPSPTSAACATNYALSGQNAISMKASPQMTSKMSSRECSMGATNYALDSPTGPARTSSREPAPFKGGGTHGAVSQRSSHGAMNVTNRSSHGAMNVTNYAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT55</accession>
    <name>A0A914GT55_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT55"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10159.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10159.t1"/>
        <property type="gene ID" value="Gr19_v10_g10159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037112382" evidence="2">
        <location>
            <begin position="25"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10159.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="32621" checksum="D8122856FEA8B339" modified="2023-02-22" version="1">MPQTFKKCLYYSLFFLQHILTIDTVPIADSTDNVPVSDAIDTVPVADAIDTVPISGAIDTVPIADAIDTVPIVAIDTVSANADDNVAAKAKIHKKKSGTHSVPINRAVVNNKPTNSLAAAGAAPSTTSKLLEKHFAMGLRMASRGLVESGKLVQRAAPYAKAASLNAGRALLAGTKHGFRLTTNYVVKPAYRWGRRLVDKCARQLLRGLDQNWKTSCERAAPAAKSSVPAQNRPKSQASTSSSASHSDEKSMQRRGKGIFIDEKRAQQKLTQQKLLQHSGSNTSGKLKAIVEYDETDDDDSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUV5</accession>
    <name>A0A914GUV5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUV5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11401.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11401.t1"/>
        <property type="gene ID" value="Gr19_v10_g11401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11401.t1"/>
        </source>
    </evidence>
    <sequence length="446" mass="50110" checksum="8A6F7B8D0A289827" modified="2023-02-22" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGIEPTGAYNGDSDLQLERINVYYNEANGGKYVPRAVLVDLEPGTMDSVRAGPFGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDNVLDVVRKEAENCDCLQGFQMTHSLGGGTGSGMGTLLISKIREEYPDRIMATYSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLTTPTYGDLNHLVSITMSGVTTCLRFPGQLNADLRKLATNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGVKMAATFIGNSTAIQELFKRISEQFTSMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDASADDEGEYDEHEHEQELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUZ5</accession>
    <name>A0A914GUZ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MD-2-related lipid-recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUZ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1064.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1064.t1"/>
        <property type="gene ID" value="Gr19_v10_g1064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF68">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037735889" evidence="4">
        <location>
            <begin position="24"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="32"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1064.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20250" checksum="5A8D11E507C50A1D" modified="2023-02-22" version="1">MGIIFRPLFVLLAITFLCIYCEDGRIFHQIRYKNCKSQFEVVHVGVLDCVRKDRCDFVRGKEYQIQIGFKPDRRVEQLKTAVWSHLGDAHGALTKFHMENENACIGSNITCPLEPGRTYWYRQSVSILREFPEVDVQVNWLLTSPEVAPRKDQKFPLQREVCVKFLGKVIGEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWG3</accession>
    <name>A0A914GWG3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BolA-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11388.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11388.t2"/>
        <property type="gene ID" value="Gr19_v10_g11388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050961">
        <property type="entry name" value="BolA/IbaG_stress_morph_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229">
        <property type="entry name" value="BOLA TRANSCRIPTION REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229:SF2">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11388.t2"/>
        </source>
    </evidence>
    <sequence length="114" mass="12749" checksum="1E09826B8F78E323" modified="2023-02-22" version="1">MLKIGVIIAGQIRMLMSSNSPSVEGPVTIALRQKLAAFFKPEHLEVECESRLHNVPKGTEKHFRRQRMVNKLLADELREKIHALRIEAKMPPEWKGEKQVLAPPCGGGGKSLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX86</accession>
    <name>A0A914GX86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GX86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12196.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12196.t1"/>
        <property type="gene ID" value="Gr19_v10_g12196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12196.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="22541" checksum="B5DB39BB5437275A" modified="2023-02-22" version="1">MDALRRAEPNCSRLVADLTRVYPGLFLFKSDGTKRQRDELMETDRQLTIRVASGGAGSARTEDEKKVALAEECDPAERTSGCGEGKVCAELKEAEKNGTDGRGAGRCVTNRFASSVDQLFHCDSSTCDSSTAECVPFSSSSVAPRGQPAACRCRPGLVPLSTTDDRSFPFRCGRANKGISTALCMLPLAFALRKDDMLEEDGGTTDAKNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXK7</accession>
    <name>A0A914GXK7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXK7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12289.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12289.t2"/>
        <property type="gene ID" value="Gr19_v10_g12289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12289.t2"/>
        </source>
    </evidence>
    <sequence length="522" mass="59190" checksum="FEE0D9A2DA5D17F5" modified="2023-02-22" version="1">MGCAPSKFAWNNEIEVKRRSPCCNFLFKCATASSSSPPAGAAELNEDIDLNLHKVLRLQPSISIEIGSGVNQPTEDRQQSVIFLIGGPGCLKGVLTQELAQEFDFVTIGIEELIFNYLPHKVADTVKNTVEMQTLLKRDPAVINLKWLLQMISARLATSCSQRFIVDIVPELSFIFKSNAFKMGDHSQRLDEFDRKHNVLFALELFISQEHQLLEGGSSSGLTRSSSSSSASSSSTKAKEKEDADNFTRGVDEADKGRLEKRLEAYHDCAEPFLKYFRKQKRVVKLDLKIPYNADLPRTVRQLFVDVGFSRNNDSIRVVLFLQSEYQADEIDTAYYNLRKIRLLDICHDREESLASQIRAIRKYIYRTAQLDEHILVLLKGLNNMEYPRSKQRINFVEYKTTYLDFYIRSVSRQSPRQRCRMPFRAITSTKGEVCLFPEAMSSRLCKKIGLIFGEKLSMSETSETNREANESRASQLSVSPCSPHQHPKMLFPPGTELNVPLSPSSRQSQRRACTTTAPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY36</accession>
    <name>A0A914GY36_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GY36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12271.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12271.t1"/>
        <property type="gene ID" value="Gr19_v10_g12271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF34">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE FICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Fido" evidence="13">
        <location>
            <begin position="308"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12271.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="55459" checksum="5BD6B6B60D6EA4C4" modified="2023-02-22" version="1">MALCQKFGRLLIGVEARFSARTGVTNISTRLNQSSAPTQIPSRLPSYKKLNAFSLFTKDQLAGQSGDPKLLKIVSTNWKNLSEKEKQNYYERAKKIGDELRDKFEKLTNEEKKDLWDKHVEKRDKRRRLQMKRKLQKFYAETNRPKRPLASHLVFVKECFEKQTEPIKTRDERNKIFVETSEQWQQMTDAEKQPYVVQGQCNIAKFRVEMAEWKRKYANEIRAWKEAKAKATQKARDAQFTEALFDWNIDGDRDVDEKEAIHQMLLEDSTHLVEKRERSSDDRDVDEEAIQRMFLAISTYLGRKETSQNQRNICDLHRSIAGNTFWAGKFRECIVWVGDFIIPTGPAEVPGKMRDLVAWINEQEKLNRQGQGMSIVWLATHAMHKLLLLHPFMDCNGRVSRLVMNLLLHRAGFGPFGATDSAPTFLLPLIVKEGGIDVERLLSFVERETETSSNWRERANERGETDRYTAQYFDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYB7</accession>
    <name>A0A914GYB7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYB7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11908.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11908.t2"/>
        <property type="gene ID" value="Gr19_v10_g11908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11908.t2"/>
        </source>
    </evidence>
    <sequence length="376" mass="42191" checksum="68CF5761802EC9F0" modified="2023-02-22" version="1">MPVIFWVNVLPTTHSINARNRDHANQMVQIFPLSVFNVKNSEDSIALFFNPITGVQVEQLRIPGGLSQLELWPFPIPSNSTFKLCVAEVYLFVSVGKEKDALISHWNDKVVVQYRFALCPTRYQIQMRSYLVIVMDTQFYKGKHHTYEDYPIGNVLHMVGLANKKDKEDDVDCQCVLMCQSSMKDFFKKFLFEPLPIESHLDHCLSSSRTLRHLDSAQFYSVGSATFAILHNDDGTTTGVNRRPFPTELFNNSYCSPTTCPKPNWSRPSTTGGVIIVQLCGNGHLTELLHKLRSINPTFAGIYLTQIRNQTSCRCPAANRFPSKTLTQSPPQQQHTHQQPSQQQLDAGHSADGEVTATSSPLSPPPSIACSNSSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0H0</accession>
    <name>A0A914H0H0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0H0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12913.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12913.t1"/>
        <property type="gene ID" value="Gr19_v10_g12913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12913.t1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43644" checksum="7B4639137036474B" modified="2023-02-22" version="1">MQPVGCLKQQQQQQQLIGRKKRSRNISFPGRKFQQLGFMIESLMMDGSSPRGRASERTLSMQRRRLLHPSIILSLSLLLVNAVSSEAASDEQQERGHHHQHNDHDCTGHSHQHASGEDSSDPGMPDGGPKTTNIRRHPVHLYKGAEPWRPLSNSIPLLGVRPVELSAATIDEEEQQPPAENEPRHLAMDGPPNNVPLKVSGTINGFAPINISAEPLAESTAFDYNENAREGDKERSKSALHESLRRPLKRLTDRQLALLLKQIRKQRRGQFGQSHRETDQTAVPEMNAISTRQEMLAQIKDLLKQPQNGQHLIRPKLLTNVNILPNEWNIYPKSGEKSDERQQQQQQNGLLDGRPGVQQKQPLSVYTIEIGGHLYDLSEEQPPNGTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H292</accession>
    <name>A0A914H292_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H292"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13331.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13331.t1"/>
        <property type="gene ID" value="Gr19_v10_g13331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040128">
        <property type="entry name" value="T25E4.2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22714">
        <property type="entry name" value="PROTEIN CBG02446-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22714:SF7">
        <property type="entry name" value="SOLUTE-BINDING PROTEIN FAMILY 3_N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13331.t1"/>
        </source>
    </evidence>
    <sequence length="1108" mass="125514" checksum="BBD48945243AB99E" modified="2023-02-22" version="1">MGSAQKRAVKGVIRIIFAKNPPDAFTTCNSFPVLIPSMDCPFPGWLVEVVKMLADYLSFQIDPIIIQSEIGNVNWGHNDSGNWTGILGILQQGMADTVCTLYPFTEQKARFFNFSHPVTSVRDLYIAKPKRKSISLVLWNAFLPYEPKLWMLLFLSLVIQCGLASLVCNIEYRLNLRSTYSPLEKLWHYLRLQIHQATEIHTPFHLQSGNLAFLFYALIQATLFTQLYTAVLLSALIRGQNPNPWDSYKEMVHLVRDGTYSLVMDKHHLHKDNSFYETLSYYTNLSQLRNLADAIKNNPIIVVENVSQSLDYVEKGGFILPTKQFSLAYQMSKERCDFFYFEDDNNQIPTFFLFSRHSKLLREWNRAIQNNQAFIRRTYEKYFFNSFNTGNVPRCKRTTADDKLEWYGGRSNAARDASLSLDIVSTFGIFLIVLIGFTIALLAFVCELLVDAKARRFHRKWHIRHALVFTASNPTHLMAIARQMHHKRKRMTHLDSQTSTETPPAFFREGNYWWQRKTRQQNSNGRSNAIIAALTLAAISSVKNDEKEGEEAGRAGEGMRKRKQNNVGGREWMLGRKDGRGDEDGWMRTPQFPPIAPKQNSVLINSQQNRPPIMFCSRLAPMLFPIAFLCLSSPGGCAHLSAAFGNESEKNGTRSAMAHNKLNFGSGLYGGEGTGEAAGEKLWKLSNDFEFEEKQKAKEMAAEAVKETTKSARQQAESTERMPNGEKTAEELKKKTNERVEMKQNETGIGEDKFKKLSINGTMGTTSPSSFLAVETVTYGVETAATNSTSLSGGGGARELDPMVDDVFALLNTGSDDNTTTSNGVEVEEGEEGEEAEQILQCADQLSTFVPLLLMPPHYHDWNFSCHFLGNQSGMNSDQSKKNPNQNDDIFWKMSKPCRSSRSFRHSIASQPDCHLLIGFVDHLHKFPTNTLITKLRGTTMDGQGAVVRLVCANEMEQFIGREADDNERKKTNGDEETFLKTVVVAEKTWLPGCIAVFFDSRTLDLQLDNMAKLLWKGGEPKFGTTDGNNKWAASKFFCGEKERDLFYRELYKMKARNEKVFNGILIIGAGESEKRNVLLKKLDEELYCAEKTEERGFFQRLWNGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H396</accession>
    <name>A0A914H396_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H396"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12859.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12859.t1"/>
        <property type="gene ID" value="Gr19_v10_g12859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037908234" evidence="1">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12859.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25977" checksum="EE14ABBC514D2802" modified="2023-02-22" version="1">MRASSFLLLSIVVVAALAKDDKAGDGRGKERRDRPAIIRSRRSTFGTIGSGIKLAKEATDKGCKVLRTKACTTPARKQRDTPAALLENILPSDVGALVEKSTTELKKATETEGFHELSEAAQQRVLLEAAGKQGEIVKEKLKKAIDEAGKTVDKALDKIVSYSEVPVEAKMAMKQIFDTLTDETKTPKQKVERVKDLEEKLSPELKESLKPNTDEKAIDEAARFFSSVPQQIELGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3Q9</accession>
    <name>A0A914H3Q9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3Q9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1298.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1298.t1"/>
        <property type="gene ID" value="Gr19_v10_g1298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037563019" evidence="2">
        <location>
            <begin position="24"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1298.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35615" checksum="9287B1C83F46EE1E" modified="2023-02-22" version="1">MKNILLIYLFYFSCLNLCSFISAASLANKFEGQISPPGASPKVQRCQCGKHLRNLTATRIIAGKKYDTFVPLGDGLDGKVEHAFSLPLGRCVAVKTCVEDPTRLSKCTREMKVLQRMSGVAPHIVPLEDFQIKRGQPCTEGAVMSDFIRTVIIGSEKRRKRNVVDAENTNTNSSGSESIGDNCNEITLVEELGSDDVEHYLRGLKRSGGAGGGRGALSLELTKTLIKKALDELHENGIAHRDLHKDNAMIFPLPPLVNHSQRCDNAETGGENAKLTVKVIDMGWACCFDAQKCGPSVSAAVPDCAAVKSLHDDEFSLQDVLQELDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H517</accession>
    <name>A0A914H517_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H517"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14231.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14231.t1"/>
        <property type="gene ID" value="Gr19_v10_g14231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032924">
        <property type="term" value="P:activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF25">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="9">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="10">
        <location>
            <begin position="423"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14231.t1"/>
        </source>
    </evidence>
    <sequence length="630" mass="70102" checksum="83317E840C62D290" modified="2023-02-22" version="1">MRGIFEGGTSGSVKNLMQLMLCHGENPDIADSPASENGGGPESTKDAERTSLERELKIFLKKMRKRRCLNELRKAISAEGQYIKCVLYKVPKDERTAFGGQMKSFPHFICCKICRFPNLLTHHQLRPVVHCMNPFNKTQQMINICVNPYHYQRIENPRNPKVFVQRNAATESVEELSALAAAASAADELDDSAIIPNLTLTNDEIAASNDTEISNVENGGGPSSSSSSANDSGFGATMTTPTTTARTGTATTTTLVMDDNDEQMMDTGDHFCAQQQQQRQSICYNQRNGGPLSATSTASSYPNTVSPRGYLSDDLDQQMSPFSDAGQTSPLFVQQQQFMFNSNRQSTSNNNVNSMVVDSHMRLMAEETAHFDAIMMNTAEKHRREQQQQQQQQQNLNISNTLSTPSMHNNGISIVEYEEPLSWCSMTYYELNQRVGEVFHASKPSLIIDGYTSPTDEDRFCLGQLSNISRHPSVIDARKSIGKGARIYFIGGDIYFETLSETAAVFIQAPNVAARNGWHAATVCKVPQYCNLKIFSMSEFGKLLNTAVKQGFESVYSLTRLCTIRMSFVKGWGTEYRRQNVTSTPCWLEIHLTGPLSWLDRVLSQMGAPPDANKSYKIDEPLESFLLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H522</accession>
    <name>A0A914H522_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H522"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14233.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14233.t1"/>
        <property type="gene ID" value="Gr19_v10_g14233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037401812" evidence="3">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14233.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19389" checksum="C00BE8F81C55307A" modified="2023-02-22" version="1">MNTSCIVLLPLLFLTLLQLVVVSSSSSLSEGFSSSSTNSSKAPTHPPLKKALRMFRVKPEDLLELSKDMPLLNPNYKAHKLVVGHGEKMEQLQHRVSRLEQQLVETKQSQFAPMSSIEQFYIKHMFIIVGVLVCIWVLMLANLFWLHIRFASNANAKKHVRLESIDSEETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5X9</accession>
    <name>A0A914H5X9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5X9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14128.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14128.t1"/>
        <property type="gene ID" value="Gr19_v10_g14128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037457189" evidence="2">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14128.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="20870" checksum="F8519EA350C4C2A6" modified="2023-02-22" version="1">MCVSIWLKFCMVIKSAALNRGGTQSVALHRRHSIGGTQSTALNRRHSIVDTQSAALNRGGTQSAANSIGGTQSAALNRRHSIDGTQSGWHSVGGTQSSTLNRRHSIGVALNRRHSIVDTQSAALNRGGTQSAANSIGGTQSAALNRRYSIDGIQSAVLNRRHSIGATLNRGTQSGWHSIGGTQSAAHSIGGTQSAAQLSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H664</accession>
    <name>A0A914H664_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H664"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14365.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14365.t1"/>
        <property type="gene ID" value="Gr19_v10_g14365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14365.t1"/>
        </source>
    </evidence>
    <sequence length="613" mass="67883" checksum="8EDA329F92712508" modified="2023-02-22" version="1">MEDVLVSTVDGCQGHEADLVFVVTTKMGLLSMDASGAFWNDERRVNVALSRGKFGMVIVGDLKMLWSAGGIWRRFLRKALESTIAVAPEYSVAMAHHSSEYIDGMLYGPNGPVKADNFYDEWGYSGFDPIPGQASLRNHSPADGRPLKVDAKRKPSPGGAVPSLQTPGPLYQRVPGEESARGQSGPQPQGQMKRRTERVIKPPAGGIWRRFLRKALESTIAVAPEYSVAMAHPSSEYIDGMLYGPNGPVKADNFYDEWGYSGFDPIPGQASTSQRSETTPPPMGGRRKWTPSANRRPVGLCHLCKRRTERDRAEETVQYPKLAETTKTGHQRRPGRRSTSSRKKLSWLDDGILKTGETTITRAHHDGHVLLNVQEGKSPRQAHLLQWRSPATIGQPTTSSSSASNERPGREQQTREKGREGVVDLSERRDGRATEATVEESRTTESQAEELTKAKWEGWRPTKRVIKKSHSAKKKRKKKSKRWDEKSQIGQPLLRCAHINDGRTTEGTEEEDETTGESTDSDRYCQSFLSYGCTGLSNKAVSGLIGVGESRGTPGPGSLDQLHHLSTPISSSQALSLGWTPTALLHVRFPVCSPPFFSALHWKKKFKNVFRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6V3</accession>
    <name>A0A914H6V3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H6V3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14367.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14367.t1"/>
        <property type="gene ID" value="Gr19_v10_g14367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="261"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14367.t1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52733" checksum="8A647B1AB5B0BDA4" modified="2023-02-22" version="1">MPKPNSSLGRMKHLLETGNGADVHFLLLLAHSQILMAASDVFEAMFPFDAQNADPSEGIKPVEVTDVEVGAFKAMLSFIYADDLSGLNGDNAISVLYAAKKYDLPELVNSCLNFPIPELSNIFFAFAQTRFLGEEDFTRRCLAYIDQNADALLLLEEFLQIDQQLLCEILARDELYINDEIAIWNAALRWADEKCRQNGKEPSAENRREMLGPALFKIRFPLIPQKDFTENIVPSGVLTRDEIISVYLYHSHPNPGLPELYQLQFPTNERTTTKSGLTLQNRWDSAACHEDLTLIEPKRLIVQYNGNNYAWRSVRAEWVIPKKDFGVFYYEVTILEQANNVCIGLATKQMPLDVWVGRYNGTYAYESCGRFWGHAVEGCPYGINRRPYIGGEPSFGMGDVIGCGVNLASRQIIYTKNANHERLLYISTQDISTLDISTLISTQDISTLDISTLDISTLDVSHWTFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7S9</accession>
    <name>A0A914H7S9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lethal giant larvae homologue 2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g15.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15.t1"/>
        <property type="gene ID" value="Gr19_v10_g15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="7">
        <location>
            <begin position="394"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="667"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1075"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1135"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1293"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1541"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1301"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1550"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15.t1"/>
        </source>
    </evidence>
    <sequence length="1617" mass="176240" checksum="B80152D5558E755E" modified="2023-02-22" version="1">MPPHLILGSATTGSAHSTHTNILRVENWLRKKPFGGKHIDEVWLFDTHIPRLFLETSCASNQFVEQKSTSRTQRHMDRARRRLASAIDGIKAQFTDADSEDTADMPSTATAPPAGQQPMVRERVEPSHCRLSKIVRHGFPDAPKCMAFDPVQKLCAIGSGQGCIRLLGQAGVDQLLKHEPDEPVIHLQFLINEGGLVSALQDDTLHLWNFRQRIPEIVHSLRMSKERISTVYLPFQSRWLHVGTEKGNVYFVCLATFELSAYAIQWNKAIDLSCRTHPGAIKSLEVSPVDPTKLLIVFERGQLVLWNILTREVDRFCSDEQSSPVTAISWHFDGKQFMSGHQNGSLSIWNVKKPRELVQQSTPHAPSNDQQQQQEGQEAEEEDVQQHQQQLNTVTCKPITQLSWNVNADAEQLIIFAGGMPMDEGALPSVTVMRAKCSLTVLEMDHQIVSMLPLQASPYASAALHPIAMAVLLRNDLLVVDMQGQGYPCFEVPHPMDLHESPVTIIRYFSDCPVELIAALTLVGRNQRRQGVRLSERPWPINGGIGRECATGQQEMLLTGHEDGSIKFWQASSEQLQVMYKLKTGRHFEKTIAHIASTAVAHSGEEKPVTPPHVSHAVADLELCSDSRQLLVASRSGQVTLFRFAKTECCQEIATVMLPQLCRTTVPTTFSPSTPPSPKDGASAGGDHSPRPRAGSQSRLKQQSRNSGSSGSVTGGGGGGRAELRRQPRTVVDASSTPAAPPGAAVASSSSRNSSHSTDTSLGSHYAEMTPLKVRGGVLRRPAGYQPELVCQIPWINGSRPERVTALALNSAHGLVALGTKVGLALVDAHTAAQIYAWSNEELLGREPIPFWSASLNSQVSEMAISPAVEQLQLTMASSSSLSTTNTPRKRHPLARALSIRSPCIKSSPSTPLNSPPIRRGSLLKKMVAIQTKLEAKFGSPKHADDDEQQRLVQAVHATGPQHASDQFWHHKKMAKKLHCRPSTPHGSETAADNVGTSLPITLVQRWQSFGTGRSTKKARLSRKHSAPEIVVVGSAAAPFERMQSDRSEDHLDSVDRHLLRSLGLLLSHPAQRQFSAQNAPKSPPPVPPAPQLSRHNTTDSATAAGQQSSTTEKFGASLNARLQRPQLVKAFTFNPTQSSSANGDGSPKEFGASPPQSAGIEPHNCNGNLSADSRASSSESLDKQKKAVSTANVEEDDEFVCSLQFINCAAKRKVPKLELCLWLGTSTGAVVAFQLQMPTNRIVSTVSVTPSEMFNGPKGQIIRLRGRLLCCAFLDRSFCLLAGPTEQYKHQQMHAELSKDGSTTSAPQTAASGEQQQPLRPNKVITKASLSPVLSVTGTENPAAASEDAFQQLALFVSEFEVRAVQLPSYQQLFHRGSLDAEPMLKANCSHISGHPVLITLTSKGNLFVLSLPSLRTLLHVPLIGECVDMENLIFNRCDFSEHGLGIYAVTPTEVQKLTISAEIANQVNDCMGELFVPCDMPEAPKHHSFLRGILAAGASAVSGIRTGGPDPVAEMDALLREKPTTGVQSTMRTVARPLVTPQQQQQQLSGTELSTSRSVTAGQAAQQALQNLGERGERLNSTIDATDQLRNNAQAIQSRSAKLLEKYEKRKWYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8K1</accession>
    <name>A0A914H8K1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8K1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14238.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14238.t2"/>
        <property type="gene ID" value="Gr19_v10_g14238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14238.t2"/>
        </source>
    </evidence>
    <sequence length="552" mass="63295" checksum="A7FB980EBBF99227" modified="2023-02-22" version="1">MYKLCCSGNGEYQGGKVPKDLPLMIDLRFFYSVKMAVVFILMLLSSTTLKAQRNENDKFYDLMAAIGEHFGGELNKAEKALELDLNESELSIFDYWIEIIEMKTKNTQKPIFGVAIYSEKYDGFKSEGSKERAFKLSRENYKILKQLNDQKFSIYESLNLLKAAFNWAYSPTRRIDPELHFDSQDKEIQQEVQKDFEENCKKFENEEEKIMFLNNVHYELAINFEFNHRKGKEQQEHQHQHHQQAQLKQAKKVGDSRRRRRPGAWPTRAIGGMEQECEGSGVQRAKIQQGQVVQRGQAFVRTGQTGTGEAGQWGFSGVQLAEVHPGQNFLQHGQFRFGQAGIGGSGQTGGQGGGGFQLAGIQASQQTFRISYTNSKSGQVKAVNMESSWHLEFNCRMEFSTARTLDTIDNTDRGEAANGDSAVFSVPIFNMVKSLGTRSMSAKPGRWRMEVSMVKTFCTRLLSASPNRLEAVRWRMEISMAKTLTLDNPGRLKAGRWRMEYQWCLEFKWHMEFSMVKTSCTSPKSAKPGRLEAVSMKSRWRMEFRWPMIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8V2</accession>
    <name>A0A914H8V2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8V2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14830.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14830.t1"/>
        <property type="gene ID" value="Gr19_v10_g14830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858">
        <property type="entry name" value="OS05G0521000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14830.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18463" checksum="8484A6F7954A408D" modified="2023-02-22" version="1">MDTMQNLRECDQNDPKAFIQITDSLSRVMKQFEYEKSELCFNYDIRSRTIEPVEVGVNASTGQNEISNSEPVEVGVNASTGQNEVSTSSVQSGDVHGISPTNNHLPSTDSEEKFNLSPCAICFDKPREITFIPCGHLACCRQCADIIKNFCPMCRGKIEGKQLTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H912</accession>
    <name>A0A914H912_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H912"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14366.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14366.t1"/>
        <property type="gene ID" value="Gr19_v10_g14366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14366.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22006" checksum="D5DE3546822896A0" modified="2023-02-22" version="1">MILMDPVNRGLNTVRQSITVRVCSGHVADDVWFDIFALFGRVKLGLTLALISDRFDRLVDAHLAIRQSQHRCTAVKLPLPQSPPLKGIIGFNKITIGYIDRAVINFVRHLFNVDITLQLEIRPAEQRSWHILTHEIWPIVSNKLYKIAGSKDNFVLLRLRQHFGATVLRVCQSRFIEFPAFFEFPAVADDCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBN7</accession>
    <name>A0A914HBN7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RanBD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBN7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15622.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15622.t1"/>
        <property type="gene ID" value="Gr19_v10_g15622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13180">
        <property type="entry name" value="RanBD_RanBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="165"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15622.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="41812" checksum="9B0D08B2FF677C5F" modified="2023-02-22" version="1">MDLPPSKLSSAASRLWGESTGQFQKKTDVKIDLGLHQKIQSNGSEEKASTSAISDGFVFGSRVFERVTSGKSDNPSSESSDSRSRVDRKPMDVSSIFKQMAKSTETGADTANMWKSTFPTSISNGSGGIAVESALTMGGLGESAKELARKCSQSGELAADASEAELQKIKTGEEDELNLLHISCRFYQYNGETKVWQERGMGSLKINQHIDARDDVRLVGRQSGNQRVLINSKIFPEMILEELSEKRLKISAHISESELPQLFLIQASPGSIGNLYGMLQKYIDASNMAKATQQLHLRKRRLGDGGGGGETTENGVGDEDNSVEEEEGTKKFAHDEEDAKQKKKKEGEGEERKDDGGGSERHSKTKKRRSISGREEEGVEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC78</accession>
    <name>A0A914HC78_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HC78"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1576.t3">
        <property type="protein sequence ID" value="Gr19_v10_g1576.t3"/>
        <property type="gene ID" value="Gr19_v10_g1576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000019">
        <property type="entry name" value="Ligand-dependent corepressor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545:SF13">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 93F, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545">
        <property type="entry name" value="TRANSCRIPTION FACTOR MLR1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH psq-type" evidence="8">
        <location>
            <begin position="753"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="720"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1576.t3"/>
        </source>
    </evidence>
    <sequence length="871" mass="94083" checksum="845E552F321E89A9" modified="2023-02-22" version="1">MLLAQRPNYATDAANPPKRHYLHSFQYHRKNGSNTLPPPHPPISSRQNAASYPPRPSIFLRRFILFQRSVQNCHLTSADPPIFPATTFHNARSHPFNFSKKSSDVCNDRCSAERRVHCRELSKGSRQLLMLVGLENVFQRALGPRQWRKFGQAVKIASSRSYSADFELDLSKNCNWCLGSRQRVSSFGSQSLLTMNDALLDDSSSLGRQLSSTHLLPPLMTIPGHSSPPSASSSAASFSSSSIHSSSNASSSAHLPPDSPKRAPPPSETPLPSCSSSATNSVPDAMRLLAALHQQQQMLMGSAGAMNGAERMAMAAAIHLLGATMSSPASLNGGLSAGGSAMLSPPPAPAFLPAALLSSGFYPWPALLTPHPSFPFMALPNNSSSATSPSTPPNSVPNMFDIHQQLTMAWQSQLFALRLMSSFNEFCPPPTTADVQRDTMPSEDEALAFLAAFGKYSRTKSPTENGDQQPLDLTKSVGSLNQSSSLNAEKEKKASEKRGGDQMLREFCQQVNKEVESGGNASAPPLLLIGIDGVGGGEDSSEAESPKLGTKRTYSQADLDAADIRMGRLGTRRASVVYGIPRSTLRNKIYKLEAAEDNGDGSCKRRRLTAFALHKREQRLSVHRSLTESASGDSSFAEGEDRGGEGPGKRTADTPENAGEQSSEPVPLIAQMPSALLRQQSMPTFPLLGAGSAAGQFLKEFSSLIKQKVVSQSTKGAAEGEITETKGAKQQQQQLQQNFKTERREKNSTISSRPKRGQYRKYDKDALVRAVASVRSGEMSVHRAGSFYGVPHSTLEYKVKERNKLRMAKNKKSSGTNASPKNAGGEAQQSIANQKLSLLESEVQKTLEFVLNTVVHGAKTTEGETNTDRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCF7</accession>
    <name>A0A914HCF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the NDUFAF6 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15770.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15770.t1"/>
        <property type="gene ID" value="Gr19_v10_g15770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF7">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037656072" evidence="13">
        <location>
            <begin position="24"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15770.t1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47408" checksum="D992D4C4D30B58AD" modified="2023-02-22" version="1">MSSNSSLFWRILCSLSVLSLTHSAYSAAQHRSYLRLVGQPFTHLPVDLIAQTLLSLLAAIVSTSFVVGDFQPIRADLLVAKKSWDVLGNCPSFYVFNHRAKYACTVSARRFPSPVLLFIIYNIAALDYCVKIVQERDYENYMAILQMTKSAQPRLFSVLALNAEIASLRHKIKRGSGLAGINQLTFWKDALQMFGQNAQKTLLPRQPVMTALSAFGSREDVPLLLQLVSARQQTLGDRPFADVHALESNARALYGTMIRLQMHALHDATAATQDGEHRQQMLEYEDCQRAVDAMACAVGILTLLRATVLLLRDGVMLLPQDLTTLHGVSVEMAYRKPNSLKEVVRDLCEISTRHLHTARSPSCIDSVRPELRPALLTCGLRADHVLTLLNSNDFNLLDVRLHQRHPMSAWKLWWRNRCKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD07</accession>
    <name>A0A914HD07_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD07"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15985.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15985.t1"/>
        <property type="gene ID" value="Gr19_v10_g15985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15985.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11568" checksum="80A607B0E205B463" modified="2023-02-22" version="1">MSSSKWNFTSIASNFEADNQDEQGERHEREVQQGSGSQKRQHHPNDDFDPGNDSENNEIDNTDDDQFGFYCEKIFDFYCEIRSNISYSGLALLSNYLDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDL2</accession>
    <name>A0A914HDL2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HDL2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16044.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16044.t2"/>
        <property type="gene ID" value="Gr19_v10_g16044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000012">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="336"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16044.t2"/>
        </source>
    </evidence>
    <sequence length="561" mass="63907" checksum="92E8B18209325E29" modified="2023-02-22" version="1">MPLNETADAENDDINKNCKVKARKEALLKKKMELGDEFKSKYELKTPKGTRDFGPEQMAIREKVLGIVTETFKRHGAATIETPVFELREVLMGKYGEEGSKLVYDLADQGGELCSLRYDLTVPFARYLAANKIEKIKRYQIAKVYRRDQPVMTKGRYREFYQCDFDIAGQGELMMQEAECLKIVEEVLTKLDVGEFEIRINHRLLLDGMFAASGVAEHLFKTVSSSVDKLDKQPWAEVREELERDKHVEEGTVHRLGELVCLREKHSDWDNQTLLEWLTKKRWSEEGNFPSVSDKSLQNIRQGVDELKLLFQYTELFGCDQSRIVFQPSLARGLDYYTGVIFEVVLKEFSFNSNVASTNKRSPQKKKNLATEENSETESSGSAILGSVAAGGRYDKLVGMFTDMGRGEKDGGKEGSAKKRPDVPCVGVSFGIERLFTVMEMKAHADAEHTVRVSPTQVYVTSASASKDISAIMLQERMRLCGQLWNAGIRAETNYKTNAKLLQQIQFCENKNNQIQWLLILGAKELAENSVKLRCIPTREEELVKMEEIFQEMVNERNSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDN0</accession>
    <name>A0A914HDN0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDN0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16057.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16057.t1"/>
        <property type="gene ID" value="Gr19_v10_g16057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16057.t1"/>
        </source>
    </evidence>
    <sequence length="631" mass="70444" checksum="767EB10CE3E92F45" modified="2023-02-22" version="1">MTFQLSLKNLGQMEKRFEFNFALFITFCFTGAVVGLPPLPPPPPPKPAAAGAPPPPPPPPPPLLKSGSGKLALSFGDAIRQKAMARGGASGDVSGGEKAPPPPPPPAKPPVPSLPTASSSLGSPARRRAPTPFPSPRNSDESAPQPTPIRRRRPTPFVRKASESEEGVRRVFVSEESEKEALPASETASYRRRSSPLSLASSFSRSSVTTPTRSRILTPPTSESEEQTENIEMERSRGWREEQRLDYEKDDSAEFSSSAEFVNRKFAFDKMPESILLGFPLPPSPTGTFPAQFVARDFASGSDVMDYRRPGEADEGRVQEVAISGEFLCGRSQRFHPAAVYLREFFWESGVRDRSGTFKHPKFMKRIVGLYALRPTFGSFTFKIVRPAASYQVHNGDDSEPKMSRKNRRRWRRGGFRVGKKRRSGGKELAPKGEEGEWPVLEAEHSQFELVFDRGGCDSTHNESEALSEGGLCLSEFARKPDWQDRKWRKALDSERKCSTQILDRKRDRICVQKVGDVRSDADFVEKSLGPIRVDKCTVSERMSFEFCANFKCFDGAELFLPEMQPHEQFFMRIYTAFAQFLPFCDVSPTNDGHTVVIGEMSALFPGLRRLFAVFLQLLAEAVPRMPMQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDR9</accession>
    <name>A0A914HDR9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDR9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16081.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16081.t1"/>
        <property type="gene ID" value="Gr19_v10_g16081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037172753" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16081.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17009" checksum="4F8C98F8488F2041" modified="2023-02-22" version="1">MHFCVLILGIFVLLMAASVAECGCFWSMDSGERAQKICHKCKKKDACSKKKYESKNRFYKCEWDLIWKECNLFKESKLSNRNGEHEKLKQFVCDLSEHEIVIGEALNDQAHWQLFNPRTSLLVIVTPGLFIETQGHRLSGVRNEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEF2</accession>
    <name>A0A914HEF2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEF2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16757.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16757.t1"/>
        <property type="gene ID" value="Gr19_v10_g16757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16757.t1"/>
        </source>
    </evidence>
    <sequence length="723" mass="77940" checksum="B9D547CC512153A6" modified="2023-02-22" version="1">MSSSTSLPGAVDVERLRRVELLRAELDRSLKVAAAASSLSGAAEKRSPLCILFHSADSVHIQFSGSARASVDLFARPRVGTASRFIVSPTPNAVPPAAVPPLLPPKTESSTASAWPLRVLTTTRQKDAELLENVACATAAVDKDKNESSINSGAIILLPTPPLVAASSPASSVDSGVASPGAAGDFLLNTAPFRPSTTEQQRASHDNPVKGLFNGPSWATVPRTRRWIFNFSSNKNINDDNARSPLIDALALSSSLSSGGSTTEAETVKKPTTVTELSSSALQQPPVLTLQKPPLKKKYGQNTDNSHQSSPPSQSEVSSNGYSSNLGNNNFSSTLSPTESPMVAVKTESVVNNEEVDSVASRRHPAAQQPSSNSSSSVVLQRQFSDGCCYNNGDGTVLDADTEELHGLPPRAATLPPLRSILKKPRASAMMVLNSNGQQLQQQHFLDSTLPRNHLRRMPTRIVLERSVSESLLYDAVPDDQFSTLQHSAAAVFNASILRKLSMASTPVLGSFDEKLEEQHIKAEQEQQQQKQNNSGSISSSCCPSSCSSETIDSDGSGQSSAAPIAKKRVSFSEHVQARIYRSNSSILGQRRKNEKKSRNRCTRRCSSDVEHSSATEAEVPQQQQPQQHHHDVVSSSSNNNNNISCKFYERPPLWALQSRQDFNRWRQEKEEVALWSSASSVVAGSAVPTGVASQYVLHSIPFRSSFSSPMLMMLSFHVPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF32</accession>
    <name>A0A914HF32_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF32"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16780.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16780.t1"/>
        <property type="gene ID" value="Gr19_v10_g16780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16780.t1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48058" checksum="073D6285095CF547" modified="2023-02-22" version="1">MVLAIATLDMLTYWMLNVSSAFMLSAANNVLFFVLDLHMPVLHFLHNIVPALFLLARLALSRDRPLLPRLLYAIVQAPLRSLLWRPVMAQLLVSALAARVHAHNRAGALYLCRIFDFLGTLLIIRFAADFSNSNVAGSKDELRRRRFAICTLLCPLAFSASLSWLEFGNIEWDPWALFLAPLLALAQAVHVMLLKRAQLEFFAALGMTPNGNGCECEHGDGHRHHHQRRALPDETFEWFSLCYLVAVGTLLAPTALYSYANSVVPYDASWESIDYLLMGMSIVFMTGFKYSELWLISRLEPYQFCALEHTKYFMASIGQWFLQNMAHATIFAAVGKALFVVSALRYWVRADEMETAGTSGGIRAAKENRWRLSGRRQGEKSIKEYCPEALLGQRGRVIADQLRPRSVSRAGPKQYTNSSATTPLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF97</accession>
    <name>A0A914HF97_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF97"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16079.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16079.t1"/>
        <property type="gene ID" value="Gr19_v10_g16079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="4">
        <location>
            <begin position="60"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="287"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16079.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="57199" checksum="CFDC068D8679402A" modified="2023-02-22" version="1">MQKAHALFVINIFLINQLKPILFAEMKIFGFLAFCLVGTLFAGLKCFNVLGNEIFDVPYLDIQNITIDQLRKINVVSGDITKQKVSIIVTDANSQLRHDMDLLELVLNTFIISNGSDYTPGSVVVTDAFGNLRKNVQFIAHAVGPIVQGINPSAEDTLALKLCYTRSLNALIAKGGQTIAFPNISTGINGFPNELAAVAALEAILNWLNTNANEHQVQQIALVCLRQSDKKLYKDLIESAKRQIVSSRTSTPRTSVASKPSKSQASAPPSFAVNPTVIVEQANRQTVSCVDVQGDGDCFYRAICFGLFRVDSRKKADALHFYPRKRHRTHADFTHELSQLLLESPSDLWYNQTLKAYSKHIETSARHSSGRWAQLDDAHTIAILLQRPVVILRPIAGDKILRKKMPNWDDTSIKQRIDVRFPDGAYMGMTRNIPHVQLNNFTVQQRTPQGVLMERTVVNPIVIWFDGIEHYQSIIFDPISPNASAGSKNIFAKKFDIPEDYLYGTGAQRHGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFD7</accession>
    <name>A0A914HFD7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16109.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16109.t1"/>
        <property type="gene ID" value="Gr19_v10_g16109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16109.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10122" checksum="81190C57ABBA2FDD" modified="2023-02-22" version="1">MGKVSKSPAPISISPLRAPQNPHFKTLCACLVGGRDSRRDNVNGHSRRLACFARSLSSVQPPDVAARRWTTALSFMFFCEGDQIALIRSLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFJ3</accession>
    <name>A0A914HFJ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFJ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17057.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17057.t1"/>
        <property type="gene ID" value="Gr19_v10_g17057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17057.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38331" checksum="4D3C4D1724DA7F31" modified="2023-02-22" version="1">MLNNLNEMPNSSPNMILRGSLCTCELFSVPDLRPQPNFPAMNLARRAPALFNFKKNVLAVAGCSGPGQHLTEIESIQFDGKNLEGNWKICEMKAPNAFSCAAFCQFADDTAFAFGGFDGRHCTRQSLLLRPSLPYPSSVHSLEPLPYPSSVHSLEPLPYPSSVHSLEPLPYGVKNGVAVVARDCGESKGRLLWLVGGWDGHRTLKTVFEYAFPEQNCSLKHILPYPIEGHSIAKSSVVAPQKAFIAGGFDGIGLRADFLAMDLRTGAVELIAGIALEKPRENHCSVIFGDGQGNEWLAIIGGWDGHKALSDWEIFELLPDAPWLRRTDIGPWGEKPATLATARNRPATILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFU4</accession>
    <name>A0A914HFU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17123.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17123.t2"/>
        <property type="gene ID" value="Gr19_v10_g17123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17123.t2"/>
        </source>
    </evidence>
    <sequence length="82" mass="9476" checksum="AD430AEDD9EFE77B" modified="2023-02-22" version="1">MPNDTRKWGKNCTKVYDAALANVDAILERLELFFYSRQLVEENFHPTKKKVLEPNAQVALRFLIQQNVGVVPRSSDPPMKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG91</accession>
    <name>A0A914HG91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HG91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17224.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17224.t2"/>
        <property type="gene ID" value="Gr19_v10_g17224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF44">
        <property type="entry name" value="SIX HOMEOBOX 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="173"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17224.t2"/>
        </source>
    </evidence>
    <sequence length="345" mass="39789" checksum="4903852502B856D4" modified="2023-02-22" version="1">MLQTTAGPMFYDSYGRVCRPNSPSQRSPSAEHPRSRVPPQLDDVSLFSADQVACICQCLENCADFSGLTFFVERIEKYCGLLANHPARDILHRAKALSLFHCRQFGELYAFIQHSQFVPGDHSLLQRLWNEAHYAEVEHLRGKQLDPVSRYRIRKKNGFPRSIWDGEGTSYCFKKSARQILRETYRRHNMPSQEEKVRLARKTQLSVVQVSNWFKNQRQRARQHRLQQKNDQKIIICSSTESDGTEGEQQNIARRDGGEGRWDDPPAEVPLPGAKMPFLRCTPSSSHFHPSIGHLAVGVVNEAAMKWGRRGRRRNCRRAEEQKGEEEFGGRKEENAAREELKREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGB4</accession>
    <name>A0A914HGB4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit eta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g16360.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16360.t1"/>
        <property type="gene ID" value="Gr19_v10_g16360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="539"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="881"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="556"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16360.t1"/>
        </source>
    </evidence>
    <sequence length="1443" mass="159508" checksum="652607CC9C897F68" modified="2023-02-22" version="1">MVATNSVGNAGELLFAALDGGDMEESNEILDGHPESVDARDEELRVPLHYAADCADLETFQRILNKFGFTPLLVSVMAGNLEVLESLIEQGAQLDLLDRDGHSAVHWAVVCGQLDVLIALQRHGAPIALADVHGAHPLHYATVRSALEEEVPPYRAEAVLHVLLRHGAQLECADVDGRTPLLWAASDGNLPAFRSLVQKGANRFSVDPRPTRRSPLCRKPRIRAMTVDAKDRNSDTPLFYAATFGHCECAKLLLDKGANDKRIRTAAHCAAAKGQLRVLKLLRQFGASFSLQNYRGDLPFHEAVQTGLKDVIEWFLDIEPNFVSAPNFCGRAPLHLAASKGNIELVVLLCTRGAQINALMMHKGQLLTPLDVAKSRGHELVIDYLSGKHGALTAAGVSPEGRDFQRLSIEERLKTAKLRKMHVELMAYEEVTREGTQSLLERGHSVRTSKKARRADRREMVDAYTTMSRRSSSASAGSFHFPKKVPRTTSTTDLLALSPSFYAQRGGGNGRGKGQVMQNETERAEMEKTIQRIVQEELQNTANWESGAGQDSVENEESKRRRESVESEKIAEQEERESEREGGGQNIVPTPAAAVAEFRAKHSARGNKVRTPASDHEEEDVHRKIGGRVRLKMEDEGVRVGEEKGTRQQRILRRMTPRGAQRADEDEEDVGEVTELHILEQGLSPPVSQQPIGRMAQFANNTNHHAPRSSITRRYIHEKAIFDELTHLKRMQLQYRRVSEAVLVRSLVQNFCRMHSINPAHFRRVHTFHQWEKFLYDQLKLIYLEERDRISAAAIIASQRAAAAAGAVGTRPAVLYSAQQRVFAGTASAAIGGTAPMGALILRKFDSRVLPRTDPLEERMHELNRIYGSGSSSRNSVTLTATHSIAAQPLADTQRRRRRREKKEETKDGKTMSVPIVLLREGTQSKQGRDQILSNISACCAVADNIRTTLGPRGLDKLLVDRKGQTTISNDGATILKQLDIVFPAAVMMCDIAKSQDAEVGDGTTSVVLLAAEFLKSVKPFVEEGVSPQLVIKAFNAASQEAIKKLHELAIKVQGTEESREMLIRCAATTLSSKLLKQERHHFASMVVSAVDHLDVDLPLNMIGIKKVSGGSIKDSRLVTGVAFKKAFSYAGFEMQPKHYKEPLIAVLNIELELKAERDNAELRIGSVADYQEVVNAEWTILYQKLEKIHESGAKIVLSKLPIGDVATQWFADRDMFCAGRIQEDDLGRVMAACGGSTLTTVSQIDKSVLGKCAEFYEQQVGSERYNFFIDGSKEKSCTLLLRGGAEQFIAETERSLHDAIMIVRRAKKNDSIVAGGGAIEMELSKHLLALANSREMKDQFFWKAYAKAFEMIPQQLCQNAGVDSISTLGELRAAHQRGEKWAGVDIQRECVADNMDGCVWEPALVKENAIVSATEAACLVLSIDQTIKNPKNKNEMPGLPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGW4</accession>
    <name>A0A914HGW4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGW4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17063.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17063.t1"/>
        <property type="gene ID" value="Gr19_v10_g17063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17063.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8030" checksum="464252BB5D42FD4D" modified="2023-02-22" version="1">MPAQFPCNLQRNIIFYSRHCHTQSGKLFTFDEEGEGSRLNIYTFMASPHVEHKRVIVEGATVVMRSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH11</accession>
    <name>A0A914HH11_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17421.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17421.t1"/>
        <property type="gene ID" value="Gr19_v10_g17421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17421.t1"/>
        </source>
    </evidence>
    <sequence length="434" mass="51091" checksum="2B3B5997A4293C32" modified="2023-02-22" version="1">MSQQQKMLEERTRELETIRRQLAALEREKFPPDALTLLAQKRELHAQLEREEMEKHELLAQINALVGEMAQLRANANETEEAEELSTELEQLKLDFAKKEAELQRTKAAGEEAQRRQRIDRLERERLEEELRERDELLRELTETSDELGRTLNETSNELKKLKEELMEEKEKCRKGQEARKDNEQRSRTEKEAQEKELEKRKNELETAKEELEEEKKEWRAKEKAVGTIGEEKQKALEAERERVLELGKRIAEMETLLEEREKRAEEERAQADEQRRRTDEALAAETERAIKLAKRVEELEKNEAKTAEDGARELDAEVERLENDKARLAAELLAEARRAERSERELETFKQSLEAKEAAAAEERTRELNFRPQQQQPTPPMANPRKSQDQDENDELARLGAELDKHRRLVTVLRKKLQQKELEKKRGDGENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHQ6</accession>
    <name>A0A914HHQ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHQ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17050.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17050.t2"/>
        <property type="gene ID" value="Gr19_v10_g17050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17050.t2"/>
        </source>
    </evidence>
    <sequence length="416" mass="47385" checksum="BEA26F3A22A0D4D7" modified="2023-02-22" version="1">MGLRAREGCLINNHLKTWKAMGPRAREGCLRPPTDKTWEAMGPRAREGCLINNHLKTWEAIGPRAREGCLINNHLKTWEAMGPRAQEGCLINNHLKTWEAMGPRAREGCLRPPTDKTWEAMGPRAREGCLINNHLKTWEAMGPRAREGFFLSAKTFAAPNDVKSKQLLTFSPIVTELAQKIVEECLDEYKKMMAKLTTSNGRQPFNTNWLPNVKCAARGTVEWHNSAVVTARIQHEFEAVDKIWARKMLTALAGNCKNYILDAGESRANRTNAFQTAVKAIRNVQLQPPNSNRNQTEIDETCAILYTQNPGKNLCMFAKKLAYLTKFNQMFGIPTNSFGCWLWPLNSNRNNAAAAAEECLDCLDIMRHVYEDELRKVTKWLWGKVKRQFLEKFAFDRQARDVENAIKMMFEKGKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHV9</accession>
    <name>A0A914HHV9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHV9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16778.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16778.t2"/>
        <property type="gene ID" value="Gr19_v10_g16778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16778.t2"/>
        </source>
    </evidence>
    <sequence length="167" mass="18982" checksum="93B2803BE824385F" modified="2023-02-22" version="1">MRKKKKRFLEHSAWRLDFGGGLPKTNKMPPPPPPPQAKQQQQQQRQQQEQPVEEEQQPQDPSALKIVVANVDVGQAEGNDRRTKNGKFTLAQLRATDGICPLQNGTNQFDSQKLMTNFGTPRDVKGKHLKRIWELEFPEEAADYQQQMPPVNAAPQQQQPQAQPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIP3</accession>
    <name>A0A914HIP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1819.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1819.t1"/>
        <property type="gene ID" value="Gr19_v10_g1819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="289"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1819.t1"/>
        </source>
    </evidence>
    <sequence length="428" mass="47595" checksum="E44570632318514A" modified="2023-02-22" version="1">MPKPNSLVGRIKHLLDTGNGADVHFLVGEGTEKEILPAHKLILTAASDVFEAMFRFDAQNAKNAAAAGTALSEEIKPVEVPDVEVEAFKAMLSFIYADDVSGLNGDNAIAVLYAAKKYDLAELVVSCVNFLPIWKLRNVFLAFDQARFLGEKKANILLRSEAFLNIGQKLLCEILDRDELMIRKELTIWNAALHWADEKCCQNGKERSGENRRAMLGSALFKIRFPLISQGDFSDNIVPSGVLTRDELNSVYLHHSHPDAALSELYSLQFPTNGRIVTKSDDDDPFKLEGNIMLKLEKVSEFARADGNSRRLSDAVYIRGLPWKILAIPRTLARSPIKHLGFFLQCNGENTDPSWSCAGSATLRIVSQNEDHTGKFLSHIFHSEENDWGYAFMTFEDLMAPDNGCYDAKNDTVILEAEVTADEPIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJD0</accession>
    <name>A0A914HJD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1717.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1717.t1"/>
        <property type="gene ID" value="Gr19_v10_g1717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1717.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8236" checksum="94DB6F4F0A865127" modified="2023-02-22" version="1">MIRKKKKPSTEGEQFNCLLSKNAQLTAGLMHLFTCNFEEANSRRNIKNLGEWHKLFFLAYGQALAQICTGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKW1</accession>
    <name>A0A914HKW1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2263.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2263.t1"/>
        <property type="gene ID" value="Gr19_v10_g2263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037363802" description="polynucleotide adenylyltransferase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="12">
        <location>
            <begin position="1084"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2263.t1"/>
        </source>
    </evidence>
    <sequence length="1363" mass="156351" checksum="AD30FCEE1B004FD1" modified="2023-02-22" version="1">MKIHLLILLAQFDQIIAAPGKGIVKTICSWYNVCRFDLNPIDGMQHIMMDNLYTDYFLDNSATDQRIIMLKIAICTHVYMMRWTIEQHMDKLCKMRKFRPVPDGQDDADDGAGTSNKARENAYNWLSRELTLIRRKVVVKKHETQYEMPQSNCDSTHFHSLVTMCFLLKFKFQLSHTLRATTNFGIFANENVSCESAKSIRQSVEMNLESIREWMLSDLVYFFKRRPKLVQYFDELQKRNNESEIIENRQKFVALLGTARTALFCDIHFENFEFFAASTHEKNTFYALLYKEFLKQNNKLGKWRAKIMLDKYLYSEWFKTFYNEMKATLEGQSDEKLHKMAILADLQHFWDCFGNDFWLNEKNIREAIGQFVRKNGGKMSKLKQPFLVQCQPLDWVKCHQNEKDLPTLWENGPEDVSLFRAMTICTKEIKVNNKQANIVENDDNFLFVTKFKFLQCVEKGLKNNARRDDIVAKLHFEKIEELLDCNDGFIDFTTLLSENKQSLKELLDSDGFKKVDELLKKNFEYFSPVDNLSSESSDANDFLDANDEDFDGQLIDSPRGKIVDSPKGQLGDSPRGQLIDSPRGQIGDSPRGQIGDSPRGQMTSERQLDDSPSPKGQFRDIISFDPSSSKRQLDDISSSTYYTCITMLKQIGIETFSDLLNNFLLGNFYKNYLENKFDGKCVVYLHISMFVRTIEAKLKTKTTHFEKNAKWKSFKDKTFVEEPQFLANKLFVVQNNLDELAAVGTSTSTGCLEKAMEMLNNVKMRRVGKDIDDQFENILPLINHQNDDDVIRITQFGSYKMETFKNVLIQLHNHIFASLCAEKFAEIPSENEQNAKLLNLEKLNFIFNEQEMLLKKVEAMNIVLKQQQIGNPIICESNQYNLIRTNPANRQNDVHLSNGIVHFITPFCASEEKNLKIDKIKRQIASILKKWVKKVANFKQPLLLTNGSHLMSSDLDSSDLDLICVVPDQIHLFTFYGEKDTTLYSMLRKELSGAKLNWIAGKVPLIRIEFGPIEVDLLLVPLPIKYLTGTAAAAAAAAAAAAAAAQLEGDQVIKDICNEKGIYSLAGYRSSKFQLSLVNDKQLFAYFLKSIKVWAKNRLIYSGIFGYFNGATLTVMVTKICALFPFAPLAYLLYKFFQIYSKWNWPVDPVLLDKLSKDSLSFLVNGWPPKFGESSMTVITPKFPEQNAAFNVNKFTLRTIVEEINTANQILSENVQKWARLFEEVKYAKEFAHFAIILCADVDAQRYATNCGFYRCKIRRNLFEWATATNVSPMLAHYQIISQSEEKTICNISDSAASCTFWVVGLTMKNGCDKKLKELPPIYRNDSNSKQFLNSTQMSSSYTNAQSLSNTLNELRASTAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLY0</accession>
    <name>A0A914HLY0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLY0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2000.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2000.t2"/>
        <property type="gene ID" value="Gr19_v10_g2000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2000.t2"/>
        </source>
    </evidence>
    <sequence length="287" mass="32853" checksum="260CF08D6412B925" modified="2023-02-22" version="1">MPQNKDDCGKGGKGYVVWDSETSQDKIYKGDQKEHVINYISARDLGQGHYGASVIAIKYLEWRSKKDNVDIKHAGNGREEQVGKYKLNEYIERLGAAEARLIGGRAAHICMMKHRSAWLSCWMLRKFGFLPQLILPPLYGAAIQPHPSQLRHSLLISFFEVIGGKVRIPKLPPYGPSTSTTEEQRKLISEIRERFSNLESKKIYAVAHYLDPRFKDQFVPNRLEFASKIHSWIKSDILLPTNSGEMKGPHLQKRSAVISLRPARINLLLEKRQQRAQVNRLRTLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM98</accession>
    <name>A0A914HM98_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM98"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2095.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2095.t1"/>
        <property type="gene ID" value="Gr19_v10_g2095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2095.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13446" checksum="09296B89C63CF591" modified="2023-02-22" version="1">MRGANMQFTLPPRSGGLKCKEENLNAAGCAKAKLKVWGWSKHNSCSAVSAKVGKVANSAPTTTTDKPTITKDKPTTTKDKPTTTTDKSTTTTEKPTTTIAEANLGARHEIAMCGGGMLMAIGLVRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMF6</accession>
    <name>A0A914HMF6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2136.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2136.t1"/>
        <property type="gene ID" value="Gr19_v10_g2136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2136.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11779" checksum="6201374001B173A4" modified="2023-02-22" version="1">MFPAGPKKKFCSICRNTLEVFDDKLTTERHTVHKKCFKCGICDAPLLIGKCAMDDVLYHQFGPMWFCAAHKMLGSGEKYELLKKAGKAKEAKEHIPQEFIASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMR5</accession>
    <name>A0A914HMR5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Luc7-like protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HMR5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2739.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2739.t1"/>
        <property type="gene ID" value="Gr19_v10_g2739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2739.t1"/>
        </source>
    </evidence>
    <sequence length="547" mass="62522" checksum="C5D5D327824702B5" modified="2023-02-22" version="1">MASFNEQLKSFFCKSEEQLREASLTGMSAAKVTFIVATILIALMLVIALGLFLRNQQRKKRARERSKGRVIDSDGFAENLKTIATEERTTTSVIGEQQQFGTERVEQKYYPENQFFLLYAFFNFTETQSNYRNSRINPFKSCTLSKSRTGFLSEVTMTAKDQIAAMLNELMGPGRNEDKNLDLNFRDTDVCKFFLAGFCPHDEFVNTKADLGVCRYVHDENLRIAYRKSEHFGKLGYERQFYYFLRRIHDDMMRRIERNKERLALTQGAQNMDEATKKQLEEKAERLEREMGEFVEVAERAGSRGDLEKSQKYVKRAEEVNAELDNVRKLLDPEARQHEVYQAGYKDPNAPKPMRVCEVCGSFLIIGDVQQRIDDHMQGRQHLGYAKITATLAELKVKLRDEITPERTSSRSPVSTSGGGHQRSHRRSRSKSNERKSRRKRSRSGSSRAGGGGGHRRAKRSHSRHRDDVNNKHSAEVASEKSLPAAQHGQQQSSSIGTVQVPYSRRVSGRAAPTVPPHTSHNPDFLAIKSERVFHSYPTLMSRSMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMV9</accession>
    <name>A0A914HMV9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L17, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HMV9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2773.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2773.t1"/>
        <property type="gene ID" value="Gr19_v10_g2773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2773.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="21911" checksum="28B346804DED493F" modified="2023-02-22" version="1">MSTHRLLPSLPRIKVPIGRRPQRLKTPFMQNPRGHMEVLRKLVNRVFREERCEFKYNRAEECRQYVERLIQLGVYRGPDCEYTAEMFRWWFIEQDLIDKMWSIVVPRFAHYPIDESYTDIYRLPTIRLKTRVNKETVFWSRYSIAVLELKENPFPPMAEMEEMRKTNLLEFVKKELRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMY1</accession>
    <name>A0A914HMY1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMY1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2982.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2982.t1"/>
        <property type="gene ID" value="Gr19_v10_g2982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF10">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2982.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24108" checksum="A01204F283083F23" modified="2023-02-22" version="1">MFDRCKNFLVAGNEVSYYEVLGVNKRATTDEINKKYKKIMLEFHTDKNPDGAVMSQVFSKAKETLTDPRKRAIYDGQRGYSSYSSSSSAAGGSQHSWWTGAANMDYEMSKPPEFPTFTAMLKESNCEQMANQLKELADYVVADGDPPAGKLFVGNGHHRAPALRYIPSSNRDNFCLVCGTKGMPLDNVCYCIAAKANCHCYPKCCRTTLKDRGKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN02</accession>
    <name>A0A914HN02_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HN02"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2278.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2278.t1"/>
        <property type="gene ID" value="Gr19_v10_g2278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2278.t1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60485" checksum="7A02341B364F2F22" modified="2023-02-22" version="1">MLGSYFFNMWPPDDIGKRQESGTMAPCRENSNATKNSGRRTTDDIDYRRFVHMDFSYTNSSECDSASVVPEYWYYAITRHVFFEDGPCEVFRVNVRERMRSPERIGHVQLGGMIGTDRLWLDRSCANFYGICIYPGLAEDGTVTREGASKRCFRGDLAFGPEDGPVRLLRLIRHNNTLQRMDMALAGEPLKIGEWDLCGSEFRWHFHFMSDNEAILLVAESEFNDVTLRMLLCTHVYHLRIDTGRSIAFATKIDFPVPIEQPDNLRVHPASCPVAQSDQIFVYLMEEDSATNNDKHQKQKMLPLFYRVDMQHRCHFYNDANSSWERWDDYSSADSSIPPGKYYFQRDRFDKGLLLLNYLENCYVELHIRPLERRCTFKRFFRAQRSFWPDREGIVFGKTTPDDRLFLLYRSPPVIWPLKLLSFWKLTALLDQNGATGFNNMTINSNEEAQQLFVVNANVCKVWFVCGVYATLVRCAIVLGVQAGGQVKENPVFPVFAIFTALCAKFASKQGEVTEHDPKQSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN69</accession>
    <name>A0A914HN69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PPPDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HN69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2853.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2853.t1"/>
        <property type="gene ID" value="Gr19_v10_g2853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2853.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34581" checksum="ADBA4F2D0A3C5755" modified="2023-02-22" version="1">MYRISQNSSELRTTEDERTTNDSDGGRSSTSSSCANLEEHNRIRLAVYNLHKQLRLYHVGVLVGGKEFHYGIKIGVFACEPKNSGRNFHVRHFNLFRWGIEFMRHVDIVMKKYPLYTEMGVEQLLEVMEELRPRYKWADYNLLNHNCMDFAMEFIRRISAVDLPQGKFFSWTQEIRQPLILVPIRKICETEAWKRTVKVVREKERKRETKRARKAKRKTEKQRKAIEKAQRGGGQQQTEERAESTDKIAAGAADFAGDKCSGEQQHILHRGALGMYITTIKILPVDEADYDKVDKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP02</accession>
    <name>A0A914HP02_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP02"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3302.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3302.t1"/>
        <property type="gene ID" value="Gr19_v10_g3302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3302.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20503" checksum="2BE44B2651C66A65" modified="2023-02-22" version="1">MKAELKRAGFKNSYSYQIDETVAKELGLNFRTLYNWKRKLGQTTPHHNHNEQKKLLKHYYEIKDKNPKMNDEDIAKLLKIGSKTFCTKFVQAADVCWNAPFKAKIRQQYEDWMLHGEKTTTSSGNTRAAPMNIYLNWIYEARTHGFHPIRGQLFQLSYRGVPLAFFFMGDLLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQE2</accession>
    <name>A0A914HQE2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQE2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2930.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2930.t1"/>
        <property type="gene ID" value="Gr19_v10_g2930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037918009" evidence="2">
        <location>
            <begin position="18"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2930.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="35058" checksum="65EE1CA01777E3E1" modified="2023-02-22" version="1">MFLPILLFNVLLVLSESAPWQQKKASFVIKDDEMFKCRDGREGIQIEDAKDLNMWERILIALIIEEAMEKCPNELLPFIEHCNADGKYDESFCILIGLLVRIDADEDKCAEKSEAVDFYANDQRQFNEREQQLNHFLEQFVEERNKKFEDQNEPDRRKGELSANIVEEYQKQQQVEIDGKIGENENSAAISTPGQWKELSDKALEVQMEEWKSLAKFELENKALRAELAHQKLLNAYMVLQTKMEEYQNKQQQADDLIEKLKDTANLFVSSAVDLFPCISLGSSGTKIEANFGPNFQFNIADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR03</accession>
    <name>A0A914HR03_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR03"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3100.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3100.t1"/>
        <property type="gene ID" value="Gr19_v10_g3100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3100.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9408" checksum="A18ED1FD129B6817" modified="2023-02-22" version="1">MLSHITKDGGDRFSAHGSVPDGSVPHGSVPHGSEPARFSAVRFSAHGSVLIINATFQCQDFFPRKKIAMEQNIQIILSSSSPAFLAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRA3</accession>
    <name>A0A914HRA3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3733.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3733.t2"/>
        <property type="gene ID" value="Gr19_v10_g3733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="13">
        <location>
            <begin position="1495"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="14">
        <location>
            <begin position="1618"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="576"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="901"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="530"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="649"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="738"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="999"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1029"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3733.t2"/>
        </source>
    </evidence>
    <sequence length="1634" mass="180935" checksum="2D05265421B7A7F9" modified="2023-02-22" version="1">MIAKISATDERNSNVKAPSERGSPCQHSEMPSTSTNPPPHHQNPTSSCHHNRQQNGGQPHYSHWGEFQKKQIHAWKRLPHPHDPDNDAKCIFRVHGICVEFPEHNTDKVVDPRRPFDPRRAKTGMELQVPDFTLDDEFCTIPPFREIALVGLNDNIDEKFLKELCKKIPSATATKQSQNANNNGHCGAEPFELLIYRHPITGRHMGMALIDFGHRVESEAFIARYNGKTMMGKAVQCYFDPFAYKLGELFKASTDGMELALPMRYKLVFNQHTIEHIRTLLVVKYGIVQAGQTEDKSEGLEKMKTDQDNMDKRKKDKKVVLVFNNSSRRSNGTSSVVALSATPMTAAATIELKTELEQEQQDINRGEDGDGEAAAAQEQRQQNGANAEDGNAVVKKEPTTNHLYVAPSSATSALGGVVGSIKQEVVIPSVPSLSSSPPASATTDKKQQEQQHAISTAASSPKGLQSLPPPRLVNPPLLSSPTKTNHHVHHHNSSGGTTSTQQCFTTTTTTTTSSASTSTSKQLEHTSNGSCSTPTPLTNSSTNSNTISPSSCFLSSPSKGSLESRLAALLHRRSAAANRGGGSSSTSSVPVLNGTSSSAAAEASESTMKVSTVAKKKRDEKKPTTTTSRKDGRTATGAGSSNSNNSSGVKHETTIKRETTEKHRSWETKKKWDDGRHQKWSGGRHHHHYYNNQQQRKQCWEQPTRKQPQSTWPSSSSNTTFYNNNNRDMHRQHHQLRHQQFQRTDTTTTTTQTHTSKMDIFATTIRLTLNLFRTKLMLAVKEDIDRRVAVEAFKMLDKRFEEVEELEARRKKEEEEKQQNNRNGIDAASAVDGAVTTNTPRKAFIPLMLRNGLLDSLFPGAFPSIGKENSGSTSNGLFGMAYAQRIAISSLPQIRRKPVLKMPQDHHHHHHSHHHRWRKDDNRKRKKSISSSGSLLTEDDAETTTITTTKKRRRVELSDDDERMNSGSDRVDDDDEGDDYRSRRRMRSISVESSRRTRSPSTSSSISTATSSTTSSSSSAVASERPSETDEDDVEDEAKEEDVDEFEEHSSDVLAKRILPEASHGIDGVVVDDCLPEAIGGKGAGGVEAEHLVGSKEQKQEEEVADAISAVVVHCTTALPEAESSKVLQRLHGAELRSSKRWPKRTLADEDTVLREYMRNGLELEEIEYLKMAFKELDLADLMANISDTAIQNVRRMPCAGVQTQQPFVWVEPEGICETPPLFPKPYTDAKRPGYVYYYVDAELEGVVPNRTGSARTEGHFTRKRDLEKEQLLAQGIQRRALMRRAAAAAADPLHLRTTISTQDETVARHVSQALKSERAIARSLASAAPAYQLCTSSSTHSMDLCTADASLAAAAVGPSLFARANQLKVVHDQAIAGEEQGTTMRMIMKRRGRRRIVDMNVSTKCSSSSPSPLYPQDQAVHNCTLGVQTYESFGVMVKTRAKPFVLGRGINGDGGGRVCGVVHEGDGAGKEDGTAAQRGGYTTPRAKHSKYRSKMIKFARSRIHGWGLFALESIAQDEMIVEYVGEKIRPEVANVRELAYERQGIGSSYLFRIDDYNVIDATKKGNFARFINHSCQPNCYAKVLMVGGDKRIVIYSKRFIEKGEEITYDYKFPPEETKIPCLCGSAQCRGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSP9</accession>
    <name>A0A914HSP9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSP9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3866.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3866.t1"/>
        <property type="gene ID" value="Gr19_v10_g3866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3866.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11949" checksum="59B8B6DA4C72F364" modified="2023-02-22" version="1">MDFSPSSRPPTTPALGLPKLWLNGCLGNASESINFIIRFLHSPIYGIEPFELKNNLTGEQLTLRQIDEDYWLLVRCPIGREEDKWTNGNGTVNGIAPSLTSKTGTSATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTI1</accession>
    <name>A0A914HTI1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTI1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3826.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3826.t1"/>
        <property type="gene ID" value="Gr19_v10_g3826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF372">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP76A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037248851" evidence="1">
        <location>
            <begin position="19"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="391"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3826.t1"/>
        </source>
    </evidence>
    <sequence length="548" mass="60080" checksum="AAA65C629459E594" modified="2023-02-22" version="1">MVLHFNLALTITVLQVFGIQFNGCNANQQSKAFGGLKFNAKELCRAIEGTSFHAQCLLSEVVKQKGFIPRNLRPPWLNSSLFEDNKLPADKATGDGCYACYKGTKASNGVNPGEEYCACTYKKQALNKKFGKIFGTFDFAGTTCIQNFHKMALMPKCGSDYYDHVKHCAMVHFYDNDPEKEPRNFDHKSTLVLLDGCIIAGGASHKNCTANVNIAFEQPQRSFFYGNCDAETKTVFESTIEVKASSAAASDKSSADKNNVTNAASSPFAFPVEFKHRICKGLFGSDVDDAFENITITISGDCGTKSFKFPTLEFEKGRVQEMRGLQLDLQGNALQWRDSLGGYAFAKEARLMWQPSELKSLNAFGLVDVALMYPNLDLNRSQNLDLNPVGQAEFSVDLLKAVYRNPTEGTSVKNTVLSPLSAAIALAMAYAGARGQTAAEFGKVLAGDSSDSTLHINFGKFLQEIASNKTDEELKKQNNFQPDGPPPEFKLRIANRIYLANTFNVLDAFKSVINTHYGGNFESIDFAQSAAAAEAKIELKIISGPDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUL9</accession>
    <name>A0A914HUL9_GLORO</name>
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        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUL9"/>
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        <property type="gene ID" value="Gr19_v10_g4630"/>
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        <property type="entry name" value="SPRY_RanBP_like"/>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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            <begin position="43"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4630.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26395" checksum="8EEDE4FFBCE47964" modified="2023-02-22" version="1">MEKYQKQQQQNIDEFTEKLKSLNAVQEAKNTLQEKIVKMEKCQNKQQLNIVDMQKTVAALREIGITPQNRWDSAARHKDLTLIAPNQLIWRSVLAEQPIPKKDLGIFYYEVKMSGKAGSVLIGLGTKPTPFNERVGDGSYSYESNGTFWGHAVERCLHFNGRPFIMDKPKFGVGDVVGCGVNLANRQIFHTKNGERLENTGLFVDAAELFPCVTLYNSGLKIGANFGPNFEHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW61</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <scope>IDENTIFICATION</scope>
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            <begin position="68"/>
            <end position="111"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5223.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12566" checksum="D2D1B9973A86EADB" modified="2023-02-22" version="1">MRAALCSQGRERSSVMQTLRFYTRRVFGLDVSVPRPADFLSSGPEIPNDYRARQDWRGFHARTHNFDANALRRPPGEQLPFQPQPPPVSNSGPVKYTDLNIGRNIDQELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWJ7</accession>
    <name>A0A914HWJ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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        <property type="protein sequence ID" value="Gr19_v10_g5140.t4"/>
        <property type="gene ID" value="Gr19_v10_g5140"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cilium"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:pseudouridine synthase activity"/>
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    </dbReference>
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        <property type="term" value="P:pseudouridine synthesis"/>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
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    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
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        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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            <end position="1781"/>
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        <location>
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            <end position="1524"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5140.t4"/>
        </source>
    </evidence>
    <sequence length="2913" mass="325084" checksum="A1D991325F689EF3" modified="2023-02-22" version="1">MDTRPPSARPSTRQQPQRPGTASVRRPKTAGRNSERPLSSTGRPLLPQQTPISANRPKSRMGLAGGEMIGAGGHRPATGTVGASDGNGAPLPKSATDSLRSSSRRGLHSAASRHNAMFPAGGSVPVPSVGGPSMQQRPITQQGISGAKAVVPGSRMGSRLGTAMRGRMVADKSYFIGLLNNQLNALETEIVSLGLELQKAEKGRENLLAYEQRAEEQANELKQLQGGLADYNLIISRQNTNSDLRMLENEVVEANRINREMVATVEGLFRERKVREEAMHELEQRIERMKAENTLKLSDMEREVKEEFKRVSAEAETLAGDLSKRQTELEELCRRKEEMDLALVNSPLKKQAMMLEEQLQELRERRMAILAELNSEETPEVQREHFAQRIQRDNEEISHMQTQLQEMKERLAQSQEELQEFHNEFELLAGDKSEKFRELKNRELQMDSFLESFELSKSQRESQIRALSAQIVRQLQLISLNCRHLEMVMTNVSGLDESVLALGSAGVSAAELQELHVRLQEELITLGQNETLLRTELASKRSKQTEIDSIGRMANSETLREELGTKSREMEAKRAQLEEELTRVDAELAMFREQRGAEQRRLGQNAQIAKSHAQLVAHPRVLFLDEDWPVGKELEVKICDGTEKDELNNGGQQKAIPFEMHLVRRGNENGELADQFSVVPVNESCFTLMLNKQLEADLPLAATVEGPLTPVSPSFSLLFERNDTGDRASLQVELVDVNDNPPRFLGGPFPVELIVPEDSSPGLLLHRLEVVDPDGGIGGICRFSFDRTTNGNGTEEFELFTLDSQQCQWSRCSANLRLNKRMAKGDLAKVRVKARDGAGLTTRANEAVAELEVIVLGANDGGWKAGLTNEDKVEGLGVGREETEETGEEDNNGMDSSLKVTAMSTETSREAYSPLSSPSRRPPPSSSPRSPPAFRTFVVNNLSEDAPDGLELLRLTLPSDQSFHFVMLNSNGLRMLANCSVRVNAPLEVQKRGEMVAEVRRVEDDLPVVVIRVQIWSMISQFQEWMDREIPPNGQIRVEMATGRWVRVLTLPEELYKYAHPTRKKRKGEAPEGKGEAPGRKGEAPEGKGEAPGRKGEAPEGKGEAPGRKGEAPEGKGEAPERKGKAPEGKGETPEGKGKAPVRKGEAPEGKGEAPERKGKAPEGKGETPERKGQAPEGKGETPERKGQAPEGKGEAPEGKGETPEGKGEAPEGKGKAPARLGRSLCVRLPVREWRLQIHWPPEGFLRLTFPENAPLPPVLLQPNVSIYYPPLASPTFSLQNDFNDRAKFYVDPNSGKLSLANRSRVFDFERERFFSVGVSVCVTTAGRRSGCQQIVLQMDVLDSNDHCPQFEDPQANQTETIREDSQPDLTLPIVHFPPAIDADGTDQWRSICYRLVNSFGQTFAIPNPEKAELFLLKALDRETVSSYALEIEAEDCPWTRQRCFPSFSPSPSFSPSPSFSRSPSFSPSSSFSPSPSFSPSPSFSPSPSFSTAASLSSTPPSPSSSILRLSISVSDVNDNPPRFIRRHFFAPLIDLAVKPGDALVRLRATDADQGDQQKGQLKFMWGERTVQTEVDPIPIAVSPFRLNQTNGELSIRNDFDETMSFQRTSFTFRVRVQDSGAKHEDQASVTISILDTSVHLAQLNFSADSTLLDDGRDLLEQLLSIAIGHEWRVLNQKLSRCGGNCSRMSAYFLAKGTFQPIGAERALNELRTAAKKGNEEQRRALNALRDRFGLTMADNAKIPGHFPSGGRSHRFPNIPLVLLSSSFVLISLILFVLFVCRRRRGKSTRRERVHALRLVGPPAGSALCWWEAKGETIAEPATTTSTRSFSRQRRPMGEHFVPVPHIFNGDGVLTNSAASVGTLPLSIPRPLLLETAITFFSLTERENGPRRVNGSEIRGSVCGARKLSNPFIQQSWQKQSDQKQLTTAEPFQISTHNDAKMAAVLFCDVLGALCILLNAFVILALLRNRRRVLVNVFYVLVLHCAVVDLIRGACLIAWGMPHLLIHTMRSIDDRLFALKINQFTLVILRSCNLLTIFNLLVFTTNEFIVIKYPLHYRRYFCRRTVVFVLAMCWFVSLLFGIGSVFANFLESVHNVLVEMNATVSPPFEQNEWRKAGDGEEEDEDELPPKGVTGSPFEQNEWRKAGDGEEEDEDGLPPKGPNGVQRRQMAGLSINGLFMLMIFVLCYVCLFTVLICYGKILKTIRQFQRHGGDGRRRVLTNSAVGSQKKPRNRTAGGSIYHKRSVHQQRNHHNQQKGGCQGVVGGGEQLPTEVQSSSNRMDSLSKKVSIPGTPQSRGSRTNCGRCPNCEANPETEIGRSRRCNSHRKWRSHLMSRHKYLIVIGTVLFVDILFLFPYSGIQMVALLHLNNLLATSHLTTLIRWCLQILIGVHSVCQPLGSSAGGSIFGGATAGTISRSAKSIGTMKAPILGGNENGDTDEQPPAKTKRSIVLRTVVSQGMPPRGIMKLAEAGERQEEMTNWANPSVDGQQMLLITQRRRWRRNLSLLCKEEGEELELFLAKEYRRRGVEEHGKGESGQEESGERTRKGGCWKRKASTDQKDFDRLQRRAVICESFSSGFATMAQGLRKRAFRSNQNIHSQQNRCKSARHPFTYSGEISLIISMNAGYAGAVELLRIHPVALGFHPSYHVAYRLVCKKQKLYSFNFGRYVYRLRVLSPEQSRNYPDRFFTQACHLIPNKTSLDDIAEYHYSWTIPPTFSVERAQIACDLLMKPGQNFASFYFHQLRLRKMDKQYKSVTRRRQLSLLQIEKGEPYHFADDEAQFYNLNFIAHGFMRQQIRRMVSLIVNIACDTSGSDPRRIYEFLLRDPDPVRFHEARLVPAPSSGLFLTDVVYDPKMFTKPMPEYLSAWDLDDCEEQVVSECADDEPLEGENTKREEENGESENELDKKYALESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWJ9</accession>
    <name>A0A914HWJ9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWJ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5323.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5323.t2"/>
        <property type="gene ID" value="Gr19_v10_g5323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="4">
        <location>
            <begin position="54"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5323.t2"/>
        </source>
    </evidence>
    <sequence length="274" mass="31639" checksum="BD73CADA59858AB4" modified="2023-02-22" version="1">MWTTESPAKRHFNREESIDIFRSILNLDRMIHIFPSFYQTSLARMKGKTNMPLEAVLALVHMVKARQQELRNHTKLDAASGWTVRNQTWHEITTELNIRYGRELTVDQCMKKLLNIKSMTRYKLEDQERKRKRPGMEQFEVKLTPAEREYIRLFYHGAPPNPPVPGSASWEHIQMLLGGDLPMQSFSLPSTGRESNGGRVDGISLLKDEFLGEEDEVFEIGDDEGEDSLPDERPSQIESVAQTSTALRGQRHLKRGKWPNYVKFAFLVGLKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWK4</accession>
    <name>A0A914HWK4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Matrix-remodeling-associated protein 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWK4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5327.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5327.t1"/>
        <property type="gene ID" value="Gr19_v10_g5327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026622">
        <property type="entry name" value="Mxra7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057534">
        <property type="entry name" value="MXRA7_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21845:SF2">
        <property type="entry name" value="MATRIX-REMODELING-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21845">
        <property type="entry name" value="TRANSMEMBRANE ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25473">
        <property type="entry name" value="MXRA7_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Matrix-remodeling-associated protein 7 helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5327.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28699" checksum="43D3F508A259F2FC" modified="2023-02-22" version="1">MFPSDDFVPSDPRPSTVWEALRHALTNRRLIAMYGLTFVLAVAIPLIVTFAVRKWRERNIRPKLKERAEADEHLSNQTTGTFNKAILNSLHHFEMRHEKSDKTNFSIDKLCWTPSANVENEQQKNEEEKEEEKEEEKEEEKEEEKKTLLEKEEGKKKRKQRKKYKDPDPETAEGLKKLTEKGLHGKLATAQLRAKTQLLEEQMSDEDREKDQLEAIFKLMEAQKEKFGINDKEELVEQLKMYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX89</accession>
    <name>A0A914HX89_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4980.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4980.t1"/>
        <property type="gene ID" value="Gr19_v10_g4980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056643">
        <property type="entry name" value="DUF7741"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24888">
        <property type="entry name" value="DUF7741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="DUF7741" evidence="6">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="795"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="852"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4980.t1"/>
        </source>
    </evidence>
    <sequence length="1613" mass="173627" checksum="DFF802E4578A950A" modified="2023-02-22" version="1">MLLPTINGVESANVHCYIGGGISPTNGSTLSFQNICVGNGSCFLIIANDYTWSAGCNSPYPASANVTFSNATDPYCPTNVTAPTFCRCGTNFCNTPNNPGFLSALNRTLSNIVKPADPGNLTCFECGSPYVNNLDGTRSVAPFNVTCDGSKFCTGKYCVTRKSQYPRSFCATSWEDPKAVQCQKVNEPYDAQECICTRNFCNYPYDPDNPPPTTTTTTTTTTTATTTTTVPPSPWQCFSNCSLSQLTLSPGISTSTDFIPSPTVSNVSAGCAQLMVTCQAQTPRSIIAFGGQGTLRAFRPNFTRVDSLLYCIKNNAGSMWTRFGTSEDSNAMITVSEVHCNKTLDQTVPVSNRTTNSTGGLLAVTPWQCQTPIPTPTNNGSFYGGTPGCAKMMITCNGTSSVVAVAFGRMGRLLSPSDPKIRSDALLYCLNNNGSLMWTRFGTSEDPNAMLQPVTEAHCDVITPPVTTTTTTTTTTAVPAVTTTTPTSATMTTTAVATTTAKGDSSVPPSPWQCAVGCNASQLKLGFGPDNGLSVSYWPFVAPAGCAKFMFICNSPSPMSVVGFGSLGNLSAQIPPYNHTEALLYCIQNGTSLLWTRFGTTKDPNALLQPVTEVRCMREPTTTSTPPPTTTTPPSTPPPTTLPPTTTTPPSTPPPTTLPPTTTTPPSTPPPTTLPPTTTTPPSTPPPTTLPPTTTTPPSTPPPTTLPPTTTTPPSTPPPTTLPPTTTTPPSTPPPTTLPPTTTTPPSTPPTTLPPTTTTPPSTPPPTTLPPTTTTPPSTPPPTTLPPTTTTPPLTTTPPSTPPPTTLPPATTTPPSIPPPTTLPPTTTTPLSTPPPTTTTPPSATTTIPPTTTKPPSPSPTTTPPATPPPTATTPPPTTTTLPSATTTTIPPTTIPPSTPSSAITTTTPPPTPPTTTSAYVITCPDGRQFGPNELAVYMGQILKQTILGTYKNAAGNAAVDSYQDGINTHICNYISGNGGRKRKQSKSNKTSKLNIFVSSPTARWPNQTTKTANHNQFLFICRARIVPMPSMQMLPAAILFHLFAVSAASHSLPPVVANTNYGPLRGFVHFLGDSSESVDVFLGVPYAAPPVEALRFEKPIPPQKWDDIRPAVEPAPACVPHARPFDGTSRAFAEDCLYLNLICPHKKNENASQLSPVLVIIHGGGFEIGSAHQYDFEDIGEKFVRRGIMVVVVQYRLGIFGFASSGDKTMPGNLGLWDLLAMLRWLRSEAKAFGGDAKRVTLLGFSAGSAAISALGMCPFARDLFQQAIQMSGSILAQTKTGAPVANETKILAQQLNCPTDESLELKECLREKTIDELHEAMEKIGPTRSDVNFCKFGPRFDGHFFPRDFPELIQESPPKRTILGFSQLESLIYTLLHLRNDTLTQYVVPKQKIATYGRVDFEAFVRDVVAKDKYFGQKAKQIQEEIIKFFGEEYEVPKKKDNAFWLQRYSLVLTDLHYIMPCVWESRLKLNLGWPIWLYENAYFDPSKMPDHVPVHAPFHGSDHDLMFINPSEKHLKLTEKSKQIVKVLVDVYANFVLKGQPQSELLVKWKMATLEEPMRHLFIDGPKPTMKETMELRRLKFWHTLTETHSEYNLIRGTFGHPTTGEHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXQ7</accession>
    <name>A0A914HXQ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXQ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5001.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5001.t1"/>
        <property type="gene ID" value="Gr19_v10_g5001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037088589" evidence="1">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5001.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8515" checksum="65A32BF40122B3A1" modified="2023-02-22" version="1">MNAKLLLLLTISLAMLSTSPSTAEEANFIRTRRNLSSACHNECAKECVRHPGFEGECWPHCMKYCTDYGTKEGLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYM9</accession>
    <name>A0A914HYM9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPGRIP1 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g5691.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5691.t2"/>
        <property type="gene ID" value="Gr19_v10_g5691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021656">
        <property type="entry name" value="C2-C2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF1">
        <property type="entry name" value="PROTEIN FANTOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11618">
        <property type="entry name" value="C2-C2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="790"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1161"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="552"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1224"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1340"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1368"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1382"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5691.t2"/>
        </source>
    </evidence>
    <sequence length="1614" mass="182017" checksum="1E74F307975114DA" modified="2023-02-22" version="1">MSGGRPHNNKHPPDHRLFQITKSDKISARNGLPPAFSVPGFMSAARTPIERWSREELEDRFHSVAENLSAFKQKNNRLERDVKILNGRIGGRNQQRATLPNGLPPPQKDELDDLHRTNQLMAQKLKVLKHQLLNYTKINSTTLASRYRPTTTGQQQQPKNRQGRRPQSAVVRSSANQLATSANRTIADAVAAVDQPKPERTVEANLIGQQNCDKKRRPISQPAAIDEMRGFVENDAVVDFEDISHEIEITTDRSSRNIRLQQQNGGIGNELKEKLREMQRQNRKVTDENEELRFSLEKNEQRLSTLRREYDRTAQELSQSQRELRSQSDLLSSSQEDSHRRAEGSARGAEIADRELAIVREECRALRSAHERLVKKSLEQENSGKAALEELMRLRGKLQQSETENELDTAERETEIQRLRRENTILRETREKEMDDILGKSGKEETNQQTLQPTNEQKRVTQNDSTVNEPKENVKIIQNQRNGGEMLLNKLFSDVLGIVDSHLDSHNKTIDGGAHFPIGDGNSGERWQKLYEDVYFELDKVRKLLLSEHKINVQLKEEKRQIETELDFAKTKCEKQLAELRGELGERGKQIAVLENELEWVAKSGQIRHTVLSASTQKKASPDDYSEKSASAIEPTELTLQISKIVLTEEAIRQAQNPCPMLFLAIEFFDFETQTTKVMNGPEAIFDFTTMFEAPISDLFIHYIQTEGMEVELYSVAEGLNHELWSKAQIPLKKLLSTQTPTQFHGQLKFCVMNCDEKQQPLLLATAFYSMQVPFSLLRALNAQRRRMVASAMIPIGKRDGRLDEACNELLVHIHRCTGIDKLKGVVTTTTTVNKKAQKLAPPSTYVAYEFFNFPVHMTRTVRESANPVFDDWQTWKLPADSEAVHKYLKEKELSFYLIDEGSESLSPDKLSAKAQALGSIHLPLFPLARNHKIRGTFPLMDRADDESIASEASIDVSICWKFAYVFDGFEDLKIEEKTQLKKFVPLTDKNVPKEEVAREEAQKKQKDGVPEMPEQALPGRQQMSKEQKALERIDIKQLDLIETKGRQFSAGSIQSAGSSEDDQSREEMTEEELRRRLLLMPEPSKTFVGEMENKFETIIESGRQALEHKIMNVQENSQVEARTKEAGQSQILEPINVVVSPKSSSSSATVIIDAEKTLERTTSDEISEDLLKEGSSSAEAEAENDEQEDEDARSIRSDATYTAEGPLGPIEMDEPQVKRIEQPDEELMVIQDEDLEGRMGQIDGQQNDEDDGAEQKSSAQTTIPPVPARRSLLGPLQPIITPQGRQLKKHPAPLPPPMPELLTSRKAVEFAEPLHFSIPPSDVSSTSFAEDVTLGSGRSSNSSAEADGSSSSASNATPRNGAAEQRQAADDEQKEKEKLKMQSKKQHRTKKPTKAPIEIAPAPTTPAIRIRPYPEPGQADEGVEESSAVLVPPNSAIVEVQIGKLRLLDNSPLHHAQFDEGRVFVEWNFLDFERDHCVTEDDVEIPRRPTDSVNFAHQSAYELNPNRIALLSQWTELNIRLTFTLVMMDPGEGNGDLDDLCMGELDLLEVLDSSTHSLLMRNVDNLSVAVLEVGVAYSANLLEYMREAMHGIMDEKDDDEGEDGEMFEQIIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYU3</accession>
    <name>A0A914HYU3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HYU3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g505.t1">
        <property type="protein sequence ID" value="Gr19_v10_g505.t1"/>
        <property type="gene ID" value="Gr19_v10_g505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053352">
        <property type="entry name" value="FMRFamide_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323:SF4">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FRPR-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="10"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g505.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29451" checksum="C278FB825F9590A0" modified="2023-02-22" version="1">MDTLRHILASSSLAMVVFGCFGNCLSAIIFLQRKTSINILLSALAFIDIGLLLFAIPVFILPTLDRWDGFITLESVQAIVVKFLYPVNLMFQTWSIYTIVLITAERWLAICRPLHVRSLCTSRTAKWSLLFTAIFSVLYNIVRFWEYSLSWTPDGSLFFERNLRDPTEHPFYVLWYYSMLFLVTHFLLPFGTIFTLNAVVCHRILRLRSVREQLTMKQRREHSTTTMYKNGLMFSRILWPLYAAAGHCRICPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0I7</accession>
    <name>A0A914I0I7_GLORO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0I7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5485.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5485.t1"/>
        <property type="gene ID" value="Gr19_v10_g5485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5485.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16750" checksum="C8D61B053F700867" modified="2023-02-22" version="1">MAFPMLSELVTLHTKDLSKSVPGTPHTFCALIAALKAECDQFAEIVAGLMSTIHRISIQFTNERKFIAILKVASSFKLERLNPFEDAARKRNSDAVQGEVEIGWDIEKICPQVFVRNVRPRDKLLQADSAPTSTPAFTHCADSICCSASTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1E6</accession>
    <name>A0A914I1E6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1E6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5988.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5988.t1"/>
        <property type="gene ID" value="Gr19_v10_g5988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5988.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8229" checksum="23440B1CD3E61558" modified="2023-02-22" version="1">MSFTLPPTPAPPTTVTTTTKKTTKAPKPTTSTHKTSKGHRLVAEMLLALGLPMLLGILPFFHEKMFAMLYGHHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I246</accession>
    <name>A0A914I246_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I246"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5908.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5908.t1"/>
        <property type="gene ID" value="Gr19_v10_g5908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5908.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28464" checksum="FD3E7E764C5D68A4" modified="2023-02-22" version="1">MSRRYDTRTTIFSPEGRLYQVEYAMEAIGQAGTCLGIRAPDGIFIAAQKLATHKLLDDQIMNEKIYKVAENIYCTVAGITSDANVLIDKLREMAVANTLQYGENISVEQLVVRLCDVKQHYTQIGGKRPFGVSLLYAGWDCHHGFQLYQSDPSGNYGGWRATCIGKGHQNAISMLKQEYKDEEMTLDKAKDLAMKVLSKTMDAKIAVDKLEMAELTLVQGRPVLRMFDETERKRLIEKWEASEAAQQQQREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2D4</accession>
    <name>A0A914I2D4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2D4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6215.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6215.t1"/>
        <property type="gene ID" value="Gr19_v10_g6215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6215.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="22799" checksum="DA4E88E6A062411A" modified="2023-02-22" version="1">MDANCFRPFLYYVDGDQAKQLCAKVGGDMVSFIEEASPEYANLVVDELNVAQELQLSMPGKKNGVLCKKPASNGQNNELFDKICPELATKWPAPTKSEPPNVPVAQLVKKSDRLEEPDFAGQPGQNGQHGQSGQNGGQLASELKSSSSNAFSSGPSASSSASLKAKKSSAASSNIMGKVVHSAQLSASLGGHSNSKAEASHSASYVHEISHSLDHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2P2</accession>
    <name>A0A914I2P2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Triple functional domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I2P2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g631.t1">
        <property type="protein sequence ID" value="Gr19_v10_g631.t1"/>
        <property type="gene ID" value="Gr19_v10_g631"/>
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    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13241">
        <property type="entry name" value="PH2_Kalirin_Trio_p63RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rho guanine nucleotide exchange factor 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="373"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="569"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="706"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g631.t1"/>
        </source>
    </evidence>
    <sequence length="756" mass="82947" checksum="E409AAC3D65A0E6A" modified="2023-02-22" version="1">MLSRRFGRSQTIEEDHNKDVESCSKKEQHQQRKKLSAAAIFNGFNEAANFATRHNPVKKSSFSYIRWPTFSPQQSVKKKSADECCCCSSSPQVPKSAKSFPSKGTSEMEAFGGLPKRFSFAINRKKWFSTSTTVEHNGRATAESSRRTSTSELPSVVLSITNSEKESPSGISSQSPADETHTLATALSAKRTSIRRFFSSNQSTSKSSHHHNHHPQRPPSNPNVTFDQPCTSFDQSSSSSFHSSAVASNSGVDLLPVSPPPPPVLSSVCHPSSSPPSSSTTATTTLPQPLPSSAITRASDPDLPPPMSQLSSAVGTTEAVNGEGLAQQPNSLEMAGESNNACLATDEATSSLTNAASNTPVEAMSSEESARLKRSYVLQELVESERTYVQDLASISDGYIASLREMELSDEDREKVKIIFANIEQILDFHKTFFLKEVEKSLHDHDAAGNAFIKYERRLHTFYVKYCQNKPKSDFLVSQDSFEQLFSDIKEKLGHKVALSDLLIKPVQRITKYQLMLSDILKYTHRSGDNAEVLERAHDIMRVVPKACDDMMQVGRLQGFQGNLTAQGRLIFQGTLFISDGGVFQPFKGKERRVFLFEQSVIIAECIPPRKEYGNPTYNFKNQIMVNKMMLDERVPDEPLRFVLQSSDPNQQATYVAQAASADDKEQWLAKLSAQLDQQKTFLNALVDPKRYQNQLANSIGAISLSGKKDSSGSLGTPTSPAPPSSVGGTSPTKPLSAPHKSSSSKLFGFGGKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3V0</accession>
    <name>A0A914I3V0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Guanine nucleotide-binding protein G(I) subunit alpha</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(i/o/t/z) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3V0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7064.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7064.t1"/>
        <property type="gene ID" value="Gr19_v10_g7064"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002487">
        <property type="entry name" value="Guanine nucleotide-binding protein G(i) subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF227">
        <property type="entry name" value="G PROTEIN ALPHA I SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7064.t1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40977" checksum="1BA2F07900CA64D8" modified="2023-02-22" version="1">MGCINSVSDKNAKARSRQIDEQLKADHDRAQREVKLLLLGAGESGKSTIVKQMKIIHETGYSDEERKAYRPVVYSNTIQSMMAILRAMGRLKINFASPSKREESVQFFQHAQTTEDGELPLELAAAMKHLWADTGVQECFERSREYQLNDSAAYYLNSLDRIAQPGYVPTQDDVLRTRVKTTGIVETHFTYKDLNFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSEYDMVLAEDDEMNRMIESMKLFDSICNNKWFLNTSIILFLNKKDLFEEKIRRSPLTLCFPEYTGSNTYEEAATYIQYQFESLNKRKDGQKEIYTHFTCATDTNNIRFVFDAVTDIIVKENLRLIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5J6</accession>
    <name>A0A914I5J6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g752.t1">
        <property type="protein sequence ID" value="Gr19_v10_g752.t1"/>
        <property type="gene ID" value="Gr19_v10_g752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015212">
        <property type="entry name" value="RGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09128">
        <property type="entry name" value="RGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="101"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="699"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="14">
        <location>
            <begin position="1159"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1384"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="296"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1033"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1738"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1044"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1777"/>
            <end position="1790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g752.t1"/>
        </source>
    </evidence>
    <sequence length="1790" mass="195534" checksum="4A22374FC10B4C09" modified="2023-02-22" version="1">MSRWSIISEESSSNSSATNHKPSIPEFSRQCRRFSPPTSTATAAGDGDAQPIKKAATDGGAAANCLQNILATVDMAPPAVQQLSETLQQQQPQQQKMTERCVLVARQPDGYGLTVNGEYPVKVAAVKHNGAAHLAGVRAGDRILKVNGMPVTAQNFQEVIKMISGGYNLALTLLGPAAMAASSWDDFDKLFPVQHQQTPVVQCPQSPPAAMIITGGDNNNSGQKMEMLNDPNWRQRCANELFRALQRERTNLEANMHRSDKQQQQHIIGPAGGGIKLERALGRISQLERKLNALSPLLNNNNNGRIEHADNNNFNTYQQQQQQTRRRRRGTNAGKCGGGTEKRVSLCSAAESGVSEQQSNKTFPPSSMRVAPPKSAATAAVVAAKVEPIRSWVETGGMHYIHQQQQQQQQTTTPADLLLMGDELEEAQEEEDEGRNSDLGSNDDPVGPFSNLQELKSHPAALAIFLTHLMNTPNPGSLLFYLITDAFPSSSVKDQRRFAYEIFSTFLIPGAPLQLPNIAQRDIQIIDKVLRTICGSQQPPEGTDQLRKLFISTRTRAVSQINEQLADFRRRGQPFEPVDGVDSVLLDSLTSRADRGAELRLAGRLLFKTLQNLAKSSTTAPFAAIPDFENIERRTLALIMSIATLIKVVFCLRTSNSALEKLLDKCPTFLMPTSKHSGAGTSMFKMLASSAKQKFQLKDHQFLLQPVLLTVHCYQCREAVWGVNPQAYFCQNCDVVVHKNCTSQLTDHCWPTQQQKAKTGPQHHHHHYQRQPSASVSTLSLLNTVNAPLHPSSTTRLKHAGGATTAAGVHYKGVGESVSTYAQSLGGHDSVYSVSILNFPKQQRPKRSSPKSSLSLTPPLGRSVHSTALDMKAGSKEGSSIDKHGNDLIPPYEHEMMIDADHHHHPPQHHQQIIGTISPAKMHQPKMESLDSSSSPPSSTAMLPPPVFSTRFERIAPPDVPPSVALDSAATQPATKTHRTPIEAHAKVVQPITSMDSGICTQASSSSAPVVTTASTTTTPAAAAVAASAVPTRSQSIKKAEHVGGSGGGGSSLKRGPGGSLGAADSSGGIAQLAIPTAAALKACSAGDIAQSPHSCLAGTSSSSCVELNAEEEERRLVDLVERFDLDWGSDLEVDTEIPSLESLVSWEILKHLKPKEKKRQEVVNELYQTGYEKDTVLYKVFYRPMVLQRVASPHLVKLLFGNLDELLKLHAEMCQKMKRLRRPNGLYGDLGAPVEELFSGQCGAKFKATVALFCQNQQHALDALRHRYNRAKDDPFSQFLADAENNPLCRKLQLKDMIPVEMQRLVKYPLLLETVAKYTPDPSDELQKLLSGIQGAKNIVSEVNSAKRNADNVRRMEELQKKLDFSAVEKGGFFQKFDFRMHKLIYEGPLVWRQARGKTVDLHVVLLEHLLVFLTKAETGGSGGGGQPNLQLKIHEAGCIPIMRLASVEVEEKVGEKRAFNLLYKCDLRMFELVTQTATERKTWFRLIDNQASVSRLSPVPAELFLDGTLPTVWAHPTGAGRLTPLTTKSSEDGSLQQLSSSSLDQVHVLTHPSLVNANEIVIQQPTVMDNAQPVLSMAERLRKNDRMIFASLAEKHQILAELLNDRAAATAIEDDDDNNREKGGGGISALLDRMADQMTGLAVFDLKQRNAKELAMSAIVQGNRLLECINKGMVVKPSEDPNAKPLLDNEDELMLPSVPCYKLTSVAAPLMNHLKAMLQVLQDQEREIQTLKQRLKETQANPSRKTASEETLVESAPFPVVGHPPQATKAALSPGTPPPPPSSNPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5M2</accession>
    <name>A0A914I5M2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5M2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7732.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7732.t1"/>
        <property type="gene ID" value="Gr19_v10_g7732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="168"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7732.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31874" checksum="8BAFABCB9E4C48C5" modified="2023-02-22" version="1">MTVNVLHVGGLRVRNGKRVGLKEVVFAFNHAAQPADRPESVQAAKRAQERLHKSWIFEKFIGVDFGLKPKYPQFISNRTQPSPLVANLFVSPNSTETTESAEDEAESSLTSKPQLQEIFIVKMPMGVTRHFRPGTYEPDGKNNLLISNNREEDEDEREVVRERLSESPVLVITGLETSWGRALTRFDLIQLFSCYGDVIDCGVFLRRRIPTALDGTPVPPPRPFALVQLNNAEQATRAMNSLDYTWQMGRFIKVTYARERSILVTNSSIKLKYRSKILPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6J6</accession>
    <name>A0A914I6J6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6J6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7367.t3">
        <property type="protein sequence ID" value="Gr19_v10_g7367.t3"/>
        <property type="gene ID" value="Gr19_v10_g7367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037203693" evidence="2">
        <location>
            <begin position="30"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7367.t3"/>
        </source>
    </evidence>
    <sequence length="663" mass="71335" checksum="CA5E87599628416A" modified="2023-02-22" version="1">MNARLSLNVSFLVTICLLLLLLNMNEVHGKKRRHRPVQRAAKISKSAAIDVKNKNCEDEQGGAAKENKLLSPWAWKSDNSLAFDIAITLPPADGNSTRTSSSNTTTQLTTMASSSTTVATEQFLLNDVDGMAQQQPQREAAENGAGNLTALSATERELDNSATIATTTTTKPLQTESWAQNAEEPAELARNRLKPSLKFTGANASAMAPDVGTLPPGIEPSPPAFVSAEELLLNNKLIDDIDMATQSSSTLSNDSLAADIGFTRLPYINNGTEFAEPAPIVPFNSKAREEESLTDLELQPPHLGQADFFTLPDNGSSTEVSAGGDQTAEKAKCQRQRQESANEKAAADYHVQEPYPAHSAESTVPTSPSDTTVLPITAEGILAGDQSNKKLHEAPTPPKHNLISFDAAVDNKTLPGTDQSTVVVDDRKGADKLFNPLNNSIEGNVIKTKEENCCKLLRFLKGKRDNGSEFASAIDGEEGGISELFSGTDLGDQKIIDAVESNNKLGTKGREEAEANEEKLEGATVKAHWEVVQDASTTTGGGGGLEILKEELRERDFNRIQSHADSSEHRTPTAPLNLANSIETATTSSSISSFLPSSTTPPPRPIKKWTPYVFDCALEADERGESLCQEWAKGGLCEINRATRFLFCRKTCLCIGILDSANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6Z6</accession>
    <name>A0A914I6Z6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SURP motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6Z6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7197.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7197.t2"/>
        <property type="gene ID" value="Gr19_v10_g7197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF15">
        <property type="entry name" value="SPLICING FACTOR, SUPPRESSOR OF WHITE-APRICOT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="252"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="494"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="691"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7197.t2"/>
        </source>
    </evidence>
    <sequence length="818" mass="92888" checksum="099A9D32CAAE3C48" modified="2023-02-22" version="1">MATNRPLHQRRKPKHHRHGSVHNGTRSSEQQADDFLVFGYSAKLNSPRNEQQHGSADEQQQPLDESVHLIPWNGDDRLKIDRDGRHVVVLRHALMSTECQHLGECADVSTTSSTSNRSACFFGLFFVRSYDVRLYLSSLNEFDDERRGENRKKLADEKEDENTAEKLEEELCEEERYLDLYEDIREREIEEANQKRGKGAEFDFTYEEREVAQIGAVDECEGVEDEQPFEQPPSLKLPMGIITPETMRQNALIERTAQFVVAQGPQMEVVIKAKQRQNAEQFGFLDFDHGLHPYYKYMCKLIREKKYFPQPQNQRKKRNIVEDPSTSESDSENDDVGYLHPSLLGGVKTKATEDDASSPKPGFIGPSPRPTPQRVERKPASPGPDIGALVQQFHSSSNPNSLYSSLLKGLHSVLPGSPKAENAGKSDADSSPTQTIGHLPSAEPLVSTAFVVDQQRADDYNRWHMEFYGRPSPFLPGPPSACQRPVPDSAVESAITVAAKYVALHGAFAEQRLIEHNRDKVHFLQPTSPYYTFYQLQVRQIQWKFFHQSHQHHQRHQSFPAPPPPPIGLGNAAALMVPSPPPNSLDLMVPMPTQIVIDKTGVAETNEAEPDFKQLERREKARLFMGKILNERMAEKHRTKTKPHEVEENREPVPVIALTSSSTAAVHPTASSTVSPLELSKAISSLIDEQIKRTLGTSPSRSPEGGEGRKRKLKRRDDVEGEGRRQRKKGGRTYPRSSRSSSSAFSSSAEEEDGTERRRKRSKGRERRSRRYESGSESDGAKEERRRRRRKEKDSGSSSHRRRHHRRHRSRSSRSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I722</accession>
    <name>A0A914I722_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I722"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g810.t1">
        <property type="protein sequence ID" value="Gr19_v10_g810.t1"/>
        <property type="gene ID" value="Gr19_v10_g810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g810.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24262" checksum="249484A3A24A817C" modified="2023-02-22" version="1">MSAGGGDDDKFGTGSNIAIALIGDAAAIAWPWPARLSVAGPTFRGRPDFPWPARHSVGGPTFRGRPDIPWPARHSVAGPTFRGRPDIPWPARHSVAGPTFRGRPDIPWPARHSVAGPTFRGRPDIPWPARHSVAGPTFRGRPDIPWPARHSVAGPTFRGRPDIPWPARHSVAGPTFRGRPDFPWPARFDFTWPYFFDKLFEFELEMEVSLGFNDLDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I725</accession>
    <name>A0A914I725_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I725"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7352.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7352.t1"/>
        <property type="gene ID" value="Gr19_v10_g7352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7352.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19067" checksum="E7753B166B3A6423" modified="2023-02-22" version="1">MKNTEQIRKLIASKFVRIFGYVQLPAVILGAFYYVFYDLHKNQKARQQLHTLSPTALKFFYSTEDFISGVGTAFPTTTLAATTPFTRASDLSFKNGVFGKIVERYLDSTEMDPIAMPSWKIFVSKEQEEGRELTLPITNILSDFVMSLLDALVSNTFIRSRPSLFSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I812</accession>
    <name>A0A914I812_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Condensin complex subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I812"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7591.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7591.t1"/>
        <property type="gene ID" value="Gr19_v10_g7591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199:SF4">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7591.t1"/>
        </source>
    </evidence>
    <sequence length="835" mass="95779" checksum="CDC0769D7A233EBE" modified="2023-02-22" version="1">MQQKNVMKDRQQAKLNGGGASNGVDESGFLSGKVGCSEFWEAVKKTVVTNSPDSKICMRWGRTILRAWKNVAKVCPDDRGEARRLAIESEIMEDLFYMAVLTARPFSQRFTWISEAFLEEQKPTKRLKAMLFRCTMPVLWRNLEVPNEDVRFAASALLLKFFPLISDDEFIREEYVVRQQNAMEALLMDDCVPIRVMAVKKLPEHLSAHWEMFPRELIKLLLEKLVDQLSLDSVSEVRAAVYEGFEHLLPCPAALNSTQRSLEILAKRGANDRAERVRLAAFKMLNKLNGHRYIKLTDLISLSDCFLRLDYEPSAHIQAQIVRCLFFPLCSRMVKGIDLLERFKRIYFMCKHSRLASLHFHRLVYSLGLMPINEAVQHIRSLVIGVRKALRQCRGVEHGADDTTDGTLMNITGASTFLADQLDGETEEKMLILKHVLDSAIILWVIIHPDMFNTQYAMENGELTRLMVGVLQELDNFSNTPLMDSALTIASNLPKDKIGRLFGRIRAKLETEQTDHVYFSHFVEAFAAWDMNKLISIIEQALRRLRNAVVAVCDPDCSTPRRRRVTNSNESLPSSVLKGRATESPRAKRARFGEGLVDLRRPLELIQMLLASPQTCTCLKNNFGIHLEGFFELLCVIRYKFGELLVTNGWEAKFDARTLMSAYETFNIVALITKKIEQPRRNSQGEEIGVNEAERDLSLTDRILYNELKWFAIVLHQRTPSFPIIQMFLRCVSLHLCASQLSVMVLNETANMLNELRHRLDTLYDARPMILALRKCVNHLEEALEGCEERDEVERIMEQKTRPMKEYFEAEERGDTTDPAEAENEDYQEIDDGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8S8</accession>
    <name>A0A914I8S8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8S8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8549.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8549.t1"/>
        <property type="gene ID" value="Gr19_v10_g8549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF15">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="317"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="364"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="683"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8549.t1"/>
        </source>
    </evidence>
    <sequence length="787" mass="87643" checksum="3C27D56B6000CA9E" modified="2023-02-22" version="1">MTKGPIVIAGGGLVGLSVAYNLAKRGARDVFLFERHCIGAHHSTRVSTGMINNPNFFADRSLQSIVRKSHELYAELDEHGTLGFTRCGRVYLASKPANSAAELIDCPSEMLSRWPMLATEDVKLALFSPLDAIVDVQSLCRLLTDRCRELGVHIHENVGVKRVLLNERRTTYAVDTDEGFIETGAFVNAAGIWANLVEVPELPDHQALAPPTQTKGAPEWHIPAPSWDHFATILRHLINRFPSMAQLSRGSLITGAEMYTPDIRPLIGESDQACGYFIINGMNGQGLSFAGGLGAVLAEWVLEGRAPSKTSAVVDKLDVTRFLPLHANPQYLFQRVPEVASNIFKNLSSSHQCHTARNLRTSPIHHHLRAAGAVFAETMGYERPLWYEVPAHSSGTTTVGSSDSHELRPHRQALFTAQDPLVGRPTWFPMVAKEYEACRESVGIVDMTSFAKFDISGPDVVPLLQKLCSANIDRPVGTTVYTGMHNEKGGYVSDATVSRMSNDSYFMVAPTIQQVRLALWVQRWVNEWAMDVRLQDVTNNFIALDIVGPASRDLMRALTNESVTPHDFPSFAFRTVHLGLVGPLRAISVSHCGELGWMLYIPNELVLNAYEQLVDAGTEHSLRHCGYYALRHLRIEKFYVYWGQDIDSMTTPVECGRVFRVDFEKDFIGKDALNRQLERGVSKRFVQLLVDEHDMDRDPWPHGDEPIFRDGALAGWTTTAAYGFTLGCQVCLGFVQNDQFGVSSEYLTRGTYEVELAGKRFPCRINLHSPSLPMISSEHPNHYRPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAX6</accession>
    <name>A0A914IAX6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mediator complex subunit Med12 LCEWAV-domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8907.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8907.t2"/>
        <property type="gene ID" value="Gr19_v10_g8907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021990">
        <property type="entry name" value="Mediator_Med12_LCEWAV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF42">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_90, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12145">
        <property type="entry name" value="Med12-LCEWAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12 LCEWAV-domain" evidence="9">
        <location>
            <begin position="389"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="684"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1962"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2157"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1967"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2055"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2157"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2192"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2233"/>
            <end position="2252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8907.t2"/>
        </source>
    </evidence>
    <sequence length="2252" mass="256534" checksum="06D22C5D44EE5534" modified="2023-02-22" version="1">MPRANKLTKQEQVAVCCDGDQLDNHIQRIQTRGHLSPDARPLKRSPKSHRQSGGEKGGSSVPITLHADVYPQQEKQEEDNLGPERLARGYQIEVIHRSLVAHEYDTIMKTSNVRFFTNNEQFSKAATLIKQIVQKKNEMNTVFLDKNWLKDNMLRSFKEGIRSEFFESLATGRRLQIKDKRLSLNSSFPKFIRVTIDRLTSLSPQKVSFPLCEAMDLLFEKGVPVQRAIWFFKMNQIAHLLTFPNKPKKGTLVMPCEDYASDQRQFFVRYLRCVLKEFDKAIPGQLEQNIYYQKWPYTVTLIKHSFEDGMLDRHEFVNDLCDLLPEFANFSMEQPQTFRALLILISQFVDVITQNIFIARKVAHVLCVRLNQYRRDYELIRGASTLEVPAGECFEDLTNCHHHRPTLLTMFGMIHAILIDCPSALPDKSGNSSKLIERESAQNNVAWLCKSPLDQLPCELSVTTQHLAAHAKAQVDQILNIRIEEIKQRSQAIEDRWVHISPSNTRSGLDSIVESCLDILSFLDTVDLGAVDALLVLYNNIFGEDNDCLDITIRVLIYWAVTVEREGSHRGLIIAHLLRMHVHFAQKDGKKLPFGDGFPFLQDLLVDCLNKDWAQPTGKAATNLAFWTAEFANLMLLFYELQRFGLFNHDKYVKALMRDGTLDSRGLFSRLNLNALSVTSGNKSASLSADERANRKPNSLATVQGLPPAQSQPETNVKQEHQMIISFIPMSKPTPPSLNTSVEQQSNNNLSSVQHGGTSQTPKQMEEFAKLPPQFETDNHPFLNESSELSFAERFIVHLPVEQIESNRDVCNQRAIVLYGISEQRDNARQELRKIAREICKAWKKKTFELTTAPHCQPNSVQPEVRYKRRCTPEQLSELMGRFNVQTYYDQLVICGWCAESFLDSVEEFVRQAGELAQEGGAGGTQIVNVSVPAQECLDMLCTMMTICRSINSIITLAQELMPLLIHLRWILKNQLHVDHFSASVSAQYAFVLVSHLAEHFFYLLYSPEACSIINDLYRLVENELGAPIRRKENGEGTGWSRAVAIFVYHARHHLLVSKLNVRGSGPDDIVQLLGRCEEFEAVFPPSGGGSVAANLEYHQQLTDDPSRMSFNDLRNFFNQSYKRLAHSMRNDSVRYSFVIDAFKTAVSCDRNYDRLIELANFCANISANWNLTTEWCNAIQELCYPSASSGDWKELIQDIDATKFSTHYAIATFTLLLASKYCFSTHGLICRLIANVLSPLLSKQEERNENMTMAHRKTDDFGGHDNNFCLTLYICACLCCGTDEPFQYCENNSKSSATSVSVFSRDANKMALRIVHLVELETSIFPLLCVVVQLVDGLKRKVEARKDAVHFRIAQNYLVARCALLSICEQEWVIQRMFCLCDSHDELEMFTNSDRLRNHYVGQQLLRWSLRRKSERSIKQELIEHTGDKKVYERLLSTLSVWNMRATYYDFKLNILEQNPDNQPAKTSNGNQQLASSYQMVMYQQALFNNVANACHLLFKEHLLKGNHCEDLTTVQNFCLTAINCHWLIAPLVNALPSPSPPTTGNPQNTLWCPWNSSAMKAYLLKVVADNLSSTNTERTVQYEQLLGYQPFLNLVLSCTEGEEIKQLLDSLLFYIDDIVKRVKKNAVVPYQNSFFPERDGLILRLNLISGLFDSLLANNNVDLWASAFFQMLYYEIVTDERDRDYFDTCYDMLLMLCFRIYPHKMYTNFIAKFKNLRIPDELYCLQQLLPVAKSQSELSAWGSFKNLINKPIPMAGKGSGGGSTAHFSQQSPITVPNKPKISGIIVDKQTISLQKQMLRVLRHQHWLQKHHSSPKGDLLVSFIPRPGVVGESDISGRNNANLFLAAPEMEQVAALALEEVPSDVLQRQQIQIMQQHQQQQQVVRQQQQQQNTLMVEQQQQQNHHQQMFTQQQQQQIQQPNLMTQMNVVQPPQQQQFSQHQQQMFQPQQQHLVPLHGMLAEGLPGMTTSQQASVRSGSSTPATDSPKTGAGRGGRRKNAAAVSGTNQMQSTGAVVATTGAGRGQKRKKEPKQPQLQQQQSNLGGTEMFRGGQQSGSMIPSQMGGQSSMNQAAMIMQQQQQQQQQMTAQFQQQQQWQQQMQRQQQPMMGNAMMFSAQQQPMPAQAVLPLPTTAAQFRPQQMQTSQQHLQQLHQFPPLHQQQQHQQMRPNHQPQPQFPHPQMMQGMPQPPPAQQQQQQIPQMQHHSQIGGGDQQQQKSNSSNRSVIQQRLMLRVQSQQNQVQQQQHMGMPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB08</accession>
    <name>A0A914IB08_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FACT complex subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB08"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8929.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8929.t1"/>
        <property type="gene ID" value="Gr19_v10_g8929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8929.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11522" checksum="82647A830E3DABD8" modified="2023-02-22" version="1">MDRPTPFHIIIIQPQNEEQMQFAKSAFTKSTLWGATVFGGPDNAQFNSEQSPLKGVAANEHISAKGGPGNAIRTALAEQTERRTTDAKNQNKVTRETINSRRLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB60</accession>
    <name>A0A914IB60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8270.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8270.t1"/>
        <property type="gene ID" value="Gr19_v10_g8270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036998606" evidence="1">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8270.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17166" checksum="C7E56FF6044E83B3" modified="2023-02-22" version="1">MAFAHPFFVFFFVAFCLYITPSGAILCRTGVDQIRGPVADCGSSNQCLNTSSPRATVYSCDHAGICETILNMRDGCVKDGQNMVCCCSTADGCNYGLREVVVVESVPAPDEKLNGPGASGNALGKILLPLTAKSMGGELIVDSTNLHQSTGFPSSTLLPFCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB98</accession>
    <name>A0A914IB98_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tropomodulin</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IB98"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8353.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8353.t1"/>
        <property type="gene ID" value="Gr19_v10_g8353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000099">
        <property type="entry name" value="Tropomodulin, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8353.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25029" checksum="7184E4E401596DDE" modified="2023-02-22" version="1">MHNVLNQPQYYNALKGKGQNEETGISFSGVIKAFQPRVVPDEPENVTDVEECTRRLESDDMALEEININNMKRVSKERIRTMIRAACKSKHLKKLHMANTAISDQEARPLVELIEQSGTLKVLNVESNFISPEMVAKLLRATLQTQSLVELHAENQRQTVLGNQIEMDIMLSVEDNDSLLRVGVSLQSMEARNRVGEALERNYERLRLKRLENKSTDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC24</accession>
    <name>A0A914IC24_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IC24"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9223.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9223.t1"/>
        <property type="gene ID" value="Gr19_v10_g9223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037297773" evidence="3">
        <location>
            <begin position="29"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9223.t1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46466" checksum="BF55A39BD01C9290" modified="2023-02-22" version="1">MTTKKILTIKFFSTILLVYQPSTYTVLATSGEKIPQIFQEDPAGGNNDNEIEDDIEKAQMFRSKTIRDLTNEEISELVGMLRKSDFLRFNMKANESKEVGTHINKVKKQLLRIPNIKAQRIVPQPIDDDQDTSNDEQSPEHIMQGPPFDRSPQPQSSDDEAEAMLFFGKDHAKWRRWKANKIGLANIIGTLRISIDRWANEVKTNKQIKIATKNEWDTIRQNRIEKLVVTLLNSREASTSETPQNGDNGKKLVRGGPYINAALYSPEVIEQLEKQGKKILLTKKYDLVAHAKAIAEAKQNLAKYDKQMLDLAKLEAQFDALSFTKSAKASTKKQRKAKGNQKQQIAQKMIRQIQAINGVLNCLYVNVAEMVESGFTEEKKKLSKTFIYTLRKMQSDDNGEEEQTDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID00</accession>
    <name>A0A914ID00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9069.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9069.t1"/>
        <property type="gene ID" value="Gr19_v10_g9069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9069.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12283" checksum="81BB6D337D597FC0" modified="2023-02-22" version="1">MGSGQLDSGQSDSEDNPTEVDNRTVDNPTPRGLAQTLNSHYKFRSPSTTLCQSFCQNNGGEDRHLEFGMERKKNVEKVAAIRAIYRNRANRPFLAYLKGLLTDYQNDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID10</accession>
    <name>A0A914ID10_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GH18 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID10"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9712.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9712.t1"/>
        <property type="gene ID" value="Gr19_v10_g9712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073:SF9">
        <property type="entry name" value="GH18 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036951368" evidence="1">
        <location>
            <begin position="25"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="24"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9712.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="37651" checksum="524614342661AE8C" modified="2023-02-22" version="1">MNKFLGILFCAWIHQLAIVSVSSGRVVGYYQGNRALTSAQAKKLTHLILAFSVPDAQGNLSPLTSVQAQALTTGKSANSALKVLIAIGGGGFNASTFTSLTSNNGTRQEFIAKIVSFLKSNGLDGANIDWQFPTVNDKANYVAFLHELNMALPSGALLSIASAASAFYLDPGFDLAGIATAVDFINVMCYNYYGGWSTESTGPNSALYQGANAGPSDSLNTNWTIVYHLTKISDPEKLNLGVPFYGKYWNNVGAPLNGDGLWRQLGIYGTELAWRDLGNSSDLTKMTYHKTAKTPYIYDASSKIFLTFDNPQSLEDKVQYVASQKIGGTMIWAIDQDDDKLSLLNAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID17</accession>
    <name>A0A914ID17_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ID17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9475.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9475.t1"/>
        <property type="gene ID" value="Gr19_v10_g9475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF98">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036803635" description="Sodium/hydrogen exchanger" evidence="11">
        <location>
            <begin position="24"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="78"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9475.t1"/>
        </source>
    </evidence>
    <sequence length="766" mass="87305" checksum="8B7A1E04E31F2F93" modified="2023-02-22" version="1">MAKFYALFAIFLCIVLFTKFSDQFPTTKHDDRRTLISYSAIQSKYNDTGQIPKRHFQLLIFDWDEVSTPYYISAWLLLASTSKILFHVNKRMAEALPDSALLIVLGFVLGFILRLCQIDHRIYMFQSPTFFLYLLPPIIFDAGFFMPNRQLFDNFDSILLFAFVGTIWNTIAIGYSLNWMGQAGFFSVPFSSFQILLFASLISSVDPVAVIGIFEEINVNEFLFINVFGEALFNDGAAVTLYKMFQEFAVIGPYNLEAMDYFEGFLSFFVISIGGIILGLFFAAITCIATKYTEMRLITPIFVFVVPYMSYLTAEMLGISSILAIIACAIGMKQYVKGNLSHDAYSSVKYFTKMLAQCSETVIFLFLGFSTVSREYKWDWTFVCSTIAFCLIHRTVGVAVQCAVLNAFRHKKFSFTDQFVLSYGGLRGAIAFGLVMSMHQSADQFPARSMFISTTLAVIFFTVFVQGISIRPLLFWLKVKKSDFAGVETMMSNKIFQRYTDHTMSGLEAILGHRGSNSLRDTFERFNDNVLTPLLMRAEQRKTYDASPIMRAYRKITLHEALQLTQSGSKISKKTARIGRYRSQTESLPPATILHSVSRVGEQKMIDIDQFLSNRENVELLYLMFSRMLDRKIEEMQKARLDAGWEDDVKDDYMGIIGAQIQQVENGSICTQRLRKPTKFLLRRESSLPNRTTRLMMNGTMVDGTKDATLAARNGIEPTNRSRPQRKLSLPLPTRHLQWRVARQESERVNAWETNGPKIDGNKSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDT2</accession>
    <name>A0A914IDT2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDT2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9296.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9296.t1"/>
        <property type="gene ID" value="Gr19_v10_g9296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9296.t1"/>
        </source>
    </evidence>
    <sequence length="1063" mass="116629" checksum="63A912BB745B5FE7" modified="2023-02-22" version="1">MHIVYYRDYGDYHIKEMIHRNIENGKNFEINVLEAEQTEKFTLGFAFNIYPLADEFVLINNAEDDEDPHDDGPYHQAESELNAFDIRTLFKIVRIDMYRPNFTKRHLINLGSADPCALFWNRQVIFEANKDTGNYHAFLYASVNKNQRYHESKDTKTFLGYSPLLKIDGRRGGANKDVPQFSEYQVTIPVKLENLFKHKLWNLKMHIYQFDEDDLPAGNNHNQISDDVDTCPICLESLTTLENRPILKLHGKRSNNSNYEHIYHNDCITTWIVSKETLRCPLCTNEPKLIIVADFTPILFNSALIYHKMYVNPLAQLFQIANSDEPDTFKHSQVLHAFANIVQKIQKAESAIKKCLSELDVPLLMDKLFGETFFDIGFRGFVEKQILENVRQELETIVEHNFTHKTMHKAKEILKVIKSIREELESQANAALETIQFIRHREVGHREVWVPGSWAAGTLGTGKFGNREVWAPGSLGTGKLGTGKFGYREVGHREVWAPGSLGTGKLGTGKFGHREVWAPGSLGTGKLGTGKFGYREVGHREVWAPGSLGTGKFGHREVWAPGSWAPGSLGTGKLGTGKFGHREVWAPGSLGTGKLGTGSLGTGKLGTGKFGHRGIWAPGSWAPGSLGTGSWAPGSLGPEVGHRIVWGTGKLGNREVWAPEVWAPGSWAPGSLGTGKFGHREVWAPGSLGTGKFGHREVGHRKFGHREVWAPGSLGTGKFGHREVWAPGSLGTGKFGHREVWAPGSLGTGSLGTGKFGHREVWAPGSLGTGKLGTGKFGAPGSLGTGKFGHREVWAPGSLGTGKLGTGKFGHREVWAPGSLGTGKFGHREVWAPGSLGTGSLGTGKFGHREVWAPGSLGTGKFGHREVWAPGSLGTGKFGHRELGHREVWAPGSLGTGKFGTGKFGHREVWAPGSLGTGKFGHREVGHREVWHREVGHREVWAPGSWAPGKFGHREVWAPGSLGTGKFGHREVWAPGSLGTGKFGHREVWHREVWAPGSLGTGKFGHREVWAPGSLGTGKFGYREVWAPGSLGTGKFGHREVWAPGSLGSGKFGHREVWAHREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDT6</accession>
    <name>A0A914IDT6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDT6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9927.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9927.t1"/>
        <property type="gene ID" value="Gr19_v10_g9927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF93">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="205"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9927.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34022" checksum="ECCC62B32E1D49CE" modified="2023-02-22" version="1">MVFLIQALYRLIRSPRVKQVKPFTLHCSLLLVVFGYALIGGLIFNRLEAGATEEQQRLEWRRKSACVMQALERGPLPLEESYWAVNNTAEQILQCFKTEPDARSQWGLMTATLYGFGIVTTLGYNRIAPITLSGRLFCVFFGICGIPLTMIIIANIGQYLNQFAGATRKNIEAYRERRRRSRVSISGEDIGDSSIEVMSIGLLVAFLLYVCFGAVLLPLLNGTFDFYNGIYYNFLCLTAIDFGQLVPSRWAFLPITFLYVCIGLAITTIAIDIGSEYMKKLHHFGKKMKNVASTKIWFGGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDU5</accession>
    <name>A0A914IDU5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDU5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8977.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8977.t2"/>
        <property type="gene ID" value="Gr19_v10_g8977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8977.t2"/>
        </source>
    </evidence>
    <sequence length="151" mass="16494" checksum="C8870AF6A5848F84" modified="2023-02-22" version="1">MMMTTDRTRARARANGGSDDDDDDDYQTAENDNKCPDQQQARLVELLEQIAKTAQKPSIVRSENYPAFFLAMLIKTLLTVLLLLAVHVGLSTVEARWGYPGGGWGGYPRWGGGGWGGGYPRWGGGGWGGGYPRWGGGGWGGYPRWGGRRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE63</accession>
    <name>A0A914IE63_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE63"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g907.t1">
        <property type="protein sequence ID" value="Gr19_v10_g907.t1"/>
        <property type="gene ID" value="Gr19_v10_g907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g907.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16757" checksum="8B85FE2D2A08F255" modified="2023-02-22" version="1">MEGRKKGKKEQMNERKGRQERRKEWKEERKGGRKRGMEVVNGRHGREKEMNGREGRKKGGGNTGKEKKMNGKEDRKGGRNGRKRGMEVVNGRHGREKEMNGKEDRKRRMEGRKKGKKEQMNERRGRQERRKEWKEERNGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IED5</accession>
    <name>A0A914IED5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IED5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9446.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9446.t1"/>
        <property type="gene ID" value="Gr19_v10_g9446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF326">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER SNF-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9446.t1"/>
        </source>
    </evidence>
    <sequence length="653" mass="73478" checksum="90B64D568E2F8F07" modified="2023-02-22" version="1">MKRTTFLGMQWHFCSHCPSWSQRVSNWIAQLFVTLLSNRACIGYAVGLSNIWRFPSLAYENGGGAFLVPYLTCSLLIGFPLLYLEMSLGQFCKAGPAVVYGWIRPAFQGVGWSMAMVSLLVGIYYNVIVAWSLIYIFIILTGRYSEIASCNSTYNTIYCASSLENARCARELNATGAFFFNKTCHFVTDRLAIALKNETFNALPAVSPAEEFFENYVLEKTQTMDSFGGLNMKMVIALGLAWLITVLVLIRGVEVMGKIAWLTGTTPYIIIVILFIRAVTLDGADIGLDYYLLKPDVSAIFKAKTWRTAATQVCYSLAVGMGGLLSLSSFNSFHNDCFKDAFIITAADAISSIFGGTAVFSTLGFMAKQLNVSIDAVVQSGTGLAFIAYPEAMSRMPGWPWLWQLLFFLMIFILGVASHFGLAEVMCTALYDQFPAFRQYKSWLVIGVCLSCYLAGLSICSRAGIFYFNIFDDYAASFSMMLLVFLELILVAHIYGWHNYRKDIQAMMGQPRNLLSKFYGPSGLCIKYIYCYIAPVLLLIVFLFAFVQQVFTTRVTYGRDKRLYVFPVWSIVFGWFLSLISWIFLPGLLLANMIKFMRQGKPLNEMLKLQPKWPSYERVNKTVKKSKVSNKIDTGSRMRTNSITMREFVHGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEG1</accession>
    <name>A0A914IEG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9865.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9865.t1"/>
        <property type="gene ID" value="Gr19_v10_g9865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9865.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11642" checksum="85B86C59C26FFD55" modified="2023-02-22" version="1">MHFLGAETSLGPKGRGRKSGAETSGPKRRDRKVGAERLYGKKKLYSRAKRADRVWPIASGQSRLAIRVLGPVASGQASPSTKKTRLALRREWRDATGETRLARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IET6</accession>
    <name>A0A914IET6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914IET6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g957.t1">
        <property type="protein sequence ID" value="Gr19_v10_g957.t1"/>
        <property type="gene ID" value="Gr19_v10_g957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000192">
        <property type="entry name" value="CTD small phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040078">
        <property type="entry name" value="RNA_Pol_CTD_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01124">
        <property type="entry name" value="C0.1:_RNA_Pol_CTD_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="244"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="9">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g957.t1"/>
        </source>
    </evidence>
    <sequence length="504" mass="55176" checksum="A96FBFF7EB9EA36C" modified="2023-02-22" version="1">MWTLAGRWDTAAGLVQDEQQKQQQQQQQQQRQRHNHQLAASTAKTATSTAAAQQQTPAVATAAPASTKSKLEKRQSAGGGGRRGGTRAMPKFLHALCCCLRPKAYNKKYDSSSGVDYPDVRGGGGAAVGSSSSSPITQVAVGGGGGKQFQQQSSAAASRAAASNTTKILMGGSEIRHRLSSRQQQQQQQEQRRQQQQQSAGNNNNNNNIKNNSLTLVVGDPQKQQRQSFLNSSSFLLPRVTAGTEANRNCLIVDLDETLVHSSFKPVKNADFIIPVEIDNVVHQVYVLKRPHTDHFLERINALFECVLFTASLAKYADPVVDLLDKRRVFRSRLFRESCVFYEGNYVKDLSRLGRDLRRVIIIDNSPASYAFHPDNSIPVRSWFDDPNDQELLDLLPLLEELAHVDDIYKATGTVPPSQQPRCLTPSEDMLLPPPMEPSSPITQVLPPQQQQKQTSAWIGNNNNNNNNTLPTTTMATTIGGTTITTTAAAAAAVDVGKKSALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF67</accession>
    <name>A0A914IF67_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IF67"/>
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            <begin position="319"/>
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            <dbReference type="Proteomes" id="UP000887572"/>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9349.t2"/>
        </source>
    </evidence>
    <sequence length="456" mass="51839" checksum="390B8DC1B6BBB165" modified="2023-02-22" version="1">MDERSAACHNFIVISAQQNKKLSIFVEVLVRVVVVMDVDECGNFLCCQVHPSLFAVQIGTFWRFISSAGNLALVCRSNWHILAFHLIGGQSGISLPFKLAHFGVLSHRREQSNDDSLCRISESSVLYEKFCAVLDDAHRVRNGKEWLKLRENNKQPPTEDKNGAFAEWSYRYYSIERFFDYCYFLKKSKVCEFSIELVQKKRPFVCKCKKICAPYENTKFQHIALKPEFKYERGDPMSIGDAMRKIVEAYQKLYPGNLQKLQSLISRQKELPKMDFCNKEDCIKVHAWVYYAKNGGDSDVATPKLEQIQKHLLKNVPLNLKEFPPQPPQNEKQTAEKPKIKLPQNYSTSSSSSPRGHYQPNKTVLVTLEHPFQVQATTVVVLEVAMVEVVMGSIVILVVWIVLPVRGRTSSFAASCVRASGVGINANCSLSASVMFSTLRWQVYQPEHLAPSLPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQV3</accession>
    <name>A0A914GQV3_GLORO</name>
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        <submittedName>
            <fullName evidence="3">GPI ethanolamine phosphate transferase 3</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
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            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQV3"/>
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        <property type="gene ID" value="Gr19_v10_g10472"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
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        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
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    </dbReference>
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        <location>
            <begin position="305"/>
            <end position="326"/>
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            <begin position="338"/>
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            <begin position="492"/>
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        <location>
            <begin position="529"/>
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        <location>
            <begin position="598"/>
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    </feature>
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        <location>
            <begin position="628"/>
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            <begin position="658"/>
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    </feature>
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            <begin position="692"/>
            <end position="711"/>
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            <begin position="726"/>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10472.t3"/>
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    </evidence>
    <sequence length="753" mass="85154" checksum="73811B3F7084DA5E" modified="2023-02-22" version="1">MLVDELVLGSAPLDLGFQVTDIARGLLVKRHVLSHRSSCGDVDANDPQCWTSAHFNKTILLIIDALRFDFVFPAHNGIERMDSPSKYYIGQMPLVAELLKSSNAGLFALVTGAEVVEDNIVDQFISRSRNVTLLGDDTWLQLLPGRFNRHFEGPSFDIKDLDTVDNIVIAHIYDELNRTDWSLMIAHCLGVDHAGHRYGPMHPEMSRKLGQMDELVRNVTEEMPDDAVLVVCSCPAEVSSALFVYSNRLNVMANLSNILTVHQVDLVPTLALLLDVPIPFSSIGLMIDTISFTNRNCKNNFAKSFVNMKTLLTILIRISIFLFLLLDNAEEWITMRLWVFRSALLFLQLSLVFADDPTTDMVIFSLTSLGVSLFSQTMVISYKLFGFFADKNPPFSRSLCLTLFVSLVLSLLPMSNSYIIYESDVLRFFLQSVVCVLMLRKLNEKRPLRYQEIPEELKYAFGFLFITRFLKDFEGCREEQVGCFSDNFEKGTMFLLSVMFALGVIWILLEEHSGRVHILTRAFVWSMAVLLILHWAFELSVVGTVPGIVEYGLSAEVSNLHMNKRFVESVSRRLAQIVYIAFFAHLSIFRWLKDPVTSALAGYPYGLQMALTLILFSMSDPLTSMESVWTSVILLHFIGSIPWHAAFIGLPGNFPFKLLPALLVLCNMFSGKVLASLLVFKREKDNTVEGPFCMLLFVGLRVFGSSMAAFIHHQHLMFFKVFAPKFVFEAVDSIFCCTLILLWKILRVDGTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRP9</accession>
    <name>A0A914GRP9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="Gr19_v10_g1056"/>
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            <begin position="12"/>
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            <end position="2232"/>
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    </feature>
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        </source>
    </evidence>
    <sequence length="2258" mass="250083" checksum="B1CBB3502A7C79DD" modified="2023-02-22" version="1">MARIHVGYKWIFFDVLIVVTYCWWFSAVVVAQQQTQQLYQQPFTGYLGGEFEPNAWNSQYIQPVGNRQRSQTNAAIQQQNAAGNGQQQLRGFGSELKDVAQVANNNLKRVASRTGSKIKNAFSTHDDGGPNKTPFGTDSWQTSRVQTASNPSDPWKRVGSTQETPIKGHLKREGEPGSTTDQVGVQRKNEFSLNSMKVEDRSNFDQIGPIETVEDPKDNIENGTNSDQKKSKSTDGPSSEDAMSKKPSLNAASIDQKELKTEKSDVTDPPKALTNDSNRHDFIANKPQKVEDEAPKLIEEESTESNGPSKGQPTKKGSFDASESLKRANIGSKVSDGSSTDSKMEADTLRMAKPGPLGLGTSSTDDSKAANNAPIDSDGPKKEEQNFEHVKYSAKNEPPNSKDSDAEAEHIATNSNSASTVKQNAVESETNPKRVELKGTDETYVEAPLKERANDSVSDKERPNDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSVSDKERANDSVSDKERANDSNDLVSDKERANDSNDLVSDKERANDSVSDKERANDSNDLVSDKERANDSNDSVADKERPNDSNDSVSDKERANDSVLDKERANDSNDSVSDKERPNDSNDSVSDKERANDSNDSVSDKERPNDSKDSVSDKERANDSVSDKERANDSNDSVSDKERANDSNDSVSDKERPNDSNDSVSDKERANDSNDSVSDKERPNDSKDSVSDKERANDSVSDKERANDSNGSVSDKERPNDSKDSVSDKERANDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSNDSVSGKERANDSVSDKERANDSNDLVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSVSDKERANDSNDSVSDKERANDSVPDKERANDSVLDKERANDSKDEDGSNQDKNGLKGFEASSKELDELKTDPTDGLKPNNVKKVTKDFSKNQSDSVDVEGEPKLKHKAGSKSHSRDSSTDQMDAKDGSEDRPDQDEAKDSVIDHKNVENRSKPDQDEAKDSVIDHKNVENRSKPDQDKAKDSVIDHKNVENRSKPDQDEATDSVIDHKNVENRSKPDQDEAKDSVIDHKNVENRSKPDQDEAKDSVIDHKNVENRSKPDQDEAKDSVIDHKNVENRSKPDQDEAKDSVIDHKNVENRSKPDQDEAKDSVIDHKNVEDSIKLDTAKVKKQKTAGDTDQKDLNLNTEKDSESNSNENSSKDKKNAAVNGQKQSNNNFSWQSDQSSGSSSSGSGSRSSSSSSGNESGSSSAGRSNSVNDDNGKELILSKIAEASAPSKNSNSAGRGSQAVSESVAAAAPGGTHEVRHGQIKDQSTREREASKPFKDKHEHLKNFGNEVKDVARSAGHNMKGAASKAGSLLKRTFSKNDRSDGQQIPQGESETFDDKRTLSQSERTDEQQVPQGVSGTAGDGRSISKSDSQGVSGSEHDRTLSKSDREDDRILSSDREDERTRSKSNREDDRTLSKSDREDERTPSKKDREDDRTLSKSDRMDVHQVPQGVSGTAEDERILSKSVQPDEKKGWKSVKDGSVREATRIGSNAAKIARGASRKASNLYHNVKDSDRTASLKQKVANNANRVGSKMGQLSRSASRRASSLFHNVKDSDRTASLKRKVANNANRVGSKMGQLSRSASRRASSVDLHENESKSGGLKKGAQSAWNKAKRGYSRANGYLREKARRHSANNETPRPHSTGANDKKKEEIDTHSFWKHFWATHPIQKIQDQNLVVDNERNNYSNIKSDDGSIEKENSKSNSSEEYEKKLEKSRQKSEQKITEKPKNNRQQFVSDENDDETSESDEETKKRRPGRKLGFNPGKSEEDDDDDEEDDSSEQIDEMPKIAKKSEWKITKRDELSDEDDDEQINDQMEEESLAQKEILAQKLEPKSKEDKKNDEKEADRNSKTDKQSVQISDKNRQDDKNKLEAAKKDGQNIKDKGQNDKNNGQIAKNKEPDDKKDGQKVKSANANVNSKVREEIKKKAQPKQKSSATNETPNRRNPPKTKKLRTPKRPRQRQSPSPVRRRPHHYHPRIVYASYSDYPVYRGAYVDDVAFNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS07</accession>
    <name>A0A914GS07_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS07"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1065.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1065.t1"/>
        <property type="gene ID" value="Gr19_v10_g1065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037691631" evidence="1">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1065.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="26438" checksum="7C705D53683C34A9" modified="2023-02-22" version="1">MTAFQLYILLIAQFFAIYGIDSLSDAEKKESIKDLGAALEIQYNGSYLKKVKSFTELDPAFQELCIQWHDAFDKIKELLYIWQILRFAILEKKELEKDFTNANELKNFIEYKPEDQIIELETDPSHLLTFRPKFFQKMEKGGQILTISEAMKAIQMASRAFFISEKAQECPTFIEFDGQWQKQVDSWEEWHKQNIKKMPRMAKADMVIHHALTNARKRVSKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSR5</accession>
    <name>A0A914GSR5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSR5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10046.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10046.t1"/>
        <property type="gene ID" value="Gr19_v10_g10046"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g10047.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10047.t1"/>
        <property type="gene ID" value="Gr19_v10_g10047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10046.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10047.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13508" checksum="9F5998E98AE07240" modified="2023-02-22" version="1">MFPATVLLAREGSIGRMCRSGINWTNVPFRDQLDECAVQGSIGRMCRSGINWTNVPFTLPPDRKLATLSVDDIILWRSGSICLIAVKVSFAAAAADQQQNCRPRRSSANERRPFKSAIRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSX6</accession>
    <name>A0A914GSX6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSX6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10919.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10919.t1"/>
        <property type="gene ID" value="Gr19_v10_g10919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="82"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10919.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20785" checksum="1B33DA4AE4AA14A9" modified="2023-02-22" version="1">MAAIDLSQEVRLYDNNAERDRIDNMAELYAMVNALECLEKVFSRDYIHAKEYTAECSKLLVQIKVALRLVSGVTIEEFARTYHIQCPAALERIREDRPITLKLNIRAVDELFPNLNDLYASINAMSTLPDDFDAKLKVKAWHDKLHGMAAHEEISDEVARQMIFELETAYNAFQRFLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT34</accession>
    <name>A0A914GT34_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBCD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g10497.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10497.t2"/>
        <property type="gene ID" value="Gr19_v10_g10497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000001">
        <property type="entry name" value="Furin 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF23">
        <property type="entry name" value="FURIN-LIKE PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15 16" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15 16" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="503"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1330"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14 15">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14 15">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14 15">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10497.t2"/>
        </source>
    </evidence>
    <sequence length="2183" mass="241218" checksum="06C4EECAA4B740C2" modified="2023-02-22" version="1">MQNLPETFRSLFLFIVTSVPSARPHPALTDKVPTSPPNPFPKNRMWRWQCNARSGSGRELRLRLFPTNLARAPPLLASALPLFLLLQLLAQNVSAIAHDSLYCETDKTGRHNCAEPSHYILKLAGRDDHLANRYADEHGMAVRGEPFLDSHYFIYPKSGGELRRRKRSLDQLVDREVCWPSVRCRSKDTASDNDQWYLVGRAVGNFDMNVREAWLMGYAGRNVSISILDDGIQRDHPDLVPNYDPSASTDINDHDSDPTPQNNGDNKHGTRCAGEVAAVAGNNVCGVGVAFLAKIGGVRMLDGPVSDSVEAASLNLNQQHIDIYSASWGPEDDGKTFDGPGNLAQEAFYRGIKAGRGGRGNIFVWASGNGGSRQDSCSADGYTTSIYTLSISSATYDNHRPCANINQPAIVTVDVPSGCTKMHTGTSASAPLAAGIIALALEANPSLTWRDTQHIVLRTANPNPLLNNAGWSLNGVGRRISNKFGYGLMDAGALVKLARVWKSVPEQHMCTYEYSLDAPRPRPIQGRFALNFTLEVSGCLQGTPVLYLEHVQVITTIRFGKRGDLKLTLFSPMGTRSVLLPPRPQDFNQNGFHKWPFLTVQMWGEDPRGVWTLMVESISNNPNIGGMFSDWALLLYGTEEPAQPSDQRYSPYAPSAFRRPGIGQALTSQNETTVEEASTIRFGTLQSVGDCHPECLGCSEPRSQSACFSCHHFTLTLRNRAGFKCVEHCEEGFYADGDKCKRCATDCETCSQAELCDKCHDAKLLIDVKHYGHLDHGRCVETCPSGLVADYSLTIQAKCVLKKNSCSAGYFESAQSVCLECDHSCSTCHGPGPLQCDECAQDFGNRTMGYCRKCCSPDQLTQKDLHCEDCSKSFAAASRDLLSLSSLVGNFFTIVGLVLLGTVLYYLCRQLICCCVGKGRNRSPSNLEYTPLTTIGDDFDSNNVNGKRNKGFELVADESDSDSDNTGSLVLEGENIVSKDGVDIGPKENIEADRITRRSGNPEFLRCMMSSSLVLSPKDSCYGLDGTSQVIGCTPIRLEDGHLTELRSLIASLPDSIRSSSTEEKNLERFEKLVLLYSEEPQLLDPALASLVDDLLKFVEWHSPPSDGTGRKLSLLTSAALVRLRTLSMVRGHKFLMRFLPHEFELFEPVLEILPWVGISFGLTLTKDLFTFSRAQMQRDGGDVEQRISICLDIFQREMASIGELAVVPTLLAQILTRNADNKRILTPRFDAFKRTFQGFETESDGGVPLISQLKLLIAILKQGRRLELRPFAFDLLCALSPQFVRANCPNILIRDLIAKLLQRLALVLLRPRLAPWRYHCGHRSLEENLRGRRGQTEAVESDRKQRTEEGDEEGEDESAVHYDQVEILLGELLLKVTDKDNVVRWTAAKGIARICARLPRQMGAEVVSSVLINCFGESNADEAANSWHGGCLALAELCRRGCLLPDQVPKVVVGILPRALTFEQFHLGFTQAVNVRDAACYICWAFARAYEAELLRKLLSPLAGILLSVALFDREVNVRRAASAAFQENVGRNDSFPHGIAVLSMVDFVEVARTKHCYTELAVKVAAHFGYFVRPMLDHLCELKSVHWDEMVRKLAADSIQRIAVFDSDYAFGKIFPVLCDRLRSADPVVKHGAFLGVSGLLLALSGKHDVLKYRDLFFSAVTDQCVSLGHHRSKGFSLIGKSLCRIIESLCAIGCDLTDEQLIQFHDILDIVISDSNKQMAEYAAAAFPTLMAFYKNGRFAFLVDRIRKKYFSEVVGPCQNESLRVSCIIPLGHIHADFLCSQFDLTTDGATKSTNSFLGVSVLQKLKEAIQDLRTPKWKFTPPNYDLTIVSDDYTTTTNGDIGRFARLQAVHAIGQLLPLAFSSAPFPVSQFQLNKAIGKVVERACESIDDLREKACKVLGELAKLDEKHPLSAAIVERERLISIFTLASTTNQNGTTPPPPFSSVDWRHSQGFLRLAPLLDSPTYGRNALAGFVLSAGSVCSWTSQNAFLAIASHLKPNKQNVQFLNNFLSELLVVYSAIVSRHGDASPVLFLFRTLLNDRQLQRIEAEPDKHREFVALCELSIKLALGKGRPKVKTLAVSVLGSLLQLSKRSQIYRRVLFLLLSLLDSPYASLREQAAEQLFEYFSCEASDGGQEGEVGIETGMALELLTGTDWSKGKGLADTKRQISDILLTEMTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU47</accession>
    <name>A0A914GU47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11364.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11364.t2"/>
        <property type="gene ID" value="Gr19_v10_g11364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037318431" evidence="1">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11364.t2"/>
        </source>
    </evidence>
    <sequence length="226" mass="25050" checksum="25BE9417F68E1763" modified="2023-02-22" version="1">MLFLDVLFLLSFLNPSIYCARIGKKLPSTSPSKKLDLPKRPLNAYIVENGKHAMVQNKSIQIWGGNDPKNSSITVKYHILRPPFAIKQRGGVILLDNGTSWLDWHRGRPSIIQMVAASGHAAVAPELEWETDVGGRAILKIIEVTADQLDAFVLLNGSGESLPRLRTFREDMGNGERPPVVVVGTTVVDGWTGAKTVEMDWDPKSLENGQRVAQLLVNLLDWVHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU48</accession>
    <name>A0A914GU48_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GU48"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11225.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11225.t2"/>
        <property type="gene ID" value="Gr19_v10_g11225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="744"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11225.t2"/>
        </source>
    </evidence>
    <sequence length="797" mass="92736" checksum="391290528250704B" modified="2023-02-22" version="1">MWDYRPRVVLARMHLYKQICPIWDSREIRYSIMPRKTLLSPRQRSTRRQTLNCLTMNLMEGKGFSESEIHSKVNEYRKLLFNEFESGRLDMDTELDVRNTHSRAKVAKDNRDKWRSALGIDAAFVDGSSLEKLKKASDSVIELTKTMDKKNLDKEMEKSLMEKLMEKIKKEKEKKKERKKMRRAMRKESSSDSSDSSSDSSTSSDSDDSSSTTTTDSSSEDERAKRKGKAKRKRSEETKVKKEPEQNDPSTMTLNIEERIAIEKEFTSLSFGELNSEKVRVGSRIQHLQNELSELAFHNYRTYVDVGRTAEHCREMFVEMNGFMQRLLLEFPDLIAGIKQAREDSERIFEEYKLLNDVESTNNFIWQVLKLPKLMERYIRTGRYEQAYSLTNFAISLKQSKFTQTNAMLKNVVEVLIEARHNLLDELFSKFAAPIDLARSIQIVNNIRKIPYISNLQLRESILQYRDIYMDKHVLYAMSEPDFLFRIIDIYRECMYDTIVLYLAVFPDCEAQRKFASSNEDPRWERWTGSSQTFLLQSWAQRNIEKLFSFLHRSEVKNCLDIEVMHSKLMREKWKQRQIALQRLDLIDGDIFENTRQDIEDSGNSAIDLGILSAPLELCIWDDICVFGNLIIDVLNDLRHSLSIVLIRQVFGVILLSMQNVFKWVDAFLSAPDGILSAKRAISLLLNGQFFRSSHCSVEAYREAFKLRSKELFVLCKHESVFNEILADVQLNENAANSEWQNANEAEKDNSDGWERLGKEGEVTTEKSKASEPMKLVGEMEIEGEAEERSAEDQIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU98</accession>
    <name>A0A914GU98_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914GU98"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1128.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1128.t1"/>
        <property type="gene ID" value="Gr19_v10_g1128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1128.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18503" checksum="7F98B29D7CA49D09" modified="2023-02-22" version="1">MAVTLHTTVGDIKLELFCERCPKTCENFLALCASGYYENCIFHRNIKSFIVQTGDPTNRGTGGQSIWGAPFEDELHDDLKFDARGMVGMASNGTNTNRSQFFIIYEKQPTLDLKHTLFGKVIDGFEELEELENTKVDARYRPVVEQRIRNITIHANPIADGAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV28</accession>
    <name>A0A914GV28_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g11452.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11452.t2"/>
        <property type="gene ID" value="Gr19_v10_g11452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06966">
        <property type="entry name" value="NR_DBD_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000042">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF494">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER DAF-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="706"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="610"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="818"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="877"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="961"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1283"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="349"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="435"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="986"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1157"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11452.t2"/>
        </source>
    </evidence>
    <sequence length="1663" mass="177011" checksum="AB80ECE83A1D2119" modified="2023-02-22" version="1">MINNNSSNNNNIVTTTVVTTSNGMGINNGIITGSFGHQMQSNTLATSNSNNNSSSNNNNSNATAAALLVAAMTAASNSPPELHHHQHQHQQHHQQQQQHLAAAAAAAAAVAHQQQQQLSPFSPQQMLAAAAAVAASPPNLAAVHQQLSAAAALYNNNNSNSNSIGSPAAVNASAFSRLLPPSPQQQQQQHMAQSTATVAALSQLIGAASIPSPQQFSPSMLQPAPSTAVQSSHLGKLDSFFAPGSPAAALLQLELLRNTTAVVPPTTTTTMPNGSATSGASAHYAAQQHSSPSQQQQQQSNELAAALFASQFQRHATQLLGGPASPAAAAAAAMSLLSPLGIQHHHHQQQQQQQQQQQQQLANAAAAFIQHHQQQQQAQQMQQQQQQQAPSAFTPLLQQQQQSSAAALPQAVPLTSSPTPSSAATAAAAVATVISTPSHHQHQQQHSPLLSSSSSSLSSSSSSAAAAGNSTTCTTPATTTPTATTTTTASVAAGNDGGGGNNSAAGVSGAGGGRHRNSVQQQLQPPPPAPLRKIRRRRPKEDKLLMPRRSSLPHGVLFVKSEQHNNNNSSSDAVGGPCSVGSAIDEMNNSSSSMHNNGNAIVKMEGVEQLQSPLSSTNHNSNDSSCSSINISSDVGTMLSGPQQQQFGQQHQHQQHQQQQQQQQQQCSPPALLLHEQQRRHAMMLDDDVTTMMAVDEGEEGAQQRQKHCRVCGDSATGYNFNVISCESCKAFFRRNALRPKEFKCPYTNECEINALTRRFCQKCRLRKCFAVGMKKEWILSEDQLKRRKNARIKGHQHQQQQLLQQQFDAAAGCREMVQHQQQHNHNNNMNNNINNNSYHAELPPTTPASSVASSVLTPGSAGGVSCGGGLGGQQPLTPCFDSMPPSSTTSSNTFSPPQNLFHHHNNNSTAGVPHHHSHQQQHSPLASTVLNNNNATVANDTPPLTLAALSAIIVGTSPGQQQQQQQLSPANGGAKLSIENSPAHCGGGGGGGGGIGTMETTNKVSPYSLGIQSPPTLLPTIGTTNANANSNNNGIGMHDHQHRQYFTQQQQLLQAVLNGVAAAGGGPSATAAAATLADTLALAARGGGQQAQQTAAAVAALHQLQQQVAQQQQNCVGGLSPLIIDQYNRLMMLSQQQQQQQSFAATPTMPMPMPMPMAATTTTTMSPPASSLYHQQQQQQQQQQGLVHQHHQKQQQQQQTSPKVKHAVGGLPSDVEMTCADSFVDAAMPSSISTSVGAGAGGGGIVVSSPSSMMAHFQRMDSQQKREYFKRHIQNTIQDELDVAWSPPESSRTTPPGAAVPPPPPQALTTPFSCSGGGAGGDHPLPTAPTATAPLLASSANAADIVVPTSSSSMAPPLPPTILFKDLRAFQLNSLEARDVETVKAAFLLMDEEFRKNGSNMMCSFKDTSDLMFLLDTMMRRLVKVTKKLPAFNELSHSGRFSLLKVAMIDMLTVRGALSVDSKNACWKRALMSSSNSNEIRLNFNILDQLLNGSMQTQRVMAFYTELHQTLKTDQMANNLVILIMLFNHHIDTELSAEDKSFATKNHATYTELLKRYLESIYGPEEARQIYETVPKAFITLNTVSEKAKELFKARVPKEDAQMLQHIKLAAEIFPTEAENSSATSKVAAATAAADQLQQQKGDCNDSNTTIINIKIKQEQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVT0</accession>
    <name>A0A914GVT0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVT0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11651.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11651.t1"/>
        <property type="gene ID" value="Gr19_v10_g11651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11651.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21157" checksum="75A2C61C77CE7043" modified="2023-02-22" version="1">MPILTESTNENTTAEQVKNNNNLEHSRQKMKMDELLESIEEHQKLADANETLQHKVVKLEKTQKKQQRNIDNLHKSIAALTVGQQQKNGPILPPPNSRSERAARHRGLSLSGRISLLAIPKGQHGTLASGSSDEPSRTHKFNRSYTPYTGPFKYVDTMKMTDRVFVNYQQKMLSAKNEASNKAPPNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWK0</accession>
    <name>A0A914GWK0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain roadblock</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWK0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11835.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11835.t1"/>
        <property type="gene ID" value="Gr19_v10_g11835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000009">
        <property type="entry name" value="Dynein light chain roadblock"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016561">
        <property type="entry name" value="DYNLRB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009998">
        <property type="entry name" value="DLC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="11">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11835.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10841" checksum="F190942631056FCB" modified="2023-02-22" version="1">MSSEVDETIKRIQSQKGVTGVIIMDNIGRVIRSTLDDDTTTHAGLIQQLCEKSKSVVREMDPSNDLSFLRLRTKKNEIMIAPDKDYLIAVIYKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWZ3</accession>
    <name>A0A914GWZ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12119.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12119.t1"/>
        <property type="gene ID" value="Gr19_v10_g12119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12119.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8228" checksum="57A577B11D24AF7C" modified="2023-02-22" version="1">MSRWFKPKPWTCGTSRRLHGDAISGSVAEEVGATSLKNVSQTMVGQLKGLKTGHKEPRRTACGTPFNGNGITILACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX16</accession>
    <name>A0A914GX16_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GX16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11183.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11183.t1"/>
        <property type="gene ID" value="Gr19_v10_g11183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000941">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF260">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037310614" description="guanylate cyclase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="526"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="920"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11183.t1"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117641" checksum="D830A73B9668F762" modified="2023-02-22" version="1">MLYLVHPLLLFFFLRHVSLQQNDSSTISATSNSSRSLNATINHHPTNGLKGRFSGNDTSETTTSRSLELMNNPKLSGFKVRIGHIGAVNVMPKAEQILEICRKELWKEGVLSEDFDVEIISQMGCGESFEGVAVGADMFHQQNVKAFIGPYCNAEMDAVSKMAAFWNVPIIGYMAANNIFSDKNIYKTLARVSLRTTNSLALAVYFLLRHYNWNRVAIVTNTGPMAFERTQAFEEVFHSKHINIVKKVLFEENADAKTILASGYLEDLKNSARVIIGVFSSTREMTKEFMQAVSSANLKTHEFVFILPWLQAEAKDSSPWIGADGQIIQNVRDYFTGSIIIDDVNGFDNTILAPFKERIESNGLLVDNLNLQNIYGYIHLYDALKLYSLAARMALNETGGNPNVTIDGRFLWNKMRRMQFPGLVSAEGVSSGLVVMDDLAERAAVYAAFYVAPNRDDVMKMVEMAPLPSPNCDGIINKSGCFELKLADLLTGFWPSADGRLPPDEPVCGFRNERCDYTLMIIIGILALVALLGAAAGFIFFRILENRALSRTSWRIFRDDMRIVSIEEMKSMLSIGSSKTKMSNMARFAKHHAVIGTNTHASFHLYPQRRPISFSRIDLQLLTLMKQLVHDNLNPFMGIAFNEKDELLVLWKFCSRGTIQDIIYNENVTLDSKFHAAFVRDITLGLEYLHMCPIGYHGSLTPWACLIDRNWMVKLTDYAIANCMERWEKSGCNFEETLKDGEDKSGASQTTNVLYCAPELLKNRDQNRRRGMEQVWLKQSAARRQAGDIYAFGIVMYEILFRGLPFPEGADLAGKSTEENSTELCEYVRDGSKTYKPAIQDRSQVHPDIAALLQDCWSNNPEIRPSIRRVRLNTENYLKVKGSLVDQMMRMMEQYANNLEKLVQERTGGTRNWMTFKTASVMFSDIVGFTTLCSSSTPLEVVTMLNTVYTGFDDLINKHEAYKVETIGDAYMVVSGIPQEIGVRHLMHLSDIALEFMAYLKHYEIPHRKPQKIKIRIGLHTGPVAAGVVGLSTPRYCLFGDTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXZ8</accession>
    <name>A0A914GXZ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g12184.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12184.t1"/>
        <property type="gene ID" value="Gr19_v10_g12184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000411">
        <property type="entry name" value="Ecdysone-induced protein 74EF isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052091">
        <property type="entry name" value="Beta-ala_Activ/Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394:SF1">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="8">
        <location>
            <begin position="150"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="1756"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1224"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1371"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1512"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1245"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1377"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1512"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1537"/>
            <end position="1548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12184.t1"/>
        </source>
    </evidence>
    <sequence length="1867" mass="206406" checksum="AD9C0C48ADC494F3" modified="2023-02-22" version="1">MLNTSHETGEFRNEQVHSLKLTKIPRLRSFAIHPILPSSLRSDCIDFIEGLILKVSNKRLFSALLRVLPPLPSEFDHLKRINGTDVLVKIGTTSIANDEQIAIEKVLGEEPELSIRLIPRRKPRGRAQLHLFREKWPMSFHKDVKLESIMNGTLISESESARLNELFVHAEQLKGALFYDPQNDRIVAEGTHSNERPLAHSVMNAIESLSAKQAKETNEKSAQYLATGFYAVLATEPCTMCAMALVHVRVKRVFFGALNEKSGRPMFSKCSFSMRKSFRVNELSVDRNGCIQSNILSPKIFDDALEISTTIERFLLPTCASSAKGVVAIVAAKSAFLVSMVVGVVETGNAFAIFEPGPSNYLEERFARFRIKFALFDASLPLDEDAFRDTAFVEAGRLKIGHLKNGSGDTGTFVMEQQEILYAIQTSGSTGIPKVVLVPFSSIMPNVEDFIERFSLSASSTVLYATQTNFDPSMVELLVALSVGCELLIPPPSAAWIGSVSRIILCDFRLSFVQLTPAVLQCLSTDILRHIFGRNSLIDTLLIGGDNFPLNLMKNYYTKQCPMSVYNVYGLTEVSCWASIHRFKTSDSEKYPPNLTPIGVPLLNTGLQISNDGILLVHGRNCIINFEEQQLNVPTPTGDIAFSMNCLDGKQCIFVHGRNKPNSILPNFATENEVMAALSEIVFCKLLYVDNCRFLFADHVDGTSAVSEDKIRSKLPKIQWPTRTFWNVDKSARLTENGKVNEQFLKQFVMSKYRDEVSLQQFLVDRFAILTDSISTRKSLRTLGIGSIEAAEIAFLLNKTNPSVDATDTLRFLLDERNTLGDFLNRFSLMINPNERGFEEQTNYGRMLQIASCKFKVEQKWAENLGKCIDGTPICHEGIVYAASHSGILKGVQLSTGTVMTSIRYAEDRFEAGVSAVGTKYIAFGGFVGCLYLFDVAQPDAKGAAVVTVDCGSEIRMTPAFDAKTNDLFWGSYDGWVWKLNVQTKKVVKFDACGHGFLRTNPLLINSLIVFGTLGAFIVAICKNFQCVVWLRRADSPIFAAPISFAGACLALSVKGQIQLLRPTDGHVISSFCVCDYGHFFDSPTPIGHDRLIISTGGNSLLLLSYQLHNNNSFALLSRFAFPFQNECVIRRPVLFNNFAFLMTNKGTLFRIPLDALFGRPAECVLLDCVFSAQVETFGLPLLLEPDRSEEDGAADEPSSSFIVVFGARDDLLRAKLCCTPTLPGPKGNRASPSDGRIVRDAEESGGGAAAAGGERGSGRRMVAVGRRNNSSSIVVVVGDDHADDDDDDTPGFHLRFLSPSVLTTRRTIFFNKNDHHRRLVAMELTTHHNSTLNALLLTGRHYSDYALDARSEQTQRSAIANVQHVDCLEQHRNGDNGDDDGEESEEAFGGNGMEEQPRIVRPVPRKPPPTFLDPSAFARINGDCASNAETFARFAEQLATRRTSAPACLDTQFRGQAFSPNDSVGLTCLKNFETNLYLCQQMFGRDLQSLSHCNTINNPFSTGQNIHLSHLLKSSPSSSSSPDSGLGHEMNTFVHNESSSSSSSFFPPCSENSSTSTGSTDAPQNVFHVPFVNKECVGSSCAAPSLGKVPTTNVHPCGVFAAEFDTAALGSWLSLLQAHSSATSAIISPAFFPSTAAIHNVLRPSDRPPPPPPLPSLAHHPAALSSLVQQQLVAAVRSATAAAAHCQTPRVHPYHRQHHQLLQQHQHQQLPFPLRAGVRRRSSEPTILLNDGGVFASAATLPGARRRNNREGHVTYLWEFLLHLLSSKDYCPRYIKWLDEEKRIFKLIDSKIVSKLWGVHKNKPGMNYETMGRALRYYYQRGILQKVEGQRLVYQFMLIPKGSVDPNFIEEGPSMDDENRREIQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYS4</accession>
    <name>A0A914GYS4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="4">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">NADP(+)-specific ICDH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYS4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12433.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12433.t1"/>
        <property type="gene ID" value="Gr19_v10_g12433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="337"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12433.t1"/>
        </source>
    </evidence>
    <sequence length="704" mass="77913" checksum="442999569EDA8EB2" modified="2023-02-22" version="1">MGLPESTDHLPSKRAAADKAQVSGLLDSLGIECGPSIVYRLGRSFNPTQKSARLVKVLLPARAFQRQALTAWRTKNSTIRSSASQLKNIQIRESLTREQLEERRRLHALCTGKRTKDGQDWIVYAGSVILRSELVETKRSITAYPIFFNNANSPTFPFYAIMSNDRSVYVNGDDGNNEPSGGGGNNEPGGGGGGNNEPGGGGGNNEPGGGVAATFVALVVTMAAVEVAAAGARVLSTTWTPSMRILVRLYFSLICVWNTRSSFYYASISEKWFYGYHQFFYLHVRGGLSCFYSTPFHLKILFVLSLYDSDRLIGCAIIQRHYFSVSLTMHKIKVANPVVDLDGDEMTRIIWAGIKEKLILPYLDIDIKYYDLSIQNRDATDDEVTVDAAETKTGNILGGTVFREPILCKNIPRVVPGWKKEIVIGRHAFGDQYKATDIVVPKGTKFELSITKDNGQVERHPVFSFADSGGVVMGMYNTDESIRGFAHSCFQYALKKKFPLFLSTKNTILKRYDGRFKDIFQEIFQREYTAKFDALGVSYEHRLIDDMVAQVLKGEGGFVWACKNYDGDVQSDVVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGNPTSTNPVASIFAWTRGLEHRGLLDGNDALVKFAQTLENACVATIEDGKMTKDLAICIHGLKGAREGSYLYTMDFLEAVNDKFNKLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYZ8</accession>
    <name>A0A914GYZ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12421.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12421.t1"/>
        <property type="gene ID" value="Gr19_v10_g12421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12421.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27867" checksum="A68D31525076443A" modified="2023-02-22" version="1">MEASLSVLSHADGSCELWQKGRGRILCGVTGPGDVSSSRRIFDRANVFFSINRLATKSREELVAAVRVPSAGSASSSSALAQPVDHFLRSVVESAIDVGAYPRSCIQICTQELVMDGPGDAFQLNGLCMALIDAGIRMRHIFAAVIVGLPSGDGQQEMVVDPNQMEANACRALFTFVFKPSAILAGKLLGAHSVGQFTMDEFKNAIDLAERRCLTVFDFYRHSTVQKTPVCVFYLPLLTSQQEKCEKVEKIIRIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZB2</accession>
    <name>A0A914GZB2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZB2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11783.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11783.t1"/>
        <property type="gene ID" value="Gr19_v10_g11783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036834935" evidence="4">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11783.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27021" checksum="7121A3C1DCFBDE93" modified="2023-02-22" version="1">MLIKILAFCLLILKFSRAIENSDHLMTENVSDFDVIDKDADSLISYAEFQRWHKLAMSAEPRESAVLFGTHDKDADGNLNVAEFVPLAFELSRKPDSQADKVFKKFDANADERLEREELLKGDSVSEEIVDGLFQVADVNADGRISFEEFSSVANALESRVSPNAKNSGIAQSLLAQLDMDKDEGINGTELFEYAHKFGGKESRTETDKVLRSMDLNGDGALSLEELKAVARGADACRRHQTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H014</accession>
    <name>A0A914H014_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H014"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12791.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12791.t1"/>
        <property type="gene ID" value="Gr19_v10_g12791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12791.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13522" checksum="70B9289BAD300473" modified="2023-02-22" version="1">MPKWSQKFKKVVKMPKWLSQWPPDNPSEDNPSVPNPSEDNPSVKDNPSVDNPSVPNPSEDNPSVKDNPSEDNPSVPNPSEDNPSVKDNPSVGNPLEDNPLSTDGLSFTDGLSSDGLGTDGLSSDGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H166</accession>
    <name>A0A914H166_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H166"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12980.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12980.t1"/>
        <property type="gene ID" value="Gr19_v10_g12980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037549078" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12980.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20095" checksum="BBD09F052FB84D56" modified="2023-02-22" version="1">MFLSLLLMALGCLAPLSAHGRGTSGRGTSKMPPISVDLCMPVLPKPLQKLSEEEKNCLFTIYTMSKLFENKKVQKALAKQSCDSNDSSEPDIWLRRKKSNGWCELNMERINSEYGPVVMHAHGSIASINGARLFVKTTHNGIWIAIYQPNCQEESGEKNDTNEVISDTIKRVRRWALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H195</accession>
    <name>A0A914H195_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H195"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12711.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12711.t1"/>
        <property type="gene ID" value="Gr19_v10_g12711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12711.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8765" checksum="F28E55C7B577AD07" modified="2023-02-22" version="1">MKEKPFILVSCDDVLFDVFKFCGPFVLGLSGAFSAIDLTFWWTRILIQIWALGRKVERQLPIQQEPLPQSDRLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2V4</accession>
    <name>A0A914H2V4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H2V4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13637.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13637.t1"/>
        <property type="gene ID" value="Gr19_v10_g13637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036733353" description="Palmitoyl-protein thioesterase 1" evidence="11">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13637.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35887" checksum="786548FE956E75D8" modified="2023-02-22" version="1">MPFKISVLLLPFLWPLTLAANVKDPVPVVLWHGMGDSCCNPLSMGFIQKLIRTNVPRVYVRSLRIGASIPEDIGHGFLANMNDEVAKVCEQLAQDERLAAGYNAIGFSQGGLFVRALAQRCAHPPIRNLISIGGPQQGIFGLPYCPGSAALCAVVRRLLDRGAYTDFVQHNVVQAQYWHDPNPAERYRQANIFLADLNCEQLHCNSTYRDNMVKLRNFVLVQFSHDHKLVPKETASFGFFADNGTPTIIPMEQSAIYKEDRIGLKALNESNRLHLLSFNGEHLQIPTEVFVSEIIEPYLKDKSDDDRGGSVSSTSSESDEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3D7</accession>
    <name>A0A914H3D7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3D7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13626.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13626.t1"/>
        <property type="gene ID" value="Gr19_v10_g13626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13626.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12575" checksum="EFBE093F6AB5C7A8" modified="2023-02-22" version="1">MREWCSPESLSEPCIGRRRTPPTPDDLKPFMRPPWDKTDFPSTQIEPIDEKTDDPLDDGNDVLVTKQQAQTEYDHFMEACSKCRDSLKMEKEKRRQKRQFLIGICTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3N0</accession>
    <name>A0A914H3N0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3N0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12960.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12960.t1"/>
        <property type="gene ID" value="Gr19_v10_g12960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12960.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19056" checksum="0798E32AA9C5A3F1" modified="2023-02-22" version="1">MPISENRLLCKSTNKFRPLNMTSFSAVAAVPSPSSSSNQLHLVLRAAAPLSSAQPTLSTMPTHLSSQNEENNTQKVLAMPSRGQQSAESNAKSPLSESRCAADNRNEARRFVSPADFFSRQSLNASQMAGRPNTRHRFQQQNALFDDLLLAESERDGVQTTLTIRGTATATNLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3T7</accession>
    <name>A0A914H3T7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3T7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13392.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13392.t1"/>
        <property type="gene ID" value="Gr19_v10_g13392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF699">
        <property type="entry name" value="INTEGRIN-LINKED KINASE-ASSOCIATED SERINE_THREONINE PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="49"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="619"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13392.t1"/>
        </source>
    </evidence>
    <sequence length="758" mass="86597" checksum="5460177A63AEFDCE" modified="2023-02-22" version="1">MFLKQKKFVQQMRRIRYCTVCALRERASERKCRTDIWFWIRLRAFLEIFYWLEPTIHKESARRCALYALFDGHAGRRAADYCAEHFAQMFVSVCKKYIPPKNALSAFERSIRKIFVETYKGIDDGFLTEARKQKPTMKDGTTATAIFLMDKTLYCANIGDSKAIVCRHKSEKSANIPLQLTVDHSPLVFDERMRIQKAGGTVKDGRVMGILEVSRTIGDGQMKMHGVICTPDLKKLSLTPDDLFIILACDGLWKVFTPETVVDFVADQYKSLAKNVEFIEEKDSAGLWTKIADEMSAEAVRKGGADCERKEQLVETVPVAEVNCDNLNIIWPQLIDSIKKAQLISIDLELSGLGERAGCMRTMPERYKRTREATRTRSILSVGIATFQFNGIDTDQRRELRYKCRVFDLLALEERPFVVEPEALQFLSSHGFDFNRVLTHGIRYSKTDSKGGAFHSLWEEIIASGVCIAFHNANLADWFGEREATDDYYAMDCALWDSKYLAEHQQAQAFSCTYLDYVFRKAQRDNQRFFQNEKPHLTVKFAKLRRNVRKVTKFSQLNCGLKESFMSGNLANVQKQMLCQSYAQFGHCRYRMNCDKEHDVDFLLDLEDKRAQIRRERERRRRAKKEAANEKEESNAGGEDEEEESEEGSSGGGEGKKSGTKRKRGDDLQQGANDSIKVIKEVDHGSAPLSLDMPTRINRTVHVWTTSRGSHRAGMDAFMTGFAVLFFQLGHAYRNSGRLDCRQFCHPNGKPPAELGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3W4</accession>
    <name>A0A914H3W4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3W4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13913.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13913.t1"/>
        <property type="gene ID" value="Gr19_v10_g13913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13913.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13898" checksum="EC3D9125E78FB4E6" modified="2023-02-22" version="1">MAALPVVARASLTRTPLAAHLQRVRSAVQLVWEENQCENKCQEDSAKAKREKRENAKEETVPKEKIKSEKCHKMKLPKGEMPRGKSQNQGKCQAGNVPKGEKVKREKMPRGKSAKRGNQEGKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H537</accession>
    <name>A0A914H537_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H537"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13907.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13907.t2"/>
        <property type="gene ID" value="Gr19_v10_g13907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13907.t2"/>
        </source>
    </evidence>
    <sequence length="429" mass="46183" checksum="19D15A91BF6DB4C7" modified="2023-02-22" version="1">MVKHKVKTLPNSVFIKMDKTADDGSSSVFSRTIWASDRRHIAGTEIGAFLLLDGFGDDPAAITQFVADTLLKELLDSPTLAAIVSQIAKSGERWAWSQCQTFNHTGVIEIQIKRSPQIDQFISDTFHHVDSSAYDALFGNLLAGEARSGQNDEQRQQLSLMNSGCSAILALILGRQLVLANCGNSLGLFCLDSSDGLLTAVRVSELHEGSSTATATEAGGAAAVPFRCFGAFAHKTGGLKGMAAAATAAAVSVRPTIQRPIELYHSARFLLFVTAPLWRLIQRHFCKENDQSLDIALANFVAGAECHKEEGNWAQHIQSAIAKVLSGCAGEEMSSSLALAIVDFAKTDFDRGEEGQHENDCCSSTNVSNSVPSEVDWSEFNTHHLREENRRGAANGTLASNVQPSANVRPQMSVRKCRTAIPAYSSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H594</accession>
    <name>A0A914H594_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H594"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1379.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1379.t1"/>
        <property type="gene ID" value="Gr19_v10_g1379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1379.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="6987" checksum="8B808181FC98205A" modified="2023-02-22" version="1">MICLSHSSDIWHSHSRSTNSVDQSVLVVVVVINLIGWRNAIGYLTTGGDGDGVDGGGGSLSAFAQITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6L5</accession>
    <name>A0A914H6L5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6L5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1429.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1429.t2"/>
        <property type="gene ID" value="Gr19_v10_g1429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1429.t2"/>
        </source>
    </evidence>
    <sequence length="1023" mass="118377" checksum="1623AB2E458F18BC" modified="2023-02-22" version="1">MGDRRFMLTPQNGEGRLEFTQTFCRDCAKLNFDCTDLIMKHQKKDAPTKNGHYHPYTGGNNTPGFVGNKTNKFKVHLPKKLVFEGPGWMVGMSGIIYPNSWATVGTLEKQYVIVHLRDGRKYRFKVPRGSFLSPQQLERGIHHGMIAEMERLMTRKRAAFEEDEEEEGELVDVQVVEEEEGGLTGLQVAKEERKESVEAPLLPMSQTKFASEQAAERTRQPPLANVRPPEQRGAVRERELVAPNQTERLAQEKENERKRKAQKWIEDGRKETERRRQEALRKETERLQRMVNTTKEGAASKKKEEEKLSTPKQAPQQAVNEMLEKQKEEERFPKQKEGPGKKEENRLAKQKEDPGKKEEDRLAKQKEETEKKEEERSAKQPEDVGNRPNNGIERAVNPAGEEERIRRDQERKFKLRELELLKELKPYRGGWMRLVQGKDPTPDVHYLHEKDEYHFSNAVDKYRIHHPELAWDLPEFNPSAQIQRNIAEFKGLFEREVYDENYGSKTREEKEELIALVKGFRFYYMEDIGRFILKIFDNKISHITLTDQLAYVLGYEQEQQIINEDLAKYSVDLGGGVSHLCIYLNSGIIESMIFGNTFANLLQVIAVEGKSRSVVEKDFQSPLFHKIIAREVDVLDVEIRTLTGRSWSWPGATFIRNLKVHINQREVYDSNQLYSYKVYLDTELSYPIAAKDAYFGVAGYFRDTDLSKANDKRRKPLAESKAYQTISKLSADIFNQDLYMNSNVEIDIELALQSDDFMLHEEKEKDKFVLEIVDCRLFVKTVDLMDGLSLDIARKLDVEPARFGIRKSFMKSLFITGGRYDFSANLFTEEVPRRVIIGLVANQNYIGHKQKNPFFFNHHNVRDIELTASGRTYPQYPYNLDYKNNNYARAYHDAQEHLGLACTTESNGLSYSMFKTAFCLYVFQMTNSQEDSPGFELIKEGCTAGLQLLDFICSCERGEFGAKMDNRLIDKILFENVATRRFFMGTFPSDCLPECTRFPCSLIVNLSWQARLSLVRDLGQVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H949</accession>
    <name>A0A914H949_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H949"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15358.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15358.t2"/>
        <property type="gene ID" value="Gr19_v10_g15358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="484"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15358.t2"/>
        </source>
    </evidence>
    <sequence length="624" mass="70662" checksum="A39192FB980D44FC" modified="2023-02-22" version="1">MAECLECKAKKEGKYQFKLSDGSISSLIGHLRSEKHKNSEYKTKFDEMTKNLEKSVVKCRKAGGIENFVVRSSGNMTRLDKVIVNLICCANLPFNLVNNPHFRTLCKPWSEQLKDESHYRKLLPIAYAAVKEKMKAELEKCNSISCTSDIWTEGITDKWTRVVYTLAIQPFPGSHTGLRVAETLSTIAFEEMDNNEKILPFFRANCAAHLLDRSVKNSFGSKQGAISELFANCRRIVSRVKHSIKALDELKEVQELEGLPQHKLLQEMAVRWNSSLIMIRRLLEQRAAIDLISFEHRNFELTMQDGEWKLLELLQRLLTPLEEASLFFCKSPLSTKIPFARALLSQIRQLDLRLNGENDILQGIVEVEEMRTKLLTGIEERFSHLENEKLHAVSTFLDPRFKVFFAADKDLFTMHVKSWLADEQKDDENVADLDLFGCDENAFIAPPSKLQRTFLDSLSEIASTSKTAVQVQQGSKFEEEFTRFCSADLIGQELDPLDWWKINEGSFPILATIAKRYLTAPSTTIGSEQLFSVARDFFAQKMSKIAICIGLGTKQMPLGTPVGWDKGTYAYASHGYFLGHAVDGFSGRFFGGRPYIERKPKFGVGVIGCGVDLATRQIIYTKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9A3</accession>
    <name>A0A914H9A3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9A3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14448.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14448.t1"/>
        <property type="gene ID" value="Gr19_v10_g14448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14448.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19974" checksum="B4E59F9B9D3315AF" modified="2023-02-22" version="1">MMNQRRHTVPPSEDAIEKIKKVLNDPLPPSTTDKYAEMLKRLLELNLGSEYDNFLKNLAKKFSTNRPPDNDDDGGGAGGASQYSTDNNDIVRAAAQLFIAGQQNSEQADLMLLPLGAARNIFFLTRNAVGKFLSSDGQPRLLSKSNVMKEQQPLDLFFVRPHEDKVLSFIRPLESGTGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAG1</accession>
    <name>A0A914HAG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15273.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15273.t1"/>
        <property type="gene ID" value="Gr19_v10_g15273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4010:FF:000002">
        <property type="entry name" value="Held out wings, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000028">
        <property type="entry name" value="protein quaking isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15273.t1"/>
        </source>
    </evidence>
    <sequence length="509" mass="53703" checksum="D8F079EC3DB3B88C" modified="2023-02-22" version="1">MMEGQQQITINGSVLATKIDPGHPSIENGFGQRSSTSTTNGDQNGYSNGIVTAFRSASTGASMNKPDLDYLAQLLKDKKQLSAFPNVFAHAERLMDEEINRVRVSIFQCEFTHEPLQLPEPVGEVAVRQEKVFVPIKQHPEYNFVGRILGPRGMTAKQLETETGCKIMVRGKGSMRDKKKEETNRGKPNWDHLSEDLHVIIQCEDTPNRAELKIARAVDEVNKLLVPAPEGSDDLKKKQLMELAIINGTFRNSNGGTSAGPANCASPSSTAAALANKGVCSAASLLQLDPRLLGCSTTAGLTGSPLIMPSAAAAASPVMSFQSTNGQASLVAMNNSLAAHALALQLATPAQTAAQLFGASPYSGGLASVTQAASTALDYQQQLLALGHFQQQQQQQQPQLDAAQSQQLSALFQQQQIALSALQQQQLDYGGGGCVVGYGSGTFVGAAGNGLAKAEGANHSSSSSSVGAGGYILSGQRRFVGHSRDNAHPYSGGGGSDRSEHQVLVLNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAV1</accession>
    <name>A0A914HAV1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="7">eIF3b</shortName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAV1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15816.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15816.t1"/>
        <property type="gene ID" value="Gr19_v10_g15816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="393"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15816.t1"/>
        </source>
    </evidence>
    <sequence length="710" mass="81373" checksum="921A55720F81880E" modified="2023-02-22" version="1">MAAPTDVDDHRFSDPEGFEDDVEDDDVIRDLLYEEPRESQYEECCIMVFNIPTISSDRLPKLRNVLAGVFSIQNTYKYNDNYPLSEDGKTKGFCFLEYQTKEAANAVLAVCDGHRLDKNHTFAAYPFTAVRSMKEPEKDWKKPERQPYVDLGDPWSWLQNPKCLDQFAILYESGQGSLRLDMFWNARTGEPIVVENACRDNWSNDLFKWSTHGTYLATMNNDKRNQRLGAVIWGGEKFDKFQRFSHEGVNYMEFSPNEKYIVTYACDQNSNRDNENCLRIFEVFTGELKKAFSPSLRSAGRLHDWPFLKWSHDEKFFAFCRLRGNCVNVFSTDDFMLCDNKAIELEGLVCCEFNPTKNLIAYYCEERSSANAPAEIGLLDVQTRTKLRASRTFSVSQSSLFWQKSGSYLAAHTERYQKMVKSKEGEIKYTGTSSHVEIFDCTDKTFAVQSIQLPEPFVNLAWEPKGNKFCVLVGTGQKVTPLIYRLDRGKPVPQLIGKIEASNGLNTAMWAPQGGWVVVMGVNTSSGVVCFIDANGITEATKAKTIEHTSLSQGSWDPTGRYFVTCTFGGKSRYETGYRIHSFQGRELRRKAVDSLLRFKWRPRPPVSLPEQKVREVRKSMKQQSTKFEEEDKKELLKVSKEIIEQRKRALEQFSSIRAAASRAHAEERSERIELRGGIDQESVEKDLVEETITVALNTEKEKIKDEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAV7</accession>
    <name>A0A914HAV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14894.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14894.t1"/>
        <property type="gene ID" value="Gr19_v10_g14894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037019516" evidence="2">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14894.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11449" checksum="06A599D5A7C0E507" modified="2023-02-22" version="1">MLFYKLFLLNFLMTLIGIAIGGGTISREQKHADNTFDVGKPSAQQAARINEQLIVLHRQPIKIPEGIIGNVLNSLSQQYTNAQPATAQTGRDEAWINAGRDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC25</accession>
    <name>A0A914HC25_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HC25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15971.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15971.t1"/>
        <property type="gene ID" value="Gr19_v10_g15971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="94"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15971.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25825" checksum="382F32C52E0CA838" modified="2023-02-22" version="1">MSTSNDPVSEFLAREQTALAELGDDFVAAPLPQPDNEGIVLTNGGSDFGSDVNLNAFDANDVHSPVNGINGSLRGSPAFSHSHSQQLEKEPEKIRKWREQQKEIIAEKDKIEEQKKEDLRQQAKKELEQFYAQRKEELEQRKKLNREREIALKEDQSLNNQQESAAVVWERVARMIESGGGTGAAICGTGKGTKGAQSVASGKDTSRMKQLIVSYARGDQMGDKSPSPDKEAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCG4</accession>
    <name>A0A914HCG4_GLORO</name>
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        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCG4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16240.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16240.t1"/>
        <property type="gene ID" value="Gr19_v10_g16240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="36"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16240.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26663" checksum="D7D55A66DAF8B746" modified="2023-02-22" version="1">MANVQIQRRRRLPLELQCEVISALPFQHGRRMLFLCNPIATNCIVLVRKQKGHFENRWDSTACHNNLALSEPDRLTVQYNGETNWQWSSVIAEKPMSNNPCFEMKILDQTDRVYIGLAPKQIPLIDLIGYRKSSYACSSRGNFLGHEVNGCSHYIGRPFIRGKPPFDVGDVVGCGVNLENGQIIYTKNGQRFDTDGLLVDSAGDLFPSVTLFQSGTKIEANFGPNFQFTFPMAFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCV6</accession>
    <name>A0A914HCV6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCV6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15443.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15443.t1"/>
        <property type="gene ID" value="Gr19_v10_g15443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15443.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33172" checksum="59849C2F5DE15730" modified="2023-02-22" version="1">MPKSDSLVGRVKHLLDTGNAADVHFLVGEGPKKELLSAHKLILMAASDVFEAMFRFDAQNAKTAAGGKEVKPVEVPDVKVDAFKAMLRFIYADDSSGLNGDNAISVLYAANKYDVSGLIKACVNFPKEKLGNVFLLIDQARVLGVEDFARNCLDYIDKKAETLLRSKEFFLQINQKLLCEILDRDQLIVCEELRIWNAALSWADEKCRQNGKEPSAENRRAMLGPALFKIRFPLIPQMDFSHNVVPSGVLTSDELVSVYLHYSCALSKLYPLQFPTQRADYITPLQRRAVGVRPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDC2</accession>
    <name>A0A914HDC2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDC2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16309.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16309.t1"/>
        <property type="gene ID" value="Gr19_v10_g16309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037525399" evidence="2">
        <location>
            <begin position="24"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16309.t1"/>
        </source>
    </evidence>
    <sequence length="742" mass="86971" checksum="3EA232274828A3E4" modified="2023-02-22" version="1">MLCSIAAVLLLFILPLFTVFVQSAVVHRCGIGFGGGGRCPQETGHRRHKGEGRPIGIVAVIEGGGQRAEKLWHRKSKIFEEQRLLEKKKKAIIQLQPGIWRFGGHQQQQRRGPIILIKRKYRFKIPDKEVAKRDRKKNSTRKRRPKMSREQRKWRRRSIEGPMNERVALEKRATGQIRTMRKLYPIYGLLRHERQRCRGTKEAERKCGGKKRAKEIKKSRRAEEAQRERESKGKAIRSMEGKEQETERRKTVRRWQTQGTGGKSEQTETRSRKKSSIKRRNIKAKKDITEEEEEKEEKEMKKTIRLWKTERKREQTEIPSRRRSSVKRKEMETENGDESGEEEEVIKTEKKKIIRWNSSETMSKRKSSIKRKDTEIESDTTEEEEEKEIELERKKIARGEREETEIPSRRRSSVKRRETETENGDGSGEEEEEEAKEKRTMVRWHSSEGKSGSSPGRRESSIKRRRGKGSRAVKEKETSEERRKTTSWGKGVDKMREKEREWTRVAEEAEKRQKSIINKLARERMDRDVKEIENEEERQNKETGGSAQKKEWKVTERAKNELMRRESERRETERGTDAEHERFDVGPNVVAKGRPRATWGERLNSAGSYVTDRIGTAGGYLKNIWHRARGISKGDQIIAREHSGEERKNGAGGHQDGSASVEQQKQQKQLHPKHRKSLNRSNIYDGRAINTDRSAKNSIENSMRTLTIKPTTGWKRRKQSERRNKPPEGLPKRKRTRAWKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDQ9</accession>
    <name>A0A914HDQ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDQ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15686.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15686.t1"/>
        <property type="gene ID" value="Gr19_v10_g15686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15686.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23012" checksum="DF9778536D74C640" modified="2023-02-22" version="1">MTMFGQSTHNQPMPSGTVGVPSLDQLIALTNSACHRMETQLGLGLNLRPDGSSATGQQSKAKAEPTKPELFKTQLCNHFSIFGTCRFGSGCWFAHGMNELRACVPPAISPSTPSSLFSVSERRPRAVAQRATPSLLLGNWDSVGGGRSRRQINIFGHGCLFGGGNPNDLRASVSGGSSSPPSSLFSFSDRPSRAVAHRAPPSLLLGCDFVGGRSHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDS6</accession>
    <name>A0A914HDS6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDS6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16578.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16578.t1"/>
        <property type="gene ID" value="Gr19_v10_g16578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16578.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="13142" checksum="D452022ECB1D94F3" modified="2023-02-22" version="1">METRKRPKPPERIEMECKIPEEAGRETNLKKPEETKTEMILVPEKMEMTKRPEPPERIEIECKIPEEAGRETDLKKPEETKTQKILVPEKMEMKKRPEKPERMEMECKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEK2</accession>
    <name>A0A914HEK2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914HEK2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15898.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15898.t1"/>
        <property type="gene ID" value="Gr19_v10_g15898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000021">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="16">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="170"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="413"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="13">
        <location>
            <begin position="629"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="1010"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15898.t1"/>
        </source>
    </evidence>
    <sequence length="1102" mass="123122" checksum="4836B805959E9359" modified="2023-02-22" version="1">MSIDNSKGLSDKAALIPSFLKTKGLSNQHIASFNYFIDVEIKNILQANNKITSDANPVFYLKYNDINVGIPSTEEGFNVLNDKITPHECRLRDMTYAAPVYVNVEYTRGNQKVVGKNIVIGKMPIMLRSSRCVLSRLTTEEEMAHANECPYDPGGYFVVRGSEKVVLMHEQMSKNRIMINRNMKKELICEKNRYYLAHNQLADDIPVGVIFKAMGYESDFLIASSVGSEEDFVAALGPSLDESSVLGIVSRADALRYMTAKVRKKTFGGPQSAVVRTSQEHDVLDFLANSMICHIASVGGNMKMKAVFLGLMIRRLIEAEKGVCEADDRDFYGNKRIELAGSLLALLFEDLFKRFNSELKRIADSHLNRNLAAPLDIVRHMRQDLITNGLVNALATGNWTIRRFKMERHGVTQVLSRLSYISVLGMMTRINSTFEKTRKVSGPRSLQSSQWGMICPADTPEGESCGLVKNLSLLSHITTDSDEAPILRLLYNFGVQDVRPLKFSVIHDRRFHTVFLNGSIVGVTDDVEKIIGTVRMMRRKGHLGAFVSRRGPTLSSVYYCGKWLSMSQAVPYRVQEGRKTFDYLLAEGCIEFLDVNELNSTRIAVYEHQILAQTTHLEIEPFSLLGVVSGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQQKRIDSLMYLLVYPQKPLVKTKTIELSNFEKLPAGQNAIVAVMSFSGYDIEDALVLNKASLDRGFGRCMVYRFAKGTARKYANQTYDKIMGPSLDATTRKPIAKHAVLDQDGIVFVGAKIMPKQVLINKSMPLMQSEILPTGNVAGFNHNFETKDVSIPYRGAMNAVAERVLLTCNDEEQYLAKVLIAQCRRPELGDKFSSRHGQKGVCGLISPQEDMPFDQNGTVPDLVMNPHGYPSRMTVGKLMELLSGKNALMGPCHQWRMHYGTAFAGDDVETVSKQLAAHGYNFLGKDMLTSGSTGQQMAAYVYFGPIYYQKLKHMVMDKMHARAKGPRAVLTRQPTEGRARDGGLRLGEMERDCLIAYGASMLLMERLMISSDQFSMDVCSECGLIGYSGWCQNCKSSDAMAKIKIPYACKLLFQELQGMNIVPRLKTAKCTEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF44</accession>
    <name>A0A914HF44_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16408.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16408.t1"/>
        <property type="gene ID" value="Gr19_v10_g16408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16408.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8027" checksum="2B569744473B4CD9" modified="2023-02-22" version="1">MNSHNEYASTAADGLVKQNKVLVQSIRKFTAKLQTQDFIGILIFFAFLPMGFLYAVTFPLCFWFEPFSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF91</accession>
    <name>A0A914HF91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HF91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16828.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16828.t1"/>
        <property type="gene ID" value="Gr19_v10_g16828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16828.t1"/>
        </source>
    </evidence>
    <sequence length="670" mass="75136" checksum="C99F8B39FC0D7356" modified="2023-02-22" version="1">MEKKRKRLKVTTMVMNECCTYITAKVREIRKEPGLQDHHCFCASMITSHNQSYIESLRTRQTAALKQVLNLNQPINVSLAVEPEWKLLIFDRFAQDIISPLLSVKQLRELGITLHLLLDSQREILPDVPAVYFRAMYDSFYLNMTGPIPRPLLEELASSAVAGGTMQHVQKLTDQFLSFISLEDDLFMLSRYTKSSPISFYAINNPSTTAAQIDALVADIANGLFAVCVALGVVPVIKCPKNNAAERVAEKLDQKIRDNLRDARNNLFVQENIRAGHLSIHRPVLVIADRAIDLSTMMHHTWTYQAMIADILDMELNRVRMKDKNGRPKDYEFSTDDKLWTNYKGSPFPLVAEAIQENLEAYRRDEDEIKRLKDSMGLTDGETTEMVDIFGTAATAKLSTAVGSLPELLEKKRLIDLHTNVATALLDNIKTRKLDVLFETEEKLLTGQEIPIVETLRDCPDKEDIMRLILIAACSRSMSSAEQRELQAFIEERAVISDALHFVRQLRSFANLGGEAELHQGAGTKTVSMFSKLLSHSSRFVMEGVKNLVPKKHNLPLTKVVEQLTTDVKSGVGVVGITGGSSDFDPDQFRLFDPKLLQGSAANRDVRPTHAAADVIVFVIGGGNYVEYQNVQEWAKARGLQRCTYGCTEMVSPKQFVEQLNTLGAMSRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFJ7</accession>
    <name>A0A914HFJ7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HFJ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16511.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16511.t1"/>
        <property type="gene ID" value="Gr19_v10_g16511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="55"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="319"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16511.t1"/>
        </source>
    </evidence>
    <sequence length="721" mass="83581" checksum="624533F0E90922EA" modified="2023-02-22" version="1">MSVLISRYCLITKQVLRKFHKAPFEMEPLPQFIDERNRLFDDLMAVHKAELATKARAQITVTLPDGKAVDGISWETTPLQIAIGISKGLADKTVIAKVNGELWDLDRPLECDSTLKLISFEDDEGKQVFWHSSAHILGEACERFCGVHLCYGPPVQDGFYYDMHMQGEKKTIAQDDFPKLEGIISAIVKDKQRFERLEMRKEDLLKMFAYNEFKQRILNEKVQTPTTTVYRCGPLIDLCRGPHVRDTGKVKAIAVTKASCAHWEGNVNAEQLQRVYGISFPDTKQLKQWRTLQEEAAKRDHRKLGRDQELFIFHPLSPGSAFWYPKGTHIYNTLLTFMQREYRQRGFQEVISPNIYNAKLWEQSGHWHHYAENMFRFEIEKEQFGLKPMNCPGHCLMFDYKPHAYNELPIRYADFGVLHRNELSGALSGMTRVRRFQQDDAHIFCRKDQILSEISGCLDFLNFVYVDVFGFSFRLFLSTRPEDGYLGDLDTWNTAEAQLTQALDESELKWELNPGDGAFYGPKIDIQIKDALGRYWQCATIQLDFQLPQRFDLTYFDENKERHRPVMIHRAILGSIERMVAILTENCAGKWPFWLSPRQAMIIVVHKSVSDYASKVFRRIFDAGFEVEFDEDSPDTLNKRIRNAQLAQFNFILVIGQQEKNNGTVNVRTRDNQVRGEIAVEALIHKFKQFRDTFAQDTESAETFEDSKEPPQKENVVDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFT2</accession>
    <name>A0A914HFT2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFT2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16972.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16972.t1"/>
        <property type="gene ID" value="Gr19_v10_g16972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8206" evidence="1">
        <location>
            <begin position="679"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16972.t1"/>
        </source>
    </evidence>
    <sequence length="1015" mass="114016" checksum="83F897E0C02E331A" modified="2023-02-22" version="1">MAPHGGEKRVARVEIHQTNMATKTLKHLFYDCDETVGQMVEELLTDELDMSMDQLTKQFELSVQLKDPDLGPDVFADMSKKRWKNETIENGGHYKVLLRNGGTNSSSSNVHPQQVNLLELSRQLESKGIRYIDRDNRQLLNDALTADQQKDCFVLLYSQSTLADEETMDKLSLCLEYLLELVGRGKECIFVTLGAQLLGEGDQNEDELPEAIRAIDGFPHIGVRIVKMNGDQLLTADYVSEEIKKLGLCTARIENSQLTDGTEPATGQTLLNCALPCPLSTALEGKCPNGDFLWGCDDCGKALAFVKQANAPIDHLFCACGRTPVEAFSFRCANVEEHGDIFCHFASKTVLTDQLVRLHKKEDLNILLMGETGIGKSTMINALLNYLKYPTMHEAIEADTVDFMIPARFNKTEHTATGRVEGKSVFLGEANAKERLDATKSRTQCATPYILPLKEGNKLCCVDSPGIGDTGGILNDQINFPNMMYSINGLEKLHGIGIVLKPDTNRASVNFKYCFNGISPICTKVRYRGSDFDVANVLSLLEEELKPLEQKYGVELLHRNKFYCVDNETFEKLCLIKKSGKEYSKKDMENYAESWAKSEAECHRLLDYLSELPPHLTRESVSLTDARRIVTDLAQPMANIMSRIQMNLVDINKLDSAIGKGEKEKDEVLKYYSVEDVRLEYPRTVCTDAECTTVKRTSDGDSTIVFTQICHDRCGLDGVVERQHPNPTLKNCYAMDSNNNCEECRHSWDKHMHLRCEQRVAKRSVDQSLLRQISQNRGSLSNKQVMQRQFEKEKETLCVNAAILNSLSSFGVKADNDNTEAYLNMSIKQAEKLVAESKGRSDFEGNRRKLEAQQELLQFYKVMKNQKSVSGGAQITPNDVTKIVGELCALPLFGKDIKQMYDAHQLAQQKQQERFKDEMVYGGKNQKAKPSRNRYESNQQKAATFDYCKQKIAKGKNWVSGTLFGTTQQQSNAQTYGDCFSNSSDGPLARVLHGLSTTDKDEMRCSTSIVKTCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFW3</accession>
    <name>A0A914HFW3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFW3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17.t2"/>
        <property type="gene ID" value="Gr19_v10_g17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17.t2"/>
        </source>
    </evidence>
    <sequence length="71" mass="8260" checksum="2378BB081C49CA79" modified="2023-02-22" version="1">MVDSSCPDHPPNSDTIIPFFWHILNSNHHDGKQHNVIYRDQEKLKLIKRQEKTGQQQAPLEGNCRPLSQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGV0</accession>
    <name>A0A914HGV0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17051.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17051.t1"/>
        <property type="gene ID" value="Gr19_v10_g17051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF6">
        <property type="entry name" value="NCS1 FAMILY NUCLEOBASE:CATION SYMPORTER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037067476" evidence="8">
        <location>
            <begin position="18"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="797"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17051.t1"/>
        </source>
    </evidence>
    <sequence length="833" mass="91810" checksum="C1098D4C64149713" modified="2023-02-22" version="1">MFYCIIFFVFINAKTFGAQNDVKLKDSSKQLLTFSPIVTELAQKIVEECLDEYKKMVKTRPYINSISSPKVNNPAIGNGQEMFKYLWVAFHAILRKLPNVRRHKRDHFLRFCQKQMKFGRHQFEAVDKIWARKMLIALADNCKSYIFDVSESHANRNAFQMSVTTLRNVQLQPPNSSRNQTEIDETCAILYEQYPGKNLCMFAKKLAYLSAFNRNVSIPASAVGCWPLNRNRNKAVKVCAQIMKARYEGELLRMTKYYSNAETKKQFLGEFAFDRQARDVESAIERMFGCQPQTSGCQVPTPNVGVPSANPEHRGAKCQPRTSGCQVPTPNIGVPSANPERRVPSANPECRGAKCQPRTSGCQVPTPNVGVPSANPERRGDKCQPRMSGCQVPTPNVGPVEEQTWNAYNIAALWMSIIHSVAGYLTAGTLFSLRLTSWQVFVALILSVLVVLVLCNFGSKPSQVHKIPNPVLCRVVFGVYGANIPSIIRMIICVAYFGVQTFLGSKAFALVILKIWPKLAALNDVQSHGFAGLSLLGWFAFVLLWSVQIALFRAGLSTARLVVDFAGPAVYVVMVALAVHLVATAGWANLNLNLSLGEEPLRLSESILTMFSAMALIISAMGSAIFSFSNFSRFAKSWNAVKVGNFLGLPVNYLLFATLTVVTISATKPVFGQLITDPIEMIAHIDSPGAVIVGGLTLTIASIGINIANFVCPACDLSNLAPKYISWHNGGLLAAFVALLLTPWNWYDQPAAIRYTLGLVEALMGPLYGIVMAGYYIALVPAMLARPNLDIQWVADFSWFVGCAIGFCAFAAMERINPKMKLAKSIGQDEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLN5</accession>
    <name>A0A914HLN5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLN5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2278.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2278.t2"/>
        <property type="gene ID" value="Gr19_v10_g2278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2278.t2"/>
        </source>
    </evidence>
    <sequence length="546" mass="62936" checksum="2CF4B3E771F2DF4C" modified="2023-02-22" version="1">MLGSYFFNMWPPDDIGKRQESGTMAPCRENSNATKNSGRRTTDDIDYRRFVHMDFSYTNSSECDSASVVPEYWYYAITRHVFFEDGPCEVFRVNVRERMRSPERIGHVQLGGMIGTDRLWLDRSCANFYGICIYPGLAEDGTVTREGASKRCFRGDLAFGPEDGPVRLLRLIRHNNTLQRMDMALAGGVFGGVENPNLTSICWLRPSLLLMKTRDLRSTIDDRTTQDWRMGFVRFRVSLALPLHFNDVTLRMLLCTHVYHLRIDTGRSIAFATKIDFPVPIEQPDNLRVHPASCPVAQSDQIFVYLMEEDSATNNDKHQKQKMLPLFYRVDMQHRCHFYNDANSSWERWDDYSSADSSIPPGKYYFQRDRFDKGLLLLNYLENCYVELHIRPLERRCTFKRFFRAQRSFWPDREGIVFGKTTPDDRLFLLYRSPPVIWPLKLLSFWKLTALLDQNGATGFNNMTINSNEEAQQLFVVNANVCKVWFVCGVYATLVRCAIVLGVQAGGQVKENPVFPVFAIFTALCAKFASKQGEVTEHDPKQSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLQ9</accession>
    <name>A0A914HLQ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Caspase family p20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLQ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2297.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2297.t1"/>
        <property type="gene ID" value="Gr19_v10_g2297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1470">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056586">
        <property type="entry name" value="EF-hand_PLCG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23329">
        <property type="entry name" value="EF_HAND_1_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="7">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="6">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2297.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39350" checksum="E0D2239F7F8A69BF" modified="2023-02-22" version="1">MPMQIGSRCVLSFVSKTGDANGPSSTLVGLFMPNGWLSNAGRTTSAAMPSSKCAKSPFCVPNCKCWTCDSSKRLSEHEGGLPIVVPWFAQKAFCPPPHPTSAASVSIKHTKPFVQQRLQCKTSSKQLQEIIEVYSNSSSPRGLALIIANDKFTNRRLPARPGSDVDVKNIKKLLAGLGYDIFANRNETAECSKNCGRGFRRRKVRCLAARNNSVRLDKGKCTEQNRPRRREPCFVRNCLPSDCAELREQNAHTTGMLDGNYTLCTILARHRGQAQARIFSVDFMVAHSSFPRYISWRCTAHGSWFIQAICKGFSEMAAQTDLLTMMTEVNALVQRLECHEDKGKNRRRKRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLW9</accession>
    <name>A0A914HLW9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLW9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1994.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1994.t1"/>
        <property type="gene ID" value="Gr19_v10_g1994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
            <begin position="315"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
            <begin position="385"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1994.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47968" checksum="02E901A244C55448" modified="2023-02-22" version="1">MCRCRRRQVQAVSAHSPRPASMLPKAARSAPAQPVAIVNGRPIREMYCAIAGASRYTGGQDCDYCEAGTASAHPASNLVDGTPNWYQSPPLSRGMAYSEVNITIDLEQEFQIVSMFIQMANSPKPGAWFLERSADFGKTYQTWQYFATTAAECLRLFGIRSLLPIIKDDDVFCSSDFGRLVPTKNAEMSISLVEGRPSKNNVGGSPMLKQFIKATNVRLRLLRPSHLMDLYSNRDRDATLQYYYGIKELHLLGRCICNGHSANCEAAHDPSRPRARLCLCEHNTEGDQCERCKSGYVQKKWRASHDTDPFVCEPCNCHGHSGECVYEQELDMNNASLDIHGKSLGGGRCLNCQHNTQGINCNQCTPGFYRPTCKQWTDLDVCQPCRCDPTKHTGNCAEESGNCECLAQFTGPNCDQCAAGYYHPPECRPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM61</accession>
    <name>A0A914HM61_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM61"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g263.t1">
        <property type="protein sequence ID" value="Gr19_v10_g263.t1"/>
        <property type="gene ID" value="Gr19_v10_g263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003134">
        <property type="entry name" value="Hs1_Cortactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF23">
        <property type="entry name" value="CORTACTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02218">
        <property type="entry name" value="HS1_rep"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51090">
        <property type="entry name" value="CORTACTIN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="611"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g263.t1"/>
        </source>
    </evidence>
    <sequence length="671" mass="74627" checksum="1A49DC8111D05258" modified="2023-02-22" version="1">MSLGVKPAPPLKPAQEDEDDWETDPDFLNNVSEKEDVLKSDQIEKERKFALMPKPSDGYGGKFGVQHDRVDQCAVGFDYQGKVEGHASQRDYSHGFGGAFGVQTDRVDKSALGWDSRETLQKHESQKDYKMGFGGQFGIQSDRKDKSAAGWDEREQVAKHESQTDYKKGFGGQFGVQSDRRDKSALGWEEVEKVKPHESQTDYKKGFGGQFGVQSDRKDKSALGWDECEKLQSHESQTDYKKGFGGQFGVQSDRRDKSALGWEEHEKVEKHESQTDYKKGFGGQFGVQSGRQDKSALGWEEKQREVGGGRQAIEVPKPTEEAAQSQSKSDGVETCKGAAKSLRSKFEQMAMQGDQQNLDRARGERERRKREDEQLRLRQEAEERQRQQRLDEQWAKQSEDGVNEEGGQSVQQQQPRQRPSIGVRLPYATSAATSLEQQQQQRRSTADDHSTESETAAAAVEAEPHPPPVKVLPTVAESPQLKALTVPMGSVGGIIRAVQRISAVLEKAEEEEEEGRLGESAEWADETADPTQEVGEYGERQQQFKHVTSQHQYELPPIVADDVENDGITVAVAAAHSSEEADQNVPPSDPTPMAAAAASVEGTALPITSAAVGMTAIALFEYERQDDDEIGFEVNDLITDIEQIDVGWWRGVCKGRYGLFPANYVQLTERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN54</accession>
    <name>A0A914HN54_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HN54"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g214.t1">
        <property type="protein sequence ID" value="Gr19_v10_g214.t1"/>
        <property type="gene ID" value="Gr19_v10_g214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g214.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23441" checksum="3C3CA5D174B8C5F8" modified="2023-02-22" version="1">MPLIVPSDLLNGLLYLASHFLCLELFRSTLIPFLCRVDAISLKVRLENGHLHADEVVEVLDFLFRHPFRLSLFLANVFYRAGYVLSYVQCMALCELLLNAVKENGGDPLLLHQLLVLLCLVFLLYLHLITILNILDMFDQLQFALFSFLRFLFTTDRKARRVFAFLKLDGMTLLRLMGAGDLLDTDFLWRPKEHQEDGAVHGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPC3</accession>
    <name>A0A914HPC3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPC3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2653.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2653.t2"/>
        <property type="gene ID" value="Gr19_v10_g2653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2653.t2"/>
        </source>
    </evidence>
    <sequence length="211" mass="24576" checksum="F863B23998D0BAEF" modified="2023-02-22" version="1">MQNGQLNEQSVGENAKNEIQILSTYNENPTEEVKVRVINRIANLPRHAYVVVGNYEYDFLLGGARRRKFRHDINVKLANSNKKKVQSFKQKKLFVPSKKAEEVFFEMTKRFWHAQSFSESNANCLDFVFNFVCALFDGNCPKKKLWPNNFVELDADMPDEYAKLDKLRFPASVFERQPISLPVVKDPICKMKDHQLEFRIKNFECNSNDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR11</accession>
    <name>A0A914HR11_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3851.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3851.t1"/>
        <property type="gene ID" value="Gr19_v10_g3851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3851.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="12871" checksum="E76ED4D5FD5FBFD4" modified="2023-02-22" version="1">MVPVLANHGTGTGIPGANPDHGAQITFEKIWHFCGNNWKSPSAEPFDVGDVVGCGVDLATRQFICTKNGVLLDTADLIVSSAADALPIVAWDSDGEATGGKIEATGGKIEANFGPNFKYKAIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSP1</accession>
    <name>A0A914HSP1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSP1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4284.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4284.t2"/>
        <property type="gene ID" value="Gr19_v10_g4284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4284.t2"/>
        </source>
    </evidence>
    <sequence length="239" mass="25869" checksum="9DCFCA2C18C763C6" modified="2023-02-22" version="1">MSANRGRGRAASAAYHQQVAEPPVRGSGRGGYGRGMDVQQRQQEATPSPSLRGARGGRGVGGHRDEHQPPATSLATPLSAVNPSVVDPLPVARGHRPPMSRYGAYVAFTKQREELEQKPVGPTEKDEPKHPLLDKVVLRMQEHKKAEEESTNSQIQEVVVTSSQHDGGHEQQGGAVVVAVSRESNCRECLFRAEFVHLMRSIGHLLTEFGNAIGGGRNIEQNHHGNAIADGHNNEQNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTR6</accession>
    <name>A0A914HTR6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rubicon Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTR6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g389.t1">
        <property type="protein sequence ID" value="Gr19_v10_g389.t1"/>
        <property type="gene ID" value="Gr19_v10_g389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="6">
        <location>
            <begin position="164"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g389.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39707" checksum="20BFCAF1D499CA4B" modified="2023-02-22" version="1">MTSHLVRQEALLRSEFEHFINSQIATLIAEQRAKNVELTRENELQIAIDFCKNFLLDANEKNIGDGDGVQRRGETQDWDGTGGGEHEKHRVEVLAKLVELRLELEQHKERISCVELCPSLVISRTDYSLQFQLCPEKSLLYQNYQCAECCSPIGYDDDCEKFARVCDYTGLFYCRRCHWNDEMVVPARIVRNWDFEKRPVCRATKQLLTTVTKRPLINLEKENPTLFKFVQKLDKMQKMRNNIMLMKCYFVSCKVARKLRILQHLNRCQHFVENDAVYTIDDLLQLANGRLLVDIEAIVRIFTAHITEECEICRGNAFFCELCSDTERIYPLPPPMLRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU81</accession>
    <name>A0A914HU81_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU81"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4714.t3">
        <property type="protein sequence ID" value="Gr19_v10_g4714.t3"/>
        <property type="gene ID" value="Gr19_v10_g4714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4714.t3"/>
        </source>
    </evidence>
    <sequence length="703" mass="79216" checksum="1A732BD3E7229B46" modified="2023-02-22" version="1">MSWVGDELVVMSWVVMSWVVMSWLEKSRNSRLNRRRSLQAKTAVIELEQYQKLGEHSADKGHRVGTKPAQIGTTHRRDFRNCPSNLFLLASLCSTSRGWHLSFCSPHANSVFSPSDNGVGVALNDQLQHEFICEEDFSLNYAERLHDIEEGAQALGLIVRTSDVYAVIWSAKHDLVRIQLASGLLNSRGLLPREPLSLLAGAELLQNGQTLKVLPYFGRHNSRRVNQIDEQMHMLNVGARFKVVNVLGVAIRFENIATAGHLGIEAQTDIIRMPAKKTAKKTRKLDAEDVRKDAVVRINSPPVPTDQKAGRHDAGSSTSLHALLFDGIYVSDDGEMKFVVRHEDEIRSLTYKEVKETDPRGLCDYLIGKVKFVKRKDDLPLASLAIPLGEQRQQILKQIADEFGLRFNAFFFNQIEQCFFSLIGNVDVSLTLTIDATLLTAKIACHAARHLFFAGPPIQPEVTFLWPLTDWNQFLWSVRGIFSKFFVGLRCDRTTKHLAINGARPMEESPAIPVIEQPEDDDNDGERGSGGHNEDSSRFSVAAVPHRDLPLEKIANDLMLRLVRVPGKRIKFLPYEQHRTKKNDNFLYFEDLNLSPDGRAWIRVVQGNNCKDNEEIKKEQWLKINRELLTYAIMGKCSLNCQTEQQHQQHHGSGGGVQITKAYSSSIILIQRANQSVSHGQNHNDSNFHQQISSTTDGPILSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUH4</accession>
    <name>A0A914HUH4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUH4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g388.t1">
        <property type="protein sequence ID" value="Gr19_v10_g388.t1"/>
        <property type="gene ID" value="Gr19_v10_g388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g388.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9495" checksum="F50D8A34B705C463" modified="2023-02-22" version="1">MRKGENDIISNGSDVQSRVGRAETSSRRCGDGAEAASFLVRSASLLAFQAVGRPMNAADFRVFTPLHSFLLLLAIFFQNNFSPHFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUT5</accession>
    <name>A0A914HUT5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUT5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3974.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3974.t1"/>
        <property type="gene ID" value="Gr19_v10_g3974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036849065" evidence="2">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3974.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28606" checksum="403D66A87C5FE14E" modified="2023-02-22" version="1">MEKFRFFILLAFYATNSLDKAESVQLEELEELPLQTFDELFVDEWWDKDEAEGLKTPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQNPTLTESDHSDYAKNGEDQNEITSNAEDERKRKIVDEFHAMKDGKKKMDRKNLVEKFDQMKAELNRDGFKNSYYQEIDKTVAKELGLSLRTIFNWKRELGQTEPSKYLHSEQTELMKRYYEIKGTNPKISDKEIAKMLKIGRVTLVRWKKQFERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUZ9</accession>
    <name>A0A914HUZ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUZ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4417.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4417.t1"/>
        <property type="gene ID" value="Gr19_v10_g4417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4417.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31702" checksum="1EEB6C3CCEAE516A" modified="2023-02-22" version="1">MCRNSMDDQVNEHFTYASVSGGNGVVGSSFEEHWGHICFASSFAVAIPLTMLLPPPIDWVVFHTPCSNLTVLDEMNYQILKAMFDRLLNTNRFWLGVVCCADVYPDCKAFMDQVKDYFTYISQNAVRMLVGGTDPNVNGMITFNQLPPELLFEFVHCFRAEHDVLNAVFSSSQTLRNYLLPRVVKWQAVRISKYIGLKTMHERLVSNECWGFVLGAAAFDPDCKAFMDRLKDYLEDSAILIQKAVCVPVVEFGDLSNGCATAGPHFKPTTKKFARRKVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW21</accession>
    <name>A0A914HW21_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HW21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5196.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5196.t1"/>
        <property type="gene ID" value="Gr19_v10_g5196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5196.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19717" checksum="19179827BB594E2D" modified="2023-02-22" version="1">MDDLSRRKIRNTSDGFNGWEQWEDGGRAEDVASFRPNQLISCCCCGRTQQRWERGEEPIQAKRIHPAGGGEESTNDGREANEMMPHSSPSAELRTVNADVNTVLFNDGNLQLTQSIHQDGPKPVADTNGRRQLRVAPMPTVKRPHNSSTLLNNDIDQMLLAVLRGEGGGVDRVIAQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWT2</accession>
    <name>A0A914HWT2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor AP-2 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWT2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4742.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4742.t1"/>
        <property type="gene ID" value="Gr19_v10_g4742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="356"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4742.t1"/>
        </source>
    </evidence>
    <sequence length="626" mass="69144" checksum="7CDBA8372EEB9D04" modified="2023-02-22" version="1">MYHNHLGEAVQQHMTTQPQQQIVGSKRPLSEESDNSENINVQTAPKRFHPMDPKSGDSPTRESGEDGVEESADEEEEDESNGSSDAEATHQPINSATNFGYTAGPPVHAMANPSMLSMGSSAMAQPPYQFQNMAQNFFGRAVTSQHQQFPPFDFPNAYQMRPFIDKKAIANADQSTILRNLQNFYYPSLFSSPHGSHLQHQQQPHNYGPVQAKSMEGAPNSQMMAQRPLISFGPISSAHPTQYVASPSSFALQHLSGNGIRANALTTHVPQGTPPVERSDNSINNDSGLGLTDRSGKDSKNESSSTDDTANFVREEFGTQQNSTANKFVQFVPFVRSVSIDGVQQYCDLEQIVYSETPARLTLLGNMTKYPITLAEIVRRVSPPECLNTSFLSGILRRAKNKDGGKRFRMELQRFNCGVDLQTGRRKTGAITTFTALCERESIQLAKDFDKLVKDEQNGFPDKELATELIRKAALNSLKEPNCTQLLGNFQNASNILRDAIQLLEGAIEQETGELVSPVTAADLVIQQQQQQANAIDGDGVELMNRFKRFARLSHCFGNRGMLCAWQILLSVFTNCESDLQRMSNSNYPSVELKQRKQPTMALPAEFTAADLSTIQAQGSSSWMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX41</accession>
    <name>A0A914HX41_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX41"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5283.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5283.t1"/>
        <property type="gene ID" value="Gr19_v10_g5283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5283.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23525" checksum="C00CD06AE4DDEBA0" modified="2023-02-22" version="1">MFYACLSILVLLLVIFCCVCLSIIDLDTYNFGLYIVLLCIVGTMLACALCVANPNACPNPVWYSNFCLMLQEMYPSPTQFDKAAHSSPEMNGIRSRMMAMQVGVAPNGQNQSASGGSGLHLRHESRATVAMLAPAVHIMHQVWRGMAWVADGIDEEEEATKSYDHAEQGTSRSCSQEGTDSVQKRLSTIAESSSSAPEEVSSEFASGNDIMIKRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXG7</accession>
    <name>A0A914HXG7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXG7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g469.t1">
        <property type="protein sequence ID" value="Gr19_v10_g469.t1"/>
        <property type="gene ID" value="Gr19_v10_g469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g469.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17392" checksum="EC089F0F5E45891E" modified="2023-02-22" version="1">MQQMKKQPHNLGNFRSAHLEISSILSIDGMMLKACHNIELMEVGYAFPDFTTTGTPEGSILNELRYATRPANFIICIYNMGAEFLEPNIDGTSNAEFLMLNFQTAEKLVFERCNEDYWQLVRCPMSRDESDWDELENKQLSGSRRVKRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXK4</accession>
    <name>A0A914HXK4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXK4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4713.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4713.t1"/>
        <property type="gene ID" value="Gr19_v10_g4713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4713.t1"/>
        </source>
    </evidence>
    <sequence length="511" mass="59203" checksum="6837239C9CB1F48A" modified="2023-02-22" version="1">MTNNVKKLGICVGSGRTGGDRMVPLSARPTRLFTLIWNQTEGLVALLGQKMKRGTWVLFTLSTQTVHVHFVDRRMVNNVSKTIETVKLIGECAFYVLSFVRSFQRYNDYFRIGMDELLGWVLVSEDCFVRKLILHEDVQAQLVSIYREDCVRGFNWVAIAVNERLQVGSDCYRKIDGLPRFLDAIASEYYICREKQFAARRQLRNPLPSMFISEHGHNPTIKTMLSNEYALGLRYAFEMDYERDINAAEMLLTCLVVFKCDRAALVYNKEQRIGVVRSCDFDSHEAFEAVCQLGNWVVGKFTRPFLAMQLQLEYNLMLALRHGLRAVQPPNGLATQTRHFREITRTHPQAKYFRDKIEDERHTYKTVMVNVPVHFTSQNVRKVRRRRCNGSAGMLVKTVWGNVFIDTIVYSYDNFEGRHLALWVSCLPQRITSLSHHNCFCNRMPKWSIKEEGMGSGELGQKKEQKALAPKLKRRRREGKICNAILLRQLWNSTGKRIFVSCLRIDVFSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXM7</accession>
    <name>A0A914HXM7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HXM7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5609.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5609.t1"/>
        <property type="gene ID" value="Gr19_v10_g5609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ZnMc_astacin_like"/>
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    </dbReference>
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        <property type="entry name" value="Peptidase_M12A"/>
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    </dbReference>
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        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-38"/>
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    </dbReference>
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        <property type="entry name" value="ZnMc"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
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            <begin position="24"/>
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        </location>
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            <begin position="397"/>
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        <location>
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        <ligand>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="516" mass="57610" checksum="68893141CBB8F04D" modified="2023-02-22" version="1">MRVSMSPIILLLFFFIVAFLSNCSVQERTRKASKGTLEQIKQLFNEKAAHRAFVQNDPRLLADEPHGLGGLRRNPAARRHHNELAVNDPDGDYLQGDMELAEWQAERLRHKLNASAVKGALKWRRRRKKRKIGRVQWVVPWRWDRRRPISYDMAENVPEKTRQKIRHALAIWQNATCLRFREGGSADVDRLEFFDGGGCSSFVGRAGGTQGISITTPGCDFVGIIAHEVGHALGTFHEQARPDQPRHIAVHYSNIPAVRWNNFQPIGDDQAATFGLPYDAGQFRSDRLGEGTPMDIGIMLAIFQKGFEHFSGSVMHYGPYGFAADHFRPTISTLDSHWFFTIGQREGPSFLDIDAINRAYGCADHCPRKLNCQHGGYTDPNDCERCVCPTGVSGTLCTEVQPSSCGAVSSTAQNISSPEFPNNFPAASGCVWLFRSPPQGHVLVEFVEEPFDYPCEDTCDKAFVELKTGPDFRVTGYRFCCSTPPSMAFRSGTRVERSAMAEDGGKCEGKSNHHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ10</accession>
    <name>A0A914HZ10_GLORO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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            <taxon>Eukaryota</taxon>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="Gr19_v10_g5791"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5791.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21877" checksum="5D4D6D97DCF321B0" modified="2023-02-22" version="1">MEYILANDWMNISNKNNNNNKENIPPAKKDGEEEISWLRTCDEEQEKEIVSEEVKEQEKTEVLPTTRCTCGSGRRAPQSLIDYLCKQYNCSIQELHVLLQNLEHRRAIVEHLRSNFQLRTNHLRPPVRNFGVRCSDLSVLGAHLAPAYRGYLGITVRMHYHVKHGMRLRQANLPVSLSKEEAITKHFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZF2</accession>
    <name>A0A914HZF2_GLORO</name>
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        <submittedName>
            <fullName evidence="3">Cold-shock (CSD) domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZF2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g590.t2">
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        <property type="gene ID" value="Gr19_v10_g590"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g590.t2"/>
        </source>
    </evidence>
    <sequence length="68" mass="7451" checksum="E48E23B10E5F685B" modified="2023-02-22" version="1">MGSSNVMTPMRTFSSTAPSSSVSPCTRENATRCSANSRRFVEFDVVRVRRGLETHCVSGLGGRPIIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZU3</accession>
    <name>A0A914HZU3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="11">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZU3"/>
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        <property type="protein sequence ID" value="Gr19_v10_g6184.t2"/>
        <property type="gene ID" value="Gr19_v10_g6184"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037985058" evidence="13">
        <location>
            <begin position="24"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="37"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="318"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="378"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6184.t2"/>
        </source>
    </evidence>
    <sequence length="438" mass="49052" checksum="9F7F80AE5C6C27CF" modified="2023-02-22" version="1">MQHFYSSLFFIAFAPLHILKINGQENAEMINPAVWSSSQHDLIVHLRANSYNITAFVPNHPGGPAVLQSVNGQDIEDYIEGRKCALGVCHHHRYAYQVLSQFEMPSDVIVGVNGKWYNITAFLPNHPGGPFVLKAVNGQQNVEEYLEGRKCVFGVCHRHSHAYEVLSQLEMSSINTAAQLPSPQPQQNSSNSSSVPYPLGRSKSNSQPQKFAPLAKQNVTERSNNSDSDKKETIELRNNRPEFGLSNNPSHHQKKVEKEEQIEKKLQRDKKFKQKSEGNVPKSKNVPADQKQAGIGNKKPNADIKKPTHSSIYANVTAQNATKSQQQKRSNDNKNVTNSDRQLAENGQTNGHDNRQKGTKTPQQLVEPFVIFLERISNRKTKSNSPAAPDNHSAHRPLMRSPRGHRGGAGEGRRRRVPPPLCLFVKRSEQPPHDYKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I038</accession>
    <name>A0A914I038_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="29">Notch</fullName>
        </submittedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g5632.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5632.t1"/>
        <property type="gene ID" value="Gr19_v10_g5632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022611">
        <property type="term" value="P:dormancy process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.320:FF:000001">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000053">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035993">
        <property type="entry name" value="Notch-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01452">
        <property type="entry name" value="LNOTCHREPEAT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90193">
        <property type="entry name" value="Notch domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="18" id="KW-0010">Activator</keyword>
    <keyword evidence="15 22" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 23" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="19" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="255"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="386"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="27">
        <location>
            <begin position="441"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="27">
        <location>
            <begin position="482"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="1074"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="1171"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="1204"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="900"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1283"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="908"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1283"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1308"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1334"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="1353"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1369"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1383"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5632.t1"/>
        </source>
    </evidence>
    <sequence length="1615" mass="178939" checksum="7A148BD0C79639F5" modified="2023-02-22" version="1">MDGIARYDCHCAPERIGRLCDPFNESFTCICDDGWKGQNCTEDVDECSDGLTQQCFNKGKCVNLVGSYKCECAFGYTGKMCSSRISYCTDQPCQNGGICYDYFGRYECLCNFGFSGKNCELQIEEDVNNCRLDCQNGATCQNAFSKQCECPSKFSGRLCEIEKPDPCEFHPCNEEQICTPTINYDSFTCQCPPSLAGEHCEHRLAPCEGGNSPCVHGQCLINASLDERQTWHCECQSGWKGPFCNLSAETAQNSFNQSCPLHTNPCQNGGQCVNNVNNVKEHPNGGAIFECICPKGFTGQLCENVPIERHCENGCQKGGKCAKLKDASWGCICLVGFEGAQCEIERNPCSKNPSPCKHKSKCVNLGDDRHRCECAPGWFGVNCEQNRNDCENIVCDNGGKCHDKVNNFWCECSRGFTGRHCETSVPVDKFNRTDLVDKTNCAKVGCEAKYGDHRCDPECNLFACQFDGGDCSTKQAQPFGRCPQASYCAHSFADGKCDDICNNERCLFDGFDCLERPQSKCPWMDECARVYADGHCDEQCNQANCGWDGGDCVHDAHEPDPADDQSKLLLGELFLVIAVHPSTLINEPTLLRQFLVTLSAHLRASLALSIDQYDQKPKLFEWRSDKGIGQRIELPAELNATSLFSVRYEAQSEAETHNNRSKRGAEGEGFVEGIALYLQVDVTMCNMISPSSLAHPNNRMVGVHTLCFSDMENVAAYVGAANAKKSFNDIPATILQSEARKPSTSRLHFWLALLAFAMVAIASAAVGTVFASARIRNRQRRHAKTWKPEIYDSKPTKNGLATMCGGGHHPPLIVSNAHPFNPYAQHNHHNGHQHQQQQLMYNASNGMESCASSTAASAIPLIRHVDSLNSLTSIVHTNNQQQQQQHGQFHQQIHHYAPNHYNNKSLASHNNQQQQQQTMQSNSLHQTTQYCSSSSSSGIGGSSTEHSPIDTHCSMIEDVESRKLLAELRESALFSRYGLLGQEERLEPYLVNAPNERGRILLHLLFENPYFKEDDAEQCLLKNIQLLFTKGAKINALDLNDTSALLLAVRTQNVLAVRKLVTEFEADQRLADVDGCTPLYAACECGHLAMAEFLIGEAAYNSINNSEGEKDALLQVFSALYRRKETPLMRCAIMPGEQWLRIAELLIEAVDSDRRADFVNQTGDAEFLGYSGKTALHWAAECNNRPVIELLVRHGANREATDQKGRTPLFLAVEQGQYQSTETLLRLHADRTKANSSDTKIIPELTERPGFGPIAELFKKYPEQQHHQHIGRPFCTVVHLQQQRPNSGVDGSSSVKIGTKRQRTSGIRRSDGTEDKSDIVHSEVAKKAALSIKSGEQLTPKQQNPPTAGTANVPPPPSGSVIISPPPSQNVLSPPNSEQSVYSTSSPSPNNTSSSSTNCNNAQQVHQHANACGQYLLQQQMLQHHQALLRHSVAFQQQKFLQEHHQHLHGQQPNWIWPNGDMATAIITPKQHQDQQLQMVPPTLAYPSPMVNQPHLMPSFSCGSTTMPSADHLNTTPLSSAVGFNAQQQLQYKQSQREQFTTQDAFNMSSPHFNKCQNDFLQSTENFRPFNTSEFAGLANFACGVDPLSTSLDNLEDLVPDQHLAMEEPSVGCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I063</accession>
    <name>A0A914I063_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I063"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5681.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5681.t1"/>
        <property type="gene ID" value="Gr19_v10_g5681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037225886" evidence="2">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5681.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17533" checksum="25A56173D993DA9B" modified="2023-02-22" version="1">MTFISILAQSFLIIFSVFVIAQVEPPQQISPETPIVLSTTSTSSLRPGCPLGEELRICSFCDGTCRFPLPFCGFFCSLIPRCYCQWGHLRNRRGQCIPSDRCFSNKAAESYCCGTNRCLHCAVGYSCNVSSGQPFCRPHWYGIGLMSYDDETLEQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0C0</accession>
    <name>A0A914I0C0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PIPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0C0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5713.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5713.t1"/>
        <property type="gene ID" value="Gr19_v10_g5713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052742">
        <property type="term" value="F:phosphatidylinositol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037298703" evidence="3">
        <location>
            <begin position="24"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="4">
        <location>
            <begin position="431"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5713.t1"/>
        </source>
    </evidence>
    <sequence length="867" mass="99468" checksum="D6FA1F26127C1490" modified="2023-02-22" version="1">MISLPKALILAFILKFIIQFVLADPKNQLGFAYTSVSNERNYGRVVDGNILQFIVIGDIGGEEYESTVADSTAVKGTVANSTAVKKHRTTESQKAVAKAMDELSQANALKANFLLNTGDNFYEGGVTFADVIPRFTENFEKVYHYKSLYVPWYTIAGNNDWKGPDGIRPQIETPEGKWTFPAQQYVVHYTFGKDVQVRIIMIDTTVLCGTRSSDFTNAKKHFTWLRKELREAKRRRVNFLFVVGHCPLHILDKQRGYPCAARVHALMRYYQVQAYFAGHEHNLKYVDLSNAGELGIDSIDTKFIVSGAGSRMENAINGSRFPGTYMQFMKFLYPMNVGEVLKVKGEKTRARGALDGGAFVGVEIDANIMLAKLNFYAAGMFYNKDGTKKPIENWHKFEGQEVQMKPRRTDKTDENFDICNEFLEVGPQLVDDDHFKLDETERIQNILGTYFFYAGEAFDGLRKKLGIGYQKLAESFLSGDLVFRIKTEDKSNHFILMNNVFENAKDVPLLTFDVKGVFSRQRAIVQSTKELLPDKMEAMFKNGILLDKAMHKNITERLKKDFEILAKNNVNDWSIIFGVHFVSNEEHKISDESPVDGILPYFNGRCNQCRTHPDPASPFLDDQTLRLYIGIVDFFTPFSEERQTRYIEGLQKFIKNVNSNHLMDYVKAGSVWETFGPIPPEMYGHRMLSFSMVCAFRWWQNDQTVDAPEAIRQALIQAFCDSYGKQLEKSEEESMLAMLDDKSKDWKNELQRGNYLFKHHTVTIFGVPLFKRLMEKWEKYFWNFLNQLAENKLQKENGTFVHENRAFVVRKLSKNDVKNVKTELGQCARQGQPKYYYYALLDLQKNGTKDAHEFYAVTSDKKAGNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I390</accession>
    <name>A0A914I390_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I390"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g647.t1">
        <property type="protein sequence ID" value="Gr19_v10_g647.t1"/>
        <property type="gene ID" value="Gr19_v10_g647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g647.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13166" checksum="F470578A19867979" modified="2023-02-22" version="1">MVTPITESLENADPQDSPVHLGGIFALMEAQQNEDMTFIQPNLDLSRTTSPNLDPRTQAIVQVAEYLAEQPQPFSTDPFLYWKTKESQGEWPLLCGVARKFMSAPCGSVESRRLPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3S8</accession>
    <name>A0A914I3S8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3S8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6557.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6557.t1"/>
        <property type="gene ID" value="Gr19_v10_g6557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036995932" evidence="1">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6557.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11278" checksum="36DC8EC5D339EE6E" modified="2023-02-22" version="1">MNVLPSFLLISLILPCFCSGLLRCKAGLYNTDGLSVFEIINCTERQEYCSAVSCVKGDLVTMIWGCKRHGDCPNGTYLLHDATCRCKLGARGVNLSNEKLGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3W1</accession>
    <name>A0A914I3W1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3W1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6360.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6360.t1"/>
        <property type="gene ID" value="Gr19_v10_g6360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037885088" evidence="5">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6360.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="24550" checksum="57A331780F7044E8" modified="2023-02-22" version="1">MNMLLLLVSAVILLVIVLAAPSSQTTTDDETDSSANSETDVIATNAQIQLVNQAKSSDPNERLAAVSRIGLLLWNGANSDELAIAEFVSIGVLPVLVNCLKSTDGKLLVQAARALKSIACRKALAVVEAGAEPLLVKLLKSPNLEVCKCTVDVLANISWRSNARESKIVEAGAVPLLVKLLQSPDMDLCESTAWTLKNIAAASDDLALAVAEAGALPPLVKLLQSENMELCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7M7</accession>
    <name>A0A914I7M7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-mannosidase</fullName>
            <ecNumber evidence="2">3.2.1.25</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914I7M7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8249.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8249.t1"/>
        <property type="gene ID" value="Gr19_v10_g8249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8249.t1"/>
        </source>
    </evidence>
    <sequence length="547" mass="63326" checksum="9542FDD07E4F7332" modified="2023-02-22" version="1">MDNQFVAKSVDVWADILPRQNVLRIEFESPVEEANFRAEKYKVFQGHKLPPECTPPVYNGECHVQFVRKMQASFGWDWGPSFPTVGIWRPIQLEYFDRLSIQSFSPMVNFEKDDFVISARLILVCAIVRRPIRVKLRLLELGMDKEFVPNTKKCPNWELDGLKMKVPAKSVLLWHPIGYGTQPMYTLEVKIMENDFELAFARKRIAFRTFELNGVPIFLKGTNWVPISLFPARDHSERRKFSLQSAVKANANVLRVWGGGFYEMDEFYEKADEIDFMFACSLYPTDSNFLQSVEAEIEEQAQARDYVKLYKTHIQTVAKALDPTRPLLLSSPSNGMETDREGGIARNPADPAYGDVHFYTESVNLWKAYNYPVPRCASEFGVQSMPLRGTMARWLDPSDWAYRSATLVKRQHHPGGVLNLPLLVFQHFNIPLMNNSSTTAFTSLHDILSAKVGMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMDMNNLGKEYLIMLKDSGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7V9</accession>
    <name>A0A914I7V9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7V9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7453.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7453.t1"/>
        <property type="gene ID" value="Gr19_v10_g7453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7453.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19769" checksum="7587FE14736D7416" modified="2023-02-22" version="1">MNLWEIDVNEFLRCGIDPNIVVAVQLLRTLSVEGASSPPVLSADGPFPSIFNDCSSPLLSRNVTEQQMFCIVRLAVSCCAFFHQFETISDTAADSLATIVVNKLDGMAKQLHTLADQQKRSGRRPTPAFKNPVHQVLECHALPSSVLLNFYKTRVVQPCQTIAEKYISSQKFEHFGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I984</accession>
    <name>A0A914I984_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I984"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g78.t1">
        <property type="protein sequence ID" value="Gr19_v10_g78.t1"/>
        <property type="gene ID" value="Gr19_v10_g78"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g78.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42349" checksum="6B2E47CE3CD36F94" modified="2023-02-22" version="1">MIQSDRLVELTNEYDSAKIFKRQNTEHTTTRPVGEAPLGRSSHRSARSGAPLLARLRVLAVGGVSHVRCAFQFFASRPYLLQLLSCLLRFHSMEVGDQIATSSAECVDLFLQFLLDQRSRQQNVKLAHHWTEFIFHCVQTSHKMRYQLGQEAIITVLRYDETTLNDVHCRFLCCFLKDVHGRAWLRESGGLDRILWRLATPDQCGEDLDLLRLQQIVVADLGSVLHDHALLLTINHPNFLPTAIAQINRFLEENSEKCKIVSDRHALNVVTVIPPMSEDFCEVEIVEKSVSRKRKNDEVTDFDLPLCKDFNTFCWPPLQSPAASPPSARRFAWSPSMSPSTSSAAYDQYMSSPSASPPSDNAQFQLDDYLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9C9</accession>
    <name>A0A914I9C9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9C9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g871.t1">
        <property type="protein sequence ID" value="Gr19_v10_g871.t1"/>
        <property type="gene ID" value="Gr19_v10_g871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g871.t1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52502" checksum="87E74472F3B2496A" modified="2023-02-22" version="1">MKGRVAAHQQRADGGAGTWGETAGRLSWPPYKNGVSSHSFSEELSSSMLSAADVLLSAVVAEQNIFRMANSIGKAISTKEMVISNEPTRKKALIGSARNRNFVCDDVLFDVFKFCGHFVLGLKVALISDRFDLLVDAHFNTKEWSLGFLEIRRATDGNGTEIVKLSDWRGKERHLPIPQIPLPNNVIGFEHIRISYYDQSVVEFLQSIRRLFDSNGTNLFAEIDEGQTRTWETIGQEIWPLISDNICGLVLDALDLFRLRQVSPNFLSNCANLRKIQSVNSVLEFPADGGAFASTGQALTEWLHTPRGDGLPKVLECSYCPIGMEGLKQAFLNAADPLSFIIIAWHRNSDDTVPFELFNKLTEERLVWRRFNNNYWLLIRCPIERDEDKWAKWETEAFVSFGLEWNFIAIEFNDSDIGDGQSPKKLPALTGQSSDCPDEAKVEDAFGAAEEPFDNGAFDQFDNGDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9H0</accession>
    <name>A0A914I9H0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9H0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8136.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8136.t1"/>
        <property type="gene ID" value="Gr19_v10_g8136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8136.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18051" checksum="38A7F14652000187" modified="2023-02-22" version="1">MPGKGRKCHSRNHFLHLHPFHNSFTCGSVFIFILFTIPSLVEVSSSSSFSQSLHLWKCLHLHPFHNPFTCGSVFIFIVFTIPSLVEVSSSSSFSQSLHLWKCLHLHPFHNPFTCGSVFIFIHPQILLIKTMPLDPRRLIVCSDHLIRRLFGAFRGNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9K2</accession>
    <name>A0A914I9K2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide-binding protein-like 3 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9K2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g876.t1">
        <property type="protein sequence ID" value="Gr19_v10_g876.t1"/>
        <property type="gene ID" value="Gr19_v10_g876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanine nucleotide-binding protein-like 3 N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g876.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31107" checksum="8F824DEB9256F6E7" modified="2023-02-22" version="1">MAKYCLKKPSKRLTCKKKFKIQRKVREHSRKLRKLSKESERKKKSDKPVSVPNKCPFKEELLMEAEQKRAELKTLETERKARQKSAKTNGKKVQQTKRKAKTDDASIEALAKRANNDEDDYNANRVLAEMLPEKTNNADADMLDARDPFGSRSDQIEKLVIESGKRLMLLLNKIDLVPRENLLKWLAHLRQQLPTIAFKASTQEQNQKLVGFSKCGQIQCDQQFEAAEVLPDGCLAGVDEVFDASDPFGSRSDTFNSLPPSSDKESAKPRLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9L3</accession>
    <name>A0A914I9L3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9L3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7966.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7966.t1"/>
        <property type="gene ID" value="Gr19_v10_g7966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7966.t1"/>
        </source>
    </evidence>
    <sequence length="594" mass="66709" checksum="AD04DA9248C12133" modified="2023-02-22" version="1">MVRVIFDGSNLRLDQFYQQTGSGPITYFEGLPTFQRGYGYFLGVPRQKGAGVGAVLRNLWRYLRPMISAAKPYAANIAAELGKEGLETGARVLNQVSKGGDIKDALLAEGKEGAKKLLDKASSSLQKGMVDVASAEVANAGLDFFTTPPTNCAVSNSSYREYLTLNPISSRPFHFKIHPITSYIDLSKVFVATEFKIKKIAEDGLPSNLGSSDSVGLIQMPGATFIRNLKVHINQREVYDSNQLYSYKVYLDTELSYPVAAKDAYFGVAGYFRDTDLSKANDKRRKPLAESKAYQTISKLSADIFNQDLYMISNVEIDIELALQSDDFMLHQEKDKDKFVLEIVDCRLIVKTVDLMDGLSLDIARKLDVEPARFGIRKSFMKSLFITGGRYDFSANLFTEEVPRRVIIGLVANQNYIGHKQKNPFFFNHHNVRDIELTASGRTYPQYPYNLDYKNNNYARAYHDAQEHLGLACTTESNGLSYSMFKTAFCLYVFQMTNSQEDSPGFELIKEGCTAGLQLLDFICSCERGEFGAKMDNRLIDKILFENVATRRFFMGTFPSDCLPECTRFPCSLIVNLSWQARLSLVRDLGQVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9M2</accession>
    <name>A0A914I9M2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9M2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8565.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8565.t1"/>
        <property type="gene ID" value="Gr19_v10_g8565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037963347" evidence="2">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8565.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14800" checksum="15303C3705D9E8F5" modified="2023-02-22" version="1">MFLLHRQMSLLLPLFALCFAAPPSNYGTSVKLEGISTEKNGLSVTYRTFNKTEKDDGFVFPNINDSEVARNDSASTNNATDVDHCSVLCKKGAFRTGCVLAVVFMLLVVILLLFVLDRLYRRDFKEHIYISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA21</accession>
    <name>A0A914IA21_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IA21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8892.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8892.t1"/>
        <property type="gene ID" value="Gr19_v10_g8892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037757787" description="40S ribosomal protein S7" evidence="5">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8892.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24174" checksum="FB250845A9CC637E" modified="2023-02-22" version="1">MSVHQNYAAIFLFELALMVATFEKLVKTDGKAPDDLEKQVATALSELGQNSEIKAQLSEVYFVGAQEYDFGNKKCILIWIPVPQLRDYQKIHPKLVRELEKKMSGCHIIFIAKRRILPKPQRGKNRKPLGQKRPRSRTLTAVHDAILSDIVFPAEVVGKRTRVKLDGKQIIKVHLDKAQQTTVEHKVDTFSHLYKRLTGKDVVFEFPEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAZ8</accession>
    <name>A0A914IAZ8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione synthetase</fullName>
            <shortName evidence="1">GSH-S</shortName>
            <ecNumber evidence="1">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1 3">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914IAZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9165.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9165.t1"/>
        <property type="gene ID" value="Gr19_v10_g9165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036880312" description="Glutathione synthetase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9165.t1"/>
        </source>
    </evidence>
    <sequence length="508" mass="57526" checksum="23011E1102989AF9" modified="2023-02-22" version="1">MANILLILFLFCFINFGNATPTTHNQDKTDKEQQYCVPNIEQDPQILLEQCLDAKDWALSNGLVKLVVVPTCPECRKKPGKKNVMTQFLPLSLYPSPFPRKLFQQAVDVQKAMLLLYFRASCDYAFLKEAHREVLNSEVKNGTKTFVTILDGMFSDGIRQSVTMFCQRADYMASENDDGQYVLKQVEVNTGAIGSFATSPRFSRIHRRMVSNAGIDASESVMPLDQSDTMVAETLYQAWLEFGNAEAHQLESISTEEIKCRFITLTEGDLNRLSLDPDNFSLILDNKYVVAVVFDRIGTNISKEESDLMKKTIDRSTAIKAPTLVIGLTHTKRMQQVFTRPGMVEKFFNNPEEAHMAEAIRQVQTKAWAIGEDKDVTEDIIKKATENPQRYVLKSNECRPVPEKIFFNENIPKKLATMAPADRDFFYLTEKLRPMVVKNHFIRPNMEPALNVDATPELGIFGCLIGNMETGKVSYFSRTGHMMKTKLASVDEGGVWKGYSVYDSPYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAZ9</accession>
    <name>A0A914IAZ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAZ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8298.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8298.t1"/>
        <property type="gene ID" value="Gr19_v10_g8298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8298.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="19144" checksum="5B5CAD0B97902665" modified="2023-02-22" version="1">MEERWKTGRMKEEDGRKMEERVDEWKKDGRKGGRKEEDGRKMEEREDEGGGWKKGRMKEEDGRKMEERVDEWKKDGRKGGRKEEDGRKMEEREDEGGGWKKGRMKEEDGRKMEERVDEWKKDGRKGGRKEEDGRKMEEREDEGGGWKKGRMKEEDGRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBB5</accession>
    <name>A0A914IBB5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914IBB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8628.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8628.t1"/>
        <property type="gene ID" value="Gr19_v10_g8628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="149"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8628.t1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44114" checksum="154AC515C558AF24" modified="2023-02-22" version="1">MGLLNSVFGPAEPKPKQSNGRKRRKRMSPAKVLAHQIAAKVIGEMSLCAFTDEQIINLMDAGIELFEEEPARVSLQAPCFIFGDLHGHLPYFLKFFSDGHVEPQLLKLLPPHYHLLFLGDYVDRGDFSLEVVALLVSLKVLFPNKVTLLRGNHEVEATNRRYTFYDEVEKKRPTGVDNIYQACNKLFMKLPLCAVISNTFLCMHGGLPRPEFWDVLMGDNFEKPKTDEDLDNSNLYLDLLWSDFTNNANKLRLDNRYKPDSDFQAKYGNYRFNQWCMAGIEANDDFVAEFLNRFPSIHGCLRAHRHEEKGHAMNKAGTIFTIFSAPNYCGNKQYSGSVLKLSADLKHAHFITLNPTPIEGTTSTSKSESDADSSTESSGSEEENDDDDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBD3</accession>
    <name>A0A914IBD3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBD3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g864.t1">
        <property type="protein sequence ID" value="Gr19_v10_g864.t1"/>
        <property type="gene ID" value="Gr19_v10_g864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g864.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16763" checksum="F4B6D9DD280A9AF2" modified="2023-02-22" version="1">MKEKREFIARMDEIKMSQHGEQNKLAKDLAISRNTFCCWKKEFGLPVNSKILYSESEKLELMKKYYKIKQGNLKIITLYKWKKQFDPILNKNSVDEHSLSENRATLADKDISEHPMPSSDDNLWAWNLANKKRTEKIEVNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBL2</accession>
    <name>A0A914IBL2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914IBL2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8430.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8430.t1"/>
        <property type="gene ID" value="Gr19_v10_g8430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037041615" description="procollagen-proline 4-dioxygenase" evidence="13">
        <location>
            <begin position="30"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="421"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8430.t1"/>
        </source>
    </evidence>
    <sequence length="764" mass="86619" checksum="4AC93AE997DC1510" modified="2023-02-22" version="1">MNASDTVAVLFLPLLLLLLLNVSVRIAFADVFTAMVDLENLLASEAATTSDLIEQYIEAERTRLDELSEFAEQYAKSLMDPQNRHHLSGHNEINESSVMNPVNAYLLIKRLTRDWKHIKQLMNTNQGDQFVKNITGVRVENAVKYPDEEDLDGAALGLLRLQDTYKLKTADLANGFVDGESVGNGLSAHDCFEIGRAAYNQKDYFYTLEWMQEALDRHPPVGLEAEIQEFLAYALYQQGNQKRALIATKRLVSLAPDHPRAAGNVKWYEERMTAEELASLELLPEVQNERVRQADIPERDAFERLCRGEFEMPPANASKLYCYLKKDKPFLQLAPHKVEIVHYEPLVVVFRNVISDAEIAIVKQLATPRLRRATVQNAKTGELEFASYRISKSAWLKGEEHTVIERINRRIHEMTNLDLESAEELQVANYGIGGHYDPHFDFARRGEKSPYKGRGNRIATVLFYMSQPKKGGLTVYTDLETGVAPTIHDALFWYNLHRDGEGDMRTRHAACPVLTGVKWVSNKWIHERGQEFIRPCPLKQGANEQFAVMHVCDVAAQWRKEFKKDAIIDLKIVSVLPIVSVLPVVIVPELFVATPLIVFTPKFLLRHPLAKSPIEDFLPGTSFRRAITEDGSASNNPSGVERLVFCSGKLYYEIVSERRNQCLEDKIAVVRVEQLSPFPYDVLMAECNKYTNAKVIWAQEEHKNMGAWAFVQPRFLSFLKQLGRGLTYAGRTPSASLATGNKYTHGRETAEVMEAVLKKPIEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBX9</accession>
    <name>A0A914IBX9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBX9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8784.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8784.t1"/>
        <property type="gene ID" value="Gr19_v10_g8784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8784.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="21989" checksum="1EA246F6187AFAAC" modified="2023-02-22" version="1">MKKLLERIWAKRPFRGLRRAASSSASSINCCSSVPCATSTTGHTYPYPRTHSTLMVIPSAVRPPIVSTGAGTIGSRNWASSVNTSGTTRPQSLLDSMDEQNNNNEQLLLHFPYHPNGGQPLLSNNNNNNNNEGEPWPTDGGVHVQQQQQQRQSLVSQYGFQTHRPRPPLNRAIPPIPESRSNESIQSGLVARQQSVGSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC44</accession>
    <name>A0A914IC44_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Glucosylceramidase</fullName>
            <ecNumber evidence="5 12">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:81447"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83264"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:34755"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:70815"/>
            <dbReference type="ChEBI" id="CHEBI:70846"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:34756"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="5 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914IC44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9461.t3">
        <property type="protein sequence ID" value="Gr19_v10_g9461.t3"/>
        <property type="gene ID" value="Gr19_v10_g9461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="14">
        <location>
            <begin position="126"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="15">
        <location>
            <begin position="476"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9461.t3"/>
        </source>
    </evidence>
    <sequence length="1108" mass="127806" checksum="869CEDAAF8DE08F6" modified="2023-02-22" version="1">MDKLSNLIYYFVFLFIFVVASGATSMFDCAERRFPGSESFVCVCNRTFCDLPIGPHRLSKNDDTAIVYMSDPAKYRLHQRKVPITLEAIDVEENRRKEKRRIVAANDEDGLLEIRVDATKKFQTVLGFGGAFTDAAGYNLNTLSSSTRATLLRAYFDKHIGIRYTLGRVVMGACDFSVREYSYCDTPDDFELKTFALPKEDLEWKIPHILAANSLSDGKLRLFSSPWSAPGWMKTNGRMVGASPIKGALDGPFYRAFANYFRRFFEEYKSRGINFWGLTLTNEPLHGANPGMDLNSTIQRRWANEVLAPVLKHSEASKNLTIMAHDDNRHLVLDAAKEIFSDYRTPNAIDGLAFHWYSPPEFSYDMLSEFHRQYPNKFLLSTEACTGAAERAEEKGPSMGNWTRALMYGHDIIEDMRSWSVGWVDWNICLDMQGGPNWVNNFVDAPIIINATADEFYKQPMFYALAHFSRFIPPNSVRIDAELEYGQSSNPKSVEFVAFRTPDNNRTVLVLISTANRTSKVKIRDGKRTIPVTIPPLGIATVEFYGTFVKCVSEIAYVRVVNNSPEACANLNPGFDYFKSVGKHIANEINKNFLCPEEPLPRAVVDQLLMLSFTFAMRIIISNNYNIYYWQIETLLSAYKILSTSNDDTNGVFPFQISQSAPFETLQASEFTTQQITRHTSEPNQYTENFKFLLKLSDHSLTTFEVYKLLETILIEVKGMDNESNVRALGEQPRALYTFVKQYFVENIDNKKSKFSLLKPNFWPSICLIGNGTDFIQTMRMLASTEQLEIRNIEFFQYANSQLVIISFFQFKTNISHKMVEINLPNWKVPNYMQNRIINELRRQALVQENFNFLSFIVDYPLTLYELLKIAKKIGEIELLEKDDKKLGEIELLKKDDNKLGEMKKNHEMLLNSSESKMFFEMLKYLKQSQEPIQKIKINSNEFCVLAFFVEDLLAELTTENKIPNVESIEVAIGQFILTKQQFCTENSIENDGNFDENLVNLSKAINIDVSLRDELQQIVPEIVEEIKQMLQNDNWNYYHLNYIKIVEWDLLEFNLHKIGKDQKWLEIKQLRDESQKAFSDWYSNNNAENKLNFEETMKNLIQILEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC56</accession>
    <name>A0A914IC56_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IC56"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9469.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9469.t1"/>
        <property type="gene ID" value="Gr19_v10_g9469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9469.t1"/>
        </source>
    </evidence>
    <sequence length="393" mass="46220" checksum="BB2AFAB2C68FB053" modified="2023-02-22" version="1">MIKKRNVGNPTRRRHRRLLSDPCAVCADSIQCYNFGAPSCQACTGFFRNSVRQKKIYKCRFQQQCYIEKGSRTSCRSCRFKKCMKVGMKKERVKKTKKSPQHFPNQEIVDFNQIRFLLRIEEILSKIRSSRTELSDEYIDQFASLKHLINSNENLLTRASEFSKLSPSPWEGEKAMELTEKFGFFVTRPKHRILDHLLCAGLIKSMPVTAALSSDDKTRFFHGIAIMICCFTSAYYSVQQRSDTVIKPNGLMPIWFFRVPRYAQDKKVTVFTERLYWHALKPFTQLGLDREEFVLLLAILLSHPCFATLSPSSQEQLYEECTKFSGILFRLLQRRHDTFSGVRRFVELFRLVGHAIWMANYYYKFATYMDVFHFKREREEAMPKAIYTIYSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICT3</accession>
    <name>A0A914ICT3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICT3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9651.t3">
        <property type="protein sequence ID" value="Gr19_v10_g9651.t3"/>
        <property type="gene ID" value="Gr19_v10_g9651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="810"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9651.t3"/>
        </source>
    </evidence>
    <sequence length="912" mass="96825" checksum="4D33C481124776A3" modified="2023-02-22" version="1">MASDYDEADYATCCQQNPKNPGFEHFVRPLTEVGDVQQRWSTSSSIRQQHSAGPAAAKRTTTTPPRQMVTTVLLNNGDTNKTPTVKMVGGQFKQQQQLVDEYLLDLPSSSSSSASVHSTTFVGTSSKPKLSCNSRKISFCRSRTTPNFERTTTKWRHQHNNNNRMPNLSKFVAQFLPSTECVHRVCPFLFLLLLALLLLQQHFYTEQLERRLSRLEQRWNNVAELLEVPPDFNIEHNAQQLRRTLRSLYDRRRPQRDGTRQHHQHTNNHQQTPKACLCPQGPRGDPGIQRRRRRLAAAAAEPCTRFPSGDAATPWRRMWPRLKRPTARLLQHQQSQRIRPIPLGSADHELRTFGFLYSADGRVLYLRGLPGLPGEKGARGHPGFPGPIGLDGQRGLTGPIGPPGPKGDKGDQQPGPVPPPSFAESRYAAGYSEQGPTTNAHLNHKYHLHQPPRSHTAASSQQAPIVIQGPPGPPGPPGPPGRPLPGPKGERGLPGYDGESKTGPKGEPGQGGRPGPAGHGGDKGEKGSMGLPGRDGRIGQPGLVGPRGFPGTKGEPGAPPLGPYPSYASQNAGGGKHDMNADGNATTCQQPCRNGLPGRDGVPGAKGEPGVPGAPTVLAPVGMERSGTNAALLPGPPGPPGLKGEKGDLGLPGLPGTPGKKGRKHKHKQQQQQQQQQQQQQQQQHAFGEQALQHNQQQQQQQLVLLQQLLLPVLHEQLFRNLSRQLQPLLVGRTVHGPRGPPGLQGLPGHGGEKGERGDIGLPGLPGQPAPPATPSVFTGGGAAGPSKLVVPGPRGPPGLPGLPGPPGPQGRIGPPGTLGLPGLPGPMGLRGPPGAIGRSAVQGQKGDTGPVGPPGAKGDKGPKGDQGLPGLDAPCPPGPDGLPLPYCGDPAPLLENNNFVHNGNGLLVHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID71</accession>
    <name>A0A914ID71_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID71"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9127.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9127.t2"/>
        <property type="gene ID" value="Gr19_v10_g9127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9127.t2"/>
        </source>
    </evidence>
    <sequence length="114" mass="13062" checksum="8DF3CB56032A634B" modified="2023-02-22" version="1">MPVPSSTKCYSDKQKREIVHECIALKNKFLQEKKHSHNEWNQFYANFFKEYGVGHSTIFKWQKQFAANNNTGSMDGAGTQQNNAVEQQSEKIPAEVEQQSEKIPAEQTVDAQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDT8</accession>
    <name>A0A914IDT8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">60S ribosome subunit biogenesis protein NIP7 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDT8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g93.t1">
        <property type="protein sequence ID" value="Gr19_v10_g93.t1"/>
        <property type="gene ID" value="Gr19_v10_g93"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g93.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20520" checksum="ADF290A9409123DC" modified="2023-02-22" version="1">MRPLTDEETEMLTKKLANYIGDNIRLLLERDDGTYVFRVHRDRVYYCSEELSRQAACVTRKRLLSFGTCMGKFTHSGKRFFLHITGLDYLAPYASGRVWLKPQAEQQFLYGNNVVKSGVSRMSDGVEANRGVIVYNMAELPLGFGVVAKSTSDCRRAEPTALVLLHQSDLGEYIRNEALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDX2</accession>
    <name>A0A914IDX2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDX2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9328.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9328.t1"/>
        <property type="gene ID" value="Gr19_v10_g9328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="62"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9328.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47422" checksum="BCAD35E7FC1D6BC4" modified="2023-02-22" version="1">MAKSVANMLKSYKISSTSTPTLTSSTSTSDDSGEIERQQFQQQSDDIKRVNGEMKSQRNASYGDKSLLARSEQGSVWKSIATEADGTKKCVTIKLLRAPFHSPGTAKYALREVALLSALNHPNLIALYDVRLPSKVKPLKKFDDLHLVTEYFGKNLRERIVEKLKNCTLWTHQELSYCIIQILCGVNFLHASGIVHRDLKPTNIVMSDRGNVKILDYGIARDIVPENLTTEAGTPIYRAPEIYLGIDSYDKKVDLWSVGCIFAELILARILFHGTTLATQWKLFNEVLGTPDLKFLDSLGVKETNKQIVMEMPKRESADWTQMIPDNAVPKLISDYLTIENVRALLSSMLVLDPAQRTSAEQALKNAYFDIYRGYLSANLLATPQKVYCTEEFKQLMKDNNIDHFKEKILEQIATFKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEC2</accession>
    <name>A0A914IEC2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEC2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9834.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9834.t1"/>
        <property type="gene ID" value="Gr19_v10_g9834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9834.t1"/>
        </source>
    </evidence>
    <sequence length="589" mass="67025" checksum="F07D38CC45EBD4E9" modified="2023-02-22" version="1">MAPRPQWARPLLLGVGICGTFVVHAVTAAQSKPKTMFLYLVAFMLLPTTASYIEDPLKLMQKLSQEYNILSGRASDVLAQLRLISEKSKDFMRLTGPAGNILAAFMQTVLPISRKPEDPLFKALSVFHTHIKQRFEQNSAQIGGVMDRISLSQGMRDYDRDIDVPLYLLSVSFSGATDPKTSRFWVEKLIGLCKLQHKEPLDLLLKIDNAVNIKCKPRMPKKLLPVTSELKTHFEILLERFRDQKYSQSHEDLFTLYLKTYVQFTAFSEEQAIEALAKLEDFFTKVSLDSEVQLSDLNAQLLALLNNHNSVEICLLRDVYFGYKSERKPLLRMAEILQVDTLKLALIGGMCANITYAGDKEKIEYTLEQLALYTKHITGNVSDWIHNELEDAWPDELSRAAKKALGLDQISDPYAYNKTAHIIKDAVSSRGLPGFIYTILVSLDWDPIANFWYRCNPDYCFPVKGFHGINFVVLRHKVGGQQRAEQAEKWFKTQKSAITKTIRDNDKISDLSSLIRKVEDKIGPIISPSLYRSFVILHVSSLTAKACVLNTGMSISEYTGHPGVTFIEVYTHYWWPTSNDERFKLFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEZ3</accession>
    <name>A0A914IEZ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9295.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9295.t1"/>
        <property type="gene ID" value="Gr19_v10_g9295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9295.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22080" checksum="567FE9BF4891E59E" modified="2023-02-22" version="1">MMNVEDVCEWNEDCVFEWVKMGHFALLLNLFDDMLRRSVEIGPHGIMRIDCNGETEQNVLYILECPSILFKNTATRSIYTSYETRAYYDHVIDVKAFCSADYTIKHETQSITLNEDYPSFNIDLNKSIQDTMRERHNYFSQLSPLPSQWHFLEFVVQFAYSQCCLEERLNLLSTSLAANRAIRKSIGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF23</accession>
    <name>A0A914IF23_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GATA-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IF23"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9639.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9639.t1"/>
        <property type="gene ID" value="Gr19_v10_g9639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="145"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9639.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32205" checksum="BA324056B9896394" modified="2023-02-22" version="1">MEAAPVNANGGYNNKNNNIGSVSESMDAPVQYYQQYFMPQSHHSTLAGSVSESIGEPIQYYQQYLMPQGHHSTLAGGDNLIIHCHWQQQQQQQMELQLQQQQQQQRQALDNWTCQMALPTTSSALAPVASQSPLEVKGKQRRPSAGRQLQCSNCDSTTTPLVRRNQHGQPVCNACGLYYKLHQVARPLALKKETIQTRQGRRRRQLLASSSACPASCLPSGTASATCSTGQKMKDEKHLAEQLQLSAITAFSSGCPASCLPSGTASATCSTIARRKVSAGTTKVPDWTDKKSDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFM3</accession>
    <name>A0A914IFM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g946.t1">
        <property type="protein sequence ID" value="Gr19_v10_g946.t1"/>
        <property type="gene ID" value="Gr19_v10_g946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g946.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8680" checksum="CEF621961C8A9F32" modified="2023-02-22" version="1">MDNAKIRPIPQFKRVDVRRGANSRERRVWYCKCVANCGYFMRATLQNNGRFNLHHTHEFLHVHNNHAIWAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ53</accession>
    <name>A0A914GQ53_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQ53"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1014.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1014.t1"/>
        <property type="gene ID" value="Gr19_v10_g1014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038161244" evidence="11">
        <location>
            <begin position="22"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="55"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="279"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1014.t1"/>
        </source>
    </evidence>
    <sequence length="581" mass="65090" checksum="F8F0D6EE7B19EF87" modified="2023-02-22" version="1">MFVPFCVLFTMSTLCPFGVLSNRNGALRQHIVSPTQQQPQNSSTKLHGTWLARDQQILGELLRNYDRRIRPPAEAGTNAVRVSVNILVRMLSNIDVVDMEYSLQITFREQWVDRRLAYAQMGHQMSPPPPKFLTVPYVKTRIWLPDTFFPTEKAAHRHMVDTENMFVRIYPNGTVLYSSRLSLVCSCPMHLQLYPLDVQHCDFDLISYAHTTRDIVYEWAHNTEPVQLKPGVGQDLPNFHLDYIDTGVECTSHTNTGTYACLRMRLRLSRLMTYFVLQLYLPTSMIVCVSLVSFWIDMHSTAGRVALATTTLLTITTMQTSINAKLPPVNYVKVVDVWLGTCQAFVFCALIEYAVVCYRDCAMRNVRRSGGGSANLRHAQRRPIAGGAGTTSLTRNTSDDTCGDDGQMPTHYGQTEDEWETELGMRELAPCTCELGGIGCAVLTSLGIVPPGFGAPLLNTALLLPLDGGGGGVRGASATVTPHDTNNNNNNNNNNNLSDILPTFQALEMHPAQPLHRLLWMSLKRKLRKPDYLPARIDWYARVWMPIGFAVFNVRKINIFTFAGGGEGVDSATDRRRRENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQE7</accession>
    <name>A0A914GQE7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQE7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10381.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10381.t1"/>
        <property type="gene ID" value="Gr19_v10_g10381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000078">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000044">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="858"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="310"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="544"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="701"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10381.t1"/>
        </source>
    </evidence>
    <sequence length="907" mass="103317" checksum="DF227ADA714A16A9" modified="2023-02-22" version="1">MTNQFTFRDSSSASRVLGFKKIVDLNETMELFHLLVPFFPLVASSIVRFQSFQDLNRHEFGLDDEGSRHCLVLRFTANLINLNLKKQLAVENVDFTSARVKLVGFCSARNELKKHSQIQASWRVGKQRKALKFAFREKRTKRSTTHAEELRWLLDKVEFMDKFKGRSVRFTSGQNVSATVNAPLNQKFVCRDSINLTLQHPRYKDIVVQLVSVANQIELQPIAASSGLGNNVFVCERTRRRTLRESFRSKMTVFSGILLGIGSNLKLKRGHNKNPRAMIGTAIAAMAFLCPTIWSNFRATATKISRKNYESQLYEDLLFTYNKIARPVRNSSDVLLIDVGASLIRIIDVDEKNQVLTTNLWLEMRWNDAKLQWDPYKYGGIRQLHIPSTDIWVPDFVLYDNAAGDPDITIFTDALVSFNGRVYWQPPAIYKSFCPIKVKWFPYDKQECKMKFGAWSYTGFYVDLRQLPRDQIELRHSEKDEEYEYMENGMDLSFFHRSAEWDLMNLTAARHDVLYASCCGPEKFVDITYYLELRRKTLFFTCNLIVPCFLISFLTTFVFYLSDHKITFSISILVTLTVFFLVLIDLTPPTSLEVPMFGQYLITTMILVALSTMVSVVTVNIRFRSGATHQMSPWIRVIFLNLLPKMLLMKRPERPQKCKLSEPGTGQMPKSPSSMSANASPNALASICPSLIAKTPIERDGAQNAKGNGAPNLRTPRRSAPMSKGKVPPIVSPSADLPRVFFPAISANINRPKVLIPPPPYSNSSENAKKCRPSVSSGQNLSNLQISLSNNENRIEMIQGPMFGRSEGERDTRRRANDAIFANLVKQVRFIAEYFQRCEEEAEISDDWTFVAMVLDRLFLVIFSALNMATFSTIISAPSLFDFREPLNVTVPTRPLGQANLFSKHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQW8</accession>
    <name>A0A914GQW8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 9">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914GQW8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10355.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10355.t1"/>
        <property type="gene ID" value="Gr19_v10_g10355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10355.t1"/>
        </source>
    </evidence>
    <sequence length="369" mass="40351" checksum="F0036865B9D259FE" modified="2023-02-22" version="1">MASVPTQKEEPFLNQQAREELRAIAKKILQEGKGILAADESTGSIGKRFETIGLENTENNRRRYRQLLFTTPNFGQYISGVILFDETFRQSTDDGVRFVDVIKKTEAVPGIKVDMGVVPLAGTDNEKTTQGFDNLAERCAEYKKGGCDFAKWRCVLNIGPNKPSDVALTENANVLARYARICQQNGLVPIVEPEVLCDGDHSLERCREVTELTLAYTYKALAIQKIFLEGTLLKPNMVTPGNNSNAMILPEDVGLATVTALRRAVPIAVPGVVFLSGGQSEIEATQNLNAINRVPGHKPWTLSFSYGRALQSSVIKKWGGKDENMAEAQALLLHRAKANSQAQVGQYTGEEHAADAAAGARLFVADHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSJ0</accession>
    <name>A0A914GSJ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Beclin 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSJ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10977.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10977.t1"/>
        <property type="gene ID" value="Gr19_v10_g10977"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6841.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6841.t1"/>
        <property type="gene ID" value="Gr19_v10_g6841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="133"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="265"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10977.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6841.t1"/>
        </source>
    </evidence>
    <sequence length="515" mass="57375" checksum="0D3BE9ABD572B7E8" modified="2023-02-22" version="1">MPLIIVMIGLGGGVPMPEKGATPAPGAATAFPMNDEQKSQLQQPQAVQPPIVHCLVCQCRLELHRSLLSGPAEDATDCASSSIKSCALRSDDAKADSAATFEHRLDLTSAVGTSQSANLLDLVADSSTPLDVPMCKKCATTVTAELNKQLGHLEKECIQYKKSLDHLLQRRADCPFDKEASRIKLDALKSEERELLEQLTLLEGEERTLMHELEAKQAERRQIGQQDEELYRRLRDNHRTLIEQADEQRSLKLQIKQSNEQIRRLSRMNVLDMVFHIWVDGEYGTISGFRLGRLRHDQVEWSEINAALGQMTFLLKVIAERLDLEFVSYELVPCGSTSVIRILSKNGTTTAPISTAEELPLYGSGGWRPFGQQALDKALVAFMDCVCQVEQRLKQYFPSGTQLLPYRMLKDKIVDKDSQYLVKMQLNSEERWTKAMKCLLLNLKRVIGILTTLPMAAAAAQQQQQQQQQTPSPTVESRTSTTTFIAGTVPTSCRPPPTSPTIEEGPSSSGQMQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSP2</accession>
    <name>A0A914GSP2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSP2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10402.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10402.t2"/>
        <property type="gene ID" value="Gr19_v10_g10402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF4">
        <property type="entry name" value="MOLO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038115465" evidence="2">
        <location>
            <begin position="35"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10402.t2"/>
        </source>
    </evidence>
    <sequence length="335" mass="37202" checksum="4CDE930857BDAD7E" modified="2023-02-22" version="1">MARPSLPNRVMMWTLFAPHRSVIPLFLLLSTVSAHKDWTNSAYPDLRGPTFHQCASRMPDNKPLFICDPDRIFNATQLIRINNELAKVAIGTPCPCQRRSQCSSGYSLNGNTFHGFIVSIALVDNLQMNFHSPSEQQLIDRAESFCKALEGRWALGDCGNSVIVFVWRHYKKMVIWPARLAERYITQSERKAILARVNDLVQNDKWSEAISQVIAEMFEELRGDPESRVDTGTLSLVIAVGVASLLTSLITGCVCAFRCCGNLSPSEEKSLSALMDSSSNFLPNSAFPPDSASSPQHLRHSRSPNSPNFGSRRSPTPPPQTTHLSFMAFSDTTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTE0</accession>
    <name>A0A914GTE0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTE0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11189.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11189.t2"/>
        <property type="gene ID" value="Gr19_v10_g11189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038068920" evidence="2">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="181"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11189.t2"/>
        </source>
    </evidence>
    <sequence length="244" mass="27216" checksum="DDD23F846C3DB8CD" modified="2023-02-22" version="1">MARIVLGAFVGLLFHISVVRSSEQLPKIMEEENAMILKKLGREAEEESSIKLGKTRCRLNFVDSGATEHSQPPYSVFLPPFQRPPIRHAEVVEVRDAAVHPELASNFEVRDYPTLKLFKNGKPTEYGSGRDAASSSASEEPSDKLQFHLAQPAKMVSHNVGGRHSAVLLSPRKSSVALPPNRFCLELPNGFYHHPSNCSRIIQCFGSNMFEYPPCQYGLVFNEHTGFCDYQRNVLGCTDAPQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU75</accession>
    <name>A0A914GU75_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10443.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10443.t1"/>
        <property type="gene ID" value="Gr19_v10_g10443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037869919" evidence="2">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10443.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27902" checksum="025EB02EA9A06EFA" modified="2023-02-22" version="1">MVTTTHLTKLLFLQFLLLPPHLSEWTDAMDPRHFWVQTLQHELELELNGTISYLDEASRLATEGNRTLNDIRIRLEKRDEFRRASNELDRRRRLGHTGVHNRIDQLEKERKVEDAHVEREWHQKKAALESSDWLTSNLAKGNAEMKNGEEGEGAVHLQEKGKGKKVRIIETDGREEEKVDEGQIKREEKRRVNGTDEEHRSVLGQDKADDQTAEVQKVTAVVPEGTKPVEAVTEAKTHQQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUU9</accession>
    <name>A0A914GUU9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUU9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11550.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11550.t1"/>
        <property type="gene ID" value="Gr19_v10_g11550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="4">
        <location>
            <begin position="111"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11550.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36828" checksum="E926AB3F870D5E40" modified="2023-02-22" version="1">MPKPNSLVGRIKRLLDTGNGADVQFLVGGGDKKEASSEKYETFTLLLPAHKAILMGASDVFETMFPFDARNVDPSKGVKPVEVPDVEVGGVQGDAQLYYVDDLSGLNGDNAIAVLYAAKKYDLPELVDLCLDFPIPELSNIFFAFAQTRFLGEEHIDMNARALILSEEFLQIDQQSLCEILERDELMISDEIAIWNAALRWADEKCRKNGKEPSAANRREMLGPALFKIRFPLIPQKDFTEKIVSSGVLTLNQMMSVYVYHSHPDTGLTLQNRWDSAACHKDLALSEPNRLFVQHNGEFSAQRSVLAERRFFNAKIKANFGPNFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV97</accession>
    <name>A0A914GV97_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GV97"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11662.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11662.t2"/>
        <property type="gene ID" value="Gr19_v10_g11662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="678"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="544"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11662.t2"/>
        </source>
    </evidence>
    <sequence length="983" mass="107699" checksum="5954AACBBF981B69" modified="2023-02-22" version="1">MHMDSGSNSSSSCSTPPSCSGGTRDKSSSKVRLRHILGRIFSGVNNNGSGSGAEDGGGGAAQEQQKGWHPQKSINEISAPSDVVHRIHVGYDGQRFTGLPPSWLEMLDVSGLTEADQKKNPGAIVRALKFYAAAVKQRESDKFMCPQKSVYPASEDDIEPDDFLFTNGGIGIPNTMHNNSQQQCRHNSNKEEEMLSAKWYDDDGGDTDETAASIEQKGKAKVPTLDVPNSSGGEPTEECAEMAVQKDVGLYHRNNASSSSTADVEEQTQKVADILLEDEADQQQQQSDQEQLVKEDEEENDQHRQPHGMEEGVVGIGCSCLGTRLEGGQSFVPAVPPRKTLPQQQQLLPDALNQRCFTLQRHHFSPADSAAAAAAAPIVRRANSLDDEQQRCATAAAVVAAAALAAAAGAPATMTAREMSPLSSGSSKKKATPPPIPPKPRASTKAYIEHIISNLKNANNDNSQVTRHQSNAAPTANEPKKDVENCSLSGSFISTNGGSKASSNEELHHNTNATTFIVDSGTNHNKSYKTGTNKAFASPKYVSPLHRAYPHNSPTNAEDDHLKNERNNTNNNNNNSNNNNNINKVTTKSQPLRDLNKSNNNNSSSSSIENNGGGCVSTFTSSCTPSPTATTEKVRHRQPKQPKEDSVTKRPQQQKLTNSQVLAELREIVSGGDPLEKYNLVDKIGVGATGTVWSARCKFTEQIVAVKRMNFSSQPKKELLLNEIKIMQRYKHKNLVNYIDAYLTGEHIHPQQHQQQHTLAAPVEQHYRSSSMSKSITSQDLWVVMEYLEGGNLTDVVVNTELDEGQIAAVLKETLLALHFLHRHSIIHRDIKSDNILLGLDGSVKLTDFGFCAQLQPGSKRATIIGTPYWMAPEIVQKTKYNYKVDIWSLGIMALEMIDGEPPYLHETPLKAIYLIAQNGKPEIRKREALSPEFVDLIDRCLSVDPEQRADTEQLLNHPFVLKAKPLESLIPYIKAVKEFKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVD2</accession>
    <name>A0A914GVD2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="13">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="13">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="13">PHB:PPT</shortName>
            <shortName evidence="13">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:84503"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:44565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>all-trans-nonaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-nonaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17709"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58391"/>
            <dbReference type="ChEBI" id="CHEBI:84502"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:44505"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11134.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11134.t1"/>
        <property type="gene ID" value="Gr19_v10_g11134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11134.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33673" checksum="836DE92AE33FB9DF" modified="2023-02-22" version="1">MRADKPIGSWLLYWPCAWSIALGAPPGCLPSFYFLTLFGAGAFLMRSAGCVLNDLWDQNIDKQVDRTKFRPLASGEVSEKEAVFLLAGLLTTSLAVLLQLNWLSVILGSSSVFLVVVYPLAKRYTRWPQLVLGITFNWGALLGYTAVTGTFSSGLCIPLYLACVCWTVIYDTIYAHQDKKDDLLIGLGSTALEFGNRTDFWLAFVSMAMLTNLFFVGLTSEQFWPYFLTLFASASHLAWQLDTLRTDDPKDCWEKFRANQWLGAAIFIGIVLSNLLKSETREAPEGKLKEQLEAADEWESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVL4</accession>
    <name>A0A914GVL4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11190.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11190.t2"/>
        <property type="gene ID" value="Gr19_v10_g11190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11190.t2"/>
        </source>
    </evidence>
    <sequence length="109" mass="12001" checksum="3587301B1468BBB6" modified="2023-02-22" version="1">MNGIISRATHPAPLRRPLFDPFSPTIQTVYCPFPRQWKRKLLGMGVVGTLRLTCSRKGQADDPGLPPFTQGKSLLMDGQPGTINQSVGQNQPHPFFLTRQIASSIITSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVP2</accession>
    <name>A0A914GVP2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide chain release factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVP2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11619.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11619.t2"/>
        <property type="gene ID" value="Gr19_v10_g11619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide chain release factor" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11619.t2"/>
        </source>
    </evidence>
    <sequence length="90" mass="10631" checksum="B63645EA75663AA0" modified="2023-02-22" version="1">MLSSSFSAFRPHKTRCLHPSLDLLWLDLDSLRRCQLEFNIFRFHKIGAGGTEAALFAAELYDMYAKFAARSGTGRRMKYEQMHKNRWHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVX6</accession>
    <name>A0A914GVX6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVX6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11689.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11689.t1"/>
        <property type="gene ID" value="Gr19_v10_g11689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11689.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="18650" checksum="60ADA73EE5B9D3C8" modified="2023-02-22" version="1">MVSVAEGLKCGVKYDVGEKFTQDTLDEFDCVVDGHQCVYAECLGGQSPAWPKFADCKDPNSVNCTHLTRECEQKGGKGCCYVCGTDLCNNKEWTCGAKPSTPEATTSTTTSTVPPPTPEATTVSTTVPDVPTTTTNITTKLPSETTTTAGSSAFRRENIFYGCLILIIMIELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWQ0</accession>
    <name>A0A914GWQ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWQ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11101.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11101.t1"/>
        <property type="gene ID" value="Gr19_v10_g11101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020338">
        <property type="entry name" value="SMN_gemin7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14679">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14679:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11095">
        <property type="entry name" value="Gemin7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11101.t1"/>
        </source>
    </evidence>
    <sequence length="560" mass="62310" checksum="2B41E15C9CF0E9B1" modified="2023-02-22" version="1">MENAWRTSKEKCEGEDETKSAYERDEKEIGARSSDQQQAQEAAAALPDDLSAIPVPTEQEMHPASQHTMYDEQYQRQPPPQQYHHPQQQHRQQYRPRMMTGVYSNSTSSRPVPLAQVSVSGLHQSASPRFTKPIRFPSAQQHHQPPDNEVSTESQKFLGEAAGTRQYPVSLRSYIERAYRACEGAEEREKLENYLRQRVEPLLKSGAIYAVNWAKEPLPHELNFELKTGWIPANLVKQQFQQKLAEKDGCGSGDQRQLQNQSFIQEVDDDDGVEAHDQSELRPPPPRPLQPPLSVQKARPMFQSTPQNKKQLLKPTTPGGHQISPIPEEGELDLDRLVSALLDDHQQQQQQVATTAAFAAAVHQTANMNMGGDAAGGYVVVTELSSCSANDDGKGKKGRDGSATTTTATNAALMHALRMAIILRKMKAAEAAPQTTTAKLLTAADSAVQSSNVELRERFLRILEWLPSRSVSAQMFGGIRLEGELVAVDPTNFDYYLVNNLKTPMGVVEHAALRTRDTIYLEIALDDADEEDEGKIVEQQQQQLLDNTAKVPDEGGEQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYC1</accession>
    <name>A0A914GYC1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYC1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1228.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1228.t1"/>
        <property type="gene ID" value="Gr19_v10_g1228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1228.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26007" checksum="FF5DE9F72ECB3E7D" modified="2023-02-22" version="1">MNQEQDNIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLTFHTSRGQIRFNVWDTAGQEKFGGLRDGYYIQGFFGDYYFDALLLGQCAVVMFDVTARVTYKNVPNWHRDLVRVCENIPIVLVGNKVDVKDRKVKAKSITFHRKKNLQYYDISAKSNYNFEKPFLYLARKLIGDPNLEFVAMPALAPPEVQMDPTLAAKYEQEVAEAASAELPDDDEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZH3</accession>
    <name>A0A914GZH3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914GZH3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12783.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12783.t1"/>
        <property type="gene ID" value="Gr19_v10_g12783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12783.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="44671" checksum="83A8C2B8728765CA" modified="2023-02-22" version="1">MSESDKLTAELNRKFAGFATTAIHAGNRPEQWDMNQVVPPISLSTTYKQSKPGEPKGHDYSRAGNPTRDVLQENIASLEGARFSRVFSSGLGATAAMANWLHAGDHILMADDGGTTQYFRRVSVVHHGVQLSFVDMTKLDDLRAALRPNTKMVWFESPSNPLLKVIDIEAVSKLVKAHNPESIVVVDNTFMSPFFQNPLALGADVVLHSLTKYINGHSDVVMGCLVTNSERLDAHFLFQQLAVGSVPSPFDVYLVFRGIKTLHLRMVQHQTNATAVARWLETDPRVEKVLYPALECHPQHDVHKKQATGMSGMISFYLRTGLEGSQKFLANLEVFTLAESLGGYESLAELPALMTHASVPPEIRQKLGIGNNLIRLSVGCEDIRDLIRDLDIAMKVAMGRSREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZZ7</accession>
    <name>A0A914GZZ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZZ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12924.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12924.t1"/>
        <property type="gene ID" value="Gr19_v10_g12924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12924.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9367" checksum="55F0B4A75649E6E4" modified="2023-02-22" version="1">MMTLNIFSGEWDKLLQRRSSPIMMSWAKIVLRIRKLNSLMKTDDGQLEGLLTSANKKEKGHSHICINIIHRSSRFARVNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0K0</accession>
    <name>A0A914H0K0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0K0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13063.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13063.t1"/>
        <property type="gene ID" value="Gr19_v10_g13063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038032199" evidence="2">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13063.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30461" checksum="471326730454A01C" modified="2023-02-22" version="1">MEEFWVLILLSFFATNSLDKAESVQLEELEELPLQTFDELFVDEWWDKDEAAEDLKTPPTNFGQNVHHQIDRQNTQLGQIEPNSTDPNPPLTESDHSGQIKPNSIDQLEQIESNSTDENPPLTESVHSDNAKNDEEITSNENIAEDERKLEKFDQMKAELMRAGTKNSYTNQINEIVAKELGLSFKTIYAWKREFGQTKPKHKHSHSEQKELMKRYYQIKDQNPKIRDEDIAKTLKIGGTTLFRWKKQLRQHLDQNSVDGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1X9</accession>
    <name>A0A914H1X9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1X9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13393.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13393.t1"/>
        <property type="gene ID" value="Gr19_v10_g13393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Obg" evidence="6">
        <location>
            <begin position="56"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13393.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="36876" checksum="39A7900260A183E0" modified="2023-02-22" version="1">MIDLRLLIAKKGLLIPPCSAHCFLLRSFYTENESSRQDSFRLPVLPKKSRSSGEPFSFVDYKRVFCEAGKGGDGRISFLRLKNIEFGGPDGGNGGNGGHVIFRADSKITDLSHLNDILKAPEGIDGQESCAHGKNGEHLFQNDARGGAGGHGNAFYLSNMVRKPLKAEEGGRGEETRYDIEMRIMATAGLVGIPNVGKSTLLRAISRAKPKVAAYPFTTLNPSVGMVQYGDFFQLAVADIPVSFGILCANEVVMYDADLGRKEAAVVVNKMDLFDGDKMMATIVSKFPKHRVFFVSGRHRLGLEPLLMFLREKHEQFSKEREAKLEIDKEQLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H309</accession>
    <name>A0A914H309_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H309"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12789.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12789.t1"/>
        <property type="gene ID" value="Gr19_v10_g12789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12789.t1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43898" checksum="11619A14F0691B07" modified="2023-02-22" version="1">MSDNPAKVEKRLKEIFVCDDVLFGVFEFCGPFVLGLKVALISNRFDRLVDAHFKSKEWALGHLFFHCGKGNGAGIFKFVDTEIERRLPIPQEPLPDNVIGFECVNISYIDQSLIEFLQRIRPLFDSTGTHLYIGTFETRSWEIIWQQIWPLFKDNIFGFFMSSPNLDRLRKFSPTVLRDCAKLRVIDSFNLFPAFPADDSAGASPEQALAKWLHTPRGDGLPKVLQCQFRLTEMEGLKFEFVNSTHPVNFIICFRTCSADIVPFYMKNNLTGERLELRRFDDKDNWLLVRCPIECDEAQWAKWEQEAAKWDWHQLNRIQINFNDEDIGDELLDTNEGPSGHREQVQFKLGLSSRKLTPFFWNFPDPDNSNPICDLVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3J2</accession>
    <name>A0A914H3J2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3J2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13817.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13817.t1"/>
        <property type="gene ID" value="Gr19_v10_g13817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13817.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34740" checksum="1024CA291C3A25D2" modified="2023-02-22" version="1">MGFVDWSISVKIPILYLNFCISIPSMALYIAEIVTIVRHKTFHNSFYALFVMRAISDWLGVLNSFYTNRLPSTIGAVLYPIYSQFPNWMFAMPFFLTVPAFQANNLVTAFILLNRLTAIIMPTKHEKLWRKFLPLLTIFVLCAPILTCWPVFKMNPIIQLNNPNSTTDRNFVLYEAGDAPSIKYITLNCAVFSAIFMRTFLGHALVASLYLILIITNIDDPKTKAMLYVYYPVVIDTGTVVLSSCLLLWASDTFRQQLTKDFGIIRKTNIQNISIRTTNANNFIIEPTKTSRTIKPPFGRNLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5B0</accession>
    <name>A0A914H5B0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5B0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13802.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13802.t1"/>
        <property type="gene ID" value="Gr19_v10_g13802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13802.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12133" checksum="48968A0B7CA6D025" modified="2023-02-22" version="1">MVHLIVRHTPKSMRMYSKILLQTCATDFALLTNTLLFHQYMFTTDKGESEVIAGGLITFNGTQNRGLNLLAWRLRHANSVHAEAAQIRPVKVPAAASDSFSRGSKCLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5I0</accession>
    <name>A0A914H5I0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasma membrane fusion protein PRM1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5I0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1401.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1401.t1"/>
        <property type="gene ID" value="Gr19_v10_g1401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1401.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27082" checksum="049D0C40E1C154CC" modified="2023-02-22" version="1">MSVDETIRELSGTLIQLKILVAKINEQISGVSGRINITLQTFDDSVSGIANDANKMTKQVDTTIDQIPGSWAFYTLFFTLIAVLVLLSILILINLIIKIQSIYNTLRGDVSRASTPLQSLVQSESKQPLHTQPFPATFHGQAPESTHRLRHHVAVEMEAEPRRYGLGMPPDVPPQQQQQQHMTSLRSATATTTVYHPGPMAPRQMEYNENRGGGRRSANGSSPNSELRGRSHGGSPRAYQADAGAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6F5</accession>
    <name>A0A914H6F5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6F5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14124.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14124.t1"/>
        <property type="gene ID" value="Gr19_v10_g14124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14124.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13785" checksum="F2B1AE1ED934B116" modified="2023-02-22" version="1">MAAKKKLLNSLEAYATINHGDEKTNRRYAAHDNEEAKIIFLNNVHYELAINFEFNQRKDIYDRAEDLLSDWVGSDSLIIMQITEEVRTLAKTFGKMLENVTEHYGKKKEASDDGGDMISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8A6</accession>
    <name>A0A914H8A6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SKP1 component dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8A6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1496.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1496.t1"/>
        <property type="gene ID" value="Gr19_v10_g1496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component dimerisation" evidence="2">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1496.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26151" checksum="577AE99885809EFC" modified="2023-02-22" version="1">MAGEAERVYPPTSTAPQYSEELLQKNVACKCRGGEIVRVRFSLLLQSKTFEELWKCQGLALNELPDDFVFSVESVSSSVFNKVVHWMNHRIGMEDPVVQMDPKTYEAVWLTFTEYERNFFKLNAVRLAELLNASNFLCINSLHLYATQALAALLKGKSLEEIRELIGAKDDLSEEQKKEILAKNVCGPNSVDSKSLFESGDHPGEVGDDGRFRERGLSSRIFKTQIRRVGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAQ9</accession>
    <name>A0A914HAQ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAQ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15368.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15368.t1"/>
        <property type="gene ID" value="Gr19_v10_g15368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15368.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20318" checksum="AF8E91819AEF04F5" modified="2023-02-22" version="1">MAASDVFEAMFPFGAQNADPSEETKPVEVPDVEVGAFKAMLSFIYVDDLSGLNGDNAIAVLYAAKKYDLPELVELEITKALMHTVGDVIGCGADLATRQIIYTKNGQRLETAGLFVDFGADLFPCVSLWNPGNKIEEPKWDEWEKEAIELDWDNQWYRISIDFVDSDIGDGMVEANEGPSEPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBJ9</accession>
    <name>A0A914HBJ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBJ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15593.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15593.t1"/>
        <property type="gene ID" value="Gr19_v10_g15593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038031080" evidence="1">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="138"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15593.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34589" checksum="608D5AECB55D2C86" modified="2023-02-22" version="1">MFRPFLSLLLLILTQICGGRHSLSYSECIRLERWATDGGAGGPNGGQSSVAKVVSVREGYPAYLHCPQPKRQRRKELKAAWTRLSDEALLAVGTSTFTLDPRFQVSKPRKNESDWVLILKRPGPRDQGCYLCEMNTEPTSTLVPTYLKVSIDTEVEEGHTRTTAVEGIGKMHRLNTYLQTSIEGDLLLLNCTVEGETGGELPLEVQWTRDGRPIDIFGRGRYSTSRHVSNNGAAVLFSLRMRAVSPEDSGLYACDGHRLVRSAQTINLVPPPHSSAVGRSPTVPNFVTFCRLSLCTLSWLFVATFFQIFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCR6</accession>
    <name>A0A914HCR6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier family 66 member 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCR6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1631.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1631.t1"/>
        <property type="gene ID" value="Gr19_v10_g1631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1631.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27331" checksum="2BD41395D92183E1" modified="2023-02-22" version="1">MQLSIAQRILDYLFPDKCSDIFFIDFNFFHKECAPLLISRLLGIAITLGSTFLLVPQILKIHNAKSGEGLSLLAQLLGLISAAAVSAYSYEKSFIFGQWGDSLFVAIQTTFIIVQILYFSGNFAYAVAFVSCCWSASLAIFYHYIPMPILTQLQAAVIPIVFLSKGIQIFANYRQCGTGQLSLISVSMQFGGCVARVFTSVQETAGDWLVIAPFLVSSLLNGIIFLQIIYYAKFGTSGTTTEEKKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD13</accession>
    <name>A0A914HD13_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPI-anchored wall transfer protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16230.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16230.t1"/>
        <property type="gene ID" value="Gr19_v10_g16230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041675981" evidence="6">
        <location>
            <begin position="26"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16230.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38644" checksum="9C67AD9EB432E8A8" modified="2023-02-22" version="1">MTLVLIATSLAILAVDFTLFPRRMAKTQYYGHSLMDSGTAAFIFVNALADHDVAARGQSPRQRAAKATMQIFAFRMPTLLALLLIGVGRSVFIQLSGYGRDVTEYGVHWNFFLTLFCVRLFVICVPNSMLVFVGVLLGLVYQIALRFTGLEQWLLRPDFAESRHVFLDQNREGIFSLCGYCFIYAVSLMYARGSNKLMPRDKKLCALNVACGLGFSLCCYGFQRMLEDNFGLTASRRLANMSYSFAMLALFSAICALLQFGQLVVPLPLDAALGGLVAAVSRNALLHFLCANLLTGLVNLLAMASPHFEIDGHPMAETVTMLTYALVISLLIYAIHLARTDLNDVQSPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD69</accession>
    <name>A0A914HD69_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HD69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15949.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15949.t1"/>
        <property type="gene ID" value="Gr19_v10_g15949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15949.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34017" checksum="6F293A5DBAD279DE" modified="2023-02-22" version="1">MSHSALTNKITHKTSSLLDEFKKIQIDEISNEREATNLALLKQRQRTRSFLVMANYEMIKVERVGANDVVALITLNRPKALNALCTQLMDELADSIVSLDNDAGVHAIVITGSEKAFAAGADIKEMVPKKFAEVFGGGFLENWSQVATVRKPTIAAVNGHALGGGCELAMMCDIIYAGEKAMFGQPEIKIGTIPGAGGTQRLTRVVGKSLAMKMCLTGEPINASKALQSGLVAEVFPPDQLVSEAIKLGEKIAANSSLMVGMAKQSVNRAYETTLQEGLLFERRLFHASFATNDRKEGMEAFQEKRKPTWQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD96</accession>
    <name>A0A914HD96_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD96"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16058.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16058.t1"/>
        <property type="gene ID" value="Gr19_v10_g16058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036766531" evidence="1">
        <location>
            <begin position="20"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16058.t1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50685" checksum="985A118B0E8C404D" modified="2023-02-22" version="1">MVTICVIFIVNFVATFGKSQRSAKSAANFVFLTFHNNSDHLYDVNFVVNGRDSLNVIPSLSLTSSKNGSKDVENRRDFLEQFPVMCKSDPRAPSPNRPPTNGPLSLWTAQTGRLSPEDGTLVSDGLSVTTVPRVSPGNSPSHRLIVCVFGDFSENLYEHTQLDLSKLIEHKKCNMNLFIVFLFDWSELIPFLFAFSGKIAWERRLHPQAGFNFSPYVMLHSKANSHKHSAFARVPSIFGAVGGNLTETTFFQSTEVGDVAFIQITVEIATVANLADGSVEYEMIAQYFRETMLNELECKLQEMHRRPRRPWIVLYMTHPYLVSNDEDKAQWFIMNDTDRFFDILKRYKVDLLTSCGIEGMARLLTKKKKEMPEAKLPEYVQTTMAQCGGYQSMDVTLQNECSFAVLDIRSDKMTFRKMNADDGSDLENGQIDRTFEEADDCVLDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEZ3</accession>
    <name>A0A914HEZ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1653.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1653.t1"/>
        <property type="gene ID" value="Gr19_v10_g1653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1653.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10069" checksum="F8FE5CF30670846A" modified="2023-02-22" version="1">MPCRSFPCSFFFAFQPKPQNNDGKSHPREVKDAISKGMQIGRAFAPPLSHQSIIRCGAQTPSVVEAKKRGGGWGGRMSQLAKTPRGRNPTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF33</accession>
    <name>A0A914HF33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16929.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16929.t1"/>
        <property type="gene ID" value="Gr19_v10_g16929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16929.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13378" checksum="D63AC77AA91A1917" modified="2023-02-22" version="1">MRSLWRVNTASRTRASRGTASFVVVCSFAEGIQKESTKGMYSFMNKNVVNKRMNKRLPNSSSSTLGVSAYNLRRWIFKVLYRVTESINFVKTASFCWHKTVYTKKKTSPTRFGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFX8</accession>
    <name>A0A914HFX8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFX8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16803.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16803.t1"/>
        <property type="gene ID" value="Gr19_v10_g16803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16803.t1"/>
        </source>
    </evidence>
    <sequence length="1155" mass="130170" checksum="2D5C01D0D2A2478D" modified="2023-02-22" version="1">MHDEEFVGEYNYVWTSHLRTLELRYPLNPQTGFQPGEMVRFIQLKDGRGPQVVHDLVKEHDLKLEILREPGKDGTISWKAKVTMVFAPPTNERLRKMKAINEQVKGLAYTEDFLEVISFLPLDVVPGVVYEGFVTRLPESFIGVGKKLGSLFCVKHKKNSQFNNIVTDRAKIQSLLEQCPFSDEFPRDDYDDIGLPATVEPTSSNAPRLTDNSAQNGVGVAMNDQLQHEYIYEEDFSLNYAERLHDIEEGAQDLGLIVRTSDEYAVIWSAKHDLVRIQLASGVNEQQWSLAAWVHYRCFQEQSQLHHGVRCNHTAYDITPARGGDCDRIVTTFATEHGKEVAMQCAIANPVAVNSQLFHAYDAFVHEIICPHDRGLKELLQDGQTVKVMCVFADDYVKHRWIAFAVEKPEDTYQKLDGLPPVIDAKVLPYFGRHNNRRVNQIDEQMHMLNVGARFKPPLGWTGAKQTGDRVMNVLGVAIRFERQKTVSVIATAFGLARQPKCLELGTWVEATIEAESDDRALHNHTYESFMHEHSYRVLYSKKISPPMSTRVIMVNGTERVLMCGDVKSILNGLRNTYLGHVEDTQGNIGSAKSGESYLVELGITRHAEDNRICFWNVLKSHGKSVINVHKVPLAMSHFNAEEGKTCDDAHRILLDPVFDAKDHAFESAKPVNAYESMARASQQREVSNVLSAASSSSSSSSLPTQPKQQQQQWVELQQNMPNSSTAQQRLPPSNNSIKNVFTTANVERLKSDALFATPKPSEASAEKKPVIPMTTTPANFDLLESDALSAELKRYEPSAEKKQQGTALVVRKRPEYLLMYNPRHGLCIVLPKYAGVQSAYEFDEKFALGEFYHCSFVRVADQAARGLSYEWMCKGDFRLSNARMKTRLIMGGYVQVNVRCKFSMENLTKLTGDHWIINTDIGNVRFSKDFLDSNDFLNKAVDIWVTHVKEIEKCHWQIVLETWNSLMDESEVRELEDDFVVVPHQQQQQELAQAEPERPLHTHQAETEPPLRNKLYRHSGYADFLFGSEVPDGLGGESYRVQCMADDSDEGNSDTDSEYNTPIANWDDSDSTSDEEEFDDIGIVPNIRSQADGGNAIPFDASKDFESRLRIIGGSSPPPRSTVMGGGGCSSLPPRSSTSDAKRRENSQMLLIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGG1</accession>
    <name>A0A914HGG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17275.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17275.t1"/>
        <property type="gene ID" value="Gr19_v10_g17275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17275.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15960" checksum="E86BF5B01322F91E" modified="2023-02-22" version="1">MNIFEFTDQIRDKDRAIEFLRQRDILRSDPPECPNYQCNRQMTLVKRRDKKDGMEALCGLSNRTVIDWNNFLREICSQQLLNNPIRLGGVGRVVQIDESLMARRKYHRGHEVPERWVFGMYDVHQQIGDISFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGN5</accession>
    <name>A0A914HGN5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGN5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17193.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17193.t1"/>
        <property type="gene ID" value="Gr19_v10_g17193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17193.t1"/>
        </source>
    </evidence>
    <sequence length="583" mass="64517" checksum="16CDD91D234D264C" modified="2023-02-22" version="1">MMCKCSQITCANRSQSAHVADLHFSRYDLWEFGSTDKFEMRHLAVRFVRQTNLARIATNDYPLVALNSHIHVVDPQLGLHDRFQGEKAIELSRSILARKLLRSVDLLRIRNDYYLWWEAFKTFSRLRAEKTPLEKRHIRSNLLDSSAGLLSALKLPNDLDRDGPSTSEVPDSIRAMVDDFAGQIQLNRCEWHSVQFRRFILSAFQRLIFASVQPKPQLVSFPQLVRPAVVEACNLELNLFPLVVESDSYLSLTGVDLPSLISPLIKCQLSCKSNPWPLVLVTSGNVYPPTVSAQSENNSGLFGQKAQLSLLIMDDDWHKCSEICRHLTYSLSAFLARIGLSFSTADVKPPHLFLYERSALTFSHDSSVELARFSKIGDYVSRRAQISKSRPNDGKTDDNYLKMAFVSVNLDSIPVLIFSPKMPSSVSASPTNAVNIPRNSNSRDDGDASSLVRAIAGSLDSVRRQSPGVQVAVGAGGGVFAGYIFGKTSKAFAICVGTGIILLQVAESQGYLRIQKKKLKDDFESARDKLGEMFDGAIDNENVAGIARMSAQNSGKELFKIVAKNARFLCGFVGGILLGFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHF3</accession>
    <name>A0A914HHF3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHF3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16651.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16651.t1"/>
        <property type="gene ID" value="Gr19_v10_g16651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16651.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38603" checksum="8094FD0B47A5191E" modified="2023-02-22" version="1">MSDNTSDEEQQQQMKEISICADIWLEIFALFSPRELGQLMALISDRFDRLVAEHFKTRKWSLGLLRILRAIDGNGAIVKQSSGEQLSIPQRPLPNKVIGFEKIEISYIDRSVIEFLQSIRRLFNSSGTTVAIFTFEDQSRSWDIIRQKIWPLINDNIRHLRVHAYQLDCLRRDFPAILRNCTNLRSIDGLFLEFPADDNADASSAQAVAKWLLTPRGDGLPKMLRCDFDSAGMEGLKGAFVTALEPVNFIICLYFRGCISPFGLTNNLGERLELRCFGEYKWLLLRRPIAREEAKAVSEEGIELEASRKRNRIAINFEDSDIGDGMLDANDEGPSEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHI8</accession>
    <name>A0A914HHI8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914HHI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17003.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17003.t1"/>
        <property type="gene ID" value="Gr19_v10_g17003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17003.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25493" checksum="52F2FC1DD171E74B" modified="2023-02-22" version="1">MHENNSTNGLDSLPRRLLLVRAMRLMLLNDSATIQMQINKKQRLALQIVSHCGAPSGRDLITEQLQNLMELDVFGNCNSKSCDDACYQRELESHFFYLAFENMVCPQYVTEKFWNALRSLVVPVVLNRSVLNGTGIPDNVYIAADDFDSVQALAHFLTALLGDSERYLGYFNWTKKYRRQWDNTKPSALCQLCQIAHKQMQKDKDVIQTVQLDKFWAEKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI53</accession>
    <name>A0A914HI53_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HI53"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1714.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1714.t1"/>
        <property type="gene ID" value="Gr19_v10_g1714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1714.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35378" checksum="8DA278EEDC4F14E2" modified="2023-02-22" version="1">MSSNSTISEVYFELANARPCWTLIIFASIYTILAIVGIFWNFSVIYVTIRTKSLNNSANKLLAIYSFFEIVHQSGHFLFAYSVISGQYLMPYKTVIQILAPSHFAVCCTIFLLFFTSIDRLIAVIFPLRQSENVLFYIITLPFIGLWNFLYVYSQSCDSADKTLVTGTMSGLSSNQCTSSPKFLPTIINVILLTTIVLYAVVAIAIYFRKSPSNSNSHQFNIRIFRSLLCIVSMNIGGYLLNYSYIIIISIIGNDLMSIWKWNQIFGILLNISAASNAPILYFTSTEYRKAFDKEWQTIIKLFNRNSVQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIM2</accession>
    <name>A0A914HIM2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIM2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16982.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16982.t1"/>
        <property type="gene ID" value="Gr19_v10_g16982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16982.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39289" checksum="988665332E5F8FC0" modified="2023-02-22" version="1">MSDNPKKVEKRLKEIFVCDDVLFGVFSFCGPFELGLKMALVSDRFDRLVDAHFKTKEWSLGELDICHAWDRNADELQIPLPDKVIGFKRLRIRYIDQIAIEYLQRIRRLFDSNGTVLSIEAFGLPRSSEIIWHRIWPLINENMSGISLTLYFSLSTLRRFSPTVLGDCPKLRVIYSAFCFPLFPADDSAGASSGQALAKWLHTPRGDALPKLLRCTFDKDGIGIEWLKMEFVNSTNPVNFIISFWNWYFVDIAPFELKNNLTGERLVFQPFDEYNWLFVRCPIERDEDKWAEWQKEAAEWDCYWQWNHIIIDFNDSAIGDGLLDANEGPSELKKRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ36</accession>
    <name>A0A914HJ36_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HJ36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17356.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17356.t1"/>
        <property type="gene ID" value="Gr19_v10_g17356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17356.t1"/>
        </source>
    </evidence>
    <sequence length="356" mass="42050" checksum="63A97132902E6E39" modified="2023-02-22" version="1">MIKSISANLETEQNRLDSGELRSVNHYASIYGPFGGYFEQLDEEELPLSTQTFRIEFSNYLLNYSVINAPKCEADTNLFIFVPSRPESQYRRQQIRESWAADLKRENATLRFVVGWPLRYEFDLLLEEFLTFSDLILYDVEDTYANLYVKVYVSFQWQQYFCRNAKFVLKTDDDAVVDVERLRWWIDHEFARKVALYPASVFGGLWRGVKVIRERTHQWHVPRALYAAKKYPPYMNGPTYLLSNKAVKEILEATGEVKALPIEDILFTGILAGRMHVHKFSVWQHFRFGKYIYVHERCRNDPQDGRKVPYVTALFGVSNPDNIRRAFDELRSVNCSDSWLSIRSLLWEKALKWWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJG6</accession>
    <name>A0A914HJG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17745.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17745.t1"/>
        <property type="gene ID" value="Gr19_v10_g17745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037961941" evidence="2">
        <location>
            <begin position="18"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17745.t1"/>
        </source>
    </evidence>
    <sequence length="719" mass="79511" checksum="B7FE7A63FB45CA3E" modified="2023-02-22" version="1">MRLQILLQISLFACVLATAAFGNKKAVETNAQTNSTVAATAAPPPTAATQLVTGTSTDGRNGQQEEEEREEEVEGMEEEGEGEEEEGEVEGMEEEGEVEGMEEPQSVSEEGEENGRDEEEVGSEEEKSEGDRKEVQRGEVKREGPMKEEQREEEKQDGKRKEVQKEEVKQDGKRKEVQKEEVKQEGKRNEERREEVKQDKKRKEEEVKRYGKRKEDRREEGKSKGERKQADAVPQKAKADEKKRPDEKKLLVQQIAYAKKRSSPESDDSPQPKGHHHDGDGDGDEHNASGEYGGGAKDSYGRGQKKEYGGEKKERKAKQYTENRQYGGGRGRGKYSGKRYGGYEQKEGHGGYGKEGYSKKKGYGSHETAGGYGKKEEGHDAYGNEEYSKKDEYGGYKKEGRYGVYGKREEYGGAENGYGKGYGGKEGYYGGEKQTYDHLQGKREYGSGKTTDYGSGKTTDYGSGKTTDYGSYKQQAYGHNEKSSSYDGKNAYGAYKKQTTYGGGDSSTSYGTQQGTTYSNHNNNHHKPDYSTPFAINSYKKHYYDSKRPNNYCRSGDIQYMRVSIQGHYCSVHGSFSLAMATEYGNEELKKATAYASGESEYGQSGAGGGEYDAQQKAYAAPPRKVRFHTRQFCRYTAASSIRACAFCCKVVARSANTSPDDIVSAIFSFNPAHPSGNGAGIGYGTDNAGGYGTDGYGGGEEHQAKPVFQCVCCAPKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKR6</accession>
    <name>A0A914HKR6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reelin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKR6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17530.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17530.t2"/>
        <property type="gene ID" value="Gr19_v10_g17530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF42">
        <property type="entry name" value="DEFENSE PROTEIN L(2)34FC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502177" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="3">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17530.t2"/>
        </source>
    </evidence>
    <sequence length="1190" mass="130321" checksum="7CDCA9F534F1ACB0" modified="2023-02-22" version="1">MALLFLLFALSFDFSSGWPDGAPCLRTVYESMNPLEAVEHQGGLQLSDPPFTIELDAQCYYPGQPISVCLHGNGSTEFKGFAMQSLVFDAFRVGTRRTGQFLRMDDNGSWQFQCFRIRDSVTHSHDDKKGRMTMWWRGDFNGETVQFVATVVQNLKRFWVKSVVSMPIPPCSTRASFGPWNKGTPTVPPPTDNFKKETFELFNPGSAAQLISEISAVPAEGRSRLLPRPSSPPSQPDPVFFRTPEPATTIATTPSFFRPNQQFQRFGQNSACRDKTSSRHCLQWIQFCPTNPWMGQFCKATCRIISSFLLDDQMHPSQHQQLQTFGNSASANSAHSSPMKRVPPPALSPLASPMESRRLFVPPASAHPPASSSADHSMLNALQLGYTLAGPAQPARLLVDPHTGQQYFVPTAPQPMPYFAAPTPLYYPNQFYPTPASTATAQSQSGFMFANQPPTTLWSPQPLSSATPPSLLRQRAQSPSAVSSALGGRHHHQTQHSSSAYHVEVPLSSVGSMCEEAEFEQYQHQQEAFQRQQQIRLSSESRGSLRSAVGNNRLEMNSNRMDLNGNDRSSPPQTASGHTQSVPPRQLLQLQPDHHSTGGSSSESTSGFASGRDRLRTGDISDGRSPPQSPFMRKERTHFLSGQDEDGNHRRSDSPKSPSLPKPPAPRMKAIRMDIDLNRPVSPPEQRQVSVRTTVVRTAPPTAFTISFNDVSSKAMDIPNSTDRPVETGHDVREPSLQEAARQAPTGRRLMATRRNVPPRPVPERGERIGTDSGDLRGKDSEDGDGHGDELGDDAEDMASETGTYVVESKKMSQSQPPVTSTVSPRGEQSGNSVHPSTCSPSSSASSSSRTPSPSLMEGKGAKRSLMSDLRRLREQKSAATPPKPRAFPPAVPAPQRTLMGQNRPCRQQMPSSNSTKKTGNSPFRPNSVGGGGSRCRSEPRSDGGRFSMRGTQPMKGQPNAMPAKDAAVHQQSPEMVAWLRRKEYDPRKAAAAASTDQSQKETHQRQQEAFMASRSFSTSATTKSPFARWRQNRKTLATGDQRSNRSHDDLSRLGESLDEESLPGVAVDSCSSSLQRTVDELTQKCHKSIALLKLCNQSGLSSSVEQLLERVVEGESPEEVEDQFGAVGSDGKSNSENISDRLERLSSAFDAIQKYLEEQTSVSSSRASLAALGKMATTTESVQKTNAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLA9</accession>
    <name>A0A914HLA9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLA9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2184.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2184.t1"/>
        <property type="gene ID" value="Gr19_v10_g2184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF147">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037631470" evidence="2">
        <location>
            <begin position="20"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="384"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="549"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2184.t1"/>
        </source>
    </evidence>
    <sequence length="878" mass="99910" checksum="9D6ADDC303C4ACD9" modified="2023-02-22" version="1">MRLILILSIFFLLFTFINSQCSTKPIWLTAGEIKNSIEYNSLAQCSPCMKNPEHAKTFGLSFRLPTDGQCDDGLLICYPSTLHGIIGGDGPNIAAVKGQFKVGNKKYNNVTRDCAKHWKNDGKDSGSVWHGIFLYTKRVDGKRHTMMNMSISSKEYDFGLNRRQFSIHFGNQSKFLTYPTVGNEQHVSGIDDEFIGISFLEDVQKGAFLREYVGLWMLGLDMLAPSLQLNINLFIYRGCNCTMEAWFTQPTDSEAPIDREIAAGSVNCIKTINGTAQLGNIGKGESAVNIMGLTDKKADNIVVELLRSSADKDDKSLISFSLWGHKTPELTLDGKGSKQKFQILIHGYSFTIWINGKILGEQRYWPAGWWNGINGNVKVKLTGQMMLLEDPSLDKISDELDSIVLPFVKKLRKVVFNGTTFTFRVQLGDQKDFNILLLHDRPDFHEYIGATILQMKINSTKVVFEVFYYGKLQLNESASENYSFNAGQAYEFRIDIFDKEYQVKVNGESFKNYSNSMPIWTINFLRVQGNVTLLVEPEINFGAQQKAGFSKRLERVLNYGDNVRIFFKVPENAKKFQIYFMHESSEFNKMIGDVVLKLEFDLNSHKVLCSHYLHMESVFKPCKNTSYTTQKFKKGQSFTLQILAAADGYYGHVDEKSPQKFGQHFKPINQSVASKPIPPWAIDHIRFDGDAEVRAIDVIGATKQNSKNNIITWDRIQFTQINDTNGHLKVGERIFILFKLKMALGTHFNITINLFNEALQFHDLIGKTVMKVELCDNILQFNSYYNKHWMVPDPARNTSFTFTMNLAKSLTELKFEITAMDAGFGLSLEGKDEDVNGKKLFYPGNTPTWAVQYITVDYRNITLEEEPKVTCKPEERCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLD2</accession>
    <name>A0A914HLD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2565.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2565.t1"/>
        <property type="gene ID" value="Gr19_v10_g2565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000427">
        <property type="entry name" value="Putative Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2565.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18451" checksum="CB3822ADD6882C00" modified="2023-02-22" version="1">MFNKWPSVAKFWWKFWRIKGAQNPKHFGLILFWVGLAGLLLMAMPGCDGMQIFVKTLTGKTITLEDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGIGGHGPCDTALSAAASSEETPKASAVTSGAPGGGQPLSPMSGSSGTVHRNGHRHNQKCGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLE2</accession>
    <name>A0A914HLE2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLE2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2570.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2570.t1"/>
        <property type="gene ID" value="Gr19_v10_g2570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000016">
        <property type="entry name" value="Polyubiquitin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="90"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2570.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19115" checksum="D9AD759072D11176" modified="2023-02-22" version="1">MSDASPTTASSEETPKASAVTSGAPGGGQPLSPMSGSSGTVHRNGHRHNQKRWKFWRIKGAQNPKHFGLILFWVGLAGLLLMAMPGCDGMQIFVKTLTGKTITLEVESSDTVDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGIGGHGPCECENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNB4</accession>
    <name>A0A914HNB4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNB4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2359.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2359.t1"/>
        <property type="gene ID" value="Gr19_v10_g2359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037504070" evidence="1">
        <location>
            <begin position="16"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="15"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2359.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="25506" checksum="19537B01D809FAD9" modified="2023-02-22" version="1">MRTFLFLAAVRLIVAASILLETDAVGPSSSGNAEPNEGLTLENQWVSAAPDVKLALIGPKQLIGQHNGEIEAHRSVRAELPILTENLGTFYYEMKILEEGVNDGVFIGLATKEMPLSGTHVGYYNGTYGYASDGTIWGHEVAGCSHWGYGRPYITGNHKFVVDDVVGCGMDLATRKMFYTINGERLETADLLVDPAANLSNLFPCVSLWTPDDKIVANFGPDFKFKFTADGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNW5</accession>
    <name>A0A914HNW5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNW5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3270.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3270.t1"/>
        <property type="gene ID" value="Gr19_v10_g3270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3270.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21934" checksum="93BD8590E94F3B25" modified="2023-02-22" version="1">MPFTKSTDRIPKLDKLDPIQLITLDKLNPIQLITLDKLNPIQLITLDKLNPIQLITLDKLNPIQLIRILLSQIERFDQMKGELKRAGLKNSYPNQINENVSKELGLNFTTIYYWKRKLGQIKPQHKHSHSEQKELMKRYYEIKDKTPKFRDEEIAKILKIGTRTLVRWKRQFKQQQLHQNSVNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNW9</accession>
    <name>A0A914HNW9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNW9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3274.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3274.t1"/>
        <property type="gene ID" value="Gr19_v10_g3274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3274.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26080" checksum="D5EC5CD00AFC14C1" modified="2023-02-22" version="1">MALVLNEAKSNREEAFFHSGASKNERIWLAFLKRNAPVLQARRATTTILRKEETMKKSVSNYEQWPTVKVVRMEVVVFEKFDKRRTCGSPCSGRGMCGWLSKLGSVLAAGHPMEDDVCPPVADCAAGSATDVQSIAVALSVEVRARVVRVRQGKGAARRKAAMSVEISLNERTHSLTQRGVAGDTAGLHKIGSKYSPVWQVHVSNCLCTVTRNRGYPTKTLDRDLGATNSIRQMFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP18</accession>
    <name>A0A914HP18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3082.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3082.t1"/>
        <property type="gene ID" value="Gr19_v10_g3082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="170"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3082.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40107" checksum="AB56709623FF8BD0" modified="2023-02-22" version="1">MSILRESTDGGDITTDHHDQQENLGPTSILEPSVEVLLLRARLAKLEGQISSTSSCASFELLDFVGDAADTSDNEPGKIAEHEGGNESAAVDHLLLSSTELHEKEELDQTKEESKNTKESVDKKHEEQMAELLREEMKEQRETDVAELEEQKLSNANKFAEIEQKNALQQENVVKLEKDQNEQQLNIGPNRWDSAACHPDLALSEPARMIVRGKGWGSVIAEKPVSKNPYFEVRILRNTSTILVGLATKQMPLDREFVGAHKGTYAYVSDGTFWSNEVEGTSHYNGRPRIGGKPPFGVGDVVGCGINLKNGQIIYTKNGKRLDTDGLFVNSAANLSPCVTLWGSRAKIEANFGPNFQFNISDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPG3</accession>
    <name>A0A914HPG3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="AlphaFoldDB" id="A0A914HPG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2677.t4">
        <property type="protein sequence ID" value="Gr19_v10_g2677.t4"/>
        <property type="gene ID" value="Gr19_v10_g2677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000023">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF493">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="538"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="930"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2677.t4"/>
        </source>
    </evidence>
    <sequence length="1129" mass="125563" checksum="8C97DD0571696B31" modified="2023-02-22" version="1">MFKIQWVEEALGSQSAYCRHLGGRHLHPAIANMMLSNASTILWIFCAFRIVFGQQQNGTAPLIKVGLLMPHNQSSDLAFARSAGAIPIAVKHILNDNLLPAGTNFSFVVRFEDCVMSMAAGYAFDLMVDQQVDLFIAPPCADSAQVALFVSTFYNIPAITWGQNSDSAFSSQSNYPTMMSALPNYADFGQIVISLCNFFNWTVMALIYQLSETGQCASFQQDMQIAINSNDKCVISYREEIKVKISAAGTNDVQYTISQIQSRARIIILCFDDFVQQRNFVAKLQQGGLDSADYVYLIPGLTMDNGIESVSKCLDMLINFFFFLDGSKATAWWVDSNPTIQAAAYKIAQRSFYLMVDIYGKGQVENGSTFDQEVIKQVAQWPFYCTDCDQSLQVSSYAPLLYDSFYLYAVALAKAINSTGSSASSVYRNGLLLRSQLGNLSFNGLTGENKFGADGLRNCIYLIAMYSSINGDLTSYLWLQMNDAGVNSTWVNASSEQQIWSSRNGAKPLAVPLCGFDGNGCRMDFFTEYRGYVIAAGFLMLIILGSIIFGIYWLFQSKAQEMERQNRLWQIAYNSLTPAGTKKKMMESVRSLQSSSSSQFTRDSSHSHISIKHTFNGVVFILSGERVIGVQHSVGVRLSQQDMAELRTMRLLDADNVNRFVGLSIDGAALLSLWRYCSRGPLSDVITGSSSLTMDGFFIYSLARDVAEGLRFIHASPIGWHGNLRSTNCLIDDRWQVKLSEFGLRFFRAHEKRETKELVWTAPELLRESDLIGSKPGDVYSFAIVSSEPIWDQDDAKANVEEFVYMIRTGGRKAFRPKLEPSSQDLSPALLHLIKDCWDESPAERPKMETVNALLQSMNTGRSTNLMDHVFNMLEVYAGSLEEEVEERTKELVEEKKKTDILLYRMLPKQVADKLKLGQSVEPESFDCVTVFFSDVVSFTTIASKCSPLQVVNLLNNLYTLLDSIIGEFDVYKVETIGDGYLCVSGLPHRNGHEHARHIANMSLAFMRSLGSFTIPHLPTERLRLRIGIHTGSTVAGVVGLSMPRYCLFGDTINTAARLESSSKPMRIHISTTTNHFLVNALGGFVTQARGEILVKGKGVLETFWLLGVEGDPAVTRLQSSDGINATIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPW4</accession>
    <name>A0A914HPW4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPW4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2615.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2615.t1"/>
        <property type="gene ID" value="Gr19_v10_g2615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2615.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8936" checksum="856091D2E92902B4" modified="2023-02-22" version="1">MDNEFVNDKNPADNRPYIVDNFAIDDIRSMLRTAEVVLFKPNFSTRFVINLGSADPPELLQLSRIFICYRKQKSAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQL9</accession>
    <name>A0A914HQL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3347.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3347.t1"/>
        <property type="gene ID" value="Gr19_v10_g3347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3347.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15810" checksum="7194BAC71F3628EA" modified="2023-02-22" version="1">MGTEPWALNRTALNRAGSEPCGTEPCGTEPSGTEPREGKVVRQLWGREENENAWGRGRIGREYHSGQANSEKEGKGKGRAKTWEAIIWMITFSTAAIGSVPTVQCRTVQCPRFSAARFTFQSLALNRAALNRAALNRPALNRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQS5</accession>
    <name>A0A914HQS5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Basement membrane-specific heparan sulfate proteoglycan core protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQS5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g359.t1">
        <property type="protein sequence ID" value="Gr19_v10_g359.t1"/>
        <property type="gene ID" value="Gr19_v10_g359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000454">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF444">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin IV type A" evidence="13">
        <location>
            <begin position="157"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="363"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="423"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g359.t1"/>
        </source>
    </evidence>
    <sequence length="557" mass="61183" checksum="D3C44BB6C14C05F2" modified="2023-02-22" version="1">MPMAAPQTLSKPACLGDTSWEIAVPRDTQEERALEVEQCECPPGYTGTSCEDCAEGYERSGHGPYLGYCVPARQPPARPLCDSAGALSAHPQHDGNCDCKQNVVGVTCDRCAPESFNLAPQNPHGCLRCFCSGITRACESSHWRRNRIELDYARGDRDQLDATTSDAHSPYKPPTQPQVHDGSINFNGFYEARGQTLYWSLPQKFLGDKVTAYGGKLRYTFRFSGSGSLNSDADVIIRGNNIQLQYSNRQQVHADRDNYVEIPITELGWRHSNGVSAPREQLMMVLADLDRLLIKMSYMRECSQASLVSVSLDSADAYGAGETALEVEQCQCPPGYIGTSCEDCAPGYSRTGGGPYLGACEKCECYNHASECDAEYGACIDCQHNTEGDRCERCKPGFVGDARRGTPYDCRPAPEAAVTRPRCECHNHSPRGCDSYGRCILCEHNTEGFHCELCKKGFYGNSTKGTAWDCAQCPCPGAAECFLDARGQVQCRNCPPGFAGRLCNECAPGYTPGQTADGRKCEPIGKHKPSEVEFVPEPDEEFQTHFRQLRRSPQLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQZ1</accession>
    <name>A0A914HQZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2894.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2894.t2"/>
        <property type="gene ID" value="Gr19_v10_g2894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2894.t2"/>
        </source>
    </evidence>
    <sequence length="137" mass="14997" checksum="8B5EC0F2A36C4BE9" modified="2023-02-22" version="1">MQNKQYWPALKWPGAQLATDPPVPFGSDDVITVVAEWKAIKFRPLSEVVKPTRKWRTTNGSAVVVRQRIVFSPGRGGRGMLPSCCGNSWGELLRKRLGGVAVEGPGGSCCGSAWGELLWKHLGAFREGGSDRFGYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRJ5</accession>
    <name>A0A914HRJ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRJ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3061.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3061.t1"/>
        <property type="gene ID" value="Gr19_v10_g3061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3061.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15997" checksum="2CDA4C9FBE6C27E4" modified="2023-02-22" version="1">MDQNRWDSSACHYKLALIGPDQLIVQHWVSVLAEKSVHKTPYFEVQILEDTGNIAIGLATKRMPLNNPVGLDEGTFAYLSLGIFCGHEVEESFYGANGRPHIQGKPEFGAGDVVGCGVDLATSQIIYTKNGERIRPRISALFKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS32</accession>
    <name>A0A914HS32_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HS32"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g372.t1">
        <property type="protein sequence ID" value="Gr19_v10_g372.t1"/>
        <property type="gene ID" value="Gr19_v10_g372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF144">
        <property type="entry name" value="BPI1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038046028" evidence="4">
        <location>
            <begin position="32"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="5">
        <location>
            <begin position="156"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="6">
        <location>
            <begin position="606"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g372.t1"/>
        </source>
    </evidence>
    <sequence length="869" mass="93586" checksum="A24F091008CAFC7E" modified="2023-02-22" version="1">MTWRQWNATFKLLRRFLFLLSVFQLIPISFSSEQSPNRPLFHPQRSIQSAAPLALISDAPIDLHNDQQRPISGSEPLQQRRSASAQHVQRNAQGTTAVAKSAGGGAQVARAHRSKKNERTERCSASAGQCVPPGGGPAYHSALADGIRGSSGIKARMNPRAFQYLSTIALGVLNYQIKRARLPNINQCIPQMSGCVQVYNLYVSRYRCPQRLTVYPAPPNLIVLDVQNLDIGVTGNLGGQIVILLPLALFGIIQVNAYQLNIRVGTYIERGPTGCPVIRVASCAASVGYVDVYIQNGGLLGDIANSQFRGKISEMVRQQIPGQICQRLPTMLDEQLNPKLCSMVPQFIPVRQLLQIAISSFGLGNLLGGTAQCPATCNFVKRKVVAQAAPNVNVTLALPPASIGKNAKTESSDGALQTTPTKVDSFQAQSLNGSAAKGTVNNGRTVNARSVINNGAIGLVSPRLVHQQQRRDIVHLPVAPLAPHAMRPTRATALATFARWRRELSGNEDKARADRATASDSGRLAFVDPGENLCANCPKTGGEDNFMASVLQSMDMSKLDNVFLDVRLLNTHATNRDFTVEVVGEFSVGGRGGTPFGAFPMQFPGYTGGKMVDILVSDFTINSLFYHLQSVGFLRIRMGPETPKYGDLLKTTCTSEEDSGLEDHGVETEDGGAVVSKKGRVRRQDAGDLTGLGVCLGDILPAVREQYPNQLVYVFISTIRAPSILLSSQNGGVAFLNFLVDIDFYIQSTNQKVGTIRVASDVRVTIRTNGAHVTGHADVVSMHLEDVGNQLGLPQDALDNLGTLGKDLMLKTINDKLEKGTTLNVGSGAGGIPINIVDPVPHILDHAILIESDFTMDTSKLGGSEPCEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSI4</accession>
    <name>A0A914HSI4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSI4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3556.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3556.t1"/>
        <property type="gene ID" value="Gr19_v10_g3556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3556.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17026" checksum="8FB8573B5AB4DBA7" modified="2023-02-22" version="1">MCVLPVFVLHFHCGRVPSVHFNQNAKNGIVYADVRPPNISPTKQIRHFADATFRLLICKHQLRSLDAARYPVRPKLHLLSAHVVPFARSHLWWGLISEQGVEHVHRMCNNLAGRYAHLGDPEKVVEKLAKHLTLLNALHDRGVEKNDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSY2</accession>
    <name>A0A914HSY2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSY2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4185.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4185.t2"/>
        <property type="gene ID" value="Gr19_v10_g4185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="366"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="451"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="524"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="598"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4185.t2"/>
        </source>
    </evidence>
    <sequence length="685" mass="75697" checksum="6E0314214234F59C" modified="2023-02-22" version="1">MFGGSSGKGRGSFRKAIYKQLTRPPNTGGESSPSENQTTANATPRHRPPALTFSGPSSTVQQRTSAVDGWSISDSKHILAKSTPAVLCSGSESGGNAMSPLLPPICPPSATKTRSAPTDSKQSAPFPPSSAIGRPRCVSAWSYYQQPFNPASSALANTPLLENMTLVVDVNQNQQCAGTQSGPPSSRSVAVGRGATGIVSPRLFASYDSSGQLQQHHHRSISASPHCKEISWAESSAPLLIPLGSRADRFSVNWVPMSARVTQQQRSSVGGGVPPGIPAGRSTNIYLATRHDHPTVFDFEDWHTSLDKREHIQRFAFQNSSLGSTALDSPPSLGGSVHEINRIIFESQEAVYSLFMKAHKCYDIIPTSSKLVVFDTELPVSKAFFALVYNGVRAAPLWDSKTQEFVGMLTITDFIQILHKYYKNDRMSDGMKQLEEHKISTWREIFREDNSVKPFITIDPLESLHKAVQLLCEHKIHRLPVLEHTTGNILYILTHKRLIKFLYLYMNDLPRPSFMDRTPKELGIGSWGNICTISKDTPLIEAMKIFLSKRVSALPLLDADGRVVDIYAKFDAINLAADKTYDKLDVTVYEALQQRCDWFEGVRKCSEKDSLMTVIDVIVKAEVHRLVVVDDENRVVGIISLSDILRHLVLDPPSATPIMTQAPTTEHQQQMVVEEAAKEMMDFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUC2</accession>
    <name>A0A914HUC2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUC2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3848.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3848.t1"/>
        <property type="gene ID" value="Gr19_v10_g3848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3848.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34213" checksum="196EDBABBE813E9C" modified="2023-02-22" version="1">MGFPRTECGVNLATRQIIYTKDGKRLETTGLFVASAADLFPCVSPSDPGDKIVANFGPDFEYNNTTYELTLVTDQYGNYVIRLHTSSLWSRISMATTMGFPMNECGVNLATRQIIYTKDGKRLETTGLFVASAADLFPCVSPSDPGDKIVANFGPDFEYNNTTYVLTLVTDQHGNYVISHMIEHGRPRDRNYRFVCRFCRRFVSMRFAVRPWRQTVAYLERTLNTTTYVLTLVTDQHGNYVISHMIEHGRPRDRWQLLRRQFGNSPNHYTKDGKRLETTGLFVASAADLFPCISPSDPGDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVG7</accession>
    <name>A0A914HVG7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVG7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14816.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14816.t1"/>
        <property type="gene ID" value="Gr19_v10_g14816"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g4545.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4545.t1"/>
        <property type="gene ID" value="Gr19_v10_g4545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14816.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4545.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13667" checksum="CF589257695F1691" modified="2023-02-22" version="1">MTEFSHRAGAPLECICMALKVHKCQEGVDAQHNPRWSIGMRIGGGIDQDHRQSVYSDAGIYVTGVEPNSPAEVAGLKVHDKILQVNGVDYTMITHERAVKYLKKEPVLDVLVTRAKPKQGTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWG8</accession>
    <name>A0A914HWG8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWG8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5300.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5300.t1"/>
        <property type="gene ID" value="Gr19_v10_g5300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5300.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31854" checksum="20C4CE80C967A1F1" modified="2023-02-22" version="1">MIISGPSLSGKSTFLLNLVAEYRELIDPTPASILYCFGEMSTIVPVLQKAGISVYAGVPPEELIRRQTKPLLLILDDLLMSIDEKYLSELFTKKSHHQNFAIVFVTQNLFERKIKVARQNAQYVVLMRSPNSVLAVRNLGVQLFPRQLDFFLDAYRQATSQPYGYLVIDMSASSDPVLRLRTGIFKEDDQRVIFIPKNGGHLSLVCENSKFLCGLARTRSAKKRTKMLRNANAEQLLSLVEICLNIVATRFTLTTRQEVNEVQSVSLFKKAPDYRDCLQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWS8</accession>
    <name>A0A914HWS8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWS8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g52.t1">
        <property type="protein sequence ID" value="Gr19_v10_g52.t1"/>
        <property type="gene ID" value="Gr19_v10_g52"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g52.t1"/>
        </source>
    </evidence>
    <sequence length="604" mass="68342" checksum="CF0BF9F3E4C7A2E6" modified="2023-02-22" version="1">MSIGGYLFSLALYQLLYAFGNLFGSPIRIWQLSFIGGVLLNAGAAANAPVLYFNSTEYRRVFKKEWRALAERFGIKTVQNVATTQVRSANPNKIHSSQQMQSIQINRLGAVNEELDCLIEVIEPVEFINWAACKSKFTRPIKVHVSNQSSRFTCPIKFHASNKSSRVQSKFTCPIKVHASNQSSRVQSKFTRPIKVPRPIKVHASNQSSRVQSKFTRPIKVHASNQISRVQSKFTRPIKVPRPIKVHASNQSSRVQSKFTCPIKVHASNQSFASNQSSRVQSKFTRPIKFHASNQSSRVQSKFTCPIKVHASNQISRVQSKFTCPIKFHASNKSSRVQSKFTCPIKVHASNQSSRVQSKFTRPIKVPRPIKVHASNQSSRVQSKFTRPIKVHVSNQSSRVQSNFTRPIKVHASNQSSRVQSKFTRPIKVHASNQSSRVQSKFRVQSKFTRPIKVHVSNQSSRVQSKFTRPIKFHASNQSSRVQSKFTRPIKVHVSNQSSRVQSKFRVQSKFTCSIKVHASNQISRVQSKFTRPIKVHVSNQSSRVQSKFTRPIKVHASNQSSRVQSKFTRPIKSIKFTCPIKVHAPNQSSRVQSKLTCPITNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX17</accession>
    <name>A0A914HX17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5264.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5264.t1"/>
        <property type="gene ID" value="Gr19_v10_g5264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5264.t1"/>
        </source>
    </evidence>
    <sequence length="416" mass="48071" checksum="DC9E32D37BCDC6B9" modified="2023-02-22" version="1">MRSVFCVQQLLRKGYNVMGFQSRKRINGTPRKRFRPGRTIGDSALTQQPSRRILLFTILLQNSRMNFGRCSICTLNFDITDISALKCGHTYHYECIDKWIMNSKTCPNCRTTNIRRDITKLFFDECDKSFSQFPEEPINTELVAELKKIRDEKMALELTVKEHKEKLVFFDLKLKQEKAKGDQHALQLQTKKQHIRHLESQLFDQSILKEKNDTYKRRIVASDFYAHLMKNGGDDEDIDKYIKLNGQPDEAKFLKLMRNQRDEEIKKNKKLGSEIKKERLERCKREKEVGELRKENEELRKENEKSKKRKVDGAGGTTNSAQYQTRPSFGFSFTDPNDKGEVVHAAKNFAFEGDSSVEILSGSDKPSTYSNTNYKILDQFDPIHLSAKKKLPFHGLLDSAPLAPAGLLYSDHSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ34</accession>
    <name>A0A914HZ34_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional polynucleotide phosphatase/kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ34"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g512.t1">
        <property type="protein sequence ID" value="Gr19_v10_g512.t1"/>
        <property type="gene ID" value="Gr19_v10_g512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02019">
        <property type="entry name" value="NK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g512.t1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47346" checksum="E640F990307AE8ED" modified="2023-02-22" version="1">MSKRKNDCDDQEGKPEPKLASIFANASQRLRGVWKVVPDQLFIYTVDGIEHQQKIAAFDLDGTLIKTKSGNTFARSGDDWQFWSSKVVGALRKNSAKASLASERCRGGGIISRQKKGLVDAGQFKRKVQNIVNAIGVPLQVFVSVGTANYRKPYVGMWNRMENEENGAIWVDREGSFYVGDAAGRLKTQNRPKNDHSCADRLFALNLSLNFQTPEQFFAKISAEEPFRLPEFNASQLLREHSHQFNPKDFKMSGTVHPELVVLVGSPASGKSTFARRFKNEYVILSQDELGTRKKCLDQARESLRKGKSVIIDNTNRDAATRKDFCDLAASFRLPCRCLLFACSPAHALHNNTFRQVIAGGEADRSHDKVNEMVLRTFFSAYQKPTETEGFSEIIQVNFVPEFEREEHRQIYAMYLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZE8</accession>
    <name>A0A914HZE8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZE8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5495.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5495.t2"/>
        <property type="gene ID" value="Gr19_v10_g5495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765345" evidence="1">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5495.t2"/>
        </source>
    </evidence>
    <sequence length="192" mass="21354" checksum="BAE162E8FDED4B11" modified="2023-02-22" version="1">MAYIFILHYLLYFVLLSDCTAVNEIRARRNVTDSGGAASSPAACKTECQMESDGHTQKCTTKCQMSMPFQVIGHHQQQQIQVPTTQIFTKMSETREFVQQEDCVKFCQEKGIAKSAEECRGKCQSVFRNSAVTAIPQLTLNVPLVIKTSETHEFIGQFEDCVKYCQAKGIGKSAEECRGKCHPIGGKTVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0D6</accession>
    <name>A0A914I0D6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0D6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6327.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6327.t1"/>
        <property type="gene ID" value="Gr19_v10_g6327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6327.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15745" checksum="2F8EDB71CAF8E776" modified="2023-02-22" version="1">MCFVIFHKSNTLSPHFKVFIRLMVYERATDIFWDYNKGTLHADSVPTLIRTGVIKTHADQTVREVIDKAVNKFYNQLLEDDNGDDKFYKIVAIFEDKQLNMQIQREMGAEPNAEYTAILLGNNGKNGNSELEHATDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0K5</accession>
    <name>A0A914I0K5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0K5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5777.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5777.t1"/>
        <property type="gene ID" value="Gr19_v10_g5777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF262">
        <property type="entry name" value="CUTICLE COLLAGEN 34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5777.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="33405" checksum="97348A26F7C783F1" modified="2023-02-22" version="1">MDVLKKWTNPDEAEAHPFKTCAMNYDTQVKAYKFVAYSALTFSLAAAVAAFITLPLMYNYVSHVRHQLNRDMVLCQGSSSDIFHEVEVLKSAPFVMPGNRTARQAGYEAHAAGSPSGGGPSGASLGRAGGGHSAAGGGACKPCCAPGPAGTPGRPGRHGKPGKPGAPGVPGATGAGPAICEATPPPCPRCPQGPPGPPGELGPPGELGTEGSSGRPGPEGVPGEQGPKGAPGPPGEKGPVGQVGEAGPPAPNQPVVPGEQGPPGEQGPHGPPGPPGHPGSAGKPGAPGPKGPVGPEGAPGPEGAPGPLGPLGQLGGSGFKGICPKYCAIDGGVFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0Q4</accession>
    <name>A0A914I0Q4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0Q4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6227.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6227.t1"/>
        <property type="gene ID" value="Gr19_v10_g6227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="85"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6227.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40015" checksum="5DE878416BC14A89" modified="2023-02-22" version="1">MLQQVNSGIKGKMKTMLRKAKNKIKLKKHKFFDSRDQFSEESGSDYFHDCPESENESMEDNLLKCKVCWDGVPLEQLCFCDRSMRVKSEGNSGEEDNANANANANANKSGEIHEETTHAFCSQCLEQYTNTAHQEMPFAKGGLGLRCMVPKCNNPITWQEIRAFVPSKVTRSLEDRCAELIVSQSKLSYLERCRKCNCAVEMGISPEEQLIFCCPECASKFCRKCNEAWVDEHNGISCEQFATKQKRQHNLDERLTAVAVHKCHKCKSSFIKRSGCNRVTCKCGASVCSICWTTNVSYEHFCECFLPPSLLGRCKNCGKCLLWHNAKENEEREMERIRKESDAGDGASASQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0T2</accession>
    <name>A0A914I0T2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0T2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6438.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6438.t1"/>
        <property type="gene ID" value="Gr19_v10_g6438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6438.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30403" checksum="6B77C0FA35FDF588" modified="2023-02-22" version="1">MLPPLFSQFFIELLLIVVVAIDVNLLPMKFVFSSPLLNMSQTDKSVRQTQIWGMPSEQGQPTRVKFSDIDCARVLLADDRAYVEQRAVSPLRFNDPPGDALPMNCTSIRGRYLHFSQQPKDRGTDYYPLAFIRLVYTVNRAADYLFIEMEFASSYAPQNWYCYAIDKKASATFHHQMHALASCFPNVLIIPREKEYEMDRKGHNLNHDVQMKTNEELVQIFKWMNGTNDIQYTRIGSNHVDFGKHKWSLSHLKLFRNGELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0Y5</accession>
    <name>A0A914I0Y5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0Y5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5597.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5597.t1"/>
        <property type="gene ID" value="Gr19_v10_g5597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5597.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16946" checksum="ED19FC7AB6B9E99D" modified="2023-02-22" version="1">MPSLDIGAASTFTFPVEFRQQSYLSRWLQIFEFMKQPLYYEIIFIISGEAACMKCADCIWIFEEKLPPFSGATHLVLMIFFQHNGLCWQPTDLKLINDYGVPNQEFMYPHFTMKSPLFNPTVRFAFFVTLDKKHVIFSGVFMGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1R8</accession>
    <name>A0A914I1R8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914I1R8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6696.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6696.t1"/>
        <property type="gene ID" value="Gr19_v10_g6696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="126"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6696.t1"/>
        </source>
    </evidence>
    <sequence length="713" mass="78913" checksum="B9B6BBE129A50954" modified="2023-02-22" version="1">MVKDATPVWISLPINLGRLADVGDWGDQSSGSSILYSVGAAATIGAMGLWWMWSSRPSLKKITQLVDPDQQTRELPDGSRVCKYLKSDALMRFIYSDAKTVYEAVRRGARVSNNGPMLGFRNNHGEPYEWLRYTDALERSGRFARAMRALGLPVGQQCFVGIFAKNRPEWVLVEQAVYAFNNVLVPLYETLGPDASVHIVNQANIELVFCDAIAKTKGLLERKSACPSLKFIVLITSANEELDESVREDAAREGVQLLSLDDFERMGLRDEVASMPDVPPSSDDLATICYTSGTTGVPKGVMLTHGNIIADCTTLDYFKNSHLNHKDVMFSFLPLAHMFERVMQTAVYCEGGSVGFFRGDLRLLGDDIKTLRPTIMPVVPRVLNRIYDKMMAEANKSILSRLVVDAAVGLKTREVNNWIVRNNSLLDQIVFKKVREGLGGRVKLMITGSAPLSETVLTFMRCATGAIVCEGYGQTECVAAATITIEGDPIPGHVGAPAPCCAIKLLDVPELNYFARDGAGEVCVKGTNVFRGYYKMPEQTADTLDADGWLHTGDIGRWTQQGTLKIVDRKKHIFKLAQGEYVAPEKIELIYMRSKYVAQCFVHGESLKTCLVAVIVPDPDVFPAAVKKALGIEGGTMEELCQHELVKKLVLDDIHEVGKKAGLFTFEQAKDICLCAEQFSVENDLLTPTLKSKRPQLKAHFERELCTMYDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I227</accession>
    <name>A0A914I227_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I227"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6155.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6155.t1"/>
        <property type="gene ID" value="Gr19_v10_g6155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6155.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27136" checksum="AC919493B4F0D639" modified="2023-02-22" version="1">MDEAESLLFARMSKVILAPPNPALPTFQMLFNDDKEIAQQIMSNPTTDGTTDQKSQKVQMLKQMDSIVKVYMKLKNSPGGWAELVQKMYADMVLAKNSGVGDSAQLRENCRKALQLIEEEHRLGGIDLQKIEPFKDFWTLVKSSANSLLALFNGPFRYESVGQKREEWKTENVFRLLKTFTGDSAIFKRIVGKNGKTDGKKRRRKRCYTILVLFGMILAVVGVLVLACHIFGKEPDIEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3M0</accession>
    <name>A0A914I3M0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3M0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7193.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7193.t1"/>
        <property type="gene ID" value="Gr19_v10_g7193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7193.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22976" checksum="27AA39FD0C7693B9" modified="2023-02-22" version="1">MAKGSKKVDFDPYKVLQLEYGCEPGQIDKAYKRQALRWHPDKNPDDPEKAQKMFLRIYEAYEFLKDERARMDFDEDIEAKRRRAEFEAERQSVSSAQRKVHLAKLREAEAKVVAGQKRKSDQQNAQDKLIEELRREGQRMMQRLREAEEERQRRAQKQPQQQQQQRPTTTPSASRQLRQEVDELEKALFGGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I402</accession>
    <name>A0A914I402_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I402"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7107.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7107.t1"/>
        <property type="gene ID" value="Gr19_v10_g7107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="170"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7107.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40181" checksum="9067BB8111B22C1A" modified="2023-02-22" version="1">MSIPADSANAQIITTAEHWGPSTFANLDSSTEELLRLLRAKIADLEHLQAMEALQTKVKELETDHRTLQEKVVKLEEYQKEMLLRMDELNCQQTMNSPTLSASFDLVALNETEDKATDGEQLLPENSALRAASQLATEPCSKIDQALQANGVTEMKYRKLLIDHNVLQALLIDHKAEIAEMKRRLNPQQNRWDSAARHRDLALTEPDRLIVQHNGRYMGDYSVLAERQIPKENVGIFYYEMTMLRKKGRVHIGLGTTNQRPLIHIGHDEGSYAYGSGGYFGVTREKAKFEQGDVIGCGINLATRQIIYTKNGQRLETAGLFVSSAVELFPCLTLFYPGDKIEANFGPNFNFKVAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I465</accession>
    <name>A0A914I465_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I465"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7344.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7344.t1"/>
        <property type="gene ID" value="Gr19_v10_g7344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35017">
        <property type="entry name" value="PROTEIN CBG16223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7344.t1"/>
        </source>
    </evidence>
    <sequence length="521" mass="56639" checksum="60670B803E655749" modified="2023-02-22" version="1">MARPNHLKSFLLCAIVPITFILISSRYTLQQRNELTMDSPELLEKDDNGENGMDAFESMEQSSAGPMVGEKDELLIEWPQGWHRLLLRKFGRRALPIDGVKAKAMPCCAESIGQHVCNELRNRNPLLFRKRCKADADFAILQCCHSCRTNVAELGRELFAAGLKSRHCFDRHNRHFCAHFVHQSGMWAANVGKSVNCNGDGAALAFRVCRRSCGFCDVKLYQQQNRNCISRLWKIATTNGTTPTTATITLNGERWKPKVIMTTTQPQPLKSSSSPKPTTTATTSSSTATRIASPASSPPTLLPTHLTPTTPRLRPCTLPSLPPLPSIPLPSMPWLPSPCLPLEPIAPLKWLTPATIATSTHSATRPRPTANPLPPLPVPLPPIVPIGRPPKGSSSRRRSGTTITIAWKPSPSAELPIPLPDEIIEAILNKLSGIDVDNYAVGECRECDEKSAESVEGPESAEKSERAKNSHEKSGEAGPAVAAAAAVQAEEVALLLDVLLKAAATHLMETEEETAADVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I485</accession>
    <name>A0A914I485_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I485"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6740.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6740.t1"/>
        <property type="gene ID" value="Gr19_v10_g6740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6740.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11756" checksum="AFEE31D981D57F27" modified="2023-02-22" version="1">MDIAQQPERTAQGRHRVDIGRRESRRKNGIANPDVRVVRLFSLAAQKFISDICLDAMQQARIKGLGQVKKGQREAKYCLTNELLQPVLEEYGIQMDRPPFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I492</accession>
    <name>A0A914I492_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I492"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6473.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6473.t1"/>
        <property type="gene ID" value="Gr19_v10_g6473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6473.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23947" checksum="14A4DC7C712D2CB0" modified="2023-02-22" version="1">MAYQQANYPNVWMNSSRPNYPNAWMNPRKEGEFVTEQRCSCPTSQLYAIKFNKVKCKLMNETNQGCEICCIGMILCMLFAILLMLFTALAAIRYDSGAIIGCIIVSVLIIVVLILYTVFSEFTHTALEALYKCRSCGHEVHKTYELLPQPFGCAGGDIFNDCGLHATTSAAATAIIGPNNLLTASVERSNAMHFEDAMPMPLSNRTLDMPYIYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4S5</accession>
    <name>A0A914I4S5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g6882.t3">
        <property type="protein sequence ID" value="Gr19_v10_g6882.t3"/>
        <property type="gene ID" value="Gr19_v10_g6882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF224">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="3620"/>
            <end position="3642"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
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    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="373"/>
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    </feature>
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        <location>
            <begin position="670"/>
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    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="725"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="976"/>
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    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2248"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2351"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2392"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2442"/>
            <end position="2481"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2483"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2559"/>
            <end position="2593"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2597"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2641"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2685"/>
            <end position="2725"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="2727"/>
            <end position="2766"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="3013"/>
            <end position="3101"/>
        </location>
    </feature>
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        <location>
            <begin position="3703"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3907"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3712"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3725"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3933"/>
            <end position="3949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="3952"/>
            <end position="3961"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2275"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2361"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2380"/>
            <end position="2389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2424"/>
            <end position="2433"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2452"/>
            <end position="2469"/>
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    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2471"/>
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    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2515"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2583"/>
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    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
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    <feature type="disulfide bond" evidence="3">
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            <begin position="2737"/>
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    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2756"/>
            <end position="2765"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6882.t3"/>
        </source>
    </evidence>
    <sequence length="3961" mass="435162" checksum="F51BA2738F192901" modified="2023-02-22" version="1">MISNKTFKHLAPFLCQILYQTFGIFAEEFPYSIGDLHTFCPDSKDFWHSVGVNCFKMTPIDQRMDWAEANAFCDLSINNHSDALHLDNWLLHRDLSRKFLLQRAQNGQNEFWTAWYIEVRQKKLPEIIHRYGSSQNSSIYNPAWASLEPHLANSESGRWCISWGAALLDETNFGWHLRNCTDQLPVICQTFACYLDGAGLPQHRCADNSACISRRALCDGVSDCESGDDELAQNCDNIAAQKCDDIEEIFTKLSSNSYGDIFPIGWQIPVTKFKPKTCLAKREKWLIDQKPGARIKLDFLALQLGPNNRLSLRDLDTGEHFLIRQSDDKFPSILGANRLEILYERFETQNGDENVAERRGFHLHYAVDDANVCTRTFESWNGSFVVPMNVPDTGRYRTPMQCQWTIENRNRGIVVVKFPVFRLSPGDWLGLVLDEHSAHVGHNFSSSMPAPSVLVTNAPRIQFVFSANNSSAGDAGFRAVFQRSCTDQLISSSPSGNVQISLKKAIADGPVNCSMRIEASKNGPFSLFIDYLNASENDKIYFLNSDGHGLDNKSFVGIAKEFRSFTSAVLLNFVLNSSSLEANIAYSIDCDRPRLWHSAHQMAPNSNMNNSLSKKFERLVQNYLPFRYRIPSVPCHNSKGNKSAELICADGGNLVMSGCSEDGNSAVPTHICIVPRIKNGHATELNRQLGILRYRCNSGFASMQAQQSICTKSGQWIPEPKCSEIRCADPAPNVMPNLAFFHPPDRYEPAKLDYRTLSNRFGNLITYKCGNGTMPRGRRSMAQCSANGTWTTVEIACKKIGCYAMNVELGNFSHFWTLPGAVARIECAHGTKLATQNLPKCILDGNGMAQWEGIPAQGIKCQFENLCKRFGQNPCGPTGICIALNGTYSCNCTSPTHRFNKSASFGEQCQALDECAEGRWPCSSGTCNTTSHPLGRYKCVCPPGTHFLYDTKNKTKNNLIIPATQWLIPGHSCIILRCPTIRPLSQLFVVHSSQPQHPVNSTLVVYCRHNANSALIGPETELKCLPNGQWNGTMPTRCQKEPFCQAPLMPNVATRIRGQKFAEYVVNSVVEFGCVQWTHNRQKGSDFLMVGYNRSICLATGNWTNAPPTCILPQCSKIALGIRNDGMHISLTSGQKWPTNELFGPGAEVKINCAKSGKNWTMICKRKANFEMVWSMDEMPKCEVNTEEVAVVGTCDMTKLAKISRDLLIASRDSVLVGQEVFFKCAQPNYTLSDQKARKCVKNSGKRAARAAVDEQLPVGDLPTGDQWHELIKTAMPESDVIFDSVHRLYGWQKSNHWTQNVANGSWIYWPSHHGKSSLITPSMEVSAGDWLSVSVELGPLPCSNCMVWISYFAADQSSSAFPVEHFNSLGAIMADPVIHSIQFFSPHPKLRIQISADDKSPNFLVERVKLISTACPALNLSPVTNFPRTPAHFENQTISAQCQLGKTLRLICSPLGQWLLPENEPLAYGCGCQPPLALNSHGKCGIKEALLCHVCSSDTDTACFSPTGAEDADVARATAATITKRCTSPDELCMSQSRAHRAHGTQVPFNIVRRCAERAECGIFKRNVSARESCRTDLDGVETCTICCSDDLCNGARPRQLLNGGGLVAVKSLMALSSSTTTTTTITTTLSTPTSSVLQKVTTPVITSSSSTTTTSPSSTITTITLPTRTAQTTTTTQQIPIATTRPSSTSITTMPSSHFVLREKQNSDEFELNSAPPICVDQQPLDLRCLAQIRIRHRMDNGQPEPTVIPWPNVIDNDPHFHLQPMNINISKPHTFMGDEKEIIWRAVDLHGVVKICVTKLVFDGTSSTNERQDLPKGIDIECPDWHIREVNVSAEFGGDPLTDGPPMIRAKYPPIATKKPDELSFDPPVGTHLALGAPKLVFVRLNGIQKCQFWYQTLSIDCPLWTLGAGNWRKFECINELNGLMRCKRNQPCPGGREYPRGMRELRCWRNRPGHGLTYTTDQKSGENEEISLIGEAQCLPEASSLVVMLSIVVASDNANCTKLMARQMNSFLAQNCPGIQWSSSSTNADLAHSNLTGHNFGTETTDGGNDQSVVLCIQRVSSSSRLGRPTFSGHLDMPIVEGQQCPDGSVQTRHFSYHLQCPNGWAPNELLRCEMCPKGHFSSNGTCAQCPAGTFALRAGMTKCTSCPEGTSTVGNGTVADFQCLTRCAPGTFSSNNGLAPCRACPTGKCQQFGKSQKLAESLANSEMPQHFDCTLTGCSGHGKCQNGICQCDLGFVGPDCSILLDLCSAQFCLNLAKCVFDSSNGSSCICSRGFFGQRCEHSAHSNRLTTTDVKHLSTTSSKMQNGICKESNEINECPNGFCLGGFCQCNAAFVKSTNENGQICVPINACLATKPCQKGATDCLHDSNGNVQCVCGEAWAGELCEQQSQSCFLPQNQCLNGADCAWEIKNSTLSTRCLCPVGFNGERCEHQNDQSDLLEQCQHEHRCGTNGSCQLNNSIGILFCRCDRGYFGEFCEAELNPCSSASTSPLICYNGGICQPMTSEKAVCQCPQGWTGGYCIGAHRGSAHCSCPEGYGGDSCQVELSPCTKWPEGDAGICGNGHCLAKGNGHNAKFECLCSNGWTGPNCNIPLGAKECEKTTNKCKNNGTCVPLIDNGIQKWTCECSDGFWGNRCEKRVNYCALNGICLNNGRCKSVVGGDNHYQCECDGKNGFFGQNCEQTAKPCDRNPCANGGKCSPNYADPTGFKCECGPNYVPETNCTRKLNPCHWPNYCNGGQCELLPNSTDSPHCICPPDSMGIRCETRKLSHYDLHFLPFLNSSSSIIQKIRSPSFSCLAITQQSFSLCFWLRFGQTDGQTNKAFPMDLSRIIYISVNELNSADIKNAQRILQFDQFGVNIFDTKLQFDYGHALISHLWHHVCLTFDTAIFRLFLNGHFVDARSGKNFSKNHSKNFCQLLLGEHIGEEAAHFVGQLSQVELYSKRFDDAQIVRMAWNCREWTHRQEKTFSIVEWAHFTTVDVFNKAQIALFPGICSESDCQPGSESDCGHGKNLKTPPEVLFCPRSQFITVPVPNQRLIQIQWEGSLEKMFRPTGTSPIVRFESNFRPGQTFGWGQFHVVYLAEDALGNWATCEFDIVVSPTKCSDLFVPGTFNKLTVHQFRVEEARQAEKSINLKCLSTELVSNVVAKPPFYTCDRLGQWDRWANFGRPFTLPSCTPTENAMQEVVGDLHFDATCDEAANYVLKVVETIENASKNAGAFCERPQCAGQLGIKTECHGEGNGGAVDNNDPDVPSLLSGAGNRVRRVPPTGQQQQTAVRVLFDLSVNNSKRAVAPVIRDAMEAKFGSNFVGETTRLQCSNAFPQLHINGDAKIAGSASVAMASDPPLVQCATCAPGETWQQIVRKIATTTKDESVVNSDMSGSCVKCPANSYKSSPGVQPCTPCQDDRITGGVVGCMREIDCYLNCPPGSVYCSMTDTCTMCAHGQYMPYSGRLQCIGCPPGTTTEQEGSTSADQCSVRCALGEELGAGEQCEMCTRGTFRAEGMHACRHCSLGFTTRSSGAKSASDCAHIFCPPGHFRNTTIGPDHSDNQLISSLASVCVPCAIGYYQECDQANDGTCKPDEPEPCPDGMECVQTRGQTYECHNLPNINRTDHGDVWRRVWIPMILALFAVLALAVLSIIFIKNRQKWLLMLNRHCPCTFLLCCKKMTVDNLASNEYTRTSPPIVTEISQNVQQQTVVELTAASNENSRSSNTEKSKAHGHDIVASLRPRSASESASSRSNEKVDDPLNEIRSGLMEVMNATELDDGDESNGSSSSHRLTETFGRGQQYFMPTSSRRPQLTVQTRFPITPNENDTIAHHQQTFHRRFRRSFSSSSSSSAVDEPPLVRAVPIHHRDGRSFLGSARATDAIGMRNFSMGEEHNEDGTHTLRRPGGVLVGLRCRQFEPGAGVAGGSVPLRSSLTGRSPLASPAGKSGTSSSGVVPAEQTTAVPSYDDDDDAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4W1</accession>
    <name>A0A914I4W1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4W1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g691.t1">
        <property type="protein sequence ID" value="Gr19_v10_g691.t1"/>
        <property type="gene ID" value="Gr19_v10_g691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g691.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="13932" checksum="228AF95E452FDD70" modified="2023-02-22" version="1">MRSPETADVRPEGRARLAMARLPFPCQLWRLHSEAATTVSSCDLLAGAVSRRPAAQTMCAHTVAAAYAVQRHSRLGAVSPFPLGGLAVFVGCGPTPTGQHAFLERANARSSPPIAFASMFRLWTCRAISVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4W2</accession>
    <name>A0A914I4W2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CD2 antigen cytoplasmic tail-binding protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4W2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6637.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6637.t1"/>
        <property type="gene ID" value="Gr19_v10_g6637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6637.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29137" checksum="F0646B93087BE72C" modified="2023-02-22" version="1">MEHRVKRSRIETEDEVVDDDNDGGETAETSMKLTTKKHTLDSDEEDETDTHQRLDMDKVEGQEESTLEYEGQVKIMPFNMKDDLEEGHFDANGTFIFDKKEDVIKDAWLDNIEWDNVKNAAGKHWGKLDDEEGKKSDDEKEVEPKDVYRRLLELLNEKETIAGALKRLNSEKRMNAAEERKRRWAAKKSGANVQEDEKSKQVAELTVLADSLVSLGNMEAYQLNQEGINALLNALKTANRIPGAKKATMDMFSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5R5</accession>
    <name>A0A914I5R5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5R5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7148.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7148.t2"/>
        <property type="gene ID" value="Gr19_v10_g7148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7148.t2"/>
        </source>
    </evidence>
    <sequence length="108" mass="11953" checksum="A7E21F0BBC316970" modified="2023-02-22" version="1">MNTELRLALSDLGRGRNKLLQAVRNVSGARLLFVSRQLVIVAKCWGNPNITFDIGIEQDDPDIPYTFGQFETQLNAICSLISNLESAEAIHHVASYLDVTADLFIFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I696</accession>
    <name>A0A914I696_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I696"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g701.t1">
        <property type="protein sequence ID" value="Gr19_v10_g701.t1"/>
        <property type="gene ID" value="Gr19_v10_g701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="171"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g701.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37180" checksum="26DD77426BAFE97A" modified="2023-02-22" version="1">MNNLHIKEALPENATTIWPLLLELYAHLQMGTPKIDASQLSEALKSGLAKALLIYSNEKSDELAAYALYFTLTLREFGKMFMLEDIYVKETFRRQGIGKAIFSELSKLAFVQQCPLIECKNMTNNSSAVGDDERLYWWRIEENEFAELVNKTNKLKINVAKIPIVLDGDVINLQQAKALAGDWISLLNDGNLECEHYEMIKNLSSTFMNGEFGAIFVEHFANGQVIGMALFSRRGFSTWHGQFLYIDQIFVRPDCRRKGIGTAMVAELVKIAQFQNIKCINWRASDNGDKIAEAFFNSICSVKSTENLIYRWHIMEKPPAHCSANKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6D7</accession>
    <name>A0A914I6D7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6D7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7920.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7920.t1"/>
        <property type="gene ID" value="Gr19_v10_g7920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="531"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="720"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7920.t1"/>
        </source>
    </evidence>
    <sequence length="1221" mass="140505" checksum="28EFA63E5E1FF90D" modified="2023-02-22" version="1">MIVSGSTGSGKSEWILRFLRNLDKMVTEQIERIIYCYGELNSNVLNLQRAGKIGAVPVTVHNGVPPEDQIRERAKLGKLLLILDDLVVGMSHHFLDTLFTRGSHNWGVSVILVTQHLFNKELRVARNNSHYLVLMRNPAGELQTRTLATHLFTSRFAHFIEAYRDACAKNFGYLLVDMHPQSPEALRLRTHIYGRVPLRSKHVKKLQSNAQLLRRLARTRCSRSAKNLLTPPNQQGGGLPAIAGLVASIVHTKRYLLVPEEIYTSLSQPLDGTPVGLVRSRIQQTKNEGDEINYQQEFKRLNKLSKEEAERPVDVRLQNLEEILPKQTKIMPQPRPQRKRKSVVIRRPTKTKKEEDDDDDDEVWEDASPRTLRSSKTSVSSERPDANYPMTKNGILEHIRQNAITLGVSEDGKILKPDGNVYKTSNFEDIVVHLLNKDKRSQFKNAPDVNSPVSFTSVEPLLREAKARNKQITRRDVQNFLATQRAYTLHRQAKRRYRRLPTLAPGLHTEWQADLAMFDRLSRQNRGSKYVPWKLLTDQGKEFTAKAVQTYFRSKDVEHFCMFTSPQFHAGMAERANRSIKERLYRYFTEHNTQKWIGVVQQLVKAINHSYNSSIGMRPVDVNFKNAEALRQKLYDNAAKIPRRAPKFKVGDRVRIEKYKHVFQKGYLPRFTNELFMVVEVHSERSPVVYRLRDSKNEIIKGWFYANDLCKTLESKDQMHDIEKIIKRKKQHDVEHVLVKWKGFNARYNSWIPASSFNAEWEVGLAVIVYPHSWPSIGTVEEQFVQIDWKTGNTVRISVPPSNVTNPYELSKNLYKLLGEGSEPLAEKVRTAQIAYTNSTSVASKWARQEYINQRTREKRSVVGQKEQFQKDIDTLMDFYGVDEEDAGREKRATSKIPIKRAGEIAESYQKRLDEYFTSLKGSDLKLLGELEQTKLKEEIARMHKDDRAILDCYQRKWEWRHGYRRTAGCYCQHLCEKEASPELLVQFGGYNVFRGIPYQRGGGVGSVFRSLMRYLLPIGKQIGAAIGRQGLESGNRVLTNVLEGKDIKEALVTESKSGGKKAQFLSRVDFDIGNQELYLLNNLDLLFTIYKAKDSFLLQTLLGNDTNKYRLAVHDVKIYAKMIEVQPSFNMSLYKSLEKQPATYAVRKTEIKSSYISAGRYEFEYNVFSATIPRRMTIAMVGNAAFNGDFKEVNLNSQIGDSNDIDNDRQKYFKDALLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7H8</accession>
    <name>A0A914I7H8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7H8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7344.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7344.t2"/>
        <property type="gene ID" value="Gr19_v10_g7344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35017">
        <property type="entry name" value="PROTEIN CBG16223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7344.t2"/>
        </source>
    </evidence>
    <sequence length="522" mass="56799" checksum="7B9214FF3D3A47E8" modified="2023-02-22" version="1">MARPNHLKSFLLCAIVPITFILISSRYTLQQRNELTMDSPELLEKDDNGENGMDAFESMEQSSAGPMVGEKDELLIEWPQGWHRLLLRKFGRRALPIDGVKAKAMPCCAESIGQHVCNELRNRNPLLFRKRCKADADFAILQCCHSCRTNVAELGRELFAAGLKSRHCFDRHNRHFCAHFVHQSGMWAANVGKSVNCNGDGAALAFRVCRRSCGFCDVKLYQQQNRNCISRLWKIATTNGTTPTTATITLNGERWKPKVIMTTTQPQPLKSSSSPKPTTTATTSSSTATRIASRTASSPPTLLPTHLTPTTPRLRPCTLPSLPPLPSIPLPSMPWLPSPCLPLEPIAPLKWLTPATIATSTHSATRPRPTANPLPPLPVPLPPIVPIGRPPKGSSSRRRSGTTITIAWKPSPSAELPIPLPDEIIEAILNKLSGIDVDNYAVGECRECDEKSAESVEGPESAEKSERAKNSHEKSGEAGPAVAAAAAVQAEEVALLLDVLLKAAATHLMETEEETAADVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I871</accession>
    <name>A0A914I871_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914I871"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7540.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7540.t1"/>
        <property type="gene ID" value="Gr19_v10_g7540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="146"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="261"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7540.t1"/>
        </source>
    </evidence>
    <sequence length="464" mass="52470" checksum="8BBF79833CF26465" modified="2023-02-22" version="1">MFGATFVLPGGIQAAPPPQILRNAYKMRRRWWRLLLKLFMYSTAIVCALALLMISITGDYWKPSSVSAPSFSLSLQYSLRPHNATFKHRIKDTFKHRIKDTFKHRIKDASGATITITELLLPEGSASLEERAQLLPEQISNATVSPLLLMWDVDFGNNLRGCADWNCRVTRDRKRLRDADAVFFTAVPEDVQPLGHQYFVHYSQESPVHSLYGSADQPFNMSFGFRMDTPAASPYGFAARLAFESEPKIEFWHKTVNESISGKRKAMAWFVSNCGAPSGRNWVADELQRHGVQVDVFGTCGTLSCPKGPSCHRMLDRDYFFYFAAENSICKDYLTEKIWDQGLGSLTVPVILRRSVGQHLLPPNSFIAVDDFASVAKLADYLTALVDNTDQYFEYFRWRANFAAVPLNSLTDPMAERLFGVCQVCRLTRLKRRPTARLSAPWHLCCEQSGQLINELKGRPAATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8E4</accession>
    <name>A0A914I8E4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8E4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8432.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8432.t1"/>
        <property type="gene ID" value="Gr19_v10_g8432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8432.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9685" checksum="A124D80AB494A729" modified="2023-02-22" version="1">MHKREESFLFFNKQTKKFSTKFMCSDNDELLKDSCALKLTLFLLNRTQKNRANPNFSRKKHRRDSTYTSPTFASSKECIGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8K8</accession>
    <name>A0A914I8K8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8K8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8286.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8286.t1"/>
        <property type="gene ID" value="Gr19_v10_g8286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="855"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8286.t1"/>
        </source>
    </evidence>
    <sequence length="912" mass="102957" checksum="35C743CC64CD22FD" modified="2023-02-22" version="1">MLKRKRYLPIDSYLEALTTPLERKQKRDQFYENIRFFYKRKWGFAFKPPSANGQEFDLFEMYEAVTSLGGWQKVTALNRWNEVLQLLKIDECIQMAEHAVQLLYMRFLSKFEQSETNNDISEEHEAELIAGRTSRFKGVTSLTQANYAEPPFSVPKAVSSTSLPDFHKLAFALLSGLPNEISFGLNILTVLSHPGPFVLNFAHCPQLIGILVALCGVHVNVEGPSNPSQLYEWWCQSSGYDFAAFWADSCVDEAHLWSAVYNPDGLNMDPANLDLFEATTSQLNRDDRLDLGIPINWRIFNILAIFHNLSFEEANFAAMGESHALIRLLLLCCNCRWQVLRRIAYETLSNIAKNIKLNSSSNALLNTVRRGLHSDDKCTVMRSMEIVAGLCATPANEVIVCDFFEESQILHRIFELLSLKDILVCVCAMESVMAISDLGRTACEAIARCGRSIEMLIGLLTTDAVSFGTAGLAGMQVVEVQGLHTRPYVAPNKKNPPPPLKLQPVPSLVQQRQQQAVLSSTTAAAPFAAEATTATRTNPRESATDQHRHSTASASHQLYNNSTNCNVQFTTQQQRASTRKKVYLKSPPLPLRHQQTPEGLPPLQNGLSTPAPLSRACAASERDFMCEWLMQFEAEAEDDDWSDDEGTDALMGATAGPIEPCARFFATASQMLFHVYNEHLVPLVQQHSSDNGEPPRIRCRWPLCDNTPRTLWSITTHLQDIHCTESALESAMLQRLEMGYHEYVYHIRQQFQRSRERPPPQNGYSDFAAQEAIRRHAFTNLRKEITDDSEGPVTRSIRLTSALILRNICRHSVTGRRKLRLHENFICWLSLSRMESARTLAHCLSEIGRHANNETEQQHNNNNSSSGDEQQQLQQNQQNTVWWGQTPETSTIGENPKLKYPIDSKTRSRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA12</accession>
    <name>A0A914IA12_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GBD/FH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8677.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8677.t1"/>
        <property type="gene ID" value="Gr19_v10_g8677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056771">
        <property type="entry name" value="FH3_FHOD1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF4">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24959">
        <property type="entry name" value="FH3_FHOD1-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="58"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8677.t1"/>
        </source>
    </evidence>
    <sequence length="1220" mass="135444" checksum="3C40FDA698A59B36" modified="2023-02-22" version="1">MTTFHRLNVHHHQLDFPQHPQQQFDAPVQLQLDAPQPLLQGMMRFIDEEFADGEERMGGVGSTTVLVERAQKRMKTDLNNNTKQQQLEEWDSDELGEEDQDGLRACLLLRQQPALRVKAIVDKLLYTSGREQRRALFSLKSLFQEDKDLVHEFVQNGGLEALIRLGRNSDQNHQNYILRALGQLMLYVDGMNGVIAHNDTICWLYELLDSPLFERRPFAAELSAPRVEWYRLVVKTAIKLLLVFVEYTESNSLLFLAAVAKIERTKNRPDWFSLMRILNDVQASDEETLIFGVTVINKTLHGVPDQDTFFDVVDCLDSQGMENAIRTMTRMNNTQLNQQCALYEQELRKEDAALDSDSSSLGGGGGGGVVQNGHIAKMRLNGNAIATDRRNAMRKRQQEHEEQIRHSSKNIISKLEEQQRKLSNEVVKKMAPPTTAAAGLTNGSSTLDRKPSQKRLEMNSSLDEMAERFEKSLQLNQPRIAPGRLQQPPAPLTFQAELEKENIISNGADQEEEVEAVQEAAKPMKAPPPSIPTNLFSPTDKKSMTFPEPEKLKEPTPPPEPEKPKRVILEDDDGGGGGGGGFAAMLQRRAKKMESGSTLRKGLMEHKASESEAKWKEAAGRLKDKPMIINDYDFSECLEFDQDPIVLARAAQMAQDKGFLPGSSGPGGPPPPPPPPGGIPPPPPPMFNGLTPPPPPPGSLSVPGGIHGRESSPGPSSSKNTLLKLHWKEAHHEAPPVPALKRKGNFWTKVQTPQIDTSKLARLFEQKTKEAVTLKKTGTETKPQLLQVLSVKRSQAINIGLTKLPPITVIPTAIRKFDAAVLNKEGIEKILSTMLPSLEEVERIREAQLENPDVPLEATFVGVHVGLSKCGARSGRSTDGVAMGMLLAFGNTLNGTDIKAFQLDYLNRASEVKDPVHKYPLTHHLAEAMLDNYTDGTDLYGEFGSVSRSSKLDFDSIFDNLKKMESDCKACFDYVAKISQKDNTSSMKNKVNDFLTEVAERIHRLKHVQKTTTNRWSAFLIYFGYAPGEVKDQKMVNVFKMVIEFALEYRTSREKILQARKRLQEKRERNKTRGMMIGAAQNAAGMQQRKRSSGGGAGRGSGGGGGGDLPLMTDKERHQEMSRMLAGGGVANGDETLLRKKTEAMKSGVGGGAGPVGADEDELLDGVVRTVTAHADLRDAGRRRPRAFNRKSQDNVLRRTRTIRQDQLVELNNNINNANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAK9</accession>
    <name>A0A914IAK9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylated adapter RNA export protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U small nuclear RNA export adapter protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHAX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IAK9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8819.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8819.t1"/>
        <property type="gene ID" value="Gr19_v10_g8819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006408">
        <property type="term" value="P:snRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039047">
        <property type="entry name" value="PHAX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135">
        <property type="entry name" value="CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135:SF0">
        <property type="entry name" value="PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="12">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8819.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21554" checksum="E8C34B9EEB3CCF51" modified="2023-02-22" version="1">MVPAEIFVPHKLLTPAYAQSKLFEVDFDAEALSEEQLAQAIADALGETIPELICKAVHFTGKLHAVELFKKCQEVERNGGMLTQNRNRRRTPGGVFMQLFNESTDVGEQQKKEMYKFGAEKQRQSGRFPKWWDKRKEQKEKREAEKRQLNQPETPDIIKDSELPRSNELIKPELNVPSGSMEDIPQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB11</accession>
    <name>A0A914IB11_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8302.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8302.t1"/>
        <property type="gene ID" value="Gr19_v10_g8302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000046">
        <property type="entry name" value="Putative B-cell lymphoma/leukemia 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1055"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1085"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="208"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="391"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="653"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="830"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="955"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1113"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1239"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="858"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1122"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1255"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1273"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8302.t1"/>
        </source>
    </evidence>
    <sequence length="1302" mass="137356" checksum="0FA38D5EFA3E1E67" modified="2023-02-22" version="1">MTIKRKAEKEHRPASPTQIHVGEREAARHNSKPAAKTPSPDRQSANSGGSSGGGGGARLRSHNRLQQQQQMVSSVVCSTPTTMGKHRNPSGNSRSVAASVTTAPTALLPPPPATNGPKKRGRKRIVQQEISNVAAGDELKEQKGRHQPEGQPDKPKQGDGTPLTSSDSGISESNATEEGLLCTNVVITTMARHQQYNNSNHLASIAEEEPKTAQTQRATNCTTLNDGGVSSSRGIAVGVKRRRGRPRKKRAETVEEDEAEEGRRGVEEEEEEEPMEEDEEEEDSAAGAGGEATDEEQDDGTHQKDGIKFTETEPAAKRRCRRNGGHRTGVSGGRATRDVVICNECGMKFTINEFGAFIEHKIARCQTDKSSSSSSPLGLLASTDEMISAASLPPAPTEQTSFSDHSDLLLFSPSQGSASRTDECRRRQRPLDMDPRLHRSSSANGLLLQHTPSTGNSSRVQSAQQHQCCWASNGRREQGTDTADFEHRSKTDEAVPPSATSPAEPGPFTCHSCKTLCPQIWALLEHVFTEHGFRISDDDLPSFAYPPLIGDADERKGGKTETDQNQLQHNHQHNNVQRPQRLIPSAATAQQNHQQTELAAPTATTATATTRALFSASSASLLTPRRTRPFGSSASKTSSFVDAFCSERLREMAERAGNTPPGGKDGGPPICRPPTSAVEEPSSMVVDHPSPSVLPSSLTGGFVSPGGTIAQSLVAALQQPPIAAQMPQTVNDLFQPQILAAIQQYYIQQSAQQNIQRENAAAVGAILQAVTSKNANVGTPSGNTTPNPFLPPVVTTAAAASTAFLSNLMAAAVAKRNGTPKGEITAELPAPKALLGSPPPLSLTPIPSLQHRATPTTSSSAGRVVAGGSAVTPSPGALRRRSPMVHHATTASSSLASPNTQTSSAFVSPIPGGSGGGGCSRLLTPSGRSRSAANVLHGITAAALTPRSSLGTAGVVLQGGADTPGTPFGDNSEDALRQEDLDDGSPMSLAEGEAEGDELSDRLIVVDGDEEPPCEPAVKRDPKARKDRCTYCQKVFTNRSNLIVHLRSHTGEKPYKCQLCPYACAQSSKLTRHMRTHGQQGKEVYNCNICQMPFSVHSTLEKHMRKCVVQNGGFQHGGGTNGKRDGASPHDGKGNNGTHFRRSASLKNTPDAANSVAALLELSKGPVSVGGAIIAEDDDGDDADAERAPRATVTATAGAPLPANIAQSNRLVLNWLQALNAQSVNAAGEGRTGIAVGDGLASAEQHQQQIGGNAGNNNHNKAANNNNGTVGGAEEDVEIDTEDITEAADLALIKKEKFETSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB80</accession>
    <name>A0A914IB80_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IB80"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8981.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8981.t1"/>
        <property type="gene ID" value="Gr19_v10_g8981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF523">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8981.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12796" checksum="3518FDD883749F9E" modified="2023-02-22" version="1">MFHFLIGLSMCVWILCGAISTLGAYCYVELGTSIRRSGGDFAYLCHVKWNAIAFMFMSVGCVLIYPMMLAIQANTFAEYIVQGFGLREMLPDDSLEQIVFKKLVGFLTLSRDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBN0</accession>
    <name>A0A914IBN0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBN0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9346.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9346.t1"/>
        <property type="gene ID" value="Gr19_v10_g9346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051652">
        <property type="entry name" value="MDM2_MDM4_MUL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183:SF32">
        <property type="entry name" value="MITOCHONDRIAL E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183">
        <property type="entry name" value="MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037575523" evidence="5">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9346.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39350" checksum="8541DDEBB0B2CBFE" modified="2023-02-22" version="1">MFNFFSIFLLLLIALLQIVEAIEIWVKPSNLRYTAEIICLNIDGPLTIGQATHASYFEEVGTTGYVNIGTDLSRCDDANPNVKVQIKNLDHPESLWLTKLDLPYESMEFEIPKTELLARKSAVVLGFNIAASAHKIFNFQQSSANFVFFKLPLVGYELEIVCGYMHADGMAQYYLIGSGVQKHFKNLIHIPIFEMESLAFCSRGKIGLVIHQNDRETTKYIELTTKFFGGHMEFDIDINKETVRPTPQAGSDNECLVCFDGQREMAFRPCGHVIACRKCSKKIIIIPSGASSSITGQAKSNNECVFCLKGQREIAFRPCGHICACRKCSKGKKKCPLCRQQIKEVFLIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID85</accession>
    <name>A0A914ID85_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID85"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9772.t3">
        <property type="protein sequence ID" value="Gr19_v10_g9772.t3"/>
        <property type="gene ID" value="Gr19_v10_g9772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="384"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9772.t3"/>
        </source>
    </evidence>
    <sequence length="589" mass="66883" checksum="0064E353EDCECA62" modified="2023-02-22" version="1">MSISPKSTTAGDITADQRNLGSTFSNLEPSEQVRILLARIAELERQQSTNSPTSSASFDLLEAAADDRGKIAAEHGGGNESAAAKDGQQTNTAQLEEELHQMKKELKNMKESFDKKLEEQMGALQTKMEKYQNKQQQTIDSLTQKLKVSIDQLSLKHQEHEKLLNAHKNLMEEKIDWLNDDQQKLVSIDQFLLMQSDQKALLQRLNALEQKLMNSEQQKTDQKALIVMEERVAKLELKNKELRAEHEKLSTDHKNLKEEMKEQREMDALKQQKETNHKIDSLIKDQQQQIANMIRKMEQKQKDAQKEFQRKLDESLNGQAMVVAKLEEQKQSNANKFAELEKQKVSNANKFAELEKQKQSNANKFAEIEQKNDKLEQYQNEQQLNIIDLQKTVATLTETGLIPENRWDFDDCHSSLTLIGAEQLIVQYNGEDWGWSSVIAEKTMPENPYGISYFEVTILEKTTGSILIGLATKQMPLDEFVGDYEETYGYGSHGIFLGHEVDGCRHRLLSGRPYIGGNPKFGVGDVVGCGVNLATYQIIYTLNGELLYTDNLFVESADDLFPCVSLGRPGTKIEANFGPNFQFNISDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDI5</accession>
    <name>A0A914IDI5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridine nucleotide-disulphide oxidoreductase dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDI5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8889.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8889.t1"/>
        <property type="gene ID" value="Gr19_v10_g8889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="549"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8889.t1"/>
        </source>
    </evidence>
    <sequence length="628" mass="69357" checksum="A51B3B2427B5FB85" modified="2023-02-22" version="1">MTPRHHVASSPALMEHAKAFNRSNSSKRICVVRRAGSDVDQQISSVVASACRAVGRDPSTDAFSTTHFLAVDHHCAGKLLDRVRRQGLPLIFLNGDCVGGFAELKRLMSNGFLAESLCAHDFGLVVIGCGEGNAVAERAVEEAVKFGKRVALVEVKQQNGRGRNAFVDEQIAKEMANRAALMRHSIEEAQLKGWTVECSEGGRVNFWLDWRCVREAIVQKTLLKRQRTEAAFERGQVQLFSVTACHFSGTHELTVCQMDTDTNLAQSKLAKICADKFLLVPKSESKVLENVPGAKEFCISNEELFALKHNPGRTLFFCEDDADPQLLESAAILKALGNDVTIMTNTYSPRRIKPSKLDCFDSEFILSIKDKLCQLGIRFFISLPTKFEQLRASTDDKSAILRVYATSAWSKPAEKGGAGDWAPFLEEFNTVVISVGRRSHSAEELVLANVQSRNSNVNCSPTTDSTAGCASISSRKLSSSELLLAPNVYAIGDVRLEQRWTGGTSPPAQSEEGNCRRVRMLVRRMCEANVETMENDTPMVRTMLIPPTEYAGCGLNEEETERKFGRHLMHVYRDGHVPIAAEKAKMICVKECVVGLHLIGPNASQLLNGYALAMKLGLTKKQMEQNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDT9</accession>
    <name>A0A914IDT9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDT9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9686.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9686.t1"/>
        <property type="gene ID" value="Gr19_v10_g9686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9686.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29936" checksum="190886C32470B4CD" modified="2023-02-22" version="1">MDPDNGWYDAKKDTMILTLMLFVCFDKFSNEGHCTQIKILDDCNGFIKSRPNEAVCATIGLHVNHTIKLVRELYGLNMHLGILHHGKLHSCRHLVKQGINQIWRGMLEEGKEMPLQLKASLLAVFAFSAVSLTVRARRGAMFWRCVAVALCNFLTTDANDFQKIVRKETTIENGGDGGGGWIIWTVIGFLCLFPVIVGLWWWHRKRVSPPATAPATALAKAMATAIALATVIATATVADGSPPFPARDEMIKELKVAQVARHKRLQIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEB9</accession>
    <name>A0A914IEB9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEB9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9111.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9111.t1"/>
        <property type="gene ID" value="Gr19_v10_g9111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9111.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="13085" checksum="A201D8E636258807" modified="2023-02-22" version="1">MSDQCPSMYHSNKLFHSLLFPKTNAIMSSSTAVIMLLVLAGAFVVQADAAGINRFKRCPTCYGPSYGYNGYGYNGGSAAAAASAAAAGGNAAAAAAAAAAANGGSAAASSAAAANGGYGGYGGYGGYGGCTTCGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEJ0</accession>
    <name>A0A914IEJ0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione synthetase</fullName>
            <shortName evidence="1">GSH-S</shortName>
            <ecNumber evidence="1">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914IEJ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9172.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9172.t1"/>
        <property type="gene ID" value="Gr19_v10_g9172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036975385" description="Glutathione synthetase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9172.t1"/>
        </source>
    </evidence>
    <sequence length="529" mass="59595" checksum="60F4EBD447DA6AFF" modified="2023-02-22" version="1">MANILLILFLFCFINFGNATPTTHNQDKTDKEQQYCVSNIEQDPQILLEQCLDAKDWALSNGLVKLVVVSTCPECRTKTEKPNVMTQFSPLSLYPSPFPRKLFQQAVDVQKAMLLLYFRASRDYEFLKEAHREVLNSEIDGGIKKLVTRLDGLLSDGIRQPVTMFCQRADYMASENDDGQYELKQVEVNAGAIGCFAIASRFPRLHRRMVSNAGIDASESVMPSDQTDTLVAETLYQAWLEFGNAEAVILFLHGSAHGHLLLESRQIQHQLESIATEGIKCRFLTIKEGGLNRLSLDPDNFSLILDNKYVVAVVFDRIGERVSKEESDLITRTIFRSTAIQTPYAFLALAHTKRMQQVFTRPGMVEKFFNNPEEAHMAEAIRQVQTKAWAIGEDKDVTEDIIKKATENPQKYVLKSNECSSEIAGNFFNEDIPKKLATMAPADRDFFLLTEKLRPMVVKNHFIRPNTEPALNVDATPELGIFGCLIGNMETGKVSYFSRTGHMMKTKLASVEEGSVWKGYSVGDSPYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEN1</accession>
    <name>A0A914IEN1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IEN1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9919.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9919.t1"/>
        <property type="gene ID" value="Gr19_v10_g9919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042164">
        <property type="entry name" value="SLC25A44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314:SF2">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9919.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="56191" checksum="2F3E9D68ED63E1F8" modified="2023-02-22" version="1">MALATSWSVRGLLYPLSVVKSRLQLQKQNNVYSGMRHAFVDIVRNEGMVALYRGFWITLPQLIGTRCIRLGRRMCQHFHSVHFRSHRYHNQHMMIHNNPAKFVGSSQNIAVLDFVRTDCMAKRLTLGLRIIRAVYHVDGIRGFYRGFLSSLMLYIPSSMVFWSVYYNSLALLKRGITRICCYCKHFRVHSVEFNTGPKDKLLGNCAASGAKDDQQRYKFLLNYDWLRSDKTALCDARISWGRCVMSALATRAFPSRAERVRQWMLFSRQWHVIDADRQDIWKLAKKVAKHLSGWWKPIHHPHTDCGDHVVVVNCTDASMHAFDWKHTHFFFDRQYPKSKFDIPAYQIHEYDPCRVVWMCIGRELAFLTRNRIVQRRCYERLHVFPDLEMPDFVRKNINNQLRQVQDVPRKSTEYTSEERAAFPRIFRPDDNFLKDWEEPIEPERWHPHERLKRGEEHINMASDAEIRMAMSRPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEV7</accession>
    <name>A0A914IEV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IEV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9250.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9250.t1"/>
        <property type="gene ID" value="Gr19_v10_g9250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051373">
        <property type="entry name" value="Lin-28_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109">
        <property type="entry name" value="PROTEIN LIN-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109:SF1">
        <property type="entry name" value="PROTEIN LIN-28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9250.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28115" checksum="6EC48DE78FDDB881" modified="2023-02-22" version="1">MASSTPGGSAENSPKRPEEVGMEEELVPDLHTSGGGGEFAPYERREPTEEDIERYKAYVGQKWSGKCKWFNVTKLYGFIVPDVEEAKQHADDVFVHQSELQMPGFRSLDEGEEVEFTVRLGKRGLEAADVCGIGGIALRGHRIHPLGKRKEKEIRCYNCGKYGLHKASHCKRMPQKNVKACYVCHSMAHLASDCPNKEQQQQQHQKNALKAAKSDTKKAIVVIRERALSSEPNLARSGMPKMAYNLVRMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPY4</accession>
    <name>A0A914GPY4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Guanylate cyclase</fullName>
            <ecNumber evidence="4 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4 16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10347.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10347.t1"/>
        <property type="gene ID" value="Gr19_v10_g10347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000050">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF503">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036804490" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="17"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="520"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="22">
        <location>
            <begin position="957"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="702"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1198"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1326"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1586"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="894"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1208"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="1228"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1250"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1643"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="1654"/>
            <end position="1663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10347.t1"/>
        </source>
    </evidence>
    <sequence length="1712" mass="191307" checksum="C71F021156960805" modified="2023-02-22" version="1">MFCGISFLLLRILCFGCCPLLNFCDLVAPNANNVIKVAHLQPNNPNIVNEPQVMEMCYQDMKERRILPSEITLQLITMESCNRLSGVEHAAFLHYLRNASVYFGPGCNNEMNVIGRLASRWNVPIIAHLSGDDALSDRTIFDTLGSVALTSATEMARSTITLLQLYGWKQIGLVKASVNFERLSLHSLKSFLKDSQIEINVEIELDPYMTADEIIATGKLKLLRNRARIIIVEMGMDLHSSRNFMIAVHRSHMKSHDYVYVIPWLAHMHDHYPWEASNIEKQETKSAFDNSIVITAHGYDKKFIEEFELRFNKMTGIISSYYATLSYMSLYDALFLYGLAVRDAVEESPNQSIFLDGRKIWKKMTARQFIGVTGQVLMNNKAIRVPSYATYHVKNGTMRIVVELTARLSDKHKCALSENDCSEHAAHETMSHYWGSYDGYMPNDMPKCGFDGSLCDYTNIYITIGVLAFLAVSIPLGYLFYLKEKERMLYDMNWRIPREQIRLLEERSGTKSGSLHSKTLSHDSSSLGGSLGSATKANARLSAKQAVSNGVKCAHKRYAQMRSLSFNKNELARLKELKVTENENLNKFYGISFNQQNEFIVLWLLCQRGSLEDVLFNEELKISRNFQVSFAKDVVKGMVFLHSSNLRYHGFLCLQNCLVDSNWNVKLTNFVTEEIIGDKMRHNEIKHISVSELIREKKAKESAKKLKNGAGGGKSVDADDDDDSEKGGKRRKRQTAEKKRENTESESRSEEEDVMNERMRDKSNTKRFIQQAPEVIREFISTKNLPTGSQAADMYSLGMVFYQILFKLEPFYERNLPPSKILQKIALASEDDQIIRPSFPNQQQTAATEEAYNLQLLSALEACWLELPEMRPNIKRVKAIVNANLKSTGSGSLVDQMMKMMEDYTTNLEQLVKERTVLLEEAQQQADRLLKNMLPASVADDLKAGRAVPPQLYLGATVLFSDIRGFTRMASSSTPLQVVNFLNDLFSGFDAIIAKHDAYKVETIGDAYMIVSGVPRENGNCHVQHIGDIALKMRSFVTNFKVAHRPDEIMMVRIGFHSGSVAAGVVGLAAPRYCLFGDTVNVASRMESSGVANKIQISESSCNLLKCFYHQFIVTERGKIDIKGKGECTTFFLEGKEQSVPLMMNIGAGRKKGRRHTLTTAKTMFLIAKIVRGRRLLQQLEQEEEKAQKERDKIMAAKAGGGAGGTTLAGRSSRQQQTRQNSQAYEEAGGGRVGGTDGSSTALQHHHSFSEGPSSSSAAVGTGIVGASGRGGIGAGTEHECAAAGSIELNELGTELLMGAAGRGEDVAEKTPFALAAQQQKLMNRSVDGTTQRRQKAVRQRTDSSLPSVDEELFAPTESGQHNVKMRRTSSMPSVVESDSHQKMAFSVSKKGGIHRPIKHYNYEDRLSKLHKRALRFTWQRLQTRNGGKRIEAVFEEVFDRMMRSLPVMREMFNTRTFISAMSRCEIATPRDHARLIVKMFETAIKNLEVEERKRTDTAADFDPNLLGRAHGALRPYGFNSALWEAFGEAVIDVVLNQEAVRDLPGASQAWVVLTACLAQQQQMNGTGGVAPADGTNRQQHQLCRLTSAKSNKTVGESEEAEVPGRGNDERLLVANHHNSNNENRRNTIASCSDSPCTDEEEPTKTTLDRRIDAGGGGGGGTTAGHSQRQRALSMRRRGQQQRCFSVMPDRTGNGQNKLEMKILHDMTSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ37</accession>
    <name>A0A914GQ37_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GQ37"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1030.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1030.t1"/>
        <property type="gene ID" value="Gr19_v10_g1030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF880">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038161130" description="Metalloendopeptidase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="5">
        <location>
            <begin position="62"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1030.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37171" checksum="48025FA60B7942FC" modified="2023-02-22" version="1">MVSNFDGNCTTLFFIIVAIFQHLKGDPMPIDLAEQHGPRNRHGHGDVIELWEENQRDPKMRNALRNNATNRWTTQRDAKDGKFVIPYQISGNFSQSELEVIFMAMQKIARNTCVKFQSKRNRGDEDFVDIQNEYGEGCFTSVGRSPGRNILMLEGTVGETCVTDATVLHELFHKLGLWHEHMRSDRDKFIRVQFRNIPFYLHAQFRTVTTEKAITYGVRYDYRSLMQYGPNAFARPSDALSIKTRKRKFQKVIGTAVDASRGDWIKICAIYRCSECMGHKFDLAKESEQYREEEDGDETTLDEEENGARAAARVQIRLLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRF4</accession>
    <name>A0A914GRF4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GRF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1071.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1071.t1"/>
        <property type="gene ID" value="Gr19_v10_g1071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF67">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1071.t1"/>
        </source>
    </evidence>
    <sequence length="609" mass="68444" checksum="8D76BF1316534279" modified="2023-02-22" version="1">MKCSDEKPPTAEELQNELNELLENVRVLQQLRQQFLHVNNNEMFCGTENERVNLHQLFKWTRSGNLAKCAFCGLKINRSARQKCWHNWNIMRISSDHCTENGLRSFGLYPQHNLAKENICPKTSPKRVGDDYNFKNKRLFKKVHRKGINHFKCFFDDSIRLIPDGNVNDKFINDNNSAHRNQHSFGTSRFSAQLFMGFLTLRKANIMATIMETAGATLVGYNVVDTVRKGIVEIELYTDAPQNLLVGQVAILGGCACWLMLATVFRLPISSTHSIVGATLGFTLLMKGNAGIHWSMVLKIVISWVVSPVLSGTISTIIYMIIDFAVLRRKNPFVCGLRIMPVFYFLCFTFYTFMVVFEGSRVLHLEQIPLWLALLISVGVGLCAMLIYLFILRPKLIIWAKGGKKKECNSSSNLPVDRSQPFNCSPRGVLDWFIPRRERKEDADTLRLFSIVQIVTGCFAGFSHGASDVSHTIAPLVAMLDIYNSQNVLQQGDTPLWMMFYGVSGTCFGFWALGHRVMKTVGKKITEINPCNGFAIEFGMAITVLCASKIGIPISSTHCLIGSVMFVGLIKSGEGVDWRVLTNVAMSWLLTLPLSALFSAFIMPNDFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS21</accession>
    <name>A0A914GS21_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10244.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10244.t1"/>
        <property type="gene ID" value="Gr19_v10_g10244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10244.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19636" checksum="CCCCFCA69E1879E1" modified="2023-02-22" version="1">MCGDLLDGRPLTRSVYVFNNDKEVNLDTSGRSVGGGQVKVEEEMKPLEEDVDEEEEEDESNIYTADYYVQPIANQIRTQRGYTKMLTALFHHSQLFIANYVGWSIGLIIANHQSTTPNNKWVAANVHPRSLRDMLRARSHSQLHLRPPLQLPLGGDDECALKGNDNSVNCKNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS85</accession>
    <name>A0A914GS85_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS85"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10822.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10822.t1"/>
        <property type="gene ID" value="Gr19_v10_g10822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10822.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18121" checksum="6E6F4F22D04B74C0" modified="2023-02-22" version="1">MFGEWMGIEANNNSIESQQKIKVEPREEQFDGDEFALKGIVKVEHEPHYGSVKVEGTVKIKNKAEESGEFKEKLEDRVKEEDQDGQASNTFDHHKKIGDDDKNWEDQDNSKDAKHLSDQNNSTDQGESVDELDSVSFFYGIYYLPFLKPANFIIADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSZ2</accession>
    <name>A0A914GSZ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GPI ethanolamine phosphate transferase 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSZ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10472.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10472.t2"/>
        <property type="gene ID" value="Gr19_v10_g10472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10472.t2"/>
        </source>
    </evidence>
    <sequence length="753" mass="85078" checksum="02C887F4D6657F7D" modified="2023-02-22" version="1">MLVDELVLGSAPLDLGFQVTDIARGLLVKRHVLSHRSSCGDVDANDPQCWTSAHFNKTILLIIDALRFDFVFPAHNGIERMDSPSKYYIGQMPLVAELLKSSNAGLFALVTGAEVVEDNIVDQFISRSRNVTLLGDDTWLQLLPGRFNRHFEGPSFDIKDLDTVDNIVIAHIYDELNRTDWSLMIAHCLGVDHAGHRYGPMHPEMSRKLGQMDELVRNVTEEMPDDAVLFVLGDHGMTQTGDHGADSPAEVSSALFVYSNRLNVMANLSNILTVHQVDLVPTLALLLDVPIPFSSIGLMIDTISFTNRNCKNNFAKSFVNMKTLLTILIRISIFLFLLLDNAEEWITMRLWVFRSALLFLQLSLVFADDPTTDMVIFSLTSLGVSLFSQTMVISYKLFGFFADKNPPFSRSLCLTLFVSLVLSLLPMSNSYIIYESDVLRFFLQSVVCVLMLRKLNEKRPLRYQEIPEELKYAFGFLFITRFLKDFEGCREEQVGCFSDNFEKGTMFLLSVMFALGVIWILLEEHSGRVHILTRAFVWSMAVLLILHWAFELSVVGTVPGIVEYGLSAEVSNLHMNKRFVESVSRRLAQIVYIAFFAHLSIFRWLKDPVTSALAGYPYGLQMALTLILFSMSDPLTSMESVWTSVILLHFIGSIPWHAAFIGLPGNFPFKLLPALLVLCNMFSGKVLASLLVFKREKDNTVEGPFCMLLFVGLRVFGSSMAAFIHHQHLMFFKLQHFYFLVQLAKEEIVGGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT93</accession>
    <name>A0A914GT93_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT93"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10542.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10542.t1"/>
        <property type="gene ID" value="Gr19_v10_g10542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10542.t1"/>
        </source>
    </evidence>
    <sequence length="464" mass="52277" checksum="4E6060AEFDA82321" modified="2023-02-22" version="1">MINPPEQRRKKKQLPTMCAPRRLSVNSIHRARTIVLNKSNPRSRVISRQRAVPVQQQQQSLALPTKIKERLNFDGDHQHVQQQQQPSSSEGGGVGQLQQGVENRMLMDQVHHQQQKQAVDGGGVQQQQQQLDETVMDQVHHQQQKQAVDGGGVQQQQHHLQQDVDDEINVTTCTTTGAFEIVEENTPYPTVTAVRPPRRAAAETAAQRFEQQVKPKRQRAVQQQQQSASSSVAAPPTPPTANVADIEEAMGEQLKSAKSSTTDANGKKKLANREHDTSFKVRIVTPVPQVVQQQKQKRRKEVDEEEEEFEIKALLALFVHSDGERAYYVDWKIARGQECWVIAPDMVACIDAATRLTELTTVSGTLAAILGHDTPHHLLCILEQDAQYHEALVGTNAPARTARDIMFSKDATQRQRTKAIGQLDQFVVDCMSEEAIALYKEKERKKEEKKKQQQQQMNGVEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTZ2</accession>
    <name>A0A914GTZ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Glutamate receptor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTZ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11323.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11323.t1"/>
        <property type="gene ID" value="Gr19_v10_g11323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000189">
        <property type="entry name" value="Glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000241">
        <property type="entry name" value="Glutamate receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037755732" evidence="21">
        <location>
            <begin position="24"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="22">
        <location>
            <begin position="464"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="23">
        <location>
            <begin position="474"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="937"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="711"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="712"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="762"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="84"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="775"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11323.t1"/>
        </source>
    </evidence>
    <sequence length="995" mass="112174" checksum="3CCB32A4BFBD4906" modified="2023-02-22" version="1">MTVTLPPLQFVLLLLHLGVPVDGYPSQIPIESFTNSDDHAAIATLNFTIDRLNSASPGTFLLEHRHKSLRISRENSWDLMSKICGELRSGFMLMMAGVSHQRPYEAYMAVLNGLEVPMINWDLSPRAFYRPNNTNNFEVSIRPPTAPLLADLVLMKGWKQVVYWHDAENADKAAQNLRLVYLHLQRKNESIRSEMLQLPDEVNDFGKFLQTFNLQRFDSNSSVSIITDTANSFRQQRLLQAIRSAQFIQQKYHYVVANFDLQPYDVQMFQQGNINITGFQLIDRESREYALLSRMVELKMKELGESAGLDLETRLAYVHDAVVVAKAALESTLKKNDSLFQRNFRRRGFYNRNFSGIYCHPSTDRENPNRPSGTFEHGKAITAAFSTLSLAGSVDGTLTGRIEFDRDGMRKNFLVSVLDLTSDTKSAFNKKELLFWKHSVGFLKDRTEAQHVRTGQLDSGLKKVLRVVTVRSDPFVMLKRECDPKRGGSENASECEGNSKFEGYCIDLLKLLAEREDFRDINYDIFISQKNQYGAKQQDGSWDGIIGHLLRAEADLSVASLTINQDRERVVDFSKPFLTTGISIMIKKPDKQEFSVFSFMAPLSSEIWMYIIFAYVGVSVVIFLVSRFSPYEWRVEEMASGAFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIESVDDLAKQTKIKYGIQAGGSTAQFFEFSSVQMYQRMWRFMESQVPTVLVSSYDEGIERVRAHKGRYAFMLEATANEYANNRKPCDTMKVGANLNTVGYGIATPFGSEWKDVVNLAVLALQERGELKKLENKWWYHRGQCDKGISDGSSESLNLSKVAGIFYILIGGMIASMLAAFGEFLYRSRIEARKGQISSMKKFRESLGDQLKLSVQGSAIVKEGTVHEMMQKHKADSLLPANYAEPSAFCGGTAASPQKRDGSKQIPPPPSYCANDNNASGAAFRKSAKKRGSSAGGQSHGKRHPYNTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUQ1</accession>
    <name>A0A914GUQ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUQ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11367.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11367.t1"/>
        <property type="gene ID" value="Gr19_v10_g11367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF428">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11367.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="36059" checksum="FCEF61977796BB23" modified="2023-02-22" version="1">MAERSRKGGNGKVRKCLDGAASETDGRRGDVTTKDDVASGNGQSAAAVIVVMPLHQTMANPKFVSQIRLAAFRDQLISEADRIRFLAIGTIALGTVSLVIAVLLIPFLFLQSQKVHFDSQDQRAFCRYRSNIFMREVNHQEHLAGRNRRNVPGGNCCSCGRGPIGAAGSPGEPGEDGHNGTPGIPGEPGPPSPQPPLPQYDWCFECPPGPSGPEGDAGPQGRPGLLGLLGQPGRQGFRSTRGESGDRGPPGPSGPPGHKGPLGRPGHINEIPGPPGPPGTSGPQGPKGPLGKPGRIGFPGRPGTRGLIGDLGERGLKGGSGNDGETGPDGTPGAEAGCDHCPPPRTEDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVQ2</accession>
    <name>A0A914GVQ2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Endoribonuclease MBLAC1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end 5'-phospho-ribonucleoside-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68096"/>
            <dbReference type="Rhea" id="RHEA-COMP:15179"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="Rhea" id="RHEA-COMP:17428"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:68097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GVQ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11625.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11625.t1"/>
        <property type="gene ID" value="Gr19_v10_g11625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07711">
        <property type="entry name" value="MBLAC1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF48">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="8">
        <location>
            <begin position="370"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11625.t1"/>
        </source>
    </evidence>
    <sequence length="547" mass="59975" checksum="96F57A640C7B160A" modified="2023-02-22" version="1">MFMPLLYAAAPQILSDLNFGVNVTSPQFRHRLRDFIGRSGATTSSSRRGKGSISRLAIDGTDPLQLPDPDMNTMDDVLLNEDDKLTRMDAPNFQPFQIVMPSNVRKTEHNYFVAPAKNSSIVEAPDKMPEDYEKLAKFLQRFVSLQQNKKILNQNSMNITPKMQNLSKQTPAAEGGGIGDEHHAKFKFGNAASTNSAARGTVIGTVPVSVDIGHDDGMEQSSFVPNGNILPADEMKPPHSKAMDKAYKLEQKGQEKGTDSVRSWDGRVEKVTTLKMTPSSASAAVTASASASADDNANIGQPVQKQQLLGRIMVATNKNNSAAGNMEREEEDQSFFYQVPNKNGNIDNAIVEILREGFARQLDDTEYVFVASITLISDGGKTILVDTGMGTDINGRTDLIKKLSQRNIAPPAVNYVVITHGHPDHSGNTNDFPDAIHFQGVMSHYRTKFNFTDLFENAKHQLTKNVALFSTPGHTSEDISVVVKNAHGYGTVVVSGDVFITEQNRRIILCMADFVVPGHGQMFRVSAKVKRRANCSNLSDLQHTEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW48</accession>
    <name>A0A914GW48_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW48"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11313.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11313.t1"/>
        <property type="gene ID" value="Gr19_v10_g11313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11313.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14171" checksum="C2C7F8DE6024BC3F" modified="2023-02-22" version="1">MRLDFLERALSRCFSAHIRIVTLRPAPFLLLPLISSALLSIGLLRLLDALVKDELELYTSTDARARGELRELATLFHINDTDLFYASRRYDLRRMGYIIVTGVDGEILNSTTLKVAHHRSRRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXF1</accession>
    <name>A0A914GXF1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SUEL-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXF1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12055.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12055.t1"/>
        <property type="gene ID" value="Gr19_v10_g12055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22828">
        <property type="entry name" value="Gal_Rha_Lectin_EVA1_EVA1C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22829">
        <property type="entry name" value="Gal_Rha_Lectin_EVA1_EVA1C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036812139" evidence="3">
        <location>
            <begin position="31"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="62"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="187"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12055.t1"/>
        </source>
    </evidence>
    <sequence length="635" mass="70726" checksum="C33DA9932DB1A17B" modified="2023-02-22" version="1">MRSIYPPITAIPFLLLFITILPCPCSVTLQETSPELLEEIVRTVRLHHSLLAESLRLKHVKACEGERVTLHCPRNTHISLQTIFYGRLVPSQELCPSPNDGGRAQQTVHASSSSSSSSSRARPPVEDTSCDFAEAHSRVQELCRNKKKCRLLVRPEFFGDRDPCPGTSKYLQIGYKCSPIKFEDQNFCEGQQTQLGCKPGRRLSIYSANYGRTTNGQAMHCSTTKRQQNDDEQKKNGETDDDDGDDGEGKLVREDCVSDVLPQLVRRCHAQPSCSLPVDDRFLGSPCPVGVSKYLSVIFVCVNEEVFSEAALRGRLEKMAELEKELNKLRHNNRSAPPQRQSHATPSARHFHHPLMLRHPMSGEEWEGEEEDRESVDYGIEEEEAAEAKGKREEAEERRKGVPKRASSEANKSFWQMLLNHLNAEGTDHALFVGLLLLSLVVILALSLCVLILCQHRLRERAKRHNERQNRRRTLDQEFQRQNSVLAASGGKRAGKEKGPRGAKCELGFLLSAAESSNASPVYVDSSDGSNHRLLDAAAFAPPLPPPLTSAADIYHECYLPCGSFSSGGGGYYGRFDEQQQRLGTAQSGQSSARKVSSTQLINGKCAAVTRWEMNNLSDQALGMLDRSLTKDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY26</accession>
    <name>A0A914GY26_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenosine kinase</fullName>
            <shortName evidence="13">AK</shortName>
            <ecNumber evidence="3 13">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="3 13"/>
    <dbReference type="AlphaFoldDB" id="A0A914GY26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12395.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12395.t1"/>
        <property type="gene ID" value="Gr19_v10_g12395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000076">
        <property type="entry name" value="Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 13" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="66"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12395.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38212" checksum="E3DDC53C8A1C3BF4" modified="2023-02-22" version="1">MDNGVGNKTGNDYVLLGMGNPLLDLQVATSDTQLHKKYGLAENGADLINSENSAKLLPIFEDIFLLGEKIDFVPGGSAQNTVRVCQWMIKTFGAKARSCYFFGAVGKDKFGEILHEKAQAADIETRYQEVPNEKSGTCAVLVFGGKSAAANQSLIEQISNFYVEGYFLTVSLDSILCLATHAAASDQTKHFALNLSAEYICQFFGDQLEKVLPFVDILFGNEQEAMAYAKTQGFVVEKEEDVGEIALHLCQKEKVNREKKRIVVITQGHLPVLVAHDGKLEQFPVESIPESQIVDTNGAGDAFCGGFLAAFSTGRAMDLCVRAGNFAARTVIQHVGCTLPTECDYSEQNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZA5</accession>
    <name>A0A914GZA5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZA5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12172.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12172.t2"/>
        <property type="gene ID" value="Gr19_v10_g12172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040271">
        <property type="entry name" value="T19C3.2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37443">
        <property type="entry name" value="PROTEIN CBG09852-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37443:SF2">
        <property type="entry name" value="PROTEIN CBG15264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037041613" evidence="2">
        <location>
            <begin position="26"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12172.t2"/>
        </source>
    </evidence>
    <sequence length="281" mass="31420" checksum="D20F041937E14E73" modified="2023-02-22" version="1">MKTVTFVQCIWPLILPLSISSECRALSFGPLNFLIATFLDAQLVTILGNANRAENCAEWTDWGPCIWLRGDNNARWGRSFFDQLLPGRTGCRSHMFFKLLRERWGQHKYTAFENVVDYLREMTLSSAQCGQCSYQQSCGRRCHRRVSANSVVNPLFVAERRCEGVDQSVSCVSRPTAAGDCKLWPNRAIALPNVSDWMVAMIHSVQFLNCVPQTTANGVRLCRCCCAPFIARPEAPFHCEMPKEEAAKDDDAKHSIPIASPTEANASSDYAIPSQNAFFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZX1</accession>
    <name>A0A914GZX1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 8"/>
    <dbReference type="AlphaFoldDB" id="A0A914GZX1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12906.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12906.t1"/>
        <property type="gene ID" value="Gr19_v10_g12906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106279">
        <property type="term" value="P:negative regulation of UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000023">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="79"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12906.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="46434" checksum="D61E53219D4F78E8" modified="2023-02-22" version="1">MLRKPTSKICFRDDELWRQQPPGTIICFRNCRLFRNGTFGSDSDDELWVRDGKVLDHQRIFYGERKRPNLWVDCGGLTLAPGFVDIQMNGAFGVDFTSMAQMGDGKKALEELEEVALKILAFGVTAFCPTIITTRPEAYKMFLKVLNEYNSTRGARILGAHFEGPFISPIRVGCHPKSLVIASLQDNSLDSVYGHDLSKLSYVTIAPELPGAIETIAFFCQKGIEVAIGHSDASYEEAQKAVAAGAKNITHLFNAMRPMGHRGDPGIFGLLAMCNIQPVYYGLIADGIHVNELAIQMAFNANPSGAILVTDGIAALGQGNGRHSLGNVSVRVEGHVAKVDGTETLAGSVSSMPHCVLTFSKVLNKISNKCSGLVEALKAASFNPANFLGIATEMGTLKEGSNADFVLIDDQLNVFATFIGAIKCHQSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H196</accession>
    <name>A0A914H196_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EXPERA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H196"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13225.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13225.t1"/>
        <property type="gene ID" value="Gr19_v10_g13225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13225.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28856" checksum="19DFB3CE8061EB07" modified="2023-02-22" version="1">MAFGVLPNWIKIWLVCSTLICSADVAFTTLRPESLRDGNYGKFFTLWNIYAGVDTRYANETDPMTRVTGPLMCVELVLNLIALFTDFVGSAHSLMAAFLSSSLVFWKTTIYLCLFLVPIEERYGCLQYGNNSQLSHRGIASQTPFWKELLVFWTPNSVWVFIPLLAVLQLWRQIARGWTQPSPEAVADLAFENCRKTFVNELRELCALDELDPAAGKEWIDFHCVAIVFQSWPMRERRRRGEEAAGDTHISTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1I1</accession>
    <name>A0A914H1I1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1I1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13056.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13056.t1"/>
        <property type="gene ID" value="Gr19_v10_g13056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13056.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23188" checksum="6CFE179969F9E9FD" modified="2023-02-22" version="1">MHYSYRVTARRYGLKTMRAKVNPAVNDAKMGWRNGLAQSDVDVLNRMYCTAPDCVDKEICCGMWALQNKCYKKGSRDARMAKECPKSGGFCKPILDEMQEMFPSIQKEMIRMVLEANGGNKDSTSNALIDGQPREESGSGSGRTEGDVPQHSEGDDPSEKNLEAALDELKEMFPSIQKEMLRRMLEANGGDNDSTADALFYNFNTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2M6</accession>
    <name>A0A914H2M6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2M6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13305.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13305.t1"/>
        <property type="gene ID" value="Gr19_v10_g13305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF40">
        <property type="entry name" value="AGAP006757-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13305.t1"/>
        </source>
    </evidence>
    <sequence length="307" mass="33285" checksum="1CA166C9CB3259AC" modified="2023-02-22" version="1">MTSVIPEIAFPISQKNSDGEIVASTSFGDDGALEMEFANDRQLPSPPYSLTQLSQGHHVNLQDKSGKSLLIHSCVRGLKSTVEELSLDENIDVNLEDSEGNTALIHAAQAGYTQIVELLIDRFDKLEIDHVNKLGQTALIKAAIQGRANCARILLRAGADPYRRDNGRQLTALEWAKFVGRTECGRLIGEFVAPRRSGGKQSLQNSAQDNFKQVACLAVIPLIGGGVRELPALSRPRLRSAPPTPAVKIRITPPSSPFCQALSTAPTAAEGHPPKQFPFKAIAKQNHCLSSKKRPLRTPERAKSSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3H6</accession>
    <name>A0A914H3H6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3H6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12923.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12923.t1"/>
        <property type="gene ID" value="Gr19_v10_g12923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mammalian shaker kv1.2 potassium channel- beta subunit complex"/>
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    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
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        <property type="entry name" value="KVCHANNEL"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
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    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
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            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
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            <begin position="156"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF02214"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12923.t1"/>
        </source>
    </evidence>
    <sequence length="607" mass="67838" checksum="A096D8798BDF1C4E" modified="2023-02-22" version="1">MSCVSGVSATSMLRPVNGNMIAAAQQQHRKRRQMAIRKTDSMNLAERHNGRILDLIWCEGDAQSFNKAIRSKASVVSCHATFASGHRSSCGSSKKDSSENLLMAPSSTTLIPSLLEQVPEEEDELLGKMEGDVEEEEEEDEAAEQGDGDNSEEVLLRLNIGGSPFLILVDAILRADPTTFLAKFVQLNHQSRLKVTDSYLQTECAYYFQRSPLAFEPVLQYYATGVVHKPPEACPSAFNAELEFWRISTSYIGACCAESVSPLERLLESSKEEKVDDISFDKLCCGRLRRRMWTFLERPGSSLQAKTFELCSTLFVLISVLGLSFGTIPDFQVTEYIPTGNRSVINSNGTSIEREEFEAVRVEHPALFAAPRKLRFALKPLNLVDLLAILPFYLELMLTMFGVDDKKLRDLRWAFLVVRILRVLRVIRIIKLGRFSSGLQTFGMTLQRSQKQLQMMAIVLLTGVVFFSTMIYFLEKDEISTPFVSIPAAYWWCIVTMTTVGYGDVVPATTMGKVIASAAIMSGVLVLALPITIIVDNFIKVAQEEQQTEQFKAELLAMEDQERQQAQEQQKWREKIDKCNGGDNSRARGYGSGDNRGFGGQQLLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4K3</accession>
    <name>A0A914H4K3_GLORO</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4K3"/>
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        <property type="protein sequence ID" value="Gr19_v10_g1378.t2"/>
        <property type="gene ID" value="Gr19_v10_g1378"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1378.t2"/>
        </source>
    </evidence>
    <sequence length="698" mass="75878" checksum="6B912B0DE0708781" modified="2023-02-22" version="1">MLCASISCNFKLLSLKIVLIILTAKFGNSFLFYSGNPGQLCCCINHLNLRPTNGGLYKGHQPTAGGTINAAAAETTLWRPFCKFSADSERLLTGEFNEADELKVPSKNGPPKLVAAAAKAILVQLPALLVQRQEAASTECGQYQNSENDRKTEEEKESAGEEEETERGRNEEEEEEREGQPGKESASDKREQKVAMDDGPCGSNNINNKQYPRRCCCECAKNCDSCYECSNNKDGVAIDAQKVPLKLFKPFFAKKANFGVFNSPPKQQIDFVNKASEKRRSSVDESFENLKQRLGEISHKLDFWKTNLLRKPEEEGERFSTDRQQSNRADQLNMLKAVINKELSAISVTESLTKTILENGDADKDGGRGYNYNSTAQTEALLTSRTLPASTSTSPSTITTTTRSSLTTQQKIVTVITKEVPTTTITTTTTMPTMIGQNVKNVTTDLLPGNGAGGHPQILQGPPTQRAAPPPVRRVTEKPSPSPPPPSTLSPPQLELPTPPPYTAPNVPATSVVNTEVATAINGGTTTTPSSSAQTTKLIIVSQRQQNADDINNEINVISPSVMPTTISTASTTTAAVLIDVKQSAGLTTDSNSSNMTTILLATTTSSTNAKMFDEGKGTTAEKENNATMELFVDRMQFDENNLLEQIHNVNLEDPQITTNGRPISLVSSNFASKNTKESKHQISQFNEHLPPRETHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5I6</accession>
    <name>A0A914H5I6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5I6"/>
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        <property type="protein sequence ID" value="Gr19_v10_g14014.t1"/>
        <property type="gene ID" value="Gr19_v10_g14014"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF317">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="148"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="333"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="605"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14014.t1"/>
        </source>
    </evidence>
    <sequence length="693" mass="79250" checksum="59885C01A01429CD" modified="2023-02-22" version="1">MRLRMRFNKERQMRLRAFINRQSKKATSVAVHICMILGVTLYTIFGALIMQRIESNQIQNHKLQQQHQHSMGKRMVAMHDVQKHRLRHVRRIDHKNDCLGPIIKALRHSHCNDSALRQLDHCYGFLTEQRQVQREETRNLDEKQPTRYGWSFTDSVLFCFTVITTIGYGNVAPKTFLGQMFCILYALIGIPFTLLAIADLGKFLSEILDGWERTCRSAKKEVQRFWRNFRVQPKKFSFVSLLNAQTSYIIDPNNNNASSFMERLQIFRGNKSNATTPVTDNNPLVETLLDKAEKGEVCADRNSKMEMEEEEENANDEEIQQPFERTQTIPLLIMFIFYVFTGAFLLSAYEPDMHFFKAIYFNFVSLTSIGLGDVVPQSETYMAFTLMYIAIGLALTTIAVEIAADYLKKLHYFGRKIENVGNVAIWFGSKRLTVKQLVKNLGDQFNLPVHQIKTLDLDNFVDNAIKVEQGELETLRAPPFEPPKEEELDYADDEPIIEWEPQKTPSTSTEHEEQPPSEPEPEEPEPEPEPEPPEPEPEPEPEPEPEPEEPEVEELAIDLTGMDEQSLQAPTSIEQSTPSSERRKSNYSDEAWRRYLEYQKQWKKFRHTQTSGASSIVEHTTPKSPSTSSPRAKSAMDNSSSKASTSARGTQKLSSAALREQSAIPLRQKKTSRTSTESASSGQKKSTNRGAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5P4</accession>
    <name>A0A914H5P4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysophospholipid acyltransferase 5</fullName>
            <ecNumber evidence="16">2.3.1.23</ecNumber>
            <ecNumber evidence="17">2.3.1.n6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.23" evidence="16"/>
    <dbReference type="EC" id="2.3.1.n6" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A914H5P4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13911.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13911.t1"/>
        <property type="gene ID" value="Gr19_v10_g13911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF14">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13911.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="55068" checksum="E9FC79B2D2F3F611" modified="2023-02-22" version="1">MLGIVADYVNVREDAFRLILSILAGYPLAFVHRTFLFNKPAFVQHSYFTFVGILLYLFNCGIQIYHSLVSIGIAYLIITFLPGTILSVFFAHFCFLGHLLIGYWFAESSTYDITWTTPFCIMTLRYIGLVMDIYDGHQTTTDKNAAAKTARAARKNDADFVGNTAISERPGLLEIAAFGLFFAGTLVGPQFSLARFRAFVNGQFLDENSEVRQSSWMASIQRFAAGIFYVVIHSWGTLWVPDSYLNSKEFMHLPFFWKVVWNTIWFRAVMYRYVLCWLLTEGVTILIGIAYNGTDENGDDRWDGVRDIHIVKFELGSDYQSVIDSFNCGTNNFAKNHIFKRLRWLGNKFVSHFATLFYLALWHGYHLGYFMLFIHEFACMAAQEQLYEFIERGPPAVRQLLSRWWMRPLCWLFGRVAITTSMAFAFLTFGLVKKEIWIAPMIAMYFYGYVLYIVLWPALFYLVLRPMIIREGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5Z2</accession>
    <name>A0A914H5Z2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5Z2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14493.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14493.t1"/>
        <property type="gene ID" value="Gr19_v10_g14493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14493.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9758" checksum="4439BD94DB4D54C9" modified="2023-02-22" version="1">MSNNSRGANGGGNTRKTSSSIFIAVRRGGRLPFKAIGKHRPKCLVLCLRSPSSSRFPPFFQTFSAHYSLNGTTNKKSRSKSLPSTTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7B6</accession>
    <name>A0A914H7B6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7B6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1468.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1468.t1"/>
        <property type="gene ID" value="Gr19_v10_g1468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1468.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9139" checksum="02DA9479D7496EB4" modified="2023-02-22" version="1">MGEVRRRRQKILQKSTSAGVGRTGALVSIDYVLNQMLDLGIADVFRSSPKCVSSEIWWSSQWASTCSSAKHLRSFNCSETQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7C2</accession>
    <name>A0A914H7C2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alkaline ceramidase</fullName>
            <ecNumber evidence="9">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914H7C2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13890.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13890.t1"/>
        <property type="gene ID" value="Gr19_v10_g13890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46139">
        <property type="entry name" value="ALKALINE CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46139:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13890.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32103" checksum="122D0B40D9A8E685" modified="2023-02-22" version="1">MERWFAYETGMPWCESQSDNKYKIVPFVAEFANTVSNLPLVLFPLLNVFQLWPYLSRVNPLAIWPHALLALNGMASAYYHATLSLFGQLMDELLLLHMINTCLIAYMPVLDRVVPPKLQAYQRHIRLAIVLLSVMVSVLCFIKPAVNAFVLITFSLPAAFLVYFEGTRNGIPEAPNLINRIMLSWTMAIACWLADRLICELWLQLGTPYLHAVWHFLAAYAGYNVFVMFSLLDIKKRSAIKQHGFSTSIRYFPSPQGLTKDGPPFLTFPYLVLMDSSAKCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8W3</accession>
    <name>A0A914H8W3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15289.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15289.t1"/>
        <property type="gene ID" value="Gr19_v10_g15289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="10">
        <location>
            <begin position="606"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="10">
        <location>
            <begin position="1170"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15289.t1"/>
        </source>
    </evidence>
    <sequence length="1477" mass="168719" checksum="F8496C347CB3677F" modified="2023-02-22" version="1">MAALPDGDLPPILDGPFSPTMDADALLEEAPPLEAVLERLHHEEIVPAQPKAAVRAQRKEPAVNKQLGAEQFNGEHWMCLAAAQACSGRFKAFRFLGRFMLNFIWGSAYPEDVLKALFAMTLAYAVQGADGMNIVADHFIFLLSARHLDYEIALHFKKIDNTTTETILTRFEMVDQSNKSKERPSICEESFVIDITAIDSGGKRKKLAGKGRPKEFSINYNIHQGATFELTNSDNFCLFRAFEFLRMKFVLPQQRFSEYKRAPAKQLNDVHALCNACNIDLAQPFYSVEEYGERIQAFYNQLHPGMFRLFCFETSGKMKPSWKSDVDDYQHELCVLFTEGDEGAAGHYDAIKAPGRLFNQKGNYCFGTFKCVECYEHHAKITIRKTKRGKETTTTQNAICKSSKKCIDCGVIYLAMDQDKQKGHQCGQKFCRVCLGFHAPRDCYIPYRPKEKKDKRLIFFDFECTTDFKPDPELARFKHLVNFCYAHVTCTRCIEKGIWDKELEKACAICGPLRFYSWAPFYYDNTEVDRAFRVDDPLAAFTKWLLHFEAETLGLDTNERRKRKRAPAKNNLLDEEADDVDSDDDDANWMIFGEKGEKPVSVTTYAYAHAGSRYDHVLVYGEMLRMGVRPNLVRQGNHLLELRAPKKGGITATVFRDSYKLIPLKLAAFVKTFGLEIDGVENKKYFPHKFNKEENYDNALDTLPPLEMYYPGGHFPEERKKLERWHRENFNTPFLLREVIADYCKTDVQILAHGVIKMRELFYNETRHDITDSVTIPSACMKVFVTLAHYDKQKIAIIPHLGYEKRGKQSSIARKYLKWRAEEEMRENGLTLRHVESPGGEYKFGNFSLDGMLERPGEGNNLAIEVNGCFWHACPHCFPDDAAIVAGGETAGAIRARDAKRIAQIAREFEVEIVWECHLNRLLDDTPAMKAFFDNTPDSGPIDFHDAFFGGRTGPEWLGASVILESGELLPRTIKIKDFNSLYPSRNMFTNYPVGHPTLLHFDKDVHWCKPADMKGDDGYPLEGIIKCFVVPPRHVHCGIPVLPLRMNKRTLFPLCRKCSELFPNGALDRVYSCPHFEDEDRGFSVTIPHIELAEALKVGYRVTRVYRAYNWPLASDWSGFLFHSYLEKFLKMKFEASGYPANCSEEGISEEEAAARKQAYINKAFSVCQVRLNPDNIKYNPGLRYVSKLCLNSLWGRFALRNRLTKTEIIDNHADLAKLLNDDKIDISSIDQLTEKFWMVCYKAKDEHVVEHDTSNVALALWTTSAARIHLLDSLCKVFGAANGPGRTDTRVLYMDTDSIFYEYETALGDPLPGGEQLGELTDEYPAHTIVEFICAGPKAYALWLRDNNTGEDQYKMKLRGITLDSDACQQINYAKMKEMVLEKWGAQDNFVSFNYPTKNFRITKKGDIFTVPLAKRFNPTVNKGVIRDHGVRVVPFGYTDWEYCQLNNPHCCECQVFVPDPEYNFDIADLAPESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H919</accession>
    <name>A0A914H919_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H919"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14896.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14896.t1"/>
        <property type="gene ID" value="Gr19_v10_g14896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14896.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12102" checksum="5EAC4CBF0A8ABE62" modified="2023-02-22" version="1">MYTLNAGGRFSLCNFGLSQTLITDNPSELGAFLDNGKIEVTGLDILTPERILISYHQKKDWVEEHPCSNLVISLFTTSAARLHLLKSMQKVVRTPGCQLLYTDMMPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9H0</accession>
    <name>A0A914H9H0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9H0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15279.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15279.t1"/>
        <property type="gene ID" value="Gr19_v10_g15279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15279.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13215" checksum="EC13AE45D4D704C5" modified="2023-02-22" version="1">MEFLEDDGRPPMLDGPFTPARNESMAETNYSDTSKDFRLADCLPILESVARAYDCIYPLPKLGRDHHMRGCLLIRSLASANRLYIFEWEECLELKGHLEMEDGSSKRVLHKFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA00</accession>
    <name>A0A914HA00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HA00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15166.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15166.t1"/>
        <property type="gene ID" value="Gr19_v10_g15166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15166.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19833" checksum="08D362B91243DD5A" modified="2023-02-22" version="1">MTKQVLPERQQTHGDFNPFHSQVPIYAKANNTSMMFADKVKVLANLTMHLRDCLQANNAKPSCFLVKSIHEKNLANDFVRCIWKIPLHETQGIDTVDTLLRLLEGMMSKIGAREGEEYTGEGMAHHQEQGVHEGAMENGHFLHSHLVADDDLEEMDDDDALMHDKLTKLAKKTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB12</accession>
    <name>A0A914HB12_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ku domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HB12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15867.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15867.t1"/>
        <property type="gene ID" value="Gr19_v10_g15867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="13">
        <location>
            <begin position="317"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15867.t1"/>
        </source>
    </evidence>
    <sequence length="602" mass="68115" checksum="B811A92DDD4CD0CA" modified="2023-02-22" version="1">MEKTDETFQQWQEEQPGIVYDGGKKGRLFVINYGTEMFAGTGYCFRMALQAVRNQISDICCMGDSGELCAVMFANTERTNDKAENIDNMFLFREMGTVDAELVKELDNVLCQDGSRLSLDPLVGGSGVCNWAELLYLCHKLLRYGHQFRKKFIHIFTTDQERMSAKTMGQVRSRLDEINNGGIDVSVFLMDDPNIPQEEQNRVGVMTDFWAEVDPMLSRFSSPAELQSGLRLKNYALRSTTSLPFKMGDNFEFAVGLYYLIKTQAKPSAIMMDAETGERVEQRVHYLPTAAGEEKAQSAPSSEANEAEAPLLPGMMAGELFEGELGFKRHVGGVEVVLKREELEKLRRLDRPGIVVIGFKPLRLLKDSHRMGPAVFVYPIESVISGSSAVYRALLKRCLDKKLFILVRYTHKTNTPPKICALVPQSVDQIPSGCTLAREYFYDGFHLVELPFAERARSMEKRFQPPDGGLGKWPSASLEQVEAAKHFVKKLINTKFSPDDFANPVLQQHYKAVEIVALDLPFDSDQFKREAAENDKLMPYFKNAAFEHRVTTELENFERICSSTEEETEKKRRRKELPQEERGAAGGGGKSRRQRLPRVNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB43</accession>
    <name>A0A914HB43_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB43"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15436.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15436.t1"/>
        <property type="gene ID" value="Gr19_v10_g15436"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g15439.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15439.t1"/>
        <property type="gene ID" value="Gr19_v10_g15439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15436.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15439.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40884" checksum="066E9740E2E5DB92" modified="2023-02-22" version="1">MSDNAKKVEKQLKEIRISADVLFEVFKFCRPRMLGLKVALISDRFDRLVDEHFNLNEWSLGNLEIRRGKKEKDDAQIVKFVDGKVERRLPIPRKSLPGKVIGFERLKISYIDRNVIEFLQRIRRLFDSKKASLSIKTFDNQNRSWEIIWKKIWPLISASIFQLSLNPFDLDCWRKFFPTILDDCPKLHMIDYHSGVPKFPGDDSAGAFSEQVMAKWLHTPREDGLPKVLRCVYFMGAMEGVKNAFLNSFEQANFIIRLGHWGCFYWIVPFDVKNNLTGERLVFRRFNKEFSLLVRCPIERDEDKWAKWEKEAVEWLWNCVDINFEDNDIGDGRRKRRARGSKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB55</accession>
    <name>A0A914HB55_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB55"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15738.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15738.t1"/>
        <property type="gene ID" value="Gr19_v10_g15738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037599103" evidence="2">
        <location>
            <begin position="27"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15738.t1"/>
        </source>
    </evidence>
    <sequence length="642" mass="70744" checksum="BA5241B9C92A5FAF" modified="2023-02-22" version="1">MILPFTTFKWLLIVSIIGCFTEMVAVEEVTEQVQPVAAPNTASALAQPPEGLQQARPLSEQNLEQQQQQQQNQHNFEGAIGNESALGSAGGRALAAPLLRGQQQTQAENAVEVNGERKPFFKIHYRDGVQKAVFDETPRRVPADFEDTNSVATGGDFDAYDDSRLVDPQLEQPLFIPEIYRNETREETKTGPPKGKGGTNRPLVSPELQSRQPITIRTTTARPGAVTAPPPIPFVRPAQPFGPPPASPVSPQRPKAPPASVLNQPQASRPLPQPPLPQQPFRPPNSQPPLQPPRPPPTPNAARPPTPNQQQRPLTPNAGGAQLRNGMCHQAIFYTPQTVTELDLQRVYTHFALVVSIDQCARTCHEFNCDVAILDPISRHCQFNPSTAFRLHPACPQWPNPLYRNNVRLGQDHIRIACVTCQQRRRIPRPGQNSPMPFNGQGKQQQQTSSVRRPATGGAPPPPQHVIRTTGRDRLNAGPALLNGENSPLRIANAAALLQAAGISDDNEAGRDLSAEFHKLERLLKSAEDYLDDSEPQGERQLPADGGRTKPTVGKEVPSWQEGHPQGEGFSPLRINPLRRPYMEDPSRPHAIFYSTDNMQRQKVAGSERKSEHRQDEFVQRRVRRDGAAGRGERPPAMALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBB9</accession>
    <name>A0A914HBB9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sulfite oxidase</fullName>
            <ecNumber evidence="7">1.8.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.1" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914HBB9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15948.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15948.t1"/>
        <property type="gene ID" value="Gr19_v10_g15948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="504"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="575"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15948.t1"/>
        </source>
    </evidence>
    <sequence length="805" mass="91055" checksum="C86B437BEFE804EF" modified="2023-02-22" version="1">MKYFTKHSELLRILRLATSKNISSYGYTKVLETRWTNAVVKRFVYMAIAGGSLGFAFHQFKRGTTSGGIIAQFYGPANAERIWVTFKQGVYDITDFIALHPGGDKILLAAGASIEPFWAVYAQHETEEVTLEEQRKKVPSDDPFAADPPRHPALIVNMQKPFNAESPPDLLTESFLTPNQLFFVRNHMSVPETHEQTHCVRIDGIGVDKQIVLSVDDLRNKFEPVTIISAIQCAGNRRYDMNQSKKVQGLMWTGTAISNAKWKGCRLRDVLIAAGVKPNDKRIKHVQFEGADVDTSGAHYGASIPFEKAMNPEVVLAFEMNDEALTRDHGFPIRLIVPGNVGARQVKWLNGIRLSDEESFSNWQRRDYKAFPNSVQIGDPLPFDTTPSIQEYPVQSAICVPNANSKISPDAKTVTIRGYAWSGGGRGIIRVEVSSDSGTTWKCAELEQCSEQDLEHMWAWTLWSVELPIPEAAIEKARNRGRTLECPRIIAQRMAQSYSACGMNKSAERGRKLIEDRLYLYCTIENAPQFLIDAKIGRVLTVAVDHIGQRRRLPGVEYRHIRMSDIETEELLASQKLLWALTYIEDSVNNGINIVVHCQCGISRSATVVVAYLMRKHSWSVHEALTYVQKRRSIVQPNPSFMRQLEIFEQLGYRCDSSFLRQSKLFKEFQSVTNNPLNVSIDGDVYTLNESAKYSVGGKRFSCKKCRSDLFFDFNVLTHKIDNKSVRNVGKCGLIYLITPMEWMELNEHSGKLICFKCHKKIGHYNWSGKECLFQFNGNGCGAYITPWIHVHAAKIDSFEMKIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBK7</accession>
    <name>A0A914HBK7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBK7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15567.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15567.t1"/>
        <property type="gene ID" value="Gr19_v10_g15567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15567.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9742" checksum="D1825ACB28346097" modified="2023-02-22" version="1">MSCRSIQKANFLGMNCAAYIVALRARNAQFAFPTSRLLDLVRLGGAEAFAARQKRSMVELLRAGRAQFGEKNTGRRQKLIHQNNNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBY6</accession>
    <name>A0A914HBY6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBY6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15698.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15698.t1"/>
        <property type="gene ID" value="Gr19_v10_g15698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="11">
        <location>
            <begin position="166"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15698.t1"/>
        </source>
    </evidence>
    <sequence length="823" mass="93495" checksum="2A70CA5B13BBDA97" modified="2023-02-22" version="1">MKKPEQINEIRTELQMARQEEEEILARIKDELRKTEKHLGTGNFQRLFDQSVARINAEFERVESNARQLANSLDSVSGLAQNISCRVAALDLGKSRVVECLQRVNDLRDLGTCASGVQEAIRADKYEEAARHIHRFLTLDTAVFKMGDHRESKDAGYSVKNCYEILRNATNELKRIIEQRFDEARTAGDVASMERFFKLFPLINEHNSGLQRFGAHLCNQIEALGEQNYRIMQAGGTDDKRKNVLYADTLTMIFEGIARIIELHQPIIESSYGPDKLLTLIEMIQPECDKQCGRVMSAFIQRRHFEEKARQVSSLTDCVRPTVTAASQTQQSSAAGVDAIELDLLLSEVTLMHTRAELFWRFLRRRLCRPPIETVDKTLDESQNQREKSAVERRMVEEAEPLEAPDEATDEFEDEQQRRGHVERMRKQREEHAMKLDAVLNRSGLSTKMQELLGKYVLIEQFYMTQSVRKAIDMDDVEEGALTSSLLDDVFFVVRKSIRRSISSSSVDCVCAMLNNGATLLETEFLKYISTPIKSGYPSTGWSAESAYQTAQNVMHGKGEVVGGLERQRSVFLTTLNNLRSSIECVNTLKSGLSGDFHKNLAQISANDNKKLDNAMSQFDDFARRLEQHANLGIGKLCEAMFRPKLKSAAEAFLEIPHSLNDDQLAEFELNDPFMSQFVVQLDRLVAQFEALLVPDNYQMLLVSMSTECVQQLERVVFKCTFNRLGALQLDKEFRELSSYLTSLAGWNVREKCTRLSQMIALLNTESLDEAVEFIQHLQETSHSSTGVLPGVSISLNDVRRTLHLRSDFSREQISAKLKILKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCP1</accession>
    <name>A0A914HCP1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCP1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15396.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15396.t1"/>
        <property type="gene ID" value="Gr19_v10_g15396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15396.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34225" checksum="D86960AE4F74ED23" modified="2023-02-22" version="1">MPNDGKQKKKVLCGVIVMGLCRTITEFVAFVCEIDNCRHQSYLSSSPCPQCKAQLSASEASLTAHQILKIVEETHQTLDVTQHKVNETFALVNGAYRLVNALVEVNRKLDEMKPLIDKTNQDLSGMIRKKEERNRCDAEVKCARCGGLYACVEQYRWTKNVDGCCPTGYRTTCCETSTTTTTTATTTTTNERLTCRKAVWELHPDGIKKYENPDKFCGQADRHCYVLNCTVRHSIPFDWFFGYRAEWGCIESKASLLANFNQSDGWKGKNFIDASCNPFFGAKDVDMSNHNIYVPPFNTSINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDL0</accession>
    <name>A0A914HDL0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15652.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15652.t2"/>
        <property type="gene ID" value="Gr19_v10_g15652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1071"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="1864"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="159"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="511"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="756"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="821"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1430"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1536"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1676"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1814"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1954"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2106"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2152"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1435"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1447"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1460"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1483"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1541"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1676"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1721"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1738"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1827"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1965"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2010"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2106"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2163"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2209"/>
            <end position="2226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15652.t2"/>
        </source>
    </evidence>
    <sequence length="2235" mass="237526" checksum="7EF105993FFF4460" modified="2023-02-22" version="1">MPQMELTPRAMAPRLLQLIPSSSDRQVGPVPATQPPQRAVSPTGVPSCSSCPSCCSTPCELVCSSPTVLLSPVLLSRPIRSQSAAHSSSIIQRSASSATNNPSDSESELGTAVCCCSRSCVTNSRLSQCTSRPSNSSSPLATPPPTFLCTSPIPLLSGGSRAVSRSGSFSRHLLQHQHPHSPQPHSPFSSGSHAKVAAPPPVPIGRCHSFSRYGHTNAASNGQRSKATEQPPPPQRHPHRTLAHPSPPGTLSRNDSLESNASAGGELFPHTRRISNSLPSLLSGRPSTAAAHLQRSHSDALDPSLSRQSSAGSAGGGRSNASGIGGISLLGLGGRTATISRMATVDSFSSRRPSISLRDLQQNDLLNSSLDSSGSYPSQNHHPTHQHQHLTSFAHPRHHRLRHSTTTLLHQQTANFQLFQQLTTLNSSASPSNLMRFRLCPLGHSDPQIYTHSQLHPTNFGYGQSPGRNSAAGGGRRSFLSSSPQTHKIRAGLDTSGQKGSALMLCGPSGAASPKTHLHAAAASVASPTTTGGGSGRSDGTRRSPVQMRVHRSSFSSVGSGPHYHGHGQHHQHHPGHAEHPHGASSSARPSISAGCSSGAVRQPVALRALPFGHHHAAAAAENRRWSLASLPSSSGYVTPGTNSGFSSQYSSQENLAGLVANLRIGNRFDSNESYGYCLGDDFGGLMRPRSRSLTSPLRMFDQPGADAPMMSLVYKERFPKAKQQLESRLLQFLQQNAPLSGFSSQLLQQNVQTPSATFSGPLRATSPQPSRPGSTADRSSSPCRPQSPVPMRPLSPLVTESATAVGDAFIRSSVHFSPSSQTLLAPQQQQQLVDSGGGEENREGRQSSPTNRSSVCSPSSTATTTTTAAAMLTTVDPTILRLIADGATRFLHHQLCEIAADCLQKSRDGLLSCAYFCNMSVRLDETLAEAEVKIGPDSYNYLTRLVKQLLMIVSRAARLLECLEFDPDEFYQLLEEAEGAVRVQLGAGSARVPDLPQYIVAKLGLNKNIHQLMDDDETLGDDDAAGTETAAANKRTAAAADVGTDELEKKRMAEIVGKSLAQGAPKEDDFDTVRLISNGAYGAVYLVKHRRTRQRFALKKMKKQTLLLRNQIEQVYAERDILTFTDNPFVVCFYGSFETKQHLCMLMEYVEGGDCASLLKSAGTLPIELARLYVAETVLAIEYLHSCGIVHRDLKPDNLLITFMGHIKLTDFGLSKIGLMNRTTLVSEGYLVQDDTQQFKDNQLCGTPEYIAPEVILRQGYGKPVDWWALGVILYEFLVGIVPFVGDSPEALFANIINEEVEYPEGDEALDADAEYLIRLLLERNPLDRLGTVGGAPQVSAHPFFAPLDFDTILRQKAEFVPQFENDEDTSYFDSRTDRYNHDANESAEDDDAVPMFWSFSTASPRHSIVGLELPVGSMAMLQAAHAAAIERGGQQQPHQQDSVGDDDRAEARERLPSFATTVSSSGIGSGPNSAFGPLPSSALSTRTNATGGGNCSDSQDSQGSAVGRRAAIEFGGDVMPSAVILRRRFSNQRHHTNLSSTSSSAGTTVGTAAGGGVGSSTDDSSSVDIAATSAHFEQPRRSQGQLPRLAISPCGSTFNPAAVGITAQRDGAGGLSHFQLSGGGGTSSGEFLSPVDERRVTVGGDGALKRMEKRPSAVVHELITDVSRMSSAFAQPLARQSRSSSCRISDPHHHHHNQSSSLKLQIPAAGGHQFHHQHSSANSSAGISPQQPPTIGTSSSSSHGTTYYHSYAGNNGRTLSTTTEKIGAPSCSSGQISPSCNSVSSVSSLDSQNAAQKQSNETVTVVQQQYTETHYGGPPPPPSGQPSVCTSSSSLLPPPASSHAAGPPTHHRSSISGGSSRPIVIRKGAQGFGFSIRSVRVYLSEVSDYYSIEHIVAAVREGSPAWEAGLRTNDLITHVHTQSVHNMTHPEMMRRLLSCGNELTVHVVPLSGTSIKEGEPRRNIGKPLRKKPRRPPTAQQKGKQPSRKSSALLRRLSGKRTAGDIVPGTSSQKQMFMPRSVSSQEGVLASGTASAGPASHSSTAAQNAGGGQSSRQFLGPTDRPSAYCSNSKRLSIPAGNELLCCPSSAVSPLAAGNGALTVSSATSGASPTPGVSTTTISPSHPPKSPLVSASTSAAAVFTSDEFRQKKHSITKVQQRQSAANATQNSPTSSSSSLRTKLTESTPIFSLRRQAGSADGNASVGGEQQQQQRSPSPARRVSPSRLMQRFFRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDT6</accession>
    <name>A0A914HDT6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Titin-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDT6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16586.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16586.t2"/>
        <property type="gene ID" value="Gr19_v10_g16586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16586.t2"/>
        </source>
    </evidence>
    <sequence length="174" mass="20375" checksum="1949C047698C2F80" modified="2023-02-22" version="1">MECKIPEETGRVTNLKKPEETKTQKILVPEKIEMKKIPEPPERMGPEERQTVEAGRVTNLKKPGETKTEMILAPEKMEMKKRPERMEPEERQTEEAGRVTNLKKPEETKTEMILVPEKMEMKKRPEPPERMEPEERQTEEAGRVTNLKKPEEIKTEMVLGPEKMETKKRPETSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDV8</accession>
    <name>A0A914HDV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16449.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16449.t1"/>
        <property type="gene ID" value="Gr19_v10_g16449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16449.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8824" checksum="AACCFEF0EC38A1D3" modified="2023-02-22" version="1">MPEWRKMHEYVWAFYCDCPLNFVGQFCEVSQRPLIDVWPIIFRAQMAADVMSRHTGSLGAELRIFLLAMRVRMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE03</accession>
    <name>A0A914HE03_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Lipid desaturase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the wntless family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HE03"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16266.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16266.t1"/>
        <property type="gene ID" value="Gr19_v10_g16266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="800"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid desaturase" evidence="14">
        <location>
            <begin position="149"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="15">
        <location>
            <begin position="436"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="13">
        <location>
            <begin position="543"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16266.t1"/>
        </source>
    </evidence>
    <sequence length="877" mass="100473" checksum="00ED40F38E607324" modified="2023-02-22" version="1">MFVCIFNLSPSARAPRELEESSSSLTINHPTSQKRNPAPYSLVPARRIVRNMQCPTSAYRGPISHNQRMKCPSLIEKLSFEASMSEDDTNGNVNMRMAEAKPRWGPTHAGAKQLASMYGRGKRLQEILCICTASFLFLSLILASLFGVLMADFSSGVVHWGADTWGTVDSFVGKNFIRSFREHHVDPTAITRHDFVEVNGDNFMLCIPKLAQIAWQHWTSDPRELEQHLQLHWFWFLFGFYVAMTNQIHKWSHIYIKLPGWVLFLQQCHVILPRQHHKVHHISPHACRYCITTGWLNLPLDSIGFWRKIETLIRHCNRYKFSNFDSMIGYVIENLSNRKLFLILTLLLLLQFLFFLLGAFFAPGPSSSMEFVLSACVDKSAGESDELFHLRPGKANCMLVPDLKQHTPLSPDARDLVFIAQMPHMRGGVHPETTFASEEVLMELEVRMAYRRKGDSSGKWIELIRTTVRRTSQCRVDSENLGFSLNCSLLDLFQFGSLPHPQYLLNIRIPANQTLCLLTNNKGPNCAFPGPLRELRLIEIHQNGGFTLIWLWLKSALFPMVLSALLWFFRRVRALPRRPVLLEKTIFALGCSLLVLDVPIEWISLRADVPALLLIGDLRQGLFYAILFTFWLIFAGEHLIDDKGRNQLRNYWRNLSLVLFSSFVLLAFDVSERGRQLTNPFHSIWSSEGSPRLATVSIVLGVGSAVTYMLFLLHKVCVIWHTIRQKSEAELRRNNPERRLKVEAVLFRFRFLMLFTLVCAMSTIVSYWMQRYDDGLYVPIEGEGEGEDGELAQWNPMGRIFSISASAFFTGTLGMWNLYVLLLLAMYAPSHKHYKNAKVLEDENEDLMEPDSRHPMETAAPLEDAIPMMDFLKPAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE84</accession>
    <name>A0A914HE84_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914HE84"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16541.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16541.t1"/>
        <property type="gene ID" value="Gr19_v10_g16541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="13">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16541.t1"/>
        </source>
    </evidence>
    <sequence length="574" mass="63503" checksum="E4C20C226414D984" modified="2023-02-22" version="1">MAYFWSQLGGKKLECGGHLYRRSRHRGDSIYWRCDQNRRYGCVGSARTLGEEEGIEVELGKPHNHEPCPARCAALRLTRRIRRTALAAGGCLPPRAVIEECLAGASPDVRAALPHVESLKRAVYRKRRNADGTQQQSGTSADYFDFPEAQKAESNSHEVQAVITVKGEEIEIPMHDSHENPVVPSSSELALSRQAVLVSSDQQQQQLQDHEQLPVVVGYDFNAGIHWEALLDSFMTTGFQASHMGIAIQEINSMIEERSAPVHFEPGVDPFFDYPQNNGRRRRGLTIFLGYTSNLVTSGLRETFRYLVEHDQVDCVVTSAGGIEEDLIKCLRPTYLGNFKMSGTELRAGGINRAGNLLIPNSNYCAFEGWLNPILDECLEEQRHQGTRWTPSKLIARLGSEIGDKRSICYWAWCHRIPIFCPALTDGSLGDMLYFHSVKNGGDGIVLDIVEDLRYLNTMAVRSLRTGVIILGGGVVKHHINNANLMRNGSDRTVYINSGQEFDGSDSGAEPDEAVSWGKVKGTARAVKVCADATLVFPLIVARTFARAVAQRRHRRGVSGGGQQHQTPCSSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HET0</accession>
    <name>A0A914HET0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HET0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15955.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15955.t1"/>
        <property type="gene ID" value="Gr19_v10_g15955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15955.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10308" checksum="D8C99821E5404F6A" modified="2023-02-22" version="1">METEEFFLYEKLSAPRQSLAQIRVPAGQIPSVWKTFGALRVQGRSAGLNSAQRRQRAKENWEAKRKPLALPRAQLLEMSAEGQNAENNPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HET7</accession>
    <name>A0A914HET7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g1670.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1670.t1"/>
        <property type="gene ID" value="Gr19_v10_g1670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF5">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1352"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1559"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1985"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1620"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1884"/>
            <end position="1932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1670.t1"/>
        </source>
    </evidence>
    <sequence length="2189" mass="247428" checksum="6D3A67B126B97B3F" modified="2023-02-22" version="1">MDVGFGVPISIDWRLTDHCVTRTGRCGEGGGDCVVVVMLPHHPSVHSSDHLHVYSFPHHPSVHRPFIRPSSHPFIPSSSIRPFIRPSSHPFIPSSIRPSSIHPTIFTSIHSLIIHPSIHPTIFTSIHSLIHPSIVHSSDHLHIHSFPHHPSVHRPFIRPFSHPFIPSHPSVYRPFIRPSSHPFIPSSSIRPSSIHPTIFTSIHSLIIHPSIVHSSDHLHIHSFPHPSVHRPFIRPSSRVFIPSSSIRLSSIHPTIFTSIHSLIHPSIVHSSDHLPCIHSLIHPSIVHSSDHLHIHSFPHPSVHRPFIRPSSHPFIPSSSIRPSSIHPTIFTSIHSLIIHPSIVHSSDHLHVYSFPHHPSVYRPFIRPSSHPFIPSSIRPSSIHPTIFTSIHSLIIHPSIVHSSDHLHIHSFPHHPSVHRPFIRPSSHPFIPSSSIRPSSIHPTIFTSIHSLIIHPSIVHSSDHFHIHSFPHPSVYRPFIRPSSHPFIPSSSIRPSSIHPTIFTSIHSLIIHPSIVHSSDHLHVYSFPHHPSVYRPFIRPSSHPFIPSSIRPSSIHPTIFTSIHSLIHPSIVHSSDHLHVHSFPHPSVHRPFIRLSSHPFIPSSIRPSSIHPTIFTSIHSLIIHSSIVHSSDYLHIHSFPHPSVHRPFIRPSSRPFIPSSIRPSSIHPTIFRVFIPSSIRLSSIHPTIFTSIHSLIHPSIVHSSDHLPCIHSLIHPSIVHSSDHLHVYSFPHHPSVYRPFIRPSSRVFIPSSSIRLSSIHPTIFTSIHSLIHPSIVHSSDYLHIHSFPHHPSVHRPFIRPSSHPFIPSSSIRPSSIHPTIFTSIHSLIIHPSIVHSSDYLHIHSFPHHPSVHRPFIRPFSHPFIPLIHPSIVHSSDHLHIHSFLIIHPSIVHSSDLSSHPFIPSSSIRPSSIHPTIFTSIHSFIIHPSIVHSSDHLHIHSFLIIHPSSSIHPTIFTSIHSSSSIRPSSIHPTIFTSIHSFIIHPSIVHSSDHLHIHSFLHHPSVYRPFIRPSSHPFIPSSSIRLSSIHPTIFTSIHSLIHPSIVHSSDYLHIHSFPHPSVHRPFIRPSSRPFIPSSIRPSSIHPTIFTSIHSLIHPSIVHSSDYLHIHSFIIHPSIVHSFPHHPSVHRPFIRPSSHPFIPSSSIRPSSIHPTIFTSIHSLIIHPSIVHSSDYLHIHSFPHPSVHRPFIRLSSHPFPSSIRPSSIHPTIFTCIHSLIIHPSIVHSSDYLHIHFPHHPSVHSSDHLHIHSFPHPSVHRPFIRLSSHPFVPSSIRLSSIHPTIFTSIHSLIHPSIVHSSDHLHIHSFPHHPSVHRPHILPNILYFNLYGSRIPKSHRGARERRLTIDLGSAMFSSSPASTANLGPSRSQTPTNPLNNVQMNGSFTLTLPRERPSPGPKCFGKSTHMLKEDYERERARWEKKLEEAEQKLSEAAVHNSELFQLKAELNRKIIDFEKSQRPLIEQNRRLNERIKAANGETRKLEEQLAHVQDELLTLKDAYERVQKENASLRELRAFPEKLEELSRYRAQVLEMSKCITALRQSAVEKDRRHELLVMKMKRMRKSAVQESDRQSCTAGSEGSVEDSGSIGLDTITEDLDEEVELSAAAFAIIGDGRGQGGEFMLLRQQMEMASEEAVAELQRELERVREECTQRISEETGGVRHMLDTARRRERKLDQQLANAQALNELLEFQLVELTAMKQQRDFVETTDTMCATELSLPAIEEPLDDEPKKRRTLSPELLHSTNEALCKAFRSPLLSREDKVAIKHAMEAIECLRNKNGFLESELNMAQCEMGRLRRELETREKEWNGQREAALNERRQKKRELKTELDQLKKERSEEASGYARQVEELSGSLSAKMHTISDLTDRTAQLGAELDICRCQLTTSQVELGAIKEQIGECLREKDKTEREARRLRAELEEAPEKLAKEREERRALEQRTETQLNVMKSEQGKDRAEVNRLRTYNRELEGQFNAQMEMLGALKRKLLAIKDKEGGSGKGGGATRSCGSTEDEQYHSEGSDESTANGRMATKVTVVVGRANLPIFPLHFLPTFKSRAKSIAFLCPLIASFPSIPGFHPLSLVSSVAPMRRSLPSSLPFRFFLLPLLFLIASISAAPTIDSDLIPPARFYRTLWSFNPKRSPSIGLSLAEYMAAGNQGQEQFHFIPGSGRRNGGLTLMAKTTLKIFPSSSADGEQSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG34</accession>
    <name>A0A914HG34_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG34"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16842.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16842.t1"/>
        <property type="gene ID" value="Gr19_v10_g16842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16842.t1"/>
        </source>
    </evidence>
    <sequence length="913" mass="103650" checksum="1796EB523B0C04D1" modified="2023-02-22" version="1">MKSRGRVRENLAEKECVRTRLMKECVDLFGTKDLYQILKLDRSNNSFNNKQIKKAYYSLSILWHPDRFASAHHDEAARELAKQKFQVIGRAYAILGDKEKRQIYDETGLLDDEDDFDDDTDWTAVWRGVFKKVTPEEIEAYLAEFRGSQEEIEEVKKAYQKHKGNMDRIMECVVGAEQPDEDRIREIVRHCIERGELSAYSRFTNEPPAAQVRRAKRAQREAIEAEQALKELRKREAGASEGEDTLSAMIRSKQRKRSEKMDDFLENLAQKYGGSSSKKMPVVRSVSGCQQIRHPTSLSVSELYDGFRQCNKLSGTGHELLLIPSRTERRRPLSVEHIERYRNEPKWRRIRLAFYSAFWFGWLFALLFAVFLAHSHPKCLPSTRDWWKDTVIYEIWTLSFQDSDDDGIGDLVGLQSRLGQLRRIGVGAIFARPMVRVENSGLGVLNFLALSQQIGTMNDFDAFVNAAHRKGLRVLLDLPLAVTSTGHPWFRRSALAVRPENAAFADFYHWRRAIPNSAFVSAFEGSLLKYFHVANRADLSVLNWQNTNVSGAVRAAISFWIGHGVDGFHLSSIDYLHRTPDGRMPAWDQIFAIVKSLKIHAEEQWRIRRRTDGGKIFLFTSHEHLSEALKVRIVEEVGLDAVVNTELRKLALDNRVCSNSTMTTTGVAECTNEIVADLLLFHQSSTNVWPVWSVGSSFTARLATRVDGKAYAELIMLIQLILRGTSIVYYGDELGLRDVPNLKFPQRSTMPWEPSPQNGTTDTATAAITTETNFEDELADSRSFLHSVRRLARLRQRDTVLMADGGGHTYITKCVDGQAFALCRYLSRERAEDGQDSVYGDSIVVVVNFGPVPVVLSLADLPPFHRSGIYRRGRIVARSSNANDFTIGIGIDLGGRQVRIGARQGIVFRAFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGH9</accession>
    <name>A0A914HGH9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGH9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1696.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1696.t2"/>
        <property type="gene ID" value="Gr19_v10_g1696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1696.t2"/>
        </source>
    </evidence>
    <sequence length="171" mass="19294" checksum="BC3775CE317CC62D" modified="2023-02-22" version="1">MGTIVGWGSKNERPDKFLNEMHVSIMSNDYCDRIFTDLGYTYRKHSLICASFANRGIVHGDCGGPLQVEKDGIFYLVGITMSSFVAHAFRNVIPDVYTKVSSYCEFISSATHNQVHCLPHEYSGSELELKCGEHFNKLLFDRYLENCMIITDPVSGATKNVCREPVHINKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHD4</accession>
    <name>A0A914HHD4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHD4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17181.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17181.t1"/>
        <property type="gene ID" value="Gr19_v10_g17181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17181.t1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54975" checksum="EFFD91780629393C" modified="2023-02-22" version="1">MRLLPGPSSSSEEVDDASAEGSPCRSPLRTPRASHRSVPRAFWCRPRRRFCLGICVAVVTLVANFALLFVVLDILLALLRRRCTGGNGQQKAMERILPNIVRPALLVNFSDARSPIRVPTPAASAPPSRNNSVPSSSRGPGVALSPPATPLFSSPSRPSLPSSSSSAPPPTSTRPRLRLKANGTTNKSSKYWSTSSATTTLPRIRVSAADRMALARENLFTHAKHLPYLTVVTALLDIGRDRWTQYGRTLHQYHQFMRNLLQLRVPMIVIVDEKSAEFVHRERARTDLGRWTKVVQLSPQQLPLAVFQKRISQLMESELAHWRPEWDPAMRTHPEASQAEYVVVVNSKPYFLAQAAADNPFDSEFFVWLDAGYGHGDRSVFPASWKWLPTFPRDRISTIKLTPPGDLMMRYGLEELYRQDVAVLSGGFLAGDRRAVTRFHREHHRMFLELLEKGRVDDDQTFLVLLVNQHPELFNIVNGDWFDAFQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHU0</accession>
    <name>A0A914HHU0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytosolic fatty-acid binding proteins domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHU0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17500.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17500.t1"/>
        <property type="gene ID" value="Gr19_v10_g17500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17500.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15456" checksum="932AAE3EF27AE826" modified="2023-02-22" version="1">MAEKFVGKWNLESSENFDDYMKQAGVGFVTRKAAGALKPVLDMEVNGDHWKMTSTSTFTTWNCEFDLGKEAEVKTADGRNVKSLFTFDDGKLIEKQTKTKPDEKDSYFERYIDENGKLVITMDCEGVKAKRVYVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI82</accession>
    <name>A0A914HI82_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI82"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17162.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17162.t1"/>
        <property type="gene ID" value="Gr19_v10_g17162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17162.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="32380" checksum="6B04089CF4C31033" modified="2023-02-22" version="1">MRRNEGIWNEIQPLPALRSIRMHQQQRDPSVRRRLHSLSSSVHPSQFIAPRRSIASTPLSSILRNFHFLIIKANFGRTMGHRRKEPPLGSFLMLLTTAFCSTNAQQSAADLAVLSSPDNMKKLAEIYGFATQIMNLGGSFLGGGEANGGGGGINRNGGRSNGLNSVLGEVIKPSFGGYSDYRGASNNPMGSGGSQSFMPTYGEYGGGPLGAGSSRPQSRSIIESLMGTFLGSSMDSEQPPSSPVYAPNFAGYGGSSQHQQQQKAGAGSNIDAIVRTLMRNGAKKAEASESDGPTSFLSQFFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKQ5</accession>
    <name>A0A914HKQ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HKQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17523.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17523.t1"/>
        <property type="gene ID" value="Gr19_v10_g17523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17523.t1"/>
        </source>
    </evidence>
    <sequence length="650" mass="74045" checksum="08E3E1B281A7750A" modified="2023-02-22" version="1">MIERKNDDGNECVIYFTKEKVAMFGGQTNANGSGVQICVEPLNEWKIQEIGYDGVEKYTKPLAFKDLLRKNARNIDWSKIIGGEAIFDAAIKKRDSEDQLDETSNELAQPSKSFVEPVAGPWALVAKHLHYSLQEVNVMLDCMRIARTDYLNTLVTALVQDERAEAEQVAASKAFHLHTRRRVLNETSKDIERMATARLGVVSVGSDKSDFFNELRELRENWRIRKVGPNIFGDLGYKTFAPKFAPHEVFDVTQKSASNRRESTIRYSNKSFIELRLPQHLRCRTELFVSIETDDEKSAESLFKVTDRLSTSEEEVKHVHWRKALPWAQDSLICRDILARLVSESVSQQDIITLTTDNSIVISLFDSLLLKVETRFRPFEACRTQSTYLSQCLRQLFLAEHSKKTKRIQQFVTLPLVSHAEGLNMRGPLALSAEEITARADGSTPAEVQSSSDFLIRRIIDFLESHMGSFNDPQIQWKWIRATPTFSMISLNFSSRGFENLGKFTSLIRISDSSITLISKESQQIECRRDMEMFENALLLLAAHFLLNSSQVLSRAYGWQLFHANSNAFDLAGNFAPTFYACNQNGTMSIFIQFHADGSSPSIFMKDNKKCSQQQIDSPNLDGFQCLNYRRIPGTTFMRKIDNLFATFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMG7</accession>
    <name>A0A914HMG7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HMG7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2147.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2147.t1"/>
        <property type="gene ID" value="Gr19_v10_g2147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005353">
        <property type="term" value="F:fructose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990539">
        <property type="term" value="P:fructose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001511">
        <property type="entry name" value="Solute carrier family 2, facilitated glucose transporter member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2147.t1"/>
        </source>
    </evidence>
    <sequence length="507" mass="56022" checksum="85F8E8DF5E04CF70" modified="2023-02-22" version="1">MESKWPSTPSSISVAQNSHTLELKEGRLTRILAFSVLMASFGSSFQMGYHIGCINIPADIIKEWFTESYEHINGVPITAKKMESIWAVAVGIFAIGGMFGGIMVGTIADRLGRPSAVMTAAKYVGVYYLIIIGRFIIGLNIGLNSGLSPMYLTEISPINMRGSIGSIHQLFVTISILASQIMGLPYFFGTAERWPLIFAFTLVPVLFQLVVLPFCPESPKFSLIVKGRKEQAENDLKRLRGANDVRHELEQINEEAIASRAEPQLSMRAMLRMPLLWPLVLAVFMMLSQQLSGINAAMFYSYDIFKSAGLRGQWPDLATLAMGAVNVLMTFISVVLMERLGRRTLHITGLVGMLLSSAFIAISMLASQSIQWFSYFSILFVLLFVISAAIGPGAIPWFFVNEIFPLNARGNANSIAVLSNWGSNAIVGFFFPILNSIMNEYVFFVFTAILVVFVIFAAKFMPETKNKTLDNIQIEMDRRRGVPMSQINANLNNANGKTAGKDAIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMP0</accession>
    <name>A0A914HMP0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMP0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g291.t1">
        <property type="protein sequence ID" value="Gr19_v10_g291.t1"/>
        <property type="gene ID" value="Gr19_v10_g291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001135">
        <property type="term" value="P:regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="1">
        <location>
            <begin position="132"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g291.t1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55857" checksum="E419532FAD3C024D" modified="2023-02-22" version="1">MNDGNDVTAYFSNLSVFRHCDLAALEDFELLGDIFAFIGKIVVEEIAYLLLVTECSELGQIETVNASFLRIEKVCALPVLTDGMIHKKLFDMSPLDNLERLKSRPKDLLKLVSHKVPIKNLPTSPKLIEEIVAFFNQPKSFYFALNFDITKTLQRGCLESVVSDNRFFWNKDLLKELFVNNGTPIPAFKEWITPVIYGFIEHKSIVFDVDVRVHITLISRRSVKRAGVRYLRRGIDENGDVANFVETEFIVCVFGHCLSFVQCRGSVPVFWSQKGFQLKPPLVIDRPLDISLPIFASHIKHLTSIYGTPLTLVNLVDESGKEASLGEVYLQHVLSLDSSDVAYHSFDFHRICGNRGHHKLSELMATLDKSISAIGYCWVDKSGQMVLRQKGIVRTNCVDCLDRTNVVQSAIALIVCLNQCRKLGIVEPISEAPMPLTRTLQQMWADHGDFISKQYTGTSALKGDITRSGQRKLTGMTARELMFWDSSERIELEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP29</accession>
    <name>A0A914HP29_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sepiapterin reductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HP29"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g292.t1">
        <property type="protein sequence ID" value="Gr19_v10_g292.t1"/>
        <property type="gene ID" value="Gr19_v10_g292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004757">
        <property type="term" value="F:sepiapterin reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051721">
        <property type="entry name" value="Biopterin_syn/organic_redct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44085">
        <property type="entry name" value="SEPIAPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44085:SF2">
        <property type="entry name" value="SEPIAPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g292.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33029" checksum="29AEC3E96C3BA4BF" modified="2023-02-22" version="1">MASTAKLEAKKVLVVVTGASRGIGRELALQLAKYFEKSECVFVLYARDKEALEAVKGQLLKENPLATVELIFADLSLQPFALGSIDSRIRACEEKVPFDLCLVFHNAGTVGEMAKRSSELNDESQWHEYLQTNLVSAILLNNGIYGALKKTEEAGRLFIVNITSLLSVKAFPSFTQYSVGKAAREAYFRAFAVEHPKCRVLNYAPGPVDTDMHAEVREKTYDSSVREVFSKHRHDTNLHRKLLRPEETVQRLIQTIAEDKFEKEASLGVDRIGKRMLSCEVAEEQKDGKDSKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQG2</accession>
    <name>A0A914HQG2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQG2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2758.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2758.t1"/>
        <property type="gene ID" value="Gr19_v10_g2758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2758.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="42331" checksum="6F1FD7B5735D30A2" modified="2023-02-22" version="1">MLPVGAFSGGPFLPPNGPSMSNGSDGLSAGPASTLSISALLMACASGQLPQGCFACTYRLKDDQLCGCVFPTEEQLFAHYKSAHIGKQSSPNVVSSTSSQGEQSVSATSTSSTTSADNNGSAGLPSSSRPMGPPMSLQTMVAAQQWKQAVSLTSQHQSGAAYANHRFHPYAQASGILSQQARQYGQQTPNFQQMAMAFQLAALTTMANSIRPGGWTPTGITERQPQTSVMWQQQRRQLQQHLGSAGSSTGPSSTCSSSADTVEVIRTERERPTECVGRNDGMMQTTPKRPRKIVMAPPRSVAGDDPAKAECEICHKQFGRPWLLNGHMRTHNGNKPYKCETCDKTFADRSNCRAHERTHGVEKPFECPRCQKSFKVKSYLTKHKKSCGKMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRC0</accession>
    <name>A0A914HRC0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g393.t2">
        <property type="protein sequence ID" value="Gr19_v10_g393.t2"/>
        <property type="gene ID" value="Gr19_v10_g393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062:SF1">
        <property type="entry name" value="LP12374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="495"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1273"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g393.t2"/>
        </source>
    </evidence>
    <sequence length="1298" mass="144828" checksum="477491252AE78F5A" modified="2023-02-22" version="1">MIEGVQQVSEGTLGTGGEADVAKVPNPPMPPNLSPSSSSSSSFTFVSDPFLVLDNDLDDVSEVIKHNIMTDESSGDSTPSHSRLNKCSDNETPTDKRWIQMEMTPPNSFDPCKEREIGQIVSLLQQPDPPSLEEPSPQHLQPQFVLNNDHLEYLSAGISGLEARMPPQGMFTGQKDPMISGGDNGMSPILQLKTHHLTGEQFCDMGIELEQCPQQQHVVLQHHNVHYSHNNMPFPTSHAIDGTPQIQHFVVQDNGTVILDNKGIHMESPPPLVLEQQQNIKEEMLFAPSDNAFGHHRSLQVVVEHAPYDQRAEASDVVKNELIRLLLEMSPQELEQLRTQRALEYQQHQQHLLYSQQQKFQTQTCHPQQLQLEHPLVQLQNITPAQQLQHKYSSNGTEHNMLLIHAPSSNSFCPSGSINSPTLTSPNAFQSVAPSEYFGEEDSAVEEICWTEGETAMDTSREEDALVEVGKLTEAAQRHNDGTTPTGRRRGHKTERRTAHNLIEKKYRCSINDRINQLKEMLSTEESANKLSKSATLRRAVDHIFALRTKNSELGRENVRLRKTLQMAGLAPPERQTMALVKQEVRMGEVRTTGNGVLQNKAPRGGIASMRRSNTVGGGGSITSGQAKDQSRVTLCVFMFLLLAFNPLSTLFFTNEAADGSEQYLQHNIGTSAEPGIFVHHRTLLGDDRFSAAFSEGSVPLASSSPPPLSSSSPGGWWPVRPFFRHFLIWLLNSLFVFLILTRLLVYGEPVADRHFLCSTANCRRRAEMAVASGNYKEAQRELGESLKILQRPLPCNGSVDEWMSLTWQIIRHLLNGLWIGRWFARRRRPSVPHQSVCRSHAATALVYHQLHQLHLLDVDGIRLTSRGALNLALLATNLAESAGSPAIPHSFRAEIYLCAALRSILCMPKCLRRVVAAYFFRRAKRHTRKSADLEGCRLNSVQWTFHPLARQFLSCTERVGAILSQSGVQKTPNFPFSAFAQPPKPLEVLKDSFKMHLLGQLLCRLESSDGGTLRLADFVEQSQLLLNICEGGNAGGAAESTAEDPKNEGTDGKIEGDYDVPCYTDKDMLRPILIAEGDELCAWWTYLVTGGLHWRHGDSVRAQRHYSLVRKFPRELAQNDLALAVGLAFCTRKMCFEDREKDKFAEVVVWHVRRANAHLKRDDWPTMGRDRAGTLEGMLPRGKAPDGSVSILKKKFRILCCQWLLCSLLDVWSFRFAHCGLVAPLEVRRLYAEVMGRIGREGEANEEKMAMFRELGKTLCGLHQLGNQLSALQEGNAPDGGGPTKSNAPRQSETEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSA0</accession>
    <name>A0A914HSA0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSA0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3760.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3760.t2"/>
        <property type="gene ID" value="Gr19_v10_g3760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3760.t2"/>
        </source>
    </evidence>
    <sequence length="538" mass="62971" checksum="409BBEC4198FC8DC" modified="2023-02-22" version="1">MAVIGTAECGCIWSKPAHTTAGSGQSTRRQQQTATTSESYPLPIPQNRSSHPIPIPSKRKSSFKKTATSSESSLPISSKPATSSGSPPLLPMGPLPRFLPAQQMHPPVPLPLPPGKSSSKKTAESSGPPLLRMNPELRYRPVEQQNAAASGQSGRTQLLAVVKAHDANRERRQHPNHTHCQFLKIRRHHPDHQHCVQWDHYRVFFLLLGLYTECHGLQLKGRIYTHCHRLLLPKIRRHVAKCQCQKQREDEEELIDEWRRFFRLLMEQQNAAASGQSGRTQLLAVVKAHDANNKRRQHPNHTHCQFLKIESRLPRKRRHYPDHHTHCQFLKTRRLHPDHHTQYQFLQSRPRCCVFVLLLGRIYTECHGLQLKGRIYTHCHRLLLPKIRRHVAKCQCQKQREDEEELIDECGDIIRTIPIANTSKSNVVFQEKLKLDEIVCLQERRLPRKRRHYPDHHIHCQFLKIRRHHPDHQHCVQWDHYRVFFLLLGLYTECHGLQLKGRIYTHCHRLLLPKIRRHVAKCQCQKQREDEEELIDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSB3</accession>
    <name>A0A914HSB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3496.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3496.t1"/>
        <property type="gene ID" value="Gr19_v10_g3496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3496.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13233" checksum="666ED7F29483881E" modified="2023-02-22" version="1">MRRAKKRTAHKAAQRKKARRAHSRAAQKNAPRKKARNAKNRAAHIAAPRKKARSAHAAPRKKRATQKTAPRKKVRRAHSRAAQKNVPRKKRATQKTAPRKKVRRADSRAALIAAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSI9</accession>
    <name>A0A914HSI9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSI9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3560.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3560.t1"/>
        <property type="gene ID" value="Gr19_v10_g3560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3560.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24181" checksum="11D91D8C11D016D2" modified="2023-02-22" version="1">MSLNVAGVNLNEQFFRPNFPIFACDEFVRRDQFSEHCAAHLAYEDDGLAFFARCPNAQYGCTFHSDHQLLTVDGGLIRLWRTDAHLQTRRPPRGRRLLEGFECLSECALRLYCSNASTCIERAYIQHCSSSWSRLPAGHCTRAQLEQLLENNNNIDGKHFKMHGDGVVEEEEDSSEEEAKITASQYRAMREPFLGCRLCALDPVLNIFTSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUW6</accession>
    <name>A0A914HUW6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUW6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4394.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4394.t1"/>
        <property type="gene ID" value="Gr19_v10_g4394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4394.t1"/>
        </source>
    </evidence>
    <sequence length="755" mass="81869" checksum="05D5CE5CC35757AF" modified="2023-02-22" version="1">MGLNQSKPNKAKQSPSKPVTFTLTPIGRFPHQSDIWQQLQAAEQHGIGLPLPTGNTPPLLQHQQAQIVPPSSSNSNFFMNPLASPEVYSIGSIHQTPNDGGGGYSPIQPDLGNAKTQYEPPNVQINGSAGSSPRQYRADPVSDERPKESPLLCDTNPNVDNAKTKYVPSNSMHQQNAPLYLPISGSVDGFGSPSQYGIEHPVADKSTNGSPSLCDTNPNVDNAKTKYEPPKSNYQIGSKVVTDNTPPLLQHQQALIAFGSIDQTSNGGGGGGYSPIQPDLGNAKTQYEPPNAQSMEVLTPVPVNTAPILSQTNAQKKAHCSATPIRTQTYKRKPIALRHQSGRHQNAKNSQQTQHDKMNDQGNGEAPTNGTEQESTMTVVGELPSNGTEQESTMTVVGELPSNGTEQESTMTVVGELPSNGTEQESTMTVVGELPSNGTEQESTMTVVGELPSNGTEQESTMTVVGELPSNGTEQESTMTVVGELPSNGTEQESSMTVVGELPSNGTEQESTMTVVGELPSNGTEQESTMTVVGELPSNGTEQESSMTVVGELPSNGTEQESTMTVVGELPSNGTEQESTMTVVGELPSNGTEQESSMTVVGELPSNGTEQESSMTVVGELPSNGTEQESTMTVETEPRVEKGNERVDRTLSNSSKKMLGVIGLIISLSLLCWILLKYGGTMREWILWIREWIMVIYEWIVCAHQWIICIYDWIMWINDCIMVIYEWIVCVQEWIIWMHESALRIYHWTLWLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVF7</accession>
    <name>A0A914HVF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4537.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4537.t1"/>
        <property type="gene ID" value="Gr19_v10_g4537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="14">
        <location>
            <begin position="381"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4537.t1"/>
        </source>
    </evidence>
    <sequence length="1657" mass="187031" checksum="334225D9B8E07468" modified="2023-02-22" version="1">MFSKIFAVYLYESVRISEAQLSVKESVKQQKNRPLGTLNLPLDHKISKLVRLSKNFIVQLTFRIVDDANNQPIEHFQQTFVRFTHTKSPDHEVFIVAKEHKKLNGYYQLEMKMSRDFVRFNSRPGKYNCELILGDSRVRSGLRLEIFDAFLDISKQFQPEEPSYKPRKRDTPNFERMPEIQHKFKKIEGCKTKYWTTLSYAFCFVCFLPLILLSFNWRVLTLKALQNLFSASDNANFSAPIFFNMLIALFSLYIICWVLGTSIAIELQLTVICAIPCFFACHKMLNALATDRIEIENEALRLEWSQNDHNDDLENDYYYSEEMNTRTNRCKIVPLWKCFDVMLKLHEYLDKLWHKTLSKLYYLNMTTSNQKKIDQLQFDSTTLTFFVNGIRIDVKSIDPRITLAAFLRDKLNLRGTKIGCNEGGCGACTVMVSELNPNSGEIRHYSVNACLSPVCSVFGKAVTTVEGIGGGQKRIHPVQERLSRAHGSQCGYCTPGFVMAMYTLLRNKPEPTYAEVDECLQGNLCRCTGYRPILEAFYSFTKTNGQKTNCCREEKCCMSSNGLVETENRCDSNGRKTHNKLSNLCTLPNIESSQELIFPPELTFGAWNQKSFMMENDGYYWYQPVKMEQLLALKREFPNAHTLIFDGSSTLKIFHLFEHFEVKKMDFVQFVDKLPNQKTKIFAEICNILSLFAGNHVRNMATVAGNMATASPISDLNPIWMASGAKILLKSEEANRIVCLDQNFFPTYRKTLIAPDEAQRREDDIAIVTGVFSVKFYQNKGPRVESMQMAFGGMGATTRMASKPTQNLKGRIWDEALFNDLSGALADEFRLPENVPGGMAKYRQALVLSFSLKFYLYVREQLGLTCEKREMLHLSEIENKFESTQIYQDVLPSQNKTDPVGRPLMHSSGEKHTTGEAIYTTDVQLPSDCLYMAYVTSPVSCGKIIGNPDYSSALCLDGVIGHVDWRDVPGSLMISHSNDVPLFATDQTSISYHGQPIAAIIANDNETARRAASLVHVEILKPDYEEKTIITIEEAIRHQSYLFPEPFRIHSSLNEPNATIKSEIDWKKFSRTIKGQIRIGEGDEMHIISSTQSVNDVQGDVATVLGVARNVVTVTVRRIGGGFGGKESCTGLFAGAAAIAAKKFKKPIRFWLERFDDMAISGNRHPFRFDYQFALENDCDKIAAMEVNAYSNCGYSFDLSKGVMERALAHIDNVYKFGNVNVYGHLCKTNLASNTAFRGFGGPQGMFATETIIKHAAEQFGIDVDTLRELNMYTTEGDITHYGMHLRQCNIRRCWTECQKLSNYDQQKLKLQEWNSKNKYLKRGIYMVPTKFGIAFGFKRLNQAGALVHVYTDGSVLISHGGMEMGQGLHTKIQQIASRCLGIDVSMIQIIDTATDKVPNASPTAASVGSDVNGLAVKNACEIILKRLEPLRKELPNESTWKDLVMHAYINRVQLSVTGFATIHCEPVDFTEGRGAEYYSYCVYGVGCAEVEVDCLTGDHRVIRVDIVMDVGESLNPAVDIGQIEGAFVQGFGLFTMEELKIRPDGVRLTRGPGTYKIPSADDAPRQFNVKLLDGSSNKNGIFSSKAIGEPPLFLGSAPFFAIREAIRNYRIQNGNLGYFRLDSPATPERIRLACEDSLLEKAIPQPSKGQRWTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW07</accession>
    <name>A0A914HW07_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HIT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HW07"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4285.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4285.t1"/>
        <property type="gene ID" value="Gr19_v10_g4285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4285.t1"/>
        </source>
    </evidence>
    <sequence length="539" mass="60379" checksum="1DF33809AC1F3D3D" modified="2023-02-22" version="1">MVESNLLLLETSSSLKPFSSSKCPSNLLQPIASCFVCTLENCGKYKCPQCSVRTCSVLCFKTHKESGKCKAQHQWKQIHGHSQFNEEISIDDKVKFCAPDASNKPPAKVYLPNDQRFLMQNALLRRIWLRLDNTYSADGSRHERFSDTIFWTCTVKFVSRCAAPRVKENCAELTEDRQINDAELLNESSSTPTLSVDAPIFANGGPIVVDYNGGSDDEMDGNGTADDDGTDTDGGGKSDGSSASSQSADDEDEQQRLLESMSFTVENIPENIRVVTLLRQFLRPKPHGPVVSLSQIDMAKMGPFIRASNSLLSSTLAPTSSENECADKLMVYLELSVSNGSDKKSESEHQQTEDDMRYYVVDANRTILDNLRNRHVNGHPCFVVVLRRDAEFGELDLPLMGEEEQKQLQEMSKERGQAINERPKWQQRNNFGRTRNNFNQQQMGRRGAARGNHNLAHQQCPPAVDGGIRPQNQQRFSFSGNAHNQPMNALHFHPYQRPAVQHQSSQWVRPTFPQQGAAGWNMARKFPNSARGNRGRGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWV3</accession>
    <name>A0A914HWV3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5216.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5216.t1"/>
        <property type="gene ID" value="Gr19_v10_g5216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20788">
        <property type="entry name" value="TBC1D23_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039755">
        <property type="entry name" value="TBC1D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045799">
        <property type="entry name" value="TBC1D23_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297:SF5">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19430">
        <property type="entry name" value="TBC1D23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="323"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5216.t1"/>
        </source>
    </evidence>
    <sequence length="635" mass="72231" checksum="D6A4AC7A48598AAA" modified="2023-02-22" version="1">MSQLEDDLELIDENGATSDEWVKEDIGGGGSLSPNVVKELNNNNNDGEVSARFVNASQLTADQLNLLGVRNKPDRLVDWDNLYNLPQQTLLRRDCRHLVQKIDASAKWTVPQLESLMTLYCKRRSVGYESEQCWMDILGKLLLLPLNHCALFNVFWAITTKYIPKSAKMFDLYRLLLQYHDPKFRDWFCSLLSKDMEAELCWTIWGKYFEKGDPFLIFFIALAFTRGVREDILQMNARDDIITLLRSVSGRVVREDVHDLLEICFVHLKLTPISIREDFHCMLFGSNLIDEYFEIPLNRLICLPISVLELYRRAIDLTTPNSTSFGYFVIDTRTQKHFNAGSIPGSYNLSAETLIEDPEKFGYALSSLMKFKEDNYPNEHICFLGFGTTNDGDHLMNMVIAKILQQNFEHISKSDCMECKEGKKEEEDNGKTLTLLKRLKKSLPKRKDSLASGGSGQRKGAESEENVKHVSSTDRINDEDTSQGSMDELRKASATAVVRGGEQLQWADMVKKAEIREHFEGEEVMAPPDDRKVPCHIGLSRTHMHIFHRVHGEPGLVSASLRHSLSSIMRVTSKRRFPEFLTFKFGYELPTGESHINGVHYFILPKAGECAKAVKLAIIALKPSAADDEETLSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX33</accession>
    <name>A0A914HX33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Apyrase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the apyrase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-I AFP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HX33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4583.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4583.t1"/>
        <property type="gene ID" value="Gr19_v10_g4583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016172">
        <property type="term" value="F:antifreeze activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000104">
        <property type="entry name" value="Antifreeze_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
        <property type="entry name" value="Apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036258">
        <property type="entry name" value="Apyrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06079">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00308">
        <property type="entry name" value="ANTIFREEZEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101887">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0047">Antifreeze protein</keyword>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR609283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4583.t1"/>
        </source>
    </evidence>
    <sequence length="435" mass="47720" checksum="56FA4AD9A2E9190A" modified="2023-02-22" version="1">MSANRISASKQFTAAFNISKDFSPIEKDFQNLLHLGAFMNDLDEMALRILTMDLLSSTGQNGTGWCKKKCGFGYQLAVIADLDKDSKVKGKENVWQTFVRRGRLFYDPAAGVVQSDPAAAATPAATAAATAAATAAATAAATAAATAAATAAATAAATAAGVVQPSVKIEWLKLETVEQKLSGNLSDKGRAMELSDLCIFDGHLLTVDDRTGFVYRMDNFTYMKPWVFLKDGPGTANISKGFKGEWMTVRDNKLYVGGLGKEWTTPNGEPVNNHPMFVKVITPGGVVEHVDWTKHYKALRSKAKIEFPGYMIHESGQWSDVHQKWFFMPRRASRNKYDETVDEHMGKNWLLSADAKFANIELREIGEIRGDGFRAFSAFQFLPNTGDDVIVALKSEERNGTGVASYLSVFRLSDNKVLLDDEKIASYKFEGLVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX96</accession>
    <name>A0A914HX96_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX96"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5506.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5506.t1"/>
        <property type="gene ID" value="Gr19_v10_g5506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037792485" evidence="1">
        <location>
            <begin position="25"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5506.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27547" checksum="E0965BCDF7C624E2" modified="2023-02-22" version="1">MNNSLQFNCFLFVLIFNAFPYGEFIELFVKPANFRYKIQLHCPLDEFTRIDIGTALQKANEEKAIFDIPFSLLEYCFEQKLTVRIFKFVENNESDTNGPPNSNFEFIKKFALRSTEANKVKAMVLDVSEGMNLPISLGQSPAEYYFTVIIKCQQLEDQNANKKMVIFATAISSTSQIESMNIGNMDQLEKCQGDTLQIEVSKGAKWKLMTMLASEFRAKLGECLHLNFKEMLFLDDANAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXE6</accession>
    <name>A0A914HXE6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXE6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5361.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5361.t2"/>
        <property type="gene ID" value="Gr19_v10_g5361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5361.t2"/>
        </source>
    </evidence>
    <sequence length="596" mass="67407" checksum="52B796B8C470973C" modified="2023-02-22" version="1">MFNGTDNGKVPRCPQSLGVIYQCAKFHPETPWTPGDLSLYALPFPSLPVTFLSIFEIGRAPSADISSPIVFVPRRRLRAYWPMDGHSPICRGAFEFGDQNNSFYSGGPFHSKRSDIIAIYYKNLLLLLINRRTRKVLSPDDSEKHSTNCAFLFLLAFTNINRIISNFVSFAQVAFYYMSSIGNLSSSLLSSVGNNIHLNASTSLIPDILMTDSLNHSNMSTNSTFMPFSNSLNTSMRSIVPSPVESHQHPLNPYSVVNIFICAPMLLLQLLTLPIFLVYPNYRCNVCFRILFTNGVTDCLQLAPLLTFAILNLITDNIPIWFQRFGSSIVINAWNLLVMQHFLLALNRLIVILRARYLGSRFIPDQETEAKCFNVAHAFIWAVYLVIVGLHQTNLMGSLFHSGTSQFVFDIEKPLTQTVRMVFWYVTIVIPIICLVIYIVIIAFAKLSRTSMHRGDDITATKTTAPLLNDYERRLLIQAIILYVVMGLLIIAWNSFDSCRNDICVGKILRLIPVSLPRAYHTFFIEGLWMVYCGLNPILFLTMNREFRNRFLQLYGIKKSTIFPSTGHTNISRSTASNDTKPATEMGTNILHGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXX3</accession>
    <name>A0A914HXX3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXX3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5679.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5679.t1"/>
        <property type="gene ID" value="Gr19_v10_g5679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5679.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27498" checksum="68CFCFD6B43C0226" modified="2023-02-22" version="1">MQHRNSDDNEIITTLTLRDQQQVIIRRMRDEDINEATDIIRAAYLHDCKKHEHATSEERLCQIFNVPVEKTRHAFHNFHNEKDSVLFVAELAEKNLNVAQLLGCCRVKLNPEGNSKDNGPFGQIGPFATRVGLQGTGIGTALIRVAEEYVVRQWHVCEMQLDARIPKPVEGVVPPMPPLLQFYANRGYRRVGKTTWFNPATSNYVTMPDDLAHLERMVKDLCAPSATTGGDGAKRGHEQLRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXZ5</accession>
    <name>A0A914HXZ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXZ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5070.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5070.t1"/>
        <property type="gene ID" value="Gr19_v10_g5070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037157780" evidence="2">
        <location>
            <begin position="29"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5070.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18186" checksum="0288F0EC2CA23C31" modified="2023-02-22" version="1">MNVQRFVNMPNALKPLVLLLILLTMLLAASSPGKSPSGGWFFWLNITVQFVFITAVCAMFLYECEAFLTLGRDGGWPIVEMSYSGVCAFCNFVNIFILAAGHKTEVEKGSNTFMVAAFSAFFLTIFYCVGGLMMFRIWRGFIKSGASQNPTPNVRAGDIGGMHPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYM8</accession>
    <name>A0A914HYM8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYM8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5875.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5875.t1"/>
        <property type="gene ID" value="Gr19_v10_g5875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5875.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8555" checksum="2E56969FD508ACCD" modified="2023-02-22" version="1">MLLEMFAVLQVERKDKATHLAMSMEQLTEKFDLQLQLLDIEFEPAEFIDIDSREWCAERVKDRGTYKVVGAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYX9</accession>
    <name>A0A914HYX9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYX9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5763.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5763.t1"/>
        <property type="gene ID" value="Gr19_v10_g5763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5763.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18080" checksum="25A564E1219921FC" modified="2023-02-22" version="1">MAYRSSASGLRVSEMSKQANKYNEGEGELLLEWIKELVGGKFSTNGTWDNFHAALKDGQSLCKLSNELDPDAIPKINRPRKLQGVPVHETFQSDDLFEGRDLYSVCMTLYSLGRILEKRGMSHPKRVKNDAILNVPAVDSRLQLRIAQNGSLDKKDSLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I069</accession>
    <name>A0A914I069_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alkylglycerol monooxygenase</fullName>
            <ecNumber evidence="10">1.14.16.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:36255"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="ChEBI" id="CHEBI:73418"/>
            <dbReference type="ChEBI" id="CHEBI:83957"/>
            <dbReference type="EC" id="1.14.16.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sterol desaturase family. TMEM195 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.5" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914I069"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5657.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5657.t1"/>
        <property type="gene ID" value="Gr19_v10_g5657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056853">
        <property type="entry name" value="AGMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF4">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24858">
        <property type="entry name" value="AGMP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="14">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Alkylglycerol monooxygenase C-terminal" evidence="15">
        <location>
            <begin position="273"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5657.t1"/>
        </source>
    </evidence>
    <sequence length="435" mass="50205" checksum="810F7552D10677D8" modified="2023-02-22" version="1">MKLPSPHWSRCQTTTSRSVPVLQIWSSRGTRHGRGFSVFLLRTWPITLVIVPYTRPDSSGDYTPFTTPASTTTSPPRFVKPPSRTRVWRLTTFCRPSSSHRPFSSSIRYFSEIFQFWMHTSLFGSLGPMGFVFNTPSHHRVHHGRNAYCIDRNFGGVLIIWDRMFGTFEAERKEEPPVYGLIRPEQSFNQLWLQFHTLKELLCDKWRLKDEKGESVFPGWTDKVKALFFPPGWMPKARVRLFFHWASLDDHTLGVPLVELPVQKYNPPLSPWLKGYCFVHFLLLLCIFLHFEYDRGQLGYVDFSLKIAFFVCTMQSFGAFFDKKKFAPFLEIFRSIGVIAYYATRTIIERRGGIQPNRIFMAALFAVSAIALAVKPLRDLARRASKVTPKREEAIGTVRKEFANGENGIAEVTDKTTETKRNGVDMDMDRSGCWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1B7</accession>
    <name>A0A914I1B7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1B7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5963.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5963.t2"/>
        <property type="gene ID" value="Gr19_v10_g5963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="206"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5963.t2"/>
        </source>
    </evidence>
    <sequence length="406" mass="45945" checksum="0DF21B15575F4E16" modified="2023-02-22" version="1">MAPLSINIMPILTEYERLEEKIGWLNEDQQKLVSIDQFLLMQSDQKALLEKLNRLEQKQTQFNEREQQLNNFLEQFVEEQNNKFEKLKGRLSAKMVEEYPKQQQVTIGGKIGKNENSAAFSTSGVWRRCDSFRIVGSILLFMFIIYTVHQMNEQKGFRLKMNAFVVAEFDQQKLSNANKFAEIEQHNALQQEKVVKLQKYLKEQQLDIVDLQKIVDTLKEIGQVPENRWDSAACHDKLALSEPDRLIVQLNGEGWGSVRAEKPMSNPYGIAYIEVKILGETAGVLIGLATTQMPLGEWVGHYKGTFAYGSHGDFWGHEIDGCCHTADGRPVIGGKPKFEKGDIIGCGVNLATRQIIYTKNGQRLDNANLFVDSAADSIAVLFPCVSLGNPGTKIEANFGPDFKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3T5</accession>
    <name>A0A914I3T5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bladder cancer-associated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms. Modulates expression of genes involved in the regulation of proliferation, cell cycle and apoptosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BLCAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3T5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7246.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7246.t1"/>
        <property type="gene ID" value="Gr19_v10_g7246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7246.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25746" checksum="7156B32AAB487B0C" modified="2023-02-22" version="1">MRIVQLHKKPQPCPVSSSECLADLCMSYLYASIVRIGPSRQRDGKAGRGEEVGQAAPIAATHQLQIDRSPIDSTTPFHSLTVTRREFLTNSSTFYQSGQGKVAEQGLSRNACGSLPKPASQYFLVLLALVVTEYCSKKEWLMPVLLIPKQMVHPTFLIDQALFLWFYIIGFVLERRPCYICLLLFSMTVLAICYSDEERCVLWPMCETVLNGEMCKSVYESEQQKMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5I6</accession>
    <name>A0A914I5I6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5I6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7704.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7704.t1"/>
        <property type="gene ID" value="Gr19_v10_g7704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="94"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7704.t1"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131373" checksum="DAC727F7789AD245" modified="2023-02-22" version="1">MAYPVHPRFGTYSTRRAHSSADYKGEERPPHYSTSICCSRGRDVLLFSLFGALALTLTLLVAIQIVSFRERNPTSDLFTELRVNVDGDELELFGRKLMVDDGEYFLDIPYSIATPRFQPSQVAPFPGGFSAIHYGNGCPNGFSRTKPAPGINWNPPPLELVPVSEQCHTLNIYRCPNSKSSKQLLPVLVYISEGHWLKRSNANLEPSTTIRRLACAGDGMVVVSINYRMGPYGLFSAPHWPSAQRELALWDIRTALEWAQLNIAHFGGHRAHVTVMAKGDGARLVSLLGLLPGTQSLFKRQILLSGSAFMPVLLQPAPSLNRTSSFDAAMRFAIAAKCVDEREWEVVKASRDKTALAQNEMEARKKLDACVATLGHDAIVVADSLIQRSTFLRWPLLSGDSSSAIPSNPFTNIPSTATMIVICTSEKQWMSGKTEGGHAEDFRKRMDEADDTFRKRLEEAVREEVLERMRRMDDLAGLKYSEEVIRHYVERIGGQGEDPDDLINRIKTDFFLIGPALLEAFVRARLGSARVFGLHFRSSTNVSLADAAEVASNLANPWAASQPSCVDDLLFNPTPRGHNAEEQEQKAVRIFAEMITNFVTYGDPNPDGSAGDGFLPTVYRREKANCEDRPRWLSLNNGTMFNGLELLFGHNLLSENAHFWLSGMAKRMGIVHDGDISGAFCAFVPARFDGRPELDTCECGKIADSCEGQKCFAKLELFPEESVAVLQKGCINGLPPGIDGCNFSGQTESVHCYCSGQFCNDRKELNNFSPAPLPVLECCECSQPGGDDQCPMESCLRSCRGNYCLVDFDGVDQGCGQGMPRLQNFLRIPNYLSTFQGGIACAHYKASDETAVNGCVCTEPSGMCNQRNRTIHRQMENVLTRRADDLNYCYSLSVRTDRGPFDADIYRRSTTCEGHYCFLSLSTRELVVEPDSESIDAEVVKFVGKSKQKYELLAGCLKVDDDKKVSMGCTVEYSLNLTEPLSVHCICDSHLCNYFDLLARAANGTLPPEETTLATTNGRMITQDALQENGSVGLSWTTAAGNFTAFFLILNAIIWIKIVHLEEEEEEKRKKGEGREGKKHNEKEEEEEEKRKKGEGREGKKHNEKEEEEEEKRKKGEGREGKKHNEKEEEEGASPPTRWNGGGESGRPSNNACLSPFLQFVPPPACNTLPIFCSDQSVESISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5Q9</accession>
    <name>A0A914I5Q9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7144.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7144.t2"/>
        <property type="gene ID" value="Gr19_v10_g7144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000015">
        <property type="entry name" value="Nuclear receptor subfamily 2, group C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="382"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="481"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1255"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1403"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1191"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1255"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1403"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7144.t2"/>
        </source>
    </evidence>
    <sequence length="1449" mass="152739" checksum="3A078AE046D7157B" modified="2023-02-22" version="1">MDGGDDVLFAAVVTDDVRTAQRGSRFETWSDLLGALKQTHIAPAPVGAPAALLLIFAASAFRNGTHQAGRSCLGRGALSGRMSTTTASAPLATAASLGNLMDHRATAASVVRSAAGGIDVSSSAVFPRSSTASAFLPPAAAAANSAAFHAAGQYSAAAIKRPLSGLASLPPLLHASTEPNGRRSSPTAALAAPPSSSLQPPPPPPSHALNGLLTLHQQLAIAQQQQQQQQQKHQQQMGFAAAAAQQLAVSGLASPANLVAMMQAVNNLRLHQQQQAVQRAQQQQQQQSNQQNPFVALEQLRTAGGLDQKLDQKHFMSPQQQHHLVTKQPIGPFVAGLSHSAGSNMAGGGAGGVPPKLELNKDSSAAGSPTSVNGCGSTIGSGELCVVCGDKASGRHYGAISCEGCKGFFKRSIRKQIAYVCRGSKDCPVTKFHRNRCQFCRLKKCLSTGMKTVQAERRPMNAAMVAAAAAVAASSVSMTSTDVPSTLPPAVPGGRFSSAGSMSTNIRHHHRQGGPASSATSAASEFSSAFGHSSGSAFMAPPTMVSASASFGPNAFQSVNALAASLYRQQQQLHQHNNNNNNNKRGGSPLGNGAAAELLQHQGGATKRKRLNTGDAPPARNLQSPEHLLTQSSTYSNLQQGLLAFVNRHHQLQQQQIAANNSVDDIRFHQTQQQQPSVVQHHSILVDTSSGSDSGGTTDALALHHHHHHVQLGKRCSSPPHSSSDNDATSSSALVDICGNGGTVVVAARDSHGSPSLLKPALISSNSSVGTGGGPIGLHGSLSPPITSQSPSPPTAMAGTMVNAAGGISANNNNNNNNDASLLAQLLKRDFAFSNQAHQQETTAGDNIVVDTLDGHHADPLLLLELDDSPTASSRGSSAFSVDGAALNNGTGSSSSPPLPALQSPVISAQCAKFELPIPPQLDAQQTPLQQQQQQQSAVTGGVDLGFICESASRLLFLSVHWVKGIRALADQHTLMESTMKGKWCDLFVLGLVQCAHELNLPHMLRTVNAHLCARCRYGQLKWERYEELCRQIALLHLFAQKTRQLKLSGMEFAYLKAIAFTGADLPPRAQHTQLVRQLSLHTGHGAAQLRQLNSLTCQELFEHIVQSQLVRSFGDADTVKRRRRHFCCRKKKAANFDLLETTTTAAAASGGECCADGGSDCCGASSTTAGTATTTTTTTEGGGGGGGADQRSDGTCEKSDECRSSGGERKEDSGNGDEQHELDADGTLILCCDTTTSPGSSASQQQTIVVVTHKREDDGDVASRKAKEQRIKSDVMTDNEEQQHHHTLRGGELGPEEMLVAVERHSLLLQLLPCLRWFNEATLVELFFSTLLGSISIETVIPFILNTNTETIFERNGAVNCTSVSGGEQGGGGRQQAVTGQSAVAAAASLSMSLTLGHVKLEQDDDRHHAEKSDEVEQDDYKHQQQRNRRHSSSSNSSSDRWMNVNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5S0</accession>
    <name>A0A914I5S0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5S0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6876.t3">
        <property type="protein sequence ID" value="Gr19_v10_g6876.t3"/>
        <property type="gene ID" value="Gr19_v10_g6876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM2" evidence="5">
        <location>
            <begin position="820"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="948"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="728"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6876.t3"/>
        </source>
    </evidence>
    <sequence length="1034" mass="115591" checksum="19EB0C9DA1885469" modified="2023-02-22" version="1">MIYISLGPKRPGPKRPWGRNGGAERAGPKRRGRNGGAETSSEELQASAERRRLQRDREARTKARASGGQSSSTADGTSSKSKKNERHKANNDGPNRAKKRKSRTGSPDENSQPSTDKNGTPKLKQQTLSHFFGLNVKNSAPTPIPPTKQRQLQNQPMPSNQLLRKYSSNSSSSSIIEMSTTAESSATSAAAALTASPTRRSMLLSKQSDRLPKSSANLGMERTEPEQKRRKKDVEHPKKLKKHSNNNDNNKKINDGKNNKMGKLPSQPSSSASVQMLLAVTSDGGGMPVSKTAAGKQSSSSLALPSCWNVLPMTQQQQPQSAEQRAEAEQRRVKRFMDRLKKSLNELDRESFTRNLVFTAARLNSDSVGKIENDFLRYMIRIELAKKEKENKIREIPKAARKEFRRNFVHTKMPSANPHFDHLFAAFKEGKYEDMAVLESPERRNKFVALCPVLADRPQLAQHFGRALALTQFIHVHGRLLCKYISKCSRPSAEKLLTSMADGLAGYSACVEPVLRLLANILVDVCKVKVQKQKALVQQPPPPPLPPTSVRSLRSRDIKHHQLQQQTESMAAPEPNVMDLVKALLKGDNDAMTMTNADDAAATTTTITKNSISPEQPLKKTQRRRPMVRASDEEEENAGGDQIGGGEGGDVDDAEEEQKKMKVEEEQEEVTNGRKRSSFGDSLYNVRAELEGDGGCHFYQLSVQAQLAILEHFAKRVQSTTVFHDHLKEHGIDEQHEAEQQKAALEQNLSNHRAQLVKLEKEIADNNVNDLAMLTRKESSNQSANLKKYNTLKRDIDVIVQQLDGMDKRCRILKINNKYRVVPLGQDRFHRLYWFFAGSADGQALFVQQLSCPSCAHSLEKKIDDDDDDDDEQFMRRLTENVEGRPCCCCAVMEEHWWHIRSRAELAELLDTLTARGLREHRLKRQLKAYRDLIEAGMMATIKAVATDTKAGRGGTVTPENAENTTKQRRDVDEAESTETSKERGDLDEADSSTTETTKEQRDKGRGREPDHTAAAEKHDNGDDDDDVLVLCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I675</accession>
    <name>A0A914I675_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I675"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7141.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7141.t1"/>
        <property type="gene ID" value="Gr19_v10_g7141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502242" evidence="3">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7141.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20156" checksum="09BE014575F6E167" modified="2023-02-22" version="1">MRTLPALIVYTALALALMENLTAALSEGEMCENCQKVLYHAFLYYRVQTTKRLLKHKLKHLCKRYFEYRRHCLITLLPKVDLIWENMEKVLDEDRASEPVSFKPYGICATIKECDKDHSPLATFGPEDGVGMLEAAVTTASSTDSNTTTATSSSWSATTTTTTADESESEAMLMMDFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6C2</accession>
    <name>A0A914I6C2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6C2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g772.t1">
        <property type="protein sequence ID" value="Gr19_v10_g772.t1"/>
        <property type="gene ID" value="Gr19_v10_g772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="153"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g772.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35986" checksum="9ADDDFDCE41E185B" modified="2023-02-22" version="1">MYEDTDTNTNRRYYASNAIFDGRHYSIVREFQFGQKRPTDGICSEQSTFVHTELTETGLYKFSLELHDNRLKVTGVGGSLYGTEPANPAQLVFQLVVWKWEANGDQNVFEHINYRVGAAIDEIIMSERFVLVRVLQKVVISSRNPCEPVCPFDVLKFVVGEEGQIFYVSYHFMCHISPKIRAFFQNNRPVNPGTGSFVLPQFTSDEFQKFLVCVTPECPTNPNPVDVISVLKLSHFLDVERVKHLCDLHLINCVEKTLVDRLVIAEKYQLPWLKHFVVGCVEDEHLQNFYRENYIRLGESVSADLMSKMSGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6F8</accession>
    <name>A0A914I6F8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Aurora kinase</fullName>
            <ecNumber evidence="16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A914I6F8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7195.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7195.t2"/>
        <property type="gene ID" value="Gr19_v10_g7195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="49"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="13">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7195.t2"/>
        </source>
    </evidence>
    <sequence length="414" mass="47679" checksum="91D6FB9A82BFC689" modified="2023-02-22" version="1">MNQHFALSTTTNKENLCPAVAPCNKIYDGIDYSECGRVWNEKQWTLSDFDIGRPLGKGKFGNVYLARDRKYRIPVALKILFKSQLVKGNVEHQLIREIEIHAHLRHPNILRMFNYFHDEKKVYLILEYALHGELFKVLQRHRRFTELTAAQYIFQVSDALNYCHSKNVIHRDIKPENILLCDDGKIRIADFGWAVHAKNRRQTMCGTLDYLPPEMVLKQHHDEKVDYWSVGVLCYEFLVGKPPFETKTQQDTYTRIMKVQYSFPSFMSPGARDVISKLLVKEPARRMNFEQVMKHAWILEHCNKGGNDVDSSTTSAASKVCSISLNVHQKSHISMTKFVLSLSSLSPSLIRSGLDVIPGDFANIDGVRLDMYYTHPPGRPHGAESRVWSPHDSPVYNGEARKLGYKTRKGFQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6P1</accession>
    <name>A0A914I6P1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EFR3-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6P1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7127.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7127.t1"/>
        <property type="gene ID" value="Gr19_v10_g7127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7127.t1"/>
        </source>
    </evidence>
    <sequence length="998" mass="110693" checksum="A6C6C31AF3537E55" modified="2023-02-22" version="1">MSHLCLPSNCCASCKQRYKRLVDSIYPRQPPFDAPLGANMQKLTFYSISHPEKLNRIGIYFIQRLTRDLTRQRFAEVKVTVDAMERLLKSCHGSPSLNQFIEGYLLMVQRLLETNNAHMEKLATDLFVRFSGIEEDSPSYHRQYDFFISKFSSMCHAQNGAYIRSQRFNGLRGLRGVIWKSASDDLQANIWEKQHMNKIVPSILFNFQHDDENDDLEDQGVDQSTGMLYNHYPDEPGSEGSEPEPRNLALQCLRELFQKCSFGSLKSVLEPVFIHFELHHKWDPPATFAIKTFKAILYSIQSQNSYFVIQELINQLELQPTTEPEVRVGMATVLARIVSIAGTSIGPLLLAIFNSLLKQLRSSVEFQQSRQCTDHETERLFQDTLINALGDFASALPDYQKVEIMMFTAASIPTITESNNSASTGATAAGEQIKWVATKYKTLYLATVFTDAFLKTLLQLQLTTDPEVRLIAQRIFHTLLDRHENQARLEHIQFVADLDIELQLSVEKCSRQDQLFMRRHIHAITSTLYRNVVQAVYGQQPSGPVGGASLDDQLDAVLCSIALLCTELMALENGNQMSAEKLANVHNLVAKFMNLFSCLLAIPALCQHVQQVIKAREKRAHPSLNIVDNAQKVAADVAEKLALQAYSPPAGRAPIAHMDSEDNELSNGETLTCRTIDGTALSSREKISTDRVGIVDLGAEPSMLFSSEIIFEAIQASNKCAQRLLQPFKPLALAQTLSATGSNVYLQNGSKLGGAAGFPNNSIISAFTPSAAGASSSTTSGGLMFSSPLNSSRSAQENDSNSSNTQLAEDGEKLNGAYRTSSVDAASVGSSSVDWSPPESRKHSRRNTALGGGGVQQAVALPITVEQLRIFANSPIDVAEEERLDQEKSRKVLQLYRGKTVKQLEEFLIYFVNQSFNFSFFVGGVGGGCCNCAKETHADQHHHQCCTTKTAPEGAETLAQTLHRLTQRHEEKCKVREFGQQGAAATIFDIKFPASFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6Q9</accession>
    <name>A0A914I6Q9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6Q9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7416.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7416.t1"/>
        <property type="gene ID" value="Gr19_v10_g7416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037691652" evidence="16">
        <location>
            <begin position="19"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="499"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="18">
        <location>
            <begin position="509"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7416.t1"/>
        </source>
    </evidence>
    <sequence length="714" mass="80359" checksum="4FFF22A9F65B64FD" modified="2023-02-22" version="1">MAAALLLAVFALLAQFEALFSEQQLRIGAVFRKEQDAHLVAAFNYSLHWLHNRNILLSDGIPEREAVFGIVTGFMEILEDSEDYYELLEKACRLINERNVHALVGPAHLHQSELLADLSAKLRLPFFSLVDPLAHHFLNPSDGNLVRENASTATAAEAEAVHLEMFPHTQLLEAIIDLVKYWRWSRVIVIYRQPERIRRLIVFLESDSLASIRFNLVNIEHDDFLGAAKRVKELEECGEMTNRQQQGQCSEFSRLLLDMDPHDTHQFLLAALKVGLVELKHWFLSTSLDLRNMDMELFRHNHAHFLGLDPVNSNPTADQNAHVPSLSVHHQRLLPDFDEFKQYIHAHATARDPSAGSDGLKMSEAAFLFDSVYLLSRTFASGANNSARNLLFSSGPTTAARCASGQHAHRPFEFGIQIARQVKQYANTLHGFTGKLGRLNHDGANSNFTFRINLLGYTGEIDDIGYWEGSAATPILNVSDASRAQLRRNVKVSNELKPRFRVTTILERPYVMLRTTSNDNGGGTDTGRNGHEQQNAKFEGFCIDLLAELAQDLGFTYTIHVVQDNKYGKDNGNNSWDGMIGELLRGEADMVMAPFTANFRRAEVLDFTKPFLSLGISVLYRIPEDYQPDIFSFLNPLSLEIWLCILLSICGITFGMYLVANVTPYEWNLNFSCCTAHQPHPAAQFSTVGAGGDKASTTTRIQLSNNYSFWNTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7A7</accession>
    <name>A0A914I7A7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM9 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7A7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7571.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7571.t2"/>
        <property type="gene ID" value="Gr19_v10_g7571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000195">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008853">
        <property type="entry name" value="TMEM9/TMEM9B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05434">
        <property type="entry name" value="Tmemb_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037989750" evidence="19">
        <location>
            <begin position="22"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="459"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="187"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="861"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7571.t2"/>
        </source>
    </evidence>
    <sequence length="897" mass="100125" checksum="F93C07E1D3BEFCE6" modified="2023-02-22" version="1">MNLKFVISVLFVYFFAHSTKANFEDTRCRCTCPSTEYFSSKNKTPAEHYRRYYTKTNLNSANCNTQAVVKQVVLNDVDASRLDAFLANCNCRFESRNSLLLKVVVIFVICVLLGLGSYMMYLGLPYLVVVEPMLRREQPFIPYRRHGDDDDDVCLNTFWFQDPSSDVSDTMVASDLDEPTMEENIFANPRTSGVEEASSEQQRPSELQMRSKQANQQHSGGTTLHERVLNRVASEQSKWKNSVEEQRRNVLDHSQMFSQMHRIRLASPLGLYIRWRGIHSFRRGRMMKTADAVGQTSTGSSDQAWWLRLIAPSRASPSPSTTDYEVFKQQDSIGESGTNSNKPVMVVRLADAPGGRLSTFLGRVGESVVIYVAKLVTLAVLFVGGCQLLLWYFGIKKVTVHTGGTSLLESLTDQPSWTTDKVDVTFEDVRGMDEAKSEVEEIVDYLRDPRRYTNLGARLPKGVLLVGAPGTGKTLLARAIAGEADCPFFHAVGSEFDEILVGQGAKRVRELFRLAKENQPCVVFIDEIDSVGSKRTNSAIHPHANQTINQLLAEMDGFEQNQGVIVIGATNRVDNLDKALLRPGRFDVQVTVSKPDLPGRKDIFRLYLDKIVHGDIHITQLAKGTTGFTGADIENLVNQAALKAAKEGAKEVNMRHLDEARDRVLMGPERIKGRLPDEEENRNTAYHEAGHAIVALFTKHADPIHKVTIIPRGSSLGHTSQLPEKDRHQTSRAQLLATLDVAMGGRVAEELTFGQENISTGASSDLRHCSQVAEQMVKVFGMSDRVGLRDFSLEPIESENGFRADRGPGTSEMIDQEIKNLLQQSYERVKDLLTRRKKEHLLLAEALMEHETLSKSDIEKLLKGEKLSKPPPPPKQQQNKGRTLAIGKKAKEEGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7L9</accession>
    <name>A0A914I7L9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7L9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8041.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8041.t1"/>
        <property type="gene ID" value="Gr19_v10_g8041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8041.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13884" checksum="D4D5D47EC7D55503" modified="2023-02-22" version="1">MPITEMNLKKLSAPLFREPLPASPSLSVVSSSVAGEYSTLRRNFVEQAGFEANVPRIMVIPRGRNGFVRDQKCFFDRFGVVEGANYVVKLICLHLGRICISQKIFLCKDLCVPLVGSFAYSLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7V0</accession>
    <name>A0A914I7V0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7V0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7444.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7444.t2"/>
        <property type="gene ID" value="Gr19_v10_g7444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7444.t2"/>
        </source>
    </evidence>
    <sequence length="242" mass="27761" checksum="85637C46501D8486" modified="2023-02-22" version="1">MPMPNKLCHTQKCIQTMSGPKITIAVAAIVSPFVTVFQLVSSVCILHSLKPSNRRRGHYTYYLELANGTRSRQMADVVYDERQEQIIFFHAFLIAFVLPGFLMPYLLWAVSRKSRHNLLVWWICWITLHNAHALMGLLTYSLNLAQIAIYNRELFSFGAHFCAYWNFFNICSLGSTLNTFVAPFTTFLSVYLLRFYQNLKGFPPMDVDVIAHLKVSLLKPVLDTKTSSFELLNAQRKSAQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I852</accession>
    <name>A0A914I852_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I852"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7620.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7620.t1"/>
        <property type="gene ID" value="Gr19_v10_g7620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7620.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25667" checksum="A9650555593AC84D" modified="2023-02-22" version="1">MDVSGEKHFIETSLVARLSIAHFFVSFHSFIANLMKENENEKRTDPANGQPLFFADGDWIGARELSFRRALCFAFRLCVATFLSAQLWDFLFSPIWMHGYLWALNQHAVSEQGSMGADKSAISILDQQLAQVGLWERTLHGGLSSLAVWLLLSYANFSHQKKSVWALLRLAFCLGMVSGLARAVQMRQRLLPCVHECFYGVVEVFLVGLCLTLRTPRGGYSKSGKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8C0</accession>
    <name>A0A914I8C0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SLIT-ROBO Rho GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8C0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8417.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8417.t1"/>
        <property type="gene ID" value="Gr19_v10_g8417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07656">
        <property type="entry name" value="F-BAR_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000112">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="552"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="855"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="828"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="864"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8417.t1"/>
        </source>
    </evidence>
    <sequence length="1237" mass="136470" checksum="883F7226AD9DD199" modified="2023-02-22" version="1">MASFRKASQQEFQHQIKEIRAQLFDQVKCLEQRTDVQVAILGEVNDFVKKKAELDLEYSKQLDKLVKSVMLKHKNEKLKRSNWALHSTCQLWQQLVDDAKEEARQRSITADVCANYVAPAVAQRSVALQKIAKKCREIGVLAQSEVVRVLHELHTAMKTYQHCFAQFNALSGQLQQAEVQRNKVGPNSSTRKQRSVQKSYDKKSEKYTSARLKCTRARNEYLLCIDAANASLHKFFADDISDLVDCSDLGMDWWLSLLLQNMITARKSACQVEMNALANLGSFKESLQLAADKQRFFESNHQTFMLPKRFDFRCEEAEHVGHISVAEGSLAEEFRQRHHQIRKRLDTLKAETEMGWQSMESAERQIRDLLSACTVVQVSEFGIATSADDDRRPSETVESELAKAYDAYMQTFSYYLYTANLVMRLEARADGIGNALNSAGPPADDRQQHSSPSRLTVGGSSLSSATGQISESLKNSGGGGGLTSVASSSITIQEQTELSERTDSLEWAQRYRKKRIGSQASTELTHPLPSATGSGGVTNTTPLWRRPRLFGGSLEEYTELTGEPIPLVVVSCIRILSQHALHHQGIFRISGSQLEINHMREAFESGEDPLRDVRDGNDANSIAGVLKLYLRELREPLFPFYLFDLLTDCAKCSSTVDFVNKICPLLNKLPRATYLLLRYLFAFLNHLSELSDENMMDPYNLAICFGPTLLPIPEGKDQVCYQNSVNEVVKNLIVHSDAIFNARVPGPRYEKYALEATDGGGTPAGDISAELELFVDDEVSSASVAVVAQPTPLDNWTPSTRQQQLHKRLSSADLPFPPPSPQFHRFHPQLQSPASASPPQQQQHYQRLPFLANHHNQQKQHQQVITETSSGGVVGQRDNSSSGANATTPSLMDWSLCSAASSVGGLPLPPVLCPTAVADVHYHQQQQNHQRKFLTTTNGNINNYCYSSSESGIADSTNGTATSPRPAVQQQQLVRQRMCGAGSGPNSSVDTITDNVADLYTSIHKGDHHRFPRHAMPTTASSVTTSTSSATTATQPSTVQCVRQQQQQQQQQSNVVGAVQQHQHKSPPVILRFGSAQPVPGEHRAHHHPPYPKEQQQQQQSGVSPPPYTALYGTKMMATAGRSPPITTSALHDGPSKSAAISPLTTAICDPSPTRRRNSFHDNMNSAAIAATSVSVVQSQRRAPLMMDKPSSKLTPTGQSAATDQLKQHRLEQVNAIDELLGKLSTVTGGGGADGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8N2</accession>
    <name>A0A914I8N2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8N2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7741.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7741.t1"/>
        <property type="gene ID" value="Gr19_v10_g7741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF133">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="182"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7741.t1"/>
        </source>
    </evidence>
    <sequence length="425" mass="49951" checksum="A5B090A080B13F10" modified="2023-02-22" version="1">MFPIVCSTAFVRSFVIFAAIFSKVLSVSEWNWDKSSIKRDDGGRKADERRNSMPETAPKKSFRGHKLLRLNPRTDDQLRWVHQLYSSDLKSSPPYFDLDFWQPPALQNGALVDLTVSQSDSLAFFDELKRRNFDYLLIADDLEELIEKQSQKGGEDSFWDDDGGRLVGEGPRGKEPPYRYDRYNPLTRIEEQLFRLRESNPRIVTLYEIGRTHENRSIVLAKVSAREHFPDERFRPYKGPAVWIDAGIHAREWIAPATAMLFLARLINGYNARDPNIRYLVESIDWYITPVLNPDGYEYSHTKNRMWRKNRRPAFCKQQYFNRICCSGVDLNRNFDWFWSTTGSSADPCHETYHGPSAFSEPEAMAVRDFLEEHLVKAFFTLHSYSQLWLIPYGHKRRNYPEDYTKIQVRKNKVVGMFLEYWLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I912</accession>
    <name>A0A914I912_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I912"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8017.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8017.t1"/>
        <property type="gene ID" value="Gr19_v10_g8017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000097">
        <property type="entry name" value="Bent, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="114"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="331"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8017.t1"/>
        </source>
    </evidence>
    <sequence length="515" mass="56789" checksum="7F721C5C394FEA8E" modified="2023-02-22" version="1">MPGAPRFTQKPSIQQTAQGDLLMECLLEADPPPEVRWQHAGTAIDASTRVQLTLINVSGNMYRANLVIKEPSATDGGAYKCTASNKFGESNANINLNFAGGEEQKASSGTTRGPTFVGKPRIIPRDGGALILMECKVKSGTRPTVKWSKDGAPLSMGSLYQDVFADLGDGTFLCQLEIRRPTAVEAGQYRCNIRNNQGETNANLKLDFQQEEAPSEGRRSKTPSRPGTPSKKHREGTPSERRRHKSKSREGSPRKHIRSRTATPTQEVESGSLKPPGEQGEKSREPTPKKIRREAGEMETLPPTAPKEKSRRSRSKSPAVQAGPEAHRRQPVVTEPLKSQIAHTGETVKLECELQCHTSTKITWSKDGKTISQSSEYASAFDGRVARLTISNMTETKSGLYKCLANSDFGETQTSAMVKWEMSEAEKTELEKKQKKVEKMELDTNGTAKQKKRRIVAKKEEVPEQDQMVPEKRVQIHSPSPSESGAASPKAGKYSGSRRSTQEESMHYFAKLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I925</accession>
    <name>A0A914I925_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914I925"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7759.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7759.t2"/>
        <property type="gene ID" value="Gr19_v10_g7759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="685"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7759.t2"/>
        </source>
    </evidence>
    <sequence length="733" mass="84118" checksum="F750521AE098A218" modified="2023-02-22" version="1">MAGPLSISQVDAIIEKVKQSSYQSFTENVSVDELHFLCETALNVLREEPPLVEFQPPAVICGDLHGQFTDLMNIFTKIGFPPDNKFIFLGNYVDRGKQSLETIVLLFCFKIRHPESCFLLRGNHECSAINRTNGLFEEIGQRYGQQHAQLLWKHFNQAFAWLPYAGLINKRILCIHAGLSPSLQSLQQLRKLRRQLSDPPNPSLELDLLWADTEPGIQGFRSNLRGASCVFGEDVVSNVCAKLGVSLIVRSHRPVRGGTEFFSDRRMLTVFSAPNYAGHVNAGAVLIVDENMNYVSEIFQGNREGVTVEPAEIQKFHSQWLRLPQSASKSRKELVPESIRRECLKMILDREASKLPSDEVFNDFVDCLEASEHVKLEEVEGKTLKTISFNGLMSVLGRVGKSVTNLLLPTTFFRAHFPEWDFQSECRIQVDVVVEFVSLKMEFVRYRIKMALYDPDSTGYLTREQFCNYYLKEVMPMVDVLKDLEETFQICYMNTVESMFFFFLDPKHTGRIRISDALVSGFLENAFSLQRNSENYDNWFSPEKTHEQNAIFQMLDSKRKNFLNRDDFKKHLDRAITQTFVDRLYEIHIAYNHLVHPASMAYFFKVLDVAENELCSCYNEWVAVDGAMPAFDDFCDQFFDMVKPTEDGRISLQELLDCKQGHDFILCLINYQEFYRYEMRDSESNAGLDQDSAVPLFGDMSDDETDEQESVPSTSELVKKIVDECNNNVNTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I952</accession>
    <name>A0A914I952_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I952"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8649.t3">
        <property type="protein sequence ID" value="Gr19_v10_g8649.t3"/>
        <property type="gene ID" value="Gr19_v10_g8649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="441"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8649.t3"/>
        </source>
    </evidence>
    <sequence length="872" mass="92080" checksum="4BA3331187B2D61D" modified="2023-02-22" version="1">MCSTQSDSPPPQQRPTLMSCVCTPSADDGAGPLCKMSPPESAAAALSASIPDPSSAVPDPAPSSPVFVLLALTETEEECHSPRPSAVRSASSPSASSSSSSSSSDSAIASSSLLSSPTNGVVARAASPSLCTSSSTGVSVLHVAHQSVDGGTWEPVGPVQHLRMDLHNAMDQLQKMANLVAHRAVLFCSREAIRQSIYPLCANAMLAQLAAEEAERCGELRQDVQLFSARLPLPSLFHAFVPFSLPYDVPPSIVPSSESAVEVNGGGGGGGGQETPTEPMECGGAELRRQLEERIRRMGAKLRERGESAVAILSRLDRVAQGYTPAVCSEMHVDSRCVVRARGLPWHVSDLDVALFFAGLDIPPGGIALCLGPEGRRSGEALVRFSRADQRELALQRHRRHLHARYIEVYRASGDEFVKHAVGTDSQAVRFALRAETAMAMIVRMRGLPFTATEQQVRDFFSSDGQPSGLLDQPGAVLFVHRPDGRPSGDAFVLFGDEQSGRRALAKHRQRMGGRYIELFRTTQAEVQQLFNARAIAQQNAAIAAAMNKLGAVVPLTTVQQNVLTPASPTTAPAALSGTAGAAPPAQQRVPQQRQRDCLRLRGLPYEAQVQQVVEFLGPHARQVLFQGVHMIYNSAGHPSGEAFIQMESEQAAAQAALEMHNKYMELGKKRRYIEVFQCCSEDMSLLLNVLPPPSPVNGLLPPPPLTPTGGPPALFPMSTPLNPLGAGGGAASPSPLLAAFPVPPQFLAFPSPAAVSNGDPSMGGGVLVAVSGQFAGPLVQQLYAAPPPPDTTGAQFAHHSAVPAEFWLRNMAALRNGAAAIATTAAAPFAAPTPLLPFHQHQLHTLPPFAAPTSISFAAAPTEVVAVQQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAG2</accession>
    <name>A0A914IAG2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="4">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8097.t3">
        <property type="protein sequence ID" value="Gr19_v10_g8097.t3"/>
        <property type="gene ID" value="Gr19_v10_g8097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="219"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8097.t3"/>
        </source>
    </evidence>
    <sequence length="2041" mass="229556" checksum="CAF47622A70CAF79" modified="2023-02-22" version="1">MPSKKQELRKQRIERYQRRTDQSVSPGSSQIPDSPLDCNGIAGGNEASQGTTPKMSALRISTPAPSMGKKRGRPPKAGNKGVSLTDTPNSTVAESATSSPCLKKEKAFEYDRKVIAEVVPSTPVSTKEKRGRPAKKKRGPGRGKTVDSESECSIMDESIVGSETMQVEEPLEEVDANLKLEKVGCTSGDVPEHIDFNVVQINFAVTRNFNCRIWRWAAIGLYQDDATSSGPRFIETCWNNPKEWLNDGFIAMYLAYLASISQRKVVVLDSIVFDAAVSRVRGSYRNYTFGFDASTPAEVILMPINFPGHWTILIHDVETGTFFADSLQMSILDLQKSNLIKGIIAEISSTTFESISIDYVDNVNLTPQNDGFSCGYFVCLLEMEDVQSTSKIVQSNVQLDDDSDDIMIVDVPPKEKKVEESIFFIDPSLHEQAEHPASAAMNAVLTQAELPGENQADELALIVESCQVQEPIAQANEVIFKRPKTPPRRSSRIKRLSNSLSRSPSPAVKRAAPTKGLKSTTPLTKRCHMVHKGWHCAAAAAKHFPDYSDSGKLGEKKCPHCGAHLFQHEDSNICCRQGRVELPTLNPHPGELKQLIVGDNQTREGKEFVRNMSRYNNLLQFASVSAGNKPCPSGGPMAVILNGEFHRRISSMQAGTTQTPGFGQLYILDPVEAMEQRRNNPTFTGEKITTNDEFVQGHKLNEKTLESLEKMIQENHPAAKAYKQAREQLQDLFKTQKPEELRFFRMTLLDARRAPTAVKDPKLHPNQIITPSTGEGMFAIHADPSGAPPPKGIWVENKQGQLNEIAPFSPWTDSLAYPLIKPMGDDGYTTGIKYAKPASRKRKSDVITDHLFDSDADSDLESCAADSDASSDAGSVASGASSVCGRFGKARQFVSLRDYCKYYLAIRDNDVAAGYHHILTCGGGLGQRWILDQAAKIDWQIATFLRRPDMDLRISTPRSLLLYLINQYNKQKARQNPNAQRKSVDDIGSVVRLSEKNVNSLQYWKKMYEDCNTIFARYHDAKKARLFITFTNNREWPEFKQNLYKNGQVFTDRFDLWMRVWCSKIAVFRQELYEKSYFGTIIGSGESMEFQGRGGPHAHIVAQTDLDAIPEVIQEYIWAHIPSLPDKDDDTPIAQMHREIRELIHMQLHRCSDTWCGPKDPKTGRCKKGFPATYSKCTILHPDRPAVYFRPSPAEGGAQIEVNNLIYDNSHVVPFNPFVLIRFRVHHNVLFAYGNKANIKYALKYPFKGPGHCYVECKEESGNKIGIDEPAQYAKMNFRGATEAYAVVNSIAYVRLSHHVVKLSIHLPNQQPIVFRAGQLVSKAQQIEQGDLPETPCSAYWKQWQNEWKDEPEFKDMLFVQVPERFRWVNDKWVAYKRKPSKRPPIGRIVPVPPSDPERFALYQLMRHYPGDPDHLKMANQQPCTSFIEAAIKHGLLEDDRVWDKTLEEASLSRWPDQMRWLFVSILVFGQPSNARELWDKYKEHMYHPHGIASKAQRLAKELQALADIDWRLFNFGFSCVHFGLPDPPNSIAKNTEKAVEEFFFGDDDLNVPPGLPNANQPQQSQTPPLNSDQQMVFDAVVKAIQTDPSDQSVPRRLFVYGDGGTGKTYLFGQIIRRLRKAPYSNKVLATASTGCAAILLPYGKTAHSTFRLGREVSLDKLPSIPLESFFARRIREAQLIIIDEITMLNNTVIEVIDRVCKEMAIRQHKELLFGGKTVIFSGDFKQSLPVVPHEGLAAQVAACFQTSPLFGQFTTMKLTINHRLGKGQQDYMKMCRQIGHGETGEFFWIPPQFLVQSSEDLIDFVYPDFQKLLGNDKELLNRLILAPHIQTCDEINELMMDNVPGQVRDYLSTDKPLDERPLDIDEIESEVAALNQRTDSGMPPHRLRLKVGCVVVLLINKSDREGLINGTRIVIEELGEEKITGRAINGTAVGGQVRFFIERTRNVYEDKAPGGLKYERLQFPIKPAFAMTILKGQGQTIRTVGIDLEREVFSHGQLYTAFSRASDGNNVRVYAPNRETDAQGRARVLNIVATNMLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBS7</accession>
    <name>A0A914IBS7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBS7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9147.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9147.t1"/>
        <property type="gene ID" value="Gr19_v10_g9147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9147.t1"/>
        </source>
    </evidence>
    <sequence length="445" mass="51208" checksum="8DD06A20D5E3A5C3" modified="2023-02-22" version="1">MDFWDQPNRNSLSSAKPIVGVQKHFCLKGAGAVSAPVEAERRCAVCKNICISTYYGVLCCSSCKQFFRRTIINKRHWKCINNGQCTVDEPQSKICCKACRFDKCLAVGMNWEAIQVLNKSDLANIFFAELVERQKQLRIMANDKTMQTLEMPIVNSDLTDNKLIKTWLNIEKRQKQIFEFFFNMPDNYLQFATNEGMQNYLETGSNILGQVHLFPISNLSEESYWVCSNEHPLILKLIAVDRLLIMGLAKMMPIFNTLTLSDRIALIKHMILPVNALSYCVYSLQINSTTWKRCRHLVEAMACHCKVPEFKNDGRLYQLAEQAFVHSMQPFLRIKEAISAEEFVMMQAILLSHSAISELSAQAQQLLYDESVRYTKILLKFEQHRLGAAAGAARFAQCLQLIDHSIYVARHLEVYCTYKEMFYYRKSIDQSMKEALISVSMTRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBY3</accession>
    <name>A0A914IBY3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8788.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8788.t1"/>
        <property type="gene ID" value="Gr19_v10_g8788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8788.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15097" checksum="452E5DBC629F4482" modified="2023-02-22" version="1">MSEFDLSGPAIFQDVRNYRRFSTRNHSSKVGLFAQSAPTVTSRKRSQSRLIGRTEEIQNCSGAIGETAKNQKAAEEKKHSDSLIQLKFFSFDKFKEKCKGFDEDFKELENESEGIEKKLRRLARLYPDEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC14</accession>
    <name>A0A914IC14_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IC14"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9218.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9218.t2"/>
        <property type="gene ID" value="Gr19_v10_g9218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218728" description="Serpentine receptor class gamma" evidence="9">
        <location>
            <begin position="21"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9218.t2"/>
        </source>
    </evidence>
    <sequence length="756" mass="86610" checksum="EC9643A35B135DAA" modified="2023-02-22" version="1">MWTLFLSILLSITFCKTTFGSSHEVSQEAAMAIHSNEIKPINGRKVLQPPPPPYTEDDIRKVENEVKYETDDRNSNDWHYGIERRMDMPMSEASEVYYDPIFGQSVVNEKNMRRALKNERRKNRNKIGMVDKKHHKLALHSMEKHRQISQYAQDVDGKVDTLHADHVATRKLAQATHGRLGNVKSALDKHKAIADERLKRYSGELKEKDGRLKTIEEAVNGQQQQADENMETIVKQLGKQAMHASQVRDKIGGVLELHGKHIDKTSNTVQKMKTRTKHLYTSMEVQGGEVDKLNTNIGTVVEDVKALKQVTAAHTAALENVALHDNEMFGKMIESQQMLTKHMLESNKQVLEVLADFAHQLDNKVLNALDNANARLAQAASIGDHQMSKLNVNLNVSRNPIDNVPSLAAQVQHPLFLKKHDPRREQYENEQREANVNNNKTNEHGMDKPYTEELKSSTDESNITYEDAPPKKKRRAQQIDFDHERIVSKDETEVMESHRKVFRTTFYHLFCIRGIFDILLLANSFYGNRLPTMFGRALLPIYRELPNWALASYYFMTSFAYQITNIATMYMLLNRLTAIVLPVTPILDCCSLFQMDATLDVKNGSNFLISEMEPLKSLTSITFMIVCFLINIVTFIAYKRFKQTLGSVQNFDKTEQKLLVYTVITFAGHAILALYLLCVTVWANNPKYVAIVYILYPCVNDIFNLGLSSWPLLWASSTFRGHFINEFYLLKSFKNVEERNTFKTPVFKIEQSPNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICL5</accession>
    <name>A0A914ICL5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICL5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g865.t1">
        <property type="protein sequence ID" value="Gr19_v10_g865.t1"/>
        <property type="gene ID" value="Gr19_v10_g865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g865.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11386" checksum="B78065209C01B577" modified="2023-02-22" version="1">MSRRKCPRRKCPTRKKQSSKVEALRQQLCAWRATGPSVEWSECRKSQCRMEAAHKMKELGSRGGGKTVFWHFGWGQLAHGIALCMVDRSKDGAREALHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID74</accession>
    <name>A0A914ID74_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID74"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8822.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8822.t1"/>
        <property type="gene ID" value="Gr19_v10_g8822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36519:SF9">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36519">
        <property type="entry name" value="FIP (FUNGUS-INDUCED PROTEIN) RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8822.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="34860" checksum="ED238A143AD8DEC4" modified="2023-02-22" version="1">MPSLADQQKPYSDSLRHIGRMPHPPPSVQRFLLCRCPFPSFCCTSTVRRPFLLPSMRRFALPFFPLLFLFVPSGIGQYYGSNFLSALRGYGTDLCRFVSCPLGQYCINGVCQVNSVASGLYGGGYGSALYGGVGAGAGGSLGLYGAANKLCADTVDCYSGQVCLAGRCSFQSGGYSTGGLGPAGYGVGYGGNGIGYGGAYGLGMGTDLASSSLYSPYGYGGGGYSPFASLANRPSGLLSCTLMQDCPNGQICVNGFCSESNVAYGGSQMLKTPPNCASGAICPVGYYCMGGLCAKDLLSQTSTCSLGFVCPPAQSCQFGRCMPSTSSLMYGKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDD4</accession>
    <name>A0A914IDD4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDD4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9182.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9182.t1"/>
        <property type="gene ID" value="Gr19_v10_g9182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF35">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9182.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12659" checksum="F4B028535778E7EC" modified="2023-02-22" version="1">MAMSSIPIEHDAASQWDWPLQHTDGVVKVHNTKDKFEVGLDVQFFAPQEIEVKVSGQDVIIHCLHEARKDQHGSVKREIHRQYRLPNDVEPATLKSHLSTRGVLTLTASKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDQ2</accession>
    <name>A0A914IDQ2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamine-dependent asparagine synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914IDQ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8948.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8948.t1"/>
        <property type="gene ID" value="Gr19_v10_g8948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="7 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="17">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="530"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="341"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="15">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8948.t1"/>
        </source>
    </evidence>
    <sequence length="608" mass="68387" checksum="8D2FD5E461AB0332" modified="2023-02-22" version="1">MCGIFAIYHPEGCAKFSVTRAQELSARQRHRGPDFHGLYQHPGNGNILAHERLAIMDLSCVQPLRGTTEEHQVIHNGEIYNWRFIRDGPLAELCFSTTCDSEAILKLYEKMHDQPEFEHELCLALDGVFAFAVIYGDEFMAARDPIGVKPLYWGTDAGGRKLFSSEMKVIEDSCVEMAAFPPGHFYTPRLGLVRYYEPDWFRWEMATGPADLLALRHCLIAATEKRLMSDAPIGVLLSGGLDSSLISTIAARALRGSDHPLRSFSIGLDREAPDAVAARKIAHFLGTQHHECYFSVQEGIEVITQLIWHLETYDVTSIRASTPMYFLSRHISKMGIKVVLSGEGADEIFGGYLYFHNAPDDAEFQKETIRRVNRLSTADCLRADKSTMANSLEVRVPFLDKQFLALAMSIAPAHKRPKMEPGKTERPMEKWILRKAFEDKDDPFLPDEILWRQKEQFSDGVGYGWIDELIDHCSAQISDEEMANASAIFPHNTPATKEAFFVRKIFHKHFPSNSATQTVLKWVPKWQKNEDPSGRANAMHEQAKVEEAEGTNNTTTTTTTTSTTMDGHCVGGHPEECKQKDRPEEVGSDLSPTNEVQKGTFGERCQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDW3</accession>
    <name>A0A914IDW3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDW3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g899.t1">
        <property type="protein sequence ID" value="Gr19_v10_g899.t1"/>
        <property type="gene ID" value="Gr19_v10_g899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037225887" evidence="2">
        <location>
            <begin position="32"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g899.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="20244" checksum="38A788C4FFA4973B" modified="2023-02-22" version="1">MQQQQQQLGQQSKAIIFFLILFAAHRDAANGVEQTQLNVQHAARTGTADIGAGAAPTDANAPGTTASVPTDAGMPYGNASASANETAEEPCPAPIPARQAPPPPLPSLPALPAFIALPPQPPQAVLRPAGIPLIGTQTTCRATGIAGRAHGARTASFGSAIWEELFGGGEAPPPPPKLFAVEPKCNSRVLESAILEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE59</accession>
    <name>A0A914IE59_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IE59"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9392.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9392.t1"/>
        <property type="gene ID" value="Gr19_v10_g9392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002104">
        <property type="entry name" value="Si:ch211-266d19.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000538">
        <property type="entry name" value="zinc finger protein 853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9392.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16495" checksum="1FBBFCA147E0F200" modified="2023-02-22" version="1">MLTHTGVKPFQCTECAHRFSQSGDLKRHMLIHTGVKPFKCAICGHRSAQAGNLKQHMLIHTGVKPFKCAICGHRSAQAGNLKRHMLTHTGGGRKFKCTKCAYRSARTGDLQRHMRTHTGERPFKCTDCHKAFKNSSNLKVHLRRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFH2</accession>
    <name>A0A914IFH2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFH2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9759.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9759.t1"/>
        <property type="gene ID" value="Gr19_v10_g9759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9759.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12356" checksum="BEB04F213B6A7D2E" modified="2023-02-22" version="1">MVELYMLRLAIQRLTARFFYGHEVEGCSYTANGRPFIVGKPLFGVGDIVGCGVNLATRQIIYTKNGQRLDTANLFVNSAAKLFPRVMLFNPGDKIEANFGPNFKFDFADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IG15</accession>
    <name>A0A914IG15_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IG15"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9906.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9906.t1"/>
        <property type="gene ID" value="Gr19_v10_g9906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9906.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14109" checksum="7CBCC2395BFF7EE1" modified="2023-02-22" version="1">MAENFVAEQGQFPCGLLSQGLQCPRAFNTQASRNVHRSRAHTREERGCAYRCNYCAHGSATEYVFRRHSQRAHPLLFTPPRLLEGLVFQFRPGSVVGIGIDAENNLEIDGTGISPGFFWEMPPPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ26</accession>
    <name>A0A914GQ26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQ26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10292.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10292.t1"/>
        <property type="gene ID" value="Gr19_v10_g10292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10292.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8356" checksum="AEDA909ED1CE2293" modified="2023-02-22" version="1">MWLKLIPVRRVHRSLQKLSKKLLKRESEQKRAQLWRKRKTEENKFYLAANASSNRRASRLNERRRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR57</accession>
    <name>A0A914GR57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GR57"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10420.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10420.t1"/>
        <property type="gene ID" value="Gr19_v10_g10420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10420.t1"/>
        </source>
    </evidence>
    <sequence length="558" mass="61513" checksum="037ADB037C9D65D5" modified="2023-02-22" version="1">MHCSPSSSPSLLPSAASSALAMPPSSSTLLPSSVAVTFFPSTAQVGPTTADEMSANPFLSHKRRRGHSPPAAEPQQSFRRLEDENISSGGHLAHANFIAIPPTPNAPREQQQNVNIHRRKEQQQRHSTGGKEVGRDGEGLPVVIQQKVFENYHLVAYTLVIVTYLLAFCEYLYLRLLSLIFADPLVYRRNCEKHHYEVVYRNELHFASGCAVFLVTSVYQLVCFFLLTVSSRFMEVKRTYSHVISIEQRLRHELVFAVQRTMFATLYPTFAIYLMCSAVILCSIFYMVGLRDQIVHVGSLVLIYLFDLFVVLYFLAFPVLGVLFHPDIDCRARLARRCCWRNRRATGADQPISVGGKSMQTTAASEEHTGVHPTSDGTGGFTTAIRNTKIAGVTDKAPRTKPSGGVFAPGGGAVRSVPAALETMARGDAEGGSVCSVPKIQQPIAQLVSAKNYGSLERRPRRAIMAENADSTLPTGTSVRIRAIRQRRRGDKYRRLREGSDESAECRQGTMDKAKTEAQERGTAEAFGTEERKAQGKRWHAADSGDGEAWEDAGTVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRI1</accession>
    <name>A0A914GRI1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RIO kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Associated with late 40S pre-ribosomal particles. Interacts with PLK1 (via its N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914GRI1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10633.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10633.t1"/>
        <property type="gene ID" value="Gr19_v10_g10633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000307">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="22">
        <location>
            <begin position="66"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="407"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10633.t1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60356" checksum="2E75A24AE581C1E8" modified="2023-02-22" version="1">MGKFNVQAMRFLDAQHFRILTAIEMGMKNHELVPLPLISSISAIHRGATARTLNDLTRIASVVYERGKKYDGYRLTTLGYDFLALRALCARGIVGSVGNQIGVGKESDIYVGGDPEMNDVVLKLHRLGRTSFRKLKEKRDYHRRRHFCSWLYLSRLAAAKEFAFLRALHAHKFPVPKPIDCCRHTLVMALVSAPTLCHITELRDPAALYDKLMELIVRLGSYGLIHGDLNEFNIMLNQDESPILIDFPQMVSMDHLNAKFYFDRDVQCVRTFFQRKFKFEANKWPIFGDVIRRYNLDKELEASGFTRKMLLDLNKAYDEGNFDAHLDGDDDSTVEDEDERKEQFDEEERDAFEQEGERRNGQLQRSDRFQKWLADARDELESLDIRESQLSGEQLEKMFGTLEEQTKTFGTDEEEEKEVLESPNDPPNNELPISGEEIKSAERIDDQNKKSKKGIPQVTAFGSCSVVSGGSAVISAEEVRRRLMLEKRKVRKEKLKVKGQQNAVRRGRQQNQALIREYAGWDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS37</accession>
    <name>A0A914GS37_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS37"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10756.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10756.t1"/>
        <property type="gene ID" value="Gr19_v10_g10756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10756.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9198" checksum="47362179A78F3C41" modified="2023-02-22" version="1">MRIMQHSCPTLKHTDDPRGDGWMFMRGCGQNDDGNEQEGAADDRPNGLRPKFDELRRKEETGKAHSTHWRAFIREQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSH3</accession>
    <name>A0A914GSH3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UBR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g10889.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10889.t2"/>
        <property type="gene ID" value="Gr19_v10_g10889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14423">
        <property type="entry name" value="CUE_UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000009">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024725">
        <property type="entry name" value="UBR5_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11547">
        <property type="entry name" value="E3_UbLigase_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="1118"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="905"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="967"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1580"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1797"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2021"/>
            <end position="2045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2071"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1604"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1619"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1668"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1741"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1807"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2021"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2093"/>
            <end position="2106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10889.t2"/>
        </source>
    </evidence>
    <sequence length="2323" mass="252877" checksum="3F5988B3D9FCA7DC" modified="2023-02-22" version="1">MHFFPLNLERIPKLSIISSVMGDQKQLFLFGQALPGNECGLLERMRECAEKRNKSNQQVTPALQSIPADRIKQIAVGSTHIAFLLTDHTIARLSFEIVTNVVESLVPSDKRDDTEPYVATPGAGSAARSASSSTDPASVAAQAAVNAANRTAKIRRIMMTRPGVRSGGFCRTGVIIDRNRSNRPMIPASSVPEELIVQCQVVLQGKSRDVIVRELQRTNLNVNEAVNNLLSRDDDEIEDLDETGEAYLHEELLSLLDAGLRSDGGDGYEYVISRDLARRREDPKGKDAGKNNEGTGQTLQEHFVFGDTLEIWGKKVGTNFPMPPGVEQFKKIASMNAELLALADDGQLYGWTWEKSSAPSIAPHTANLQLFGKTTNEDNKIVDIETCALRAVVLTQSGQVGSFMDASCGRKLADAFLEHLTDVPEAVERMFCCTLFSAVLSKSGTLYWRGVYPFTERRKLWEKARSKKKQVTSSSNDIVVGSEVRTKSTPIYSVGSVAVNFTNGLPMIGTLYEDAWTLNETCRFRVQTPENYDALPIGNNEKEKHREKRVSFSLAVGNRKRAAPTASDQMDEGNNGGGEGVGGGAVVAQQQSSKESAWAIRDVVFIHEESVNDVSIVKIVDGAYCGVVFKSTLDRLEQDGGGGAAPFDLSKLSIRLMRKDDLVPITSASIRLPSSVKRIISLAVDGTGFRILCVKNHQRIHLIRVSCLGKLLSDHPMPFAQNALCQPTEGVVEPYLPSVNNYGDDNLLLIRDSTGAFQPLLRNAVGGFQELAYTSLGRFYLFGMGIRFLKSPADVNLPSICTEPFSVISNKNAKGQAVSKNVNRMMLIVALIAPTPHTTTPTTESLMQSVLNCDLNSVRNILQKLSSDSVDLDERRNVAHERIEGNRNIFHVAVMNAFAKTNRDQADVESAGGDTADTSSALSRVSKWAEKWGDSSEADSARMRKWQEMLGSSGNSAPTTRAKAHQLQAAAAAATKDGPRSSNGGAGDADEKDLWDVAISKADDEKTMATFSPSGSPSKKTIPATPKERQANGIDIVRELCKSAALHEHFVELMQQRDVNGQTPFQCAINFRAYTAAHLLWETTTDLRDWSQDVVDIVAPTCAENSDESALFALCANDTCSYTWTGEEHTPQDIFECYSCGLVDTLCCCTECAYTCHRNHDCKVKRTSPTAYCDCWEKFGCRALITGNLVKREQLLNLFLQNGKLVSKLNARGEHLLLFLVRTVGRQMFEHESYTKRTKRPVPPNNAVNAAGQRIPEHDLDPPKFARRALEIALSNWEVVKSLLEVGTKKAPIEEMQISESAFHLGEQHGSTHLDKFVFTLLAFCDESSLDTLLNLLIRQANRKNVKEPGADVHTFISRFVRSVVRLFVLVILISPNAVRTLLATVSENIVKAFVPIEPAHSDTFGLSGSAQQQQFVLSSSVPSASAAGGTSSSIRESLQNYRAVAISGVLSLVRASLPGLSGLSGAADKRDTKKKNAISFVLKCRRVFQTLLSYSLNELIGIADTLVAPLRHGIVKPTSAMIANEDAIELIHKHLNTEQDLSSLLKEVVEGGGNLANMMMTNGGNNRIKKLVEMRHNETTRPAGTTGGANDGSTEQPTHSDDEISNEEDEDDDEMENAPNQSYHRARENSSASVDRLHRERTASGGGRRGVERQTSSQAAAAAAEPQQEEGNEEEQEMNEVAAEDEHDEEDEDASEHEMEEDEEDEPYFDVHDDDDDDDDEEDDDDDASSNPSDAEAGDSNDTVPVMQPSTTSAEGGGAEGDVRIELVQPDAATTSANNAVDALDRFSAALAAVDGTGGGRAASGTEAASAPRRPAEATPTSGINNEGFGVTSATGRNAGLQQQIDQMATIDGVFREPTLEGSSSSTNRLWRVGGTPLETAGGAGTTAAAVNAPGPNSEAYIAEDYQYLQSNTSTQLALCYSILVKLADELLVQLMCHTKWKQQLCRVKGISSFLDIDSVLYPEFKHLLTESFEPTWNWLHIIMDRTEAQLKYSQAISQSIVGPMVSPLASAEREEQRAAAQLAAVGTGTTADTTQQQPGQPRLASRHIAAGVTTVGAVAAAAAVTGDTTTQRRFRKKGNAGGGGLGRKPDGSAANGGAENEAENSTARTEFFTYFMSLLRSYSAESGDDLPVLEYNALRNVAFVAEAYFFHLIFLGQLKQLELENGIGVVDVQNGVGGDDIDDNEALMEVDGTNKIINEGHARRLRRFYRRSNSISYPTLSTAEQHHAFTFTAAEALPLAIRSHLLSADAERNALFALPVPERSRVGHKAIATKLGVQFPTHQSLSRLPVQYSEIVHRLSCHQQRDELGQEKQRSTMMSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSK1</accession>
    <name>A0A914GSK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10824.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10824.t2"/>
        <property type="gene ID" value="Gr19_v10_g10824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10824.t2"/>
        </source>
    </evidence>
    <sequence length="203" mass="23606" checksum="606A8736C516E12E" modified="2023-02-22" version="1">MKLNVLQIIYFCLITYVFTFPNDLFDELWEKNQPEPQANNNSIESQPKIKVESNEEQFDGRWQDESALKGNVKAEHEPHYEAVKVEDGQASNTSDHHKKIGDDDENWSKDEDNSAPSADDFDPENSKKHFSDQNNSTDQDESFDEQQNDLACSVPVPRILNLFLFLCCSEILEQNRTEQEQNRLSWNSKTLLPARQFLIKFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTY1</accession>
    <name>A0A914GTY1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTY1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10735.t3">
        <property type="protein sequence ID" value="Gr19_v10_g10735.t3"/>
        <property type="gene ID" value="Gr19_v10_g10735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10735.t3"/>
        </source>
    </evidence>
    <sequence length="952" mass="103082" checksum="C795A2E665E57F39" modified="2023-02-22" version="1">MSRGHRSASNSNTTTSANSAAAASSSSSSNSTQQQQQTPRRGNKTLGWYLGDKLNGGGGANANDGNSGGGGDSSFTSNNSQMAPQSKLGYQQNRKGSLVDTTTPNSSRSSTKLADDQQRQQNNNRMGKRHLQQQKLSVAANNNNHRPRANSSAMGGGGGKKTMLAPFGGMVNSSMAESNNNLGTAPNQTNDLAKQTAAVDQSTQQQQQQRIGKVPNNAKEDYWYYDEVSDGFYYEHSGTRGWRKRRPEWGTVEQMKGMTAAATTEHCSKRTTDQQLMLQQLGTAAQQQLIMKTLEARTMPSSATNMPSLLAAPQQLSKFAATQQSPPDHLVSPTPSTNIKYYDPATDGFYYEMASFDGWKRRQPQAGGVVTADGTSPSQGGTSSSSLSYCSPLLGGGGCGQSQQTNTAQQQRQSASPGGGQQQQKAPHRKIQPLHYQAYQQPAPQLNPMELQEMILLAQQSQQHHHHYRSVAAAQPCFCSQLRCCPSSTGVACCCDIAAMAAQLVLKQQQQQQKMMMMEQQQNNFDNNNLGNEMSTEFNKSSSTNNIRSLLDMDTKPSLLDAFIADDSQEQQNVVQPTLVRPTQRQQQLDNNDGASLKLPCDKWDHHPLGGIVPSTPPQQKRNTERSSSIITTTAAVAVNDGSNTTTTALSTGSFEEPYEFYWSGDDASSEVVPLDTNCGKQQQNQQHKMNNNKNEQSSIEVPFTLSTATTTAASVSSVEEDEMYGWGMMDEYMTEMMGKTVISSEQQQQKIAPIGSEANNHYGSGSKKRPSSLKLTCTKPMPISGCGIGNIVNASTTAYEPISPGEILLNGSGVDERQLNNNKGLAQSPAVSYLPYEFNVDQFIADLPMPPSMSSSSLLYNPNLALSKNSNSLCTPLASAPTMSYVVEQQQPITADSPLFTPIVPSIGCGVGSGKDPWKAYYYGNGSNVTAVHRLQQQQQMLNGSNPWAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUA1</accession>
    <name>A0A914GUA1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Interferon regulatory factor 2-binding protein 1 &amp; 2 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUA1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11397.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11397.t1"/>
        <property type="gene ID" value="Gr19_v10_g11397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022750">
        <property type="entry name" value="IRF-2BP1_2-like_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11261">
        <property type="entry name" value="IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like zinc finger" evidence="2">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11397.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="23237" checksum="9A96F41DC9D9E319" modified="2023-02-22" version="1">MQSISATELAALNMQQQQQQQQMNGNGNAQAIPDGQNQQSIVGNKRISTSNSQQPQQRLVGSMPGSAFGQSTGSGSNSLGVSASASSFLLRNSKANCFLCDLPRMPWAIVHDYAESVCRGCVNYEGAEKIEAVIESARRMKQIHSALSAGLCPSAISNTIPLGSLDLLNGTTSQLKSHSFTTHSGQQFPVNGSGIGLASTAVHVLLQRTAPTVTRHRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUP5</accession>
    <name>A0A914GUP5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUP5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11373.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11373.t1"/>
        <property type="gene ID" value="Gr19_v10_g11373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF283">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11373.t1"/>
        </source>
    </evidence>
    <sequence length="462" mass="48978" checksum="EBB89397D3C7F875" modified="2023-02-22" version="1">MLPMLIDELEELNEMASREGKQFKVLADEIWRDMMRLQGRPRGEWRQFRDRPSSPSSPVSSQQRGRRELQMLPGESRGFLDRLVRKSYKGRQRMKQGEGGPIVEQYQQQKPSNWEMYTKKTPFGGIFATTMLPIVPQANALPPVTVSNSPATTTTTTTARTTPTKRTYAPNGIAFAQGVSIYDEDASLLRATTTTQSNSGPRKQQRVTPTKCAKGPPGYPGKPGHDGIPGVPGSHGKKGESGDAVQRQFENGASRCVVCPAGQFGSPGAMGLPGENGENGASGVPGVAKRAPSGAPGPVGDVGPPGRDGTVGIAGKPGSPGTKYMKGKPGPKGKSGQVGESGVPGDDGIDGSPGSTGEVGYRGWPGEVGPAGKPGSIGLVGIQGIPGAERHYCNCPVRSSQLMRLKDQPGGVEGNFGRWKGRHPNQLLNEFEKYTRENEKEKGPAQKGQDKARTAAGILETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVJ6</accession>
    <name>A0A914GVJ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVJ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11733.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11733.t1"/>
        <property type="gene ID" value="Gr19_v10_g11733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016576">
        <property type="entry name" value="Ribosomal_mL63"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14978">
        <property type="entry name" value="MRP-63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11733.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17590" checksum="82FFB2FC4A553F58" modified="2023-02-22" version="1">MKLTQLLTKRIVCLNKHTWDRRVWEKGYYGPPLPIVKRTGRPPRVVTDDDVSEVRGALMREWNVMQWLANPYLNAEKEAPFLARHGDVVDEWERHTVEAKQRKMPSKPKIYNKVTGELEKRRGNVGNLLHAHRTVEGDMKALLRRNRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWI2</accession>
    <name>A0A914GWI2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWI2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11044.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11044.t1"/>
        <property type="gene ID" value="Gr19_v10_g11044"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6773.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6773.t1"/>
        <property type="gene ID" value="Gr19_v10_g6773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11044.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6773.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10660" checksum="893A3CE4015166B8" modified="2023-02-22" version="1">MAETELVPDGVGPKTELAASRLERAAFYKHARAPRCQALIGCWTLANPNMKERYTTGLISTCSTSSARKPQHERAMIHYRTNLNMFNEFSSQTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWJ1</accession>
    <name>A0A914GWJ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWJ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12.t1"/>
        <property type="gene ID" value="Gr19_v10_g12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="130"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34710" checksum="4EDC07A8CE4078CB" modified="2023-02-22" version="1">MPSLMPLFWRKQKKVELLRKLLTPSALHQAIKADPNGIRLLDCAFVPQPRPASYKYGNFDPPKQRVSENLLPWAYYLGQFDHYPREIFERYAQNFGLKQRPSVGDLWTRIVLGSVRFAGLLAGGRSQCCGISRCKHLDVRSQTQFEGREYVFEPLLTTAHRAGAINICAMNFVNTEGTFKSSAEIRELVQNSGLVIPAKAGKKLITFGNTGMLPSMLAAMLHIEYGLQIGDLCMYIGRRMRRQKVKISRSEDLGHKFLEESSRNLTSKSRRRLAETFHDFKQTSLWAHVARSAAFEKFSPVTRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXC5</accession>
    <name>A0A914GXC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of microtubule dynamics protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11255.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11255.t1"/>
        <property type="gene ID" value="Gr19_v10_g11255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF20">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11255.t1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42413" checksum="E2E871DC5D7A656E" modified="2023-02-22" version="1">MDSKSAVVGTGTIIIVVAAAGVVTTIQAGIIALLYRKCAKLTRKLQELQRENSQSVLSLRSEIVGLRNIVNLLERRIAESRAGLFSNSAQDSQRIGIGRVKSVNSVSEGEYADAVDDPDFFRSSSKMERPKVTAAAAEREYLEHFDRLHETGKHSEAYDELVKANRESDPEFLWRLARACHQMASLLEPKNPKKKEFLDEAHRYATAAYEMREDEFNVVKWMAAVTGSRTDFLATKERIEQGNLFKDLLNKALAINPEETTLLHMRGRFAYSVAGLSWLERKAASALYGNPPEGTYDEAIADFLAVTQHKPEWLENLLFLGKAYLAKGDKKSALLHLEKAVAANSCGDENVEEESEYLKEAKQLDQIIRRNYKTKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXH0</accession>
    <name>A0A914GXH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12102.t3">
        <property type="protein sequence ID" value="Gr19_v10_g12102.t3"/>
        <property type="gene ID" value="Gr19_v10_g12102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="959"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="982"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1026"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1063"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1095"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="516"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="962"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12102.t3"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125580" checksum="6453EC63C7E9BF7C" modified="2023-02-22" version="1">MAAIGPIKSAENDDSSDEHFKLPRRLKRFRKFASVEFDGEIFMTPQDFLDSLTLDEPSERVFRTVLSEHQVRKMVGLTPPLRKGTHKMFRALGDNGIISYAEYLFLITLLTKSHDSFNVAFLMFDEDDNFQIDKEEFFKIQFLITSGARPSATGVSREVFDQNGNECVVNSDFASPFVPVGGFFQSLTDEKQRHFPSPFVSVTFEHLISSNVAFIRTRAERLKKDSSRNSKLAIYPAIMEEATEAMRKRETTITIHLFGRRGQNTLSFDEFQSFYHRLQREIIEIEFKEFSRGKDRISTVDFARLVLRYSLLHREEQSPYIRRAYERSEYNEEGITLQQFEQFSMFLNNLEDFSKAVRLYSLADIPVSQSEFIRAVKCSTGFSLDSGLVSVLYKIFDANADDKLSYREFIAVMSDRLSRGHKTQRTEQRKLHSDLATVLGQMPRDHQQGAGSACRPEDFARLGFSSICHYVQNHSEACDGGGYLHWTEYALCSSSSSSSSSEGGGSLSHVLVLFCSVLFFLLLFIHLSITADSFCKNIAAIVDLHGISQNIAGVTFMAFGNGASDIFSSIASVISAKRPRADLAISELLGGGIFVTTCVIALIAFSRPFHLMRRPILRDIFFYLLALALLVFVSYSSHTMQLWHPCAFLLLYLVYAAFVVLSNLFRQQMRPLERRRRMRKTIGRFSLLVPPRTSKVAPIADEKGPKGMELDERAIAGGEGKQKAGRFIVTPQSMQIEASVGRRDSSPPFPSRMIAVIALPTGVLIVPTQLNQRQNQSQNDAESSAKAFLEAGRFFAKEELDELSGDEGTEEFTPAEGGNTPSSPSCTPSSIDGCRVNESVGNWAEARRLVSEFCSLDGHRLRRSAWPTQLFLIARIPSLLLLRLTIPSATRCWSKPISTIHAFMAPLVFCATFQCLKRPLPGFPSFVVGELALLLSVLLALFVLFCTQMHREPPCYKRCAAYIGFGISIAWIYATASEVMNVVLMFGTISGIPHQILGLTAIAWANSIGDLIADITVARQGMSRMAFSAAIGAPLFNLMVGFGTTFMIAELQGKVVIIEPDPVALVMFVFLTLSLLSTLLLLLFQKFFVRRLHGFVLVALYAAFLVVAIMASQRTLFVSSSSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXK0</accession>
    <name>A0A914GXK0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXK0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11691.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11691.t2"/>
        <property type="gene ID" value="Gr19_v10_g11691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="583"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11691.t2"/>
        </source>
    </evidence>
    <sequence length="661" mass="73855" checksum="E891A8E569600278" modified="2023-02-22" version="1">MAGGNSERGEGRITFSLRPWGRRRVGLLWKCIGRRRREEEEKKKKNGEIRDRAKRRSAAAVDGDVASLSEKNRGERRRRWERRTVCCCCEVEMMGGHRAATNDKSFTSSNRHGQLDSGQSDSEDNPTEVDNRTVDNTTSSLVLRMGKRKLSQTAHNVNPAQKRWKKDFDHKKAKGKKGAAPAVHAKGQQQQKPRQLPTAFQKKKEKEALKFESESDEDEELTGEEMEDESESDEGEVLPQTKAINKKGAAPAVQAKAQQPQKKGQLVTAVQTKKAKETLKFETESDEDEELTDEEMEDESDSDEGEVLPQTKANNKKSAAPAMQAKAQQPQKKGQLVTAVQTKKTKETLKFESESDEDEELTDEEMEDESDSDEGEVLPQTKAKDKKVAPVVAKAQQPQNQLATAVQKKKEKEALKFESESDEDEELTDEEMEDEDESDEGEVLQQTKDKKGAAPVVQAKAQQQQKQRDAAAATNAIVAEEDRRRAERDKVTIFLRCEALQKMTEHEIKSLHPDTLSVRTNNKGYCWLLFASEPTAEKALAALSKKTAISGKELYVDRCGAKAQSKSEKLKKGKALDQPINPTELIISNFPLATTTEQLKVIFPTAKSVRLVTLNAKKNNFRRATRALIDFGNEADAKKAFDKGAQIKVGGAPVDLYFARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXV2</accession>
    <name>A0A914GXV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXV2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12195.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12195.t1"/>
        <property type="gene ID" value="Gr19_v10_g12195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12195.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30599" checksum="97CB7D58F12DF98F" modified="2023-02-22" version="1">MPMAQRLGVHPAKEKGVTKYARGYERPGPDRLTRVLELCYVLDGQRVKGEQSANREMIGVTAVAPTVLKVHNERVKGALQLVNNEYLTMASVCFENAPLHVDFRVIGPPSIVYRDNATLRPDSMGEWKPTLRTNYLLNAKINRWVAYAFDPRDGDSVRRSSRLLEGSACTPHYTLLREENDLSMDTLQAMVHCLCFGHQFVTKPTLLPSSAKRNRNIYAHNSKYGLDDSKSLEKVGKDKNLAWPLRNYEDMTTVLSFVTTQFLKDLRVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY78</accession>
    <name>A0A914GY78_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY78"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1230.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1230.t1"/>
        <property type="gene ID" value="Gr19_v10_g1230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="178"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1230.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27673" checksum="50EB81BB39927FF4" modified="2023-02-22" version="1">MTAKACSDESSSSDEDYYNDFSKYKAKAAMALRKLRKNERTTTEKSSLSSDVEDNTLHNFTSHVDHEICLIPTDTPVLTGVIDLTEVDSGDYASLPVKPPPPSSAIVCRINISSKGQKRVFFCDLAEPLVNVIEEFAERTNIDPKRDTPLALGLSDNCTAIELDAFEDLEQSEEDKGVKLKYQMKGRRPVTVCALPNATFALLKELFCTDHGLEPAKTRFILDSDLIGDNETPISLGLEDGDCIDVFHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ06</accession>
    <name>A0A914GZ06_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZ06"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12493.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12493.t1"/>
        <property type="gene ID" value="Gr19_v10_g12493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12493.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35298" checksum="D1FCAF9E54878642" modified="2023-02-22" version="1">MSSEELTDAEKARIASDFLLQSPPGEFNEVFSDVRTLLQDDALLEKGTCLEAVRHYNKAQFATVKSDPGVEHPTLITEHNELADGRFVDPKSGRVFKYDHLHKEAMDSHPAGPKDMDEKLEPWRKALQKELDEYIYEHFHLTGVATVFTPLHQHKEPKLVVLCIESHQYQPKNYWNGRWRSEWHLPNFDGKTAVQKCTGKLRLQVHYYEDGNVQLISEKEAVVEVKMANDREASAREVLRAICEAESAYQRSIQESQEHMESTFKALRRQLPVTRSKLNWLNFHSFRITQQEMKPPSAGQQQQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZE1</accession>
    <name>A0A914GZE1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZE1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12752.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12752.t1"/>
        <property type="gene ID" value="Gr19_v10_g12752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12752.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21207" checksum="B685DFD8ED010806" modified="2023-02-22" version="1">MSDNPKKVEKRLKEIFVCDDVLFEVFKFCGPFVLELNVALLSDRFDFLVDAHFNSMEWSLGQLLIRRAADGNVAEIAKCISYNIERRLSVPQEPLFDKVIGFEVLKISGPLSSTIILIFANSTDPVNFIIYLCARTSSAGIVPFELKNNLTGERLELRRFNGSDWLLVRCPIERTKQEMGRVAKGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZP7</accession>
    <name>A0A914GZP7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine racemase</fullName>
            <ecNumber evidence="4">4.3.1.17</ecNumber>
            <ecNumber evidence="16">4.3.1.18</ecNumber>
            <ecNumber evidence="17">5.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">D-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">D-serine dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">L-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">L-serine dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-serine = D-serine</text>
            <dbReference type="Rhea" id="RHEA:10980"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="5.1.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="4"/>
    <dbReference type="EC" id="4.3.1.18" evidence="16"/>
    <dbReference type="EC" id="5.1.1.18" evidence="17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11885.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11885.t2"/>
        <property type="gene ID" value="Gr19_v10_g11885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070178">
        <property type="term" value="P:D-serine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006563">
        <property type="term" value="P:L-serine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000041">
        <property type="entry name" value="Threonine ammonia-lyase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="780"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1120"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1236"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1269"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00070760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11885.t2"/>
        </source>
    </evidence>
    <sequence length="1716" mass="188193" checksum="93F7216336833699" modified="2023-02-22" version="1">MNVVDELPSKVCLLLSVSVFLVPMVAGYKHYGTNAGGRTARTPRVGGAHRLFGAFPPRRWPSSSSASFETEVREQFEQMPWPLPYQTAALGWAQWSEWSACTRKCGGEGVQFQLRRCLDMYCSGPSARHRICGKKKCPPNGPTESAVAVECALRSSLHDQLLPVTSTQNCSSLQCVSRRNGTFHNFDISLRDGTKCHLTIGHPNLAVCLDGKCRAVGCDDVVGSSAREDQCGVCDGDGSSCAGELFRWRDTGNFSPCDKSCGPNSIRVSVSVCVNIHTERVVPERMCADRARPRPQIRRCEHIVCPSNSHLTPQLRHQWLAADWSDCSATCGTGEQRREVFCVERVEKDVDRRVDDVQHCWQSQKPVEMRKCNFDACPEWRAGEWGACSASCGRGMRRRSVKCLRADELFHEFHCDGKKPAQEQPCWSGISCLGMDGEEEEEGEEWKRPKQLISYSEGAGDRQMRPSFIASDWRECSASCGPGIRSRLVECVAASGALRLPDYECQDQSKPVQFQPCHLAPCPVKGTPAQSAIRSLSFPFGGSPKNERGENGTSIFRWELGEWTKCSALCAGGRQRSSVVCVDTVRRVTVSWTNCEGLRPQELTRACNRQACTPDWEIGPWSACSHACGGGLRTRRVRCVRTARDSGAAAVTLLVMPDAQCPGPRPGDKEPCGVVDCAPEWLAGHWGQCSASCGTDGEQRRVLRCVRRDALGDVRALDMAQCPEAQRPDGVRLCSLGPCPNGLETFAYREGPPGPPPATANLALSKDEPLAEADDDETSPNERKHRKLTLKVGGFANLYEGTSIKVKCPLRGGGDRRRVVWSKDGQRVANNLRLKVSANGALRIFHAGLSDAGVYACRTADGRAQGNVTLRFKPASEGEKRPPAQSADNRTKQQRKGLELLQRVRDSLHRLGDRAALQRLASVNDPAQIRVDFAVSSWADCHQAQCGHGEGVQVRLLKCQLHVGGPEAAPANVETDICEAFGVPRPAATRPCTDERCPRWVSGAWSDCAKSRCVRHGTALMKRDVRCAFSNGTLVPSNAALCDRRARPKLKRECENANCFAEWRPSVWGRCSKLCGDGGVQMRLLRCVWRGTRKPAGRNCEPAARPAAIRACESQRTLAPCDTADDRSSGRENEQSERVQEKNEGEEAESGESGEAQTFVSNHPPPPLADRSNSYPEGLHMPEQYQQQREMFDSSLETQQTPDRAEHRLGLELKTDAEQKLWEAMTKTSDAVAVPEVPQEEKPLVPEIEWETNNAIPEESSEEESASEAPREEKPVSEAPREEKPVSEALRKEKPSQDSGRRLRDVVVKPFTGWQRWRGAANFAFVRRASPPLRGPKSLLRHFAPFPNLRAGARAGAVLLQLQAFRQPNKKRLNGQSSRPRPNFSSHKIAMSGQLCPNNANSLTHSTILSAVDRVRPHLRASPIFTSSSLNALCGGKELFFKCENLQKTGSFKSRGAMNAVLCALERNANLRGVITHSSGNHGQALAWAASQKGLRCVVVVPKNTPDTKLDAIRSYGAELIQCEPSMESRWSTCEKLARQRALAIVDPHNDYDVMAGQGTVGVELLEQVPDLDAIILSVGGGGLAAGVATVVKALSPRVKVFCVAPEGKCLQAQLEGGHRALSSELLATVADGVRVKQIGQKCFEPLLKFAENCVFSLSDAEILAANRLLWQRLKLVTEPAAAIPLAAMIREHSSEALRECRRVGLIVCGGNVRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZS1</accession>
    <name>A0A914GZS1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZS1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12862.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12862.t1"/>
        <property type="gene ID" value="Gr19_v10_g12862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF35">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12862.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12811" checksum="BB68603D060C5C41" modified="2023-02-22" version="1">MDVIGLSHDWSADLWDWPLQHKDGVVRVHNGPERWEVGLDAAFFRPDEIEISLAGDHLFVYCHHEERSDEHGSVSREIKRSYKLPEDVDTGTIRSHLTLQGILRVTAQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZT4</accession>
    <name>A0A914GZT4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZT4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12874.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12874.t1"/>
        <property type="gene ID" value="Gr19_v10_g12874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502422" evidence="2">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12874.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="21614" checksum="98BFBEAB734B314F" modified="2023-02-22" version="1">MGTLNLRAALFFAFAAFLVVQCSCDSSEQFEEPSDDIKRQLSSPEMLEDGPEMPSDGPSDRRKRRSIGGFFSALFRRNGGGSSSPPPANSTGRSPHGHSSDCSSDKSDESSNGWRLWGPRRGGWGHRRGGNGWGPFPADFPRYNNTGVAPVPFVPTPSNSTYQTIVELLSNGQLGRKKRSPSSESSSDTSGESSNSVPPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0D3</accession>
    <name>A0A914H0D3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0D3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12881.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12881.t1"/>
        <property type="gene ID" value="Gr19_v10_g12881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12881.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10431" checksum="FEEC93657EB860F6" modified="2023-02-22" version="1">MISVKISILSTQYNGYQNQGQSKMAEQMCRIRAERTVGDQIDALLAFLANERGEVYDSPMCLMRDCEGQTLDEGRPIEDGRAYEMDIEVAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2C2</accession>
    <name>A0A914H2C2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2C2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13232.t3">
        <property type="protein sequence ID" value="Gr19_v10_g13232.t3"/>
        <property type="gene ID" value="Gr19_v10_g13232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="119"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="397"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13232.t3"/>
        </source>
    </evidence>
    <sequence length="570" mass="62862" checksum="A009C5224893A5A7" modified="2023-02-22" version="1">MPKSLLLKQKCVSVKRRIPDGWPGLGMMPWLPGGKGCGERMGWANDGCDKAWDANAKEKRSPVPFFQLETINANRDGCANFKKHLKVILRCFLIDSLLEERQKKLAASVAAKREANGFNPEECEREKEVGKESTMPDLHMEDKETINDQKNGTTDSEETANEEVLPTFDEDKETDNRVPTNHSDQRMGQEEVGSDRKQRRALLEALVKLEPVAVRQGEKTERETDGEAESVEEGGETALSSTTVSAEFLHKFRLFQQQLASTASFSGGWPLISTNHSPIPANFVRLPFAPFSLLINNSNNHPPKSFASNSWRPSMPSISMPSVAKRRVKATNGKVGNEAQTMRSNDASQGNFLPAWAAPSFLNVPNVSNGSVTAMLASIGAFRAAAAAAVVSASMHNDGTNLNRNSPIPSRPDERELRGAKLPNNSGRIGRRPSTSAQQRQQQRHLLPHGRIGRSSNAKKYRCDICDKTFSRSNTLITHKRIHTGEKPFRCEHCGRAFRQPGNLTRHAYTHTTVKPFVCAECGKAFNRASNLQSHVRVHAAVSGKSGENSGGATRQFDSDQRLTTTIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H368</accession>
    <name>A0A914H368_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H368"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12836.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12836.t1"/>
        <property type="gene ID" value="Gr19_v10_g12836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12836.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32471" checksum="BCDF8693E0932DB2" modified="2023-02-22" version="1">MKSSPLPFHPSLHFQHAFIKKFIFLEAAQSNKITTRHIHSFPHRITLPKLVIHNIIVNKSPSVSVPSTDRPYSPTPPKCLSVESLQLPSAAKVPMSAASGQTHRRIVIGAGMPTPHRSRPPLRFDRTFLEERDNQLKLIQLLCGLVAFLLTVQCWPNPLFPYCLGRIVNFFQLFNAVCVHGFFLLGTFFLALAHLFSAPDAFYYYNFSLLEQFYCGLASVMYLIGSVFAILNMSRAIFALLWFFHLFVTLACLGLYTFDLWTRWKRDKQFKKDQQHNQSAYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3D3</accession>
    <name>A0A914H3D3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914H3D3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13470.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13470.t1"/>
        <property type="gene ID" value="Gr19_v10_g13470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043540">
        <property type="entry name" value="RING1/RING2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13470.t1"/>
        </source>
    </evidence>
    <sequence length="509" mass="55948" checksum="296C68F5C7847C46" modified="2023-02-22" version="1">MQNAIWQCDPKRTKILTAKILLYQKMNNGLLGPNTTDTVTGGKTLELSKYDKIRKPHKMISDDTKIKVTVRTLSTELCCPICLDLLTCTMTTKECLHRFCSECITTALMRGNKECPTCRKKIVSKRSLRPDPNFDFLISKIWPDRKFYDAELNASMQFFQEQSNVAALQKSIEEGIKAQAAYRKQRVQGSYDYEKRRRRPPKMIVDSNSNVATPPASSSMDNGGGEGQSPPAGAESASGDMVEQVVVPLTLVEAMEVDSPVGGGDRPHNQQIPATNTTFSSSDESDTSSDTSSDDSSDISTDSTVSADLSSDELSNPSTVRSVMDEPHQQPNDQTRSRCSSSEECVDLLTIEAMAEEMCRRGDEIEVELAPSKLLLSSGPVPAQMHCSHFNKQWKRSRRPTTANAAATTIESPPEKLSHFGSPASIAEVVPSGHALEERSGADMADVIGEELTKMVEGQGKMNANKDGEEKEPVGNEREKRTEDAEKKELARRSGGEGSTVQITFQFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3H8</accession>
    <name>A0A914H3H8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="12">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914H3H8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13654.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13654.t1"/>
        <property type="gene ID" value="Gr19_v10_g13654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037976759" description="Sphingomyelin phosphodiesterase" evidence="16">
        <location>
            <begin position="33"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="17">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="172"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="331"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="529"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13654.t1"/>
        </source>
    </evidence>
    <sequence length="610" mass="68612" checksum="DB80BFD00BE64643" modified="2023-02-22" version="1">MAIWPLNGSVLQMGLVLLATTFCVGPFSPCDAFPWKCYGCRGGVELLRLMYERNATADKILGVADFVCRHFADTDSFVCNGITDQFRDEFLYVLGRLALSPGQLCALLVANCGTPADPFNTNWLVPLPPKNTKNVRPLSATNLFPPARPLRILQLSDLHFDSQYTPGAEADCAEPVCCLNRSSAHHPGQSSSTTTRKPAGKWGTLANCDIPLRTVQNMLEHIERTQQQVDFVFLSGDYVHHRDWAYSRAGHLSQLDTLTALLRRHFARVPVFWTLGNHEGVPWMYRAMLRAIERTAAPLPKAAERSAIYRGSYMLPIWPGIRLIALNNGYCDKTNMFIYLNQTDPDGSLTWLVDQLWTVEKANESVYILAHMPPGDRECLESWSRNYYRIVNRFADTIAAQFFGHTHADSFRLFYEDMNNASSRVLSMLYIAPSVTTYVGVNPAYRVYVANPHDGRILDVENYFLNLSAIVDDQQQQPEWQLLYTAKTEYGLDSLSAEAWNALAQRIEREPEMAQKFNRNYARRADAACDARCVAERVCAIRAAHSNATALCQQQQWQRRPLIGGDNGKEGGAKVPSSPPPGLLREVWEWMTNALKGTQNDGGPTIYQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3R7</accession>
    <name>A0A914H3R7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13378.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13378.t1"/>
        <property type="gene ID" value="Gr19_v10_g13378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF37">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036779236" evidence="4">
        <location>
            <begin position="33"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="60"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="470"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="604"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13378.t1"/>
        </source>
    </evidence>
    <sequence length="1299" mass="143578" checksum="E6C6DE8A8F8C2785" modified="2023-02-22" version="1">MRLYSPTLSSPRRAKRSSAVVFFLLVVQNAICSSPPEVGNSLPLSPHECASHTQLPPPEVYRGENVVLDTYLPWMAFVLGLSICTATVVSRYFVLSADLTVFQRLIPFLPQQKRSVTVYAGSANLSNAIPHAVERIILRSEYADRYDDIIGSVTMADMALLKLAVPLNFTETLQPIGLSKESSALAAGEGLATAKQGEVVVAGWGNTKPHCESSPIWKLTHPKIPEQLQFGRERVLPVSECVALEFRWFKDQMAKKNGTTLKDGAWNERELKRRVLAKMADKICVISDKEPHTVGDSGGPLLLSLGQGQWAQLGTLTGGPCHGKEAPLHDRRRSYVPIIVEKEGRTAMPPHQKTDRRSPHGFGSSLNLGATPVADALLPELAPFCYNYAAIYDGPKATSPFLMRPSCALPSNPAGDQLKPSLVSSYGQVDVFFISDSSTEIAGGFEVPFVFTESFNQLEQAEFRAVDAPCGGIKLASADWQTVEYSSEKTLTRTNQRHKRCRWLVYSDEQQPVEAFFEQFSFPSTSGNCVDEFVELRDVGALAECEHPSCAREASQMRGNTVRSCGRYAPGWHISATSVLQISTSVQSQFFANFRLRFRALSACNRTIEIDGNVSIASGRLTSPHFPHSPYAHNDSCATRLLAAPNHRIFAVFKTFELERGRYMAGLLGGRPRWRFDRSWLDRKRRTIVRPPLLIGNSGRQNCVYDSLTIYANISEPRAGLSYCGAWLPPSVMSEQNELFFVLETDASVAGSGYELSYYSVSTYSMFTSLSQVFELAPTRERSGALTSIGYPGTYPASSLMRATIIPPTGLRCVAEVLRADFGGDCRESDGRFPARSAFSPIDSISRDYSMPDLNSLEWDPWPCAVDVPLKLTIPVGSLLLVEFRSDSKPDNDGDGFRMTWNCEDVQQKNDEEEAEYKHPSKFPSFWGIGRTTVTTNSDKLVNTMIEKLMRLYSPTLSSPRRAKRSSAVVFFLLVVQNAICSSPPEVGNSLPLSPHECASHTQLPPPEVYRGENVVLDTYLPWMAFVLGLSICTATVVSRYFVLTVFQRLIPFLPQQKRSVTVYAGSANLSNAIPHAVERIILRSEYADRYDDIIGSVTMADMALLKLAVPLNFTETLQPIGLSKESSALAAGEGLATAKQGEVVVAGWGNTKPHCESSPIWKLTHPKIPEQLQFGRERVLPVSECVALEFRWFKDQMAKKNGTTLKDGAWNERELKRRVLAKMADKICVISDKEPHTVVESGDSGGPLLLSLGQGQWAQLGTLTGGPCHGKEAPLHDYYTQIDCEWIAIQTEDEVMCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H439</accession>
    <name>A0A914H439_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="13">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H439"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13458.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13458.t1"/>
        <property type="gene ID" value="Gr19_v10_g13458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03577">
        <property type="entry name" value="NTR_TIMP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF329">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="NTR" evidence="15">
        <location>
            <begin position="436"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="324"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="13">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="436"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="438"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13458.t1"/>
        </source>
    </evidence>
    <sequence length="585" mass="65866" checksum="289809F48D2849C9" modified="2023-02-22" version="1">MILLTESRRPRHLIGLMPPTDQSFYHAKRRPQFPRIISVRRSDVVKRSFCCRDSLCRLVLLLLLALLLVGKSSLAHEDALLDEMEPVKEEDAGDYLTQFGYTTPSQLNVKTDGMAGDLSNVFETAVKAFQDFAHLPATGVLDIKTRKKMAEPRCGMQDGVEMLTAGGGPAFKWKKNDLTYAIHNFTPDIPKNAVREAIRKAFGIWGTADINIKFANGMHDDPWPFDKKGGVLAHATMPPNGMLHFDEAESWVYMDAEKIRTHKFTDILPVAIHEGGHALGLSHSKADESIMAPFYQEQVDKQGNYIYPELKPDDVRAIQAIYGPRNGGSKAKANNQQQEERKTVHSQNAARGDGLDEEAGEEERPRTGGGRSRTREQDDGGGRVGQTLLNKGKKALKQMFLAVAVKRRKRTKMNCSSFLPFLLFLLIEWPNISRACQCQWAPPKDNYCSADWVAHVQVVKRQDGVRMPAGIIDRQTDLNSRHEIKYLKMFKISKEMPVNQQNQVILPVNVYTATEDAACGILLESGHEYLLAGDYVNGTMVTGLCRQILLENLKESRKHDILEWGEVPQKLKEQLEKQEFDHQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6S2</accession>
    <name>A0A914H6S2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6S2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13751.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13751.t1"/>
        <property type="gene ID" value="Gr19_v10_g13751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13751.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9289" checksum="6239A1836845F1D9" modified="2023-02-22" version="1">MLPQFAVRKRRAYNSAVDNSALDNSAVGQLGTRQLGSEDNSALDNSAIADGIHLSVSTQKGQKSFICLAMSAITVERNLQTTIQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H741</accession>
    <name>A0A914H741_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H741"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14306.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14306.t1"/>
        <property type="gene ID" value="Gr19_v10_g14306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="529"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14306.t1"/>
        </source>
    </evidence>
    <sequence length="698" mass="80742" checksum="AD650DDD9726FDE2" modified="2023-02-22" version="1">MSDNPREAEKKLKEIFICDDVLFEVFTFYGPFVLGLKVALVSDRFDFLVDAHFKLKEWSLGWLEVRRATDGTGAEIVKFIGNKVVERRLQIPQEPLPDKVIGFKNIMISYIDQSVIEFLQSIQRLFGSKGSNLLFMTVVNQNRSWEIIWHRIWPLINENICGIYLASCNLDRLRQFSLAVLRDCPKLRRIYSFNLFPVFPADDSAGASSAQALAKWLHTPRADGLPKMLECYYFDSERMEGLKKAFVNSVFSVNFIINIRNLNYVDLVPFELKNNLTGERLVFRHFKKDKWLFVRCPMERDEDKWAKWEKEAALWSRSWILITVNFNDSEIGDGLLDASEGPSEPKKKRNLDKFSQKQKIAVLFGRRFTTNLLDKAGAVKLELKTFDEIFGEGWWDKGEAEDLKTPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQNPPFTDEFTLLNQSRRLQIKDIASHSTNASEALAQIILWKWEGGAQKIEKNITLNKGKTVEIDCDKASIVIRILKKRGEVIENPSPPLNSPDAELTVHIGDRQVTVSANRLMSVSPVIERMLSVEMKEKQQRTLNLDGHDITMEQFMQFLETVNDHLRHGRTLPNPTNVLCLLGLADYFQIDWLKECCEAHLVNCVEIPLIERFLLIDRYRLNNLKNFFLHCLNADKLKEFLRVNHEQQLLSDASIDKKSWYELIIRFCAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H753</accession>
    <name>A0A914H753_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H753"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14815.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14815.t1"/>
        <property type="gene ID" value="Gr19_v10_g14815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14815.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30795" checksum="53B1A514FF985A54" modified="2023-02-22" version="1">MFRVSICDLMYVLTSYCANRLPSMIGLFFTQHTFQATNLVTAFILLNRLTAIIMPLKHEKLWCKFLPFITMFVFCMPILTSWPIFNMNGIIQFNNPNSTTDRNFIVTEAANGPYLKYYVYVCAVFSAIFTVLCVLINIATFVAYKLHVKNSNNNNGIEIEKKLLVYALATFFGHMLLASYYLSFTIINLDDPKTRAMVYVYYSPIMDTTTVMFSSFFLLWASSPFRQQLLKDFALIRRNNRVAAQEGPPRNNHQFQTSSLQRMPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H758</accession>
    <name>A0A914H758_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H758"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14633.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14633.t1"/>
        <property type="gene ID" value="Gr19_v10_g14633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14633.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11779" checksum="3FCA1FF129A54E40" modified="2023-02-22" version="1">MHKFVCEKCDEDRCNNADDGAADDNTTAAAPLMRINGCQNMKTFIHQYGWNRFYDPYRRYYDPYHDSYIKLYDFRPRLIDGVYLWFGHQKWPRKLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7F3</accession>
    <name>A0A914H7F3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H7F3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1490.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1490.t1"/>
        <property type="gene ID" value="Gr19_v10_g1490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1490.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40514" checksum="2DA64938A90399F5" modified="2023-02-22" version="1">MDFVEWSYSVHTLFIYLTICITIPSMALYIAEVVVIVRHKKFQNSFYALFVMRAIPDCLCVLNSFYGYRLPSIIGSLLYPIYSKFPNWMLAMFFFFGGHTFQTNNLVTVFILLNRLTAIVMPIKHEKMWQKFLPFITIFVYIVPTFTCWSMFKMNAINQLNYPNSTTDRSFIINEAGDAPNIKYSFYISAAFSVIFLVLCVLLNICTFVAYKLHVTKIGLNGGNNEALIERKMMIYAVTTFVGHMFVASLFLILISNFNDPKTTVMFVIYYPLVMDTGTVVLSSWLLLWASGTFRQQLIRDFGIIRKTTNIPNIRVDAIEGLRSNTRWAVGGGAVGHQLQSRIYSSVQQLPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7L2</accession>
    <name>A0A914H7L2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7L2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14562.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14562.t1"/>
        <property type="gene ID" value="Gr19_v10_g14562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14562.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14409" checksum="AA08ABDCAFC1F90E" modified="2023-02-22" version="1">MMSADLLSTDGGRNRLKIEKQRGVDVMVARFIKHHIFDAWSLKKRLQRIKPAILETRKLDYYVLLPRLVNELKEIKKLKLFSEWQQSAAIVRQKTAFLVNCVFPTMTVEYRRESTSSRHCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8U9</accession>
    <name>A0A914H8U9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8U9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15121.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15121.t1"/>
        <property type="gene ID" value="Gr19_v10_g15121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00917">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="77"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15121.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20044" checksum="C3EBA41F3F5A4DCA" modified="2023-02-22" version="1">MVEPRHRSPASVIAGTPQPGDDIDIPDIHILFILQQSNTRTHIENIHNEAVKCECPLNIGGDQANDNKYKCRGQIVFRMPKFKQFSEGRGPKGVLSAPVVYINGLPWRINVRHCDAHVGLYLQCNNAIETDMAGICRAAFQFSIVSCKENAKCQGDLDDFGYVYTANSGWGLQKLSNLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAP9</accession>
    <name>A0A914HAP9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAP9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15342.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15342.t1"/>
        <property type="gene ID" value="Gr19_v10_g15342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15342.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13510" checksum="62AB6CDD695C9955" modified="2023-02-22" version="1">MDWFCGSDRFNMFICYSAQTGQINCDDKFCNCLAEAANGTRVCSAYEAKAFCLLVRQFGDGPYRASAPSILNINCTWSRCGFWFNTAKQLGCDCDGTETRGCGPLGIGRSYQCCPTCLINGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBC8</accession>
    <name>A0A914HBC8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBC8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1554.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1554.t1"/>
        <property type="gene ID" value="Gr19_v10_g1554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037632378" evidence="7">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1554.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="35159" checksum="F5239019EF949F76" modified="2023-02-22" version="1">MRCFDAAISLGLARLCLRLWYSLSLKEAISPESRLSVSFNLIFWWCEEGLLLEPERVLHARVHHFRRQQIFFLKLHIRQMDFEFAAWQMLYLLINPQKVYRNFMYRKKAKDQWARDDPAFLVLLALSLLGSSVLFALSLNLSFSSFCAFFLWAVFIDCIGIGLIVATTLWLISNRYLRRSRDCDVVEWGYCFDVHLNAFFPLLVLLHVVLPLLFYGLIDYQNLFARLFGNSIWCIATVYYNYVTFLGYTALPTLKNTQFFLYPITFLFIFFVATTSAGWNISVTAMDFYHFRASSASRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBM9</accession>
    <name>A0A914HBM9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBM9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15119.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15119.t1"/>
        <property type="gene ID" value="Gr19_v10_g15119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15119.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13917" checksum="05CF7885FDDC72B1" modified="2023-02-22" version="1">MPHRSTTIGRRHVRASASRYFNIFNLFCFQNNVLLLVRLFASRFVLLSSANRRADSPRLHRAFLHQLFALRFGFHSGGDPCDLCLLLRERDPAPLKSKKKRCIGLDPGRGKCPSHPEDSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC86</accession>
    <name>A0A914HC86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large ribosomal subunit protein bL35m</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15767.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15767.t1"/>
        <property type="gene ID" value="Gr19_v10_g15767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019338">
        <property type="entry name" value="Ribosomal_bL35m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15767.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23316" checksum="AB0DFA9B0B3942B9" modified="2023-02-22" version="1">MMQNIIKRINASGPGLLTPLSAAVQTISSRGVLRIPHWENHIRFDPRFGRKRPAQDVLERFKRLNNGMWLRSLPGRFIKVYQKGDSFRKVHLQWETCTASECAMLDKMMTPFWLRPKHYVDDPLEPYHTRYGLTSPRVNDQKQFVRERSTILLDDLTSTRFFDRIPADQTKSGLLLQEQNSSLPKLLRKTMPKKILPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDZ9</accession>
    <name>A0A914HDZ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDZ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15746.t3">
        <property type="protein sequence ID" value="Gr19_v10_g15746.t3"/>
        <property type="gene ID" value="Gr19_v10_g15746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056314">
        <property type="entry name" value="AP3B1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029390">
        <property type="entry name" value="AP3B_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14796">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24080">
        <property type="entry name" value="AP3B1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01355">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP-3 complex subunit beta C-terminal" evidence="2">
        <location>
            <begin position="57"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15746.t3"/>
        </source>
    </evidence>
    <sequence length="340" mass="37874" checksum="3B2B60841331F5F3" modified="2023-02-22" version="1">MQHEDESDDGQGVEEEPIPSNSKPREEEETIAEEQTAEAQPLVVKTTTKKDGQQKAVHSEDLLLLDIDFGPPSTHINFVVSKWRRATAQYVPDRFELQLVESLSSGGLCIAGRFCRSPCLYSTSMVTVQLQLSYQSRHIRCCDVRLSPATNCFLPTSGPILVEALKEGERRTLTLGIDFGDSTQTSEWTVKWGEGGEKTTKFDVQAPYEEQVEGIECDAEQFVECRAKLTGMNQIRCALSRKTDQFIGRALLKVCNCKQVLGLKLCFAAQTVSRKELVLISLVGRGKEDRFDDDTDDCSVQVNCDNITFASDVTVRLPASTSDIPSEFFCVLFFDETSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEG9</accession>
    <name>A0A914HEG9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEG9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16260.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16260.t1"/>
        <property type="gene ID" value="Gr19_v10_g16260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001666">
        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001729">
        <property type="entry name" value="Zinc finger protein 337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16260.t1"/>
        </source>
    </evidence>
    <sequence length="897" mass="97713" checksum="F7E74FEFC06C1005" modified="2023-02-22" version="1">MPVYAEQSYNSKLALRFGFATAVHKVTLDEEVLYSAIQKILSNYSNFKDNAKRAHAFFLDRALDGMQMAEYGVRRALREGGRGRRFFCSLEFGANAILKGLVKCLAPPLSNSSALPHSVSMETRPMPPPPPICPASLHRTDVVETCVPFAAFPSAGCQPQLCDHQQRIMGQQQQKVNVPPSKVTEFRLEMQSAPRLSQQNPPVSVSSSTCAALDYFSLFLPQHEDIFHSFGDAPPPPPSLLSGEGVANSQTVQNREGEGSYLCEDPTSSSASSVSSVPTIYSTAYSSSSAKTSATASTSSSVAAKSQDRKRPYPCSTCDSRFGSKMELEEHQNSHTGMKPFQCDVCQSRFNRRSTLWNHKRIHSDAKPFKCTVCQMQFKWKNSLKCHKEMHLRKNELTQGAMPDADSQLLTYATAAKKTIESLSALETLGASSSGAVLPPPSAMALLPHSAAPSRLLTCAGTPRKRAPPKNGGVNGKGLKIGKGNAPVERRKGGKGGGDGTTTAMVAVSGAQPFSVNLFPFGVGDTSTVVPEMVQLKKEPKNVQHAEELAALRREQALQQRHQQQFNLFPLQCGVETVTTGNASHNQQHNAPGTGPIPQQQPQHFFAPNQQIPLVMDQQHQHIHHHQMNSNNDHQLQNKQQYQQQQQLDLQLSQLVDPSMLLQDFQLAQSGTGGINGQVGMMPFLGFDLQQQLNSLTTAQLSGSEQLNNSADCNSSTLPSTVSTSVSVIFSSPSVPCTSSPSFFVPSSSSNHCFANPCQPSTSTEVLLNGYHHQFGTNSMRLLSSAAKVPQQKQPINEVECQHDRQPFGFDGFCTTANGGAELEEFGIRNNGPQLQMFGQQQQHFTQTGQFGQLHEGTDQHHQSGGAATAERVDGGHVLLAHQIRFQGVAFFRRSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEK5</accession>
    <name>A0A914HEK5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEK5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16634.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16634.t1"/>
        <property type="gene ID" value="Gr19_v10_g16634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16634.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8855" checksum="A866A82312E64500" modified="2023-02-22" version="1">MSDLLVRNFDFTTKIVSDTDCSTNKFVPLIQLRLYCEDRQKCARVLIYEFTLAEAREFVLSLDDNNDAEEYSRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEY4</accession>
    <name>A0A914HEY4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-alpha-glucanotransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g16370.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16370.t1"/>
        <property type="gene ID" value="Gr19_v10_g16370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000070">
        <property type="entry name" value="GDB1p Glycogen debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="2">
        <location>
            <begin position="111"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="3">
        <location>
            <begin position="652"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="1">
        <location>
            <begin position="942"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16370.t1"/>
        </source>
    </evidence>
    <sequence length="1417" mass="158637" checksum="115AFB88E182FE21" modified="2023-02-22" version="1">MSTLCIELNNGEFLDSKVVRVEKGWNLRFTLGSGLSGKAVRVRICESEVEYFFTEMATIGDLDSRISWDYHCDQFGAFCYEFFDVDGNALSPVGRGFFCVVPEWRIAGGEKRLTLNGLSVVTHLAKLLGPLGEWEDRLMVAREAGYNVIHLTPVHRLGISNSSYSISEYDQLNPSFEANFAALKHFVDKMEREWHMLTIQDVVWNHAAKNAKWLQDHPECAFNCANSTHLRPAYVLDRALQQFSREIGEGKWAHEGIPTVIQHDSHLSALRHVLSSKVFPSIRLHEFFQADVESLGNEFRSYISANIPSNKNAMSDVESIGLISDPNFCRFGCTVNLSLAAVAFLREPGGIDSAAVLGADESICRFVAHLNRINGDARRTVDGHIATAIDAIIGHVHYERVAENGPRKGAVTLNQPLVTNYFLHPPEFGLNDWKEDEKLAFSSRTAVRLMACNGWVMNADPLANFAEWPCQVYLRREGLSLSVGLHAPLLGGITPIHVAEYLLKAARHVRRDLYVVAELFTGSEKLDNLFVNRLGITSLIREAQNANDSHEQGRFVYRYGGDPVGAFHCKSTRPAPWAVAHALLYDQTHDNPSPAQKRTPYDFVPTAAMCSISGSACGTVRGYDEFVAHNIDVVNEDRMYRKWSEFTEDAKGMIRARRLLNDLHVQLSTSGYSEIFVDQVNEDVVAVTRHNPNNHESVLLIAHTCFSSFKWTPNCRAVQVADDITGILFELKTVEHPQKDVSKVFQNDDGIISGLHNFYVECFEKIDLDNSEAIEVVDGAIKFKLFLSGSAIALKIKPTRKTKIACEQIDAIISNETARTEARKLLEQLSFLDFNYLLFRCEPEERAEFDGNAAYEVPNLGKLVFCGLMGIRTVLQRIQRENDLGHPFCENIRRGNWLFDYSVARLNRRESLRPFASLLAEAFCPLVDVPHFLRPSLVEGNGGEMASLSAGLPHFAEGIWRNWGRDTFIALPGLLLLTGRHAEARTIILAFAATLRHGLIPNLLAEGKAPRYNCRDAVWFWLVAIIRYTEKVENGEAILGESVLRLYPTDETEYGEETKMEPLSVTMFEALSRHFQGIAFRERNAGPRIDEHMRDEGFNVRAFIDEQSGLVFGGNRWNCGTWMDKMGSSERAGNRGEPASPRDGAAVELQGLALRVARGLDRLCRNGAFPYNGMKGKSSFLSWAEWATKIQRSFEEHFFVDDKCHSEFVNRRFIVKDSFGASLGYADFQLRPNFCIALDASPDILPPEKAWSALEIAGKVLAENAPYGICTLDPKDWAYCGYYNNDDDGTNKISAKGWNYHQGPEWLWVAGCYMSAKLKVASLMYQNSGDATEWMSAVNEVRTRLFALEHCLQKSEWASLPELTNRGGAFCTHSCPAQAWSVGCVLETLDTFDGTMAIINAEGTNGGVGDADEAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFS4</accession>
    <name>A0A914HFS4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TBC1 domain family member 9</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFS4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16561.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16561.t2"/>
        <property type="gene ID" value="Gr19_v10_g16561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF6">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="205"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16561.t2"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113268" checksum="FAB3381D1685D660" modified="2023-02-22" version="1">MKTKRKIRSLVFAGCRFSLPHDERLDGDVTCRLYTPYDKRCVLGQLHLSANFVCFASRTERLVSVVILLRDIVMVEGHKNFEEGITNAIRIQLNKEQENREFIFSAIADQTKVLQRITLFWQNCLRVEKQIKSSLVQHSHSGGGRRLARKILHEPLHAHYPHPQASASACTHLRTARRWEKMFRDYGRGYSMYRTIELHRLLLEGIPFEQKAHVWGICSGALVEMRLNEGEYTALLRRSRHNTTFSELTMDEIERDLHRSLPEHPAFQSAAGIDALRRILTAYAVRNPTIGYCQAMNIISSVLLLYAPEELAFWLLVAVCERLLPDYYNTKVVGALVDQGVFSDLVGQTLPQLHSKLIQLGLDDMVALSWFLTIFTSTIKFEAAIRVIDLFFHEGSKLIFQLALEMLRENEELIVKARDEGEALVALNEFTDKITDSNVKNSTQIFVGDLISNSYKHFADTFTNDTIERLRLKHRLKVVQNLEDSQMKSIVKSVGRECRLRSDELCCLYNVVRQEHLLTWRSRLNTTTAQHKKTSTEERKMGGRAGVERPRIDSCLQSQYRLDFELFAQILSRFLPWQPADEIFYVRAFRLLDMNETGILTFRDLSCFLGTLLRGDPTEKLTLLYRCHIPPAFNMSDLDELIKESLSFGGAELGVEAADVFGSKGASPERSKFSPRPPLDNDELELPQGSSTSTVSLSSSTLLMQSIGKFDGASSINSSNVAFTRSPSAGALDPIETGSLKSSTTEAQSEFSDFSILNNNTNSDNNKHLQARFAQRQRLLDSEPEGRLPSVLSSTSPVASIFGTMPGAQTLEQITQVQFIQFWKTFYDMAGSISGTLSSSLETMESNSANGTNEDECETAMPAEEEDAQLFHALSYVGTLLLQLGEAHRSRREEVERQIVEALGEEAKALIVLSQDDAYIGNNNGEEQPRPTSSISTSSKAGDLNSCINDAEWRLSLGQIVATVLANATLAQIFERSYPLKQRQRRSATDATTAQEGKYISSSLPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFV0</accession>
    <name>A0A914HFV0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1699.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1699.t1"/>
        <property type="gene ID" value="Gr19_v10_g1699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1699.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17867" checksum="F59187A123CD16F0" modified="2023-02-22" version="1">MPFTVTESKSKHIHSFIHSLIASSSSSFLSVSSFPSPFCIHSVTRPHFEKLLANANDGGWGGDGKALGHNLCDSFGWPSSNVLDCLACLLLNSSQPIEKRCIPFRKWGTSFVVGGFCTVSHPLRTARHAEEIALISRSPGADGFINDHFPSPFSLTSSKMMRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGI8</accession>
    <name>A0A914HGI8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16968.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16968.t2"/>
        <property type="gene ID" value="Gr19_v10_g16968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16968.t2"/>
        </source>
    </evidence>
    <sequence length="107" mass="11990" checksum="FD4931532B6839B3" modified="2023-02-22" version="1">MINKSHTPTPYFSCVNNDAWNKAFSFLGPFALGHIIALISGDFDHWVDTHLITKKWSLDSLKICRAKGRNAAEIDKLFVPNGTEVERHLPIPLRPPPANVIGLNICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH84</accession>
    <name>A0A914HH84_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HH84"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17483.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17483.t1"/>
        <property type="gene ID" value="Gr19_v10_g17483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043988">
        <property type="entry name" value="CCZ1/INTU_longin_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19032">
        <property type="entry name" value="Intu_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="13"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU second Longin" evidence="3">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17483.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29398" checksum="FC66E278D2EC6D67" modified="2023-02-22" version="1">MWCSCHDLLHDQQFFFIFKWQKEGSEHKRIMFFHPTEETISKQIEVTGMSEAIVNFTNGINSMDCGKDDATSCDFDFRYITSTNSKEIVLVVEKGNFLIGTSFNKKLCTARDYFPHLPTICSLLTNAYNAYKLLYGLLSSRFHTNSSEFKGTLDRFFTPFLHLYRVNKIPLIDLFNGVDFLSVDNLNFLEIDCLIANCIQEFPCIKKGMFFYQERLVQYSVSKKDLAALCQFVVQTLIPSAVQNEVCPPPSAANRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHG4</accession>
    <name>A0A914HHG4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHG4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17204.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17204.t1"/>
        <property type="gene ID" value="Gr19_v10_g17204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002619">
        <property type="entry name" value="CX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520:SF11">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01705">
        <property type="entry name" value="CX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037195089" evidence="3">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="CX" evidence="4">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17204.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="30800" checksum="F932FC2BF2AE430C" modified="2023-02-22" version="1">MRADNFKVILLFLLLCSAGIVGKRGGGRGGGFGRGGFGSRGASAARAGSASRGGGGGQFGVGSRRRTGGGFGTSSKHGTGTFGGGGYRTSSFSRGSGIGSNSRASTFKNMVIGAAAGVIAYEAGKAIIRSVAAPMRWGGRDYYWGSQYYPGGTASGRTMCRMPVDSSDPQFGNVYLPGGQTRPKDIVWSCNYNEQCCGYECCPGGGGGGGYGGGYWNSRPGIGAGTIFLLLLLGLCAVCILKRLYDKKRENDVEAEERAKYQQGNGSPIPVSYSTSAPPNEGGPPPPYPVNNGFLYTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI69</accession>
    <name>A0A914HI69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17596.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17596.t1"/>
        <property type="gene ID" value="Gr19_v10_g17596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17596.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10431" checksum="C83B488885E8105C" modified="2023-02-22" version="1">MSGRSEIRTRTSSSSTMNQSVLRDEGTVVRQQWAIEEDESTIDRSRSPSPFRPEENNQPESSSIYTELLYVSFGVIAIGTVLYFGYRRFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIL0</accession>
    <name>A0A914HIL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rab3 GTPase-activating protein non-catalytic subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP regulatory subunit family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g17241.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17241.t1"/>
        <property type="gene ID" value="Gr19_v10_g17241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21085">
        <property type="entry name" value="WH_NTD_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026059">
        <property type="entry name" value="Rab3GAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029257">
        <property type="entry name" value="RAB3GAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472:SF0">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472">
        <property type="entry name" value="RAB3-GAP REGULATORY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14656">
        <property type="entry name" value="RAB3GAP2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="6">
        <location>
            <begin position="102"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP regulatory subunit C-terminal" evidence="7">
        <location>
            <begin position="954"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP regulatory subunit C-terminal" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1536"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1802"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1541"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1812"/>
            <end position="1846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17241.t1"/>
        </source>
    </evidence>
    <sequence length="1887" mass="212926" checksum="CFD451C49C3FB3B6" modified="2023-02-22" version="1">MIPMIHNKLTGRARISTDTIILIEKFLNKERTSQRVSPKSDFEGKKFNETLLYPPERPDEFDFETDDDEEIEAEASINTEKINLSSLVADVDGLDNDLVRRWLRKSLISLSVNMEVLVISTAQKFVVLERSKRSADDLNLMEVVAKVEVAQDDRTFILSLAVFGVQPSASNSSSQSLTTDWTCICIGLSTGDLMFYTERGTLIFSEKCANCPILSLRLGHSVLPGNQELVALTSAAKLIVIEGLSLYTTLRSARAQIARADRSINEICESLQLNAHQLQLDRYEHVGDFQTVGLTRPGTFDQYMSAFYSAGRNETVSRTQLPIYAHYMCTPATKKRKDGDDNSEFVSFLWHDTQPVVGTLSDAIFSLTSHITNNIPSFGFRSFTGLGISRKDRIAKKSALDARTKWVPIKSILRDSKRVAERSFIAPSPGWPFVAISDNLGRVLLINTRTRRIIRIWKGYRQARCAWIEAASTSRTSPQKRALFLVIFAPKRGLLEVWSMLNGPRVSAFQVEEGGRLLSIPTIQNGILLGGADIRESESQKTSRAGSVFLTPNGFLYSIDVPFHHSALSASATSVYDEYLIKEFTLDHFTVQPENTEEAGIDLEKLVEFVHRIKTNLAKQRFLEALIVSSEGAFKRESVKRPKGGTLISVRTLRDLVSQMVGNAQNPTDKNISPSESERHSPISPYLLALHSAIDFYATLDDKLAESLYNKNSHNVEFGEWTKHLSLPRCDRNAPLMTKALSIIELVYQNSESLANTSTVVDRIVRCRLDLHDFLNFFNLNLYQNFDSGVQMESTLSPADDKNMPSVSTTLLAKLGATIFAPFLLNCSLDLESFLRSLTSKFRLSKNFLITILCAFWLDPQYIDNGHWAGPFNETLKTIEQMVIATTNVPAALMVAIQMGDVCQQLSISLDERKTDRENVQKLPRDDDDDLFIVFDKYELELQSGLRDELPHFWALASLHLSVFHLLQWLFQQTVDVSNTSLLSPSNFCIAKLIQKGVGFYREQLGLWVSQMDRPPSFSARDIVSVLVSDGQDENKDYQNCFDAKISFTLRLLCKETLPQSLRMELILCDCVWECASAWFKDESRRITKLKRSIDLLDFLHTAPKLQNGLAQLLWETFVASSFEKCFLLIEEQMGSAGPGRSDGGTSPLKGKDRLLRRDVLVVEKDLPEYVSCIRKLLEILAESCCHLCSRQDIAYGPLAGTLHLEDSEITNFVGHHRLKQHLSLTDRKLAGIIGEKTLTQLVDYQKPVNYHLALHMVHLAAVIEIQINLTTSAYSKPSSLFDTNGKRALFNPFHTHPLLPMGRVDDRTKMRRQRFVEQCMEALEKESETQQDNERCRELRRVVDRLTREWTLDVTTLQVNEITRLYLSGADEEAEAKCDGLFGNRQKLALELVPIIAGRINQASTASPSTMAFIKDAPDEYMPNFDQIESKRAGEMQITLWNSRNVSSFCANSMKYAALSTDLLKDRVAAHQQRACDDGAGNYWLTILKDNMEDASRSSSTKNGDGTPPFVLDEAEVGIAITIPSESVDMSLTVEHPSETNDSQQPETDSLLSISQSESDTASKTKSKTPSRAFLAPEVTHIPIQSSDVVEYEWPQKTGVRFFLQEQISELLGINSFKRKYPEMARRTVEPVERDYLLGELKVNIALPSHHLTALQSADVHELMSSEYPNKYVEYQKVCNERLKRLLLEKQKEMEMIKLDAKKMAELRQKAVKSASEFNSELQFVRKTERQQFWEMNTNVIHSPLNKWMRLSAEHSKPSKYPVFLMPGQYTTHYRKFDPAQLRSFPFGSVVKSDELFLPKRGPSPPAISVSEKELEAAKNSNERKEVLDSEKNASPKSPQKEREIGPPPAKLPRMSVSDGGKLSCFNFLGKFFTQNANPQNKRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJV4</accession>
    <name>A0A914HJV4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJV4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1989.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1989.t1"/>
        <property type="gene ID" value="Gr19_v10_g1989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1989.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20833" checksum="D35563EA9C192B10" modified="2023-02-22" version="1">MARSVDKWMCCCGCHVTEGAYKMSWIFTVLNILGGLIAGHLFISTGLTAKTIFYSVNVLVSMLCWLPILCGHIFGKRSHRMYLPFLSLFALSTVYTFCEILFLVLQRILMFKAPDSIYVMFGVSPKEYEQLVSSPTGEFAFYILLMIAFLAFWCWVYSIVFRAYKFTKQIGGDGTSNEPKMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLP6</accession>
    <name>A0A914HLP6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLP6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17792.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17792.t2"/>
        <property type="gene ID" value="Gr19_v10_g17792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31524">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31524:SF2">
        <property type="entry name" value="PROTEIN CBG10426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17792.t2"/>
        </source>
    </evidence>
    <sequence length="958" mass="107653" checksum="51CC208E124B74A6" modified="2023-02-22" version="1">MTSTSDPGGSGSQIPLARGPEAVNPKEEDGELTIVAIDRKFWHGKTSVKVADLERVQADLGRMEDKVNRAFRLMNRSVNLKASWVNDVVANSNLNFETVKVQIATLTERVEDLENERNASTREPSLAGSRRRESNADFVTPQAPRQDEQQEDEGEDERDNRPVWGLNMLSGGTVGSNLEMFGEESAFAFDEWAERFKDYLSISGKTYTEPEKVTRLKLALKDTPRALFKELLPVQTATLESALAALRAKLDSPQRREVAKRTLTLSRQREDESVAQFLRRLTPLVEATNPSLNEAQRKEKVCEEFLDRLKPNMSFLIRLVGLTQAKDLEIVKAQAEELEALLLMNRGDEANRLSQAVNVLNNRPAQTQWNAGPTAGTGANVQGPSGSNVRSFRPFLPPNAQRQQQSFGGGRGGFRNWGRGRQEQFSQRNWSSNPRCHYCQRVGHFAYACRDRRNNFQGNRGRPFRQVSWADQQPRQPQGGWQNRPNSVNSVEMPALPQNSLGFMENLVQSLVEMNVRNNPSRAPGDEEGQASGSMNTIAQIEQKEEVPVEEKVESRVAEKEEETIPACGPEAAKKYQPKTSNWEGTSLKAKVASFSFSAMMIFAFCSAVTGFEKPELPSHPLICQTQRGGKVWQLPEVVGCSGHSVNHSKSPVPRALHIFTQNAFEHSVDAWTCRKVRKEVRKYTSISNVPMQEVVEPQMQEVSLSECRQMIEDGKCSLGVLINESGLMHTDKRIDLSPRMWLLGSFSWTTAASENCYLFKSKVTVAHGGSGRIQSSLGLTGSCQFGDGQCRLEDKTRIIWDTNGTANCEFSKIGTWKGLQLDNVWVSDEVSFRLTFRNESRKVYSCGQGLQKSEEGFAVQDVAMKKGRRTRRSTESLVTESELNAELGYLDEKVRELLTVSFSQMVKSICDYMVETRRWAATALLSDPTAFARKLFQSERIRIRTSRKGCRREARMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNC6</accession>
    <name>A0A914HNC6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNC6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2893.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2893.t1"/>
        <property type="gene ID" value="Gr19_v10_g2893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2893.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16565" checksum="74281AB3F878C9AC" modified="2023-02-22" version="1">MEFLEDDGRPPILDGPFAPARDESMAETNYSDASKDFRLADCLPILESVARAYDCIYPLPKLGRDHHMSGCLLIRSLSSANRLYIFEWEECLELKGHLEMEDGSSKRVLHEFYEKYDGIEGLGRFLRECLFNFFYLMYSAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNP0</accession>
    <name>A0A914HNP0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNP0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2977.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2977.t1"/>
        <property type="gene ID" value="Gr19_v10_g2977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2977.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18704" checksum="36D3AE9DE89FE41B" modified="2023-02-22" version="1">MKAAKTRNCCWESSETVGLFHKKATTSVQRKGLTPQQNRWNSTACHPSLALAELDQLIVRHNGKNYDWISVRAEKRMLENPYFEVKILEQTGTSGGVVIGLATKGMPLYKLVGLHEGTYGYDSFGKFWDTANLFVESAADLFPCVSLTRRGTKIEANFGPDIQFNIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNY6</accession>
    <name>A0A914HNY6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZIP11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 39 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Zrt- and Irt-like protein 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HNY6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2554.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2554.t1"/>
        <property type="gene ID" value="Gr19_v10_g2554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF211">
        <property type="entry name" value="ZINC TRANSPORTER ZIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2554.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="27856" checksum="DBED4AE471DAC1C1" modified="2023-02-22" version="1">MIQNWHPVYQALIASLFTWGLTALGAALVQQATECSLVDASLGFAGGVMTAASFWSLLTPAIEISQSQMSKLAFIPVTVGFALGAFFVSCMIPRCVNAELKSVLPEKAKAQMRKMQTKCKLASKKQSWNAHSETRRNGPPNSAQILPAPKGFRGEEFSFLIVAVTMQNFPEGLAVGVGFGGVGKTPSATFEKAFNLAFGIGLENFPEGLAVSLPLAAFGYSKWKAFFYGQLSGIVEPIAALIGASLALIVFHMPFHPPPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPL8</accession>
    <name>A0A914HPL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2536.t3">
        <property type="protein sequence ID" value="Gr19_v10_g2536.t3"/>
        <property type="gene ID" value="Gr19_v10_g2536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2536.t3"/>
        </source>
    </evidence>
    <sequence length="267" mass="31868" checksum="5AFB083DED6DB5B6" modified="2023-02-22" version="1">MGRNRIWYEQWDKRRTANIDKFHGFRVSPFNDSIILFDDFKLLLALFHDPPTFYEIFKMAKKLGEMDNDFYILLNSSDLKQISKHLLETAKAENNPNIELIGVANDNLILLEMAKAEMRCRKKKKEIKKYIDNKDLYNGKTPKVDFNPINDLKQIVPEIIREIEQMLQKSDWNYANLKYLKMDELILLKYDLHKMGNDQKWEEIEQLRGEWEKAFNDWYFKQNEENRPNFEEMMRNLIKMLSNIDFSGEGNVSDSVVLRALKRAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQP3</accession>
    <name>A0A914HQP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g3565.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3565.t2"/>
        <property type="gene ID" value="Gr19_v10_g3565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="771"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="988"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="868"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1334"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1440"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1544"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="870"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="919"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1370"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1567"/>
            <end position="1576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3565.t2"/>
        </source>
    </evidence>
    <sequence length="1638" mass="178289" checksum="2FF163C05827F6D9" modified="2023-02-22" version="1">MRPLRAQLDIGNHLLLNCSIIHSTSSQLQTKMPSFMCMPFLACNRQVDSLDRRQCNLQSIPGDIERYARSLEELLLDMNHIHDLPKSLFRLQKLQRLGLSDNDIHRLPSEVAALQNLMELNLSRNDISDLPEDLKICHNLQVLDISSNPIARLPDSITLCTSLTQLALNDISLTKLPHDLGRLAALKTLEARENHLRALPPSVAELSQLQRLDLGQNELDELPAEVGALRALVELYVDENSLERLPDAMLRCTRLEQLDASSNKLFQLPDELGELVALVDITVSHNCLRELPSSLGRLKQLMILKADDNTIDILTPAIGGCTGLTELYLQQNLIAELPSSIGNLKALQTLNLDRCQLRRLPALLGECASLTVLSVRDNQLHELPMEVGKLARLRVMDVCNNRLAHLPYTINVLQDLQALWLSENQSQALLRLQQDIDPRSGIKVLTCYLLPQRDASVAAASNDGVPSGTNLVANQQSKAAFVGGPKVHFGGDGEEGANDGTTAAEDGAEMGATFERKNTPHPKNTTSGQGTKLKQYQQQQHKHKGDKVDGHVAPRVEEHPPSIVLSGKKVSHDHSSSLLAPAEQQPSTSGSTADQLRSALKYSSRAIQQQQQQHQTEAAHPPPTAQQRYPPSGSTSQPKTVLFTGAKPAPQTNQAECKLKRVNTPHYKSTRGTTGDGSSGSGSTRTSAPAVTAAQNQFQPAGGISSRRQLPQASSSLPAAAATVAQDGMHVQMEHHQRMQQHHNPSNNNNTDAVKVQLLAATALNAVERMRVNVRRAGADGDGGGGGGLGLSIAGGIESTPFVEDDPGLFISKLAPGGAAERAGICVGDKVLDINGTPMVGQRHHVAVQCIQQSSDVVELLLERRRTTTEHPPFSSSSSAFTAPAPPLAVSSASSSSLHQTVRFSPPAPQHHRPQLGLSSSASANIASHHASASSTTTSPSMTTTTIHHPNTLFPSALTTPAVLQQQQLPSVSEHPFGDPQLDDIVEEVELVRDSRNSLGLSIVGGIDHCSHPFGTPALPGVFISRIAPNSSAHVTRRLRVGDRILKVCSRDISGARHNDAVEALKNTGRTLSITVRHERQPTGLRVVVVPRRDTQPLGLSICGGIGSAPMNPQDRTDEGIFIERVEHDGPAEQCVGNGKPLTVGTRILEVNDESLLGCAKEEAAHIFRTTQPGPRPHRPYRLGRPPQCCCHPETFVQSRNSSCLLRQMPMLTQHIHLLQITTVTKPATTHSSAIDNEKMEQQQHQKKNNKKEQIGNEYQNLSAGHNGRYAVGLIPKNDAKTLVGREMSASVALLDIGTMEEQQQKKMEVTTFSSEPYHNNQQLNKNNNSICEQQQKKVAAPPPPVAPKPKTNFKSFAVTGGSKQQQHNVHGEGTDEKSNGTAPEASADFSSRLRLFQHEPSQNQTSSATLLPWAAPSMKLKRPLLSSDDLAKLAEDDRMRTKAALQPPVENGRRAGSDDTGEEPSQQIGMMLSPMSPFVDGGAFEHILNDSPVPFVPSSIGSIRTKKAENRFLQTNAALVLSSSPSPTISQVVLEQQRRQEWRQARMASLEADNRQQDPPPPPPVGSNSSKSPALNDNHRTRTNSMERTTRPDANFSILFRKAFLYTSLSSILLHFQYLLNTRFCAKFSPFYINQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRD7</accession>
    <name>A0A914HRD7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3759.t3">
        <property type="protein sequence ID" value="Gr19_v10_g3759.t3"/>
        <property type="gene ID" value="Gr19_v10_g3759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3759.t3"/>
        </source>
    </evidence>
    <sequence length="204" mass="22748" checksum="E269F34F63AD9330" modified="2023-02-22" version="1">MARGWPWQRIAFLQSLGSNSVEEFGPRRAGLGRRLGAKRCHAARIWPTDELDNVRVKLLETVHRRVRALIPRARKTHMVHGPRPDAECERPVLRVVRQLVVDHLPIRCAMFAELFLTVGRRAFESCNWQRTGMNNNSAQSEAAPPTVPPFVASCMCLSSPLSHNSTRSSAGGRADATVGDQMARDGCECALPLILRTSCDECYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS90</accession>
    <name>A0A914HS90_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS90"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4186.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4186.t1"/>
        <property type="gene ID" value="Gr19_v10_g4186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4186.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9407" checksum="56E2103A9B7554B3" modified="2023-02-22" version="1">MKNIREERKCMRSNHASVVTHQSTRQKRAPLTSRISNAILLLKSVTEPVPSPLSVTTAEEGMKTMEPLTDGAEEEGPKSTAAADRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSP7</accession>
    <name>A0A914HSP7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3609.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3609.t1"/>
        <property type="gene ID" value="Gr19_v10_g3609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00698">
        <property type="entry name" value="TMPROTEINSRG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3609.t1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43849" checksum="2123EDC20143D4EE" modified="2023-02-22" version="1">MIWLSDHQENAIRGQNFIGRSFVTFSFIKIMGFAEWSNSVQISIFYLSICLNIPTMALYIAEIVTIVRHKKFHNSFYAIFVTRAILDLLYVLDSFYGQRLPSIIGAVLYPIYSMFPNWMLAMFFFLGGHTFLANNLVTIFILLNRLTAIIMPMKHEKIWQKFLPFIIIFVYCVPIFSYWPVFKMEGILKLNDPNSTTDRSFALAEAGDAPYCMYITYICAVFSAIFMVLCVLLNICTFVAYKLRMKKVSKNGNNKFDDIEKKLLSYALATFLGHAIVASMFLISILTNMADPKIQAIVFIYYPMVMDTGTVVLSSWFLLWASGTFRQQLIKDFGIIRKTNIQNIRVDAMEGPQNINLQPVGRAVGHQLQNRICSSVQQLPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSS0</accession>
    <name>A0A914HSS0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3428.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3428.t1"/>
        <property type="gene ID" value="Gr19_v10_g3428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3428.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13802" checksum="DC52568785E59A80" modified="2023-02-22" version="1">MGLTVYCPRHLKTPRLVPWDQPGRCSRCRSGTVELDYFIQAEGVTVFSTRLKNGGENFVPFDEIVDFGDNAKFRIRSRNKVFTLPLRHPEVWQAEPVAGADQALAAQPPAEEMKNGEETKGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSV3</accession>
    <name>A0A914HSV3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g39.t1">
        <property type="protein sequence ID" value="Gr19_v10_g39.t1"/>
        <property type="gene ID" value="Gr19_v10_g39"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF417">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037984913" evidence="3">
        <location>
            <begin position="24"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="871"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g39.t1"/>
        </source>
    </evidence>
    <sequence length="912" mass="103340" checksum="54BEDB447A5A78E7" modified="2023-02-22" version="1">MLLNLKCIVLPLLALFTVHTVLSAWTAENRATKDGTSSGTASTIGTFEHQQHHRRWRRGSAPGLGSLGRGAFGSKSGQRVAHDILPTDGTGTDKKPNWLRNFKRVFKPASRYTHDEVIETIQNHQLHLSFGAVLAQNVEELHKQKELLKAALFYEQTLNLFSNEVIKQENILHEARDHLKFSKQRSVKGGVLKSQNVDPEKHVEELKERVDKLRNTKREIKDIIYKFGDLMNDDKFNFGKKIKAWEIRDNAMLNTVLKEWERKKPDEWDKNDLKIWMQNNTKSEQNAHPLRQHAIKIDTMAKNLVDRILLVDAAFDREARNLCLNAAFAVPMRNWASIAQKMTDEQIQKYVTNVLGNNFLGLQITFDPNIGSTFIESEDDFKRIEEPNKRNNLKTFKLKIHNTINPYSSRGLETHRKQLEAKNTKLSWDILKALNRADRITAKESVKLAVYLMMSINIAHSNEVEAKIEEAKKAVAGQSRALKDAEKKHKHAHRSGHNSQDEHSLSRNSSRRRPKRSHTDENGQNGEDGESNDGGENGESNDDGESNDDGENGESNDDGENGENNDDGESNDDGENGEHGESNDDGEHGESNDDGQNGEHGESNDDGQNGEDVESDEEVESDEDVENDEDEHFDNDEEEQDQDFDPSSGPQMFERGSFKRSGKERHAMSPIMERSYSSSSNRSSHNSCSSRLEKCPTKRKVIEKQVMLAKSKSHRDELVKSQKAVKNSRQYLHLQRSKSGNGFFAVSLGDIKAKAKGNEVYEVINEQIREIAKQQQLPKNRLNDDQVETLVEKHMREVFAEGPGKQFLLNMIELSKQMTAFEIRQCAEKFSWFPGCKVQINKKQITQNGLSKAPPPVRLQINSDSEEDEPSPQLLSRSASAASTSSTQRRADGSRLKSKSTRSGGKRDHKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUL8</accession>
    <name>A0A914HUL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4328.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4328.t1"/>
        <property type="gene ID" value="Gr19_v10_g4328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4328.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23782" checksum="46F4F08DBC56C838" modified="2023-02-22" version="1">MLDATKGDVQKTLLEKELEAVGIRLNKRPPNIYFKRKNGGGLKFTHTVPVTHCHEKLIQMVLHEYKIFNADVIFREDCTIDELIDVIQANRVYIPCLYVYNKIDQISIEEMDRLARMPHSVVISCELNLNLDYMLEKLWEYLALIRVFTKRPGNAPDLGPEDGIILRGTSTVEHACHALHRTLVAQFRYAIVWGMSTKFTNSPQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVQ3</accession>
    <name>A0A914HVQ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GDT1 family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVQ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4212.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4212.t2"/>
        <property type="gene ID" value="Gr19_v10_g4212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="643"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="736"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4212.t2"/>
        </source>
    </evidence>
    <sequence length="1191" mass="132424" checksum="95B0645556337D61" modified="2023-02-22" version="1">MSNEKKNENYSRNRVGCTSDSLKMFYYAPSKFGFYHAFIASLSVIVVSELGDKTWFIAAILAMRHSRLTVFAGAIGALTVMTVFSACLGWVTQLIPHRITFYLSTALFAIFGLKMLHEAWHMSPSEGQEVQEEAQAEVQKTELDMDSAKYSALETGSESTENQGSSAWKIISFVSTLFVKSFTLTFFAEWGDRSQLTTIVLGAREDVVGVILGGIIGHMICTGIAVVGGRLLAQKISVRTVTLIGGIVFLLFAFSAFFVSTVVSFPCHPQQRSPCSTTRHKRRIHSIKTNNDPGGEEGRRKRLKTFVPCTEKVQRMKGLHNDARQCSTTHRQLDENGTPGAGLGNLCQMPSPVYSSKMPRHSKIGLMTSLPQNHRLFTKGELKNCLGARVASSFTSLFAPLRPIHPILPSSMALTNGVAEGEVELEVQKMDGAEEEEEEEAMLVKKELKLEEGEAEGGVEEETADEAAGDKTEDQVPDITNEDPMTTSMDGIEDIEQKEGEENAETVEKAAEDENTEAAEIPVDVYDEAAEGEKVPEAEQEETPAEEEHPEEEPLPEEGGVELPDTEEEKSKADEALQAESEPEAPEAESETEAPLETPVETEGEEPKTEDEQQQFELQAPPRGRPRTPNDLDELQRVEVEAAEVPSAADDVASVTGSRKAPSVASPVPATPKSAASTKKTTFEDEVLSVKSGRSGRTKSPKSPRSPRTPKSPKSPRKVEIEEPQPEEEDVGAAASKDEEEKQRQESFDARMREREEEEARWKRMTSWDKGEDGTAAVERKTSAVTAETVDEVPEEKFEAEPEQKSEAEPVEEESELEQKVEGEEEPKSVLEEVPVAEAESAPEEAETEEPKAEAVSEEETEAPPGPPRPERSPSPMQRREPSARDRDYMPYDQDTLHETVPARLPTATSFSSYSPAERETYKPISPWVDQSSKYRNEYTVGEPPVAPAAYTAFFDDLVATGPFASSLYSTSRLLERSRSRTRERRQALRSQSQARNYYRFASQYPAPLRTRDYSTPPSSYLTRAPTAASSFVSFIDNYGAKQYDLARSQSLHRKSVYNSNMALSRSVSRGGVDYYLGSGRMSRVESYADALHSRYEWNMPSSHDMYYASNRGQVGYAPLANYQSYVSGLQRSLSREKFQRDKLRNKYATVSYQLDQAVKQMDLLRSHNYSAMRSGSAPRTSVYANFYPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVV8</accession>
    <name>A0A914HVV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD repeat-containing protein 4 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the Mettl1-dependent formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the Mettl1-wuho methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for binding of nanos mRNA and repression of translation by the mei-P26-bgcn-bam-sxl complex. May cooperate with mei-P26 and nanos to derepress the BMP signaling pathway. May cooperate with mei-P26 to suppress expression of a subset of microRNAs. May cooperate with mei-P26 to regulate bam expression levels in germline cells during gametogenesis. Required to promote mitosis to meiosis transition during gametogenesis. May regulate germline cell division in part by regulating ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a heterodimer with the catalytic subunit Mettl1. Interacts with mei-P26 and weakly interacts with bgcn; required for the function or formation of the mei-P26-bgcn-bam-sxl complex. Interacts with nanos; may be involved in mei-P26-dependent derepression of the BMP signaling pathway. Interacts with Myc; the interaction may be mediated by mei-P26 and may be involved in the regulation of ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4257.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4257.t1"/>
        <property type="gene ID" value="Gr19_v10_g4257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036265">
        <property type="term" value="P:RNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4257.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="43909" checksum="ED4759D966FB8F2A" modified="2023-02-22" version="1">MVVTIHLVEVDGQFFEVLCANSSVFVLKSSINNSLAELALRIDVSDLRSEGTQKQKKQPEIKLTILSSDVSANKKLLALATTAKRLALFDLSLLLKSAGNGIVSCDEAKWQTIQKTPTAIHFSASGEALLVSTRSGSVMEYRITGSDFSSAGIELVSHFSMVLDHCLSPGKPKFLLSADRDEKVRVSHYPNTQIIECFCLGHSSFVNSVCCLDDQIAISGGGDGILRVWKFKLGKCLCESSKLGDSPIRKVRPFHENGIIALSEGASKIFHFVFNPRGPSVELSRTFFADDQLFDFAVDEQCQRIFAVGRKGLFHCAFGVEVEAVVVRVQMESMPLGGDALLLLTELADRTDLFPLGELFKTVGFGNLEMYQRRKEGREEERKKRRKTGTNASSDSHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW70</accession>
    <name>A0A914HW70_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Apyrase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the apyrase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-I AFP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HW70"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4583.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4583.t2"/>
        <property type="gene ID" value="Gr19_v10_g4583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016172">
        <property type="term" value="F:antifreeze activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000104">
        <property type="entry name" value="Antifreeze_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
        <property type="entry name" value="Apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036258">
        <property type="entry name" value="Apyrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06079">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00308">
        <property type="entry name" value="ANTIFREEZEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101887">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0047">Antifreeze protein</keyword>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR609283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4583.t2"/>
        </source>
    </evidence>
    <sequence length="484" mass="53010" checksum="E9E11B53C5553927" modified="2023-02-22" version="1">MSANRISASKQFTAAFNISKDFSPIEKDFQNLLHLGAFMNDLDEMALRILTMDLLSSTGQNGTGWCKKKCGFGYQLAVIADLDKDSKVKGKENVWQTFVRRGRLFYDPAAGVVQSDPAAAATPAATAAATAAATAAATAAATAAATAAATAAATAAATAAGVVQPSVKIEWLKLETVEQKLSGNLSDKGRAMELSDLCIFDGHLLTVDDRTGFVYSLKSKAFGFKPNRNPAFFGSVSVNRDSLSQQPSPRGRRFSDNQPAALNPSMDNFTYMKPWVFLKDGPGTANISKGFKGEWMTVRDNKLYVGGLGKEWTTPNGEPVNNHPMFVKVITPGGVVEHVDWTKHYKALRSKAKIEFPGYMIHESGQWSDVHQKWFFMPRRASRNKYDETVDEHMGKNWLLSADAKFANIELREIGEIRGDGFRAFSAFQFLPNTGDDVIVALKSEERNGTGVASYLSVFRLSDNKVLLDDEKIASYKFEGLVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX13</accession>
    <name>A0A914HX13_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4812.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4812.t1"/>
        <property type="gene ID" value="Gr19_v10_g4812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4812.t1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45535" checksum="AA809B0C9FE77FF6" modified="2023-02-22" version="1">MAPAAKKKKLNCSISNQLHRRSSAASLCRFNAALGAGTRRSARIARKAPKRLGEIKVCDDVWLGIFPSLEPAEVGLTLALLSCRFDGLVDVHFRTRKFALGQLFIQQHSENGCNVKVTHIIKGIRMSKELPIPQTLPPINLIVFKCIYITHVNDNVIAFLYRIRSLCKSGITLSFRSKDKLSLNVITRHILPHFKNIIIAMRFNGNSVEELQSRSSPTVLLDCSNLRSIYWRGYFFTGQEFEFAVYEWLHSPRGDGRPKVLHCPFGDRMVDELKKKFRNAVTSVNYIVEYLDYFRPWKEQGVGPFELENERTRERLTFKYIFGLSCWVLRAPIARDEKQWTEWEMEARSVNEKKEKEISFVPLSRFEIGGSFSGSSDLGQLSVCAEPNFESPPISRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ23</accession>
    <name>A0A914HZ23_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A914HZ23"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5403.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5403.t2"/>
        <property type="gene ID" value="Gr19_v10_g5403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000084">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5570.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9401" checksum="3AC28CE2B17D449E" modified="2023-02-22" version="1">MSWVLMSWVLMSWVLMSWVLMSNYMIKHVIQHGLSEDRETDAQLHENLFTLVTDQKGNYVIKHVIEHGLPEDRETRCAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZS4</accession>
    <name>A0A914HZS4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZS4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5540.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5540.t1"/>
        <property type="gene ID" value="Gr19_v10_g5540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037387709" evidence="2">
        <location>
            <begin position="31"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5540.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30428" checksum="DB29567D423AD0A2" modified="2023-02-22" version="1">MRDFACFKLFQALFTVVLLCQLLSLERLCGKFIAPQCFVKSTAASGHCDKLTIFGLNMTDELEAMSDMEKWFKLSKSDQAISIDEKNFMDKIASKFPTRRQCFPIRVSLVSALKNAYDGVTADHMEKVADMLALLLCLGFVFLLVIVFHTLGQNSSEYDLFDYLCAVYGVIIWCYSTLMAAFLSDTWTTHWECTNFCPDNLRVLLFILVLSAVLLCTSLFEILFNRSLLQKSPITHSKSAVIKRTGDVKKNGVANAKNDEEVFIVRVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I042</accession>
    <name>A0A914I042_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I042"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5637.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5637.t1"/>
        <property type="gene ID" value="Gr19_v10_g5637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5637.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13259" checksum="64CA06D09E3DD5AB" modified="2023-02-22" version="1">MKSSTNNKQFVRIIRRTVNHLSKRKQKSPTFAIPVSPKKRPPQLGNMLGDSIEYEDEPKYELIEEVLQSILIEYNLNGLNYDWEDNRRQNPWQQPQHNNDLVSIYDGPMIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0Q0</accession>
    <name>A0A914I0Q0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0Q0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6224.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6224.t2"/>
        <property type="gene ID" value="Gr19_v10_g6224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6224.t2"/>
        </source>
    </evidence>
    <sequence length="813" mass="92032" checksum="AE29782B26D16FCB" modified="2023-02-22" version="1">MSAEIGRAFHILGESLLNIRLQGNKFSFDIIQSAFLKRKTPTTKGATERHPGEILSVEKAFAANGIVPDVVSKAPAKLVTAEFDGGLYAELGNELVPNNLTNAPALAWQAEEDKKYTVAMVDPDAPSRKKPANREWLHWLVVNVPGTDVAQGEQLTSYMGPAPPKGTGLHRYVLLVYQQKVGTVVNTNQKPVGRSKFNISEFAKKNHLGPPDADGVDRRSFDFRIKSFSNVRSSIACLYGSRTIFEVIEDGTPEEMGMAKALALSKRFIWRTMMEKWECHKLTRQETCKKYEIFSMAADAYVKSWECKHNGASSSTSSTNIHNNPKGKDDAYVKSWECKHNGASRKDDAYVKSWECKLNGASSSTSSANIQNDPKGKQKAMKSDAFAKSWEKDGGVSSSKDNPFKCLCVKPRFRVPQGELQLSSAMQINFENKEAWDLVDRWKMSYENGKESEKRKAAKILQFENAPARSESARDATSANLNAVKNKLTHTETKENDKKMEEFEKQLNKFEQKVYKLLNTKEDNIAMTELKSAHQIYVKLWDLVQECGLAMSAICEGVKSMGSPPAVSKHNWLAITRIGRLCSRCRTRVRRRSSKSFCTLVVLFVTIINKYFELSRAMTELDFDIEFLALSKKLENELKLTIMEKLPRRALQLNTLAIKCSEIVCQQRDYIRPPEKMTELFVEIRPIFVGIASELHLIESKLRELTADVKLASEVLISEKLAHCLSLTNELREKVESNLAVINKYHNDRAYYLNQMLRDPVAEYDLRVHSILQLELEKSRNLCMVLRRILAENLLHLVHNGQPKNAFYNNSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0T4</accession>
    <name>A0A914I0T4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0T4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5557.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5557.t1"/>
        <property type="gene ID" value="Gr19_v10_g5557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5557.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="28431" checksum="D58C0BD49EAB62E0" modified="2023-02-22" version="1">MRRIYPPDTDLNISSVDNPSVKDNPYNSSVEDNPSKDNPSVKDNPSVPNPSVDNPSVKDNPSVKDNPSVKDNPSKDIRSVKDNPSVSNPSVKDNPSVKDSPSKDNRSVKDNPSVSNPSVKDNPSVKDNPSKDNPSVKDNPSMSNPSVDNPSVKDNPSVKDNPSVKDSPSKDNRSVKDNPSVSNPSVKDNPSVKDNPSKDNPSVKDNPSMSNPSVDNPSVKDNPSVKDNPSVKDSPSKDNRSVKDNPSVDNPSKENHRRIVPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I128</accession>
    <name>A0A914I128_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I128"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5905.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5905.t1"/>
        <property type="gene ID" value="Gr19_v10_g5905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5905.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19514" checksum="43D905679CF2FF54" modified="2023-02-22" version="1">MMIMSLGDDGGRRNAVGEQDLPQIDGLTSEQVAEFKEAFELFDKNGDGRVTASELGVVMHSLGHSPTEEELQEMVREIDVNGNGSIELDEFVKMMSQKVKESENEKELREAFQVFDKDNDGFISPVELRFVMQNLGEELTENEVHEMIREADLDGDGKVNFTEFVFMMRQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1K2</accession>
    <name>A0A914I1K2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1K2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g646.t1">
        <property type="protein sequence ID" value="Gr19_v10_g646.t1"/>
        <property type="gene ID" value="Gr19_v10_g646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g646.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29775" checksum="E973F635334838ED" modified="2023-02-22" version="1">MQPNKLKFIQRLLIHTAQDDAIFFRTTEQRVIMSAPLIMPIIYGKKHCFCGIPVQTAARVIAIVNIAFCALGIVLAIYAYGPSTMMTALKWRNPKLYLPYLAVKGFFTLLGCLFAVFTLCLTIYVLITEGISKRGIMGIAACAVNCVFVPFCIWLYRLVWLAYKEAAGCIKSFAVGFSAEVLGEMSLPFGFSFSNPSLQTILVKADEPAVLNTNRSTSFAQWNEFELEMGISMEVNMVKMKFADLLIASAPSNLSEWKKYWQRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1L9</accession>
    <name>A0A914I1L9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1L9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6044.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6044.t1"/>
        <property type="gene ID" value="Gr19_v10_g6044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036928431" evidence="1">
        <location>
            <begin position="20"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6044.t1"/>
        </source>
    </evidence>
    <sequence length="556" mass="63884" checksum="1C8677D09322B6A8" modified="2023-02-22" version="1">MKSFLIFILFLVLPLGVELKNDADAIKVSSPQNSKAANSNTDGNELDKQMVPKQSNIFAKLSPKKLRSFRKSHQQDEQEVLHFDLSYSEVMVFEAFIVNRIRQSLIRPLVAGYVQITKYEPNTIYQKIDEIYASFPTEEGTKWKNIFGKFTQYLMEKTESYKKEHDEQIAPESVVFFQFDALLMLGESIFNVCLKEYKLKQNAMVGWWRSFRYELPTSKLIYYAPGSADEQPQLRQPLLQYCIWGRNFYRDNIQSIKKKGSELRKYFAIKVPKHLIQINLHVPEYLTEDGASFNPEDMPDQGENQDAAPIFLALYQLQSYDFIHASVIVGKLDINNFDSAPENCLEVHYSTGGIRVTELGEFGVPKKLKFFKVLMLKNVTTKFSVRQIESVLDYFALKYKKHDDINENCVHFISELINLISAERQNGTYPPETLNYTEYPVIYESDDETFKISNEGEEHSVNWKDNDFLKLPKIITAAQCTPKVREAAVLPASNAHCPRAAQRVTRGPSDAREPAALCAPGKAKRRQRVRAAMAAGGKRRWRANYTTLHAQLAFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2A3</accession>
    <name>A0A914I2A3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Strictosidine synthase conserved region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I2A3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6657.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6657.t1"/>
        <property type="gene ID" value="Gr19_v10_g6657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="4">
        <location>
            <begin position="172"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6657.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="43650" checksum="F9A6CE0269502130" modified="2023-02-22" version="1">MGKSIILFAGVVGILSVFLFGRPSNYDPIEYSLPPPPELKGELAANTHLRGAKLLLKGQILGPESLLVEGSDTIYTGTWDAKVVKIVDGAIQKSVQLPPNGRGKRPAKCATFDTEHLCGRPLGIRRLDARQLVVADSYFGLFTVDFDNDKEPTKQIFSPDSKPGGQKPMFINDLDVMDDGTTLFFSDSSNKFDRAHFLHGFLENRPTGRLLQLDLNTGVAEVVLSELHFANGVQIHPDKASVLVAECSMARIQRYYFAGPKKGQHEVFIDNLPGFPDNIRLTNDGTSFLVGLAGVRHADQLLPFVDMLGHYPAIRKFILQVVPERYLFPVMQLISKKYGFVLELGLDGKVLRTYQDPIGSVVSDISQAIDDASHLYLGSFHADFIAVIPKKGLQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2A8</accession>
    <name>A0A914I2A8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2A8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g666.t2">
        <property type="protein sequence ID" value="Gr19_v10_g666.t2"/>
        <property type="gene ID" value="Gr19_v10_g666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g666.t2"/>
        </source>
    </evidence>
    <sequence length="350" mass="40766" checksum="608737F13813E515" modified="2023-02-22" version="1">MSRKLYSLRTSQLVEDKLERFTSAIQKLLINLIVQIFLNGIKIWDKLQREVPSEKRQHIVQLIDYGKIGWNKYLATMEMGGAQTFYDCLQNGCFGNKNVEEFVREMVEPLKEIHQVAVHLDYKPSNLVYVMDMNTQKTLLKLIDFDSAVPIPLLNIWHGRANICEQPSPYAMITPTYICPEFYKANLVSTKTDMWAFGISVYELLLNQPMYRDLIEDVDSLIDNIAEIHRGHSIVKFEQFSIDFISDDWLEEPRYAEAIFHIIQIWTDFPQIALLIMNVLDTDIVTRMTAIGVLDYLDGNCCPSSVQGKIYPNQFKFFHKITFQQIRERIAKLLAQNDYEIVMRVSILAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2M1</accession>
    <name>A0A914I2M1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2M1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g628.t1">
        <property type="protein sequence ID" value="Gr19_v10_g628.t1"/>
        <property type="gene ID" value="Gr19_v10_g628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g628.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29525" checksum="F95ABE9D0EA79C33" modified="2023-02-22" version="1">MDTSQQQISLKFAPFPSVQSPPYSFTSPLHNHHHQQQQQQQQQQQQRPIIAEICAATGRPLEEMPADVRHDCADWRSVCSVLSFLPSCGRKREKSLVSFLSWKNAMEMNGAAVISVDERQKNERPTDSGWAPEATRLLGKELAITPSPTSFSSSSSSSWPLLLHLLPSPLPPLPPPPPGHYSFTYFLLFLLLLSWPLLLHLLPSPLSPPPLLAITPSPTSFSSSSSSSPGLTYFLPLPPPPPPPSPPPPHAFLPLRPIHLHVLLSPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I389</accession>
    <name>A0A914I389_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6902.t3">
        <property type="protein sequence ID" value="Gr19_v10_g6902.t3"/>
        <property type="gene ID" value="Gr19_v10_g6902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="397"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6902.t3"/>
        </source>
    </evidence>
    <sequence length="1518" mass="172619" checksum="E1378874993FCDB6" modified="2023-02-22" version="1">MQEINTECNYATTGGIGGNLLEHSLFALSIDNSSTKTFITIRGICKENESDKKRAGRSPQIYHGLVSASDTGDINLDTIRHDLDRARSERTNPTAKNVRYNQQLRRYLQMRNERESKPTKLELSKGLSVLVKRDGEEEAEVVDTPQPPAQGQRRITQTQQTSRPQPSNRQQSRKRKATNLRADDSSHIKKNLTTADREAIQRFQWQIGRKRALRRPTRNVPERDLVAEAAAAPIIDEDDDDDYLFENGSTLPAPSILHGDLPDDGDENSNDPSRRGTKRKASTLAEPKRQPATKIVHVDRKRKWTETHHPVEPEEKRARSNFVLMDSTNAKDKDQLPTTKMELVLDTLYNDPSSSAAFAGVNALWKEARKKIKDLRRKDVQNYLEGHRTYTLMRPRRVRFPRAKTVAAGFMTDVQVDLADFQTLARHNRGHRYLLVAIDVLSKRLFVRPLRNKRAEEMLEAFKRLIEQMPMAPHRIFSDKGTEFKNRLLKEYFEEQEIEKHEPVHSSVKASIAERAIRNVKQRLYRYFAQKENLNWVDVVQKIVDGINRAPSRVHGMRPIDINFQNAQQVWKRMYGKQVGNKRQRFRKDEFVRMTREKGQFEKGYLPNYGDEILEVDEVLKKVRPVRYKLRDDKGEKFKGSFYEQELARFNGSWVCGLHSISYPYSWHTTIGTLDEQWIDIHFLDYNAILAEDRKRVIRIPVPKASHQKVEQLRDFLASTLKQQSQLVQSRLNSSPERQLRYSKLNLSLLLASTTQQNPMPHHDPYPQHQKHHIPHACNSKCNTNTNYSKTNPSRTGACKTKDNTDTTTTATTLSACKTKDNTDTTTTATTLSACKTKDNTDTITTPSACKTKDNIDTTTTTNTTTINTTTPTSSTNIATTTTTTTTTTNTSTNTSTNYSKSNYTSKTNPSTDTNKHSDYSQGDYNARQEQAKKPLSTYNLRRIIDAVKIEYLENIARFRVIFKERSISHLSFSPQLGYVLGFQDPQNVQGLTENMIIGNSLSSLLRVVSVSGATPGEYNEKIYDSPIFARVLPREINEIEIELRTMDKGRLVPFAYGTTLIVLIFKKRGYGIQRGAGVGDVFRGLWRFFLPILRRVGTTVGAEALNTGQRVLERVGNEGVPLKEAFVTEGKRGIDTVLEKGGLPKQFGKEFRIRKENATGQLINLEADDQAVCPIQMIGQTFIRNIRMSINGREIFNTNSLMAYKIYFSHELSYSTTTKDSHLQAAGYYRDPGLTLEDGPGCVARRNLFAGSRTAQFIAKIDADLFNQPLYLINFCELDVEIIPNDNDFVLIGLNAPVRYRFELTGLKMYVKKVSLMDGLALDIARKLELKPARYAVRKTMMKSMFISQGRFEFTSNIFMDQIPRRIILGLVANDDYVGTSARSPFNFQPFNVREISIIANGRSYPQAPYDLDYPNKKYVRAFNDMNEAVGFTNTTESNGITFEQYGKTHCIYVFNMTSSGDDQAGLFDLIKNGTTAVCIKFSQAVPFGGIMMVVMGECDALVMLDKNRSISTDTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3I2</accession>
    <name>A0A914I3I2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF38 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3I2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g649.t1">
        <property type="protein sequence ID" value="Gr19_v10_g649.t1"/>
        <property type="gene ID" value="Gr19_v10_g649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g649.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="37132" checksum="866275474148B3D7" modified="2023-02-22" version="1">MPMAQRLGGREAKLKEISICADFLFEVFEFCGPFVLGLKVALISDRFELLVDAHFNSREWALGNLDIRRAIKGNGAEIVKLVDDKVERRLPILQEPLFDKVVGFKSLQISYIDQTVIDFLKIIRHKGANFYIETSSFEFERLRQFSPTVLRDCPKLRMIYTLDLSPAFPADDSAGSSLARALTKWLHTPRGDGLPKVLKCRRFPLEKIEGVKMEFDNSIAPVNFIIRLWQCPYNVTVPFELKSNLTGERLVFRRFDRGNWLLIRCPSERDEKKWAKWEKEAAEYEWSWRLWNHFIVDFEDGDIGDGLVEANEGPSEPVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I431</accession>
    <name>A0A914I431_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I431"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7316.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7316.t2"/>
        <property type="gene ID" value="Gr19_v10_g7316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF523">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7316.t2"/>
        </source>
    </evidence>
    <sequence length="816" mass="83396" checksum="61F5F9D8600AFE57" modified="2023-02-22" version="1">MGTIGDAGGNNGNLMGRWGATSYILGQVIGSGIFITPTGILNNVHSVGASLLIWLVSGLISILGALCYLELGTSIRKSGCDFAYLCHMRWVALAFTFMTCVCIFMGPGSLAIQAQTFTEYFIRGLKLEFCDPFVRSAAHKLITFSVLLLLFVLNCFSISGVVSRFQIISMIAKVAACTIIVVMGALFWLTQGVRSNNFSVPFDNSNFAPGKVVLAMFSGLFSYGGWEILNNGIEDVEHPHRTMPFAIIFGMSIVIVLYMTINISYFVVLSVPEMQRSNAIAMTFSEHIFQGYLQYLMPFLVCIVLIGRLLWAISRDGYFPSFVSCINRRHGSPRAALFIFVVLAMLFSFLGDLDELIGYVEFTNWVVRGCTMVAMFCIRCGHRADSIHPEAIRVPTALPVVFFFVCLSLVLVTIARSFRAALIGLLFLGAGLLLYLIFVWPPALRRFAFYRRVSHQINSKTSAVAQIVFDGSIEVRDRQQQKEDELSSLAKLCHKDSRRPRKRHSNADKNSTFSSPNQPKSSSTSRHAMIAPTRCVLLVLLGATMAQAFLSAFDVAPNALRNRRNCGCGCGGGGGGGGCSSGGSSGGGAVQLAVSCGGSQGGGGGGGGCSSGGGGGCGGGCGGGCSGGGGGGGCGCGCGGGGGGGGCSSGGSSGGGSVQLSISCGGSQSSGGGGGGGCGGGCSSGGGGGGCGCGCGGGGGAAAVVAAAAAVVVAADAAAAAAAVAARCNSQSAAEVHKAAEVAAVAAAAAAAAAVAAAAVAAAGADVASAWPFASALRALLAVSERKRRTISSAISFKIAMDFQVKVEPRPFGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5I2</accession>
    <name>A0A914I5I2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7701.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7701.t1"/>
        <property type="gene ID" value="Gr19_v10_g7701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000100">
        <property type="entry name" value="ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF342">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="842"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="940"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="161"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="457"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="800"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1119"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7701.t1"/>
        </source>
    </evidence>
    <sequence length="1357" mass="151811" checksum="7A8D6F9BBDED1E7E" modified="2023-02-22" version="1">MDGSSKSPEKLSSFVNRQFFWWFNSVCALGSRKPLELSDLYALNPSDTCNELVPQWERLWKEAIADYNKKKALQFPDELCGRSKESANGMDSKEVVQQQQEVVIEESDLAPLIRHDDGPNSQDTMASYGSTQADPSSVSKRKTPPPSLIWRLILLFRWNIITAMVMKCFSDLLTFANPVLLKDLIAFTENPETPLWHGALLAVSMFVASELSSLILNNYYYLMFRLGTRIQSVLVCAVYKKALRLSNSARRQKTVGEIVNLMAIDVSLALYMLWGQIGVSVLSGMAVMVLLLPINFLITMLTRKYQIRQMRVKDERTKMVNEVLNGIKVIKLYAWEPPMEEVINALRSKELSMIRKAAFLRTISDMFNSAVPFLVALSTFATFIFIDSRNVLTPQIAFVSLTLFNQLRQPMSTVADLISQTVQVSVSNKRLKKFFVAEELEEYVEKRPIEKNTENAMEVQNSFLTWDIALNSPSLKNLNMEIQRRKLVAVVGRVGGGKSSLLLALLGEMERIRGRIGVYGRVAYVPQQPWVQNNSVRGNIIFGSHGDEHFYDKVMSACSLYQDMDILPQGDQTEIGEKGINLSGGQKARIGLARAVYQNCDVYLLDDPLSAVDSHVGAQLFNQVIGPTGMLRNKTRILVTNEPSCLKYADLIVVLADGRIISEGTYVELTKNGTLARLMEDVESDRVKSVSAPMAKDGEDDNISDDTDETFMDENAADVENLLGTSAMSTVSGILARRKYSTSSTMYRRQRLTRADSVISSYNYPPVQRLLTGVEKVETGRVKPVIYMHYFQAMGFSLSVLFLLGLTLSTTASMSRNLWLSAWSNDQSPTGVNGSQPVSVRLGVYAAIGFLEVAVLFFGMTALLFGGVSASRNLHAPLLRAIFRAPMLFFDTTPFGRILNRIGKDIETIDVLLPYNLQFFAQCVLQVISTLIIIMISTPIFGIVVVPLVIAYVHVLKYYISTSRQLKRLESITRSPIYSHLSESIHGASTIRAYNQTERFSRISQQKIDAHVQCRYLSCVANRWLSVRLEFIGNCIVLFAALFAAITRGSTSAGILGLSVSYSLNITFALNFAVRQISKLETSIVSVERVKEYADVSTEAKWKVPGREPPAGWPNRGEIQFEHYSTRYRPELDLVLWDIQATIRPAERVGIVGRTGAGKSSLTLALFRMVEPTGGHIFIDGVDIAQLGLHDLRSNLTIIPQDPVLFSGTLRFNLDPFNRHTDAEVWESLEHSHLHAFVTHLPKKLLYPISEGGENISIGQRQLLCLARALLHPSRILVLDEATASVDLATDALIQETIRQKFNHCTIFTIAHRMATIMDYDRVIVLHRGRIQEFDTPQNLLALPNSIFASMASDAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I612</accession>
    <name>A0A914I612_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I612"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7834.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7834.t1"/>
        <property type="gene ID" value="Gr19_v10_g7834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037057079" description="ER membrane protein complex subunit 10" evidence="10">
        <location>
            <begin position="23"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7834.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23390" checksum="999EAC53EF24C9FF" modified="2023-02-22" version="1">MAAILIMSCSAFLLNVLAIAFAQEWSVDLNYSLGGGDFLSFGNVLVRKNIDGNYTGDFVPSRSLNDILKSLENAAEKPEDTIYKMRSGNAFSSNSLKVFSCSKFGHLIELAIDQNSHRLLSITHYPNPIKNPTGELRIDVRVKQTREISGPDTAFYLHRIEEEKRARQHGATQDNRSFLQKYWMYFVPVILFMVLSNAFTAEQQGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I727</accession>
    <name>A0A914I727_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I727"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8104.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8104.t1"/>
        <property type="gene ID" value="Gr19_v10_g8104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036995462" evidence="3">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8104.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20876" checksum="CA10735CFCDD8457" modified="2023-02-22" version="1">MGMLRLFKLLHFFSTIVGLPILIRAISSNCFYLPHISLNGGTYDEFNASEIKHCCIACARDACCIAYTYDKELGRCFMKSAISDSYKHSGMTSGLKANTHAGQGALLRNIRIAGGTASAVVHLPNTEDCMQYCTAYGIFSWSPLPPSATASTTPSTNDRSPSIQGECSCMSRISSLEYSFGSRSAIFPPVSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I759</accession>
    <name>A0A914I759_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein Abitram</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I759"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7532.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7532.t1"/>
        <property type="gene ID" value="Gr19_v10_g7532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039169">
        <property type="entry name" value="Abitram"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651:SF0">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7532.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20736" checksum="BE442BF2E94CE90A" modified="2023-02-22" version="1">MNFIPDRASSKSGWVFLPLPTIILRSLSAIFRHFRHALMLDPKNIVQVLWDPSSATGSSSAAKAKGKKRGVDRSKLAPSGKGKKGGLPMLPETRICIVRDSDGTEHIIRAGIRATLLEVNDERLAQEPNLMRTAADNHGFIAILMPPMGGDWRNTNIPKQFNGMEEMRDSDRRSTEMELKECKEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7F8</accession>
    <name>A0A914I7F8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3 14"/>
    <dbReference type="AlphaFoldDB" id="A0A914I7F8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7613.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7613.t1"/>
        <property type="gene ID" value="Gr19_v10_g7613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000147">
        <property type="entry name" value="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF30">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="13">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7613.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38287" checksum="E5594EB4D6615B70" modified="2023-02-22" version="1">MCRTDPSSSSSPLPTPSSNLFQSPHTPSLSFAMFSGASRFALLLPFKNSTTKFFHQRVPPLPLRRLAHRILSVTISLTLLLTIWRLWHWNNERWSSRTTVILITPTHKRPERLADMTRFSQTLMHISDLHWIVIEDANATVKAVERILLRSAIPYTYFFATTKPGFPKRGWTHRNVGLEYIRKHYAHFGRNAVVYFADDDNSYDIRLFEQYIKRVRTIGIWAVGLAGSALVEAPHVENGTITKWDVVYAPKRRFAVDMAGFAINLRLILNTNASFNLGCVRYSPESCFLAQFGIPREKVEPFGWNDEPKEVLVWHTKTKNIGTKGETHGYVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7M2</accession>
    <name>A0A914I7M2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Thymidine kinase</fullName>
            <ecNumber evidence="13">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>thymidine + ATP = dTMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19130"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer. Tetramerization from dimerization is induced by ATP and increases catalytic efficiency due to a high affinity for thymidine. Tetramerization is inhibited by phosphorylation at Ser-13. Interacts (via the KEN box) with FZR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914I7M2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7662.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7662.t1"/>
        <property type="gene ID" value="Gr19_v10_g7662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001270">
        <property type="entry name" value="Thymidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="THYMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441:SF0">
        <property type="entry name" value="THYMIDINE KINASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7662.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24891" checksum="1E5A9D9A26A688C6" modified="2023-02-22" version="1">MSECQCHQRGSIHLIIGPMFSGKTTELFRLAQRYILAGRKVAVVKYALDTRYDETHACTHDLRKMEAMSATEMADAFDELRKFDVIGIDEGQFFKDIVKYAQELANIGKTVIIAALNGDYRQEPFQNVAMLIPLAEKIEKLSAVCRCGQSASFTFRMSECTKLEMIGGQELYRALCRACVNEYSRVKEQLLNERKNGGVSLGKKRTATDPITHPIPQIDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7W2</accession>
    <name>A0A914I7W2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7W2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8103.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8103.t1"/>
        <property type="gene ID" value="Gr19_v10_g8103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053880">
        <property type="entry name" value="GPR180-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF24">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21892">
        <property type="entry name" value="TMEM145_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="876"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="915"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="946"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="990"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1084"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="135"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8103.t1"/>
        </source>
    </evidence>
    <sequence length="1157" mass="132217" checksum="EFDE3017775F9ADF" modified="2023-02-22" version="1">MLRNVDQKDGLYEDWLETIRREGGQFAWIRLNGLSEMHNRGRTTFQMREAVFSSKRIRDTIGALSAERGEAESVVRSEAQQILSTMALDFRFHSVTQPIGYSLAKIFERIFSHIWVNSAQMCQIREISSDRSVPVVWLPTHRSYLDFLLLSLLSYHYRIQMPAICAADDFRASRLLGEALRRCEFPLNDLLYRSIFAEYVQQLLLHADRPIEFFVEGQRSRTGKSVYPRIGLLQLAVEPFLKAQLYDTILVPVTIDYDRILEQELFAWELIGFSKPRETTMGLLRARSILADHFGDIRVTVGEPISIRKYFSEQFGGFDVRLELANQSSPELGENIRKKVRALALEVVHIQNANGTLTIWPIVALAILQTLNEFLSNSSSGEPLVINLDSLAQKSETFLRLFQKCCGLRIWRRGTKIEAEILAFVRLHKSHLTLSPSGDSVQLTNISPDDFPPLLLNSILLANQANPFVHKLAPFCLGAIVRLSGGDQSGNYCFLQRLFNQEFVHSPAEFVPLDQLLANTNTSDLWALAQILKPFLIAYHSIFVVLLTNCPNALLTAAELTRIIHRKLFEMVRHNAKVPMQIACTDIVKNALSSLNGFRVTELYDERRVRLNCAELPKFESIRSSAFSPLAKLRVSLPRPAVLPLLRIGCNRIRQFSSPDGPIHRPVHHTHQLRLCLFYVTVNIAPVHGTCGPHNGRRTYSKTTIGAEMKGILGAKLSQGVLSTTKKWHYLDRFCFVSKDGNLQYTVQYPKSFELQSIYLYYDANSQWKVAYGNNSLDCRQRERLLDPQNHQIIRLSPNAQFIDDRSKCEEISRGNNDSWIRCHGIRSFFSMRPRWWYLAVGNCDSEHGLFIDYSLLMTNAPPKNRWQRHFSFDQFYSLPIALAFVLLDAAICAVAIVFACMLKSRKMFHVSYRLFLHSLFCEFVSGLFLWSHLEKYADDGFGFPMLRLLSTIIRQFSIVFFVLLLLLVAKGYTITRARISTCSSVKMTLFVTVYLALRLAMLIWEIVVMTYMSESVPAYLIASLSLVAWAWFLRSSLATVKKYPRKKQFYAVLALFATLWYWSGPVVLVVANWVLDNWVREEVVLGVDSAVVAVGFIVFLALTSPLTNNRFFPFHVRTNQIGVNWNNFPHNVYEVQYTSGSPIRTVTTTGEPMNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I828</accession>
    <name>A0A914I828_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piezo non-specific cation channel R-Ras-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I828"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8154.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8154.t1"/>
        <property type="gene ID" value="Gr19_v10_g8154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="2">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8154.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17542" checksum="FE8AE000C6D340BA" modified="2023-02-22" version="1">MKLSPQSQQNASYWTSQVGLHPSMIPYNILEPRNVTYGTDRSLHFTEFVAFVDRVFPSWLDSYVQGGIVLMYAGIVLFVGRLIRGFVSSQPLDVIINEIPNPDYLLKICLDIYLVREAGDFLLEQDLFAKLIFLFRSPQTLIRWTRHKAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8B8</accession>
    <name>A0A914I8B8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RFX-type winged-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8B8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7574.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7574.t1"/>
        <property type="gene ID" value="Gr19_v10_g7574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000422">
        <property type="entry name" value="DNA-binding protein RFX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF33">
        <property type="entry name" value="RFX, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="173"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7574.t1"/>
        </source>
    </evidence>
    <sequence length="807" mass="88746" checksum="ECA4416BE31238E2" modified="2023-02-22" version="1">MFCGPTVEPQPPPPFWERPVAAHNGPNTGIYVVVVGGNQINQIQHYQPVQQQQQSSGGNTPPALGQTVHTTYVLRQQQQQQQQLHHPTAAAVQQHFQRHRQRTEQKQSLVVVVEAGGSDRDDEHGNNIDGNKLGDDEDGIAGDGTEDDMALLAEDGAQEAGGSGHTTRAAPETLAWLHANYESYPGASLPRCTLYEHYQNHCREIGLSPVNAASFGKLIRNSFKDLLTRRLGTRGNSKYHYSGIRIKPSSALLQEGFQRAQQNGPDASAPDEQQRHHSTARGTRRHGTRRAASHQQQAQKSAATATEPNSNSSGGTIDVAMMELDGTGAAQRQQRGQSADFPLPDALSTPADSLPFPRISLPLDDSLDEALLPLGLTIQHALKFQMDYEAHNREVLECLRNLRLESVESVWARFWAGASESDHAEGAVGEEELLPGGHQMQLSREVLYRLCTVPQLLGFVQHVDLCFYQLLLDQLLPDPLRPSLPAHAHGTAHRHQLLLPQMRPFAKNLCACMAKALGDGAPSALRELKLAGVRLLSNAITRLSSVAHLAVTAREVLHSDEQMAQMHADFDRLDFPVLHEQAEWCCDWSPSWLRSLEQQFGAGLAQRRRLEDWADWLDDLAARALQSLAPLTTTRSQKTPEAQLARGKRLLLAWTFWSSLVLRDFTLRSAASFGQFHLIRLLFDDYLSIAVERRLAQLNGQPAIALMAPEWLQLRPSPFALPMQPQQQHVTVPNTAPLYCSHPPPPTTVSIDFGSTTAVLWGPSSSAIIPSKQPAASIRGSVTAPGARAAVGHAQRLGRNSQRVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8H3</accession>
    <name>A0A914I8H3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DONSON family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8H3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7617.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7617.t1"/>
        <property type="gene ID" value="Gr19_v10_g7617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024861">
        <property type="entry name" value="Donson"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972">
        <property type="entry name" value="DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972:SF0">
        <property type="entry name" value="PROTEIN DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7617.t1"/>
        </source>
    </evidence>
    <sequence length="564" mass="61418" checksum="E669E8306D11E689" modified="2023-02-22" version="1">MASKTSALNAIEQSPSWEKSREAIRRPIKKRKSRRCLAEELAASSTAVRSPAFLPPIDWDDSAARSPFDCAASEQIGQCPDDSTAAATFTFSTVASLDNTISSLYPVDFSHFNVNSAGNKSSSKSLSGGVQNSELKNVSARPPRDWRLGTRLRLVSDQPFPWLTARQSNTTGNYPVKLSETVFNNQENQQMASLPLASLQNAILFRQFPSIGAVQMFPRRSATAQNAVLKSANLQSIEANFMDTLCTQWAQALLSLLRTVSSVPPDPSKHCPSFSEGFFYVCAPQFTALFAAVAAAAEQQRAPHLVVVITPSTSGFQQILRAKGIEFTLPFKAAEFVELGREDCPRDFLTNVGDESIGMDHDEWLRDLGISPRSTLKLKQSTSELDASSISHLSNGSKNDSGTSDVGKIGDENTRSLLGTPDESSKSTVLIRGIKNAEAFCRLLISQMALCSTKTGPQAGLPPTLISNMPFRHNTLKELSLTSQGPVMSSTVEWLLNFVQTEIAKPNRVQIHVVGRAQCNGLNEALNAAMNVRDGHEGFGGTNFAELECFQSESLDGERRFGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I976</accession>
    <name>A0A914I976_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914I976"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g844.t2">
        <property type="protein sequence ID" value="Gr19_v10_g844.t2"/>
        <property type="gene ID" value="Gr19_v10_g844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046349">
        <property type="term" value="P:amino sugar biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="398"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="569"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g844.t2"/>
        </source>
    </evidence>
    <sequence length="721" mass="80863" checksum="CB5F81ED75B178B7" modified="2023-02-22" version="1">MCGIFAYLNFFSPKKRSEIIDILLQGLRRMEYRGYDSAGIAIDCSNDANLPHADVAVYRKTGKVDVLAEHIKDIKGIDMDVSYNIHCGIGHTRWATHGKPKDENAHPQRSNFDNDFVVVHNGIITNYREIKDYLLSKGYQFESETDTEVIAKLTQHIYERHTRYSLRQLVEIVVQQMEGAFALAFKSRRFPGQLVATRRGSPLLVGIKSQSKLTTDHFPVYYSRPRRGPASLVFDESGTVTDTPTKLNISDVFGSFNAALNDTVTSTGHKTACPDSTRSVRPCDAANFEVEYFVASDASAIVEHTRQVIFLEDDDVAFVEDGALSIHRIKRSDDNTAAPTEQTRDVQRLTMELQQIMRGDFKTFMQKEIFEQPDSVVNTMRGRVHEDGRIVLGGIKEYMNDIRRCRRLIMIACGTSYHSALACRQLMEELTELPVVIELASDFLDRETPIFRDDVCFFISQSGETADTLLALRYCKPRGALLIGITNTVGSSICRETHCGVHVNAGPEIGVASTKAYTSQILALVMFALKMSDDRMSMCQRRQAIIKGLNCISDQIKQVLALDQQVLTIANSIYKEKSLLVMGRGYNFATCLEGSLKIKELSYMHCEGILSGELKHGPLAMVDKDKCIVMVICNDNVYKRSLNALQQVKARDGRPIVIADESVPLEELEGVEYVLRVPRTVDCLQNLLSVIPLQLLAYHVAELNGFNVDRPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBS0</accession>
    <name>A0A914IBS0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8420.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8420.t1"/>
        <property type="gene ID" value="Gr19_v10_g8420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF250">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="13">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="12">
        <location>
            <begin position="193"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8420.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32901" checksum="AEACAA6195017DF9" modified="2023-02-22" version="1">MAEQIATTIRDNYSTFFPSNKEAKFAQKSNATWEELTFSLNANFASALTVKQVKEKWHNMKKDSKRRFADEKREKRKTGGGRDESQPQDSVHSAIVDTFGERASFSGIPGARSTPLFADFSAEDDLEIQALTGLEEKPFKLMKTEFGQSPSPGPSRMRRSATSSVTDLQRNNEFRTKTDFFNYCSLPCVLGAIDCTHIRINSPGADDEQSYINRKGFYSINMQAIVDSKCQFMNVDVSWPGATHDSFVLRQSSTWEFFESGRGGNSILLGDSGYPLKTWLITPFLSPVTESQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICM7</accession>
    <name>A0A914ICM7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein MON2 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8694.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8694.t2"/>
        <property type="gene ID" value="Gr19_v10_g8694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="228"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="352"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="989"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1244"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1622"/>
            <end position="1646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8694.t2"/>
        </source>
    </evidence>
    <sequence length="1768" mass="195424" checksum="E14281D5BD7DF93B" modified="2023-02-22" version="1">MASSVAPGIVQQNDPKKLVEYLMGDLRLLSTEAKKKYNHIKEAAESGLVKVRNISSSASSSDNLLQSFRSLCTEIVHPFLLGCSSKNPRLVQISLQSIQKLLQFLAIDRNAVPGIVNELWALTEAECEELKVLQTITTFVSTELLVTDWALAKCIVLAFRLNFSKDSSVINAASAAVRHLFSTVFERAFQEDGMRGVGTEEMKILPQQKNLAANVQQSLAPPTLRPAAADAFLLLRDLCILIRRENPTWLIGIHKITPILALELLESVVKFYPSIFFRHSEFTELLKGYICPQVIKLIVGEREISLSSSTTNGGVVPPSNSTQNRSLPISAALLTQQQQHHQQQHGQIVTKARDFPIMIRSMRISLALLTNYHSILASQNELILSILLDLLCMPTNSWEAAVAIEVFRKIMAQPTLLKWLCARDEGGKFVELLFSRLTAFLRRCLEEAANDSPSVREDKVGGQQGFIFKGVFLPFDERQLSQKRSILLDWLDKHSAERIPEAYCLSVGFATLVDATGAVCSAVEGELLPDKGSAEGEEPMPEGKNSSTASPEFDVAKELFQVAHPFLTSGLSTLLEFSVDDSVTEHLLNCLTSMITLACKLGNAEAKHSLLKAFCRAALPCQYFSRFVGSNVPAVSMQNISVSNGTAAGTLSLNDLSLKESSVEPTQVVAMGTVCPSPHHPSQYFNTTVMMTAKNLQVARLLINCVHVNAHLLGGCWEMVLTTIQHFVWIIGLRPTSMGTFRAGGETKPASEGGGIMSTTSTSAASTVILTTAASSELPDLNQQLNMLFESTSSLDEVSIHHIIAALCKLSNESMMVAQVSSRETSFFSVAKLLQTALVNLSRLHVFWRPVTAHLIELCGHSNIATREWGAVSLTQLVKSAMKQTLAEFRVTETNKKTPNVEEITKREQLILNPLAAINEIEYLDVRVKQLDCLMRILQADSRPIEAPLWSSVLQIVTSVVVPDSRMNTITDPQLIDQAFRVLSLVIKEFLTVVPFECVEMLVETDALYGQQQIHLNVALASVGQLWDISDFVRRAQQSVRKEEEEKAWLCIYAALGRLCVDARPPVRKSACDTLLQTVAAHGQALGTQRWAEMLTDVLFPMLDRVRHLTQTASTHRSNTSSLGAPNIMIHHSRDTESKQWAETSVKTLGGVVKIFNAQRPMLLQLGGFSDFWSQLLTHIELAAKADNAEMSLAALKNMQDLLFGRQQQTESSHQSIGVRGKQSMANVRTYTDLSANPSLPEPLWLVCWSFWLRIAQAIVSPDCPATLDFVAPSPHTPSNESPFIPSTKKHFVPGLYHLTTLLEMFQQLFHRVRHQIPVEDVRSQRLSQIFQEIAAIPLANDPISISAHNTAEQLHPAQESLLNSIRLVIQEQIESNSPLRPALPDLLRLLLSFFQFAVQPPVNKFSAVFSAAPSQKVVPNTNVQCPPSQNTILFAEVSLKTALEFYTKTVAFDEVLQQTVLTDIVKRLAEPLSLKYRCPSQSTWQLSATTLIKACQVGFPIARENVNLFKGLWPAFAMAIENFLFSPSKSAHPLNADERKRHEFIDCLAIELIRTELLPYAATLPREFMQRIIDILNRGSINTMDSHDVLASDAYQQRADLSRVCFDSLLSLSQTDATTAAATATTTRHHQQKSPTTSSSSGGGFLRNTSQTTAACSSLGATAIASLLQRCSKVLNDYAKDEQTAGHFRLPQERIFESISALQAITALIEGFSRNPNNPTLYSHLVTLHPSLVQLIPSSRGDHQVELALMTCLNSYQTLLLLNLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICV7</accession>
    <name>A0A914ICV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-CAP/cofactor C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8721.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8721.t2"/>
        <property type="gene ID" value="Gr19_v10_g8721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="822"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="868"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="932"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="4">
        <location>
            <begin position="1514"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8721.t2"/>
        </source>
    </evidence>
    <sequence length="1875" mass="210923" checksum="1270FE45F41E9B4C" modified="2023-02-22" version="1">MTHPKNPPQRSGRDSKLSTQQPMEFERNKECPSSREWADISFSHTAKRGASSKPTIGLKLKLRFLALLGNCSATFSTKKDEERSLLRIRFWLVVVAGGTASTFGILANALLTRLFLTRPAFRHSSFFFLGFVALFDTLLDSVYILLLLIFFDKTTYFLHEPENNLVQSQLRTTAAQVMPKKKRSAKRRVDFVSQPEIYEITPLTDKPDFESPVNGVLPSSNGLDHDKDSLELIVEDSADSSSLLAMSMTKVPPKKGTDSVSRRAKVFRGAIPKLNLCENNGIEQSCQNLKANEKTSLEDNSLLSPYELGAFKNGSFMKAKAASQLWSSLFCPQDKEDIFSKVAYSKLNAWLVRWLERLKKKQQLEGECQQKGKKRRTDEEEDDEDACFDSSDEHLDNPAILAGPTGCGKTAMVYCAAKSYGFQVLEIPPYERRDRHFLEQKLSGASATYNMNVGANMQDIRNMFNPKRDSPANQKRKMSVGFTLILIDECELQYSSDYNFWSTLKQFCANSLVPIVLTCNDYEIVRRSMLNREPTLDTFCTIHFNESPTFQSFNAYLRQWLIGFTGKLRKNLYLRGLFEQKCGDFRAILNALQFDSHYTPSNVKPSTIGREQLSLKEFVCRAERTSTVDAMCGKSNAILWRANQMADLDYKREGLTGVWTTRVEQMDEIRSELLSLLNCDGISRVVKPSNAVSCAALQRSYPDRIYASCETSLDYLPCLLMIDKFALQSRVSRRQLHPFETVDPESGGKIDESHKLKYLLDAYKQLQLVRLYLSWLHHFKWLYLLGQIFKLSSVLCLIIASFERYMITSHWTFSGFEERTRWLLLSVVLFVSVGIRFSTSVDVVILFNEQSLVPFRRYSPAQITHREWLPNFFNLLTVIVPFGTLVFFNGGIVLMLRRQNVQQLRLMIVQLTMGYDFMKVRRRNIRSATNTLLLIISIYLISNLLSLFLSVFAFLNPGFLQKNYPQQYRIGSDCSSLLTVVGNALRFPAHFISNGEVREHFKLMCCPPKRKVLSVLGSECEAAKCVGTFGLRRESERLENPWFSALLTTRQSTRRTGGFVRSAGMGGRKSIILGGRRTQNRHCTAAYVKEEAGRQQQGFCAVCNGPIEEECCSGGALGTARDSMDEELFTGGEETGEDEERMMEEGRPNGRGVEENRESLPLLDLVELRFDPAEFSSIQQSVHSNRCLWKCSEYLSGTQLRALSLLIIVQQMTGEKESVEGLFFVDDCFGMSIGRPLHELVDESGVGRNSREELVSFDEFVRGGGGRRKEGDKVKRFDLRPIDDDEDGLNNDGFFDIVLGGASSVPEDPISPMGKMVADRMPRGKGGRSELYKVQRNISADSDNKGKWGNLEHREKEWGAMFANSATTKLRHSFCPTVGDGGGWLSGGRTRSGSHYSQDSAAYGYEPPEEPCPASSDMSKTDDLHKKGGGGKVLSHGSSSRRSVKGAERQKDGGTNVAEELHSQSQMMLSNSLSDLVLSKFLCCFRALNPTQMGRERKCGGGEAETTAEQNEQQHKYYSWDKRDDLCSNSADFRLANLSDETRVKEPGQLNGQPFQIEGCEDSLILLLDRTASITVDDSRNCVILAGPCQGSIFLRDCTNILVLAVCQQFRTRDCRQLIAHLFCATSPTIEETDVTICPLLLNYSGLQTQMHAAGLSPFVNRWSQVHNFTPETGKCQLAHHNAAPTAAFHNITLIQRLNDFLAHSSLLFMDGINGKEGDENKQEKALLLLQPVEGSNPGLRFYAESVEFANGLLSRENVRLVAMHDIDLRVGEWDALLPQHKQNKRQNKHTTDKVITLEVEGPAAVKQAAALVRSLPKTSSISAQLVEGEQMEQYTKQLYRLCVIRQNMCAVMTVEHTSRVILVMLIYFVSGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEU8</accession>
    <name>A0A914IEU8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEU8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9259.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9259.t1"/>
        <property type="gene ID" value="Gr19_v10_g9259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9259.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35552" checksum="D047C2F70030834A" modified="2023-02-22" version="1">MKASKVENFVKNDALASVEGRRRKHRHLFNFDVFVETENNRLIIISNQVFLFKPDFSRRYLINLGSFAPQGLWWNRRIFIESEKDSGNYHAFLYAQLDKENSEIQKKFLGYATLAKINDENASNSLSEYRLSIPINLTRFFNNKIIFTELNIYQYEESKYSLDTLKIANETKDMCIICLDPIIESQFIIKLHGENGDKSAHIFHKDCIKSWFEYCIGKLRCPYCNQELKSIMTVVVPPRFERVPDSFSNLYFNSISELFQISNGSNADDSFKRRQAEFGIKLIVTRLEEKEEKKNLLKLEAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEV5</accession>
    <name>A0A914IEV5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEV5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9963.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9963.t1"/>
        <property type="gene ID" value="Gr19_v10_g9963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9963.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16454" checksum="89388A4A89E40E05" modified="2023-02-22" version="1">MSDEDSEELVQQRDISKKRRIFTIDEKLEIESASENGKSRSKNYSLCGRLIVRLDGAGRHLRDKEFDDQMIAWIRTQRACNQRVSRRTIQIHALQIANQADEEETIFKRNYSEGIATNKFAEKYSSRQRFKLERITKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GNQ8</accession>
    <name>A0A914GNQ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GNQ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10023.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10023.t1"/>
        <property type="gene ID" value="Gr19_v10_g10023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037526693" evidence="1">
        <location>
            <begin position="29"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10023.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="15813" checksum="A6C1B974474E1727" modified="2023-02-22" version="1">MTLALPTLLLFTVVGIAFIQLFMGLTDGAVSCNLEGVCKDSPENGEGTVCSDCKSCTFKNCCNKVYTSQYAKCNIPGWKAANYVGSVPVDITAPKKRDAGCSDSNPCPDGSKCVAYKKGDSHGFCWRGPQGDAGNSSFALAILIAGLVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GP93</accession>
    <name>A0A914GP93_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GP93"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10158.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10158.t2"/>
        <property type="gene ID" value="Gr19_v10_g10158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10158.t2"/>
        </source>
    </evidence>
    <sequence length="347" mass="40139" checksum="CAE3A790C75B4793" modified="2023-02-22" version="1">MSDNANDEEQQQQIEKIFICTDIWHGVFAFLNTFELGLKMALISDRLDVLVDVHFKSREWSLGWLRIRRATDGNGAQIVNRSGDRLPIPEGPLPCNVIGFEWIEISYIDQTVVEFLQRFRRLFDSSGTKVWINTGYGQRRSWGIIWQKIWPLVTDNIRCFLSYSPPQFNRLRQFSPAVLRNCPNLRSIHSAGLFPEFPAEDNANASSHQAVAKWLLTPRGDGRPKMLNCDDLYLEEMEGLKRSFVNASEPVNFIIRLRFAGIESFELKNNLTGEQLSLRRFNKDIWLLVRCPIGREEDKWTNWEKEVAQWSWYGQRNCIVIAFRDSDIGDGVVEAEAGPSEPKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRU7</accession>
    <name>A0A914GRU7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase ASNA1 homolog</fullName>
            <ecNumber evidence="8">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arsenical pump-driving ATPase homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Arsenite-stimulated ATPase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914GRU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10595.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10595.t1"/>
        <property type="gene ID" value="Gr19_v10_g10595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10595.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37854" checksum="285783F181360607" modified="2023-02-22" version="1">MTEEQPLLESSLRNVLDNRSLRWIFVGGKGGVGKTTCSCSLAVQLAKYRRNVLIISTDPAHNISDAFNQKFSRNPTQVNGFDNLFAMEVDGSGLGEPSAPNLGSEDEKDVFAIGKNLLADFASGLPGVDEATSFSQMIKLIRSMDFEVVLFDTAPTGHTLRLLQFPTVIEKGLSKFLKAKTQFMPIISQMAPMLGLPDSSLDSTTDKLEDTLQVVRQIRDEFRNPELTTFVCVCIAEFLSMYETERLVQELTKQEIDVHNIIVNQLLFPDTNSDGTVSCKKCHSRFKVQQRYLAQIAELYEDFHITKLPLLEEEVRGTEMIRQFSERLVSPSSAAAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSH7</accession>
    <name>A0A914GSH7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSH7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10966.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10966.t1"/>
        <property type="gene ID" value="Gr19_v10_g10966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10966.t1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41366" checksum="80F78ADEEA66A6B1" modified="2023-02-22" version="1">MTLVKEYHNNQISSKIDLRNRLENIGVKLSLPTLDKYLGQIQATGGGSRKDPFTKELLKALNELNHKMCQSTMYEYLNRLKEEKKAGGGTPNLQAPHATAHLSNQSQSTELWDFSNPAPPLIQAPQIAQQPSNFTSGNPGSSTSASNKGKSTNFSKAPGASSHYGGALPSQQAPPMYGTDVPFQAGIDSTNWLEENSQNDDGSLYSVVNPKTPSSWKNTLGSLSNWFAQQSSNFTSGNPGSSTSKGKSTNFSKAPGSSLHYGGAMPSQQAPPMYGTDVPSQAGIDSTNWLEENSQNEHQTHPTLIRATPAHRRITVARYRFSKPQCRARYSQHSQISRPINQPHLIHPLTLCHPNLERLLWIGAGEIRKTMKEIFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSK9</accession>
    <name>A0A914GSK9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSK9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10003.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10003.t1"/>
        <property type="gene ID" value="Gr19_v10_g10003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10003.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21709" checksum="3273D1D3C7997208" modified="2023-02-22" version="1">MWHCDRIFGHHWGCVLYGTNIHLHLWCHCTCIATIIYLLFALIVHVKGRKVIAAGVANASLVNQRSIFIQVVLISCMNAIASAIYVSMNFVPLSEVLILAGQYVGLWLMNTKMHAHKSFFTLPDGATSIRTLETSRVTTTTTATKSIRTIMSQANRMHTHTQRLGSKSDEQIERVQMSDFIRTTLVNTCCKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSQ7</accession>
    <name>A0A914GSQ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSQ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10410.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10410.t1"/>
        <property type="gene ID" value="Gr19_v10_g10410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF3">
        <property type="entry name" value="TPM_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10410.t1"/>
        </source>
    </evidence>
    <sequence length="711" mass="79827" checksum="F0A481E119CD8448" modified="2023-02-22" version="1">MKNKDGIGDELQKILEVSELAGKFMTPSTSSHQQIPSLSQSPTFQQECTLYVRNLDERVTEKLLEELFTQVGPVNIVTIRDSQQQHKTSDTTAIPKAPANRYGFIEFADVESVLFACEVMDAVEIYGQKLKVQPRDNTTQKDIYAQLEMNKTSWERHHSSANNSKKSEMAEKSRLSTRHSDIGVYNELQQQPTAPAAGRQRVVTFNQIQGQFALPLMPLPQAQTMPTFPIHSNPKGGSRQHPLAMWSPYPSAQMQMDFAHPAGPSDLYPQMRIDTPIVRRINEEKGDRYKERPTKQANFRSLLQFDSRTYIAPIFGASCITFRQQPFRFIHSRGCSTAQLSSDEANAVGWEAMRREAVVLATAAAILLFSVLVTKVCCQFSPQTYPDPRIDPLSCRHLLPAQVCDPSEILKSDERRILNEKIVRLQQITANIKNSSPACADTTKSTNLYIMIALVDRLNALPFDAGSDHSVNIEKFTNQLRSKYQNYQDISLCDPLVLIVNAHGDRQVFTVAGRDAKLSREVLQAAFQRNVGHFRGGNYALGLEGMVPSLPGEPRKSKNESFVNGPSSVSSGMGQFVAHGVRQQQRLAVAEPKFDIESVPEGDRLWTRILAKAMAHCGEEPNKLVKYVRTAVEEAMDISLKLISDPHYNKIEEDSQNVDNGPNAREKAWQGLKSHLEDIYMKYGAQIQQIVTADQCPAKRGERTLRILRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT28</accession>
    <name>A0A914GT28_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT28"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10134.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10134.t1"/>
        <property type="gene ID" value="Gr19_v10_g10134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10134.t1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39008" checksum="A523CA0E80D4E98D" modified="2023-02-22" version="1">MSDNESESEQQQQMEEIFICADIWLEVFAFLDPFELGLKMALISDRLDVLVDVHFKSREWSLGRMRIVRAIGGNGAEIVKYRSGERWLLPIPQGPFPGKVIGFREIEISYVDQSVIEFLQRIIFGSSGTNVVIGTSNSQSRSWEIIWQKIWPLLNDNICGLLLYRSYFDRLLQFSVAILHNSVNLRSIGSVGLFPEFSAEDDADVSSVQAVAKWLLTPRGDGLPKMLICDFYMGGMEGLKEAFVNASEPVNFIIRPLFTGIDPFELKNNLTGERLTLRRLNYNWLLVRCPIVREEDKWTNWETEALLWAREPERNCITVNFQDSDIGEGMAEANEGPSEPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTW1</accession>
    <name>A0A914GTW1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase 3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTW1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11170.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11170.t1"/>
        <property type="gene ID" value="Gr19_v10_g11170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF12">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="67"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11170.t1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48073" checksum="47EE4F4B9DDF71EF" modified="2023-02-22" version="1">MLEGDANGGNFEYSLPFSVLFVWAFFVLLVVLLSPIRSTNVSLRIFNPRNALTALFRVRSPTEQRLAFLDLFRVWAICWVISNHLGNEGRLDTLLGLPHGSPSMPILFLAPSSGTLLWVVASSMAVPSGLLAEFYQILSASVASARTHNIGLRFIGHWIKSTCTSTLIAHALLLSNWSRPTCFSYLWHLGLDWQCHLLVPFLLHFLSRHRRAGLSLMIGLIIGSMCLRAFICVSNGICNKSDVDIPFFSVSVRPDYESLHEIYTRPTTKCGPFLVGLLIGLVTLRADNSPSSEWIEMLRLQHKTIFWYWYPDQGTTPYNTLYTAIFRTLFASGVGAMVIGYLFSVKSFAPLTQRLWTVLARLSFSTALTHMPVVFFFTHIAAFQESMSPFGLLVALPPAVLMSFVVATIFYCFVQWPVSQIIFHLTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU05</accession>
    <name>A0A914GU05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11223.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11223.t1"/>
        <property type="gene ID" value="Gr19_v10_g11223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037954131" evidence="2">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="327"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11223.t1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47220" checksum="45620033F9B7430B" modified="2023-02-22" version="1">MKRFLFIVLVLCAHGAFGYSDLNKTPKSVRWADACDECQMIIKRIVDVATDPTKVAELKLLLSALCQETSYVDECRLFVNKLDLFLDRLLPYLKNAHHVCKELHICDNNRLEQFHLLGMHYVRVNASFQRKDLICEECQLAAHELAREINVPKFQQDVEEWLQQNICAHFGSLKASCEQLLDDFLPEMWKELADMLGDQKKFCQDLELCPTYAGGYIRSPSSFRRLKSQFASSSMGSSDSRCPCFGHKLSINTFRLVFDHYVQNDFNTGPCALLTNGNDFCRNLIAGGIHSLVDEIMHLRLIQITRLKQICEWKQSRMLGFLRRATSKLHCDICRAITKLLEVELGKPKVQEELIDALERHFCDRIRSSDYAICVSVVKSYFPLVLTQIVQQLQRNELCHLAHVCPKPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUJ4</accession>
    <name>A0A914GUJ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUJ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10913.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10913.t1"/>
        <property type="gene ID" value="Gr19_v10_g10913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10913.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18944" checksum="47897396C798D3A8" modified="2023-02-22" version="1">MVLVSEFCAQLLSCQTKSLRDRLNHPGDRVLALNSVTGRKVRTTYKDRNGMSKTFFVGGITTKGAAFTPHMEDCVGRTIIHLPYVPCIIERFPSGGEDRFYPMELLELVEDEASSNWIGRMFKEIDTTQQRASSSSTTDSALRFRIDEEDEENTGRDECSQPTYTCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV53</accession>
    <name>A0A914GV53_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV53"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11474.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11474.t1"/>
        <property type="gene ID" value="Gr19_v10_g11474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11474.t1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34337" checksum="4322232ECA73BBA6" modified="2023-02-22" version="1">MDAHFESKEWALGNLEIRRAKKGKGAQIVKIVGNGIVERRLPIPQNPLPVKVIGFERLEIRYIDRCVIEFLKLISPLFASKGKNISIGTDYTHERSWEIICEKIWPLVKDNICGISVFSYELDRLRRFSPTFFGDCPKLRVFDSGFGFPKFPADDSAGASSGRALAKWLHAPRGDGLPKMLQCVCCMGEMEELKNPFVNSTDSVNFIIVLLSMDKGIVPFELMNNLTGERLELRRIDEFKWLLIRCPIERDEGKWAEWEREAVELGCFWQWNRIDIDFRDEGIGDGGRRKRRPRVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWU9</accession>
    <name>A0A914GWU9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWU9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11904.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11904.t1"/>
        <property type="gene ID" value="Gr19_v10_g11904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11904.t1"/>
        </source>
    </evidence>
    <sequence length="536" mass="59473" checksum="627F904016ED40D7" modified="2023-02-22" version="1">MRAFFYRRCTTSFSSCSTSTLSDGPGTRLQMESRTFGGGARRSSAMADGPGGKDQFALRGTYVIAVDVDPRSSSVTPSIRQLATPFAKVGALTCEEADTLMGAVLDQVIWSSIIFDQRGGARRPSAVAQLRLWQMDREPDCKWRAEPLAAVRDDLQQLLNFDFGRWTGNPTANGEQSLWRRCAMTFSSCSTSTLADGPGTRLQMESRTFGGGARRSSAMADGPGGKDQFALRGTYVIAVDHAGQSKRERSSFGERRWEEADTLMGAVLDQVIWSSTISDQRGRFFFSQLLNFDFGFGPERDAALVAKNVDAKDAGIVLIFHFHLLYNLLGLCSEERQLIHSMGLSEATLIRHIHSHNQQPAECEQGHAVSLRGRTSFQRVELSTNPQKGVLVIFMRRDFAPWQIELLALQEDDQQCKCLPPGLINGAERPSDHPRSNSRESDGIGGIGHRRNVFLPVNNCPTERQNYESPANRLPATIRDEIGADGHWNRHGHWNRHKAKATFRLILRLGLPPNNARLPATIFPITSDRAKGKQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX21</accession>
    <name>A0A914GX21_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GX21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11186.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11186.t2"/>
        <property type="gene ID" value="Gr19_v10_g11186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="232"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11186.t2"/>
        </source>
    </evidence>
    <sequence length="565" mass="64645" checksum="4B575A4986A1024F" modified="2023-02-22" version="1">MVKVWRRSVRENTKRRERLEKKREKRDSAPSNLNDGRQILSSSDSTNFRIKNDFNGNMDKSYGIVIDAGSTGSRLFLAVNDRQERPVVKKHGNDAASAYIKPLLDFAAEFIPEQKLGATPVFIFATAGMRLLSLEKQQSVMENLRKELPRMTKLQILDQHIQVISGRWEGIYSWVAINYMLGRFNLSNSVDQSDDEESRENLKSFGKKRISTSSVWERVQRPNSAGMIDMGGASAQIAYELPFADSEGGTLPKSGENVQLINLGCRDDDPRFRYRLFVTTFLGFGVNEGAKTYEKFLWKRLSGEWPMNSTEDAKMKVPTVVDGCLPLNLLKLTYVEENYSQFVRKGNGDWDTCVSDIATLLFESNSKCPLAKSCFFDGIQAPSQFVDDVLSLGGKYEHDKFERKAKEFCGQSWAVIKKKVKTQFYPKADSERLETQCFKSAWIHAVLHNGFHVDEVQHHFQSAFRINGQEVQWALGAIIYQMRYLPLLTENKGRRSMRPNRIYQQLLGGADVWALFYFLCILTLMALLLRIETTAMANPFTIESSETEWSMVQNPFCLWEENKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX57</accession>
    <name>A0A914GX57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GX57"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12170.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12170.t1"/>
        <property type="gene ID" value="Gr19_v10_g12170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12170.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39214" checksum="08DD48BEA079B7F9" modified="2023-02-22" version="1">MSDHPREAHRHLKKLKVCDDVWLSIFPFFEPAELGMKLALLSDRFDALVELHFKTRKFTIGTFQIHNSNCRSGVVIATYNIVDLIFMKFPIPEAPAPDNLIGFGCIYIRCTGLDSLDQTLAASFRHIRSLFKLGITLELDISDEKQKNFAVLVKEFWPLMATNISKLIIGNLNYVVQLRNYISPTFLHDCVNLRAIGTAEGLFFCDLPATPEEVSAEQAVFEWLHTPFKSGIPKMIKGDFTWTPQNFRKMEELKKTFLYASSPVSYIISRCVTFGGVEPFELENERTQERLTYSRRKLRSHVFRLLVRGPIVRDEKWAEWELEAMEAWTTKNKIYISYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX65</accession>
    <name>A0A914GX65_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol carrier protein 2</fullName>
            <ecNumber evidence="13">2.3.1.155</ecNumber>
            <ecNumber evidence="14">2.3.1.16</ecNumber>
            <ecNumber evidence="3">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Acetyl-CoA C-myristoyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Non-specific lipid-transfer protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">SCP-2/3-oxoacyl-CoA thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">SCP-2/thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">SCP-chi</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Sterol carrier protein X</fullName>
        </alternativeName>
    </protein>
    <organism evidence="40 41">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="41" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="function">
        <text evidence="27">Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:47400"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:87695"/>
            <dbReference type="ChEBI" id="CHEBI:87698"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:47401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:40343"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:77081"/>
            <dbReference type="ChEBI" id="CHEBI:77084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40344"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:62960"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:21566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31111"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:62418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="31">
            <dbReference type="Rhea" id="RHEA:31113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:16865"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57373"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58507"/>
            <dbReference type="EC" id="2.3.1.176"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:16867"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31183"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="30">
            <dbReference type="Rhea" id="RHEA:31185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31091"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:31093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:35279"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:71407"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:35281"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="29">
            <dbReference type="Rhea" id="RHEA:31205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31087"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:31089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:46344"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:86042"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:46346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:18161"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="EC" id="2.3.1.155"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:18163"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.155" evidence="13"/>
    <dbReference type="EC" id="2.3.1.16" evidence="14"/>
    <dbReference type="EC" id="2.3.1.176" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GX65"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11989.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11989.t1"/>
        <property type="gene ID" value="Gr19_v10_g11989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050633">
        <property type="term" value="F:acetyl-CoA C-myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000126">
        <property type="entry name" value="Protein CBG20965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="40" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="37">
        <location>
            <begin position="15"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="39">
        <location>
            <begin position="283"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2" evidence="38">
        <location>
            <begin position="450"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00032093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00045738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00045994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00049306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00049542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11989.t1"/>
        </source>
    </evidence>
    <sequence length="565" mass="61816" checksum="63F7E2807AA4D4B6" modified="2023-02-22" version="1">MMVASTQNVAKKPKVYIVGVGMTKFYKPKSSGKDYPELVREAVTEALGDAGVKYKQIQQATASYMYGGSCCGQRALYEMGLTGIPIFNLNNACASGSSGIFLCKQIIESGNVDLMLAVGFEKMNPGSLEATQGMEDDRTLPVDKHIQLMADTYGLQAAPITSQMFGNAGREHMEKYGTRREHFAKIAYKNHLHSVHNPKSQFQKKFSLDEVVNARKIYDYMGLLECSPTSDGAAAVVICSERFLEQNPQLKGQAVEIVGIELGTDEPTVFSERSNIKMVGFDLIKRISERLYTNTGVQPDQIQVMEVHDCFAPNELITYEALGLCPVGKAGELVDRGDNTYGGKWVVNPSGGLISKGHPIGATGIAQAVELSNQLRGRCGVRQVPNAIYALQHNIGSRIVIRSDRQPSPENGIGGAGVVAIYKLGFPQIADQPAREQKAAAKDFKSDAIFEEIRERAAKESELSNQINSIFKFVISRGADKREWTVDLKSSPPFVGNSPREKLSDQTKKADAEIALSDDTFVQMAAGKLKPDQAFMQGKMKIRGNIMKAMKLKAVLDPSKLKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYM0</accession>
    <name>A0A914GYM0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol carrier protein 2</fullName>
            <ecNumber evidence="13">2.3.1.155</ecNumber>
            <ecNumber evidence="14">2.3.1.16</ecNumber>
            <ecNumber evidence="3">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Acetyl-CoA C-myristoyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Non-specific lipid-transfer protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">SCP-2/3-oxoacyl-CoA thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">SCP-2/thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">SCP-chi</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Sterol carrier protein X</fullName>
        </alternativeName>
    </protein>
    <organism evidence="40 41">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="41" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="function">
        <text evidence="27">Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:47400"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:87695"/>
            <dbReference type="ChEBI" id="CHEBI:87698"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:47401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:40343"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:77081"/>
            <dbReference type="ChEBI" id="CHEBI:77084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40344"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:62960"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:21566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31111"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:62418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="31">
            <dbReference type="Rhea" id="RHEA:31113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:16865"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57373"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58507"/>
            <dbReference type="EC" id="2.3.1.176"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:16867"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31183"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="30">
            <dbReference type="Rhea" id="RHEA:31185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31091"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:31093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:35279"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:71407"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:35281"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="29">
            <dbReference type="Rhea" id="RHEA:31205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31087"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:31089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:46344"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:86042"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:46346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:18161"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="EC" id="2.3.1.155"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:18163"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.155" evidence="13"/>
    <dbReference type="EC" id="2.3.1.16" evidence="14"/>
    <dbReference type="EC" id="2.3.1.176" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYM0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11989.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11989.t2"/>
        <property type="gene ID" value="Gr19_v10_g11989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050633">
        <property type="term" value="F:acetyl-CoA C-myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="40" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="37">
        <location>
            <begin position="15"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="39">
        <location>
            <begin position="283"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2" evidence="38">
        <location>
            <begin position="434"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00032093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00045738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00045994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00049306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00049542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11989.t2"/>
        </source>
    </evidence>
    <sequence length="549" mass="60023" checksum="5F83F7E5676E5FB8" modified="2023-02-22" version="1">MMVASTQNVAKKPKVYIVGVGMTKFYKPKSSGKDYPELVREAVTEALGDAGVKYKQIQQATASYMYGGSCCGQRALYEMGLTGIPIFNLNNACASGSSGIFLCKQIIESGNVDLMLAVGFEKMNPGSLEATQGMEDDRTLPVDKHIQLMADTYGLQAAPITSQMFGNAGREHMEKYGTRREHFAKIAYKNHLHSVHNPKSQFQKKFSLDEVVNARKIYDYMGLLECSPTSDGAAAVVICSERFLEQNPQLKGQAVEIVGIELGTDEPTVFSERSNIKMVGFDLIKRISERLYTNTGVQPDQIQVMEVHDCFAPNELITYEALGLCPVGKAGELVDRGDNTYGGKWVVNPSGGLISKGHPIGATGIAQAVELSNQLRGRCGVRQVPNAIYALQHNIGIGGAGVVAIYKLGFPQIADQPAREQKAAAKDFKSDAIFEEIRERAAKESELSNQINSIFKFVISRGADKREWTVDLKSSPPFVGNSPREKLSDQTKKADAEIALSDDTFVQMAAGKLKPDQAFMQGKMKIRGNIMKAMKLKAVLDPSKLKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ12</accession>
    <name>A0A914GZ12_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein KRI1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZ12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1265.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1265.t1"/>
        <property type="gene ID" value="Gr19_v10_g1265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="4">
        <location>
            <begin position="353"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1265.t1"/>
        </source>
    </evidence>
    <sequence length="529" mass="61900" checksum="A801BCA02EB9F09C" modified="2023-02-22" version="1">MPDPKMSGNPASGYIREPRQENSSHSDGISANDIDYDDDHHNTEGGEDNDAFSDELSSSSSSSGDPTVWTADDERTFLKTLSALKERDPKIYSTDSKFFDEETKLPKLARNAVPNTKVKETRNKRQKMSLRDYERKLVMERGGELIDESDEETMPGGAKDGGGEPFASYSKQQEQLKNAFKDALAESDDSDAEGLLKKREKSEQEKLREEEDFYEWLRDEEGGSSAGILDKDLVNLKRRWSARGEAKLDEEERFLRDYLLNRNYKNDEDMEEENGERVPTYEEIIQEEEDEEMADQFEHKYNFRFEDPDQEFLKQYPRTVREALRKAETKRKRRRERLKEEQTKEERRERAKVQEVDIPFRYRPVLPNSFGLTTEEILSTDDRKLNAWAPIRRVNQYRSEEEERKQQMFFQRKSQHVEKKRKVLEERPFTLPKEQAPKVEDKKEEPNRNEEVAGGGEEAVTGKLKRRKKVVRRRMKKGRLEEDGRVDISDLGVRRLKAYGVSTKKLKRAHFSKKRAAESNREGPKAETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1M2</accession>
    <name>A0A914H1M2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1M2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13180.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13180.t1"/>
        <property type="gene ID" value="Gr19_v10_g13180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055987">
        <property type="entry name" value="DUF7565"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24446">
        <property type="entry name" value="DUF7565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13180.t1"/>
        </source>
    </evidence>
    <sequence length="543" mass="61072" checksum="6A9ABD29727CE9A2" modified="2023-02-22" version="1">MLNCQLCIDENGDGVQDAMKFSSLEQLEAHLAADHFSVLPYECEQCQFAKFPTEFAVMKHNEMDHDNQSYSFRCRITPDVKAKRQKVRECLLNVTDEKFPSNLHTNFNEGKLKEMLSSKTEARMKRSVKNGQNRTKDRHTINGGESSLEEQKNDRRGRLRRVSCGDNLEIVRGLEQRDASLSTEGEEADDAMEGQQADVQEILKATAAAVSQIGGSKKQLSLNSPVSLRSEAYSLRPNRFKPLLVVLGKWKAHHRPKEMVNARGGCLSHHTNARHLRLPMFQCALCKKDFFEVSNTQIQKHMSTHHKGEKKHLISNYHKFSAILHATRDECFGKKDERIRTLKSKVGRTPNVKGRAKSVIGMNGIGKRGEGIGEEDAVESGHSKSANDGAPNCLADGIDGQLKGGAEENDGSMPSIDKYSYLKSWAVRLSAEHQRPNQHPQQEASDGPDQRVSCKVCGEMVWNKTGNRLNHVNVRHLQLPLHECDICQKTFTSYSRSACYSHVQFAHKAQIGSGQGSNVIEKHIIYRKELHDVQLLEAAKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2E1</accession>
    <name>A0A914H2E1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2E1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12602.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12602.t1"/>
        <property type="gene ID" value="Gr19_v10_g12602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="99"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12602.t1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42774" checksum="8C48124877449598" modified="2023-02-22" version="1">MCEILDRDELMISEEIAIWNAALRWADEKCRQNGEAPSAENRLAMLGPALFKIRFPLIPQKDFSKIIVPSDVLTLNQMMSIFLHYSHPDADQPELYPLLFPTKRRTATKSPGDGLTSQNRWDSAAHHEDLTVIELDRLIVEHNGNIWARRSVFAERAMPKNSYGIFYYEVKMLKKIGFVWIGLGIKQMPLMDEWVGGYEGTYAYGSGGDFWGHAVEGCFYTAGRPYIGGKPKFEEGDVIGCGVNLATRQIIYTKNGQRLETAGLFVDSAAELLPCVTLSHPGLRRLDYCDGLLEWKKGETRRLSGRRRDKLSSNKNIKRPPVSKGLQCLYVKKGADGIGEMKSKECRDDDHYCFEATCAKGQQIKRPGVNLGNLDPKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2F3</accession>
    <name>A0A914H2F3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2F3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1305.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1305.t1"/>
        <property type="gene ID" value="Gr19_v10_g1305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1305.t1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42659" checksum="05BAE0C9DF18C858" modified="2023-02-22" version="1">MPSTANTWKKRNQIKVSNDVWWNVFEWILRAELGLKMALLSARFDAIVDTFLREKRWSLGVLKIIRRTEDKAGEKKIAIACFDGAGNIFRTFPIAERPLPNGVTAFERILLSHVDNDVVEFLHHLEPLFIKKGINLTLNVCHWTSGLPNWPITAPEVWPLVVENTVRLRIHDEYGLIAQNHRISPDIIRQCANLRLIDSRDLFPEGPADDGTASSPAQALSQWLHLPRGDGWPKILLCEEVWPFGEKVEGLKKAFVEASSPVNFIVRLSLHHLEGGPFELRNERTGERLTMELIDDAGGEEVQQGIEEEDAFDDDEDDRMTHYIPVKHKLWLLRRCPIERPKDWVHWEKEAIGWSWDSASNVIEVDDEHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2J9</accession>
    <name>A0A914H2J9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2J9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13409.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13409.t1"/>
        <property type="gene ID" value="Gr19_v10_g13409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF322">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="173"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="311"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13409.t1"/>
        </source>
    </evidence>
    <sequence length="522" mass="60104" checksum="EFBC1B47F70FF88F" modified="2023-02-22" version="1">MERRQKVILRSKEIGKTPALAQIRGVKWDDEFRRRYDEYEEGMSGEQSSGERETVLQKTMKYLKILLPHVGLNILLFTYISFGAIVFIFLEADNELEQRRSKVSQILHIYELIMNETVAICRSAGATSLSTLNGSMVERRMRPLLSVLSRTHEYDERFTSEAQMWSDSEDSLETKWTFAASSLYALTVITSTGYDHLTPLTDSGRIFTVFYGLLGIPLMFITAADIGKFLSDLVIKTYGKLLGICTWLLSVFDAIKDYIVQPDDESIESRKLRERRKRRRRRLDGGDEDEEDEDRERLQLPIFSYFALVVGYCAIGSLLFNWWERGAVWSFIHGLFFSFNTITTIGLGNICVTNRAYLALVILYVIIGLAVITASLDLCSSTLKKTFTKLHYFGRKIREIHGIHGLSRDMREAMKIISAMKKIRGSKERITLEDLKRFLEVQEHLLRQPYVPYNVHIFKWIEDAYMQYCLNNEETASLGGRSAHYKISPGKERLLPPPPPIMPNLHRSFTENSSAQNSVILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2R7</accession>
    <name>A0A914H2R7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2R7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13130.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13130.t1"/>
        <property type="gene ID" value="Gr19_v10_g13130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="766"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="167"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="263"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="366"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="464"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13130.t1"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112992" checksum="BB35F4DB7F92214B" modified="2023-02-22" version="1">MIETDQKAFEQIKHLSLSIGGQKPMKIIWARIGQPITLPCELESRGSEEANASESRGSEEANASESRGSEEANASESRESEANASDQLEWRKNGSLIFNAFGAEPGFFASAYQGRLSRGSGMDLAIHSVQLQDQSTFLCSISRFPRGKTVGGREYGKFIRLIVHLMPRILEPLDGSKIIAKENSSVRQNCLADGIPTPNIKWSKKRKNGTWETVGFDRQLRIEHFSSDNEGNYNCEAKNLEGTQNAAVVLKMRKPLRIDRENPSLVNKTAVEGSAVFWQCSVEHQKLWAAVGKVRVQWTKGGKAINQLELGLRAHLDDGSFGIMHLRRTDLGEFECTATFLDSTATADGLLESDSVKMNLNVQYRPEISPKTRRFYTLAAGASADLHCLINANPKPTVVRWTKNGRELTSHAEKSVESNLLQSTVNIPSAHLRDSVGIYTCEAKNAVGVTEPPLEIHVVVAEAPKFTKIPAPKYFVKAGERVEIECEGFAEVPIRRVWSRKDDGKHLSFSDDKFVLSNAAHADHGLYCCVLISSVATTSRDVQLIVDETAPQCATKVRVQCEGRQRFAAHWVPGYSGRNHSQTFRIFYRKMREGLNDEAKEEWEVTALTDQPKIHLDRLELFGEYEFKLEASNRFGAINCTVPGTHYTCAKLDPPSNFFLGQATTFNMERVPILNWDKVKEANLYKIKYRKSCDGNKGNGLLQEIIQTSETNYKLPADKFNSTPKCCFEFVVQSIRVPFTGSDHSPAIIYPSSCADGILPSNSATVLLLSACGLLLLFLIVIFALIFCLQRFAQKIQPRHNRPNIGKSSKLRHNRLNHRKADSKNGEIGTQSEEKSCFEDSFNCSSSRFGSTSTAASVYAQCAFGHPIAITRKLFPENYICTKFARFDEEEEEEESDKSEEGFGHISSDDVAFLNAFNGFATNSGIINDRNDSVSGNNESDWQFADNLNNAERKTATYVEMNMADGEGEEKRSVVGEMLREKYLFAEAELNVLQELRIEQLRREINVKEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3U6</accession>
    <name>A0A914H3U6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3U6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13005.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13005.t1"/>
        <property type="gene ID" value="Gr19_v10_g13005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="62"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13005.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23868" checksum="8FE3974AFE677C91" modified="2023-02-22" version="1">MSDLPRDDGDIWCRKEKKKTGDDNKAILDEIRSGQITPPSLFAADEAGFDELEALSTKRGDFNVELLRKLHVIALTREGQAPSYAGLLRGESGESPSGTIKIGSSYVAPINSKVPGLMQEFVAWLNGEEASRDGVIRYVAEAHIRLAALHPYGNGNGRSSRALEHNEYNKALKSAIVDGQPNQFYDMMSTWIQNYSGLFDAERGDSGQANRRLSAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3W2</accession>
    <name>A0A914H3W2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3W2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13408.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13408.t1"/>
        <property type="gene ID" value="Gr19_v10_g13408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13408.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20765" checksum="EE5D4C612F372C7B" modified="2023-02-22" version="1">MAHEKTCGVIGEIIGARREGRAATIIDARREGRAATIIDARREGRAATIGGYRRKRPLPFPPKLLNGCRSAGAQTGLDCGDGRSSRGRGARGRAGRRSAVDGGHLWGSDEADCAAIPGKTFVGHCPGGENTSPRWETHLLAAIFARIWLRIADENAVLTVARFAATDDQKEKKGQTDELWEGSKRIIFCKVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4W9</accession>
    <name>A0A914H4W9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4W9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14016.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14016.t1"/>
        <property type="gene ID" value="Gr19_v10_g14016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF29">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14016.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35564" checksum="57E82A6EFD6121DA" modified="2023-02-22" version="1">MHLKTAWTCAWKPFVYLRLIGALIPPCVVLWISIERFLAVFASATYRKNISPNSHLPLIAILSYTVVAVIIAYTLSWYHRTIPVDAYCGRKNAFTRNYTTFVYLADFFGFFIALVINCVTLCGLGRLYTQREHRFEVKRQLKRINYLLIISLVSTLTVAIPNGISLTSAWFHRLNIALSDPANWMIAAKCSVNLFVYLLLKAGYRQRVYEILGCLSNDQRLSRQFGAGLSQHCASGPVIETLQQQQQLKRDSIVDLAKMIACKQTQRRSTRKICGGQMLNVTNLVTDGRGILPSERRENARKAWALSRHVIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H519</accession>
    <name>A0A914H519_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine-rich protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H519"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14054.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14054.t1"/>
        <property type="gene ID" value="Gr19_v10_g14054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038032792" evidence="1">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14054.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="12570" checksum="B7E4CF90EAF4D3E5" modified="2023-02-22" version="1">MNSLKMFIVLLTIGIVLVLASSVPIDEGESVSLIRQKRGRAYGSGGYGGNGGGGGYGGGGGYGGGGNGGGGNGGGGNVGGGDWSGGMVVRQRRGGYGGYGGGGGGDDERVSLIRERRGGYGGYGGGGGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5B9</accession>
    <name>A0A914H5B9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5B9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13964.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13964.t1"/>
        <property type="gene ID" value="Gr19_v10_g13964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13964.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11561" checksum="C529DDED820C4056" modified="2023-02-22" version="1">MVELSNRLKQLCDRFPTCVLRGGGVGPIANRLVCGEKKLGLREVRSEGQAVRRESGRDDRSLTRPAGSRSEVGRDYHSVSSFPQIRQHPYHRGGGRAKFQPSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5J3</accession>
    <name>A0A914H5J3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose mutarotase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5J3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13419.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13419.t1"/>
        <property type="gene ID" value="Gr19_v10_g13419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF49">
        <property type="entry name" value="ALDOSE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13419.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23880" checksum="332DF8B03EB1240F" modified="2023-02-22" version="1">MEVANVSPFENPWGSGMCQLSRIPGGQECVNFRESLEDIEATSDLPCPVNVVQHNYFNLAGHGDIRDHSLKLKADRFTPTSPDQIPTGEILTVSGTELDFREEKKLQNIGGQPIELDHNFVLNNGTETDGEPAAVLKAPDNSLTLTLRTNQPGLQVYTSKSLSLPVLGLRGQHYAKFGAICLEDQNFPDAVNHRNFPNSILRPGETYKHWAEIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5W0</accession>
    <name>A0A914H5W0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5W0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14115.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14115.t1"/>
        <property type="gene ID" value="Gr19_v10_g14115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036862476" evidence="1">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14115.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14913" checksum="B768E66835B81E2D" modified="2023-02-22" version="1">MAVVFFILMISSATLEAQRNENDKFFDLMTAIGEDFGGEFHEAEKALELDLNATNSFLERLHKFAIRELVTKVKNGEFACKEATENSAFKEAIKTILGQNMRNLLKAIVVPKQSKTMIDKNRNQAFLIIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H681</accession>
    <name>A0A914H681_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H681"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14377.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14377.t1"/>
        <property type="gene ID" value="Gr19_v10_g14377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="80"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14377.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26962" checksum="2C975CF3D7D6DC73" modified="2023-02-22" version="1">MGDPLGCGFAFDPPIRTPTHQAAQLWLNSSSTFRGWPKVSEKDYQEVLRPHHSILCKHQPSSLIMLAIRLSDDIDVVRTDHCGFLQCRTDIIFLGPTPQNRWDSAACHKDLALSEPDQLIVQQNGENYEFRSVRAERPIPKGNSGIFYYEVTIVKREDFVSIGLATKQKPLKDEWVGRYEGTYAYQSDGTFWGHAVKGCSRSNGRPHIEGKLSFGVGDVIGCGVNLATRQILHKKWTAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H690</accession>
    <name>A0A914H690_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H690"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14567.t3">
        <property type="protein sequence ID" value="Gr19_v10_g14567.t3"/>
        <property type="gene ID" value="Gr19_v10_g14567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14567.t3"/>
        </source>
    </evidence>
    <sequence length="254" mass="28728" checksum="40E071C43A30D96A" modified="2023-02-22" version="1">MVGKESTFLLSQLYNKHWRELNPLDTKISVCGAVDPPTTKSKARYGNLALYKLNEYGILNRTIVTACLVCRFANLFEHNSRFSFKFEKISSKSSKTADPSDLDGQIQQKQLPNNSDAHQRTLQFSLLWATFWAIITITKYTVCFHPKSGQHRTIWPTISVGNQIQTSLLHPIQGIFTIRHIICAANDAYYLSNPRLLFSAASLKRQSEPNLIIIRSIDIEQFGPTETDRKEAEKSDRNIIALATRRGAGFGGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6N3</accession>
    <name>A0A914H6N3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914H6N3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14184.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14184.t1"/>
        <property type="gene ID" value="Gr19_v10_g14184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF22">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14184.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="49455" checksum="9CE425611934E5FD" modified="2023-02-22" version="1">MDDMECMVVKNGIIVKRMASKKEYIQSLHLCSLELYILTCTLDGLQKDSVLLEDAAQRNMYSLILPETNRRHRHSVKITLNPIRPSYQERGLVLCMSRVLLYEKWQLLITGLEAYRLFKVDLVVTHVQSALLSIFELLKAYEQLGFLKIMPGIRLPHQRGMRWDPNAETEFNGQILLAHECFYEYRESAQFIGLIDWDDLLVPSKHFSTLPAAFAAAFTQNPDTAYFLVNKLEASFVEQRVKYPAEFSLRKLLKDGIRTAEMYNDEKMVVRPKALRGFWMHNSQNVEPNKRAVKVFTNYSIILHLANEERANPDEFQTPFMTKFNISKMDLHASEQLKKLNNSKLPSSQPFYNALVKCHSQIFAYYKDVGPERSGCLSYSLCVLPRLPEAICAVTKSKFDTVLTRSGAVFHARKYSEFGHERCIKEGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6Y9</accession>
    <name>A0A914H6Y9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6Y9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14762.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14762.t1"/>
        <property type="gene ID" value="Gr19_v10_g14762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14762.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22839" checksum="E123B0A0CDB1EA4C" modified="2023-02-22" version="1">MLHHRTGWSTTTNELVLWFVFGLNWSAAQIGRFFAFYFAAEQCAIILAVTVIIPKLQGVAPWPLPSDQPFLSVLIAGTALLLLAFATLVGTNRLFRKRVPSGQNVFSRCYGTIKTALHNKKRYKQRRLVLAKSRNQQISPPKNVLDHFLDDHNCERDKECDFGRKNVCGQSMTLVLDPTQNQAEAAEQLREGWRKEDKNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H848</accession>
    <name>A0A914H848_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H848"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14910.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14910.t1"/>
        <property type="gene ID" value="Gr19_v10_g14910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14910.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32695" checksum="C8F2145FA24D20C2" modified="2023-02-22" version="1">MATSVDPLYMDKGFVPVIIASSGIVAMICCVGIGLNSCLVYVTIKTKSLHSPCKILVALYAFFASFLLFGNCVKFVIFVFGFNYITLRTCFYIQIVPLMGSAITLTLQLSIGIDRLIGVIFPFWYKASGKYLTFKFIIGICCIRHWEKPVICLLGDPSQQPENQNFTNITVFILYCGEFLCYTLILLIMRRRRSSIPENVKKLTISLSVLMSIGLICFILNTIFTNIIMPLLNFDASTIEYFVKPICLALQSMAYGSSAPVLYFCNAQYRRAFRTQFGHQANQVAAIQPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8C8</accession>
    <name>A0A914H8C8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8C8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1475.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1475.t1"/>
        <property type="gene ID" value="Gr19_v10_g1475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1475.t1"/>
        </source>
    </evidence>
    <sequence length="768" mass="89192" checksum="CC7B9925F6D7695C" modified="2023-02-22" version="1">MPPKRQNEQFVEESQKQTFGDSSKDNNNGARKFKQEKPDNDVIILNDDDDDDRKPLLEKPALTKRGRKPRWDKHQQEQEELPPKKIRANESDGDEKSQTSVFDYPTIFWKLARPKYGTFTFMCKDCQTANFQLGDRRFMLTPQNGDGRLEFTQTFCRDCAKLNFDCTDLIMKHQKKDAPTKNGHYHPYTGGNNTPGFVGNKTNKFKVHLPKKLVFEGPGWMVGMSGIIYPNSWATVGTLEKQYVIVHLRDGRKYRFKVPRGSFLSPQQLERGIHHGMIAEMERLMTRKRAAFQEDEEEEGELVDVQVVEEEEGGLTGLQVAKEERKESVEAPLLPMSQTKFASEQAAERTRQPPLANVRPPEQRGAVRERELVPPNETERLAQEKENERKRKAQKWIEDGRKETERRRQEALRKETERLQRMTNATKEGATSKKKEEEKLGTPKQAPQQAVNEMLEKQKEEERLPKQKEDPGKKEEDRLAKQKEETEKKEEESSAKQPEDVGNRPNNGIERAVNPAGEEERIRRDQERKFKLRELELLKELKPYRGGWMRLVQGKDPTPDVHYLHEKDEYHFSNAVDKYRIHHPELAWDLPEFNPSAQIQRNIAEFKGLFEREVYDENYGSKTREEKEELIALVKGFRFYYMEDIGRFMLKIFDNKISHITLTDQLAYVLGYEQEQQILNEDLAKYSVDLGGGVSHLCIYLNSGIIESMIFGNTFANLLQVIAVEGKSGSVVEKDFQSPLFHKIIAREVDVLDVEIRTLTGRYVYAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA45</accession>
    <name>A0A914HA45_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CWC25-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HA45"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15194.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15194.t1"/>
        <property type="gene ID" value="Gr19_v10_g15194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15194.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="38026" checksum="6FF4720C436FD304" modified="2023-02-22" version="1">MSNTTSASDDKKLQWMYEGTRSMVNREDYLLGKKIDKNFEMFSDVVVRDQEEEKRETFFQQSLLQPSTSVAQHKVSALETRIVRTEDPLVALKFQEEQRKRQILENPLLKLKAQRVLRKAFEKELKKAAKKSKEHKRRRSNSSSDDEVKEQKKRRGESSTKESEHGRGRRSNSRKEKRRSSNSRTTRDRSREAVGSSRSDSKRGKDASSSAGASISKSKVSESMKAAPTARLTAPPSKKLTAEELEKRRRAMLANASWRDEMRERNIREAAEKLGKERDEMSTNRCSGFMRPMMHNATEGSTIEQRLQSNRMNIQRQHDHMDKSFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA48</accession>
    <name>A0A914HA48_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HA48"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15193.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15193.t1"/>
        <property type="gene ID" value="Gr19_v10_g15193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15193.t1"/>
        </source>
    </evidence>
    <sequence length="868" mass="95571" checksum="FDBF2A247A8FA7FD" modified="2023-02-22" version="1">MDELVQILEKTVSQNSHDQQVALKLLNDASQHNFAEFVRQLAIVLSNTENNPFIRKAAGLQLKNTLVARDQAVSDQNKTRWLSMTTEVRTAVKSCVFQTLGTETRPSTAAQCIAAIACIELPANQWPELIEQLSVNVTADGTNNPILREASLEALGYICQDLPELQRAGPILTAIVHGMRDEETSNYVRLAATTALLNSLEFAKHNFENENERNIIMQVTCNATQSSDRNVRVAALQCLVRIMSLYYRHMEPYMGRALFQITLQAMKDAEDEVALQGIEFWSNVCDEELNLAAEVEEAQEQGITPEQVSRHYALGALQHILPTLTEKLAKQESDSESEDWNPAKSAGVCVMLLAQCCGDTIIDPILPFIQQHFTNPDWHYREAAIMAFGSILEGPTKLKLLTLVEQAIQPLIVTLSDSHPAVKDTAAWAIGRVCDTCEALVTREQTLATLLPSLFTALQDQPRVATNVCWAISSLVKAAYQVAVDSGIGSVDEKGTPQTFILSSVYPNMVQELIKTSDRTDSNANNLRIAAYEALMELIKNSPADCYPVVQQTTMVILGKLESLLSIEDALVSSNERSQLRDLQSQLCATLQSVLHKIKAEDAPLISDAIMAGLLRIMGRCSGKESGAVIEEALMAITALIEVLKAEFQKYIVEFKPYLLNALNNHEDSQANISTVMDEIMEKLLGILQDPNVKRTVKSQVLNAFGDVALALNAQYSRYLGMNMKWLTDAIAAAQITNPEDYDQVEYVESLRESCCYAFSGIVQAMNGTEEGLQQIQHSIQPMLQLIVLIANSQPSAPESLCASACALAGDLLHAFGVQFLPVVDTPDFGIATLVTKCKKSRQNKAKSIAIWVGRELSRVRRQAAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAI8</accession>
    <name>A0A914HAI8_GLORO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAI8"/>
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        <property type="protein sequence ID" value="Gr19_v10_g1479.t1"/>
        <property type="gene ID" value="Gr19_v10_g1479"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1479.t1"/>
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    </evidence>
    <sequence length="72" mass="7519" checksum="57A6CB9D02E7E8DA" modified="2023-02-22" version="1">MPFSLPRGKITVVRPAAATFAKVPPMAEMAPFAPMVPLIAMPQGTGCPIPSKTRAAKTESPPEGPVLETEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAQ0</accession>
    <name>A0A914HAQ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAQ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1536.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1536.t1"/>
        <property type="gene ID" value="Gr19_v10_g1536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
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            <begin position="308"/>
            <end position="458"/>
        </location>
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            <begin position="224"/>
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        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
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            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1536.t1"/>
        </source>
    </evidence>
    <sequence length="458" mass="51260" checksum="B93A296A3C9BBC02" modified="2023-02-22" version="1">MVRTYTFNPSTQSSLSTSLPALPPAAVFAHSASIRRRAAPAPPPQLLPHHPTAFPATRHRRDLPPPDPQSHNRNASNISSSSGIGESSFSPTAASSSEHRQVVVEEERTTFIGIRSVLINGQRFFQPVSVPAMPSSSVPVEAVAPLLALSTVTNNGQNYQQKSQKFVVPPPGEGNSPWIRGNPQPKNGEQRDSHTWQQAFEAKTKAHFGATFGRESTGGWIETAKAAEQERHRMELLAQVEENRQQRIRERQRDWQMEERERIKDELYQQRMQMELEEERRREREKALLVELKMAKLAAAQRATEETLRAAKNGENPRGKGAPRGQPMPSDLFDSNGTATKQRQRSLENRTPEGRDQLEWWERKDRRKEMEKANGRGERPVQSPVIPAFSGGARGRRAASGDSRRSGESAGGRGHIRRPNGGNGGQTAHEPSTARRQRTLDTDSGRHIARRYNTDQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBC7</accession>
    <name>A0A914HBC7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBC7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15782.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15782.t1"/>
        <property type="gene ID" value="Gr19_v10_g15782"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15782.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14139" checksum="4B3F2A7E567459CA" modified="2023-02-22" version="1">MTTQFDLIVTPKLLLEHNVAKNYKLEHVAQPDTRNVVYLVYSTHQSLAMLMRNWLHHLPDDDLRLHHLREDQRVWNRLQSVHSLPLHWFPTEQPKLITMELPQLMCYCCQTAGTADDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBI1</accession>
    <name>A0A914HBI1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g15549.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15549.t2"/>
        <property type="gene ID" value="Gr19_v10_g15549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001900">
        <property type="entry name" value="Myotactin form B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF11">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ETA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="4037"/>
            <end position="4062"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="179"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="496"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="990"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1296"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1388"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1493"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1738"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1834"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1939"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2035"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2141"/>
            <end position="2236"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2241"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2349"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2444"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2551"/>
            <end position="2644"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2645"/>
            <end position="2742"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2747"/>
            <end position="2840"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2844"/>
            <end position="2948"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2953"/>
            <end position="3053"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="3058"/>
            <end position="3156"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="3269"/>
            <end position="3364"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="3367"/>
            <end position="3476"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="3482"/>
            <end position="3579"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="3590"/>
            <end position="3691"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="3692"/>
            <end position="3791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1696"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1915"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2532"/>
            <end position="2553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4366"/>
            <end position="4406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4425"/>
            <end position="4445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1707"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1915"/>
            <end position="1925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15549.t2"/>
        </source>
    </evidence>
    <sequence length="4542" mass="506479" checksum="32EFD4381D23DE22" modified="2023-02-22" version="1">[encoded data, 4542 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCL5</accession>
    <name>A0A914HCL5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCL5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16119.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16119.t2"/>
        <property type="gene ID" value="Gr19_v10_g16119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16119.t2"/>
        </source>
    </evidence>
    <sequence length="205" mass="22789" checksum="C3317B99D261CB76" modified="2023-02-22" version="1">MFSTGGVPPSSAPPFGTADWWASVAAILHGNTSTSTAVGSVQNCINNRVMVSHNIIHRLSMHHQQQQHYQFQRQQQSVVHLQQHAQQKQQHQHQQRAGGVGAVVAVAQQHSSSSNIMRNHTITSNSLNIMSNSVWDPNIGGTVPAAAMTNFASGVSTECCGVEVVIRRLCRRMKLVMISRFHRVNFLFDYRVQFVFSFCCSTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCT0</accession>
    <name>A0A914HCT0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCT0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16170.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16170.t1"/>
        <property type="gene ID" value="Gr19_v10_g16170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16170.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13557" checksum="88C69627ED8A4BDF" modified="2023-02-22" version="1">MPPPEKKCKRQSATIFICAEVLLNIFRCLGHAELGLKIALISCRFNALVDKHFGDNRKWTLGWLEIRSSEDGTDAAELFKKNEYGNFIQLPFPQRASPDNIIGFERIFINTFSRRTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCV7</accession>
    <name>A0A914HCV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15875.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15875.t1"/>
        <property type="gene ID" value="Gr19_v10_g15875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15875.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24079" checksum="8B597601D8AA13AB" modified="2023-02-22" version="1">MCSHGNGHGGPCSSVVESFEQHQEGTQYTMERFINKDRIVVLNESIDGCGKKVFKRWDERMDKEHFVESDVDEELLFSVPFTANVKLNGICFIGKMDGSFPARVRIFKDRVNMSFDEAESAKPEQEMELKQDNAGLIDYPLTANKFNSVGHLTLHFPANFGDDKTCIYYIGLRGNFHSEFRERIVIATYEARPMADDHKAELKDPVNNQIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCW4</accession>
    <name>A0A914HCW4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCW4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15953.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15953.t1"/>
        <property type="gene ID" value="Gr19_v10_g15953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="241"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15953.t1"/>
        </source>
    </evidence>
    <sequence length="604" mass="68659" checksum="5F1E4B9012369471" modified="2023-02-22" version="1">MCGNHSTHAGIPRPSIRPRIDIARRAEMERIFPTGHNFRTRTNRSLQGKFQLKYANKNELVLEWRKRMARTFVGTYWQDEFLQWDPDTYDGATEIFLASTDIWIPEFSLYYSVNFNDAVKLQSNNDVRVNYTGHVRYWIPFSTESLCSSVDVKFFPFDIQRCTLLLGSWAHSNDSIKYSLYSKNLSLIDFYDNQEWQLDLAQSHITSDGFLYDYLDPPLFWEMIVIDLVVARQSFYYVFNLVIPSAIITLVAVIGFHTPSTSGKMRDAKFQLGIMTLMSMSMILLAIVEDMPKFSISSSRKGRGSFSGIPLIGLYYFMLLAIVGMSTVTTSVRWGFALLGTFPRKRRIGFRYSFRFSKTKRARAAPQQQQHNASGDGAGEMDTLLSSPPAPGGRNGNRMGMCGHLNGFAGIGGSDSNLFGSSSPTLSEQQQKGGAQRAARSLLRLIAHNGRGRSSGSDSRSLIRGKAPREQKESSADRPFPLPSPLLRKRHSLLYQENLLFYQCFQQLIEEITFGLGRMERTVQSIRQDMASMVPQNDMESDWQKAIRRLELLSLVFYVSLLSTTMWLFFYHDWYCSIGHNPCGQQNLKCPWLASDPTSPSCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDA5</accession>
    <name>A0A914HDA5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDA5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16446.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16446.t1"/>
        <property type="gene ID" value="Gr19_v10_g16446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16446.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25061" checksum="75415C16FF04F7D6" modified="2023-02-22" version="1">MITSSPNTQRPTTNGRPAGKKKCLAVLQLDKLTVCLKYEFFMTETEQFFASGDEHCEPTVSHMMQTLLPKHFAMSMEELTEKFDLQLQHLDIEFVPPEFIDIDPREWCAELVKDRGKYKVLLQPKLDNNSASRIVDARKNVPENVGVSGRRLDDGPVSGQRNANREGGRCLEDEDVPMEMVDRKCLILAEAANVRKWGMKFLHIMAAKVGPQMSGHGLTKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDB3</accession>
    <name>A0A914HDB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SANT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N-CoR nuclear receptor corepressors family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15575.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15575.t1"/>
        <property type="gene ID" value="Gr19_v10_g15575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="445"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="997"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15575.t1"/>
        </source>
    </evidence>
    <sequence length="1187" mass="132552" checksum="DDEAFAE8BB9D2305" modified="2023-02-22" version="1">MQQTPNNNANRQTAGFPSPRLDEQTLMALQQMGLFPQLFQNTPSTSGLGLDMTAQNNDFLRELLKAQMQMASFEGGLHNQQTKTPKELSRRRPSLMHDSGTSVIGHNDVLRPSQLLPASDNKKMLHHQLSLSTDTNFIGQTSLPDSQEEEDEKQKRMLSERLDKIERERIQATNAQKNAQKKMRACDAVLRQEPLMLAEEGKGSVADSDEEEADELSPADALVERIYAENRRKTSDMPTNMSSTGALGVPMANSNNARLMAEDAARLEEEFERGVLLLPTLVQAMRIQRERRQDALENRRIIYEEQLTLWERKVAVYERSPKKMAKDLRHRELFEKTFVELRKLREEKERNTRVERSRFSLAQGGNGIPIAPSETLLHFVSNNNNSRSELPASEQGDNDGESVHEKAFAAAIVPPTYVTKPRRFFDNRNSIVDNPLADACAQFETLQNQWTDLEKEVFMEKIAIYGKNFAAIAAFLPSKNVKECVQFYYMTKKRNNYKQKIGRRRKKIGRQGYQPPVMPRFGDSDENVQLRNYGREGTYVECLLCSARILVLESLSQQSPHEQPFDHHFGLALVSSPSQQQLQQQIPICSNCQKQELRNRQLNRCPLGSCACVGGKRKMRPVRNVPEKFASLGIERKRFLISRLKIPPSTNKCCTNCFKRITKDIDGLLVGELETELEEFNNRAMVHTGNAKVEPCLISGKIDEETENIVETKSELGEEMCTTGMEGPPVKEMKLEMKQEEDEFEEGLLDEVVVKTVPMETEANVVTEDPLRPRFGSLTKGTPNRRHRSTLLGTWGGPSFRTAENRQMTEEFPLVPNFAKAFSEQQNAMIGPQATVEEAASNVLSQFNIMLATGTSSSHEKLHDQTVGGMLSSQTAEIVRAKLAQREREKVRPTTLAKADKDNNVAAAAEFVRKSGEHQRHDGMRRKSGLANALLPSPLPDALAVSSSRLTASHRTVSPACAPTPKLAEPLPPPFDDDATKNINDLFVGRPMLSTMTQSPSCYESLSEESDTEKGGEETTMAATKKNSAGLMCSTSAAVAAPLNFFSLLDLMDETDNDQPQQQQQQQQRRTTTGEPCAATGDDASPASAFAAVAALRNQQQLSILATAAAAQWGDVGARKTDKFGAERGEEECVYEPLNKTHKKKNPRKAVLILESVRLLRSFGSLSFLCRLSSPGEYGKGKEKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDZ1</accession>
    <name>A0A914HDZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16476.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16476.t1"/>
        <property type="gene ID" value="Gr19_v10_g16476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16476.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17465" checksum="FB5BF959E2498180" modified="2023-02-22" version="1">MRRSPNVSACKSSWCAVYAEDKRRCIPNGGRQTIRGCRNEVRNLRAVIQGLQHRNVQLMRQNTELHRRLDQQRQCLVRVEQAPPNANDKEITPRGCPLVKFAAKSERARQKIVQKIEENIVDGIRVARHAYQLGKKCGFVQRSASYRINESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEE3</accession>
    <name>A0A914HEE3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-gulonolactone oxidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEE3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16748.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16748.t1"/>
        <property type="gene ID" value="Gr19_v10_g16748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038001292" evidence="6">
        <location>
            <begin position="24"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="61"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16748.t1"/>
        </source>
    </evidence>
    <sequence length="629" mass="70600" checksum="3C939BDAC49DF105" modified="2023-02-22" version="1">MEKLLSFLLLCFTVLAFTDVINSECPTVKGFVGECFDREDANDRNYEKWCYQYASTSMNYTRMRPKLILVATSVKDVQAAVNYAREKRVNIAVRSGGHQYSGASSASGNNIQLDLSEAFKDPDVDFKVDQKAGTVRVGVSFTLWNLYSMLSKEGLYIPGGLCSNVHVGGHVQTGGYGVSIRAFGLFADYVTGLDMVTADGKALHVQPDSQNKTIRDLFYAVLGGSPGNFGAIFAAFGDIRKMIFDQKERMYTKQSVLNILHFVTQTAELDRDYDIMVTVLSGNNSFPGLVKVPSVINVAAQWSNIGGQRQPVDDDVTGFFKRIEAAFEDTFAIPMKDQDIDWTVHTPLSNMSLRYAFPGVREYFMPYEKRLYLSNWNTATLQKRLWSNWTADRLDEFLTARNKVSKQLFSQSSRQQIDKLIYKQPAPTDVGRFEIFSQLQNCGGSKSQFYRNSLRKNPVDGRDLVSYSWRNMTVGASFDAFYNTTEDPGAQQFVDQWQEDTLRGALGPRGHFTDLPPDEAYKLFWETYGDRNMGNVWQQYHPKPQYDRLVGIKRAVDPTPVFTPNNFTVGVPKGKPDFASPKPVLLPEEVFPITIDLISTSGAGAVDAYMLGWMQAKKDRASKLASSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGU7</accession>
    <name>A0A914HGU7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16495.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16495.t1"/>
        <property type="gene ID" value="Gr19_v10_g16495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16495.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8157" checksum="B6725104C8987769" modified="2023-02-22" version="1">MSVLISRYCRITKQVLRKFHKAPFEIEPLPQFIDERNRLFDDLMAVHKVEFGKKSSRTNYGDTAGRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHQ3</accession>
    <name>A0A914HHQ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHQ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1747.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1747.t1"/>
        <property type="gene ID" value="Gr19_v10_g1747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1747.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="10046" checksum="B87B038B032BA90C" modified="2023-02-22" version="1">MCRAWYPQWKCKVQFKLIKLATKLICKEIFLRLFKSGFSFLFPFRKPKFRIEQEQEQEQNRNRTGTEQAKLEQENTGRDPNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHQ5</accession>
    <name>A0A914HHQ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1727.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1727.t1"/>
        <property type="gene ID" value="Gr19_v10_g1727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1727.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7778" checksum="86583CA9458BCADD" modified="2023-02-22" version="1">MNHHYHHYIAIFMLFCLVVQSQFSSINGLPILQRDRVKRGLGDYARIAASGAVSAVAWHATNKAINKIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHT0</accession>
    <name>A0A914HHT0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHT0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16753.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16753.t1"/>
        <property type="gene ID" value="Gr19_v10_g16753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16753.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12945" checksum="663CFC7A0DB6F4BD" modified="2023-02-22" version="1">MGLPESTDPLPSKRAAADKAQRQALTAWRTKNNTIRSSASQLKNIQIRESLTREQMEERRRLHALCTGKRTKDGQDWIVYAGSVILRSEVHIFRQQMQTQSIPPSTPNTLSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ33</accession>
    <name>A0A914HJ33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g193.t1">
        <property type="protein sequence ID" value="Gr19_v10_g193.t1"/>
        <property type="gene ID" value="Gr19_v10_g193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g193.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28957" checksum="DFD4276BFCFA30BE" modified="2023-02-22" version="1">MAHKRKRQNKDLPCSSTNADADQCPFPLEQLPLNTLVIVASQLPFKDFKNVGMISKQFNRAQRITRFNRKRVSVDMLRKLFPDEVPDSKMDGTERSIGMLEMMNPMRQHLRSSPPRNIREVDLSEFSSFRESHFVELFRSISNGRDLFSDVRRLNVQKCVMELRDMDFLAQLMPKVWYIRCSAQSLVIPQETEQQQMALNAEQMRQLRAKLENFDVVSRQCTKKHLWFITKLIEMFAELEVIQLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK33</accession>
    <name>A0A914HK33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HK33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2205.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2205.t1"/>
        <property type="gene ID" value="Gr19_v10_g2205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2205.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="39977" checksum="7733AEBDAE0C50FC" modified="2023-02-22" version="1">MTTSDIKSKQYLLSMAIMAIYVGCTASLPQVVNLAIAKKLVSDLNLRTNGLWTPVLNRRFASMNINEKRRMTGLRGVKPPPPVPVHANLGTTRRHRLGATCTNRVAFDVRTQWPSCADIVNKVHDQTTCASCWAVSTASAFTDRYCIERAKRGQSTSASTPNNHFSSLDVLSCSPNSYGCNGGFPDQAWRWIKYNGVTSGTDYTTSSGCKPYPFPPHSNKNYNTPACASSCTNSRWSSNYSADKKYATWVGSLYGNGIVASIQNELRHNGTVVAAMDIYDDFFYYSTGVYRRVSNNYIGGHAIRLIGWGTRTCTDGTSQDYWLAVNSWNTNWGQQGVFQIARGTNDCRIETMGIYFGTPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKL1</accession>
    <name>A0A914HKL1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKL1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2339.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2339.t1"/>
        <property type="gene ID" value="Gr19_v10_g2339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2339.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14166" checksum="5726034C9B78D3D6" modified="2023-02-22" version="1">MSSLSFQTIPKEQCQKDLFKKVQEFENSALGGEADPARGIKANNMVTTSFNDRISDQSDQHALPFVLSRRGKRADNQQPAGCIALGLSAFVAAVIGGLEVAKVLPGGVIAIAICFGIAVLSLILMICACNWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKT7</accession>
    <name>A0A914HKT7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HKT7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17547.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17547.t1"/>
        <property type="gene ID" value="Gr19_v10_g17547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23070">
        <property type="entry name" value="PDZ_SNX27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000061">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="163"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17547.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54700" checksum="0751E8AA071F3965" modified="2023-02-22" version="1">MFWHEKSEVNKKREKEGKAKYNVLSSLNGLASTACENGPHLISIVKSESGFGFNVKGQISEGGQLRSINGQLYAPLQHVSAVLVGGAADKVGLRRGDRILEVNDVNVEGANHRQVVELIKAGGDRLRLLVISASLDNCEVGDSTLSCEDPYFGGGGYDYSEKRSLPISVPIHQMVNSNGEQFVAYSIHMAGRHLGSRRYSEFLQLNKLLKEEFPDFPLPKLPRKSLFRLSGQQLDSRRRMLEQYLEKVCAVKVIAESDTVQEFLMEDFGSKSTPIVDVSLRIIVCGNTLTLNIKRHSDTREVFKRVCEELKLGVEAASFCALFEVIEDSFTRKLHDRECPHNIYIQNYSSAAATSCLSLRKFCFDVEKEKELCEEDKLFRSICFHQAVEDVNNGIIKAGERLYQLKALQRDDRCIQYLEMARRLDGYSSVVFPQCQFEVPDSDEGGTATMSIGFHSVVLKVRQEDKQKVRTISLEWSNVVAYSSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL58</accession>
    <name>A0A914HL58_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL58"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2506.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2506.t1"/>
        <property type="gene ID" value="Gr19_v10_g2506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036675082" evidence="1">
        <location>
            <begin position="28"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2506.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24824" checksum="C7997AFD3CDED690" modified="2023-02-22" version="1">MAFSRPIFTILLPIALFAAAQIYSANGAPSAAAAAAGADQSRKAFMDLLKMFDGQLKFPCLKKDEKILAQKSAIKEALKKLSKNITNEDVTNLLTQIGRLADQMGAQAKDTVAGMEPYSFKVQLGNEPQTVAYYELMFDAELKKVEGCFAREKSNELQNVLKRANPDLFESIYKQFLSIATFTFLINELKSNKEDFFQRYFSTDGGQTYELKKSYGQMISEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL60</accession>
    <name>A0A914HL60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2342.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2342.t1"/>
        <property type="gene ID" value="Gr19_v10_g2342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2342.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9538" checksum="BB5AAEC6D47AC308" modified="2023-02-22" version="1">MTDPPQDISPYLDITAVDQKIFSGRNHTTHAKLGDVENVLIQYQQHHHQQHQQQQSESMLGDERRIDGVRHVLTAQGWQRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLK1</accession>
    <name>A0A914HLK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17752.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17752.t1"/>
        <property type="gene ID" value="Gr19_v10_g17752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17752.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10795" checksum="ED22D9F796B9B382" modified="2023-02-22" version="1">MSLDQYFVMYCGDAYIYSSNGICHHVAVRCASFGVGDVVGCGVNLATRQLIYTKNGKRLETTGLFVSAAELFPFVSLGLVGTKIEANFGPNFNFKIAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNX5</accession>
    <name>A0A914HNX5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein Rab-13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HNX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g288.t1">
        <property type="protein sequence ID" value="Gr19_v10_g288.t1"/>
        <property type="gene ID" value="Gr19_v10_g288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g288.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25518" checksum="DC38FD0E55DA1FDE" modified="2023-02-22" version="1">MVNIRIDWLKKRHSVLNVFVADQSFIHSLAVAAVLLLIGDSGVGKTCILYRFSDDAFNTSFISTIGIDFKIKTIELRGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMMVYDITNAKSFDNIAKWLRYIDEHASEDVVKMLLGNKCDMSDRRVVSKERGEKIAIDHGIRFLETSAKANINIEKAFYDLAEAILDKMPDRNSVGPGPNIKPLAGGADRSMKSNCCYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPR0</accession>
    <name>A0A914HPR0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPR0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2759.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2759.t1"/>
        <property type="gene ID" value="Gr19_v10_g2759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2759.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11573" checksum="B9994E86EFCD87EF" modified="2023-02-22" version="1">MRIAQFLGCKVGGEEAERVAMNLLRFGGAELYRPWATTEQKEQRQIDPRKLNVVGGGICCRWSGHTFGQNVCDSPVIKTLASTEAQATRSQSAPPAIIAQFSLHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPT4</accession>
    <name>A0A914HPT4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">F-ATPase delta subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HPT4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g332.t1">
        <property type="protein sequence ID" value="Gr19_v10_g332.t1"/>
        <property type="gene ID" value="Gr19_v10_g332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="13">
        <location>
            <begin position="46"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g332.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19324" checksum="7D2778E15CB7B1B6" modified="2023-02-22" version="1">MKPPQLVERIYINRLLSSIVALCFRERTFAEMAAQPNTSPPSSTELKFTFASPIKAIYANAMVKQVDVPGMSCSMGILPIHVPTLAVLKPGIVKVYELDGNVSKFFVSSGTLSMNIDGSCQVLAEELCSVADLDEQAIKTLMDNSQKTATDLGSNDVEKAEAGISIDVAEAALRAIAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRH7</accession>
    <name>A0A914HRH7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRH7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3982.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3982.t1"/>
        <property type="gene ID" value="Gr19_v10_g3982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036973839" evidence="2">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3982.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11584" checksum="5A91542F708F1798" modified="2023-02-22" version="1">MEGFWIIILVSFFATNSLDKAESVKLELKTFDEIFGEGWWDKGEAAEDLKMPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQNPSLTKSYNSDNAKRNYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRT7</accession>
    <name>A0A914HRT7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HRT7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g314.t1">
        <property type="protein sequence ID" value="Gr19_v10_g314.t1"/>
        <property type="gene ID" value="Gr19_v10_g314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16475">
        <property type="entry name" value="RING-H2_RNF121-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407:SF0">
        <property type="entry name" value="FI05221P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="RNF121 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="205"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g314.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="38069" checksum="8B279E8F54D1B3E0" modified="2023-02-22" version="1">MSMLDDEEEIRWRREHEELHRKHRGHDAMHAEMFIIFIVSMVMAQVILMLWKRKHFRSYQVATLLGLWLIPFMVSVQNGWWRFILSWTVFTSSIFYVWRRVNQPTISGSTPRFVYKYFLFLHKLSYIFGVVGYFSLIFTVMGINALFGIRSNSSLDFGVHLLFYGLYYGVLGRDLAHSLTDRLACKIGYFTHDGLPKRVLESDVCAVCGNNLHKPSSNQDNFNPLDEAQGGVMTEAVEVPEEKTYTLACNHVFHEFCIRGWCMVGKLQTCPYCKEKVDLKRMFKNPWEKPHLFYGKLLDWIRYLAVWQPIIVAVVHLINGYLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSK3</accession>
    <name>A0A914HSK3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSK3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4089.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4089.t1"/>
        <property type="gene ID" value="Gr19_v10_g4089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03230">
        <property type="entry name" value="FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046401">
        <property type="entry name" value="FITM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4089.t1"/>
        </source>
    </evidence>
    <sequence length="329" mass="38127" checksum="46B2462026BCEAD2" modified="2023-02-22" version="1">MLIIRYIPAIEFAYLSYYSMTLSDTSNRQQSNGSRNADLHRSVTEAVEANGTQQNGGGNFLTAPTSFHDVLLGVLTQLARKYLFIDAQKKAMFYLAIVAIFSLFSQTTELPGGFYLTQKHNVFNQFGTKLGWFWTMILLLPFVWLTSLLHHESKLKAAFDLFRLLVATAFWYIFTSCFVKFELHTGKCHGSTGTVRPNCYENGGKWIPGFDISGHAFLLIYSILIICEESTSFQNWPSKPRVTVQHVPSREEFVHFQQKTKFIQWNFVLLLILHLVWDLQLGITSLYYHEFWQKLIGACIGVFSWFVTYRFWFVVGFPFLPIRRHIKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTL9</accession>
    <name>A0A914HTL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4104.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4104.t1"/>
        <property type="gene ID" value="Gr19_v10_g4104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4104.t1"/>
        </source>
    </evidence>
    <sequence length="323" mass="31860" checksum="7A8AEBE128066F69" modified="2023-02-22" version="1">MGQSSPKVHSVRPSVVGCEIMQMHFQITPSKMTVDRRLHSLKVNGSPPTSSPMSPIIFLFPSDLSFFTKYQSNFPKLRNEWTVLLFMYPSSPISNHLLNRKFLLLTEYFDQNHSPMSPLISVQLSFFLIVARSALGQWGGGMDGGGGGGMPDGGMGGGMPDGGMGGGDMGGSMSMGGGGMGGGDMSGMGGGMMGGGMMGGGDMGGGGGGGGMGYGGGMGGGGGMAMGGSSMGMGGGMSAGGGMTGGGGGGGMPMDGGMSGGGMEGGGMGGFGGGGFGSNMGGGSPSSYGTSKGNFNPQASFRNVGSVWPSATHPNTALFGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTP0</accession>
    <name>A0A914HTP0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTP0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4574.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4574.t1"/>
        <property type="gene ID" value="Gr19_v10_g4574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4574.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44239" checksum="E83818B10D1C5766" modified="2023-02-22" version="1">MSSSSSKCHHLHQNVIIFIKMSSSSSKCHHLHQNVIIFIKMSSSSSKCHHLHQNVIIFIKMSSSSSKCHHLHQNVIIFIKMSSSSSKCHHLHQMSSSSSKCHHLHQNVIIFIKMSSSSSKCHHLHQNVIIFIKMSSSSSKCHHLHQNVIIFIKMSSSSSKCHHLHQNVIIFIKMSSSSNSSSSSNVIYLHQNVIISSNVIIFTNVHHLHQNVIIFIKMSSSSSKCHHLHQNVIIFIKMSSSSSKCHHLHQNVIMFIVLIEPCGLDARNKFKINTAKIAIAASGINGGVLPLQDTLHHAVLVYFVCGKCGNKNRRTYELTSDGKQSRSNISNEYLINNLFNSSSALPTPNECNHLLKLNLNPFSLMNILIGTPLLVLQLMTLPAIILYVGMGLLIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU88</accession>
    <name>A0A914HU88_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 9">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19890"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914HU88"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4243.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4243.t1"/>
        <property type="gene ID" value="Gr19_v10_g4243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4243.t1"/>
        </source>
    </evidence>
    <sequence length="507" mass="57223" checksum="B4429892D9BD86CB" modified="2023-02-22" version="1">MECSAKQLTTLDATPKKLGFAESSAEWKTSTKRETYALLEQELTKLLCTAPPEKLEYWKKEFDNFLTLFARFLRAKTTVEWSKIQPLPEGAIIPYAQLESTPREHVRELLSSLVVVKLNGGLGTSMGCKGPKSIISVRNELTFLDLTLQQIQSLNKEYDVNVPLVLMNSFNTDDDTQKLLKKYTNVRVEVHSFAQSRYPRVDRESFVPIAKDLKDNDMECWYPPGHGNFFESLVNSGLLDKFLQQGKKHVFLSNIDNLGATVDSNILSYMVARKAEFIMEVTDKTRADVKGGTLISYEGKLMLLEIAQVPDDYVDEFKSVSKFRIFNTNNLWAELDAIKRVVQNKELNMEVIVNPKHLDRGVDVIQLETAAGAACKCFRGACGINVPRSRFLPVKKTSDLLLLMSNLYDIENGYVTLSTLRSFPTTPLVKLGNCFDKVKEFVKRFQGIPDLLELDHLTVSGDVWFGRDVTLKGTVIIIANHGDRIDIPTGTILENKIVSGNLRILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV85</accession>
    <name>A0A914HV85_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HV85"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4484.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4484.t2"/>
        <property type="gene ID" value="Gr19_v10_g4484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4484.t2"/>
        </source>
    </evidence>
    <sequence length="209" mass="23560" checksum="261C0BFB244CB67B" modified="2023-02-22" version="1">MEELVEQAIIWWRPSSGRPVNGHLETLVVWNRCGATPFFERQKRELCVGCPVGHLNCTDRVGSSDHLNCFGEDALDQLMLVKTCWSFIDHQSLRSVKSAVVAAKTHTIRAMTAQIAAGDTPSPAAPPRHISPSQMKGGGSTTKKGTKTLQNYLRRASVAYFVEWTNCYTNFRGDLDTIHIHFPFRCCNFLSIYFCENHRADDIFVSYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVK4</accession>
    <name>A0A914HVK4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVK4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4890.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4890.t1"/>
        <property type="gene ID" value="Gr19_v10_g4890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4890.t1"/>
        </source>
    </evidence>
    <sequence length="765" mass="88561" checksum="1F59BBD4846B6741" modified="2023-02-22" version="1">MQSEQQQQKEEEELLKFIQEANAQKEAVERKITLAKIVNQKLTENLESTRRERENEMAKVDMLKRHVEDVVKAEQYADWHVNKIKLELKRRTALNAEVQKLIAMIHQNPLEPEIEKAEKAFSSFHADLAKAPWLPEKREIQEEFKKYRDELTRVREDIAEYVEAIAKIKENADLHGKLPFKVFCLTLANYHSKSSKIRRLAKKEAEVSKQLKEKLLQVSCDVEMQESGEQNTAELGAVGGGQQQQHVAVDNHNDIPVEQQQHCVETNNPNFTFGVQQQQRVVEAKNPNDTVRELRQVHVDENNQNNIVGEQQQQRVVEENTQHISNNNVLDLSASFLNNDGEEAQFATPIPPVSVPRCCDDGDPQPLFDFFGGATGADQSGIDSSFNFGSFINFGGPSANKGQQQPHGDAPGDSQTEFNFNAFLDKPNDSNKDGTGGLCVEVNLRLSSHDLLMDSGWTTMETVVTSLIDDKLNDLPQLKKMQLEQEASIGLLVRKVDGLLRGNASEITAAVLSNKFDVKAHQNLRQRLCNATEAIDSETDRLENEYFSLQEQISAMKQLIVVRKRRHIEEQQKKKEEEEEMEKRLAEEEEERTKKRKEEIEKMDGKKRRAEEERKRVVDEVQEKNKLEREGKKRREEEEERQKRKRMVDERKKRELVKAIRLEQEKEEQRHKKKLEEEPNKMEGKRRQICAFKVPVKLKSKRMLRSPSVDQQKEQQQHSKKLRPDLTITPQKAKKKSLVYYTPDHNKTMDTCYDEDDSFWIDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVN0</accession>
    <name>A0A914HVN0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVN0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4592.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4592.t1"/>
        <property type="gene ID" value="Gr19_v10_g4592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4592.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53593" checksum="EC5779C781A06F4B" modified="2023-02-22" version="1">MDKNSENTQEQQLNEPNERIFVLEKKCKQLEEINAIFCDEDEQRCNQIDAIEKENRELKKDNAFKAKQIQQEREENKQLKEALEKEQKKAEEMRSAVRIGFKASRMKSPSGASTASSCSRSSSSTAGFASPVHSLAAAASSFGKHKISGDLWSPSFTPKQNSNTSSIVSFSSNKNTSTLCSSSSSQRLDDEDCNLGNQLRAFIDVEQFSSNGEQREKDSDVFDVNIEEGRDSGNFSDQDQQGVSGEVFNVPAVGKFDGMSLAEELMLAEQHQQQNNVEEPVLAVQHQQQNNVEEPVLAVQHQQQNNVEEPVLAVQHQQQNNVEALLAVQYQQQNIVEEPELAVQHQLQNNMNELLELAEWHQQQNNVEAELAVQHQQQNNIDEQELAEQQNNNSNTPRGARPRLHFFLLLLLFVLVVVVFVLIVVLPSVLRGQLVMRIPVFFASWLREHMLRGTNVVVHTEVMWHSNGLFGGGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWP8</accession>
    <name>A0A914HWP8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4717.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4717.t1"/>
        <property type="gene ID" value="Gr19_v10_g4717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4717.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13041" checksum="CB8BCBB67409EDA8" modified="2023-02-22" version="1">MDVLSGTCTRLRFLPAPFSRLRFRGSVFAGSVFAAPFSFGSVFVAPFSRLRFRLAPFSWLRFRGSVFAAPFSGVPLLASVAMGPLIGKDPSALVHRSHELTLIVAAATQIAFPCLPFSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWZ9</accession>
    <name>A0A914HWZ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWZ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4800.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4800.t1"/>
        <property type="gene ID" value="Gr19_v10_g4800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF28">
        <property type="entry name" value="NEUROPILIN AND TOLLOID-LIKE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4800.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23643" checksum="F6604CBDAB2220C6" modified="2023-02-22" version="1">MLNIFSVVGIGGNFCPSQNGGTKLNELTSPAFPSKYPSNSDCIRIIDAPDAYEIAIQFRDIFQIEAAYELAGHVERFDSFTSYNCPNDFLELRDGQFPFSPLLARFCGMSVPTMEIRAKSGHLWTWFHSDALFEYRGFVSDYNFIKRKLNDGNEIGKKKDCHFPLINHLDGYIDSKDLMQIYKDRDPEEELECVWTIQVHFEHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ47</accession>
    <name>A0A914HZ47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5821.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5821.t2"/>
        <property type="gene ID" value="Gr19_v10_g5821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5821.t2"/>
        </source>
    </evidence>
    <sequence length="692" mass="75616" checksum="F554FC07AA0340AE" modified="2023-02-22" version="1">MSGALHTLLAKLTDHNQSEKTTTPTSPRQQSPSPNAFTTTEIEMAKALCSLPSNGREERLEEETKGQRLLTNVKEEGKRTKSEEFDEGKVVGEGTAGDATRPIDRQISVHSSSEKIFLNANFESFTEFDSAFEEWKSLYKHPFRVASSEKHHDSKFKYRYVVYHCSRYGEPRKRGQGRRPHQNYLPCGCLAKLRLNFHPQPGEGCLCVTTLHTEHNHEPMSECHSMWLKRRKSSPEEDAAGPERSGDGRDFESSTMSGEHSPNSTASSSTALFSPLSLHAPQPHHLLHNSPSSSGGQSSSDSGGSSSSGGEAVVAALLMKAMPTSPLSDAIGGGKTQRQTIGRPPSGMFMDTGELGTATISQPLSAEFKHPLLGTVPSQPPQFVHGASNHQQQQHSLLLSTLKTALMANGNKDGAQIGGLGQTYKKLIGELFRQQQQRTSADQRQIDQQQQWHIMPIIQELLRLEQQQQQQQQQQQQQQQPVLNRNTNHSQNGNQNQSTLFALISQSLQRDHHANNAAGTSATALFSALRSMNIPPTPPMPASSSTGFFTTPQSPTSSSSASSLLHRPAAASPLIGLLQQAHLISALGQPYGAGGGTQRLSPPHAQQQQNVCGTTNFGNGTAAFIAQQLQFGGEKQRREQQQMVDNTLNMGRAEIIKEADLLLQALVNQMIHSKDLVSYLARLRQFLADSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ78</accession>
    <name>A0A914HZ78_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
            <location evidence="1 13">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5148.t3">
        <property type="protein sequence ID" value="Gr19_v10_g5148.t3"/>
        <property type="gene ID" value="Gr19_v10_g5148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="15">
        <location>
            <begin position="49"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="981"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1046"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1194"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1283"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1331"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1056"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1194"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1293"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1336"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1366"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5148.t3"/>
        </source>
    </evidence>
    <sequence length="1561" mass="176889" checksum="3177F0C5D5F79071" modified="2023-02-22" version="1">MTNSRDTTRKETVGFCCLTWHVFETAFEGVGERDGRRGSACRRRRVQKVCAMQRKANSKPMSSIMAKMGEFYKDYLDFIIFPEETILSEAVENWPLCDCLISFHSTDFPLKKAIEYEKLRRPYVLNDLHRQFDLLDRRKVFRTLARAGIDHPRHCVLIRNEKGELVGDELREFADHIEVNGMTFNKPFVEKPVNAEDHNIYIYYPSSVGGGSQRLFRKVNDRSSWYSPVSTVRKEGSYLYEEFIPADGTDVKVYAVGPYYAHAEARKAPGLDGKVERDADGKEVRYPVILSAKEKTIARRVVLAFGSVCGFDLLRANGCSYVCDVNGFSFVKTSTKYYEDTAKILGNTILRRLASSLSIPWHIPFQDDDPPLVSTPSGKIMELRCVLAVIRHGDRTPKQKMKVAVKDERFWKMFQKYDGLRKRELKLKKPTQLMEILEIVRQLLQESLEQRRSLLGKNTHFLWEKRDGSASVGAEHSLTNELEKCEEAIKTWEQMRAVLEMYGHFSGINRKVQLKYLKTRTEKGTAGSKGSFVLEAGKSVLQNPSGALGDDDSQFASVPTLFLILKWGGELTTAGVLQAEALGRLFRTLYPGIRRTDGKESPEDTQGLGFLRLHSTYRHDLKIYSSDEGRVQMTAAAFARGLLALEGELTPILMQMVKSANTDGLLNDDYNARQFQNDIKSFLHSALQEDRDFTPSDYQSLNPSGLRSINNALEFIKNARKMCHEIAGYVQRMCEIIRWHKLNLNNTERTLYLNETWDLAERRWTKELREFRKPSKNGAGDGFDFDISKIPDIYDNIKYDMEHNPDLCINNEGEFERFYLCVKNMADIVVPQEYGINEESKICIAQRSTSNEAGDESLTRLDPRASEGIATPMRHVRTRLYFTSESHIHTLMNLIRYGGLCSPDDKKWQRAMNFLSGVTEFNYMTQLVLMVYEDSRTEEEKSEGGRQQGTDIKDRFHIELLFSPGLYPCFQTEKERIYESRYSNRHKTSTSDGNKCTKGNRHNNSTAAGGGNENTLSGCGEDKVYSSASLATKLTEVLDIGKFSENSQIDDCPTRESASTQPKCSNRAGNESTSEESYTKEEGNGGTYRQNSRKSADDDDDLPEENAVNLVVLDEVSAASGAKTFCKGDLARHSPTSMEHPMRKRHATFERDSLKTLSKSREEGTKVKEKTMSEFEKKCEDGNGVGERLITFERRESDGRERQERPHGHQHYQKSIVKSMSDLFANRQKLEEIANDDEDDFKSDVNDGGCAPSGVIAQSANELKLDEGQATVGHGRGEWAKQLLEGTKVKEGQSPTKQQNVSGDIGIGEDVRPNCSSTNIARIPLSSVFEGISTDGQKEGADGSDRSTEEETNRRKKEQQKDTNSKEQTIGTRNSPDTTESTESTIHTQQSSATIKDEDTEEHNRLSFRRTRFPYRFKHHTVNLLTGAATENRLISTDVLMGKFSDKTKRKASSNSVVLSTAVIGVRSSSAPRLQTYNAGDELSVNEIRRFWPPLRSLETMHDNLSWKEVDEFLKRMMKNCTPLPSPPKTPATHFDESVPMLFADKRKSDSTICRLPPLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZK0</accession>
    <name>A0A914HZK0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZK0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5482.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5482.t1"/>
        <property type="gene ID" value="Gr19_v10_g5482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5482.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15639" checksum="A3E576603784D06F" modified="2023-02-22" version="1">MDANKWHTFVNQLAASGPISKAAICGQDGSIWAKSDNFNLDPMEANVVVNAFKNPNSTPNRSISAEGVMYPVTQPPATTNNICLSGVIDDQHGITVAKTSRAFLFGVTEGTDVDVGRAETVSLAQQLATQYGWTSPFQVLRRPNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I008</accession>
    <name>A0A914I008_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 9">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>L-histidine = trans-urocanate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914I008"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5610.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5610.t1"/>
        <property type="gene ID" value="Gr19_v10_g5610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006548">
        <property type="term" value="P:L-histidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000005">
        <property type="entry name" value="Histidine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000003">
        <property type="entry name" value="Histidine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006871">
        <property type="entry name" value="PRK09367.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5610.t1"/>
        </source>
    </evidence>
    <sequence length="594" mass="64831" checksum="CFB37CE4C06A8B9B" modified="2023-02-22" version="1">MSSSLNYESLADQLDSISIERDAIVGDATADDSDFEKSDEGIEEEHPNKQRILQLDGNTLKVQDLVDCMQDKCRLQLDESARQRIRKARVFLEKVAAEHRVVYGITTGFGTFSNVVIPPGELKQLQLNLIRSHATGHGEPLDPATARMLLALRINVLAKGHSGISLENVDKLVKAFNAFCVSYVPEQGTVGCSGDLCPLAHLALGLIGEGRMWSPRTGWADAGEVLAINSLEPMALGFKEGLALINGTQLVSALGSLAVVRAENVAKQADVIAALTLDVLKGTTRAFDANIHRVRPHRGQNVVAGRLRALLHSDLNRSEIAESHRNCGKVQDAYTLRCVPQVHGVVHDTIEFVKSVLETEINSATDNPLVFSEIEEVISGGNFHGEYPAKVLDYLAIAVHELAQMSERRLERLLNHELSGLPTFLTQNGGLNSGLMTVQLCAASLVSENKVLCHPSSADSIPTSCNQEDHVSMGGFSARKALKVVEHTEAVVAMELMAACQGMEFLKPLKSTDALQKVYDLVRTVAPALEQDRFMQPEIQKVIGLVRSNRVWKVVEQHLERMGRMESNIPTLLRQEAESPTAAVLAGTDFSRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I161</accession>
    <name>A0A914I161_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I161"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5916.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5916.t1"/>
        <property type="gene ID" value="Gr19_v10_g5916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="238"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5916.t1"/>
        </source>
    </evidence>
    <sequence length="655" mass="73107" checksum="F1CDF1C112154C83" modified="2023-02-22" version="1">MLFLTEPINGDITNQNPSEELRLLRARIVQLERQQTINPPASSSAGFDLVAQNGKRRRIEGSDQGGSKETQELVSKKLEQMEEWKTITKLEFENKALRAELAHQKLLNAHNALHTKMEEYQNKQQQTIDGLTKKLTVSIDQFSLKHQEHEKLLNAYNNLIEEMKEKRKLDKKEINDKISCLNGDQQKLSVGQRNEMRLEMNESLSCVQARVGAKLEKQKVSNANKIVKLKAYQEEQKQNISDLQKTVADVLNGKGIPQQNRWDSAACHDKLTLSEPDRLIVEITEKDKWAWRSVLAEQPIEKNCGIFYYEVKILVDGDGIHIGLGTEQMPLNKWVGSYKGTYAYGDDGTFWGHAFKGCSLATNGRPYIDGKPCFGAGDVIGCGVDLATRQIIYTKNGKRLGTVNLFVDSADELFPCVTLADSGDKIVAYFGPKIRSTELTHYKIFINEVFRCCWSFNPCEIVFMSALTNKVRLRNAFAKMADIASSQKLQLLLTPVHRQSDGGRPQAEVGSDSPGQSPNGAPLAKVFKEGGGGRLSSGSVESTQKRTIKIETLSGKAVSLAKGAVEALTNASKKRHTTKFACGRRGCASWKWFFPHHHAHHSTHWSSRSKQEERKKATTATEMESVEAAVGEEGGEMKQQSAKQLPTDQKTARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2Z7</accession>
    <name>A0A914I2Z7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I2Z7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6387.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6387.t1"/>
        <property type="gene ID" value="Gr19_v10_g6387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="33"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6387.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13001" checksum="5DBD64D75E5353B2" modified="2023-02-22" version="1">MSKLADLQFALSTQPPPPPPTGHGIAAGVGGSTNTVVYMTDGGPTQWGPRSQNALCKNCGQQMVTSVKYTAGLITWLLCGCCVLFGCWLCCCLPFCMSDCQNTEHYCAECKTYLGRYQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I385</accession>
    <name>A0A914I385_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I385"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6465.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6465.t1"/>
        <property type="gene ID" value="Gr19_v10_g6465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6465.t1"/>
        </source>
    </evidence>
    <sequence length="446" mass="49744" checksum="EE6D93693137A313" modified="2023-02-22" version="1">MQSAPFHKIDRDSGNAVSSALAFFDIPDTDVSLSHSSNVEYLTLNPVNITPYHFKIHASSDYIDLSKCYIFTELRIRKEQGGEMKNLVAADDVSMCQMIGHTLWKNCRMSINGTQVFEGNDLMAYKSVMDYELTYPESVKRSYLNIAGYYMDAEDSQVTGAGYTARRALFAQSKTAQFIARLDVDPCNQPRYIVNQCEVDIELLPHSSQFVILAPNAPTSPAEDVRQYHLEVISCKLYVKKAEVMDSLALDISKKLELRPARYPLRKTSMKALFISENRTEFTANLWSDQVPKRIVLGLVSNASYVGSAATSPFDFRPFDVRDISICASGRTHPQAQYSLDFPNGRFARIYHDTQEAVGYAGTLDSNGISMKRYSQGGQCFFVFNLAPSAENAADTFDLIRKGTTAIRISFNAPVPARGIVLIGMAEIDALLMLDKNRTVASDVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I388</accession>
    <name>A0A914I388_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6422.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6422.t1"/>
        <property type="gene ID" value="Gr19_v10_g6422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="568"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6422.t1"/>
        </source>
    </evidence>
    <sequence length="1301" mass="149370" checksum="90E12106872D309C" modified="2023-02-22" version="1">MIISGPSSSGKSTFLLNLVAEYRELIDPTPASILYCFGEMSTIVPVLQKAGISVYAGVPPEELIRRQTKPLLLILDDLLMSIDEKYLSELFTKKSHHQNFAVVFVTQNLFERKIRVARQNAQYVVLMRSPNSVLAVRNLGNQLPYGYLVIDMSASSDPVLRLRTGIFKEDEERVIFIPKNGGQPPLVCGNSKFLCGLARTRSAKKRTKMLRNANAEQLLSLVEICLNIVATRFTLTTHQKKRLMPYADFVRRMSRARSERGLTAASDTGDINLDAVRHELQRARSERANPSAKNVRYNQQLRRYLHMRKDYESKPTKVELSKGLSLLVKRGGEEEAEVVDIPQPPAQRQHSIQQTQRSGVNTPQPPAQDTLEPPPLHKEAARRFQQRVSRKRAALKQPTRNEPERDLVAEAAAAPLPYDVDDDDYLLEDGSTLSVPSGNSDELILPDSDDDTWPMEGYNERRIATKRKAGTNEDDDQPLQREGGGRRPSKSISVGSRTPLPSPKVELIKAALDPLYNDLSSPSAFAGVEGLQREARKKLDRNKLNISKKDVQNYLEGHRTYTLLRPRRVRFPRAKTVAAGFMTDVQVDLADLQTLSRHNRGYRYLLVAVDVLSKRLFVVPLHTKRAEDMLQAFKQLIEQMPMAPHRIFSDKGTEFRNRLLKEFFDQQDIAKHEPVHSSVKASVAERAIRNVKQRLYRYFAQKETLNWVDVVQKIVDGINKSVSRVHGMRPVDVNFKNAQQVWLRIYGIDDDGGDKKQQRRRRPRFRKDEFVRMSREKGQFEKGYLPNYGDEILTIDAVLEGVHPVRYKLRDERGEKFKGTFYEHELARVRKDAETSYRIEKVYRKRKRPDGSTEMLVKFAGFFVFLPSNVTDYPDNQPNKFRVRLPKSIEFNGSWVCGLHSVSYPYSWHSTIGTLDDQWINIHFLDVFDPQDRDTLRVIRLPVPKASLKKVEQLRDFLATVLKHHSRLLQSLTQNKEVTEFVDRPEILASPPPLKRRKRSTGETLPLPPSVEVDETLPLPPSVEVDKTALPSPPREQNQHLQQKQPQQTKQHHPYSQNQFQHLNQHLQQQKLQKTNQNHPYNQSLLQHLYQHLQQQQQQPHQTKQPNSYIKNELQHLKQHLQSRYLHDLGAPKPGEKERAQQMLSVLVGEDRVKSSAIEYLKAIVDSVDIQYEEVFERFKLVVNRAGVSHLSFSPQLGYVLGFQNPPYVRHNEIAKYGCDLRENVIIGNTLSSLLRVVSVTGAVQGEYNEKIYDSPIYARVLPREISEIEIELRTMDSGRLVPFAYGTTMVVLIFKKVINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3R1</accession>
    <name>A0A914I3R1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TATA box-binding protein-associated factor RNA polymerase I subunit B</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3R1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6603.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6603.t1"/>
        <property type="gene ID" value="Gr19_v10_g6603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005668">
        <property type="term" value="C:RNA polymerase transcription factor SL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6603.t1"/>
        </source>
    </evidence>
    <sequence length="739" mass="84661" checksum="CBA4460F18BF3C58" modified="2023-02-22" version="1">MSSADDDGGGGHKMFCEACGGTGFTLDSGFYYCRQCGEQSKGHRETEIEYQGAVGVNLKRSQKKAERSAEDLKHQQERTRKLRADPHLCERALAHEGDFPAYLDTLGTRLCTATKLVAKMANVLTDEPFRLPKRCVHFSQLFLFTYFREANIAFCECETDDDPTKTFCPLVKRTKTELMRMRRERETQAKEKRAQRRRERLEQSTVWEQLTRTFTADDNESDEGEDAGDVPLPEEEPISLFRRLNTALSIRSVNLAGVLYLGIDLLLCIVFMATQMAGARWVQLSDIFRWYREGRFTVSHSQLCALNFATSWDIDNGRSNAEFQAKRLTKRFYWRSIFQTPYYGLQANSESFRVLSFLTQFVGIPKSIQTAPFKDVLFRLLYNLNLPRAFERQLNALLDVLPPPMFTDYGALRLRAGIPMIEKDVLLERLHFVATGVGTGISGGSRVGYVTFLRYAFDEPSEERIRLREYLKMCKDRRRHVPWKWLPLPSELNAAALMLFALKMFFGLGEQSDDDDARASRRQPMGGGGGGGRAADVAENAVENGAGGGDDEAEPFNFKHWLLQLQLRMHCWQGTPAHVVLDKGFSACQLERSNTEVPYRRPEVSAMNTFSLGGSRLFHRHRKQAFAGCVPNMHRLFEDLLPNWHCLPISQSAYVAVSNEELYAPLQHQCLLNRALLDIVQRRHRRDKEQALVNRLHKRNMNIFFRNFYGSNLTPYFHRHTELEDEEQIGTPPLQQPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I429</accession>
    <name>A0A914I429_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I429"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6693.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6693.t1"/>
        <property type="gene ID" value="Gr19_v10_g6693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6693.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33060" checksum="AF8D0F472584EF44" modified="2023-02-22" version="1">MTSTQQKHFKGFEPEESDEVENVSMKVHQQAKRVKYRSVTVHMKYVGREVLTEDGGVNAGDGEKRMQEEGGKEASDGEKRTEEEGGKEASDGEKRMEDEGEKETSDGEKRMQEEGRKEAASDGEKRMQQEGGKEASDGEERMEEEGGKEASDGEKRMQEEGGKEAGDGEKRMEEEGGKEASDGEKRMEEEGGKKASDGEKRTEEEGGKEASDGEKRMQEEGGKEASDGEKRMQEEGGKETSDGEKRMQEEGGKEASDGQKRMQEEGGKEASDGKNNDKTFTYILVDNPVDDPINVFIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I495</accession>
    <name>A0A914I495_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914I495"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6748.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6748.t1"/>
        <property type="gene ID" value="Gr19_v10_g6748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6748.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="45587" checksum="57B7409D4321C58A" modified="2023-02-22" version="1">MPLRYISSSTIHSDGIRNQTDGNALCGTKPWGHINTFSTNLRAKMEAEDSAATTAAAGGTSPTTNRSVSGGDVATSTALHGGDADSDDAKQTAREMDEAVASAAGGGARITDLDRQIETLMRCECLTEQEVKVLCAKAREILLQEGNVQRIDAPVTVCGDVHGQFHDLMELFRVGGQVPDTNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRMMLIRGNHESRQITQVYGFYDECFRKYGSAVVWRCCTEVFDCLSLSAVINGRIFCVHGGLSPSIETIDQIRTIDRKQEVPHDGPMCDLLWSDPEESVGYGVSPRGAGYLFGSDVVKTFCEKNGIEMIARAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEQLNKDFTIFEAAPQENRGAPAKKPQPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4Q2</accession>
    <name>A0A914I4Q2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4Q2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6589.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6589.t1"/>
        <property type="gene ID" value="Gr19_v10_g6589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6589.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41669" checksum="62C91924F2345047" modified="2023-02-22" version="1">MDIYVPQAVSLLLALPSVLLYVTECVVILRFWRHCFATSFFRLFLLLAANNLLLNFVLYIPSMRISEVGLFYELYMSMPDWVPKTFFCLSFFTFHFENFLTMVVIAHRLSAIVRPLDFEELWSRFFLIVVAAGVLICLALITPIALMDNIHFNADIKRTQIKRIVVSYRFRPGEKVFNAYKFLFICSVLALATSTALNLATIFAYKWHKRTRTATLTRQRTGGESCGHFGIPSPRLYSCNVLWSSAAFGLLYFCLFVHLGLRVVPASLVHSRQPVHFAERPPFSVRTNALFNAIFGGALNTFEKCGCCCMAKAFDKIKITMTKRRRGSMVVPIVNSVQHQDNDASDHYCEHRTRLEVLRRAAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I644</accession>
    <name>A0A914I644_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A914I644"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7854.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7854.t1"/>
        <property type="gene ID" value="Gr19_v10_g7854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000033">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000147">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF451">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1004"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1076"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7854.t1"/>
        </source>
    </evidence>
    <sequence length="1277" mass="139339" checksum="77012C845AB35131" modified="2023-02-22" version="1">MAKEASTNARGFDVSRKELCSLMELRGAAALEKIAADYGGHEGLCAKLQTDPVNGLPISAAELERRRNAFGRNEIPPVPPKSFLRLAWEALQDVTLLILLAAAVISLVLSFYKPPNRDEFSALSAHVAATTPSSDGGGGGGGGGGGGDQSSGLTEQHAGWIEGAAILIAIIVVVLVTALNDWSKEKQFRGLQCKIETEHKFSVIRDGKALDIVISEMVVGDIARVKYGDLLPTDGILLQSNDLKIDESTLTGESDHIRKSPETDPILLSGTHAMEGSGRMVVTAVGVHSQTGIIMTLLGVTKSAGGEAQTSSSSTQNTQNSVSSIAAKSANRNGQPLNGDSLKAVANGQMVAASMPADVPSPPLNSNGAPVAPMPVEDNSKTKSVLQGKLSNLAVQIGYIGSVVAAATVLVLIVKFSLHKYVWGPEEKRHFEAKDITNFVDSIIIGVTVLVIAVPEGLPLAITLALTYSVKKMMKDNNLVRHLAACETMGNATSICSDKTGTLTTNRMTVVQSFVNSRFYKDNSPSWDELDLRTRDILVEGISVNSGYNTQVMLPTTQGTQKTQIGNKTECALLGFVLDLGQSYEEFRRKFPEESLLKVFTFNSVRKSMMTLIRRNEGGGFRLYAKGASEIILSRCTYILGAEGRVTPFGERQQRELIQTVIEPMASDGLRTIGLAYKDYVPVNGEPNEFPLDGVDVNWDDEESLREGMTAVAVLGIQDPVRPEVPEAIAKCQRAGITVRMVTGDNINTARSIATQCGILRPGEDFLALEGKEFNSRTRDSDGVVDQRKLDQIWPKLRVLARAQPTDKYVLVKGIIESKCTKNREVVAVTGDGTNDAPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVTIAFVGACATKDSPLRAVQMLWVNLIMDTLASLALATEMPTEDLLKRKPYGRTKSLISRTMVKNIIGHGIYQLAVLFGLLFFGEKFIPDLEQERARELPHEAAPTMHFTIIFNTFVLMTLFNEINSRKIHGERNVFKGLFANPIFCAIWIITLVSQILIVEFGGRWFSTAPLTAIQWSYCFLFGLFELIWGQIIVTIPSNVLPKFFAFGRGEVQPTSILVTGEYDIPEIRQTGGREIGGVPAPSAAARPGQILWLLGLTRLQTQMRVVKAFQSTLQNSHPSSLTLQAGDRLRQSYRRLRIAKEIERANELRSRGPIRAVDPEKKPKSADLNALSRRCLLCTRQEIVLVTNQNHQQQKNVDYFNTFIYNNGMNTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6B8</accession>
    <name>A0A914I6B8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6B8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7169.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7169.t1"/>
        <property type="gene ID" value="Gr19_v10_g7169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7169.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20373" checksum="44E5F26012EE617B" modified="2023-02-22" version="1">MLGREPGVRHVFDLRSEVQAVQPLRSFVKLSNNKQHSTRPLCLIIEIYVLLLLLGHRFPKEVRPQISQMSRSTNLVEPEPLATVSLEQFAKAMRKEVLGQVELRQRQKQRPHQQQIDEVEGGLGTAFIASPQRREGGAENNTVLSMLKDFPSRLTPRPSPTRRCRAQTNRERTASTSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6J5</accession>
    <name>A0A914I6J5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6J5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7968.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7968.t1"/>
        <property type="gene ID" value="Gr19_v10_g7968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7968.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8734" checksum="81240C0FDEF414B1" modified="2023-02-22" version="1">MVPLTTALSKLLNCKAENLAEYLNNPEAVNKASVYLTGKTLKTTYLSRDGTTKQSCWPLTRVPKEATRRLKTTTTWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6S9</accession>
    <name>A0A914I6S9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6S9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7833.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7833.t2"/>
        <property type="gene ID" value="Gr19_v10_g7833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7833.t2"/>
        </source>
    </evidence>
    <sequence length="242" mass="26854" checksum="8264F8D7F16491EF" modified="2023-02-22" version="1">MSNVQQQTATGLAAEDEDSADEYVVIQQEEETDSGKSSTKSVSTAMKTESVPSDAQSLTPSVGTLGALADIGDGLDGDKLSVSAVSPRTAMNESSYSQNIFNSSIFGSFVVEDQLRELVRSENEQNRQVLDSIKNTLGELSKQKSNNNELNELILLHKMSLEKTLEEMVHQLSQERDRSTAMVAKSKEEVASKDEIINVLREELDDQHGMHEARVKVWRERMDSLERMLVSQQERAEVNNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7I3</accession>
    <name>A0A914I7I3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7I3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7470.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7470.t1"/>
        <property type="gene ID" value="Gr19_v10_g7470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7470.t1"/>
        </source>
    </evidence>
    <sequence length="537" mass="59571" checksum="3D456E1ABE9BD7A0" modified="2023-02-22" version="1">MTFGGSDIPAGSTMSLGPLFPSSAPATSSPLTAPPSSRPSVLRQFRSLTSLNSAGSTTEALTALERGCAKLVRIEGDSANSAKNRGRTIWKNSSCREPLLERSRSLNTQKPIHWSTFNRTTLAFQLLFTPFGYPGIRLFGLRNFSVSMYTAPAFMACAMNCVNAVCIRTMFAENYVGVHAEQQQKSDASTADNDDNSASKLPPYDRRAALLCYGTRFTQMFVNTNLETLGAPLAMMMFAWTRADAVKYISIAQVAMSLLAFLTYVVFIVFRVDKVLSDRTNLVMSLVVLITFHVLTYSYPFLPGHVQTFRHRDLRNHSIPEPVGCDIDKFTWCDTVRPIHPVYFYICYVFCIGLAFPNINVSLNTLFSKVIGPRRQGTQQGVLQMSGGFARMLGPVLISSLYTSYGPQSAWMVELTVVSATLALWMMLFGRMVPLRLPSESVVQHPQQQHQQFEGPKAVVPSSTMFETRAISDQPLATTSSAVTTSRRRIRSLRSREERMPLVEPIDEGDEARTDMEDGAVVLNRNDTTVSTMASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9H7</accession>
    <name>A0A914I9H7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Round spermatid basic protein 1-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the round spermatid basic protein 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9H7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7857.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7857.t1"/>
        <property type="gene ID" value="Gr19_v10_g7857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026306">
        <property type="entry name" value="RSBN1/Dpy-2/CEP530"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354:SF11">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354">
        <property type="entry name" value="ROUND SPERMATID BASIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7857.t1"/>
        </source>
    </evidence>
    <sequence length="634" mass="72156" checksum="016C70FAE693DF6E" modified="2023-02-22" version="1">MESDSMDISSSSSSYSSSPAPLPDVPYSSPAVKAISSTTNTISKLPLQDNDNKRAPKLNTATDRRSPSTNVNRQNLIQKQHSVASEMFLATDPILMDLQKANKKMETQKRKWTEEERDHNSPQTKRPLRDKVDAKKMDHNIVPGKQLDHSLSGHRIDNSISHKSNGSISIAPDNKLCVPFTIPKLSTSSETSKSSLPSPPTKEDKAEPCLLRVDNDGSNNQLNLTINNDELAQKGPSTSAINGEKSTDRAVSRNKNRRKRETNKLPRISERFRRFIHIETHSNGGASVLRCDWRRLKHDLSSQELNEFAEEFIELGFSELSKVPLFVMCVVEHAIEYLEDLLEYLGTKHPCLPVKMGSLQNKQLVETVQLGHYYEKVVSTYQQGTYRCGPLKEITLVGKKQEECGAYFEHLIERLEECPFLRILMPWSERTICSHKMPSDSDDGPIYWCRPGEQLIRTDEAKFDELKPKQQRRGSASTKQNRSAGIALKALERREILFEDRTPCHADHVTDENKALHTTAAVGLLQAVRNPSERGKIGDRIVKDVICFHAADFERVTDILQLDLYEPPMSQCTQWVEEAKLNALRRDGIRYARFTLRENSVYFMPRKIIHQFRTISACGSVAWHVRLKKYYDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAV7</accession>
    <name>A0A914IAV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9122.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9122.t1"/>
        <property type="gene ID" value="Gr19_v10_g9122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9122.t1"/>
        </source>
    </evidence>
    <sequence length="1041" mass="113927" checksum="CBD840ACA757EF90" modified="2023-02-22" version="1">MASVCAAAAAAASYCSASVASSPTIASAAGARSSSTTAVGKKPRRRHHHNHTNCCCWTAFDVHANVVQYVTIFEDEFVLCGSAVEPNVFAKSILASIKSFNTFRQKRSEWRIADLAAIFGYVCALIDQQFVAETGCLPPRIPTKAVIVVPTRCSLPYQLAVEEAAEAAGFTEAHLICRATALAISYRMMFLDEDDTQLIKLIDDVGTENERRREQAAASKKKKDELIVQLDDNDDDDGDDQQTADNCGWLDKFVAILYACEHCIELIIFDFQPHHLPTLISSKVLFVDNLHSQIDLINNFFCKHLTPLRDNLFKLLTAGEPKLIGLLSTNIKKHIASSCQIVAKSAIRPDTATIFGASLKAVHLMLGGKESADRSPLFLNRSMVPDFDYLDNDDGTNVDAVVDDQAKQKMEEIEAIDESFNKAFGLIEQKSPKPKLIEQYEEHEEEEEEEAEEARSFTYENDSPKLIDRKDTTANDAESEEEAFLAGILAGEQPPGAKKQLTDDEMQLLSDVIKFDRTFDAMPKAERQITTPDASAHAAQHAARVVQSCMQTERHDTASVLPGFTTAGHSTRCDGAGNSRTFAGTTRHHAAGMSRSFSEPTRHDAAAAVGQSFESSAQHAAARIPSVAAATTASHFAETSMHAAASGRSRACTDTAQRHVFAERRHSMDKFGGTECSDVPSSSAKLSTENVDSLEAGNKMKWEETDDDETEGEDDEIATLGDDRSEIVGEPDIPSATPSPQGAVEQSADDSKPVGVDDGGGAKPVLNSWGQRVGVEQWSPANYGRAQRHGRLAGDGRQKTGAEWHLKWSKTKTARSSSRATSTFVTSDDEASTAAGTGAGGFSNVERRRGAVPNVARKKLDSNAQSTQFSADDDDLLLSIFGPERPVAGGQFSEDIERQFYLQLPVCGEGPLSSVQVVGLPLHWIGNKFFQQEFKEWLRIRSGLRTNALINCFVSFSVTATTAFRVCRDGRFSICPYNGAHNGLIVYALLPTPEVAWHVCWACNQFEDDLINYWPNKYEPLKFKPTVTQANRQTFLEETYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBN7</accession>
    <name>A0A914IBN7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBN7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8451.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8451.t1"/>
        <property type="gene ID" value="Gr19_v10_g8451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8451.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20897" checksum="026AD48E82D4F4A2" modified="2023-02-22" version="1">MHHPPRTKTNGWAEGRGGKVVQQMADNKNATGAGSKSLTPVAMAAGSKGKGRRKVSFAFDEFILELQLVGIIEKEQKMCEWEEQMRLKEAEYERMKREIAERDRMITEQARMIAEQARMIEERDGWIRTATGQPELDHMEDEDEEEEQNENVDEAGANEAGYVASRYEPFGAGWARGFSNDVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC16</accession>
    <name>A0A914IC16_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transketolase</fullName>
            <ecNumber evidence="9">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914IC16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8492.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8492.t1"/>
        <property type="gene ID" value="Gr19_v10_g8492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019682">
        <property type="term" value="P:glyceraldehyde-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000129">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000033">
        <property type="entry name" value="Transketolase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051424">
        <property type="entry name" value="Transketolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004559">
        <property type="entry name" value="PRK05899.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195:SF1">
        <property type="entry name" value="FI06132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="351"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00016662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8492.t1"/>
        </source>
    </evidence>
    <sequence length="656" mass="70629" checksum="F40A9B23F0C5270A" modified="2023-02-22" version="1">MHRIVPTNIARLIRTICAESRISLLTSNFIHISSQLLQSKMATNVANVQDAANRMRISSIEQTCAANSGHPTSSCSAAEIVATLFFAEMRYDVQEPRSAAADRFILSKGHACPILYAAWEEAGLLSRDQVLSLRKIDSDIEGHPTPRLNFIDVATGSLGQGLSCAAGMAYAGKYVDKASYRVYCLMGDGESAEGSVWEAAAFASFYKLDNLVAIVDVNRLGQSQETQLQHDIETYVQRFSAFGWNAIGLDGHDIPALLKAYENAKQVRGKPTAIIAKTLKGKGIEGVADLNNQHGKPVPKEKVDAIRALLKTNQRPQWNIPKPIADAPAVNLGIGSIAMSGPPQYKMGEKVATRQAYGNALLKLAEANNRVMALDGDISNSTFSNMVQKKLPDQFVQCYIAEQNLVGVGVGMACRGRLLPHISTFAAFFTRAGDQIRMGAVSFANVKFTGSHCGVSIGEDGPSQMALEDLALFRALPSSVVLYPSDAVSAERATELAANYVGITYTRVSRPATEVLYTSDEKFELGQCKVLRASSQDTILLVGAGVTLYECLKAHDLLKANNVHAAVIDLFSVKPIDVATLTQQARRAGGKVLTVEDHYEAGGVGEAVCGALSDLPDVRVRCLCVRELPRSGPPEALIELYGISANAIVKAVNNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICM6</accession>
    <name>A0A914ICM6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914ICM6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8972.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8972.t1"/>
        <property type="gene ID" value="Gr19_v10_g8972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="235"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="462"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="668"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="757"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8972.t1"/>
        </source>
    </evidence>
    <sequence length="888" mass="99222" checksum="5FE0C8B3BE23F7CE" modified="2023-02-22" version="1">MLDPEYVKSQIKKLSGSTSAEFEQLTTNAQNCSTKTNSSSLRRCKNTLPTHRNSTDSKTQSTMDKWLMPKTKLAELAKVKKYGITTTNNNNGTTEELVPDFAIDEAQKKTRIRKSPQIAPMGGTAMVKKRKMKPNNVTWLDQPSSSCENNDIALPTSYKQNVQDIAASFHTPPRTASSSCKRPANFNTTDDKTMMALHNGNSMPKWPNEAHSFIVGRGARAKQFEGPSAQLQAINAVIEKSFDVFISFPTGAGKSLCYQLPACFHPGVTVVFSPLIALIHDQLAALRARGVPCASLNSTLKTEQRIAIIRDLEGNLPQIRILYLTPESAASDAIRSLIGRLHSRGLINYFIVDEAHCVSTWGHDFRPAYLKLSSLRSCANDIRWVALTATANQKTEADIVEQLQMKNPKKFKSSTYRPNIFYEVIIRESLLPTDALDHMAKFVKKCFASLAKTDGSTPAATKTKDSTDKFAGNGIIYCQTRADCEPIAQLINKKGGIPTDVYHAGLSDIKREEVQQKWMSGEVPVVVATIAFGMGVDKATVRFVVHWNPPQNMANYYQESGRAGRDGHRSFARVYYSRDYHGMMRYKLASSLKQVKTKNVPKQLVEQRKKEIQRGFDKMVEYLEGTGCRHALLGEYFDDRLDACASHCDACKTPQRVRDSLKCMELQQSPATKRAKDAAEGGDASLYGGGRKGQQREAEYYQSMATDDARGDETHGEREERLRVRVFLQKELKKRRRAGEASSPNFSSATNLLMAQQQKVEEGKHGDPSLNPENQGNFPFLRSTDTANLSKIPGLTLRRRDQNRSKLFEELRMNQSSAVVNFGCTEHKMLTTEALHAMGGQLEEQIFISAKIGNIYANRIGAKIFEIRKMTSRGEVYPRPEESEQSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDC5</accession>
    <name>A0A914IDC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9175.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9175.t2"/>
        <property type="gene ID" value="Gr19_v10_g9175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036926505" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9175.t2"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120320" checksum="F0CEA62D1A3FB5C3" modified="2023-02-22" version="1">MVAIVVLPLLLLAVLVDGQNFGAGQGALNAPLPFGGPINPEQLPQMLHQPSLKSGEDIEAPFQNGGPVGQQQSNFNLPPPPPPPTNNFNAPNFNQKRPNFNQNFLPNGQQFSSIRRAQPQLTQQQPRLSQQQTPCPQPTWQKIMEDNVKANDSTATLNAIQSGFARTFKNQIFMLDIKGDGYCNVERDGVSCQAAKLSAEAGITLNGLGGTLQFDQSTVLATTCRGVNKNKIRAATAAGHKQGHNAKIQHDHQTESSGRKTENLHQELESQLNNTGDKRKLARENKKARSSKQKTTDTINVDDDDYENEECANCTSLSSIDQIIHHVAGYLKETQTVVDEQVKNVNDRQKNELIETGTIINTAILGLYVSLQPIYNLSEEPKIFSIILPKMIDGMVAALVEFKELAKDKITKYFDELKWRLVANNNEQAGGISTTRSMIKKLQEILQNVEKKKKGNAKLNNVLMLNINFYINLYNNFYTMLDGQKQLSVINTSPKLLDDWKTLMGTVEFLFQHFQTVKERLLQNNSISLAEAAALTERHEVEEINSDAETQAERQNLEAFLGDDDDASDMEISTNSTDEDCQMVDEELRADQDCQTVEEIRSDQHCQMVEEIRSADSKLLTKQPAAIRHSLTKIGSSSGTKISESPLTKWCTKCDERTKIEATVNQLKYHQNEIHRLNNELSSTHIVPIASSIKTTKAQRINEQKRIQKEITAILNAIGTVIYGFKLAILPMVVQYGTLSSNLKDMTEPVECKLMEYLKITKYRLLADPDIDEAYLNAQTKNLKKFIGNYSSTLKKSKNNKSANKLHNLNVYIHLFNEMHKLLNDFNKSQNFPSNNGGGRVHGQQQQQQTLGNGQKFFVIQRDTNALDGGSPVQFSGMGGSQNTMQPQMAQPQFSQNFASSPPSQPSSFGGSMNQQSFIALQQPQTFVPQQNRMPMPNQQFINRGMAPQFSQRQSAPGTDLPPLMAPPQLAAQNAQEPEASSSAFSSEGVPCPQPVWKEAIEKAIVSNNANASTNTVQKALSLAARGTFIVACAPADRREAFQKKMRLSATGNNYCQVIKNGVWCQAVAMNLGRQGISLGLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEK0</accession>
    <name>A0A914IEK0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEK0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9494.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9494.t1"/>
        <property type="gene ID" value="Gr19_v10_g9494"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g9496.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9496.t1"/>
        <property type="gene ID" value="Gr19_v10_g9496"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g9498.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9498.t1"/>
        <property type="gene ID" value="Gr19_v10_g9498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9494.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9496.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9498.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23193" checksum="EC0BAB83F6AFFBAB" modified="2023-02-22" version="1">MTSRLPEDASHEFDVAKEKHAPMGTWERPDVGNGQKVKRGRSGRTEFYVALFFQVFCSFYVTDSTSHQSGTSGAISSSSRKSVNNKFKQQKSVYNKVKQRKVGNNKHQTAHQVHQTAQQVHKRHDTKQAWTTSPSSTASAQSCTDTHSDVDNESKQHIKRSEWNRPQTNPGQRVQAAHREFKGNSGHCSQYTIGQVVSALVSFSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFN7</accession>
    <name>A0A914IFN7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFN7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9806.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9806.t1"/>
        <property type="gene ID" value="Gr19_v10_g9806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036811192" evidence="1">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9806.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20660" checksum="CDA19EDD7E4AA3A1" modified="2023-02-22" version="1">MFWRATILIVLFATTISADTNILRSALNVLRHILRGGGSYSVVRAERQLVHSAGRSTIKHALKKTGTNLGVNFAGGFVGGAAAETAADLISKKYRLTSHYFPVTVRGPKKIEFFLSQDDFEYAEDLHVFFNEMEKASGTVVPACCYVDEDGIVRMAIRTSSMEIVRSRAITVNRQSYFNCDATCLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFP2</accession>
    <name>A0A914IFP2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFP2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9810.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9810.t1"/>
        <property type="gene ID" value="Gr19_v10_g9810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9810.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13888" checksum="A24F0E8CB20927A4" modified="2023-02-22" version="1">MVQLQFGFEYRYVRVCDGMMLNNKRAQLINEVDALKGMTSVRKLKQLEHAEIKRMQREQKQTTQKISSGHHQQQKQSASSATNAGRTDGRAAAAAGSGLATCSVASSVIVPVELVVDEISNLLCPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR00</accession>
    <name>A0A914GR00_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 9">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914GR00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10384.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10384.t1"/>
        <property type="gene ID" value="Gr19_v10_g10384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10384.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="36548" checksum="643390F710FFDD23" modified="2023-02-22" version="1">MAEEGKGILAADESTGSIGKRFETIGLENTENNRRRYRQLLFATPNFGQNISGVILFDETFRQSTDDGVRFVDVIKKAGAVPGIKVDTGVVPLAGTLDEGTTQGLDKLAERCAEYKKGGCDFAKWRSVLNIGAHKPSHLALMENANVLARYASICQQNGLVPIVEPEVLCDGDHSLERCQKVTELTLAYTYKALADHHIYLEGTLLKPNMVTPGKDHTKASPEQIGFATVTALRRAVPSAVPGVVFLSGGQSEIEATQNLNAINSVTVLKPWTLSFSYGRALQSSVIKKWGGKDENMAGAQTVLLHRAKANGDAQRGQYTGEQAAASAAESLFVAKHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR01</accession>
    <name>A0A914GR01_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g1059.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1059.t2"/>
        <property type="gene ID" value="Gr19_v10_g1059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019815">
        <property type="term" value="C:B cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14334">
        <property type="entry name" value="B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14334:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1546"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1785"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1886"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1896"/>
            <end position="1906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1059.t2"/>
        </source>
    </evidence>
    <sequence length="1906" mass="217236" checksum="ECA84CB09686A228" modified="2023-02-22" version="1">MKRFSENSFFQKFLKERRHETTTTTTTEYKKYSNSHHEEFSSSNGQKEEHFYGRNGNSKSLHFTQSLQDAFQSNSPEDDHRLSKEFPPLQREPRHYQPRNIREEQKELSEHFDGDTFIQSQQQKLFEFREQFNNGNIDRAQQHQQRLNVNPKDAQAVPATQPTAEGRHFRTMAMKRTTERQQQFVERRWQHMSMPPLERHRLLQAQQQTPHDLQADAAERRRERGSSRGFSPFPVFGPFMTNSNSTAAAAAAMPPTPPRQHSMPPQQTCAGAKRTSVPPPSDEMSMSMTTSQYKIVYDQPQHPAPMAASSSGDEWQSAYEFLPQSTKHFATLPPKTAPKPQHLSNSANFVTFAPSPTVENVQCTFNLNKLNAYSRQLATKCIWPMRDSQMFQSVVSVGDPTKVQQLLNESTTLSERQANDEVRKFMGASGTISPPAQLHISQEAQSRQSVKVEFNGPVHFVHTTNLNVSTNNRDNKTPLAEPIERKNGQLDDIQRDKMTISPPVERYIDSVCDFGPIFAEIGQTLKTQNQNYTLTPTGNFRKVEQTKQHNNKDNNNNNNDHVEHKSPEKTAAFTYRIQSAEQQKPFTRRRPSSHELEAQQPAGNVPYLVESTSQCHFARVSAITQEWRLARVPDERAECAVVVTARRQMCRSKDLFARIPNVEMPAYHQNSLCRRPSANYSEKWAQNSASSYQHQTYQSTTNKTTVSPPQCHQKYNCASIEACRWRRHDDAEDALRSALTDVQREQAAARAYSKRCQCAEAERIERAILTISEGLRRPLVSVSKAQAEVKEELLRVRLAQLILNLDPDNDSQHVPRPSADKQMPHGFLTQDYKEALRAPIALLRQKLRLLEHRLVHEDADGIGTELRQISATPPLLRSEEQRRRQETLSVRNGEIARMTPLIGILQHKLSALDGACTRRVHTEQMPQQQQQQFNYRIVENESRPTLYAERKTVHELLKRISGEIETIHELCRRDEVRDRLDAVLGVLKRVAASVDQITATLDGTSGSDAQRRTAQADQMEQQQSAQLEQHFAFEMEDRTRCSPSKLEQAIERREAEKASQIQNKKRTEQLMKEMMAMFRQQQQNQKQFQCQQNQNQQQQSSSTWKNQTLLAQQRLPPTVNRQWVHAVELSAYFARHPTVVAHRVQAIVLTAPGAEPNFVGPAHPTRLQQCAIDLHATQAKGADGMGSEKGTGGKERAYDRMKKRRFDQTPRIIRQQTMPNTLQYDEDVDHIPAFKIGACPPSYLPRDEMPKRQTQSFQQLLEVPTAQQHKFLQLHQQQHYLCSSQDEEAEEDDDDMTASSTSALDSSSLNVPILFRKKLSMCSEPVRETAILTDEEESQEESITEVFFLRRRRKHAMLNAVIYPETKVRLRASLRHGNNFEVVVERVSDCGRDSVVMVSEEFIDKRVLIRSGAPVRHSTVMEEMESSDEGFPTSSPGMLVDAHTKMAISISARSDRDSVHAFLEQIPCGQIGLKVQAPSTPSPTMAPDQRSGQSVGMANSLEWRDSVFRDIKVSEGVADLENSSRSLRSSRRSSQKSLLMIHDGMEEVEDIPAYVIKMGSTASITCELNNDCVELNSKIEWFRGQNEQIVPLGNKFERIREDWTELLVISDVQPEDGQLYSVKINGELYPVAYLIVEEHRDDDEMEGSTPSGQTVVGLWPEPQFLTAPQTQFVLQCETAIISVQMNRANLNVIWHKDGQLLDAKSDEKCADGRPRIWMESTTTGWYRIIVNDVQFSDQGYYFAQLAERQTNVQLIVEERIDEREVQVSSAETDDEELGDYLVPLGSTATIACELENVSFGYELHWQRNHKDLDDRIASGDGKFEHVVNKTKHYLIIHNAQPDDSGVYCVRLGDAMFKVAQITISGEFGQQNLSGSRLRRISSQSLNRLEKDAQTKAKQKAKSPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRA2</accession>
    <name>A0A914GRA2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GRA2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10456.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10456.t1"/>
        <property type="gene ID" value="Gr19_v10_g10456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10456.t1"/>
        </source>
    </evidence>
    <sequence length="818" mass="92410" checksum="705562DA5FDF777E" modified="2023-02-22" version="1">MSNVNNVDRLMQELDVEQLIQFQSSLKKEMEKKREELRQMVGRRYRDVLEASNTVKRLCEIADELAALLADIRQNANEWKRDKNAGELPFSTNLAGTNVVPTLDRNHNAGRRFLLLQSLLSMCFTSNGLLTRAFALCLANNFHRTLSSESHSLSSFEAIVINMFSNQLIQIRMELQDVLTDKMGVNASWNAIVSTLVSYALLRPRTTVEELLQLFLKSRMDFMMTNLQQPDSTLLGLIRAMKDTVQCAEQIFGDGGALLSALQCVATKGWSPASVEQLVENQPLLTRQLLKAEIELVNSLYPFFQLPDQTEVQKQCSDWVVKMCEIVGERVRKMCSYFEQVDQAVEFAVAVGQLFKSNWSSVFASNSLIYRQLFGNALFDRFNELIAMELQQLEQQIRSKMPHTNCEPFPLFHKRSAKFDALLASGISHELNELIQQLSDSLRLLHQNINKYTLISQEENVEQLHEVLADQVLAFVDRLTNFSSWNIPDETTFQLSNALTSLSLASTSADGSSRSQWLALFRLLLALVQHEPSVLCQCMNRNVDKIVRCNRTLHKATEQALCRFMDFVIDDCVRVSNILVVMRKCCSSWDGWMELLQEPERVQLSETAILAVPTQLSQHFFLFLSTIYRAINQNSLGHLLTRTVTLHVSQRIGHLLSQLLCQCAEHSAPVPQICFIDASQRIEAKLDPIELSVLQEPISRNAKLFAQRTAMLFGQLQAEPITTLKDAELPSAYSQLIDITPRGADVQRLTQIPRLSKLKEESQKSVEEVAASIKQSKKQRKTKTGTAEVGGLGLPVKGAATSSFSSLYDKISTGWFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS60</accession>
    <name>A0A914GS60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10272.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10272.t1"/>
        <property type="gene ID" value="Gr19_v10_g10272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10272.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15098" checksum="62E5E97691CAE23E" modified="2023-02-22" version="1">MATSMFVKRLLANASCFGLLLLYVMLGGLLFLRFEREQSLRERDDLIRRKSECIRHFLRIEIAPDSNRSGSPTSSAERITEHCLFGIVDPTEGRRRQSWNYRNALLYGFGILTTLGKSRAYRIHFIIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSH6</accession>
    <name>A0A914GSH6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSH6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10801.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10801.t1"/>
        <property type="gene ID" value="Gr19_v10_g10801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10801.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19187" checksum="0C73E147F55B6495" modified="2023-02-22" version="1">MVPSEVSCTVTTKGPKQSGLCTLTLQGPNRSQLHAPQLRKAPSEVDCTLTSQGEAYAMFSTVATEAACLKPALFEALVDVRVDERVDEHLVLFPLLRPPVPSQPFPAVKEQQAGHNTAGDYTPCDLRGVRRNSECQHRHSTISALTTSKILVREHLTLAARRPVKKTVSGKGPSAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSV7</accession>
    <name>A0A914GSV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10903.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10903.t1"/>
        <property type="gene ID" value="Gr19_v10_g10903"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6913.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6913.t1"/>
        <property type="gene ID" value="Gr19_v10_g6913"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10903.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6913.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19673" checksum="8BBD9CFB08DC4867" modified="2023-02-22" version="1">MGRKKKKPQKPWCWYCNREFEDEKILIQHQKAKHFKCHICNKKLFTGPGLAIHCMQVHKESIDKIPGALPGRDNVNIEVYGMEGLPPESTRGYVDDEATDVPPSKIPRPAGPGIPLPGMMPPGHPMAAFNQFMPHAPAPYGMPPHGLLFVARCLEKKGNGVMGVIGSADRRRREKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU00</accession>
    <name>A0A914GU00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11220.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11220.t1"/>
        <property type="gene ID" value="Gr19_v10_g11220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11220.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8869" checksum="CA567A6302418028" modified="2023-02-22" version="1">MCSFSSSIPSKLTHPGALARANDGELVNDASQEETGSGSAVERLENDDDPETWNESDDDHERNVGRRDVNEFMNGKDMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUL0</accession>
    <name>A0A914GUL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1135.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1135.t1"/>
        <property type="gene ID" value="Gr19_v10_g1135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1135.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19500" checksum="6845DE30DADF80D2" modified="2023-02-22" version="1">MDPEDRKRRQDRNSSRTTRGTGCSMRRSTSKPQTSRTPSVRGRGRPKGSRSGVNKTRPASKKPARGRPRGSRVNKTRNKTTSTRRPASKKPARGRPKGSRVTKTRRDSTKTPAKKTTDTAVSVSSSNDSVSESKKKTDGASNRQSQAKKKAEEDNSSDSESPTQSGTESARTDDSAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUM5</accession>
    <name>A0A914GUM5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="AlphaFoldDB" id="A0A914GUM5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11360.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11360.t2"/>
        <property type="gene ID" value="Gr19_v10_g11360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="53"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="206"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11360.t2"/>
        </source>
    </evidence>
    <sequence length="647" mass="74385" checksum="83BD52A114D683B6" modified="2023-02-22" version="1">MRLSGVSYINCRLPFSSSAICNLTKQAETVGVRQKFVAKEAQILPMNGSTNRRVLCVAEKNDVAKNIAKLLSKAQARTENGVSKYNKNYTFEGISQSFVFTSVSGHLMNYDFHESHKQWNENRISELFEAQIILNVDSGMRDIETNLRAHTLLIWTDCDREGEHIGDQVVKVCRKENSHIIVRRARFSEITEQAIARALNNLLSINQNLVDAVDCRMELDLRIGAAFSRLQTLHIKKNFYQFFQDDRKSVLSYGSCQFPTLGFVVERYKENREFVSEEFWKLSGKDGNTNVGFLWEREGLSTQLFDREAVLAIYESCNAVIHSARVNELEKLGSRYLKMNVKRVVESAEKLYQRGFISYPRTETNCYSAEYDLDTIVTRLTQNNEWGHFARDEVQRRGGPRPRNGRKTDEAHPPIHPVKNANRSEMANMDEWKVYELICRYFLATVSRDASGRETKIKAKVNEEIFTATGLIIDDRGYLQVYPYDKWSDKELPVYQNGQSLPNFQIKMPNGFTQPSSLLTEADLIALMDNKGIGTDATHAEHIERIKFRKYVVLNCSSRFEPTKVGLALIDGYDKMGHRHKLSKPILRALLEEDLLLICEGKKSKQTVLREHLAMYKELFRYTEMNKHVLGESLCAVHQLNNHGLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVJ8</accession>
    <name>A0A914GVJ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVJ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10794.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10794.t1"/>
        <property type="gene ID" value="Gr19_v10_g10794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10794.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16078" checksum="B481A33A83949379" modified="2023-02-22" version="1">MADLRNDLAETPIVADLRNAHNGGFTKRPGGFTKRPKMANLRNAHSGGIYETPIMADLRNDLADLRNAHNGGFTKRPGGFTKRPKMANLRNAHSGGIYETPIVAEFTKRPSTLSTVDSPDEIGGRGKMGRMPGPWALVMDSSNSPIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWC7</accession>
    <name>A0A914GWC7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWC7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11007.t5">
        <property type="protein sequence ID" value="Gr19_v10_g11007.t5"/>
        <property type="gene ID" value="Gr19_v10_g11007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11007.t5"/>
        </source>
    </evidence>
    <sequence length="485" mass="55214" checksum="D392DC555A82AE63" modified="2023-02-22" version="1">MARPKDCGSIWNQPTKGNSRQESILNFTVPKKNSVEEAEEQIARIMIRQNNSFYFFEDNDLKSLYARAYPNLPALGCRKHFRCNVLPRMANDVCSRIKSGVLNSFYAITSDGWSQPTKSPQLQSVTIHWIDNNFGRNDNVLASFPMDEFRHTETTQPTSAERLQKTTLCQFQRAGTQYFGCCQHFWSKKRLVGMETIPTNLPRIDAMDFDCLRHVCPILRVFDVETQKFSREKSTASVVLPTLKKMSDFLIQANIPTTLEPFVNKLIDSISDRVRKLIGNNLLRISTLLDPRFAYDETIFSKTNWALIEQDLIEFGKKVYKENEGRDDENDFQPLGFLDETDLSAGEKSDESVRYDIWKPKSPGTISVPSTLSGELQTNLTTRIQLQLASFKAFGRPSIDADIFNWWGSNVPATSVSSERLFSKAGLIFSNTLRNRLSAKTVEKILVVKANLDELHLAPSAEPDPEKGDDDETIDVEDNEEDDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXG1</accession>
    <name>A0A914GXG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11284.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11284.t1"/>
        <property type="gene ID" value="Gr19_v10_g11284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11284.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10219" checksum="3ACC52D1F2A76E3A" modified="2023-02-22" version="1">MSVVAGRKVLIDPYEWPRVLAALKAQRPPTDSWNYDPPWYDNILIRDEGMHKRMSSTDGGEREDGSMGKRLFVARIGKRMAHGYWARVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY25</accession>
    <name>A0A914GY25_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="AlphaFoldDB" id="A0A914GY25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11836.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11836.t1"/>
        <property type="gene ID" value="Gr19_v10_g11836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000002">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="174"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="769"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11836.t1"/>
        </source>
    </evidence>
    <sequence length="794" mass="89731" checksum="5664626D1201ADB2" modified="2023-02-22" version="1">MNVLMVAEKPIVAEEIAKILSNRKCSTRKEWNGCSVFEYTADFRGEPANFRVTSTFGHMMCVDFPKHYQRRFSGNCVDPAELFLCPIEQKETDPDTNMRDFLASEAKNCDILVLWLDCDKEGENICFEVMDAVRHAMNGPSGGVGFMKNVYRARFSAITEKEIKNAMTSLARPNIDESLAVDARQELDLRIGCAFTRFQNDYFKRKYRDLDSKLISFGPCQTPTLAFCVERHDEIVNFKPQPYWLLQAEVELPGGGGGMCRTLKLEWCRERQLNRGVAQTFLNKVKKCTEATVSDVSSKEHRKEKPDALNTVELLKGCSSSLGLSPSQTMAVAQYVYSKGYISYPRTETTAYPDSFDFDVALRELKNMPEFREFVYQLLSDGISKPEYGINKGDHPPITPKRVPPKRVPPKRVPAEFDKNCARVHEYIVQHFLATLMQPCKYLTKTVKFDIGGEQFQFQCRVVTDPGFTRVLNWLAVAQDQTMADNAPIVGQRIAIKKVDMIERMTAPPDYLTESELISLMEKYAIGTDGSIPTHINNICVRNYVKVEPNRRKLMPTTLGISLVHGYQRVDSDLILPTMRADVERQLDLIAKGKADYATMKNQTLEVFRQKFLYFVKNISSVDELFGVSFTTLADSGKPFSKCGKCRRYMKIMETGPQQLFCPICQDTYALPSSKGSAIRQHFERACPLDEFELLYYHVPGGKLSNSFPFCPYCFNHPTLEEMRGKQLGCNQCPQPDCPNLYKTQGVLPCMNQCFGGRGVLRGLELQMTARGRGGRGRGGGGRGRGDGRGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYL0</accession>
    <name>A0A914GYL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11980.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11980.t1"/>
        <property type="gene ID" value="Gr19_v10_g11980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11980.t1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32494" checksum="46C2DD18F5B672B5" modified="2023-02-22" version="1">MDKVQTKLRIRNELGRALLGEFLGTFLLVLIIGCVCAQAILPKPTLNQTIGINVGVGLGIAFGVAVCAKVSGGHINPAVSLMFLSFKQLAPLRFVLYSLVQLAGAFFGAAVAYLVYKDAINKFDGGTRQVYGTKATAHIFASYSGAHLGVFNGFIDQIVATAVFCLAIAHITDKRNHYPSYLQPFLVGTSFVMVGTAFAYNAGYPCNPARDFGPRLFTLLVGYGWEVFSYNDYCWFWIPLLAPFIGALLGAWIYQFFIGIHVPADEQYEIVTTTITTSTKQQGELQPLAPAKEHNEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYR8</accession>
    <name>A0A914GYR8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYR8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12576.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12576.t1"/>
        <property type="gene ID" value="Gr19_v10_g12576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="91"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="366"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12576.t1"/>
        </source>
    </evidence>
    <sequence length="586" mass="66652" checksum="D5380C0A51298D1C" modified="2023-02-22" version="1">MLDRFIRNFLNGQQIIHKIRHVQTVRLTFLHKCIKNECPAVLSWDTRMASTSSSRPSQSSKLLNDYRNNRIANLQLADLGNDVLEFARDPLGSRFIQQKLEGANPTETAHLMDALRGHVLTLALHINGCHVIRKALESVDRMSQIEIGNELSAQVLSLSRHKFGSLVIRCVLDHCTEHQKRPMLEQLLGNVLTLVMDQYGNFVIQHVIEHGLPEDRERIVRSLHENVLTLVMDQYGNFVIQHLIVHGLHEDRESIVRSLHENITSLSLHECGCRVIERLLEHCTEHQKRPMLEQLLGNVLTLVTDKYGSLVIRHVIEHGLPEDRERIVRSLHENVLTLVMDQYGCYVIEHLIVHGLPEDRERIVRSLHENITSMSVHKYGSLVIRCVLDNCTEHQKRPVLEQLLGNVLSLATDTYGSHVIRHVIEHGLPEDRESIVRSLHANVSTLVTDKFGSYVIEHVIVHGLPEDRERIVRSLQGNIIMNNGHLNSFCNVIHKCFIFGTMEQRNALIDEFCADNGSGSPPLLEMMKHPFGNKVVQKMMDVADSARRQKILLAIKTAPLKNTAKRSSESLTTVKVQQQRGGTEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0Y4</accession>
    <name>A0A914H0Y4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0Y4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12618.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12618.t1"/>
        <property type="gene ID" value="Gr19_v10_g12618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12618.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17565" checksum="67FE1BB39DF19116" modified="2023-02-22" version="1">MFAVGSRIQMHAKRRQSVAAGGGALRKTEALHRQVLLVKRGLHLSNSVPLDNPKSAVVGNGTIMSKQLQQQQQQQGSLDLPSIVLHLTGRDSLSNSVATPPPTDGMGSPFRGRRRAVDISAHKACALLMARMKEQRGADGAIMSSQRTAPTTLSVGFVRGIYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1D8</accession>
    <name>A0A914H1D8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12755.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12755.t1"/>
        <property type="gene ID" value="Gr19_v10_g12755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037311190" description="Kinesin light chain" evidence="13">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12755.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33691" checksum="773EF31EC7E99A12" modified="2023-02-22" version="1">MPFLFFGLSLIKTMWGGGVKINITKHRPSCSVHPPILQHQSPTICGHRVDERICRIDQITTKIKRARCKRAKLTLRRNLALGQMKTIITCTVLQYAAQGNYAVAVPLCKQAVKEQEKHKGHDHPDVATMLTILGLVYRDQRKYREAVALMNEALAIRERCLGKDHLAVAATLNNLAVLYVKRGKFKEAEPLCKRALEIREKALGHDHPDVAKCGWQSKRPTRGGTFVQTNSDTGARTSIRAHGHRRCGRADESGQGLEQATPRAEMAAVKAPHAAQRDDNSNIEQEGSNEKAIIDWVNNSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H294</accession>
    <name>A0A914H294_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914H294"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13464.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13464.t1"/>
        <property type="gene ID" value="Gr19_v10_g13464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF492">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13464.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33945" checksum="9F6F1D4B7467F35F" modified="2023-02-22" version="1">MTGPLSISQVEGIIEKVRQSAYQNFTESVSVDEVHFLCETALNVLRLEPSLVEIRPPVIICGDIHGHFTDLMRIFTRVGHPPDRNFVFLGNYVDRGKQSLETAVLLFCYKIKYPETFILLRGNHESSAINRSNGLFEEIGQRYGQQHAQLLWKHFNQAFAWLPYVGLVGKRILCVHAGLSPSLQSMDQLRKLRRPVADPPNPSLELDILWADAEPGIQGFRANTRGASVMFGEDVVANVRKLLDVSLIVRSHQPVKNGAEVFAENRLITIFSASNYAGHGNSGAVLVVDASMNYTTEFFPPIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2J8</accession>
    <name>A0A914H2J8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2J8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12650.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12650.t1"/>
        <property type="gene ID" value="Gr19_v10_g12650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037159005" evidence="2">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12650.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29539" checksum="07C3DCBE67BEFA5B" modified="2023-02-22" version="1">MDLFFYFNLIIFLLLHICSGGTCSCHNTLSYYGKDFNPRRADFCWKSTGCVESTCTYENEQKIWTKVSKGCTLDANGTCPRLKKRCLTDGGIPSADCSYCTGYKCNDKISPEIVWCWNGTVNDDKQAFTELKCEDASCYSLLCVGAENSMLFQSKGCLTLSKLWEMKLPFVEFGQTACKALNGTISRKLCDGTWCNAEQGQTEPGHTEPGHTEPGHTEPGHTEPGHTEPGHTEPGHTEPSQHGVRVFFAVPSLTLDTIVVLLLLMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3Q3</accession>
    <name>A0A914H3Q3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum-Golgi intermediate compartment protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3Q3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13365.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13365.t1"/>
        <property type="gene ID" value="Gr19_v10_g13365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="9">
        <location>
            <begin position="148"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13365.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41295" checksum="52940ACFB07B4009" modified="2023-02-22" version="1">MFLHRLRRFDLYTKPVEDCRVKTPFGGIITLISFVVIILLFITETWSYLSVDVIEQLFVDSTSAEMRIEIHFDITLHKLSCPLVTIDVMSQSGESQDGIQDDVFKQRLDSQGNIIEGAKPEKQVVNTNTSKSANVSRRASSDEECGSCYGAINGCCNTCEEVREAYRLRGWVLQNIDKIEQCKNDAVLRSLSEQAGEGCRVWGKVDVGKVGGNFHIAPGVPSTHANSHFHDFHSVSPARFDASHTINHLSFGKPFPGKMHPLDGKQFITNKGGIMHQYQLKIVPTRHQFAITRVERDIMAGASGIPGLFVQYEFSPLMVQYEERKRPLSFFLVSLCAIIGGVHTVAALLDATLYNTQRAIQRKMAVAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3U1</accession>
    <name>A0A914H3U1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent RNA helicase DHX34</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3U1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13591.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13591.t1"/>
        <property type="gene ID" value="Gr19_v10_g13591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004714">
        <property type="entry name" value="DEAD/DEAH box helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000725">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF221">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="164"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="363"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13591.t1"/>
        </source>
    </evidence>
    <sequence length="1069" mass="121742" checksum="B40200992139C282" modified="2023-02-22" version="1">MADWVEYRPQLLRAYFASSSPIAPPESAFHKEFLAFLSRCEAKVVSASNASVKKKLDQHPLTAFGAAVAEGVDGCGGGAAVPCNSNGVPEGPYCKYFASNIQLTDKAVDRFQLMRNVPAEAVRQFEHIIALYQRFRNAKNFKKLKKLKQSQLSLPIYQSREEILTKLAENQIVVIAGDTGCGKSTQLPQYLLNAGYVKIACTQPRRIACTALAQRVACEMLKQFDSHIAYQTRFDKTKTSATRMLFLTEGVLLRQMVDDPGLQRYDVLILDEVHERNISGDLLVALLRSACQRRTDLKLILMSATINIELFQHFFPEAPVISVPGRLYPIEQRYMPPLIRELDPTAKKAVRIDPGPYVNILQLIDKKYPSTERGDVLVFLNGISEISIVADACKEFAEFTKRWIVLILHSTLSVEEQQKVFDLAPMGVRKCILSTNIAETSVTIDEIRFVIDSGKENLMRYDPSIRTHRLTESWIAKASADQRKGRAGRTGPGVCFRLYSEEEFTKMEDFTLPEIKRVALDSLVIQILDMNLHIDVRDFPFLERPDMRPLNETLEALKAQGVVDSRNEKTLTPLGIILAKLPVDVAISKMLIYACVLNQLDIALTIAASLSVQSPFTNRSFRDADCIQGRQHLLSDMGCPFTLIRVYREWLRVRHEGVEDTRRWTRRLGIEEARLYEITKLRRQFREILEQNELVPRREEREWAALSSRERRLLVGEKRKLFELKKRAGHEGKRTKVLREGQHFDTIMERNREEESHLLANAQEQIQHLEFSLVTGGKGMERELGSHRLDDNIATELKLVLAAGLYPQYGVLDPTNNFREGHDQFAHTPSKPFVVLHPNSALGQRPDVLRLDDLDSEAHSAQHQLIYFGLLLETTKPYLCNSCRIPATFLLVIARNITCVSPCVLCCDGFVEFHFLKARHCDHSLEFACRVRSLFLQSVEHKLRSDDYGDCRELERLIIKFARLQHPFSIRRRIDPPKSMEYGVFTADGMQHPLSASLVVSSADGFDGAGDEEDAELDAQLDKRRAEEEQQQQQQKGREYFCDVCACTLWFADNVQAIKHKKGHQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3V7</accession>
    <name>A0A914H3V7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3V7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13752.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13752.t2"/>
        <property type="gene ID" value="Gr19_v10_g13752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000481">
        <property type="entry name" value="Asator, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000358">
        <property type="entry name" value="Tau tubulin kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13752.t2"/>
        </source>
    </evidence>
    <sequence length="860" mass="94307" checksum="F173D83E4BDB7E68" modified="2023-02-22" version="1">MTSSSECEILQPSQIIRERWKIKQKIGGGGFGEIYEAIDTQNHNERVAIKVESSKANKQVLKMEVAVLRRLQGKKHACKFYGCGRNDKFNYLVMGLQGKNLADLRRESPSQRFSSSTALRVAYQLLQSIRDIHSIGFLHRDVKPSNFAVGRTLPTQHCIYMLDFGLARLFLNAKGEVRSPRSAAGFRGTVRYAALSAHKNKEMGRQDDLWSLFYMMVEFLNGSLPWRRIKDKDEVGRMKEEADIRELLEGNPPELHHFADHLKGLSYPDAPDYELLENCLLVAMKRLGIGIKDTFDWENNYVNIHDNRHPIGFQAVDGKMSSKIGRSHTTALREHGPAGEKANRGLDTQAPVTDEQMTREECDEQTGNLCCPPNLAHNDSSHEKDEAKPKYKRQEFMRPKINQQQINQNLQSGAAAINAVNERFKKVHSSSPVPVGSRRYQNGSKLSSPASNLSEDRHLQRHQQKQMASAQHSPSLAQRTANGTLPNGTAKEFGDQHKNFCGSMPHLPTASSKHTNEGGYSPSTLFSPVKTNNNATGKVPFPNAVRKLKSSDNMVVSGGEFSPSKSPSTPLLSQRQQQARHNGSRERLNKYPSADSSPIYQQQQRIEDYHQQQKYVTTTPTTGAIGGGGGGKASSRRASRDSGELIGGANLISHFKNLVQSFNSLSMSTKHGRSKSLSRGLSSVPVANAAAGVNERKQHGGPMVLMPSLQKVPQGHSKLTTPGSNNNNNNNNEDTSATSGIGSASPTIRNKSREGTIAGASMDCCSEEHLRDARQRSRRRDQSAGSSSRHTAGVVIARGAGGVANAAGKNNALSAGGGGVGAAARQYELEMLRTLGQKQQQSRAAPTILLKHNGRYVGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4E9</accession>
    <name>A0A914H4E9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4E9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13546.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13546.t2"/>
        <property type="gene ID" value="Gr19_v10_g13546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13546.t2"/>
        </source>
    </evidence>
    <sequence length="409" mass="47298" checksum="83746772B9EF1AAB" modified="2023-02-22" version="1">MFKYRRLREEKEEVMGMDEREEEGLDLAGPSSSSPKSRSPRSSSSRLSHSQQQQKAEEFHSQFSEEDFQLELRQFGAKVLGPGGVSLPRRSELWRLLDSGEDAISVMCFTWNIAGKAACSLPQLNSLFTNMCPRERPSLIALALQEVPPSTLKFHASVVQQIGHSLDSTHRVFCWVRKWSQMLVIFVRHRLALFTSHPEYRFVAGANIARPFRTKGAIGICFRLLQCHCVFIACHLTHGKVDCRILDYHKMVRSFNFNWRPRTNGDEYANVFWFGDLNFRVHRVADVEKIARSFEQKTFWRPSDFVHILAHDELSAERQKGLFEGFCEGIIRFPPTHKFLIGTNLYVPNRMPSYTDRVLFRSLSSDSSQYLVPIRYDCVWDVTCSDHKPVYCTFRMSVVRKKKGQVENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5F9</accession>
    <name>A0A914H5F9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Macoilin</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Rough endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5F9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13842.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13842.t1"/>
        <property type="gene ID" value="Gr19_v10_g13842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019130">
        <property type="entry name" value="Macoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289:SF6">
        <property type="entry name" value="MACOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09726">
        <property type="entry name" value="Macoilin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="763"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="793"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13842.t1"/>
        </source>
    </evidence>
    <sequence length="905" mass="101714" checksum="F945471B4D88E454" modified="2023-02-22" version="1">MKRYRAVDVPPKFRRTAKGRNTRLGDSVYFNRFFSAYNLVYLKFFLMWFGCSFATFTNPSVSTLFPLLFIIQLSLFFSCALRQRPISTYVWVQFVYQSSDRGVCLPSLFLWALFIVFEYSVRYRFDNATWYLTRTSWITAGLFPSTADSVSIGLSGGSSSSSASPSSTRLELYRPFAAHCIGFPVVTLGFRVKSFFSNWRMRVRREEVMRQNEFFERLLADAIPTSFESRKHFISSRSHLSIDQDVFDYDAVYSTSDLLNGFEANSQQPRLYSVLNSSSSIAAICAPPSCGNSSSSLSQQYSSTSNAKKHSKSLSKTQMSATKQNGTAKRNELTPLKSSGWRPETNGANVFGKKALGEKRNSMHSIVPNVSSGVNRCESIFLKIWRIVVRFFCQALEGVLAQLRVSPTQQQDDMVSTSGEGSNVADEEEWEHESVHFQSAYTDHHGSRKKSRRARGLSSVSQTSAAPNEPGTYTSSALINAQKMASAISNSSTALPSASMHKLSADLNDIGHASSLSSGVGQQHQETDNSDCSLLRENAQKLSEIRQLQKERQTLELSLDKLKVELKSARTGDHELRSQLSHAQRQEQSCREEWKQFEREQKQKVEQLESKCKQLSKQNDYYKLNTQALERRLGEMQLKKNSRDDPLGKQQQNASDNGELKQKFATQDREMKTLRKDVKTKNEQCTKLEDELRQLRSTKNDGSKQMEMMRQKNFLLEQTLSSENKLKQDLFRALNDSKAEVALLKARLHTKQTKEQEDMMSAFRETTASSSTSNSLFHGNGGTFGGSSSGSSPTAQQQRQFPISQRKSLTPPPLSVGSSTFNSALEQLLQATQNMSYSLSPLDSNGGVNTTAARLRTSELRRRKCLQSADIVRPPAQTLAVLQRKGTAIEHWREATGTVMTAIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5T8</accession>
    <name>A0A914H5T8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Golgi SNAP receptor complex member 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 10">Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">cis-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the GOSR2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5T8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13943.t4">
        <property type="protein sequence ID" value="Gr19_v10_g13943.t4"/>
        <property type="gene ID" value="Gr19_v10_g13943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13943.t4"/>
        </source>
    </evidence>
    <sequence length="213" mass="25444" checksum="075AF8E3D709294D" modified="2023-02-22" version="1">MEQLFQQANIDLHQIHLQMRQLELCKNESEAQPIFQMLHQRIRQSADQLENLERLVNKEPSAKRHTSKYRYEQLRHDYNALETAINSLQNRLTTKWRTAAEREELLTMRFKPNETHLDFEGTELLVNDRLKQSHSAVDDLISEGNSMLTSLRHQHLGLKGMKRKMLDIGQMLGLSSTTLKMIEKRLEEDWLLFLLLCFLFLVFMYCFYRYWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H611</accession>
    <name>A0A914H611_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H611"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14508.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14508.t1"/>
        <property type="gene ID" value="Gr19_v10_g14508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14508.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13378" checksum="45B5D8C5428CDA45" modified="2023-02-22" version="1">MPVFAEQAHNAKMVLEFGIGVGLSKFSIDTQTVFNGLKELLDNQKYTRRVGQLQGIFLDRPMEALDEANFRLSRIIRRSKSEESGRRERDFFKRKRTLLGAAELTGVCDSKRQKGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6A1</accession>
    <name>A0A914H6A1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Caspase family p20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H6A1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1408.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1408.t1"/>
        <property type="gene ID" value="Gr19_v10_g1408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="8">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="7">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1408.t1"/>
        </source>
    </evidence>
    <sequence length="568" mass="64811" checksum="146A44C964F09B29" modified="2023-02-22" version="1">MSGARGRKQKTQQTRRHHSESDESGSSSSELEYGSDFTYSGLLERIKKGAKRLFFKKNDEDRIGRRLYPNTVSPRGMALIIENVNFVRLSQRTGSWADSSKMRRLLAEMDYTVIFKRNLSAQEMMDAVTRFARRPEYEEAQSCVVCDEPWALRRHRRFRRQLRGSARVCRPAEWSALLAADQQTENILRDQGARVRESVGAIAGTFGTRHRRDSPRRSTSRDRQQSRQILARVPSNQEMLLAMSTAPHHVWVRNPRKGTWFLHSGSIDKAEFVAGFEETLCKGESRGFNGMQRKISTTEYFEDEDQQEVHKPALVRMLFFPIAARPLPFSVPLLVLFRAGLFVLPASVPCRLLLLRPSPVFSSGPLFHLRLYLVQSRHLALHRLHVGKCRAEYLLQHLRVCSELRARNVFRERNLPLARARVLPRPYAFHEDDCRQLDFEHFQWGLCRRVRPAPGSRPLLPPPLRTARLLRFPIAEPVHFVLLALVHLLHRRLRPKCAALRPGSTGKQRAPLVTCPVSDRFFPPTALSALRFPLSTLSLLGVPAFEGVVRGGGGSIGFVVGCPLVAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6Y3</accession>
    <name>A0A914H6Y3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H6Y3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14760.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14760.t1"/>
        <property type="gene ID" value="Gr19_v10_g14760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="9">
        <location>
            <begin position="61"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="220"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14760.t1"/>
        </source>
    </evidence>
    <sequence length="454" mass="50916" checksum="65D1847708C1474B" modified="2023-02-22" version="1">MIKHSLAPDAGAASLNSRRAHFRIAMVSDFFCPNTGGVETHIYQLSKCLLRNGHKVIVLTHAYGPRKGVRYLCNGTLKVYYLPGLVVGNIYLPSMLGSLVWFRRIFIREQIQIVHCHSTFSTMAHEALLHAWTIRAGIRTVFTDHSMFGFAEANAVLMNKFMLRYSLANADRLICVSHTSKENTVLRAGVAPQRVFVIPNAIDAVLFQPDPARFARPTVTTVVVLSRLVYRKGADLLVEVIPHICERHPTVQFLIGGDGPKRVDIEEMRERYRLHERVKMLGTIPHDTVRDALVQGQIFLNTSLTEAFCMAIVEAASCGLHIVSTRVGGIPEVLPPEFISLVEPNPKEIANALLDAIRCREKGQLPCPLKKHRQVAKLYHWEDIARRTERVYAESLGEPEGGVGQKLRNQLSAGFWFGLVWTSATAMNILFASLLDWLDPREGIQTVDDKKKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7J3</accession>
    <name>A0A914H7J3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7J3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14931.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14931.t1"/>
        <property type="gene ID" value="Gr19_v10_g14931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14931.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15710" checksum="0328F55C8E10293B" modified="2023-02-22" version="1">MSFRSGCVGEIRWHFAFALTLQLCIGIDRLIGVIFPIWYKAKGKNITFKCAIGICCIRSLLNGFNAYIGTSAHWEKPVMCILGDPNQQPENQYFSNISALALLCNRLHTEAMLRFSTFAVPNIAALFAHNLVINQTKSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8L5</accession>
    <name>A0A914H8L5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8L5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1475.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1475.t2"/>
        <property type="gene ID" value="Gr19_v10_g1475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1475.t2"/>
        </source>
    </evidence>
    <sequence length="630" mass="72926" checksum="57E89AD577EA6830" modified="2023-02-22" version="1">MLTPQNGDGRLEFTQTFCRDCAKLNFDCTDLIMKHQKKDAPTKNGHYHPYTGGNNTPGFVGNKTNKFKVHLPKKLVFEGPGWMVGMSGIIYPNSWATVGTLEKQYVIVHLRDGRKYRFKVPRGSFLSPQQLERGIHHGMIAEMERLMTRKRAAFQEDEEEEGELVDVQVVEEEEGGLTGLQVAKEERKESVEAPLLPMSQTKFASEQAAERTRQPPLANVRPPEQRGAVRERELVPPNETERLAQEKENERKRKAQKWIEDGRKETERRRQEALRKETERLQRMTNATKEGATSKKKEEEKLGTPKQAPQQAVNEMLEKQKEEERLPKQKEDPGKKEEDRLAKQKEETEKKEEESSAKQPEDVGNRPNNGIERAVNPAGEEERIRRDQERKFKLRELELLKELKPYRGGWMRLVQGKDPTPDVHYLHEKDEYHFSNAVDKYRIHHPELAWDLPEFNPSAQIQRNIAEFKGLFEREVYDENYGSKTREEKEELIALVKGFRFYYMEDIGRFMLKIFDNKISHITLTDQLAYVLGYEQEQQILNEDLAKYSVDLGGGVSHLCIYLNSGIIESMIFGNTFANLLQVIAVEGKSGSVVEKDFQSPLFHKIIAREVDVLDVEIRTLTGRYVYAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9K5</accession>
    <name>A0A914H9K5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9K5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15052.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15052.t1"/>
        <property type="gene ID" value="Gr19_v10_g15052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038068924" evidence="2">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15052.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22415" checksum="EE82084FEDFAB6F1" modified="2023-02-22" version="1">MEEFWILILILFFVTNSLDKAESVKVKLEETPLKTFDEIFGEGWWDKDEAEDLKSPPTNFGQNVHHQIDRQNTQIGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQNPPLTKSDHSDNAKNGEEQNEISSNEKHKIIDKFHAMKDEFKQKGKYSAKERVQIEDKIAKHLKSIAQKYLNGKKNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9N4</accession>
    <name>A0A914H9N4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9N4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15331.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15331.t1"/>
        <property type="gene ID" value="Gr19_v10_g15331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15331.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24509" checksum="2060D529FAED1DCE" modified="2023-02-22" version="1">MSIFCVNYLASFQIDAASLASDLAVLQRQHLLLCIAFPQSSLFAPFLSDHSRRLRKTPIDPIPLCLPKFPADDSAGASSAQALAKWLHTPRGDGLPKVMKCGEFCSTGMAGLQMEFVNSVVSVNFIIIVVDERFGFVPFELKNTLTDERLVSRRFDEHKWLFVRCPIERDEAKWAELENEAIEWNWNRWNSVDICFNDSGIDDGLLDENEGPSEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9Z7</accession>
    <name>A0A914H9Z7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H9Z7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14635.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14635.t1"/>
        <property type="gene ID" value="Gr19_v10_g14635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000044">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036675074" evidence="5">
        <location>
            <begin position="26"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="137"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="317"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14635.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="45813" checksum="9293EBC546D7B08D" modified="2023-02-22" version="1">MGRKFATVLALFSLIALLGIGAASGHHLQHGQQAAKVPLRRMDTLRTRLAAAGSLEQYQKHFHKSLRQRWERRFSNSKLSRVSTAFDADARVGTDAVLHNYMDTQYYGEISIGLPPQNFTVLFDTGSSNFWVPSKKCPIKDKACFLHHKYDSSKSSSYQPDGRRMFYNLSPRTVEAGLKTAKFDGILGMAFPEASVRNLSTVFDNMVTQQKVQEPVFSFWLNRNPASKLGGEITFGGTDQQRFVAPITYTPVTRKAYWQFKMDSISGSQGKIVCQNGCQAIADTGASVIVGPKNEVAEIQNYIGAIPDINGGYTVPCEEIPTLPDVSFNIGGKAYTLKGNDYVLKVTTKGKTICFSGFMGMNLPGFANLWILGDVFIGRYYTVFDVRQSRIGFAQAKDENRAPVEPAVRDFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA58</accession>
    <name>A0A914HA58_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g15638.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15638.t1"/>
        <property type="gene ID" value="Gr19_v10_g15638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="FHA_TCF19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042803">
        <property type="entry name" value="TCF19"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15464">
        <property type="entry name" value="TRANSCRIPTION FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15464:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="721"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="859"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1552"/>
        </location>
    </feature>
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        <location>
            <begin position="1615"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="929"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="962"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1011"/>
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        </location>
    </feature>
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        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
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        <location>
            <begin position="1101"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1187"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1208"/>
            <end position="1221"/>
        </location>
    </feature>
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        <location>
            <begin position="1222"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1242"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1271"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1284"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1323"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1340"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1354"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1398"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1443"/>
            <end position="1455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15638.t1"/>
        </source>
    </evidence>
    <sequence length="1640" mass="173186" checksum="4A1D7CA39EE842CB" modified="2023-02-22" version="1">MVESILLTMFHLRRVQFQAYVKEAKGRPVVESINDATEPSGIPAVRERSTMILLDKQTKIGRNPELVDVVLHSVVHSNMISRDHSEIVGETDGKGQFVRYYISDRSLNGTYVNDTRVKENVLLREGDLIKFGHVNGAAIKPGEHAPQHTAEFIFRFERSLPNFAYFGYSQKGARVHQHQSEHPQLQRRAYMQINSDRVLPTEVYASLAAAAAAAGASATGVGGGHGTVPRPIVSGCPAAVNSSSSATSGVTTAATSTSAPAAAHSSTAASFHPLHHSSSSASNNNTTTAASVNPSGCANASTNNNGAQLAHLAAVAAATTLANTVAAAAVATNGTAQQQRNQANGGTIDAATTSAASTLNALNQLGLTSATEEQVAAVNAHLRQLMASHDAMSAMERLAAQQQWNNSLLKLSSLQQQNPLVYGHAFPAAAAAAAALFTGCIDLNSAAANNPNSAAAQYAASLWPSIRALQPSVSQSADWAQQQKAAAFAQQLQLRLPGLYQQQQQQQQVANVVQHRGSSVTLPNAAPSLFGTPSAFSLPGSHTNSAATLLPSSSAGLLIAAQQQCVSTSSSTAYASCTSSATSAVGIPPMRHPGESPISSLSRGTSSVSLSLHPAQGTSVVDQQQNSTVALAARLAAAQQLAKELEADQHAKNSNNSIPGWSMGISCSSAAGSSVPVTKVSPLIGSSNGGGAADAGLGGATTPLQRIPGIASALAAAVVAAQQQHQQHNMPPWPSGTPPNNGLHPPLDTPPIRQPLAQRIFSPAVSNSSNLSLSSGSSKSSSGVSSAPSSGLLQSPGTCGGGAAIGALNNSDVGKEFRDSFSSLLTTNCSSTSAFSSPQTANNTNLNTLTTAMFAAEREKVNASRHRTTTSNNSALDEVVVAKVMTDDEKELAEGEQNEAPQKTTTPPPPAEWEKSDRELCNQQQQRQSLLIDQKTSLNGFSSSMSSDLDQLRMETSGSKMNNDDDHEDPRKADEMASCEEKREQMECDSSVPSPPPGREQQQQQQQLNLLEKESTGEDCKTQREKADLPAELSSLRKRHSSAGSSLSPTDESIDAGGDGGKAEKEKSGSTKPRPIKQARKSNEVARLLNDLTAGNCTDGLGKRGAKESESSRKKGEKRQYLMEWKTFDSDEEESAAEHWQNHFGREEFCRNEQYFGENRRKTNSEGSWQYMAERSQKLAAKQTNGSSGGGKSGGGRGDGADSPAAETTEKGGRMGMEKVQHQQQQQQLSSQSARTERKRPLRLEERKRAEIERKRAHKMMRQISDESSDEEHNGGGGGKRENVPNNGNSVGQNVQKQQQRHNNISKNIASPHLSSSDEDDDGGRKSPDLDSNDSDHQHQRQRHANSSRRRRKGSGDAKGKEHSPAKALTNGGTVPKRKLLSSAPGTKKAATMAPMNSVPTTTTTKLANGGPKNSEVPRKRGPKGGAEEKVKAAAVRSLKPKTNAVVVATSTALALKKKAGRKTGNGRGRPAGNLQKAADGTSETGDSSDDDSSVDQPVRLSNGSRGPMLNGGGPTLIREETRTKGRHRGRRRDESSPDLATTTVAEDWTGGSGDPELCAHKGCQRPLHMAINWVQCDDCDQWFHSTCVFGTNKTPDGDVDFHCGCGGTDCNNSTKTSTDNNKVANNAKSSSTASISSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAA8</accession>
    <name>A0A914HAA8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAA8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15671.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15671.t2"/>
        <property type="gene ID" value="Gr19_v10_g15671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15671.t2"/>
        </source>
    </evidence>
    <sequence length="95" mass="10343" checksum="D898B1C387B881A1" modified="2023-02-22" version="1">MMYQYSTARQGLVKSELMAVPLSLGFSPLYLAAREGHLEVCKLLIAKGADTNQKTNNGVSPWLIACGKGRADIVQLFLANGQDIEATGRISHTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBJ1</accession>
    <name>A0A914HBJ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBJ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15083.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15083.t1"/>
        <property type="gene ID" value="Gr19_v10_g15083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15083.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21412" checksum="A00947BC8A0482B1" modified="2023-02-22" version="1">MGHQGSAANFPCVLCHAKKGELGASSVGPRTLEGIRDDAQFRRHSIASPQFLDIAPTNIVPPTLHILMGIGQRILDYVERVAGEDGRASQLEQWLKTKHCRRDPRSRNYTGNAIKGLLSDPSPEELACFLPAGELRDVLLQLMSGLRIVYSLSKARMLDEEGLSKLEEWTKTSKISTPIPDENDPPRGRRMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBW5</accession>
    <name>A0A914HBW5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBW5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15178.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15178.t2"/>
        <property type="gene ID" value="Gr19_v10_g15178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="251"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15178.t2"/>
        </source>
    </evidence>
    <sequence length="498" mass="56688" checksum="87F1BFEF56D6AB80" modified="2023-02-22" version="1">MDSTAAAELRRRVDQEVLLCPFILSGLGGDRKQHQKVMKRVMQLVEQKGVESELLDLVCLKAILHEVNRQKKNESETLFKLENVVEWRRSIVEDRRRTSHHLVDSVGQSPWDKLSFDAYRQRFELIRMLVVQDVKHFDPIDSLLAHRGSKVCILAQLFRGTDGHFVAEDLSGCVRLHLGASTYEDGLYFEGGTYVFDGICSPDGNRLDVDQVTLPPVKQLSLCEAAVDGGERCAMRAELGRGSRGDPNDRIVLMSDVYLDDDRVMKALYHLLQGFSSSPPNIFVFCGRFISIQRAHGYMDQAAIAFRHFANILSEFSDKYCNTEFVLVPSADDAPPLQIFPRPSLLPVLQKCFKDAKNVHFAPNPCKLIFKDRHIVIYRDDMVEKLCRSAVFMPKNAKPSSIPKLFCDTIWAQRHFSPLPLFTNPIQPHFDPLFQLFPAPDALVIADRFNAFVESANDQRQLTLNPGPFSLGTHFEFQVYYPTLQRVEHSAYHEENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCT7</accession>
    <name>A0A914HCT7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCT7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15931.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15931.t1"/>
        <property type="gene ID" value="Gr19_v10_g15931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15931.t1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44459" checksum="EA5166459352916A" modified="2023-02-22" version="1">MVSEGIKYFERAIELDPYDDLAHFYCAVEYANSRNLEMAKECCQTALNLNMENPFAIMLMALLFTARKDFKGALQLAINALSDFPTHYGLLVLRLKLESKYGRVEEALQTSRNLIYFWRKARPPECFSPDDDNSGENGGVEVASRIGDSTLTLGGKQNNNSRDAMTPLTPLLAASIGIATPSAHLSILATSNCDAMTSSLNETTAAQLSEVGAPPSTDSLSNVTSSSKSWISFSAFRIQADIWVELAEFFIEIERVQDVQACVEEACTIYPHSHQALYLKGHLNLSRAEKCASKDPALSRKFRGDARNCFLGALSMCMVHCPSYSSLSKVYYLDGNLKMAEKMLRESLAIDPLNFQSWQDLGKLMAEFGRNDEALEAFQTAASLAVNTPLMPFQTIPRVFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDF7</accession>
    <name>A0A914HDF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription termination factor 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16337.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16337.t1"/>
        <property type="gene ID" value="Gr19_v10_g16337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF50">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="335"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="741"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16337.t1"/>
        </source>
    </evidence>
    <sequence length="945" mass="105973" checksum="1D6569EB3E5BC6C3" modified="2023-02-22" version="1">MDPSVNEFSFQQFSATSTPMPTSLYQKKRPLLNEQNLQTSLTFASPASKKPSSNLEGSSNETMPDLFFYDKTNSGLFSFEEDAKDGQENLQKNILSSVEEANSAESGSTVEGSSSQIYVKNAQRHRPKRIISSEIEESILSDSAKENEAPQNIESSSVNIEEIEEESGNDSQNETNLSVTTDKRADEHIETVDDSLSDGDDKAEESVLIEEDEESIENDGAILNKIDERQNHQLPRAPQPYNISRKPIMISAPNILTEQTRPAIYQTMHVQPGRLFGGKMTDARFEKITGISNDIINAMHSSLSTLPENVPTESPEGLRVDLMPHQKTGLTWLVWREQQMPPSGILADDMGLGKTLAMISFILHYKNARKENPDEMLRTDKQLRRRYIDGAFLIPANTTLIVAPASLIFQWDKEVRDRVKGDLKVHIFHGPKHKRDIAVERLIKYDMVITTYDTLVSELKNQRVNLIGADDSDEFPKAPSSVLAKIAWERVILDEAHEIRNKNSLKFHCCCSLEAVHRWCLTGTPIHNKLWDLYSLIHFLRVSPFSEEKVWKEFIMSSSATSAQRLNVIVKNVLLRRTKNQICAETNRPIVDLQPKNYELVTLDLQKPEQHCYTIMFEASKQKVRELLQEGALGGYGGLRRVKPGAKIKNPFVGGGARMAVDDHFKAYSSILTLLLRLRQACVHLSLTKNAIDIDAFKQDDDEADGSTENLVAKVLEISMAQMTLDEDELNGNGGITGNDQIEQLFKKEHKSTKINALLSRLIGVVESGDKCVVVSQWTSMLAIVEFHLRQLSISYTSITGEVRTDERQPRVDSFNRAGVGPKVMLLSLTAGGVGLNLIGANHLFLVDLHWNPALELQASDRIHRLGQKKNVFVHKFVCASTIEQRVLQLQEKKTTMATSVLEGAAKRVGKLSKDDVMYLFELEKRPSNPQKAGPSQKPPMSSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE32</accession>
    <name>A0A914HE32_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemimethylated DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE32"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16505.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16505.t1"/>
        <property type="gene ID" value="Gr19_v10_g16505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053189">
        <property type="entry name" value="Clp_protease_adapter_ClpF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48439">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48439:SF1">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemimethylated DNA-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16505.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13247" checksum="AEF2887C6366AD23" modified="2023-02-22" version="1">MPFKKLNRVGQVVKHRIHNYRGVIIAWDEKAKAPDWWIKKVHGAEPIDEPNYTILIDTRDRLIPQIAYVIERNIVLLSNNAIVHPLVKHYFESFDGTCYKSRPWHTKVYPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEQ2</accession>
    <name>A0A914HEQ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEQ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16457.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16457.t1"/>
        <property type="gene ID" value="Gr19_v10_g16457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037916206" evidence="1">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16457.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14418" checksum="7C223A563C5CAFC3" modified="2023-02-22" version="1">MAASFILLFWAVLIINCSSLAEDPLDLEKHLCAKAGLHPADGFKMITTDLIQIEPFKLANANTIHGLLLKPQEDKVGVTVVDSKHCMIETIFIETLKCNKEEAAKTSQIQHPECDDTASHCTPLRYTVPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFM9</accession>
    <name>A0A914HFM9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFM9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16188.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16188.t1"/>
        <property type="gene ID" value="Gr19_v10_g16188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF279">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN UNC-105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="936"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="989"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1063"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="936"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1063"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16188.t1"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127386" checksum="414E313487DF69BF" modified="2023-02-22" version="1">MMVWNTDGRRTALVGLEEEEDDDANGHMEEDESSSQVMIPKAANGSRSQQQPHQAALSSSSQTNPTHPQPGGTPPPTRRRPAERQISENSSGAGSVKRKISTNPYPKFSTSSTPNTAPKASTQYSVNVPSRPRPKRTTSENSAGAGSAAGDGRKESKQSVDSRGTTATVRNEANRPKRTPAELRRTVLLANAEHSHPKGGPHAMNAFRRLSRADFPFKRASDRMHMDSVKKIMEKFERHSTIHGICHASLAPNKRWRRFWLAVFAVCFLILVIQVVYLIIKFFGYPKTVDLDLKFENAPFPSVTVCNLNPYKASVIDRDESVQATMNAFQNILEETGRSEGVAAAIASSAAVRRKRRQLQKKARETKNFERRYLQVYAQCYCELSRLSAERRRGSCFAAYKGNVSLSFGVDSQLHNYHPTKCLCQLDWITRTLWPCFPYNTWKEHICIECVDQLGHCPMRFPAYTIAPAGPNGDQINSTTNNNNKAKRNNGRRRKNDPKNVEQPSQQQRVNMVQSLEDGMDLCVCHQDYNHCVQNNINGEIPEVLPNADLNTLNFMQIFVDSPLGQQRGENRMKTMTTQTPEIVQAMGFEELKDEIAIKSRARENLMFVVEEKPKEERIKMSQQKDELILKCSFNQYDCDIQKDFKLFYDPTFGNCYTFNWNRDAHVTAHRAGANYGLRVMLYANVSEYLPTSEAVGFRITVHDKWIVPFADAFGYNAPTGFMSSFGVRMKKFFRLEPPYGHCSEGGEKSETYIYKGYSYSIEGCHRSCTQNEVIRICGCADPLYPVPDNAYSCKVSDPVARDCIKNTSRMLGDLIATGALKNCKCHQPCRETAYEVTYSAARWPSGTTKLMECESSDNLCMEKYRTNAAMVQVFYEELNYETLSESVAYSLTSLFADLGGLTGLWIGISLVSILEVFQLIWFCLDFYRNKKKQQQQGATAIPKKQSTTSSASSLHRTSMRSRKSTKSSMKVASVQGDIVPPVSVVIQEETDEEQQSDKSSSSDSSQSPKRSKGSTGRYLAPGEDLPCTCLYGQRGQIVFMKPLCPFHGYMVRRVSIYSSNDEDALGEGKEEDEHESSSSSSSEEEQRKQQDAGVDENGGIMPGAKNRPLRQHKTELVTTTGTGGGGGEVSDYDQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFT4</accession>
    <name>A0A914HFT4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFT4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16569.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16569.t1"/>
        <property type="gene ID" value="Gr19_v10_g16569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16569.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12789" checksum="F8BD6AB0E23CA5F9" modified="2023-02-22" version="1">MDSAPDRVHPSSECLAHRLADPCLISPVNIQYFRCLGQNREGSGQYNENKKQNEFCRLHRSASEQYVYDPNFSRVKKEERKSERRTERNRWAAYSSEQHAFSQSQHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFY6</accession>
    <name>A0A914HFY6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">MIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the InsP3 receptor family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g17013.t4">
        <property type="protein sequence ID" value="Gr19_v10_g17013.t4"/>
        <property type="gene ID" value="Gr19_v10_g17013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005220">
        <property type="term" value="F:inositol 1,4,5-trisphosphate-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000003">
        <property type="entry name" value="Protein CBR-ITR-1, isoform a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000493">
        <property type="entry name" value="InsP3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF102">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00779">
        <property type="entry name" value="INSP3RECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2593"/>
            <end position="2613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2673"/>
            <end position="2699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2739"/>
            <end position="2760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2780"/>
            <end position="2805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2917"/>
            <end position="2944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3151"/>
            <end position="3176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3188"/>
            <end position="3208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3220"/>
            <end position="3240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3246"/>
            <end position="3269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3281"/>
            <end position="3306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3326"/>
            <end position="3344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3425"/>
            <end position="3447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3459"/>
            <end position="3481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3519"/>
            <end position="3539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3559"/>
            <end position="3581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3587"/>
            <end position="3606"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="273"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="997"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1223"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1306"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2821"/>
            <end position="2877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3632"/>
            <end position="3683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3050"/>
            <end position="3077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1227"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2852"/>
            <end position="2867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="3642"/>
            <end position="3652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="3666"/>
            <end position="3683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17013.t4"/>
        </source>
    </evidence>
    <sequence length="3693" mass="416846" checksum="025C44C9A547C5B6" modified="2023-02-22" version="1">MAADHRLVRLRSSFACSNPSITDAFTSSHLRIGDVISLYAVNSRSHRNHQGFFSTLGLVDDRCVVEEGKGTIQSPPNTFRDCLFRICSVNRYAAQKQYWAEQKKARLGEAVDEEMLEKLKVAAEKEREQNELEYSKMLGSVVQYGSSIQLLHVKSNKFVTMQKNSPARQERNAMRVYLDRMGNEGSWFCVDIVYKHLSIGDNVLSGERICLVPYISSTLMGVGSAHQGPKLQLQLHLSSQRLSDHKEAWEVNCLNEQTEWQVHVYLQFDENRPEHFKSGDVIRLFHADQQTFLTLDNEPRSQKDRVFLRLTNRPSATDATSSKALWEVQVHHSKEMALRGGAATWRRYIRFKHLATDQYLAVVPISEERKDPENRRPLSSFYSPSASAVHFQVPNSETYQHDSDTFVLVPKHSEDPIRDEDLLFTLDPCAKCSTKESRVLIDTFVRLQHSKTGCWVHTTNPQNSSNLYYSGKNEKGWVKVVCEGHKVDKEAFAMLPVPPNEVRDLDFANDACRALLQFVDLIRSGRSVGKEAINSTTQLLADAIYFVTNSTNHLADPLRIVNFTPIRDRQKLLREQGVLAQVFALLKAPFMPRQGSGEVQPLLASPQELTEPRNLCFRRMFQLCYSLLRCSQNGYRKNQEFLAEKFDQIQEQIGFNLLAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRCGRFLTYLADLCMCRGEANKKIQELICNSVLSERNRDIFMRTLMKPLANANDKRKFDVSICWNYAGANCRCLVACAESVREEDREMIDYYRHQLELLAQMCQDQQYLAIDPPPERKLLNFSRELPVDLVLQCMSDPRLPFDIRASFTRLMLHLHVIRGSPVPAVRHARLWRDIPFDVNVKNFISAAENYGEGARDRPEFEEFSHRILKMVDEYLAGIRRRARAGEAVLKDKAENAHENRLTFEIVNLAKALAHFGFYDFQELLKLSQNLLIIVDSCSGRDQRSTNQKTDRAKTHSKLIRQLTKKFSQQPDERSSTASDPPPPPLPSLSISTHHPLLKRTSTNKDDRAEVEAAERMANAKLSREMLLQTKLIVAELLQFIMDIRRDFRITTALSFFKRNFQCNENGELSVAAPDISEELIQQMCRIVFRWRNGDNELDLDKEHGQQLLRILLQMTMSDFAPLTSLSLQMLFRHFTQFQELVEDMGQVQLLVSNKEVQNYHQIDRDLFVLKSLTEKSELWVHHRFGGLGNGAATDCSSPSNPSQDRSRSISGDDLSFPNADLPPVDLHSQVAAELAAAGVLLDGSGASAVMPSPTEPTAPLESATARRRRTLLGMAGGSRRGKGSTASNSSRGGPGDLALFSIGDGPSEGVGNVQQFVQHQYTKLASKVAHSVALLANSVDKTELGAALQELMDKTPLASYLIVREILFRMKNLCFEGPKNDPMNQQLLRNMRVYEIVLEFLSIPYDKKNDKEMPRLIRLSHEFLRSFCRNNRENQARLAARIVTAEGGTTDAAGAVKEGGKMLGIDTAEDCATIVAIYRNNAELCENVSEQLIAHIVGLIEQKQRNAVFLELLQVIVSSCEKGLNECQIKVVEEIGKVSDDVRQLYVDSASFEQLIEMMRNCSLTDLDAAHPLRYHIELVKLMAMCTKGKNEATELKCASFLPMDHIVRVMTSRECIVEVKVAYLQFLLHCYIDTDIELKDASNGEYLDAILEDAIGDMGKLSTRLRQMDYQPKFGPEIIALERYVCETVTEVLVRVFEPASYGHPAHMDIRQQQKRFASIMQRLSELQNGVLRGRRHSNCSKNWYRIVECAKRLAKFASECGIFPTMNNLGVPQSVGAAGGSVGGGGLRALTPRQRWQSAAFSACFIKRNQQSVRANRPEGSSSSYCYPFGGAPTNVVCCFQLLVSELCQFLRPLQSAECSVLVDVLHFPEKLFCAFGGKSQQSQRKFLCEGEGVRAKLIQHCKLLLLEAKQEELCGRVLMTLCKMASTSRLHLYGDQGTSVRRDLLLRYFGAGSVQGNGNESEELSKSDCSGPAGSSADECLFDTELKPLKETSLYEIQCKLCNAKAVDLVVDLVVLDPSYDIFLKTIQLAKAMLHGGNEQVQMSFYQRLQERKLSARFFKTLLLKMQAAQNRIKADMICGSLARSRPVLSTVVSRRSSAAVTPLTAPSGFGHSALRRVSLASIKFREVGGKQRVEGDEMKSAPTTMSVPLIREGDQQEEGAEEVQQQQHGGTFMDEEDDLWECPPAEVAIVEPILRFLQLLCENHNSLLQNFLRTQKGKPDFNLVSETLTFLDTICGSTKGSLGVFAEIGVHNVSLINQTLITLTEFCQGPCHENQNAMAMHESDGLDIIISLVLNDIRPLADHRMELALEIKSNASKLLLAIMESRHDSVNADRVLRNMGHINGGGTQLLKAISQKLLLEQNVKQNDLKPKEDEKGREGDGTFWRRIAAKVPFIGTKYAIPQKRLQNSQIVSPTSQQTNFAIGTLADPREVGHNIYILAHQLARHSGELDSLLRPEKAQDENTREALTFYRTHTGQIEIVRADRKMERVIFPIHKICAFLTSETKEAVFVNTEKDAQGSKVTGFFERWPLLYEEMKWQRKLQDRLWLSACTRRLPLWGRMGFFLAVLVNLILAVAYPFDHKDTATRPLALSPGNPFLYLSVVAALLQLYCSTPASSSSGNSSADWQCLGLSRSSQLGIFALMVSSTLLLIALFGLLSALYFLGLFQLVNKCVHIASYAGNRGFAERNWRDLLMDSTILYHSGYLLCCLLGLVVHPFIYAFLLFDVVASEDTLRNVIRSVTRNWQSIILTGLLALILVYHFSIIGYLFFQRDFRLEVHKLNKAHLDDPNSPSPSRVPCEFNQQRDGDGGGEVAGQCDDRESDKRNRDKKYPEDEEDEEEELKIPSCDTLLMCILTTLNWGLRNGGGIGDVLRSVGPHEPYFIWRILYDMTFYIVLIIIVLNLIFGVIIDTFGDLRAEKNEREFVLRNNCFICGLERSRFDNKSVTFEEHSEREHNLWHYLHFIVWLQVKDETEFTGPESYVAKCVKERNLDWFPRMQAISLKEDSTGDSEHFDLRDLEEQIRQNQNALRELGQRMHEMNQSLLESLCICFGRLVDFDSAEVINYLLCEVKSSIKMNSKKVPRYQRMSKTWPKRVPLSNSPSPVANNHSATNWFSIYVAAALSFVGTVQFSLYFSSLWPYLQMIDRSIDETQFGWVIAMYSVGQIVSAPLFGYLSNKICQVRLPLIIGLCLMFFGNIVYLCLEIVQLPKLYVLLFCRCIVGMGSGNVCLLRTYASTASTAKDRSRAIAFVTCGQALGATSGPAFQLLFTYFPYPGFSLFGVLNFNLYTAPAYLACLMNLAGVVVLFLCFEEHYAGLEEANVKECRENGCAGDKHSGTDEAKLSKLLPYDVLACLVCYFSRFTQMFVQGNLETIGSPYAMMMFAWSEQKAVQVTSIAQSLVGAITFGIYILYISLKSKKELNCRLSCILSFIGLIVFHLITFSWPFLPTPVRTFNETRPEIEPRPVGCNATKFSWCQHLSQVNVWLYYCSYVVCIGLTFPVLNIAMNTLFSHILGPRRQGTQQGFFQISGTFARLLGPILMSSLYSFHGPNMAWAMELAVAGATLSLWLIFYRRMVPLQTPKQRSLSTATSFSRLEDGRFSTSGSVRSVEKERGKKDSSNAFEKPNLKNYNSTSTTTTTKTTTESITEGTHCPRLCPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG29</accession>
    <name>A0A914HG29_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG29"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1684.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1684.t1"/>
        <property type="gene ID" value="Gr19_v10_g1684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036919683" evidence="2">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1684.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="14814" checksum="B834825897028B4E" modified="2023-02-22" version="1">MLSIISIFILLLSGGTSSPTVATPNQEDESASRSDSVGSDNSDNTFSVSQVYAELYPPVKALNPANSSSVKLVEPQLKKSLSFNPKSPGGNSTFFNDQQPLQKSLSFKAPKTINSENDAKMRNILTDWCINIPNRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHA6</accession>
    <name>A0A914HHA6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHA6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16614.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16614.t1"/>
        <property type="gene ID" value="Gr19_v10_g16614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF1">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16614.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19774" checksum="839EEF2C9F76EE44" modified="2023-02-22" version="1">MGMPRYGGREQDLLGRPAGLHGTGRGRAADCFFSNTNNWAHLSGQFSKCPAGAKCQCHVPSTSSFCPRHTDFAAMPECLRQSPQQCRVIQIDAKVPIEWALPLYGFLMPLIVAITILTNSFIVVVLSHRSLRTPTSFVLGAMAITELLTGLLCLPGKAYRLFGAHCSLIWPPVFHRSFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHC2</accession>
    <name>A0A914HHC2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g17175.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17175.t1"/>
        <property type="gene ID" value="Gr19_v10_g17175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="2191"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="2191"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1565"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2050"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2162"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1582"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1606"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1634"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1660"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1732"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1757"/>
            <end position="1769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17175.t1"/>
        </source>
    </evidence>
    <sequence length="2232" mass="258177" checksum="661F0590D5E747F5" modified="2023-02-22" version="1">MEQSDVRHYIPAFAFFADSFNFPTNFVMRPHGIFAAYNQRDHGVEDARARDESYRYNLPQERGFARNGESPPDLRNGFNRSQTTLNSMHRSHQNRIRDASDRQIAARVMSIIHDEQGRTRHGQKVITPGDEMSDSDDDFIVMNTVKSVFDEDRQAQQLVIHEHHHYHDKKKKSKKNRSSSTSSSSSTESPESRKRKKERKKSRKEKKKERKRKNLNELEESSVDEGPSNRKRHAVVSEFDKKRNPWKLLRKNEWNYKPLNMVVDTHGDLENLNYDSSHRGDVPDYRSLNSEDNPFWRVFSEQFRGLLSEPTNSTVSREQRSFSERVMKQWGKRAPERTFRNRTNEKSFEHYVKLSHAPCAENEEGAISLNPMKYELGEQLLGNINIEDYEHMIRSQQASYEEALESDVQARYSILQTKVINEPDNVDAWLKFVDIQREMQAKNESGDPKAPVQNTKALFEKMEGVIKRALEYKNVSPSNPRAVELHLKYLKIMEDHFGPQSDAVLEKWKRCENRFVNSITMWRDNIRMRQNDRTVFDLKKMVLMGPPSESRLPLIDHCITKLVDIKNGTIKTHKMLEGTEQFLVDLLVQRCRLQVVTGHIAKAVAVMQALAEFHFFRPEIYKNFRPGTKPHLMQQKLKEGFKAFWCSGLARIGEPVANGWFRFETSDLDFQQPRDSEAEVLEQKWNSMHDEEKSLLATFKGLGLPAVEVRRRLEKFRTKWFWSPVHFRHDDERLYEHKTRIVSFEELEPLLFSFTDAKYAKDLIFKLLHILGVPIPDVFIETQENVLRQFSRVFFASNSPVSMELSGFDLFVEYFVTQLAESTLMDSPRIYTALITSVSNSTLPKHKKYTALMKLVRTKIQSLKRYGRELKLSMEVQLSLYLTAFEEMVKVKQEIGDNCEEDKSLTKESVECDLCLTVLCMNLDKKQRSLWEIGETEPEDLDKRKQRLFYLRFAVFLARQLPFSTDPSEVIGHLRTKREFLHSFFYHGRTEQVPLNAETKGTAYQYFSRRLIHPAALHLDDPLRWIGDENELVFELCSYYAYEFPIQGIPKQRFSAFVLDESSLYGSALAKLLRDRPCVQETRVLILQHIVATSSYYTPGELRRKLSDLALRFPHNIPILRALLSVGSNFYKRQFLTQHSGTDDRSRLIRTCGRIFAAFSHYTREVQRYQDQKYDNQAFRALLAQLVHILRRAAEENCDNSLPDDFIWIFLINCITVNREMVSSRIIDEIFTLGQGRCPWSKQFLMESLRGCCKPSDSSLFLFGPGGAAVAGSTLILESLLCRLSLELIPFLHTQFFLLRANCLLVRLGPSSTYLRERAANDGRVGVWAADGSRAFIWLMWRGKGTFVHMAQMLFHRFAVFWAKRSPMEPPRLLSLSVLLVLLSNSDAHIWPLNGRPLVRDYRGRVLLLVFVSLEQSPRGEEQCKRELNRLDALSEHFADVRVLAVAPREEDAGKVRAVAWQFPRIRFEQATAEAPIWSLFDAKHLDTTIFDRCSRLTAWVPSGSDFAVTLSAVQTTISSSPCGHCDFDSGKKRILWPSFHPPVPQQPTSSKVFVNIDGMFAGPASSLRRWNSPSPPVFQRGDTKTAKRLHWTVDKEKKKADVRNKQLQQISTVGRAPSNANSRPLQQQLHYSQKQNFRKQQQQQYLYGQQLGNLQQQQRMREREKEREEREKEEKRREREKDREREETDKEREREREREKEREREREGMRGRTEPRQHWTLLQQQQQHQQEQQRRGADELLRQRTEGFPVPGGVRQSKDDRIGMRDSVGHQPSMGPQHRRRHQAAPKHQQIMAATTAGPEPAPLYPEGSEDAAGYDYYGDEYAAEWTTEAPEAAMQIPKPTGPVMPTNPTTQADKNFGFDLPCTGFSDESCFQQQTQLRPNEMHRCCRGRILFTDQCVAGKCSNATVQLCCIQRFLQAKLSCCSDERQADVDVGDHFSRCCFENFVDGEDPCCPRAYAAEQWRSVHELCLPNVEMDLTGVKVPSPLVGTTLITEFDFSKTDRWRFECRYGLHVQQYSFFEASASEEEGDQKRGEEEEENDTIITPVVGRQTQRMDQRISTTTGNSSSRPKQQQNPAYFVVSPVGNAALPPSEVSLNSRAFKREITLPFPPLLSDCNRGSGCAAWWGRFQLIYPDSQQPVPLSHYVHGPPAPIVLPMQHSKYTSTQPKALPKTSHHQPSNKRPADPLVNEKYKTMLCKSYTISGYCAYGAQCLFAHGDRELRPCPGRQRRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI70</accession>
    <name>A0A914HI70_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI70"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16859.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16859.t1"/>
        <property type="gene ID" value="Gr19_v10_g16859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16859.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14155" checksum="88B8C4B1DFB9B7B7" modified="2023-02-22" version="1">MRPGRGLRVEEMTRPEKGRGAGSGGGNAGEAQQQCVRRFHPKCQRRMRFHFSRGPPLLSPLRFLTTSACALRAPSSRAPWQFLRWDARLARWPLLSPLGSEVDYAFACVPGGGGDGGGTHSTSAVGDLPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJB5</accession>
    <name>A0A914HJB5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1</fullName>
            <ecNumber evidence="21">3.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="36 37">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:75163"/>
            <dbReference type="ChEBI" id="CHEBI:78907"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:42305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42584"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82605"/>
            <dbReference type="ChEBI" id="CHEBI:82606"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:42585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65221"/>
            <dbReference type="ChEBI" id="CHEBI:78911"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:42309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:33752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78930"/>
            <dbReference type="ChEBI" id="CHEBI:78931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:42321"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="20">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LIMR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17702.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17702.t1"/>
        <property type="gene ID" value="Gr19_v10_g17702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19814">
        <property type="entry name" value="Bbox1_RNF207-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14524">
        <property type="entry name" value="PTPMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001054">
        <property type="entry name" value="ATPase, AAA family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000060">
        <property type="entry name" value="Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044596">
        <property type="entry name" value="PTPMT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="29" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 31" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 28" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="922"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="966"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="1013"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="32">
        <location>
            <begin position="1194"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="33">
        <location>
            <begin position="1268"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="34">
        <location>
            <begin position="1858"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="35">
        <location>
            <begin position="1915"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="2224"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="2498"/>
            <end position="2570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="2587"/>
            <end position="2655"/>
        </location>
    </feature>
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        <location>
            <begin position="2058"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="2536"/>
            <end position="2547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="30">
        <location>
            <begin position="2548"/>
            <end position="2560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="2610"/>
            <end position="2622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17702.t1"/>
        </source>
    </evidence>
    <sequence length="2692" mass="302363" checksum="5BE58A167C1DBB18" modified="2023-02-22" version="1">MDESDWIYFCIVVKMINFHIKGSSAHSGQFGDANRVSDKLDSNMYKKAIECASVTAEKSGPRAVGNECAEGTATVSSGTKCARRENAVHPANSGVFSHCARRPSEAGLELTALRASSFPSVPTMANSTVRCNARGPPANANRRLHNSTNNDAMSDNVSEEEQQQQMQEIFICADVWLGVFAFLSPLELGHLIALISDRFDVLVDEHFKTRKWSLGSLELRAIGGNGAQIGKNCCGEWLPIPQGPLPNKVIGFNEIWISYIDQTVLEFLQRIRRLFDASGTAVSIHTFGSASRSWEIIRQKIWPLVNDNICRLLDSQLDLLRQFSPTVLRNCANLRWIESMELFPEFPAEDNADASSRQAVAKWLLTRRGDGRPKMLSCGYWEGMEGLKGPFVNALEPANFIIRLSDSPSAVIEPFELKNNWTGERLTLRQKDEYRWLLVRCPFVREEAKWAAWEKEAFEWELFRQWNRIFLIFYDSDIGDGMVDAEAGPIVLVSTFFGWLFSFSIIIVLPIDVAITFYKKCLVEESHRSVVDDDTTTTVPSGGDYRMADNEYFERNESFMQCEQPKGFVEDKFLLTLWRIVYWSSQFLTWILLPMLQSYAKAGEFTVKGRLKYAFYSNVVYYGIYFATFMLLLIYAVSRGVSLDFENLKVLLIAASNTWGLFQLVVLLGYGLIEVPRLFWRLGIKGYRLKRTYFDIDKMSSEKNESDESIREVYTETKNALNLLKSASGPSREKVKQIAAKFPYEFVKHLNGSGADPKESSTALPISSCSQLDIGSVNNDAYLIKLHRKVINAAQNYRHCQAQWHSLIESAFYLEDVELAEQSGLLPAQWARLDVGNGGTNRRKTKSAAAALSLLVAALPGYAKARFHLFVTLRRPISQCLAVCFAAMTALILWSECTFFIVSPQLSLAARVLHSAARGYHYKFIQLCAVAMILYLCCCAYFTIFQLRIFRYYRLDSNQTTGENSLIFSAMLICRLTAPLCLNFLGMIHLDSHVTANRGFETQFTKLMGHLDIIPLIAKGIDIYLPIVIVILCLTTWFRLGARFLHNLGVDQFLEEDEMTHEMVQSGKSLVSLERSRVNRIFGRKERNEAWEATSKGMAGRGLANFGVASSNRRGEDVQPILEEVGDDSAASADGGWHSERMLAARLDTSSPNVELGRIGRLYGEGGAHSSEQQQINPHSRYVLRKCGPKRWSWYSRINDTLVLGAMPFLSMLPELKENEHVGGVVCCTEEFELEAAWGAVKPTDWAQSDIQFHHTPMRDFIGSTSLQNIEEAVQFIDKVTSKGQTCYVHCKAGRTRSATVAICYLMHKFDFSPEQALDAVSTKRPQVLLRDVHWQSISHFRKTLDERKEAREGEDTHSRIDPGTQTVGFMLRTVTVFLVDLFNVFTTFCRRRLLPTLSAIMCLNVKVREGLKKAIEADETRDDKSGVIVLYKNVLKLLQRALDIRLNSCPLNKHSEVLEQQNKLSDFVAQTQDRLVKLEGLERNRRICIEPKAVKAAPFSLASANGSSSSRGMPCTSTAAKTFATKHPIESKTSLLKNVEPKLGEEILGTIVETTDTRLDDIEGNAMAKLALEENVVLPALNPKLFTGLRAPCAGILLFGPPGNGKTMLAKAVANECHSTFFSISAATIMSKWVGDGERLVKALFQVARNAQPSIIFIDEVDSMLCQRFEQENGAARRVKTEFLVRLDGCSSGSSDDRVLVLAATNRPQELDEGILRRFPQRIFIDLPDKMARFQMIRRTFEQNSTKLQLSDGELEKIASKTDNYSYSDLKALCRAAALLPVQSARKENRDLRRCTVEKLRPVNFKDLESAVRSVRPSVNAESRRKFLSAMSSDAGDGLESALKRQETGGLQNPLDCLRCNSAIKAPVRLPCQHHFCRLCIADEKCCYVCGRPIGCSELVEDKVLNYVLESSREVTETCANCDQISQPMFFCDTCHQPLCSGCRDTTHKAKIFSTHHIVELEERGRLQSRPFCAQHNEPFILFCLDSKSLMCIECFNASSLERRGHFVNIDVAHKICCDKLEKNALNLRIFQDELREQIELRKRLTLELEKNGEHLSEEIDQKCEAITKRVNGLRRQLLDRVMEEKAEKQRQLSAQLNKLTTLGSPISVNLLSVSIFCSYASKMDVLHCYADLHKSIQQFLSSNGRQLIQRVKFDCNFNIDFAAEFVQSVCQPLGLSASTLEDNANAHDIFLNCDPTARSSSMRHSSLGCQTNFSKRERQILSDLPDVEDPTPSKTDSGKASSAEVLSDNVHQSHRLADSMDNGAIPKLSDGDLPFEFNPFSTSTTTENMDININNNPLMDQRFSEQFQMIAVPLNGFAHEISEISKTLLHLQRDLTLRRCVVSPEDLLSKIASCEDAWKRLETHNKQVEGTVNHSLKQFWRREIERIQRQQLAVREKAREIVQLRSLAKRALKVSQQLKPFATQMASLISVIDVRRSSGSVQPSPMEQICLQITKMEPDSESRVAAIEKEETLRREAKLEEDRAQLNGMEALRAKKALREVRPPTPKMRTSHNIVAEMDRDRAGTDGPTSREGSSTLSSVASPSSSKKKQQHSHRRVHRSSDSTTAAEPLLNHAVSLISSVHEMEQLSPPNASSQMQEHKGRNGRHAQMGDDVKLEEDNKSSAAEKVGESSGGGTLTDVKTESAVTAAGEGHPPANMAITAQVVRGRDPKLLQAREKLLEAIKEKVKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJR1</accession>
    <name>A0A914HJR1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HJR1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17520.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17520.t2"/>
        <property type="gene ID" value="Gr19_v10_g17520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052123">
        <property type="entry name" value="Non-rcpt_Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46257">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE CORKSCREW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46257:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE CORKSCREW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="69"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="192"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="383"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17520.t2"/>
        </source>
    </evidence>
    <sequence length="479" mass="55099" checksum="8CE8E325AA3474D7" modified="2023-02-22" version="1">MHPRFFYDVTGERARELLFLYGGKGCDQANRIPRITRSPFIKGAALLTLSSPVKIPFCETVVNIGRDRFFHISTSGQEAETLLRQKADGTYLLRESTSCEGEFAVSVKGKNAVIHVRIHRRNGRFGIVPKDSFRGLADLLDNYVRMPMVQNDGGVVKLVAAFSTTRFTAATIDDRIDCLLRSQRKPGIKDGFVDEFEGLHREEDAQMFISCKEGRRTENVRKNRYRNVVPFDHTRIKLKSLAENDYINANYIKVPLDVKRYPEFGEFQRDYISTQGCLEETVNDFWQMVWQEESRLIVMVTKEVERGRVKCFRYWPDFEEQKVYGIKRLSVKSLQEQTTGDYVHRLFLLCAAENEDSGPSRLVHHFQILGWEDNESCPVGSVLRFLDSVNDCVLKEQIGEQGPAVVHCSAGIGRTGTYIALDILTNCIRRNGPQCVCDVQKTVRMLREQRATMVQTEAQYRFIYYVISAFMKSYRNIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK50</accession>
    <name>A0A914HK50_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HK50"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2060.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2060.t1"/>
        <property type="gene ID" value="Gr19_v10_g2060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF130">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2060.t1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47219" checksum="6D2A73B8A394B669" modified="2023-02-22" version="1">MLLCLVAVSLFIFAVCRLYGILSTHMRLKRTSDGIYNIADTIPFIGQAHVFPKNSFTFSSFLVEHANEAIRKGHHLMRWWFANKFFIFMMDGETAKIILESTVELKKGPDYKFFHQWLGNGVLVSDGDHWLRQRRMLLPIFHFSMLEQYTPTFNKYGRLLAQNLAELQGKRELVDVSPLLVKCALYNVTESVMGVQMDLEQKMCRKYMEAIKNFVIYQHIYALCPLYILFPVTWYLFGHGFATRRCVRALKAFSAKVVEDRIRINTANGGIKKDGLMHAEGSLYKGKIMAFLDFLLALKGEDKLSIKQVREQVDAFMFGGHDTIANLDRRSGESITNAQGPGILLIFLLLPIPSGESWRWSGKDKKSPATPKAIKAAEPKPESSVPGPSSAPVVAERDVGEASGNDFDTVDDFGAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK86</accession>
    <name>A0A914HK86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1898.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1898.t1"/>
        <property type="gene ID" value="Gr19_v10_g1898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1898.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="40288" checksum="07BB34E5C2568014" modified="2023-02-22" version="1">MLDNPREAQKQLKEIFVCDDVLFEVFKFCGAFVLGLKVALISGRFDFLVAEHFKSKEWSLGRLLIRRAKDGNGGAEIVKRFGDDGKRRLPIPQEPLPDNLIGFESLTIRYIDRSVIEFLQRIRPLFDSNGTILSIRTGINQRKSWEIIWHRIWPLINANIGGCSLYSSKLDRLRQFSPSVLADCANLRVIHSGYVFPMFPADDDADALSAQAVAKWLHTPRGDGHPKVVKCEHWPVMEDFKMAFANSTGPLNFIIFIWNCSSDGIVPFELRNNLTGERLVLQRFDEDFWLFVRCPIERDEYKWAKWEKEAAEWDCYWQWNHLIIDFKARDIGDDLANEGPRPKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKD4</accession>
    <name>A0A914HKD4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKD4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2282.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2282.t1"/>
        <property type="gene ID" value="Gr19_v10_g2282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2282.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17195" checksum="A549EE4688A9E4AB" modified="2023-02-22" version="1">MHKFWNCSTKSIGFSRIWNCPTERMKQHKCHRQKCFLLFIFCISAARGNGDSQGSASIGHAIGAGPAGRSFGNGTGLGSASRAGRAGPSSAAAGRENGTLAIVLMLFIALGITLFCFCIRGGHFFESEEEQSTRDACAGCNRCCDLCAILPLLLETPGACRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKV7</accession>
    <name>A0A914HKV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2420.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2420.t1"/>
        <property type="gene ID" value="Gr19_v10_g2420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2420.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35126" checksum="182874B25CA8A05E" modified="2023-02-22" version="1">MNVIADILWLIVKHHHQIPKKRCLNCRCHPSMALLLLARLFTTESWTSHVFGGNMAESVQLEELEELPLQTFDELFVDEWWDKDEAEDLKTPAPTNFAQNVHHQIDRQNTQKSDHSGPIEPNSTDQNPPLTESDHSGQIEPNSTDQNPPLTESDHSDNAKNEEELIAEDEQKEKFEQMKAELKRTGFKSSFKNEIDKTVAKELGLSFQTIYRWKRKLGQTAPKYPHSEQKELMKRYYEIKDKNSKTNDKEIAKMLKIGRVTLCNWKKQFKRQQFHPNSVDGHSDEENDGSNVQEIDKSYAGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL78</accession>
    <name>A0A914HL78_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HL78"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17650.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17650.t1"/>
        <property type="gene ID" value="Gr19_v10_g17650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="167"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17650.t1"/>
        </source>
    </evidence>
    <sequence length="583" mass="64152" checksum="398EE79E9787BC40" modified="2023-02-22" version="1">MTSKTTSKRASGATVGSKSNKQPEPPLSTSSAVNFFKIEDAASKELSIDKTIKESAAQIAAIRSLLTSSSGNVRRQELKDPLILRAVKLRRLNRYFNFRNNFARDRLAENLTNETTHLRKNIDVCMEFQAGDSDIGLVSLEEFNASAVAEVNGTGEVSEVDPHQLHLARLKHELGERRSMLANLQELEGRKSALLSDIRGKEQRLSQVRSKIQAIKKATSPLFDVLGLKARPFEIGHKAKALKASLDALSVQLRPLNTNEEFCREIFGTHSIELGCDGLVRIREEVVVEAMDDDGGTAEGNALAADGRGKEKAEALATARAKDFFAAEDALAEGISAEQIQTKALECIGTIRTLLEGHGQTMQQQQSSELLPNAIALRRLNRRSNLRITAARAKVAQMRARMEERTVELRNALVGVDFLKKCVGLCLDFQSHAHSDIDLIPTEQFFAEVPTFIPRPVEATRNDAHHLQMARLKHELWTRKNLVDEVKEMEQKRKASLEAIAEAEGALGRLQPRVETLKRTAKPLLDIVGLKSVVLSVHNRAIPFRPVPGGAVPAVGQGSSANDGVEDGEEEEPMELGDDDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM03</accession>
    <name>A0A914HM03_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM03"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2583.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2583.t1"/>
        <property type="gene ID" value="Gr19_v10_g2583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2583.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10356" checksum="829DBA0A2D412397" modified="2023-02-22" version="1">MSHQSGHNETHEPKPAQTSFFLWMNENRDNFYRPGMSQVDVAEAAGSEWRRMPESEKAKWAQKSADDKERYARELIEQKDRQRENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMT6</accession>
    <name>A0A914HMT6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMT6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2945.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2945.t1"/>
        <property type="gene ID" value="Gr19_v10_g2945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2945.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27032" checksum="F6335DB6EC24B8F2" modified="2023-02-22" version="1">MPFDGKVGRYDGTYGYDSLGHFLGHAHSINRKPVFKNGDVVGCGVNLATRQMIYTKNGERLGSAWRFLQSSRQRKSHRYESNIWRCPGAFKPNCNVFDYNCVGCEYRFGKKEGCRPHVKCSCYYCCDPKYAESCLDGCHNCIWDGKGGCNATFKSIGNSSSSMLESEESARKDFDMVDVDKNGSISLNEAIAYLRSKANGTLPKHLTKNMSWFADIDLNGNNQIEPGEFDRSLIGVDDQTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP88</accession>
    <name>A0A914HP88_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HP88"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2430.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2430.t1"/>
        <property type="gene ID" value="Gr19_v10_g2430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="341"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="687"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2430.t1"/>
        </source>
    </evidence>
    <sequence length="1136" mass="130490" checksum="84BE51FDA7154A5B" modified="2023-02-22" version="1">MVAKTRNWPRWKFFEYMNNRHGQQGRLQQETRQLIEQVGVPLNLEAYDADTYVPRVVDHWNNTQQQHRFAVFIFGSTGQYQPLFKYTDNTYDTPLLLYFNNEHFDGVQKQGGLFGQPYCLECERPYNKASNHNKSCKARCMLCGRAGPAFPCSPLDGFFKKCDGCIKKFRNNNCYNHHLQSGFCKRSKLCKDCGTIWDVPNNTKNGRVGHKCGEKFCALCNNYHNTERGCYIQQLEPKENDPYRLVAFDLETMQHLSVSPQYPDRRNHEPNFISAKVACPDCIDNGNWRSGTTGCQVCGQHRTIAFCQRHFTDTPIDKQVVADNPLEAFVNWLVNQLPPKYDTYAYSHFGGRFDMVLVFRELFKIGFNPDMLRRGNKMYEMRVRKQRGRNPNIIFRDSFNLMPSSLAALVPQFGLDVEDKPFFPHLSNCPINYGQQIFPTPDDYLANGMMPEKRRQFDQWYELHRHEPFHLDEALASYCTSDVDILMAALIAFRREFFEVSKRNDYIDGIDERQNHNGIDVLRETMTIAGACMRHFRTNHLPAQHLAIVPERGYDNAQNQSLLALRFFRWYAEENDVQVQTAHSPGGEKRVANYSLDGWIETEQRGIEVNGCVWHACKQCYPMDNQMLPSGKTAGQVREKDEKRLEFLRSQIPRVDVFWECEIHRMLERSKEMRKIFDGYVDDGPLEIRAAFTGGRTGPMKLFHKAGAGEKISYYDFTSLYPFVNFTTCYPVGHPTVHVLNEDVAWTTSADNPYPLALLKVWVVPPRKIDVPVLPVKVGERLCFPLCIKCAKEYPTGGVDDNYHCEHGDNQRGWVSTCTSLELNVALDEGYRVTKVFRVLEYNESDDTLFKSYIAEFMAKKIEASGFSANIKGNAELEEAFVRECHDMFGITIDAAQMVPNKGKRSLAKLCLNNLWGRFSLRNFGLSQTLITDDPVVLGEYLDNKSVDVTSIDELDADHILISYETKKEWVEEHACSNIIISLWTTSAARLLLLKAMQKVVRAPGCTLLYTDTDSLIFAHPIGSCPLQTGPHLGQFTDEYERHEILEYCSGGAKQYGLKLKRNGAEEADFEHVLKVRGMTLNFDVMQNQGLCYETFKNAVLRYATTEKEDVSFLPPCKNVIDHMLVKELLGPTLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQF5</accession>
    <name>A0A914HQF5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3493.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3493.t1"/>
        <property type="gene ID" value="Gr19_v10_g3493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3493.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8259" checksum="59D75980AF6E8744" modified="2023-02-22" version="1">MSAARFFARRRYVRGALFCAARLCALRAFLRGAAMSAARFFARRGYERGAAMCAAHLFALRGYVRCALFCAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRE5</accession>
    <name>A0A914HRE5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRE5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3232.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3232.t1"/>
        <property type="gene ID" value="Gr19_v10_g3232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037938861" evidence="2">
        <location>
            <begin position="24"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3232.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24299" checksum="09F4429E9F93AF5F" modified="2023-02-22" version="1">MEEFWILILVSLFATNSLDKAESVQLEETPLKIIDEIFGEGWWDNDKDEEWNKLTLEHTLHHQIDRQNTQIGKIEPNLTDQNPPPLTESDHSGQIEPNSTDQNPPHLTETDHFGQIEPNSTDQNPPLTTSDHSDNYNGEEQNEINVEDERKPPTPTTLRIPNPTSDQQPPTNAGESQLATQNVIFGPAEPCFLAKHISTLAILSEFKDSYANQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS35</accession>
    <name>A0A914HS35_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS35"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4143.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4143.t1"/>
        <property type="gene ID" value="Gr19_v10_g4143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4143.t1"/>
        </source>
    </evidence>
    <sequence length="693" mass="80920" checksum="D99EB72BB9768D58" modified="2023-02-22" version="1">MEYQVGHCDPTEKDECVPIIRQEQIMQTSGAEDIQMDKVFFFHTFPRHSAKKTFTIAIFGDLGLKRPEEQGVLEDKEGSTWKHADEILTAPDTLAPHAMESLMSLVHPGYHENHPILKSHLNERSSGLRMTNVQLILHIGDIAYDMHEYRMKKKMRVEDEDEDYNLGDRFMQVIEDIAAYVPYMVVAGNHENEEKTAEYHQGKRAKGSSEKFEPQFEHYESRFKMPRTFEGHNTSQYYDFTYGPIWFVCVSTEYYYSYVVKSPKFRWVPDWDNVTRQYEFIENSLKKANQNRHKYPWVIVLQHRPFYCTSISKVTCRFNKSHKHGLPSKNDPNKLVYGLEELFNKYYVDLVITGHEHTFELFPPIELGDGKPKVIPEKFWWEVHRNARHIDDENEELVDTRHVFKTFTDPVAPIYLIVGRPGNAEEMEKLYPVPWLQRITYSNRFSYTLLQFPFDVTQTKSTLAIRQVDISNGDVPAEFFVEKTFANYEPEVLCAELDLIDGGGESKYRMKLSDLTLERVQLRLNPFTKRRHKKRQSRNNPTEVDKKKQRRKRNTGDVEGSDRLNTRGLIRELLFAINRSENSGQKAVANKESILSLKKQLCHNINNSKHSDQKVRGRAKTAYSVENELTSKYNSNSSSSSLSTSSSRESEEQSRATRRRKSERNTKMPETERWLRPKRAPDTGHGNGTQTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSP3</accession>
    <name>A0A914HSP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g412.t2">
        <property type="protein sequence ID" value="Gr19_v10_g412.t2"/>
        <property type="gene ID" value="Gr19_v10_g412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g412.t2"/>
        </source>
    </evidence>
    <sequence length="183" mass="20976" checksum="9700A9611EE5BF13" modified="2023-02-22" version="1">MRANRVKIMPSQKRLSLCDISYSLTKEILVDARSVSEFSGKKQVDRNDVDFAIKTFNEKHCKDRPSRAFISELAAEKNAHPLPPIRQNFGLRLPNDRFCQLQPNYVYIEKDSVNADKLARASVLMEDSQPISSTKFAAMNNFDPDSVSNLLMTDKSVAKQRKRPYPNEEKEKSVPDEDDDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTP7</accession>
    <name>A0A914HTP7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g437.t1">
        <property type="protein sequence ID" value="Gr19_v10_g437.t1"/>
        <property type="gene ID" value="Gr19_v10_g437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036688304" evidence="6">
        <location>
            <begin position="33"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g437.t1"/>
        </source>
    </evidence>
    <sequence length="610" mass="68914" checksum="E3F75E7EC5070B29" modified="2023-02-22" version="1">MFPTIKVGILLRFRHNLSPWVLLLLSMPIVGAQLSHHYQLIDLDVPLNRSNPNKEKFTLKYKMFRGFFDPNSADSPILLCVCGQQNLRECYAKMQILEEFAPRLDAAIVYMEHRFYGEDKMPTIKFDSIESLAHLNVIEALEDIRSVVDDVAQKLAIWGQTPINRTVVVGEDYAGALALWLNLQKDKMPPKITWAASPSPLLLISLGHENKSLAAIPSFDQHLTDLMANFGCDERSLRAIFQWMDETARGEGQNGQNEGLDTVTGVLHYFNGIREKDKDPIGTVKEMALLWLRKFASERNAANFVEEKAKLVWPLEELCESISKASDGKAKATAFGQFIVLNEPTAKMGQIDYRMALDGSADKDRWTAKMFQQCTQMPLQICASGVPKDAFYKQCPGGEKQRLTERCEHELAAIGFNETESQLIKWDFVADTFGFDLNSVRNLIITFDQFDPLATINSLDPTNSNKTADQIPFRSDSSRHFYVFPSIGLSTRARELDVPNSCDPMALKQARTQIIDIFQCLVHPDKCLFKSDQWPFPLAEQDRQSFASNHSHECQKRLWHYYPWASYNGNSEPAPNSSAGSDASGRGRAVGWTFWMGIVAMLATAIQIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTR2</accession>
    <name>A0A914HTR2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTR2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4133.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4133.t1"/>
        <property type="gene ID" value="Gr19_v10_g4133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036804509" evidence="1">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4133.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10666" checksum="1649537690C1A95C" modified="2023-02-22" version="1">MFSLPPFATFLLLVAPFSHATEGGDDTVCCHDCYVAFRDCFRECLSNEPENMICVPNCKNELGNCSTEKCGRLCPFPKNPEFYPPRKYHSYGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV60</accession>
    <name>A0A914HV60_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PSD13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HV60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4271.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4271.t1"/>
        <property type="gene ID" value="Gr19_v10_g4271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PSD13 N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4271.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36278" checksum="2435172DFF951F90" modified="2023-02-22" version="1">MTEQRVENYLKDQTGSDNPLVAKGFQNLMNLYTNELWNELWQESSRLVRDIDFVLAVDLPQFYEEFIRDFERRIEPLQLVELVTLIAENIFYTDRQKAFDFLDNFDNLRRKDTPTPVASTCTDLPLVRPHNSSTWADACSKGLLDIVQHFVENGQGVDDTDEKGLSGLMYSSEAGKVDVVRFLLSKGAHVDRTTHEGVSPLLFAAKGGHLEVCKLLIANGAGTNQKSKDGETPWFEVCMRGHLDIVKHFVNERQDIEVSDIHGHTGLMYAIRAEQLRVVRFLVEEAAAIYDAPDVQGHTALTVAVAKANTFTEQPLNPAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVX4</accession>
    <name>A0A914HVX4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVX4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4268.t3">
        <property type="protein sequence ID" value="Gr19_v10_g4268.t3"/>
        <property type="gene ID" value="Gr19_v10_g4268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="5">
        <location>
            <begin position="223"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="640"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="735"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="768"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="801"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="854"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="887"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4268.t3"/>
        </source>
    </evidence>
    <sequence length="992" mass="109252" checksum="3C9C16E8DADCA81D" modified="2023-02-22" version="1">MSIPTATNGGDITRARLYSREARLKVCKLLIAKGANANQKSNKGATPWLVACGKGHLDIVKHFVNERQDIEVSDIHGCTGLMYASRTGKLDVVRFLLSIGASVDQTIKHDFTALLWAASRGHLDVCRELMANGANTNLKTRDGGTPGLIACAFGHLDIVKLFVEETGWDIEVSDNESRTGLMYASGKGKLDVVRYLLSKGASIDRIDTSGKTALDKAIAEGHVEVGKRLFLLKNPWTNLRWKGRFSEKDVTSWTPEMCAKLDYNPKDAQQFDDGIFWIDYPSICAFFDVFYVNWSPALFPFRHALHSSWDAGKGPVKDLYTVGENPQYFLELNNRHGTASVWILLRPFDPKPLLEGTRINSPHYLCQLIIREPVYLMTQFIKMLTLATFFPIVEGEYSFSYELMKSAVVMEELNKFALSAVECDRLGQTDEAIFIIRFLLKINMSIPTESTNGGDITADQEGLGPTLTNSDVSEELRLLRARIAQLERQQTMNSPTSSDGFYLVSKDEIEPNNNDKESMAYPEKEQATFELENKMEEYHNKQQQTIDTALPEKQNVGHGIDVSGHGIDVSESARDSAELLYASIIGKENDVRFLLSKGARVDRTTDEGFSPLFLAAGEGHLEVCKLLIANGADTNQKTNNGGTPWFEACERGHLDIVKFFVENGQNIEFAGRIGHTTPLMAYIKANEKKLPYGSTIKKIKQKQNGMGQGCCKGTRGTCGTSDTAVGQRIGVSDRRGCTALMCASRAGEMNIVIFLLSKGARVDRITNEGFSPLFLAAREGHLEVCKLLIANGADTNQKTDDGETPWLEACGNSHLDIVKLFVENGQDIEATGSIGCTAILEERKELASLFKQQYGCTGLICASRAGKLDVVRFLLSKGARVDRTGHNGFSSLLWAAHRGDLEVCKALVAKGADANQKSHRGESPWLAACEQGHLNIVELFVDNGQVNNVVRFLLAKGARTAQTDANGKTALDIAEANHDEDGNNVDPLTVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWF4</accession>
    <name>A0A914HWF4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5292.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5292.t1"/>
        <property type="gene ID" value="Gr19_v10_g5292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5292.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11376" checksum="8A2E8D4980F0C651" modified="2023-02-22" version="1">MTETNSAQIAAEQASSSASLNNAVRELQVIRARILELEDQQQTTNSTTRNMGGSWEQDPHYFKGRVQLLDIFTAAGATAQRPIEMRKLPHEEQEYQTRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY65</accession>
    <name>A0A914HY65_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY65"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5563.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5563.t1"/>
        <property type="gene ID" value="Gr19_v10_g5563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037506598" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5563.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16909" checksum="C747639C3865EBA9" modified="2023-02-22" version="1">MSKWEMVVELLLVLLVEEGEQDVPVPMLEREQDVPVPMLEREQEVPVLMLEREQEVPVLMLEREQDVPVPMLEREQDVPVPMLEREQEVPVLMLEREQDVPVPMLEREQESTSLPAPAISATTIRALLESRVEVELFGVRFIRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY95</accession>
    <name>A0A914HY95_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium uniporter protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY95"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5590.t3">
        <property type="protein sequence ID" value="Gr19_v10_g5590.t3"/>
        <property type="gene ID" value="Gr19_v10_g5590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5590.t3"/>
        </source>
    </evidence>
    <sequence length="289" mass="32728" checksum="C86E77A7CADF2E43" modified="2023-02-22" version="1">MAIINYFTITSVNQCHWGLSIVFTFQRDNAKVNANANANANANANANAMPMPHHKINSFPHHYILFILSGNNIQPSLGTTPSQQAIIGQSLELLQKCKVTLANGGDCSKHLNEQMEAMLLGGCKLAKSEPKLDDADRNCKALQKGGKQLLDDKSLVEKFQTNGQKMDCMGLWPKYYLIQRIRNRKYDGDYHPEVRQDAARNRRKRRNNELAVNGAVFALVWVVAYLIVSFLHGASSMVGELLDYGFISLALSYFVFAAFIRQQRFYRRGAASFENYLNNRGFQTRFDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYE0</accession>
    <name>A0A914HYE0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYE0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5629.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5629.t1"/>
        <property type="gene ID" value="Gr19_v10_g5629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF18">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5629.t1"/>
        </source>
    </evidence>
    <sequence length="848" mass="93281" checksum="0BBE986F96CAC920" modified="2023-02-22" version="1">MKQLLSKPKPFDNFCLLDSLILINCSPKKSISTCRTACKLSHKFVYIKAMDIDDDIFLGVVAEAAEAEERRQHKRERKERKRARKEAKRARKEAAAMAQLPQHNGADDDGGEAIAVEAAEEDAVMAQDIDEVNDATAAVEAQQIAEDPKERRRQKRERKERKRARKEAKRVRKEAEALTGQGNAEAEKLLRKRLKKKSKKRKKAKEIDEEAAETAPVDTAEDAGASRTQMSTSTSAIQRRTSSTTASATTRVAAASSSDDRTFSARRPVARFRRPYRPLPPRRTSPQLRALPPARRKRPPPSSPTAGEWGTRRRVLPRRASLTPSPPPAVTRARGTLRPLCARSLSPLTPPRAAQQQQQQRERTSSVSASSSAAASSPSSASSRSRSFGLFGQIDLINYDNLFILGPLCLRRRHVRVAVRPVTAASASSSSSSSRSRSDRTYSSDSSNEPKNRRSVRSYGPDASSWRMYEKARAEFLQKKLAAGGQLPAHVRDPKLISTLRRPYIPGGARRTTYGLVRGASGGMTTTTMTISTLRGRGFGRGRGRGRANLRFFTPRPKSEYLDDRGQIDKRKLLEIATENATKLAMEGKLPKGAELVDTIKIKSVEQLATLFRTFRSVLAVFLNTSSTEEAVAVRRMHLAGGHATADDDDYLLLQKVSSGSEEEGDEEERFQRRHESWKRRTQKAKEAGEEEAEADCAAAPFKKPFRLLSSEIKIKIAGSTQKSMSWLQLGKAPLPPPPVAPPTALSATAADGEQQQSSSSLAAFHPSLSAPMLAAALVRPIPKPPVPPVFHSSSSLCDLLPPPPMPPKLTPPPKPPLLIRRSLPEPPKPPVLIRKQSPPKDPTAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ18</accession>
    <name>A0A914HZ18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g540.t1">
        <property type="protein sequence ID" value="Gr19_v10_g540.t1"/>
        <property type="gene ID" value="Gr19_v10_g540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="69"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g540.t1"/>
        </source>
    </evidence>
    <sequence length="422" mass="47700" checksum="2398C366E75BFBF3" modified="2023-02-22" version="1">MAVDVGHSPLPAETTPSPIAPIATNNSVATNVAFPVEAAQQLQMTEQQSLVSILYLSYMPMCCVVGLTGNCMVVVLIRSNRIFKKLPSSIYLLVLSLMSSMFLLSLLSFWVEEGFITDQNEQHSMFLCKSATFLAHFCDFASVWLIVLVGFERLTLLYRVSCRRSVVNAKRHVVFLLVLSGLANLWILFVAQINEFGECDINADYEDVYHSFSLLETIFCMILPSLIIIFSNVFVILKLRDHLKKIPCSPTVSFNTADTVYSTGGPQQQHTIKSVKISKASLFRMGSSKDNEGLSVTATTNAINRLGVTDIATRLKLKRRHLRYTDLQLTRSLLVITTVFIALNLPNYVYRISIQFFVISEQTNLSFAAHVLLYTHHAILFYVYIFNSPQMRKRLVPTALKLLECYCLKPQHLNDFSDNLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZA8</accession>
    <name>A0A914HZA8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZA8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5464.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5464.t1"/>
        <property type="gene ID" value="Gr19_v10_g5464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5464.t1"/>
        </source>
    </evidence>
    <sequence length="387" mass="41682" checksum="1145F649243B29C5" modified="2023-02-22" version="1">MEKRSTGAAVMNITNLSFQSLDDDTECSWHTATGNHRRSSEDGATVYHSVGDDGNDNVMEEEDAVNSVLIVSDSDLDDEEVNTSSDGTPKATSNGSGTLSDCDDAEASSDGTLNVAAIGGEGVLRGILPSFSSEERTSNSASTTTPSDNKGSVQNEDGHRQKRMVQLLVEARKMKSQKDNEKLPKVSPGFQPVSHRGRHLQQAAKIVAHRPTNSAPLFGCIKHSLPNFRNLALNDQLHSFSPAVRVGGAEWKVYVKFGASKKIGLFLVLSKSLPCMGRKLAANNSTGYSVKITARILHPISHCAPYTKSIMRRSSKTLCFQCPTIAGNVHSNESPSSHCWGLADMAAIDTLTSCRGGFVDYAGKLTVQMDFTVLRAGFPHSQHAQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZD2</accession>
    <name>A0A914HZD2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="10">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline</text>
            <dbReference type="Rhea" id="RHEA:76407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:195196"/>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HZD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5483.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5483.t1"/>
        <property type="gene ID" value="Gr19_v10_g5483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5483.t1"/>
        </source>
    </evidence>
    <sequence length="474" mass="52894" checksum="72B6229529FF2464" modified="2023-02-22" version="1">MSFCRGPNTFSVPAQLFRENRIRLVTALRQKLGGAAAGACVLLEGGKECQRYNTDANDSPFRQESYFFWAFGVHEEDCYAAIDVASGKSAIFPPKLSPDYEIWLGKILPEKWFQDKYQVDHVHFQTGGAEIGEVLRGLFNAKKLLLLKADNTDSGNVLEPANLPGLDSFCTDVATLYPVMAELRVIKTDFELAVLRYASTIANEAHKEVMRRVRPEMFEYQLESLFRHISYSTGGCRHLGYTCIAATGQNAAILHYGHCNAPNDKLIKDGDICLFDMGPEYNCYTSDVTCSFPANGKFKENQKVIYNAVLRANRTVLSAAKPVMLEDLKSAGILRGDVAEMVDKRLGAVFMPHGLGHFMGLDVHDVGGYLGDALPRSDKPGLKSLRTTRTLKERMCITIEPGCYFIDTVLDKALANPELSQYFNVDRLREFRGVGGVRIEDDVIIWEKGNENMNADVPRTVEEIEHFMANAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I095</accession>
    <name>A0A914I095_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
            <ecNumber evidence="6">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914I095"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5413.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5413.t2"/>
        <property type="gene ID" value="Gr19_v10_g5413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="20">
        <location>
            <begin position="44"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="21">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="22">
        <location>
            <begin position="361"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="23">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="18">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5413.t2"/>
        </source>
    </evidence>
    <sequence length="960" mass="108123" checksum="7231BACE917038C3" modified="2023-02-22" version="1">MQPRPRVTREDGSVIEEQKDEKGDFNIVFRSDENENNENSGKFNPSKRMLKGRGYVVDFAPDLQVSNVSEGIYLSSQDVAQDLSLLQRHGITHILKLLDVPSDDLKKHFPRVQQFMRKAIEKKGKVLVHCNAGISRSSALVLAYIMRFEGHSLGDALVRVREQRPTTSENWESRAEIHHKTHCMANVSTNSSFNEDSKRIRSFHQKHSPMLTKHGAKLNAMVNDLVLQPMKQTTDMETDANAGPGEGGGAVSSSTFEPELSAFDDMAQEHKHPIHHLISRCGKAIDTRFFSDLSRLLKNEKQIEQNPDNLRHANRLILEHLMGLGRTQVADVFLQEAEMSSLDVPDIDNFGALKSIMSSFKQHDYLPAIQWVKEQWGDGTDRHDLLFRLQCQHVIRLLETSGKRQALCYVKEMQNEEKEKYKEELKHMMFVVMTHPQKGPHDYLFNEGRRFALERELANAITNYRSSLAKILNAGAKTVPSLMTLRAFLNTSRGGMATLPDELPCNVPVPEQVHSSFCCPILKVQSTEDNPPVRLSCGHVISTEAMQKLAQQSRNNRLKCPYCPLESVLQECKMIFHAICLRGSLPLSLYASRSVSIRPFCALADGDVLLERINRKLIITLNRPKALNALSLPMIRKIYPELRNSTFDLVLVKGKGKKAFCAGGDVVAVSKSYKANNPLDRTFEQFFLEEYRLNHLIGCLSRPYVAFIDGFTMGGGCGLSMHGPFRVATERTVLAMPETALGLFPDVGGTHFLSRLSGQLGMFLALTGYRLHGADVYHAGLATHYVESANLQRVQDELFVLSSPKCSDIDQLLRSHGPSDVASFVLDPHLAMIDECFAADSVEGIVERLSQRADDEFAQEQLTVLAKMSPTSLKVTFRQIRMGAKLKFEEVFPMEYRLTQRFIAAHDFHEGCRAILIDKDRNPKWRPSELSDVDEAVVDAYFAPFDIAEKELKLEKISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0G4</accession>
    <name>A0A914I0G4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0G4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5750.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5750.t2"/>
        <property type="gene ID" value="Gr19_v10_g5750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5750.t2"/>
        </source>
    </evidence>
    <sequence length="259" mass="29841" checksum="89A68F812AD9C976" modified="2023-02-22" version="1">MINENQILLGNLSIELNPFAPLPNGRIREIHLGSEQIKIAKPNSNNKFPVGHFNSNVNFEQLHNIAQFAMGNEQIVQIHPNKNVNSAPHLFHLQCINSWFIEQDKMECPVCRFKHNPKTLKFLPLLSENKQNEEHQNVLFLNYHQILEQILAEEKSGTFKHRQAKGALIGFEKHIENLNMKIKQIFESNEHKLQMQNGKIVPNDSIKTMKIMLKQILAIERGESSRNLLQELENVNSVLANIAKEAFDAIEMISEKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1Q8</accession>
    <name>A0A914I1Q8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione synthetase</fullName>
            <shortName evidence="1">GSH-S</shortName>
            <ecNumber evidence="1">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1 3">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914I1Q8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6079.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6079.t1"/>
        <property type="gene ID" value="Gr19_v10_g6079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037734095" description="Glutathione synthetase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6079.t1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52090" checksum="387319FF7447B28F" modified="2023-02-22" version="1">MIYLFQIYLATLFFLNYFDAESVNESGGIEVLISSQFDELNSSTNYTDNLLTILQRNRTKTELLIKKATEWAQNIGLLVRKRRFDANLQEFYETDVAPFTLFPSPFPRKFFEQAVNVQTEIHSEGIKQPLTVLFQRADYMLCEINYEGNEKPSYELKQIEVNGSAIGGLGFSTRTSKLHRQILSKMDLDLSNSVENNTSTMTVEAIYQACLKLDPHDFTLRYDDKIVAVVFNQETMLSADPEEMAARRSIERSTAIKAPSLAAALAHTKKVQQVLAKPGMVERFFPNPEEAPLIDAIRNTYANFWTIDEDDDNNDYTQIIQAVKKNPHKFVLKKTEYALYRNRNQNRIYFGEEIVKSIANFTPTERAAFILMEKLQPTIVKNQIVKPMFDKKMNVPPSIFEDVTPELGIFGTLLGNIVDGQVLDNAQLGYQIKTKLANENEGGLASGHSAYDSAYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3B7</accession>
    <name>A0A914I3B7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTBP1-like RNA recognition motif 2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3B7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6489.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6489.t1"/>
        <property type="gene ID" value="Gr19_v10_g6489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PTBP1-like RNA recognition motif 2" evidence="4">
        <location>
            <begin position="193"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="538"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6489.t1"/>
        </source>
    </evidence>
    <sequence length="643" mass="68728" checksum="A65845AD0257EBD3" modified="2023-02-22" version="1">MSIPTESIDGDMTADHDQEHLWPPLTNLGPSEELRLLRARIALLERQQMMNSTTSSCVSFDAQNANDAADTLCLQNDDIEPNNDKKAMADQQKEVEQTQADQLEILLTETNKKLEEEKQLNAELLAKIDELERKQKADQQKKHRAKIDERQQEGGRGGGGGGGFGCLNRDNEGGGLPSNNFSGGGGSGSDASGTRPNSILRIIIDTMPYPALDVLYRIFSRYGKVLRIITFNKGNSFQALIQLSEADSAQNAKNSLDGCNIYNGFCKLHIEYSKWSTLRVGQNNDKSRDYSNPIKFCGGGGFGRHNEGGGLPSNDFSGGGGSGSSGNDGFSNSGWGGGEGRGGARWNRWNDGRERGRGGGGGRFGCLNRDNEGGGLPSNNFSGGGGSGSSGNDGFSNSGWGGGEGRGGDRWNRWNDGRERGRGGGGFGRPNRDNEGGGLPSNNFSGGGGFGSSGQHNQQQQQQSNQQQQHNHHAHRQLHNSESARSCTSSLAGSVYDDLAAPDQHHHQQHTSSSQTRLCHRLGPSSSSFASCSITGHNNRSDSVGSTHSAASLPGSSLMSQKLTSHRVQQQSAADDGPHNSPEIIFVDDVIRNKCVPPIGHNTVKTELGEAELIGIEEDVPSGEPPVVLNSPRAKKVKKEEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4Q3</accession>
    <name>A0A914I4Q3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4Q3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7502.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7502.t1"/>
        <property type="gene ID" value="Gr19_v10_g7502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7502.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30759" checksum="88793CF50F7B9970" modified="2023-02-22" version="1">MPPLAACQLVACQYATCQLAQPHSSCKIAACPHSVHASCHLAACQPATLTDFFKLIMNFLPLLLLLFHLIVFLAVSKIGPIGSVPMPITSGLKTADKMIAVNRTKRNAPLSQREQRHQNGSEEEEEEEEEEEEEEEKEEKGGTRRAGGGGRIRKRKFHGDDDVGNGRRRGAKRPRAAQQYRRGAAYGRTAPYGEEPWARHVERRGTRRRPSRHGRHTFGQPSRIQFGSVAEHEPSAVERAHERAHHHAHGHANVWLLWLCALRCVLTMVENGASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4V6</accession>
    <name>A0A914I4V6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4V6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6905.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6905.t1"/>
        <property type="gene ID" value="Gr19_v10_g6905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6905.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20774" checksum="E638B6842D8D3078" modified="2023-02-22" version="1">MVLVSEFCAQLLSCQTKSLRDRLNHPEDRVLALNSVTGRKVRTTYKDRNGMSKTFFVGGITTKGAAFTPAYGRLCRPYNVNIAAHFYARHRIRIHLPYVPCIIERFPSGGEDRFYPMELLELVEDEASSNWIGRMFKEIDTTQQRASSSSTTDSALRFRIDEEDEENTGRDECSQPTYTCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5L5</accession>
    <name>A0A914I5L5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5L5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7534.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7534.t1"/>
        <property type="gene ID" value="Gr19_v10_g7534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09443">
        <property type="entry name" value="LIM_Ltd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7534.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11140" checksum="B6E82309F003FF25" modified="2023-02-22" version="1">MKEPCFRCKRPTYFNDKVGPLKDGVLFHKGCFKCWICGSRLSLKTYHNNRNDNQDLEVYCAGHVPTPGPHDAIPYRSNLLWSPKTKGEYPHNLMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5X7</accession>
    <name>A0A914I5X7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BRO1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5X7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6917.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6917.t1"/>
        <property type="gene ID" value="Gr19_v10_g6917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6917.t1"/>
        </source>
    </evidence>
    <sequence length="962" mass="109857" checksum="A8D8769E87216C48" modified="2023-02-22" version="1">MEGIPRVPMVAPEMKVPSHPFPDKLRSRIKSYIAEHYQADPDQYDAALDELEQMRTMISRCHTDVESICVAKRYYAQLVMMKKRFPMEEHDVLAVPFAWTDRMLDLMNQLCYEDVNFEQCCVLYNIGSAHAQIAASETRTEIDSVKNAFMHFQWAAWPMQQLRDQLGAARYSTCDFETPYLTFYLNVLLAQAQECMLEKSMIDHRKPTVVARVALHLYNIYQQCDEHLKSSGLADLLSSSKYKEVERLCGAKSHLYGAISSYYLGQQADDEQQYGTRLAYFARALAHIKIAVQLCEKERPKSALREAVQFAHDVIVQRESNVRKENDVVYHERVPRPEELIKLDGVAMVKPIGFDPCDPSIGGDDLFQALLPIDRQLLEKVSRCDSELENYLFSLKLDQLALDQPIDQQIRLPDELLAASAAFSAQPDAFPDLLDNFQRVTSTAHQADTQLTSLQHRMHAITNPFFVRDEGYLAIARKLDELNDHHKKARENNAELQRAIAAHSENLKLLSQPLPELTKQICGCDFSNNPGDSSEGMQLRRITDKVDEMRKQRCKLVDAFRTDVDADDITKKALAERELDPRKLFEQELHKHDAQRELIEQNLRAQENIIRALTDANADFADFRRQILETNEKRALHALTLVTAYQVFTDIVQKSGQAADFYAQLHKLLGALERGIANIETANAEFAREEQRKRHAQEERRRREAEVRDVRRRQEEASHEAARAVNEQHIAPTVAFSPGNFSTPFLPPIVPKSASATSALYPPFFSSASANTLRFRRRSAFSRASPLPPLFLSVLNDVKNDEGEEEEEEKPISGSSAISSNQRKPLRRPLITEALQPNCQPAEVFNEDADVEKSLTFDRAQGLLAEQRSPQLVCKLDVVRCHRMANEMMNELLDRLQQKNLPKQSGGDEENTQKQNKKELAMAELQRDFFPYVYAKAERLFVHRMANSFLDGTLENSAASKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6A8</accession>
    <name>A0A914I6A8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6A8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7162.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7162.t1"/>
        <property type="gene ID" value="Gr19_v10_g7162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7162.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10494" checksum="39512F22AAAD5401" modified="2023-02-22" version="1">MSFLDLVSRPPNFRRSYQVNHNSKQLIFHTLPQIWEVARDGTRPQAEDGGKGSKKQRNLFFNGRARECVKTDGRDGRTTIFCSTFFLEDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8G3</accession>
    <name>A0A914I8G3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8G3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7609.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7609.t2"/>
        <property type="gene ID" value="Gr19_v10_g7609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7609.t2"/>
        </source>
    </evidence>
    <sequence length="344" mass="36977" checksum="41AB5F5251A88AAB" modified="2023-02-22" version="1">MFMGRERRRSNGGNNGANNGGRTVPNGIGGTNQLSKVVRASSMDQIRMGEQQQQNNEEWLSQDELMGCSSDELDKLSMCLSEVGESVPKFGYEEQSLRPLRAFFHFRLSHWIIEMAPSGLANGVAVSRSASFCNEASSENQDRRRPSLFSDIIQAQLALWTLVITVFYSYAWQQHRKKFLLSLFVVVPPVLLLICTLSSLLTAIVILGRLFSSPVRFHDILRVDDGALDESEGGSASGGAFASFGSGMGGARRRTASGSLSTSCQSCGGGSVGRSLSMSCEELPKPMCRKHSTNGSSLSLYGGNGFGSATAGGGAGLVARSESIGNGCQLQRHYQYAHFSSDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8G4</accession>
    <name>A0A914I8G4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8G4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7694.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7694.t1"/>
        <property type="gene ID" value="Gr19_v10_g7694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="132"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="390"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7694.t1"/>
        </source>
    </evidence>
    <sequence length="460" mass="52837" checksum="93D796F6B5F51CE2" modified="2023-02-22" version="1">MSDECLPTIGCTVINSARTGGDDKNALTFEFRSVEGCTVQKSLADLERIFERFRNALPPGLEKMPKKKFLVAEQKLLEKRKNWAEALVTHLVAKHSDNYEVQTLFGALLSQLDENHVILGPSEKKTARPANFDYLKTVGQGSFGKVYMVRYHGDGKIYAMKVLGKEHIKRRNEVKHVMAERNVLLNNIDHPFLVSLHYSFQTRDKLYFVLDFLNGGELFFHLQKERCFAEPRGRFYAAEIASALGYLHAKDIIYRDLKPENLLLDRHGHVVLTDFGLCKEGIKMKETTSTFCGTPEYLAPEVIRKKPYDRTVDWWCLGCVLFEMLFGLPPFYSKNQNEMYHKTLTQPLCVPASASSSVSKLLVEMLQKDRSERLGAKSDFEEIRDHPFFALIDWEKLLNRETKVPFVPKVRAETDTLNIAREFTDIEPNPASLVPSHTFVNREMEFAGFTYNQKPTLHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8V2</accession>
    <name>A0A914I8V2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8V2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7976.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7976.t2"/>
        <property type="gene ID" value="Gr19_v10_g7976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7976.t2"/>
        </source>
    </evidence>
    <sequence length="277" mass="31334" checksum="DFE4BB87AD17ADAB" modified="2023-02-22" version="1">MLVDEKSITDIAIQKFIEITAFAKIEFTFDNQTHHLLIKHVAPHSSAAEETGPLAQIVVWKWVAGTQAIQEDLILDKGGSISFECIASSVIIRILKKRPVIENPCLPLSSPGDDFTVHIGIRQVTLSASWLMTVSPMFERMLTTKMKESVERKVTLDDIVPGFTMEQFELFLGYICRNNWRERLPDPTTVVGLVPVADYFQIGWLKERCDAHLVNAVEIPLADRLLLAERFNLSKLQTFFLQSVSVVDLKKIVKPTLPRLSPPTFLTDLTDRLCDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8Z0</accession>
    <name>A0A914I8Z0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8Z0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g860.t1">
        <property type="protein sequence ID" value="Gr19_v10_g860.t1"/>
        <property type="gene ID" value="Gr19_v10_g860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g860.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16791" checksum="80B9D2D59F6972A3" modified="2023-02-22" version="1">MAALQDDDLPPILDGPFSPARNGGPAETNYSDGVKPFRLADCLQILERVARDYDCIYPLPKLGTRRDHHVGCCLLIRSLSSANRLYIFEWQECIELKGHLEMEDGSSKRVLHEFYEKYDSLEGFNRFLRECLFNFFYLLYSAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I914</accession>
    <name>A0A914I914_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I914"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7751.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7751.t1"/>
        <property type="gene ID" value="Gr19_v10_g7751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7751.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="45597" checksum="68343E1225CD64D6" modified="2023-02-22" version="1">MNDNAHFTPQQLSKLINLHIKSHQCIAAKCKDERQQLLNTIEKLARHFYDVYKIHEKQKREMNRIVNLHNDFCAQFGLPSKVETTKQHEFNQIDKIAHMIYEHFIKVRDVNRKNETQQTDGLKHSPMNINAQSRNLSSSNMRRKKASSSSSIMAIDHENPKTANITMSNGNKIENAESLRGTNNEKRSSIIVNYGSIPATNSSLSPPDGVIEHQCPAQICTVSSKITSNFVGERMQIGNLLSAAATNGQPSLLYEKRLKRPISPVNGFVPNKIRVVESQQNGAASFATPSSSRTIGLTQRPLFPLNVAPADSGRMLDTSRILSSEIANSCNSLHGGVSRANKKKTMCQHFVGPFPKAQHPPPNSVNAVGGTVLITEGRELPIGLLSALQPPTGKTNNDKQSTANIVIQLDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I999</accession>
    <name>A0A914I999_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I999"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g808.t1">
        <property type="protein sequence ID" value="Gr19_v10_g808.t1"/>
        <property type="gene ID" value="Gr19_v10_g808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g808.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35241" checksum="AB09FF90EADE68A9" modified="2023-02-22" version="1">MGDEFDLIRSIYTFCAWCSFMLSIVFNTILAWLIIKKTPAPMLIYSKILMAPCILDTLFAICTFLVQPIPIVSHGYFAVIQNGFFQKASGFYNYSANVLWFQMLILFVCCTTIQFVFRYYLMISGGSRVPRRLKYLTSLIIICLLVAHVLLHFLSDFPYAKYSDKMLDLARLVNAEIGLTNIRFSSFTPARTYLWMFHSAVMLSIFAICYTINVFYSIRTSKYISKTYENTVIITKSTGTLVADLRKNERLSEYNKAITTALIVQILGFGLFIKPYRMAFLQFVGARKRGSVSGPAGGTHQQPARVQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA28</accession>
    <name>A0A914IA28_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA28"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8077.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8077.t1"/>
        <property type="gene ID" value="Gr19_v10_g8077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8077.t1"/>
        </source>
    </evidence>
    <sequence length="522" mass="54373" checksum="655526889105337C" modified="2023-02-22" version="1">MQLDDYVGFYKGSYAYSSWGVFWGHAVAGCQRNYRGVPFIFGKPMFGAGDVVGCGLNLATRQIIYTKNGERLGWLQNLLLSFLFNCNFKFIAKCPAGQFCKFKGWIKPDPDKKLPQREVTEFGNFGVWEFYELEYAKPPKAWADIGVITFFGAVQIGCGMFFVYIGAQKLSETFLEGGFNDIAEAIKATFGYTVISWDKYAIDKLLTYCPLFTDGLKQLLSGKAGMSMRDLNKIEWMLHQGIKVLSGEKPDGPIQHELKNMECYDKAKEDISRLISTGAQGMFGYGNGFMKNVEALAKAFTNECADWPDFGASASNQPNANGGGASASNQPNANGGGAGASNQSNANGGGAGASNQSNANGGGAGASNQSNANGGGAGASNQSNANGGGAGASNQSNANGGGAGASNQSNANGGGAGASNQSNANGGGAGASNQSNANGGGAGASNQSNANGGGAGASNRPTDNDVPKLAINCEYVGIGPNGEEDMLARVSIVDTDERTVYDKYVKPVGGISAIYFKQKFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAC6</accession>
    <name>A0A914IAC6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAC6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8357.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8357.t1"/>
        <property type="gene ID" value="Gr19_v10_g8357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8357.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23768" checksum="16BBC351CDDC0EEA" modified="2023-02-22" version="1">MSEFSGGCRLFTFSIVVKLSAGRRRRRLVTKKNVFVSSSFVFGVPSGRAKEINGPTSKRPPRLCFLLPSAAAGVEEAFPLGGWKNERTERVELTPMLGGGERRVSPGGRQKIRRRPGHPIAFPLRGNEVNPSRGREASSTDRRGGLMYDQRKQIDVNLCGGNEKKGRAKKIPVPKKHKIGCRDCESPSFIQTSNDSAKRMPAGPFFIPINAQIAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBB7</accession>
    <name>A0A914IBB7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBB7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9009.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9009.t1"/>
        <property type="gene ID" value="Gr19_v10_g9009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037148167" evidence="1">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9009.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20928" checksum="BF07F6C036E0CBAE" modified="2023-02-22" version="1">MLALWQTVSLISAILCITLGLKPSDLRDCFVGKLHAYKAFIQKLNGSLSKTIQTKKTWARHFNRVSRLLEAWAEHRTSEGGLTPGGAEHRTRLRMHFLLILLIAFASERRCTTHIKPTMAEFAWCADQKISITDEQFVFKCNTCWDLQEPNVDEDEQIVPIVIDEQARLYMTKKPSVDNPKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBJ5</accession>
    <name>A0A914IBJ5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914IBJ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8369.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8369.t1"/>
        <property type="gene ID" value="Gr19_v10_g8369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8369.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29185" checksum="56A0D2D27D38DA1E" modified="2023-02-22" version="1">MFPDEPHSQFTMISQIGSGSFGKCFLCKRVPDGAHVVLKKVTINDESKNEARLHSQISHENVVCTFESYLSHRSIYIVLEHMAGGNLHEHIKRHEEKPIDDMEILNLTAHMTAALTHIHQLRIIHRDIKPRNVLLSADMKTAKLCDFGIAIKLPQGQRAKGRFGEAGTINYMAPEILEGREYDFKCDIWSLGCIVYELVVRKKAFPGCQELAVFHKICSGIITYPLDSPSKLIGLIKKLLTASEDARPSAPEVIALIEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBU8</accession>
    <name>A0A914IBU8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBU8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9164.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9164.t1"/>
        <property type="gene ID" value="Gr19_v10_g9164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9164.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32533" checksum="A7135B565905F19C" modified="2023-02-22" version="1">MIFNKLSSNSTILGNLFYDTYKNAGPSAGLVTMAILIGLCAVPGNFMNLFLVYLTVKHKCLRGSSNYLLALNSFYEFLHQTGHYIFLFTILSGRNFIPFMDSATFQLQSVFGYSAAIFTMIETALDRFLVVITPDLPVTGQLSDTCTPINLIYNYGLVVCIITFVLYVQLALIVWKLSYQSPSSVRLFRSLSAICGLIVGSYFLNAIIRMIVVDLLDPIQLWYVNVAGSVLVNIGAAANAPILFLISTQYRNLIKTELSIFFAHSLNPRSMQSSQQVEPFHWPSQQAIRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICH8</accession>
    <name>A0A914ICH8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Parahox neighbor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:26301"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="4.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OHCU decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914ICH8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9568.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9568.t1"/>
        <property type="gene ID" value="Gr19_v10_g9568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051997">
        <property type="term" value="F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000255">
        <property type="term" value="P:allantoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017580">
        <property type="entry name" value="OHCU_decarboxylase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03164">
        <property type="entry name" value="UHCUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466:SF1">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="11">
        <location>
            <begin position="31"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9568.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22515" checksum="89E84725C216A983" modified="2023-02-22" version="1">MKRSIIPFILIVYALFDYVLNLSMTIDDLNNSNVEAFVSKLGQIFENSPWVAREAYQKKPFKYVDDLFNAMIQVLMNSGREKQLELIRAHPNLAGHDMLKGNLSQFSTNEQANAGLNILTKQQMTEFNSLNFAYKSRFNFPFILALRDQNKGGICGILAEFRRRITNSEEAEIDESLSQIGRIARHRLETMFEPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICU7</accession>
    <name>A0A914ICU7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9660.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9660.t1"/>
        <property type="gene ID" value="Gr19_v10_g9660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037962843" evidence="2">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="71"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9660.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30589" checksum="34DDFABEE0BDC48A" modified="2023-02-22" version="1">MSEKRRISIVLIFLTLLLLNSACAKGGKDRESSKDPKIGVDQMFNNLETDVTDVKQLIKDNFSLILNQIKEIRAEIENLKKRVSNLMMMNGSMSGEYEHHQALQNERRRLTKSKSVSIEHYQQLSHNTNSKYNSDGTMSDEVFMSKKFWPLFIGLANKGTMSADGWVGYAPGSYAYSSNGDLFGHNVKGKIRPIFKKIKFGAANDIVGCGVNLMTKQIIYTKNGELLDTANLTVSSTDLFPCVSLLRPGDQIKANFGPNFAFGSLLEIQMKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IER2</accession>
    <name>A0A914IER2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IER2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g922.t1">
        <property type="protein sequence ID" value="Gr19_v10_g922.t1"/>
        <property type="gene ID" value="Gr19_v10_g922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037340541" evidence="1">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g922.t1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37591" checksum="7FC44E602923730F" modified="2023-02-22" version="1">MILTFTLFVALAFSSNCDPSEEGGGPFKFVGTVLPQGNYRIFVRTLPSKEMEEILRTYDNHIDKSRQEWNALELISDLKWKKVNFENAFGVLGDGTITDGTKFEIQLDWKKRHDPYLEREFDPIYVQIYAVKESKKTSLMERILFNPSSEVEYEFIYGTPRDQIGVKKFLLGHFPKSTKNMQTYVSIQPHMNSNGIYQVADMDGNFEFVFDKAGTPPKEFKLSVYQVRQLRNTDSPLFTQKLTNPTLTQMVQNGEDLSRYRYKFGKNEVGLMEAKEKMVSLYQAYLERTNTKLQKEVRYQIPDEIGAYKLQLQMVHLKPLKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEV4</accession>
    <name>A0A914IEV4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IEV4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9583.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9583.t1"/>
        <property type="gene ID" value="Gr19_v10_g9583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009126">
        <property type="entry name" value="Cholcskin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF75">
        <property type="entry name" value="CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01822">
        <property type="entry name" value="CCYSTOKININR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="67"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9583.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52719" checksum="519EBDBF18D55451" modified="2023-02-22" version="1">MFFNNSAINNQTKFGQNITEIDFNDENLRSMLDELGMMNVDCVFRPTFDNYLMIFAFCVIFCLSVVGNSIVVVVILQQRSMRSVTNLYLLNLALSDLLLSVVCMPPTLVSSLVYCWVFGDLFCKLLAYLQPVVVTASAYTLAAIALERYYAICKPLHSRVWHTRAHAMFVISLVWLVSVIANVFMLFMYEERTYNRNGLNCAPKFEPIVHFGYQIYMTFVLLVIPLVTMTVLYANVIATLKGGIRIDIAAVEIGTNINNNSIAYENGTNAARNSSDKNTTVANCSKTKVLTWHQFLRKSLRHRAETRDSMTVNEWKNASWGTSAEQSLRSTHSGRTAMAKQRLIRMLIVIVVIFFCCWTPSYIWWLLLNAQDAFGSFNIWNSELNTLITVLTYLSSCTNPITYCFLNSKFRNALVLTFGCRSKAPTSRFQQPQFNNQSNEVAEYIEIYEKERIKTRGRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFZ0</accession>
    <name>A0A914IFZ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFZ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9553.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9553.t1"/>
        <property type="gene ID" value="Gr19_v10_g9553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9553.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38542" checksum="51AC8BD730FCBBD0" modified="2023-02-22" version="1">MECLLNDECYNAHYNCNIYNPDSIPRAKRQNIVPGVTLLICYVIFELLYVPCVVVFAQKKNIRESCYKLMLFMGLISMVNIHSGCLLIGIYAIRGDVFCDRPLFNYIVGMAVFAFYTCECIVSVILAVNRCIEMINHRLAVALFDGAKVYIWIGASIVYGLFMGFMFIPPMANGMMVGFFWQAHIGYVEDTEGWYQHKLFPIHNFSIGFSIPIIYLILYFMLRKKSMTIVSSTEQRQQPNSERKRNKKIFFQVMLIGFLTMLFAFLYVYIEYFPVSPWFIVFAHFSWASSQGIFALIMIVLNSHIRHSIKSVFIEPTLSRFTASRVNSSAIHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGJ2</accession>
    <name>A0A914IGJ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cleavage and polyadenylation specificity factor subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g97.t3">
        <property type="protein sequence ID" value="Gr19_v10_g97.t3"/>
        <property type="gene ID" value="Gr19_v10_g97"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="13"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="479"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g97.t3"/>
        </source>
    </evidence>
    <sequence length="1474" mass="164747" checksum="8C0425130A6B3347" modified="2023-02-22" version="1">MYSLLHETDDATSVNFSAWGNFLAGSGNQLVTVGSKCVKIYRLNPFFVPFGGADPSTRLECLLSFTLMAPVRSLAVVRLKVNPVCHALAMTFDDAKLSIVSVNPATMTLNTISLHSIEDEFLRDGYTDENIHQPELRADPDNRCCAFTVYGRHLAVVPFSIADFVQQQQTAKEDVGGKQHQLQQQMLLQSYTVKLRSLDEGLDNILDMCFLHGYYEPTLLFLYEPIQTTAGRASVRFDTVAILAVSMNIKDHVHAVVWHFAGLPMTVARCVPIRVPIGGVCLIGANEIVYLNQSVPPRGISLNSCADEFSRFPLNDLQHMRLSLDGSAIQALDSPPNDLVIVLRNGDLFTDHQSIRHVNTLHTDRFAVEQPITKYNNTDDSVHCAMLFDDDDNYLYGNDFCNSFHLDETLPTLCARRYNFEVVDSLTNIGPCKWLRTCSASFVSDVFLKRPRDIFFDMMTVSGHGKNSSLCFFHCSIRPQIIASTVLDDALQIWTVGRHRHVHEMADGEAHKFLVISRERSSVVLELANDNMVELDTPCFCQTETTVAVGELAHGAIVVQRTVTPTTVLLVSTIAAQQLEVLTVDSNFPVISASISDPFVVLLTLNGRFILYRLNNTSSHAAHLQQIPVLEVLRHAKSPITAICMYRDESGLMELCVDNEEEEAMDQQQPDNVLQPLALNTRLFASRSTDQDSIDGMKQQQEASAVESSIYGLNVDAFLYGDDDVDEKSASVHHPPLLPCTGNILPSTSGSTSNLNNGPAHDSSTCFGVQPPDRVKPTYWLFFARENGNLYVYSVPELRLCFIVKKLSHAHEVLYGDAQTLLEDDHRPAQHAFLMNTPVILPQVQSTETARVIAGGAGAESMMLKPEEVIFELFVHGMGINKGRPVLSVLVDDQMVFYEMFRHDDHIAGQLSIRFRRLPSTVVVREQRFLGPNGRAPVEAARDAEQRQRSYICPFERVGQLSNGLFIGGGYPSLLVCEQSGPCLRPMTVDGPLASFASFHNSSTCRHGFLYLTRNEHLLRIATLADKMDYGSCGGDLCCALRKSPIEQTVRHCVYLLQPGIFALILTEQQPNQKQCSVVNEEKQMETFERDDNFILPSLDSYTLKLFSTEDWAFVPNEVFQFDEFEVVTCCEEALLNSESTVSGVQNYLAIGTAINYGEEVYVRGRVLLFELVEVVPEEGRPTTRHRLKTVYDKEQKGAVTSLCAVNGFLLTGMGQKVFIWQFRDNQLNGVSFLDLHFYVHHMTSFRELALVCDLYRSLSLIRYQEEFKALSLVSRDLRPTAPAPMTAQFLVDHRQLGFVLTDELANVTLFNYLPETKESIGGERLIIKAALNIGSLINSIVRVKGHGAECLVDAKFQQGIQTCFFATLDGSLGYIRPLTEKAFRRLHMLQQVMNLHVPQPAGLNSRGSRAARPQRTGTHQQISLAKNIVDGLLVMQYLHLSVQDKTDLARKLGTSRYQIIDDLTELCRTVTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGZ5</accession>
    <name>A0A914IGZ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGZ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9819.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9819.t1"/>
        <property type="gene ID" value="Gr19_v10_g9819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="134"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="272"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="310"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9819.t1"/>
        </source>
    </evidence>
    <sequence length="497" mass="55669" checksum="651FAE2F128EAE29" modified="2023-02-22" version="1">MINRFIRNFLNGQHIICKVQQIQTVRVVFLHHCNKNVCPAAVLSCGACMASSSSSSNRPSNRSKLLDAYRNKRAANLQLTDLGKDAVAFAQDPLGSRFIEQKLERANPTEKAQPQINMATTLQENVPTLVTDKYGTFVIEHVIEHGLPEDRERIVRSLQGDIMKYSQDKFGCLVILKCFVCGTADQKKALFDNVCVGGPKTLQNARQLMADEFGTHVIRKFFECGTDDQKAQLVDALRGHVLELALQIYGGPVIQTALKSVDKASQIEIIEELTPRSCVIRCIKDQYGSHVMDTIFELVEPERLQFVVDAILSSPSDSVASLSLHECGYRVIQRMLEHCTEQQKRPVLEQLLDNVPTLVTDQYGSFVIERVIEHGLPEDRERIVRTLQGDILKTHYKSICSIIEKCLIFGTTEQKNALIDQLCADDGTGKTPLLQMMKQQFANDVVVRMVDGADSAHRDKMMFAIEEHIPALLKRQQLLAKRAGGAVVDKRKKPNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPB1</accession>
    <name>A0A914GPB1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Puromycin-sensitive aminopeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GPB1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10174.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10174.t1"/>
        <property type="gene ID" value="Gr19_v10_g10174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1172"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="15">
        <location>
            <begin position="238"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="13">
        <location>
            <begin position="474"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="14">
        <location>
            <begin position="774"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10174.t1"/>
        </source>
    </evidence>
    <sequence length="1273" mass="145622" checksum="E76E57EA1038A4AD" modified="2023-02-22" version="1">MGWATPDASVRWITWVFDLRHAPRTPISTTNWGNLAQKSAVSHISDRMRHWDGIDAVVGIGTNLFICSLPFCCCPQFASQLSLFWRHQQIPLNSSASSSTTTTTSFCAPSTGTSSAERRASSATTFNCSIASSTVNECAVMIVRRQSEECTTTTTSVLTDRGNEAGTSVRRSSRKWFGCCCSFRLAIVVLMPLLPIAVLLLCYLLLPSSVDRSEKPIAKDKSPILEDPLIRLPTDVLPIHYELHLKAYLPYRPAQLDFGTKNMTVDGHLRLLLLCRAPTDVLMLHAKALSIEHAKTAIWPDEMRQPGPRVIGCKELAGGNDLLELKLDKALLPGRKYVLEMDYKAKIGKAHEGGLYSGSYTSEDGEIRLLAATQMQPLDARRLLPCFDEPSFKADFSISVQHPEGTTVLSNAPLAHFRRVERGWSLSLFERTPKMATYLLALTVSDFKHKETSYKHVTIRVWVQPSKLAHTEHALEVTVRSLEYLEDYFGIPYPLKKLDIFGVPFLRVAAMENWGLIMSRQQNLVYTEGVQAKRERQFVTDVLAHEIAHMWFGDLVTMEWWDDLWLNEGFATIMGMKAADYAENSTSRTSQLFYEHTVKAFRFDQIAHQAHALSYKIGSVREVARRFDRITYLKAAAVLRMVERTVGDQMFKLGLRSFLRLFAYRNARSEDLLWALSTTMETSNQRNRAALAIVNFSLGEFMDSWTYQTGFPLISLKPARNASLLIADQEQFFYLAPVAPNPSRWKVPLFFDTTTANETLWLLENGPVTVPRGVLIDSNAHGYYRIQYDNETYRALICTLLTNHTQIELATRARLLEDAFTIARAGRLPFSLVLRMGEYLPAEHSYLPFLVFNNHVQLVLLLLRNHPKIEIFRQFVQQMLEPMYQRVFSTNVPLNDLSDTMREFAMIQLCHFDYAPCVNKSLTAFAQLKNKFFMIPPELRGSIYSTAIRLGTANDFEFIRRKYFAEEYDSEKGRILSGLVSTRSIELVNSLINEFFVDKRAFEEDFYGFLLKFVKSPILNQIVEYMRHNFRVFANRIRHPSIMKVVLTYVTKWMQSERELEELDAFERENAIDLRDLRLLAYLKELRMEIRANIEFVGRGAVQIFDFLDQRRDRKTAADDVDEAKTADTPDWCQWRDNRHEESFVLSWHHRQIAEFNFSQKSLLLCKIHMSYMRFIIPPALFVVLLAFVVLLDATGMPKSGMCCCCNSAPAAPPPPSSCCGRRKRQGVLSELMEWERRVSCCTATGRKRRAIGAPVSKRLEFWALNHFGTKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPR1</accession>
    <name>A0A914GPR1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPR1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10289.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10289.t1"/>
        <property type="gene ID" value="Gr19_v10_g10289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019420">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srbc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10316">
        <property type="entry name" value="7TM_GPCR_Srbc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10289.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35705" checksum="82FAE7DA24BB9963" modified="2023-02-22" version="1">MNNLILTVAEYLLLILFCSLSTAIAAFALFLLHKLNKNRNFNAAPSLIVFLSSLGVCCVTLTVQYTLFFLSTIFNTYLYSLVSPTQFIFWVGLVPSSLIPAAPICVFFLSLDRLLIILKPILYNSCQSIKQMVAAFSLISVISLFTMHLVFNLSDRPSTERPECISFGCLTSDDSRQFYALNRLAVALPNFLAGTAFLAALFSFRRRLERISGGSNNKGVPTNSNLTPTNTAEINNTDSRKMSDHLVFYCVLFELVLDLLPNFVYFLLTTFDVNVSVYVGAFRSMSYALCAFCSVFAHTAILWNIFKSAKIPPTLVRPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRP4</accession>
    <name>A0A914GRP4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRP4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10557.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10557.t2"/>
        <property type="gene ID" value="Gr19_v10_g10557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10557.t2"/>
        </source>
    </evidence>
    <sequence length="86" mass="9636" checksum="A02B15A3F25B5535" modified="2023-02-22" version="1">MDCPLEDCPLTDCPMMDCPPLTDCPLPDYPEAPWGRLYAAGILASLRERVAQLEKAVGRLVEERNRKLDELANNPKKALVKLDNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTN6</accession>
    <name>A0A914GTN6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTN6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1066.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1066.t1"/>
        <property type="gene ID" value="Gr19_v10_g1066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1066.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17300" checksum="ADFBAC8920C6F54A" modified="2023-02-22" version="1">MSARGIVDFLNKKCIPTTSERIYNVPSLPFFHNVTVGRLRMTFEAQKDQKMLGLLSIVESKQRKALDELKDRTLICENNNILMNASGEETAQELGEKSPTSPQHQLSDAKRPKNKLKKILSKMPKIDWTISKTKFGRLKKLAREEGDKPFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU92</accession>
    <name>A0A914GU92_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GU92"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1139.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1139.t1"/>
        <property type="gene ID" value="Gr19_v10_g1139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF485">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE DAF-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="548"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1139.t1"/>
        </source>
    </evidence>
    <sequence length="978" mass="109648" checksum="065E42242F742CFF" modified="2023-02-22" version="1">MGPKKFKAKFRREKGKKHLRNGHNNNKKPRQFLSHFLFVFLLLTLPPSPTVQQNLPSPMLLTVGLLGQPGLAAEQLLTMANQRLHELNLTNQDVYQISVKSFDMPTAQCPVGIDSAQGFSQAMDLLFTSNVSAFFGPICSDDLSSIARITSSMDIVQCNFRRDTWDDSVFDNILDMSTMSPENLATNILALLQMANWRKIALITCSQCYDATDQANSFAETISQVLVDKGVQLVDVRLVPTNGSLLNSTTVVQQLLPVKDKARVLLAILGNSLSDYIPFLRALIELAMDTNEYMTIACIERYSPSQLALPWLSNASKLDSPTLDLFDGTILLVNEFYQNALVSAFGTQTGADANESENAAQESLLMLSVQLYECFWTYALLLWRAFEATGTVDGYRNGTLLRSTIRTESIRGPFGLISMDNKFNRVAPFRVYLVQSNATATDQPRRGLVEFANISLSCSTGTKAANCAPTLSASILFAFRLPPDVPICGFQGELCDQRGTIIVAVGVMVAICLAFIIFLCFRKVKRGETTQMPYYVPEQQIAFLDMDYGGSSNISIHSFQQHMARREKEQQMDEFSEEIYTRKIATIEQSFVIIESFRLREKLSFDKKDTQLLFQMKQAVHDNINAFIGLCVEKPTELWVIWRHCFRGTLADLLFINCPIKRNDPGGAEDVRASVVSITSNHRAQQQQQRGTGGGYLPRRDILDNNFKSAFVRDIIKGLDFLHSSSIGYHGALTSTRCLIDSHWILKLSGFGTSRLLYKWRHNGALSNGIGNVVQPLIPNDELHYYAPELRSTIRSAVVRNKPEELEFSNDEGQAHDMFAFGAILYEILYRRRIVEETTDSNEGVGNFEAMEDDVGIFSAQAEERLPIVPEFPDEESAAGANSPRSTISCVDRVHPDLVALMRRCFSTTDQRPDANMARKITDATLKMSGSLVDQMIKNMEQYTGNLENMVKEQTGKVELEQQKIEQILLELLPKWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUD0</accession>
    <name>A0A914GUD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/potassium-transporting ATPase subunit beta-3</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11296.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11296.t1"/>
        <property type="gene ID" value="Gr19_v10_g11296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11296.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40716" checksum="A47FEE3AA64D397D" modified="2023-02-22" version="1">MRMVGERWRDKNERLRPLNGKANQEKHELKASKRQGLRGRIMTKADNGKFIEENNTLMANGRAKPAEKTSLSTFIYNRQDGTFLGRSAKSWAQIVGFYIIFYICLAAFWIACLAIFLATIDESVPRYYGENTIIGANPGVGYHPWLESNPESTLIKFNEKDKSTYEKYIKAIDGFLDKYNNSDGTRSCIGKESNSDHVKDGKAQIKNESCLFDCGFLNDNGCGETNDYGFKDGKPCIILSLNRLIGWAPENFNTSEIPAVIKSRYKKGSIAFNCEGISDPDKELAGNIKYIPPYGIEGRYYPYAKMLNYHQPFAVVKFSNLPLNRVVLVKCSAYAKNIKQDEESKAGMVTFELLRQQKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUV4</accession>
    <name>A0A914GUV4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUV4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11555.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11555.t1"/>
        <property type="gene ID" value="Gr19_v10_g11555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11555.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="36180" checksum="2BFAB6F514AC8DFF" modified="2023-02-22" version="1">METLVASDRFQRFYNCSFYEYESVPRMARKNMHVGIILLMLYAVFEILYLPCLAVFARRENILQFQMHCPGLYCAESLTAVILALNRCIEMWDNRIVRILFDGHRMYWWMAGVVLYGFVLGTFTIPPMPNGMFVGWFWNPHIAYFDDTEGVYQNKAFTAHNISIGFGLPLIYAVFYIIMHKKMSMIGAEGVQNRQRAAERRKSKANIFVQVLLIGILHMFCTLLYVYIQYFPVPSWVIMSASYAWIVSQGFIPVIYITFNKYIRRSIKRFFYHSPDGWPQNMPIPHSSRLPVRIPLQQKVSRIQLKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVL1</accession>
    <name>A0A914GVL1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit tim-16</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Regulates ATP-dependent protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GVL1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11743.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11743.t1"/>
        <property type="gene ID" value="Gr19_v10_g11743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11743.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="15972" checksum="019400BE2944C50C" modified="2023-02-22" version="1">MVWKELAKVAAAGAVAVSRALARAVREEFNSSREAARRSAAAADTSGADNGGTAPTSSTPPTAKSSATERRRAIERKTLLTNTRLGITLQESMQILDVQTPLDADEIQKKYEHLFNANDRKKGGTLYLQAKVFRAKERLDAEAHTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW38</accession>
    <name>A0A914GW38_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GW38"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11724.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11724.t2"/>
        <property type="gene ID" value="Gr19_v10_g11724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF424">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="72"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="651"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="727"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="911"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="946"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="654"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="966"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11724.t2"/>
        </source>
    </evidence>
    <sequence length="1036" mass="113330" checksum="3491EFE02369B2D1" modified="2023-02-22" version="1">MGEVAMVDKLFLDERYDFGDMFNDGGEDNSAAAAAGGGSTNLSMGLRRKSVYMDDLLVFFALESLGTLAIVGNCCLVVVLMKNRYLQRASFVLMLSLALADILHGIVTTTFFYPPILLRRVVVPPIGVRIFNILDWTAWSITLTHMSAICLDRLLAITLYGQYSQLITVRRAKLFTVTCWTAFSALNVVYILARFCCLISPLAESHFYSFGYGEFESQYERVHSALSGANMFKLTYTPLELGTLAVLSISNPITLIQLYRRHKRKMALKIRHSASASKSVAGSEAMIRRRYSLPPLLLLRGKRRHTKAHRTISHQPHQQQQNTASTMLLEMSMRMGSKHVSTEVREVATRRATRQQQRILFQISVVAIIFYLYMSAYYLLYHVFNVSNKWLVLFNSFFYSTTHMINPVIYFSLNKDMRAQLIRAIADCLNWACCVDDAAGGAGRFGGMHSSIYGRGSKKTQPGAESSSGASVLLHKSSYGGGCMTEANSSVHMDNAKSGWTLSPSRAGREESTVAASSPSLPMVHGDTGGCAFGRVGCLMFGKGRRCGGGGDTPCGSHTVVPVQAPEITTTGGPQCSGKAAPAVGGAMQRTTPEGTTAYRPPPPTTAKSSFGGLLSPTLGAISAPTERTALLTVSQSSFCNAREQSWHSELRHNNNNSNNNVHGQLNNNNNNNNNNNNNNNNNNNNKIYSTLLSSEQEKQRLACLAQTLANAVGTAVVAERHDDGVVHKKPPISADNSSMRACPRSDYSLPETDALQSGTASAASSSAVQQTSPARSFLMRESLQGSPFFELSGSVQMDEQPIAEQLELQLVESWNIDDQTAVGDDEQFVRHKDTLERLADERRLGTYLAERLAHGLERNERAAARTCRQRNSLLDALISALIASEEVEDGGSGGEQCQAKVQLNNKMRQLSTDQPTNGKKNGLLRSAAAEDGGRWSPALLCRKKSRSMDLSGQQQQQQPRVGAVQTATQPNGCVPNSESDSHGTGLYPLSTTSSSIGWRRRRRSCESRGYVPLRESECDPSGDETNEEEEDVVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWX7</accession>
    <name>A0A914GWX7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWX7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11155.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11155.t2"/>
        <property type="gene ID" value="Gr19_v10_g11155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="550"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11155.t2"/>
        </source>
    </evidence>
    <sequence length="867" mass="99633" checksum="299856D1AEC7ADDD" modified="2023-02-22" version="1">MTSRNICIKDKEYSALMRRLDGAKLRFKSQPVKITGIYLELAEYLKNSIFLMDKAEQNYEKVVSWGQNSAECSFDCSLAYRSLAEIAVEKGDFDSAINKIVSSLDFAYKTENPGLIQQALHQRAHINMSCGFPEKALSYAEECVKYLEINADEINKLKKDGDSNCRMAHLHNFMAAIYSELHFSNSLQQYNYDRMALKLNEKAINYASEHEDWSLLYRSLLMKLELTIGKERVSIAQMMCNIAAKIIPTKVDENKFKKESKCHLSLEKLRHCEQGNFAESKAMLWKRYEELKKEPDSVSQDLYEAVKNALVFIYKTDHRLKKANSMNVKNNAMRRCAQMAIFEKIGDEASFLGLNEIALTFYQRMLKSADKADDKRTAWCSMAESAKDCRLWSRALAFYKEVKALEEQLAYGDKEIIDTDIAIAIVSAEVEQIPLEERLDTYREVYKNCRTAEQKLNILSDYKEMLKGGGHAPVECTEADEFDALSEQQILFNIANEMKVVERNEKMVKERSNKNNYGESNLHEVARSGEYQQLKQLIDRGYDVNQMDHGGWTPLSEAVSTQNLANVRLLLMKGANPNTRSTEFLMDEEQNKIWSNTSNGGVFSRASSKDDDDWSALEYLNEFVLNSKTMDQSQEEKLRRFGELLKHRQTEEGFAFRSYEHFLELFEQKRASSQRNSHRKSGSSQRSFISEPNDQRRRKRRLSGTLSDPESDNDQRYALEKENKNAWIDEDDETEGTGKIVSRVWGIVTRRASRRCRRRRCCLSAMNWRQQRADFPRSDCFSNDFLYVLPVVNGSSSSGAWPQHLWQAPSPLHRPLQRNQGRNHSDVFENARGAMRVCSPLINAAIRAHGHSTDGVGITLPKPASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXE7</accession>
    <name>A0A914GXE7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXE7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11273.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11273.t1"/>
        <property type="gene ID" value="Gr19_v10_g11273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11273.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11996" checksum="68C1320A4E7478DF" modified="2023-02-22" version="1">MGERRVFSSRLANLWTYSFPTIPPAMESRTSNLSASIHRHGDYQLRLARSSAYVQAKVAPNLSKNLQKCPKCLVMVDIRLHAKCPADGLYQPYQWVLDPERWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXY6</accession>
    <name>A0A914GXY6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXY6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11810.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11810.t2"/>
        <property type="gene ID" value="Gr19_v10_g11810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11810.t2"/>
        </source>
    </evidence>
    <sequence length="522" mass="56436" checksum="282F8DAB88A40A6C" modified="2023-02-22" version="1">MRFNDAPFISLSAVLSGGGGPMTMAFGRPDVGIWRAAVYRHHSRHLRRGQQNWLPPPPAHCIIGRRPARVPPSPQFFEAPKASTNWKKPNSMRLCSSLESPQQSPTTTTSSISSTTSSASLRMSRESGGCGGGGLLHYNQRPQQFLTSNTAGGIGRSRSAVVLARYEPDVDGVNRYRHYNRPKPASLFFVPLTTKTPTDNGQSIDKTSPRRSNRRHNGGLLPAIVCPRSPGSKNVNGNAAGSKTFAKIGKAAAAFELGVDGGGHRLPQIRLKNALSASAAVSKTSIALVASSEIRTVRREGGDHQQQKQRHGEPGTKDVGKRRREKAEVTVRVRRRIIISDGSEDAVPSSVDHVRGTVAAMPTNTVTERRLNGTTAKSELVMKESIGTQTLVDEDEVNTNGTSTASAKATQTDAHALLLAHGATSAGSSGLSLISQEETLSLLAVIEDALDETIDRQSRIRTNEFIASTARKQAQIWRDAKEFVTLHLFPQAVELANSRTSGQFRRDTASELEQTLRNIQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXZ4</accession>
    <name>A0A914GXZ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXZ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11816.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11816.t1"/>
        <property type="gene ID" value="Gr19_v10_g11816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11816.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39306" checksum="D8F3DF0A3CA5D61B" modified="2023-02-22" version="1">MSDHPREAQRHLEELEELNICDDIWLDTLALIGLVEVGTKFALISARFDAIVAIHLRHRKWTIGTLYIQRARSGTGAEIIIQDDDTSCKYLPIANTPLPPNVVGFDSIYVCYIDREVLTFLRHIRRIISSNIALQFSIRATEQRCWDIMAQEIWPLMANGIRALMDMRKSDFVLLHKHISPTVLTDCVNLRRIFSHYLPNATLNDQRPGQDQYTWLQTPRDDGLPKVLSFYKWRKGWQQLTEQLKRNFFNVNTIPVNFLVYSCVPNGRIFLFDVVNDRTRERMAQSSRAGNTMFWHIHTNNAVLWRCPAVRSGHWAVIVSRAVQQMRRWETTTSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYD2</accession>
    <name>A0A914GYD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g1192.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1192.t2"/>
        <property type="gene ID" value="Gr19_v10_g1192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="379"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1192.t2"/>
        </source>
    </evidence>
    <sequence length="1497" mass="168411" checksum="207653B1ED837474" modified="2023-02-22" version="1">MHTNHGSAMKNKAGLATKRKNVQVVVRTRPLSEMERDERCKNVVSCDSVSKVVSLKTTGNEKNHGHRQFGVFDRVYGTESTQIQVYGDVVAPLMKEVLSGYNCTVFAYGQTGSGKTYTMEGRHDESGSYSWETDPTSGIIPRALHQIFTELSTDDIDFTVRVSYVELYNEQIYDLLSLSNTSQCESLRIFDDKSKGVSIVGAEEVIVRTRDEVYDLLRRGADKRRTAATMMNISSSRSHSVFTVSVMIREPGLINGEELLRQGKLNLVDLAGSENIGRSGATDKRAREAGNINASLLALGRVINALTTSAPHIPYRESKLTRILQDSLGGKTITTIIATLSPASSNFEESVNTLEYAQRAKNIKNNPEINQKITRRGLLKEYNEEIERLRRDLLAAREKHGIYLDRENYDNMVGEIEEKSAKVEDLEGQLAGQLQRVKTLLEDFAIMDENYQTVYNKCLAALDKLEKRKTEVEQLNKDLAQTKDNLNSANSALKVSENSFVRLRAQAYRLQTNCATFYKDLVGQREKRRLPIRRNIPRTNGKGKDRVNTANVSSNLVQSVSNIGKEVDNFNSLIDKTLNTFRIEAEKAQSKLQVFVSSCKEHMQGQLDQINHHSEIASDRLKTIDNIVAEQKDSTSSMLICLDTALYESQSTTEQFLNHDYKRFTATGVTPARRKTNSFMEDLVELPPSQELVRSQLQLCTPRRASFYRARDSILDSSDFFNTLVSPNTLKQNLQMTNLDEVDKLETIGENSERGADVEDGSVGVRQSVWANAKFPLIDKSVSKVLTNCESRKELFHCSFRPALGHLVALLLDSFGDDSDVNLRLKSGNLLCLLTNLDFAAESADFVAFVLPGVFSRCRQILINSLPNLRSLDLVRCACQLIINAICVSFSELGADCRPNFSSEEKAKPPMSMNVLSFRRDANWVETAARRILPQTSLLLSHLSSHSVDYIRYESLNILSQIREQISSECFGPQFDRLAIDIAVLLYRDHMHKTRKLARRLIEDVCRQKGDLFELHTLNLLKKAIKSFEKDVKNASDGGVYLDNFNNLVQIVGSTLLDRLFPSEGVSALPPMKYGLCAKQFSELASLIVGTRNSEKLFDWCFENFRINSSVEQRLSIAFFAYSLLDALKDGHQADHFVGDVLQMLASMDSVLEEEVLDHRIADAIVTNSAESSLIQLLLRCLSTFHSRADDMFSARLRVDVTYELLKWCSSSNFGVKNAAELALSRLAESHCHQNVSSLIQSDAQQIVFKLSMDSRDFAVCPRFPLVFAGMVSRCEAGPMLLPKVRSVVDELLLWLDRSDQKRTVVLAKALRAYLNALDEWFPSLAPQTVAELSKPDEEGRGVHFEQHFISSAHLPLLLKLRGRIVADDPSELAWPCPGKIVLAKAIEAVLCVCRLSKDFVYWKIVHEFMPRAETLLQILLKESQNLGKLYAQTATYKLQCAMLDSVPGIIEYAKISPQHFKSMEDIIAVYAQERKLPKKLRDRASATLDHIEKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYM7</accession>
    <name>A0A914GYM7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glucosylceramidase</fullName>
            <ecNumber evidence="3 6">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="3 6"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYM7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11608.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11608.t1"/>
        <property type="gene ID" value="Gr19_v10_g11608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038031078" description="Glucosylceramidase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="8">
        <location>
            <begin position="107"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="8">
        <location>
            <begin position="246"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11608.t1"/>
        </source>
    </evidence>
    <sequence length="490" mass="55576" checksum="57398351E7CEB5E0" modified="2023-02-22" version="1">MKICKLFLPLFFVAAQFVQVLCVAEEAGKPCRKRNLGHDSFVCVCSAEYCDSPDPPGDVSGHKMVYYVSDKLAHRLAKFENDDANRQNANNEFEVRVDASQKRQTIFGFGGAFTDAAGINLNALSGRTRDALLKTYFDQKIGIGYTVGRVPIASCDFSTREYSYLDTPDDFNMTTFALAKEDFEEKIPYILKAGQLAGENRLRLFASPWAPPGWMKSNGQMSKDGQLKGTVDGQYYRLYAQYLKSKIQRDFASQILVPMLKTSAQTEQLKIIAHDDQRDILLESAEKLFSDQNGLNVIDGLGVHWYKHSSFAALTLTHNLYPDKFLLATEACHGDLPWEHRPLLGDWLRGWAYGHDILNNLRNWVVGWTDWNLCLDLKGGPNWVGNLVDAPIIVNATSDEFYKQPMFYFLAHFSRFVPPNSVVLSTSLFTSNGTQLEDSPIENVHSNTAQLLPPTNTLNMSPFKLLTAVVCWRHFEIVREKERERVRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYZ3</accession>
    <name>A0A914GYZ3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12419.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12419.t2"/>
        <property type="gene ID" value="Gr19_v10_g12419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="15">
        <location>
            <begin position="240"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="TAF6 C-terminal HEAT repeat" evidence="16">
        <location>
            <begin position="420"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12419.t2"/>
        </source>
    </evidence>
    <sequence length="689" mass="77243" checksum="EEC21C7C29356AD2" modified="2023-02-22" version="1">MASKEESNNEKEEPIHVNKWDGANVKNTLDDTVRKLIKDNYGWTERHTLANGRLALSFLAVAFAGFALLYDYLLPFPKSKIVLAVCSISYFVMIMVLQAYQWYVEKFTFFQAIEVVDDKSPPRHWKWSSDMKRYDDKYVLIAEYSQGTRSGSMKVVKSVAAYITEEGEVLVPLVKKEVDLLKKNLLNFFDHHFLFNRVPVASAECSMDVEGHAPTPSTSAATANELALPADLAAFESNFVSVISEQLSTDILPSSSNAIALHVSSLIRNVIRLARKFQRSARRKWLSSEDVEAALAYYGHSALIGYESIDDVGFRHVGKMGRELFVREDPELDLGVVMNNPPPKLPLEVAIKAHWLAINGVQPAVPENPLPLMPKDALPMANEEDRASTSAGVTSRTLLLNQYMKSMRKTEQVQVKSTTTHSLSLEQQVFFLKIMEAIMGPSEDEQKRLEALNCLQTDCGLRTLLPRFSVAITEGVRCNIVVHNMAILVYLMRMIQALSQNPTISLEPCFHELLPAILSCILSRQISATQTETNTHCVLREFAADLLTQLLRRYRLPHIHTRVIRALSRAFSDSACSLPTLYGSVYALCQLGTDTIQRVILPNVGVIYQVISRVQTDKHYNSNERALADRLHAKMVEKLAVFATDANCDLPLLSRQNFLEHFGDFGDDVFAAVRQNNSSVINSNSGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0P1</accession>
    <name>A0A914H0P1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0P1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12856.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12856.t1"/>
        <property type="gene ID" value="Gr19_v10_g12856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12856.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12250" checksum="E385D63731B37BF8" modified="2023-02-22" version="1">MFLLKLLTFSSYQLFEEKSKIASIQLNLVLIVESSVDWRSMCHHKLWGWTSIVLLICTLLLIGGATALGGLRFGARGCQEDCDTLVQKQGFDLNTCMKCCALKRMGERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0T6</accession>
    <name>A0A914H0T6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0T6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12579.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12579.t1"/>
        <property type="gene ID" value="Gr19_v10_g12579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12579.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="28659" checksum="C580B98976C04164" modified="2023-02-22" version="1">MGRCRTWAGAEPRSVPNLDRPVPNLDRCRTWTGAEPGPVPNLDRCRTWAGAEPGPVPNLDRCRTWAGAEPGPVPNLDRPVPNLGRCRTWAGAEPGPVPNLGRCRTWAGAEPGPVPNLGRCQTWAGAEPGPTGAEPGPVPNLGRCRTWAGAEPGPVPNLGRCRTWAGAEPGPVPNLGRCRTWAGAEPGPVPNLGRCRTWAGAEPGPVPNLGRPVPNLDRCRTWAGAEPGPVPNLGRCRTWAGAETGPVPNLGRCRTWAGAEPGPVPNLGRCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H250</accession>
    <name>A0A914H250_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13436.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13436.t1"/>
        <property type="gene ID" value="Gr19_v10_g13436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23278">
        <property type="entry name" value="beta-trefoil_MIR_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000006">
        <property type="entry name" value="Protein CBR-LIPL-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000132">
        <property type="entry name" value="Ryanodine receptor 44F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000017">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000003">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000022">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035764">
        <property type="entry name" value="SPRY2_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4860"/>
            <end position="4882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5000"/>
            <end position="5022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5042"/>
            <end position="5066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5126"/>
            <end position="5145"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="19">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="587"/>
            <end position="808"/>
        </location>
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        <location>
            <begin position="1021"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1526"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="4263"/>
            <end position="4298"/>
        </location>
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        <location>
            <begin position="1330"/>
            <end position="1398"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1422"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1499"/>
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        <location>
            <begin position="4572"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="4626"/>
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        </location>
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        <location>
            <begin position="1343"/>
            <end position="1352"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1422"/>
            <end position="1436"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1445"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="4660"/>
            <end position="4671"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="4685"/>
            <end position="4698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13436.t1"/>
        </source>
    </evidence>
    <sequence length="5247" mass="593740" checksum="4A01288179B80D75" modified="2023-02-22" version="1">[encoded data, 5247 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2W7</accession>
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        <submittedName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
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            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2W7"/>
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    <dbReference type="WBParaSite" id="Gr19_v10_g12749.t1">
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        <property type="gene ID" value="Gr19_v10_g12749"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="PANTHER" id="PTHR45774:SF3">
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            <begin position="21"/>
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            <dbReference type="WBParaSite" id="Gr19_v10_g12749.t1"/>
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    <sequence length="172" mass="19114" checksum="B9E2A077A24FC8C2" modified="2023-02-22" version="1">MPKPISSVDRIKHLLDTGNEADVQFLVGKGDEKELLPAHKLILKASSDVFETMFRFDARNAKTAAAGTDPSEEIKPVEVPDVEVGAFKVMLSFIYVDDVSGLNGDNAIAVLYAAKKYDLPELVNSCLNFPIPELSNIFLAFDHVRSLGEEILDRDELIIRKELTIWNAVKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <end position="22"/>
        </location>
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            <begin position="23"/>
            <end position="159"/>
        </location>
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            <begin position="54"/>
            <end position="126"/>
        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13750.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17461" checksum="B7D9509A7B6F61DD" modified="2023-02-22" version="1">MDNFVGLVVLLLLIANAATILAHQYEFSQIFRHSSNAISSQSKDDLESQKSIQCCIDEAGLPAECAKSVCNYFNVKKYPDSCTVPIMHNFVKIVACFTAHKDNTECCKSKGVQAPCVDLCNGKNPDILPDPEYVPCTFPGKVDTAIQQCNHDAWTGNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3F6</accession>
    <name>A0A914H3F6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3F6"/>
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        <property type="gene ID" value="Gr19_v10_g1364"/>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="1181"/>
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            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
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        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
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        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
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        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
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        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
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            <end position="1084"/>
        </location>
    </feature>
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        <location>
            <begin position="1085"/>
            <end position="1095"/>
        </location>
    </feature>
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        <location>
            <begin position="1096"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1364.t2"/>
        </source>
    </evidence>
    <sequence length="1181" mass="128472" checksum="C255AB57D58D1F4B" modified="2023-02-22" version="1">MSECPFAAMNLHTPPQTLHTKIAPPVLNGVAVPAAPQPPQPHPAQHQRLYNSHTVVRRSQLLQQMVVETQEQLNVDHHPSAFHRVSSASAAAQALPPLTVEATGIAGGGAGTMPAGQIHQHHQHGTATAAQQHQYLLAMLQQQIKSGATGGANSDSNNNSTTTTTTTLNELLQQHHHHQKQQQQHQHIRMNTSGAGPGSQNDEQIYPQQQSLARLVEKRIHLGTTVDDREQQQKQHGRELVMAIVDSSGTPTTMATTTVKEEVQQQQQQMTMDQQQQTNVVTPRSSAASATPSMLTAQQQHNIHAQTHMLESPCGGCRELRREVEELRQMLFQLQQEGSASSGVRRMGALKPQSPPSPPHPTAFATAAVNHQPMQQQQQLLRPITPQQQQFRQNLLTQADNGNSETAMVPSQQFNQTGPQPNSNYNAHMLQLFLTHGAGGNSQQQQHQQQQHPPVPISASSSSAPASSAAMSVVASVASLGRILDQLGGASNSSSTSNILGTQQHQLQQWGTGVGGEKQQQQLLLSTLQVLQQATQIQQQNGPQQQAHGGSSNSTRNNSIQSGESAFFDPSSGIDVSETSSSASSTNTQMMLQSPPQLLDSAKPSLQLQANVIAPHLHQQQQQQIPHQIVQQNPQNTTLLNRSQIELLNAAISRTNAAVTSHLLSPAHGVVQPQAGQTGSNCNQNEMVRKLSTMQTLLVTLQQHQQQQNQLALQQRLQHQQQQQHAIVAAATAAAAKVQHQPGPKMHKRIGVTQQQRHAQQQHYGGQSMGMLSMSDAFGQRHSQHDGLSTMLSTAQQERAVHAPVERRRAASDDHIQSICSQTYTEEQIQQIQIPVLEAHSDPHFRPLSEQQVIQQVLQNKKHENQSVAETMAQLCKKLAEKRVFGSRLMAKTTFAMPNHSSYSNLPLPGIIYIYHVCQKVLFDRVGKENEFKEYFREAMRKLAARCRRVRHARKFHHKQPQGVELAPSVGVVVGQSPFQQFAGRPVIGGALGQQQPSAASGGPPAMGVQHQQDTTPTMAAVNAAIAELAHRRQQQQQMALQSALGNPLELSEMPPCSSGGGSLLASMVENGSASSSGLMAASSHEVERMEVEEAHLDDDEEEEDLEEEGHLSSPTISSQSTGTTTQQQSPEDGESSDGCARSSGGDSGTTGGTMDEQHNAQEQMDIKHEHSQQQSMGRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H428</accession>
    <name>A0A914H428_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H428"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13959.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13959.t1"/>
        <property type="gene ID" value="Gr19_v10_g13959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13959.t1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48191" checksum="3F2DFCB36F516348" modified="2023-02-22" version="1">MSDNTSDEDQQQQMEEIHFDRLDALVDVHFKSREWLLSWVCIRRATDGNGAQIGVKRSGKRFCELVPIPQGPLPSKVIGFEFIQICYIGQTVIEFLQRIRRLFDFSGTDVTICTSDNQSRCWGIIWQNIWPLVNGNICCLSLDFSQFDHLRQISPTVLRDCAKLRSIGSSGLFPEFPAEDNAGASSDQAVAKWLITPRGDGLPKMLRCDFWEGMEGLKGSFVNASEPANFIISIWIDDAELVPSELTNNWTGERLTLRRLNEDNWLLVRCPIVREEDKWTKWEKETIELDWDYQQEWNRIDIDFNDTDIGDGIVDENEGPKPLSVLPPRRTQNVQEAQDACLPVHAQQFLFKQKFAQNLLLPPRRIPPLPLLAPPPHRQASFPRAQYYQLEVLNFEQVQQQMEKRANEIKGQELHLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4S3</accession>
    <name>A0A914H4S3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H4S3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13981.t3">
        <property type="protein sequence ID" value="Gr19_v10_g13981.t3"/>
        <property type="gene ID" value="Gr19_v10_g13981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000007">
        <property type="entry name" value="Peroxidase mlt-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF61">
        <property type="entry name" value="PEROXIDASE MLT-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038046588" description="peroxidase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13981.t3"/>
        </source>
    </evidence>
    <sequence length="785" mass="85447" checksum="139157A03440591F" modified="2023-02-22" version="1">MSTVLQLCATTVAVVTTLLLLVTTIVIDGQDDSGYGYSDPNPPAVLGANGQSGGNGQHNSGYGYSDPNPPAVVGGNDQHDNGYGYSDQNPPAAVGNDQHDSGYGYSDPNPPAVLGGNGQHDSGYGYSDPNPPAVVGGNGQYGAGNYQFRAGNSKIRGQNSQNRNKAQFASRRGQGVRQMLRSCDQTNPSTTTDQLIKAGMLNPIEDYFSRQTLSLADIARTMNSSGCVPQISAGGDCSRELCYHLAYRSIDGVCNNLKRTVLGAAFRPYMRHLAPEYADGLMEPAGLTRKSTAREASSHLLANATAITHDQINSLFMQWGQFIAQDMSKTSRLPPDACTTCAPVANKCVPVPISDQDTNAKFRQKGCLTVPRSSAICGTGVHGTPREQLNENTAFVDGSPIYGSNYRDLLKLRDGRSGLLKMSRFNNMMLLPFDSSRCGTTIDTCTVKSFVSGDSRSNTFIGLSSFYILFVREHNRIARVLQKLNPAWSGDRLFQESRKIVGAEIQAVLYNEFMPLMLGPSAERLLGPYNGYEPNVNPSVSNEFTTAAFRFGHGMIVEQYSRLSDNWRPIPSGPYQFNNGTFKLQKLLFEGGIDPVLRGLWSTPIKQPQGMTPAVTEHLFSNADLGTLNIMRGKDHGMPSYNKMRQFCGLRMAYSFDELAEHITDPTIRRALSSIYASPDDIDLYVGGMVEDALMGALVGPTFACIIGNQFRRSRAGDRFYFENPSIFSPAQLTEFKKTSLSRLLCDNGDRITKVPSTAFLLPFAGGGVSACAELPQLDLNKWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4Z1</accession>
    <name>A0A914H4Z1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H4Z1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14032.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14032.t1"/>
        <property type="gene ID" value="Gr19_v10_g14032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="14"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14032.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34460" checksum="E361F201114AB0B2" modified="2023-02-22" version="1">MDSATCAPHSYHQININPTNYFLSLGTILFAYGGHSGFPTTQHDMKKPEDFTKSSILAFIVLTLLYLPVCLFGYFVYGNSLRDSVTSSIQHVWIQQLANFLITGHAIFSVIIVLNPINQTAEKFCKVPPKFGIQRVLVRAAVLGLAIFVAESVPTFGPLLDLSGGSTQSSMSLIFPPICYLFLNAAEKKMEMRRAWLNKADKKIEMHFESFKQRATISDVFNYTDVKMLFVCTFISAFGLLGGLAATFSAIRALTFTHFVPPCYISAFTSSIKEEVTNMGTINCCGAYQNISIYGKPENYCSEADLHFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7D8</accession>
    <name>A0A914H7D8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H7D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14889.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14889.t1"/>
        <property type="gene ID" value="Gr19_v10_g14889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="226"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14889.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="36057" checksum="52A674DA27135920" modified="2023-02-22" version="1">MFLQEEELSIVPERGYERCDRASVIAIKYLEWRSKRDNVDIKHVGNGREEQLWDFHPRMFKCYDPTAQLIGGRAAQDLYDETQERLAELRETLDVEEVWTCEIEQELKKDAEMKEFFEDRGKKKGPIDPRMAYAGGRTGPMKLFAKAEETKKISVYDIVSLYPAVNYETAYPTRLPDIIIPTRDEIEVSWTKPEDLKYKGLYKAKALECGYTVDRFYRAWHYGEDNDDLFKGYIDLEKVKKNAGLRYISKLMLNSLWGKFSMRNSLCKNKVIDQASEFYGLVCDHKIEIHDIVEYSDGAIRVVYKDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7Y4</accession>
    <name>A0A914H7Y4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g14559.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14559.t1"/>
        <property type="gene ID" value="Gr19_v10_g14559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036687886" evidence="2">
        <location>
            <begin position="24"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14559.t1"/>
        </source>
    </evidence>
    <sequence length="702" mass="79554" checksum="D8B172E421761FF0" modified="2023-02-22" version="1">MYHDILLLFFIKXLLLFYNGATADELQPKKEPGEIVQEVIDRFEKIAETSVDLTEKLALIRDTSAAFIKLAVPLGALLAASLDIVKKESPESEEYKALKKLNKQMNYQFDRLGERLTYSFEAEEMDTELRHFQNFITGQLNILSRKVRYFTDPTKPKTVSSVNDLLEYCKGANGVEKMADYINQRVTEGCMLTNTLVFVKIENLWLQIKQKFNITEWNHHEKHLKRRILKIIYSIPSSESLDELERVERNLPDFFSFKSTIEGVFELIKHKQSRNPTKCLTDAVFNGNMYDRVKMSFFSALIQIELGRLMLAANLCGNFTFNDNKAQFDQFLFEVTADVTHTSQFLVDYMPKKLNMSSMGVEDLIISKTIEDYPGGKDGIPSIRYYGLGAKIHQNLKHVGLPRIEKQVLVAPSENSDATFTAYYVCPDYWCTKVLGQRGVDVMVARFIKHHIFDAWSLKKRLQRIKPAILETLKLDYYVSLPRLVNELEEIKKLKLVAEWQQSAAIVRQKTAFLHRSCGHCAFRTFKLFGQTMALPNLTSFDSTLAGQAKPKTFTDNNNSIDKPQKSAQQQQQQQRPTTLFPISESPTTSFGTAQDTDQSKMIRPPPSGNAWWSTLCPGTIGCAIGKLFDQCRSSWQIMPLENATTPNAAQCPAALLNSRQPLLMLPPLPPPAGSTSPQQQQTSFGPALKQCGAAISKTSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8Y9</accession>
    <name>A0A914H8Y9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8Y9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14345.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14345.t1"/>
        <property type="gene ID" value="Gr19_v10_g14345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14345.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39747" checksum="FF2C33FBA021E3F1" modified="2023-02-22" version="1">MHKFLGAKSYVFFKKRVLELSVKDQEEEGQTKPDQLEHLREKINQLELELKDVKQLKEAIKEGTKQLKEGVTTKMEEYQKEQKQTNDVLIEKLKVSIDHLSSKHQEHEKLLNAQKNLMEEKIGWLNKDQEQCVQTTISDLEQKQKDDQQELLRKMDESLKSVQAMVVAELGQQNMELQSDQKALLDRLNGLEQKQTANSEQQKTDQKALSAAIDQGTADTAHHAVLVYFVCGKCGNVYRCTYDLFPCGKKYRWGYYGSYYKLCRDTKLRLFYEGVEDVFCGMWKNYNLISAACDDWARDFYNRVNDKSEEAAAECARLYINLLGSAAVCEQSTGCAVGCSRRAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB11</accession>
    <name>A0A914HB11_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15437.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15437.t1"/>
        <property type="gene ID" value="Gr19_v10_g15437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15437.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="9903" checksum="DDEDB25D2FA3CA38" modified="2023-02-22" version="1">MNSSEVISKKGKSLLTREGFDDQFEADSKVEDNMQICSNSPINLCPCVSPSRAIPHLCCGSTLAESVAETAMGELEMTHTAGAGGAATDRLDGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB94</accession>
    <name>A0A914HB94_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB94"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15510.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15510.t1"/>
        <property type="gene ID" value="Gr19_v10_g15510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15510.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32151" checksum="794EF6BB1ECBD210" modified="2023-02-22" version="1">MVMSRVCCCCCRRRVFNGEGLRRDRPSAADGTRRRQRDGSKAKLAKFFGIFYSMDDELEEDNNRKGQPEPIGKEDVETEPMIWRRRGEEAAAASSQMRQQKELADSATVPSTVSSSKCVMEAKGQHRFALKFEDTEYIVDVNSRGAAEREAEEGAVQQQNFRLYRRSHSLAGKVPPPALPNLLSSSPAPQIRPKMSVVGRVASLFVSDDSSAASSTAGGEGSTGGGTGGGGGTRRKRPSLLGMIGVGGQRGSRSVSAFIPALFQRQKSSGETDTVAESDAPGEEERQRRMVGDAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBT6</accession>
    <name>A0A914HBT6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBT6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15661.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15661.t2"/>
        <property type="gene ID" value="Gr19_v10_g15661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053287">
        <property type="entry name" value="PP2C-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586:SF0">
        <property type="entry name" value="PP2C-LIKE DOMAIN-CONTAINING PROTEIN CG9801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586">
        <property type="entry name" value="TIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="223"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15661.t2"/>
        </source>
    </evidence>
    <sequence length="970" mass="106206" checksum="6F691730F74C1F79" modified="2023-02-22" version="1">MSAFLRRRMRGLLRTTPNSTDTVSSIGGSDEQQQQQQQQQFRCDEVEEELMLVMKLNGQQQNGRAGRSSESAAVYERILNGRNGRRVESVPEVYSGKTGLDLPSIHLDKFTSEVKACHTGPDGGLTKVQPIRKRAIAAMANLDDEEFSLSSMDEDEATETNSNDRCQNGKRRAKTSLSRTQTDSFEILDIINLSRDGEKPVVSSVPRSSLARYDWNSWDEEKAYGLSTSLYEKHPVTALSAGHPIADVFGIVSRENNAIIALADGVNWGEGARLAARCAIRGAIDHLNAAIERGDTLNTTNDVFHCLLGSFHAAHALILQEGGALTTLCVALVAPVRDSASSVLCACNVGDSLCFVFNDEHGVREVTLASHDIGQMRDMRDAGGALGPVDGRNPQLQNLTCSMTFVRDGDLVFITSDGISDNFDPVVGKFCVIKRSRVDSSEKENVADGVEAAALPPKPAQFFHKTKSAPSANGLLHFSPFPPQHNQLRSMIKRPAAILPSVDAVERHELMLLRMCDVISNGEAQIRPSEESHRHAHRRAAARPCCPGTTTTTTNNENSRRPQSLSAAKRRTLEDPELYRTRTHSKTEERLRRKVIRDMIMEMPGKLDHASVVAYQVGKWPQPAESPTLRRRTTEWDGGMELDGVFVERRHAGGAGRFDENDANGAIVSCRVDDPSPASIWPTAAAICPAEENGGGDGRMLRQHNDTTQQRPVVEQTWQKTTLNAEQMGGRRRRHGRDSEARHTLGVDVSWLKRLVTSKHEQKQQQQLSGTNGNYSGEIVGNEQTHPPTSNGKCQKGTTISSAPVGVKKYREGGGSNFSLRKLRVFVRHQQQPVPSIEQQHQPPRSRQPSPREDGEGMQRQQPPSDQIVRHGNGFLLSDGIKSAAPSTSIICVQQSSAAAADCCCVDRAVFDDDGNVPQPPTVPRMGLGQLLGPVAADERQQNCCAAKIVAPMAANDDDEDEVVLKGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC53</accession>
    <name>A0A914HC53_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vitellogenin receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC53"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15747.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15747.t1"/>
        <property type="gene ID" value="Gr19_v10_g15747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15747.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16678" checksum="085D1BDDA41905E6" modified="2023-02-22" version="1">MGNIVYSDKLTCYENADYCANSCPASAQCVYVDNCGESSKAHYACLPFDTRLLTSVLVPLMWILVISFLLVLLCCSALVVFYAFRVIRRSFRNPVQTDGDIVFYNARNVHNFPHPAAMKQPTAVEDDGRHEYYYYNNNPRRNDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC67</accession>
    <name>A0A914HC67_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC67"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16001.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16001.t1"/>
        <property type="gene ID" value="Gr19_v10_g16001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="336"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16001.t1"/>
        </source>
    </evidence>
    <sequence length="535" mass="62426" checksum="D3F110A469B24236" modified="2023-02-22" version="1">MSISADSTNGGEITADQQEFWPPNLANLDPSEELRLLRARIVQLERQQTFNNLPTSSNASFDLVLKNGKRRKISALEQKQTANSEQQKARLAKMEEYQNKQQQTIDALMVSIDQFSSKHQTHEKLLNDHQKLMEEMKEQRKMADLEQQQHQKETNDKIGWLNKDQEHCVSVDQFLLVQSDQKALLDRLNALEQKQAAYAEQQKADQNELSSTIDQQCNEREKQLNNFLGQFIEGQNKKFEEQKEESDRMLHKQMNEFENSSKKELEKGMNQLKGELIAKMEEQYQKEQLKMKQYQKEQLKMEQYQKEHKQKMEQYQKQKMKQHQKEQQQKMEQYQNKQKQKQNTNVLTEAQMPQQNRLKSAACHEDLTFSGTDRLIVQFTGENSTWRSVFAERPIPKNNFGIFYYEVAILEQGLYGIHIGLGTKQKPLNRWIGENEGSYAYERYGRFYGHAVEGCSHTTNGRPYIGGKPEFGIGDVIGCGMDLATRQIIYTKNGKRLESTGLFVSFFADLFPCITLFHSGDKIEANFGPNFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCE3</accession>
    <name>A0A914HCE3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JIP scaffold family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g15815.t3">
        <property type="protein sequence ID" value="Gr19_v10_g15815.t3"/>
        <property type="gene ID" value="Gr19_v10_g15815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1000:FF:000001">
        <property type="entry name" value="C-Jun-amino-terminal kinase-interacting protein 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032486">
        <property type="entry name" value="JIP_LZII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16471">
        <property type="entry name" value="JIP_LZII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH1" evidence="7">
        <location>
            <begin position="200"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="8">
        <location>
            <begin position="611"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15815.t3"/>
        </source>
    </evidence>
    <sequence length="1350" mass="151786" checksum="C08E4BE053CC3B41" modified="2023-02-22" version="1">MFGLSSIYVPPSDGRSRGVSVDLRRRNSIGSLDHRLSSPYAGGEGFVSKVHPLSSAGLGSRALIIASWALVRFPLGLAQLGEAAELELDEERTMNIWVDMAKLRKGGNGVLTKSNRIGTVRKHKFCEAITEKSYCKRICWRRNGAETTETAAPKRQRPKGIKEASIIFCRRFIAIADHRQHRRVPNAMQSSVSSNEMVYGGNSTVGSDESHVMSEKVQIIASSIYREFETMIQKHGQESIKELMAHVVNVLESLDVAYLEKEELVVDLEMLKEENEQLLNQYERERQMRKNQDQKCLEMEESLLEQNRELESKVESMASIVRMLELRAKNANDHAMRLEEREADQKIEYEKLHERYNELLRTHIEHVERTKFLMGAEMFDMAQSLPIGTKNNRNMMAMSAIDTNVRGISDLISAHMSQSTHADLNLANHISNERDWHEEFGVEQTAAEILATPRAESEKEKSARIDAAAVEEERARPNTEPGEQSDVVEEGDGISLGADLTGQLVDPAEFASAVNDTFIGMGKEVENLIRENTELLETKNALNIVKNDLIAQVDQLSSEKEVFREDVRSLEMVKLKMSERIREFESELKELREKMNNSDAPVEETEDRSQGKRFTRVEMARMVMEKNQYKEKFLELQETVKFTELKRAKKHEEELAQRRSKSIWSFFSNLLGDGTSANESSGEGGRSQRNAHREGTRKSQLSSPTNSKKQRTYDIDMDLMNEKRKAERRQHYRTVSQYMKQEEFPNAYGWSMTSNKATESASIPVPVNCRPLLEQMPSLKVWCAAPSALHGGLRDGEYIVGDPISSCDPDLLLRTKEPQLSNDSEKRRRRKDSALLEASSLLWVCGSDEQRSFVSILDANQPSNILAGFSIEDANVLCVASAAGIRERDSRLSDEGMSVDSELCITGEYLSELQIPSEVAEDVDALGSVEFIALQKNEDQEIPTYSLPDEKLSPKRKLSLSQSFETNREAKRSLSSLANLPLHVRDALKSYEGCGTGNGNVLLTLPTMWIGLQNYFIHVHSAVSNWSKCLRRLKMPDAVLSILHLNGRLFAALANGSIAVFHRNTRGEWSDTGYFVVKLGSVTSSVCHLCAVEGNVWAACRNCVMVLDPVTLKIKHIITAHPRKDSQVRQMICCGRGVWLSIRLDSCIRLFHSENFQHLQDVDVEPFISKMLGANQLDSHLRITSLSELNRRIWVGTGSGIIVSIPLKEKSKTATVLAELVDRGRTPGQVIRVHSSDDNDSVTCATTPFCDITNAQLSFHGHKDAVRFLLPLLAEGFSDLTQSVETKKALMVSGGDGYIDFRLGDEDEANEENNGSNAMTEQIRARDLAHLLIWETECPVRQLTGLTKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCL7</accession>
    <name>A0A914HCL7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="11">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with lab-1; the interaction is direct. Interacts with knl-1; the interaction is direct.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914HCL7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15810.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15810.t1"/>
        <property type="gene ID" value="Gr19_v10_g15810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="13">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15810.t1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39870" checksum="62BCE93334B00B5B" modified="2023-02-22" version="1">MDMILTGHRYYPHRKAMTDADKINLDNIISRLLEVRGSKPGKNVQLTENEIKGLCMKSREIFLSQPVLLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRLMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPEVVSKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPSDKKSKFPYPGAGQNRPVTPPRATPAEPNKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDF2</accession>
    <name>A0A914HDF2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HDF2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16332.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16332.t1"/>
        <property type="gene ID" value="Gr19_v10_g16332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000011">
        <property type="entry name" value="3-ketoacyl-CoA thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF153">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="12">
        <location>
            <begin position="49"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="13">
        <location>
            <begin position="331"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16332.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="51399" checksum="E715C1641B485627" modified="2023-02-22" version="1">MKQVMSPGLKCFIGDSVSIVYKRAAGNKGSSLQQKAAGVGAQPNKRSNVVLLDAVRTPFLQSNTTFRELLAVDLQRHALKALVERTKISFDDIGHIVCGQVVQECKTSNIAREAAITAGFPDSIPCNTVTLACISSGVSVQNISQMIANGYLKAGIAGGVELLSDFPIRYNRKVRLSLIDLQKAKSFGDKFKHLKTVATNWFSPELPAVSEFTTGEVMGNSGDRLAAAFCVSRREQDEFAIRSHTLADKASREGKLEDVVPMFVPLGKHKGTTVAKDNGVRVSTMEQMAKLKAAFIKPHGSVTAANSSYLTDGASAALIASEEFAREKGYQPKVFIRETLFVAQDPKDQLLLGPAYVIPKLLDKVGLSIKDIDVFEIHEAFAGQVLANFKALDSDWFCQNHMKRKGKFGLLLLDKVNLWGGSLSLGHPFGATGVRLLAHAANRLKSEGGNFAVIAACAAGGHGMGMLVENYESKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDX0</accession>
    <name>A0A914HDX0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDX0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16609.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16609.t1"/>
        <property type="gene ID" value="Gr19_v10_g16609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019361">
        <property type="entry name" value="HPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386:SF1">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10228">
        <property type="entry name" value="HPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16609.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35602" checksum="6831A866DCDA0F08" modified="2023-02-22" version="1">MMTRKRQKLPNVQDGKKIVPKKAKGSEKENVEEFRLNSADDSLIQKLDSAFLVKHPPELLNFWSHAVKLNGERPLEAFAEMDSLKLGKKQRDYLLASRFPMDLPEMETILVHDGGHFCYWCDVPNELPSCLVHVNAQKEHFPAITIVGELNIFAAIQYLLLTTKPKQLAENSGRFAHLFPEKYDLSGYGPNYLQTLKKRRSKQSIGMPFHGLGIKVHVDKRGIGYRPVSENNSENARLKKNIEAMGTTDSEETKKALKEKFFKLFSWVQFANDEMDFGMGLEFGHDLFISNYACFDGVRHNSWEAFGKEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE39</accession>
    <name>A0A914HE39_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE39"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16295.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16295.t2"/>
        <property type="gene ID" value="Gr19_v10_g16295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16295.t2"/>
        </source>
    </evidence>
    <sequence length="406" mass="45733" checksum="357741DE1FD685CE" modified="2023-02-22" version="1">MDQACVEPSILIISRFCMSFRSVVQNSRLSANDNLTVAPSLDELIARKKRHERKNLKVLSSGWKSNTLNFLCLVAAFLLCFAHFEHLQADADYKLFELRNLSIKFHSDYLSAIVHYGHLISAIMFLLHVAAIKLSKTRFTFLGLLAVLSWPALFFVHYEQINQRDYLISRLALSAFTLLISTAILFLPKKPKRKKRPNTFCSAFSVCSWNTNLTHQRTKNRTEDFEDDVHSLSSKRYMKIGASEQHNGIRSRACLDKTKKERDAFDSMSLRSGKIVERSYAPSLGSFSAHSPAGPSKSFGWPLTIARKMNRTLLRTNTPFKTPGKMMLSERAISPGRKRRQGQQGPFTSLTYNPAVRKIASGFSERSSPFDDGLLGSKAAPASFSRDGSSYSSLSNSNTNSPFRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HET4</accession>
    <name>A0A914HET4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic peptidase DDI1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HET4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16335.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16335.t1"/>
        <property type="gene ID" value="Gr19_v10_g16335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartic peptidase DDI1-type" evidence="5">
        <location>
            <begin position="104"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16335.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28617" checksum="75FC35119CAE02D6" modified="2023-02-22" version="1">MRLTIIAGEHVSSLEISPDMKMENFLALCKIELPPIASVPIEKLAFTCSGRNFIANAGLATKRLQELNIRDEDAIQFELISASSTSYQTPYSYRLTPSSSTKSAHLLYIRMMIKNQPVIACVDIGAQYSIVSESCARRCDILKDVDRHHRMDAIGIGGSEKMVGRILACEVQVQGHIFAWPFEVMADRDIDVLFGLDLMLRHECVINLSKMVLRFGDGMETPFLSEQEVKREKQTIALEEVMQTAEGTKDETKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFY1</accession>
    <name>A0A914HFY1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C4H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFY1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16595.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16595.t1"/>
        <property type="gene ID" value="Gr19_v10_g16595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044069">
        <property type="entry name" value="ZF_C4H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018482">
        <property type="entry name" value="Znf-C4H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31058">
        <property type="entry name" value="ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31058:SF2">
        <property type="entry name" value="ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10146">
        <property type="entry name" value="zf-C4H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51896">
        <property type="entry name" value="ZF_C4H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C4H2-type" evidence="3">
        <location>
            <begin position="493"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16595.t1"/>
        </source>
    </evidence>
    <sequence length="544" mass="61054" checksum="475481747DA384E9" modified="2023-02-22" version="1">MTNERFIHHIRPPVPFLLPLPVIVHRPLNAQSSAAVADLFIFALHCAHAICAFISFNFAKIAAATCPPANLPTAGGWGHGGRKEETNQTDGAAGAKFNASNFANLLLSLRIHSTVWQTNTHWKGKSWRWSRFDQMGDPIVSKGSCSPTFPIRSVFSPPVVAEHVDDEQQHAPPGPSNMDETEDNGNLQKQQQQQQQQNGQQRSPEDVAEELIRIAEARDAVQRLKNERHTVMEELRELSGEGQLIERAERTVKELEEERRMHAEAIQQIIKEKEELEPVLSEVRQKRRRTETELGQRYAKVPLLWEQLSRRARDLEVPCVLTPEELLPKAFLSDGRELFIRSTTAEASTADDQNAASENAIPSSVNRAELSTPQPPPTNVLSPDQLQAVTALALMFQNPLSMHPHGHLFSPPPPALLPLPAHLRPPPRLYTPLLPHHHHHSHQHQLHPGTSSSATPVSMPTFPSRTLEEISRAREMVTNRKIPAAQLSIETQHQSPPMKVCTSCQELIHRNAPTCPSCKCRSRSKNPKKPRKKPELQQSELRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIX9</accession>
    <name>A0A914HIX9_GLORO</name>
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        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIX9"/>
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        <property type="protein sequence ID" value="Gr19_v10_g17595.t1"/>
        <property type="gene ID" value="Gr19_v10_g17595"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="C:cell junction"/>
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    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
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    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
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        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
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        <property type="term" value="P:receptor clustering"/>
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        <property type="term" value="P:receptor localization to synapse"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
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        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
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    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
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        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17595.t1"/>
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    </evidence>
    <sequence length="123" mass="13325" checksum="479D82E955946068" modified="2023-02-22" version="1">MNSMSFTMVQQKHINSPTSGGVRLISSRRLFTINRDPANGFGLNVVGGIDAPHIPGYNGIFISKVRRLDLDGINEGDQILSVNGIELANKTHAEVLKILREASNNSTFMIEVECGAKNSIATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ28</accession>
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        <submittedName>
            <fullName evidence="10">Titin</fullName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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            <taxon>Tylenchomorpha</taxon>
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            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="palladin isoform X1"/>
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        <property type="match status" value="21"/>
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        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
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        <property type="entry name" value="FN3_dom"/>
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        <property type="entry name" value="FN3_sf"/>
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        <property type="entry name" value="HV_Gp350_C-term"/>
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        <property type="entry name" value="Kelch_1"/>
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    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF26">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="80"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="866"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="878"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17150.t1"/>
        </source>
    </evidence>
    <sequence length="947" mass="103711" checksum="CAFE4A6B074D546D" modified="2023-02-22" version="1">MSGQQGEDSLSNESSDQTFGLPLKTDNVRCRGTTGHYTDEWAEQEEMLAQADQMLLLKDDTHKDTLLSRLNTFRRNRAFCDVVLFVDGRELLAHRAVLAAISPPLFDLFLDSGGPSDEDDHTLLPAQALELAKAASQVATTSANRGQQPQLTSSQNGATSSTSSVVGDGGTAQMAFFEFPQADFESMEALVEFAYTARLRIASRRVKELYRTAFALQVFPVAQACAHWLAEHLTVSNCIGIRRQANLNEDLFLLKRSDTFIRDNVEAVVNESDGVRDFGAAESDGAHHKAPFLPSGDELAFRCLCFFQHKSRRAAGERIDTYIDSLTEKTHLLVAYADEHQQSNNNATTITSTSVNGGNSGRLQDANELEEKSLLGSCDLVKDYRRSKSIAANGKKTLTNSKPEQQPIIHVTGATPIKLNSACAGRLLSTQKEDIKFASRESLCSLSSCCSVGSVPSEGIAGSESLAGGNLAGSRQIICVQPTAPGFWRGADPRQSHQLGGKQYGWLCAFAGTWRGALCHWSRFFECSEELNIGDGVVQWRPLAPMCRERARFDASVVDGKVFAVAGSNGTNDLSSCEYFDPTTGHWTEVHPLERARSHNGCASLDGLLYCIGGSTDHKILTDCVRYDPKTDEWTDIAPLKAHRSQAGCTAWRGLVVCVGGCDLWNCLDSVEAYDPHTNQWRSLARLRTPRRGCAVAVLGNSLVEVLDSPNTHWRPGPSMQQSARVHHHAVSAPGIGIFVIGGFDGTQFLASMEVLESEDSGWRAWLEKREHTIWVFGNCIRILLLRKPLIKALNIMIRPICGQLMRKGAVHYSPTFKLVNTQMMTSSGASTSRYFAASMVPLLPVAYFVHGPFMDYALTAAIVLHSHWGIMVVIKDYARPLVIGETLANMAPVAGYIASVFLLFGLLMFNYNDCGLTKAFEMVFRCDGAGNDPTHPVSDDQQTKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJZ7</accession>
    <name>A0A914HJZ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJZ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2179.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2179.t2"/>
        <property type="gene ID" value="Gr19_v10_g2179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin-binding" evidence="2">
        <location>
            <begin position="624"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2179.t2"/>
        </source>
    </evidence>
    <sequence length="744" mass="84021" checksum="741B580451C8C54F" modified="2023-02-22" version="1">MTSKNSKPAIVDELNEPLLKMDKFKVPYIKLSNGIELPSLTVVPLLNLDPEQKSQVFRAAISAGYSHIDLSNVRMGTPSLISAIMDDLGHLHTDCENLFLTAKLVAEDDLDGMKQKFADLLNCLHTDHINLLMIGFSECGRRDRQDKKGIINNNTMPTNILEDQLEQGQQGRTAAAKHIDTLMKAWHVAEQLYMEGKVKALGVSRTDIKLVKQLCERAQIRPHCWQIDLAPLMANFDDVLELSKHQKLTPIIRANAMGASSKFGSQQQRGFYHTLLREMANKYAKSATQVLCRWLYQRDMAVVCSCATANRIGDQTNIFDFRISPEDMRRLNGLYNRNSIPSPYQLPQKASTSERSRHLIYACRHSAELALTFALLGITFMILAMEFGFAKWSKLDELARCAVAATTAALLGFTVRYHVLHTKYHMHVNAIGCWRSALHVRQRLQVLLELIVCALTPVPLLRFPSGGEAFACALMFLRLYWLPRVLHLRSRLCTDAAAKSIAGLNRVKTDTRFMLKLMLFLHPGPTLSTFVFCFWLVGAYILRLCESNIEDNKLLTYYNTLWMMCVTFLTIGYGDIYPVTTCGRLMAIVTGIVGVCVASMIVAVIVQKISLSQAEERVHKFMAKTKFAKSLKVTAAQVLKESWFVYKNRQNLDKLKYHQRRQSAAICALRKLRKEQRVFQEDDCASIDDVAKTILNAIELIRAQGCAQLSANDRLNTLEQKLNGIQEGINALPELLAKTFIDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK54</accession>
    <name>A0A914HK54_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK54"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1868.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1868.t1"/>
        <property type="gene ID" value="Gr19_v10_g1868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1868.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42039" checksum="C9C349248E851CD8" modified="2023-02-22" version="1">MELPFFNPDEYERLYNCSAYEIDQVPLSKRQNIPLGVAFLTIGIICEVLYVPCMIAIRKHMDSTCFKFMFYIAIADMLCLLLCGIVTGYLAIIGAVFCTAPTFIYISGAFPLALWVTETTAEMFLAFNRCVELSSSRLADLLFGGKRIYLWMVVTTLYGMYFVLFTKPLIFNGIYITWFQNPHVGYIDSFEDTYRNSMQSIHNVIVVAVLPSIYLLFALILFIKGRKISAAAGPNASLVNQKSIFIQVVLISCVNAIASAIYVSMNLVPLSKLLILVGQFCWIMAHGIPPIIYLLLNKTVRHDVLVMFVRPIGLIFPFITLPLGGKTSIIRTLETNRVTATTNSKSIRIIVSQANRAKSLATIEPCATKWFQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKK4</accession>
    <name>A0A914HKK4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKK4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2181.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2181.t2"/>
        <property type="gene ID" value="Gr19_v10_g2181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2181.t2"/>
        </source>
    </evidence>
    <sequence length="226" mass="25360" checksum="99442652801FCB58" modified="2023-02-22" version="1">MIGAIIAICCQTKGPQQRLAPTTVAGNARDANASAEDERNLNLNKWPGTRTATKRQNTDQIILAPLTEKEFAKNENQHYLNIKETASRKPKTTDEINVETIGGIVIIHSKPKAENLDNKNIFGTILKCHPMHPQYDQTHEESPKIEQYASSELTVTHELEGVRYSSLSEIESTVSTTIFRNNNSEEPKHNEDEKNLQKSTEFTSSILLDALEATMEKQHSNFSTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN77</accession>
    <name>A0A914HN77_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HN77"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2157.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2157.t1"/>
        <property type="gene ID" value="Gr19_v10_g2157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF84">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="778"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="889"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="82"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="336"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="955"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2157.t1"/>
        </source>
    </evidence>
    <sequence length="1087" mass="126884" checksum="1324939AD91A14AB" modified="2023-02-22" version="1">MSNPKRVRLERLHALDFDETEDILETRSLDEGAVTFAELNKMNPKIQPMKMNKERFELEQNGETSHGTARVKPAKFHIPSSYFSDGKRLIDFVLVYEEKELNNSEDKEDSNEDVEDANSHSSPQRSPHLHSQKRRMYEESLLGLGLELEYANATAINPNIKFVLIHAPFKVLMRQAELMMVRMPVHRNDVRKEWNFTDGFVNACLKRLKFLDFDPRVKKRIEPETYFCQPFVAQHFECFVGYESPETFFSRADRARMVHDLLIRARYDRGESINKLRFGIDKLLRNRTYTAAFPLHDELNKKAKRVDFEKCSDRQLLYESWVKMKNVFKYQPLDLIQNYFGTKIGFYFAWLGYYTRCLWPISLLGILFMLYGVITVSRDAPSNDICEGNIGHELICPICDSCDFVPVNATCLYTRITYVIDNWSTIIFAAIMSIWITLFLEGWKRYHAELAYKWNVQGFEPEEEMMRPEFQFRRKKMSKLNPVTKQEEPYIPFMEKACRLCGSAVTVLFFIFLVLALLFGIIAYRVIVLRVFYASTFLQNHHRTLAIWVTSGTAAMINLIFILIMNFFYSKLALKLTNWECPRTQTEFDNSYTFKVFLFQFVNFYSSLFYIAFIKGRFAGMTHLNRWIDADRLSFGPFQPFEQCEAAGCMVELVIQLAIGYPLLSYWVRRWRFKIPETKKQKAERISKERRQTIKCFSPSTKVSLYEQDYSLNVVYQQFLFDEYLEMVIQLGFVTLFVAAFPLAPLFALINNILEIRLDAYKFIITTQRPVAEQARNIGIWITIINMISNIAVLCNAFVIAFTSDFIPKLYYQLTQETLHGYAEDTFAYFDSSKFIVQNSEFPNTTYCRYQDYRRPPCSLINQPISRQVWGQSFETICDDNYELQDKWWIILAFRLVFVLVFELVVLSIKAIFAYLIPDMPTKIVIQLQRERFLMRQAILQRKDTPEELEAAELEEREQTQLTTDRPNLGGSWQHSGDIDSMAYQADICETEKSSKQKRSSNSGFGGLFSRRDMPSLSPRTSFVHELPLSTATAAEAGDNEKASSSYPVMQKRPSHLWPTPSLLLLTPPSRPPSQSTKTIEVLQQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNP3</accession>
    <name>A0A914HNP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3205.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3205.t1"/>
        <property type="gene ID" value="Gr19_v10_g3205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3205.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10725" checksum="FB29085A7128B8AA" modified="2023-02-22" version="1">MKAELTRAGFKNSYKQEIDKTVTKELGLNFTTIYAWKRELGQTMTNYSDNEKFEIVKKLMRMKSGHSEQFPIGNVNLAKPNHNINTPITNNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPJ8</accession>
    <name>A0A914HPJ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPJ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3467.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3467.t1"/>
        <property type="gene ID" value="Gr19_v10_g3467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3467.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21503" checksum="FF569482CBD5A54D" modified="2023-02-22" version="1">MGCTTGRCCTTRLCNISPTQHFAYVTFRLQSQKATFRLQEVLRWEIEVVRQPLYPIRFWNVHRQAASAVARTNNALESSHLHFTRDLNNHPALSDFLRAVSDDADKQHDIYRSARLHRNSQHRNKHFVLQEQAIMATLQDAEYGTDIDLLQVVTLLGLQIKGYLVGLHAQRRESEFDEGSTIEQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPL5</accession>
    <name>A0A914HPL5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HPL5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3478.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3478.t2"/>
        <property type="gene ID" value="Gr19_v10_g3478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="425"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="736"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3478.t2"/>
        </source>
    </evidence>
    <sequence length="896" mass="101741" checksum="CCF875FF2680CEF4" modified="2023-02-22" version="1">MQLHRCSDTWCGPKDSKTGRCKKGFPATYSKCTILHPDRPAVYFRPSPAEGGAQIEVNKLIYDNSHVVPFNPFILLRFRVHHNVLFAYGNKANIKYALKYPFKGPGHCYVECKEESGNKIGIDEPAQYAKMNFRGATEAYAVVNSIAFVRLSHQVVKLSIHLPNQQPIVFRAGQLVSKAQQIEQGELPETPCSAYWKQWQNEWKDDPEFKDMLFVQVPERFRWVKDKWVAYKIKLTKRPPIGRIVPVPPSDPERFALYQLMRHYPGDPDHLKMVNQQPCSSFIEAAIKHGLLEDDRVWNKTLEEASLSRWPDQMRWLFVSILVFGQPSNARELWDKYKQHMYHPQGIATMAQRQAKELQALADIDWRLFNFGFSCIHFGLPDPPNSIAKNTGKAIEEFFFGDDDLNVPPGLPNANKAEQNQPPPLNSDQQMVFDAVVKAIQTDPSDESVPRRLFVYGDGGTGKTYLFGQIIRRLRKAPYSHKVLATASTGCAAILLPYGKTAHSTFRLGREVSLDKLPSIPLESFFARRIREAQLIIIDEITMLNNTVIEVIDRVCKEMAIRQQKEILFGGKTVIFSGDFKQSLPVVPHEGLAAQVAACFQTSTLFGQFTTMKLTINHRLGQGQQDYMKMCRQIGHGETGEFFWIPPQFLVQSCEELIDFVYPDFQKLLGNDKELLNRLILAPHIQTCDEINELMMDNVPGQVREYFSTDKPLDERPLDIDEIESEVAALNQRTDSGMPPHRLRLKVGCVVVLLINKSDREGLINGTRIVIEELGEDKITGRAINGTAVGGQVRFFIERTRNVYEDKAPGGLKYERLQFPIKPAFAMTILKGQGQTIRTVGIDLEREVFSHGQLYTAFSRASDGNNVRVYAPNRETDAQGRARVLNIVATNMLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ10</accession>
    <name>A0A914HQ10_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ10"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3581.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3581.t1"/>
        <property type="gene ID" value="Gr19_v10_g3581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765860" evidence="2">
        <location>
            <begin position="25"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3581.t1"/>
        </source>
    </evidence>
    <sequence length="890" mass="97083" checksum="861F68773C81F173" modified="2023-02-22" version="1">MSGKCMFFVMGGITFLSLCLNVLAKDYVKNAFAPNSKDFIADVWTGAGLGASLGSAGGPEVIIAGAAAGVVVAVLKNTLGYAICEGKLGGCSCRSGTCVQKAEERGLDLCCGDSFEWKCYCEWNEELEAKKAAKQMRQDTALTAMHISDIRNCNPEKTCGHCGARFECIEDAYWRWATGCCPTGTKMTCCVTTTTTTTTSTTTTTTTTTMATTTTTDENLFCKKAFFEQHPEKDKYEEQEDKKCAQNERHCYVLNCTTVTSTPSFDQFIGYKVEWGCSVTKESFKENFNQGLGRMGSGRFPGSKCNDAVGPKNYDMANVLLDAPLFNPTHSSLWCKGGHFWKGYHGKNISICNAHEHYCYVLNCTLALVGESGSTESEHYFFTQWGCTDKKPSKLLLDNPGQLIGESEANRITFQKCTPNVGKVNVSMSNKGIEVPTPAKICKKASKWLSYNESSDKSCSPSQRYCYVLNCSTAFEGDNKPEIMTEWGCTDKWYRTDDFLQGKGRQLAETQIGPIPNNYACNSAVTLNSNEATMLPIFITANTSNSTLKCKQRHETPDGINDHGGRCSPDTIGCYAIHFIHFNMKTIAALILFFICVQLDFCCGLECKIGGATILKNKLYSDDTNIGTCPADSNYCLAITCTKVGALRAFSQIVWLCVHTLDVSGCVENTKKNFADNRNMTGIECKCDHGKKGENLTNVQYELPTVKPLQCKKGQFDSEGFGGTLVGECKDKDHFCFMASCAKGNEHVKQEWDCSGDRNCSAISERIGKAVNSPVSCKCLFGKADLDMANENFTREMMSTTTTAKPTTTPKKQTTTTTTAKTLAPATTTTAKTLATMGKSSRPSEGSTANTPEANHSARHSVATFCKMLMAIGILASSHSMLIGLRFNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQA0</accession>
    <name>A0A914HQA0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQA0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2704.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2704.t1"/>
        <property type="gene ID" value="Gr19_v10_g2704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038058457" evidence="2">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2704.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33615" checksum="50FC90E8ADCBCAE4" modified="2023-02-22" version="1">MIEFWLLILVLFFATNSLDKAEAVKVKLEGTQLKTFDEIFGEGWWDKDKAEEWHKLTLEENFHHQIDRPNTQLGPIEPNSTDQNPPLKESDHTGQIEPNSTDQNPQLKESDHTGQIEPNSTDQNPPLTESDHLPILTFDELFVEEWWDKNEAEDLKMPAPTNFGQNVHRQIDRQNTQIGQIEPNSTDQNPQLKESDHTGQIEPNSTDQNAPLTESDKPPQHEYANIKQKELMKRYYEIKDKKYKINDADIAKMLKIGTRTLYKWKKQFNRQQLDPTSVDGHSVEEIIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQH9</accession>
    <name>A0A914HQH9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQH9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2775.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2775.t1"/>
        <property type="gene ID" value="Gr19_v10_g2775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000860">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF14">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2775.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="48828" checksum="99367F8D1B7406A4" modified="2023-02-22" version="1">MALWRDIGLTYTRYSQVAASALRECLKGGGTADTRKAAEMKTAWCTDGSATDNVQFQCDDSSKSKRRSQITVLLLPVAVVCHIRLFVRHSQVSMAYCCAGKWLGQAATGRQGRKSGAGTVPQAVHWRTVTEHHRRIAARLLRSTKRSRGFGFVSFQSADEVDAAMTARPHTIDGKVVDPKRAVPREQSAKAESNVSTKRLYVSGVRDEHDEETFLRYFTDFGPVAKVEIIQDKNTNKARGFAFVTFDDYDPVDKCVLLKSHMIGGYRCDVKKALSREEMQKAQQHDRDRMERGMRSRGGPPQHGRGGDYGPPPPGYGQYGGGYGAPQPAWGPPPPQWGGYGGGYGGYVQGPPAAASWGGGAQAAVGGPLPAAGAAAAEQGQWGAAAQGWGQQGGAAWGQQAGAGSWGGGSAPGGGPVASGSYGDKPQQDTHAGGAWGQSSAAVPGGVPPPQQQQPWGAGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQT6</accession>
    <name>A0A914HQT6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQT6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3795.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3795.t1"/>
        <property type="gene ID" value="Gr19_v10_g3795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3795.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15094" checksum="85AFB7CC945D4C04" modified="2023-02-22" version="1">MDTKREGSAWHRYALIEDDKALLAEMPAQVIVSGDKLTLLRDSPAEADIAPVGQLRRDTENGGVVPAAFEQQHCASSVLAQQRCIATTTHLVAVMDDLFSWTITSCTRRFATRHHPLLITTIPKTPMTAARTRRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRN7</accession>
    <name>A0A914HRN7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRN7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3832.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3832.t1"/>
        <property type="gene ID" value="Gr19_v10_g3832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3832.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14334" checksum="7453FB633F6AF9D1" modified="2023-02-22" version="1">MKSYGTSKVWGPNVGAQTSRSRLNAHKKRYKSGFGQELKSAKMYYYSPLPQLFDLINHLDPLPLRAMHSDNVHRMSRIIIGSLHLEWPILLHFCCAIFRKISIFKGYIAVFNRLKNEQPTGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRU3</accession>
    <name>A0A914HRU3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRU3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3369.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3369.t1"/>
        <property type="gene ID" value="Gr19_v10_g3369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3369.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12324" checksum="5149201EE251AE36" modified="2023-02-22" version="1">MSAKITPSALFGTSERVSNERAIDRTPDAGRNHGVPVRYRHEMMYYIKFPDGTTSRFYVSRVQELQPDTNDENIEFLLDRFGLVHAQQERVETDRPQILVSDLNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSC4</accession>
    <name>A0A914HSC4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSC4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4022.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4022.t1"/>
        <property type="gene ID" value="Gr19_v10_g4022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="301"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="303"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4022.t1"/>
        </source>
    </evidence>
    <sequence length="689" mass="72559" checksum="1E90E5E9CDE82F29" modified="2023-02-22" version="1">MNERLFVEQSNSPNLIPFSRSQKLLCSQSVEPLSSANMNMAAVQLLLAQQQLQQQQDPQQLQQMLLHMQHVFPGFHPPSAPAPSGGGPSGTSPTPPNGTFSCLDPLPGLSPIELMAKPPLFALFPPHTALLGPVPSGIFSPNSLCGQISARQQQQQQQQQQQQMGNVDGGTTTALSKREDHGIGGEGGGGANSPDGNATVRRVVERDRGQTTALLGDGGMFKLETMPTPTGGVEDQVHFRRLSTASSSGLSPDHPSKSALSPPIGDYGNGQSSPLNGTAGIGDGGGEDSGGGGEEESCKRSKQRRYRTTFSASQLEELEKVFMSTHYPDCFQREELAEKVHLTEARVQVWFQNRRAKHRKQERSIQHHVHPLAHSSAMALSAGPVPPFPYSAAAAAFFSGIFNNPTIGGLISSSSADAHHCTNSAMLAMANLTAAAVSTQQGMTTTAQFVSGGGDNSVASPPSSSLPSQLNLRTISTPNSTNEDHQPFPANCLPHHSTGSASPSSTNGRTVATVHMDSGGMAREVHTQQQKHFNFSDIASLAECNQSSSSSCDSRPGRQPSSSPPGRDGGIPGRDAGRDGGIPGRDGGILPPAASLAPPAVSAASSSSLAVPCAFLGSSPFDASAALFHQYLLQQLVAFQQPLIKRRDEVKGEGEGEGDGRGSRKRKMDKDGEKEREEGKEAKKSNNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSH4</accession>
    <name>A0A914HSH4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g381.t6">
        <property type="protein sequence ID" value="Gr19_v10_g381.t6"/>
        <property type="gene ID" value="Gr19_v10_g381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="415"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="834"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1356"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1411"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1487"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1606"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1755"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1986"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2100"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2306"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2497"/>
            <end position="2551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2208"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2412"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
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        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
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        <location>
            <begin position="653"/>
            <end position="664"/>
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        <location>
            <begin position="681"/>
            <end position="696"/>
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        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
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        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
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        <location>
            <begin position="883"/>
            <end position="912"/>
        </location>
    </feature>
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        <location>
            <begin position="933"/>
            <end position="970"/>
        </location>
    </feature>
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        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
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        <location>
            <begin position="1040"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1071"/>
        </location>
    </feature>
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        <location>
            <begin position="1074"/>
            <end position="1089"/>
        </location>
    </feature>
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        <location>
            <begin position="1099"/>
            <end position="1114"/>
        </location>
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        <location>
            <begin position="1138"/>
            <end position="1162"/>
        </location>
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        <location>
            <begin position="1163"/>
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        <location>
            <begin position="1254"/>
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            <begin position="1357"/>
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        <location>
            <begin position="1411"/>
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            <begin position="1511"/>
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        <location>
            <begin position="1524"/>
            <end position="1533"/>
        </location>
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        <location>
            <begin position="1626"/>
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        </location>
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        <location>
            <begin position="1755"/>
            <end position="1770"/>
        </location>
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        <location>
            <begin position="1986"/>
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        </location>
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        <location>
            <begin position="2021"/>
            <end position="2034"/>
        </location>
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        <location>
            <begin position="2036"/>
            <end position="2048"/>
        </location>
    </feature>
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        <location>
            <begin position="2049"/>
            <end position="2060"/>
        </location>
    </feature>
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        <location>
            <begin position="2065"/>
            <end position="2084"/>
        </location>
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        <location>
            <begin position="2326"/>
            <end position="2338"/>
        </location>
    </feature>
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            <begin position="2340"/>
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        <location>
            <begin position="2350"/>
            <end position="2359"/>
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    </feature>
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            <begin position="2367"/>
            <end position="2386"/>
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            <begin position="2497"/>
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        <location>
            <begin position="2532"/>
            <end position="2551"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g381.t6"/>
        </source>
    </evidence>
    <sequence length="3082" mass="337820" checksum="B7C0FCA0FDF7A788" modified="2023-02-22" version="1">MYTEILELVNFFARFFHLRIPRLKIGMFCEHFANNCFLRFHLYWNLNQPKQYEELRIIRVSHQYTDELFTSAASAVGLQLDELLSCIPERLIIVYVNPGEVFYCPGDYSPPVAVWVGPVCEDLKYNETCHVTFPPPPIPSSILPTHAIQPLIPRPTSNLPGAGCVNVTVDFSVLSWRIPLGLVHPRELGYATNPTSDFLMFRYCVPGTPNYTVETFASTRFGSYRKRPDYEFFTRLQHSLLLLNAQSSSDDIGRTFPLATFYRLVFFPLSPWALCPSLGFFPFGAREFLLLNISDRLIFDAKWVSSELGSKRRYNGLLEAEHHSEGSCQGFSMARRCDTTDRHLPQMSHLIFFLRPIYQLEHFRNVLAVLLGNKSKRTICNSEFKAAKAGMKEEALTGRRQHRDVQKHKFPGSNSELIPVYTKWANDLLQAADLPPLTDLSGELCMPLKLIVLIHSITFEFQKVPKEQLIALLSHNDALISIKQSLAYLCQIGVPLIDSIQAKDIRNGHLGAILQLLYQLSLYHCACQQQLHRQRPEEAPQQKQWPNRSIRPSSAGRTCYTTASSSTITPTNTRTNNNLPAEEKNQWENRTVETSASRKVAFKMPPDASLTSLEGANREGTERKGEEQEMASNVRLSRIASTHRSALRPPQISAAVSSKRSVARPQPIELLEAPKALGTNSSRLVPPSSQRSSSQSANTSPKGLLRGGGTDIIKWPINGAIIRPKIDFVPPALPASKQLPPAAGFQTTNRICLPIPTVLTPEKKHSLCPEVTNRNSGRNSNGGLSDESKRTAPEGPNFVEASIVCNSSSQHDSSVSPTVHQQLQFQKSVLRQPTPSALAGRSKSALRVPISSIRSVNPTSDELNEHSPKQTGQSLPQHHHHSSSSSTSVPVLVSSSSSLPTSASSSLRTSQLRPPIVSKPVPPKRHTSTVIRSSEERLKEEPREGEATEMNRLRLFGGKDRERERKREKVSAPICIGPPSTEQHEAHQMPSYPPRGKDLPDQNGEINKLRKPTSTSKSLLMPPSSTVSRRVTATAGGGVQPTSGRAASQQLRSGETAKRGAGGRAGGGGGTTASQQMNTSQCSTSSNGGRKSGQLKKYSQTPPSLMTTSSSSSSVGIRITSKPASSNSKLTGIPSAKKTKEELSGNKTDSMTKEEETMRTEQQKCQAANSPPTTEKKPILAVKGISVPSGGTPSPAQKRPSLCGGRPSSADSASECPRSPLMSDSRRNPHMVVGVVSPMMHQQEEVLGGTSEANRSEERSVVDQQREKDNPSECEPSAIQKPPEEPIVVNSEMEKWNFPEQMLGLSDGSPPIHPEKVAKISKLAKAVPAKRLIIPTMASQILPEGTMEEQNIGGRKVPSEKCRGEECPSPSVPPSMAPTKLMSVLREEQASPCPSSSLSTPAEEETNRCYHFDKDHPNHRCQDGHSSQQHQKVSPDELISAAVATASDNSTDSVRTTIQIHCFSTKNDQLGELLGDCAIIGGGTAPATAEDNDGQQNLHKNGKGGIMGQKMDGEEGEGRRKMIDSNNGKQQLATEGAGKDAVGVISGGATSRNQHHYPDNPPMSGTADYASESELDFRRQPMARHLYSTSIPAGNKLVMALDLRPNSGTALRGGGRKSRFRESYEDSSSLSSGLSEPFDDDISTDDLTGSSSDYLLGQLSPNKMRQFAHENGQKHIDFVSFQKPNGPQPNSMVSAAERERQTAGQLLQKCKSAQRGCAYFGSAGGGGPIVDPHRPSTSNGYLPTPAVGHFVHNSAEGRRSGCDQHHRIEQSQHPQKPYQHHPNEQLFALREQGQQHRRQQQQQPEQQNQQQFDLFRPYHTITAVDWPPLQYQQQQQLSRTHRPVDARRLLSPPHNLMVLSDDGDTLSVAAGDVGERTTRGQSARPPGATLLGTQQQTMAATHLQNADLLHRRQHHQQHPAYHTHSLDRHAHLRVLSAGVRPLPAAADDHSPRQGQFANISRNLPHQRLQLNSLLISPRHHYSVNGYTSSTFAPPGNTNATSSSVHRRSRGGDLYGYSNGPLLPPQCFPPPPPPGSSARSSVASGTPHQRSASLSAMSRSMVTVLEQHEERQRRRGRGDGGETQRRVLEYVRGQLEALNSNARGDVIEAPPADKSAKSSHPPLPIPPQQRSSPHLNRRTPLSLPRQLELNNNHLHSAGSLSARGTDGRIYSNLKFPNSGVNSPTRLPIQQPGSQLSLASSIGSTYSTIEERYEWEIGKLQNELESYRTHVQLLSQKNSGFNCVIQMFDNRLQSIMLALGKLQQKQNVKRDEVERLCNEIEQLRALSVTAGVVPFSNMEGAACTLKSAGAKGDEQQQNGGGSNKKSWKTNVDTQIRSSFNRAFHKGTKKSKQQQQQLQPLKDTTDNTHSSFPSSFLNLANNNNSSSSSMTSKMDSTKRELETRELALTDVQLDALDKAKEIDILRETVNRLQHENKLLKYNFSLLERRVHSESRASSHLSLNTTCMAGPGLDFDAATLEEVLVEAPEQLAALYDLAASSPSSGDISVNTTTTGSSANGAQQFVPAELANKSTDRSSFASSTTSSKRSSRGPSTALPSAKVVLCVDLSGRLDSPHPLGHLMSLPPSNSLCSISRANSGSSSTLSSQASSSLGSVMSGAAMTSKTGGTARRELTVGYLPLPVGSATSWKDLDQKLGLLLEEYLHRIDPDLSLGIDSYSSIIGYQIHPTQQQSDTGGHSEIFLIRRRGSVSETGQQQQLVENCAELGELLPKLSPAEALQPGTLIRIRLKGVVQHSVDALVLESLFPRHLLEQLLYQLEQHRRLLLFGPTGIGKSNLARLLAKYLLMRLERNNNNNPNTSKALVDIRFPMDGEKHRQEGNQQQKVKEQLIAALRPASNTAVLVMDNLQWKRLGTVLEAFNNSAAGEELLAGASVAADLPLSSPFVICTLNRTCVDHSPVQQLQLHHNFRLFALSYKMDAVNGYLGRYLRRRLAEQELSSYASLGPPALCPSPADPLESVLHFLGRSLRAVNEFIERAATGGPDLTLGPRVLLQCPLSSEEAQGWFVQLWNDKLVPYMRKVLTESKAFPIPAVDGDDKVSAFAKDPTDEIGTLWPWTGGKEQLLKICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSX3</accession>
    <name>A0A914HSX3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSX3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3914.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3914.t1"/>
        <property type="gene ID" value="Gr19_v10_g3914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3914.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18961" checksum="8A938480051183AB" modified="2023-02-22" version="1">MQEQAKKPLSTYNVRRIIDAVKIEYLDNVARFRVIFNERSISHLSFSPQLGYVLGFQDPQNVRGSEIAKYGCDLKGGFSSFAVYSKGLTENMIIGNSLSSLLRVVSVSGAIPGEYNEKIYDSPIFARVLPREINEIEIELRTMDKGRLVPFAYGTTLIVLIFKKVINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTI6</accession>
    <name>A0A914HTI6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTI6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4324.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4324.t2"/>
        <property type="gene ID" value="Gr19_v10_g4324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4324.t2"/>
        </source>
    </evidence>
    <sequence length="220" mass="25061" checksum="0731743DEFB79966" modified="2023-02-22" version="1">MESIETQCSSNIGGDQAKDNPYKLGGKIPGVCTEDVLLVNDEAVYVNKQVLAACSKFFRALFFGENAEEVPKVKIDGPDPVEQFERLVIATHDPWRLELNDECVEEVLLLANQFQFESIVNHCFEFLMDKSKKLATCKFRLADECGNVIMKKKFLNAITKDDFAWQNYFKNRAEEHWKKAGKMSKVQFAEVNSSIGNFSQKFLDTFDLLFKVSCCVILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTQ8</accession>
    <name>A0A914HTQ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTQ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4590.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4590.t1"/>
        <property type="gene ID" value="Gr19_v10_g4590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF73">
        <property type="entry name" value="LD06050P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="3">
        <location>
            <begin position="157"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4590.t1"/>
        </source>
    </evidence>
    <sequence length="758" mass="84516" checksum="CCECF1C4C0B2B9DC" modified="2023-02-22" version="1">MELSEAIERCRVDDVFLCEGPRPPQKGSLGLIGHHLIFSPAPLSPCLAAMDGGEDSPSAAAADAGGCGTDQHEFWLLHRAIDRVIVEPISRDPNLRQQGAFLRLKCKNFMHLCFELNALADCQAVARSIEKLSNLHGVAHDYPFYYRCPFTVLDNGWEAYSVEQQLFAKLQMHTKDKWRISAVNRGFEVCASYPELVVVPKGIGDDYLRISATFRDGGRFPVLSYYHRPTRSCIVRCGQPLIGPTNRRCKEDEVILNAFLSKFSKGMIFDTRTKLVAQTSRGKGGGCESQMYYSQWKYVYGNVSRISTLRESLARLIDACVENHADKWLSRLANTGWLQYVVDALTAAATVAQVVHCMDEGSGGEVPVLVHGGEGTDSTLLVSALAQLLLDPDARTIRGFQSLIEHEWLMAGHPFSLRCAHSAFATGTLTGPNESPVFLCFLDCVWQVMRQYPTSLEFNERFLIFLFEHAYASEFGSFLGNNEQEKRRLGVKERTVSLWSYVNHPAALPDFISTLYEPYAQPLWPSVAPQSILLWERMYFRWQRIWTDVDRCQQVVDECKREEKELRARCLMMAQQQQRKQQQCHHQQQHPPQQGENSMSISVCSTITSCSLPSSMAPTSSATVPSTSETVEFHHPLDDDQPQHIKPPPFALDEVVKLDRLNIRALSKEDDDGDDERTDFDTLSMNHRPGGAIGWTTKQWRLKQQNGAGGGDDRNNNSGATITTAGGVVGSGASAVLDGAKQWLQQRLGGGGGGTSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTS2</accession>
    <name>A0A914HTS2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTS2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4139.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4139.t1"/>
        <property type="gene ID" value="Gr19_v10_g4139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF116">
        <property type="entry name" value="ABNORMAL CELL LINEAGE PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4139.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39291" checksum="79CC4A670142E926" modified="2023-02-22" version="1">MLLLIFMTTNSNCEPHFGQIQLKEMLQSRQHKTFRKPEKLLRSCPRELLQLKSFRQFPLLCRVQPALAIVAYEGIMDAMDECRQQMRFEPWDCSQPATVLHEPTIIRNAYRESAYLWAMSAAGLAWGVATACAQGWLDECKCVGEDGGQSIVPFRPTTDWEWSGCSYGVHYGVITARKMLTRNVVGGKSTRTVLSRRHLLRKLEKHNLKVGRMAVKRTLTSSCKCHGVSGSCQQKTCWKKAADLPAIAQHLAQKYKSAKFVVSARPDEEIRAKNTELVFLERSVDLCSQFHYDVHQKRSLPRICSWRNATHSEGDCSDLCCGLGYSVSHECRECLEHRWISTCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU00</accession>
    <name>A0A914HU00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HU00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g375.t1">
        <property type="protein sequence ID" value="Gr19_v10_g375.t1"/>
        <property type="gene ID" value="Gr19_v10_g375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF152">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="110"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="278"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="906"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g375.t1"/>
        </source>
    </evidence>
    <sequence length="934" mass="105476" checksum="BF169F9675BE63FB" modified="2023-02-22" version="1">MKVFSFLFSHFRLFYKKRLRYALPFLILVLYTGFGAYIFRYFELEADEQRRAHYRANAEYAFKRTLSRMLEVRCEEGLDESGQSLQARHVKEHLFWLIDYLNLTQVIEERTESSPWTWVGAMFYAGQLYTTIGYGIPITQTSGGRLASIAYIMVGIPLFLLILTEIGRLLARGLRKLYKKLHAARKKLPEASRKMSEPMRAIYHITAAMAGTAVGSAATPLINGAARGELLREEEAKQREAERRNAQKALEKLKKDSLRQEKGEEKPRQFPIPWALTILIVWTLLSAALFCVWETEWGYMTSIYFFFVSISTVGLGDLVPTNPDMMIVNFFMILIGLALLSMCIDLIQKALQKLIERLIEQYIDEIEKMASEVVNVQDEEEAPEDIPPFLPETAAVLTEGESRRGSNARRKSSTIGRVKDWLAERASNILVNKIYPEESSESESETEDQKLKSTEVAEDFLELEAVVVEREPLLNPETAINVQRAGVLVQGIDPQGKEVEMIIPDRRVSFGSVVQSQQGSMGKRKHKKAPKLPKNYAGALLRYDPSKIQAIQSKELAKMRKEGRSADFRSRLFAKFTANKRFAQIVESNALPPKQMVNSSIQTSPVQSPLQSRRTWRLRRIGCGVESMDSFSTSEVNGLTTSRTENNSCSANDLDSLYSNTYFDLRFGGFSTDSVPHLMAQQNTPQVPNYQMGKQGGFEARRKFSAKLLGLFGRILPRGEECGRKEERKQLTRMDSEATTSAEREAVLGEARLQSKNCRRPLSKCHSTPSSPPMSRALHRLNAFNNNRNNEENNPSLPTTPLILVTDPATTEFRPLTMTPHSTPILGSNPNLSGNKHSSKWKVVASATDAPPVVSPSRGTAPLHHWHLAKRKRFSGLPSFKRTESLSALNERWREMRRTNMAAVGRRMRSMESNEGGLQETGPTTKWGEAEPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUE7</accession>
    <name>A0A914HUE7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUE7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3869.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3869.t1"/>
        <property type="gene ID" value="Gr19_v10_g3869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3869.t1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43041" checksum="CBBF46F5F91E168A" modified="2023-02-22" version="1">MGKEKWGREGSPKDFGVGQLRSLLSNNGPETWEIGKNCTGDGGSGHQGTNASDDQHGDVEQKSEWINGLFLPSSWRPSIWLYLPPNAADIFLWANFTRLAQLDQNGIGGALGRFKAAKGLQKMFWGDTVRIHEKKGFGGGTNRPDLRVTGRRDVKAVGRGGKSICDVKDKTIVKGRNSEFIIKKTHVRVGLDGKSTCHVEVKCTFSKNRNHRFRFTNKQIKGWNDFAKWFQWGTKREAATTELPHEFQRGLKPRQRAFASTVKFVKNGLRVLNAAGVFFDLNNVGEAWEKEGFMAAVRKGGEIGVVRVGQTAAIGIVTAAAVAAGVPLIPAYVCQFVTGVLAGSFLESLMNANGGTQLTGNEVVVKNEQTPEEEQKNEEKRRSLSRNFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUG3</accession>
    <name>A0A914HUG3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4774.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4774.t1"/>
        <property type="gene ID" value="Gr19_v10_g4774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4774.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10476" checksum="CB6CC663A59C8268" modified="2023-02-22" version="1">MNETQLENCKMKLSTLVGEEELVTLEDLFPEVLQIGEVRILRDIRHENIVGVLDMFTAFLGAELAPVPSEEHTVRCDGGHRELCSFVVECQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWU9</accession>
    <name>A0A914HWU9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWU9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4754.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4754.t1"/>
        <property type="gene ID" value="Gr19_v10_g4754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4754.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34743" checksum="F885AD6172BB2728" modified="2023-02-22" version="1">MPSANSLLKPIDFVNFGEHLVVLLCKFVSISLLSSLLLIAHFWPNKLQVNGLSPAMRLYMCTHCACSAIAIPYQLYTLIWAVLQFVEHPEAPASPYSPQVLFWTGIFEGNYYAVAPITVTFLAIERCLTLQFGGVNSNFSCINKLLCAVGGLVILVAWCASTVTYLTELPLQLDKVSKCSVVSCLAIKTLSLAQTCIKNTFGLLNICFCLIFLRMLRSFSAAKNMKDRVIKFTIFAEIAFNVLPGLVILIFNSATSISLASYAGEIGITFCNIDAFVCSIIYWRLLMKPNAASANAISTHPPKTTAIWAVRVNSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX99</accession>
    <name>A0A914HX99_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX99"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4988.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4988.t1"/>
        <property type="gene ID" value="Gr19_v10_g4988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032006">
        <property type="entry name" value="TMIE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28635">
        <property type="entry name" value="TRANSMEMBRANE INNER EAR EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28635:SF1">
        <property type="entry name" value="TRANSMEMBRANE INNER EAR EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16038">
        <property type="entry name" value="TMIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4988.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29439" checksum="E662C52506DD6B66" modified="2023-02-22" version="1">MDASLFALTNIGTPFPEGDRTRPGGVMAFCDRPRALRWVCVTTARRLGADPLGRWSRDFPQNIWQSLRHGLPGNSRVRVVLYQKRSGWPCGHGTAGQDAVTADPVPCPRWETVPVPAMQLSAIVKAKHNSDYSSAKPIFLSMIEQQQQFHPLDQYVAPGLRLWMLIGLVSSVLLVMVVIVCCFVRIRIPRTKRQIELRAAKRRKRRALRESGGADCGESQEGEHNQYRGAQTIVLNSFTGASGGGGGLRRSGNGAVAGERQASRSIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXD8</accession>
    <name>A0A914HXD8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXD8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5539.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5539.t1"/>
        <property type="gene ID" value="Gr19_v10_g5539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036673511" evidence="2">
        <location>
            <begin position="21"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5539.t1"/>
        </source>
    </evidence>
    <sequence length="455" mass="49654" checksum="5340A89826C73E61" modified="2023-02-22" version="1">MVRNLCLLLLTTHCLSGLIAVNAASDDELEKKEPANEEAHSSIDTEPKQEDQQKAASIDTEPKQEDQQKAASIDTESKQEDQQKAASIDTESKQEDQQKAAFPHPEVSTSTQKRQPKPLKSPNFEYNDAFPTSSSSAEGDNNSADEDYLATESEAESNGAESLVKSSSSSGEDSDEWFMNNVAPTKSKARKSSLALGPSKGPNKSGKKPNQPRGKTMITLSSSSSDSDQQQKGKATIRSKKGLAHKASIQQQKQGGPKVILPKATSQRKDKSAATSRSPSAGEKASGKQSTNSAEIGNSSRKGKGQIKSLSDAEIDEFIEKLKLKHNSKVKKNKQSSSDEDNKSKKEMKRKRKHSSSDEDNKSKKEMKRKRKHSSSDEDNTSKDDTESSDNSLNFNSSDDSLNVSSPEEKETPKKGKRTTQPQNKKQSAKKVESKSDKAGGTKATPTQKRQKKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXH2</accession>
    <name>A0A914HXH2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LAGLIDADG homing endonuclease</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXH2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4694.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4694.t1"/>
        <property type="gene ID" value="Gr19_v10_g4694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4694.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12380" checksum="9869033549D8C171" modified="2023-02-22" version="1">MATKVGVNLSEIKPSKFKNRFELFKLMLQLFKYTNEKNHLMEKEMTKLFGFAKSFLQESSNSILNANKTKQRRHKRELATNNLSELFLLWYDLENRTGKNSVNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYD2</accession>
    <name>A0A914HYD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DM13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4931.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4931.t1"/>
        <property type="gene ID" value="Gr19_v10_g4931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036696791" evidence="3">
        <location>
            <begin position="34"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="4">
        <location>
            <begin position="914"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4931.t1"/>
        </source>
    </evidence>
    <sequence length="1048" mass="113041" checksum="0A10BF4BB958FB98" modified="2023-02-22" version="1">MPWDGRRPKILPSSPFAILFMFFSLATSRDSGAQSPSSFPSPKFALNYAAPPADGTEVPASERELAQLAIQELLQLQREQQQILGTEKSTDRQKTTGIWPYSLYEQQMAKIFGERKKGATKEEDFLKSNTPVIIHLPAYRSTAANGGNGAGGASTWTSQGVKSKFARVGSNRSSQGSNNNPIRPQSNRWHRTSNGEEEKVGGSAYSSVFGAQPKGENRLSNANRITSRLKSSSAEHLLITRPEAMFTPLHAHRNGGHRPAQLRPIEPINNSPPGHHQKQQQQLFIKNVMPSGALMPNANAFTDGNENTIIDQLGRTDSEGGNKRLSPPISAFVPGGGGALSSSASVSSSNLASSNLASSNLASSNLASPLAAAQPPAPLAGSPFDLLASSMSNSGAVQPNALLSQLPNPLQLLSQGSTLEQITSLARNLIQMSNGKNDLLSSLSKAIGSPASAADSAASKLTSTAVQSIAKSASKVAAQGERTAVVGTNNGGDVLKTLFSSSAANGTTGTEQEQKELVLNGTSSDLFNGLPAEQRILLEAAMKNGELDLPQTANSKTELNEETVGEAFRTKLVNSESRLMEWIQQNRPRPPSEQQSPQAIFPDKTVAINGVEKLPYYGKYCGHFVEQTNLSRQHNVAGAVWAIDERRLLISNFHFQPFEHSENVTFWAGPAKHTGTSQDFFPSENGFFLPPAKLDANTFALWPAQKRPAHTRAPILPINGKDYYGVNGTTGTGKTAEEEEEETAGANRIGRRKRNLYSELYEQMAPEGPTSTTTTTARSVAATAVSATNERGGFFGGTSTATGGAVVPVHFDGMPHNFHIRGTTNDNNGLAIDPAAEEVHLHEECHWGSLGWHGGNHHILLTLPDNSLIKTLNWLSIWDHSQKQTVALVLIPSSAAGATFQPPSSVQLRPLLPPNVSTGKRVQSGPIRVLNTKTIELTEFSLSTEGLPMWFMVGKEIVPNRNGHIVPIFNRTTQSFDCDSLRDFHNETVTLRLSDPLDIKDVFWFSVYSIPRSQSLAHIYIPYNDMQLPPDLLALPTPQCVWTPPSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYP3</accession>
    <name>A0A914HYP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5010.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5010.t2"/>
        <property type="gene ID" value="Gr19_v10_g5010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000020">
        <property type="entry name" value="TBC1 domain family, member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF547">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="472"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5010.t2"/>
        </source>
    </evidence>
    <sequence length="804" mass="90071" checksum="A24486999CAD5DD9" modified="2023-02-22" version="1">MAANRLNDLLKKAHGAIAQLRGGGANYFLGKNGEVIFSKNNVCVHETGGDSGEEEAVHSPGYLTIHCSEDEQLGITLILQWLPNALLEKTPSSLLYLLYLLCIRCVSPLRGRVGDEKEEAGGDTKNSAQVTRFTCSNRSHTVDSDDGENVARGEASSAVVRCEVLNGALDEHGEEGQSQLRPQSLIGLFIPSIHLIPNTPVDQQDVEEKIRCDRSESSEPTSGEDLDEEEDKFADAAGDCYSSSGDDELEELAKTKALDAIRKSCAVSLARGAIPEQFAREHNLMLTTGGGEEGGGTVAADAGGPGMATADGPRQAVVFQQKGRRRQQRKSGDGGGSFSSLFSVNLGKMRSMRVFYSDTERTSGQLVIASPDSQYKIFHFHHTGLDKLTQLFERWNAVKAKSAVGNDSPTTNGQERHLLISPGAETELSRTELDPEDGLYERLGWEIWRSYVSTDGSVEDGFTIRKTVYFSSMEPSLRKELWPFLLRIYPWNSSAEQRESIRNELFLRYQRLKGQRIRRMAKPPPPPGEGVPQQQLAGVAQSIVKDVLRTDRRSSFFAGEENSNLDTMKSILLTYAVKNPEIGYIQGMSDLLAPLLCTLRDEPLTYWCFVHLIEQTLFRQPNRDEHRSEMDVQLEYIRELLRLFTPNFHAHLAKLGADAPNLMFVHRWILLFFKREFPSRDSLHIWEACWSRYRTNYFHLFIACAIVSIYGPDVVAQNLPHDEILFYFSSLSMHMDAHLILRKARGLLYQFHRLPRIPCTLAGLCSHETGSDQWTSHIEPHGQFECTQKHGENGEEQCPFATVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0I9</accession>
    <name>A0A914I0I9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0I9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5766.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5766.t2"/>
        <property type="gene ID" value="Gr19_v10_g5766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5766.t2"/>
        </source>
    </evidence>
    <sequence length="95" mass="10724" checksum="4FAA31A52DD4487B" modified="2023-02-22" version="1">MSLNANHLVASRFGEIDNVQRTANDQRQLLNEARAQNVDQYRQLNWSSTFQNCASSDIFGNEANHEMGWAQLLNIPFESELNPTANVENGRNTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0R6</accession>
    <name>A0A914I0R6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6424.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6424.t1"/>
        <property type="gene ID" value="Gr19_v10_g6424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="11">
        <location>
            <begin position="699"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6424.t1"/>
        </source>
    </evidence>
    <sequence length="1513" mass="172187" checksum="654DB292E5BEDF92" modified="2023-02-22" version="1">MVYPTVAMIVEEGVKIEDIPEYKEWQRRQGLPRSTPTSPKTTTPPVTKISTGIQPCKDRPANDNFLGHIYCWALFALYAMMMFSLIIYQLRSILWIKQRGHPQNSSHSSSPSKRNSPLHHLHLYCSGMDSNQISQILEANPLTRRVFHGCFPCDRLPNPQTLQPKTPTALIVNLDPEGMKGSHWIAIFVNGSRERFVDGPSTHFFFSYPYSYLIHCNSSSPNGRSAFRKACPSWLCHRRTAQRPALFCTASNISRLVAVDRQRRTPEDYVRKLDEDVEHSAKFKRGQAPLDSDVWTPIREINDNTVDVILNRFLSVVQSKQQNNVSLLGGPFTVTVTTVSRQELPAVRTLKGSARRPNQTVQHQISEHALIKIRNQNNHCLFLALIATLMHNISKWAPWKFFDYINGRYGSAGQFEQDTEKLMRCVGAPLFQNGYEASVWVPRVVDYWNNECYVNEHSIKVYIFGESGRYKPLFKYGPDSYTAILRLYFNNNHFDGVKTSGRLFGKPYCLSCEVPYDKAANHTKSCKARCMLCGRVGPAYPCIAEEGFKQFCSSCNKTFTSINCLQHHHLHSNFCARSKKCLECGVIWDVKANTTQGRAGHKCNERFCNTCLGYHSKDRGCFIQPLEPKHGKPYRIVSFDLETMQHVVANPEAAAEKQKKIHQANFIAAKVACPKCIYNGCWRSSLTDTPCVVCGPCRTITFNHQPFNDTKVDKADLFRRGLCPQMIRKGNKMYEMKVNRQQGSNPNVIFRDSYNLMPCSLAALVPAYGLDVVEKPFFPHLVNRPENYGTLVWPTKDDYMANGMMPAKRSDFDKWYSQNKQHPFRLEEALASYCVNDVEILMCALVAFRTEFMEVSKRGSGSMERAAFKSSHNGIDVLREAMTIAAACMRHFKINHLRARHLAIVPEKGYDNADNQSMLALKYLQWYSEKHGVKVQGAHSPEMEKKIANYKVDGWVETLGRAIEVNGCVWHGCSRCYPLDEQLLPNGKTAGMTRQLDASRLAFIRSQVKEVEVVWECDIRKQLEKDGKMRSKFERYRDEGPLSIRECFTGGRCGPRKMFHGVQPGQKISYYDVTSLYPFINATTKYPVGHPKVHVLNADVSWTLPEHNPYQLALLKVFVIPPRTIDIPVLPLKADDRLIFGVCHSCACEYPNGGVLRDYSCKHDDEERGWVSSCTSIELNAALEEGYHVTKLYRVLEYTQSDDTLFQPYIAEFMAQKLHASGFSDEIKGCEKAEQQYVSECAERFGIHIDQQKMVPNKGKRSLAKLALNNLWGRFSMRNELTQTFVTSDPVALTEHLDDRSKEVTALDVLSDSTMMISFTTKKEWLEEHGCSNIVVSLWTTSAARLYLLKLMQKIVRSGADLLYTDTDSVIFCHNEAANPLTLGPHLGDLTDEYPQHEILEFCCGGAKQYGLKLRRKDNGEIEHVLKLRGITLNYDVKINQNLCYTTFRERVLLYSETGKLDPIPVFTNSLKPNIKKGEVTSEKTSKVYKPYVGKGIVGTDHGIRDFGYIRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I198</accession>
    <name>A0A914I198_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Groucho protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I198"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5947.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5947.t2"/>
        <property type="gene ID" value="Gr19_v10_g5947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF21">
        <property type="entry name" value="PROTEIN GROUCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="537"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5947.t2"/>
        </source>
    </evidence>
    <sequence length="699" mass="77421" checksum="A61FC65D5BA1F595" modified="2023-02-22" version="1">MSISAESTNEGDIFQKTINSSTLSDDFDFVAQNGNELGEADTLGGQHEIEEEMKMELKEVKEELKQYKEELKGMKQLEGELKQYKEEFKLNMEELKQQQNQTEKIVSDQFLLMQSDQKALLDRIAALEQKQAANAEQQKADQKGLSATIHLSLLHHHHHQKQQQQPPFSGATPQGMNPLQPLGMNPLQPQGMNPLQPQGMNPLQPQGMNPLQPQGMNPLQPLGMNPLQPLGMNPLQPLGMNPLQPQGMNPLQPQGMNPLQPQGMNPQVAQPQQQLFQQQQQHMTAMARQVMQNNDVQLLMSRFKEATQRGPDDVEAFFVELRKSPHLLNAFLKHTKKQNVNLPGALPVHQHAYAFKMCPGESMMPALFPNDASPHGADVPKSLKQIGDLPHGDVICAVTMAQNGRHVFTGGRGTVKMWDIGERLGLVASSTAAGGTNGGRVGTQPWSPVNTFNCLKDFYIRSCKLFPDASTLIVGGETRTICVWDLNSEKVKTTLDCEAEACYALAITPDCRLCFSCCSNGSVGIWDLHNELKIGQLDGHTDGVSCMDLSADGVRLWTGGLDSSVRCWDIGERAELNKYTLESQIFSLGCSPTNDWVAVGLENNTVEVLHMNNRQQQEKKYVLYGHENCVVSLKVAHSGKWFVSTGKDSVVNCWRSPYGYPLLESKESGSVLSCDISSDDRFLLTGSGEKKATLYELSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1M3</accession>
    <name>A0A914I1M3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phlebovirus glycoprotein G2 fusion domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1M3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6476.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6476.t1"/>
        <property type="gene ID" value="Gr19_v10_g6476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009878">
        <property type="entry name" value="Phlebovirus_G2_fusion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07245">
        <property type="entry name" value="Phlebovirus_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Phlebovirus glycoprotein G2 fusion" evidence="3">
        <location>
            <begin position="316"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6476.t1"/>
        </source>
    </evidence>
    <sequence length="567" mass="62576" checksum="D1D72295DFC195CB" modified="2023-02-22" version="1">MALCLISLIGNAIANSTCPECLLHCSMSGVTIYGPSGNQKLDVCCGDVCIVRNQVRQLAYELPPETLLADYTCVARFWTSPKTMFVSSVTCPALNECTLLSCTFCIELLANPSCSPEVAASLWAIILVGMLVGLCGLLSLCRSCRENFRLMMALLKPIGACLRICRRKATRAHTRARSSLPKRSDRNPLHGQQSHHAHIAPGGTIHNPNGSRRARSCARNAQFGAERFDDGVRDQIGGMVPLIRRGEQIKFPLPESSKQQLFWQHVRGGKTGRQTMGIERRKRLARPLALPGQPRELGKGMRALAFERLSILPHLEMNSDSESNHETEAILYPGMHFHWHNITLTPLAISLPPAPILSSKFITSEDAVALVEQLGDDLHCSDEASARDFNCTLAPTACSGCSADHETGVVGCSCRDLNLEERIDDPQQRLPLTIGQFHLRNEESRILADTGYSPVQLHVEMRDVEMILQLRDSKCWIEALNISGCYRSLTGAQFWYQCRTDWGRALAKVECADGTIFAASCSTNQSAQREVRLSTVQLSTVGLSTVQLSGPHFNTLSKSDFYILKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3P4</accession>
    <name>A0A914I3P4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3P4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7017.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7017.t1"/>
        <property type="gene ID" value="Gr19_v10_g7017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7017.t1"/>
        </source>
    </evidence>
    <sequence length="806" mass="90149" checksum="B72BAEFC7C0932C2" modified="2023-02-22" version="1">MQSSMAETGEQQRLRYALCVGVVGDECQLIFADDLSSVTLRPRIGECRLGRWFRMASLPDQYQHFSLLEHENGPFTTRVVGDGFSKRVQVQLPICFVPDLSAFGWHAMNDADRNKFYSPHLEKAGQVWAMLDWSRIEPGHRYEALLSVEIDSIRQLPRWTLDSADDILGFSKLFAKTGSFGVPTSAGVVLRILPEYDRNGHCLVTIRRHVDARLAFGRIWNQNLSVGDIVDFVCIETCCRSLPLMMALDIAKSVQPDSGKVRAVEFVSDDLFKLRVPLSAQLLAGLRDNRRVAGSLELANHGTLLDVDNVIGQKLAAMPKDVEGGVAGCSFYANIRARLCLVPEKITPLWVLVGIESVERATDFGDIEDVQATTPMTASTTAAVQSVTAVSATKQQQQHVVVEAMEEEGTAAVDEVGEEVQEAEEVRLEEEALVLFTHIVRRDLYMRFFDDREGKFTRNKCCNRDDLPPNFDTSDPPMPGSWAHIVYTVDCARDIQHIVIIGLRPVDLVTTTENLGAILRYAMMTVVPSNAHVWKTLLETTRVCTVQQLLSGAAGPAPTAIRMGLLKLNSPPVLMTGALNLIGRMLSMNGRWLGLGMARIACVDGSVANDENSVPMSSSWAASTSAPASRTPTPLAKVNPSAQFGSTSKSVFRKMAFANKETKKQKKNREKKELQQKQNVQQPENVQNQSLSTIVLFIKSVGFEQHMRFYCTEKVTFKQFRCCKRNDLPECPAVGTWARIVYTNISDQHIRVSFFKKLDYDETRKNALTWAMKLARPENVRVWNSLSDQKNDWPMWQLEKINRSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3T3</accession>
    <name>A0A914I3T3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3T3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6560.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6560.t2"/>
        <property type="gene ID" value="Gr19_v10_g6560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053322">
        <property type="entry name" value="PLA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228">
        <property type="entry name" value="PROTEIN CBG09474-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037596226" evidence="1">
        <location>
            <begin position="23"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6560.t2"/>
        </source>
    </evidence>
    <sequence length="503" mass="57965" checksum="52D79B466BD8B4F9" modified="2023-02-22" version="1">MFVKNLLNFLVLLMLNLHIARGGFLDIITTTPTKIMYGVLTGNYGKMLHTYVETVEKPVTYMVATTGVLEFRKHPHAAFFACGPDNNQFAKHLAEFAVVVTEGCLPKIDAMHACCLEHDACYTRLGVSQDECDKPFCNCMKVATNGSTGANKSQTVGGNYRDNGSCLTDIAIDESKIRRRIMINESNHFFCDFILNIGNFKCISWPKFHEIPLALLLASFASSGAPTATFMSKIAIYTHIYMLRWKLDQNKEQLQQKVLEKENKYISFYQQHSDNLSKILTLFAEMALYDDALCFLLREWMLSDLLNFIDQRHKLLKYFEMISKSNIRAVNKLRELFIMLVGGSRVALLCNIKELSFICAAPFTPYALMYSDYFQNKKSEIGKWRSKMVLEFSLYNKWGTNFFKKQYVKIRSEAADKCKYIADCVQVQTNFLTIMFKWWVSYSEIFWYNEKKIRAKIVDTLKKTRAKVNLLKEMITKADEHEPALQYAVETGDEKGEVRSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4X2</accession>
    <name>A0A914I4X2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with SLC30A5; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4X2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7550.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7550.t1"/>
        <property type="gene ID" value="Gr19_v10_g7550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052005">
        <property type="entry name" value="CDF_SLC30A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531:SF1">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="13">
        <location>
            <begin position="39"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7550.t1"/>
        </source>
    </evidence>
    <sequence length="409" mass="45043" checksum="876C988959686C0B" modified="2023-02-22" version="1">MQCTKSYRDIKQIFPLQNLISECTSVLIDPVSQKACLCFAASAFLLAFLIYSVSATRSLVLTGLAWLGVFSLFVIFSTIVAFISAAHRSANKRYTFDMARAPVLAVFSTTVLAQLSAVFLAKEAVERLFDSGQHHHSHHGGDAAALTGGDIVKTDHLFYPAAFASASALLIVAYALANQPFNYVLKHAQSSVIQEHSADICAAICYFVPGLARLLLPRINSLTLLAFISACCAVFVHWFRAEFPWVDSAATMALSFTIFTSMAPLSSYTGRILLQTTPPHVQNLIDRSISEASTVDGVLELINTHFWQLDFNTIVGTVDVRVRRDADEQTVLRTVRNKLSSVVNYCTVQVLKDSSTGWAYHRQYQSPLYQPSTTASAHSDQSATIPHTHDHHSNDHHQHHGHGHGHSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5Y1</accession>
    <name>A0A914I5Y1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g6920.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6920.t1"/>
        <property type="gene ID" value="Gr19_v10_g6920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF49">
        <property type="entry name" value="AXOTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="191"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="770"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="933"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6920.t1"/>
        </source>
    </evidence>
    <sequence length="1336" mass="147424" checksum="409BB086C6F0A98C" modified="2023-02-22" version="1">MSFTQSHFYTDSSLSSRMSPSRGGGAVHGQETVVVHKLTINILSCIIFFIFFFFLAHAATSEEAQCFEQQYANRMVKFGSLHVVRRVGIISPLGAFYLAHFIDEEDAVKEFRHSSLLQRHLTRQANGELLVIYSGHSAHSLEWARVDLLASALRLEPLLGGDDIQQHVSPVLLVTACPAPVLTVPVSLPAPYSFKTRSSASTDEQQLISTNISPAYENELRVNFKTFQNALFLYSVADYGDHLIVQLAGGRVEVFFDFGGQQQSQLTGGLALNDGEWHELRWSHHFDTAELFIDGVCMNSTEIGGLYRKLDLHSTVEIGGRPEEIGDEQLPLCQMPQPQLVAIGLRSALQIPYSFLPFAFDFHVLLQRPQLQQQRVGAVPGRQHGAEDAVALLSILDTANATLLQLSIAELDNGALSIRTSLGTGGQAPRVVTLGGSVARGWHAVVVKLRGGDALEVEMDGRAAYWVEGPAARHIGMTMHTFLLSATGCYRSATIDLKQGVHIGDEMIRDTCPLVESCSPNPCQNGGQCVQNGFASFICECQHNYTGRFCHISKLPHSCEEHFASAGAVSKRVLIDLDGGGPLQAFIVECRRRGRKLRSKQDGAIEEVITVIRHDAPPQGIIVRGQSEPGAVRRILHYGLDEPVLDRLVAAFDHCGQLMRFQCVGGQRLMHYGAENRPSAWYATRNAQHGLQWGDAPPFSRMCSCALNDSCAGQRSCNCDSGQDAVDIGTNTHHQLLPILQLFIGGGTEPKAMANVSIGPLECSGRYVFETITFMDRNQRLIASHIFPSASTFYATLSIRLARPQLTVFTYTSANHERWFQLFVRAGHLVGQLVYAGISHELVSDVVVDDDRWHTVSWEVDELSMRLVVDRAEKTVFAASVPPRASVLIIGARTGKDRSGFAGQMRNFRLNGAEVALGQLAQRALGAGVQLGAWGACEVQNACRNDGRCVELYAAFTCNCSLTPFSGDTCEDEVGMWVPLGSELKIAWQHPAQMSNCYRISIQSASTGVALIRAQALFAESNFNMSIDRQGQLNVQIFDGVFFAQKVTLSPRFVIADNKSKDIRFCANSTGLEISINGEQALMLEGNFTFFSVLNSWKFVDPNFSGCIARLMVGDAFPLKDPRGSRLQHSGKIRFGSCPYDNLEHRKTQSSLTTTESREHDVDLSDIHATSSNFMKSQRQLLFITPAIGFASALCILLSLCVFLLYIQHRPDVGTVGDNKRRHGNGNDYNAEGVLFTGETRDGAIHPTRVLLLMGHASQMLIRFVNNPDMPSNSVILDLILRWVVFDDPPMNPEQHVSQSYLVLALEFMRDRLLAMHHKSFVLIVQKMFNLFFIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I682</accession>
    <name>A0A914I682_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L37a</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I682"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7.t1"/>
        <property type="gene ID" value="Gr19_v10_g7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10106" checksum="BBD2478CAC011212" modified="2023-02-22" version="1">MAKRTKKVGIVGKYGTRYGASLRKTVKKMEVSQHAKYTCAFCGKEAMKRVAVGIWNCSKCHKKVAGGAYVYATTTAATVRSTIRRLRETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6S6</accession>
    <name>A0A914I6S6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6S6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8026.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8026.t1"/>
        <property type="gene ID" value="Gr19_v10_g8026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8026.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="42332" checksum="2776DB73A63494A1" modified="2023-02-22" version="1">MICHRIWPLINDNIYGLYLSPTCFDHLRQFYPSVLCNCTNLRFVDAFGRFPEFPADDSAGASSAQALAKWLHSPRGDGRPNVLKCVYPLKGMKRFKRAFRTSSISANFIAYFWGRSSEEIVPFDLKNNLTSERLELRHLNKDKVLLVRCPIKRDEVKWAKWEKEAIDWKCHQWNWVDIAFEDMEIGDDDLECLRQYSSTVLDDCAKLRLVYAMDLFPEFPADDSAGASSAQALAKWLHNPRGDSRPKVFIYAGRSMPLEALKSQFRNSSKKTANFITHWGRSSEEIVPFDLKNNLTSERLELRHLNKDKVILVRCPIKRDEVKWAKWEKEATDFDWGRQWNRIHIDLKDMAAEESSDDDEDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6X4</accession>
    <name>A0A914I6X4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2</fullName>
            <ecNumber evidence="3">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Dual specificity Yak1-related kinase mbk-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Minibrain Kinase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Through phosphorylation of P granule components including meg-1, promotes the disassembly of zygotic P granules in the anterior cytoplasm during zygote polarization, and thus plays a role in P granule distribution and segregation in early stage embryos following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914I6X4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7859.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7859.t2"/>
        <property type="gene ID" value="Gr19_v10_g7859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000127">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF112">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="350"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7859.t2"/>
        </source>
    </evidence>
    <sequence length="691" mass="75611" checksum="4AB9A75E9DADF7EE" modified="2023-02-22" version="1">MHAENATAIGISTSGGIDRNATFNTNNSTTNSNYSALSLISHLCSADSPTAAGRFSIKKKLSETLFSSRSPRHTLSSSAIDLAAPTLLSKFTAKRNNEKCSSQESLRSISSSLLFNSAAIAPSSARSPHTQSNANHRRRPSQHSPSGDTATSSVQSLNPSVGEQQHPYTTTAEPCNLAFATVVAAATGGYPTKYGSDGEDTLFCPNNTDNGLPSLSITTASFLPANLTTSFGGVLPASGPITIAATSGGYEPPPGGPTTSSSTSSASSTSTQGLNASGNKGYRPDEALKIFGSKLTPYEHTELFNYQRVYFVGSQAKKRPCVAGGANNSNFDDENGSYALVSHDHVAYRYEILKVIGKGSFGQVIKAYDHKHQHYVALKLVRNEKRFHRQAEEEIRILDHLKKQDIEGAHNVIHMLDHFTFRNHKCITFELMSINLYELIKKNKFQGFNLTLVRKFAHSMLQCLELLHRNHLIHCDLKPENVLLKMPNRSSIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGAKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIVEFLGMPNPKLLEGAKRSRNFFSSKGHPRYCQVTQLLDGTTVLTGGRSKRGKLRGPPGSRSLHSALKNQGDDLFLDFLKRCLDWDPEARMTPGQALKHSWLRRRLPRPPAGAGPDTTDSALLLSSSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6X8</accession>
    <name>A0A914I6X8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">V-type proton ATPase subunit E</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6X8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7863.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7863.t1"/>
        <property type="gene ID" value="Gr19_v10_g7863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7863.t1"/>
        </source>
    </evidence>
    <sequence length="455" mass="52653" checksum="C08A6E1219722322" modified="2023-02-22" version="1">MGISDNDVQKQLRHMMAFIEQEANEKAEEIDAKAEEEFNIEKGKLVQQQRQKIMEYYEKKEKQVELQRKIQRSNMQNQSRLKCLKSRDDHLNNVLEESRANLSKISADRERYPAILKGLLLQGFFQLLENKIVLRCRKKDEELVSRILPECLEELQRTWGNRSEVKIDNEHYLPPDSAGGVELLARDGKIRVLSTLEARLDLIADKITPQTRTALFANGRWLLSSNRPRRMFSPKSVKTFKTETNSQQMESDCVIIVVIKANQSYSRRTRIKGTTNCVFGCYGTVYAFIRPPVAAVFYPQYFYCHRLSSARKMGEVRFQSEYISSNRGITKVIQIVLGFVVCSVLCSNWYGGYSCFGEGRLGYVSGLNFLCLLINIVLFLLNLFNIRPLKLEQLYNVVAAILFLVAIVLLLWYMIQNSYWDVWMIIAAVCVLVVFLLFQWDFKGNRTMSDGHLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7E2</accession>
    <name>A0A914I7E2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7E2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7438.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7438.t1"/>
        <property type="gene ID" value="Gr19_v10_g7438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7438.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8284" checksum="FCAF300EA527D49C" modified="2023-02-22" version="1">MIWRFRKRRRENTDLRRQRRQSRENGEEIVRRDVTPEKAEQREETHKAIALHWKAKAQSGRADYVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7G6</accession>
    <name>A0A914I7G6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7G6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8206.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8206.t1"/>
        <property type="gene ID" value="Gr19_v10_g8206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8206.t1"/>
        </source>
    </evidence>
    <sequence length="1169" mass="132073" checksum="885FCB3F21C1178B" modified="2023-02-22" version="1">MNGVGEREASDSAAESISSELLINVIRTLTTTVSNDQRQLEKQRIEQCYRQSEQNIDKLLKEHRSDALHCLSTFQSVSKELTSSREQIRNIKSSLSLCKTFLQCRRDDLNKFWLENAQQKKVCDILQQIQQIKKIEKTVDVQLANGEYKEMIRVLKDADVLLKGPFDKMEGISQLKFVVSENLQKVFGQIVNDLLQCVFVEPFEAQTLEAVKSGKMVESKIGAALIERYPKKKLVALNDEGALRLRLAELLQSLLVFGQVDKALDEMFDRMPNLFLRLSNGAAEVVKQSAGGERSAGERDASHLAKFVNIAIAQMSFASRNFALLSLELQQLSHQFLPNCQPIMKRFWHIVQVGFEEILAEYLLVWRNKKDGNDGAGGGGVQKKALFSFENASFVSSVNASSRKKQFCVVCTPDIYNVVAIFHKLSALCREVESQLGEDCCYLSVYLQTFVAEAFLEQIRVDLERQTESVLNGADLWSSMSDVPPHTQRILSCCVRVFELCERINGYIVSMEPYALRFASFWLLILEHFIKGFSDKYFQIVMLRQVHADGGWADYPKLSAAWVVDEDISRLLMSLPSWSAVKKSPFSPDQIQTPFAADVVNLANILGESEQEIRERTQRESEILIGNLGTQKQPKSSELITSMDHIKALACLHESLQWFVGKMRALVDGLSSRAKELTKTRIQITTSGNGGTLIDQMLCEAIAERINTLEKLSDNLLLILHLELRFHCFFHLITITQNQSALSLLSQDEIDRDVMEFGRDLSQFHATLHAHLSPTKLKYLFDGLGYLCSSIFIHSCQYLTKLSEMGRKRICRAIFSVQKYLSQLSGRPETELQRAQIFFDFLNKDLDQLFATIVERGAVFSFVEYSILLSLLIRSHSTLNSQPGVLEAATNQLRDILSHQQKGKPNQKPISSMVGTEAANFSLITHVIFDLDGVLIDTERHYTTANERAMEKFGSKFTRELKLMMMGRKKSEAVPLLLKDAGLAGRVTSEQYMEEYDQHLKQIMSTLTEVQLELPGATKLIDHFYAQNIPLAICTGSDSEEFGDKMRKFDKWLQKIPIRVLCGSDPEVRNGKPHPDAYEVTMGRFVSKPVSPKNVLVFEDSINGVESALGAGCSVVMVPQREFLPKDWPEKELRSRANFAALLDSLEHFCPKPFGLPDFRLREGGGCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7T4</accession>
    <name>A0A914I7T4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Golgi phosphoprotein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7T4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8290.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8290.t1"/>
        <property type="gene ID" value="Gr19_v10_g8290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000004">
        <property type="entry name" value="Probable VPS74-protein involved in protein-vacuolar targeting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8290.t1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36384" checksum="147868AF2BAED495" modified="2023-02-22" version="1">MKEKRSKKNSALKYKTTGLVQRRRKVAESNNSTNSGQQLDNDDQTIGGGYTPVINAADEEDNDKMQRLTLMEEILLLGLKDREGYTSFWNDCISSGLRGCVLIELALRGRIELEKAGMRKKGFSSRKVLLKSDKMTGDVILDEALKHIKETPQRETVVSWIEYLSGETWNPLKLRYQIRNLRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLNDGNAKAKLVKRVQETVLSKWTNDVQRMDKKMLSLLILAHSSDVLENAFSPLNDQDYELAMKRVRTLLETDYEAESLKSNKQQSNGGETSFATAYDVIYAVFEAFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7U7</accession>
    <name>A0A914I7U7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7U7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7718.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7718.t1"/>
        <property type="gene ID" value="Gr19_v10_g7718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038163642" evidence="11">
        <location>
            <begin position="20"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="93"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="281"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="369"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7718.t1"/>
        </source>
    </evidence>
    <sequence length="509" mass="58305" checksum="9E0D2AF618D23A25" modified="2023-02-22" version="1">MFLSFLCNLTQIWPHPVNGVDVDGPTAVDGSNSEFIENNDVDYGIVHIFHEKRPEGESTTDRPFFNFNNRKSAEHNNEKPPRKTTARRNCTTQTQIIDKLLNGTGYNKYRIPEENGVDVAIEFWLQAISSISEITNDFEMDIYINEMWLDPALNFEHMSPCKQNLTLSHQVLEKLWTPNSCFINSKVAQIHNSPFQNIFLMLYPNGTIWVNYRVRVKGPCAMDLTNFPMDIQTCHLIYESFNYNNQEAYLVVEPYPAGMWDELHVKLSFERRYVWYFMQAYVPTYLTIFISWVSFSLGSKAIPARTMLGVNALLAMIFQFGNIMRNLPRVSYVKAIDVWMLGAMFFIFCSLLELAIVGFKVREMPSAHTRSKKTPAGPIMCNNRREEENGRGPMGNGPHNKQHIADGASDGDLSPKFGGTLVRQSCERRMDGDFVVRLQQRTPPLRFRFIALLNHFAPSQIQAESIDKVSRIAFPTMFALFNIVYWSYYGRKAAETSGELHSSGGLIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7V4</accession>
    <name>A0A914I7V4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U6 snRNA-associated Sm-like protein LSm3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7V4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7552.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7552.t1"/>
        <property type="gene ID" value="Gr19_v10_g7552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000007">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sm" evidence="15">
        <location>
            <begin position="723"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="404"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="614"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7552.t1"/>
        </source>
    </evidence>
    <sequence length="810" mass="93379" checksum="D47F53C6F785B717" modified="2023-02-22" version="1">MGKKAKVGKQRRDKFYFLAKEAGFRSRAAFKLLQLNKRFEFLQHCRALVDLCAAPGGWLQVAEQQMPVSSLRIGVDLVPIKAIKNCITLQGDIVEEKTRHAVRKELGTWEADCVLHDGAPNLGTNWAHDAFQQNCLTLSALRLATQVLRKGGFFVTKLFRSADSQFCEQYSKPDRVDPDLLDSRKVFSIQSSGTDENEKINLHRLLLHPNSKERKAKALGYDDDAQLGLHHELGATEFLASKSALQLLSRASELVLDSERVLNSEHTTAEIRECVRDIKVCGPAELRSILKWRKKLVEEQKKEEKASKENEQQQGKEAMVGGDVAVEEEESAELKELEEIDELIRTAKTDEKAMLKKRKKKLLKAKRKLEERKKLKMVHEGDEPTLGEDLELFSLRTVRRLAERAAKAAKGIKEEETEDDNEDEEQEDEEGQENDDAKDKTKTTTATKMEEFDDGLNEATEEYDDDEEEENENKMSSKGAKGQKLTPEQLAMGEEIIYSRKRARDLEDWAWNRYTSNDDALPDWFVGDEKRHCHLEPPVDKERVDFYAQRDRNALNTRPIKKVAEAKARKRQRRLRRMEKARKKAEGIVDNEQMEHGEKVRELRRLYKKAGTKEKREVKYQVVTKGKKGSMNRPDGHYRLVDKRMKKDTRRQPKRGKKADSKQRTKNAKPNGVGRSGKEKKSQDTRKRANFGKKKPEMIMKLQLFLVLSNIFDRMATLEAVEEPLDLIRLSLNERVYVKLRQERELRGRLHAFDQHLNMILADVEETVTITETDEETFEEIHKPSKRTIPMLFVRGDGVILVSPPTKYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I962</accession>
    <name>A0A914I962_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g8658.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8658.t1"/>
        <property type="gene ID" value="Gr19_v10_g8658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19497">
        <property type="entry name" value="RecA-like_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059067">
        <property type="entry name" value="Znf_ribbon_CLPX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003745">
        <property type="entry name" value="PRK05342.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26040">
        <property type="entry name" value="Zn_ribbon_CLPX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="696"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="866"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1302"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="922"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8658.t1"/>
        </source>
    </evidence>
    <sequence length="1394" mass="156457" checksum="95C381E4912ED05C" modified="2023-02-22" version="1">MRSQQFSLRQLRKPFRNATTTSNLGLRGHRNGIVGQGMPWTSSSLLATTPATVASADDNLGSHLVPTMTATKSASTVVDFRRRSLSCGQSNCAKCGKPLRSTPTTNVNRNLLYCKACNIVFSSSSSSDSSSKKFNMLKSGPIQSPPYPTEISAYLDKYVVGQQQAKKALAVGIYQHYKRLENNLRCQNQFLDNNLALAVQQHHQQQSQMHPNISIHYPFSHPHDLASDLLSHNAASTLSSNSLSSNQQRSKDPFYGFHSALQEDEPQIRLEKSNIVLLGPSGVGKTFVTQVLAKILDVPIALCDCTSMTQAGYVGEDVESVLQKLLQNAQGNVEKAQRGIVFLDEIDKIAATREAVSHAYRDVSGEGVQHALLKMVEGTVVNVKSGRKGQQECVPLDTTDILFIASGAFNGLERVVSRRLDKRTVGFGAPLLENTITADDKEQQLINQKRDKLFLQADQGDLIKFGMIPELVGRFPVLVPFHSFDKQMLIRVLTEPKNSLLAQMKFQFSMDNIELEFSVDALEEIAQLALERKVGARALRSIIERVLQDPKFDGPGSDIEKVQITKDYVRGEGTYEFTRKQLAMSTVALGVLFFTIHRLRHYLRLDRLRNQQIVQLEQQQKQQTNIVGRSPCSSSSTRSDRSFLPVSMDEAYFLRKFDEYERNDSWDQVFHKINLESESQAKKLSLCCDLSNTFNEKNRYRNVLPYDQNRIMLRCGVSSESDSYINASPLHLPFAHRNYILTQGPLPNTASDFWQMIHEQGVSICIMLSKVMEKSFVKCHSYFPSKEESKLEFDNFECKLEHEETKPHYIVRRIRLTPLDSLEERDCKSPQREQTEPGPEKGRIIHHFQFITWPDFGVPVHTDHFLNFLEEVRTAREKLLEQGEGSTTGPESPVVCHCSAGIGRTGTFVIVDSILSMFETKWKQQHQQQGDGEKNGSENDVSENVDRMADEQLDSLEALVVFIRRRRMGLIQTSQQLRFCWKTIVDWLVKNGKKAENPKKEEQSPEIQRLKMSLFGSSMNNSSPFGGKPGGGLFGAAANTAVVQPSTSTAMSQDIEVPQPPDDTVQSLKFNPMVAGAPIFLAGGSWDSTCRVWQINETGMVEPKAMLNVGAPILAVDWSEDSTKIFIASADKQARVWDLGSNQMAVVGTHNEPVRSCHWIATPQYTCLMTGSWDRTLRFWDMRQLPTQNALATIQLPERVYCSDMVFPLAVVGLADRHIKMYKLDGTPSEIQDVESQLKFQSRSIAIYKDRMTGQPGGFALGSTEGRVAIQCLQPKDPKENFTFKCHRSAELINNFQEIYPVNDVAFHPTHQTLVTAGADGKYSFWDKDARTKLKGSDALPMPITKVAIHQGGNIMAYAIGYDWSKGFEYSTANNVTKIFLHACDEEMKPKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9N0</accession>
    <name>A0A914I9N0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9N0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g878.t3">
        <property type="protein sequence ID" value="Gr19_v10_g878.t3"/>
        <property type="gene ID" value="Gr19_v10_g878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g878.t3"/>
        </source>
    </evidence>
    <sequence length="517" mass="59493" checksum="5AFE8AD030A7B8AA" modified="2023-02-22" version="1">MLLCVQNLELAINDDDAFFHFDYEYANGTGPPNFWYYGVLRDFHRFPTNMPPNYTAETRKLFSIHLWRLRTGLDFCGPFPPSAERVGTVNMRGMLGRRCWLSPFGCHFYALYLHRGDAIAVGDEDFFSGTEIPRNRNYQVGLMQITMGNNKGSSSETTMSLTRKDFALSAQPTPVNWQAIPSGIGRPKVECEHIHFVSATQFVLVTGTIEWVDQQSRRGPSFEGVDAKASRTQFHWISIDEANSIAYVSRIELPEPPLASRENFYIDDRRIYLHVRGDQDNRSAFVFYTLDWTRQLRVLNAETQQWEEFELDTRNSDFGIAEIVDDEGGTSADEFYSVRFDNGLLLRKHIDSVYSKQGGVVFIQLLPAQSTYIMRVMFKLSHLNVDARGSLMSVRIYPNVHDRVRVHLHIYVSPPYVAPLRYLAYWRLREMLQVNDRKEFDEEKGTMRSAAGYYKRMPAKHDPSSSGSLAIDELSVHNEKWAKLLQQADTAAADIKHSTMLYPIPWRRIPEKSGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Q5</accession>
    <name>A0A914I9Q5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9Q5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7992.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7992.t1"/>
        <property type="gene ID" value="Gr19_v10_g7992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039934">
        <property type="entry name" value="C2CD2/C2CD2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119:SF5">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7992.t1"/>
        </source>
    </evidence>
    <sequence length="950" mass="108639" checksum="C8D0838569B8DDD0" modified="2023-02-22" version="1">MDGLIWIFVAWLAVAIFSFYVFIHRRSTIPKVPTIQIDDDSSFTLETQHGFANDLLNWVLWGNSGTTLGMEQRLALSPVLAKFVLVSLNEAARRIDKEAAPIELQFDHMSRQSVDSEGIQLRSKESMFRNIHIQQNESPGNYLSIHTQLFYAQESADGGIMLNISASNDDQRTKSVQQDRVHMRKIPVKRGPSIKRHTVIIEQINGEVEIRLAFIAGELFVISCFKDRPTVQLRMTGTAKADEMLSYVKRCIISAVLNFSIGELLYPDTESTERASKARLSSEYRNLSFLHELYPSPQTPTQQKVSPRSMLPKFPIFVKDIRPEELASANRLKIQLVEIYGVNFEFDQQPFVCIELDEPNQRLLSVKADHQGHRPDGHKVYWDEHRASFEFSVSSASNELLFEVFFEEEQQAKLGSPNNIRERKFCGTAIQSLAELRQALQEQRQTIELRLQGRPFSYGERSRQSSQHQQQQEVYGVLVIKAFLYTYHEIERPSAPQPIERGVVEIVENCLQTRQPKSSSPFAYPGDQPPPLSPIKKHSTTGSESSSTIKRTKMRQKQHYIYNVTDDEGQSPSYDRQYAVGSSSSPDPYKTSTSLKQFEYQSTNNVNVEQQQSPRPVGAVRKTISDRNALFQYEPYEKTVVERKKSAPITKMSSSVTNTEQEKKMITKTETQPTQKQSVKDEVSNPNDFEQLFDKQKKLSEQKQQEQGGHPAMAIFEMPDKMKRLTVGNDPEEFERIARERDRKTEPKKRGRSFFEQVRARLAGPVRLLPGRDGKRAKSYDDNESRPMEEVAASTPTSRDQSQTRHIRQRKGSDHFEPMYNQQLFVNIDPENSIGGSAHQSTSNLIHSPKNVFENGQSQLVLELIGTEEEKPRYYSMPPEVQSEPAVIKLMQSGKKLHIYEGHIFVAVKPRGRVICALPSEDNMDVYKQQHFQHEYRGSGLARILEAQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA16</accession>
    <name>A0A914IA16_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CB1 cannabinoid receptor-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CNRIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IA16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8888.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8888.t1"/>
        <property type="gene ID" value="Gr19_v10_g8888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031718">
        <property type="term" value="F:type 1 cannabinoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029204">
        <property type="entry name" value="CNRIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952:SF1">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15043">
        <property type="entry name" value="CNRIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8888.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27345" checksum="BB50840C79E88F7C" modified="2023-02-22" version="1">MLSYFNFKQRKSKDDTTPFSSVPTSFSSIHSFSRPHSTCPLTFIRSSFVVVGPIVVRRHGSLIKDNSFNAGTGAVTLGDMEPLQSLQRKFSISACRRQSSIDLLAEHQFLLTIDGGRFDSSQFTLKFHTNTFYKIYVKTKPTQNFLSLNIGGNDLKLDPIEGGSGEYVAIWNTADKEPTKKGTRRDIEFVLSGPDKTLNKKLQVKFYSHNDTHAGWGQKLDQITWHCSPNDVGQVFVLEEQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB58</accession>
    <name>A0A914IB58_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB58"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8584.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8584.t2"/>
        <property type="gene ID" value="Gr19_v10_g8584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036734877" evidence="2">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8584.t2"/>
        </source>
    </evidence>
    <sequence length="195" mass="21564" checksum="563DF7E5F258B318" modified="2023-02-22" version="1">MPSEFLFLVVGTFLLIVPPIDTAVKSLKHFHGQQKPSTSKAVPPFDYDYPDYSAGVFIDAVPITSTTKKSLAGHRFATPMGLRRKSAHLWGGRQADRMVRETVWHAAEIMGKRSARFFIPGDSGSNEQNNQHQPGEASPRLDSSTIRILQLELRSLQSKPMEGFTISCDENNISAWTVGIFGPPGTPYQVRLAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBW6</accession>
    <name>A0A914IBW6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBW6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9412.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9412.t1"/>
        <property type="gene ID" value="Gr19_v10_g9412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036788678" evidence="2">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9412.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17376" checksum="4AB12908D9122901" modified="2023-02-22" version="1">MKMFALAVFCVTISTCFGDTGGLLCKEGKEELDGITVVKSKASTSHCRPGKYFCAAASCIYLDSGLKATQNVTVWGCVERNEPACGLKNDWPTKMLCDPCFVGEKDIDMANGDYTGVFPTAAEYKLTGRKPPPPTPPTPPTTTEKEPLPPATTKATGKGSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICR6</accession>
    <name>A0A914ICR6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICR6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9638.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9638.t1"/>
        <property type="gene ID" value="Gr19_v10_g9638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9638.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21693" checksum="9827B9692E62E604" modified="2023-02-22" version="1">MARSLDTTTRSTWSSSSPVLPVLLSVYSSTKTRESTIFSTSTAALICPPPPQIFIAPTSVRRVVVFLRLRKLATPNPGTDPPKAGKWPKSGDPKPRTVPNRAQTVQPCPPVLDCAKTVPKSRPISDPGDGQKVNQGRSGRTEFYVTRFFQVCCSFYVTDSTSPQSGTSGAIKAGTASPRSTNRQEVFNNEVKQYDQGKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDZ8</accession>
    <name>A0A914IDZ8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9970.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9970.t1"/>
        <property type="gene ID" value="Gr19_v10_g9970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="566"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9970.t1"/>
        </source>
    </evidence>
    <sequence length="1351" mass="154264" checksum="5A436F64D0028A39" modified="2023-02-22" version="1">MSKRPSNFSIDEILSPPKKPRSGFLINQLLGDIQIGEGQPTTSTRKDAKEYVKKLSNTVEHVPKFRYIKVKTAFSIHDVPTDPEGLLAGIFQYCIDDAVADSRARGIEPTHLGCIISSPQLTGGDIPVPLRQITTDTINTILNLFNKVAQSKQQNNSTLYGEPFNVTITTVDRIGLPTKRQLKGGGRRKLAALHHRVHEQCLIKIRNPDERNYCLFYALQATMTDKTCSWPRWKFYDYLHSRLGQQGRLQQDTIHLMDQVGAPRNLNAYDAETYVPRVVDFWNNSQRQHRFAVFIFGSTGQYKPLYKYVDNNNDYSTPLLLYFNNGHFDGVQKQGGLFGKNYCLECERPYARASTHNKSCRARCILCSRVGPSFPCTPFRGFDKNCAACGKNFRNDDCYQHHLRCGFCKSSKQCKDCGVIWDVPNNTKNGRNGHKCGEKYCERCNNYHKEGQSCYIQPMVVKERKAYRIVAFDFETMQHLPVDSLHPSHRNHAVNFIAAKVACADCISNGKWQQSLNDSSECEVCGPHRTIAFCQQRFMDTPIDKQIVADNPLEEFVDWIVHQLPQKYDTYAYSHFGGRFDMVLTFRELFKRGFNPDMLRRGNKLYEMKVRRQKNRNPNVIFRDSFNLMPCSLAALVPSFGLDVVEKPFFPHLANRPENYGKNIYPSPADYLANGMMPDKRRQFDRWFEQHHQQAFLLDESLAAYCTNDTDILMSALVAFRREFYKVSRRKEGVVAERAASDVHHDGIDVLRESMTIAAASIVPEKGYDNAQNQSLLALRFFHWYGEEHAVQVQTAHSAGGEKRVGIYSVDGWLENEQRAIEVNGCAWHACIKCFPNDNHQLPNGKTAGQVRERDAKRLEFLRSQLSRVDIFWECEIQRMLDRSREMRQKFAEYVDDGPLEIRSAFTGGRTGPMKLFVTRYPIGHPIVHVLNEDVIWTSSADNPYPLALLKVWVVPPRKIDVPVIPVKVGDRLCFPLCMRCASEYPTGGVDKDYRCDHDDIQRGWVSTCTSLELNAALDEGYRVNKVFRVLEYTQSNDRLFRPYITEFMAEKIHASGFIDAIKGNAELEAEFVRECEEQFGITIDAAKMVPNKGKRSLAKLCLNNLWGRFALRNFGLSQTLITDDPVILGEHLDNRSIDVTAIDELDDQHILLSYIQKKEWVEEHDCSNIVISLWTTSAARLLLLKAMQKVVRSPGCTLLYTDTDSLIFAHPIDSCPLQTGPHLGQFADEYPLHEIQEFCSGGAKQYGLCLKRKGADEELEYVLKVRGMTLNYDVLTNQGLRYATFKAQVLHYADTGDYEPIIVTYPNFLRPNIRDGGRVISAPMQKCYRPFIGKGIVGADFKILNFGHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEV0</accession>
    <name>A0A914IEV0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mos1 transposase HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9959.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9959.t1"/>
        <property type="gene ID" value="Gr19_v10_g9959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9959.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17029" checksum="AD931BDCFB242A95" modified="2023-02-22" version="1">MDPQVDKNKHFRHLLLFEFNKGTKASEASQNICAVYGEGATNERTAQRWFHDNARPHTANMTKIALQELDWEVLPHPPYSPDVAPSDYHLFRSLSNALSGVALENAAALQNWLDEFFASKPPIFFKRGIEKLPGRWEEIVNNAGEYFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFL5</accession>
    <name>A0A914IFL5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFL5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9791.t3">
        <property type="protein sequence ID" value="Gr19_v10_g9791.t3"/>
        <property type="gene ID" value="Gr19_v10_g9791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9791.t3"/>
        </source>
    </evidence>
    <sequence length="177" mass="18851" checksum="86538D0AB12E1B57" modified="2023-02-22" version="1">MAEGMESEATPAAPFVNIMAGETEGNVSSAPAPPVEDCFEVVVEFKSADGFTDRSRLRLRISKILDSDRFQPSQAFSTRGDAVVVVVVVSVQSIRSTSTDTSVFSFCAVHYIYEGEASLKWRVASVCIQPFVLYSIRIPVAHGNSVLALCNSTASASSSTTLLFNNNSCGTANIGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFQ6</accession>
    <name>A0A914IFQ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFQ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9481.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9481.t1"/>
        <property type="gene ID" value="Gr19_v10_g9481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9481.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26522" checksum="BEE8645E48C2A727" modified="2023-02-22" version="1">MLELYRSDVDDAAATASAETVQKQCRVDGKFHVDIVQNVGQRHVKWPTNTPPETVKNASKIIAPQSTTGCDAERPASLSRSSESDAQIDELMDQIAQKYRQITGLQTQNCQSQNEAKCRLCFVPIPMPVPVLVPVSTDFILKHFGTNEPIRNRKLDLFHHSFTIRFSHPPTRLTTESLSRPSQFQLTFEKMGGHDHGHPVHRRCRRRRRLTCSSFFSAEAKKDPSINSLDWAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGC2</accession>
    <name>A0A914IGC2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGC2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9624.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9624.t1"/>
        <property type="gene ID" value="Gr19_v10_g9624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9624.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17480" checksum="C7FEEBB1FFF15E86" modified="2023-02-22" version="1">MRKTYPNAAGPAHWGTENCAPAVFGELRTEDCAPWRIAHQQKKEENCALKIAHYHRELRNTDRLQHENKLLKYIQPSGTKSSLLRIQGQLAFVAEHDLSSLKPPNSSRLFTTWLPRLQWGHFPGTVHARPLLLETYLKQLVRGKQKDPLQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTD7</accession>
    <name>A0A914GTD7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10225.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10225.t1"/>
        <property type="gene ID" value="Gr19_v10_g10225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10225.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="34502" checksum="A4262B36E8526515" modified="2023-02-22" version="1">MIYAFQSKARSEKNNSEQFILVLELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVKLFSSGAVELFSSGAVELFSSGAVKLFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFSSGAVELFNSGAVKLFSSGAVELSVRSGAVELFSSGAVEPFMPEALEPLMSKALGPFTSETLEPFLTKALGASFRSEVAEPFMFEAVEIDSSMPKLMAMPYNRSRRHQPSIFLNVSVNYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTZ7</accession>
    <name>A0A914GTZ7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7515 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTZ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10390.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10390.t1"/>
        <property type="gene ID" value="Gr19_v10_g10390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055937">
        <property type="entry name" value="DUF7515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24359">
        <property type="entry name" value="DUF7515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7515" evidence="1">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10390.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22075" checksum="13E341E2A0EDAC74" modified="2023-02-22" version="1">MSGELHKELEDLDLDSAGSGKSQQLELDITEAMIDDFCKIVYRAMIVTAKGRLYATDIALKTFSDLGIDPYKKAIDLGFTSFLAFLHSDYMKKYMEIDSSDGILNYRAIVTPELLKTIGHIKREQRTAFPELNKRSINYAQFRIVYSRDFLLRCAWSPYATLPPKDIREIVMRMGDIVAHFPRRRPFIKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV14</accession>
    <name>A0A914GV14_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GV14"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11598.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11598.t1"/>
        <property type="gene ID" value="Gr19_v10_g11598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11598.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9662" checksum="CF2AE54287914AAD" modified="2023-02-22" version="1">MSIKGQFFCSVELKDNEIILAGEHREQNQGESVHRQFCRRVLIPEGIQKESIKCKLHAGRLCITGMKTTGVGKRSIPIVVKKAVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWB1</accession>
    <name>A0A914GWB1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWB1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11771.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11771.t1"/>
        <property type="gene ID" value="Gr19_v10_g11771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11771.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12121" checksum="A735D72D6D92234C" modified="2023-02-22" version="1">MRLTWMEWNVRAAEKGVGVYAAGREQHKLDTVQRNEVWSENAFPKIRRPRSIIPAPQYFRRLVPKRPFPASPGSSRVRLMKHTSGHRTEAILQQLSKFFEYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWR7</accession>
    <name>A0A914GWR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWR7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11883.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11883.t1"/>
        <property type="gene ID" value="Gr19_v10_g11883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11883.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12753" checksum="CAB50F3680927457" modified="2023-02-22" version="1">METDGPSGEKPSSLQPCRAINAISFCFVTSKFIWEAEKRRKTKGLDRVKDGGERMMPSPQRRISNLHSKMPNSAAAEEVENALGPFWRELDLPWGQNFVPFGTQKARNLKVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXF2</accession>
    <name>A0A914GXF2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXF2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11278.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11278.t1"/>
        <property type="gene ID" value="Gr19_v10_g11278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF29">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="634"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11278.t1"/>
        </source>
    </evidence>
    <sequence length="760" mass="83244" checksum="EE51C24378F03101" modified="2023-02-22" version="1">MAKFPAEGMLLEVIDFNTFTEPISDGAENEKDEQFLGLSEHISCPLCGDFLSDAVTLTGCLHFFCRLCLLRHLSSESASKNCCPKCDVQLGPEKPFFHRDPALQELVFKLVPDIFWRRLARVARSRRRSSRKSLSERHILKRRRLIQLSTALCSPDEKISVQIDYVPLAEVLAANRNLMEPTPSTSSKAVADTKKQLFFRRFFRCAARVRIEQLKRLLELKLAMTDSYGLYFVDGALQNVLEDDYTLENIVHLFNWNRESPLPLLFTLAKLAQEDEDKPPVLEEMPQLEVEGDPAIVSVRKSAEKSLVGEELMDGGGTAAERKESGDGPKRAETSAPALPKGPTTPDSPQLSLGTSQPCLLPSTSSETLPNSSSSLPMNAQTNKKDRRKKKDIGCAAKKQQSPLVAKGEESAKKRKTTPKKEEDSRGIKRKKSKEEMSGGGGREEKKQGDEEATTDGISQPIELRGSDWKESGSDRNSVQQVEGQKEVKSTNELAASTSFDKDGRNESSNGVTEQQTPKMIPKQQPKSKPTKIEGNGKKNTQPKSVQAQKNSSAFSAHQQPVHQQQHPQHLHLPGSPGMPPFPSSPIAFPAAVLQNFLQNGTVADAFGVAFANAFLAQQHQQLNQMIGGMMEKATPQNGSNTKGNNDNISKACGGTSSVKPTREDRPSMVGQAPTSSGTNRCLPMPTSSIDHHNGNIGGSAVQKAKASSHCIYPKGRSDGLVTNVAQHQLKQQQKPQHKLMLNDQASRHAASVLKATLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXP8</accession>
    <name>A0A914GXP8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Netrin</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12320.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12320.t1"/>
        <property type="gene ID" value="Gr19_v10_g12320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902667">
        <property type="term" value="P:regulation of axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000081">
        <property type="entry name" value="Netrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000048">
        <property type="entry name" value="Netrin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF365">
        <property type="entry name" value="NETRIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="12">
        <location>
            <begin position="137"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="10">
        <location>
            <begin position="495"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="11">
        <location>
            <begin position="561"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12320.t1"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119927" checksum="AC422E8E1FAD69C4" modified="2023-02-22" version="1">MSQNPMQALQNIIQSKGPGVVSQRTVKWSHTRDSRSNAKTVLKCPFSNINTDDPKVPCQPPGAGMRHSSCTFALDKQTKPPVWAQLGGVAMPRFPQPFLLLLLLPFLCHFVVRAAYFSQFSSMRQPERDPCYDSSGRPIRCVPDFINAAYGKPVIASSTCGSGGKPSSFCVVSESTGGLLQEKCELCDPSDLRLAHPAALLTDLNNANNLTCWVSEPTSAYPNNVTLTLSLGKKFEITYVSLHFCGRLADSLAIYKSANRGRSWTPMQFYSTECQKVYQRTKEAPINRENEQAARCTDSHILSPLSDRIAFATLEGRPSAMEFEQSPVLQDWVTATDIRVVFNRLSADQAELYGLAESDKLSERIRRDNASVVELSEPDRARERCVIDRMGRYACDCKHATTGLDCEKCRPFHYDRPWARATAEDANACVACNCNLHSRKCRFNAELYRLSGYQSGGVCLNCRHNTAGRNCHYCRFGYFRDQSKPITHRKACKPCLCHPIGSLSRNCNQTSGQCICKPGVDGPTCNRCAKGFKQSLSPDTPCIRPPPLSSLAKSTYPKEDCEKCRATPNRLTHKKFCRRDYALKLQLIGRELVDGWAKFRAQLIDRPIKDQRGTLESREMGDGAELSLWLPNRNLLCKCPRLKVGRKYLLLARHGSFKSDAKSIAKDLGVEFGGKGDKPSLKQSPSAVVFDRQTVVMEWGDEVAERVQRFGHRRHFVEKCRRIRAEEDAAQGKIRRRRGGASACLCPGGGAIVLGLPFGRGEKALPAGKGMKIPFVASRDVNSCWWCTSTQRTKRSLGNISRPPPARLPPHRLPTVLLQHLLPLISLIRRHLPLCATIPTHLLTILNHRQPPRRSHQSLFLLFVISFPLRTLAHYQGASSDYLFGSNSPRYCFSCMSKEFESHWSYLDEIYYRPMNFTDECHAIPTGALIGRTPCAHSVCVTVIEPRMLAGQYLGNNVIRGCFSSVFKYGEAPTDNLVDTSCSTFPMRALLPRHLALKASNRTQVELCRCLGNLCNDYPWTPLINSSDAHQRNAPTTAIAICTMIILMSILFHSFSFSPSVPQFHSLTFKINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXT9</accession>
    <name>A0A914GXT9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MYND-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXT9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1234.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1234.t1"/>
        <property type="gene ID" value="Gr19_v10_g1234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1234.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36152" checksum="1E3890D3250F8373" modified="2023-02-22" version="1">MAFLLQVYCPAGAPHAFHRALYVFVCRKGNCSKINAASNFAVFRCQLPRENAFYSVESALCPAAVGEMSDPFFDPSVFARLCVVCGCRASKRCARCARRWYCGREHQIIDWNCLHKSECVQQPEAFQQNGQNSQMKSDEKAEQRAKHGFAFKEFGIELCSEEDEDNDDDGGNGGERSDDESGSEGEEGGGMEVDGDGKTEEENRRKMVEFEKIAEANGVSARDVDGLEESRRDIAFGRFSAALARYPEQILRYRRAGIPLLATDHSPRPPPTAPSCERIGHVWTKCRLGDSYGVHVQRQLSAGGIRTRVRVQAGLRRPGSGGKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY07</accession>
    <name>A0A914GY07_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g12379.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12379.t1"/>
        <property type="gene ID" value="Gr19_v10_g12379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000594">
        <property type="entry name" value="Transcription factor HIVEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF2">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1265"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1293"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1731"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1866"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="2256"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="2447"/>
            <end position="2475"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="740"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="800"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="940"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1323"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1450"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1546"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1931"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2115"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2316"/>
            <end position="2399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="384"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="633"/>
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        <location>
            <begin position="747"/>
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            <begin position="812"/>
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            <begin position="942"/>
            <end position="952"/>
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            <begin position="1152"/>
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        <location>
            <begin position="1383"/>
            <end position="1402"/>
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        <location>
            <begin position="1450"/>
            <end position="1462"/>
        </location>
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        <location>
            <begin position="1546"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1935"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="2119"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2166"/>
            <end position="2186"/>
        </location>
    </feature>
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        <location>
            <begin position="2193"/>
            <end position="2203"/>
        </location>
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        <location>
            <begin position="2324"/>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="2357"/>
            <end position="2372"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12379.t1"/>
        </source>
    </evidence>
    <sequence length="2486" mass="267319" checksum="83C1DAB70264321F" modified="2023-02-22" version="1">MMPAGAASRKKRWHKAIARCPPPSPEVIPQATSNRPRQRHPLLGAPEQHTSETSTPNGLLGLEQLQQHDLRPLQLQQQFAALMQSQQQQQPTPAPHVQTAPLPPPHLGHQQQPPTQMSAAFLPQQLLEATAQGSNVNASGASVGAVPSASAQLSAATLGFYQQLLALQQAQQQQHGGGGASGGGSAAATPVVATLPQQFNTALHLQNSPGTAVLPQQLASAPSGAPQGGLSVLLGGLLGSNASLLHSLLAGGAGTAAPQTPGATAGGGGNALLTALAAQLLLPQQQQIAQPPANQLTASLLQMLNPATATLYAYQNYLQQQTPAPTPATAGQLQFLAQLLSGGVSAGASGNGGVAIGGGLQTALAALSGGQQQNLLSALAVQQVAQQQQQAAQQQQHAAQQQQQQQQHAAQQQQQQAAQQQQHVAQQQQQQAAQQQQQAAQQQQQAVQQQQPSQQEETRILLEQLIRQQQGRDQQQQIERREREQLQKQQQQMLQQQLGRFNAAVASGSGGCPEAQAPQLEQSPTMTATAVAAFGSAQEQLQQQQQQQQQHHTSVVVEQQLQQQLEQIQQQLNCNIPVEQQSAGSVQQQRQSTPTERLLTSEAVQDRISRLISENEAIVEPNPVLLKRRPYQRQGTSNSMTSQTSETAGPSQRCSPGVRSPGLVCVTPKLHPATTRSFSLHEVGFLRFGGGSLTSGQPINRHVSANPSGGGASTIASLTCNFCHLKFPNEAGLDAHEPRCSKKDVMQQQQTLQKQQSQPQFKLSSQQQHFQQQQQQQHLEHQSTIAALVGGGKGVARDLIINGGGEGGRASVPSSDNGTVVRTQQPPRQLHLLGQSNSDSRLKKRGLAADDACFEGVGGSGSSSELLVDVVRNGVPEPGLAESSKMARIECSTSTTSINLHRQQSIPSGLFEQHVQLSQQRSGSQETQHHLHQDVLGTSAAQQHPQQLQQQRALEHHQQQQQQQQQQQQQQQQQQPVLTMRDAIIFAITYSTDLRSSVKMPYFLTLTPADLEPCADLAAGGAATVHLRGRTRNITSETFVCLNKVRPTASEQRDNCSAYSVGWPPPSTDFAEERLLAQLFLSARTARMRQDSLQGDYTLAASPASTQLRTTHSSFWAQQQLKAHHLQHGHQRSAVEVEETAAIDTLKVEPPSETSGQQPQLQPNTSSKLLSHDKSIIAIQHQQPADGGEDVVKTEVGVDDKENSSSATNALKLNILLRKAPPPLLIKLEKKLGKNKFELNSLTIPRSSHNDEMEVYIRGRGRGRYVCERCGIRCKKPSMLKKHLRSHTNIRPFACSTCNFSFKTKGNLTKHLVSKAHRRKVMDADDNADSVRTSSVEDGERGMCDDMEDEEEDGVGRLVVAEEEEEEEEEKKRRRRERWDRVDDWDDDDDEEADDDEEDEDGSPNGEVPPPPPGTLTYRRFGQENVLVERETHTPPTLWMLMCPERSEWNGNGCSTGTNSGGDVQMESEEEMQPEGGDSAQNGWERAGEKKRSRPANLKLGGWPEPDDAMRERGCHSAPPAALCSPDHSRTRRRRNQLAKVLLLQEQKHRENNMESRAEAAEVQQNRQTSPPPLSNFIPQQPRQQQPPEPQPSLAAQLAVGLLASAPFHHGMGMPIGVAYPYGTVDVINTQQQQQLQQQQSSPKDLSQVHAGHQQQQLMFSPLEHHQQTSAFAPPALASSSQMFDSAVTVAPGLGTTTLLEAANSAFVANDSLLRAQSTLGAFLATDAQQLLCPLCGRKFRKESELSLHRQTHLIEQNAAARQKGSGGAFQCGDCPTIVRSKALLARHSENVHGTKSAALDEGVNAVPCRVPPLQQHLVPSMTSPVDPSGVLVSSSGIPFVSLMLPPSVSTAPGGPALAHSHHRNFLCTDCNLGFRSHGVLAKHLRSKNHVKTLEHSKVLGSIDAGDCEKALNSTKQLLTKMREQLGLDANNDGTAAATTSSSSSFDHRTTAEYPPPNYAMPCPTVVSPTPTRTTASGNSFHDQFAIGAIAEPPQRQDNGTAVASHAKLRISNSITAQKRIAAAESLPHGLKRKNDDATLVDELALFPNSTLRRDVFSSPLPSRAKISREEQISQAESPLHSLAQVAVEVAAAAAAAVALGGGPAAVPSRSSAVCASVVPPPSQSPAQPPAPPPKPGASSAVNVWVPPKLEQLAEPPTGDSRKSSTPDLHNGQSNTDRLGTLLSNRSAEETSESTGTRSESSTPVQRSNAQQPLLAFPPTVTATRCQLCELNFDSPAELAVHFHADHIVMRHGRDFRCSRRNCEKVFPSRDSLRAHIHAHFFGGGATPGHSAGGGDGREEQFQAVLCAASCPASPSMSVRQRHPPAPSAPPPSAQSPGVPEESHTTEQLHNHATMQSHSSPPSVASSCFASGNGAGGGVGMASTPKGTRGVTREQQASDAKVSSVGFPSLAVATLLNCQFCGAQLADVQALQTHWLQQHVAQLARPHICVDCDAGFTTAEALRAHRELQHADETARNAQRISAGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYI0</accession>
    <name>A0A914GYI0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYI0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12360.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12360.t2"/>
        <property type="gene ID" value="Gr19_v10_g12360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12360.t2"/>
        </source>
    </evidence>
    <sequence length="128" mass="14663" checksum="1688AAB187105B85" modified="2023-02-22" version="1">MFNNHINHFMPMPNFSMPPPSRHPPPLSSTRVFFPPISQPQQLLYPRPFAQPHMNPQFFNLSVPPPPIPKLITNLIASNLHTYPNQTRPQINVAHQITTSDRFTKLRHVGREESGFVHGDCLPNSVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYQ7</accession>
    <name>A0A914GYQ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYQ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1236.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1236.t2"/>
        <property type="gene ID" value="Gr19_v10_g1236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1236.t2"/>
        </source>
    </evidence>
    <sequence length="407" mass="44749" checksum="2366A267E87DF5CE" modified="2023-02-22" version="1">MKKSSSRLRTSLKRVPSNSAKFFDGQQKLLGRRTHPLGAKLPISRQIYCWARPPGFVGPIAVRRIGPLFGRRLFRQKKQVQVSSLQDAFDSLAEPIDGLETEARLMAALSQLEHIGVVKSVTKMSTNSATTASTDNEISLLETADVRADDGVVDDRLTISSLSSSLVSSTATTDTEDGGDGVVEGRKRKKKGVDGSSGRAGSVKDVEEMDGEGLLLAEAAASGSDKDNDALCETKTRNQAIARLITFSCILFTVPLTLMYLTYRFLFIGHFHLAHDRAILYAGIVAAATVYLILAVFAWVAYRSRDESELANQMTASAVMEEIIPNLRDPLVKSRMKSLFAYSFLILFVPLGSMFLLKNFLFETLLGYQKRDSMLYSAIAAVVLVHVVLIIWIRTAWDEGKPAEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZB6</accession>
    <name>A0A914GZB6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g12731.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12731.t1"/>
        <property type="gene ID" value="Gr19_v10_g12731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1772"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12731.t1"/>
        </source>
    </evidence>
    <sequence length="1998" mass="220781" checksum="93C3C96B37424C23" modified="2023-02-22" version="1">MEEVVEWLHTPRGDGLPKVLKCVFCPTELVITAFATATEAGQLRLANCDRSGSTASGQLRLSQLPNCVWPTASEPTASEPTASEPTASGQLRLSQLRLSQLRLSQLRLSQLRLSQLRRLSHASEPTASGQLRLSQLRLSQASEPTASEPTASGQLRLSQPSEPTASRSQLRLSQLRLSHASEPTASGQLRLSQLRLSQASEPTAQLRLSQLRLSQLRLSQPSEPTASGQLRLANCVSGQLSEPLRLANCVSGQLRLSQLSGQLRLANCVWPTASEPTAWPTASEPTAEPTASGQLRLSQLRLSQLRLSQLRLANCTQLALFERRRSWRDTVGSDAVGSNAVGPETQLARHSWLRRSWPGAVGSDAVGSDAVGETQLAQTQLAQTQLAQTQLAPRRSWPDAVGSDAVGQTQLAQTQLAPRRSWPDAVGQTQLAQTQLARRSWLRRSWLRRSWPRDAVGQTQLAQDAVGPETQLARRSWPDAVGSDAVGSDAVGSDAVGSDAVGQTQLAQTQLAQTQLAQTQLARRSWLRRSWPRDAVGQTQLAQTQLARRSWLRRSWPDAVGQTQLARRSWLRRSWPRDAVGQTQLAQTQLARRSWLRRSWPDAVGSDAVGQTQLARRSWLRRSWLRRSWRDAVGPDAVGPDAVGSDAVGPETQLARRSWLRRSLARRSWLRRSWPDADAVGQTVGPTQLARRSWLRRSWPRDSWPDAVGQTQLAQTQLARRMATQLAQLAQTQLARRSWPDSRPDAVGQTQLARRQLAQTVGPRDRSCQTGMWLRTQLAQTQLAGRSWLRTQLPRRTQFQTQLAQDAVGPETQLARRSARRSLLRTQLAQTQLAQTQCCRRSWPDAVGSDAVGSDAVLRRSWPDAVWPDAVGSDAVPDAVGSDAVGQTQLARAQLADAVGSRRRLARRSWPRRKFPDAVGSDAVGPRRSWAQTQGQTQLAQTQLAQTQLAQTQCPRRSWPDAVGPDAVGPRTHGQDAVGQTQLAQTQLARRSAQTRWLRRSWADAVGQTQLADAVGPADAVGQTQLAQTQVPETAVGQTQLARRSWPDAVPDAVGSDAVGPDAVGRRSWQTQLVPDAVGAELAQTQLAHAVGQTQLAQTQLAQTQLASRSWLRRSWLRRSWLRRSWPGSWLRRSWPRDAVGQTQLAHAVGQTQLAQTQLARRSWPDSWPDAVGSDAVGPETQLARQLAQTQLARRSWPQTQLARRWLRRMAQTQLARRSWPRRSWPRRRAQTQLAQTQLARRSWLRRSPETQLAQTQLAQTQLARRSSQTQLARRSWPDAVGQTQLLTSWPETLGDELAQTQLARRLAQTHCRRSWPDAVGSDAVADAVGPETQLARRSWLRTQFPETQLARRSWPDAVGSDAVLRTQLLDAVGSDAVGSDAVVRPGWLRRSWLRRSWLKTAVAQTQLASRRSWPGRSWLRRLAQTQFGSTAVAQDAVGQTLGPGRSCSDAVGPETAVGPRQLADAVGSDAVGSDAVDSYSWLRRIVAQTQLAHAGRWLHAVGPRDAVAQTHSGSERSCRDAVGSDAVASRRSGPDAVHQTQLARDAVGSDAVWLPDGWPRRSWPGLQLAQTADWLRQLAQPPVGADAVGPETQLPRSWLRTAVAPETQLARRSWQTQLARRSWQTQLARRSCRRLARRSWPDAVGSDAVGQTQGSDAVGQNAVGQTQLATQLARRSWLRRSWPDAVGQAQLAQTQLAQTQLARRSWPRRSWPRRSWLRRSWPRDAVGQTQLAQTQLARRSWLRRSWPDAVGQTQLARRSWLRRSWPRDAVGQTQLAQDAVGPETQLARRSWPDAVGSDAVGSDAVGSDAVGSDAVGQTQLAQTQLAQTQLAQTQLAARRSWLRRSWLRRSGRQLARRSWRDAVGQTQLAQTQLARRSWLRRSWPDAVGQTQLARRSWLRRSWPRDAVGQTQLAQDAVGPETQLARRSWPDAVGSDAVGSDAVGSDAVGSDAVGSDAVGSDAVGQTQLAQTQLARRSWLRRSWPDAVDPLRSQLARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZE4</accession>
    <name>A0A914GZE4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">40S ribosomal protein S9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZE4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12207.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12207.t1"/>
        <property type="gene ID" value="Gr19_v10_g12207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000004">
        <property type="entry name" value="40s ribosomal protein s9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="12">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12207.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22297" checksum="093E6D76872C9D87" modified="2023-02-22" version="1">MPRVKNVYSKVYDVPRRPFEKERLDQELKLIGEFGLRNKREVWRVKLTLAKIRKAARELLKLEDKDPKRLFEGNALLRRLVRIGVLEEDKMKLDHVLGLRVENFMERRLQTQVFKLGLAKSIHQARVFIRQKHIRVRRQVVNIPSFIVRLDSQKHIDLSTKSPYAGGRPGRVKRKNAKKGAGGGGSAGEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZT1</accession>
    <name>A0A914GZT1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZT1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12321.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12321.t1"/>
        <property type="gene ID" value="Gr19_v10_g12321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="296"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12321.t1"/>
        </source>
    </evidence>
    <sequence length="685" mass="77942" checksum="661722654510EDDC" modified="2023-02-22" version="1">MGISLDRWHKRRKTGGKRNPIHKKRKYEMGRPAANTKIGAKRIHLVRCRGGNIKHRGLRLDNGNFAWASEGCTRKTRIIDTMYNASNNELVRTKTLVKGMIVAIDAIPFRQWYEAHYALPLARKKGQKLTEEEEARIGGAQKRSKSTLKKYTDRQKTAGVELHLLEQFQAGRILACISSRPGQSGRCDGYILEGKELEFYNKKLKAKKAKVGSVEKTLLDLLKAFSDANELCCVVLCSWAAMPRPSSASSLFRSFLIRFQLKTNKARKWRLSLPELTMRIPIITRLSVTMSLAICGNVFLVFVIRRGNAVARQRASPVQLLLLHTCTADLLFALLSLGTQIVILTTYPYFYGSDLVCRLVRYVQALPMYASPFLLVAISIDRYQVGFVPIKQKSFLFWAICRPLVHYRSDRFRRPNWLGLVAWLMALFCSVPQLFFWRKDSLRHSSPSANDGPSSPTTTPKEECHTIYNSVTLDPWLCVYVVWFSTVTWLLPSVLSAFFYFRVCSAVWKSRFWSCSDEEIVLDKGTGTTMTTSVPFNQHKLSVPSCQLTRDYVEGLRKSSAGFRNQMSEFDRKRIQTVRLTLTIVPFSLFPFGLPFCAINVIQAFWGLNLLSQEVILCVVIFGNLNACVNPWIYILWNFRQTRRALFSLIRKENELITTSTSATRQTSIGLRMTVNPASGGGAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0N2</accession>
    <name>A0A914H0N2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0N2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13088.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13088.t1"/>
        <property type="gene ID" value="Gr19_v10_g13088"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g13090.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13090.t1"/>
        <property type="gene ID" value="Gr19_v10_g13090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13088.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13090.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13428" checksum="C8053ED3EC1E7EA0" modified="2023-02-22" version="1">MTSVTSQRHNPGQVASQRHNSGQVASQRHNSGQVASRHNPRTSCGATTLPQDKSCRNDITPDNSAAESQRHNPGQVASQRHNPGQVASQRHNPGQVALQRHNPGQVASHRHNPGQASLQRHNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1D3</accession>
    <name>A0A914H1D3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1D3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12750.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12750.t1"/>
        <property type="gene ID" value="Gr19_v10_g12750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12750.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41105" checksum="B480BEAAFC566371" modified="2023-02-22" version="1">MSDNQECGETIEGNFHLCRPFVRIFHPFATTFCYEVFEFCGPFELGLKVELLSDQFDRLVDAHFKSKEWTYLLVNERLKLKEWSLGRLEIRRAINGNGAEIVMRIGNDFKRRLPIPQNPLPVKVIGFECLLIRYIDQSVVEFLQRIGRLFDSRGTNLCFGTSAFGSRSLEIIWKNVWPLFKDNICGFELLPSDLDCLRQFSSTVLGDCPKLRVIECLNLFPEFPADDSAGASSAQAMTKWLHTPRGDGIPKVLKCQRYSSWPEMEGLKLAFFNSIEPVNFIIYFWTFSSAAIVPFKLNNNLTGERMELRRFDGGIWLLIRCSFKRDKDKWAEYEKVANYCRGNRVIIDFKELYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1J0</accession>
    <name>A0A914H1J0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1J0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12376.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12376.t1"/>
        <property type="gene ID" value="Gr19_v10_g12376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF201">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="134"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12376.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38822" checksum="67110345D73AAF2B" modified="2023-02-22" version="1">MFGCSPPPSSSSSSASSVASFSPPNYRHVWNLLLSLPVLATLRAVAKSMPYARQGFFCNDNEIRYPNVSDTMPSNLLDLIFAIVSLLVVVVSECTLVRHLCRRRGRRLRLPESSAGSAALLLHPVLVNCCFFLASLYASLAATSTICELGKRTCSRLRPNFLAVYIADYECTNSMFDQNEFFSFPSGHSSSVCNFAVFIIHYLQKRFKLAPSVRSFVQFFVALFAYFVCLSRVRDHKHRLTDVAGGALIGAAVGVFFLRNVLHNFRPNRYSVVDTNAIAPGDWPDIEGPPSPSATETLLSTKLSVPRTIVVPQRQPLQQRPNDGERPNDYGSLREYVVGNGKERDDPGANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H267</accession>
    <name>A0A914H267_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H267"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13312.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13312.t1"/>
        <property type="gene ID" value="Gr19_v10_g13312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13312.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17181" checksum="D29E350F983D9D21" modified="2023-02-22" version="1">MGRLTPSPNLCKVCGDKTFGRHYGAWVCDGCSCFFKRSIRRNAKYKCVAGNGMCLVNKCRRNWCQACRLEKCIAEANMIKESVQKEKGPRKKKPTRREEGGPGRGAIAVPHTMANSTNSASVPVQSAFYPPITQFHRLALLHRFWQQLMSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2B6</accession>
    <name>A0A914H2B6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2B6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13350.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13350.t2"/>
        <property type="gene ID" value="Gr19_v10_g13350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056801">
        <property type="entry name" value="SBSPON_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25031">
        <property type="entry name" value="SBSPON_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037043204" evidence="2">
        <location>
            <begin position="19"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="3">
        <location>
            <begin position="228"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13350.t2"/>
        </source>
    </evidence>
    <sequence length="510" mass="58476" checksum="57ADADDE3E53000B" modified="2023-02-22" version="1">MLLASLFLLLLKLLLVYCSPSFRQLHLPLALLQVFFLLPKRVILANDERHSHPQQYHHQPALPVPQLGCFRFGQPLCCEARNMSCKSMQDSGRSILSFVPRDDRVREVRFGNNCIGKVVLPNFVSLNERGVQILHQLGQREHFGLYSGRRRKNVATFTDFDVPEEEETVIQFGSEAQMRERMDDDQSEEDEKHSPIVRYSLLSRYLPLRIVKRRIRVPNKVSQSAQPEEWTASEPWRMNILMEANMDCFCDQFCTDYGDCCANYAQACPAIDCEVSEWSEWTECSADDGFCGIGTRGRGRAVVRERMHAGRNPAGINAFLQCLTSPPWLCCLTTSTTAPEGRGGSTKTTPSIQQRRHGAKKEANVQYCVHYRIVWLNQECTDEKRWKSKLRPGNVICAECQPEAQFHRSVSRCASDLEDGHSGFWKLIGPKYCYGIWHRLYSSGSSPPSSDCKCDKRFPQLSPFLLFVPLLFQRLFHQLAQQWTEAKAMAMDGRKVRIFCWPIILHSPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3H9</accession>
    <name>A0A914H3H9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membralin</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3H9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13506.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13506.t1"/>
        <property type="gene ID" value="Gr19_v10_g13506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019144">
        <property type="entry name" value="Membralin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF4">
        <property type="entry name" value="MEMBRALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13506.t1"/>
        </source>
    </evidence>
    <sequence length="653" mass="76061" checksum="6E971CD448F673A7" modified="2023-02-22" version="1">MATQNFSELRPNGGEVAERQQQAMDLPNNPNQFVAANPRFGNFRDRLFQAMLVRLSLPYHQNVPRTLRRFFEFITLINASVLLAVLIYTHVLLNSYPARCLDSIHDDWPRKGIIRMEVIQNLAEYREMQSRNEKASVRSHCRLDLADILRNGELPANLRTQLNDGPSVLSMKVINGSRNNGNSMQQGRVRFGRPLPILFDLFHWLVDQFNQQDWDFAETVDVGETGQSLEERADRAQQQEDYAEVEDSHQGQKFKRFDHTQTAPVYHHLVEFSLHYGLLKLSMEMRHELDVEVLLIQLDPEKDECFRDWREQFLMRYLIGMDELILSSVKHLLENETERGYLRDLIGGELYHFVSVGPSSSSTYLMAMIVMLVFTLAISMLLRFSHDQMFVFIIDLFQMFEQNQPMMFPVAPLLTVILALIGMEAIMSEIFNDTTTAFYVILLVWMADQYDAIFCRSPIGRRHWLRFFYLYHFAFYAYHYRYNGLYGGLALLTSAVFTFHSMIYFYHQYELPYIIYQEQLIELANRLPNEVVQGFEAIAHGGRQPPQQQADQVENDELANRSWRTVLGGLRQRMLGMSPIAALMRRIRTRHSTAGERQQNDGEHQNSSRPERRASERVAEQILDETLREIVGTSEDEQGQPSGQNTERNMMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3T8</accession>
    <name>A0A914H3T8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3T8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13.t1"/>
        <property type="gene ID" value="Gr19_v10_g13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="51833" checksum="310323DE6C7DA590" modified="2023-02-22" version="1">MSSANGLSNQFNHLLSSTLNAGFNPTNSSTNMPIQNLSTMSVPPPNVPSLLQLQLFDLLVKAQQMITAKGQVQQQQQQHYANIQQKCSPTTFESLRPSPNNNGMDHKNFWSTTSSDRSSPNCADQNGDNSSRRRRRAVANLDNTLDGLVAKRAEQMPMKRRYQSETEAIELPDDELETKRMEADPDVCTRMCSVCGYQGKWVSEMIRHKRVHTSDRPFKCKYCNRTSKWKADLIRHVAKTHGIRVVSKYSRSKAFELGKPGQQPKLMLSDDERDDNDVIVVVDSGTTAEGNDGSGTFSSANSESGGGNLVLDENNNNRRASSRSSTGSGTTGSSSNQRREKNSDSLNSMARKAQRLSTIVCRSQQVQHVSDTAHMSPNPSTPVPAKANAIVGRTLVAQPAAAAVPFLTGQQLQQFVGTTAAGADLPAGVHQPELPKVSASRPSSSLTLLQLLSNFPQMFNQFQNGGQHSSCGHMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4A7</accession>
    <name>A0A914H4A7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H4A7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13515.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13515.t2"/>
        <property type="gene ID" value="Gr19_v10_g13515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13515.t2"/>
        </source>
    </evidence>
    <sequence length="175" mass="19933" checksum="A3831CDD930C4CB7" modified="2023-02-22" version="1">MYSRIGPWGFSTKLSSAGLIYAHYGKAVIGSILGLPAEDADVGKLYEQIYKKFVEAIDAIDNGVNQFDGLPRFGDRKSRSGSIQAVSSFRYQLSSREFSNIADDAIDVEDNEEEDFEFKKRFGHVSTLHWLPEHKLGPFNCLDKTHQRYAYFCTPKFCLVDSTLLLLKQKNRSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4P3</accession>
    <name>A0A914H4P3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4P3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13958.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13958.t1"/>
        <property type="gene ID" value="Gr19_v10_g13958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="373"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13958.t1"/>
        </source>
    </evidence>
    <sequence length="573" mass="65526" checksum="96BFB24EEEA59450" modified="2023-02-22" version="1">MSISTESVNGDITADQEHLWPTFANLDPSEELRRLRARIVQLEHQQMINSSISSSGFDLVAQNGNDAVYTLHGQNDEIELNNDKEFTADQEEAEGQTKLDQLEKQTANAEQQKVNQKALSTAIDQGINQLKEELSAKMEQYQKEQQLNIDALTEAQKRNVDHYSRMQTTINDLEHKQKNDQEELLRKMDESQAMVVAKLEDQKLLNVNKFAELEKYQNKQQQNINAFTEAQKGNVEIDGKIGKLERSDAILNSWRCDPYRIVGLIVLFILFIFAIRGLDEQKENRLKMNEQWNEIRAINESLNLVQVMLVAELDEQKLSNANKFAELGQQNALQEKVVKMEEYQKQQQQNIDASTHLFVKMKEQQNEMRAMNNSLNSVQAMVIAELGTGLIPQQNRWDSAECHWDLTLSEPEQLIVQFTGQIKRGWFSVLAERPIPKGNSGIFYYEVKILEEERGIFIGLGIKEMRMYNCIGYYKGTYAYESSGICWGHEVAGCSHWNGRPYIEGKPKFGVGDVVGCGVNLATRQIFYTKNGQRLDPANLFVSFAADLYPSVTLYPSGDKIEANFGPNFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H582</accession>
    <name>A0A914H582_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H582"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13940.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13940.t1"/>
        <property type="gene ID" value="Gr19_v10_g13940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13940.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="48914" checksum="0F844D4DA9FC6D56" modified="2023-02-22" version="1">MEEALTSFTAAGFQRALNYIGIGANEVKAVDGDGRTDSCGQQRFGGVCSFRGGQRWSAVSEQSIAVLILSVSVGLSSNLAFSLTFPPPPPSPPTHKVNATLRPSIPSPTTSKVHPVQNQMSFIDAPPPSYDQIDSHPPAGGDSIGYDLSEKVAEQSSVIRVQELEIGKLRRDLGRMKEQMERFEQRDEETQPPPGKATPIPPKLEQTLVQVVSEEVEERRRRRRSKKWDIIGGFVCFVALMAVLGLGIYIVLSKPPNSLINSVISDQQTIQNGGNSSKRATATTFSTTTTETATIVRQFRIIGKVDGDNLCWARAVLSSDQSHPRHCNVIRRSLGDPRLFCTFSLGNSAALSFGGTKGRFVLPMVPKGKAVILLKDQQRWRSSRKAFGTVHTHTLSLEEAVQRRQKASTRWGRTENGDSATAVLGTPVGKKSLTMNACHANELTDHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5J2</accession>
    <name>A0A914H5J2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="13">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54232"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:76979"/>
            <dbReference type="ChEBI" id="CHEBI:78228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:54233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74963"/>
            <dbReference type="ChEBI" id="CHEBI:82949"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:54333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:54245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:32940"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914H5J2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1387.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1387.t1"/>
        <property type="gene ID" value="Gr19_v10_g1387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000002">
        <property type="entry name" value="Choline/ethanolamine phosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF41">
        <property type="entry name" value="CHOLINE_ETHANOLAMINEPHOSPHOTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
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            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="594" mass="66690" checksum="AC679A98742414A6" modified="2023-02-22" version="1">MARTRGGGGGLKSQRDKQKKEQQQHGSSSNNSLVETDQQQRKMNSNNNNISSLSDNDGGNVQRNSFSESLATSLHNNQRQQRQQRSTTPRELKGHGTKTTTKSNVFKRARMHLFEFVNWYIENDCQLNTAQIVRLGAHVYSSVDSSLLDHLCMSRFWSWIVQLYPIWLAPNLITLIGLIINLITVLVLSNFCYSAKENAPSWAYALAALGLFLYQTLDATDGKQARRTQTSSPLGELFDHGCDSMTQVFVTLNICYAMQLGSHRHLVFVTMLVSLGLFYTAHWSTYCTGQLRFSKFDVTEAQMTVIGILIATSLFGPGVWGIQIFGFQLNILCMFISLLCSVWRFAGYLKVILNDGVGKNGSTVAGTSVIYPLFPLLAVGVPFLMIYYKTYSGVYDQNITIFCLCFGAVAAKATNRLIIAHMSKSELELWDWIYLSPFVMILNQYYDYLLDEYILLLAATAYAYASLIIFCIFICKQFCAFLGISCFRIDVQRHRRIPSAEVSPKGPLSAPPTASSVSLIVFHWHFGKPKPTFASHNVANSSQTSSFLTSEKVIPSPQHTTASSSEKQPEEERDEAIDICSNQQHYLTISFRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6R9</accession>
    <name>A0A914H6R9_GLORO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6R9"/>
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    </dbReference>
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        </source>
    </evidence>
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            <dbReference type="WBParaSite" id="Gr19_v10_g1471.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8390" checksum="EFB568E2ADE60D9D" modified="2023-02-22" version="1">MEEAVKSVKNSAIILMANLNKDADAQRNIKTFAENFLQNELFKEKMQKFLSDFKFNSFSDALNIATKVPYILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6U3</accession>
    <name>A0A914H6U3_GLORO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="Gr19_v10_g14232"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
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        </source>
    </evidence>
    <sequence length="984" mass="113149" checksum="883A12285A814236" modified="2023-02-22" version="1">MQHRTCAFWSDLLRSRCKSDQTKNVTDNNTDSDHESLKMIAETVLMECIDQRNVSVGCLAAEFLFRNGDKHFDAKTATNCPITMSGYLNSLVVKNCNDGTNNNNNNANALCHFLAHILLQFDCRIPLHSLGVLVKIVKAHLHDASVVEQTNTGRLIQLWHQCFYLERGGPNELNKLIAKNMITILQRVGPPPNELFKHLLFRVPHFIRHKYLLMQYLLSDSPLDQLDEPVLLTFFDQLASCLEGRGCQADLADAFHALAIRFLELGKSELLMQLISKTLHSNNGPTRENAIRLWLPKLNTSQQLRQMFVALLDSFRVELHNNLSTIKEEENEASVSAFDQSPPYWDYGSFVDPCVHWTQQQINLWSFVQLFYWTAKNRVPLLHAQMSEDVEIVVNALIYGHKDEIKQIAADSLLLLLQRPKQHLAKTQAEHIIRRFASHFEHLMRAENAKLCNSVNSLIVNLLKFYDQEDNAVILLKCRFQQLLNNCTKNIQSPIFFCPITGNLLQLIERMDDDYCSTNEELQLDVQNFLLKALVYKNDSTVRQRSALIASRIANGCSQFRSELITLFNESAPNLKYGIAHLYRLILCLRVDERDLNLHFVGDEDGLTILFKRIKFEQQNQLANENDAIAHFLSHCVDVNEKLLQIGGSGRPAQCVTVSELHLLFEKCSVEDGENDDDLLFWSDLQRRQLAIYSNGIIQSCSALRWILTKFTNQIDAFAIQKGLRSIWTVLLRSHHKGVLEHCAVRDKINEKTLSILFYGGGQCRNIAFAKILVPIFASLCAKRRTDFVKKLIFAFNLPQNSIMCAFDQTKLQLHQLFLLKQLVSTTKFDLRELRTEIFQFIIQMTRLAMNKGQTERWRLFSMAGNAFAALLNSIFRHFPDIVPLHNFYVVERCFCDNLLNFLRNIRIDLTQKRRSEPSIALLLVPLQRLFVVDDPFETYAPANGFVAEVCLELNLLMRLEPSVLLRRQMEQVITNFKGHPQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8B9</accession>
    <name>A0A914H8B9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914H8B9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14169.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14169.t1"/>
        <property type="gene ID" value="Gr19_v10_g14169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
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        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="236"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048871"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14169.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58516" checksum="C60017A6847479C3" modified="2023-02-22" version="1">MPNVICVENIFTTNVTGANETANSAAKVVFDEENVQTLVEDAIDYAHNVFLIVRTQERKDISDYAQIVPFTLFPSPYPREMFKEAIDVAKAMSLLYFRVSRDFEFLKMVYKDVLELDESIRNYMNICEEVLNEGIKQPFSIYLQRADYYVHVREDGAEKKYELKQIEVNGGPVGGANGIPPRITKLHERTLSKAGIPNLPEDVLPKNPNAKAGAAEAVVHAWRLYKQKFTHPDPIIVFLVLKDNSYWHFLKRYDEYEIEQIAKNKIKVVYVTWPECIRDLTMDDDFTLRLKGQAVAVFYINYSITGVIFSAKSIETYKIIERSTAIKSLSLFYELSVSKKVQQILSLPGMVERFFPDPKEAPMVDAIRKTFARMWGLEDDDLETREIVADAIAHPERYVMKPNREGGGKNFWDQEIADNLRTLAPKERAAYILMEKLNPLTVKNYLVWPFKEVVYDDVVVELGVYTFMVGNMQDGTMSHYAQPGHLARTKLATSNEGGISSGTGTFDSVYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8I7</accession>
    <name>A0A914H8I7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8I7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15026.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15026.t1"/>
        <property type="gene ID" value="Gr19_v10_g15026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15026.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15796" checksum="2C2CEE36AC32EAFC" modified="2023-02-22" version="1">MKAELKRAGFKNSYKNEIDETVAKKLGLSFTTIYNWKRELGQSTPNHKYTHSEQKKLMERYYEIKDQNPKTLATLCQKPTQKHYIPVFEKPKAGKKYKDVPEKDSVQRPLRWLLVLLARLPKLVNNGMVAVLHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9G4</accession>
    <name>A0A914H9G4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9G4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15012.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15012.t1"/>
        <property type="gene ID" value="Gr19_v10_g15012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15012.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22269" checksum="4C917972CC55BFA1" modified="2023-02-22" version="1">MFGEGDSSSSESECAGYGAMRRKPKFRPRIDWTSSLSRADFHERFRLYPRQCEELLNLIGEQISPVAMTNHALNSKQRLLVCLRFLATNSAYFSVGDAEHVSKPTVTAVWKRELGQSSPNEYAHSKQNELMKRYYKIKGKNPKIRDEDNAKNLKIGRVTLYRWKKQFKLEQLDPNSVDGHSVEENAAANVQEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9Z2</accession>
    <name>A0A914H9Z2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione synthetase</fullName>
            <ecNumber evidence="4">6.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914H9Z2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15414.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15414.t1"/>
        <property type="gene ID" value="Gr19_v10_g15414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037962146" description="Glutathione synthetase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="16">
        <location>
            <begin position="354"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15414.t1"/>
        </source>
    </evidence>
    <sequence length="644" mass="74623" checksum="C550D03188266574" modified="2023-02-22" version="1">MHYFISTISFIFLFYVPTATASVDKNDDTFLAFVKGDPNQNNEVLIQMYEARLGLMYLMRENWKCDKIRKEIKKEEKEYEECEKLRKYLDILYEYLFQVYTGPETAADQIVKPMFKHNDKNVSGKEVLISSQHDELNSSTNYTDILTTFLQRDDAKTQLLIKEAKDWAQNIELIIREPKFDANLSRWFYQTVVAPFTLFPSPFPRKFFEQAANVQTALNLLYFRIMRDYPFLKEVYQKLIKNEQPLSSALQIMEEIHLEGIKQPLTVLFQRADYMLCESNYEGNEKPSFELKQIEVNGSAIGGLGYSTRTSKLHRQILSKTGLNLSNSVENNTSALTVEAIYQAWQKFGDPKAIIIFIFDEAFFAYYERIGLYFELADKFEGKTEIIALNLKQCAEFLKLDPHDFTLRYDDKIVAVVFNQDNMLSTDPKKMESRRTIERSTAIKAPSLAAALAHTKKVQQVLAKPGMVERFFPNPEEAPLIEAIRKTYANLWTIEEDDNNEYPQIIEEVKKDPHKFVLKKIEYAQYQNRNLARIYFEQEILKSMTNFTPIERSAYILMEKLQPTIVKNHIVKTMFDENMNVPPSIFEDVTPELGIFGTLLGNIVDGKVLHNVQLGHQMKTKLASENEGGIARGKSAYDSAYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC74</accession>
    <name>A0A914HC74_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC74"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15263.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15263.t1"/>
        <property type="gene ID" value="Gr19_v10_g15263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15263.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7765" checksum="D3BE1E65D2A90779" modified="2023-02-22" version="1">MTFRSWKKEFGLPFKSKYSDREKLENHPTFADNDTSEHPMASSDDTLWAWNLAKKKRTEVEQSGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCK7</accession>
    <name>A0A914HCK7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis regulatory protein homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCK7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15865.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15865.t1"/>
        <property type="gene ID" value="Gr19_v10_g15865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055315">
        <property type="entry name" value="Cramped-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677">
        <property type="entry name" value="CRAMPED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677:SF1">
        <property type="entry name" value="PROTEIN CRAMPED-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15865.t1"/>
        </source>
    </evidence>
    <sequence length="706" mass="81113" checksum="AF73E4798025FF84" modified="2023-02-22" version="1">MSVVMETPHIDVGNLLLIDGEAQVDDLATINSEQICELTRKNAQRLFDEIWKLPRKIVQDATCSQLPECTYGLPREKPIPKPKEPTKWEKFARTKGITKKKGKKVWDKPSQEWKPTYGYRSANNQSKDWLIEIPDHKDPYKDYFAEKREGKRERVNKQELMRLKNIARLAAENASTGFLVSRRRLAFRPPHLATKKSNVAAFVSAEKSDTNGATSAQLPLNALKLYGKDFDAISKFMFKKKFNKDKDQDADWENIPRDAKELFVLLNGFEWRKRLKGLSFEEKKFRQLVMEGHTSFRPRRKKFIVNLKTPYCPALLKYFPYDKRNYEIPQHLSVKLTPLRNQDREFVVACEQNPFLIVQINVNDKILSLFDLLKRKWSLAARKMPNVQMSNEHTSSMDVGIRLFVGESNQIIHNVLVGNEGNSPLLSLTKLKKNFSPIEGAEIGKFVGSGRQSNEIKLNASSVKEVFEINEDKIRAGLSVQEVGNASMLQLFYMLGMKKELSFNYLFFDAQPDINNIFEMPKTTTTTTGVVERENAQFVEQLKTHCNIMQQKKPKRQIKLVPDNQRKFMRISAPVPTQQRVLKTNVAAQHFYMPENSVFGRTVHPHPQMSDVVLDTATDFSVFQNFSESRQTAQFNARFVPIAASSSATFQPIVLGNSPNKGLPEDVRTAYEQMLKENSIDYCRQFEQLANLHNDGSPIKTFDEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDI1</accession>
    <name>A0A914HDI1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16023.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16023.t2"/>
        <property type="gene ID" value="Gr19_v10_g16023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000770">
        <property type="entry name" value="SRSF protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1088"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="479"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="558"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="653"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="782"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="877"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16023.t2"/>
        </source>
    </evidence>
    <sequence length="1455" mass="168183" checksum="13A8FC0E7BEA29D4" modified="2023-02-22" version="1">MGSRRSLDQLGSSADAPKAMFVLSIGKWFGHFAHRRREEAANREKKVLGEMGPRAVVTKKVIDARLGEEGHEHGDGDEHQEEEEVTEDVGERLIEEAEQKLHEEESDHFSDKLENCGEVGDEKGALLALGDNVSSDFLAKALDSEDELFLEASAFAEFTISEDGSILEGFSGWEADDTDAEYETSMEEILLLKHTPKVDKGADDKSLQEPTPPSKIASVCSSTGGEGGGPPTNWTGAGVRTMLGGAVEALIATILKTSKAEVMRVKLGEWVDRQCRTEELWVGENGPEEEDTTKEKQMEEKEEDEEEEEWEYEEEEEKEETTKEVQMGEKEEDEGDDEWEYEEDEEKEETTREKQMGEEEEEEWEYEDEEEEEEEAQEELDEETNKFGDPQRLMKEGQPQKSNQYLAVYMASTCIKYEKGHCQKEQRRNSQGDDDELSIYSDALEGPLDGPVQLKEANKHAEGDMQVMNRKKEEEEEEAWKKKVEEEKGREEEEKERKTKLEEEKGREEEEEKKTKETEEEEERKKKVEEEKEREEEEERKKKVEEEKIREEVEEEEERKKKVEEEKGREEEEKERKTKLEEEKGREEEEEKKTKETEEEEERKKKVEEEKEREEEEERKKKVEEEKIREEVEEEEERKKKVEEEKEREEEEERKKKMEEEKISEEVEKKRKLEEIRKQREDEVEKGRVEEGKRKEEEDRKRSEEEEQKTIIEVKLVEEQLVNSETSDDEFEEEEEVELEEYTDEEELCSEMSQVEREIERMRRESVAGTEERQLKTYPTMNHRETSPEREGEQDDIERMEKSDAVGRAEKERTPVGVEEYSSGRSTAGAGGDGFMVGEENDRDRTETPKPPKPPKQEQQQPQQKYARTNEFQWPSEARRAAPPGKERESAQTPVVLPEQKQTDQLPCSSFSAIAGGDDQKRNIFSQPVAVAPNLEVNRLTRDKIELFEQLPSPAQSVVQTFQQYNASGRNIRLRHEPPWNGLSSSRRSLFTDHPLISKYCPEATTTSKFGAEKRSWQRTEKVEEATKKPRNLLEMETSIASGGSNFLRDPFSHIVLSDVNGDHEDPREYRRGGYHPVRIGEIFNRRYLVLRKLGWGQFSTVWMCSDAATTTESERYVALKIVKSHRDFSDAAMDEIKLLKAVRESDPTDEGRHRVVQLLDTFKIIGVNGTHICMIFDVSGCNLLKLIIESNYEGLSMGLVKRITRQVLQGLAYLHVKCRIIHTDIKPEVSPPPPFIVPPLNCPFCPFPNVLVALDPREVARMVAESARAPAGRVPFSPTNKESPFGWIGRELNVKIADLGNACWTFHHYTENIQTRQYRALEVLLGADYGPPADIWSVACMAFELATGDYLFEPHSHTLWSRDEDHLALISEMLGPIPADIFKRGNYWRDFFHRSGRLLRIPRLHPSALVDVLSGKYNWSLPEANAFAAFLLPLLAFDPDVRLTAAQAHQNLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDM3</accession>
    <name>A0A914HDM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16052.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16052.t1"/>
        <property type="gene ID" value="Gr19_v10_g16052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036837905" evidence="1">
        <location>
            <begin position="26"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16052.t1"/>
        </source>
    </evidence>
    <sequence length="462" mass="51605" checksum="0CDDB0084418B243" modified="2023-02-22" version="1">MLIIPLPFSFVLNLLLILLLRPTLQLQSLSDSANSLVFVTLSSDGNEANINLLVKQLEDGEDLLLSVPSSGQSLKMPLFYNVSARPSNNGSAAAPSPSSNDTQNVHLSVYTARVNLKEQKSNGSIEYALNAGGGGRNELRKALKWLKAEKVGDESPLRVCVFGDYRADVMYTRELNLSNYVVSSGCDLNLFVGKISWEQRNCPNCSAVWPNSSPSLLREDVGLSFSPFSMLHDHARSGQASIFASVPSIFGAIGHNLNETTFFDCIEVKGVAFIQTTVEVSTVARLGGNHQTEQFKYVERYFRETMLNELECKLQELHRRLQRPWIIVYLTHPSLIDEKRTDVLSLKDNDRFFEILNRYKIDLLLSCGVEGMAKILAERRQNNPKEQLPPYLNTTMATCLNARGCQYLVLEVKSNELNYWHKNGEGVPLKEGTFQKSTKSADACISDEILSINGRNVTKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEH9</accession>
    <name>A0A914HEH9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEH9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15879.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15879.t1"/>
        <property type="gene ID" value="Gr19_v10_g15879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15879.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9313" checksum="14BA91BE01CEA374" modified="2023-02-22" version="1">MQILRDLSSFVLKSDLATLGVGFVAGAGFELFKINFSLLNVSFYKVFNERQLRRELSEFEETLVNRNKILRSRLEGLQNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFB1</accession>
    <name>A0A914HFB1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFB1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16451.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16451.t1"/>
        <property type="gene ID" value="Gr19_v10_g16451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16451.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37419" checksum="CDB8FBD71D825576" modified="2023-02-22" version="1">MSDNSEQQQQMQEISICADVWLKVFAFLSPLELGLKMALINDRFDALVDMHFKSRKWSLSWLHIHRAIDGHGAQIVNLSGDQLPIPQGPLPGQVIGFEGIRISYVDQIVIEFLERIRRLFDSAETNVYITTSDNQNRSWEIILEKIWPLVNDNICGFLLVASPQLAHLRQFSPTILRDCAKLRSIVASCQLFPEFPAEDNAGASSRQAVTKWLLTSRGDGLPKMITFIFIPQGISALKEAFVNAPEPTNFILNNMRERLTLRHLNGDNWLLVRCPIGREEDKWAKWEEEAIGWEWRRQWNRISIELEDSDIGDKTGDAKAGPEPTDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFF6</accession>
    <name>A0A914HFF6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16482.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16482.t1"/>
        <property type="gene ID" value="Gr19_v10_g16482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16482.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8271" checksum="33738C8769848873" modified="2023-02-22" version="1">MWRHFPDDLQRVGEGTDFVWGCSARLRSCALLWLAPLNASGARLRRGDLSTGSSSTSTGGTLAGVPPIALASVAKNDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGE5</accession>
    <name>A0A914HGE5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGE5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17262.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17262.t1"/>
        <property type="gene ID" value="Gr19_v10_g17262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF385">
        <property type="entry name" value="CUTICLE COLLAGEN BLI-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17262.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="31900" checksum="1087D56C861F5F37" modified="2023-02-22" version="1">MIVSSAEMSTEKQCHRKGTLRPVAFAAVVFSTVAISSCLLTFPLVFHYVQTLQAAVQGEVEYCKSRSRDMWREMVDVEMATLESEDELGGARKNADEEVLVMEMLGMAHRQRRQAEDETLCCTCQQGPPGPDGAPGEPGKDGAPGEGPGPPGPPGIDAELHDRVLPVPPQCPCQAPPGPPGPPGPPGNDGLPGGPGRNGEDGATGPIGPPGPAGPPGQPGPPGQRGPPGEPGQLIPGEKPPPGPPGQPGRPGPPGPPGKPGQVGKDGENGPPGPPGEPGQRGPPGPNGPPGVPGQVGQAGAGGSCEHCPTPRLAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGX0</accession>
    <name>A0A914HGX0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemimethylated DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGX0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16510.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16510.t1"/>
        <property type="gene ID" value="Gr19_v10_g16510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053189">
        <property type="entry name" value="Clp_protease_adapter_ClpF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48439">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48439:SF1">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036757141" evidence="2">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Hemimethylated DNA-binding" evidence="3">
        <location>
            <begin position="109"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16510.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25244" checksum="65AA95E31CCB8BCC" modified="2023-02-22" version="1">MVEISPTLLFAGILFSVPLQFYLSARSTSDAQFYLHEFVQQLREVYGRYFSPIFGRSSVDENVDEEEIGQKTLRESGEDTIDESNLREKGESRDVFGASSEPRHPRPPHIKYRVGQVVKHRIHNYRGVIIAWDEKAKAPDWWIKKVHGAEPIDEPNYTILIDTRDRLIPQIAYVIERNIVLLSNNAIVHPLVKHYFESFDGTCYKSRPWHTKVYPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH64</accession>
    <name>A0A914HH64_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH64"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16583.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16583.t1"/>
        <property type="gene ID" value="Gr19_v10_g16583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16583.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7966" checksum="DFCEA329DC87A87A" modified="2023-02-22" version="1">METRKRPEPPERMEPEERQTEEAGRVTNLKKPEETKTEMILVPEKMEMKKRPETPERIEMECKIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHG6</accession>
    <name>A0A914HHG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17395.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17395.t1"/>
        <property type="gene ID" value="Gr19_v10_g17395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001896">
        <property type="entry name" value="insulinoma-associated protein 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042972">
        <property type="entry name" value="INSM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065">
        <property type="entry name" value="INSULINOMA-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065:SF4">
        <property type="entry name" value="LD18634P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17395.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35904" checksum="B8ABDF1B64FF7F56" modified="2023-02-22" version="1">MFSSPSSSLLASLFSSSPIFHPPPAIYSNSSAFIAPSSSSSSIAASSSSNAVSDAFRSLSLQLLLDQHRNSLLRSILALTTTSTVPVDANSPYSTPADDCLKTEFLLSNVETEKSAVEGSDGEKRREAENDELKKEKKREGRKRPRKERRLKDERNRKVLRLHKGETETDSPVSGMFIREFCDEEELRQATAELDESAPFCNVTEETRTAISAIPDVIGDTICALCKIRFGDVFRLAMHKCPRIRHEEYRCDECEKIFSCPANLASHRRWHRPRTTDAPAASCIATFSARERAKAETEQWKMRTDEATAKKPVELARGETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI90</accession>
    <name>A0A914HI90_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Annexin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HI90"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17610.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17610.t1"/>
        <property type="gene ID" value="Gr19_v10_g17610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF243">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037479158" evidence="4">
        <location>
            <begin position="28"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17610.t1"/>
        </source>
    </evidence>
    <sequence length="612" mass="68574" checksum="FEC9A317531CE078" modified="2023-02-22" version="1">MPPLSSTFLLCFFGFLLLPIAINTKEACDGAQFAEMPCRCCKMDCWYSMAGLATHELGHIPGEAGEREALATLRLIRACMVAECTPLCANNLMNGAETVGDEPQRPNNRKQAVHRLAGMPGAAQSINPDELGEFVRCQSVTCRRHAFAQCRRSPSAAELMYRFFSVAEEAVSGAASATVSAHSNYRNASTPLLPSPEMLDSVQLRVPAPPTNGAAIFGVGVGILNGQNEETEQQQQRKRMSIFARQKSSSEEADRKKRLTMPLIYRMYESQSEDFCGSVRGPDDDDFHPEEASKSLRQALAAGIQSHDKTLIDVLLAHNNFQRQKIATAYENMYARSLADDVEEESGGHFMESILALLLPAHVYSARTLFFAISGKSFERSAAVEVGLTSTASQLGVIRDTYQNEFRVLLERDLSIKVEGLFGKMLAQLLLRKTDFADDLDVEEARREADVLFKEGNVEELGRSLELFNRVFGLRSPRQIQAFVERYDTLARDAQNRSENETASGRTESRTVRNFEWTIRKSVNIHSDIKQAILLYARISKNMQLYFAEKLHEAVSQARPDHQTIIRVAVSRSEIDLYDICNEYRRKYGHHLVYDLQNMCSGDFLRLPQPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIM0</accession>
    <name>A0A914HIM0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIM0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17715.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17715.t1"/>
        <property type="gene ID" value="Gr19_v10_g17715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17715.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10976" checksum="C3A7EA304DD8AA20" modified="2023-02-22" version="1">MAGRQRLILAEAANVRAANVRKWGMKFLHIMAANVWTHQKIFRQRKSLWESEQITDFHSNLTPLALCRRRTFVIIIPSFICTFEQLKSLFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIS3</accession>
    <name>A0A914HIS3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein zeste</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIS3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17287.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17287.t1"/>
        <property type="gene ID" value="Gr19_v10_g17287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17287.t1"/>
        </source>
    </evidence>
    <sequence length="566" mass="61326" checksum="E53D7C40A963736F" modified="2023-02-22" version="1">MHIPCSSYSKAFPPLKVHFPRSRQRRPNKSSFKRSTADPSIPPPSSPPQSFHSCSFCWCALPRSPPLPSTRPVSSRILLSPIPQMVSIMRSEQTLRLIQLYHSNYPEIARNNQDADGRNLKLQMWAEITNELNRTFETAFSVEQFKKKVQNVQCTSRQKLFSGKRNLGEAEVEYLRLFESDKISVDTLTHRAKNRRVSINSADFLMLRERHHLGDYGVNSDNIDEEVKIGVEEEGEDEEAEEGSTTGGATGKATTDGGGRGRLCGGGGEGMDGSGRGRMNGEEVEGRGGRISEGAEEAMNGSSGGAMNGIGEVNESSAVTAALSTIGALFGAYGGGAESAQMDAWTQQFLLAMVNATMNGATEAAENVAGGVDDNGNRATTMRRRERKRTLEEDWGEEEEEEEKEEGRPEEEKNDWGGGGPVPKKTKHGRAEEKHEAGEGTESSWAGELLKIQREVLGQQREMLAQFGNSVSKVIRLASSSGAVSESAPSLPNPSPASSSASASPLPSSFASRVGHCQCSSNRNCSGALLSLERELCTRLDTTNAMLARVVELLMERLSPLGMPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ88</accession>
    <name>A0A914HJ88_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Pseudopodium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HJ88"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17680.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17680.t1"/>
        <property type="gene ID" value="Gr19_v10_g17680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097723">
        <property type="term" value="P:amoeboid sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007060">
        <property type="term" value="P:male meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031272">
        <property type="term" value="P:regulation of pseudopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF485">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="12">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17680.t1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39985" checksum="D66C7F1D005BB8A6" modified="2023-02-22" version="1">MVTRRKSFACSSIDIDNVIARLTSPAQQTNAQWRHGVDVSESEVRALCMLSRDLLLSQPMMLELSAPLKIVGDIHGQFTDLLRLFHNCGFPPKSNYLFLGDYVDRGTRSLETIILLLCYKIKYPVNFFLLRGNHEVASLNRIYGFYNECKTRMNIRVWKAFQDVFNCLPVAALINGKIFCCHGGLSPYLRTLEQLKRIQRPADVQESGLLCDILWSDPDPKVTGWAANDRGVSYVFGVDVLQQFLSRMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDRSLLCSFQILKPSCSPLRERKINVSVELGGAAGGGGGGGTTAASVKLMDRPKRVRSNSPFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKG0</accession>
    <name>A0A914HKG0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKG0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1952.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1952.t1"/>
        <property type="gene ID" value="Gr19_v10_g1952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1952.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30717" checksum="DC14CBBE14050A34" modified="2023-02-22" version="1">MALIYASAVNKRMHQLQKKRSMDIPTQTELSGQPVSFQCSTKSRCNQQLEELSNARSISRDCSGEARKHSAPPSSNRSCAVYAEKSQIVKLSSMDGGGTKQWRKLTVPSGQFNGDNENGGTADVALPCRKISMPQTTTTMPTMIMLRGGTALDRAGGLATAHAEVARTKRLIRAKKTSNNSTSPSHDECDDDDDEEDGGDEQAGKNGVRILDHFTSAFRRRSVSMDERVLRRRRARYGTLSSSDSLGSPTGDDVGDGIGTRKLSAFRKMRERLNKWKLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKI1</accession>
    <name>A0A914HKI1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g2316.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2316.t1"/>
        <property type="gene ID" value="Gr19_v10_g2316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2316.t1"/>
        </source>
    </evidence>
    <sequence length="1368" mass="154241" checksum="6E1F5F76C52205D5" modified="2023-02-22" version="1">MDPQNQQIRQQRPESMQNSQQMRAEQLAEENDNGNQGLGQRGVQENVQRFGDLRNPHPGRFRYLLRPRVNHPYYGYNPDESDSYSEEIQQIPWDQTYGILPQNERGDIQVLERHSTQNTAGENSHPILHPNPQIHLADQEEGRDRYGRPIAISTPVEEVHRLFVIPPPPQNSAQNSPHISYGLNSNSEEHFGREAVEVQQPENFPRGNFQGQFRGGEQIRYGVEQGRNVQVIQNQGERRNHRDHPHGNPPFNRNCERIRNMGTFPRPQWAGNQNFGAVRQGVLQFRDPEERGRRYGDYPHGNPHIEHNFRGGQEIRDYPQQNWAGEFNQYAGGNAPGVPPMPGQGLPEIIMELHKVTLSNQYASVLREIPSIQGTEGRDKIQEFFTTLEICTKEWKPEKRLEILRAKLKGKAIKALNMALKKFGPQAPFGVLKTEITSILRETDHREASAFNELMQAGKQKGGEDIVKFGERIQRLVCCAYSGIEESQLDEISKKFFIANINDPSMARFLECQSKPLQTFDELLMMANRLSLVGKEPTEKPSQSNSTQPYQSFRPITQYQNFPNFSARSQISQNRQNPPPRAPQNQMYANRYEPRQSRQPNFPQNFGDHQNHIVGTRGYYQNENRNNQATGANTTPVHRQSQQGQNFQQGQAFPAPRTDANTLIVTEKSAKNAEGTIIFGNVSQKNSPEYEKFFNALTTHALKFPSQTPAQPKTAACLTVELEVETEKARALMDSGAETNWGFNPNSGPTKIPFDVASISGTRIPIIGVINVPIDLAEMKTEIPCLITAESFSYDLVLGTYALDRLGYYLGNKSTFLIEHKDNFIPAKMNGDEELMDFEEEEDHRELERVQKLDKEAERKELERLGIIAADHQPRLKQFAKRSRSEPPIFLSEQKVPRHEMAIIERSLAMSEQDRGETDGIGHNSVCSGVEEHGNCAVITLGTVIPSLSAMDKLRDVKVETLGELISLLIAKDVPTAQIRNWAAQRNTHGPDYLLKFSSNHSPSSQDFIPIISLWVDRCDFAFRQLQLSGCKKVRFPIPRDNKNYPFQKQVENAIEEVKARRVLGLAKVSKNPFILYADSGGKVMEGKLETEIILERSCTALSNEVEETYFGSEVREVLIFIGTDDINNGIPIEISKVAIQKIASHMSKFSHKTIFVPPSFISDKASGHEKFLKMLEGCVPKEGKISLALTRGYRSIAEITRYGDKEENRNVDGKGQLKPGGAKMILKFLRAVFGMKTPISESKSSDPHGGNRSEEHPQPQKLAAFSFPQSSQIRPTQSGSRPNYRWQSYGYQRGNRGSFRTQNGMHSHRGTARQHDNYGNSWGGNFSGSAASTHSNSLGPGGPQLLQAGRADASTPRRSSAARERGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKK8</accession>
    <name>A0A914HKK8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKK8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1995.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1995.t1"/>
        <property type="gene ID" value="Gr19_v10_g1995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1995.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23450" checksum="F2AB98C947CBA3B5" modified="2023-02-22" version="1">MARSDDKWTCWYGCHVTEGAYKMAWIFTIVNILGGLIIVLSFISTDLNAKTTFYTMTTLVSLLSWLPILFGHFCGIRSHRMYLPFLSLFAIYTVYTFFEVLYFVLQRLLMFKSPDSIYVMFGVSLKEYENLVGSSTSAFALFVLSMIGILACWCWVYSIVFRAYKFTKQIDGDGTLNETKIPYGKMAKYGCILTKESLQFKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLD1</accession>
    <name>A0A914HLD1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLD1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17694.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17694.t1"/>
        <property type="gene ID" value="Gr19_v10_g17694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17694.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29398" checksum="0BD8FF518558E764" modified="2023-02-22" version="1">MQIIETNGLELIRLTSYRPLQPADRQFEPGLKTTCSRFSARHHRKFNSPNQNNNSPPPAMRRQLLWLPPELVYELTLLLPICDRIPLLTTSAVLFGVLTFGKAKNRLYVFVIKARERSFLHSEVGPNGERPLLPRIHSQRLPPMISNLRFYAEQPALGGTVFQAILLLDPGRFPPTVNVDANFRWEFCNQLNFFCTSTTALWGGGMLVVDALHLPDQEYDLCAIKAAGVEDDVLKGHLRDCLRDIASFMDNIYPQQLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMD5</accession>
    <name>A0A914HMD5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Battenin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HMD5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2122.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2122.t1"/>
        <property type="gene ID" value="Gr19_v10_g2122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2122.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15190" checksum="0AF69C2BCAF6F5D9" modified="2023-02-22" version="1">MEKKSLIRDLIAFWIFGLANNFAYVIMLSAAEDIIKGQTASSYHENSTKNTSVAQICRPVLPKPRCEITSTGAILLADIIPALIIKLFCPFLMDRVPFGFRHFVVCAMQALSYIIVQVWVKIVCWPYLHITKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMI8</accession>
    <name>A0A914HMI8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HMI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1955.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1955.t1"/>
        <property type="gene ID" value="Gr19_v10_g1955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1955.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37055" checksum="663904713D04BFBE" modified="2023-02-22" version="1">MALNSTAFYFESIRNEVYNKFAEERPSWTLVVFASIYTFVASVGIVMNFLVVFVTIRTKELKGSANKLLALYSLFEMVHQSGHFLFVYTVFSGHYLIEFSIAVRILSPSFFAFGCTTLLLFFTSIDRLLYVLFPLRTAQNDNAIICCVVLPIAGMFGAFYVGSLNLNCGSFDEHLIFGTMTDIGAFVSIQCDNWVQLLYEIVTIILLAAIVIYVLIAILLHFKKAPSNSNSNQFNMRIFRSLFIIVSVNISGYFVMNFYVAIILPYIVLLPMAFWKWNQIISIVLNVSAASNAPILYLSSSEYRKAFRKELKPFIKIFSRNSVQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP50</accession>
    <name>A0A914HP50_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP50"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3349.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3349.t1"/>
        <property type="gene ID" value="Gr19_v10_g3349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037572426" evidence="1">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3349.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16202" checksum="6130BDC2D579DEE3" modified="2023-02-22" version="1">MGEFWILILVAFFATNSFDKSESVKLELKTFDEIFGEGWWDKGAAAEDLKTRRQQTLDKMSIIKSTDRTPKLDKLNPIQLISLDKLNPIQLISLDKLNPIQLISLDKLNPIQLIRIPLSQSLITLIMLKMSEDVKLSTNSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRS0</accession>
    <name>A0A914HRS0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3121.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3121.t1"/>
        <property type="gene ID" value="Gr19_v10_g3121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3121.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10921" checksum="91BF148997178D5D" modified="2023-02-22" version="1">MHLAIELLDKLAPAMVTSRSEQGLPERASGMAQALQFARPPHRHASHARRVTKERPGRLVPRALLARRDSPEHVDLKGICPKYCAIDGGVFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HST5</accession>
    <name>A0A914HST5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HST5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3641.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3641.t1"/>
        <property type="gene ID" value="Gr19_v10_g3641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="124"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3641.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="22249" checksum="9FD04B1E7B3D1337" modified="2023-02-22" version="1">MASPFDFFKKFFVAGKNENMNYYELLGVSEMATSDEIVKAYYERMMAYHPDRNPHGVAMSRLFTKAKETLTDPHKKAIYDQRMYSYATADHHQQGEPMDFFKKFFVADKNENKFCFAGKDENVNYYQLLGVSEKAKTDEINKAYRERMMFYHPDRNAYGDAMARLFMKAKETLTDPHKKAIYDQRMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT39</accession>
    <name>A0A914HT39_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDK2AP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the syntrophin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HT39"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3512.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3512.t1"/>
        <property type="gene ID" value="Gr19_v10_g3512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017266">
        <property type="entry name" value="DOC_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041428">
        <property type="entry name" value="PHsplit_syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF1">
        <property type="entry name" value="FI16515P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09806">
        <property type="entry name" value="CDK2AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18012">
        <property type="entry name" value="PH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="477"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3512.t1"/>
        </source>
    </evidence>
    <sequence length="918" mass="103778" checksum="C56F883318F85633" modified="2023-02-22" version="1">MGAPTNELLSVIRQIALIPNCLNSFNWKKRRPMKQNLRDIFDRNNEQQQPAVVETTRRQFDHCAGTSPSPAPPAKKERSEPVEGDEDNEREHLSEFIRKNRLIEEAELVEKQLSNYQRCTELGLPARIHLPVGTGPRRSQRQCRRFTTFSNTHACQFDAERRRADVPPRDGDLNESSGYKFWSMDSAGEKLPPPPPPPPPMVTAALTAQKVVQRSTTPIHLQQQQQAAAAGVPASSSLGTASLPQYHVNPLSSCVAQHGMPASKYQQLLMVVDELGRDIRPTYNASRNAQERLKRSIIQARVMVRECMAELEQQRKQQQQQQQTNCPLFFNAFPLVFKQFSARREATARCSSTTVRLLAWLYTNCRSGEAVRCLSLADFLHYFCVQIENNYLKMTRKHSVRSLDVVHSGLVLWQRDGKMPRRECMARLLLTKDVLSVQVPAGSGEEELNPLQMTIGSTSDVAAANGRATKQFVALRTVNVPKGSEGLGLSIKGGTEGSHHVPIVISKVLPGLPAAQTGQVFVGDLIVEVNGISLEGKTHEEVVQLLRDSPAPHVTLTLKRDNKVSPLLRDSECKHSLPSLMDLAVFKSALKSPAEELSDERRLEDESGGEEWKTAIRIPLPLAFLSRNLWATDKLRSNAFEVRSVDGRASGIIHCEDRRALEQWVNHINAHINVLNRKSMRLSNKYLHATDRISYINWVEERMPDGHFEDAKQRWERRFLLFKGANLCLFESPPLNADELDNCLSMNKVYETALRTAIKRSDRREHVFALATVRDSAEHYCSFQSRDQLHQFEMAYYSCMYKAVNTIQTRTFACSYDGRPAGLVIDLRLGFSLYDIPTKCYLWQYGFNELEASSDDGKMRVQFIFHNDVVVASTGIRQLDVKDIECDEPLVLVFTLHSFYIAKVMGTDPEFLQSLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUN3</accession>
    <name>A0A914HUN3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUN3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3927.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3927.t1"/>
        <property type="gene ID" value="Gr19_v10_g3927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3927.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16215" checksum="0C4C831936B9C502" modified="2023-02-22" version="1">MDQFGVGIVVSGGRKMRHMRHRKCDTGKCDTGKCDTGKCDTGKCDTENANRKMRHRKCDIGKCDTENANRKMRHRKCEPENATPKMRHRKMRHRKMRHRKMRHRKCDTGKCDTGKCDTKLENATPENATLENATPEYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV18</accession>
    <name>A0A914HV18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HV18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g474.t1">
        <property type="protein sequence ID" value="Gr19_v10_g474.t1"/>
        <property type="gene ID" value="Gr19_v10_g474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037781703" evidence="9">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g474.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31235" checksum="74F7C67D677F4693" modified="2023-02-22" version="1">MNTPKFVLLLLAFSLYYKLGDIVHAASGNGQQQHEAGGQCDKNSETDFDCGDGELRTRCITSFWHCDQVFDCSTGKDELDCMYLHKCPAGHIACRNGDCFLATSRCDGHNDCDDGWDERGCNDVKRSTAESSLNTVEKIHNGPADEEEHENDLDITDLEGQAEAMVDESDRETNSVASFLLFSTLLFIAVSLVGLVIFRRYPNTVSRLDETFKEFNQSISSSARTLLSKGRASSVQSHVTITTPANNNNDHQFFDNPLHLQNPLVLGVHSTAPRSTIGQPPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVR8</accession>
    <name>A0A914HVR8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVR8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4619.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4619.t1"/>
        <property type="gene ID" value="Gr19_v10_g4619"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g4620.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4620.t1"/>
        <property type="gene ID" value="Gr19_v10_g4620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4619.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4620.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7844" checksum="DD3509D6973E3A17" modified="2023-02-22" version="1">MRWRAFAKCVEKTVRRLQLERKDKNRRNPSTETSSCLLANVLEWAGRVWSLLNWDGRGGRPPTASMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW66</accession>
    <name>A0A914HW66_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HW66"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5228.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5228.t1"/>
        <property type="gene ID" value="Gr19_v10_g5228"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="SRRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239:SF41">
        <property type="entry name" value="MEMBRANE ASSOCIATED PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239">
        <property type="entry name" value="PROTEIN CBG20215-RELATED"/>
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        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="528"/>
            <end position="566"/>
        </location>
    </feature>
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        <location>
            <begin position="179"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5228.t1"/>
        </source>
    </evidence>
    <sequence length="717" mass="81715" checksum="51A80592E11599DF" modified="2023-02-22" version="1">MGRCCFRPRRFPLIIWPFSLIFLFFVGKGYCRSGQRTKDFSCASSLPPGHELCAQGLCFDLFRTDTEQIVSGCAGSSDLCAVSGCSLLADRQAFVCCCAHSFCNAKSSALVRARWRMFQKGDYPLGVEGGRWRKSARNLANERGQGEKGREQSLNSTTKILIMTTTNKPKTTTWSSTFRKTDEGVGGMKEESAEGKTKAMSRTGEENKNVESKGEGERWVDQRMDVAKTREREEHEKEQEKRTNEEEKKRKEKEEKRTNEEETKRKEKDEKRTNEEEKKRKEKEEKRTNEEETKRKEKEEKRTNEEETKRKEKEEKRPNDEETKRKEKEEKRTNEEEKKRKEKEEKRTNEEETKRKEKEEKRPNEEEKTLTKMHSPQSSIINKSSSPPTATSFSPLTILPATTLFAPKAANNGQEHCLDFNNANNENKSAIEEHCLDFNNANNENKNAIEEHCLDFNDAVVILKNNAIILDIFSITIFLNFFFIFPEFFTNNVIFALPHKSIVLNTINDHNRIRGSQKKKDGFVERNCPFTVSSSTNRSDRTTRSPEAVEEKGGQSPTDERQRKAQRTAEDAVSAFPWYWVALAGFVCSSAVFSLVYLTFRGCRRIFNKRRNNSRESIGEAAATNGEAPIMMANGGKAAGWNRKRRVTKEGKRGAKEGLAVKGKTATNDSLMSHCTTSTAVTTSTNEKNGSSGFEGGEQMTVLDPLLNQEWSGTLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWI6</accession>
    <name>A0A914HWI6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="WBParaSite" id="Gr19_v10_g4419.t1">
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        <property type="gene ID" value="Gr19_v10_g4419"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054277" evidence="2">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4419.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19945" checksum="E2B7B0A2DDE804A0" modified="2023-02-22" version="1">MANDNILFISGVVLLALAIDFSPAPACTTVIIFALYKYRSELYELLPPEFFDVLKRTRALYMTKLKRWFPDWQEMPCGIGAVYDSFKKTLIEIRDSTTLAIIPACSNLPNLAKTILDAISIRPGLLNRARRVFIGAVLIFAVGSLFIYDLKTIVSTYILLAFIAVFVKFGFDNTDDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX22</accession>
    <name>A0A914HX22_GLORO</name>
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        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
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            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX22"/>
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        <property type="gene ID" value="Gr19_v10_g5268"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
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        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF301">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
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        <location>
            <begin position="202"/>
            <end position="289"/>
        </location>
    </feature>
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        <location>
            <begin position="311"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
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            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
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            <begin position="366"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5268.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="38620" checksum="37E7AE70F9C54B78" modified="2023-02-22" version="1">MRLKPVKRRPAAFPKKGEASSDGIQCVAQFDDLSLALQLRRIAFVAISVSTFTIVTAVLLLPMLYNYIQYVQHQIQLEVDFCRGQSNELAQQFVRMDVHNKNFSLLAKRQKRQVSTRKGEGLTRENTASNSSGGNKVSGIASLSSKRLVGNQRRSPYVHPPSVPPPAYASSYTVPPPPYSSASPSLSSSCCSCAIGKAGSVGPPGMDGPSGNDGEIGQDGRPGEDAALGAQPVHREFCFGFSGNPGPPGQPGKPGQPGYSPLPGFAGLPGEQGKPGFPGNPGEAGLPGLPGVLIEVEGQPGPMGLPGLQGVPGLPGSPGLPGAKGHPGPQGPIGDLGKPGKDGYSGKEGQRGLPGFPGAQGGCDHCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXP0</accession>
    <name>A0A914HXP0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXP0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5080.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5080.t1"/>
        <property type="gene ID" value="Gr19_v10_g5080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037414580" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5080.t1"/>
        </source>
    </evidence>
    <sequence length="1109" mass="123347" checksum="8359B194CB6272FA" modified="2023-02-22" version="1">MAFTVVVLLVMRMFMFVNPQQQLPSSDIDALPSNNSNKDFRSSCELLVQCELAINRSRMAISERCGLSPEFEELFRLSERRFDEFGACVLTEDGPSNGTEAECSESELSSIGTTTPTPESGCWRSLAGLREQCQRLQQCCKTANGCMVNIGTSDATMALRAQHIKINQKTLQCRQTHHPQGPTSSAAVDSSPLSETEIFSPGDTGPSPAGPPAPPVSARLHSVLTASVPPRVIVPTRAKNGKSLPKGRIEQFGETKPPPSVGGRRSSRRLSQYMADHRPIGIFSGTKKKKALNGDKQKTAAAPLRLVGHKLRHTFALPARLNFRRLRLFAARSHRDQHKKQAVQQLMDYHRQIQAVHHKTEAEENDWIFWQRWPRKEGKGIRVASATLTPSVPLLTPNFVPTAATTLPLAITVSPRPSADTVFFSLPTVFPTLMTTETKTETEMKRTKTEDRDKEGLASSSIKPPRKKSARLSQFSARPKKVYRTSMLRLIAHRQPEGFALPSRLDFHRMRLFAARPELARSFASVAQRREHFRRLRNWMDSFGRDQKEGGAKAAKRDRIGLAQIEAELSFSPTSSSPPKTSPPPLPPLIVLSSTPSAAMFPQIWTKPYPRGPNGWGELEAQLSTPEATTPAIGTTATSIGERNSPNPPPRNNEQNGAVVDKANELLPSVTPSAEKAPSLMQTAETNVLFELEKQRKSKTRSEGNHFQKEQQKMELSLLDENSEQYTDEIPTTPTTTTTTPTESTTKGTPPTESTTKRTTPTQRFGGKSRSSGRARSRAHGVVPKHAGEARRERPLPPPNSSTLHSSLDGDNSLLSPLQKGGGYRRKVLLLAHQMKRLGALRKDRKPMLPLGIRRAPPPNKRIGRPPSPGVPPPPQLLVFSQSDSDEMKRISGILERFLEKHLLEKKGWNNSISQPPDQSPLSANHCFLFVACMLQLRSLQSDHCRSLPEAGRPVPGPPRRRFGRCNSRLLPLFERADSARAELERGAEECLEENVRNGTARAKSSCPSELPVQLPLGSNLECPERVALLHQHCKKLGRCCETLESCQNRVGTSGLARRVRLEEEKLAVRSTQCQKQAHEMFRILRDKQRADEELLRVKRRRKMKTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXP1</accession>
    <name>A0A914HXP1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXP1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4991.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4991.t1"/>
        <property type="gene ID" value="Gr19_v10_g4991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4991.t1"/>
        </source>
    </evidence>
    <sequence length="463" mass="50129" checksum="C1AD68B1D037AA67" modified="2023-02-22" version="1">MGTLDIMAAPVTHYLSSQKPSLHGVSKLSRWTKLEPKNQTPATSPDQQPSSLGSQAHSSAGSDTDDSTHSGTNSQRQSPHFGQQRVLGGKISPMLGQEHFPILGGWNVNAKSFQPVASSTGGGHLQSSPHSMCQPVVGDFSYPPPPIVANSFYPAQNSTNHAYLGGIPSTFVPSAEQHRQREAADPLGIGGAEMMGVWQDPNAGLKQWQTYTGTTVWGNPDEKANLPIQRWQSFDEEACVEMLPRLDELAKKLPGTVKGWGDLPTMDSLPAPLQRVQTHQATAITQVQQRPQQNHQHHNHQTQNYHRRVHNPLNRQSTVDYPFANLAPPLSGPYQLPHNNIPQQQMGGWPSNDGFVFRQQRTGFAMNGGNNLVPSFNNDSTVATPFNSVGMGGVSGGWMCGGEMTTNDGMDLNNVSLRTEQQHHQVSSRNFAFPSTYFPFSGGDCLSSTNGAIGVGGTVNPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYN9</accession>
    <name>A0A914HYN9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasmic vesicle</location>
            <location evidence="1 12">COPI-coated vesicle membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="12">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HYN9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5248.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5248.t2"/>
        <property type="gene ID" value="Gr19_v10_g5248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000008">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="319"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="595"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="638"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="795"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="885"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5248.t2"/>
        </source>
    </evidence>
    <sequence length="952" mass="106519" checksum="D27AF09BDDD5C515" modified="2023-02-22" version="1">MPLRLDVKRKLLARSDRVKSVDLHQHESWMLISLYNGFVHMWNYDTQQLIKSFEVCELPVRAAKFVVRKNWIATGSDDMQLRIFNYNTLERVHQMEAHSDYLRSIAVHPTQPFLLTSSDDMLIKLWDWEDKWKLKQTFEGHTHYVMQLVINPKDNNTFATASLDKTIKVWQFGSSMPNFTLEGHEKGVNCVDYYHGGEKPYLISGADDRLIKIWDYQNKTCVVTLDGHSHNVSAVCFHPELPIIITGSEDSTVRIWHANTNRLETTLNYGLERVWCIIAQRGSNTVAIGYDEGSVTINLGREEPAVSMDASGKVLWARHTEIQLANLKTIDEQTLDSLQDGERLALAIKEMGSTEIYPQKVQHSPNGRFVVVCGDGEYIIYTATALRNKSFGSSLDFAWANDSNLYAVQESSQLVKVFKNFKEVLQIRPDIMLEGINGGHLLAARSAGSLLFYDWDTGHVIRRVEIAAKNVYWSENGEMVAIGGDQSLYILKYNADAVANANVADIGPDGIEDAFEVIGELSESVKTGFWIGYCFIFTTTLNRLSYYVGGELVTIAHMDRPLYLLGYLAKENRVFASDKDHNIVSYKLLLSVLEYQTAVMCRDFDTADRILKAIPESQYTRVAQFLEKQGFKKQALAAQQADSEEKWKQLAHAATIKSELRLAGECLAKANDFGGLLLLASCAGSNRLMAQLATESHSQGQHNVSFLSNFLLGNVQQCIDTLVENGRIPEAAFFAHTYAPSQVSHLVALWRDAASQNLSGISKRNIGESLADPLKYENLFPGFAEALQAEKQRDVGAEDVQTVGSSSKTIASEAPNLMVEKPPTLPENREETSLLPPTSEGSEGDDEQTHRKDQDFTSAISSMSSLDKLVDADDDSDLVVQHLPDHQQTQPDQQQQQCPSSVKGPPGETLAGENSGEEEEENSTRKGFFDNFADQTLVEREQAEVLPPFLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ24</accession>
    <name>A0A914HZ24_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ24"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g599.t2">
        <property type="protein sequence ID" value="Gr19_v10_g599.t2"/>
        <property type="gene ID" value="Gr19_v10_g599"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:cytoskeleton"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
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        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="845"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="974"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1068"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1101"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="10">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="10">
        <location>
            <begin position="456"/>
            <end position="492"/>
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        <location>
            <begin position="865"/>
            <end position="1123"/>
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        <location>
            <begin position="1169"/>
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        <location>
            <begin position="1174"/>
            <end position="1184"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004245"/>
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            <dbReference type="ARBA" id="ARBA00025722"/>
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    <evidence type="ECO:0000256" key="10">
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            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
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    <evidence type="ECO:0000256" key="11">
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        <source>
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            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g599.t2"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134108" checksum="18D7D3CC71DE9F2E" modified="2023-02-22" version="1">MHQNFFWLLPKMDHWELLEPVDISSKLTIDFESNKWQERKEAMDELFQLLTQNPRLADSPKYREVIERLTKAMANDSNINVVTSAAKCMAGFAKGLRAKFAPHVLLVLPVIFGKFKEKKQILRDALIECVDAVFASTTLDHLSNAMLEALASKQNPSQKCQLDLFIYRIFRSLAPKDVPKGFLKDLVAALSKHGSDADPEVRDSSFAALGAIMKCIGEKSLSVFLTPELVKDANKMAKDKAQSEAAAMLSLTMMANAHSDCGRTSTSSAKENAFIIQNNDEMDHWELLEPVDISSKLTIDFESNKWQERKEAMDELFQLLTQNPRLADSPKYREVIERLTKAMANDSNINVVTSAAKCMAGFAKGLRAKFAPHVLLVLPVIFGKFKEKKQILRDALIECVDAVFASTTLDHLSNAMLEALASKQNPSQKCQLDLFIYRIFRSLAPKDVPKGFLKDLVAALSKHGSDADPEVRDSSFAALGAIMKCIGEKSLSVFLTPELVKDANKMAKDKAQSEAAAMLSLTKPKKQQNGFYPSPVDLPIKQQRRILNVLSPRADCQAAECRVNTSSSKKSVPSVVSVSKSRPFTAPSEASPTCNKYSFDYVNTPSAEFVRLGHRQTEISLKLKTAFKNPGAFLSARIQALDFHMCTRMIDVGLNLGMGEVALRFSPAAFGLLSAINSKLVEHQQKKPAKTTDRPMMPDYPNYWLPKQIKRRQYWWFKRPNSTAGELATFSIRRFEISLDAEVRDTMRPMGRVWQNWKLALKIGPQEDEVEPCVDAKRVLPFPKLAVVIEAAETTKEREIQFATGKEATRGKSKAQRQMLSTEDINSALPYCNVCLGSTDANYQIYNLVISGTVLALIGMAGLAGNLLVILVYSNHRQRFHSISVYLMALAVSDFLMICTAMFLFVLEAWRHHGPMGLAYAYGVGAPFFFPLASIFQTTSVYFCVGAAIDLFVSVALRGPISESYCTVRIARKFVLITACLAVLYNIPHFFELRSIDCFETRDGLNVRSLQICPTEFRMSHVYYSIYYTYMYTVFMAVGPLVLLIVLNICIVVNVLKRPHDPDSDIISLILVVFLFIFCNFTALLVNFLELTFSEQLKHVIVYLVDLSNLLVVINCTANFFVYLIFGNSFRRTLREICFGKAPPGVGTGGEMANGGARANLLVLMESEEGNRNGAPSNGQQKNGTAPAAAKAKTAIVRIIGTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ42</accession>
    <name>A0A914HZ42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ42"/>
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        <property type="protein sequence ID" value="Gr19_v10_g60.t1"/>
        <property type="gene ID" value="Gr19_v10_g60"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036995930" evidence="3">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
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            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g60.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25234" checksum="2976CDA05C747AEF" modified="2023-02-22" version="1">MMLLLLLLLLLLLLLLMSKQLLRDAKKDPSTSSQQAPSIVRMPNSAAQKTSSSPTVVHRQHPHLCMFGIMHLATAIKLIIIVGLLVIAALCTVEAIYLRRALIVMALPLAVSLITVAALCRGEPRLLWPIIGISFFHLFLDGYVCIVFLFLFFFKPLYIIMVLNWAFDTLHTTKTVSFYIHCGIVFTALFTFFIFNLWQLRTALRFQTFLEEVGGHFILFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZW1</accession>
    <name>A0A914HZW1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZW1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6018.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6018.t1"/>
        <property type="gene ID" value="Gr19_v10_g6018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6018.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12110" checksum="CF28FF8AFE2CF439" modified="2023-02-22" version="1">MIQGLKTRFRNLIDKKEIAVGQFLDPRLKDRQTEFPDFFRQKVFSYYESGCTPIPFAPVHQRLERTNIFFGSRSFSLPSYADRSSQFRYPRHSILGLGYVAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZZ1</accession>
    <name>A0A914HZZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g622.t2">
        <property type="protein sequence ID" value="Gr19_v10_g622.t2"/>
        <property type="gene ID" value="Gr19_v10_g622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1560"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g622.t2"/>
        </source>
    </evidence>
    <sequence length="1780" mass="190263" checksum="E4E0FC05ADB2C69D" modified="2023-02-22" version="1">MDWLQRHFLAVAASISPTRRKSSRRRSPTKRRNGRTWKRTRSEPATVDIDQRVILLARSSSSSSVSTEAGRNNKFCASTEAANSLSKRRRKAEESFGRQSVSFAVDSSAESQLFIEDQDDALFAFGTGDAGKTQKPPSPFKTFAASIVRRRQQRLKKGVGQELEMTKVNTKGVGQELEMTKVDTRGVGAGVGDDKVGTRGWGRRGGAGVGQTKVDTNGVGQELEMTKVDTRGGAGVGDDQSQHQGGGAGVEMTKGGGAELEMTKVNTKGVGQELEMTKSTPGGGQELDMTKVDTNGVGRKLEMTKADTRGWGRRGGAGVGDTKVNTKGVGQELEMTKVDTRGGGAGVGHDQSRHNGVGQELEMTKVDTRGWGRSGDDQSRHQGVGQELEMTKVTPRGGWAGVGDDQTRHQGVGQELDMTKVDTNGVGQELEMTKSRHRGWGQELEMTKVNTKGWGRRGGAGVGHDQSRTNGVGQELEMTKADTRGWGRVGHDQSRHQGVGQELDMTKSTPGGGAGVGDDQSRHQGVGRRGGAGVGHTKVDTNGVGQELEMTKVDTGGGAGVGDDQSRHQGGVGQELEMTKLDPGGGAGVGDDQSQHQGGGAGLEMTKLDTRGGGAGVGDDQSRHQGGGQELEMTKRRHQGVGQELDMTKSTPMGVGRSGDDQRPTQGVGQELDMTKVDTRGVGDDQSRHQGGAGVGDDQSPNTRGWGRVEMTKSTPRGGAGVEMTKTPGGGQEWTMTQSQHQWAWAGVEMTQADHQGVGQELAMTKVRTNGTPRGWGRVGDDHSPTTRGWGQELEMTKVDHQGGGAGVEMTKVDTRGWSELEMTKATPGGGGAGVEMTKVDTRGGAGVGETKADTRGVGAGVWNDQSRHQGVGHELEMTKARHRGGAGVGHDQSRHQGGGAGVDMTHTVDTQGGGQDLDMTKATPGVGAGVGDDQSRHQGVGRSLEMTKADTKGVGQELEMTKSTPGGWAGVEMNKSTPRGWQELEMTQTRHQGVGQELDMPKGGAGVGDDQSRHQGVGAGVGMTKVNTKGVGQELEMTKLDTGGGAGVGDDQSQHQGGGAGVEMTKLDTRGWGRRGGQELEMTKVNTKGVGQELERPKVDTGGGAGVGDDQSRHQGVGQGVGHDQSRHQGVGQELEIPKPTPGGGAGVGDDQSQHQGVGQELEMTKVDTRGWGRSWDEQVNTKGVGQELEMTKLDTGGGGAGVGHDQSRHQWGGAGVGDDQSRHQGVGQELEMTKADTRGWGQELEMTKVNTKGVGQELEMTKLDTRGWGRRVGDDQTRHQGVGQELDMTKVDTNGVGQELEMTKADTRGCSDFPNGIAPSSSRDNFVHRRQPNDPPNLNQFHAHPLDNGAFQQDSCSPLPVHRCPQLIAWPPVPPAASLVVDSDDFPSRSAHHHHRTVTTATTTIACTRRHRNVPLCLLPHGHLPSLPLASLQSAARHFLFAQQTQPPRQSPSKGGRVEASSKEVEYRRVPETDGPELAQEQSPESLKGQQQQQKRTNALQGVSQQQRSQHTQRRVLPPRRLRAVRPSVASPSPSSPRRPVSSACPQQTADSSEEMVRPYKLDVVLHMPELCPDELKRHAWNPEDRSLNVYVKEEDRLTMHRHPVAQSTDCMRGKIGYTRGFHVWQLNWPVNQRGTHAVVGVATKDASLHVPGYVSLVGLDAEGFGWNIVENKCNHDAQNTKGWSYPYEQPFTAPEKIFCLLDMDEGQMAFATESKYLGVAFRGLKGKKLYPAVSAVWGHCEITLKYLGGLDLIFSGAETAYGHLPQVDTGQCGQVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0D4</accession>
    <name>A0A914I0D4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0D4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5701.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5701.t2"/>
        <property type="gene ID" value="Gr19_v10_g5701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1470">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="6">
        <location>
            <begin position="131"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="7">
        <location>
            <begin position="276"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="6">
        <location>
            <begin position="352"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5701.t2"/>
        </source>
    </evidence>
    <sequence length="488" mass="54780" checksum="D29D322FA0ECF8FA" modified="2023-02-22" version="1">MIIENSLFDDLPRRDGSQSDFNVMCQLLRGLGYQENYSMRHMMEFMDEFAGRREQARPQCRVCGYDTWRVRFTVRHRRPYSKPSQVRGKAQFAKLPKFEWQTENVHYSSVPGASTRRDSLPQRRDGSCQRPVLRETINKDYLIALSTAPNYLSLRNLTLGTRFIQSLAAVFAEHAADDDILRLMIRVNAMGGGDRFSAHTSETHNSVPVHFSAISAGTLQCHQCRYTSVPSVPVHFSAISAGTLQCHQCRYTSVPSVPVHFSAISAGTHQCHQCRAVCVVMTHGEYDLLYGTDGRTVNLHKFVARLNSRNCPNLNGKPKMFIIQACRRHDRPGASTRRDSLPQRRDGSCQRPVLRETINKDYLIALSTAPNYLSLRNLTLGTRFIQSLAAVFAEHAADDDILRLMIRVNAMGGGDRFSAHTSETHNSVPVHFSAISAGTLQCHQCRYTSVPSVPVHFSAISAGTLQCHQCRYTSVPSVPVHFSASIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0Y9</accession>
    <name>A0A914I0Y9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0Y9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6484.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6484.t2"/>
        <property type="gene ID" value="Gr19_v10_g6484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2 3">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6484.t2"/>
        </source>
    </evidence>
    <sequence length="542" mass="62685" checksum="315121E3FE1160BA" modified="2023-02-22" version="1">MARSVIGNDTCKEKDWCENGGYLNPNDCSKCICPDGFTGPYCRLLKFNLNCEDTSGTPRELEAERTNKVLKPRIKCGANGKKARIQLTYLNEMFECVDPCKNYVLISYRKDKRAQGARLCCPAALRDNVTNAYKNWIESEEPNVDFIISAHISTDLTKPTTLFDLNYEAGTVKLTNSDACVSPENLYIEKRNPGTNLVCLNDSGRVDPKCLCNGKAECLSQQKWSNATWSCPVFVINGQIRKIMSEKDFHARRVVASVLLFQLGLFCSCSVPVLFCSKISEQHRNRNRFKIPGTGTEQEQNRPSWNRSKNSLLCSVPVLFLFLFCSREQEQEQVQNCWNSKTLVVATLYCFRPEGTPQSFWGYRENATIDLIRVDEVQCLHYKATGVKPEFKSLDVEHKQFNQKSTFDLDQLFNDTIVIIGEQLKDWCRKVCCKWTVLIIAILAIGGLLMFQFQEMSTKIEQQQAEPLERQNQIQFQFLSQQTHLLKSLVVNEQYSNNFWQFFTISTLAIALFASKFYIFGYRSFRHWTFRHWTFRHWTFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I114</accession>
    <name>A0A914I114_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I114"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6307.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6307.t1"/>
        <property type="gene ID" value="Gr19_v10_g6307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="109"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6307.t1"/>
        </source>
    </evidence>
    <sequence length="654" mass="72353" checksum="2F0A316F158E34A7" modified="2023-02-22" version="1">MIKIRGWSVSSLLDDHSSSVGRSVANSGASSSSILGTTNATTAATAIAESAARKKFSAKSRKKMDWLEKQRIRHQFLLEKMVSMNIVSPSTSPKHPKHKPKLGKFIYLLAFIAVIGGFLFGYDTGIVSAAMLYVPKNDDLKPMSNNWIGLIVSITPGMAGIGALLAGKATDVFGRRKMVILSTIIFTLGAIVCAIGISKWILLAGRILLGIAIGFASMIVPVYVGESSPAHIRGRLITSFQLMITFGLVAANIFAGGFSYIDPLNWGWRLMVGFAAIPSIIQFVGFLFLPESPRWLYENKSRKECEEVLSKIYNGDTEWIQFELAEIQMAHDQQKHDAAIYGSRNVFWRIVSTPHSNKCPASTQSCIIRGKLFDQQALEMSIIRFGSQLEQQRLGRRVLLLSSIIGVFIACLLLGGGFLLINRNSSAVQTNLYPYQNLFNTGNTEYAKCAKLSNCDFCTTDESCGFCAPDSKPGFCLPKDLQNPDMSSLTGPCAGHSNDASHQINNTKFEWRDEMCQNDKILTFLPILIMVLFLCAFAIGYAPLPWVLNAEFYPLWARGTCVALSTFCNWEFNLLVSLTFLPLNQAVTRFGTFFIYAGVTAIAFVIFYFVVPETKGLNLDEIQLLFMTKRERKRAVTSLKMKQLSGVDLSTVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I119</accession>
    <name>A0A914I119_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Triple functional domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g631.t3">
        <property type="protein sequence ID" value="Gr19_v10_g631.t3"/>
        <property type="gene ID" value="Gr19_v10_g631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1901"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="1216"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="1412"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1550"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1636"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1680"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1736"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1553"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1640"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1707"/>
            <end position="1719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g631.t3"/>
        </source>
    </evidence>
    <sequence length="1928" mass="223966" checksum="5384B996809DC9DA" modified="2023-02-22" version="1">MLQYHVIRRAEDIEHVLRDRVALLPGVRDRENRPIIFVPARDVNSHPDHLHNLLTYLYDVTQDDAKPRGFTIVIDMRRGTTWEIVKPILKFLQEYFPAPINSLPKFIDFCQIIREFGGSMPYDHDEWIELRKDIERIVQRICEILKNLDRISTEMDNAEMPVDVQSSQAANAKHQDLYPIIAAVPIDEFKTEVQSLRDRVTSSGHRQSVSTRNVSVMTSPNPDLLSVFPQMDQLLQNLVIRRNNVYYKWDSRKNDLDRYCQLKLFEQDAEELSKWICSQFNVLTHRFVLIGESEMEANRLLKEHKDFADSVNKIQVSYEQVITVGHRLLQQFQSIGMNRIESISQQLQADWAQFVGRIEQRTALLQIALNMHRKCDTFLKNAELWLPNVGVDPHSIRSEDELPTAVQRHNEFQKLYQTAYSEAFEETNKLARVLRKYFGESALQLPAWELVEEQIRQITRTNRELHSIWEARNETIQIKASSTVFNQDLNSVLNWLTDHGEPFMRRKIGIGVDRSTAAQFCENHDKFRAVAHNTHRNAEQIFHMVQIIIRDSDESTRTETLQRVEELRRRIDKFRKCIEHRTNLLCLASNFFLHYEEIMQWYARMDSRMGNIRIVPNSVELCEQNKDKFQSENDGTVQAYERVMVEAQQLLQSLKQQRELLEVDNTEATVHVQTLTRNIENRHQHEKERWQEQRIYLSAALKISTFLRDCNEINKQLESWRQDLEGLKHSVTSTVEIIKQYHTQNTVKVQQVVSDAMKQLSEILQLIHAKNLQLLCAVEPSQPLKEMVTTAANRLHNLEQEVMHIAKDVSNRIELSIQLGKLRQIANGVIGAVEREQMRLMQLYFIPGNQQEVDMELRYFHEFRIGIESTEENVNRFYDEKEKFSNLLTLALESHAETRVKAENLCTEVKTKWQALVGLMDSRSKLLSAANSYYKYTRMLLPTSQSIENDLLGDGEKHFCKSRDWDTLQWCYEAIQERIEKHQSHKERFMEASVYAQRTADQFIRQIRRCDAPREHMEMRLFEVQRCKDTVRERQAFIFRLWMNTNAQLEHCRDATKIQLMVKEIVDWSDREMATCAKIKHTVDQLNKNRGDHRAKMEELLERCLEQWDLVKVERYETRKLLQETKHFMEGRLNELHVTEVKSGCSLAQIKFKNIWEMVMECEQVVRAALSLDEANIQRRKSEQEKLSLDRFSDSTIDEKLSAKECTADQDGENRKILEPMKELLKSEKDYIEDLRRCVDIYLYGYRTSGSMCPMAIRGKEREIFGNIEELYQFHCSVFLGELVAYAMNPEDVGYCFIEWMEKLKELYADYCLNKEENNYLICLPETIKMFNDIREQNGIELSHDLQSLVIKPVQRVTKYHILLKELLKHCAKNSKEIKNAYEIVLSIPKLANDRMHLKSFENSQGIAVGDFVMQDTFLVSEPKRYFKRERELQVFLFESNIVFTKKEELSSKKMGYVYKDSILLREVHVVEHIEGDITKFGLRKSAFPHQNDQNTTVLKANSEAVRISWKTDENSLTSAGGTNRSSRDSQSSITAVLSSSAVAIQATEDRNSAQSLENASCTATNNSVQRPHQQVVLRHEADTNGIVSFRGKPLTERSCPEVFEAAPHNSLSSLFPPTSSPLKTSSSMVDLLPSRFPTDVEDAGNETDDEKSGQAVEDTATIPCSSMVFTSIVEEDSEFYSANEPRNMPPPHSYSSQAQNQKRRNSTSNNNNNNNSNNLYKIFKTFRDQLERTKMTFRSSQTETEQQKERRRMANSRSFPISSSSMSSIHDYWKSLLQRESRSVQQRQERQWLVAEDFTADRPEQLCVISGQRVEMLSHQSDNGEFVRVTLLVNNNNNVSSSSGRTKSTGFVPRRILVAATASHTTPECGREHTLYEECSGIPLLYFEISILAKSAFLCYLVAFIGTGISVYGIASSGIVISFVLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1F6</accession>
    <name>A0A914I1F6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1F6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5995.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5995.t1"/>
        <property type="gene ID" value="Gr19_v10_g5995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5995.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39591" checksum="B31292CCBDF67230" modified="2023-02-22" version="1">MIFGNTFANLLQVIAVEGKSGSVVEKDFQSPLFHKIIAREVDVLDVEIRTLTGRQRAIAYFEGLPTFQRGYGYFLGVPRQKGAGVGAVLRNLWRYLRPMISAAKPYAANIAADLGKEGLETGARVLNQVSKGGDFLRICSRRKCQEGSSSGSSPTRTILAINKRTPFSLITITDIELTASGRTYPQYPYNLDYKNNNYARAYHDAQEHRGLACTTESNGLSYSMFKTAFCLYVFQMTNSQEDSPGFELIKEGCAAVIEKSPIHFALCILYLFGTAEAAAVGFYLFLRERRIRRQNGQPLIDKILFETVATRRFFMGTFPSDCLPECTRFPCSLIVNLSWQTRLSLVRDLGQVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1K3</accession>
    <name>A0A914I1K3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1K3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6034.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6034.t2"/>
        <property type="gene ID" value="Gr19_v10_g6034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6034.t2"/>
        </source>
    </evidence>
    <sequence length="504" mass="58858" checksum="DB84694432140C5C" modified="2023-02-22" version="1">MMAILLISHIHRIRNIRLNMEAVTMSRHNHHPSFDVWDQFILEESLLMGPNPEEVLLQEEDDYLVPNPFAIASLQDQLPNQYFDEFTPGHTVPKDKTESSSSHTVDSSNESNPDFMLAHKNLRILKIKLQEAEINHSLSPTTYRIQFINTKFANASKLEYRIQFINTKFANASKLKYRIQFINTKFANASKLEYRIQFINTKFTNASKLEYRIQFINTKFTNASKLEYRIQFINTKFANASKLECHIQFINTKFADASKLEYLIQFINTKFTNASKLEYLIQFINTKFTNASKLECRIQFINTKFANASESEFRIQFINTKFTNASKHEYSIQFINNEYCCIIASTRLGKLNNGSSVYRIHYDESVVFERFCVQHAEKQMYYYGVAVYRNHSEHSVATGCYLCSNQANEYGADFYRTQLDAYVGYKHPELNLQQIPENAANSSFGCATKTTFLEIFSQSIGEHFVVLLTEWQKRMPTNGPVQIEDTIFQNEFFKKHCEHLNKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2L5</accession>
    <name>A0A914I2L5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2L5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g604.t1">
        <property type="protein sequence ID" value="Gr19_v10_g604.t1"/>
        <property type="gene ID" value="Gr19_v10_g604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g604.t1"/>
        </source>
    </evidence>
    <sequence length="692" mass="77527" checksum="B5A923D69C1F459A" modified="2023-02-22" version="1">MLSKIPALDEFIPQLFSSLFIFAGVVSGGQPISGLPDDGGFDMPERSDGTKVGHLRHAFNILEPELAQSVWSKEGMKNPIRRTTTIPLNDRLDIGNTGELQQKEAAKPMKRMPRTAVAVASEYDMLNDDFLTEYDLLNLDFSLDDSPDSKKNAKEVEVPAKEFEWEEGEKRRRDGEENFPPKEWWDLEEPEASTTLATTTTTKRHALKGSKLFEVDGAERTSAEERSLVFGNSRKRESGRVRRGAGRWSGEEAIEREEVKFWPKLVPSSPQQQQQQPPPQLFVWADDVASDDDKTKKGPAKKEQIFRDLPAAVEVVSSLVEKTVDNRKQHNNAPQRQKSVEESEKAIKGRTWPTKQNGPPHILDRDSPGPTTSRRPSDWTLATTVGHSAQQSPPQSSDSQKQQENDRLFNSLPSIVIGEPEKQTDQTQSNQSTTEGTQNSKHNASEKQQNAKQNGQTEVTPADQSLQLPPGFSYLATVNSLPKDGRLLIGNRTYVIEKTLNQRHLFPRAKVPPPVHQPQQQRRRVSNDGEFSTLLPQLIDYPSPETTTILTTTNGSDEQGQRAIAINNTNARGESARRYAPRKKMFADVPQGTFADVPEQIGAIGVTNPTSRRLNTKKDILAHNLGLALSQIFGNFSVGHLPDTPEKKQQQPENEQQQLQQQMKPTPNGEENVEKVVSEPHRLTRVFEKKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2Q4</accession>
    <name>A0A914I2Q4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2Q4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10575.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10575.t1"/>
        <property type="gene ID" value="Gr19_v10_g10575"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6074.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6074.t1"/>
        <property type="gene ID" value="Gr19_v10_g6074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10575.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6074.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31218" checksum="8D6DDB6045286B5F" modified="2023-02-22" version="1">MSFLEELASFLKCSAVDVGARLRNSDEDRAKVMGAFAGIKMTTTYRDKNGFYHSFFLDDITTSGADVIPAYGRLRAPFNSVVAAHYFTRHRLTLVHPHCPCAVERLRPQPHDNDGEKRNHHHHHHHHHYHPFERFYPLELIRIDAGGSRAADSLLPALPSNSLDMCNNSTWRSADSNDSDDDHDDDDVDDVDEDEDAGLWFGESSHCREFFPPSKHGKRRSSSSTSTGSIVNLASCAGPPADAICVSFWRIDLDVKGKWARDSVWLDPYEIDKLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I399</accession>
    <name>A0A914I399_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I399"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6431.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6431.t1"/>
        <property type="gene ID" value="Gr19_v10_g6431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6431.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24940" checksum="BCB02581076A1ACB" modified="2023-02-22" version="1">MSDFLIEANIPTTLEPFVNKLIDSISDRVRKLIGNNLLRISTLLDPRFAYDETIFSKTNWALIEQDLIEFGKKVYKENEGRDDENDFQPLGFLDETDLSAGEKSDESVRYDIWKPKSPGTISVPSTLSGESQTNLTTRIQLQLASFKAFGRPSIDADIFNWWGSNGQQFPDLVVLARIAHSVPATSANLDELHLAPSAEPDPEKGDDDETIDVEDNEEDDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I480</accession>
    <name>A0A914I480_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I480"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7159.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7159.t1"/>
        <property type="gene ID" value="Gr19_v10_g7159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037478969" evidence="2">
        <location>
            <begin position="24"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7159.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27677" checksum="D4E4EECAFCDC7590" modified="2023-02-22" version="1">MASFSLLLIHFLRLLLLCQSVHSVVVHPRLRALNAAAISSEQLQQRPHHRHHHQRHIKTATATATAAEEEEEQEQTNNISRGRWYGEEAKQMLRQLDELRLRKAIQQQQKAVKLPKLSLFDKFISLFTEKPDDEGSKHDCFFSAFNCPVNPARSIPGVRRVRITAEERNKLLANRRHGTGFEGHGTGFEGHGTVFEGHGTVFEGHGTVFEGHGTDSEGHGTDFEGHGTNQTFPPPPPVCSFVVAVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I643</accession>
    <name>A0A914I643_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I643"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7247.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7247.t1"/>
        <property type="gene ID" value="Gr19_v10_g7247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017020">
        <property type="term" value="F:myosin phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF29">
        <property type="entry name" value="LD46604P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7247.t1"/>
        </source>
    </evidence>
    <sequence length="602" mass="67684" checksum="1476CEC74B705170" modified="2023-02-22" version="1">MFFISSHPNGLPPMARKEEEEEDSNSSISAFAHYSELSVVTIRTQSPCETDGDLSFNVRHLRESSIDGNGTPTIAFSSSLCRFVAVVVTRLPALIDELPEVEKMPAQQRIALARERREQQLRLCQQRDGQLPVPAPRRPRLRFSADIALLETTVRGEVQEVEIMLMDGVNPNSHNEDGLTPLHQCAIDNNERIVRLLLRFGADVNAKDTENWTPLHAAACCGYIDIVRLLIKHSADLLAVNADGNMPYDICDDEQTLDLIESEMAGQGITQEMIDERRQLPEREMLSDMKLLHQQGIPLDQRMPDESTYLHIAAANGFYDVAAFLLRCGVSPASRDKDSWMPIHAAASWNQPDLIELLCEYGADISAKTRNGETPLDLTEDPQTQLVIRTIAQTEARRKRIGHFGVRDSRRQSRKRKKFESPQAVPPAANTDFIQTARGAIRRQSLRDRSGMTLARLDSQREGSDLIRSWSKEDVSNEEMSAHPFGNGGPSTSHQPTTNQPRRDSPPKRMQKQTQQKQKQMSPDEWLKKLEAESGGFRDEEEEQQQAERDGLKGSMRKGVKAQKGNGVVRRDQQQHEANGMNLKGALGGQNRRRKKSCCCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6K0</accession>
    <name>A0A914I6K0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6K0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7970.t3">
        <property type="protein sequence ID" value="Gr19_v10_g7970.t3"/>
        <property type="gene ID" value="Gr19_v10_g7970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7970.t3"/>
        </source>
    </evidence>
    <sequence length="409" mass="46545" checksum="565D89E23B4F2169" modified="2023-02-22" version="1">MDYPRINERELKFPIPCGIIVSGPSSSGKTQLVLRLLSCADEMFAPPPKAIVWAYGEYSAQIPELERQGIIVHAGAPSDEMLNKLPKPFLIVYDDLMGEIDAKKLADLYTKKSHHNNFAVMFLTQNLFDKAMRVPRSNAQYIFLMRAPNDMLSIRNLATQIFPREQGFLIDAYKQACAEPYGKKQLIGQRVLENYEYLKTLGKTSSQKKIRHLLSSAGCEELLTPRDICFRDEKMANKLILLPIEHYRGLVAAREKIDDDVTEQTNFGFVKQQFEKAKRKRAANVSEKSAMYNQQLRRYLKLRKEVKDKPVKVQLSNGMRLMTKPPATGVQLKPGPEEVEETIVIGGSEADDDETATISTPKFSTPKEVEVGPEPRPSRKRDLKKQEIMAKEQQLLSIIKSDPKRARIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6Z1</accession>
    <name>A0A914I6Z1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6Z1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8074.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8074.t1"/>
        <property type="gene ID" value="Gr19_v10_g8074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8074.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35056" checksum="BEDC0C31E581433A" modified="2023-02-22" version="1">MNFYLLVMEAFYFLSDAQKAAQLSSNLKTVMIQRRKTNFSEQPFDTCYLQTAYEANDLRRRPLLRLAEIIKHDTVKLPRATEAELKQIGVLMSGITANVSEWIKNELENAWPEDIIGKAKSSIGLSDITDPDAYNSTARKIEARVSSMGVPGLIYQVLVSLDWDYLRNFYYGCRMPNYCTVVKGYHKINFAIFRHGEKNIYRNERSKEWYAKVNDSISAVIASNAKIDDLGSLVKEIEAACCSLLSDHLYNGFVLLHQSCFLAKYCDLSTGAAFSKDFGVDATACLFCSCSVPTSRTEQEQEQNRNRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I745</accession>
    <name>A0A914I745_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I745"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7368.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7368.t1"/>
        <property type="gene ID" value="Gr19_v10_g7368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00021">
        <property type="entry name" value="PRORICH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037823691" evidence="1">
        <location>
            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7368.t1"/>
        </source>
    </evidence>
    <sequence length="484" mass="49690" checksum="C83C9F9342643A18" modified="2023-02-22" version="1">MRFSEFLVYLVLLLPGPGAGQFGPLPFGGGVAGPGLRPNELNTVPRSGNGAAGDQLCHQYCLADGDQQPQPLQQQQPVQQFAIMPSPPPSQHSSARRQREERCCCCCCPQQQNAMPPPPPPPCCCLCCCPQQQQQAPPPPPSCCVICCCDEQKPPPPPPPPIILQPLPPPPPPPPQVCLLCCCEQQQAPPPLPLPAPPPPPQPVCCCPPCCCCPPPAPSQLMPPPPPPQAPCCCCPCCCGPQQSAPPPMPPPPPCPCCCCCPQQAPQMPPPMPPPPCPCCCCCQQQAAPPMPPPPPPQQAPCCCCPCCCCCTVQAQPVGGYGGMPPPPSGGFGGGFGGMPPPPSGGYGGGYGGMPMPPSGGYGGGFGGLPPPPAGGYGGGFGGPQIRPPMGGGGGCPCCQGGGAFGRRRRRKRWQNDAVAFGAKTRKASPFFSADPNDCRIISPDGCFGGGCAAIECVQKRSTALSTTAFGYERTRSAAFLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I816</accession>
    <name>A0A914I816_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7596.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7596.t1"/>
        <property type="gene ID" value="Gr19_v10_g7596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030160">
        <property type="term" value="F:synaptic receptor adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17091">
        <property type="entry name" value="FERM_F0_SHANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06746">
        <property type="entry name" value="PDZ_SHANK1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="494"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="1274"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="644"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="780"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="869"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="964"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1201"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="924"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1209"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1221"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7596.t1"/>
        </source>
    </evidence>
    <sequence length="1337" mass="142465" checksum="1106E37F32BE3B92" modified="2023-02-22" version="1">MIRSDAQRVAKMHFPPSSSSSAGSASPSLSLHTGTADDSLSTLGDQRHLANGTGMVATCSAAEGRADGTLNMQIFVPHLKIQKCLSVSLDELVWDIKRRLLHSLPQQLDKEFNYGLFLPPCDGRAGKFLLEDRHIRDYPFHDCVPYVELKFKKRVYKMLGLDEKALNAVQSRTNVRKMVEAVQGRNAAKIERLCAQGMDPNLHDAHGESLLTSAAGIEENRAVIVQLVGGGAHLDFRNAEGQTCMHKAAFLSVADNVRTLLELGASPNYRDLIGLTPLYYNMLNTDSNPEVAQMLLAEAAELDVVDMHGNSAMHQACKNGLAKHVELLIYYGADFNARNINGNTPLHVCAVNGRVDCAQVLLYRGADPSMLNRQGQNPVQVAQFVGTLAVAEVIQGHDPHNIVPFRESPLLNPRRRMSSRQSNSDHLLLRRRSLSHCSSSSTMASVHQHRFSGHQQPPASPSLSVVSSSVAGDYGTLRKDSVQQPGFEANVPRILVIPRGRNGFGFILRGAKDSESVGVPIECFRPSRANPALQFFEGIVPHGMAARAGLLAGDFLLEVNGVDVRTASHERVVKLIHQSGDPITLKVITVMEQSHYASTCGTLGRRNHSAPRHVSFVPPPPPQRDPSTTLSFGRTVGQATAQFCASELPPPPPPSSTAANPSALPHNNRALPPPSPPRPPSPPPSVPSSADQIRCASVKLGRASATRRISAVELEQLMVNQPQQQHGTPTKAMAMPCTTTAAAADGGPKKFTSVNEMKRRKQHNAQQQQIRSNGYGTINAMDGATTPLKNSNSSPDLHGTPEFRAVLRPKTPPPPPPAQKATTAISRQNGTVRVVNAAAPIAATAGPSGGRQPQQQPVYASTVLVQVHNDPSPTAHSAEMPSLPAHSNNTGTNVPAPPPPPPPNWLKQPLTQKQSVSSTEDNGSQSRASTSTSLASTQEKCASGNADCRGVSAEALQSVRLKPVKRDECMSSSGTSNSSSTPTSSTISQPSGKVVPPANFDSDLRSALAKRRSKVRVAEEKGEGEADKNGQDMATMSSSTCNTTTEDSSSNNNSGVTMVNRYNTGLSLRESVLENVAAGSGKGAHGCAGGVVKSMPNSHSPTGAFIGSKKDSGYTSSRTSLEPSEYGDTDHHHHQAMAAPALPVQHRVTVLSQQMEAAATAGQSSVALRGLSPPPATKLLTVPSMANSRRGTLLSENAVRIPPVDYDDQQPSTSCGQGTKSCSSDSGQGSSAGSEDSAEGIVIISNSVSPPPSVNDGPPPITTAMFRQKPVESWDFGNVAEWLASLELHGYASAFGQISGTDLLQFDRAQYTALGVTRIAHRQTMVQSLRSFVPRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I831</accession>
    <name>A0A914I831_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">R3H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I831"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8158.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8158.t2"/>
        <property type="gene ID" value="Gr19_v10_g8158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8158.t2"/>
        </source>
    </evidence>
    <sequence length="462" mass="51375" checksum="3092011E20F8D0A2" modified="2023-02-22" version="1">MDLRQASVTKRKHFLRSDAMVADEDAKLDTSRKKEVHEYRRSSIASNSKDSFCADSTGVDILRFIEETLHKNAKDRDFLLDTEQKLRELLLDESQSFLVFPSLSSYNRMLVHRAAAFFGLLHNVDQSGQKVVVTKLPGTKLPDIDFEQLIKHNDFFDSQSTRRNVHSFDETKERRYPMREFRSRFNTASSEGINGIDLARNRRARSFEIDNDWYAGFQRQHLALHRYSATIDYPGGGDGVSSNCSSSASSTAISAQMLPLHLSMLQATYANSSNEASMISPASAYSEPAAVQQQTVQCANHQSQISSRATAADAFPNAPNQFFTHPSYYPVAGYRQQTVPPFVFSHSSVLSPTAIAPNYPPAQPLLYYPTSSGAAFYQASASAYQNPFTQSLPLMEENGHNLLADQFGQIVLTENSDHQGEAVHSPLVEEGRQLTVEGTMATNTTGQTRQKHGIAIGPNDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8V0</accession>
    <name>A0A914I8V0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8V0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7702.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7702.t1"/>
        <property type="gene ID" value="Gr19_v10_g7702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7702.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="56635" checksum="B34BFD3E1ED3A7B3" modified="2023-02-22" version="1">MPRVCISDASARPNGLRSKECEEPHTEWMSIILGSWLAFVSSSQYSLYFTSLWPFMKTLDPSATEASFGVVIAAYSLAQIVAAPLLGFWANRIERLRPPLVLCNVLMFVGSSLYFVVEAFPTGGQTFMLICARFVAGSGAAQISTLRAYVSAASTLEDRSRATAFVTGGVAVGLSLGPAFQIAFSWLSYPGIALIPAVGLHLSMFNAPALFAACINIVNVVILEQFFHESYIGVLEKRRKQKSSAEEEKQQNSVPKLPPPDGVALRLCYLLRFTQQFIITNIETIGSAFAMLMFRWGPREVVYYESLSHIARGLTALFVYVAYIVFDLGKVAKDRPVCLASLLGLLLFHLLTFSWPFLPNDVPELMMLKPDNSSTGGKDQLATMIGCDRQEHPWCDGLKQVDVRLYYALIIVVIGSAFPLINVSMNTIFSAAVGPRLQAKQQSFLMVSGGMGRMLGPILIGVLFTYFGPRLIWIVECILIIFTGVLWVVFYKRLVPLKVPQELMRISKISGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9C4</accession>
    <name>A0A914I9C4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9C4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8706.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8706.t1"/>
        <property type="gene ID" value="Gr19_v10_g8706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="154"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="273"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8706.t1"/>
        </source>
    </evidence>
    <sequence length="504" mass="56978" checksum="1DD2E6F393AC2A39" modified="2023-02-22" version="1">MFCGLPSLAQAKTLPANNVRKSLTFPFVLKAELMMCGVTKTGTNVKVTAVKAEVGPDGDFVSVAEGETDSQNSTVLVPKPANSQIQRMLSSSGCNAATTNILLSMPFECSHELDTNALQALHHDDDEDHVHHAHSYFQKQKAREDGVKNNVKPYDLCLVCGDLASGVHFSVWSCNGCKTFFRRVVIENRTYSCKRNGNCRIDKDCRCACRACRFKKCITVGMDSTELNIERRRKRRKVETVNRASVSIEQIDDPLIRELVLKERQFLKLLTSTTAPIHPSIRDAFSKPSSFQQFEQHEQNQMKLGDQMNFSYWRAKILSTSIEWAKSFDDVARMSDEDKEAMAFHTPERFTDRIMFPDGLSGFRNFSANIIKERSGLIPTVVAVINNILVPIRRMQMSEVEYVLLLAIVLFDSECLSLSKSAISAINDKRAALLASLRRHLNKKLRNKMEAAVRMAELLLRISNVHKVAAFKRETLCTIETFNLMSPHPLTMEISKRYADMSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA97</accession>
    <name>A0A914IA97_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein-like 3 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IA97"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g874.t1">
        <property type="protein sequence ID" value="Gr19_v10_g874.t1"/>
        <property type="gene ID" value="Gr19_v10_g874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000493">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="8">
        <location>
            <begin position="150"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g874.t1"/>
        </source>
    </evidence>
    <sequence length="598" mass="66207" checksum="44A6813DB743334E" modified="2023-02-22" version="1">MAKYCLKKPSKRLTCKKKFKIQRKVREHSRKLRKLSKESERKKKSDKPVSVPNKCPFKEELLMEAEQKRAELKTLETERKARQKSAKTNCKKAQQTKRKAKTDDASIEALAKRATNDEDDYNANRVLAEMLPEKTNNADADSTKSVRSFAAEVRRTIENADIIIEVLDARDPFGSRSDQIEKLVIESGKRLVLLLNKIDLVPRENLLKWLAHLRQQLPTIAFKASTQEQNQKLGRYQTSNLSNTFSAKCIGADLVMKLLGNYCRNKDIKTSIRVGIVGFPNVGKSSVINSLKRRKCCQTGALPGLTRQLQEVELDKHIRLIDSPGVVLAPKGTLNDAAELSLRNAVRVDSLIDPISPVNAILRRCSIKTLMLHYGIPQFDDCDQFLALLSRRFGRLKKGGRPNLIASAKQVLKDWNSGKLRYYTEPPEQTCPGGENNSLENATEIVAAFSKEFDLDALEQDIRVLVDAIPQDAMAVDTPYDPTQSSALSIGAGDGNAEMETDQKHGGGHFVVMGGRGVVPPGEEGGSSSNNMDTTPGGHGTANARGTPLLPASLSLGEGNVQLNSAIRKAVKKRKKGQQKMAKRAEKLAGQLSERMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAN4</accession>
    <name>A0A914IAN4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAN4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8839.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8839.t1"/>
        <property type="gene ID" value="Gr19_v10_g8839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8839.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30278" checksum="19D67BA7A484921B" modified="2023-02-22" version="1">MIDFVVPDKGGSHFLGFVTLVNHRTSLLLLTLRRSVPEASLHLVRRFLRMEFSKALVFILFLALCAGGVIAQGDAASAASETAVQTQEPTQELVPETEPAAPVAASQVEESTAAPEATTQTPTITNKAMTTDTENEAKKTDNGSGFGKWWNRLKCLVFGFGPFRLGCPDKKEKDGSSGGDDETASLPHKSVHGMIAIIEESGESRQLDDEQMAVSLENEVAEEEEEQQQSEENDGDNENAPAGDVQIDGQLNVSATTIETATNEEGKTQTNIAQLDAEGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAP8</accession>
    <name>A0A914IAP8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9071.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9071.t1"/>
        <property type="gene ID" value="Gr19_v10_g9071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9071.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11165" checksum="FA54143E369E9DC0" modified="2023-02-22" version="1">MIKFCTIIYLLQGRVQEMRGLHLDLREEVAAVQWRDQFGDYDYVQRNDLSWQPTDLKLINDYGVPNPELMYPHFVTKCKRERSQEFIGVCGHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBF9</accession>
    <name>A0A914IBF9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBF9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9047.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9047.t1"/>
        <property type="gene ID" value="Gr19_v10_g9047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="17"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9047.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31038" checksum="B19E9C9DD307AA1A" modified="2023-02-22" version="1">MYPNLDLNPVGQAEFSMDLLKAVYRNRAEGNSAKNTVLSPLSAAIALAMAYAGARGQTAAEFGKVLAGDSSDSTLHNNFGKFLHEIASNLTNEELKKVNNLRPNGPPPEFKLSIANRVYLANTFNVLEQFKSVINTHYEGNFERLRFSNKAGLVNAIYFKANWLQPFSKKRTAKLTFFMTNGQESKLDMMQQTENEFIYVEQNNFKMLGMPYVGKKAQLFILLPNANDGLENLLNELKGAKLMELAQNSASTKVEVIVPIFKIESSRAAIAWHYKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC69</accession>
    <name>A0A914IC69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted SPRY domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IC69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9257.t3">
        <property type="protein sequence ID" value="Gr19_v10_g9257.t3"/>
        <property type="gene ID" value="Gr19_v10_g9257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="38"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9257.t3"/>
        </source>
    </evidence>
    <sequence length="251" mass="27998" checksum="48A533971E356EC9" modified="2023-02-22" version="1">MQQKATFKKPFLLLVPQNAHHSLLGLWLLDRRLYSAGDGESDASPPKTLPSNTNTEQNQWDADTCNKGLTLSVSTLSEPEQLPGSRLIVKYNEYNYESRSVRAEQPITKSKSDMFYYEVKILALALTGIISIGVGPKQMPLNKEIGMLKGTYAYGSGRKAFIWGHELAGCRHANGRPYIFEGIPEFRADDVIGCGVNLKNRKIFYTKNGVLLETPVLLVDSVAGLFPWVTLYWIGDAIKANFGPNFVYKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC99</accession>
    <name>A0A914IC99_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IC99"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9285.t4">
        <property type="protein sequence ID" value="Gr19_v10_g9285.t4"/>
        <property type="gene ID" value="Gr19_v10_g9285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9285.t4"/>
        </source>
    </evidence>
    <sequence length="260" mass="28837" checksum="E65511F5811522AF" modified="2023-02-22" version="1">MSTTTTTGGGSVEIGVPIRIEGVQPQQQHQQQHGQDGGAVPKHQQRQQHKQPPSVVERLRQLEAEMDAEAAAGAFRLPDDRELTVRLADFLADRYPDADLQLTVSSVRRTITTKQQYETETPGMVGLPLEQLQELQRKLMAKISAQPFEHAKSAEKGEEIEEKQEEWARRGPEDVQQSESVEEGVGPTDEAGTIVSKKRMHVLATSQSQVQGLDGFQPQHSPSGIPVLQQHRTEDGIRVVNRNQGRPTTPTSTSIPIRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICD2</accession>
    <name>A0A914ICD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
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    <sequence length="1150" mass="130321" checksum="BB3FA0E4DD6FE80F" modified="2023-02-22" version="1">MNPLEQRLLQLDKLLAEAQLNRTTIFRRFRDSLVEFEADFTRAHSEASSIVEAARMLLSETGNICGVPIAKMDELANGQTEDITDSAMDGKKEEGKKNGLEESDGQKEEISEEEENELEEANGKEEDDGAMEGHKEEGTTIGREEADGQAEEFSDGGVGDVKKGEKKVSGGSVGDQKEEWTKIELEETNGQKEEVFDGAMDGQKEEGKTNGLEEGDGQAEEFFGGAMEEQKEEGKKNGLEESDGQKEEADGQKEEADGQKEEADGQKEEADAQKEEISGGEKNGLGEADGQKEEFSDGAMEEQKEEGKKHELEEADGQKEEISDGSMDGEKEEGTKDGAEDQQVAAVRVELSGIELVRSTLFRNIIVAYTGLSRDEREHLSALVHKLGGQVWSAVDQKFTHLIADKCDPKSDKYNHARRSKLPVVLPLWINAAVKAKDLETLNAVLTNKFINAHKTPIFAECEISVSGFLGVERVELGRLCTHLITATNSGQKYLRAREWGTVKVVSSRWLYESVEVGYRLPEDDFVFDKKEDDQLSTDSYVTTASQQQSVGKKHKKLTILFIATNEGVRMDSLYLARIILDRCNSLLASRSRYTSKEEFARVVLQTLLGDSSIDLLLLKPHFDSVHADALNRLNALIGFESTVFMTIYVNDVLFDEFIELFSRHCIRSPATIDEANESVYMWLLADYLQYLLPVDEQKLNLLKNSTWLSGPLASLPTSAVTSPRRLLRPEVLAQCAPLEHVSLRSGAFKTLYPRLLQFVGTMLSHVASLSNWPSVAQFQVLRVILGHYITFLLSETEDNEFTSLKLLLLRKPLFVDILQNFLDRLLRNWPLDQSYCLLIEIWRTLVHHKLLNRCFDEKYKLFVQVSSQYYVDLIETQIQRMLTTDCKQLVEAPVLDYAVENIFRCEPILGVFEQRNLPAIDYLRALCRKLEDYRNGIQKKLDMCQKSRQRSVWSRLLQLIFAFTYTAPVNMNLLNAHIYSDTQRSFESTTDAMNRTSNLSLLNPAIPDHETDKWTKMLFLTPHGRLQVVNRQAKFDYAKYTRQISDAFPSMGYWDIRPIANFLHQLSIRWTDAWLVRYLRQHGRDSIISRFASAALLSGPSPPRFVPVFARYVPQHPSRLKLYKLASTANLIYAILSILLIFILFKMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICQ6</accession>
    <name>A0A914ICQ6_GLORO</name>
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        <submittedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
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            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="Gr19_v10_g9630"/>
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    </dbReference>
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            <end position="245"/>
        </location>
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            <begin position="1"/>
            <end position="10"/>
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            <begin position="22"/>
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            <begin position="161"/>
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        </location>
    </feature>
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            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9630.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="35162" checksum="836C5C34D0D15E0B" modified="2023-02-22" version="1">MSGRPNQLNKWQPRRSNRIEAQKNTANGKDTTPPTHRHSSLPPQPPNAFAASSPPPQSITAAAAAVAADTPSNTITAAAAAAAAAASATDTHCTPQSPSAVAPTPSITASLIRGEEEMPVDEAGNGDKQQQQQQDGSLLQPEQQPQASHDRTRKAAAVTAKAKRRQAKNWNKKRRIPIAVSASAKYVPKSVQLNPRTQSYEVESILASFERNGRKAYYVNWLGYRGAQSWTLSEDTDATEFIANFCNKSSVEGCLDAFLGNEISESLAAELRNNPKYLEVCQLFGIGDHLHITEFNVTFCPNTAIALQKKAIDALPKFIRDCMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICR5</accession>
    <name>A0A914ICR5_GLORO</name>
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        <submittedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Nematoda</taxon>
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            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Si:ch211-266d19.4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
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        </location>
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        <location>
            <begin position="221"/>
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        </location>
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        <location>
            <begin position="249"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9411.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="32038" checksum="5C474C178803950C" modified="2023-02-22" version="1">MVDELHEERGVRKEDEEMPDEEEETKGEEEKELRAEEKEEMPDEEKEESTDEEKEESTDEEKEESTDEEKEESTDEEKEESTDEEKEEMPDEEKEESTDEEKEESTDEEKEEMPDEEEKESTKKHLRTHTGVGKKFKCAICGHQSAHACNLKLHMRTHTGVKPFKCMFCDHQSAQEGNLKEHMRTHTGEKPFECTKCGHRFSQSSGLKQHMLTHTVKVKKFKCTECVHRSARAAELKLHMRTHTGEKPFKCAICDHRSAQAGNLKQHMRIAHPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID76</accession>
    <name>A0A914ID76_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID76"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9131.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9131.t1"/>
        <property type="gene ID" value="Gr19_v10_g9131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.50">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016133">
        <property type="entry name" value="Insect_cyst_antifreeze_prot"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51156">
        <property type="entry name" value="Insect cysteine-rich antifreeze protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9131.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28641" checksum="37B1AF4C89F1CD53" modified="2023-02-22" version="1">MEFLWADQLLWADQLLWADQFLWADRLYGLISCYGQINCYGLIKCYGLINSYGLINCYGLINCYGLINSYGLINCYGLINCYGLINCYGLINCYGLISCYGLINFFVLINSYGLINCFGLISGYGLIKCYGLINSYGLINCYGLINCYGLINSYGLINCYGLINCYGLISCYGLINCYGLISCYGLINFFGLINSYGLINCFGLINSYGLINCYGLINCYGLISCYGQINCYGLIKCYGLINCYGLINCYGLINSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDF4</accession>
    <name>A0A914IDF4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9826.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9826.t1"/>
        <property type="gene ID" value="Gr19_v10_g9826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="61"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9826.t1"/>
        </source>
    </evidence>
    <sequence length="478" mass="54494" checksum="A0664A3F3DFE9B1E" modified="2023-02-22" version="1">MINRFIRNFLYGQHIICKVQQIQTVRVTFLHQCAKNVCPAAVLSCGARMPSSSSSSNRPSHSSELLDAYRNKRTANLQLADLGKDAVAFAQDPLGSRFIQQKLGRANPTEKAQLVDALRGHVLTLSQQVYGSHVIEKALESVDKASQIEIINELLAQVLPLSLHKFGSRVIECVLEHCTEQQKRPVLEQLRDIVPTLIMDKYGCHVIQHVIEYGRPEDRERIVHRLHENVPTLVTDQYGSYVIEHVIEHGRPEDRERIVRCLHENVPTLVTDQYGCYVIEHVIAHGLPEDRERIVRSLHENVTSLSVHECGYRVVRRLLEHCTEQQKRPVLEQLRDIVPTLIMDKYGCFVIQHVIEHGLPEDRERIVRSLQGDILKTHYKSICSIIEKCLSFGTTKQKNALIDQVCADDGTGKTPLLQMMKQQFAADVVLKMVDGADSAHRDKMVFAIEEHIPALLKRQQSLKEKGGRRSRRQKEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF74</accession>
    <name>A0A914IF74_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IF74"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9676.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9676.t1"/>
        <property type="gene ID" value="Gr19_v10_g9676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9676.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7839" checksum="3AE1BD411CAFBF0B" modified="2023-02-22" version="1">MQNCKTCLAHTVHHSTQLTKIYKNAKDTKELLIKGTRIRTPSQRPPQPPALTTRPSQRQIPSQSANEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IHL9</accession>
    <name>A0A914IHL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IHL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9997.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9997.t1"/>
        <property type="gene ID" value="Gr19_v10_g9997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9997.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14970" checksum="94666FF916A83E84" modified="2023-02-22" version="1">MYNGYFVTILSLSFVFSINSDRSTRHGGSNNNNNNNNNSYNNRTWSSSSEEEDEAGEMFFFRLIDFLFGHGSGTASSTAQRKNISSVPFMTTNNSLPPVTNVRVGRSAEVGRMRNQTRQIGQGSSASSADGSPEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPU8</accession>
    <name>A0A914GPU8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPU8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1006.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1006.t1"/>
        <property type="gene ID" value="Gr19_v10_g1006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1006.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="37272" checksum="41377E1A42A40BE3" modified="2023-02-22" version="1">MSDNASQEEQQQQMEKIFICADVCLDAFGFLNPFNLGLRMALINRRFDKMVDKHFKRSAEPPMPILEEPFPDKVIGFKRLEISYFDQTVMEFLQRIRRLFDSSGTNVWFDTSYCQNRSWEIIRRIWPLVNDNIRGLRLLETVQLDNLRRISPAILRNCANLRSINAIGFFPEFPGDDTDDSSSSQALAKWLFTPRGDGLPKLLYCSFTRARMDRLKRSFANALEPANFILRFEIDKNDRRFVPFELKNNWTGERLTTLRLLDKGLLVRCQIRREEDKWAKWEEEAIQWKWQRQQQNIAISFEDIDIGDGLNENEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPX3</accession>
    <name>A0A914GPX3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione synthetase</fullName>
            <ecNumber evidence="4">6.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914GPX3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1008.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1008.t1"/>
        <property type="gene ID" value="Gr19_v10_g1008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="418"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1008.t1"/>
        </source>
    </evidence>
    <sequence length="696" mass="78691" checksum="F704B62245F3BF0A" modified="2023-02-22" version="1">MMNKVFSNDSNALFEDDQNIDEAFDQVFKQIHEEENKMPFGPLLKLWEKVAQSEKAIIDETNVSLRNEGLQSSIESEMKALKKAESLLDALKKRRLELVQQSKEKQGAILSSLDQNQELFRVPDDVENNKMMLQEILREYANELQEMRTRLKAKKNKLNLIDMHVFKYHVKAGFKIFYFSQMSPSTNTGVVTPNYVADVVEMNENDDNHRQQLSLLVEDALDWAHCFGLVLRTADHKDRSDVCQAAPFALFPSPFPRGLFDEALAVQKALNLLYFRASWDLDFLTEAHRHVIPSDAFTRNMMDILVDVHREGVKQTVTLLTQRADYMCHVASTDVGDEAGRQQKFELKQIEVNNIAVSMGGLAQHATVLHRRMLQKAGKVPSIGGTVLPENRPIDTLTEGIYIAWCQFVKTFGDPSALLLVVVGDVNQNQFDQRFVEYELELKSTGQMKIVRLTLTQCAERLKLDTNDFTLRLDSRAVAVVYFRAGYAPEDYPTQTEWEARRTIERSTAIKCPWIGLQVANTKKVQQVLDTPGAVERFFKEPNDAATVAAIRHVFAGMWGLERDDDATNRVIQDAIANPDRYVLKPQLEGGGGNYFGEEIVTKLRAFTSHERAAHILMEKIRPLVVKNYLVRPFQPSQLVNVVSELGIYGCLVGDGQGLSVCHNHAHGHILRTKSEHVNEGGVAVGAAVIDTPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPX7</accession>
    <name>A0A914GPX7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Long-chain-fatty-acid--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GPX7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10084.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10084.t1"/>
        <property type="gene ID" value="Gr19_v10_g10084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF24">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="113"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="547"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10084.t1"/>
        </source>
    </evidence>
    <sequence length="709" mass="78747" checksum="2FE09530699E5B99" modified="2023-02-22" version="1">MGISQLFDQLRQRCLPYAKREQHQHHVVVGCGMLLLLLAIGGMESAVPLARTALALAGILCVMFVTSQADFIYRSWLTLDRDLTGLFLLIRIRLDMWRRMRENKGIHQLFVDVVNANPDGLCIIDMTSGKQYTFREFNALANRFANAFWTKGYRSGDVVALFMENSAEFVAAWIGLAKIGVVTAWINSNLRMDSLVHCLRVSECKAILCTDTLLSTLEAARQADAVGGLDALRVYALGALNAQFAHDGTHLDTEPPVEEPVPNFRSILCFIFTSGTTGMPKPARIKHLRYYSMALGIAQSFGVRADDRLYISMPLYHTAAGIIGIGQVLLRGSSCVIRARFSASNFWRDCVQHECTISQYIGEICRYLLAQPHCEAEQRHHVRLLFGNGLRTEIWREFVERFKVRVGEVYGSTEGTSNLVNVDGKEGACGFLPISPITKLVHPVRLVKVDENGEIVRRPNGLAIACRPGQTGAMVSTIRPNNPLLVFDGYLNQAETNKKVVHNVIRKGDSAFLTGDILHWDRLGYLYFRIRTGDTFRFKGENVSTAEVEAVLLPLKCIIDAVVYGVRVPELDGSVGMAALVKSDEAGTDDEFLGQLSTRLRANLPAYAIPRFIRICSAVDRTATFKLIKTNLQRIGLARHCVAPAATAAGDRLFLMDPCSKEYRPLEECLRQRLNGDDELLSPEGNKMTTAPEAMEAAADQQLISRVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRB3</accession>
    <name>A0A914GRB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1058.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1058.t1"/>
        <property type="gene ID" value="Gr19_v10_g1058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1058.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="47765" checksum="20C12115B0CBA891" modified="2023-02-22" version="1">MQKVTDKDFKFAEPFFRYMCKLRVNIDALNTELAEAKHQADIENDQVLSRFYAKEVEPFEIDHPNEKFNIISRIYLTQYITICRFFLQKFLTINSENEMHFGKIMKILQSNQKVLDLVRYEKKLEQFDAILKSNKILIQKKLEYFGEECVKTKIYKLSYTNDQYLHSIESIESKLNNLDCIWLQDDASEGARHFWTVDKRPNVRQTLWVVRHAERCDGVDKEWGKGLDALARQDPPLSPGGIEQSKELGKWFEKLPISKVFASPFKRTLETSTLLLGERRRVHVNVEPGLGEFLKPCAVQLGFMQMPDLHKAFPLTDPNYLPVYSKKALEAIVAEAVSNKKEEERKCHFMVEQTLRHILEQNQKAEHIVLVSHRDTIGHIHKLLGGEWAVVGQATQFVVEYSGNVSTFPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRQ9</accession>
    <name>A0A914GRQ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRICHOS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRQ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10692.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10692.t1"/>
        <property type="gene ID" value="Gr19_v10_g10692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10692.t1"/>
        </source>
    </evidence>
    <sequence length="799" mass="86643" checksum="1A33C9F3B57AEFA2" modified="2023-02-22" version="1">MVLKRAINVSCPSQVNNLNCLLSEVWAMSCASPSSQSSTIFTNSTTHLPAIRHEPQQQFPSTAMLNNNRNSSSSKSVHHPPSIRPQQHKHSRSSSTLTVCEVAKASERADSGRKKPEMGAVAGLPPPVYRSQVVSAAAPYCWSSTTSSSPDSLAALGKRRSSWSNLVQASEISHLPSPSVPISALPSVHHAPYRSAPGGGSRPPSYGEIVAAGNCQNIRHSHTTASRQTSNASSSARSGEVFAGSKGSFFRFVGPPAPFPAAAGRSASAQSSTAGGRVSAAFLPRRPLQPQNSTEPNNLPKTKKKDRMQDLRELWAKTSCKLCCLVLLITLIGLVVAVAILAETFVAPKSADFAWLPPDQFRAGGQPNRVAMRAGELGEQVRFELTGAPPFKSNFVTVFDFKTNKVAHLDRSLRSASAGRQSVCFVLDLDRQQAPNSDELQRAAKAGAEKNRQLHGWEEDWHFMPNPVSGAAKLFQPDILECQGARWIELIRTPIDQKGQRCSECFDFCLPDWGVERDAIRNEQYLNVLRRMCFHLFVPEWRTFAQSFSTQQNQHDFEEFYRRQQQQQMANPNQQQQQQVGAVSGGGTMETKWVALQTPQTPQNQHLQQPPNVSAFFPSISSGGQSVLSGLGQVGSGIGQLGQGVGQHLFGTAGAVPSRQGQQMPPFGANGVQSPQSIVPQLSVHSQFSPSELNGPASPQPQQQQFPAHTPPLSSLWNEWSNGGGLLSPPVESTGGVGAVSGGQPPHQQQTVGGQQQSQPTFFGQSPQQQQLAEVEQHHQQQLTPSVQAQRQQVWVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRY1</accession>
    <name>A0A914GRY1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRY1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10622.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10622.t1"/>
        <property type="gene ID" value="Gr19_v10_g10622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="32"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10622.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17162" checksum="764751C48F21ACFD" modified="2023-02-22" version="1">MLLSSRPFCAIIHVMSTEAEKAQKAKPGGDTIFGKIIRKEVPATILYEDEEVLAFKDLNPEAPVHFLVIPKKAITSMSACEDQDQAVLGKLMLTAKNVAKDQGLADGFRVVINDGRNGCQSVYHLHLHVLGGRQLGWPPGTSGTFLHTLLGKFGYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSS4</accession>
    <name>A0A914GSS4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSS4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10884.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10884.t1"/>
        <property type="gene ID" value="Gr19_v10_g10884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10884.t1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49517" checksum="C570FAB5987764BD" modified="2023-02-22" version="1">MFLTPSHTSLHGHIEYTFMECKEAVIMMLKKRQANYCITSKSRKKQILRGATTNPSKPQANNNPIESQPKIKAEPHEEQFDGKWHDESALKGIVKVEHEPHYGAVKVEGKDKIKHEFEFEWWGEENAVFKEQLEDRVKEEDQHGQAPNTSDHKKIGDDDENWSQDEDNSTPSADELDQNNSKEAKDLSDQNNSTDQNESVDEQQNNSTESNNNPIESQPKIKVEPHEEQFDGKLHDESALKGIVKVEHEPHYGAVKVEGTDKIKHEFEFEWWGEENAVFKEQLEDRVKEEDQHGQAPNSSDHKKIGDDDENWSQDDDNSAPSADDLDQDNSKKHLSDQNNSTDQDGRSGGHTYTASNYDYNANLSYTSNVPYSAHRTDSANLPYSAHRTDSTNLPYSAHRTDSAYRTDSTYLSDSPYTSDPAHTTYSTYSAHTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTM1</accession>
    <name>A0A914GTM1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTM1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11149.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11149.t1"/>
        <property type="gene ID" value="Gr19_v10_g11149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11149.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7753" checksum="09E6710DFD3A8590" modified="2023-02-22" version="1">MFGETREATNDGWKGREWRIWRSDRWNRGKEKHRKSISRSGAPEAFFCRSGALRALPLSCRSAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTP5</accession>
    <name>A0A914GTP5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopyruvate hydratase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTP5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10668.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10668.t1"/>
        <property type="gene ID" value="Gr19_v10_g10668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10668.t1"/>
        </source>
    </evidence>
    <sequence length="433" mass="46519" checksum="698567CDD1FAA840" modified="2023-02-22" version="1">MNYLQQIGGGMGNQQQQQTAHRPLNPTAAAVSQNMSPNVAPSPQQQQMTAYQMSMYHHQAAGGTPFSPHNMYSQQMMTPQMVSQQQQQFLPNAPATPATPQMSQSIGTPVSMQNMQQPGSVQLQQPGSVGMVATPAAPYSVAGPHSNQPAQQTTMSQQQQQLPSAQSMGGVSTQTEFDPIGTAKSLILKDLRRAIVNLNQCAERALDTCSNPNQQQSLQTAERFHEDGSRKAASTAVVSTGGPHSNLGLMSSSGGPHSNLGLMNPHSVQNPLSVQNPQSVQNPQSVAGIAPGSVKSSSDEQQHQQRLGGGKDGAAEEELTVAEQYAEARDQFMNACDNIERNMQLILEVNRQQGKLYNQQANSAVAWVEVPSMLNVPTTTLPHVLHGYTELMNADKQAITGNIDSLNNLLMRLGGGEGQPSMEQKVEPMDHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTS0</accession>
    <name>A0A914GTS0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10333.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10333.t1"/>
        <property type="gene ID" value="Gr19_v10_g10333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10333.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10520" checksum="73C61E57F591DEF9" modified="2023-02-22" version="1">MTKSPEELGKIKADDGRNEAEDEAKNAADKKNRKEFGGPAGPEPTRYGDWERKGRVRVNRVSPVASRHSRLRASRVWPIASGQSRLSPTNKKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU17</accession>
    <name>A0A914GU17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GU17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11230.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11230.t1"/>
        <property type="gene ID" value="Gr19_v10_g11230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002544">
        <property type="entry name" value="FMRFamid-related_peptide-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01581">
        <property type="entry name" value="FARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11230.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19819" checksum="3750987DC3949D22" modified="2023-02-22" version="1">MSRQRPPPIRRIVSRCSLTSPIARRRYLPWPVPTAIPRALFLFLPLLFISSSVSAQSYESAELRILEEKGGKRMFYQPWSYMKRTPSTEPIIRFEKRSGDDQFMEGFKPLSSADPFRFFKRSIVVPLMRFGRRPAERAAPLIRFGKRAQIRTANAVPLIRFGRSSEEERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX45</accession>
    <name>A0A914GX45_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10"/>
    <dbReference type="AlphaFoldDB" id="A0A914GX45"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11201.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11201.t1"/>
        <property type="gene ID" value="Gr19_v10_g11201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000171">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11201.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25565" checksum="33DE76B1CE3EFEE1" modified="2023-02-22" version="1">MTASKIKAIICPSILNTDLSDLANECRKLVAAGADYLHLDVMDGHFVPNLTFGHALIGCLRKQLGNDVNFDVHMMVTNPEEWLDPMHKAGVDQYTFHWEAANAFGGDEAVSALIDRVKSKGLRCGLSIKPKTPVEELLKFGAKIDIALIMTVEPGFGGQKFMQEQIEKVRRIRKAYPQLDIQVDGGVDLDNIGECAKAGANVIVSGTAIIHSVGPPETMQKMRQIVENALASGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXF4</accession>
    <name>A0A914GXF4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11650.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11650.t1"/>
        <property type="gene ID" value="Gr19_v10_g11650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
        <property type="term" value="C:amphisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="337"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="385"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11650.t1"/>
        </source>
    </evidence>
    <sequence length="601" mass="66849" checksum="9AFF24F77EEB61DA" modified="2023-02-22" version="1">MSNSTTESTNGDTTADQCKTLNKNDEHLTPTFAVSLDPSAEELRLLRLARIADLEHPKDMAKAEADINQLKGKIATNQLKKEKLEGEVNGIKHNIKLAEELLRARIAKLECAKDIAQLEEEVNGIKGQQKATADHFSHLNATIDDLQSKVAAEQEHQKLADANETLQNKLVKLEEDQNKQQQNIDELQKSIAALTVGHQTTIGHLEHVQKNDREEMGQKMDALLKSVEEHQKLVNADATLQNKLVKLKEDQNKQQQNIAALTDGQQKLHTTIGGLEHAQKNDREEMGQKMDALLKSVEVQQRNIDELHKSVAVLTAGQQKNSEPTVAASASDVKQRHPNITCDLCDGGVVGIRYKCFVCPDFDLCEPCEKTGVHGEHALCRLATVGTPKPCFVRLQSGPSLPSPNRWNNAACHTGLTLFEPNRLIVQRNGNGCEEVLPNPFITISRAKSSSVFAEVQISNQLGIFYYELTILKNRGTIHFGLATRQMPLDKRVGQFEGSYAYEEDGTFWGHPIEGCRRTDNGIPFIYKPKLWAFNTGDIVGCGLKFATRQIFYTKNGLRLDNADLFATSVDLFPCVTLCRPGDKIEANFGPNFIFNMADVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYZ0</accession>
    <name>A0A914GYZ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYZ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12631.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12631.t1"/>
        <property type="gene ID" value="Gr19_v10_g12631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12631.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13161" checksum="E53BAC6F290EBDB9" modified="2023-02-22" version="1">MANSGGVSNENDSQIKRHRRLPLELQCEAFSALPFQHGRRLLLLLVCHPIATNCVALVRKQKKKFENRWDPTACHDDTTNLFVDDFADDLFPFVMLAHPGDKIEANFGPNFKFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ81</accession>
    <name>A0A914GZ81_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ81"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1255.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1255.t1"/>
        <property type="gene ID" value="Gr19_v10_g1255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18362">
        <property type="entry name" value="BTB_POZ_KCTD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000005">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958:SF29">
        <property type="entry name" value="INSOMNIAC, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1255.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38943" checksum="962A9053526FE2A6" modified="2023-02-22" version="1">MNEAATMELPLAATVIVGDGQLPQYNWTTVDESRGTADSNGTNGVDNRLDATDDGGEGVSARTAATTMSNSTKQTTAGTNVVGGGSKSWIKLNVGGKMFLTTRQTLCRESGSFLARLSQEDHSLPSEKDESSSYLIDRDSDYFSAVLNYLRHGKMVLDHGLSEEGLREEAEFYNLPKLISLCNERIAEREKNKKTGTKHVYRVLQCHEDELTNVISAMSDGWKFEQLVPIGHSLHASESGQPEYLCVVSREYPVAAGAAQLNELSSDRAQFLQKKAMNEAGSHNDESPSKGRASCDFIYCLSRLVCKSWTQRKRDYKSTQKWGDGGERARTVVEHNDTIKDQPMGTKIKGGVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZY3</accession>
    <name>A0A914GZY3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12914.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12914.t1"/>
        <property type="gene ID" value="Gr19_v10_g12914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12914.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22507" checksum="1810F9E7B687CFFF" modified="2023-02-22" version="1">MLGETSSPHRTCTFITTTEFAKFLPPDSSRHKMLFSKPCSISASHPLMVLLPMLFIVVAMLSSNSVSATGMPPKMECCQPAMMSCCAAPAMQSCGCGRRKKREAVQPHIKGNETPCPQTEWRQLMQNAIVPLDDIESVNSVQKALMRRFPDNKFLVMCALAGDEIRRPADSKQMLPNEVHLSSSGNGYCNVVSERIWCQAAAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0P8</accession>
    <name>A0A914H0P8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hormone-sensitive lipase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0P8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13096.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13096.t2"/>
        <property type="gene ID" value="Gr19_v10_g13096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010468">
        <property type="entry name" value="HSL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06350">
        <property type="entry name" value="HSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hormone-sensitive lipase N-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="452"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="917"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13096.t2"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113256" checksum="E8F2CC8E10BC3491" modified="2023-02-22" version="1">MQSLYSSRRPSSMPSTLNRRRVEPSASQTVGESTVGESNRRRVNRRRVKPSASQPSASQTVGESTVGESNRRRVNRRRVDHRRVGVGELNCSRWPPCKRFYRRAMKSPVINKFSNYTPSAKRPLASKLSVQRNAVFDLLKQLAIDNYVYFRQNNSSSVYGNRVSECCDELSASVDLIRDIIRKLQVASQKCDYDEDTPGNGFRSLVCITDIVLLHLVSVLRICSESRGVMMFRLAHHCKEIEAYSAILRFLVLAYQQVVLMLNRLDGDSLFPPLEGDYQQYNILFKGIESLDGSCFYGRPLGFQFFPSVTRIFRVIGLVLATYSLSWENGSAALSSLINSGRMLLNPEQRAKRIIKVTREADINFCRGFWNLSELPTAKLFCPTMSICEVCEIKPMGPLPLETVDGGLIHIPEPSAHTGVRPVSIKILSFSHRIGISPPNVLNCLPLSPFLVIHCHGGGYVATSSKSHETYLRSWAKSLNCPIVSIDYSLAPENPFPRPTEEVLYAYAWILNNPEKFGWTGSRICMVGDSAGGNLIVSVNLKLVELGVKRLPDGLIPIYTPFLFQYLPSPSRVLSFMDPLLHMGVVIRCAAAYTGSYSDEELDKNCSFHIQSTTAGGNGHRSLQDYVDQVQRAQRDNILDFTQGSQSIVSLINLSLFNKTPMDKSPTVEENSVPVKRERTDGSDVEMDEVPCSAKLERTDPKVPASLTMSRDVVERLMDEDGAEEEEEVANETIQTVRVNSDPFHICLSSGNFDSCLIDYLQMHPITKSSVHNFPESSDTQKSNECSRVDFDDVPPAEDEVFDEMSATTGSFSSACFASIGNAVDRSPIHSLKNAAVEGGEFSEMATSERFELGTHSDVQQKTTVEEQMPLTQPNDWLDSPMEPLGYNDKKKLSRAVTLSPKKAAKLNQMDAENHQSHFTELLKLKLPRDHLMSPMYAPKKLLAKMPPMCFVACHLDPLLDDTIAFAKRVRDSGGRVKSVDLLDNLPHGFLNFAPMSSDCRDGANLCCNAFLFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H247</accession>
    <name>A0A914H247_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H247"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13184.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13184.t2"/>
        <property type="gene ID" value="Gr19_v10_g13184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13184.t2"/>
        </source>
    </evidence>
    <sequence length="117" mass="13627" checksum="8E67536B98F7B0C0" modified="2023-02-22" version="1">MLLLVTHQTSLYLLGLFDLLTLFMSLCLLYGIFSFERAFLKIHWRFDFFALGFNVVAFFLFVFALNSEGPETWTWKNVLLAVAFASQIPLQLWAISVVKACYDFYVLLYVFVTLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2Z9</accession>
    <name>A0A914H2Z9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TauD/TfdA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2Z9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1318.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1318.t1"/>
        <property type="gene ID" value="Gr19_v10_g1318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="9">
        <location>
            <begin position="137"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1318.t1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48841" checksum="8DBD48F584B1E73D" modified="2023-02-22" version="1">MRFSAERQIRAFSNLVPQRSIAVTFKDGSDGLFPYVWLRDCSLDSKTYTITPAMKGRLHFMRNFDVNVQPLDISLDKNGNCLIIKWPENVISRYEQKWLKSRCPANEKVRLLRRKFYLGLECVRNWNRKQIEGRNFRFSCEEFLNNDRVLHDFLLTVCTDGIALLEGTEQNPNNSQLFEKIVQRIGFLQRNHFGEIFEVIPKANASNMAYAGAEELPYHTDFPSLSDPPQLQMLHMANRAECGGGLSMFVDGFHIAQLMAQKYPEHFQLLSTIPLEFVEEGFDVHKLMDGSEERFDYDLVARHKTIKLDGHRVVQIQFGNVMRSWFIDVGDPLLIQRIYDALKMFTELCYAPENQLIFPLKSGDSVLWANTRLLHARTGYAVVGEAARERRVIGCYFGWDAVKSRVRMLRDVLKLAPNQNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H397</accession>
    <name>A0A914H397_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H397"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13597.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13597.t1"/>
        <property type="gene ID" value="Gr19_v10_g13597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="99"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="570"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="866"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="868"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13597.t1"/>
        </source>
    </evidence>
    <sequence length="942" mass="106386" checksum="43FA5EFE625F815A" modified="2023-02-22" version="1">MESTRSLRPRPSTSALALAASKKGPPKPKPTKTKNCVQKGQVQPQDRKEPKIPLLEAKELLHTSNLPNELLMREVECKEIRQFMLKCIKPKSKQCIDASSKVLYICGVPGTGKTVSVLQAQKDLASKKSVPKFVFVNINALELSEPRQLFIAIYREVHKNMTGAKKKISARNAQYFLNEYFTKKVYQRKPIVVLVDEVDMLHTRREDVLYTVFNWASLEQSRFCVVAISNTLDLAEKFSQRIRSRMGTERLIFQPYEWEQIEAILRHRLDACPLAAIDGAIKLASKKVAAFSGDFRHALELLQNAIDIALEECEKQGDDPTKQCLEAKHVTAAISEDPCSIRADFVRSLSAHELFLFRALIYVLDTSGLDVTTFAPVFRRYRQLWFADANADTNADTNADADSDSDPDPDSDSYGIGPLEMEDAFVHMEDMASMHLVCLASDETGELHRSVRLGFSVAEAKDSEGCPTTPTTTNISSRPVQVQQNSKTMSNNNTSLRTHSAHRALRLRLRWSVDVALLMNDELGKELWWATMETCKLPDELLERKEECEEIRKFMLNCIERKSEQCSDASSKVLYICGVPGTGKTVSVLQVQKDLASKKSVPKFDFVNINALELSEPRDLFIAVYREVHKNETETKKKISARKAQNFLNKYFLKEDPQRKPIVVLVDEVDMLHTKREEVLYAVFNWASLEQSRFCVVAISNTLDLAERKFSQRIRSRMGTKRLIFQPYEWEQIGAIIRQRLDTCPLAAVKDKAIELASKRVAFISGDLRHALELLRDAIDIALEECEKKGDDPTKQCLKSEHVTAAILEDPCSIRADFVRTLSAHELFLFRALIYVLDTSGLDVTTFAPVFRRYRQLWFADANADTNADADSDSDPDPDPDSDSYAIGPLEMEDAFVQMEDMASMHLVCLASDEAGELHRSVQLGFSVAEAKDCLREAGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3I7</accession>
    <name>A0A914H3I7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metalloendopeptidase</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5 6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914H3I7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13662.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13662.t1"/>
        <property type="gene ID" value="Gr19_v10_g13662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038155728" description="Metalloendopeptidase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="10">
        <location>
            <begin position="345"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="9">
        <location>
            <begin position="554"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="8">
        <location>
            <begin position="615"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="8">
        <location>
            <begin position="660"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13662.t1"/>
        </source>
    </evidence>
    <sequence length="703" mass="77074" checksum="5238F97DB1BF9372" modified="2023-02-22" version="1">MATNALLVLAACLMLLPPLLVANGGGLLGLLLEEDNGGSAVHGRNRLHGGELLAELVGALGKGGGEDKKNGGTKADGNGTAKKGGHEHGKPLVDELAKNGFEEQLIDGVPLRFYAPDPNSDIPPHVLRRVMRFCSKHPTHDKCKNHPDWIIDEDVLPALPGLTDKLLEEDVPDELVKALPVAKKLEAKSKQMLVNRCVGGLCKKQKPEYLNQRASLAELESVTFKSLFPDIPIESIDLAIEVRQRRVYEVKKALLKQAGLEEYIEPADDGVFQNDILLTEAQANAMLTQIEHAGENVRVIPDGPPELFPIEDAPSTDTGGAFIDGGGRPALFPPGHSKRTKRAGNSLFFEKSPNEKWPIAQPIQFVLDNSFGASEKSTVRAATREIQSKTCISFVEVAVSPPGPHIKYINNKRINICGLSLVGRTLPLNLIHLNFAPCVDANMMGVVVHETLHALGLGHEQVRPDRDDFITILWHNINPQDISSKFKHTSYGIPYDFSSVMHYDNTFSARRYGLKTMTAKVNPAVNDAKMGWLDGLAQSDVNVLNRMYCTAPDCIDKKVECGTLATKDKCYNDGTRDAWMVENCRKSCSFCKPTIGAAAQVSSSEEDLEEDLDEDLEPDLDELQEIFSSFSKEVIRDVLEANGGNRELAVDALIEMAKPRPEPDLDELQEIFPSLSKEVIREVLEANGGNRELAVKALIKMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3Y2</accession>
    <name>A0A914H3Y2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3Y2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13420.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13420.t1"/>
        <property type="gene ID" value="Gr19_v10_g13420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11418">
        <property type="entry name" value="bHLH_TS_ASCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13420.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="37350" checksum="4ED928C92A71D285" modified="2023-02-22" version="1">MSSGHHLPGIHYLHSNRHQQPSSSLSLSSSSSSSSAVLRLLSSPSKDNKPKENKAKARKNGKKGAFGSKFLSSPSKIRQRGRGGAGLKFGGKKPHQVARRNERERKRVEGINNGFETLASKLSVSCSAYFDKKLTKAQTLKAAIFYIRHLEGTLSSEKAMDGSSIKGTAEEDFHRQCLAIAAEKGEETTDDQGEDGIKEMEEDGGDVQHNHHNDRPPEAGIHHCLSFSSSDHLSSISSSDHLSSFSSSDHLSSISSSDHLSSFSSSDHLSSFSSSDYLPSISSASSSSFSPSYCYPPPPYPHHHHPLSFHSLPSPVFSYSSSAPLQSLQSYRTTHYFSKNEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3Z6</accession>
    <name>A0A914H3Z6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3Z6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13631.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13631.t1"/>
        <property type="gene ID" value="Gr19_v10_g13631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF282">
        <property type="entry name" value="CUTICLE COLLAGEN SQT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13631.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="29396" checksum="C7365E8B012BFEF9" modified="2023-02-22" version="1">MKVHIVPLVASTLSGISLLISLALIVSIYNDVHQSWHQFDRDIDAFRAQTDELWSRIMALGQSKRRLSRAIGRARSGGPSEARSSRPAGRAPGTPSGAQPPGVAPALQATSVVHGEGCDTSTSAGCMTGPANACPPGLPGPSGVPGKPGPEGIPGVDGLNGKEAEDVSPANQYGHLLLLPGRLARQHRPSAPGQPGEAGPLGPQGEKGRDVEKPIGRPGPRGPRGPIGPEGPAGEKGADAPQGKEGPGGELGTPGPQGVLGTRGAPGDEGPTGRPGPAAEYCPCPQQASAGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H407</accession>
    <name>A0A914H407_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H407"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13786.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13786.t1"/>
        <property type="gene ID" value="Gr19_v10_g13786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13786.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24730" checksum="93692BA9563DFA3F" modified="2023-02-22" version="1">MDYPRINERELKFPIPCGIIVSGPSSSGKTQLVLRLLSCAYEMFEPPPKAIVWAYGEYSAQIPELERQGIIVHAGAPSDEMLNKLPKPFLIVYDDLMGEIDAKKLADLYTKKSHHNNFAVMFLTQNLFDKAMRVPRSNAQYIFLMRAPNDMLSIRNLATQIFPREQGFLIDAYKQACAEPYGYLLVTLHANTNNILRLRTNIFPEDDEKIIFVSKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4D7</accession>
    <name>A0A914H4D7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g13538.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13538.t2"/>
        <property type="gene ID" value="Gr19_v10_g13538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056282">
        <property type="entry name" value="MROH2B-like_N_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF0">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23221">
        <property type="entry name" value="HEAT_MROH2B_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MROH2B-like N-terminal HEAT-repeats" evidence="5">
        <location>
            <begin position="307"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="4">
        <location>
            <begin position="548"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="4">
        <location>
            <begin position="923"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="3">
        <location>
            <begin position="1394"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="6">
        <location>
            <begin position="1971"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1676"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1786"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1686"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1786"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1832"/>
            <end position="1842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13538.t2"/>
        </source>
    </evidence>
    <sequence length="2250" mass="247350" checksum="35F043A2737FB106" modified="2023-02-22" version="1">MAESMEEMDRATDVDREMDKSGFRRAQFDLFKHNFLESFDESGYATLEHLTLDATLKKEVVNMARRLQKARISLNSLPDRAAIEPESSEYSVRNLKLPEYSREEVEALLGRAESESDQQGQSGDKHLTAPYGSSIGQGQKGGDSVEWLCQSNEEYEKRIEALLGAGELLMNEWHEIKQYLQNNRPGKSERKAMVQNLQDLITALFDCSFASQQRASPALNSSIARALASLGAKQSNLFLSAVHTFLLQRGTKVMVEEESAIAKRHASRNKIQFGEDEPYPSLNRLAEKDKAFIFRSLATVLAEGHLLDNCNDQLEQQVLLIVNLSTQEMSMAKSDVNSDSLASATKEVLVTLGGKNGRFINQVMDALLNKFQPGSSTPPHKFVILTMAEIAQKNACGFVPFLHDILARIDALLGHVKVDSMRSAFCQSICAFAESVNESVVSVSSPQLQNHTLFGDDMASVASDSIPTAGEVNTTGSDAVENFADQFEKTYDVVLGWTGSAKDSKCRADAAECVGTLCLMIAKERVLKDLKKLDSLFRSLHKKAGSPEEQLAIVRGIANFLQTCCPDETLPIDHYLNDLFELLFPHVCVVTEQRVSIEDDHLSPNMLQIKIRNEVFRSFQVSSCRSADKEIYFILHKMQSPNENVKLGAINLLRHLLNSADVQMKENRSLITMGLKPFLVDEGATVRVKMSLCQLCVSLADNEYVQADEGGQQVMHFLLNNLIPPRYDPYTKRPIQPPPPAPTGGVGEGQSLQQQLHVQCAQALSTIANTSKSAHALLWPLLLEYVCLEHYAPVIGDIFKCLRILCAREKQAGRELDFNFGENPRLPGPVPVMSRLLVCMNGAPLNAFLNTRATEAFRLFVELANWFHEKFVDAELIPKLSTQMLAILEDFCGGALDFPKSPPASSSPPTGAKDEYVHTEFRSIRAQRWQAAVLEMLCTLIEAVDDQEWRESLAAIQAKQLGLFSSTMQEASSATLQPSHDKAFLMRCLGCTLARVHAPQFITEHLSLLFRQTQHGVTPERVGCAQAMGHCAASLDHADLVLTELENIAKWEHTKKGISSGVGGAGASGGSSSSGGGILSYIRDYSFGRTVDAEVLNLRSTLVLSYGYVVFYCPPEGLILRLQQTVLPFLRQYTATAKETIVREAHLETLNLIALSVHSNRIRDYKFEPRYECLTYVKTYLNEEKSPEQLNSWIRLLGAKAAASLVLLEPPLSDNEFFELANSLILNIFSICRERSGLKTLDPHCALGFPHFTPLRQGAWTFQRAITDQFYGTVHPVPSDDDAKPTEGDRKGPIKANVIASASKMAQPSKGSEQQRRGGNSNKLSLSTNCPANGKRVVDNGKIDDDEASTVMEATIMQCRNAIGNLVQRRPFVEPTLVKLLKIIHPFYGSEKDHERARAVDFTVLILHIYSENAADCSLGVAKEFTPLSHLLGRLCPRLCDSLGSVRLFALRAIWLAFKLSLLHRGHSPLDTDLVNSTLFDVGEFVDAHFGAVNEGRLDSNKCRAVISAMAKEVERWLPQNQVQMYISALFKMLSDRQSNVSSAAAQLLTCIISVRGHLLQLEAEVLFNKLLDHLGLAQTTMIQTYSELLNGFNLFSAHHQYLAIHVLLKQPLPYKQMMTEVWMMMARDHVQFVVAIDYIVDLLRANASSNYAIDAQQQQYAINKLRNVSIGQEVTESSSGGAGSEAGSRSGAQSPVFSPAVRPHFEFVDLGGGTFIKVVSSEACALLSALTELIKKGEPEEALLERVPLLLATLLQVLAALVDTQYSSAQKHAVVVLEKDAGVASGTSQTTTTSSMASTTTTSSATSAATTAPTAASVAQSSPAKKGGGKSQNPSTSSSFSPPLPVIVTAELTRLSTVPANLVASALKALLSRIGAVNVVERMNSERAWTNILNPQHFTQAIASFARAFLDFRPHFVGSLMAIEAARLESGPHVANEAERISATAVLSALITKSPHENGRFNPDLFVTCFQALEKALRDPNLTVRKLAIHGLGHTDHLRGAECEELLAQYVPRSIDAALAGLDDHGDRQDQLACESIAALDRLVAVSVPSLLVRVLPQLLLKVRPCFEKENAALRASAFSLFAGLGSSVGNCETFRESLQHNMMSIVLHLNDEEETVQRCCAKVLHTCASLLNSEHAAALVEQQLVDGKVPLSYADFLRQFGMILPLSFPDRLNTYALDCNNYFRSQSARIRQNAAMLIGFMLTALTPELRGTLSKDLIFSGLEQLLRDPDEDVRVQTVSAIALLYAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4S5</accession>
    <name>A0A914H4S5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4S5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14158.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14158.t1"/>
        <property type="gene ID" value="Gr19_v10_g14158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037253608" evidence="1">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14158.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15500" checksum="7D7B8BB0A2FCA082" modified="2023-02-22" version="1">MLLNLLAVYAVALMTTLYMPVQSAYTYQKMDELMPELRQYLGRTHLGTLKARQFNDDDNAFQMFTKRTAEQQIRERKSNNLRNLMRIGKRNVPFVDNFAREDEVGVGAIGPVYYLPSDFLQAYRPQSVWLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4T7</accession>
    <name>A0A914H4T7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H4T7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13245.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13245.t2"/>
        <property type="gene ID" value="Gr19_v10_g13245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005330">
        <property type="term" value="F:dopamine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051583">
        <property type="term" value="P:dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015874">
        <property type="term" value="P:norepinephrine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF320">
        <property type="entry name" value="SODIUM-DEPENDENT NORADRENALINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 15" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="607"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13245.t2"/>
        </source>
    </evidence>
    <sequence length="757" mass="84635" checksum="E149FD57ED350F00" modified="2023-02-22" version="1">MPRFVQLQEENREDGGGQLDGNGRKQLASLASANRDVSPFGTVSFRHFGHFFVPSPEMANKTKQQQQKVENSVSLTTFKRRQRQMASSSSIVFDQHPSRIQITHKNFMSIVDFSPTTPPNSAKFPIDSQLVKDSPPKYSKVLGTKVPVISPFLCSRQRFNEKVAKASTELVLNTGGEDRGDAGGAERETWERKIDFLLSVVGFAVDLANVWRFPYLCFKNGGGAFLLPYTMMVFLAGIPLFYMELALGQFHRKGAITTWGRICPLFKGIGYCVIMTAFYTDFFYNVIIAFALHYFYASFSTQLPWTSCAGKHNSPACYEPSWSDESQKSVGRPVSAAEEYFYKHFLGLHAEGEATPHVTQSIGQLGAINWEIVVCLLIVYIICYFSLWKGIKMSGKVVWFTAIFPYVVLFCLLIRGVTLPGSEKGIEYYLRPNLEKLKDPNVWQDAATQVFFSLGPGFGVLMAYSSYNEFHNNVYFDALLTSTINCGTSFLAGFVIFSVLGYMSCKSGKAIHDVAQEGPGLVFVVYPEALATMPGATVWSLVFFLMLLTLGLDSSFGGSEAIITGLSDEFPAIKRNRELFVALLFSFYMIIGLTMCTKGGMLVMEWLIVYGTTWGLLIAVFCETMVISFCYGIRRFCDDIRQMLGFEPGIYWRICWTVGAPLFLIAMILSSFINLQPLQFYSNSICFSPLANSVGIVFALSSVSAIPLMALWQLRNAKGRTFGEKLRFLLTPADDQLVHHPETRALRMDSEHGDVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4U3</accession>
    <name>A0A914H4U3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4U3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13997.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13997.t2"/>
        <property type="gene ID" value="Gr19_v10_g13997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="2">
        <location>
            <begin position="519"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13997.t2"/>
        </source>
    </evidence>
    <sequence length="1081" mass="123054" checksum="6A2E0563EA29C46A" modified="2023-02-22" version="1">MEFNRPKRMLTLGGLEPPTFCVFYLTDGENGVKSIPCRATGQCMPKMDNKTYGLSFRLHSQGGHCDDGLLICYPGMLMRHYSTGIGSYAFKVKGTFQVGNEKNSSVSRKCANLLGKVGITDGQHWRGMNVYTKPINATELNPTRQTFLETSLTPNVYELGTISPFSIHLAIVGKFGGNGEFLQDHTELWMFILDLLPSMEQENVKLFIARNCNCTMEAWLIQPTDSSDPKEPELPTAGSNNCPIKKIDFSIDLTGLELPTKIVIKAITDDKLNNITVELLHGDEMDKDGNVLMKITIGTTDDLTVILPGTTPNVIENFRLPRKSHIMRLEIYLYEYCYGLALNGTETAGLFWPKHWWNRKKVKSIKLNGQMLLLEDPRVLNLTDNEFKNISLPPVELSLPINLTGSNGDAMDKNGNVLMEFTITPNDLKVFLPGMSPIVTESHKLYDERREMLLEISIFNYCYSIIINRWAGRLFWPKDWWNRKEVTSIKLNGQMVLREDPRVEYNNIGRPYMLKLELPYFSPIWNFLEGSTFLFRVQLLNPSRGFKITFSNNSTFDGITNQTAFVVQVVELKRVELGVYYGGRAHPEQANRKDLSFTPGDVYEFFISVSNRFYGIRLNGENLFENYSNSMPFCDIEYVRVEGDAVVLDKPEMPKPPVKIDKVYVHALNNTLLNYGDKIIIFGKTHNKSGTVNTSKTRTKDAQEFVNNDVAVLNFEINSYKPIICSHHLHNEEAAGLNTETVTSGKHQIFIRPYAETALEILMAKDGFYGRKSGVYWYKLCPYYNPKNINISTMPIPPWAIDHITVNGSTFDNRQILVVKAISNHGWRLNFESGKNVFDVPWKCLNFTQVIKKEGVDSVNYAVFVNITLEEGLKQDSEVRINLFNEALEFHDLFGTTVLRVTLRNNTLSFNSFSNQNKTWSEPTQNNSFTFEMDLKMLEYNDVTPTMNLIQQFHTDTLTPMMDPKNSSYSLNSTIDQLHNSTFMKTTDLENRLPPNLYFKIDVHQTDGKAEFAVTLNGQDKDVDQKVLKYQCPANVYVPDIQYITVEHDNITLAAGSEVKVSCSSEVKCTNNDRPYCDITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H564</accession>
    <name>A0A914H564_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H564"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14260.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14260.t1"/>
        <property type="gene ID" value="Gr19_v10_g14260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14260.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28310" checksum="5794D70E751BF5B1" modified="2023-02-22" version="1">MSEIWKCFDKCSTEEAKCKICSKKLSRKDGSTKGLWKHLESAHKREFQDLKGIDEQKMHQESILNFTVPKKNSVEEAEEQIARIMIRIKSGVSNSFYAITSDGWSQPTKSPQLQSVTIHWIDNKFGRNDNVLASFPMDEFRHTGEILAEKITNCLETHGLNTEKLVCCVRDDATNMQSATRMMDKDSFQCCAHFLNLVANLDELHLAPSAEPDPEKGDDDETIDVEDNEEDDFELPAYDPTIYPVAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H598</accession>
    <name>A0A914H598_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H598"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13949.t3">
        <property type="protein sequence ID" value="Gr19_v10_g13949.t3"/>
        <property type="gene ID" value="Gr19_v10_g13949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WH2" evidence="8">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13949.t3"/>
        </source>
    </evidence>
    <sequence length="861" mass="97345" checksum="92B58AF6C319D565" modified="2023-02-22" version="1">MANQTQFQQLVPFVLKENAVGDTLSFSRKFVSSSLTCFSSTGRTSISLSRHAEQIFSEIHRETLKIDHRANTLFLRVERLAQKLSQSQGTNNLKGVMDQVTLEEAAMRKAFKSFNIIDQHSLDRQTLPQSLLEQYQNCDAPPQLNQLNPYREDEKEALCYYTDPSYFFELWRNEVLKECDGGLIEKKRAGRSSTSPSRQRRRQQQDIPQHQQNPSFAHHVSSRSSDYSRFAPQFGHQNKSQQNRARHGFDPGHFSTSIAADVLHFPAEYQTPQSLLLSGLLHQPPPPGMSMVTANTENWSHTQQQCDRNNRQICVTDQNAEMPRRIPWPLHSLLHNDHDEPSTHCLLLLSGSKVEFKPSNGSTETSELKTQQSPNQQPDDSAVEQQPQQQIQSMQQIPPSVCISSVPPPPPPPPPVNFSAKIRKPSSTGAQDNRSLLLIQIQEGVKLKRVRQQEELAEKRAVATSNDVAAILRKRMEHCLGDSDSSSNLSRNVPKFDWISINANFMNSAATMTQKLMSAAINPQRLLRSLLPSLREELAASLTNDLRGAEAKISREYIQQLFDYTMGEGKFARSGLALRTYLALDPSPSDVQFHNAVKVSLAIEMLQTFFLIEDDIMDGATRRRGKPCRHQLPGVGLKAINDGLLLDCGIDNVVRRTLPSHPKMYAILHDFSEAKQKTVIGQLLDTNTELDEFSWSRYSAIVESKTSHYSYFLPLIVGYHLADCTPTSPTKLRQIAYRIGDLFQAQDDFLDCFGDPEITGKSNLTDLAEGKCTWVTCALVDKLSKEAPEKLNLFRENFGKKSVQQLKLARQILLQEGIGQKFEHYQTELVEDIRSELAQLPAEPIRNILHQTLDDIVNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5P2</accession>
    <name>A0A914H5P2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14415.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14415.t1"/>
        <property type="gene ID" value="Gr19_v10_g14415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="2467"/>
            <end position="2670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2404"/>
            <end position="2464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2443"/>
            <end position="2464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14415.t1"/>
        </source>
    </evidence>
    <sequence length="2946" mass="332423" checksum="A26873FBF2099FBD" modified="2023-02-22" version="1">MPRLMYCSPERRPSLTTAIPSCLPSDIKLSVFNKAIPGRNWRADCNRANDLLGMIAKGNKTHVSHLRNLVRDIFVYKWEADREAMHQRGQGIAIPAATRNGWTEGDAWAGIELPAKDPVAFEKWLEKRKPIINTTHPVGYAPIAANTKTVPEQRPDVIVSGLDKLAYHVETRGAKIFLRNYANEKKAIPKTKEAKPVGYAPIAARNSAVLPPDKPMNCHDRRVKPLIHHEWQVITRKTVPARRTLSLVSPCPPTPTPTLRTVWDTLTPKKKPKPISRVEETQSPPLRNTNIMPPRHVSALPYSIVSTEAKLLKKSVFNHLPVTGAVTQMVVFNQPFPPSSSPADVVYRDMFYLSVEKPGKTCSRTLNVSKPKNRRILLVPFPMKMDIFHHPVLHRCWPADLVRRDMLLSHIQNGDKTSTRLLLQLVRDICYKKWLYNDDSTLQFCTNSYKLRGGATPEDSSAQNQHDFLLSRFHSKENRPIAFAALTTLFGTAVVSRRAYSRWWEQFSMGDFVYRTRGNSCDIMSTPVSSRSTHRFANKRTAKQREMSNTDSLQSTSADPDLPLEKLRILSEESFDLNIIQHDALQPEVNEAQVYEDVTAVSDFIGPGQQDMLHDLGIETSGLLSNDAIKNCKQKLGIGCFETSCYCSEALCAKDLHADELEEKLCSNGGLCLQCSAPHPGFCNLCKKLFCLTDDGFPPDKVFLPCCSTYCHHHCWYEPEPRQSCPRLCGSPWKGVQDINYIPACDVKEPAQQRRIAKPRGCFGGRAVRPNQRIPPSSAVSGMFSQSTLDSVLMPPPSLAPRRSQRESRSTSRFSSEMWSSQHEVFEPITNQCATPHSKHFGVGCGACSAKHLPVYYDSLAEPCTCPFCGALCLHSEGTGPTAFSKCCAKGRVDLLFRFNDLQNRPGELMALLYNHDTGIVRMRDALFKNALAYNSHLSFGQIQLQLSTDKRAYDKRIIKCNNMMQFAVWDFNPPSSSLPALHGQLFTIPPVDAQTRLSEISTDHNLSPELMQFLFDVLRRYHPYADLYQTAAETFRQLPQQEQVNLRMLLVDSTPHGEERVFSDDVVRPAPIIAPADLQNVQQIHPGRLGVQTVDGSRLVAQFYLDDGSNVVPSNPYDVVLTGRFGSGKRHMKWSNRNIDPALFPLLFSRGQCGFERGLPLRLREGEHVDSHLLLRDAQQNVVPETDELGEEAEFLGPTNERVYNRRDKVSFAQWFRYMSQIRGANWRNPHWLWDWGTIAQLYTLTFNNRAEAQKVQYMKRKQGQRLQGPIGRVYMTDEHFRGSRQFYQREYANCMTICREFGPPDLLVTFTMSPDCPELQAMLGTDAGGKQQQWFDRPDLVCRLFVDKLQELYKDLTERGVLGPVRAWFGALEHQFRGLPHVHTAIILDWDRMRNMGKIQTPADYIDEYICAEIPPNPTGRTKEAAQQRALHKTITTKNIHTCSTKHCLQDGKCRKHFPKPFEYDNVHSENAYPRYRRRPPPPSLQEAQMNPELYGREIQYKDQRGKTIRKDNSHVVAFSPFLSSKYVAHINVEFVAGDGCIKYLCKYMMKGADMAFVQVTDGNTGQSALNYDEMHQIRLARYISSMEAYLQQLGTPLIRRSHQVDELDVHGPQGHRIAVQQGFEDEEEQRNAFCEAAQAEEERRNAGEERVTQLTAYFAFNEQCQDDALHLTYATAFKKLWYDAAKKEWKLYVQENRAGHKLCRLKTVSPSNLELLVLAIRQLLLHVQDPTSWVHLRTVDGTIFPTFVDAARARNLMSDMTIWLNTIKEAFNTKKSIKQRIRWLAVFLATANLTNGAALLEEIMKDANKWLVSTKVGKAPPEQQLQYVLRALEWFLLANGIRPDTECREDGTYETACEHIGLPRPEGIHMTADQLIQLTFFRNNVIIDNIDPELLPDQLDCRQRVEDYYRIKYFEDPQPNTEQHQLIEDVYKGCVDAQQVISGQQASFTPGLSRLFMVTGEGGAGKTFSYNKIIARAKASGLNFLPMATTGIAADLLYEGQTVHKRLCRAKHVDSSTALNVDYESNFAHMLRSIHGMIIDEISMQHRDVLEYVDRLLRSVAPKRLANIPFAGKVVVLGGDWKQLAPVIPGGGHLDQKNASVKSSTLFKHFTTIRLTANHRLQAGQGHYRNFLMRVGSGLLNNANLRIKLPACMVEPDRDALINFVFPPEILKDPIAHWAELEGRAILCPLNRETLELNNIIMDRLPTRERLYTGFTTPVSDETTVDVGLQNNAADVNYENLSRLTPPGLPEHHLRVKVGAVMMIITNISLEEGLCNGTRVQVVELFTHIIRCRILTGTHRGNAHDLHVARFMFGGDPRAPHEGLLRCERIQFPLRPGSVMTINKAQGQTLSHVGILLDQSQCFSHGQLYVALSRVRQAENIKVCTKRPDRLVKNIVMTDLLDPVDHEPPTPADTTIADDPFPHQPPAENEPTINHEHTTRPSPSLSTPATRTSRQSSASPVTLNLAQAVTRDLLRKLVVVKGDITNQHAFMIVNAANNILEKGGGVDDAIHRACSFELTLLRLELQDHLEAFNGALPAGTVVVTPAYGDLRDHIEYIAHAVAPVVLGSTPTTDDITALKNCYSNALDHLLATEIPPERPQPRTIAFPCISTGAKGFSRATAANLAFESVLNWLAEDLERAAEVPEIHFVMFANEDYLLYKELVNKTQRQIVGSRTSTPRSSQTTQRNSLPIASDCNMPLCYPSTSAQQQNAVRCVNNVGLGDCFYRAITISLFGSDSEAISDLLRVAVSRQLTLILQNANYFPRLQYASHNAFLEHLQLALLDVEAPQWFDQNLEAYANYIAMPFRKNGGWAQLDDAYMVAILLRRTVAIVHPNATRDQLQAHAAQWNDSKQYPQIIDVYFPDGIARRSQTNMPLEDLQQFTLICDNGAGQQFQRQVTNPIVLWYNGLNHFETIVLPPSGAQSSEGSVFIEHFDETIPPAFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5P5</accession>
    <name>A0A914H5P5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5P5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13451.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13451.t1"/>
        <property type="gene ID" value="Gr19_v10_g13451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13451.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="28647" checksum="FBB0C739881805A8" modified="2023-02-22" version="1">MSEPSSSNHNHTHNSSVSNGNKDRMNQSQIWKCFEKMTDYEAAKCRLCTSMLSFKRASTKGLWDHLKCKHKPEYLVLKQNEELLAPSNPDEFKAPKIKKKKLEPKNDICADNDNSLVSGVDTPQTELIRVRIQSNENRADAAPMNGGAERMGSIDSQPCTSVMVNHILVWSSICSQSAQSTFIMCSLLDGDHHHFGTKSGASATLTYVLQKLGVKPEPSGCFSTTCPVNLVLDELSGLGYRAIGMVNKRADEVLWTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H644</accession>
    <name>A0A914H644_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H644"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14348.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14348.t1"/>
        <property type="gene ID" value="Gr19_v10_g14348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548118" evidence="1">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14348.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24448" checksum="CDC88D794B49F6AB" modified="2023-02-22" version="1">MRPFLFLAAVCLLLADASPRKKPKLEKGPSSAANAESTHVTVQNSLGLTLQNRWDSAACNEDLTLIEPERLIVQYNGNYYGHRCSVRAEQTIPKDGIFYYEVTILEKESAVHIGLATEQAYSNCDNFWGHKVDFHRKRRPLGEKPEFEENDVIGCGMDLATRQIIYTRDGERLKTLFVDSAAELYPCVTLLNSRSTIKANFGPNFKYNIHADAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H669</accession>
    <name>A0A914H669_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H669"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13599.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13599.t1"/>
        <property type="gene ID" value="Gr19_v10_g13599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13599.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38154" checksum="D1BAB61C6ABB6CE4" modified="2023-02-22" version="1">MSDNPPQQRRTRELNVCDDVWLSIFPFLGPAELAVVMALLSDRYDVLVDLHFRTRKWELGKLEVQRSEDGTGAQIVKWNDDGSLRHLAMPQGPPPAKLVGFNRILISYIDGTVIAFLRHIRRLFNAGITLHLDILDSEHRSWDIFVQEIWPLMSANISGMIFYCSLHGLRNRISPTVLCDCANLRAIRSHFAVPQWPADDRREASDGQAMTKWIHTPREDGLPKTIQNFGAKFPDNVVNELRETFLNASTAVSYIIVIDLDILSWAYDGDSDDYRPFEHQNGRTRERLTFRHEKRWTEWKKAAVDRIKKSMIGVFIKDDNIGSLSPAAGSSNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7L7</accession>
    <name>A0A914H7L7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7L7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14566.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14566.t1"/>
        <property type="gene ID" value="Gr19_v10_g14566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037138025" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14566.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9119" checksum="97D1F01841F05ACA" modified="2023-02-22" version="1">MSRPTLMAMAVLFIGVLLAMFNPSMEVCPPSYLGICEWRNCVEEKPAGSHMMICLPEERPENCLQESWEQLTELNELEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7Q2</accession>
    <name>A0A914H7Q2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7Q2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13991.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13991.t1"/>
        <property type="gene ID" value="Gr19_v10_g13991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036688298" evidence="2">
        <location>
            <begin position="28"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="3">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="3">
        <location>
            <begin position="238"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="3">
        <location>
            <begin position="313"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13991.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43108" checksum="5B5D65A6EFF93764" modified="2023-02-22" version="1">MNSSNLIVLITNFSLLLLITVITFGDGMPQNASVADQTVNEAATSSDQQDGFNVTIADQIMHDAATSTSNQQVVSNATIEVVELITDTVNGTDQQQQAEEAGLTGPQPAVAGGELANEGNVPLVSAALADDQNAKNESGSNSSDTSSGNVADTTKFIPHGDNDCWTDDNVNETPRWIANGEQIERGIVWYECREGKLVTIGCIDENGKRLTLNGTYQSGRYRMQCVPFGENARRQMIGCVPDGQLDKTYLPGEIWVDNVKQIWWQCVLENAWPGGCFDVASNKSLIVGEAIDSNFTTYECQHKHMDGFHMVPVGCIFDGIRYSVGLYWQDDDFVFFCKLQRDDSGSDATSTTCIDCILRNQRLFDDEHIFQNEHAVKCEKRLAPEGYTPCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8W8</accession>
    <name>A0A914H8W8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8W8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14887.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14887.t1"/>
        <property type="gene ID" value="Gr19_v10_g14887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14887.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16037" checksum="28AF5D5E6330EEA3" modified="2023-02-22" version="1">MFFETLKIWLNLSRLGLPSPHVGVVSERKPVHQFFSGSPTQLHNDNSYVEEPAGGFLKPDTQAMSDLVEANPCFIIRTSLGSSVQLIFGDIFKHNGSTIIGGQFFEGQQSREEKETIRLREDASYGKKRRNREERTKEFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8Z1</accession>
    <name>A0A914H8Z1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H8Z1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14901.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14901.t1"/>
        <property type="gene ID" value="Gr19_v10_g14901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000029">
        <property type="entry name" value="Kinesin-like protein KIF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="4"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="706"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="339"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14901.t1"/>
        </source>
    </evidence>
    <sequence length="774" mass="87784" checksum="9AEF30659597D70D" modified="2023-02-22" version="1">MAESVRVVVRCRPLNQREIRLDSKVCVAMDPSIGQCILHTDGAPVPKAFTFDGVYFMDATAEQIYNDIIYPLVESVIEGYNGTVFAYGQTGSGKTFSMQGDQQLAAAQRGVIPRAFEHIFESIATTEHTKFLVHVSYLEIYNEEIRDLLGDNRHKLDIKEHPEQGVYVAGLSMHVCHNVSDCDRLMTTGFNSRHVGATLMNEDSSRSHSIFTVYVEALNESGNIRMGKLNLVDLAGSERQAKTGATGERFKEATKINLSLSALGNVISALVDSKSTHIPYRDSKLTRLLQDSLGGNTKTVMVACISPSDNNFDETLSTLRYANRAKNIKNKPHINEDPKDALLREYQTEIERLKQLVQQPATNGIHPDVHHQALSEFEQEKQKLRAEFELAMQELKTSYQQEQKSKQKLQSDLAKLRAQYEKANDEIEEEAKQTEENAESAKRRIHQLQQQLVGGEQAGNEALKQKRARKIKEAEKKMKRLAEALEMYKDKEDPLLHVYTSTQEKLDALVQQYNLEKKKVQALESDMHDLSSEFELDRLDYLETIRKQDQQLKLLCQILERVQPAIHKDSNYSNIERIKRDSVWNIEAESWALPELTFRQALPTASAVSPSARIELGNGRQHQERIEVINDEPEESESRLKKRLDQSMDNDFVQRYFRPITRQNILDKYNPEKHRILAAQKIAEFTRRNQFASGVVYTDARYAAGEQQNTNHSKKSNNHHNNGTTAKAGTSGYAANKSQQSNDASGANRPISGVQRKAPARLEAIQVVRNKSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9C2</accession>
    <name>A0A914H9C2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GH18 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9C2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14465.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14465.t1"/>
        <property type="gene ID" value="Gr19_v10_g14465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073:SF4">
        <property type="entry name" value="GH18 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037410215" evidence="1">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="24"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14465.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38201" checksum="104DF59506FC308F" modified="2023-02-22" version="1">MNKFLGILFCAWIHQLAIVSVSSGRVVGYYQGNRALTSAQAKKLTHLILAFSVPDAQGNLSPLTSVQAQTLTTGKSANSALKVLIAIGGGGFNASIFTSLTSNNGTRQEFIAKIVSFLKSNGLDGANIDWQFPTVNDKANYVAFLHELNMALPSGALLSIASAASAFYLDPGFDLAGIATAVDFINVMCYNYYGGWSTESTGPNSALYQGTNADPSDSLNTNWTIVYHLTKMNDPEKLNLGVPFYGKYWNNVGAPLNGDGLWRQLGTYGTELAWRDLGNNSDLTKMSYHKTAKTPYIYDASSKIFLTFDNPQSLEDKLQYVASQKIGGTMIWAIDQDDDKLSLLMPFQNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB71</accession>
    <name>A0A914HB71_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosome maturation protein SBDS</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HB71"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15910.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15910.t1"/>
        <property type="gene ID" value="Gr19_v10_g15910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="7">
        <location>
            <begin position="94"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="8">
        <location>
            <begin position="157"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15910.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27138" checksum="B38F63E205290C0A" modified="2023-02-22" version="1">MSGQIKTPTNQKLLTNVAVVRMKKCGKRYEVACYKNKVLNWRNKMEKDIDEGQLAKRDDLQAAFGTEDQLEICKMGDLQVSDKERQVTSESSIKEVANLITNMCVNPETQRPYSLATIEKALHDAHFSLKNNRSTKQQALEMIPKLRESLKIDRAKMRIRVSVPGKNAKMLHSKLKAYFDTVEVEDWDKGDLEMVGLIEPGSYKAIVELVKGDKKEKLEQIGLELLSLKVIGENEVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBU5</accession>
    <name>A0A914HBU5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBU5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15635.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15635.t1"/>
        <property type="gene ID" value="Gr19_v10_g15635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000082">
        <property type="entry name" value="forkhead box protein B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF377">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15635.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45853" checksum="287E48DCCB36F6F7" modified="2023-02-22" version="1">MLSRRGGGGRSRIGCIRTVVANVQKRRHRRRAFTQTGDQPTNPGLVWFLTFGGRLLLHQPNKFNSNFKIFLRHKILCQKMPRPVKSSFEDQKPPFSYIWLTYMAIQSSEDKMLPLTDIYKFIMDRFPFYRQNTRRWQNSLRHNLSFNDCFIKVPRRSDKPGKGSCWAIHPKAIQMFENGSCLRRQKRFKLDPFAPGRLSKRKMAAQRTEGGKRKSINGEELASLAARRRMRTTGGSAEGLSTEMGVDLNTNDAGDGDSSGEEWRQREQQQMAATMMVLSSAHRILMLHQLGELCPPPPTTQAMLPFLLQPPPFIAPPALDNICPHHLPLFNQQQKQQQQHTFALSPVDVKHSLQQLLKLPIAFQQDQAVHPPVCPFLPLPASSSSYSSSSSSASSAFSISSLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCR3</accession>
    <name>A0A914HCR3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCR3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15912.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15912.t1"/>
        <property type="gene ID" value="Gr19_v10_g15912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15912.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9267" checksum="1BDC164362196C51" modified="2023-02-22" version="1">MRLKDSRRQQRNRRGLKGIKQGDLSKQKSADSMLCNYFCWPPAAGNDSLNRSKRPFVQFMEVELGQFGRNRFIWGPTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEI9</accession>
    <name>A0A914HEI9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEI9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16786.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16786.t1"/>
        <property type="gene ID" value="Gr19_v10_g16786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036839005" evidence="2">
        <location>
            <begin position="30"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16786.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="19923" checksum="DE0891555FE06B50" modified="2023-02-22" version="1">MCRRPLPTAAVQLLLFCFFFALLPSQSNALTCGYGQRTESKVVEESYQKKCDSTYIACRLASCSSGEKAFFAWGCSLVISEEGSNCKSLVTADVTEDYPSEHEWTCNCTFGKLGESVDMAPPDLPSTTTTTTTTTTTKRSRSTKSGGGEKSGGGRLIVKTQLVLTLQMFIGFVPAMFVGLSGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEM2</accession>
    <name>A0A914HEM2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosome maturation protein SBDS</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEM2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15910.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15910.t2"/>
        <property type="gene ID" value="Gr19_v10_g15910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="7">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="8">
        <location>
            <begin position="155"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15910.t2"/>
        </source>
    </evidence>
    <sequence length="237" mass="26953" checksum="1873DEFA0477972F" modified="2023-02-22" version="1">MSGQIKTPTNQKLLTNVAVVRMKKCGKRYEVACYKNKVLNWRNKMEKDIDELAKRDDLQAAFGTEDQLEICKMGDLQVSDKERQVTSESSIKEVANLITNMCVNPETQRPYSLATIEKALHDAHFSLKNNRSTKQQALEMIPKLRESLKIDRAKMRIRVSVPGKNAKMLHSKLKAYFDTVEVEDWDKGDLEMVGLIEPGSYKAIVELVKGDKKEKLEQIGLELLSLKVIGENEVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG60</accession>
    <name>A0A914HG60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1707.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1707.t2"/>
        <property type="gene ID" value="Gr19_v10_g1707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052664">
        <property type="entry name" value="BTB-MATH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743:SF171">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743">
        <property type="entry name" value="MEPRIN/TRAF-LIKE MATH FAMILY-C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="228"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1707.t2"/>
        </source>
    </evidence>
    <sequence length="447" mass="50705" checksum="4B5AEBB225D9E340" modified="2023-02-22" version="1">MPPVTEKGIPIESENKKANATKAKKKKLPKKLKECFECVDAGSIVLIASYLDIPPEPIAEESSKKAKKKRRAPFETPAHEFGCIQWRLSLVHQLRKDGKGGFSKHILKLALHSDHRKDIAWRAELSGTLTMKKWTDKVPEGTNPRKLNELAEHFATSFNQFSQMHSFRTEFPLPIAGNAFASADGGSCDLANVYLKNRQFKFELQFLLLDVEMGHTPLLDFQKNQSLRNAVINVGTRKFYVNKEYLSMYSPIFATMFTSEGFVEAREHQATLEGVTPLAFNECLHLLYDPLRLPEERYIDELLELARCYTIQVLTERCEKKMLFMRNDDTTVTIEKRMQRAEDYGLLWLKASLIMKNDADVLLKIERISDMTREVLERKKIATVEDEEEKKKAKEEAKKEKKMDVDGQQQNKPGSSSAAVHGRGGGGGGNRGRGGRLRRGTRGVSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGZ1</accession>
    <name>A0A914HGZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17407.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17407.t1"/>
        <property type="gene ID" value="Gr19_v10_g17407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17407.t1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45767" checksum="51CB34CFA9A1FD8A" modified="2023-02-22" version="1">MGAFLDKPKTEKTNDAGVGRDYRYVVASMQGWRIDMEDAHHVQITIGNESPFEEWSFFAVFDGHAGSKVAFHSAQNLLQTLLATTEFHEVKKELKINGPKITEKAKSLIHDGVRRGFLELDTSMELLHGSGEKERSGTTAICAILTPDYVFFANLGDSRGLLSRRSNTIFSTEDHKPYLEKERDRIVKAGGSVMIQRVNGSLAVSRALGDFEYKSVPGLCATEQLVSPEPDVYIVPRDKDDDEFLILACDGIYDVLANEELCSLIRSRLSVTEDHKGSRDNMTMIVVIFDAAPKVDAKLVELEQIWLTKIEKRVREILYESPQEVEDADTLTMMLKDEGFDENPSPSLSKRDALYSDSSKGLAPELRRKSDEKNVPVTDMETQAKEVLPNLDHKTEWIDWLFAFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH90</accession>
    <name>A0A914HH90_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH90"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1734.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1734.t1"/>
        <property type="gene ID" value="Gr19_v10_g1734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037823689" evidence="1">
        <location>
            <begin position="24"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1734.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27209" checksum="A599DF7C432C9917" modified="2023-02-22" version="1">MMGLSTKIKFCLLTELIISTIIGQHRRHVVGGTYADNGTTSTAGTPPPLAVVIDVGDLLAVNLTVCDRFGRELRRACKMRLQFWLEARKAEREGRLLPATELPPPSPGLGMPTFRKPTPAEKAAQPPPSVVSELYACFNTSCLSTYMPGFDSPRSGPCSYGRRWRRGLDGSSKTILAKCERMEYRMLSDNQRARFHAALLQLKNGFGSYEYDRISFLHSNARMMPCAHGAPTFVLWHREFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI31</accession>
    <name>A0A914HI31_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine kinase</fullName>
            <ecNumber evidence="2">2.7.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.3" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HI31"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17716.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17716.t1"/>
        <property type="gene ID" value="Gr19_v10_g17716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004054">
        <property type="term" value="F:arginine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07932">
        <property type="entry name" value="arginine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000006">
        <property type="entry name" value="Arginine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000003">
        <property type="entry name" value="Three-domain arginine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF38">
        <property type="entry name" value="ARGININE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="11">
        <location>
            <begin position="122"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="125"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="285"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="313"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17716.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40005" checksum="FD9474AA79C93B0E" modified="2023-02-22" version="1">MAVPKEVIDKIEAGYKKLQEASDCKSLLKKYLTKEVVDACKDKRTKLGATLLDVIQSGVANLDSGVGVYAPDAEAYTLFKPLFDPIINDYHGGFGPGSKQPATDLGDGKTQMLTDLDPEGKFINSTRVRCGRSLKGYPFNPCLTKENYIEMETKVKGVFEQLKGDPELGGTYYPLEGMTKEVQNQLIADHFLFKEGDRFLKEANACRYWPTGRGIFHNANKTFLVWANEEDHLRIISMQNGGNVGQVLERLIKGVKAIEAKVPFSRDDRLGWLTFCPTNLGTTVRASVHIRLPKISAKPDFKTICDGLKLQIRGIHGEHSESAGGVYDISNKARLGLTEFEAVKQMYDGVKHLIDLEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI39</accession>
    <name>A0A914HI39_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g17571.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17571.t1"/>
        <property type="gene ID" value="Gr19_v10_g17571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000088">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF121">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1018"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1117"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1153"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1178"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1231"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1419"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1509"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1544"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1616"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1649"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1677"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="17">
        <location>
            <begin position="827"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="1079"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="17">
        <location>
            <begin position="1276"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="1422"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17571.t1"/>
        </source>
    </evidence>
    <sequence length="1762" mass="198598" checksum="7C252D8EB96A9C64" modified="2023-02-22" version="1">MGKEGFKNYSSALQNGNVNSTKKFRTMTFDPIALRYIGKNVDRMEQCKYTSLGETFNMCFKLIKSESRLVKSILFSYGFLQCSSKNQKCNLMWTNTHLSTLSMRQLHPWQRVNHFPRSWMLTRKDQLYESIERASILYDSEWFNFIPDFFCTPMSDTARLSLRHKLDESQFGLEAKFIVKPADGSLGRGIYFLNTANLEETFASAKKMLVSRYIDPPYLVNGLKWDLRVYVLVTSFYPLIVYVYSDGLARFAVHKYDHADDIASEDYADLNKHLTNYSLNKASTEFVRNTDCTLENMGHKWTLSALLRELEKRGEDVGLLMIRIEDIVIKSLLSVQSSVAAMCRKLNVHPKCCFELFGFDIMVDEHMKPWLLEINLSPSLTCDSPLDSLLKTHLFCNSLNIAQVPLVSESNMLNGCFASDSELDENGCTVKGDTDKVTKTGSQDSDQSSTASTAASSVASMTFSSNPASTSSASTSSAHQSNGVKRKGYGATQFVGKMRKLEQMRKICYSAERVTPQYLERLKCYFDKLKSEEKHLGHFNRIFPRRWTWPLYRTILEDCGQEKWDEALHDRMVGEYPPGDACDIELTLTDVRLAHEQLMDAKSFKRREQLNPMVRDVLLAEAFAGTDCYKRRRYSGDIIPFPSALPRIRQGARRRTKSQVVAEEAKRVRTEQQRKAAAEEMRQCDDDNGTLAVGVQETTADGGQWATKPLGEVNLNVGQQGRTPKMDNEESNVSQSKFICWLWRSSARSSSSHFPQKVSRHSHAQAQAFASAAGQREQNGHQNQPEMCSVAFPDDVPNGDLCGGGSPLSSTADNQRAFDRALPAAQLRVNVGGRSAQLALDKISQRADRSRLAQFAEKDHAQRLLECDAFLNDEYYFERSSTVFENIVDYYVTGKLHRPMEICPIRWREELEFWHIPLSTLSECCRADIFVPKRSLASPALLSTDNVYVESSCPPAEFEGVPLSRARLVLWTFLENPRSSAAAKVLSVVSASFVLLSLGGLILSSMKEFQVDDGLMTPIWPLQLSEICGMLFFSLEYIARFRRRPPQMDVRQTAPEHHRPAHHRPVPSRGLPAPSRGALIVIRVLRLARVARIFKLARYSIGLRAFGETMRKSAAELSMLGMFLLTGIMLFSTAIYFFERDEPNSKFYSIPSAWWWCVATMTTVGYGDLVPVTTGGKVVAAIASVCGIIVLAFPISMIIDKFAESTGHGARVFDESAATAPGGALPTTREFVALIPAHSSSPLIVPFSAALLQLSRHKMCWDHRPTSPAAREELFRLNIGGRSFCFRRDTVLEGREPNSFLARLVRLDHSKRLLLTDGFMTKTGEYYLERNVRVAEHVVDYFLTGKLHKPVDVCPQRFSEELIFWRLTRVELAPCCSVLADSSRLKKGLEAERQLEQMNCCRELRKVVWHMMEAPSSSIVSKLFTLISVLFILASVVGLVLGSMPEFQADNRFSEHYHALLSARKGFGQSQHQLEMDNAIELLAAKASVNNASGGNNHSLACTKDNPQAWLVLLEYCCIVWFTLEFLIRFVVAPRRLNFIRQPMNLIDLFTVLPVFCEAALSALGVNAERLKDLAGAMLVIRVLRVLRIARVFKLARYSTGLQVFGMTLRNSLRELCMLSMFLLCGTVFFSTLMYYAEKDEPGSDFRSIPAACWWCIITVTTVGYGDSLILSWVGKLVAALSSIFGIIILAFPISMVVENFAVAQQKSKLENQLREVQMASVANDYLMRRYPSRRKACRDPLELPCGGSPYSALNELNFDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HID7</accession>
    <name>A0A914HID7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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    <sequence length="207" mass="23158" checksum="07A34E98298F328D" modified="2023-02-22" version="1">MVRPKRQLAPEKKAEVEKLLLETKGKFKMDLRELELAKRQFSTAFVGAMATELPKIFPEEVLDMRLNDFIKQLGDQAYDFNDEPDQEGTSKGATAATPAFPRRPLTYKTMRTPAGLSIKVPSCITPKVEGSMARTGKRGEVLFSVHGTPVMNTMGPDKTDAVVQDWLQQEEERLTPQTREIIVKLKELVHMRGKGNDESGGEESDGH</sequence>
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<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A914HIS9_GLORO</name>
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            <fullName evidence="7">Diacylglycerol kinase</fullName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
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        <scope>IDENTIFICATION</scope>
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            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
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    </dbReference>
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        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g184.t2"/>
        </source>
    </evidence>
    <sequence length="2378" mass="257869" checksum="6DF7218D46770059" modified="2023-02-22" version="1">MNDAQSSNAKRRPALVATAPIAWRSHSAPPRKKWYRRGPQLLNRQRSTTQQSGSMLYDQMVARRLVGAIAAWHDLHASLLQLSLRATDDDVGVEMRRRAKRGGSRVSSRASSICSSVAGHGRKKASVRRVTSRTASGRRQCQRQISARRSGRNRLRVSNSRGPSPRSSFSAGSARSSSIADGGVGCGAASGSPRRCSPRSPSRSSSGASGGSSSGAENHRGALTVTGGGPSTSSSQLLPCWRHRHDLSPHDFGFSNSSPSSSLAVAAAEPRPTAATWSATFAQSLQIRRPPAAAVAGGSRKTARSSSNCDGEQIVLKHHVKLLDPVVSYPPVQHQCARCCLLPPSPQPMLLSPPSTISHHYCQRRCFSVSKVDLDVPTSSSSMLGDELRGVHQRRRHHRHRCSCGEEEGDETADDEHDDDGGEEAAEDGEDELEDSASSDGAVSDTELDALVADEKHRPKLSLAEEPELSPEQLRQLFPELSEHWRSNGRRDELLSFVGRRLKLSTVCASVMLQSLARFKKSSTDNDRKDTQKQPMDLSSSTKPADSPPSLTSSTTIGLIGAEQSEAYDTIPNCSTTIAKATNGVVVNKKRLKLNCGSTKLKQSWECQERQSPIIEDSVMDAFVEQQLPSTSCSIHSRTTPPNFSFEPDVFRQTVALCSSPHSSATSPGGSSSTLSHRSFHVRLPDAVANLRKSGVHLVRNFRRSSLAAMMRAMTISSAGHDQNASSAGSKVNGGMVEDRPPLYGGIKCPRHANDGTGAAGPFRCRTTTGISTHHWTATTAAVVESVPASTDESSRHSTMTCGGTQRRKRSGGPGSGARRAMRKRISAARLALRKISRISTQSGSTIATVASSSSTHSSPKTPVSVHGYCGGNSPVWQSLNSNSTEHPLKKCLSRQLLEADEQNNNNTNNKAVNDNDETEQQQQLVPMNGTGRNGVGAISWNGDEHHHQRQRHGDNDDEVENNRSKKLRKRSRTLAVAKELLFVKSDKKPLGPSLSWDPQQRQQHQKPSRSRTPLSALDGTNPRDRIHSDGSAEQLVHMRNSKSAILLAGKNVPSTKGRGGGHFEKKSKGKRRKKSGTLLSGAERVEKVGLDLNCLHCALQAEHCASTLRSEIECAVKRLAIRLNSGGGDDGAAGCRALSPTATCRKRAATTTVVRVEVETERQQLVQQQQQLRRTIGTPDIVISSYNSEDTPAESADEGFWTTSSATVKGVKQQQQHQNQQKDNKLGSHSSSNEMDKGHSTESQLANAETNDQQLPYGVWSPMDTLKPPGGAPFGGSNTLYSSGSSASGSVAFIPSGHSLPGGMPSLDAVVGDHLNTPPRSNSVDLSLLRRDIERWSVSNLSIAGSTTDLEMVELKNNRGTGVSTPGGDSMRTVRSRSYDPTSSPDFILRRPSRIEHLSEIFRRALAKSPVVKRAAVMQEQELKRVSKHRTSRYWLEDQLGPSEHIWLTSSASASSTVDTECYLGEKDCQKMGEKRRCSGCHIVAHTACFPLLAKMNLSCKTTFRDCAVVNAPGAKSPSPAGTKRQRQSNKGELCSSSNNNELNNNNNNNNYKHHWVHRWRLEGRCSHCGKSFQQKMFREKEVIAITCSWCKRSYHNKRHCFSLARFDDHCDRGVLRELILPPGWLLRLPVARKRSANASGVTRALSVLDSVQQKRSKRCKYRTFVVKPPPASAATSPQAQNMANTYSRWSTAAQQLPLPIQPLLVFVNPKSGGNKGAKALNMLCWLLNPRQVFDINVMRGPKYGLDMFRKVHSSMRILVCGGDGTVGWVLSTLDLLGWPAYPPIALLPLGTGNDLSRAMGWGGTFSSDEPLAEVLAAVQTETSVTHLDRWRIDVCPLATTTTTTIAGGAVCNGTETENNAGGLNNNQNDNNNNNNNDFKMDQQQQQATETSAAGPATSTSSSDGAQAVPGPAEEAAVQSQLPLSVMNNYFSIGADAHVALQFHQSRSANPQMLNSRLKNRIAYGGLGTIDLFKRTWKDLSEYISVECDGVDISAKIREFKFHCVLFHNIAFYAGGTVPWGAGDGVHESCGEVFSRPSPCDGKIEVLGFTTATLAALQMGGKGERIAQCSKVRIETSKPIPMQVDGEPCLLGPSLIHLTFHNKVSMLRREKFARPPGTAPCNNIVSMGQNRRKSSQNSSANSSIAGGAGGGAVQASTTMMTTAGANGNGTVQSGGHKNSRANASPEGPSSASPLTVTAASPPTTMLLDVPVIVVGRHDYDTYRDSVERLKDTGFELGILNVEAETELAQLRQHIQQMMCEHQILPYDPGPEWRFLDYVSSAEEGTFRVSRHQEQCRTVADVCSLEQVECRPGILILDDAFPSMNARAAAIGHELVFTLARKAAAPTTTSDRRNTMIRRRISETLRIVLANDAPETHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ16</accession>
    <name>A0A914HJ16_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1911.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1911.t1"/>
        <property type="gene ID" value="Gr19_v10_g1911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1911.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16051" checksum="0B13D7B3082FE48F" modified="2023-02-22" version="1">MLQRRRRKRMNSLNIESGEGGGRTNDRNLGLFCSKIAEQHRNKNRFKILGTGTEQAKLEQGYYSVLAKQPIPTGNVGIFYFEVKVISKKGFIFIGLGTKSMPLNGWPGHYKGTYAYGDGEFWGHDVAGCFYYGTSRLPYIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJP8</accession>
    <name>A0A914HJP8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1942.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1942.t1"/>
        <property type="gene ID" value="Gr19_v10_g1942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037401292" evidence="2">
        <location>
            <begin position="24"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1942.t1"/>
        </source>
    </evidence>
    <sequence length="682" mass="76983" checksum="3D4010E87E6F0503" modified="2023-02-22" version="1">MKLFVLSILPFFLFIIGTIFCQAKEDNCEDGADKIYECTDRSADCIAIETLCDNFFFRQCARSACPKTCKVCHDSEEHREFVITSSPAPSASTTNSISSSNPTTTMATMFSSSSSSSSNTTTSMATLFSSGASSSSSSSTSSTPPLNEFSMDDMVVEDGGRVEHLAYSPPNLYIDKNVVEEDRIVVNVMNGSEFGKMNSTGPVVVSDYYGADRFRKDQSDENESPGRWSRNNSWRTTNNNVQKNSVDWNSSRNRSSRGSKWADFEKDKADDDGMVDEKAGKSAGWKKTWTTSWSWNGQKGGDNEEKEEKEAGKEDAKDNEEDEIEGEQQAVQAGEVSAYDKRRNWNKRWEEDEEEQGAVEDEAETENDGEAVEEEKEEAMEEGESGGGANWKMSWTTSWEEKEGDEDDDKEKEEEKEEEEDESAQEGDEGEWKMSWTTSWEEKEEEQHGDDDVEEGHEEEEEEGYKEEEEEEEVDEEEEEAMEGRNTLFKSGGGRKWQKLWTTTSWEEDENEGGVEDGGEEEEENEQSESESGRRSWDKMALGSWSGNWKKSGEILDGDQTTGWKKAWRKEWKNSDEDGETEWQRPEEWVGGGHGKTSQHSEREEDGGGASLTTNEKLHGTAEMNERQNEDNAGADEQLAKEAECKQMCAKRKVDSANSAQKRNEFREFVDQAAQMGCQCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK36</accession>
    <name>A0A914HK36_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 130</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HK36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2047.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2047.t1"/>
        <property type="gene ID" value="Gr19_v10_g2047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2047.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33723" checksum="4E802192CB99D489" modified="2023-02-22" version="1">MGERKGQNHYYPPDFNWKTHKTLNSYHGVHALRERGKRANEGILTIRFEMPFNVWCLGCNNHVGMSVRYNAEKRKVGMYYTTPIYEFRMKCHLCDNYFTIRTDPKNFDYEMVEGLRRQEIRFDPSTIDNFAPVDRTMSLKLGADAMFKAEHTVEDKQKLAGVDEQIQRLETIQTRLYDDYAANSVLRGAFRREKKYLNERRARDQAMKARLSTELTLLPENEEDRLSAQRLAMSKQFIVNKSGDEKLTKQKLLGNSPLLHQSNGTKHDQQVKRCSLGICLTKKASENGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKN4</accession>
    <name>A0A914HKN4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HKN4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2204.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2204.t1"/>
        <property type="gene ID" value="Gr19_v10_g2204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12384">
        <property type="entry name" value="RRM_RBM24_RBM38_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000077">
        <property type="entry name" value="RNA-binding motif protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="187"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2204.t1"/>
        </source>
    </evidence>
    <sequence length="503" mass="54317" checksum="FAEFEE28E683F25B" modified="2023-02-22" version="1">MSTLAHPAAHRHLMPHYYFPSRDRPPPLQQKPFSLVAGWLIGWQQLISRVGTSRADLTQKYNRFSARLTHSPHQLNNYYHGCSFSSQFIPIFTVPGAEIFQAVFHSCAVNFFLWTCDVFFAVFSSYLFLAYCSVCWEFSISCFEFWSHFYTSIGRRLNITFGDVTRRSAISTGTETAATGSRDTTHTKIFVGGLPYHTTDQTLHDYFQQFGDIEEAVVITDRQTQKSRGYGFVTMKERIDAEKACRDPNPIIDGRKANVNLAYLGAKPRNNSHLAALSSTLNQFPQLQAAQLQAVIQLQQQQQQQQQQQQLGGRIGLNHQLYLQGNTIGQQLAAAATVNPLAAVQFAAVASQAQPNTLAAVAAQQAAIAAANPAAAAALFQQHHHQQQPNAAAAAAAVSAATGGGANPYLDYHQLLLAAAAANNPQSVAASLAAGYGMPGIYSVLQQQCSSSVAPTTVTSAQNYAAQLAAQAQLVAAQAAAAGANGITTNSASGHSRLDTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKN8</accession>
    <name>A0A914HKN8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKN8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17757.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17757.t1"/>
        <property type="gene ID" value="Gr19_v10_g17757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17757.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40455" checksum="1DE37BBF4BC8F059" modified="2023-02-22" version="1">MSDHPREAQRRLSKIFVCDDIWLSTFPSLGPAVLGLKLALLSDRFDTLVDLHFKKRKWTLGELKIQRFPEGNGAAQIAVMRRKVIKQLLPIPQQPLPDNIIGFKHIWICTIDHTAIAFLHLIRRLFSADTMLRVCTNRANNNDVWGEITRNIWPLMVNSVGKLKFKSRNRLNTLRIRIAPNVLRNLANLRTIVFDSFYFYRFNPLWPDDRAEAPADRALSKWLHTPREDGRPKVLKFNDHSETYFPNAAINHLKEEFRNASTSASYIVVLCCVCAEFDEFEPFELINRQTRERFALELAQHDMLLLRRSPIERDEAKWAEGESEATKKPLPHHDPLPNSVTVDVQSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL50</accession>
    <name>A0A914HL50_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL50"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1801.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1801.t1"/>
        <property type="gene ID" value="Gr19_v10_g1801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1801.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14842" checksum="D7316B1BA91051BA" modified="2023-02-22" version="1">MSVWEIQEACRIVCRSPNICWEPTSYTDPQICLPPGTNPNNFKNFVSLTDYSFMFVLLMVFVGGLAIGVIISALFLVVKKNCNCYFRHNSRCQRKNNRSTNSQTLAHLAGRSRQPPPVHTPLIVRLPQDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL62</accession>
    <name>A0A914HL62_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HL62"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17639.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17639.t1"/>
        <property type="gene ID" value="Gr19_v10_g17639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17639.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25502" checksum="67D23A77B31B9098" modified="2023-02-22" version="1">MTDHQQDTNKRRTRRSLFGSGRPNDTDEWLRNLENNAMEEKVRQWNFDFRRGRPLKKAGVDSPSSSHVYEAVDEREVPEFYRPDVAPEAASEAVRIPEDRADFLGKGRVCGVVQSAQEQTVAEGEFDGEHAAEEKEEILLPLSASTKFDAYDKQLKAFVHPPLNIQSGWCEERGTGAENNSIVVKIRNQNKTLHAFLPSGKRAVIAKRLNSKSLPSACFPPTTNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLU6</accession>
    <name>A0A914HLU6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLU6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2682.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2682.t1"/>
        <property type="gene ID" value="Gr19_v10_g2682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF5">
        <property type="entry name" value="CATION-TRANSPORTING P-TYPE ATPASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1067"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1102"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="9">
        <location>
            <begin position="103"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2682.t1"/>
        </source>
    </evidence>
    <sequence length="1137" mass="126704" checksum="097152CEC1231F4B" modified="2023-02-22" version="1">MSTNKVGLPTAFETKKISSVNYAVESDKAKTAGTALKKAAPKRGFLSSWLMCCLGERAMPRHNRMSSQTGSMRSRSWSMRQKGLSGAFCEHTWDIVQLQDNFPESSIDTADVRRSRGLATDRALLFLQRNGPNVLPAPKEMSSVELLIRQFWNLLWALLIGAATLSLLQFFLDTSEMINLYITLILYGMITVMCVVSWLEELRARKVVRGFQKLLPSSCIVIRDGMERSIEAQQLVVGDIIRIRAGNRVPADCRVLHCSELKLESSSITGEAEPIEYQAEEVAELVSVFEARNVAFNGSLCVEGDAIAIVIRVAVQTVIGQIAHLTTGQQSNESRLEMQIRKYVKFLIVLACSTALLLSNGFLVCAIGMVPCGLPATVTSILTVIARRLASRNVYVKRLDICEALGQVAIIASDKTGTLTKNEMHVTSLWHCNKFIAGMPKKIDENLLKKMLSNYCSPLCDIFECMTVCNSASLNEINTKKSGTIASDADRPDEDDVELGAEPVVNKFSVAQKFSRSISMIGGTIHRQDTTTGRGKKKVMGSPSEVAMLNYVNALIDVEETRGRHNITFEVPFNSKRKWHLMISELSNNKKNGLKQYKLLMKGASEILSHMCSTYVDEHGHQQKLGNMELKQFEDAYTHFAERGHRVIGFATKTFSAPWDTIFDLDEGNVPLEDLTFLGMCSIMDPPREDTSEAIKQCKHSGIKVFMVTGDHHLTATAIARQIGLIEDTQKTATIQSNGIKTPPKELKKSQSFTSHQQLALCVPKLMMKTLSTELPLSEAEKDYEIVHGERISRLSPLEWDTLLKKDSVVFARTTPEQKLMIVEQCQRRGKLIAMTGDGVNDAPALKRADIGISMGSGSEVAKQAADIVLVDDNFSSIVRAVEEGRVMYENIKKLLAYTMPHSFPEVWPVIINFCFGFPAGITALQILSIDLCTEILPGVSLSRELAEGDVMARPPRAMNKVLISNTLLAYSYAYTGQIQSLGCFLAYCWVFWSHGISISDLWMSALNSWKPDGETFFSNGKVFTVEQQLYIGRQACSAWQMGIVFGQFFNIWSARTRRVSLFRHGFFSNKALILALLVELALIICFVYMPGLNHFLGGAPIPWQCWAVVAAVGMFINVYNEIRKYFVRHYPQNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM05</accession>
    <name>A0A914HM05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g2730.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2730.t1"/>
        <property type="gene ID" value="Gr19_v10_g2730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041793">
        <property type="entry name" value="MyoVII_FERM_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21998">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="79"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="12">
        <location>
            <begin position="987"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="12">
        <location>
            <begin position="1650"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="1815"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2730.t1"/>
        </source>
    </evidence>
    <sequence length="2035" mass="232015" checksum="68001815F21ED3C9" modified="2023-02-22" version="1">MEEVLHISKGDFLWLDTANHGGNGVAIGARVLSVFCDNRSPVGERRILLMDDDGKKIEVNSADLYRNFNARSMHPTSIQVVEDLLHLREPHEAAIMRNLQIRHREGINYTFIGQRILLALRPIDNKMTNSFKQFNALYSSHSPLELPPHIFSIGADLLQKMGKNYWTDEDESTHSLPNNCCVVFSGECGSGKSANTRHLLNFMAENAAGPMMDEKLKAIHLLLDAFGNAKTASNLNGTRTGKCWELHFSDQNGKAKLNSANIEHFFLEKGRIVDASIWPENQSNFHIFYSLMAGLSQKQKLDFGHSAADQAKNYHFLDRNKNVNISDPPTDLSEICSALRTLLFKETEIDSILRILSAILHLGNLRFDVISTGDGIERVEVNDRKNIGRICTILKLDESNLLCALTTKRTLLKNGESFAAAASLDVRGALDARDCIVRECYSKLVGQIVTKANGTLGGRRKEPNPSGIICLVDFPGIETNFEVENNFEQLCINYTSECLQQFFIRRIFKFEQSEYEAQGLPGWAFGSIGFSDNWPILDMLAVNSLSLMAVIDDASCAPNATDDEALERLHNAQQRNGQHFFLSPKSRLCAQFVVCHYTGQVAYRVKGMLAKNRNQFAHQLRLLFLGSQLKFVQRLFELPAQNGGNEWITENEGTFAQLRQQTLANCCRLKMDALMGRLEHCAEAYFVRCIRPNDSAGGEKHFDRPAVLRQMRQLDLLAVVEQCLAGFSAKFEFANFVSRYRILVQNFSALRKCHCVQETRAICQQIFEANGFNGPPVAFGKTKIFLKAEGHLMLEQLRKERLQRCAVLVQKYLRGWAQFRQFERLRWAAIVFQKNWRTFAQQRNYQKLINGFTRLQSLVRAHHSVLRFRQLHANIVQLQAHCRAVLLRHQLYSERTREDRRRAMNLRLEEGQKVAAEPPALFLHAVEFEAGRDCVKNLCGGICVRFDGPMLAQLEGKSWSIDVELANFKWEKFMLAYFQNFSMFHNNCRRPIHRALLAQKYEMDEICATAIWCRVQELMGNAFGQKKIKLKSKDKVPIMLRLSAMFGKNYNSAALKQLKYAVLKYSNSIMEDGTPSLLDNILICCGEESALDKIQLIVGIGILRAKLRDEIFCQICTQIGQNPSERSKARGWTLLTLCAACFSPSAQLWPYLLNFVLRFAPTRHIFCRIERSLTRIRRFGARKEPPIEAELFSSIFGDSQMFVPIQLADGRVIPLQIIDAIASLEAKSERNWRILFRKELFRAYESDCADAVAIDLAYRQIVHGIHSMEYPCKKEEDLFTLTAQQHFIDIHGNCEVDVKFLEEQLEEMLPIETLNKKENDEENIEIERQRWVQLIMHTFRKKVVKDGIAPSVEFVKCQVIEFARIHWPIIFSRFFHLNKFSGPHLPCNQISLAVNSDGLILFDPPRQNQFAEFAFAQISAVSHSHSKRAGAQSISVQLLNGDRFTFQSPRSPELALLINQILHQLRLKSLYAVALQNSSAGNAFEYARGDLLILNVPFGEQTPNDWITYLFIFLVENAHIGMHGKIALNAVHILTTAVMPTAEELGSLLTPSSHEVEEAFLSTEPTENGIVPFHSAITRLYDEYSSAAFWTFHFDFGQRMRHPPPHNLEKFAADNFRKAELFKAFAGRSEDSSIYSFSGSVEGHSDLWRHSPKPLKAPLLKRLNAGGRDEIVQQSICSYSHILMYMFDQQPMLAPAPPQHSPLEHTDAIFEAPLKHEILRDETYCQLMKQLTLNPNAISEERGWELMWLCLGLFSPSAGLLSELSLFLRSRPYPMAVDCAGRLEKTIGNVRPFSFRQCPPHQVEVEAIQHRHTQIFHKIHLPNGSHANVEVESWSVAKEICERIASTIGLYSAFGLFLFVKVGEKVVCIPPEEHFFDFIHQLQKWARKTFLRQNGDAQQNEQFAYKVHFMRKVWLDVVPGQDLRQDLIFHYYQELPKYLRGYHAIGKKDAAQIGALILRAQTKDGKQPPLTHIQHILHQLIPKDFLKAHSLAEWKRQISAEFADPEMPKSPADAKMAFLRRISLEPTFGSAFFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM60</accession>
    <name>A0A914HM60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat and FYVE domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g2770.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2770.t1"/>
        <property type="gene ID" value="Gr19_v10_g2770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="2557"/>
            <end position="2687"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2717"/>
            <end position="3009"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3170"/>
            <end position="3203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2397"/>
            <end position="2425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2444"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2527"/>
            <end position="2549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3338"/>
            <end position="3412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2444"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2468"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="3338"/>
            <end position="3351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3362"/>
            <end position="3379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3380"/>
            <end position="3399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2770.t1"/>
        </source>
    </evidence>
    <sequence length="3487" mass="389996" checksum="E9C13D1EDFDB792E" modified="2023-02-22" version="1">MNNNAGGVSSPTDRTAMLATFRKNFAAFLKTKFNKNVALPSQAESDTKYLLVQFYKIMSHFTPDELCAQFKECLSFTTHIAEELVHEIRRRASSENTREAALAVYEFVRAEPIDARGWMLLKTVIFISNSGSPKVFECFCKTLLPNTLIKVAYLFMDLPDADSDDEAAVRRRLYDSLIMLIMNLCSQPVVAEELLHKDDLMLLFIGASSHSASPSNIWRSANFTFLCSVVAKALTAPVLKYINSRKCIAQYLTNIDRSEEEDERAVLLCNLLDLLRSSADSTPRLVDDFGSAGGFQYTVQFCLRGSAKNADQVLSALAGLITAGDQTIQFSIPQQSASSHFHAQKMVPTIARSTGTIRCMLAYKVLEQCFTEGEDGLCLLALEKVLHLLRAERMNYFVVDEMSSLFVLCEQMMAKGVIVQDKMLELVELCSRLLNYVPYKELSSLNSHLKSAVVTAHNFEAAERLLHFFLKIISVNSAMRDAFRELLILETFLHILQQHSSEGTAQTQVRRVLQLAMDLLISATKGNVLNAQFITENIDIKIAKTLLLAHQTDNEELKASIAILIKQLLYLAKNEQLFSSLLQLLFSEPEHIELCTVILKLFSNVLLESHKVRVMFRRSGGFILPPPSDAQQMPSLSLEFVAQRDATLQYVALIFHVLTVSMRYEPSNSKYFLNEVRPSIINSILLNLGCFGKCAKVDTDDPIWETITLANCGAKLAAIHQCFGMGTDLYRPEKRGNGRRNGALADLPHGTFNALIVMRLLLDLAFDNFEKSSNEFCWASANEWLQNVENLETVPVLAWSNSAVLAHPSAILSIVDLLPALCHPSNLSSGDCHNQNDAANTVVERPEADHTVAQLDEWSALAQLYIALTLKAILRSERNQQTMCQFDLPAKLLAVGEKLFKTDQHPLLSSFHYLFERLAYQSLRSSELRHFLRLDKPLCCTNLDDDDDEENKGSIVKAGGPIPIHRIKAFVSMLTPRNHSLLLSPAFVEFDLAIEGFAALVVPSLVRGGGKTNGGGGQHSQQQQQQSLGNAGGSSTPPATAADAEGAGGVTFPSSAGFTLAMWVNIVDFVGKKEPSSTTPIITSSPSPESASASSTICLFSIVRNCLQVLLQRVDYCWTLVVSGAEHSVADELRKDFSRGAEQCLQVPLSEQYFPPKQWAHLAVVVSKHSLLLKSSNMYNCEVFINGHSLATQKLQLCWHSADSNGQQPGLNAYIGTLPFFRRGSIQLRWRMASLCLVEEALGADVLRKMTALGVAYTGNYQTDVSSSSTSASSHSALIPEEKVLLSLNASASAETNVLSLRSMMPCRTEAELVAALVGISPNDQSTPLRLLWNITSCPVPCRPVPLGAVLIGYLGIRTFGPCPVSALLDSVGGMAPLLGTVVMSSDFSGLYASLKVLVCAVQTNRSVFVEMQRTRGFQTLAILLEDKASLMNSHILHLIFTLAGTVDDGSKEQVVIPNLQIFEDLLCDLDVWREAPREVWKLLLEHFFELLIETSASENLGLIRRSPLLGRLLVHLIENCSLFPVQNDISFRLIGAIVQPPCDGNSLLRLGQAIAATIAFDVDETAYPFSTAQLEQRLTAETASEERRDEIRDLHLYAVYARNRLLNILCTMLHHSNSQMNKELSTLIVDTLGFGWILAFCGPRVHHGTLFLAMRILANLLRYPSLVNKFRDGSANGGWLSDADSVIRNRAAVLLGFSVANQVGAVGAHVDINPELDKCSGFASLEHVAYSHANKPFVYLALLSVLFQQHSPNIQPLGNFTIEIVWSNVFGLDEQGSVADAIERAQFCPEIIVSLLATIRAAIHRQFEMEESNEQNANDWSINYPLRLLQFFNFLYQNSSQFFAICHTESFVVVLFSSLLPMQNAPQTPNSARTSAEECTATIAEECGGNRCVKQSLELLTNILLNDLCLANEARTEPLFDALIEYMDCNGPTHNRQNQLFTELVNGCLDHFMSSKMFFLNSASVPLVVPPSAKTQLNQSSEYTSANVVRFLSRVIDTVWNGLYKGNPIRILKCFLKLLAEAHASNKAAAQLQCTDAHISSLFRLILYLLSRPIDNVDTQMCVLDTLAEIVRNQQLFLTPKSNVDPLFYAALVHLVFMLSDRPQFDLQDRRNRELERGTAQVSICAQSVWGILWQHKKAVLEEWLKKGDLDLDLFTSRAKCGEAANRAWLQFVDSQTVGNNAQSQQQQDSYASARLLNAQKMLPTQLQTKLSRVARNGLRKLRNSTAAGIAMGDSSESKQWLNALARFDDERLRVEPETFYMWIRVHISLVRELIRNQCQRYHEWHAHVQKWCVQEWHYAEAELIRERGLWGPNCGSALNKFQLDITEGPCRIRRKLVPNPDFYRHYPYRPNLEGPKAKPMRAKVAISRDSKPYWERMSKKRAETMDERIVDFQAGLMPSPGGTVADQSPGVGIEQESDQPANDSVAELNISMIKRMVEKNLEHTEKTESIGEDVKRKRESEQNVVFDDDEVEEEEMDEEDEGVRDKSPKLAKQAEGTETAELELVEKTSVDGRKDICETEQKPLEMKKHHRRRDQSLGEPISQGPDNQTLLRLLEQGEKLHSMFRCARVQGLDIMEGLLLFGKDHFYVVDGFTLLKTREIRDLDFLPEQFHDPIIPYIAMGYRSRPLSTKVNRQCNKFAYDDIKEVHKRRYLLQQIALEVFSTDGRNFLLAFPRKVRDHVFQKLVSMAKNASSDVTQFMNEQKKLRPTETSSSLIAQLLTGQQQSITHKWLRGEISNFHYLMYLNTLAGRSYNDLSQYPVFPWVLADYDSDRLDLTNPASFRDFSMPMGAQNCDRLAQFLKRFREWDDPGGTPPYMYGTHYSSAMIVLSYLVRLEPFTQQFLKLQGGHFDLADRMFHSVRDAFWSAARNNMADVKELIPEFFFLPEMFLNENAFDLGVKQNGTQLDDVLLPPWANGDPHEFVRLHRQALECDFVSEHLHEWIDLIFGYKQTGDAAREANNVFHHLFYETSIDIETIEDPLTRNATLGFINNFGQIPAQLFKKQHPQRKIQGGHPPNALPLVSPVPGLNVPRLFYHCPEALRVSARPVKELRTAVGEIIVGERGNQAVVLEQNKVLVPPNSFLAWGFYDRSVRFGAVGNEKSSCILETNDVYEITCMATTDGRQVFAGLSTGTVFVWSFCLPAPSSSVSASLSVSKSVPNARLTPKRALSAHSDVVTALAANAAHNVLVSGSRDRTVIVWHLTRLGFIRQLAIHPGPVSAVAINEAKGDIATASGAWLFLWTINGTPLASVNTADSGGLFSNASSLVLCITFSMTNDWDENNVVLCGTSDGLVKMYSLERMSKSLNVVDEDRHSSKLADPNLELYQQQQSVREHLFRRQQRIQQHHHSFRMAKSPVKTAASLESSPSTSTVNSATFSRQTSQQPTTPTQKLNNNSSNNQHEQQQRDVQCPPIGMEAVQWRRTFRLRRILSEHTAFTAGNSQPAPITAIRATKDHRSLLIGDGIGRIWMWSIVGRSDSDGQPQQQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN97</accession>
    <name>A0A914HN97_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HN97"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2343.t3">
        <property type="protein sequence ID" value="Gr19_v10_g2343.t3"/>
        <property type="gene ID" value="Gr19_v10_g2343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="282"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2343.t3"/>
        </source>
    </evidence>
    <sequence length="477" mass="55277" checksum="319AFE957547D901" modified="2023-02-22" version="1">MKKELKDMKQLEEELKDMKKELKDMKELEGELEEVKEELKDIKQLEGKLEEVNEELKDIKQLEGKLEEFKEELKDMKELEGKFEEVKEELKGMKELEAELKDMKELKDMKQLEEELKDMKKELKDMKELERELEEVKEELKDIKQLEGKLEEVKEELKDIKQYKEEMKKTNELLSTKLEQMEEWKKIAKLELENKELRAELAHQKQLNACKCMTVGEMIDMHKLKQQQNQTKEKIGNIPDFVWGCRAKSAELERKQKADQEGHRAKIDEKTVEAKAGAELEHQKLVEYGSGLASLDFGLTPQNRWDSAACHDKLAIIEPDRLIVEITGKNSIDFYFSYRSMLAERQIPKGNCGIFYYEVKILGKENAISIGLATKQMPLDDHVGHYKGTYAYVNYGRLLGHTVKPYVGGFADGDVVGCGVNLATRQIIYTKNGQRLDTANLFVDSFDLFPCVTLFFPGAKIEANFGPNFKFNVVLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP80</accession>
    <name>A0A914HP80_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP80"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3133.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3133.t1"/>
        <property type="gene ID" value="Gr19_v10_g3133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037356434" evidence="1">
        <location>
            <begin position="24"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3133.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26253" checksum="D62DC64097BD3C07" modified="2023-02-22" version="1">METFWALILVSFFATNSLDKAESVQLEELEELPLQTFNELFVDECLDKLNPIQLISSDKLNPIQLISLDKLNPIQLISLDKLNPIQLIIIFLLSQSLITLITPRQSEILLKMSKNNKYSDSEQKELMKSYYEIKGQNPKTSDEKITKRLNINRATLVCVGAEHQGSTFHCHQVPEQSAARLQSLHAQLTTLRDTSNGNRAEEEAVTATAADANARPNVYVLLFHRTVYVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPQ1</accession>
    <name>A0A914HPQ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPQ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2750.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2750.t1"/>
        <property type="gene ID" value="Gr19_v10_g2750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2750.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14502" checksum="F5E9328F5949C7D3" modified="2023-02-22" version="1">MNQKGRALRIIAVTSPSYSAWILHISSIAINTTILELFISKSFFQMSSTPPAPLKPTDEAFLNYWLYNSYSPMYASPRDMAFNRNGSVYSWLLRKSYHSNRPGTYFYRPKINVHPNERSKTKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR09</accession>
    <name>A0A914HR09_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3449.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3449.t1"/>
        <property type="gene ID" value="Gr19_v10_g3449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3449.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12654" checksum="C71606ED941A5300" modified="2023-02-22" version="1">MARPAIWLLIPAFLEKKPEKNFEKEPPDLAILECKSLGHFITTIHPTTAQCGHDDCFVIVLIVNALCTIGTSQYSPFTEMYLPVCRRTEPIFPITRKLAIDRSTTIIYFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS66</accession>
    <name>A0A914HS66_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS66"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3972.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3972.t1"/>
        <property type="gene ID" value="Gr19_v10_g3972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3972.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20078" checksum="4F88C2C5148A2CA3" modified="2023-02-22" version="1">MNFRASGEDRLELLNFKSREVREEQLKLRRETDVDYQKLAEDGIDEKILPSRIGEGARIGGCEGSVLTMIAGHGKGDARCPWRWVYPPNGYWTSGGLIKIVPTVVEICQEEKDSQAGQDDGKADGEGFRFLRFHGGRREGWLSWYADLSSNGAEGGDEEMVEEKEGDSGQHDGHGEDKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTA5</accession>
    <name>A0A914HTA5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTA5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4021.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4021.t1"/>
        <property type="gene ID" value="Gr19_v10_g4021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4021.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12818" checksum="6F8824261DF754E9" modified="2023-02-22" version="1">MEEVVEWLHTPRGDGLPKVLKCDFCPTELEGLITVFATATGPVNFVVTFCNCSDGIVPFELANILMGERLKLRRLDVDKWRLVRCPNERDEAVWAAWEAEAAGNFDAHEGPENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTH6</accession>
    <name>A0A914HTH6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTH6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3821.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3821.t1"/>
        <property type="gene ID" value="Gr19_v10_g3821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037908240" evidence="2">
        <location>
            <begin position="21"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3821.t1"/>
        </source>
    </evidence>
    <sequence length="615" mass="66894" checksum="C21CAB1DA4F93417" modified="2023-02-22" version="1">MLLIIIIVIIISILPGIIMAMPRLPADSSSHGGGIAAAAGDKPVEFDYDKWRSTSSSHSQLNAEQPDPASSPSSFIEQIGRMELVQSIMRFVERLGFGTGEQDDEKMTQRIERQSPATKSVEEQHREIFGKGRHFDSPMRANVNSVRSPTIRRISAKEQPQISSSIDSRPMTIAKPSEEQRYEQQRPATAAAQPQLNGMASFHEAIGKEWKQALFGRGGLLTEVFNFVNDKRKEDLAKQQAAPNLNDKASTEFSRIVDALLRKAKSGNFDEEPLPEIPFIGICNRLSCADIYKALDQKVTAISLLQDPKGLDMIGELLANPELIENFSGPESVGDLFGTTKKAPSKSGGGGGDGTRRAEIAENTDAENIGVDFSSMIDGPNNNSNVKMPPSIASSIDSAAPDYYSFTEDKVGSKADKLEDKTPKKEMVVTSKQRGGGVGGANAAKSVQSTKTSIDFSRELPEISESIDGGPPEDEDIPGGDMLVFEKNEWLPSPSSANSNGTTKKQQFVLTPLVDVRVGQDKKKVAAQQTVHVHATTQISRPRSKAAGGEHNRTTTTTTEKTSPSRARMQTNSSSSSTTTNRKTATTPPPVTTTTRRNFRRDDDYYSMYYDGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV14</accession>
    <name>A0A914HV14_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HV14"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4930.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4930.t1"/>
        <property type="gene ID" value="Gr19_v10_g4930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4930.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="30887" checksum="E1B4B8BF3D4AECF5" modified="2023-02-22" version="1">MSETKIIIGIASLCSIAAILATLVVVPQLYQQINEVNSRVFDGVQAFRVNTDSAWTELMDVQISVTPPSRPRENPFNSIFMRQKRSGGLPSQCVCQLQQPHPEDLDSPEAPDNLANSLPHALLLPPHAPLALLVSLDSQEARDRLGPLEAMANPDSLDKAAVRDHPVRPDLRGLEETLDSLEDLVSQDSQELPEQKALHRPVPPDPLDNQEETDSPVVLVNPDSPEDRDLPDLLVSQEDLDSQEALDSPETRAHLASLATTVLTVLVHLAPAFSLVEAVSKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX46</accession>
    <name>A0A914HX46_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX46"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4950.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4950.t1"/>
        <property type="gene ID" value="Gr19_v10_g4950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="2">
        <location>
            <begin position="550"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4950.t1"/>
        </source>
    </evidence>
    <sequence length="1191" mass="132887" checksum="7CEF3867D0EFB718" modified="2023-02-22" version="1">MEGMTLDLDNNIGKFVSSLIHTLTSITSLEEDVEEISDEPEEEQDGLNQSSISSSDPNLLNPVSFTVQHRFSAPPVAEVEDDAQQFRHRVHSLEKKMHEHAMLVADLANCGGVSELTLETERRKLRQLEQLHLREFRRLVVTKLKGHVSNTKQHDSQRKSANEEPQQRKATPRSHLLMRSLEGSSLAGGSSGGGTPRAQLQTQQGSTVVKELLDMNIDVKVYIECGKCILRADPSKQLQQLDKTSFLPGHRRQFSAGTTSMTVDSTTQLSLPSVDARFIYTSDDAKMPLPQQMEENFGFVKSYRSLNQKCFYTSLELASMPLTTLITPALIDFLDQTLDPLTSTIFDKSSIQKASSEIGSFDEKKLDPAVELIAIDRLGLSFDLILHVSVQASSLRFEGRQQKSSAADCLLTLPSLTLNGCTRKCCDGMDRPTIPHQQASAHDALSLTLDRLRVTASRTRNSSLNSDDPTASNDVRLVFKFEAGKAAIVHDMRRLDELISFPKAWYRKKLIKRLFLGQKSLKAPNTVATRKELSMSTEQSVGYRNLNSEKSDLNHSSAGVGTNWKALVDVTFDWEEMNVNAQMSTTMGFTTWLTKRGSTSVAVMFDSSRNRELGLRFELGSSQIVADGGVISGEMSINSLAISTKYSKFIEKAPEHNIELQVGLLQSKIEWMGRSIFIVRIIDQKMVASTDWSYKKSEDEEKVKEAHCFLKMDASWSDLDLIITRTTSGDFVKIGQKLRLFFKDQLHNSRVIWEEQFGGVDLDDDGSSIAGGGGSNSSSVGSNLGTLWHDVLDQLSEIQLHHKFLPLPDADDGITLVGGDLNFWARRISLACMDGDTTNAAVWALFHMVEPGIGISSRANYEFVSSKVADTSAAKQIGIALQQKFKFRLGNVQQRTHDGRDESRSEKCKAIICRVQYSRGSMLRHNSPIEHCVSALIGDVLAQLRDVVGGTVPSNASDVNEATSSSVSSAVVSPAKLSHNVLQLFQFAALNALLTNLQHQPIFEDGSSEDADNPKAKSDREDILQTVFSKFVCQFHDAVRIQTEFNAQLGFLPDLLRSYLHLQTDGLHKQQQQKDTFSRFPLPLSSSSAALTKSPKDQITLGRDDGAEMLKSAGDQRIYVCEEWDVDPKIQFIDRFKWNPPVIDDILKRLQIFDHRRTIPKVMQRSVFDRCDHLLFIAFSQILAQLRKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXV0</accession>
    <name>A0A914HXV0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative exosome complex component RRP41</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Non-catalytic component of the RNA exosome complex which has 3'-&gt;5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the RNA exosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5124.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5124.t2"/>
        <property type="gene ID" value="Gr19_v10_g5124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5124.t2"/>
        </source>
    </evidence>
    <sequence length="249" mass="27571" checksum="CF01FE60382ACB7A" modified="2023-02-22" version="1">MNVINEFGFRQDARTPNQIRNIVYQTGVYSQADGSAYIEQGETKVLCAVYGPHECRFRSRAKEDEAIVVCQYSQATFSVPDRRNRPRGDRRGNSFSHLLERTFESVIFTTLYPRSQIDMFFEILEADGANLAACVNVASLALADAGIPLRGLVSAVECGSADGLPCADLSAREHSELVPRLTLATVGGKDEIVLLDMKNLLHKNHLPSLLQLGIRACAQVHACLETAVFRHVETSHHKGTELNKNRFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZW0</accession>
    <name>A0A914HZW0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HZW0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5611.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5611.t1"/>
        <property type="gene ID" value="Gr19_v10_g5611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037712260" description="Hexosyltransferase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5611.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="41212" checksum="87BDB813B800265B" modified="2023-02-22" version="1">MGTNRVRMLLLMCMLAMLMFLLYNNEVPQVLNSTLNWQFGNNSTQTTSSLQQLYPADDKGGRHERRRQFLIRFKNIRLKYWMEFANACPEKTKLIMLSMARRDGFEKRKGIRETWMKDSLDQEQTKHGDLVFLHGFSDTYMHIHLKWYGGLQWQQSFCSNAEWVMKADDDSVIHLRRLAYWTEKKFRQIAVQHPLVYIGYIYFSPQPIRDKNSKWYISEDVYPLDWYPDFMQGTVYLATPATITAILLHSREIVGFYLDDVVFTGILAELANVTLVDQKMHFIWGFSYNEKHGQCEDGVPTALSMWGAGNLRDYVHHYGSTGCHVPRVTAIRLTLCARENNHAQLQLIDLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0A3</accession>
    <name>A0A914I0A3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protein NEDD8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Neddylin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0A3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g630.t1">
        <property type="protein sequence ID" value="Gr19_v10_g630.t1"/>
        <property type="gene ID" value="Gr19_v10_g630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g630.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10812" checksum="0F849C78638B336A" modified="2023-02-22" version="1">MKDLKGLTCFYRTLYKLIPMLIKVKTLTGKEIELDIEPTDKVDRIKEKVEEKEGIPPPQQRLIFAGKQMLDEKTAQDYKIQGGSVLHLVLALRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0E8</accession>
    <name>A0A914I0E8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0E8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6332.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6332.t1"/>
        <property type="gene ID" value="Gr19_v10_g6332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6332.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8458" checksum="5B2152D33D8533A3" modified="2023-02-22" version="1">MVNPSLIRFLVLSGQSASGQTDVRLLKSSKWDTVTGNFVVQIRIIDDLCSALNISLNKGVRRCQQQPLLENNKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0N0</accession>
    <name>A0A914I0N0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Snake toxin/toxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0N0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5519.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5519.t1"/>
        <property type="gene ID" value="Gr19_v10_g5519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035076">
        <property type="entry name" value="Toxin/TOLIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00087">
        <property type="entry name" value="Toxin_TOLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038000053" description="Snake toxin/toxin-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Snake toxin/toxin-like" evidence="2">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5519.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24499" checksum="CCE888381C4952A4" modified="2023-02-22" version="1">MVLKCPLLFLFFAFAQSIGAANEQIPLAAATALKPIQNSLEHNSTNVSMLCYYCRHSNKAHKDLSDPLIERSECLSPELFANQSQFQRQCAPNEGFCMTSVSSMNGFFVEMRRDCAERCRAGCQENGYGLFKRQCARCCRSPLCNHFDGRTFLLNDESVQQMPEGFNFGGADEDAVDSLLEHRIEKGLEKGENGAQKMATNPFGALLATFLEAILFVNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1V8</accession>
    <name>A0A914I1V8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1V8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g584.t1">
        <property type="protein sequence ID" value="Gr19_v10_g584.t1"/>
        <property type="gene ID" value="Gr19_v10_g584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002852">
        <property type="entry name" value="Dorsal Intercalation and Elongation defect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190:SF1">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g584.t1"/>
        </source>
    </evidence>
    <sequence length="794" mass="85320" checksum="D1D54D23EE6C624F" modified="2023-02-22" version="1">MCTGPPPLSPGVLHPPLSPAATPIRIRPLAPSLLPISPQQSSNDAQSSMNALAMMAAAGIGGGNAGGQQQQLFGHLLGSNPFPQGTAPSMMFTNAATSAAYGGLNSTEFDVAQGQHSQSGGASTATAQPTGGHQQNGMMSARGQTPAPSNKPPPQKRQYSSTSKNFCDLCNKEVCNKYFLRTHMLKMHNIIIDENKQLIANIDTADKERKGEVKFRCDICHASMNTRDELKLHKREAHGMSTGGGAQSTPLGSRGAPKTTLSTAATSTAGAMDTAGGAQQQKLVTLPPFPAPASHFSATMEHQQQTTQPPMSQLRTTPEGTAGANDENQPLGEQQTTRESAGGPQQSPLVGANPMKQLLSLIGGDETLPPSLVGGARLLPATNVVKKETDEQLGRTIADANNNATSCRFCGLYLEEEVQLQLHQLVEHPNEYMAALQPTLDLQQQQQSASKEDKLITQVALKMVEENSHHHHQQQQQLRKTSVASSGASSSSAASSGDIGTAHCTQQQKTKNGTAPRVEDGSEGGGHPCPQCKRVYKSVQKMERHQQTVHHNFVAKLSPVKRTIISPKKIAKLMTSFSCQKCRRRFATRQECDEHVISHIRLERLKQEGAETDLQEEEGGEEEERDRGPQVKRAKVEGEAEDSAGGGSLMVDEGEEEEEEVVAEQQRRTEVVREAEKMLSIGGGEEERQRGHRRTKGAGGEKHSHTSGSTSPVSVQAGSSGSGLPEGFAHPLLDHSKPFVLQSFTLRPISPHSNSQLPDELVAYLPVRSTLGQPIRVTFELSPTPQVDQQVQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I297</accession>
    <name>A0A914I297_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Groucho protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I297"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5947.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5947.t1"/>
        <property type="gene ID" value="Gr19_v10_g5947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF21">
        <property type="entry name" value="PROTEIN GROUCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="536"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="622"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5947.t1"/>
        </source>
    </evidence>
    <sequence length="698" mass="77293" checksum="704346115AF29496" modified="2023-02-22" version="1">MSISAESTNEGDIFQKTINSSTLSDDFDFVAQNGNELGEADTLGGQHEIEEEMKMELKEVKEELKQYKEELKGMKQLEGELKQYKEEFKLNMEELKQQQNQTEKIVSDQFLLMQSDQKALLDRIAALEQKQAANAEQQKADQKGLSATIHLSLLHHHHHQKQQQQPPFSGATPQGMNPLQPLGMNPLQPQGMNPLQPQGMNPLQPQGMNPLQPQGMNPLQPLGMNPLQPLGMNPLQPLGMNPLQPQGMNPLQPQGMNPLQPQGMNPQVAQPQQQLFQQQQQHMTAMARQVMQNNDVQLLMSRFKEATQRGPDDVEAFFVELRKSPHLLNAFLKHTKKNVNLPGALPVHQHAYAFKMCPGESMMPALFPNDASPHGADVPKSLKQIGDLPHGDVICAVTMAQNGRHVFTGGRGTVKMWDIGERLGLVASSTAAGGTNGGRVGTQPWSPVNTFNCLKDFYIRSCKLFPDASTLIVGGETRTICVWDLNSEKVKTTLDCEAEACYALAITPDCRLCFSCCSNGSVGIWDLHNELKIGQLDGHTDGVSCMDLSADGVRLWTGGLDSSVRCWDIGERAELNKYTLESQIFSLGCSPTNDWVAVGLENNTVEVLHMNNRQQQEKKYVLYGHENCVVSLKVAHSGKWFVSTGKDSVVNCWRSPYGYPLLESKESGSVLSCDISSDDRFLLTGSGEKKATLYELSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3W8</accession>
    <name>A0A914I3W8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rab5-interacting protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3W8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7268.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7268.t1"/>
        <property type="gene ID" value="Gr19_v10_g7268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010742">
        <property type="entry name" value="RCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906:SF0">
        <property type="entry name" value="GEL COMPLEX SUBUNIT OPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906">
        <property type="entry name" value="PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7268.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14575" checksum="CB77BDDB7FFCC870" modified="2023-02-22" version="1">MSTPKRNGQIEGDGKKQNLFECISKALRRRSEWSDKDELLDVLYWGRQLLSLCIGICWGLVPMKGAIALLLYVLISTAVGHSYMTWFQEQDDEEFGGFWEISKEGFGAAFATFMVSWITVYSTFHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3Z6</accession>
    <name>A0A914I3Z6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3Z6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6386.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6386.t1"/>
        <property type="gene ID" value="Gr19_v10_g6386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41349">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41349:SF1">
        <property type="entry name" value="PROTEIN CBG08683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038137978" evidence="3">
        <location>
            <begin position="19"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6386.t1"/>
        </source>
    </evidence>
    <sequence length="851" mass="97402" checksum="868BB7A2F8187022" modified="2023-02-22" version="1">MYFQPILFLFTSFNIVYGEIPQSNRIIMRILTMNTWHAGQHVENGFSKIAKHIKALNADVVLLQEMNAKAFDHKPAIITKHKIIANTKFFTNWTFGLTIFQDSGITLNVVNMHLNYRNYGPTLVENAKTGVTAESILADDFQPQGRLQNFLELSSQPSFKKFLAQTSEVPLILAGDFNEPSHLDWTNKTCHLHKGFVMEWPVTKYLSEKHGLVDTFRQLRPNVLETPGRTWSSVWDEAFEPSDRIDFIFYKSDQLKPVQSFTYSGLEALKKLPEKDRWVGIEELEERDWSSDHYAVVTDFVMDNQFRPRYVGDRWNGCNVKENGTIILENACKRNKILILCYKSNKATGQNSKVSRRFRSKIGLYWEGLFDKCAGVMGHKEWHGLIIDKMADGKVAFESSLRFGGFFANDLINKTVAFHIFSKADTLLENDFQMALRLGAFMDDFDGMALRILALDLVSVTEYIGCQMMCSLPNSDGTEPTTLAFNTPDTQNAATEEPRTPILPSSTASEIKALRKWSRQCEDNNISVKEFKSLFQATEKYLIAGGLTGTCSGLGNQMFRFAGLYGIGKPYGRIPIFLKRQNCHRGLEAHESEGVDEMDRLFPNYAKYLKFSLSTFVSDRPSETRVLKDFASHCCRYDDPKRINFTSFAEKFVSIEASFFQSYKFFHNIRREIRQIFQFGRPICVQMENFKKAFFSVSDQNAIKLCVHTRIGDFAKSAAHFPSEKIFTEKAIEFTYKHLTQKHQQPVAVVLFGEDKNFLANLSIDRKLIRSIYTPKAMSRAEDLVFVSITCDSMLITSPSSTFSWWMAYLMPDGATVFYSTKLEGTYYTRENFLPEWIPLKLKGTGTIAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4V8</accession>
    <name>A0A914I4V8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Cyclin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4V8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10995.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10995.t2"/>
        <property type="gene ID" value="Gr19_v10_g10995"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6824.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6824.t2"/>
        <property type="gene ID" value="Gr19_v10_g6824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20532">
        <property type="entry name" value="CYCLIN_CCNL_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20533">
        <property type="entry name" value="CYCLIN_CCNL_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="96"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="234"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10995.t2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6824.t2"/>
        </source>
    </evidence>
    <sequence length="502" mass="57938" checksum="E10C17B4E7EDEF1C" modified="2023-02-22" version="1">MFEAEKSNGTNAVALSPPAAYKVTAQSEKSALDALMAKVRASSYGQLRNYSTIDISAEKWLMHYDAASLAKLENPPSLADGISRELERDIRYLGCELIQSGAILLRLNQTAAATAQILFQRYYYLKSFVRYNFEHMVQACLLLASKIEEEPRKPRDVLNVYNRLKQIHHRRCAAAAADQHPEAVQKLAKKFEHLELCSKKYQELKNIVIKAERRLLNVLGFVVHVHHPHKLIYIYLHILGQLKNDSKKHTEDEIRKSRQLLQKAWSYMNDGLRTDMFLRYTPETIACACIQLAVRTVEDTIVLPKEPFAWFELFDASDRDVRAISQMIWELHTRTKAPNLTWISDHLDRMYQKSVVEPEKARKEKAVEELRNIKEKILQRKAAQEIARKAPSPPAAKRHRLSPSDNNHHHHQRSKKQQLEEERRSSSTSAQNMTMLQDNRRQQQQQQSKKSSSPSSKRHSSSSRKRDRAGVRDSRRRDDRGGGDDHGYHDHKGINCQTAQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5I0</accession>
    <name>A0A914I5I0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Forkhead box protein fkh-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Forkhead transcription factor family member fkh-2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Transcription factor. Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein pes-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5I0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7509.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7509.t1"/>
        <property type="gene ID" value="Gr19_v10_g7509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047208">
        <property type="entry name" value="FOXG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="162"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="162"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00077297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7509.t1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49516" checksum="40DF003B216365C9" modified="2023-02-22" version="1">MWPKIEIFARKNWSCDFLGRPFILMIRPTWKRRPSKNETLITEQNPRGIFQLLCTPSAGDEQTAGKRSNEWKTNSKNESDDGQLKEDDENRRAEAKCSSTSPIEAATTTSSDEAKSGLGSSSSSTSMSKGTELELDLDDLNTTTSAEEGTEQGKSVPNRHAKPRFSYNALITMALRQSPGGRLTLNAIYEYIMNKFPFYRTNRKAWQNSIRHNLSLNKCFKKDPRPYDDPGKGNYWMLDPDFKDEIFIGATTGKLQRRRRPNAIGQNYHHQHYGMLRKGVAALKGLNNSRPAAADQHQQHQCRQLQQPGTFLTPTSSQPLLCQPDGANLATLSAIPAKMMHPNSAFIRPPFFCLATQSPPPPMGQMTPSLSMVLHPPLLTSPLFPHQLIESHAQLNPNEQSPQHMVLLQLIQRAHQQMIANQQQQKMLMEITGDGHSSTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5R7</accession>
    <name>A0A914I5R7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5R7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7768.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7768.t2"/>
        <property type="gene ID" value="Gr19_v10_g7768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7768.t2"/>
        </source>
    </evidence>
    <sequence length="299" mass="33202" checksum="DDB544574DED1734" modified="2023-02-22" version="1">MEQIAQQPQHKIRQKKRKKLGKHPKTENVLFFSTHPSQQMLDNVGLLPEPREGPSSSSTPSLPPPYPSSPPATTTIHHLLVSKSPYRHRYHHHHDHPHPSSPPFSSLSSSFLGPSLPRFHFALVLLSLCIISVTIICAFGCYFRILNEQRRNRRQRRQPNACRGDSSSNIAEKERLARVNKFIVRSSNGTTSTLTNGPTSTSRVQQQPMGANAYPQRIVPKITITSSGSECDGAAIFGHLSATRSPKAQPLEKEIGRKNDEILAETAVDDSGGAAVGRMRPEEFIQTMLEKVERERGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6Z4</accession>
    <name>A0A914I6Z4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6Z4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7486.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7486.t1"/>
        <property type="gene ID" value="Gr19_v10_g7486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF25">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="8">
        <location>
            <begin position="38"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="302"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7486.t1"/>
        </source>
    </evidence>
    <sequence length="587" mass="64832" checksum="095858380E5C9FD7" modified="2023-02-22" version="1">MDDQLENAENISPNSSSTINEFSAQKNSFFCRYVEPEVQTTKIYYYVDDQHIPFSTEIPIPPSKITLADFKKYITRRNYRYYCKVMDPGLNAEVKTDIRDENAVLKPNSTNGRFELFLLSETQTHSSASTLPIQQLQHGGSIRASLMGKRASAHYFDGMPNFIDYSGSTDEDSTNLRLLGESNFAGITGSLSDGDSQYTTDFTSVSQQNPQLPRRTFPDLHQPYKNGDNDGGGSRGGGGTGGHGHHHRHHHRPKFTSSNKRYDSNNKPCWTREKRKRTRRKSFPALSSTFDDTTEASMSLEMITVTFNLEGRRPFGMSIVAKSNRSGFAGIYVHEVNPGGLVALDGRIRPGYIILEVNDYPLDDYNSEDALDLIISSVKRATETRGQIKLACAPCSESVELARNIFHPILGEPVRPIDPTAWVQHTNAARGLNQQQKQNFVIVPQGQLQQPPPPPRYCLLPNQPNLSVPNKSATIPKTNPQQPNKIVGQTNAEKQQQFAVDTNCCVGGGIRMIQNPATDITTTESGASSVECSVGQFAPNAGKGEASAGRKRGKAETKKKSGGGIGTALRRLMCIRTSKRGNKKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I742</accession>
    <name>A0A914I742_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I742"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7912.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7912.t1"/>
        <property type="gene ID" value="Gr19_v10_g7912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7912.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9078" checksum="F2324B3AE6DEEB0B" modified="2023-02-22" version="1">MPTIFEIKSAELKEDVNSYFVVRAKIERLEYCEYLGCVFCRKGRCQCPEDKENFLYLKLALADETGSLKLSDLSVLCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7B3</accession>
    <name>A0A914I7B3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7B3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7417.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7417.t1"/>
        <property type="gene ID" value="Gr19_v10_g7417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7417.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33449" checksum="A26AA9040E0C1208" modified="2023-02-22" version="1">MRKAMDSLYKLVDIGANLSHPSFQNDYADVLNRAKKAGIIKLMITGASESITEDASRLASQEPGFLYYTAGVHPHDAKDFVEGRTLDVLRSHLAENRQCVAVGECGLDFNRNFSTRDQQIRAFEAQVIFQRSNWPVSLANRCRYSASLPPTVIHCFTGTVAEARHYMEMGLYIGLTGFLWKDRAEDGVKRALRERTIRIDRLLLETDAPFMYPKLDDKKLDKDIRKRITAKALELHQHSNFKRNEPSSLAAICELIAAYMDYAPAELANATTENARRVFGLDILEQYNDVEVVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7C6</accession>
    <name>A0A914I7C6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7C6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7974.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7974.t1"/>
        <property type="gene ID" value="Gr19_v10_g7974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7974.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21569" checksum="CDD8B2B87AC771C0" modified="2023-02-22" version="1">MLAALSYRPQYYVSVTPQGTDVQQRQKKGRPKLFLSLQPNKTTFEQFKLFKQFKLFELFKLFEQFKIGVHSWHKACGLFRFGSVVKEGDDVVPFELKNNWTGERLTFRRIGGYWLLVRCPIGREEDKWAKWEEEAITYELYRQWNFIYITFNDRDIGDGMFDAKAGPSDPRSKWTDAGDKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8B0</accession>
    <name>A0A914I8B0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8B0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8216.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8216.t2"/>
        <property type="gene ID" value="Gr19_v10_g8216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8216.t2"/>
        </source>
    </evidence>
    <sequence length="181" mass="20028" checksum="7D9E79C85F0E4C55" modified="2023-02-22" version="1">MARNVLSSTAYRQLDVDAFDPDKFIDGDEAETPVGLGPDDAQVRQLLQSNQNIDALKAALANPPLRTKNQVLKDKATSLVVRVLTSFKSAEMETAVKSLTADEMDRTALHCSHGMRRRSMFVAMAALCAFTTTDIDFDGGWTGWAADATLFRPFTTAVFFCFIRKSEAQKHYEKEAVNSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8D5</accession>
    <name>A0A914I8D5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8D5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7678.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7678.t2"/>
        <property type="gene ID" value="Gr19_v10_g7678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000104">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="549"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7678.t2"/>
        </source>
    </evidence>
    <sequence length="585" mass="64216" checksum="4A10875AFD64EAF9" modified="2023-02-22" version="1">MESTALCPQLFHQKHPGTAKFFVSSPASDVDSNTKTFASNGPPIRVVIRREKRSPNDAQNALPTDFGSLLDRSSCNKRFGPSLNHRLAGDAATYLGSPLKHLVDADLSNGSNLTHPTNATLTSNDPSLATSALLPAHFDGTLDPLFSPPPAPMVPVLTAEDGNTLMSAGDSNDPPELRHWANIGESNAFQFLHQLENELRRSPPRSLLSPDNLAAQSSESNCPQPKRSPISKKPNAKRRDRRRSSAFVPSARSKEELESLLSTNIDPNKPVRNVLVEAGIGAEFGSRLKSSANSMVASLPTVFCNKFPPSLEGRKRRRSAGKGRNATETEIAMGHKNGEKIAGQRAGSISCPSTARTYSTFLVASEPLTTIFPTPPINSGMLACWPNSDHLQTNEGPTSSSSSAAAPLSEEQRKMRQNGSGGAQRIDRALSNSQLFTQKIPCSYKGCQKTFAKQSAMRKHLQIHGPRQHICQQCSRSFIERSKLKRHLLVHSGEKRFVCDYEGCGKRFSLDFNLRTHIRTVHTGERPFQCLLCSKQFAQSANLRVHRRSHNCRPVSGGGTPKKRRTAKERRRMLNARRLQDSTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8E3</accession>
    <name>A0A914I8E3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8E3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7594.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7594.t1"/>
        <property type="gene ID" value="Gr19_v10_g7594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7594.t1"/>
        </source>
    </evidence>
    <sequence length="387" mass="42061" checksum="EA4E3DD50B8874C4" modified="2023-02-22" version="1">MGWGTKGLNRTNDFVSESAVFAGPSTEEEVGIGTLQKASSLSASSSEEKSAMALWLRGRHGANGQSARIGLTGSNNRTKLELRDQRDPKQILDNHKTLLEDVEIYRSGKHRQLLNVSKRESHVTNTSGDLPMRIDGVKNSSGGFAYSLGWDGPPRGHRPANLSDPWKGGHQQRQKRDREVPERAVEAEPGEDVPEERVETVSDTGTTSAVVPNDLIVQHGHVVTPNVGGAVFQEARIMRTDPPPLQHSPHRAAWVSTPSSSTSANIGHSMPMPKSELSSSSSSSSSSSSNSEEEFTAGRNGVETNNAKMSWPDFLARTAKEKQSMAKSERSAENDSERQMDDETWHGGELSGEICAAILAFMVVFTASVCVGRQKSLDKLKKAIEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I916</accession>
    <name>A0A914I916_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I916"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7833.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7833.t1"/>
        <property type="gene ID" value="Gr19_v10_g7833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7833.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29070" checksum="0F4F167C130AB3C0" modified="2023-02-22" version="1">MSNVQQQTATGLAAEDEDSADEYVVIQQEEETDSGKSSTKSVSTAMKTESVPSDAQSLTPSVGTLGALADIGDGLDGDKLSVSAVSPRTAMNESSYSQNIFNSSIFGSFVVEDQLRELVRSENEQNRQVLDSIKNTLGELSKQKSNNNELNELILLHKMSLEKTLEEMVHQLSQERDRSTAMVAKSKEEVASKDEIINVLREELDDQHGMHEARVKVWRERMDSLERMLVSQQERAEADVITPSKSDSTLLICEKCLNAFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I934</accession>
    <name>A0A914I934_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I934"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8635.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8635.t1"/>
        <property type="gene ID" value="Gr19_v10_g8635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8635.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9005" checksum="94B173B57FBF0B16" modified="2023-02-22" version="1">MDSADRHGPANLLSDGQKPSTVRRTRFKIVESIQIYSNDAMPPPELLHLLLSMDFVVVVVMPWQPPVAKGHKSNAGSNLSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9D5</accession>
    <name>A0A914I9D5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9D5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8714.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8714.t1"/>
        <property type="gene ID" value="Gr19_v10_g8714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038101059" evidence="4">
        <location>
            <begin position="29"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="836"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="128"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="220"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="317"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="427"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="528"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="626"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="724"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8714.t1"/>
        </source>
    </evidence>
    <sequence length="961" mass="107362" checksum="3423B04190113A98" modified="2023-02-22" version="1">MFRLLSMGGRLCALLPVLLSNLPNTSSGAPLRWEWEPPASTERSEEETADLHCPARGIPPPLIRWSFNAVPFHEWTEDGRRILLDGGKLLRIRTLKRDLDTGLYQCNATSPEGTLAAATFLNVQAFAPHFRHSAHRVWKVLRGTSVDFPCDVRAAPKARVRWVDANDTAIVGVKGKLEFLANHTLRLNDLSSVDDGFYYCNVSNRYGINRAMNRLEVFNPTYFAEVPQPESLTRDAFESVEFRCRAVADPRLTLEYVWTRDGKRIEQNARTDADGASLLQLNKLRGRNSGRVECSVVTDVDAKTASVHLTVRDVPEPPEVLRVDCSSGQHALVVWRRRAENGAPLTHFTVDALGTRERNANWQKVWEEKVGEEKAKRAMFKAAIPLAPWVNYTFRMFAHNAYGASDPATAPVALSPCATPPDVPFSNPSAVLVQGTEPDNLVIRWTPLARNVWNAPGLKYLVRYRQMDESEWHEFFVEDPFANHTIVREQPTFRPFLVQVRAVNTRGFSAVEPETEMGWSGEDVPLEAPRNLRLVGHQNHSTAELEWEALLSESSVRGHFRGFRVDHWPSARPFLITSQIVPNTSTKATISALQALTNYGAKVHVLNGQYISEASNLLTFKTIEGAPSKVHDLRVHSVGSRTLLATWEPPLHPNGNLRGFYLAFENLSSGIAEETFVLRRQLFYLHELLSPETPFRVAVWAETGGGEGPRTWRHTRTWPLREPDPPLFSIRSLSPTALRVRWLPSGNTSAVHWRMSGSSFLLNYTKKGSSEWHQTVPIVLPQTVLDVRGLAEGTDYVLIGEAREGPKRRRQSVPVTVRTESSRAMPPFSRERLRSAAWFLAVLIACALTFALLAVACVVAQRSAGGIPFGFVALRRREKRFGPALRFRTPSSSTGEEELGPEGLDWLSEGGDAHKRFLLEAQRRLSGALDDKQGQKQLKKNSAATKTADPPGAKDGKIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9K1</accession>
    <name>A0A914I9K1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8548.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8548.t1"/>
        <property type="gene ID" value="Gr19_v10_g8548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035060">
        <property type="term" value="C:brahma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021906">
        <property type="entry name" value="BAF250/Osa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033388">
        <property type="entry name" value="BAF250_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656">
        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656:SF5">
        <property type="entry name" value="TRITHORAX GROUP PROTEIN OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12031">
        <property type="entry name" value="BAF250_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="474"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1047"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1255"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1299"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1681"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1842"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2169"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2284"/>
            <end position="2388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2438"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="644"/>
            <end position="669"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1047"/>
            <end position="1064"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1080"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1179"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1264"/>
            <end position="1278"/>
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        <location>
            <begin position="1306"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1701"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1857"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1882"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2284"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2310"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2352"/>
            <end position="2361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2370"/>
            <end position="2387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2441"/>
            <end position="2452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8548.t1"/>
        </source>
    </evidence>
    <sequence length="2499" mass="269288" checksum="5D6E1D5FDF222A54" modified="2023-02-22" version="1">MSSKESANNGHGTSVTEQKPGPSSTAAEEQQQQTKNTTPARSPALHFNAGTPSSSAATATELSSPAEQQQRSAAAAAQAPPSSANGGEQQQQQQQHYQRWPGDVSGSSPAPPPPSSAAPPGPAAPVLVSPHYSLPPHIQQQHQQYQQQLYYGHQGTPPAGSQHSPGQQRHYAPAQPPQMLHPGMMYPHHPHMVPAYQQQYGAVQQQQQQAMAAAAAAYWARANGQQQQHYAAAQQQQQMPPPPPQQDALPSAPSSSARHTPQPSAAAAAPPPNPSPVASVQPPVQSSPSTAASAHGAGYDESAAAGATAHAATAADSTSQQQQRPRSRQQNQHQQQQNPAAPQSLMLTPQAAAHLRYSPAGLPPGMAMMVPSGPHGQQQPFPSPMGPPSHPQHMAFQMHHHYPAQGPPPPFPGPPPHPGIYFHHPAVAPGAAGASGVHPQPGLVLGLKPAQREAVEKLVMQLANTKQQLTADLVHERRLFFERLVLLNEQQGEVLSGPPQVSKSTVDLFSLYFAVKKKGGFEKTIKDKVWKHMCVEANADMQESSAAGFQLRKHYQKFLLKLECLETGQNAKELVEFAEKQKKKKKEKEPSSGGGAGSAGGPSTPSSSKDEQQQQQQQGASVGRPSSARGEHRDGAAQQQRQKGGTPNSGGTNSSTGSGMLQQPQQQQQFGGGQQQQQDRRSGKQTHRTPFFVSLLQQPFPAASLPPPHCWWTVGSRGGGATAVVAVQQQQQQDELAAKGGITTTTAAARMSPSTTALAFGNGGRLLLHTPSPSSSTTTTTAAAATSSTASTLSPAGTMCYVGGGGGGVARERSLLPFQLNPARPSSNPATALTNWHYQQPKQFQQTVPSYPRYGGQPPYPTTNAAAASVAIGSDYLRNVPTSSWSVLPNYPTMSPHLQQQQQQQQLQQLHQQHYAMPTSSVRVVQPQRHQPVMVSSTAASSLMGRHYHFYASAYRNHPSFASSSSSSPLSLCSPVSVAAAQPFFHQKTVVAMPPSAQYPPAYRPSLLVSSHHNSLQNYYGLALPFRPPLRARVPTLPNTRRRRRLANTNRRNGPAFQQQQQQQAPQGMYPPRMAPPPQQMRQQQQQQMTTAPQQFGTATAAGQADDEQQQQQQRLQSTSASSRLSTPVPQTTTTDQRPISRASSSSTAPPVEQQQQQQRTTADPQQDERGEGAGGTVQQQQQQQQQQRQAQTPSAFSANAPTPPLTTSTATSVQLTPSVATATAAGVVPFYHPNVPPYGVGRFPSSANEAMYGTAAGPYTSSQQPLPFAHQQQQRYQQQQAAAAAAVGRYYPPLSGASSAASASIGTPQSAKSGASSTPKGFPNGQQQQIVPSAFYASGNRASATALLGVVPPPPAGILPSSIGGPMAVPPAYGGQQQQQQPLYAMPTSSTMAWHAAVFQQHHQFPPHSLEAHTIAQVQQQTKRQRDKVYARDLWGATPARIVMALRSALHTETVWALNALNVQLYDDTSLSANAAPSLAQTPELLNLLVDHLAATLSLLFPDHFDTKTFGGRGQHRSPNSNHRISSSNATAAAATSSFCSANGICAAATNSSSSNGSSLLVPKHESLVLFDKVEVLVPNLPLTTTPRGTFVMTPNGRPQQHRQQQQPQQNGIICTTTNNSNNFTMVSRLGRRVKLDSAAGEVLPPALVRELQNDGEAKDEEVPFLHFVERVRQSVLGNVRGAGGEPRRRANGFGSKANGAEEERKQTKEFWEKEKQQELKKRGETAEEIEEESAVPRRARLFLHRADDGDDSCSCNRWHINNSKCNGSEHFTLLARPVVLQDAHADERMGALMEQCLALANILRGYAFLPGHERTLGAHGKLLRLLSVLMMLMVDGTERKRKTNTEQASRGKQHHSPDIVLKMKDEETEQKHLAKEEQQKQQQQQQSSSEGISSDMERAVEKATDDMAKPQQQTAAAVPAEVDTPRKWLLEVANQLRDDAFVIMAQLSAHLDLFDVDSAISWPIFDALLHWSVSSDVQARDPLPPFGAVSPRHYALEILCKMSVMERNVDLLVSTGSWLRLEAFVRLLCAQICEEPPVREFAIVILNAVCAASEPACYVAAVETPLLEHLVSFLEAADANMTQIVQQQGMHALRENPEIIGTSVGMLRRATTIMVQIAKHEQCREHFRRLQHRLLQFTVSHFMDLRVAAMVANILFEIQRDSVSAAEAKRGGGESGGTTTTADQARKEGHLPSGPPPVVGEDVERKATECLAPAPFMLGSDRNALFNGTCNVSFNQQQQQQKRQLELLPLRLAPPHPITFAAAAATVYVPPMVMVKQEKKDENANACGHDHVDNDDKADTNKRKRVHSNNNSNNNNNNHYDESNGHAGGGGRRTVTRTPDASVGSVDELPVEKRPRMNDDANTPPPMMSMNNNNSTTTTTTTTSSVKVRERMRHNILSKKASLKAAAASAEVMAASPLHPKRNGWIAAVGAADGHCDEQQQQQQQQLQRQQTKKMLHNGIGTESGKSGEAMPTQNASTSPAASSGGGAGGSSLTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9N1</accession>
    <name>A0A914I9N1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9N1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8180.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8180.t2"/>
        <property type="gene ID" value="Gr19_v10_g8180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037448779" evidence="6">
        <location>
            <begin position="23"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="69"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8180.t2"/>
        </source>
    </evidence>
    <sequence length="335" mass="38308" checksum="1CF2DAB1067937AE" modified="2023-02-22" version="1">MIYLKIYLKFFLAASRLFLVKSQVLRKEMEFISNNNLPWVEKYRPKFLDDLVSQEEIVKTISKLIDEDKLPHLLFYGPPGTGKTSTILAAARKIFSPKNMQSRVLELNASDERGIGVVREKIINFTSSQGLHDMTSSKGKRIKLVILDEADAMTKDAQNALRRIIEKYTDSTRFCIICNYLSRIIPALQSRCTRFRFAPLSQKEVLPRLNHIIEKEHLHAVTDEAKNALFKLSKGDMRRIINILQSTALSAPAEIDEDSDIFRVLLDNSIEIAYKKLSNLRLSHGVALADLLEELVELLRPLDLPDESLALISAFFEARKLAFDKFADVQEDMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAN1</accession>
    <name>A0A914IAN1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914IAN1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8426.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8426.t1"/>
        <property type="gene ID" value="Gr19_v10_g8426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="51"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8426.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38074" checksum="E453A55BFE8BD7AC" modified="2023-02-22" version="1">MSLQTNNRRAATVVAQQQQKRGTMPSKSKGRDRNPPSQPPPQRTLRSIYDFKDVRGIGSGAFASVFHGFEPPSNRNVALKRINLTEIDMDSVLYQSVINEVNIFKTLNHPNIVKSFYSFEELSRFSGVKYLVLVLEYVNGGDLETWLNRKTNDHRLLVPEADIWRVFTQIADAVQYIHKQHIIHRDLKPPNVLLTTEDIVKLTDFGLSRQQNAGSRVQTVCGTPYYMSPERILEESYTTKSDVWSLGCILYEMATLRSPFFGEKDNISSLMQKIRDAEYPPFPDRCYYTAQLELLVQLCLKPVYKERPNAVDVHRMAAKMAGHWGVGGGGATTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICQ1</accession>
    <name>A0A914ICQ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICQ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8993.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8993.t1"/>
        <property type="gene ID" value="Gr19_v10_g8993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037271944" evidence="2">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8993.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21785" checksum="A623C06EC66486BB" modified="2023-02-22" version="1">MFSTATIFIVTTILSGVFVGIFGNPNEEDGEDEGNYQSNFVDFENSDDILPTSHVFAALTLNPRFKSSAFASRSFNEQSLLRKSLSLNVPKPMNASDGNGRNNLVISRSQSLNIERKERAKVYKELDHWFGKKKQKNPESDERMRNIVANWRINKTMAGDFMPLFKVRELDAKKRTSRLSDQKDKMPKANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICZ1</accession>
    <name>A0A914ICZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Wiskott-Aldrich syndrome protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8747.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8747.t1"/>
        <property type="gene ID" value="Gr19_v10_g8747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WH1" evidence="6">
        <location>
            <begin position="45"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="5">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="7">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="7">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8747.t1"/>
        </source>
    </evidence>
    <sequence length="627" mass="68641" checksum="661F5A1DBF20B791" modified="2023-02-22" version="1">MSAPVSRNRNSNSISNGGAKKKDQRPVQKGSTLLSAEENLQLFEVLGLDRISLAAGVAQLLSAYPERPNIWRKVNVGVAYLMKDYRQKCYQLCLYDFFKKELQWCQILYKNFAANYYPNSPRFISFESDSCVNALNFSDFKEAETFKAALEKWRVSKNKKKSNQTRRGSAGTTVLPSQHNPPPYTSQINASPVIITTPHHLNGVHCQPNHHHQQQQHPVGITSMGAMPHFVDKSLHLSAAKTTKKSGKAGKKRRERVITKEDIGIPLNFVHKAHVGWEGNTLSTNGCDVLDEEFVKVCKSIDKEPAKMDRDELNHALKFFAENKDKYALPIEPLGSSSYQRSISASNSQITQFLAPSTPTTTIRHQPPPRPPPVNNRALHSMGEFKTRQQPIMAHQPVAAAHAIVLPAPHSIVPPPPQRVLGASLGAGVQQRPQSTMTSNNRGKPPPPPTPPTVIHQQKNSPAVSAESTALLPPPPPPPPPPPPPPPPPPPQSKPSMADTALASTSSDSKLPQGGDGRANLLHQIQQGTKLKKVGSPSADRAPVPTNPPTMRDTMMEQIKQGTTLKHVDQAEVENNRRSGGGGIQDIGGLAGALARALEERRRNIVNSDSSDSDSETNNDEWDDDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDP8</accession>
    <name>A0A914IDP8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8935.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8935.t1"/>
        <property type="gene ID" value="Gr19_v10_g8935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="238"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8935.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35395" checksum="D0FC8A85975452E2" modified="2023-02-22" version="1">MNVTNWQLQKQQQQHQEENNNFPDCCCDEGQSAGPPPPPPEGTISRADENNYYFDNNWRPLLHDGQQILHTHLNNQQQRAVHCDGGGIAKYGDGQMMIGGMPKMKNRNIHVVYSSIGHTQIFTNSVRADTTLCAIPSTRTPPEALLYCACTPTSSEAPDLCGRQQEKALLPRASLSSSSLLLFTEKTCAWHRWIDQLLQEVRCEICAERLICIGRSTMSSSACGSSHCAFGTSSVNFEQLLKRKREQNRAAAQRYRHRKHCRLEWEQDEVARLMEQNEKMRAERERLRANIAKLKAQLSTLNGKDKNGKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEF4</accession>
    <name>A0A914IEF4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9460.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9460.t1"/>
        <property type="gene ID" value="Gr19_v10_g9460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9460.t1"/>
        </source>
    </evidence>
    <sequence length="847" mass="99283" checksum="6A88285AE5FC2DF5" modified="2023-02-22" version="1">MNKQKLIKIFYFISFNFLLLYAKLPETLFGIKLRSLEDEYVRLLFDQSLDLSSRQMLSIRLSAVQLCIDIDRALNDSRITKLANLEKKNKKKNVKLDLRTEFDQLSSNISQNQILSPVDVCRLWEFQLLLNDVNQALNQNGIFIKKVKAVNKIYDCNELKNIEGILPIWATDFKKNITLKHFTFISSKLSSDFINMDFPRWFSTERFANECELLYRFRIISAGGDFEQTKRVKSVLTKFLLSNQEVSLLDMFYPLEIAADVLFEESFVTLLLGLFDVIPEQKKLKQIFEMVDEHQKIMTSKIWDIFEVLVNINPNVYDENETYKTNLYMECPNDQVVYHLDKIDQNEMAEDVGAYTLMQSYYYLMGKVGNSQQTKQIKKLLQKLEMDAAVWVYKDLIQQELFEFATFLDVRTDEFDAIIEQYTFEWYEVSTTGGQSVYNALCSIHQFAQTIVENTILMQNVGWNLHVKSLLETPTSFYDTKLILLPTEKDNDLAKIDCSDGKLASKFMKEKFSWIVPNVVFETVEATFPEIMKYDSLLDSQYISLLVYRLLFKSGTNFAKFYEARIANHFIEKDINDAFEDQRQLLNVFHFGYLARLMQDNEFLKLWDQSVMTTDVFNDNKILYAHYNCFLFGELSCASTSKMGTLLLAELILFVRWVENRIGTARHTIANKRMANNWEKDKKQLENIYDQIYDEEDSAIMLIRFHFSECMLDAKLYMEQYKKWMGSQHKDVIFKLIKEDEAFVVRLKSVYESEKALFKQDLSNLVDTAENSNLNEIFCMDASENCHPDFVGVKLSSFEDNNFLAKHFEKLVETMQNDSVDPSINSNVQLLHFGIYANEIFHRIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GP17</accession>
    <name>A0A914GP17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GP17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10101.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10101.t1"/>
        <property type="gene ID" value="Gr19_v10_g10101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10101.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18229" checksum="607F2657FD9C2F2A" modified="2023-02-22" version="1">MNNNTQLQQQQQQQQRLRALDMDKWDINEKSDELAYRFDVSGFRPEQLTVELHGDEIVVKGEHKEQKEGLSVHNRFSRSVRLPDAIVRESIHCVLEDDNHNNNNASSARLCVCGKRQPTQEQQQQLKEEKHKVNTCTIPVKVVNDESKQQQQEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQK2</accession>
    <name>A0A914GQK2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQK2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10485.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10485.t2"/>
        <property type="gene ID" value="Gr19_v10_g10485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10485.t2"/>
        </source>
    </evidence>
    <sequence length="690" mass="78461" checksum="6C226E31C12D392B" modified="2023-02-22" version="1">MKPPHLSLRGYEGKEYLEKDINKEKTDYAQTWIVPGWRGQLIDSRQSPGDDCGFFEDQSECVVNAKKEKRYKKIRDVRFKKWLRGEVPHIYEPLTDYLKSVHAMNVCSTVLSVRNCIQLSSLRLYTSLTIHSRSWKEGFFKHGKFLRHLPDGVKPTHIVVGAGSAGCANRLTENPNNRVLLVEAGPQDHWWNWKIHMPAALMYNLRNDYYNWMYFTTPQNNMNGRVLYWPRGRVWGGSSSLNAMVYIRGHPMDYDRWEQEGATGWAYKDCLPYFKKAQTHELATGPDDPYRGHDGPLFVSQGKCEHPLHQAFLESGKQHWLGGTEDMNGYRQEGLGKMDMTIKDGRRWSASSAYLSNILDRPNLFTTTGITCTAVLFNQRRAIGIELIRYQRFMLTEGVDAYSREKIYCEDSVILCAGAINTPQLLMLSGVGPASHLKVHQIPVVQDMQGVGRNLQDHLEIYVQQKCTKPITLYNKSTWRHPHRMAMTGLQWFLTKKGLAATSHLESGGFARSSPEMDHPDLQFHFLPSTVHDDGRQDPKCHAFQVHAGPMRSKSTGEVTLQSNDPRRTLSSFAEPFVSLESFLRRRLLTNSEAKNWLREKNVRLIIRSMLLFAKTLSDPMAVVDPETMNVHGFENLKVVDASLMPSVVSGNLNAPVIMMAEKAADIIAGKGPLPAEQPPLWSPSGLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR18</accession>
    <name>A0A914GR18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GR18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10511.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10511.t1"/>
        <property type="gene ID" value="Gr19_v10_g10511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10511.t1"/>
        </source>
    </evidence>
    <sequence length="714" mass="78271" checksum="883972C57AD83E56" modified="2023-02-22" version="1">MKKKEGQHQNGTDGRKADADGQDLSDGKQQRSLASTSGTIKKRKKDAPDEFEQTIERKQKSVPNGQVANLTPKLQKNKTKPVVTVAHQAINGINPLDTILNEIEAFDTANKKKIKKETEMDNDEVDNAPCSSRQLPPTPMPGSYRSLNRMELARQDQDQSMVQSFLDRDDLMQRILAYKMLRGRVESYSTIRIKIDLDNCTIPEYELCPTEFDKNSSSDGKVAFVVKDEPADMQLKLINPETPDQGGMKRGPMTPPGSPGTNRSSSSGAEAKPTETILPVECCSTMPKVKKEFEDIAAPFDDSATKEMLRSFCTISGISKEMIRTFLGDDLQKLDKLKMEDLMKTFLESLKQVAGKKDKECSSKGIRSPVPSVVLPKDESKSIGSGGLSKAQADQQAEDNFEADAMEISSQATCFSGSFSFSNGLLPPPPAPPPILDGTETDFMVPPPPPPPPMLENTASSFPCSSLNRLISSPPLHSKVQSASDANQQASLQSHAYVSPFKKFSKRLSEISENGKEVQYRRSCWKSSSKNDANTINNESPTAETPQIELNKVQTNVPKTKVNSKRGQLPSSREVPVVVDLEFIKNTPPPPIPDIIKRRISNDNKAAGMMSSAVPMVSHATKRPPQSLLHMDLTRPPVFSRLHLPPPTFRQPNIVVHPSPPPVITTPNASTVLQTVVQAIGGNLRPPLVQAQKAPILPRPPLPNPASSPYGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR39</accession>
    <name>A0A914GR39_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914GR39"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10526.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10526.t1"/>
        <property type="gene ID" value="Gr19_v10_g10526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10526.t1"/>
        </source>
    </evidence>
    <sequence length="437" mass="50030" checksum="B8F67EBD176CA920" modified="2023-02-22" version="1">MKGHWRPANSKHAETEQVAGRDGGNFTCILLLSSRINKEPFDRILFHLKFVNFAALCPLCVVLRQLGVIGFYPKRLLLLMRHRHGAEKLLEIWFESDQQLGNGSKCTLRAIPESELRRLLNMAGCHILQVLRTDEIDAYLLSESSMFISDRRLILKTCGQTRPLMDTVTNVYYSRKNFFRPQLQPQLHATFDEEIDYLDGFFQGGSAFCMGPLKHDRWYLYTLNAPRAPLNFSDHTLELQMTGIPVELLRIYSKEACPDGAAECTWRSGILSLLPKGTVIQDELFEPVGYSMNGIPARDEYVTIHVTPESEFCYASFETNHRLGCLYEQTMKVLDCFRPGRFILTLFANEHSNGAIKVQQRLWFEVFPGYRRLSVQMLRLQCDTLLFALYHRDEKNEQKLKVGMDMGVVSECNESANGAENTGLAFRCFSLAPKNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRN9</accession>
    <name>A0A914GRN9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="Gr19_v10_g1077.t1"/>
        <property type="gene ID" value="Gr19_v10_g1077"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:microtubule cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase SIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF74">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="63"/>
            <end position="314"/>
        </location>
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        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="536"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="669"/>
            <end position="703"/>
        </location>
    </feature>
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        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="885"/>
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        </location>
    </feature>
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        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1045"/>
            <end position="1082"/>
        </location>
    </feature>
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        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
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            <end position="897"/>
        </location>
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            <end position="951"/>
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        </location>
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    <sequence length="1082" mass="118604" checksum="62C7A4EA5FB9EE94" modified="2023-02-22" version="1">MVQNQQQQQSQAVSEVKDQQKQSAYAAAQVQHVQQLNNNVNEKTPPTTATTTPSCTTVKVGFYEVDRTIGKGNYAVVKLARHRITKTEVAIKIVDKRRLDSVNLAKIYREIDVLKKLRHPNIVRLYQVMETNNMLYLVTEYAPNGEIYDLISKQKKLGEENARRKFWQIISAVDYLHSLNIVHRDLKAENLLLDAKFQIKLADFGFSNFFSYDGTLDTFCGSPPYAAPEVFEGKRYAGPEIDIWSLGVILYVMVCGVLPFEGVNLQLLRDRVLSGRIRIPYFMSSDCENLVRRMLTVESRRRPTIEQIKRHRWMHYDEHVHKYELSEQVRHAASEQQRQQLTEPHPQILRLMNNIGIESDKIKNALQTDAYDNLHAIYLLLLERLKSHPLSRSHSSSQTNQLVNSPSATSMPSPTTLRAQAVLASPTTKVAPAVVLTESSGGDNIEGYRPISRGATQIRRQSDGIAIVGGAVPCQCYCCSTARAHPMLRAMQPPHANLGIMTRFAQHQQTRRDSDGIALQFSYQMQQHKQQQQEELAAQGEENVQQQLQNGTTPTTAGQHCNANQHGTTVGWHHHSTTSDYESENCFSGSSAAGSTLSRQSTIGTISSFDDLIPDDGCPSCSHSAGGGSGGPLLFGGGGGGGGSALPPLHHPISATFCVDQLPPFDSQLSQDPLFSSQSSNKSATAFRPLSGSRSSSSNNGENASGCCYGATSGIVGAAGGSSNLLVRNVQLHPQPFLNHYTNIHHRLHPHLLQPSQNAAAFLQQQQQPASVRAPATATEAVDETEGDGAVQGQQQQNNICPQQQQQQLLMMCENGWRASDNAIGDPSVSFPTGQLGKRNRAVHEIHRPSGACAPLLHSQLRKMRISTGLASVAKAVPLAVGVTVPPNSTSPNSPGPTEKRSGGVGTALGMPKRISLPENLEFQPQMLLNLKQSIHVEKQLTSNSDTSDSASEMGGGPYEKPVLKASRLQHYQQQQQQKRKAARLQLLRQQSYQLAQKQSVLSFAQLSSSNASGGTVTIPAQLPQAFHQQQGVQQMQASTIEPQTMEEVDPEVEVVSPTSSGDRVPLSPIEDMKVEEVMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS23</accession>
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        <name type="scientific">Globodera rostochiensis</name>
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    <sequence length="119" mass="13037" checksum="B3CEE3413429D2E0" modified="2023-02-22" version="1">MDVLSALSSLYLVARLSLGEGRRLWRCEGFGSALAVPQGVQCPRPARVAKLDGRRIVDTDQNHCRRFILSPDCPLERDVACGDAKGSAPRLPCRRACSARARRESPNWTAAASSTLIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSB1</accession>
    <name>A0A914GSB1_GLORO</name>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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            <begin position="190"/>
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        </location>
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        </source>
    </evidence>
    <sequence length="235" mass="26187" checksum="59A0FCDF7E10FBDB" modified="2023-02-22" version="1">MRTVALMELYNNEQQVLRDWGPQTGPRVIAAIRAYAVNRGIQWPRQDGPRLSTPRSIPFDEAGKCRACKATEVELDTMITKEGVTIWCSRIKNAQFVPFDVVYDLPGHCFFRIKNKARVFNVPFGEPNPVNCVSQETQTEQQDLKRKAKVALDLVESGLMAGATQDGSRWKKAKTAINVLGNLLLADALPSSSPSLPPPPPIEQEVPPAKQQQADEEEEKLQEFYDSLAATTTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSD3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
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            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSD3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10316.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10316.t1"/>
        <property type="gene ID" value="Gr19_v10_g10316"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10316.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18006" checksum="6FA3C1181E372375" modified="2023-02-22" version="1">MVLRFGFYNHEYPYQREAGGASALQFTGSAPGCESDEAVARRLARELVWATRRRGHLSERRFIAEVARDCVMKKKGGGGDQEACLESPPARKALLDRQTITRAEGIRLIGPPTAERPIMERIRTLFAANRCKATDPKKTGIRPTTRPDTRSPRIFCRTACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSF5</accession>
    <name>A0A914GSF5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-pyruvoyltetrahydropterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914GSF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10335.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10335.t1"/>
        <property type="gene ID" value="Gr19_v10_g10335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.10:FF:000003">
        <property type="entry name" value="6-pyruvoyl tetrahydrobiopterin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022470">
        <property type="entry name" value="PTPS_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00987">
        <property type="entry name" value="PTPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10335.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41745" checksum="279294D1C4BBB8BE" modified="2023-02-22" version="1">MEMRSVSKAPTQDDKVSWWYWFEKLDGNRAKCRNCDWLRDRGPAKSTSILRCHLKSKHSELYDERMQAQAVTPNPEQRGRKRTMVVATEEHSCNDLTINADDNDLNDESDGPFRNNNFDKSPPKLATSFVATTAAADHSNEREIPNQKSLLDDMVANGALNQNLGLTMLSVFMNTLGGENGTNSNRTNDDEIGKFAIKKRRSKNTANLGLANNAAATSTSQNNLPIFAPTNAQPIVKICRVESFSAAHRLHNDNLPDYLNREIFGKCNNGNGHGHNYTWKVLLKGPVDAHTGMVYNLADLKREMNEVLELVDHKHLDMDVPYFRDNGIVSTTENLAVFLYNELSAKMASPGLLHKVTVCETDKNCFSFSGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSU0</accession>
    <name>A0A914GSU0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSU0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10067.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10067.t1"/>
        <property type="gene ID" value="Gr19_v10_g10067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10067.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12536" checksum="C6D0137044DDB12E" modified="2023-02-22" version="1">MICCWAQLSTRLSRQLLQRSLASQNESFGRSEVQFLCCRLPEEKSVEKEVELKTKQLQLAEFDIQYKRRSVELVELQIVELQRKMGRYEVEAEGENTFTVLKKSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVN3</accession>
    <name>A0A914GVN3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GVN3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11202.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11202.t2"/>
        <property type="gene ID" value="Gr19_v10_g11202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000065">
        <property type="entry name" value="Si:ch211-141o9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="8">
        <location>
            <begin position="79"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11202.t2"/>
        </source>
    </evidence>
    <sequence length="329" mass="37401" checksum="9D61D52640064603" modified="2023-02-22" version="1">MKSFIISELEEEEPVKPTSTSSALTKREVKAKVELGVTSKIVYMSNTATSVIRAGLYSEKNLGVHVSAAGSLENAIWNAIEIGCRSFALFIRNQRRWEAKPMDESVVDRWNKAIKETKFPLHQIVPHGSYLLNAGSPDDKKLEMTRKAMLDECRRCERLGIQFYNFHPGSTTGKCTRERSIKTIAETISYVQENTDFITLVVETMAGSGNTIGGAFTELRWCYDIVNNYEEVMEEFDSMIGFDFLKAVHLNDSKEGCSSKVDRHENIGKGNLGTKAFERIMKDDRFNGIPMLLETPEGKYPQEMKLLYELEEKELPKKRRMQRADESVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW58</accession>
    <name>A0A914GW58_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW58"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11321.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11321.t2"/>
        <property type="gene ID" value="Gr19_v10_g11321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11321.t2"/>
        </source>
    </evidence>
    <sequence length="268" mass="31021" checksum="0DA70149D1B28044" modified="2023-02-22" version="1">MKFKICGKLVDLQPNFMNAAKENCTPKSVSRKVKKFLFWKCDQLDFCFIVYEGRFQVLYLVSKYEITALSYNITKTVEMGQKESRNAVVNWALIKREELDDKIQELNKKCANCFEESSLNMLFVMKSSDEKGLLWQRSARIHCFTVLDEKIYRKTYNLYQFLKFYESFIQVLEASEASNDQKTSENGHNLLNLSIYNDSCCGCTEDGKCIICFDSRPDSVLPCAHAYCSQCIDAFHAVDQNCCPLCRYPLKRHGQDEAWETGSDSEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWE4</accession>
    <name>A0A914GWE4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWE4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11813.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11813.t2"/>
        <property type="gene ID" value="Gr19_v10_g11813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="141"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="351"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="570"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11813.t2"/>
        </source>
    </evidence>
    <sequence length="619" mass="69489" checksum="A333C7A11BDF8613" modified="2023-02-22" version="1">MPPVGVRGPYAKNGVKLPSNNNSNRQRRQKKIGHSPWMAQPGLCWRRRLLLVVTSLLLLIASACPSPEGRKAFFRRNSRQLRRLSRLYDWEVDERGAFRPVIPSSQQNRFSRSAVESNAPAAVPAEGQQQQQPYCANDSYILNRILDGYNRHKIPGGRVKVMVEVWVQEITTISDITSDFQLDIYISEMWNDQALDYSYLEPCKYNLSLNSILLEKLWTPNSCFINSKTADIHRSPFPNIFLLIYANGSVWTNYRLKLQGPCEMDLTRFPFDNVTCSLTFESFNYNTDEVEMDWTSVGVEKMREQIELADYLLIDIVPERNTVPYPAGYWHELTMRFRFSRRAGWYILQAYLPTYLTIFISWISFVLGTQAIPARTMLGVNSLLAMTFQFGNIIRNLPKVSYVKAIDIWLLSCMTFVFFSLLELAWVGYLSRKEADSREAAKAAQDAAAAVVERVTVPPPRYGSVDAGSAEGRHNMQLFRRRAGVVPLTNDTDESATLLDHPQRGGRMKQPPNNDYGYVPPGLLNGSARGGVAAVQMDNNVTSPPPFVKKVPSLADFGFDTFAITSPAAATADEDEQFEPPQGAATAPCGGWFGTGGTSTPLSSGRGRSQREQLALRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWH2</accession>
    <name>A0A914GWH2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWH2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1182.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1182.t1"/>
        <property type="gene ID" value="Gr19_v10_g1182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1182.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12465" checksum="ABA3E167901FF531" modified="2023-02-22" version="1">MVIHGLRDCLLEVLRDYALRIGLLEHSNSVASSDTFALFQRRLRLNPFVVGTNEATTELRCDICCDTLMNESPSTAGDVRLLYDGSAIHERCHHRSKCQSEEQQNGVTTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWP1</accession>
    <name>A0A914GWP1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWP1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11863.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11863.t1"/>
        <property type="gene ID" value="Gr19_v10_g11863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11863.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34288" checksum="B8FC14C684EBA2ED" modified="2023-02-22" version="1">MLSSVEDLKAIPCGSHLGSCTGQVVRLLPSDKKLTVLLICTGGELFPVTIFKNLTNQNALVKACILGNVLKIAPVKAQRFSDKFDGKIFFNTPLDYEFVVKANSKFEVLPAEVQSAQNFEELSSGGVYQISCIIASSFVQIDNMFACVVGDLQNKRADLYVHGVSILEKIGALKQNDQVKLARCYSRIDDECLTIYASVDNLAPMNRSFVLEKVLETPVKRKCQDHGDEPAYGQIFIVDTAQAMNALKQANAGVDFQLLRTVLENKSIEDKGIMYQEPMKWQLFMYLEQTVKYQMLKLWFENAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXM6</accession>
    <name>A0A914GXM6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12137.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12137.t2"/>
        <property type="gene ID" value="Gr19_v10_g12137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 23" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037609589" description="receptor protein-tyrosine kinase" evidence="23">
        <location>
            <begin position="23"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="25">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="1045"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1372"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1081"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12137.t2"/>
        </source>
    </evidence>
    <sequence length="1401" mass="159356" checksum="87E5D3FA750B45EE" modified="2023-02-22" version="1">MLFNTLSLLFCLPIFLHSLIEAMENETRCGTIDIRNHPKSAFQPRYQTDRWLKYKECTILEGDFTISMITQPNITDNDFPVFEKLREITGSILVFQIRGLKSLGRMFPNLRVIGGHSLIMNYALVIYQNSDLMDIGLTKLTAIKNGGIRITENPRLCFAHDIDWNSILVGTIKDRIIDEVAICKNECPGMEDQSHCSVSSETGRMACWNSTQCQKICLHSAKTDAGCTERDELCHGECIGGCTKSNDNGACNSCRNLELNGKCVPKCSSDLYEQFGRKCLTKAECIGLPAVPSSGGNDEKAEWKAFHRQCSYECPTGFQEDPLNPHSCVKCLGYCPKKCPGDTVDSISAAMKFSKCNLIEGNLEIEMRIGVELVTADKFTEAFGEIEEITGYLVIRFSTPFMSFHMFRKLRRIHGQQLYKNTYALVVFENQNLHELFNIEKQNIEILRGKVQFLNNRMLCYKKIVTLIEHLGFNVTDQSVMDDISPVSNGDKAICDEIPLEVKIVSVYSYGFVVSWIPFNTTDLDHRKFLGYQIFYKKVEKEDPEMNINDDRSACSDSWMMLFVTDESEYGYGHAFGDESNANVQNAAKGELLNQGVEANTLYGVYVQTKLVNHPGARNAISKILFVKTLFAPPDPPRMKISEALSSSSIKLNWDPPLEPFGDITHYMISWNLVIDYDTAKATVVCDKRALLSNMPVKVSPSFASQDTCSKEGCCKCTAESRASEGNVRGKSIDANKLHDERKEKSNFEDQLQNVVFVQKTINSDGPHVVRIRRAIGFNETQRTVSTGPFLSYYNKTELNVTAFNSNILNYTMGKVNVTGTTFVLSGLPHFSEYHITVHACQNISVPDNYCSNRPAWTSARTLPIPEYDVVDPDTIVVLNSTEEKPNERRIYWKPPRTPNGFILAYWAKLTRDEESLPVDRCVPYEEFEKNETGVVFPGLSDGRYTLEIRVESSSLIYNKHVTIKEGIFVIYTPGFFTLKSIAIIAAVSLLVLLVTGVFLYHFANRMFGKKVEEYWRQTISANPEYLSQMELYKADEWELKRDDIALEEEIGRGTFGKVFRGYGRSVHSLNGETFGDCAVKTVPETASNAERLHFLIEASVMKQFSTSFIVKLYGVVSDGQPVLVVMELMAKGNLRDFLRSHRPSSEENKENRPLPTAEQFCHRDLAARNCMVHANESVKIGDFGMARDIYYQEYYKPSGKRLMPVRWMAPESLKDGKFTLKSDVWSYGIVLYEMLTLGQQPYAGLGNDQVFNYTGVQRHVLNRPTGCPDFWYGLMLFCWKYDPRERPAFRQIVRYLNHFNFIAEEFKQISFVLNDKPNDMEEFYHFDINLEDEIMQRNVMNEEFVYGMDEELDDEDMADFVSEDGLQHKPICVNNRRSDDKDEDAEEVMKSASDAELSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYC0</accession>
    <name>A0A914GYC0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NIF system FeS cluster assembly NifU N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYC0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12461.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12461.t1"/>
        <property type="gene ID" value="Gr19_v10_g12461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000001">
        <property type="entry name" value="Iron-sulfur cluster assembly scaffold protein IscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12461.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16181" checksum="1013B27AE559C43A" modified="2023-02-22" version="1">MMRPLVLRSAAVRLQQIAGYHEKVIDHYENPRNVGSLDKNDPSVGTGVVGAPACGDVMKLQIKVDANGKIIDAKFKTFGCGSAIASSSLATEWIKGKNLDYASKVKNQQIAKELSLPPVKLHCSMLAQDAIQAALSDYQKKQEARIEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYR3</accession>
    <name>A0A914GYR3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYR3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12023.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12023.t2"/>
        <property type="gene ID" value="Gr19_v10_g12023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18287">
        <property type="entry name" value="BTB_POZ_BTBD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000051">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12023.t2"/>
        </source>
    </evidence>
    <sequence length="690" mass="77820" checksum="C09502FF1CE4699C" modified="2023-02-22" version="1">MSTHYYPALRNCGSCASLAGSLQEFNSSSSLNNRTSSFSPYGEIQNTAQLVEQIAFLYLNEEFSDLVLIVDGQRFPVHRVILATRSSYFKAMLYGGMRESSEKEVTLFDTPVQAFQAVLKYIYTGKLQLKSLELSLVLDMLALVHKYGFSELEAAIPEYLKSILKARNSWRSPAWISSTITPQTFCPDNLFFNYPPQHSSEYSAETLFVRPNWKYFLPSAIGLMHTPKSPLASLRCFHNADQILDAIKEQNTKRSSELNYRGFLFPGTNVATPLLGAKVTGGDFRSALLSNKTSEDETSAADPIDRTYAKHLINQTNSGITIELGRPFILNNIRLHLMDRDQRTYSYFIEVSVDQVDWVRVIDHSHYVCRSRQNLLFDERVVKFIRVIGTHCSVNNTFQLSRFEAMYVTDSCAIDNSTTLQIPRLNIATIANNAIVVEGVSRSRNALLNGDTKNYDWDDGYTCHQLGSGALVVQLPQPFLVETMRLLLWDCDDRWYSFYIEVSTDQCKWAKVAEVNECRSWQTVHFLRQPVVFIRIVGTHNSANEVFHCVHFECPAMETDSASEEERVARLRRIIAHTVDEDALSATVQTSSNGIVPVEKFEFLESCQNALGAIVESIAAGVGEEVGSQEEGEERQAEGRPNHSLFGDIDQQEGSSSGRAESESSHSETVYEENRDRESMPPMESHETSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ39</accession>
    <name>A0A914GZ39_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Signal transducer and activator of transcription</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZ39"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1173.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1173.t2"/>
        <property type="gene ID" value="Gr19_v10_g1173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09919">
        <property type="entry name" value="SH2_STAT_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000493">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47655">
        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="STAT transcription factor all-alpha" evidence="13">
        <location>
            <begin position="183"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="STAT transcription factor DNA-binding" evidence="14">
        <location>
            <begin position="372"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Signal transducer and activator of transcription linker" evidence="15">
        <location>
            <begin position="540"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1173.t2"/>
        </source>
    </evidence>
    <sequence length="850" mass="96295" checksum="96890F92655C3E25" modified="2023-02-22" version="1">MIGRLRKLGIIGRWQLAMRKLLLFRQRLPPFGLWPRLLRAAAVSTPLVGDDYSSPIIPGAFIRRPLWQQQLSGRVPIELGCCCSKQVISLAAISFSSPTVAAGDNPARERRKEKEKKEILVYRQSQYRSGSPISIRQMQQLNPVGGCASVPTPAAFCSGASPSSSVPPSANSTEQQRTVLMTLTKDCQTLWEQNKDMQGRFVNDLTELQRLQLAISQLEAEQRHDQLKQTRHQMMEMQRRASQLYEQLTDRRANLVQRLNDGVQLIVLMQSQLISERLLDWKNCQKLSQIGVVFEQREQILDEIQSEFEVLAENNWTLRACACWQLDLLKRSPRLSDSQSVQSHISNLTYILETLTKLLCMLVTQSFVVAVQPDPVLKTQHKFVAEVRLLIGERLGIKQQLINTNVTVKIIAEEEAKMLSTGQLNEKDIKTVGSISNDFEKLVLDERGHMAAKFNNSKLSRIAHRKPPAKGSLQASQCAQTATDQKYALLFHITPFQLGNLGKFDVWTLSLPIMDCDAQAVILWQRAFSSVNRTNASDDVSMVAWPDLSRVLRHKFFLFTGANRPLSESDLAYLGDKLGMHSHGDNKPITFQRFAKQNLRDDVNFSFWEWFFLIMQLIKQKLLKFWDEGWLVGFISKQDTSSQMMMCPNLTFLLRFSDTQTGAVSIGFVCEEDGMKVPFHLAPFTIKDLDQLSLASRIRNCPQLQEIRYLHPDIEKEEMLAFFESEEQRLRANETSPTGYIGSEIVMVAKTAGCKLNSALGSDSPSPMSNQWSPGELQQSNSMEISDDIVSMLNQNQLEAANVESLLGFQVGHRMAVDQQQQPMPLDLSFMDSFSVQPNAVFLMGQQRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ62</accession>
    <name>A0A914GZ62_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12137.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12137.t1"/>
        <property type="gene ID" value="Gr19_v10_g12137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 23" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037885795" description="receptor protein-tyrosine kinase" evidence="23">
        <location>
            <begin position="23"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1031"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="25">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="1094"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1421"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12137.t1"/>
        </source>
    </evidence>
    <sequence length="1450" mass="165145" checksum="BFBE1E9E57CF4F95" modified="2023-02-22" version="1">MLFNTLSLLFCLPIFLHSLIEAMENETRCGTIDIRNHPKSAFQPRYQTDRWLKYKECTILEGDFTISMITQPNITDNDFPVFEKLREITGSILVFQIRGLKSLGRMFPNLRVIGGHSLIMNYALVIYQNSDLMDIGLTKLTAIKNGGIRITENPRLCFAHDIDWNSILVGTIKDRIIDEVAICKNECPGMEDQSHCSVSSETGRMACWNSTQCQKICLHSAKTDAGCTERDELCHGECIGGCTKSNDNGACNSCRNLELNGKCVPKCSSDLYEQFGRKCLTKAECIGLPAVPSSGGNDEKAEWKAFHRQCSYECPTGFQEDPLNPHSCVKCLGYCPKKCPGDTVDSISAAMKFSKCNLIEGNLEIEMRIGVELVTADKFTEAFGEIEEITGYLVIRFSTPFMSFHMFRKLRRIHGQQLYKNTYALVVFENQNLHELFNIEKQNIEILRGKVQFLNNRMLCYKKIVTLIEHLGFNVTDQSVMDDISPVSNGDKAICDEIPLEVKIVSVYSYGFVVSWIPFNTTDLDHRKFLGYQIFYKKVEKEDPEMNINDDRSACSDSWMMLFVTDESEYGYGHAFGDESNANVQNAAKGELLNQGVEANTLYGVYVQTKLVNHPGARNAISKILFVKTLFAPPDPPRMKISEALSSSSIKLNWDPPLEPFGDITHYMISWNLVIDYDTAKATVVCDKRALLSNMPVKVSPSFASQDTCSKEGCCKCTAESRASEGNVRGKSIDANKLHDERKEKSNFEDQLQNVVFVQNCEINYDPNHCADPAVDALEHTKQKTTDVQQQLQDLQLVQLRRKRQQFKKTINSDGPHVVRIRRAIGFNETQRTVSTGPFLSYYNKTELNVTAFNSNILNYTMGKVNVTGTTFVLSGLPHFSEYHITVHACQNISVPDNYCSNRPAWTSARTLPIPEYDVVDPDTIVVLNSTEEKPNERRIYWKPPRTPNGFILAYWAKLTRDEESLPVDRCVPYEEFEKNETGVVFPGLSDGRYTLEIRVESSSLIYNKHVTIKEGIFVIYTPGFFTLKSIAIIAAVSLLVLLVTGVFLYHFANRMFGKKVEEYWRQTISANPEYLSQMELYKADEWELKRDDIALEEEIGRGTFGKVFRGYGRSVHSLNGETFGDCAVKTVPETASNAERLHFLIEASVMKQFSTSFIVKLYGVVSDGQPVLVVMELMAKGNLRDFLRSHRPSSEENKENRPLPTAEQFCHRDLAARNCMVHANESVKIGDFGMARDIYYQEYYKPSGKRLMPVRWMAPESLKDGKFTLKSDVWSYGIVLYEMLTLGQQPYAGLGNDQVFNYTGVQRHVLNRPTGCPDFWYGLMLFCWKYDPRERPAFRQIVRYLNHFNFIAEEFKQISFVLNDKPNDMEEFYHFDINLEDEIMQRNVMNEEFVYGMDEELDDEDMADFVSEDGLQHKPICVNNRRSDDKDEDAEEVMKSASDAELSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZK8</accession>
    <name>A0A914GZK8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZK8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12266.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12266.t1"/>
        <property type="gene ID" value="Gr19_v10_g12266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12266.t1"/>
        </source>
    </evidence>
    <sequence length="348" mass="36873" checksum="9397B878D2E57994" modified="2023-02-22" version="1">MQLVQLLAAAAAHSCTILCPPPFSKPRVLLQLVRSVMQLVQMLLAAAAAAHSCTILCPPPFSKPRVLLQLVRSVMQLVQNAAGSCCCCSFMHNPVPPALLQTPGTSSTCSFCYATRSKCCWQLLLLLIHAQSCAPRPSPNPGYFFNLFVLLCNSSKMLLAAAAAAHSCTILCPPPFSKPRVLLQLVRSVMQLVQNAAGSCCCCCSFMHNPVPPALLQTPGTSSTCSFCYATRPNAAGSCCCCSFMHNPVPPALLQTPGTSSTCSFCYATRPNAAGSCCCCSFMHNPVPPALLQTPGTSSTCSFCYATRPNAAGSCCCCSFMHNPVPPPNPNSGYLFNLLPGPTQRFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H026</accession>
    <name>A0A914H026_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H026"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12696.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12696.t1"/>
        <property type="gene ID" value="Gr19_v10_g12696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12696.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12142" checksum="14E35D8C85E8675E" modified="2023-02-22" version="1">MEGMEALKVEFFKSADPVNFIMYFWTTFAIILFDEKNNLTGERLVLRQIKTFEWLLVRCPIERDEAKWAELEKEAAEWNCIGINFKDNEIGDGMSDGNEAPENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1K3</accession>
    <name>A0A914H1K3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1K3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13297.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13297.t1"/>
        <property type="gene ID" value="Gr19_v10_g13297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13297.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="56917" checksum="9C2DBEB99D74ACDE" modified="2023-02-22" version="1">MIHLSIGTYHTFGNMLPYMASYMRNFTDPTIKIEHLIWVPTFQGCFPLAMVIGGFLSKKMGPRLAATIGCFTMCFGVFLSSWTIQHSYYGFLFTYGLMFGLGQGIAYVIAVSCVINWAPQMVGLGSGIVAAGFGISSSIFAPIQTRIVNPTNVAANKDGYFNDQHLLMRVPGLFNTLAIVYFFMQCIGLVFICDPPEEFARRFLAQDTTSLIDMAWLSKKRSHWLAANRSPLLSSGWASAKMGLQRVERFGRYQYSRLATAADQQDNSDDDQGHKKDSLPDNEQLTNSFPTPPNESDEAADDDELEIGKQGPPVSLNTRQMLQSSTFYFLFISLFCCSFYGNFFYNLYKTFGETFIEDDFFLAIAFSLGSVANAIARVGWGLLTDRTSFQTSLCMATSLATVLLLTMPMTALSGRYVFLLWLVLMFVCLAATHALFITAIVRCFGSVHKIFNYGCLIVSTSLSGVMLAIGSEFLLQSIGYNWAFICTAAFPFVAFLLTSAIRITPHGHLIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1U1</accession>
    <name>A0A914H1U1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1U1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12452.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12452.t1"/>
        <property type="gene ID" value="Gr19_v10_g12452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12452.t1"/>
        </source>
    </evidence>
    <sequence length="514" mass="56387" checksum="DCF33106668506B0" modified="2023-02-22" version="1">MADRQTQYKNIGKDVEALRKNRTEQVVSIRKEKRDDIMSKRRNIPAEDAEDASTSNAGGVALVYDRSNLQEIVVQAQSTDPEVQMLAVTQARKLLSSDRNPPIDDLISSGILPILVNCLESANATLQFEAAWALTNIASGTSDQTRAVVQAGAVPHFLKLLESPNMNVCEQAVWALGNIIGDGPHFRDYCIELGIVQPLLKFVAPDIPLNFLRNVTWVMVNLCRSKDPPPNRQIVQMLLPMLAVLIHHQDTSILVDTVWALSYLTDGGNDQIQLVIDSAVVQYLVPLLGHPEVKVQTAALRAVGNIVTGTDEQTQLVLDCGALQMMPALLSHQKEKINKEAVWFLSNITAGNENQVQSVIDAGLVPMIIHLLDKGDFQTQKEAAWAVSNVTISGRAEHVQYMVVLDGLNNILKKSGPHTDEVCQKIEECGGLDKIEHLQNHESEEIYKMAYEIIDNFFSSEEDDELVAAGAAAGQHQHPDAAGDAAGAPIDAAQPQFMFQPSQQNVPDEGFSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2G5</accession>
    <name>A0A914H2G5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2G5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13386.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13386.t1"/>
        <property type="gene ID" value="Gr19_v10_g13386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47836:SF1">
        <property type="entry name" value="GLYCO_HYDRO_19_CAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47836">
        <property type="entry name" value="PROTEIN CBG09520-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036974417" evidence="1">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13386.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11070" checksum="D9C44FDF1237F2BF" modified="2023-02-22" version="1">MLLLQKCLLFPLLLLFSVLINSSRRSPVQNCPKTRRYGRIQSQKCTGAVDPNLKPRVRLEKWFTRDICENLFPIANQGWGEHPCMPYSFDVFTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2K3</accession>
    <name>A0A914H2K3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2K3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12653.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12653.t1"/>
        <property type="gene ID" value="Gr19_v10_g12653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12653.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40486" checksum="74623D3FAA969183" modified="2023-02-22" version="1">MSDNPKKVEKRLKELFVCDDVLFEVFKFCGHFVLGLKVALISDRFDFLVDAHFKSMEWSLGELYICRAVEGTGAGIVKYVGNKVERQLPIPQKPLPDNVIGFECLRICYIDRSVIEFLQSIRRLFDSKMTILCIGTPYFQNRSWEIIWHRIWPLIKDKICGFDLDSSDLDYLRRFSPTVLSDCAKLRLIKSVYLFPAFPADDSASASSAKALTKWLHTPCGDGLPKVAECRYCLEALEEFVNSINPVNFIICLWNRASEIIVPFELKNNLTGERLEFRHFEKDKWLLVRCPLERDAVKRADCASKCNWIHINFIINFEDGDIGDGILDANEGPSEPKKRRNLDKTIQNEGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H509</accession>
    <name>A0A914H509_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13888.t3">
        <property type="protein sequence ID" value="Gr19_v10_g13888.t3"/>
        <property type="gene ID" value="Gr19_v10_g13888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036812141" evidence="11">
        <location>
            <begin position="22"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="202"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="571"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="670"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="703"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="736"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="769"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="802"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="14">
        <location>
            <begin position="874"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="13">
        <location>
            <begin position="1519"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="958"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13888.t3"/>
        </source>
    </evidence>
    <sequence length="1614" mass="178638" checksum="021C45627243876E" modified="2023-02-22" version="1">MWVWVVVVLLELLLLPLRMRCAIYGQKVPAREGSGTALFGGIGTAPVACGEDRLAAGLAAAAGSICIFTYARHRRRRCFCGFCGFCCCTSSIDARCEHWSSSARLGGVRFKHFGLLLDTHQTAPCPLSHNNQLICSAGNRTSTSALGYQPNYSHYYYHKKLDIARQNSDQRAPSPLRHRSDAFGWPPFKRSLASPPEGFKHYAIEEEIGSGQFAVVRRVRHIASSALYAAKFIKKFRGQHCRRGVLKAHIEREVDILRSVSGHDGVIELVELFENASEVVLVLEYVSGGELFEHVCQHEYLTESEAAQFLFQILRAVQHLHRLHIAHLDLKPENIILREQGEHFVKLIDFGLSRKLLPGSCVREMIGTPEFVAPEIINFEPLQLATDIWALGVVTFILLSGSSPFLGKTRDQTFANITAVNYQYPHGHPISELAKDFIARLLVRDVKRRATVDECLRHEWIRRHVQPQQQNIFHHPMIILSKQKQNGHHLVHICSSNSRAIRSRWKKFYAAVTWCLAYLQGIDGREASVHFKRDNSISSAIFIACERGALAQLKQLVHGCRIQLDNVFNELGESPLHVACGNGFQELVAFLIELGADPALEDGRGDTALIWAARNGHAHLFNTFILSPVLINATNSIGETALHLATRYAQGQAVLSLLERGADPQLQDKHGETPLHIAAWDGQSGLLDLLCRFCVELNFTNLEGDSALHVAASRGHLECVESLVENGANLDEPNQNGQVALHLALSRGHVEIALLLLSRGCKPNVQDRVGDTPLHIAAERGLSAAAQTLCQLGIPVDVQNAKGFSALHLAARHGHIDIVRCLCLSGASVHLKSNDGMTAEIMALAQEQKQIATLLAKVRPEKARIKLVKQLSTMEGPLRRIKLKVFGHPGAGKTRLVQALQRSSASSLNSLMESVSRRFSDNLFPANSVVVNSSSADPIPPPLSAAINGGSATIIMASPSKSGENADSSADEGIHSGVPSSSSTTSSSSTNGIGHRHKTWPCAERGSAGRGPTQGIDIQNVAFPECGEFSVWDFSGHEPFHICYDHFVGNTDCVHLVVTRCSDDPTDEYKELLYWLNFLKGRVTPSEPIGHCGQIARRSVVAIAGTFMGGDCPITRNEAEAMMRTLKMRFETHFDIHGQLFLVDLSAQVDCAGSRELRTFLARQRDAILMRLQRPLRMLDETMAFMDQLREQYAQFPCITWPYFTTLIRSEVNPLASDGHCRQLIQQLQLIGEVVYLRDEGSEIDFIVLSPDWLGTHLLGTLFSPRFAHSPRASGRFSLEDFGAVFPEVTDPADMLQILETLQLCCVADTDFEFTVFISAAAPQDVWLPNRPRFVYGGLRIKPARGMEQTMQSIFPRIQVALRRSMQDFQDPIEADLAQWRYCSKMLSGKMEALIRLVGEAVEIQIRGPPEMATSCIYYLEDLANLVEQTGAEVAPGVSTERHFLSPAHLREHKTSPAMFTPETIMEMQQNESLIIVNSEGEEEEFTDVVCFGSKEAAGLLTLGVDISVSQLQLSARSELAALLDAPNTLGMDWSIMAVKLNLTEQIPEVDSSGQSLSRTDQLLTEWALHSPDSASVGKLASILQEMGRNDVKELLFRRVPLYLFSPVEQPNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6T7</accession>
    <name>A0A914H6T7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6T7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14355.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14355.t1"/>
        <property type="gene ID" value="Gr19_v10_g14355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037892884" evidence="2">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14355.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20720" checksum="EE57813F270E601D" modified="2023-02-22" version="1">MPTFLFLAAICLLVAASILLETDAVGPSSSGNAEPKAGNTAHKANASDVFEAMFRFDEANAKAAAVGTAFSEEIMPVEVPDVEVDAFKAMMKRHSWLYKQRHQLKDLMENRPQKKPTVNAKLETEGISNSSPKYRQRTGKSIAASVKSATSSGEDEYSSATETGGTNANFASTSLSKSTKLPSLQKLIISLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H715</accession>
    <name>A0A914H715_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H715"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g146.t1">
        <property type="protein sequence ID" value="Gr19_v10_g146.t1"/>
        <property type="gene ID" value="Gr19_v10_g146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g146.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33973" checksum="3E91E9C9ECBECA9B" modified="2023-02-22" version="1">MKFLFLLGHNNGILNSFIQSSMLPHSTSILFVCRNRLAIRSAAAHVRQMRNSSSLIKDGVAESLKLMTASNLLGPTTAVLLNLVHKQVYEKMGAHYGISASIDEKDGKWTLNTQDQLILRSANELATENLRKHVEQKNLWFARLLALRVCLVPVWVHGNMGLMRYVQDIGAQCLPGFFWLSSLTQADPYMVLPLCMGCLALLNTWVSRWMFMAGSQNYRVTAACLDIVMVAIVIAGTKIMIDLPAILPLYWCFTLSSSLLQVLLLQHPRVKRLLGIGPLPTDTPTPFRSLFRRRRFIPSSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7I9</accession>
    <name>A0A914H7I9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7I9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14437.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14437.t1"/>
        <property type="gene ID" value="Gr19_v10_g14437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14437.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39144" checksum="F3D0522FF3CD988A" modified="2023-02-22" version="1">MSVETKLGNDQKNYLNFVSFVTTFCLNDRFDFLVDAHFKLNEWSLGRLEIRCAADGNGAEIAEVVERRLPIPQEPLPAKVIGFERIMISYIDQSAIEFLQSIRRLFESNGTNLSIGTAASQNHSWQIIWHQIWPLVNENICGIYLRSSELGRLRQFSPTVLRNCPKLQLIHSDYIFPEFPAADDSARGASSKQAVAKWLHMPRGDGLPKMLRCNFYLHKIEELKMAFVNSTAPVNFIICLRSWSSKANDAPFKVQNNLTGERLVLRRFIDRSKGLLVRCPIERDEAKWAEWEKAALEWKWRQWNRIAIYFNDNDISYGMLDANEGPCKPKKRKLDVSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7N1</accession>
    <name>A0A914H7N1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 8 central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13972.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13972.t1"/>
        <property type="gene ID" value="Gr19_v10_g13972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="3">
        <location>
            <begin position="674"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1569"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13972.t1"/>
        </source>
    </evidence>
    <sequence length="1623" mass="178440" checksum="291B60D8103526DD" modified="2023-02-22" version="1">MSSSLADRHRRHQPAARVEPGAATTASSSSWSGSASAMMPSVLEPERRDEEKHRLNGGGGTSPPQLAETNTESTEAAEDWLLDELDQMSVRTQTLEEIMAEKNTDFEFPDNDDELLYLLNDGGGGGGAVSSAGGDGASGALPAGNGADTPSSLALTTAGPPIVPMGRYGATATELPNAYQLDSPLLIQRADAISHQIASVHERPPSGGRPTVLCVGRQLIAVGTARGLCLLFERGTQRLRRFIQAEKAFGSISCLDFSLDSQQQRICAGFSSGALTVFDCARGRVLFSGDDLIQPGRAVLHVKYISNFALLIVDSGGNVYEFHERQQQHQGKVKGRKRGGGGVRCLFAGCKGEVTNICFVHTDDVELLVLATFHQVLLLSTKRRGAPVGQLRLHGSPLHPPVIDWRERRIGMISGGHSANATAAASSLRVGGDLLFPLTGVVFTEQPLLNLKWLDNWALLAVIGEAGSEQLQLMELHHEQQKKGGQQRVLGASITASTDIGSTVQLLYNSADFKGLATGQYVSEAMSKLADSVCLHSVSRHDGDVDEQLHLLGRNGVFGVQLMDQAEQLQALVERHDFASALLYAVDVCNGRVRDRSRLGNFRAQASHEVPRLVTQLLDQTIDGLDSGRIDDLVVHYKRNIYVLIRACISTSHFELLYGTVYDQLQKDSLCRPIFLELLEEFVLERQLDRPPPGLVNDYLAYLLAEGQLPQFEQSVTRLPVECMDLHQVMTTCLHNQLFDGLCHVMNNAMRDYIGPLKEMCEHMHHSVRKEVLSDCDIAQGNKLLLYLSCCLAGRAYPYGELPDEHVAKTVPLETYKFLVQLRPKFVAGPPSSAGSTPSPTTSKEVDDVDADATLEDAANCIASGNNLIRGNAVIANRHRSAVAVAGGCVRRSAVADLRFPHLQLLLKLDPQQFLNVLNTCADAPVFANVEGRLKRLVDVLIAKCVEDEDERNELGPLLIAFVVGLLQKGSIPKDVFIFTQLIKRVLQRQFMNVRAQKQAELHIVDFLRVVPEIDMDIVLDVAQKQPHIHICAYIFTLRKQYVQLLECCLGDAVDPKNVFHILADLLTNLREPGQLLELREFVRAQLGRLSTLDPQLTAHLVMAHLPEILAEARSNPRKLPFQLVRHCFVLRRQQGHRTLSGDDEEQDELFFDYLFEDIIDEARALAESEKSDEATAALDNELSDLLRYWLPLGAVTDHCLNVAMQQQRPNDLLATISLLLVARGHIQRAFELIFLEGIERRDRQPPEERCIASLLELAAAHPAEAQHGDWLAKLFRHLLKALPEATSIDASTVIEQQLIRPKTHLSRVLTAIIEQQQHQHDDISESGKEKCSPASVIVAELFNHSLFRHAPLHAFHRLVRQMLLWCEIRVLMERATCACARHELAEQFGRNLLGLGTRPAFAVHPENAKSCCSTTTPYASLSSFSAQDCCRPIAGPATPAAGHCLWCQRRIVKSFYLFPCGHTLHLECVEEQHQKPSSSSPTVAETGAKTKRRHRCCPCSSSSAPLNWANNASTKLLKGEQHQHNNNSRGGGDEAVVDEESMASLPASCDGAASNKKLANKPTTTAALLTGAGNGRSSNNEMDERRAASAVLRRLEHEFPLCTGPPPPAKTANNAFHRFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8M9</accession>
    <name>A0A914H8M9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">7TM GPCR serpentine receptor class x (Srx) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H8M9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14820.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14820.t1"/>
        <property type="gene ID" value="Gr19_v10_g14820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14820.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22538" checksum="CE84E4FF56909DCF" modified="2023-02-22" version="1">MSLNSTLSEVYLELTNARPCWSLIIFASIYTILAIAGIFWNFSVIYVTIRTKSMNNSANKLLAIYSFFEIVHQSGHFLFAYLCNFAVNNCSLYAPPNSNSHQFNIRIFRALFVIISVNIGGYFLNFFDIIIIIIPMFGNDIMSIWKLNQIFGILLNISASSNAPILYFTSKEYRKAFDKERQTIIKLFNRNSVQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8X3</accession>
    <name>A0A914H8X3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8X3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14890.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14890.t1"/>
        <property type="gene ID" value="Gr19_v10_g14890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14890.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9602" checksum="243B24B46D533EFE" modified="2023-02-22" version="1">MKIRGITFDVDNHKTLHYEAFNEMVLSYGEKMDPAFFVYKNDFGPTRESKVVMREKHKMYMPICQKGIIDEDFNVLPFGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9E1</accession>
    <name>A0A914H9E1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9E1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14994.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14994.t1"/>
        <property type="gene ID" value="Gr19_v10_g14994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14994.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33107" checksum="7E075DA88CE47348" modified="2023-02-22" version="1">MQANIFSPIKTLITIDVQTSECLGQPLFHPNRIKMELIGTLCILFVILICLHQCSGLECKRGYRVITSEGAAEKGIRTEQCPSFEFQYCVATICTTVGERALSSIVWGCYLHNDEASCANYTTMSMIDKTKLKNIRCYCEFGEIGKDLANEQFLLPTDHIKCLSGVFNVKGYGSTVVKNCTKEAQYCYTASCESDNNSAAMLWGCRSQDESCTAIAAKEAAILKHSLRCQCVFGEEGVELSNENVTLPIPPVFIDIEATNMDSSSPDIRLIGEINRILLLLLGMVPFHAMFAYHIFGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBW9</accession>
    <name>A0A914HBW9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBW9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16092.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16092.t1"/>
        <property type="gene ID" value="Gr19_v10_g16092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16092.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27335" checksum="04227D6AEEC8AF57" modified="2023-02-22" version="1">MRTFHFLDAVCLFVVAAFILLETGLTLGNRWDSVASDEGLKLSEPDQLIVEYPGQNYGARSVSAEQPISKNKLGFFYYEVEILAHKGNSIAIGLGPTKPIPLQEEIGRVKGYAYNSGGIVQGHNVAGSSDFKGRPYIYEKPRFGVREVVGDDGVRNVVRDVVGCGVNLAKRQIFYTLNGALLETLDMNAADLDADLFPSVSMDYPETLDMRAADLNADLFPTVSMDYPGNKIKANFGSEQFKFDIAKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBZ0</accession>
    <name>A0A914HBZ0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HBZ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15942.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15942.t2"/>
        <property type="gene ID" value="Gr19_v10_g15942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF91">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="541"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15942.t2"/>
        </source>
    </evidence>
    <sequence length="887" mass="101011" checksum="F19D079D7A7B7B94" modified="2023-02-22" version="1">MTTKTLDKLKALSYLSYEKLKSAGKMDRDSLRTLKRMDIPKRFKYFVEVEREARMRVQEGDEEEAYILYSRALEIYRLINDSSDDKFKRSKEGRLYFETAMRITTDFEQVASSLQDRFKLLHPDDLLPTITSSNSHTDELTPAEWSRNHADTVFKTYVKPIELVRYVEKGMNALVLDYRENQGESIEYKNKHGSMKVVHIDQRDVVFGSLLHSIVKALDISIRPILENISHFDVVVLLGDVNDITKKKGSKTVILVEALTTYNFNHKLKRPPVIIEGGYENWKHAYPVYVTETYDIPRFEKSFDEQFTTWIVEARKANELRIYYPSLSTSVGVSGLSSEVQQKPLEPSRHRGRESHIEPSDVLYPSAAPTKPAIASSFIDTNISTLSDLPIHNDKKTVDKYKQISNKTTKIPTIDRSNKPSVAKSLTDQPLQKLTFNDKECRDAHLNKENFAPTDASRSDPNIPNRRRLPDGTSSAPSHQQPTRPSIPERINRNDPALRQQQQPQQEESTENYFQTSYYLSKTKISQQSASERRKTMSGHTGLVNMGNTCFMNATLQAFFHTPGFSDLFRNGNVASFVNSNGNFGTKGIISGCFSALLDLVWSGDYSAIRPQFFLEVFARRVNEQLADRRQHDAQEFQIFLLDALHEDTNRVDMRRPFEQNYDSSNLLASAQDFFTRSGQFSSSPVNDFFNLTTISELQCKTCNATSVRFEAVTQISVELPSTDNCLKLKDCLKAHFSTTTLDAPWNCPRCKSKQPATRSTKIWKMPAVLIIHLKRFSLSARCFVKNEVEISFDINGLDLSPYIHQKSPLRSAKYNIYAVTNHSGHLNSGHYTSSTINLASAGRDWLHFDDEHCTACSAPSSTSKQAFLLYYKLASPHGHDPNKAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC94</accession>
    <name>A0A914HC94_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC94"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15280.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15280.t1"/>
        <property type="gene ID" value="Gr19_v10_g15280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001:SF3">
        <property type="entry name" value="RIBOSOME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15280.t1"/>
        </source>
    </evidence>
    <sequence length="1259" mass="147229" checksum="DDD7802E3D1DDA6D" modified="2023-02-22" version="1">MAPKRQNEQFLEESQKPNFGDSSKENNGPRKIKQEKPENDVIILDEDEDDRKPLVEKSGPSKRGRKPRWDKQQQQEPEELPPRKIRANESDGEEKSQPSVFDYPTIFWKLARPKYGIFTFMCKDCQNANFLLGDRRFMLSPQNGEGRLEFTQTFCRDCAKLNFDCTDLIMKHQKRDAPTKNGHYHPYTGGNWATVGTLEKQYVIVHLRDGRKYRFRVPSGSFLSPQQLERGIHHGMISEMERLMTRKRAALVEEEGELFDLEVVEEAPLLSVRNETEAQERERAQREEKERAAYEKENERLRRLEADRKEKERLRRLEEDRKETERLQRVEAEQKEKDRLQSENERKAKGQKWLEDGRKETERQRLEAVRKETERLQRIENAPKENERKEKERKENERKENERKDKERKENERKENERKENERKENERKEKERKENERKENERKENERKENERKENERKKNERKENERKENVRKENERKENERKENERKENERKENERKESERVGKLKQESASQDKNKEEERMRRDQERKFKLRELEFLKELKPYRGGWMRLAHGKDPTPDVHYLHEKDEYHFANAVDKYRIHHPELPWDLPAFNPSAQIQRNIAEFKGLFEREGYDENYGSKTREEKQELIALIKGFRFYYMEDIGRFMLKIFDNKISHITLTDQLAYVLGYEQEQQILNEDLAKYSVDLGGGVSHLCIYLNSGIIESMIFGNTFANLLQVIAVEGKSGSVFYQQTGSGPIAYFEGLPTFQRGYGYFLGVPRQKGAGVGAVLRNLWRYLRPMISAAKPYAANIATELGKEGLETGARVLNQVSKGGDIKEALLAEGKEGAKKLLDKASSSLQKGRGKRKRRGKKTKAEIILKPFDVIHPITSYIDLSKVFVFTEFKIKKIAEDGLLNNIGPSDSVGLIQMPGATFIRNLKVHINQREVYDSNQLYSYKVYLDTELSYPIAAKDAYFGVAGYFRDTDLSKANDKRRKPLAESKAYQTISKLSADIFNQDLYMISNVEIDIELALQSDDFMLHQEKEKDKFVLEISDCRLIVKTVDLMDGLSLDIARKLDVEPARFGIRKSFMKSLFITGGRYDFSANLFTEEVPRRVIIGLVANQNYIGHKQKNPFFFNHHNVRDIELTASGRTYPQYPYNLDYKNNNYARAYHDAQEHLGLACTTESNGLSYSMFKTAFCLYVFQMTNSQEDSPGFELIKEGCTAVNIRFSEPVPPEGVTLIAYGEADGLILIDRPSWQAGFSLVRDLGQVANRGLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCZ4</accession>
    <name>A0A914HCZ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCZ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15477.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15477.t1"/>
        <property type="gene ID" value="Gr19_v10_g15477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000222">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15477.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16137" checksum="D7BBC5A5B9B87133" modified="2023-02-22" version="1">MFERRRFAQCYRTLFCLLCGDSLDTNGAALARHLVAKGNKEHIHHQYFAATLLKLDSAIAQPKVPVQSFEIFVRTLTGKTITLEVEAGETVDMVKEMLEAAAGYPSWDQRLIYSGKQLESGRTLADYNVQKEATLHLTMCLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDD6</accession>
    <name>A0A914HDD6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDD6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16468.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16468.t1"/>
        <property type="gene ID" value="Gr19_v10_g16468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16468.t1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52758" checksum="8A4DFB864C14774C" modified="2023-02-22" version="1">MSSILRRTRLSKICYYLLGSAIVGGGAYGAYASVVYYQAEEQRVMKAVEEQRKLDESLSKMALELETRRIRDTTKAEFDARILEERKMWEREMDMQLKRAANAHAEHLERVIKTQKQLHDVENQQLNEVTKEQRVEAVEGQRKDESLSKMALEPEMGQMRNNTEADFDARILEERKMWEREMDMQLRRAAIAHAEHLERMIKTQKQLHDVENQQLNEEAVRIERNKFAKQIGGAVTKLSAIEESLNSRAAMDLENKKAKIYWTICQSLMDTLVNGGCTTTTTAGKGTKTLYKTSLKEVALLKKLTENDAFAQHICKHFPQAAIDQGVPTEQGLKQRFDRVYKLARWTAQIGEEGGGLLKYIASWLQSLVTFELPTPSFAEDRINVERYEPYELLSQIRHFVEQRDLANAVRLANLMRGEPARVLRDWLNDAKYHLEVRFLIELLFAHSQAAGIMTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDM2</accession>
    <name>A0A914HDM2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDM2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15660.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15660.t1"/>
        <property type="gene ID" value="Gr19_v10_g15660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15660.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23004" checksum="A18A4C97118A2CDC" modified="2023-02-22" version="1">MLPGGDGGGGWRCPTDVCLPPAMFFGLLAGRPATQPTTANRSSSKLTTDGAAALAKTLYTTTHFCFGIWPNLDLIDGKRSHFSITSLCHANANAPNRKKKQMSTTITGSGSFWSLFFCAMLLQNMFTIVCMVDMKHNGGVHQSSRGERLRANVNRKNAAIATAGITALAGGAIAMNKMNKRRANANNDGMPQGPMPMMPGMMAPHPQPNHLIHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF42</accession>
    <name>A0A914HF42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16789.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16789.t1"/>
        <property type="gene ID" value="Gr19_v10_g16789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16789.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12970" checksum="6E9BCF3139F77554" modified="2023-02-22" version="1">MFSVEWRHNDKFKQDKEKRPAADVYDVMNNGWYGMCRRKCFSSSGWHGTFIHLLPPLFRSVVRNLPPPFSRHARGGVLFGVNWIIKFGRMGPKWPGNGTMKCHAKWRFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF60</accession>
    <name>A0A914HF60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16580.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16580.t1"/>
        <property type="gene ID" value="Gr19_v10_g16580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16580.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="10156" checksum="6EC439B5F5692BA2" modified="2023-02-22" version="1">MEMKKRPEPPKRIEMECKIPEEAGRETNLKKPEETKTEMILVPEKMEMKKRPEPPERIKMECKIPEETGRVTNLKKPEEEKVKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGU4</accession>
    <name>A0A914HGU4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HGU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17235.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17235.t1"/>
        <property type="gene ID" value="Gr19_v10_g17235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17235.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33104" checksum="DDB581AB788381D1" modified="2023-02-22" version="1">MDLVYHEKQIGRMCAQHALNMLLQGHYFTPDSLASIARELDQREMAMLRDESQFQSQNYDESGYFSIQVITEALRRQANLHLEPLESPNVLKILQNPSLAYAYICHLEDHWFSIRKIGTTWFILNSLFKGPRLVSESFLELYITQLHAEGWSIYVIEGELPACAAETVPREFWNETRRTKKLESDIEKAIALSLNEAQPFIVTKTSDEELFGTATPVVSQAEELDIQRALEDSLREANKANSVRSAESLLVGEAIRNSVLDLNSSSSTSKQTNEDEEDPHNQQSCSSGYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI47</accession>
    <name>A0A914HI47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16845.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16845.t1"/>
        <property type="gene ID" value="Gr19_v10_g16845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16845.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10802" checksum="EFD6D42AFBFFA1F2" modified="2023-02-22" version="1">MLRPILIAEGDELKFRILGCQWLLCSLLDFAVCTRSRIGREGEANEEKMAMVRELGKILFGLHQIRNQLSALQEGNAPYGGGPTKSNAPRQSETEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIM4</accession>
    <name>A0A914HIM4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17515.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17515.t1"/>
        <property type="gene ID" value="Gr19_v10_g17515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17515.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25777" checksum="4CE49DCC354C771D" modified="2023-02-22" version="1">MQHLRCVLVGDPCVGKTALIVAYTRNGFCERYSPTAFDNYSVTVCVDGNPLRLDLCDTAGRSEFDSLRPLSYSGASVFLLCFSVTRPSSLSSATQRWLPEIRSLAPSAPILLIGTQSDRRLLSHRSDTVEAKLMAQLTERLQMSNCLECSAVTQHNLKEVFDLAILQGLCHEQKVSPSRIPPSMPKAAKIALPEGVKKTEKREIGGRGGTGGTTTTKGGTLKQNLLRLVSITKKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJJ1</accession>
    <name>A0A914HJJ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJJ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2057.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2057.t1"/>
        <property type="gene ID" value="Gr19_v10_g2057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2057.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12317" checksum="0207FB5E6A578A9D" modified="2023-02-22" version="1">MDVQLQFISVPSILPVIVTAVALFLATNGPHNWPALWQEFTNPPPDARHAIRKPSPYYFVQLSSAEIELRRAQLMSYVQVYGIPLGEQQSEDGNGCKFTTIADTKMLRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKE0</accession>
    <name>A0A914HKE0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKE0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17431.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17431.t1"/>
        <property type="gene ID" value="Gr19_v10_g17431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17431.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22407" checksum="ECE998032CE2585B" modified="2023-02-22" version="1">MRPPRVIQLQLACRIGGEQAEQCGDADRARDLQQQVSELEEKAKKIEYQRTKSLSAISAINQRNRDHMKQSFLGTGLVRTEDREKDDDPFTRKSARMKVVAGAARSKTAAGGNVGSSSISTVISSRGSLSSSSDTSSPSKKAQLPSAHDLFNAHGIDINIDIKVPAVAGGSFRAPPIADSQAPRMQQKASSSRTLTLEEYKKKRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKR2</accession>
    <name>A0A914HKR2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SEFIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HKR2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g238.t3">
        <property type="protein sequence ID" value="Gr19_v10_g238.t3"/>
        <property type="gene ID" value="Gr19_v10_g238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030368">
        <property type="term" value="F:interleukin-17 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039465">
        <property type="entry name" value="IL-17_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013568">
        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583:SF7">
        <property type="entry name" value="INTERLEUKIN CYTOKINE RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583">
        <property type="entry name" value="INTERLEUKIN-17 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08357">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51534">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="SEFIR" evidence="10">
        <location>
            <begin position="516"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="851"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g238.t3"/>
        </source>
    </evidence>
    <sequence length="916" mass="103452" checksum="587DF229C389B2BB" modified="2023-02-22" version="1">MCGVKYLTSFVDSLPPLRLLRFLIASAFLFRPISANCSHHFFFNDGRPADGNNQTDEQQRQNILWTFLEDTKQCDDELSSLLSTGNSSTVQQEQQQLDQRLRPCGNELLDIELAPHSVFPVGKNILPYVQLNISVTTFLPVDELFIRFRCIYAPNLDDYLCHNHNIQREKWGRMIWPCRRLRIDQKQRQFHFSYTCFRLFSLSQYSIEFFVLNRNEFCRRELIVTIPAEGQLDPKIAHFYEGIRSDQAAHTAPSWSPLLALDTSFSESLIVQLHPSEWLMQSQQHRHSTVSVAAFSIISSSSPASSSQQNNNDNDHQHHQTAADDHQHHSSDQITNTDDYSSDNLTLLNRHQQHNEQRQQLFLLSRKVPFLGRNDLEKKSRNVYRWAWSDMDAGNYTLFAFVEPGDGDCRLACRHPRRNSSNAHQQNGINDQNGRQKCRICPHTALNFTLAVAKHSTEWRNSLLMTAVARQASICVLGLLFVLLVALVIAFLYVRIWRPRAFARLPPRPIELGAHCPTVLVLYTDDCQAHSNAVLTLCRTLEESANVKCLVDQWAFLDSPTLRPSLWLVDKLAECDFILVIFSACSTRVMAGEQLVQRRHFPDLFNSGLGFIVSRIREIASSEGVVLPQQQQLNGHLQSRANAGGSSEEGVPPRHFHHGNHTAKRAAGISLLNRFIFARFASADPSVIPPFFTSSQFGVGRGGPLVLPDQIGLLIARLHGVVDTADASFPSDPNSSSRRTHCRRFLHEADLSQLNSALEELRLYVETNPTWMGQRFITTTSNSREMGGRFEAKTGEEKEEATENIGGPVNNSVAQPQQLPEQPDGTVQIRVPTLAEQGQIAERYGLLTVDDEGEEEEDGDEDNANGQQKRILDASNVPLAKGPSSKRYRLLMVGEEDEEEEEGRGRPYASKPSKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL69</accession>
    <name>A0A914HL69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2159.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2159.t1"/>
        <property type="gene ID" value="Gr19_v10_g2159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2159.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18834" checksum="1FD4865A98972A3F" modified="2023-02-22" version="1">MIVRLQNMRYIIKLPALRSTTIRRARFGTHDSARTIRRARFGAHDSARHDSAPTIITKNLSAPNRAALKRVRRIVRAESRCTAALVTDGPFERLPNICGPDICGPDICGPDFCGPDFCGPDFCGPDFCGPDFCGYSENRTFAARHLRPDICAPDICGQNTFAARHFAILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLC4</accession>
    <name>A0A914HLC4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLV3/ESR signal peptide family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLC4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2195.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2195.t1"/>
        <property type="gene ID" value="Gr19_v10_g2195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039617">
        <property type="entry name" value="CLAVATA3-CLE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36016">
        <property type="entry name" value="CLAVATA3/ESR (CLE)-RELATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36016:SF10">
        <property type="entry name" value="CLAVATA3_ESR (CLE)-RELATED PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2195.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18789" checksum="C8A52852771B3A20" modified="2023-02-22" version="1">MVFSSLATLKQENQVVPGGPDPKHHEDATLKQVKQVVPGGPDLKHHKEATLKQQVVPGGPDPKHHEDATLKQVKQVVPGENRVVPGGPDPKHHDDTTLKQENRVVPGGPDPKHHDDTTLKQENRVVPGGPDPKHHDDTTLKQENRVVPGGPDPKHHEDATLKQVNQIVPGGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM77</accession>
    <name>A0A914HM77_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914HM77"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2779.t3">
        <property type="protein sequence ID" value="Gr19_v10_g2779.t3"/>
        <property type="gene ID" value="Gr19_v10_g2779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="IMD" evidence="16">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="547"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2779.t3"/>
        </source>
    </evidence>
    <sequence length="985" mass="107676" checksum="EE8249F9A716CB69" modified="2023-02-22" version="1">MLTSGMVRELKASTSAWETFGCRAAKLASQLQQVATAFGSFVDGLQTISDSANSVNGVSRDIGAALTRFCLRQRSVELAIRKWGETLQKQCADDLGRRSGEWRQTVSDLERRHQRNCKRFKASGGGKHNNNKNRQQIEAESRNFYIELLHAQRAQCTEFVVGTLLPIINAQMVLLDEGAHIQPILDSLETSVNENDTAKLVQALLEDIDACSGANGHGMAPKRGENDDQLAWDQRIGIGMALGRAKSASQARLFGVSVGPERAMEEDDHSLNYGSTAMLTANRNSMPPPSVNSHQQQLFSSCPSSAAATISSSSSSAFVVGSPASKGNNCGGAVGSGDGAAEDIWQQNISRNVPSSHQRMPLPQPFVHHQMAAERADIVSPTLAADTLPQNQCQKPPMPAATTTAATNIQYDDDICWTFIGHPILCTVNKNHSKCIYCCHSGIARQFDAQHADSTDSGSHCSSALIAETLQQIDRLGLELDNYCDGLDELNNDGGSERVGDGSHRLAAPFRPVVGNNRQQTAAMAFAETASSTAVRFRSSTAAHAQRFVVPPPPPPPPPLPPQRRNSAISSATPSAPSIAELRSIGASAPFGPSLHQLAALHPKGAVPPSPSPMPPHSPKNGGFVQFCCHSVTGSATRPPALYRPAEADFGHGLLPVHAVHAAHRHFAFVFCRAILFAYFMVKFRFFPQIRPFFWPVLLLYLCWFAWDFGAPSRGSHFCPFLHNLPVWRHLANYFPISVVKTAELPTDRNYLFSAHPHGIVGSSSFIFFATNGANFASIFPDLKMHSVTLDLNFWFPLRREMIMGSRMIPSNSKAIEWVLSRPGGGFAVGIVPGGAAEAMESFPGTNRLITARRKGFIKLAIKHGASIVPVFHFGETDVFHQSKSGEGSTLRKIQNSMKRLTRISFPLAYGQSFLAALLSEERARKLPRWLRVGFFPYRRKIVTVVGEPMEIEKNANCDEQTVDKIHSAYCESLRKLFDEHKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMG1</accession>
    <name>A0A914HMG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2843.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2843.t1"/>
        <property type="gene ID" value="Gr19_v10_g2843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2843.t1"/>
        </source>
    </evidence>
    <sequence length="1005" mass="103812" checksum="313290F16D0314C3" modified="2023-02-22" version="1">MELQQQLNLMAQAIAIQNAPSASSATLTLLSQQSTANSATNLRGASNSGLSNMLDQYISATAAAAVTAIQQQQLQLAHLAVAPYNQQIATVSSTPATVANLPAPLAAYLQTAASSQPSPVDAAIQLLQHTQDNASSAGQPQTNPTMSLFSTLCPCNVSAIDATATTPCPFHSQQHNNDGGSSNSQQASANVPLVTIGGPPAQLGQQQRQHTAILVGVTQSNSSIGQQRLRSSSIIQHPPSSAAVGLAAAIQSHRMARSSLKRPSNGATTASAASVNGPAEEEGILSGTAAAVHVSSPPPLLISPNATSVRLSSGLGHLHDDDGGGPSRGPKLRRLASFGEMIASEGEITPRTQFSGHVATSDLTEFRAPSVASASTAVTSVAAAIVQLQQQAAVAALPSAVTFFSSLASASPPSTAIANSHHHQQQHNLLSHHSPTRDTALSSPPSVATPVADPTTASLAAELGTSSASLSAGVEQIVAAALNAATVANAAFSPQTIAAMAAATAFPPQNATAAPQCAVCAAAACQSRMGPSMAAAVTACSCLHHHHHHLHCHHNALVPPPPFPVCSLCNYVASSGSPSPSTTTMPQLQNQHSSNSNYLNNSNNSCINATGTSFVGNSHGTNRNNASGGVSTSLQPTAQIVPIAQRYLAMNPSALMGNNNNSGGGGGNERVPLSNNISANVNIHASAGGSSAAMAAAAALSPSTVTAMLLNSAAAMGQHNHLPQLVQTSPSIYSLQRNLAMSDFATSQQTLPNITSMQQSLLVNRMAQQEREREAINHFYQQQQQRTAAVNAAAAAAAASQQHHLMRPLIMVPRLPSQMDLANVLLLHNSGNVGDAATLVLNGSTNAASALAHATNPHHIVANAMATATAPEPQPVGVSLDQIKKHSQKLAYVKDPDVPEQERDRCTVCLADFDTGDELRALNLSSMPSGHGQRRCGKQCDGSRSCRHAQCVCSSRSGFCNVEYNELLIMKVDGSCIRDREDSVDFEDLGYDFCCDNSVLYIQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMU4</accession>
    <name>A0A914HMU4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2044.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2044.t1"/>
        <property type="gene ID" value="Gr19_v10_g2044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Fido" evidence="13">
        <location>
            <begin position="77"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="170"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1170"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2044.t1"/>
        </source>
    </evidence>
    <sequence length="1571" mass="177876" checksum="8EE62C109F2D3E85" modified="2023-02-22" version="1">MSKMNTSMSKQVENDDAETVPEDMDDELDSTEEQRGRGLEAMGHETHQRFLRQNSPFSCDISYASCLDEPKFLGREFTIETLHALQTVIVGEANSKAGSFREWNVTVDSFEPCDFSQVQCKMAEFVEWVNSELKKKTLTAAELSAIAMHKFVFVHPYVDSNGRTSRLIMNYIMRRLGATRFMKVGRVDHVHKGPLVVKVFVIIDQQIVVEPYRDQLLQISRRLIKHPNFSPINRVFVTSRAAILCRPFYKSTLYDRLSTRPYLTSIEKRWIAFQLLKALAQLRIALVRHGDIKPQNVLVSSSLWIQLTDFAPFKPALLPFDNPSDFTFFFDTDRRRHCYLAPERFRDSEELEARASAVAGDFPNFYECLTEAMDIFAMGCLLVELLSDGRQIAFNLPQAIDYKNADEHTAKFFLKRLLSAVPDTEFRPLIAIMLDRDPKRRRDEFLKLSPCSSTVLFPQIFERYLYNYFKELQSIQSADALITKLFVERDNYMALLRDEDAANSVLFINIICAALRSCCSLTAKMDALSLLHQISKISTPVIIFERIVPYLAHSISDHFPLVRAEAILILCDILSTCANSIPPDECRLLIDFVFPKLCPIVISSACLPRIALATNLGKLAQISARFFEASVARMRSESPEQNQPEHGGGGCSTTTVQQMSSRLEKFLCEEKRLLLETERSSSIDAVTEFFVTFCGCTDNEVRRCLFQPTNLDLLCQFFGASRVTDVLMHMITLLNDKHDWRVRAAFFEACPVLAQHLGQNRNSKLMPFLQQGLQDCEEFVVLECVCCVHALCRRQLLPKATICELLPDLVPLLVHPNKWLRIALVNILTILETDSCFTIADIYCKLTPLVTTFLRHPLIRLDCRDVLYETLVQPISRQIWDFICEQNNSAELITLIEERKTLEKLGGATKGNSGSNNSLLFNVISNVATMHHFDEKLNVADSKLPKGKSTTGGGGGGTKIDGLLRKLHGMGLSDQDEDKLLAFKGMLSRMDRFRREHAGRRSYRADKSSSEKSRIRLHELHGIRRRIFDLDKGVHLSGPTVLNSDTQFYVDRFGAQRLLFSASEFIEPAQVVDLNDHYHPSQAVDDSSSARILLEDTLRHKQKRYADQRRITTNSGEANSELVAERIAAATESLELGSAGTKHNGIGADDRERRTMARARRPNIRMQIHLHEHASKVTRLAVHPDQDHFASSSTDNSVKIWSSTSLLNNSQPASMSLDTLRYSHAINACGFMGDQGGHLVMACADASLQMFDIERKTLLKSVQLDREAEGPVSDLYCVEHLIYALTHHSSVFCYDLRIAPKKGRNAIELSSVWQRRIKNSYGLITSFCIDTINQHWMLLTASSATTKNMLLWDLRFAGLEVCSWSHPSDRIIPLRSWALPNGSRCDRALTNCSREAELSVWDLSTRSRTDVLWPSTEAPLTYKTEMVSTAVAPSMIDGSHIIFTGDSEGSLRCWNLRYPNASAYLCGPYRRHLPSGDLNIGDLQQLKSPSRIVYRQMQITDSVLRVQAEDRSQLISPEAENGTLGDQSHTHRMLQHAPEAHWDSITDLASLWPHLLVSAGREGVIKMWKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN70</accession>
    <name>A0A914HN70_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HN70"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2701.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2701.t1"/>
        <property type="gene ID" value="Gr19_v10_g2701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037963965" evidence="2">
        <location>
            <begin position="22"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2701.t1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41082" checksum="D4F81283B5F5BF1C" modified="2023-02-22" version="1">MEEFWILILVLFFATYSLDKAESVQLEELEELPLQTFDELFVDEWWDKDEAESVQLFDEIFGEGWWDNDKADEWDKLTLEQNFHHQIDRQNTKIGQIKPNSTDQLGQIEPNSTDQNPPLKESDHTGQIEPNSTDQNPPLKESDHTGQIEPNSTDQNPPLKESDHTGQIEPNSTDQNPPLKESDHTGQIEPNSTDQNPPNTEADHSDNAKNGEEMNSNEKRNIVAKFHGMKDDFKQKGKYSTKEWVQIEEKIDKTVAKELGLCFATIYNWKSELYQSTNKYAHDKPKELMKRYYEIKDQNSKIIDKDIAKMLKIGNATLYKWKKQFNKNSFDGHSVEENAAANVQEIGNSNSRIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNK7</accession>
    <name>A0A914HNK7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5'-3' exoribonuclease 2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Possesses 5'-&gt;3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with paxt-1 (via N-terminus); the interaction is direct and results in stabilization of xrn-2 in the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g280.t1">
        <property type="protein sequence ID" value="Gr19_v10_g280.t1"/>
        <property type="gene ID" value="Gr19_v10_g280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000001">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="14">
        <location>
            <begin position="324"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="467"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="946"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g280.t1"/>
        </source>
    </evidence>
    <sequence length="1437" mass="163245" checksum="504E49EF3F85D346" modified="2023-02-22" version="1">MGVPAFFRWLSRKYVSIIVDAVEQRRREIDGVKIPIDATQPNENYQEFDNLYLDMNGIIHPCTHPEDRPAPKTEEEMFILIFEYIDRLFSIVRPRKVLYMAIDGVAPRAKMNQQRSRRFRAAQEAAEKRELIDNVRKRLEAEGIPLPPPRKEEEHFDSNCITPGTPFMARLSVALRYFVHKRISSEPAWQNIQVILSDANVPGEGEHKIMDFVRRQRASPSHDPNTVHCLCGADADLIMLGLATHEANFNIIREEFLPNQPRSCELCGQYGHEVEHCEGLARAEAGPDQADPLKKEKSFIFIRLPVLREYLERELFMPNLPFPFELERAIDDWVMMCFFVGNDFLPHLPSLEIRENAIDRLVKLYKEMVYQAGGWLTENGVVNIGRVKTIMGRLGEVEDEIFKQRQMKELRYKETQRQRKQQARNAKAKIMPYNASLIAPTPLGQQKKMSGEQMRKLAAGDRMQFAKMADTASSQKLQSLLTPVHRQSQTEGDRKRKLAQNSPSQSPNGAPPAKTFKDGGEGDISSGYAESTEKRTIKIETPSGKPVSLAKGAVEALANDSDEEEAHDEIRLWESGWKDRYYQAKFNVSETDLEFRKKVSCAYVEGLCWVLRYYYQGCASWKWFFPYHYAPFASDFELIGDFEPDFNTPTRPFNPLEQLMGVFPAASRAHIPEGWRWLMTDSNSPIIDFYPENFEIDLNGKKYAWQGVALLPFVEEKPRNTTGPDRLFIGAKHTLFSLVHEVHSEGSRLKQEEETKATPATEMESVEAADGEGNGETKQQIDETIVDKSENGTSSITGVEEKKWVHIDAVKAYGMSGQISHDVDALEYGETHRSLFRNSLEFGDINKNACVMVEFLDPQFPLHFIFKANRLDGIKELPRVLKPQDWDHRRPFQPQIGFSRDIPRANLSMTGHRTLNHHINDNRRSCPASLFAVQTTPPPTQTLPWHISPSAQQQQRHSGYTHHNAPQQWQQQSMYFNSTAQQQQLPVPLFSFGQMAMPPPPPPPMPPPQNWINHPPPQMHPHAVPTQPAKVANQKKSKRRKPEAITMGTRKRMGMFDHAKYSKPVLRSITEPVQKAVNRDINKLLDYGAAAVRFRRPEEKQPQQKRKLREMMSDVSVVEDSFDEQEDEVDRQRRKKFCPEIELNKPPVILASSFRPPERPMGLGRDPTFIAVRDALLKACPVKDSENAAPGMDAEERIAMLLNPGAQQRTPIQIQQRSHLPESQPVKSAFPTKCPLDRIADRLMDSFPSITLKNNEPQTLVDATFTMAKRALLAAQERQAMNGGAVTDGECSGIAPSLDLNPFKSLKDQTVCLFHTSEGEKDFYHDRSREVSTLDESPTADIVDDFLFHCASQLTSTKSTQRTSIPRIFDDGNPQTLCDFFESVSGVDQSGVSGSTEFDPHISYNAESQAFFDFFGSASRADQSGVSGSLDFNSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP08</accession>
    <name>A0A914HP08_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP08"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3307.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3307.t1"/>
        <property type="gene ID" value="Gr19_v10_g3307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037064551" evidence="2">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3307.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18727" checksum="9459CF69C11633A5" modified="2023-02-22" version="1">MNEFWILILMPFFATNSLDKAECVQLEETPLNPIDEIFGEGWWDNDKAEEWHKLTLEQNSLHQIYRQNTQIGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIGPNSTDQNPPLTESDHSDNAEDERKQLGISFVTIYKWKSELGQSTPNNIPTVNKRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPL6</accession>
    <name>A0A914HPL6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g3260.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3260.t1"/>
        <property type="gene ID" value="Gr19_v10_g3260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3260.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17143" checksum="BD739F120D69B486" modified="2023-02-22" version="1">MGKNPLXSLGVALKALRTXXXFSELANILQKEMDDXXECEVAQDMLDGLHHPGRKFVFETRVARVKSDTPGITTDQPTPRIRSTTPSPELGARIRNLRFDNAPASQSTPDQNLSPSGTAESQAARSVCRTSRETRRTGRPSGKFSSAVDSEPSYETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ26</accession>
    <name>A0A914HQ26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2657.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2657.t1"/>
        <property type="gene ID" value="Gr19_v10_g2657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF328">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2657.t1"/>
        </source>
    </evidence>
    <sequence length="409" mass="40162" checksum="B20F68E5EF44FD06" modified="2023-02-22" version="1">MRGGDGAEEEASSLTTSPPLLPITTASAHSSFFSSDDISHSDQQDRPVRSAPLTAKKMGELPTGALTTAAILAITSFGAILIGVPLMLNDVANLQSELAQKSQVYMDMSNNMWRDIMTQGEQSRKEHANIRQRRQYGGVGPAVASSPVGSATASATCPQGPKGSPGYPGEPGQDGQPGLPGGVGVAGGGAAAFGSQQGGQCAPCPGGPPGPPGYKGKRGPRGEKGAKGSPGLPGREGQPGEEGPEGEIGLQGEIGEAGPRGPPGEQGIGYAKGEPGPKGEAGPHGEAGEEGPPGERGEDSPPGPPGEHGPQGPPGLQGKAGEQGPPGAAGPPGAPAEYCPCPERSNGQPGAIGPHAVAGPQGVASGPAGGGASSSPAAPPHVAGGGPAAAQQYNKYAHAAALRTRHRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ43</accession>
    <name>A0A914HQ43_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ43"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g320.t1">
        <property type="protein sequence ID" value="Gr19_v10_g320.t1"/>
        <property type="gene ID" value="Gr19_v10_g320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="3">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="5">
        <location>
            <begin position="139"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="658"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g320.t1"/>
        </source>
    </evidence>
    <sequence length="727" mass="81791" checksum="0A8106CA04C5A347" modified="2023-02-22" version="1">MSSLTCPPHDNDLRDSIEKFAAYVARNGPASEEAVRQQHRDNPKFGFLFAGEGSDFYKYRLLYEIQNLQQAAGTFIHPPPVGVQGPSFVPNQQTHEVEEQRIEEQIKALRNQIIESESNLKAHELALNSQKQAKVEALWTAKEDKRISDLIKQDSGSKETISNSKKWIFDNCNSDRLREIILTYLLHRVRERRSIDAFRLHVLYLINDWAHYCQRKKLDSIRQMLSRYVPKLYAYACSSPTAASNNSFVDKLEKLVGVWEGHKYFDDGCYKQLRNPSATMLAEQTATVAEQHQLAAEVDKEIGETLGGYTKQHKEYEQHVLTKVAELDASLRDYREKLEIERKRQAAEREKAEQLRRRSSRFDQTKPLSSVNSPHKIPSLLEINPPPHGPPVLSACLGNGPATMAPSFPPLPPAAGGPPIPHFTPPQQRQVDLIPKAPYYELPAGMMVPLIKLEDITYNSLHEKDLRLPPPEPPSEQLVREIERFYSALQLPPPVDCVRDADGWEMNGLLEHYIKKSEMKVKLEAKMKDEGKTFEDAITNKFVPPLPTENKKKSKPAKVDSRSPSSSSSSDSSSDDSSSESSSGSRNSRSRSSSGSRSASPQNRKSLSPTLKRRRRSRSRSPTPEDRPSFGGFAIPIKPAPKPAAISFKVPAMPLNRETNKGAQLMAKMGWEGKGLGAKEQGIEEPVGGGEVRDKMDQFRGLGSKADIYEEYRKQKSVQMAKKLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQX2</accession>
    <name>A0A914HQX2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g3420.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3420.t1"/>
        <property type="gene ID" value="Gr19_v10_g3420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3420.t1"/>
        </source>
    </evidence>
    <sequence length="1918" mass="201989" checksum="97757B01DE22B87D" modified="2023-02-22" version="1">MHKRQGPIKKNLHTKGTAQLNTKGPANSNKRPGPQKKRNKKSGPLAQKARRQLEQKAGHNKSRHQKKGAGPIQKRPGPWPKRQAPISTKRPGANWQKKGPGPIGTQKAPRIGTQKAGANSQKGPPITQKGRQLAQKGTAQLAQNRRINKAGHGQKAGQNGQKERQLAHKAPMEKGPGGPKKNHGANWHKRPGQLAHKRPANWHQKARRQLAPKGRRQLATKGTRRQGTLKVSHKRHRPIGTQKAPANWHTKGSAPIDTKRRRRQFNKRLRRQWHTKGRAITQKARQLAHKSTAPIGTQRDRRPTLANKRHAPISTQKAPAPIGTKGWRPIGTTKAPAQLAHKAPAPIGTKKAPSQLNTKGTGHIGPQRLLRQLAHKSKQKATGAKHTKGHPGPNWHAKGAGPISTIRAPAPIVHTKGSVANWHNKVTGRQLATQKAQAPIEHKKAPAPIGTQRAPSTIVTQKHAPIGTQKAGPIGTQKPAPMAQKAPAPISKQQKAPAPIGTQKAPAPISKQKAPAPIGTQKAPAPIGTQKAQAPISKQKETAPIGTQKAPSPITQKAPSPFTQKAPKQKAPAPIGTQKAPSPIGTQKAPSRIDTQKAPAPIGTQKAPSPIGTQKAPAPIGTQKSPPPIGTQKAQAPISKQKAPAPIGTQKAPAPIGTQKAPAPIGTQKHRRQLAHKRRRRQLANKRNRRQLAHKRLRRQLAHKRHWRQLAHKRRRRQLANKRHRRQLAHKRLRRQLAHKRHWRQLAHKRLRRQLAHKSHRRQFTQKAQAPISKQRQPAPIGTKVPAPIGTQKAQAPISKQKAGANWHTKGSGANWHTKAPVQLHTKAPAPNCTQKAQAPIKQRNRRQLAHKRPRRQLAHKSPAPIGTPKAQAQLANKRQAQWHTKGTVANWHTKGPGALAHKRLPAPIGHNKRHPAPIGTQKAPAPIGTQKAPAPIGTQKAPSPIGTQKAPSPIGTQKSPAPIGTQKAQAPISKQKETAPIGTQKAPSPITQKAPSPFTQKAPSRIDTQKAPAPIGTQKAPAPIGTQKAPAPISKQKAPAPIGTQKAPAPIGTQKAPSPIGTQKAPAPIGTQKAPSPIGTQKAPAPIGTQKSPPPIGTQKAQAPISKQKAPAPIGTQKAQAPISKQKAPAPIGTQKAPAPIGTQKAQAPISKQKETAPIGTQKAPSPITQKAPSPFTQNSVANDHNKAPAPIGTQKAPRQLAHKRQRRQLANKRHRPLGTQKAQAPISNKRHGGRQFHTKAPAQLAHKRRRRPISKKGNGANWHPKGSVANHTKGFGTQKAQVPINKQKAPASIGTQKAPAPIGTQKAQAPISKQKAQAPISKQKAQVPINKQKAPASIGTQKAPAPIGTQKAQVPINKQKAPASIGTQKAQAPISKQKAQVPINKQKAPASISTQKAQAPISKQKAPAPIGTQKAPSPIGTQKAPAPIGTQKAPSPIGTQKAPAPIGTQKAPAPIGTQKAPAPIGTQKAPSPIGTQKAPAPIGTQKAPASIGTQKAQAPISKQKAPASIVTQKAQAPISKQKAPASIGTQKAQVPINKQKAPASIGTQKAPAPIGTQKAQAPISKQKAQAPISKQKAQVPINKQKAPASIGTQKAPAPIGTQKAQAPINKQKAPASIGTQKAQAPINKQKAPASIGTQKAQAPISKQKAPAPIGTQKAPSPIGTQKAPAPIGTQKAPSPIGTQKAPAPIGTQKAPAPIGTQKAPAPIGTQKAPSPIGTKKAPAPIGTQKAPASIGTQKAQAPISKQKAPASIGTQKAQAPISKQKAPAPIGTQKAQAPINKQKAPASIGTQKAPAPIGTQKAQAPISKQKAQAPISKQKAQAPINKQKAPASIGTQKAPAPIGTQKAQVPINKQKAPASIGTQKAQVPINKQKAPASIGTQKAQAPISKQKVPAPIGTQKAPSPIGTQKAPVPIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR87</accession>
    <name>A0A914HR87_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR87"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3725.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3725.t1"/>
        <property type="gene ID" value="Gr19_v10_g3725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3725.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14947" checksum="1A49B7A7BAFD841C" modified="2023-02-22" version="1">MTDGGSTMEPKWRPGHIMESYCRRKLTKACAGRTTDALEHLAVAELGTKAALRYFHYRCDSWRLNKGISWSKLCRHVHVCSSLLWCRQRTLFVPFVDIQGGSNLYERIGSSSSKGDGLRLSGGTFIRFAEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSC7</accession>
    <name>A0A914HSC7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSC7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4209.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4209.t1"/>
        <property type="gene ID" value="Gr19_v10_g4209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="7">
        <location>
            <begin position="179"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="762"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4209.t1"/>
        </source>
    </evidence>
    <sequence length="963" mass="108915" checksum="3CDEBB1F6A8441CF" modified="2023-02-22" version="1">MDTSASEWDPRDFVVERYPKRSRKNKIDDLSLLDEPDLDNFNKAERLSKLPYSIKELLESDDYSQEDVVLELPVSDLSRDYIRQTGLLRPLLFNVPPEQLGMRMPDPQAFTVSDVLDLVGGDRRIEVVEVYEQKGSYMLLKEFIEYYKKSPSERTKLLNVLSLEFTSTKLAEKVSAPAFVSEIDWIDKKSAWARSNDFSTYPKVQRYCLMSVANCFTDFHIDFGGTSVWYHILKGEKIFWMIEPTEDNLVLYEDWILTGSENSCFFGELVSKCARVRLCQGHTLIIPSGWIHCVYTPVDSLVFGGNFLHSYSIPMQIRVSKSEDRIKIGSKYRFPHFKQMFWCYIAAIVRSATRRIYQKKLTEEAHIHLSQKVDSTTSNENDTSEAHESNLVCPPYNSSVDEKNGCLLPNGQTPQLPTDGEEICYDDALGNAVDGSLTFNPIQSVYDSQDQASFTPTQRYNLDYLNSLPPLVINGLHSLGDYAKKLLKSKQPEVVEGITRPHHLVKEFRALIGKINELGLPKETPVTLSVKLPPRDDKRKMKRHGIVDESVQKKALKKKNVLNQLTSSGTILVGGLPLPTHLNTPSSSTGFNPMGEIVKLGQKPMQSAWRKATNMAKPPPPTHIYQIKKRFEASISDEKSMDNSSIEFEMEKGIEAEESAMDTTFAKQSASDGINRDKKLGQKHRKPVPKLPNKLIEIHDDSPEFSHRSPLQRMKGQETKNLSNAFQPHNQSLPSFGQPNTNRNEVFGHPKNGNRWTCERGGEHTTGGFRPHNKSWNSFNGRGGGGQRERPQNGGRGGGFNQARNFSSNWDRNPSNRWNTEGNDGTIEGHSDWNSFGNQSSDDTGFFNSTINTSAAFSIPRESAAFDPYPTSTTSHKPMQQQQPQQKRQYEQGIYHQPPEPISTAVNELHHISQIMDAPSSVGLNEMSVDQIPLPSDAPRFLHTFSSEPDVDELENISRMMHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSU5</accession>
    <name>A0A914HSU5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSU5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3447.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3447.t1"/>
        <property type="gene ID" value="Gr19_v10_g3447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3447.t1"/>
        </source>
    </evidence>
    <sequence length="523" mass="60233" checksum="2AB922495E6E87F7" modified="2023-02-22" version="1">MEYLPAPPLENVLERLPHEALVSAPPRPQTKKPVVNNWTSTSSQGKIGCAWQRHRLVAGALKALFSMSLAYAVKGTKGMKIVADHFIFLLSARHLDYEIALHFKKIDNTTAETILTRFEMVDQSNKSKERPSICEESFVIDITAIDSEGKRKKLAGRGRPKEFSINYTIHQGATFELTNNDNLCLFRAFEFLRMKFVLPQQRFSEYKRAASWQLNDVRVLCGACNIDLDQPFYSVEEYGERIQAFYEQLHPGMFRLFCFETSGKMKPSWKTEVEDYQHELCVLFTEGVDGAAGHYDPIKSMGKIFNNNGNYCFGCEMPYLQPNRHNANCKWKCHNCQRVGNLFRGNCYNKNGTFFETCLACSKTFKSAECYQHHAKIIAQKAKRGKEGTTIEKSICKSSKKCPDCGVIYQIRLQDKQKGHQCGQKFCRVCLGFHAPRDCYIPYRPKAKKEKRFIFFDFECTTDFKPDPEILRFKHQVNFCYAHVTCTRCIEKDVWDKDLEKACALCGPLRFYSWALPVPEIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTP3</accession>
    <name>A0A914HTP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3874.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3874.t2"/>
        <property type="gene ID" value="Gr19_v10_g3874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3874.t2"/>
        </source>
    </evidence>
    <sequence length="918" mass="104820" checksum="E57C94F4DD3C05A6" modified="2023-02-22" version="1">MPTRANAVGIDLGTTYSCVGVFQHGKVEIIANEQGNRTTPSCVAFTDTERLIGDAAKNQMEMRPSSTMFNAKRLIGRKFDEPALQSDMKCWPFKVVQAEGGRPKVQVKVKGQDKTFFPEQVSSMVLTKMKETAEAFLGQTVKDAVGRWGNRRSERAAHHQRAVGHGHRLRRGEDFDNRMVFHFVAEFKRKHNKDLSSNPRALRHLRTACERAKRTLSGSTQASIEIDSLCDGIDYYTNVTRARFEELCADLFRGTMDPVEKALRDAKMDKSEIDDIVLVGGSTRIPKVQKLLSDFFSGKELNKSINPDEAVAYGAAVLAAILSHDNAENLQDLLLLDVVPLSLSFEPTGGVMTSLIKRNTSIPTKTSRTVTTYSDNQPEVLIQVCEGERVMTNDNNLLGKFELSGIPPAPRGVPQIEVTFDIDADGILNVSAQDKSTGKQNKITITGRLPKDEIERMVQEAENFSKEDEVQRDRLSAKNALESYCFNIKQAMDNDKKKVLDKCQEVLSWLRGNQAAEKEEFEHQQKELEAVCNSIITKLYQSAGGGMPGGPGGMPGRVAPTNLSIGTDDDENRRCSHRPPEHSYAEEWREFQQRLEQEHRQMHQRFMEIMERMEQQRRQEQQRREERQRQERLERQRRWEQQRQEREEQERRREQEHQQLMERLEREEQAEREQKEEERRRQEEKRRQEEERRQEEVRRRHEKIARARMQEQQLAEEREAVVARGIEAVQEAQKTQTFLRLDVQQLGNTFKQKMSASSSQPKHKDADRKQLVVASETSVEAANRSVVLCEMEVQLEKLELDTQCDQKKKSDVCADGAEEKEKGAMDEKGPAVTFVDNSALDNSAVGQLGTGQLGSEDNSALDNSACRVVLTAELYARRNTSQISSMRRNDVIATNGKRRPSPMNDYERRLLAHFVSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVD5</accession>
    <name>A0A914HVD5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="4 11">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 11"/>
    <dbReference type="AlphaFoldDB" id="A0A914HVD5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4330.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4330.t1"/>
        <property type="gene ID" value="Gr19_v10_g4330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 10" id="KW-0853">WD repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="146"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="634"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="748"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="832"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4330.t1"/>
        </source>
    </evidence>
    <sequence length="868" mass="97930" checksum="1B41864CC9540CD6" modified="2023-02-22" version="1">MNSRVRAHQIPHQWETKRRKNPSKTKCVVCSSTFGFFVQYEKCRSCKMAVHIECKKNLRVQDNCGLTQKHLKELVTQMVISKTQENWAPEIGNSRSMSDIFVNEDPNASDEQLIPKKDKFERRSWNMFSIRRNAAWKDDTIPMGEVEVISQIGIGRFGAVHEAYYYEPAHDTACFLNVRHENLVFFRGFYTMEQSRFGVVMEFIRGHTLSHILHDADQDRPALEFNEIMEYAKQICQGMSYLHTKHILHKDLRSKNVFVNERRIVKITDFGIFNIRRLSYPEGRNSFVVPSNWLSYAPPELLRLLSHRFEPFQFTEPCDVYSFGTIWYELLTSAFPFSHVPSDVIIWQVGNGTKTSITELNASHDAKALLIRCWHSKEALRFPHHLKMSNFVCAISGMEPELAVVSAVSENGTDPINGQKLDVANLVELKQDPGVRSMQKSLATASLPSLLKQLQDEWDATMLNNFTLRQELKAAREELTHALYQNDAACRVINRLSSELQSARQIIATLPHGRRHAESETEATDVEMRSDIAEDNTGADGLPGISDDLVKFFTDKYQDFSTARKQRGRNLPEALASVEQIQKYEEIACHDALHSASVTGITALDMQQNFIASGGMDKTIVLFDSATETIKNTYKGHQKRISAVRLHPNLQTIVSGSFDSQIRIWNTNEQNARNVIAIHERPITDVSLHPTGDFALCCSEDSHWSLTDLKAGRPLIKAESGDDDMQGICCGQFHPDGLIFGTGGKNSFPGHQDVVAAISFSENGYYLATGSADGEVKIWDLRKLKNLKTLSLYDVKQAINCLTFDQSGAYLAVGGSNVQVFQAKTWNNIAQFNTHTQAVTGVCFSEDSKTIVSSSMDKSIRVYAMPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW09</accession>
    <name>A0A914HW09_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HW09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4526.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4526.t1"/>
        <property type="gene ID" value="Gr19_v10_g4526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4526.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7380" checksum="4AB33C5A8652118C" modified="2023-02-22" version="1">MVNARRFRLLMDDEDDDVVGLSLMDGAVFTIFAFSSAATSSRSKHSQQTTFAPYPSSPSIEIEHGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWY7</accession>
    <name>A0A914HWY7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calpain-D</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWY7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4905.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4905.t1"/>
        <property type="gene ID" value="Gr19_v10_g4905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000010">
        <property type="entry name" value="Calpain 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF382">
        <property type="entry name" value="CALPAIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="14">
        <location>
            <begin position="235"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4905.t1"/>
        </source>
    </evidence>
    <sequence length="787" mass="88996" checksum="3D35443069561B18" modified="2023-02-22" version="1">MHTITKNWSCQRCTLINRINETKCRACQFECPSISGRSGFLQKIKFPRISLNSALERVDNAIDFVASAIVPKNGQNVQFYQPPAFLRGHPQPRADPAFSTANPAFWVLPMVTLPQPKLATWACPNCAQLNPASVKKCSWCETDRVTDVTISYWCCSNQRCALRQPFPPSDLKCPLCRTKTSALKSGCSKSMPQLSRPQTNVLNPSDYGPVEECQILTHTSTYRDILRFCENNRQGFVDDSFPHSNRSIGTLSQLERRDLSIVWLRPEQIVTRDNRLSRWSVFNDPQPTDIEQGLLGNCWLLSALAVISERPDILEKLFITKEYTHHGVYEVRLCIDGIWQHILVDDFFPCQKRSRQMVFAVGRKNQLWVSLIEKALAKTYGNYAILKAGRTVEGLSTLTGSPTLSIDLEYVDLDRDSRNAALDIAWAKLISAREARFLMGCSCGAGKRTVDEAEYRQVGLMSQHAYSLLDVRQTSEGHRLVLLRNPWGTFVWLGEFSREWPGWTQRLRRELPSGANLSAGTFWMPFERFVLYFDNVDIAQTREHSGGWVATRYLVDIGWDQQNSSIIRLTITEPTELCATLFQHNARTALDQVDIMLLLHKQEGEITPGELICRSARKIAPIVRTDDTFLLLGEYLLCVHSFSKFGDQMMPGTIVVHSSRKIFIEKLPTTFDSLHRSMCSLMLKEGVVQKSCSGTVSRYLTNEFAGLALMVDNHNVDCCMQVKSDCQSSTNVLSTRSSLLTVDSIPPLHRQIVALLTHFEPSQAFMNFPPLQTEAVGHLHGPSPIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXB5</accession>
    <name>A0A914HXB5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HXB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5340.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5340.t1"/>
        <property type="gene ID" value="Gr19_v10_g5340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037341020" description="palmitoyl-protein hydrolase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="5">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="5">
        <location>
            <begin position="146"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5340.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28268" checksum="95E83B1968A02400" modified="2023-02-22" version="1">MSKFSLFPRLIPTLALINVYSSAQIYGNDRETDGGDVANFGTSGFYPNAQQDESEVISRPPVVVSSVGRQSATLIFFHGMGDQGDGWAELFRSNFQPNLRHLKFVVPNAREMGGMTAWFEHRGFDDPSADEDREGLNAVTNYAHRGFSQGGPVALYSGLSYPEPLGGILCLSGFLLPKDSLPTQIRQIPGLNMANSAVPIFIGHGLNDPNVPFSVAVSTANALQRFDPNVILRAYQMGHSNCATELDDAIRFIKEKAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXB6</accession>
    <name>A0A914HXB6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXB6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4893.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4893.t1"/>
        <property type="gene ID" value="Gr19_v10_g4893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4893.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26971" checksum="9924F90D101DA335" modified="2023-02-22" version="1">MTSSSGAVRTRKRTVDHVVKKVFRRRVCLICFGFTVVFFVLLLAGATTLTVLNVEHLNEIKAFLRKQSSLKSRTDIEAFYEIECPIYDKKPSEWDVFETAFCNRYCDRNFKFEFMYRQLDPKKKFLTHKTTNRREAHYCPVYVELRQCQTEDGGHCEKKIFDKDVIDFNSTEEMRFSLLLMLLVLQFLFFAVAFVNGLPREVPPLLLQRLKRQDEVASDIIYLPMSYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXF8</accession>
    <name>A0A914HXF8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXF8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4681.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4681.t1"/>
        <property type="gene ID" value="Gr19_v10_g4681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4681.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10083" checksum="A654FE44C6D05863" modified="2023-02-22" version="1">MKKLANSSFVCGQLGKSGTQKTQFFGGRVQIGEGDDGKNDALIHVFKKDGAIPNGLALLQQRRQEEDMIKLVEEIDLNEDDNIESDFSIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXW7</accession>
    <name>A0A914HXW7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXW7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5135.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5135.t1"/>
        <property type="gene ID" value="Gr19_v10_g5135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5135.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="26220" checksum="FE832D0FFB123C22" modified="2023-02-22" version="1">MQSDDIVWNQLNKSHCSYKILTKAKKFCRHEYNLTGLCNRASCPLANSQYATVREENGMCFLYMKVAERSHYPGKLWEKVKLHRNLAKAVEQISTNLLHWSEYIRKKMRKMELKGRSPKIIPLQRKVERRERRREEKALAAAKLDNAIERELLQRLKKGTYGTMYKFSDKAIDRAVERVGEEDDEEEEVEYELEREKQRQFVEDFDESEEEEEEDIEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY41</accession>
    <name>A0A914HY41_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HY41"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4859.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4859.t2"/>
        <property type="gene ID" value="Gr19_v10_g4859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000067">
        <property type="entry name" value="alcohol dehydrogenase 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="207"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4859.t2"/>
        </source>
    </evidence>
    <sequence length="376" mass="40712" checksum="FFB22439A0058B9C" modified="2023-02-22" version="1">MGSCGKIISCNAAVVWAPHKPMSVERIQVHPPDAGEVRIKIAYAALCHTDYFFLMESRDQTVRFPIVLGHEGAGVVESVGAGVQSVSVGDHVVPCAFAQCRQCANCHDSKSNLCDKYFGMKNMQTMETDGQCRFECAGQKLFHFGRCSTFSEFTVVPEAQVCKIDSKMPLDRACLLGCGVPTGYGAPLNGCAVNVGDVVGVWGLGTIGLAAVMGAVEAGACHVVAVDPNEKRFKMAKELGATECVKPEEGLQKYFFQKFNGGLDIAFEATGNIKAMRQAFECTKRGSGRTCIMGVTEQELNIPTSLLLQNRTIKGFIYGGWKCRDDVPMLAQKYTEGKLKLNEFASWQCSLSEINEAVGRIARGDGLRSIIKMGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYY8</accession>
    <name>A0A914HYY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g577.t2">
        <property type="protein sequence ID" value="Gr19_v10_g577.t2"/>
        <property type="gene ID" value="Gr19_v10_g577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g577.t2"/>
        </source>
    </evidence>
    <sequence length="171" mass="19065" checksum="055E0C77A74D11B8" modified="2023-02-22" version="1">MDGQTPEGGGGRKTKAHATALLVKALIRSLLLLQRRRLPVLCPPARQRRKRLSPPLASPFSPPANLFLFPLFLHLPTARQLTPNDGRENGGESEENELHRNMARRREKISIFKNGCQQMHWLQNALDFCFLCHKSLSVFPHRFSRDFQRNAAGGMAAATAFTSLAGSPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZK4</accession>
    <name>A0A914HZK4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione synthetase</fullName>
            <ecNumber evidence="4">6.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HZK4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5535.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5535.t1"/>
        <property type="gene ID" value="Gr19_v10_g5535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="17">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="16">
        <location>
            <begin position="392"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5535.t1"/>
        </source>
    </evidence>
    <sequence length="670" mass="76735" checksum="F3585DFD6BC344C4" modified="2023-02-22" version="1">MENQVVKTRQNNKKLEHEGCLYIFHKLNADGDVKFWRCEHQHGDVKCRGRVHTSLNDVVLRQNNTRARPLFQPDQWSVHQRTLDGTDRTNNYAESYHRTLQHAFGHTHPKICSFIDKLREQQKMVDVNMEHFIAGNAPPPKAKKFRDADRRILSVLHRYIKCKSGATSTYYSTPTGPKNAGKSSSVSNEGFQLGKRLEECDELETLIQDAVDWAHTVSLVNRVREHRERSDVVEIVPFALFPSPFPRRLFEEAQAVQKTLQLLYFRVSHDYAFLKETLREAGETDNYLRHMLDILDDVNERGVKQPITLILQRSDYMCHVNSETGEYELKQVEVNLGAIGGNARTQGVSKVHRRVFSKLGLTNDNLPLNESCTATGEALTKAWKYFGDPLAIIVFMSYTKVQGIFDQRLVEYEIEKFSKQQIKIVRLTLEECGKKLILDPNDSSLSYNGRKVAVIYQRNFVYEWDWPTEKEWDIRRKLERSTAILTTKVGSNLAASKKVQQVLAEPGMLERFLPDVKEEMIQSVRKTFAGLWGLNKDDAETRAVIKRAIEHPEKFVLKANRDGVGNNFWDEQLAKKLRTLSQKERAGLILMEKLEPLRVTNYSIRPRGGTSQFESMVSELGINGYFLGNAKTMGTLDNVPRGHMLRTKPVDAREGGVGIGIGVHDSPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I002</accession>
    <name>A0A914I002_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I002"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6050.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6050.t1"/>
        <property type="gene ID" value="Gr19_v10_g6050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6050.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16191" checksum="CB140D6118137315" modified="2023-02-22" version="1">MATAEGVIDLNKEKDGGIVKRILCDGGEQGCGGGEQGCGGGEQGCGGGEQGVHPVKGDTVHAVGADMAGLEYALGEGTEQQLPDGVDKSDKKIGISKPSETTEQLQTEPKTSQNAPILSKSHKRRLRRKKFKECNSIQISKNGKKLFVPPYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I040</accession>
    <name>A0A914I040_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I040"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17009.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17009.t1"/>
        <property type="gene ID" value="Gr19_v10_g17009"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6085.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6085.t1"/>
        <property type="gene ID" value="Gr19_v10_g6085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF31">
        <property type="entry name" value="PAIRED BOX PROTEIN 2 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="215"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17009.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6085.t1"/>
        </source>
    </evidence>
    <sequence length="567" mass="61299" checksum="25CD3E702C4A469E" modified="2023-02-22" version="1">MIVATVDGGCRRTTDPTTAPSIGGAANPAAAHRRQKEHNCSINSTPLVTVPHSSLFGWPIQPQHQQHDTFRQNYALNVDRFTAASTNSSSNALQQQQQHFAEFNAPPLHTNAIHQHNSSSSSSSTSSCNDQNSSAYTQQAPPGISNGGVYELVYGDAKSVEASFSNSGTFEHAQYAFLCQSSADTSSTSALVDSLQNRTKISSAVAASIATSYASHTGVNQLGGVFVNGRPLPNYVRNQIVEMNSRGVRPCDISRQLRVSHVKPGVIGGSKPKVATREVTEAIARYKSVNPTMFAWEIRDKLVEEGICDSESAPSVSSINRIVRNKIQQSPYQQQQQPSYVHCSRNSSLVPPNGIVQKFPVTSTTQISISDCAEETYKNFRNQQNGSDRMKRRRDRNEETTTGREEVPIKRQRNDGGNGRVAEGGGQQRQIHVAGSSVPQWTAPSAGVGFGGTGGVTSADHNALSSTTSRCTDSIRGALSVSKRIDDGRSVPSADWLPFRSHLHTTPALAPNHLPPTPSFSPLRSLSIRHSKSLPAIPPGLSFRPLPAFCPFEQNYYSGRPPEAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I134</accession>
    <name>A0A914I134_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I134"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6322.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6322.t1"/>
        <property type="gene ID" value="Gr19_v10_g6322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF3">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037747909" evidence="6">
        <location>
            <begin position="17"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6322.t1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53150" checksum="BAA639CDD8B7F339" modified="2023-02-22" version="1">MFTELIVLFAYLLSFASPINDNQFVVVETKFGLIKGFVSILSPPIKANRQFNSIDVFFGVPFSAPPLNELRFEKPLPPKPWHEVRPALKLKAACVPHARDECKECSEDCLYLNIFAPHQQQQQLHSHENGNSTLRRPLFPVLVLIASGGFETGSAAEFGNYTDLGLRYVSAGIVLVSIQYRLGALGMFSALQGSCNFLIAFNAFCLVMFLPFMGVGVFKCSFVPIQTCFWWQFIPMFFGNLFIISTLAIAIDRLLSVLFSAWHSRHNTEFSYLSSVLTICVLYSTCIVYICYIAAMKPVDVLVLCLNPADAYRGQIGIALFSLSLTAVSLCIVCYLIIWRSVRKNRSTWNGTFTMKILSSLFVIILLISFGYFLSTMIRVIALFMQFSQFAYIVFVSSMFSVLAMAANAPVLCIFSSDYQIAFREHFPLLFHRSTEVGGGRFNRGTTPVPERIFSRTNVEEWPRREMGHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1M1</accession>
    <name>A0A914I1M1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6045.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6045.t1"/>
        <property type="gene ID" value="Gr19_v10_g6045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1382"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6045.t1"/>
        </source>
    </evidence>
    <sequence length="1403" mass="161447" checksum="7DAB3E142B70480F" modified="2023-02-22" version="1">MIKRAIASSRGAPLFPKKAILIQNFHEAVASGTVASFGAIPNNVMEYASGLAWLPMLTMTNMLATATSAAMVPSEIHEAEEQTGERVLNLINKGFFPKPDLDKLVTDMKAEEESKRHDWRKPISAIGAVIRESKQQKSAAADEKMSKKELRAKAREAQHEALERLVRNRVDRVMDLTKTTGMARNSMATGIVLSLTAGFAPFYALQEFGIISANIVKIILIIFNAPTEILSMSIDRIMSSKGGWDAKKNRRMVGLIMRKAIEQLKTPGQPMTEITDDEVYNVYYSNFIARRMNKFGKATVDVMTVGGKFLKFCGGQIASGAALFAKLPLVRNLVGAVRKIKDKLHNNFLPLLAQGPIVVNWNQDVIYLITYPRLSAMKGISVPVISPAALKLEAWLMLRKLPFYRIKNDFLLADLFGQRVPFVELNGTKIAGTVDQIIEKLEQWELAKKSKHLMMENVTMFLSGHERDKRKELRKKERYIRRLFDEVVTRCLMYDRDMSIQIPYDQHFLHIQIPENDMGFLGQNYALFKQLVPTLPRFYPKWFNKKLLLKTPAFWSVYFRTEAEKREYRHGMEILSEQDQLVKDLRDKDVPLAWRQIFQRYKRKLYNELTSQKVREYNAEIDRWQVKHRTEKVAKDKFGDQISSEQSVKYGDLKPDQIADKVIEAMGIAAKQLIQTMGGNNMEKPMMFLFGDKPTPADVSLFAHLVQLFETKLHLDKLTKHVDKVKKSKKHEQHVLLQFVDEFKKKLNIQKWDQFKYSDDSDKAAAPFNSEWTPPDELGSTYSGPFELKFKDVPAVERNFMVFDEVEAEQEAEEFGTEQAVEEEEDAENSAPDDETKEEQTEIRRLEREEKQRYTPKQIVTFAMFNEKHTWEKLDKKRTLYEEPKDPGNFLWRYPKVVSFVARRILMITDCNEADKIMDGMGGSWVAIMDHGLELIEQELVKHQPFADIFQNRQRKDNDFFFYTVTKFGYAKKRAATARALFHLMALHFCKKFANGTSGLYNDEEEQLPASSSPESSTDELPAQVHENECKVHKPLAEEQLKRIWKIEEAKALLTICDKIIKKIIDQVYQNHERLVKPIFTRSEVKAFLPINDALVKFPPGNGAHGGAYYMDRVLLYYYPDAVAYVLHALMDTLFKRRVVPLHFSLEYRYVRMCDDITLNNKREQLINEMDALKGMTSARKLKQLERAEMERMQREQQQTKQLTVEEKKNLVDELKNTTIARALLRLAAAFLCAGGDENETTGCGDVHLKKAFDELGTVMDDAQLKALKKHGELNKKVKHFIHQIIVNYNELIAEEELDKFSTKIVAELELLPKGPGFFERLQNEHQQMIRNPPKELEAEVKFELSKSAHSPDLQRMQQRSGFVGNLQAWWQNFTPNSSFDASGGLKQPLLAQPQHVGKSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I226</accession>
    <name>A0A914I226_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I226"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6147.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6147.t1"/>
        <property type="gene ID" value="Gr19_v10_g6147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="860"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="1040"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="945"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="797"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="969"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6147.t1"/>
        </source>
    </evidence>
    <sequence length="1153" mass="125381" checksum="A874A721BADFC2EA" modified="2023-02-22" version="1">MHKMFFYSELMMMHSSQDPSNSYPQHCNNNNAHQSPEGTTALPPEAVVAQQMISANVALLQNGGVKNEEVKKESTGEEESDDEEMEDEEVEDDDEEEEEEEEEESASGEEERQRHAAAGPTEGPKMHMAEPGAVAGAGTAPAGGELQTIRANLQILNHQMALLMRTLNVASCTCAECQDAQRVQHCVALPAANGNSSQLQQLHAAGLNMGGTSGGISSFAPGTPHNLQQQHQNLFSASSGGGTDVGSAGDSAPRGRRSKYCTPEEKKAVASYVQCHGATAAARKFNIPPAVAAYYHRKEFKKQGVAARRSSVSVHHAQQGQQLQAGDGTKVELGDGQQGDESGMEQIGQLWQNNYGGGYLRGRGRGRPKLIGDELDAELVEYIVQLKQTNPRAHITAAQALVIARKYIAEKAPGLLEENGGQVKLKITWAMKLVTRVQEREREIQLGLPAGSLQNLPLSGSAFSNAAVGGDQQQSSASSALVNELLGQNLMGNQQIDVNALLAAAAAENPQQIDLNDAAVLNLLGMAAGGSDLFSSNGGGGGTGMSHEHPGCTSTGVGGQSTSSAAAAALQQQQNQRYKQELAESDEAIRQLLSSLQGGGAEHVGGAVQHQHQQRARDGAAGAELSVADLSGHVLKQNAMRLNNNKNCLPLLIVFLTLHIILICSKEEKKDSTRPRGVSPQLAPLYQERAEFECLDGKKRIPFEQVNDDYCDCADGSDEPGTSACKNGQFYCANFGFQPQTLPTGRVNDFICDCCDGSDEWDSGIDCPNLCDALGSKAREQAKQSAEVQAAGYAKRRELAKEGAKMLEEKKLEAEKTKNELEELTELKKGAEEAKKEVEELEKEAKDSQEKEWEEAKKELVRLQAEEMFGKMEKDGDGKISSDELKRFAGFADGGDSSERAKELLKDLFKEDSEGGGDEQIDNTLLNFDAFLEKFEMAKEFVEEITEEEAKSAATTTAPEADEDKRSAEEEDDKSEESDDETRKKYDQQTRQLIEKAEEARKEYNEIADKVSDLERTVRDSESFLNVEFGADNAWAPLKGKCAELTTAQYVYILCMFDRTVQKERNGHAEISLGHWGKWAGPEDGNKFKAQLYEHGQTCWNGPERSTFVQFECGEELQLVDASEPSKCEYHFLAKSPTACADPEELKGEHAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2B1</accession>
    <name>A0A914I2B1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2B1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g620.t2">
        <property type="protein sequence ID" value="Gr19_v10_g620.t2"/>
        <property type="gene ID" value="Gr19_v10_g620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g620.t2"/>
        </source>
    </evidence>
    <sequence length="647" mass="73547" checksum="9EF3690F36A21612" modified="2023-02-22" version="1">MLAIGVPLRGLPLALFSFPLMAVVIKEKQFSTFGQLLFYSTFGQLLFYSTFGQLLFYSTFGQLLFYSTFGQFDVRRKRKNRTVEGEHSVILSDQVFLHSLDMENERIKLMRLEKEHAEWWEWLSARHERNLKLDARLQALLEANKRLESDNFFKDTVIRQLTEERDEARQAANEKDRVIEELRKRLDEALAENLILKRDLREQTKIAQDMLDRNDRLEKELESLKKSSIEKENLIASLYKRLDTAFDEIVHLKKALDEQIGITEYWRDKFFQMKNDNEQLMATPSGVGTFSRSLPSTAVGTFPSLKAELQAYYDARKLNNNGEQTDDAEQLNSNGEQTSTDQENKQFLLHLLIYSIFGLIMIAITLPFFLNTSMSVPSQSEHLSFKEQNSDTSIMSFSNSKKDPAYSSMFNSSQWLDNEVCPVSGSDLGPFDDDYMKFNSNNEQTEKDIFGIAVSEDDISGITVSEEDISGIAVSEEDISGIAVSEDDISGITVSEEDISGIAVSEDDISGITVSEEDTSGITVSEEDIPGITVSEEDTSSLSELKFTGDFSLSPTPEREDNLQQKKSEEMLHRAELVRSTCKFASRIKQKNSVTSSIMLSGSCKFFSSLFGLSQRLEDEDMLRDNQYQPEELVDDGVSSLMEQIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4S2</accession>
    <name>A0A914I4S2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4S2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7301.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7301.t1"/>
        <property type="gene ID" value="Gr19_v10_g7301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02389">
        <property type="entry name" value="Cornifin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7301.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10325" checksum="E4FA851040AD8AA6" modified="2023-02-22" version="1">MYVTLPIQQKAKEPIQQKAKEPIQQKAKEPIQQKAKEPIQQKTKEPIQQKTKEPIQQKTKEPIQQKTKEPIQQKARGFVCSFVQQQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4W0</accession>
    <name>A0A914I4W0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4W0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7542.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7542.t1"/>
        <property type="gene ID" value="Gr19_v10_g7542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF224">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="76"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7542.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="41944" checksum="7E683043AAEE4FF5" modified="2023-02-22" version="1">MRRRRQRREQNIKVPIHSVGRAKDPVPIELITAMTNLDRSAPIGGSPAAARRLIAPVPSALFAVLFTLLTLAGLLGNGLVIGAVCSDRRMRRSAMNILLLNLAFADLLNLLATSVEWSQTLPSWTCPLLRYSECMFLFASILTQLTVCVERFIAICFPLQARRACTRSNALLALLAIWTFVAFFATQRIKNKNSILVRYALCLNRFSLTDLWLAYKWAEFLAFFLAPAALCALLHSRLCLALSSDQFKLNRRRQNPSDHSNGKEWDERVVCMLLVCVAVQLLCYSPIQAMFLATALFDVVLVAPYEMLLLLNALALACSAANPLLYTLFSRNFRTRTRSMLLSTANQCISARVPTKAFDEQKNAAQSYRLGDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4Y9</accession>
    <name>A0A914I4Y9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome transmission fidelity protein 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4Y9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7353.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7353.t1"/>
        <property type="gene ID" value="Gr19_v10_g7353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7353.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13341" checksum="62820020BF40E021" modified="2023-02-22" version="1">MQIQLVKNADSLTEWMIIELQGTIELGPGARSLEGQRLGQLEWGADRKCASLTLGHQLLEGRLEALEKPYLVLNRDSLSLRKACEEQKVNHCDVVAVVRKKLVFSERPKPIIKAADHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I607</accession>
    <name>A0A914I607_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamin pyrophosphokinase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I607"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6943.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6943.t1"/>
        <property type="gene ID" value="Gr19_v10_g6943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase catalytic" evidence="5">
        <location>
            <begin position="51"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6943.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20289" checksum="FC0897A7865FD89B" modified="2023-02-22" version="1">MGEISAAAGRHTFAPFRLIRQHFDELAVILTNSPPSVVARGDVPFPPDWIRIWNSAKIRLCTDGAANRLVGLCSDGHLKVPELVVGDFDSITAETQQYFSQFPTCELRQVADQDSTDLSKALSALMERTCKLSGILLLGGFHGRIDHVLGALHVLLLHIQQVPQVPLFAMDDENVLTVLPEVVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6C0</accession>
    <name>A0A914I6C0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ligand-gated ion channel 50</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6C0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7026.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7026.t2"/>
        <property type="gene ID" value="Gr19_v10_g7026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000035">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="148"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="359"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="494"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7026.t2"/>
        </source>
    </evidence>
    <sequence length="652" mass="72549" checksum="42CD260E29F3D2DF" modified="2023-02-22" version="1">MANTEHGFYCPSASCSASTSCSSSSTRSPSSSLSHDVALVTLLPNRCHSDHSNCMLASSPSSSAAAATTATTSCCPMSCISPSTSAFRCASELAPRRCAPQTFASIRFLPLLLVLGGCFAAMCAASASVVLDRPDAARCTRNSINLGNIIETLMRDYDIHLLPEADGVNVTIELHVQGISKISEITADFELDIMYSEIWLDPRLSFKHLNVCTTNITLKSDFRARVWTPDTCIINSKGSSIHKSPSENTFVILYEHGLVWSNFRLNVKAPCKMDLKMFPFDSIVCQLIFESYSFNTEEVRLVWHENPVTMMERVELPDFDLIGWGTDHQRLEYPNGIWDRAQVKFTFARRYGFYLFQSYFPTSLTVISSWVGFFFDVRSVSARITLGVSSLLALTFQFGNVLRHLPRVSYIKCLDVWMIFSVIFIFMTLVELSVICQLNRWERERQIGSKVLGHWLNQIRKTRKQTAGAGSAGSGAEAPERGVRKRFLLSPLKRLTHSPSPPPRPPNQNPLTPISRSATPTDLAAKEKSPPSPTIACQPYNNNIAAGGEMIRESSVSRWATFREGIPAGGAGGGGTRAADEALLSSRNRKPPRLLRSIWAQLKKLNPCLAEREWAITSVQVDRISMILFPLSYLVFNMTYWIYYLAKIGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7G9</accession>
    <name>A0A914I7G9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7G9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g762.t4">
        <property type="protein sequence ID" value="Gr19_v10_g762.t4"/>
        <property type="gene ID" value="Gr19_v10_g762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038009130" evidence="3">
        <location>
            <begin position="33"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="546"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g762.t4"/>
        </source>
    </evidence>
    <sequence length="1102" mass="120988" checksum="E27B467F8B00427B" modified="2023-02-22" version="1">MCKRWVNCCIILLPSSDACRLLLHLLLAVALAFGNAKVPPPTVPSSSLLCRSSLLINISRSVLNISAGGHRAIVTVPLYLILEYWPPQGQPASPFTLHGPPRAGDANFTIQINGTWPAVRYQYQLNAVFGTGQRNGTTADTVLLHKGIAYSSPDKPVLVSAAATERACTLAWAPPPALHLPKAQQHASDEQLQQSVYNYYMEYFPVASSDVVFFIRTKENSVRLRKLRASTQLSLYAEYFGVRSLCPLELAFRTRRTVPRYGNRTKALLTASATTPRSVVSQTSTLPPSTGTVLQTASTVPTRIGTVMSRLPSPKTNPSSSSTTSTTPFYKLNSTVPTRIGTVMSRLPSPKTNPSSSSTTSTTPSYKLDSTVPTRISTVMSRLPSPRTNPSSSNTTSTIPPAQESVELKEISAEKSEENETAAENETEEDSSEAERGDGEEADHEMSPKQLNETEPSIRIRQHGTRTLALAWRVPELVACDAFLVRHRPLGSMNARVSTQRTTTLQALVPLVVNACLEVNVSCLFENTVSPQWSARRVLDLRTPAPVQSVRVIRSYTDEYFQASVLIGFTLPPKAGPAHFQLYEVHVAWAPGKKVVGNQRVVFRGENISATDGVGKRAEGHVNITGLEPARLYTFAVRNVSREMPSQCSAPLGVRLITPPVVTSTVYAGKISTNSINVNFGESDESHPFEQYELHFASAGDDDAAPMSGGGDKFKNGSTTLIRRLAKNDPKSFTFNKLVPGKTYTFSLFTLLHGVRSRPVDANITTYPLKVSGFHPLIGSGYVRLFWTVLNEAHNFCRFRLSYTASAGPHLHSALSLELNGTINTHRFSGLDWNTFYTFTITVIMGPPSAEAESESEAVTIGMANRPRSSPQLKRYGSRELLLSFENDPEAFPERNGAIKEFAVIVAERVALERAIVATTESYKKDNEEEAQNLLETLGDLWELPSWHDARERADDAGDDKPWIAYRTSPSNYNPFARRGSSRLAQFIIGAEDCMPGRHRLDEMYCNGALRANADYFVRVRAYSVEGIAMETAWVGIDGAVPHAVSGKQSPEQKRLPCYMYLNGCNGRERAVGSNAAARICPFTRRLVTFSTAISTIIMIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7T3</accession>
    <name>A0A914I7T3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7T3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7538.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7538.t1"/>
        <property type="gene ID" value="Gr19_v10_g7538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="89"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7538.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34055" checksum="D7333D58039EE820" modified="2023-02-22" version="1">MDRLEFRDFPSAGGAASADFFNSDAVNKPPPDPTILSGNLLDVSSNEPQKDEPAKPHFLSLSFYRRFFDIDEQQVFSRLLNSAMPRRTGNFIADFVQPNPDLWGPFWVCVTLVFSIAIVGNLARFLQSYGSNALFTSDFSFVTGATSLVFGYVLTLPSLVYAFLWYHRPQGLQYSFFDLLCAFGYSLAPFIPVTALWLLFPFSIARWTLAVSAVVLTGSVLVLALWPTVREDPNRLTAFGFVLAIFLAHALLALCLKVFFLDQAVPSHGAQPSSHQPLHLDVSSMLSSTTREPPNALNNNGTTTIAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8D8</accession>
    <name>A0A914I8D8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914I8D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g759.t1">
        <property type="protein sequence ID" value="Gr19_v10_g759.t1"/>
        <property type="gene ID" value="Gr19_v10_g759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="56"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g759.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30039" checksum="57257A7451FAFA89" modified="2023-02-22" version="1">MASFYRRHIPNFSTIVEPLTRLSKKEKKFTWDKEQEGALSKIKELMSQTPILAFPDYSIPFHIFTDASVVGQGAALMQKKGDLFSAIAYASRTLSATERRWPPVQIELGAIVFALRTFKPYIYMSAIELHTDHRPLAYLQSKAQQHAHLARWLVELQNFNIKIVHISGKKNALADALSRLSESNLSPCPEDTTELQDIVEFPVCLSLTPFDRIVHNFDPIACSLTIRTTDGTPHQIIFPEYTFPYPFAHSFLTRSTRPSLEEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8K5</accession>
    <name>A0A914I8K5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8K5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7640.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7640.t1"/>
        <property type="gene ID" value="Gr19_v10_g7640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7640.t1"/>
        </source>
    </evidence>
    <sequence length="503" mass="54421" checksum="0E3C91398CA35136" modified="2023-02-22" version="1">MGEEYKQSSVESLFVCAQSANPHSVLVLDPFSGSSRWSLRGSELQQGTIQTAEPIGKNPSFLCVALADKPSLYTIPLLRVNVGPKSALHTNTSLRRLFICRRRQQTVHLGAPFCAMRISSCGHFLATASLDGDVKVFMTASLIAEREHGLSAAAPSALAAYSPHSLPVNDLCLSGGAHSAAALRILSVSADHSAALFSLPTQQILLRITADRSLTACCMDPAELRIFLAAESGLIGSVDICAQFNDQFVSFCDRKSSSSLALPPSVRHFEHQHNATVHKLAVSADGARMASGDEEGRYCVWDTANGQCLLGGIMQGRISALSFRLHWPTSDEQPKGNNIRQLASVTTLQRNLTIIRKLKMFSHWGEEINLTTKLSNEKVLVELLGALIKRINSGKRILSACLDDSNAHATEATGPKIGGKRRCVVTTEAPLTLKELLNKNNTEGVCSDEGAGGERELLLADQIRQLQRELARVVQLNAELYNYSANIALEDGYTDRNGRGCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8T4</accession>
    <name>A0A914I8T4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CC2D1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8T4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7777.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7777.t2"/>
        <property type="gene ID" value="Gr19_v10_g7777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039725">
        <property type="entry name" value="CC2D1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006608">
        <property type="entry name" value="CC2D1A/B_DM14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076:SF9">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00685">
        <property type="entry name" value="DM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="445"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7777.t2"/>
        </source>
    </evidence>
    <sequence length="616" mass="68577" checksum="D7B0F7DD180480B5" modified="2023-02-22" version="1">MDDLENDEELLAELLSLQGADGDVVVNKDNRKLLPLDEPGPHRNLASNVTPDVNDGIPVEETQQGEDMDVDDEDLLNELSELTGPCEEPSPTTKREFQTGPINGNELGQTLALRNVSPKRMKTLNEVESAPIEQERIPIDPTIELPKGPPPIPVRTASISLPEKVEFAKQSMQKPVLVETTEKTIESETLLENRAKNLLNRRRKLYLDRSLAAKQANDRPAAIEAFETVKMFNHALQAIGEGAQLSEEDLRQIPPSPQPYKSASAKNSTIKQQPTKDLPSSAVVSDKNYLIANAPMSEDLKLVLTRQLLLKKEAIAAKQNGDLNAAKEFLSLALRMDQMVEAAKCGVPIDVQQLPELHSNTKALPKAATKMGTIDEQTLPMKKCNLLEKELIKQIDLCEEKASKFQSAGDSKNTLLYEGLLQQSKKDLQRVQRATLGQAQLPGFKLFDLSLPVIELNSSIPDDKLELKIRKVEHLKLPEGWKPSDCALYVFYKFPFPHGNHQTGRTSTVKGTISPEFSDVFLLDINRKTKQLLRICKRQPMKLEGGFLRSDKLFACADVSLQELEKSATICSLFPMLEGRKKTGGNVQVEIHIKRPLGDAFDATTNAKRKWVKLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9D2</accession>
    <name>A0A914I9D2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9D2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8106.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8106.t1"/>
        <property type="gene ID" value="Gr19_v10_g8106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037931923" evidence="3">
        <location>
            <begin position="21"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8106.t1"/>
        </source>
    </evidence>
    <sequence length="501" mass="56141" checksum="776A7D5BF7BD50E5" modified="2023-02-22" version="1">MFPSSGRLLLLLILFPIFDAQQQILLPTAKKVEDVKGSSSSVLQPSPAQLVHSPSNGSEPSQSSTYWSGPRGDISPTIFEKSNRLELFTSSREKIVTSRTRLRVRLKFYRNIGRRMRNGTTCACPQQDDSSCSKAHSPCYTAFTVVVGVANQIVDFRFTPFVVVDGKTESIDALKESEWGEQMDFELPAKPQFFDIYAVNLGPVFGPNGKIVSWSETVWPVDAWTVHLGDNVPSSAMEPVFALENDFVGRYDTQSTLKLEYSMQCLDYFMGPSCDLLCTNDGMVQNSKLYGGINRLSNQETRQPIGTICESTLEPKRFYECIYVDNRRFQVQQCRLCEFGVMNDSFCVHTADQWRREGIDADAFKEQTLVVVLGLLFSLSLTLVLLLSCVLCWIICRQRRLVKVRRGDHFRGGPGTYRRSGFGAPYNVSENGFGSRSDWTKPKPPAAVQRGLQHNQQQTRGHGDSESPPTARPPKGAESSPSTSESDYRPSPFTPRREAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9L4</accession>
    <name>A0A914I9L4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914I9L4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7882.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7882.t1"/>
        <property type="gene ID" value="Gr19_v10_g7882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF16">
        <property type="entry name" value="ADENYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="246"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="381"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7882.t1"/>
        </source>
    </evidence>
    <sequence length="471" mass="52581" checksum="6D4FE792D18061A9" modified="2023-02-22" version="1">MRRPTTVAQKPPDAYVDVIINFILYVQKLWKKNDYKFVYACDETAVWLDPSGGTYVSEKGAKSVTVLNTSHEKARVTVILTARSDGVKLPPFVLLPKKRTVPEIVRRFKNKLVLSWCGRTWMDNELTTKYLEEVFGNFFFGNRLFIWDSSRIGPRFWPQNTALLLRFRNTRPKILDVRGQRAFFLKKLPRGSGGRPNGCATATGGNWSTKVHDKQTAGCSTARGSGDVEGQIPEILKEPEFQCIEKIKTIATTYMAASGLTGSSTDNSHVVAVVNFALALFGGPEELNENSSGNFNLHIGRDVGPVVVGVIGTEKPHYDIWGIWLMLPDEYGPGRDSGTNSGRVTDETKQILEREGFHSSAMAKSPSRQRTDDHLFAEAAEGRGAAARRRRSSAIPSMNQQSHGQWADGRRGEISDPIIIPPRPKDQNTPDVILDELMKLEQSYRELNLFEQEASFIVTTYCIPEGHSSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9M4</accession>
    <name>A0A914I9M4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g8177.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8177.t2"/>
        <property type="gene ID" value="Gr19_v10_g8177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF55">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TANC1/2-like winged helix" evidence="5">
        <location>
            <begin position="922"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1375"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1608"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8177.t2"/>
        </source>
    </evidence>
    <sequence length="1682" mass="182630" checksum="57545CE75E9D9607" modified="2023-02-22" version="1">MAAPSPSALLAAVARDELAPRRPSPSAAGTPFANSDGAVGGGPLSTLRRSLRQMNPFRSRLFRLPATPRLSRSKKVLARGEEFTGWNFERPSNASGDASHSLRPFCASFGSADVPPFAATQMRPQRRRLSQMPSPSMYLQYSQHPMAEPGEQCGCCTAGKELDDLDAFLTTMESIVRRGAPVGGSCRVVRHSNEQLEQEGLLSDSRGLARCTVAGNGGTALLPEAGARRVRPPIPSFDPPPFPPFANDCRECPQFLPSTCYAPDGEMFAARWQRPAKSPRPLSHFPCEQSPRALSRRRPVGLLLDDCGGNGNPSGDSENFVPSAQFAHRQPNSPSQSSAITLLNTASAVNLAARGARSASTVSGQQQKCVRSSSLFPQTQLQRRRSACSALSAGVGIVEETEEDGTTTAVMAEGTANYYGKDVIRLMEAAADGTRKADHLGPQPIGAHHLPPSTSPTAVSVPSLLPVPSPLFPLPGETVADVGEFVGREWLFRDLCHQLMTEQAQLILVHGTTGCGKSALIRHIAVHSPNFGEASAQGSSTDAQQQQHNTVDSGIAIGNGSSSAGSGGCNSSGSQLSLLNLPLHLPETLAPSTTANAATLSPARTQHEWLHALAINVVAVHFAQLHNSLSCSVPEFIRSICAQMCSSVQLKLTYGKMIRSDARLHQMATQERQSLDIEPYELFNELISRPLAKLVKEEECLRERAARGKRSSSKSSDYGSNGGAYAVGAEGRRRPFARIEPLLLVLIDSLDEAAFHRADGGECIGWLLRRVLSCDGACPPQLRFVCTSSSPGGVSQQQSLLSQLFGTLRDGVRSIQLDDWEGDERIARDLRLFVERRVHGSPALEKWVHAQFRRQSFFASPGPQPPNGPNVAEFGAQLVAHVNANFVGLKMALAMLAEGRFLSLDALPSELDGLYSLHFRHKFPTSAHFRSVSSILSLLLASLRPLNVEEMLSILNMAQQSPDLDQRELRERLSQLSPLVACEHSLTPASSVFLPVHPSLREWLLKEATSPDAEFVSDIRHSHIMIALSLVKGRPPPSLSSPQETFFELAHHLLKANPHKYMDSDLAERLGMPLGRDCQVKWLKMFGGDLAKALLCRRNVFYPNSKVSRLLLLAGADPNASEWPDGTEEPLLCSFARAGNLEMVQLLLQFGANPNAGHPPPLIVAVERGHEAVIRVLCAHPGTDLFVRDANGHGVLYHAAAHDSIGTVALFVDALDDAGGKSAGMPERSMDEERRVGTGLIGARLITRCLIIDQMPSIYSDELHSQRTRQRFGNEQNNQPTTNHRNYVGDRTQTIREAFEVAAERGSARVCRFLLDNTDTVLDTSRGMCIACANGRSEVVQFLLSRGATLSPEQTWNGKSALICAVESGSWDLVDGLSPLMVAARHGHVGLVDLLINRGAKLDMADAHGRTAAMHAIEARHSSTVALLLERGCALFARDTHGNTMLHLLGRHPNKCLIYRLLEDGLSLEDKNKEDLRPIEVAIRAGQLVAADTFLRRGARIRSLTWQIALSAHPPLVLVLLRKLLDDAQILLRRKRTAEAQHRLCYALQKCDELLEKANSGGAEAVRRMGPQLRWVKVQTLFSMATLKRRCNDLCEAIALASGPLRSPSGCSSGDECGGAGGEGPERRAEDEQRFELHLLRAKCHFDARDLERARVDAQLATCMRPGDSEAQNLLAVLSTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAH0</accession>
    <name>A0A914IAH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8792.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8792.t1"/>
        <property type="gene ID" value="Gr19_v10_g8792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="535"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8792.t1"/>
        </source>
    </evidence>
    <sequence length="887" mass="98613" checksum="069F3BB167F11C48" modified="2023-02-22" version="1">MFVYDSSGITAALNPATDEDWRLIASAVSQNGRRLRSGAECQAKAAKDGLLLTTERGPSPSSSSGRVPMPNQRKTNSTPVNPDNNGRRHGLFLSNFAHDDYYNEFFAKQECPVTELDPDDSMMRFCYGSRREGTEFGPLKQMRRPKRMLVPVVEHLKPDSSSSQSDGHCKDAFGDKRALFEGKAAVSALSHPPTSNPCTNKCFVPPVWRKSSRAMDEAKNMALLFFVDHLMQKGGQRTIHDLSCQFGARGFTDEMRQAVGTCQEGLCEFLGQYPSLFTIRDGDQVLLKGFGEGDEGRTHLSHIPPSGRQRDYVLEAVQFFVAKLEKFGPEMQVKSLLGHRSQAAPEVRLVSGRHLKEFADFLAAQTDHFTVESDRVRLKNMPEPQEADANQFVDEEGRPLVGHRAKLAAVDFMRGVLEQNEDVPIPLDAFYRRFCDRFPHNIRQEVATNPKELLLFLKLNRHVFFIRSNKVQLVRNRPGDEHGSESGRSTAEDGGSSDRSATSPAENDGFVPRASVEGLPASTLFPLNRDNVHRVQIAQTLKQAQEAVRCLHLDLDSALCPFLAVDFKLVSLGSVQPEQFVALVVVASPVRLVVFDLAHAESVLSESGLRTLLENDRLLKVLHDVQRIATLLASRWDIRIGRLFDTQIAHSVIQHDKFSKPLSDLRAISFVNLQRVYFPQSLVMSDVPARKLSQTLNWADRPMSTELLLAACEECHCLASGLFRLLDAQLPHALRPLFAKLCSEASVTTVVANGTAWNERNGRHRETAHATPPPERKVMPLLELPLNGLYRPPATRRRSSQNQPQLITRPFGQPPINGVCGGFGSSPIRKDSAPPATPHRSATWPTPPRAETREACTQTLSTGEIAVLKVYYDEEGTASNNGTKREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICQ7</accession>
    <name>A0A914ICQ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICQ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8998.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8998.t1"/>
        <property type="gene ID" value="Gr19_v10_g8998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8998.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="9317" checksum="B8348357EA5385D7" modified="2023-02-22" version="1">MLGADGAGGAENAVAGEADAVGEADEAVGEADEAVGEADETVGEADEAVGEADEAVGEADGAVGEVDGPVGEADEAVGEADAVGEAWSQLGGGARMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDV5</accession>
    <name>A0A914IDV5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDV5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9938.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9938.t1"/>
        <property type="gene ID" value="Gr19_v10_g9938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9938.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13426" checksum="271B88E98A13FCC0" modified="2023-02-22" version="1">MNINNTNSADINSLSLFLREFVVQEAGGGRRKRTNSSRRINPNQPVPFFPCTLSHRFGCCHSLPALLRGDNDNSSSIFEQFIVSYFTPNSSLFRAHLPAKRGAIIAAGAVSNVWCEGCVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEU0</accession>
    <name>A0A914IEU0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEU0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9574.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9574.t1"/>
        <property type="gene ID" value="Gr19_v10_g9574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9574.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21595" checksum="C30573F00E2551BE" modified="2023-02-22" version="1">MCGESFIHATFVYHRQKCSDGLPRFGCPARKDFYHQNGLWIGLKALETSAFKNKTKEQLVEMRNAAVRELAAVLSEEPGPKGVYIKCLPDKLSIFGLFELREELAIDMSGQRKMDADGTPASSMESLEQLDEMPGTSAASEDPWQRHAPKGWEQKPPSEWTKTEREMFNKKFLEKSFSKKPQSSSQPNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF07</accession>
    <name>A0A914IF07_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IF07"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9307.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9307.t1"/>
        <property type="gene ID" value="Gr19_v10_g9307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9307.t1"/>
        </source>
    </evidence>
    <sequence length="485" mass="55039" checksum="F8E14934C70C4327" modified="2023-02-22" version="1">MSDRLVKRKPDCASEEEVYGAEEETPPKNVAKHREQLQQFRFEEISSCTSATGFSQSDLLCPSNAVCGSTTVFADAGTAEYALDVQGYMAQHHTFISSAYAHPLKYYQLIDNGINQSRESVGDQFHSAEQLLAFNRERVRCLHRNFPITIGTAKHESAFFEEMGTTGYVNIRTVLSRCDDSTVKVRITKLYRPNESKEFEMSKAELSARKSAIVLAFNIEPLAYKIFYFQQSSLILRFFQRPLVDYQLEIECKYRPSGSRTQYYLIGSSIQLNGQNYINIPIYETEMLAFCEEDRIGLAIHNAEHERTTYIELTKELLLENDAFNINISNKTVQPILQGRNDPVLSSRTIVSSSRIPSDPSSSTTGQTESSTIATTHDKAITSSQVGKTESEVDEMESKQQSENNESVSLIVCAICRDRQREIVFLPCRHCCACPECSKQQWINHCRGLEPFEEMRLLLAELDRQQKMNSPTSSSVSFDLELDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFL9</accession>
    <name>A0A914IFL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9430.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9430.t1"/>
        <property type="gene ID" value="Gr19_v10_g9430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9430.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14811" checksum="3A82EBDA41CFA11C" modified="2023-02-22" version="1">MEGPPAIQASNNPLKKPIGGWRKATKSFQFLAMFVLPIHGVMTHLTFISTILRLPENNNWHTVLNTHGPGQYIYNRHVGVWGRLFDPLPENELTRYSKASFSGVFVVVESDSYLGVKTQHFCHAYLCALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFR0</accession>
    <name>A0A914IFR0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFR0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9485.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9485.t1"/>
        <property type="gene ID" value="Gr19_v10_g9485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9485.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="13948" checksum="B36C50F13554214F" modified="2023-02-22" version="1">MASHSAGGRGPPAAPSPPAEWLAVLLGAGVHQPPPSLQRSGWPFCWGQGGVAGRSAGGRGPPAAPSPPVEWLTILLGAGVCQPRLNSVFRFLGCTLRLSSRTGFKFKTTHAHPHEAIQVSVRFAAIDQHTQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPD8</accession>
    <name>A0A914GPD8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPD8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10198.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10198.t2"/>
        <property type="gene ID" value="Gr19_v10_g10198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="16"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10198.t2"/>
        </source>
    </evidence>
    <sequence length="219" mass="25081" checksum="19E55175995C0E5C" modified="2023-02-22" version="1">MFEEVETFAELKLRLKVKQMELNITRLELKNMHLENENAKATARTAYRFGAQAIDAIEFCAAADRPKGMSKWTHRTVRAEFTMSQKTGISYFEVTIVRLQNMYESLIGVGMATKAMPLDTWIGEHRENYAYYDSGYIYGHSINYICGFPRYETGDVIGCGVNWATQEIIYTKNGERLDTANLYVLTTTDLYPAVTMYNPGDIVEANFGPIFQYNYISDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPV0</accession>
    <name>A0A914GPV0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GPV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10322.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10322.t1"/>
        <property type="gene ID" value="Gr19_v10_g10322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000011">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF161">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="59"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10322.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24102" checksum="0A4D7192BF925C43" modified="2023-02-22" version="1">MLPKPLVPVSAKQANLLGVFGELTSRWHYAIVHFTSIISPADRSFVRSPFWSEKQMPDQKEKEFMHNAVEEGIRGVQCGDGGPFGAVIVKNGEIIAQGHNMVLTSNDPTAHAEIVALRRASQALDTFDLSGCSLYTSCYPCPMCMGAVLWARIANVYYAAAPTDAASVGFDDQNFHEFVRDPKCFEQMMALEHLPVEGHMIVFEKWEQREEKRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQE3</accession>
    <name>A0A914GQE3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQE3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10214.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10214.t1"/>
        <property type="gene ID" value="Gr19_v10_g10214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036989050" evidence="3">
        <location>
            <begin position="21"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10214.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41691" checksum="AE3777B162777CA6" modified="2023-02-22" version="1">MHFSKFAFFVISAILVPILCQNDTNEHLLVNLFGQELAASNDGTGELRDFLSELDEQNLAIQEVFLPPPAVHHLHEKYYLKKFNSDEKQNLPFQRKSSSIKFKKLFRSISANVSSKTMKEAAAAKNECPQKHLSLIDEAKLLRENWQIVEQKDPPFACIFTLLRTSLNDIKAAVSVGSVTETFKNVVIDATFLLADRMQIGRDQIIPENKKRTGGLKLLTEFAKLWAQMKFNGQFFFNYGEEKEKKGQNGREERQRSRRKGAREMLRLILAAVGDGNIAALNIVPKKGGDGSLRRRRKKRDGLILPILGVVGIILLMLFACLASRICCPPTDGTGSTKNGGGGSTKSKSGSTSGDSYNFEYSNNLGLHFFFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQM0</accession>
    <name>A0A914GQM0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQM0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1028.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1028.t1"/>
        <property type="gene ID" value="Gr19_v10_g1028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1028.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31720" checksum="5657119D43A079E5" modified="2023-02-22" version="1">MPASSRFKTLYRNCLRKREDFHDFLQYNRIERCRMQTEKMRRELEQRQSANAGCSSGQPRLESPDTEQMHAMAMMQQQNSNKLNSSDAGQGNASSSLDTAHLEDTFLLGGAAGSASSAFENGSGTTVRPNQPILDISDDESVAEGGTKRVKSRQLEKNEQDSAVDLNNETFNTSEKRASTLLNLTHPVLSDGGIEGMAVRGESDRTQTLEDGPTLMNTSHPVPARGTTGDEPPQQQQQQVQDGQNEGTNAPGAAAVADKSSLLFDPSLSFIRRVSMDQHHRFAAYEIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTK5</accession>
    <name>A0A914GTK5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTK5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10632.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10632.t1"/>
        <property type="gene ID" value="Gr19_v10_g10632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10632.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22233" checksum="47A7C033309EB10E" modified="2023-02-22" version="1">MEESAERRALVVEDGAGHPLSLFSVPDCYCADIDSVLIPHGLIHDRIRQLATEIHREIGDRPLVLICLLKGAYRFFAVLAEWLAELRLTCNSGLSSIDGSLGGANVLLVDDIFDTGLTMSRVVESLNALTEPGGRIWTAVLLTKRTPRRRKDALREDFVAFSIPDRFVVGFGMDYNQRFRDLSHICVISQSGIAKYKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV39</accession>
    <name>A0A914GV39_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptide chain release factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GV39"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11618.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11618.t2"/>
        <property type="gene ID" value="Gr19_v10_g11618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide chain release factor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11618.t2"/>
        </source>
    </evidence>
    <sequence length="591" mass="65032" checksum="029D58C756EE6D66" modified="2023-02-22" version="1">MRFENGVHRVQRVPVTEANGRMHTSTVSLAVLPEPEKIAHQRLAAMLLKQQVDEATRRYASNRTLRVGTMERAEKIRTYNYKGNRMTDHRLKLTRHGVEQFLAGGEQLEKIGSHLYVGDQQRLELVAMSDTRLCAQKVLLATDESSNNATQSWPFIMGHEGEMCSGRESRLMNGRTYSPVSVGSNCSDKASARSVVAEEPIQIKTTMSAARQQTVQNVSLVFLTLQQTVYPIMVREAHKMSRDKGQPSFLASAVVLNTELSKLMLSCLILTISYGSFTRFCSEIASAFFKNKRETMKVCVPALIYVVQNNLYFFALKRVEATLFSISYQLRILTTALLSMLLLHRVFSRRQWGALCISLLGVCLVQFASSSSSSHGGSAGASSSAAAHDEQFVGLLTVVVMCWTSAFAGVYLEGVLKQSACDIWTQNIRLSVITLPFALMTVANDSVTIQKHGFFAGWNWLLWVIVISAAASGILVAVVMKYADNIKKSYCQSVALGGTALLSIAIGDSHFSVPLLVGVALVIASVFLYTLNPPPKVKSATPEVPPRDDDDLMLLDDDEYDDDESGDDDETELKLDEKDNGAGHNGECGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVR4</accession>
    <name>A0A914GVR4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVR4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1085.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1085.t1"/>
        <property type="gene ID" value="Gr19_v10_g1085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1085.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31256" checksum="6B6F9D2117493298" modified="2023-02-22" version="1">MERPPSLKKRISRSLIRIPSNIRQSLSSSSNSTRNISFSGNSPRQTPAHSPRQNGTKPINNQFLNQYETEIVLRTLKRALKEVDFGNEIVIRLLNDKRSLFKSLLARCAAQAHEIEVFDGQSLAQFCPRAVQVGDGVTRFFERVAIEFEQPTNCAELEQTLSEMCRANGQLHYRMKVWFQAENWLCVKHSVVDTVMMANSNLKRRGPRSAGDLSSLTPRLKKHSLNGETFDRYGRHECIEVVWMKLMQAVITWMKQGFLEAALCAKEEQDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWF5</accession>
    <name>A0A914GWF5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11028.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11028.t1"/>
        <property type="gene ID" value="Gr19_v10_g11028"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6790.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6790.t1"/>
        <property type="gene ID" value="Gr19_v10_g6790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11028.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6790.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36084" checksum="8F0018652E0733E0" modified="2023-02-22" version="1">MFNTQVFESKNAIPAGHQQNVGRRMYRNDSAPISFVSAKTEVYDVKDAVKDEPPPPAAAEEEAPSNSNDGPNLALNDLEWVANSQKSGVLLQMMKNMGFTEGKGLGKTGQGIVEPILSKPNPGKKAFGASHTGYDKDSQNCFRAAAGQKWIGGNGQVREAESCGTERQRQRVGEGRPGPAQKNQMPCQHNVKGTLKSAGFTEHSAEAIWQAMAVLANHKIMSLDTGFELVKRRVGSSRRMEMPFHTASAPPAAVQQSKNGWRPDLKTSRTQKPGAGLNRPKTFWSSSTFRHHSPNTTIHPFQTVAAPPAAVQQPKNETKMSTDQILALFGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWH0</accession>
    <name>A0A914GWH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11829.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11829.t2"/>
        <property type="gene ID" value="Gr19_v10_g11829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11829.t2"/>
        </source>
    </evidence>
    <sequence length="428" mass="49320" checksum="C104958831A28F3D" modified="2023-02-22" version="1">MAFKDFCKKRRAPRLLNSPTHSFRSPNWGRGWLLSVGRLLNAHKSALNYSPICADDDQPQPANRQRITRIMRRLHVQIFVDINWILGKQFTEEQMVLDRRTASIRRPGLPKSRVPPVVAQRHTIAEPNFGKKSRNWLPTAAKQHHQFVTKESNSALRERETGSWRHIQLYSTNVPSSFHSRSFEECPRVTRVQHATAWRRARSEKFVEEEEEEEEEAETDNQSARLQFEGVRYCPPPPPRRPRHAHLQRFFRSADAASASSTTTTATNGSITGCGGCSSTVSGNSSSTTMPTMEEGRRMAACWRARKPTNRLYRSVDDDYGGRDQRDRRRGVPILNDHRRLLPDVPTKMPKKSQGQFPPASFVPRLSPYTMPPPYSYRIPSVQRADPSPLARFNSLNRAKPLRRDFSVDRRTESLFRHFVRPDPFEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY81</accession>
    <name>A0A914GY81_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY81"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12434.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12434.t1"/>
        <property type="gene ID" value="Gr19_v10_g12434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12434.t1"/>
        </source>
    </evidence>
    <sequence length="697" mass="76907" checksum="15F5B95B3B1FC3A6" modified="2023-02-22" version="1">MGRHSANLLLLCIKRQRRQENENITVNAQMGTTPQPQRAIVHKGWLQQKIYRNGTLLRKKKIFYENELFVVLSVHSAANGPTPRLEWYAEQSAIFERQPLKSQDLTECHCVNVAIGEERCLAIGFVDGSAPVLELLAPSIEERVQWVDILRATLRRLNFLNSENGGDQPEEEGSVPTLWPRPTNEYVVLAGRSCENDDDKLSTSPPQQSPLSRTTANANCGGGKGPSPPRMPLSPIPLDYSALATTPLSLGRTPCLNDTMPLLRQQTPPQFDVDVENEHQISSLPCEEQCPSSSVSDEKRADEPISEDKKSLENGCGDERLQAVMPPPLPPRTPRPSAQSSKANPYSTVPRIPKSPIPLSPSQDLSHYEVLNAFPSPQLRSQYDHLCANDGQLQHSHCSLLPCGETSGINAPSSSSSCKMPSVEQSTETAPTSFLQSPVSAHYDVLCAPSSQYDVLNASPSILMPHNQHNATTDRLFRDALSRSRRLFFSFTLLTEHVALVELFDKVWVAGWTSELYELTGIMPGAQIPLLLRSNPTMMVFTLVKPENSKLGLGIKFHRGTKFLIRQPFDCLTIDSVALKSPAHRANLPATVPAYLHQPTPHSLNKSQQKSLPSSPHALPSGSDRAVITHLDGVPLNPFGPRDQLLRRLDAITAGNSFNVTLHSADFCSRLARQLKHQLGGSKLRHFVHGEPPMRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYA3</accession>
    <name>A0A914GYA3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g11500.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11500.t1"/>
        <property type="gene ID" value="Gr19_v10_g11500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11500.t1"/>
        </source>
    </evidence>
    <sequence length="1645" mass="184003" checksum="943B2D1FBE926BB0" modified="2023-02-22" version="1">MIADLDNPRTQLALFERRRSWRDTVGSDAVGSNAVGPETQLARHSWLRRSWPGAVGSDAVGSDAVGETQLAQTQLAQTQLAQTQLAPRRSWPDAVGSDAVGQTQLAQTQLAPRRSWPDAVGQTQLAQTQLARRSWLRRSWLRRSWPRDAVGQTQLAQDAVGPRRSWPDAVGQTQLAQTQLAQTQLAQTQLAQTQLARRSWLRRSWLRRSWLRRSWPDAVGSDAVGPETQLARRSWLRRSWPDAVGSDAVGQTQLARRSWPDAVGSDAVGPETQLARRSWLRRSWPDAVGSDAVGQTQLAQTQLARRSWPGAVGSDAVGSDAVGETQLAQTQLAQTQLAQTQLAPRRSWPDAVGSDAVGQTQLAQTQLARRRRSWPDAVGPTQLARRSWLRRSWPRDAVGQTQLARRSWLRRSWPDAVGDAVGPVGSDAVGQTQLARRSRPDAVGQTQLARRSGQTQLARTQLARRSWLRTQLAQTQLARRSWLDAVGPETQLARRSWLRTQLAPRRSWPDAVGQTQLARRSWPDAVGQTQLAQTLARRSWLRRSWLRRSWPDAVGSDAVGQTQLAQTQLAQTQLAPRSWHAVGQRSWLRRSWPDAVQTQLAQTQLAPRRSWRRSWPDAVGPDAVGRRSWPDAVGSDAVGSDAVGRRWPRRSWLRRSWPRDAVGQTQLAQTQLARRSWPDAVGDAVGQTQLARRSWLRRSWPRRSWQTQLAQTQLVPDAVGAELAQTQLAQTQLARRSWLRRSWPRRSWPVTQLAQTQLAQTQLAQTQLARRSWLRRSWPRDAVGQTQLAQTQLARRSWLRRSWPDAVGQTQLARRSWLRRSWPRDAVGQTQLAQTQLARRSWPQTQLARRSWLRRSWPDAVGQAQLAQTQLAQTQLARRSWPRRSWPRRSWLRRSWPRRNAVGSDAVGQTQLAQTQLARRSWPDAVGQTQLLRRSWPETLGDELAQTQLARRSWLRRIADAVGQTQLAQTQLLRRSWPRDAVGQTQLAQDAVGPETQLARRSWPDAVLDAVGKTQLAQTQLATRRSWPGPQLDQTQLARDAVLAPRRSWPDAVGSDAVGLRDAVGRDAVWPDAVGSDAVGPETQVGQNASGQTQLAQTQVWLRRSSAQTGSWPQDAVGSERTVGLRRTSWLRRSWLRRSWPDAVGSDAVGPGRQLAKTQLIPDAVGSDAVGLRRPLAQTQLAQTQLARRSWLRRSWPRDAVGQTQLAQTQLAPDAVGPETQLARRSWLRRSSASDAVGSEQLRPRRSWARRSWLKRQLAQTQWAQTAVGSEAVGPDAVAVGQDAVGQTPLLRRSWPRDAVGQTQLAQTQLARRSWLRRSWPDAVGSDAVGQTQLAGAVGSDAVGSDAVGATQLAQTQLAQTQLAQTQLAPETQLARTQLAQTQLARRSWLRRSWPDAVGQTQLARRSWLRRSWPRDAVGQTQLAQDAVGPETQLARRSWPDAVGSDAVGSDAVGSDAVGSDAVARRSWLRRSWLRRSWLRRSWPDAVGSDAVGPETQLARRSWLRRSWPDAVGSDAVGQTQLARRSWPDAVGSDAVGPETQLARRSWLRTQLAPRRSWPDAVGQTQLAQTQLAQTQLAQTQLAQTQLAQTQLAQTQLARRSWLRRSWPDAVGSDAVGQTQLTRFGRSWPDAVDPLRSQWQTPKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ31</accession>
    <name>A0A914GZ31_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZ31"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12509.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12509.t1"/>
        <property type="gene ID" value="Gr19_v10_g12509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12509.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7750" checksum="DDFC778F1E40C16F" modified="2023-02-22" version="1">MIIPVRCFTCGKVIGNRWDAYLQSLQAGNTEGDALDQLGLRRYCCRRMLLSHVDLIEKLLNYHPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZC4</accession>
    <name>A0A914GZC4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZC4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1219.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1219.t1"/>
        <property type="gene ID" value="Gr19_v10_g1219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1219.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9844" checksum="FBC380CEBFC911F0" modified="2023-02-22" version="1">MAPEAKLATERRTYAGYNYVAGEHSFNLSTKPWSQSNYRFLRVSHISSTPRYFHGQISNVRHYNSYRPPAFTPRLSTYWKSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H031</accession>
    <name>A0A914H031_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H031"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12380.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12380.t1"/>
        <property type="gene ID" value="Gr19_v10_g12380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12380.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="9876" checksum="BA6F78D02940F4CA" modified="2023-02-22" version="1">MDLKLSVYHYKHCINSNAGDLGDLDLSPLDENGRTGLIGGPRSGGVAGGERLPGPNQQILSKPPLEGFPFRANPTPAHPTDPFTPSTVSVRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H045</accession>
    <name>A0A914H045_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H045"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12957.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12957.t2"/>
        <property type="gene ID" value="Gr19_v10_g12957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12957.t2"/>
        </source>
    </evidence>
    <sequence length="595" mass="67555" checksum="F7F5D350714BE99D" modified="2023-02-22" version="1">MQFMGTIADTLTEAGHEVHFMRLIPNNFTISWPKEVHKAQKIYDFRQMFAENSINVQHLSLLKDPFDGNSFATFLWQSNVWISFMNFAANLCQELTWNDELIRRLEAEQFDVAIAEMYDFCPFAMFHRIGAKTKLAAIAAPLYQVTAKHFGIPAFASYAKPASSTCCLHECLRTYSSRNHIEEPIVRHAFGNDFPKMKEIARNISLIFVNSNQFFEFPRPISNKVINVGGMIEMAQKQLDPKVSRLLDKAKTGAVFVSFGSYTDTQKMPNQMKMALLHTFAQFSDYEFIWKLELSERDAKFFAKHKNVHPVTWTDQKTILLHPKTRAFVSHCGLNSLTESVRAGVPILAIPLFGDQKYNAILAEHKGVGIKLDVKALQTVGAEELFFASLGKVLNDPSYRSNAQMVKRKFELMPFGPKETLIRWVEFAAEFAELNELNLPWEDELGTLAYYSVDVLLFSAVVVGVFVCILPLTETRKKKFYQKKPNRECGGNNFYDEKLADKLRDLPQNERASYILMQKLYPTTFKNYFLRPFNEPKLSTVVGEMGIYGTLIGNKLDGSVQHNVQSGHLLRTKLAGVNEGGISVGTGVGDSPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H065</accession>
    <name>A0A914H065_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H065"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12827.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12827.t1"/>
        <property type="gene ID" value="Gr19_v10_g12827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036700207" evidence="2">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12827.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18191" checksum="DFE57504EDAF9BCF" modified="2023-02-22" version="1">MAPYQGRVVVLRRQIPHFVLFLLLLFAAAPSSDGLSCYQGLANLSVPLSGSATQCPIVALSCIKAVDYNSGQVTRSCQATNCTVQTTQSQVANNQQQQQQQQQQQQQQQQQQQPQQAMSTVAVCVNNTASTFCCCYGDGCNSALSPGAMSSLLRYSIPIALLLIVGGILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1X7</accession>
    <name>A0A914H1X7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1X7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13248.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13248.t1"/>
        <property type="gene ID" value="Gr19_v10_g13248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037225927" evidence="2">
        <location>
            <begin position="23"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13248.t1"/>
        </source>
    </evidence>
    <sequence length="828" mass="93321" checksum="82F0D360027124D6" modified="2023-02-22" version="1">MALLPHFLVVSVLAILIINSNARTVIVADGTFSDENGSFTAPLSLSHSYEQNVPSLMALMREFSNNLETKQRAKQPTEEGTSKILSRATEVPKVIGVEEDGAFNEAKRDEFLKKAHIVPIGDDHALGMLQHWADQAFSNLFAVVANQKLREFEKPIHDEFGECCKKAKTVPMHAKCVSDLFNGKFDGAMFYEQAKKKSNRFDRYRMKKRGEFRREIRNENKWVGSFQTVVPSTSGRSNEAAEEAKLSRGFPQLRSYNANRRERRQTNIVKKNYYELLTPSEGRLSPMGQIAKKMMKKVLKVKGKQEKDIIPWQNIVQKISTSVKRRKEIKRKLEEDSVESLDQLTYRGLKRQGAVEDNLNDVIDDPKKLHNFLELNGKGKGRAPIDRFIKLLREGLKLGYSFVGKNMSDFDNKTLKMISPRFLSVMPEESHKNETIDFLSPSLFSLHNSGTGLENLTSLPNIMQNVAGPFGFSAKDQQLWMDFIMEASGVVENAEKVEAEFNETVGEDALKTVWEKHYDKKRYEREIRTKEGTPLYFTKQNISDGFGQKEVRKVEMFEELQNTMGKEQIRDMNRTGFALLSKKQLDLMYGPNSEFHDEKAFKRFLMMNKSTILQHIEQDIHTLAQIKSFKITRKSPPAGRQLHSRSKRAVVLSPITFSPFVLTFLNANPIILSPILFSPLILAPAVLGPVILSPWAFVPVVLSPRLLSPLVLSPPIFSPVILSPLALHPVILSPGVFVPFVLSPVLLAPFILSPQVFTPFILSPLALSPFIFNPAVGSPIILSPYVLTPIIYSPMAISALILSPYALSPVIQSPLIAYAVILSPSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H411</accession>
    <name>A0A914H411_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RBR-type E3 ubiquitin transferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H411"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13437.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13437.t1"/>
        <property type="gene ID" value="Gr19_v10_g13437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="467"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="471"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13437.t1"/>
        </source>
    </evidence>
    <sequence length="874" mass="97980" checksum="DB3A3BA3E7F92962" modified="2023-02-22" version="1">MDREHELTKVERKEQKKQLMTNPKVQSFLQIANELCGVGKEAAFVVSMAHSGAKFLRSLAFTKEHLKLLREPADDLELSFRLYLLTLDKSGKNLLRKICHNSGFKTHRIVEIAELASELAAGHSTNLFYTERRRVDQDTRTFKSIVLHDANKVGFLTISALSYAFCQAFNDNICNFYDLNGDGNGVFFSLAHGRSVNLPEHSFACKSTLWAKENKNQIVAYSFSQNEMDAEVLNAFFVCRLPCSLIHEYPVEQLNQLKINIGPMVAEKLLSNDFVKKYCGGDLAIFRGYNPATGVLSLTCSARSAFKFCQLADGTVNSIFEMLDTMDNLRWLDEQCGALVSFGPGFQVSRIIANPSEEVKDTIVVTFGESFGEFEPAVLQLTELSENFCGYRSCNPLLFTKSRRFFITLLTPSIVKELKPILESAFTNTSRESTVTVETKSGNIFEYFAGYNAKNSVGCFLDDSSYPTECCAICFAPIVGKYIRLSLCGHVYCDDCFIGLLKNATQFPVSCQSGCLYQILFEDIALVLSRNFPDVDEIQQFLTPTADCHSLMPLTKEGAISAVGTSMICIGCEMKRCTLCGEAVHQHITCQERQEQKFGIEYPDLTAWKNELPTHRRLCPNVHCKMLIEKGPGCNHMYCNQCGVHFCWLCINFQAGTTDEVYRHLRELHGSIGEPGFIDDEVNQHFGLLVQQIGYERAAVMMNVEVAPDGLMMTDPYYAHALMVIEAYTQKEEQEENEEEGGNEDPLLKYGDNLEAMYRQYKKDCEESRQALIIVILLPFCAAHHSPDDSCPLPFPPVFCSAPLGPQSLSPNVLSACCLPIDPKIISRFFDIRFGFDTCIYGIPPLSVRAAIWLTSFESKMTEKGQSMAFPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H424</accession>
    <name>A0A914H424_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H424"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g138.t1">
        <property type="protein sequence ID" value="Gr19_v10_g138.t1"/>
        <property type="gene ID" value="Gr19_v10_g138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037838658" evidence="2">
        <location>
            <begin position="18"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g138.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29406" checksum="BB09935F02BCD9BA" modified="2023-02-22" version="1">MMAFCLLFLLPLFRCFAQSPPSPQLPQQQRDNLISNVGPGDVLMPNLYRWMEQNAHICQNLASPAVFLTEFEAEQFKCLALCGDWDSAKACAKESDKFNQPPNCLPVPDLCLQNFQQEYFSLQFTREVFQTSTNKATATSSTTTVLSSTATEMPTQIGGTSTVAFARFHGMPRSNELQLVDSDLMVVDGEAGGDASSLAGTTTAFPVPASPVPASLLPVPDFPTPSPLLLCPAADVDVVSCAWWKRVGECARNSRFMQRVCRRACGFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H484</accession>
    <name>A0A914H484_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Extracellular space</location>
            <location evidence="1 8">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H484"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13495.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13495.t1"/>
        <property type="gene ID" value="Gr19_v10_g13495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19343">
        <property type="entry name" value="Wnt_Wnt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF102">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13495.t1"/>
        </source>
    </evidence>
    <sequence length="608" mass="66886" checksum="A52040DC48F694BE" modified="2023-02-22" version="1">MALFDGWQIVGLKRLWLFTFLLVALTAFFPRSSVSIKWLALHRVQPPWNESGNCPRTKEERKVHGLINYQARICARLPELMPHIISAATLTVDLCQWTVADRRWNCSSVLRAPHLTNDLTSGTKEQAFVHALSSAAVTHQIAKACSSGQIGNCPCGFGDSVTTTSISSSHPSGPPAGGNNNLLQPNLTELSYKWKGCSDNVIHGRRISREWSDAKWRPNPVDALTKIATKNRWNILEEDGGEDVRLMKLKRQAMDGKRSGQKARMNEFNNEIGRQIAEQSLYKKCKCHGVSSSCDVKTCWYTLPPFEQIAETLRQRYDTARPMLSMNNSKRRWKSVEDSRGWQNLVYLRSSSNYCEQNVSLGSVGTRSRECNISSFGTDSCESLCCGRGFFVSQMRVEENCHGHSSGFTASPSSISLPKALSFSFGFPPASPPAPMCSSCAAPPPSCCPCASAPSPCGRGCAAAARLHHFSSLRSLFWRRKRGTELEAPTRTFNSNESPCPRGDWQRHMQKAIIPTDPSVSVHAVHSSLSQLYDDPMASDEHGHSNTFLLMVTCANATAFGQNQSDGQKGTIPSGVSLISSGRNFCNVRVREAGGDQSLWCQAVAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4A3</accession>
    <name>A0A914H4A3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4A3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13121.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13121.t1"/>
        <property type="gene ID" value="Gr19_v10_g13121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039149">
        <property type="entry name" value="ZNF800"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="831"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13121.t1"/>
        </source>
    </evidence>
    <sequence length="953" mass="107689" checksum="FEA7F725AFD5E7CD" modified="2023-02-22" version="1">MSLNNIKDPAAQAPNFPASNCDDGAESVVRYYQGGTDEVKNLLKNECSVIYECSYCRSLFRSIINFVAHKRTNCRTLLSSVRAEQAELVRDSQKSNQKGHGEKDSDSVNNGPKKSARNTRNLNLRRFNPTTNLVRHIRAVNVHLERTNTDVEVQTLPRTMRKPVETSIVDGKQVIGQLPTELSMKSLPENRVALVMPRECSVRCGEMQLRRRRGTQMKARPDEGSVCELTSEEIEIIERIPSAMPVDFTTNHCEDQRCVSRGLLPFASLSSLAHHLAVQHQMDYSEEGLVKQSENKAFIKCFLCDVPPFYCLEDLQKHFNAAHSIVRQHHNRFRMEHTNAENNAKRKCLSQSNFRSLSPISQPKDEEDGEEVNEEAGDEEEMEESLELKKSKRKPFRRPILFTPMTKEEEKQQHFEAALALRDWVRKVGKVKPHEKILEEDEADEVPPLRNVVTDVEGRCFFDEEEARKIDRLLNSRTDATDKLVEEESSEDASEQKTFGTNDDEDDKNDGREGLDEMDGSHKNRERRSRKPNRKFLEGPVEEPRQLTENSKISRPAKPRTPTVPLDGSANIPSTSAAVYSKKSTPKTAGKTSLKRKSARRNVFKNRKRPKVSDILTKPKESSETMTNYSSIDGINAEKVERSRTPTPMSSSAIPMKDFVLPAQILFPGKEAVQTNGAEPPQLVSEMDSGAPTEEPQSGPKEGSAEQTERRDSVAPPQLTKECLPTMVTGRYREDLIFYTPKARAKIREEELRRLVSSSSGSSRRKQIFSSSELTESDGISLIGESSRSKDQPKTETNEKPSSPPPKPKDLGQPLKPLFNTNSVDDGFWQCGECGEVLKNIRDGRRHMVSHIRVMRMRCSLCDAGAFFCSDMRVHLMYRHCDKLSLAPDDFILPGVPCMSREKADLLTQLVDPYHPGRVMYTTGKIVSWSNPKAYFPDPKSERNILGPALPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4F5</accession>
    <name>A0A914H4F5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H4F5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13550.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13550.t1"/>
        <property type="gene ID" value="Gr19_v10_g13550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="12">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="963"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="546"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="665"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13550.t1"/>
        </source>
    </evidence>
    <sequence length="1048" mass="119463" checksum="60B42F4A477B07D3" modified="2023-02-22" version="1">MVQFVGLKIAGVRSIGDTPQCINFLTPLTIIQGLNGTGKTTIIEALNYVTTGALPAGKMQTFIHNAQIANTSRVDALVQLDFRDIKGNKCTATKRMNASTSHTGKLSTKSDEFTLKIVDKFGNLKSISSKICDFNKEMLNLLGVPKAVLEHVLFCHQEEANWPLSEPKELKVRFDAIFEVTKYVKALDNIKKTIKELGVQIQLIDKELPHLENNTRARADLRLRYDETLTALKHNRKSIEQKLKEERETVDKELLIIRKQLEMAVKCNHEFDVIQGQINAQTRFLDGMPPLTYKDSREQLQQSIDELKRSASVREADELRASVVRQVQSIAFEMNQCKKLEEAYRTKQMQHESRLMMIENRESEYSTLLEQYARKYDVTAGPNFVEQLREKVQNIEEKRTYFVADTDGQQKQLAEHIEKLRFNMAQLNSNSTTKRQECAKLSQAIASAERELRSLGPTTQIVDKLTQDIVKWESQLKQLSDFSLLDDVWQSLQGLQTDLNTLRMDMMELASSGGDEGVVGKATALLEKAGDKLDLSMEHIGTLKRRVQLSNQLAEFKDRRAAASEKAIQVETIRESIGEKSEQIKQLEQLIATAGHELPEVERQLRAMERSKQELDASVHQQLRRMALEVDGINGALEKIAELGESNERDRLSMSATPTDFREMFEEQKLRLENLACRKSQLEKQLDGDEGKKHQLRTLEDQLRRMEMEEQLEKYKKQLEDAKENATIKGTENLMELRKKEQTVGQRAVEVNNRIQQKTGEQLQLKRKVEELRAQLEETRYANAQKLYVDKLVERNVTSASIGDLERYYKVVDNAIINFHQQKMEQINQILHELWIRVYQGNDIDTIKIKSQPVSGVEKKKSYDYSVVMTVDQVDIDMRDRCSAGQKVLASILIRIALADVFAGNCRILALDEPTTNLDEDKVENIGSMLKSLIQIRKPTTTGGAIGAQRIYEADDLDFEEDDGDELAGAAAERTRAAEEDTNDGDDGMEVNRSLQLIVITHDRRLVEHLHLACRPEYIYSLAKDENGVSHIKEHSQITTNADLDLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4L9</accession>
    <name>A0A914H4L9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4L9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13793.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13793.t1"/>
        <property type="gene ID" value="Gr19_v10_g13793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13793.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17185" checksum="FBA098C277EC4FDC" modified="2023-02-22" version="1">MRSLRSPRLILYFPFFSVLSTPHSLFLTLFSSFSDALSALSTPHSLFLTLFSSFSDALSALSTPHSLFLALFSSFSDALSALSTPHSLFLALFSSFSDALSALSTPHSLFLALFSSFSDALSALSTPHSLFLTLFSSFSDAQSAFPTPLNKMYVGRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4X8</accession>
    <name>A0A914H4X8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4X8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14199.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14199.t1"/>
        <property type="gene ID" value="Gr19_v10_g14199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14199.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11523" checksum="A89E6CAB4C8DA49B" modified="2023-02-22" version="1">MSRRESGRQDESTIAGLAGAQSTAGVHTQALGDSVRSRSRAASNGSSVVVCDTRSRWCSKHAQLLDRRRGVGCRLRKWIQFPAVAPKNLSQTPVVMVATVVGGDEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H676</accession>
    <name>A0A914H676_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H676"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14556.t3">
        <property type="protein sequence ID" value="Gr19_v10_g14556.t3"/>
        <property type="gene ID" value="Gr19_v10_g14556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036699387" evidence="1">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14556.t3"/>
        </source>
    </evidence>
    <sequence length="144" mass="16291" checksum="CB98821DAB04B388" modified="2023-02-22" version="1">MRVLPFHCLCIFALIIRQNSLSDHLQCFLCEGPCNCQGRQLSQKCVPNDRLHHPRCYSVKSVLTGQVLRKGCSADCESVEVSGWQKCQLCEGQMCNKNDDDDVSKTFLLNDCQMSQFFGALQTIHNNFRRESGLEGAATRDTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6S8</accession>
    <name>A0A914H6S8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6S8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14346.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14346.t1"/>
        <property type="gene ID" value="Gr19_v10_g14346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14346.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11463" checksum="BE07E8711EE8D0D2" modified="2023-02-22" version="1">MNPSEELRLLRARIAQLEREQTINLSTSSSAASADQFSLMQSDQKRLMGRLDGKKVRNEKKATLNDNETGTDSHSNEVLTNVLPISSSATIHRPQLQQTVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H792</accession>
    <name>A0A914H792_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H792"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14356.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14356.t1"/>
        <property type="gene ID" value="Gr19_v10_g14356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037804368" evidence="2">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14356.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29028" checksum="641D6E95436DBBED" modified="2023-02-22" version="1">MFFENFIFAFIKLLFLVKIGHVSSCEKTVFYDGCCICCGTSSLFGCPKPFEPPNCNIFDHDCVACNYIYNKTNECSERVQCSCYYCCDLQYAESCPDGCADCVKEGQGGCPENSASIGNSSSSILEGEAKAWEHFDMIDVDKNGRISLNEAIDHLETKLKNGTSNKNLAKNVPWFAKMDSNGNNQIEPGEFDRSLIKVNKSFFFKKFKQIFRTGPNGGGLCICLVKTEHCLKNVGSIRFMCRVTCFWFSIARTGWSHCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7K7</accession>
    <name>A0A914H7K7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 32 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7K7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14558.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14558.t1"/>
        <property type="gene ID" value="Gr19_v10_g14558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14558.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10303" checksum="1A76F426B91C7A78" modified="2023-02-22" version="1">MHIFIDLDSVEYFADEGRWSGTIRLPNASQENRIGTVELKSAPQILKEASMWYLNYKAHKSTYLQRSENRKCIEGFGQIKKDDQENCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H801</accession>
    <name>A0A914H801_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H801"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14074.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14074.t1"/>
        <property type="gene ID" value="Gr19_v10_g14074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037931585" evidence="1">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14074.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20649" checksum="4FE497C0D4F6E1D4" modified="2023-02-22" version="1">MFTKYPIILLFFITVLLCPLNVYGMDGASNSGDDNQKHVLFKGFVGVGETNRPAKQNGLFMSIFCGKNIVFDKIFTDQNGKFEVQIQSSAVNDLEECKNGINICFERKDPSGKCKNIIIQLDNVRIDGKSKKVPLVFAKVDSSDCLIFLQKEEDDAENNFQVDFETQFVKINGAEAHILKEHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8M1</accession>
    <name>A0A914H8M1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8M1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15058.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15058.t1"/>
        <property type="gene ID" value="Gr19_v10_g15058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15058.t1"/>
        </source>
    </evidence>
    <sequence length="768" mass="89094" checksum="50414D4A833BFC91" modified="2023-02-22" version="1">MPPKRQNEQFVDESQKQTFGDSSKDNNNGARKFKQEKPDNDVIILNDDDDDDRKPLLEKPALTKRGRKPRWDKQQQEQEELPPKKIRANESDGDEKSQTSVFDYPTIFWKLARPKYGTFTFMCKDCQTANFQMGDRRFMLTPQNGEGRLEFTQTFCRDCAKLNFDCTDLIMKHQKKDAPTKNGHYHPYTGGNNTPGFVGNKTNKFKVHLPKKLVFEGPGWMVGMSGIIYPNSWATVGTLEKQYVIVHLRDGRKYRFKVPRESFLSPQQLERGIHHGMIAEMERLMTRKRAAFQEDEEEEGELVDVQVVEEEEGGLTGLQVAKEERKESVEAPLLPMSQTKFASEQAAERTRQPPLANVRPPEQRGAVRERELVPPNETERLAQEKENERKRKAQKWIEDGRKETERRRQEALQGAASKKKEEEKLGTPKQAPQQAVNEMLEKQKEEERLPKQKESPGKKEENRLAKQKEDPGKKEEDRLAKQKEETEKKEEESSAKQPEDVGNRPNNGTERAVNPAGEEERIRRDQEIKFKLRELELLKELKPYRGGWMRLVQGKDPTPDVHYLHEKDEYHFSNAVDKYRIHHPELPWELPEFNPSAQIQRNIAEFKGLFEREVYDENYGSKTREEKEELIALVKGFRFYYMEDIGRFMLKIFDNKISHITLTDQLAYVLGYEQEQQILNEDLAKYSVDLGGGVSHLCIYLNSGIIESMIFGNTCANLLQMIAVEGKSGSVVEKDFQSPLFHKIIAREVDVLDVEIRTLTGRYVYAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H998</accession>
    <name>A0A914H998_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H998"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14444.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14444.t1"/>
        <property type="gene ID" value="Gr19_v10_g14444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14444.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31065" checksum="A6A41AFC25BA0ED9" modified="2023-02-22" version="1">MDCTAIRIAAVSGVDPWILTIVIVKSLSMLFQLFCAYPVFKLSRERFALYILVSKLFPAIFGLLASIIQRAAAYVPPSNITDFFVTYIVIPCAIFCSISNRLHIIALATNRAHAVFFPFHYKQKMTKRLIFVQCVFMHLLSIPITFYLYNFKTPAYYTGSYVIVSSLFYAAIVTKFAWIKAHNRNWGTEVAASASDKDSVRLTLTCVAIQIVAMCQMSYISANMRTNCRQLLGKVWPFTTTKVAAIDAGLNTQIRNINVNVVGSNRLAAQQLGQPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9M4</accession>
    <name>A0A914H9M4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9M4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15324.t3">
        <property type="protein sequence ID" value="Gr19_v10_g15324.t3"/>
        <property type="gene ID" value="Gr19_v10_g15324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15324.t3"/>
        </source>
    </evidence>
    <sequence length="330" mass="37948" checksum="FAC83C9CBC26D08B" modified="2023-02-22" version="1">MDQKETNDKIGWLNDDQQKISVSVDHFLVGQSDQKALLDRLNGLEQKQTANSDHQKALRAMLDQGMNQLKRDLMATMGKCKQQQTIDVLAEKLNIAIDHFYRLQTTISDLEHKQQNDQKELLREMNESLCPINGRRRIRNWDYPLKTDGIPLHRILSIALGKIALRWADEKCRQNGKECSAENRREMLGPALFKIRFPRMPQKDFSEIIVPSGVLTPDEIISVYLHYSHPDADQPKLYPLQFPTKRRTATKSSGDGPNWSWVGSATLRIISQKEGKKDFTQTMSDVFWPYPPLTLSFEKLMDPNNGWYDAKNDTAILEAELTADKPIIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBM6</accession>
    <name>A0A914HBM6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macro domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBM6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16022.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16022.t2"/>
        <property type="gene ID" value="Gr19_v10_g16022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037517440" evidence="2">
        <location>
            <begin position="28"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="320"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16022.t2"/>
        </source>
    </evidence>
    <sequence length="617" mass="68667" checksum="D954B45C4B24B3BE" modified="2023-02-22" version="1">MNSAAFPLLSSALLLLSALSPPAIVESRPPQINGILPKRRSQVYPLQLLEDEKEQMADKERQNRWFADEEEEENDGDDGDVLDEEGRFELSGRGGAERDGPSAAFWSNALGPFLFVFENKDRRNSRTMWRLTIRKLNRMRRDRLGKDFAQLAWDNQLTNKVRQISFTELRPLSVVIKNPVNGVASNLILGFQTLFSAFIWQNVLCSRGGACRVAPSKRRIPAELADSKARRIGCNARVYKEADKRELRFAAVCATERSAGEGQNGTLLNLFRLSELQNVRLKKKLRWEAVDSFEKGEEGGEDEAAVDDDDDDDDEEANGKPLAKNVQPKASPVSVHSGDIVRVRADAIVDPVKGSLFAALLQSPVEEAVDRVLGAESVLDVLEMDEEDGLGKTMVRRQLRRLTELVDPTGNGTALKKAAKDRAARAKQQLEHWLQALKVPQTFAALQAEVDAWRQRKNVSAGADQRILVGGGPALKEKLRELAQRRGGGGALVPGDAVATDAFEISDKFFAKTIIHTVPPSELITQRDFEKLADCFRRSLEVTVSRGFSSVAFPEMMARNASDKVKEQAARIGVDAVAKWLSEHPNGKVSIILVVYNNPRMFKQYKQLVEEKFPNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDQ8</accession>
    <name>A0A914HDQ8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HDQ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16192.t3">
        <property type="protein sequence ID" value="Gr19_v10_g16192.t3"/>
        <property type="gene ID" value="Gr19_v10_g16192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000013">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="95"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="356"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16192.t3"/>
        </source>
    </evidence>
    <sequence length="486" mass="53436" checksum="AEDCC5B941036DBE" modified="2023-02-22" version="1">MLTALGKNISSVDDSGLELSREMENMHVNSISLDEDGVKQYSICSSASSTTSCPDEAAKDKIGPGADLSSEDPFTVIELRDVCRDGTVKASPSQFELLRVLGQGSFGKVFLVRKNCGTDRGHLYAMKVLKKATLKVRDRLRTKMERDILAQINHPFIVKLHYAFQTEGKLYLILDFLRGGDLFSRLSKDVILTEDDVKFYMAEIILALEHLHSLGIVYRDLKPENILFDSDGHINLTDFGLSKESLDEPGQVTYSFCGTVEYMAPEVVNRRGHSVAADWWSLGVLMFEMLTGQLPFQGKNRHDTMNLILKAKLGMPGFLSPEAQSLLRALFKRNPANRLGGTADGASALRTHRFFASICWQRLAQRQIAPPFRPAFASGIDIDGNATAATLDVAHYFDTEFTKKTPKDSPAVPPSAAAHELFRGFSFVAPSILEEDEDEFGATTPCCSTAGPSSRVPSPLCAVDSSALAQRRRQQRGGGSGNPFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDV5</accession>
    <name>A0A914HDV5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome-recycling factor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome-releasing factor, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDV5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16598.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16598.t1"/>
        <property type="gene ID" value="Gr19_v10_g16598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="6">
        <location>
            <begin position="135"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16598.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33688" checksum="410E0F02D67F789F" modified="2023-02-22" version="1">MRLIPSCHSFCYFRLLARKNFATSVASSSVLPEFLTPKSLIGQLQQPFSTTLCLCNNKQIKRGKKDRKSTDIAAIKGTVSTRGVLVDDDEDDDDEDDDGGAVKKGKSNSGSSNNAKALAVEAMHEMEEYLKTLNDALIKHLSLKVNLKVYEDLSVTLENGETHRLIKFARISLKTPNGPVVLNFSDNPAAIKPAKLAIQSMAENVSPQMDGIVIHVPIPKLTRERREELATHSAGLILNEYKLALNEVYKKYTKLLDRSSNNKELVVRLCNGLLAEKRKYDKMGEDKVKERREILLKEIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDW6</accession>
    <name>A0A914HDW6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDW6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15724.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15724.t1"/>
        <property type="gene ID" value="Gr19_v10_g15724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15724.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9372" checksum="A7362490DCEC7F80" modified="2023-02-22" version="1">MDVDEAFIRLQMNVFFFQSVRSGQFVNGGIVAAAAAKEDGGVGAVNGQRKVFAVSPTAGGWLRPDGGSANGDDTLPPGGGASPILFQRMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDX5</accession>
    <name>A0A914HDX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16613.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16613.t1"/>
        <property type="gene ID" value="Gr19_v10_g16613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF1">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16613.t1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51105" checksum="0A58379B34606858" modified="2023-02-22" version="1">MYCTVPFFLAAIWLTVYLAVQRYIYICVPKLVQSLCTIRRSKQMIVSICVLSLWVYAPELFASYNQSFRSTNPFTNRTRSMCVMYQTALIQMMGNNLYHMLVFAVHTIIVHTLPCILLVFFTWRLIAAIRKADKKHCNLIGKGNQHHHQQQQQQQRKFTVITPDDGPGGSARGGGSSNGMTSLLAGRSSSSEEADESCGGCSTVVVTTDMPTTNSTTLFTRTSQQQQQRGSLSESKRVQGLRQNTRMLLAVILLFLVTEIPAALIFGMHVGTVALKFTFLQQRHYAIINKLLIVRNVLIVISYPLRFAIYCGMSAQFREVVQQMLAKRKTLFQHFSYGKLRSRGINGEVRRAGSGRKSEGGESNSNSMAHKTSTTLGMLLHTETVVWRNGVGGDAPFGGRRDEMSRLPMEHHSNGGAGGSGGRLAGQTTALVGDDDERNVEEDEETDELDANTNYDEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE87</accession>
    <name>A0A914HE87_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HMX homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HE87"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1581.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1581.t1"/>
        <property type="gene ID" value="Gr19_v10_g1581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="352"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="354"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="54"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1581.t1"/>
        </source>
    </evidence>
    <sequence length="565" mass="62478" checksum="49CBECB10549B1DC" modified="2023-02-22" version="1">MNLGEIEMQSGEIHSKKGTTTPTLTSAAICPPMSPNVFHPFLYFPPKSVDRTNCGEVQSSSTIEGGRGREGSDCKGTDDDKPRRQGSLGAKAEPKMPSSGHGFSIENILTEEKRRRRKKNEEEGEEREEEEKRPPKIAKRETADNSPKRDAFNHEQQLITSNKQLKREEEQFCSPSSELHSHTLPQQVGPAIASSSLENVTSWPWQHLNALLLQPPGTVEYFMAMARTRESIATTVQTKQREQGQQQQQNIKPAHAFNLSQLLLDPSRHHSNPFIEMGFLSGQIPLIHPTAESPCSHRNSLQGEDGSPEEGFESENEEASNAAKEASDEEGTADVGDISPNGVEESLVEGAGRKKKTRTVFSRHQVTMLEQMFIDSKYLNGQQRSELARTLKLTETQVKIWFQNRRNKWKRMSTDERLADTSFSNSTGAPLPTLSLHHAPPPSFAAPPLVVQQLNQQRHQLVLALAGINATAQNPNALGDSSAAPFHQNQQLNCSAGVSMTQQQVLKADPQQKQSNPIGNMQLVHSEQLLSSSSSTPPHNAFVNRLLNSFSVLPFLAPPPSHTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEI0</accession>
    <name>A0A914HEI0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEI0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16778.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16778.t1"/>
        <property type="gene ID" value="Gr19_v10_g16778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16778.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18797" checksum="4CA53CA895B30C10" modified="2023-02-22" version="1">MRKKKKRFLEHSAWRLDFVPKTNKMPPPPPPPQAKQQQQQQRQQQEQPVEEEQQPQDPSALKIVVANVDVGQAEGNDRRTKNGKFTLAQLRATDGICPLQNGTNQFDSQKLMTNFGTPRDVKGKHLKRIWELEFPEEAADYQQQMPPVNAAPQQQQPQAQPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEJ4</accession>
    <name>A0A914HEJ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEJ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1679.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1679.t1"/>
        <property type="gene ID" value="Gr19_v10_g1679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038127862" evidence="2">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1679.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18506" checksum="7548E548CE8EB44B" modified="2023-02-22" version="1">MWLNTAVVLLITVFIVINGAAVPKNPEEPKQEVPSPEDSELEVKVPSPEEPKQEVPNPEEPKQEVKVPNPEDSELEVKVPNPEDSELEVKVPTPEDSELEVKVPNPEGHISQVPEEHKETVEQPEFAGVQLLREKRLAGNKSDIIELFVQIYKMILQDLEKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEQ5</accession>
    <name>A0A914HEQ5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15938.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15938.t1"/>
        <property type="gene ID" value="Gr19_v10_g15938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="19">
        <location>
            <begin position="284"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="530"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15938.t1"/>
        </source>
    </evidence>
    <sequence length="582" mass="65650" checksum="9DDF1DCD7BBDD230" modified="2023-02-22" version="1">MADNSRRLSDETMAMETDDELPIVRLLIASDIHAAFREVLAVGTDSKVDFVLLAGDLFHENHPSRESQLKVVRLLRKYCFREGHPSLDFVSDPTINFQHSDFPVANYLDENLRVSMPIFTIHGNHDDLSGKGLSALDVLHEAVTPILLTRGNTKIALYGIGSQRDDRLARSFAKGRVKFNRPEGDDPGSWFSILVLHQNRPPRSQLRSTKSHLSFRNIPFFFDLVIWGHEHECLIDPDFKYMDPNDSNKGFYIVQPGSTVATALSVEESKKKHIGILSVRGKEFKLKKIPLQTTRQIIVEELTLEGAQPTAPKIAKSSVRLKKMPDEPLIIERLNELLENAEATRGPHQPWPPRVRLKVIYSGRWLDIPPINGRKWGPSHFADKVANASDMIVVRAIHPEKKAKNVQNEQLQHLLANRADDVCSVDEMVNKYYNQCDFKNRLNVLSEIAMGKQLQEYSNTETTTQFKYTAADKALSDSIRTQINSMTAKVRETLHDRMSMNADAGGFEDIPLEQQIAEGMAKAKKKRLVKVTEGSDDPNESIASSFLDRGFEPSQLVTSTPRRSPKARRGSKNAEQMSAIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFC7</accession>
    <name>A0A914HFC7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HFC7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16462.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16462.t1"/>
        <property type="gene ID" value="Gr19_v10_g16462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="568"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16462.t1"/>
        </source>
    </evidence>
    <sequence length="921" mass="104131" checksum="6671DA3291EF1F67" modified="2023-02-22" version="1">MKFPTIAFASPFSKKICAIHQSSTRNLFVHYSLPTFSAQHLTKEQTRPSSSAIQNKLSEKLKQSQEELENYKPDSTKYRLIKLRIANLREEIFRVGTARLEDPKDLVNISNMMLAPHLVTLEVISNGTTHLRPSVVLRTPTRCYLFNCPEGTARFIHTFRIRPNTISDFFATKAHWDNTGGIASMLLEKFNPNDSVRLHGPKHIKSYLEGQRPFMDVDFGHVNYPVCCEELSYEREQFEDSTLHVRYIPLVVAPSTLSPSPPNSPSSTARGVERGGIKMMGNVDVAFLVKLKGSSPSIDPFKLIALKIPKGPHIAQLKAGTPITLEDGRVIQPSDVYSDKMSAVSPPDLLFVELDSLDKLNAIHANELLKDFMGDDRRLRQLHYIVHFTRPALFNSSQYCAWMRSFGTKCRHLVLNGTGPPMTMNDGVYKSQENLHTIFPQAYPEIYPAPEHYEGKVFTHNDVCDDLLADQPSTADGMGPIFLGSLFQRFPLRGVLPKFGADDPNVLKLDYTVKELDFRLENMPGLAPELVEFRKYLSAALDARTVPDPYPQVAFLGTASAVPAKYRNVSSYLLQLSPSSTMMIDCGDGTYGQLRTLFGPEQCAKLLASMHVIFITHSHLDHTNGLFTMVQERCRAFTELGLPYRPLVLACNRTIRKITSTYAKSYQDIDRFVHYVDLPYIYIEDTVGINPKAVNSLPSPGAVTELTKHFPNQLFSPKAWNLRSVKAIQVRHTRAASGFVFECEQDGRRVVFSGDTKPCPLLEQHGREADVLVHECTFEDGMEADALRKRHSTMRQAFDSAQRMRAKHVFFTHFSSRYARCPPLPDYLLEAGNFAVANDYMLAPFDLLPVFPKLLPVFRELFREELFTNHMKSMKRKMERPNVDDQQQKFGQLKQQKYIKNVAAMGSSRQVETACLKATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFI5</accession>
    <name>A0A914HFI5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFI5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16889.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16889.t1"/>
        <property type="gene ID" value="Gr19_v10_g16889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="340"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16889.t1"/>
        </source>
    </evidence>
    <sequence length="597" mass="67305" checksum="9A9E57334827380C" modified="2023-02-22" version="1">MEVDEATFSSDVERIAALLETKKLVILKSWVVPMAVGKRTWPVGLLLEEAFRSKVLQINGQYTSKNFVGSMKLSRKSGLQYWQMSKFAEFLEQPCVILLKNLNNGGEGLADAITDLAAPDRALQMHVECRILGTISSEDIQENLRVLWQDCTLKMESLQRALMASMLKVRTAESGFDNIRPKLLETFTTASELIQTDKRHMDRTLNSKDLIRVVRRLVEDHQQYTSVTDRCALFTELFDNWAAHLAGTESRRSVAGKTKYFSAIGEALSLSTEQQHYQIKVRHPDVSFLEENEGQQRVRIGRITLNRHEQQQSTERKPFVNTRDAAQLLERVAACVARSPPEPVLLTGDTGVGKTAIVQHIAHLLRVPLHVVNLSQESEFTDLVDGHTPTSTTNFLWLTEATERGDWLLLDEINLAPVECMDALVELLDTSSDFIVHANFRLFACMNFSGDGHINKQKALNELDSALPPVHTQNPLATYAGRKRLSRAFLSRFICLKWDALPPGELSEIVQRRCLLTSDMAELMANVLAELSVLCSSGDSSDCLMTVRDLFRWDYSMPALMDGQATTDWRQALAYQGYFVLGTRCRTEQDEKTVLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFK7</accession>
    <name>A0A914HFK7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calcium channel beta subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFK7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16516.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16516.t2"/>
        <property type="gene ID" value="Gr19_v10_g16516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11863">
        <property type="entry name" value="SH3_CACNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000023">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046937">
        <property type="entry name" value="CAB1-4_N_A-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12052">
        <property type="entry name" value="VGCC_beta4Aa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
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            <end position="29"/>
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            <begin position="189"/>
            <end position="199"/>
        </location>
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            <begin position="538"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010836"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022882"/>
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            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16516.t2"/>
        </source>
    </evidence>
    <sequence length="579" mass="64074" checksum="AEC559C2FE9A49AD" modified="2023-02-22" version="1">MPVGSSANKYNNRRDSNFSHHHDNDYDLEQRNRETIKSNAERQAAQQLENAKYNPVLFAVQTNVDFDGAIDDDAPVHGCAVSFKAKEFLHIKEKYNNDWWIGRLVKEGCELGFIPSPAKLEAVRQSQQSGKGAKFTSRQSASTTNLGALDRMMPTPRTGGSRGSTPPTPGEGDEEGGAGGGDTHRTGRSAGTNQQQMTPPVQKERKKMIFKKQENIPPYDVVPTMRPVVLVGPSLKGYEVTDMMQKAVFDYLKHRFEGRIIITRVTADISLAKRSLLNNPTKRAMMERANSRSSNSLAEIQAEIERIFEFARSMQLVVLDCDTINHPSQLAKTSLAPIHVFIKISSPKVLQRLIKTRGKSQMRNMNVQMVAAEKLAQCPPDAFDVILDENQLEDACEHLADYLESYWRATHPPVRSPPRIKRGPMANRGPVAAAFTPAQMMQGAHFGSPFYHPAGQPSSANDTPPQSQRVPTIAVQQASLPFAPGAASSSNAVHHEDEQYQQHHQQQQQLNNGYTPAGSSGRGGGGHSPRQHQVARGEDEDDDMDEFDEEMDDYGRGGGGGTRRTADLRRNVDDNIGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFQ9</accession>
    <name>A0A914HFQ9_GLORO</name>
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        <submittedName>
            <fullName evidence="8">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFQ9"/>
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        <property type="gene ID" value="Gr19_v10_g16206"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_A2_cat"/>
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        <property type="entry name" value="RT_RNaseH_2"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASP_PROT_RETROV"/>
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        <property type="entry name" value="ASP_PROTEASE"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0229">DNA integration</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Peptidase A2" evidence="6">
        <location>
            <begin position="307"/>
            <end position="382"/>
        </location>
    </feature>
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    <sequence length="765" mass="86140" checksum="93712612DB5A3AC1" modified="2023-02-22" version="1">MAKERSDRRPGHFEYNCFQKQRNFVQNHRPPVNNIQPIPQYLQGANAPPAQPSSSVIVDANELLRAFSAMKLPGPGNEPAPMNSISPVGKKESDGEAKEEETRVQHVQEVQQVTEQPRQGYAASTAGLSNKARNRVERAAEGLVSSSQLASELSYLSWNVSETLSFSFNHAMQSVCEYMEQTRRWALSASSSDPTAFARIAFDNPNLHAKKERYAFVDPSTMIVSSSARKAQCTSQMTFQISKEDTIMKIAPAEEWKQTGKDIREWFIGSWEDLWWQIVSILVIISSADLLFRLYFLIKGKINSVPVRCLLDTGASVTVAQRSLINQINCSVIPTMEEAISASGHLIRFREKAEVWLDIAGSRALIMVYFTEDPKSGVRRDYQVLLGCDSLEKMPLVTFDIQNRRLAIINPTNEPVVFFKGMHLAYVNEVEEEDGILFEQSDGHAYNASLVGLGGVLMQKNEDSGTFSAVSYCSRTLSGSERRWPPVQVELCAIIYALRKQNTLADALSRAAEDVPVQEVQHLPEMEDIVEFPVCLALTLDSRIVLDPFVGTVTMRHADGNSYSVDMAQEQRDDPETDAYMKFLETVTSLRRAWKYASEANEEAQLRMKLSYDRLIRKPTIEIGDRVLLRNYAGKIGTSKKFHFPWRGIFRVIELDGVHATISSCLSPQSNPRPACTVPQIPADEQQVLEQSNAEEVVNMPGYSHRQSQNDKERQQIQNNSQNPVAISEEKSQKVGGSGNTEQSDRKWNLRDRNKISRPKRFETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH91</accession>
    <name>A0A914HH91_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HH91"/>
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        <property type="protein sequence ID" value="Gr19_v10_g17151.t1"/>
        <property type="gene ID" value="Gr19_v10_g17151"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:poly(A) binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17151.t1"/>
        </source>
    </evidence>
    <sequence length="923" mass="102206" checksum="C9233923D1D34DB7" modified="2023-02-22" version="1">MVPQNSEFTRKLRAAVRAKIEEFGIDVDDELPDYVMIMVGNKKDKMRMKTDLKLFLGDKTPDFVEWLFGFFQKVKNATALSSTSSAQQLQNSAEILTDKEKKRSAAERTASKGNGEGKAAEKVSSLAEKPMKREGRTKESAKSMDKTNANGPSSADSSTSLSRERGVPRHPSQQKGRQPSSNHHSAVPKSRALSRSRSPPRHDRGGGGGTKRTPPRRTRPSPQRHGGDHSISPDRKPVVLPSKGPPALRSVVSVPVQFTPTAHPRVHAIARAAQWRRCARRDGVATAKGVDRRRPMPEEQPTNEADVVIPRKQKFIRTIRALSPHSKATLAENTQQKEQSSNVVPAKPPRRRVVFGGGSLIFQRAIQQQQQTTTANSATSPPKEQQKATVVVRPQVRVLSVPFSGTPESAEGDGLMAAEAQPTNKRPPQRLTLIATQQQTGASIFQRAIKETKRQRTAAEDGEGAERRPKRVSVEGVESNNEYGGDEHAEIGARKRPRLEVDQQQQLRVEALKHEDEEVLTIDMSRTIRRKREIRRPRKLGLELVKEHITGAHVAKDRAEKEKEQERVQEQEQSPKPANEHQKDEAEKVERTEAEENEDEAGRGSRVSPERTVHLNRNWTSNASATTTTSAPIWDGRIEIDDMSSTDDEAEIDAVLEDAQRLRKIALERELPPTAALSRPLLYNPLDFSISTETGLISPSDAALLPAVTYKQRQLVMLSGSNSTEQQQLNSNGVTSSIVDGITAAATACASSAAVAQQQRPHATVAPTTTIQAAPATMIVNQQYHYHHQQQQLNQFSHPYSPGYVPSAAMAYHQGGAYRYQLNRGSMSKQNVSMEGKESLKQQVHALREQHKQKSLSLQHQLEEQRLLLGQLQKMAPTAELGHRKEMLLRVRQMDALVGQLKRELNDICEHISSATKSGGGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHJ3</accession>
    <name>A0A914HHJ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHJ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17564.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17564.t1"/>
        <property type="gene ID" value="Gr19_v10_g17564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14054">
        <property type="entry name" value="REPETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14054:SF14">
        <property type="entry name" value="REPETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17564.t1"/>
        </source>
    </evidence>
    <sequence length="1101" mass="109837" checksum="22814CA0E7A89967" modified="2023-02-22" version="1">MAELSLDELSPSEMSTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIRTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPIGTDDPVETADPEETADPVETDAPVETDAPVETDAPVETDAPVETDAPVETDAPVETDAPVETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPPRETDGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDAPGETDATGEKDAPGETADLGGLLTNWMMGKGDLNPNPDRRGHVYYGTAAKGAAGTNAGPSYGNRRYFYAPGELSTDAPGETAALGKTAAPIKPAAPIKPAAPIKPAAPVKPAAPIKPAAPIKPAAPIKPAAPIKPAAPIKPAAPIKPAAPVKPAAPIKPAAPIKPAAPIKPAAPIKPAAPIKPAAPIKPAAPIKPAAPIKPAAPVKTAKDAEDESSSSSSSGIGNFLRGLFGGLFSGSLPKSDMVLKYEHTCGCGKGKTKDFEDKNCAHYLTNWMIKIGFIVLPPKDEPKAEERVPKLQKPPTCPHGRLIRAKDVQKLFETKFGPGKTSPPKDGSPCFVYCENEKKQGHVYFGTAEKCVAGTNAGPSYQKVRLYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHT6</accession>
    <name>A0A914HHT6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHT6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17069.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17069.t2"/>
        <property type="gene ID" value="Gr19_v10_g17069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17069.t2"/>
        </source>
    </evidence>
    <sequence length="299" mass="34473" checksum="35BAEE290063532C" modified="2023-02-22" version="1">MSDHPNVQQRQLRKIYISDDDLLVVRQKIDGNGAALVKIYGRDKPVEVPFPLQPPPDYLIGFTRIAIRYIDHNVIAFLNCIRRLFDTGVVLSLEMHIGLSQMWESSAAVIWPLLSANVIRLSLFNRQSVVLLRRRVSPTVLRDCPADDSAEASFEQALSKWLHTARTDGRPKVFKCCVWQESAFRDVEALKRNFYFPNGDQWCFGEASAKAKQKAGCIMTACVSFIIRLHVFIDGFEPFELENGRTWERLALRQVNDNIWLMKRGPITATAGDWKRWAEWEREALEWNLLNRNLVVIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI51</accession>
    <name>A0A914HI51_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HI51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17733.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17733.t1"/>
        <property type="gene ID" value="Gr19_v10_g17733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17733.t1"/>
        </source>
    </evidence>
    <sequence length="781" mass="87897" checksum="D2A5CA696F3A5707" modified="2023-02-22" version="1">MIPKIGLCHENFGITEALAVHILRSIDCFAECRFELLSNSCDDASCQATVGLGRADMERNCFSNECDSEYTLENLMGIDGYVLTLSCAGQVYAKFGQPLLHQKFNDRYWLTVSAKRNVARDFRKLYEYIIEVVDSWYWGVPLQYPMTEKTQLLEFLEDLQSKMDSEWADKRDTDFKMFVEQCVAEVGRKFDQICAWYMECYLPAFNLVVDTLKKTDDFGVLLLDYNFAKVTLDDLLIRAGNNLRLPRLIIRPSFKKFRLECVRMVKPILYFPREWIGRSDHVMETLDIQHIDYISSDRTYAIAQTLEAAHKLAYRLLAYAEESSNIVTSQECSLTIGRNVEGKQMTQTLRSLPGTRSSSVSRMDGEQSDEAKDQQRKKHLEEAALELKILAGIGTNCEDDDSATPESESAPIMCNGETIVESNSSEEKENTCPLLLLDFDTNTVPAAEGRPSGDERQEEEELGQQQQQINVLATQCQNGCTLREEKQEVSSSRSSCTSSVNSLSTGIRQQMETVQRPQNEHTLPPPMSSNGGCHDESDVNSIVQKVFNAKQVVLEVPDNCFTLSHVLGASFIGFALGTGEQHLQIRGLDAQQPAVDCSIRLGPGIYDYDDADRTFTSSHLVSLFSLDLSSDTMDKRLSIAGLCYAFHAKRAIAKIAAKGSPDRLATLLSRANDAGRRKLTTVFRRVYHRLVRPIDEWVVSGNTHNQQHPLTTREADLLQKALAALINVAHVDNNNVPDQQSANEQRKAPSLSEEERLIAFRTALHLCMQYVNDIVCNLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI64</accession>
    <name>A0A914HI64_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI64"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17385.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17385.t1"/>
        <property type="gene ID" value="Gr19_v10_g17385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17385.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="49529" checksum="0FDE61311E1ED4A0" modified="2023-02-22" version="1">MPCNCQPIQPPPPFDVPPPPDPSLVFHLLSDDPPEAFEKLHTRHSCPLQKQPFFFRLSLGRFLPLAAIAFLLLLASFSITAFALWRRRRRRGGTEAELDGREWRRKSAETETKSGRKEATGGGGKKRWKTTKGKKRASTLSGSCPKNGVLPSSLRRQPHFNINFPISSPSSDPDANFSYRSSTETVSSVPSLPHIAGSEWLFCQPAAASESDVKVGSNVLFHSSPSAAFDTPPRRPVALRLLPNRHLSPDFVWRSSAGCAGPPSNDLYEELAGTDGDIAEAPYKWRLTPSARRLPPPSSKPPPPPTDYPPDWPTSVAQPFANESAETEMEKRLNHPSTALGGVDVKTRPRTASDQMDKERESGYGTGRSGGGRERNQRNGTTEECPQRNRSSSAHPFSPLPHAHVHSQPYGSSTTNRNRQILPIHSKPKDGSDKLRKCREGQIKTMTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLQ1</accession>
    <name>A0A914HLQ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLQ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17796.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17796.t1"/>
        <property type="gene ID" value="Gr19_v10_g17796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17796.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20736" checksum="9ED0C459CB3737FA" modified="2023-02-22" version="1">MKPALADALGRLTRFTLLPVLLRRCAPPPANGGGAFALLNGFRPTAEIKSQLRPLLGTRTSGANHWDLGDLLTLGRGIGDFGTAGYGFPSWPIRPASVLTACQKFLASVGCLRRRRIRLQPQIRHPGHRSFFGDPMHSSRHTLKLTPFTAYVSLFKYHFDFSEGGNGGEEQECNCKKACPAVCFRPAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM47</accession>
    <name>A0A914HM47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g205.t1">
        <property type="protein sequence ID" value="Gr19_v10_g205.t1"/>
        <property type="gene ID" value="Gr19_v10_g205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g205.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14587" checksum="FD0017050AA4305B" modified="2023-02-22" version="1">MGTYFESWARNLLKQMNWPDECEWLANVSAVHLPILLTTDQWAGRGGQQMDFPDTSSSGWTRSTLGSPQQQQQLQQHAEKPRPTNSPHFPPPTHKKASFAEVIEAPQQIKQQHIFVYSQPVTIHRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN09</accession>
    <name>A0A914HN09_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2661.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2661.t2"/>
        <property type="gene ID" value="Gr19_v10_g2661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="1079"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="1509"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="2085"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="688"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2440"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2869"/>
            <end position="2927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2443"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2471"/>
            <end position="2480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2661.t2"/>
        </source>
    </evidence>
    <sequence length="2927" mass="327180" checksum="474DB44BAC417A40" modified="2023-02-22" version="1">MKTGKLALPGWMLINEESGQVRLWTQPIGRTDERPTTALTLSLTRRMMDTGRNRYNSCYNGVCCARANSNPYSAPTNPYFPTGQTYNNNPNSYYPGNQYGNNPYNGYNYPANGYDKPDPTIIVINASPTTGSAGYSNPSYPYNNNNYYNGYNPNNNNGYNPYINGYSPNNNNGYNPYTNNNPNNNNNGYNPYSNGYNPNNNNGYNPYSNNNPNNNNNGYNPYSNGYNPNNNNNNGYNPYSNGYNPNNNNGYNLNNNNNGYNPYSNGYNPNNNNGYNPYSNGYNPKNNNGYNPYSNGYNPNNNNGYNPYSNGYNPNNNNDYNPYSNGYNPNNNNGYNPYSNGYNPNNNNGYNPYSNGYNPNNNNGYNPYSNGYNPNNNNGYNPYSNGNNPYSNNYNGNVNGGTNNYPPSGTGSMGIDCSTVSMAQDQSACNSMQGQCSNPMVAQTCRQMCCSTQYGSVSRAIVASPFIDFSPHKHERYSQAEIAPQRVCPRRPTNRRIALERANVNQQQNNPDPQIALDPTFPHIVAGNNQANDQNGNTSGSIMDEEQLRERLINIEEPNAANELNLEDEHRLLDQGFGNRTLNGEELRAGNRGDRADIRQNERAENARLQNEENFITSTPISPIRASRNQYNLHARNQGAPRASRPRDARGRFLRMPSNLQEGNFANQNANINPVHHTQTQQNLNTNQAHQSNFGQGGSSNEAGREGVTHHQQARANHSHASTQSQQQFGFQAPMQQQPQFGFQAPVQQQPQLAPGQQQLQFGFHASVQRQQQFGWQPPVQQQAQFGMHPIFPIPSYGYQIPAQNPGQFFSNPGQGTILPQESQHPNFAGTQIPRQQTLQQFGNQPAVMQQQVQHPRPAQPTGLSGIECAMILDRLPDIKGNEGSDSIRTFFKKYTEYTSEWPNKKRVTSLESKLSGRAERAYNAALVNEPFLYDNIKRSMLRQLEDTDCREMGAFDDLMNGITRKPNENLDDLADRISSLVRRAYPGLTRNLADEYSIKHLIRSLNNAELALSLELHRRSGMTYDEFVALASRAETTQKAARRGYTERLRQNQSRTFQNERYFATNSNFQSTSRPVVCFNCNEPGHVSLNCNKPRANRNGPDFGSASRNQPPTSTGANRAFLNTRMGTNPAGRSQNFLKQNCIRMDEEVRPDATVAGVKLEPKVIDFLKSELSTDKAESESPGEKPGLVGKMITTEIEVLGNKTTAMLDGGAQISLIFGKFFYDLVISGKLSLQNAGVKRVSTRVSDVNGKELECFGAVLLPVSRKGCNTTNVRFHITSAPFGFDILVGTNALNSFGFCLYDIPNKVMINFEEISQTRKNHVSLIYQTTLKPLSIKQTELHVGSEWNDKDVILTALVDENPCRVEPMVGTVQNGRLIASVANLSTKTVEIEEKTVIGEMQPLCSFGEADDMLSASMTEFGAKVQGAEETQEELNKSQIGEIPEEELAILKKLLGEFDGIFALHENELTQTDRVEHTIDTGDAKPVKSRFRPVPYAYREKVASMIKDYLGRGLIRQSFSPWASPIVIVPKRDGTLRFCVDYRGLNAVTTKDAFPLPNIDNTLLALGGKKIFSVIDFMAGYWQIRMEPNSVEKTAFATEFGLHEFKVLPFGLCNAVATYQRFMTRLFGEMVNDFIFIYIDDILVASGSWEEHWIHLKKTFERIREAGLKLKISKCHFAASEIPFLGHVLTREGIKMDLDKVKPVMDLPTPSTKKELHSLLGFFTYYRKYIFGFGTLAAPLFQLLKKDAKFKIGESELGAIELLKKKISEQAVLWFPNFKAAVEDPKRQFVMLTDASKIGIAAILCQPDEVGHLRPIYFASRQCNRHESRYCPTELEALAIRFGTKKYAQFITMVPTRVITDHRALVSMFKSKNETGNSRVDKWLLTMNSRFILQVEYQPGKKNIIADLLSRSGALASKKVTDESSIPPANEIAHIGEIREGDEPDSEGEIVGEQRKEWVLKTKEGELGFIYEFLESKTVPKEPKEQQKLMSSLHKFALIEGLLYRHGEDGKAHLFVPRPFREKMIRERHSGTCAGHLSGKKIFKQLAEGYFWPNMYGDCIRAAFCCRVCAHARKPRANEPPLNVVKTSEPLELVCIDILSIGPANSSNHYILVAVDHFTKYLVANAIPNKSAETVAKNFVKNFILVLGTPKRLHSDKGKEFVNETLTEIASTLKIERSTTAGYDPQANGVTERVNQTIIGMLRRSTTSAWEWDDRLPYIVFAYNTTPSETTGFSPHYLMFGKPANFPLEKEISLLKNPLYTVDQDTYIQLFRESLHQLIEEARKNSEVARRKMKERYDAQPKVTAAKFGIGDRVMIIVPGAHARSPHRKILWNHFGPFVVKQITKSAGIVVPADKLNAEPLTVPLERLVRVPPGIPNVCTMPKGKNPYKNILNGLISAAALIDRESSGMVGENFEQKGSKIEAERTNCGKVGQLRAIDLFSDRGEDEQMDADGEQETERKGKAADVLSLGSEDGENGENETEEKRSAPNSTLWEVTCAGENHKKCTPLVVADLDAVLDRSGIGIKAIDNPLKALMTTFLLKSDAVVSASAGKKLISLILSADAGWEMATYCGAREDDVKSGAFPSEKDVEDTLREWLDHCHVAREEVKKSGFGPFAMEIPEALITLPEAEREGMRKVFESVPFSLERVRSMIVFKRPNFVTEARVLLGDSNALQLKKLWAKSAFVGVQEGPIAEVIRNFDEVVLASTVRWLIVMVGKDSLLSGETVDGMMEKVKRLRQLCARFPHVKTFWLLPPFINDKKSESEEFGARMRALFRKSKGIELVATTEEGRSVLEIWRYGKSFNSEHVTHSGWMTEKGLSTLKAWITSMVADFPGDRELGIRAIKSRVVRVDGARGGGPGDPFQSRHFAGIRGEGRGGFAPSGGLARAGTGHRPAQLSQGSATPRFQPYPSARGRPFRPHRRNESGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQC7</accession>
    <name>A0A914HQC7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytanoyl-CoA hydroxylase-interacting protein-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQC7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2919.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2919.t1"/>
        <property type="gene ID" value="Gr19_v10_g2919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042868">
        <property type="entry name" value="PHYHIP/PHYHIPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045545">
        <property type="entry name" value="PHYIP/PHIPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15698:SF4">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15698">
        <property type="entry name" value="PROTEIN CBG15099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19281">
        <property type="entry name" value="PHYHIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytanoyl-CoA hydroxylase-interacting protein-like C-terminal" evidence="1">
        <location>
            <begin position="182"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2919.t1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42149" checksum="3B719A70E454DF86" modified="2023-02-22" version="1">MASISTDLDAVVDVFNVTPIFGADNKLVVEWKANLTENFYDVRVNVKIEEFSESPALTVAYDNDLYGGFGGGFGGGFGGGFGRHGIPMNAEKNYKIYLKVFNQLAEGQEVQTHFLSQSFVRPPQGYQYWSIGQMQQLMAKAIEFTVNEGCPGFVPVKCLSRCHSVAYWANVDADNFMPAFPRTDADGHPTRLNYSFPGVFFFALRERNFIWETSPFGTIAKTFSPEAMFEGNPNNYAFYFGDFKCYNTENKPHYVTIVACKNSRAEQITYFNDHLPKLDMATNAFLRIVEGPNGTSSLVMLKTFSVWIDLFITEAFFGPKIQNAPEDVVEKSSHTRTLQRNCSACSLVKTSPKSSPTKAAWEAMNGAVAGPSGAVPSMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQV2</accession>
    <name>A0A914HQV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Anamorsin C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anamorsin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQV2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2863.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2863.t1"/>
        <property type="gene ID" value="Gr19_v10_g2863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2863.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="11745" checksum="B9E57C3AFD4961D3" modified="2023-02-22" version="1">MDTVPAVGSPTRQAQQSPKKNVTSSNADRDLIDEDTLLEPEDLKRPEKSAACGVPTADQTVGSDANQMKAKSSCGSCGLGDAFRCSTCPYLGQPPFKPGENGTVKLSTVDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRA8</accession>
    <name>A0A914HRA8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRA8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3737.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3737.t1"/>
        <property type="gene ID" value="Gr19_v10_g3737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037571135" evidence="1">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3737.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="16559" checksum="ABAFDD357AEC65D2" modified="2023-02-22" version="1">MSFLNALPILLAILVGIVLQNGHFADASCCCCCKPCCCGCTCVGPCQCCNPPLLIKLPRTCPCCCKCCCCKPCCCGGCCCGCCGGGGGRKKRSIVLRSAIEVAKTGKPASPAVKMMASSCRPETKCNCNSATVNTDCPNSVGVVKNRARRMAFGATFLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRP4</accession>
    <name>A0A914HRP4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HRP4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3324.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3324.t1"/>
        <property type="gene ID" value="Gr19_v10_g3324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3324.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27012" checksum="5DF49384618C122F" modified="2023-02-22" version="1">MPLNPIDEIFGEGWWDKDKAKEWHKLTLEQNALHQIDRQNTQIGQIEPNSTDQNPPLTESNHSDNAKNGEQQNEMTSNAEDEQKRKIVNKFLAIKDEFKQKGKFPYKERMKAELKRAGFKKSYKEINETVAKELGLSIETIYKWKRKLGQNKPNHKHSHSEQKELMKLYYEIKDQNPTMSVGDIAKMLKIGTNTLYRWKKQFKLQQLHPNSVDSVENAGSNVQEIGNSNSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRW9</accession>
    <name>A0A914HRW9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRW9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3674.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3674.t2"/>
        <property type="gene ID" value="Gr19_v10_g3674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3674.t2"/>
        </source>
    </evidence>
    <sequence length="130" mass="13589" checksum="CE2BF263D3D4C817" modified="2023-02-22" version="1">MTSSMIPSLGQGQLYGNCPPGNYADGSCATLHVCIDPHERCINGICCQPMDNMPFGYGSGFPLPAWHHGPIGSMIGGGSCFDLEESCINFVQHCNVPSVTEVCTHTCGLCHNQPPYVPLPYGGGGGIMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRY5</accession>
    <name>A0A914HRY5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Porin</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRY5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3180.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3180.t1"/>
        <property type="gene ID" value="Gr19_v10_g3180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3180.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="30343" checksum="4313B15335D58CD0" modified="2023-02-22" version="1">MENVNYFDVEEFLHRLGANHVLGQTTSWGKPRLGANHVLGPTTSWANHVLGPPTSWGQPRLGANYVLGPTTSGGQLRLGANYVLGPTTSWGQPRLGANYILGPTTSWGQLRLGGPTTSWGQLRLGANYVLGPTTSWGQLRLGANHVLGPTTSWGQLRLGANYVLGPTTSWGQPRLGANYVLGPTTSWGQPRLGANYVLGPTTSWGQPRLGANYVLGPTTSWGQPRLGANYVLGPTTSGGQLRLGANYVLGPTTSWGQLRLGANYVLGPTTSWGQLHLGANCVSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSC8</accession>
    <name>A0A914HSC8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSC8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3781.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3781.t2"/>
        <property type="gene ID" value="Gr19_v10_g3781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3781.t2"/>
        </source>
    </evidence>
    <sequence length="411" mass="46875" checksum="C48ABE8E4EA7200D" modified="2023-02-22" version="1">MEWGCISNMTQLYRQKVDEFGFDLYKRCQFHVGPSNDEITIKELTRFCRSPINKHLQPNSEISLKTKKTYNMKSKLRLTTIRTKKYVNDGQKFEDRASAEDTEGTSSAAIDETEAEEISSDSSEEFGGETGCLSLATQKLKRRKVSHDKAVAVPNISGGLSKWRQCYSDKYAFVEKSEKGIGYFYCRACNAHNKFQKIGERAINVHVTSNKHAECVRSLNRVAPMTAYVKRTTASEEKKAIAAECAFAFHSESFNLPSKRFPSHLSVRWLTLGRLCSTIVKQWPVIEAYFRSIEDAPKKLANIFAEDNHQRSLEHKYLLQFASFSLEQFNAANSATQSYFDEPFFGAETMDTLESFKKFYSDSLGYLDKWLGFLAEYEDFGWIAFEEISFDKICSFQKVLHGCTGRAGQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSW2</accession>
    <name>A0A914HSW2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4340.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4340.t1"/>
        <property type="gene ID" value="Gr19_v10_g4340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039886">
        <property type="entry name" value="BTBD10/KCTD20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039885">
        <property type="entry name" value="BTBD10/KCTD20_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637:SF0">
        <property type="entry name" value="AT10158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16017">
        <property type="entry name" value="BTB_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="57"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4340.t1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52604" checksum="FFA4816E5BE17130" modified="2023-02-22" version="1">MMKHTAASSNSDSKDSSWHRNQRSMSLGGPAHESLLSKQHSSSPPQTVELSRAENGECVVLVVENARFVVNPALLVTKPDTMLGRMFAIRARNATNNLSANVCKDVIDRSSPIDLVRPNERNEYDVAEGISAACFRVVMDFYHRGIMHVPQSICVAELREACDYLLIPFNVHNVKCQDLRGLLHELSNEGARALFNQFLEDVVLPQLVISAERGERECHIVVLLDEDVVDWDEEYPPQMGEDVAQVVYSTPLYKFFKYAENRDVAKRVMRERELKKIRLGMEGYPTHKEKIKRRFNRSEVVYNYVQRPFLHCSWEKEEARSRHVDFACPIVKSKSNPSLASAASDPLPQPAPLQNTNDSAEGAALSVGHHVNFEQQHHTHNGDNEQHQNGQSIREQLQQQQQQHQNNIEHGNLPSSSQHSQQPLFLNVGVPNNSNNAAAAHLSANGNIQTRQPLRSPPANVPSSSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTN0</accession>
    <name>A0A914HTN0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTN0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4567.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4567.t1"/>
        <property type="gene ID" value="Gr19_v10_g4567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038069833" evidence="2">
        <location>
            <begin position="27"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4567.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23074" checksum="539D1DB7D398B7E7" modified="2023-02-22" version="1">MLIKSGRFLFVFIKLLFFVNIDEVSSCALSIFNDDGCCKNNFWGSDCNGLFKPNCNIFEANCVGCTYIYNKANACSVRVYCSCYYCCESKYAESCPDGCWRCVKDGEGGCSENMAGNFKSIGGNSSSSMLETKTKARQHFDMIDVDKNGSISLNEAVDHLGSKLDNGKTTGRNVAKNVSWFAEIDRNANNQIEPGEFDRSLIGGNNQTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU46</accession>
    <name>A0A914HU46_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectinesterase inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU46"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4696.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4696.t2"/>
        <property type="gene ID" value="Gr19_v10_g4696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036780927" evidence="2">
        <location>
            <begin position="25"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4696.t2"/>
        </source>
    </evidence>
    <sequence length="455" mass="50270" checksum="CB6E02BA593E7B26" modified="2023-02-22" version="1">MASSSSALLAIVAIVCLLCKCCISAPQFPCCPGSQKVVALMAGQVDAFSPAMSKSEACTKADIVANTVKTSLNAMTKCTDNNGGGKTIVAEINAKLQSTDECVYSLNFVKAVFELAASAARHAGGNSPAWAKLIEDFDQQINFIDSIGKKHNIGIMNAGFEYPIKGSDAHQNVPHPDSGWPSGFFQPEVPFPILNLEPGSWNTNGGPVRFGAITHNLYLTKHRPKLMRMRWLLNNNKIPKIIQKSQKLLERYLMVKNGIEKIRENDMQLASMVEHLSVNSAELKKDIMSNEPISENRIFVIKSSISDIIDKMATKVGVNLSEIKPSKFKNRFELFKLMLQLFKYTNEKNHLMEKEMTKLFGFAKSFLQESSNSILNANKTKQRRHKRHFGYFVASIVAGTVVAGTVVAGTVVARFAKTPRPKLSRITNNHAQGESMQIKAIATLRDRLKLKVPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV72</accession>
    <name>A0A914HV72_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaoptin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g4787.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4787.t1"/>
        <property type="gene ID" value="Gr19_v10_g4787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF387">
        <property type="entry name" value="LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN SMA-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4787.t1"/>
        </source>
    </evidence>
    <sequence length="1381" mass="156228" checksum="60CE8DC9A2F297C2" modified="2023-02-22" version="1">MSPPPAKPKLNVLHDGSLASSPLNICKIGKASDPDGWAQCQCNFLNGEAASAEPQTMRRRMLVRGMPETVGGEEAEAAGIVRVNCEGMFWTSLANLSGIWGGDEGALWSSTKGGGATTDIGQEFKQLSHPSVGALSIKKTFVKAIGQDTFRSEPNIHFLDLSANAIESVNANAFRGLEGQLFHLDLSGNRFGQVPRWSLTYLRQLQHFSLRDNRIESLHGDTFAELHLRNLRYLHLDGNKIDLVATGSLASLPLQVLTLSNNRIAQLPNGSLPKQLWLLDLKNNFLSEVPFAALDGLNSLRIIDLERNNITELGTHSMGWLKAELDLRLALNRISRLPEGAFDGFRRFERLDLSHNQINSISEKAFQAVESVSELDLGSNALLQIPQNAFLRFANSLRRLNLEQNKLGELPKALQPLISLQQLNLNGNRIRTLDANALARFRANLSELSLAKNMLGRIPSEGIQGMVSLRSLDLSDNAIESVGKMAFGSFDGLSPSGVSSLQRLSLAGNRIRELTNPGAFIYLSNLIRLDLSHNRIARLTKDVFERLDSLEWLSLDYNKMLEFPRNTLSPLNRLKHLSMEANLLQMLPNYAFQWLVHLQWLSLAKNRLSSINAKMFHSTSAIQIRWLNLANNRISRMETAAFQNLPNLERLYLSHNRLTTLHTQILSSLKNLRQLSLAHNNINTTQESAFANLPHLEELTLAHNRLRTIKEGVFHKVPSLARLDLSHNRIEAFDLDFLGASQVYQLRALDLSFNVIRKLEIQSAKYSLRSLDLHNNQLEFVHGQMFQGFEQLRSVDLSQNDLIDLNAGSFWSSTRLERIVLSENNLRTIWRDTFRDQNLIIELNLAGNVLHSLDSGVFGKDNLLGLDLSRNNFSAIPIRALTSVRGSLSVLKMSRNGVKVLNRKEFEGMKNLNVLELAENRIETLEEEMFSFLPKLKHLDLSGNPVNTWSPHVFLGLSPFTEHLDLSRTGLFSLPKLHKLSSLRYLNLSGNFLYELPPTDTDPLPALQMLDLAKNRLVELRAQLFDKISEVRMLNLSDNIELRSIDGALLKGLGQLEILSLVRMSALSRLTGLSDFAYLLRLRSLEIFSNPSLSSENISQILQLLPPLRSLHFESTDEVFSGRELAKADLRLLRELSITGANIKHIGHNAFGRLRGYRLHLSIYNTQIRHFPPEALNHMNAVTFLRLFLRNNRINTFDPFLPGGQRTVLNERGTVLEAVDLGANPLKCDCRMEWLTEWIAQQKMNVQAEKQWTETKELLRKAECGEKDAFEEEHRRDRNAKENLLDTYEGAQFIWYRTKNGQPFRQFPSAEQNHYDYGLNDRFDGFHQQQQQRRMGCDEDGRRLNNSAEGTWRTANLLWLLALALIRATETMAQRVPAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVJ1</accession>
    <name>A0A914HVJ1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4884.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4884.t1"/>
        <property type="gene ID" value="Gr19_v10_g4884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037597006" description="polynucleotide adenylyltransferase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="2378"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="12">
        <location>
            <begin position="2074"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1456"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1462"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1563"/>
            <end position="1579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4884.t1"/>
        </source>
    </evidence>
    <sequence length="2378" mass="276127" checksum="4167D785D1A6CDA1" modified="2023-02-22" version="1">MNINLATIFCVIFIFSTFIEHSRGGKGKKVAKQNAAKSDQSDGISDIATIDKNRQCPEKGDLAKNSETDPDSVQFVADFKEFLSLNASGSLSADFTNTFRINSLIWHFTQKIGDLLNADVSKFNGNSVNEFAAKMTNFRMKWEEIKGFQKAEDFAFVICILYQFASILIRETISFAKQMPEWNKCIRESRLNDLITTNEVSCERSEAEIIYSDLMSSEKISIIYGQNLANLLELSQNFRHYFCHDVKDMGQMKLELNKLIDPEEMNILENNFPEIMRIDLTLTPTLFIRCETLLINRSSSEQYRETLMNWTVGQLIGEMIATAELCQKKVHKLNLSASTLEALAGRIRLLYKSAYRNLQSEEHLCALIKLQQFVNSISSKNIYKINEKLVKRWQGLEECAMADERQRTVAQFRQSDTHADMFEQSLQKVFRYMPDRFRITLRLPGSKTRLAKLMGTRKRFEKLIGDEGLLKNVFTRDLFVDDSRLWAHYKLTFQEEKYNDALWLKCCKIGTDLIVFMRWVKRKLDKIDRPALWDKMRDFVEDELYDPMFDKDEEEMDKFEKILAEIFARTKIFISNFGEKNVKMFFKKWKETVVDEALKGQETDKNAKEHLEWVEKMHQKEFKALLDNEFMADFGQMIVLSQNNKTIKKNMQIFFTEKTIGVLCKEIMAGPFFVGESSKMAAGEVEEGAETTGDEHQQQQRKLTENTTEIEKHLKQMLWKGAKASGDSQNNNSNSLTNLTQNHFACPSTEEDFQEEQSPLYGSLKEMGQSLLTTYLAFLSDTSRMDVYSIGGKGLNVLVIELQGVLWWLLSLCERLMAIASALAVAPTALVDVRAEASVLSQQWNELLEVVDGLSLAEQKVFFLHKFARFLCRNKTMWDNSVEWTERLSNDPMLNILFEENETELSDDKWTVPKYEKTENVQIFVSLTADGNSQIINFFCISEMIERFKAFRWFFCNMNETQLESSKMKLGILVGEEELVTLEDLYPEVLQIDVPTPLVQSILYKAHFRVPSNSYSMRTGARLILPLLLRRARECCNAMPKLVDRNISEAFNDKFRPVQLTAFLALRKGTEKPLLAAVCLLQKFTKYMQKSVDLYRLDGGAIRAKAIRNWTDEKCESDAEEQRRAYQRNVGGFYKFMRNTRGARSRAAKFLTGKYKNLLEELRSELTDPQVFDDLHLKRDYLKAIFGVDTIGQVVGNLSAQISVWVRWMDSELSEKQNSHRTIGLKKVDEHVWSKTRPDFEDMYDELADRNLYELEQQGYLLWELFPRSKEFLDEKRTERNWDKLGIRPSMDRGGRKQTAMDREHCLMAEWAQMMGEVRRKGAEMRLPEEETEQERWMKRRHWHTLITLFADGNFRQRLISGFDRDEEAKTRLLNFIQFEMRDNFMELLNVTDEKEFETKVKMLKKKMDSGGDVKTEEETTGKTKAMLADQNMKKLIREEEKLKELKKKIAERQLEKRKRRRENEQKRKIERERRREAKNSDEAVETAPRTTPFPAETSAGQYNSEDEYAESPSRYGDSPSRYGESPAQSPSRYGDSPSRYGDSPVQSPSRYGDSPSRYGDSPVQSPSRYGGSFVQSPSRFGCGESPSRDFGSLSSRRYGSAIKIAANPTKLKKKKLEKDLQNELANLELSDFASDEFLHSKYFHFLTNPSETKRRLLDLGVFANEIWHRMEIVSNFIKILECKATEIGKSFEYHRMKQLEQYLLKEFQQNEHFLTHIKTEGDFDESAAILHNLLKRTIFELEGGENSDEFDEKTNIGWTTEEMKMVRKQLHRNKLAKALNSDQKHLSERNAKSFWQTLEENGQSNLLMKLFVTSKPNLANRFKEHLEGWRALLAQQRIDAKLHEQFVGKFEANLGTNFPENMQQIYFLNSEDAKLEQSLIALLSEHGFAESNSAVFALKALKTIISEWSVGHAQLLETGSYLLGAHTSNADIDTICIMRQRFVTQTEEMNAFFGTYYCDLSLQLEQRICEDNSLYCKLCKHPNVDFLNKSPRAYMPLIELKFMGIEFDVSFVLISDIESLPDEPLDATDVEWIMELLALSPEPREAMLKSLSGFLANQRILELMRNKSNQRKFRQLLWSIKFWAKSNYVYGNIFGFFNGASLSILTAKVILWYPNSSIPFLFEKLMFILTNWKWPMPVKLIEQNAKNNFESLSWSPSAEESAALIMPIITSSKLAQNASQNINKSTFRIIQNAMREAFAQLRILRNSPINSSADEQNFWKNLFPVKEFTKKYDHLVMISCMVSAPQHINQFCRFVERKLRFKLEDFDRTLAESIEYSHVNPNSHFANESKKCPKMAQNINLQFSLCKQWLVGLKMKESNVEGGLKLNEEIIQLLKEEVRKVDEKIFKEYSLNVLRGRYQHIGLKSQYIEASKLPEWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVK8</accession>
    <name>A0A914HVK8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVK8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4577.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4577.t1"/>
        <property type="gene ID" value="Gr19_v10_g4577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4577.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18917" checksum="E5163BD6CE5EC7DF" modified="2023-02-22" version="1">MERTLQLIRNICGHNYQMFTEYLWPTFGFDFEAQNENEVGDVDTLSDLNEIEEKMKMEVEEELKKEKQLEEELKNAENHAKTLLKRLKGLEQKQMTNSEQQKTDQKALNAMKKYQKQQQQTIDALTQKLKGGHPVTLRIFPHSVLFGKANERNLVDQNYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWF7</accession>
    <name>A0A914HWF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4776.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4776.t1"/>
        <property type="gene ID" value="Gr19_v10_g4776"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g4781.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4781.t1"/>
        <property type="gene ID" value="Gr19_v10_g4781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4776.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4781.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16626" checksum="742DE6CF341A19B3" modified="2023-02-22" version="1">MEFLEDDGRPPMLDGPFTPTRNESMAETNYSDASKDFRLADCLPILESVARAYDCIYPLPKLGRDHHMSGCLLIRSLASANRLYIFEWEECLELKGHLEMEDGSSKRVLHEFYEKYDGIEGLGRFLRECLFNFFYLMYSAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXA5</accession>
    <name>A0A914HXA5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXA5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4637.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4637.t1"/>
        <property type="gene ID" value="Gr19_v10_g4637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="6">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4637.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23420" checksum="B7AB769EAFB49BB2" modified="2023-02-22" version="1">MNMILLPAARINSVHSSNLLRASIRVNSGKIEFILDTGADINVIDESAQKAIGSQPLKKCSEEAVLFDGRRANSWGKALPISNQKSPIRTAILRCKIWSIEPPRSSNNGRFWSPPGNEKFAARKFHSPISTNAAEKVREIVEKLPQKYAQIFEEGLGLCTKIKAHLTLNPTATPVFRRARPVPYSALPVVNGELERLEKIIGKICPVSSAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXB2</accession>
    <name>A0A914HXB2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXB2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5336.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5336.t1"/>
        <property type="gene ID" value="Gr19_v10_g5336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5336.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28008" checksum="4650F3C9B000A6AC" modified="2023-02-22" version="1">MPSSSLCRFVFPISPDSRPSPQAPNAIASPAPFVIAIGGRGSLHVKNGGQRQNRQKQKLRKKQQQKQLQCDQATFHVGLNSAKQRLIRRCFPSVETVVTFLAVVLALGTVASLAIAGWTFHQMNEQHKLCFETMNGQEERLGELESAVTRQQQLETDLKRLEQSIGKLGRMVGARSDEAKFLVNKTMPSIAESNNKNNGDRRIREKHVQYATGTTPQATGSERDFVIYMNGRPMSGRQFVAHGPNGKLRLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXH3</accession>
    <name>A0A914HXH3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5379.t5">
        <property type="protein sequence ID" value="Gr19_v10_g5379.t5"/>
        <property type="gene ID" value="Gr19_v10_g5379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036673073" description="polynucleotide adenylyltransferase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="12">
        <location>
            <begin position="2070"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="13">
        <location>
            <begin position="2243"/>
            <end position="2383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1735"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1759"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1759"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1784"/>
            <end position="1934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5379.t5"/>
        </source>
    </evidence>
    <sequence length="2543" mass="295369" checksum="1D3B73BF342104F2" modified="2023-02-22" version="1">MTSQSYLNHFALLAFVVFNFPLEAFCCIGFSAFSSLSASPVHYPSFCCGRHLDATNLVAKGVPNVPFSWSKNIDMRAKKCQSSEIASYRTNEVRRLVTLYQFNENQGERGAQMSCAFDPSESCAWHNAEQIQFGRQLFMRARFESPKFSAERFDCTGGERAFPLEGFFLLVGGRDESVLESSAAIEAKVPCQIEKAMLKLDYWSINETPILKICVVPDYEENLVPLCEESKIDINPLTFEIPQNERPFRLRIQVDNIVGRDDIVLIDNIRYEGNICLNAPKPPTKSITELLMSKTPIGGEEELEAVEGKLNDEEAQESGAEGRKMEQDGTMGGKVPTGEEFELFGPISRGDDGFYPEEAMRQKSFKNKKDFGRRFRSFHRAKDEAFGPDGTSLCAALKCNFDAGKACRYSRKGIDAMSSWKLHGQCQIGDLEESEDELFVLESPKLRVNESILLVFDLFQRSVGPQLRVCLNTLRNCSFENPRKPHKAKHWLVGQKVILPRGTEKVFFVGSKLQYGGTSSTNVDDTPEKEDGTQLLANFMDFFKASAGNNAAARKIALNLRVNSILWFLRRKVIDLLNFANVLFANDDILVFLLNHAQHIESLTEYLSEEIPSDIFQIDDVFLNCNINEQIERIYNKLQDKIGDINGQNIVNLLDIYDNFRHFFCLQMDMRRTKAALYTLTSNKYVIRIEDQFPEIFKIDIMFNPVLLERVRQLLMSRSCSTRFRSAFMRLTMALLISRLVEFESRISGIVRLCEQMRRELKEKVNLAVTAAYRNLLSEENLCVLIKLNEFVQSIGPKKSRKINEQMERRFWVTDECGSEMERAKIMEKFRKDGLGELYKEAVERTVAYQRKDFITLLRTPGTKTRLAQLIGSDQKLDELLRNPELGTVFQEITMLRTDLLWKHYEIVLLNNNSLCSLNAKLAADVTVFFFWLRTAFIKVLNFNGTEKMGQNLTIFFGANALDEIITEFSIGKFKAAPIKISAENREKSAESEATDGEIHHKSNESYADNSHEQNAKGLNANANEYEGDENIVPQHVQCPPSDASLAQLRALDNERANNEAFVHGTLQTFLAYLKRDETNLGPSEKHKNLMEMKVYGVLFYLHAFFNNLMEFAVKCVADQPFGSLFDLELKKVKKQREELLDRSETKWAEVFLLSEFIKFFLNNKILWENSAHWQGRLLDELMNSLGSKKTENWVKPKYDDISTKTYFTNLNDSGKSDSMHFYSITELIRQYLEVQRFFCDLSDSTIIQNVKRKIAVIIGEDYLIELDEMFPEILQIDALIPLTQTPLYKRFLDSKSGTEQQLLIECRIALPLLLYRLKWFIVKAPTVKGKILDAFREKLGQIRRIAYRGLRRELTGIGRSNLTRECLLRSICIVHRFAGFTSATFALSGSAKEAVKEEDISSWSPEGKCDGEKALRAAYQELHFLLAKTHCRHLTVFLRTNMLNLRGFVREKRGAKNRIRKLVNGHDEFMHEFRVELKDPNLFTNSRLMDDYLDAFFDQDKTTRVVGNLSVFITVWVRWMEHQFLTDDWSSRTTLEAKRVNELMWTKVKLFFEDLYDEFVDVADFDELEQKSNLLRELQRRVWEFAETKHHQLKRTEPKVPQIMALNLGQQRRKFRLDWNNLWEHWHKIVEEAARHKARGVRLMEENREYEQWIDGLHWDMLLTLVGEDETFRKNLKKGFMDDEKAKARLKDFINWEMVETLMQLLLKEETTHFDKELEVIRQREGWGEREIGETEEELKRKSKEENALADQRMQEMIREEEHFKDVKKKMEQRQLEKRKRQRERERLKEQTRGERARSKEEEESEGDKKKMLERETERKEESEGKKGKMLERETERKEESEGEKEKMLEREKEESEGEKEKMLARETERKEESEGEKEKMLERETERKEESEGEKEKMLERETERKEESEGEKGKMLERETERKEESEGEKKKINKLLKAIAGQKSAAAAAAAESWHKLNEMRRHDVLCSLFSKKANLASRFNALLGDWTAMVGQQSIDRNLYDQFAKNNFGGFEVSHLALNFVENTQQIYLNCYDERRHEKLLYEFFKENGFNDCQKELLESELLEEVKSIVSKWSDGSARLVVTGSFQLGALTPNSDIDIICIVPQRLALKEEKDKFYGALSNCDLSRPSAVGRFCEDGSLYCHFCKSEKVQSLLKIPFAQTPLLQLKFAGRDFDITFVAIPDIERLPDDPLEGADVEALSEMLASRGRAPEAMLRSFSSYLDNIRIIEVLKEKNLTKFRQLLFMLKLWAKSNQIYGNMFGFVNGICLAIISAKIILWYPKSSVPFLFEKLLFVLIIWNWQVPITLTNQTEGNFIWTQQSGLAPVMPIITPGNLAQNGAANVNASTFKIMQKQIKQTLSQLKEMNNNEEKFLEWRKLFSVQKFTEKYTNFMVISCVVSAQQHIEQFCGFVERRIRPFLLRFDQIMANFVEYSHIMPDKNLAKGNECPPKVISPQFVRTPYCKIWLVGLNLKEHKIVEEYYGIGKKEFRKYLNEQFNNEFDAKIYNEYDVKVLRGWYQNIKLSSTFVPDPSQLTEWKLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYQ9</accession>
    <name>A0A914HYQ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYQ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5710.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5710.t1"/>
        <property type="gene ID" value="Gr19_v10_g5710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5710.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10985" checksum="00544351FEB92A53" modified="2023-02-22" version="1">MCSVNFAGQCLLQNHGLLYADRNLTLCKKLIKLMRLCLNKPAMFWDKKFRPLNFAIPLEVNKHIKSIFRQKGKLLDTKQMEFGELYQRTNNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZJ1</accession>
    <name>A0A914HZJ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CYtochrome P450 family</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZJ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6112.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6112.t2"/>
        <property type="gene ID" value="Gr19_v10_g6112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6112.t2"/>
        </source>
    </evidence>
    <sequence length="515" mass="59509" checksum="01ABE3EF9877A613" modified="2023-02-22" version="1">MIVLLLLMFSSFIMLSFYNFYYKRRNLPPGPTPLPIFGNLLSIHLSGAGELAFKKWAHEFGPIYTYWIGELPVICVADYELMVQLFQKDAENYASRYNFPILRVINDGQPAFGILISNGERWRQHRRFALRVLRDFGLGKNLLQERILDELRAMFAKIDLIIGQSDNEINLAEFVELSVASIINQLLFGFKFDGENVADFYEIKHLMDEHSEEVGGHSLFWMYILWPDLLRNVPWFKGKRLKFEGRITNFYRYFDKRILDRKAKMERPTEFDAAPSSDYVQAFLREKARNDGTEGHQFESTYQLGMMCFDLWVTGQETVVSVLSWGIAFLLNNEGPLAKMCEEIDQLLISDDTVTDGRRMITVADKAQLPYTRAVTNEILRCANIAPQNFLRTVGSDVELANGFVLREGTCIVPQISVILCDERVFPEPERFNPDRFLDEDGKLRRCDELIPFSIGKRQCIGESMARMELFLFVANIFSQYKVSAGKIRPELKRIPSAVAHCLPFTCRIEKRISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1C9</accession>
    <name>A0A914I1C9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1C9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6389.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6389.t1"/>
        <property type="gene ID" value="Gr19_v10_g6389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6389.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36622" checksum="91981E9CF37683D7" modified="2023-02-22" version="1">MHIIRKCLICGTAEQKKALFDNVCGGGPKTLQNARQLMPDEFGHYVIQKFFENGTDDQKAQLVDALRGHVLTLALQIYGGPVIQTALKSVDKASQIEIIEELTPRSCVIRCIKDQYGMHVMHKIFELIEPQQLQFVVDAILSSPSDSVASLSIHKYGCWVIECVLVHCTEQQKRPVLEQLHGNVLSLVTDKYGSFVIQHLIEHGLPEDRERIVRSLQGDILKNAHHKSICSIIEKCLIFGTTEQKNALIDQVCADDGTGKPPLLQMMKQEFANDVVLKMVDGADSAHRDKMMFAIEEHIPALLKRQQGLRKRTSGAIADKRKKPNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1H5</accession>
    <name>A0A914I1H5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1H5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g601.t1">
        <property type="protein sequence ID" value="Gr19_v10_g601.t1"/>
        <property type="gene ID" value="Gr19_v10_g601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000031">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="769"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="69"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="295"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="427"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="637"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g601.t1"/>
        </source>
    </evidence>
    <sequence length="806" mass="91241" checksum="F856F5A01D95CCFB" modified="2023-02-22" version="1">MSCCFFFICHSSAFIQRVLTERRQISFLQFAMIFFFRHNIFALFAATSVVFGDRRSLYDQNGEFLPHVRLAKDLVEKYDQRVRPVMNHSIATRVNFTMSLYQILAINEKVQSVDLNLWIIQKWKDEFLGWDPHKYGGINATILPHHRIWLPDTYLYNSMVMNREESERYINVIVSTDYWNERRGAEVMFMFPALYRVSCRIHIQYFPYDQQTAHCLGLLFKVISSWTSDIKSIDYWPDSETVNLYSFIPNEEWEVMSFEIHRVVEKFVCCNEPWVLLHASLVVRRKPLYYIVNLVLPTSVITLVAVTGFFTPASTSNERREKLSLGIDSLLAMSILMMMVSEQMPTTSEYVPLFGLFYLSIIVIIFSGTLITALVLNVHLQKTYNRPIPPLITFIFFHKIAPWLGIRPSMVLMELWQETGVCIRGLNDEQQRPRNDSRRRVAKSRSTSRRRHQLQMASTDASGMMALEHMGTEQSPLERSPNDKNAKRAPERSSVGNFFFQMRRISSGGGGGSGNKWKKPPGGGKGGGVDELLTPNLGEPAEWSVMERSIAEEDEAEGPGANPNSGLSAARSVIARRNWRRIAQKACAKHRDALERGQCRSGDRVSEGGEVEEIPFADLSPGRLSLASPVRQLYSTNRTSSSVLSPRLPSPLPPTHPKKNAVPQQLQPASSPTLYHRPPASAAVAKAPVKKPPPVPFKKFSSATQPNKSPVQPVQSSLSPSMPPALQLLLLPSNSKKDPNANAAAMLDLKLRRRFAHEWEFLATVLDRVLLIAFVGLVVFVTAAMMAIGELILRSYPNGVREWHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2R5</accession>
    <name>A0A914I2R5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lon proteolytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2R5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6955.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6955.t1"/>
        <property type="gene ID" value="Gr19_v10_g6955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="1">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6955.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14571" checksum="68AB36AC24190C0B" modified="2023-02-22" version="1">MANAGEQRRRHSPTTTIATNNSYFRRESRAFRHTTNCSMGPPQRRLPSLEFCRLPVDDESWQTAAITGDVGESGRLRMVGAIKQKVEGAIQAGKREVIMPLGNKKDWKKIPLRTRRKIEPFFFITIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3K7</accession>
    <name>A0A914I3K7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3K7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6560.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6560.t1"/>
        <property type="gene ID" value="Gr19_v10_g6560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037803492" evidence="1">
        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6560.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="41150" checksum="19E4B932E868F1E3" modified="2023-02-22" version="1">MSPTIFFAILFLTLATSNAFPGQSFMKCAFGQIEPSCSTAGEFCFKRSPYGGAQNILLDEFYVSYFTAETEQIRQTFMSKIAIYTHIYMLRWKLDQNKEQLQQKVLEKENKYISFYQQHSDNLSKILTLFAEMALYDDALCFLLREWMLSDLLNFIDQRHKLLKYFEMISKSNIRAVNKLRELFIMLVGGSRVALLCNIKELSFICAAPFTPYALMYSDYFQNKKSEIGKWRSKMVLEFSLYNKWGTNFFKKQYVKIRSEAADKCKYIADCVQVQTNFLTIMFKWWVSYSEIFWYNEKKIRAKIVDTLKKTRAKVNLLKEMITKADEHEPALQYAVETGDEKGEVRSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I497</accession>
    <name>A0A914I497_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I497"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g717.t1">
        <property type="protein sequence ID" value="Gr19_v10_g717.t1"/>
        <property type="gene ID" value="Gr19_v10_g717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g717.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28379" checksum="2C3509B0ED465A08" modified="2023-02-22" version="1">MDNNQKQRFQGKVVIITGSSAGIGQTAAIEFAKEGASVVIHGRDVQRLNETEQQILALNVPNCRVLKVQGQIEDEKTAQKIVAESLNKFGRIDVLINNAACVTKPGNEDPLDIANLDHIYSVNLRSIVVLTKLSMPHLEKSGGNVLNISSCASQRFMSARVRPFYGVMKAALDHWTRIMALNCGEKGVRVNSINPGPIDDTLITERDGQRGPVEQKFADKTVLKRLGLPSEIAPAMKLLCSDDASFITGVCLLIDGGVSLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5Q6</accession>
    <name>A0A914I5Q6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5Q6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g687.t1">
        <property type="protein sequence ID" value="Gr19_v10_g687.t1"/>
        <property type="gene ID" value="Gr19_v10_g687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF9">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g687.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18939" checksum="6E8ABAE226764815" modified="2023-02-22" version="1">MVNRSSSSGLSVAVMGKQSSKYNAQEGALLLDWVKQITGQNTVNVDGSRENFVAQLKDGTLLCNLANTLVPGSVKDVVVQAKTKSSSIFQQINNLELFIDFCHKQGVLKQELFRAVDLVEERDLYSVCMTLTSLGRIMVKRGKPGPRRVSAHEIVNLPLADQMRIQEIKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5W8</accession>
    <name>A0A914I5W8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5W8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7187.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7187.t1"/>
        <property type="gene ID" value="Gr19_v10_g7187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037734098" evidence="1">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7187.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10738" checksum="5FBABEC33A392FF3" modified="2023-02-22" version="1">MPNSPSSVPFVFLLTTFVVVLSQNALPLSISANVQSNSNFELIRIVGGEVEHLAISMSRLLRHPRQFMWIMLEASKFESRAMDQIKAYHDLFDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6H8</accession>
    <name>A0A914I6H8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THO complex subunit 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6H8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7764.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7764.t2"/>
        <property type="gene ID" value="Gr19_v10_g7764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7764.t2"/>
        </source>
    </evidence>
    <sequence length="209" mass="23642" checksum="E4E50EC249862D4B" modified="2023-02-22" version="1">MTDNGRWPSFLVRLCGWDRRVSSALASSCFYGIGLTLFGHRLDVRFVCLLFEWALHGAPWLIGSTGLLLWSYINDWPSERINRLCILLVGLLIDLGVVGVLKIVFRRKRPEYNRDDLLYEATFIDKFSFPSGHSSRVAMLSVFGGGFNNCHQHVPLASLFLHFFPPILAVSRVIMGRHFALDALAGLLIGINEGFCVQNIANWIFLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6L2</accession>
    <name>A0A914I6L2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6L2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7789.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7789.t2"/>
        <property type="gene ID" value="Gr19_v10_g7789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7789.t2"/>
        </source>
    </evidence>
    <sequence length="604" mass="69097" checksum="D78C7B4E255DF28E" modified="2023-02-22" version="1">MDGHVRFDPSSISLFSSTSAAPVDDQTRSSVPDEERPVSSTSQAAIIQKPVDIDGGGEQGGDDKREVKFSTYHRKKNMEVVYRRNLIDRLDKLKASQEAFFTVPQLKLVSNNQLSLFLRRLLKSPDIKQHISTEMLERIFMAEELEEKSTDLAKLRRNDDELCQFADRTSANGKPELQRILDEQIHLDEEENELTDQEVTDFEDDEIFGPSDEFTVELHDLLEQDLQILAADRRAVNMQAELRRLIAFANKELEKIDKEEGPCIYEQPIQSDDLEEDSNSSARCRAFLNRPRRSLVRHDFCSSRKGKCKNRPIISKKRCGTEEYAFSDSSTHPKLSLPSSIPLDAQIMKYLHVVDFIPAEIEMRRFKTAQTMTKGQERSLTHAFYNLEEEFREDDDKFGTSESKGIKISLPFRKALKKRQHSGATAPKPEQTDTESDPDDFDYDADPSTSREQMIKFKRRRMTYSSGTSKPSKLENRRTSHVEFGSSMFDYDAQVMDIGLPLPSIQKVENVEIVIPSFRKKSGLLPGFCSPSTDCDRCRLSGEWDEIRRLHADLEQQEKNLRFRPPLGLSVSRKPTPPSATRGYVRYLVPANSPFSAHFSLCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6V6</accession>
    <name>A0A914I6V6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6V6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7171.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7171.t1"/>
        <property type="gene ID" value="Gr19_v10_g7171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7171.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9499" checksum="CA5D2AADD06DC397" modified="2023-02-22" version="1">MAAIPSSNNNCLSSSSSSIIFKLFNAFVHLLLPVLHANRTLGSTIAAVGHPIFSTNHRIKIFWSTTATTVVVGTDVQQRRPNNANIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I704</accession>
    <name>A0A914I704_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I704"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7493.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7493.t2"/>
        <property type="gene ID" value="Gr19_v10_g7493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7493.t2"/>
        </source>
    </evidence>
    <sequence length="523" mass="55739" checksum="95D3E1D844C9F138" modified="2023-02-22" version="1">MAHSQHQHHLLLSSSSQSGSPATPSDQFLAQNAFLLHPSQPSHHPFPPPLHLQHSLMTDFNIPLSEYAQMLTTEASAGTTTATPEGSMIVTPRGQQVQVVQQPQHQQQLAIQIFPTASVDGTGGRSDDEQKPPADPATIIKQAPLPHNSSGTDEEARMRLLKRKLQRNRTSFTQEQIENLEKEFEKSHYPDVYAREGLASKIHLAEARVQVWFSNRRAKYRREEKLRKQGTSLHNQQPQQRNVGDFAAVAGGRATEGGTPNSMAGSSASSNASSSCRTAAARTSQHHQQQQQQFEQTTRVGGTGGAAQTGDASAMLPNSPSSSSSSMPQQQNGVPANVGGDVLRLEGGAIQQQQQSSAAVGARLSPDGPFRSATAAGYAAATAPMSGLGCAGAVPSAMSSAALMHSLGAAQQMHYGGFIDPYLSMSPQDLSGAYNMLQPAGRYDFTRRYHPNINMNMHQTAATASAFPTPPASGAAMSMPGSGLSLQVSVLAGQNSAAHFHNLGTNDWGSNTTVDHPSQYWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I755</accession>
    <name>A0A914I755_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I755"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8126.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8126.t2"/>
        <property type="gene ID" value="Gr19_v10_g8126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20482">
        <property type="entry name" value="CC_brat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14959">
        <property type="entry name" value="NHL_brat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000107">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="204"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="641"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="688"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="734"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="776"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="819"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8126.t2"/>
        </source>
    </evidence>
    <sequence length="906" mass="99128" checksum="FCD50E0BF10B6A66" modified="2023-02-22" version="1">MLWNFEEAISDSSGENSLGTSSSIETDPLSTMLASIVRQPSTGGVAAPIGVMPPGLEFGGDRPSVVVPPPHPNDLGLLDQIGAAGSLSGTSAGSMVQQMVKCPLCQLLYKEPKVLACFHSFCKACLERQMAINTQDLNMPQRIMCQLCSMETQLSPQLGIEGLLSDYGLENAVQSLGSLGTSPYSEQSEDLGFGSLGSGGWPPESVPQCTGCKGGERATAFCRECANYLCMNCAQAHRYMNIFEGHSVEELASPSDSFLSSPPSFGQPKARNFAVSACMCLEHRSQPLVLFCQYCQQAICRECMADHQGCEVEAIDNVAEKQIAMMERLLNEARIKQHGLNEVFQLIDAGQSKLNATFQHTKQTIDEACSFLIQTVHEAQKGLYSQLESIYGYKQLQLTMIEKEVQKVTKKMSQTIEFTQRLLKYSSPTEVIVFKPLLDSRLQGFLTFNADPNNLRDACEIRACALDLQLARQTVYQMVNQLRSDSWLQSPGGGASVSPPGFADQFVPTKTDFFDTNRTSAVARAFGDGAVEQLGSFGSFSSPMGSGAATALGTSAPTGTNGFGTVGGMQDSKWTPDMLASLSLNDTELTDLSILMGGDSSTKLNGGATMNKLGGNDGMAASIPMLYPPRSQIKRQKMTYHCKFGEFGVIEGQFTEPSGVAVNAQCDIIVADTNNHRIQVFDREGRFKFQFGECGKRDGQLLYPNRVSVNRVTGDFVVTERSPTHQIQIYNQYGQFIRKFGASILQHPRGVCVDSQGRIVVVECKVMRVLIFDMFGNILHKFSCSRYLEFPNGVCTTDKEEILISDNRAHSIKVFNYEGQFVRQIGGEGVTNYPIGVGINQLGEIVVADNHNNFNLTIFSQDGTLLSAFESKVKHAQCYDVALIDDSVVLASKDYRLYLYKYQQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7E8</accession>
    <name>A0A914I7E8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1106 effector family protein variant</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7E8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g732.t1">
        <property type="protein sequence ID" value="Gr19_v10_g732.t1"/>
        <property type="gene ID" value="Gr19_v10_g732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433019" evidence="2">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g732.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21081" checksum="702D95D6897FF3D5" modified="2023-02-22" version="1">MRTILFLAVVCLVLAALLETANSKPADKKAKKGKVSTPAKGKASLKAAIHTISKAAKGNKKANAKSPAKKDAKAKKEQKSKSKNAATKEKTANKAKSVSNPATKPKAAKSTPAKPKAIKTAEPKLKSLMPEPSSAPIVAERDANNFDMDNFNSIGAEHTEFDRDNDLSEEGELLDDDASAGGSSGDYSGIELDQDSQYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8Z2</accession>
    <name>A0A914I8Z2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8Z2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7814.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7814.t1"/>
        <property type="gene ID" value="Gr19_v10_g7814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7814.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="32500" checksum="47B35AA711C70F17" modified="2023-02-22" version="1">MNGHLTKWARKRKRKRKEERGGRGKGKGRERKREGEEEKEKEEKGRERGKRKGKGRERKREGEEEEEEEKEERGKRKRKRKRKRKRKEERGGRGKGKGRERKREGEEERKRKRKEERGGRGRGRGKGREGEEEEEKEKEKEEKGRERGKRKRKRKRKRKRKRKEERGKRKRKRKRKEERGGRGRGIGKGKGRERKRGGRGRGRGRGKGKGRNREGEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEKEKEGTERGKRKRKGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9V9</accession>
    <name>A0A914I9V9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9V9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8029.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8029.t1"/>
        <property type="gene ID" value="Gr19_v10_g8029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF77">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8029.t1"/>
        </source>
    </evidence>
    <sequence length="460" mass="50984" checksum="822B6DFD969A9496" modified="2023-02-22" version="1">MIEQTLEYSNQPTQSGNENVPIAIQQLCLTCKLIAVLSYSALSLIAFVGNALILAVFLRFKRLRTPTNMFIAKLAIGDLMVSVFCIPLSYWHVLVFEDQRWVFGAFLCKCFNYLQATAVFLSSWTLVAISFDRFIAIQFAMSPWLKMTRRRALYAILGTWLFSLGMALPLLVVNKLSHSSDGVETCLEQWEHFFSANYVHVQSVWLQYCLPLAVLLITYTAIGCKMWNSGKVPGGESYLPPRASNKLYDKESTTPTSGRYSKARESSICGTLTEGKSVKKLVPMVLLVSALYAVCWLPQNLLMNIFVTYDPAILSHPYILYIWWGSHSVAICHSSVKPFVYYVTNRPHSRSIEVGIWAGRKTDATKTGIGDQTEEIMLAGRNIGTLVGHLHNDCLGGAYINGTAEALYNGGLLGCQAPLRNVVGGGRPAICKANARHGLRDHAGPAPSKSIKERSIISDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAS2</accession>
    <name>A0A914IAS2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAS2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8242.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8242.t1"/>
        <property type="gene ID" value="Gr19_v10_g8242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="606"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="378"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8242.t1"/>
        </source>
    </evidence>
    <sequence length="706" mass="78452" checksum="DEE6F8D3D8919786" modified="2023-02-22" version="1">MDAVTSGTGEVQLQLEGNGAKDQTAAGPPKDETEGQPREKAQQQQQQQQSGGSGTALAKLDLLSREDLIKLAKKQLIVLKETRKQLATAKKESEEYATQMRELSTKMSADSSSFSSASEKGGGGGMMAMELADYKNALVAARKELAEGAAKTGEREAMVEELSQRIAQLQLEKEEVNSELRLKNTQNAELTQKMEENVRLLSEHAKEAGALQFRLNEASQSAQDELHTLQNEQRQLQADLAAVRRTADARGAEARRLRADSEMSAQLLAGLREEFAAYKERAECALAKFKEVADGGAISGGNSSSEFQQLIDALSTRNAQITELNAKCSFLEEELRSGHLHSKTLLDELNSLHDQQQTQRQQWAVERQRMVAEHAERMRAGETIRAELQKELQATRERETAAVALQQMEKVSGHKQQQTAVDELRRECDRLSRELEEAKSLLKSSVPPKHLSKPAPLNFGFQPQQFTTTTTATTNSLETDAEEEGAGVLGTTHSESSDSMDDLNSVLQEAADGAVSGGDLLTTFNVASLAEHFGGVRSDECDGSVSANLQQHFIGRDQHQEVLKLLEDCRELLNETEEDNVRLNEQVVVLKTEIRRMERCKKRVEHLGNGLCPEYFKNIVLKFLAPPKVRDERVQLLPVLQSILHLDAAELEQIRRNCIVQTTNGTLEGEEVPSETTTSTFVQHKEEDNDGWSSWVFFMRSFVHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAU5</accession>
    <name>A0A914IAU5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAU5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9109.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9109.t1"/>
        <property type="gene ID" value="Gr19_v10_g9109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00049">
        <property type="entry name" value="WILMSTUMOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9109.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="20416" checksum="722F57939357BE8A" modified="2023-02-22" version="1">MSVNVPLKQTLPFNLLPETNAMMSSTTVLISIVLIVLISAGPFVVQADNQIVGPVDESHELINRIKRNGYGYSGYGYGGSCSSCCSSCGGGGGGSSYQPTSYVQQAAPAPPPPPPPPPPPPPVQPVYTPVQPSYSSCNTCGGGGGSGGGGGGNGLSGYSSSWNNGGSSSNSWSSSGNSASSGGSGSSMSAGNGGGYGYGGGGCSVCGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBK6</accession>
    <name>A0A914IBK6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g933.t1">
        <property type="protein sequence ID" value="Gr19_v10_g933.t1"/>
        <property type="gene ID" value="Gr19_v10_g933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="1614"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="1614"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="757"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="888"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1151"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1224"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1466"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1654"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1289"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1302"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1499"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1523"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1540"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1654"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1675"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1714"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1728"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1749"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1759"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1785"/>
            <end position="1810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g933.t1"/>
        </source>
    </evidence>
    <sequence length="1810" mass="200768" checksum="9186A033F19EDC7A" modified="2023-02-22" version="1">MQAKGVMDATESTTARAKLQRRRLRLPRELIYELILRVPCTECDVRRLLITCSFIYQCEALKEADEAKFSKIMRRCFHSIIWSASITSCHYCRAQFSTVVSTTDQAHRQFYAIAALDPTLVNGPTAYFRRRCLRVAINNGFLGSFDTFYFLKNEAFRYDVVRFNFHFLTSNADLARNIHRVMMNLDEALCKAAAGEFDNLMQQVRGTNSEGANADELKPLENDQNRKEKLHLEVAKLRDELAQLTDVTKNNEQEQQLVVLKALELRLFNMYTFVKRVTFNKQFMENSSGWHQIIQQRSKIESMKRICKLSWHTSIAAMNPNNSRQCDQRLAQFQGYSQQQDDYFQSRPLANPQQQQQSWLPQQQFYMPYDQYPSIQQQQQYDPRMVVHMDDVHQQQQNYFVGSMQDDDGMVIGETCTVISSSPTFGLSPDMHLQQPFGGGQSAAAHIQSSSATAAAYDSYFEQAQYLGPSPTHHWSPHSSSMGLGSGQLYSQTQISPSHDFVRRTPTKTPFEEEEEEEEDEEVERANAQGSTSAAVDGAKRMMYSSKMPTKIMPDSKQQPLSRAVVEADKPKVRRRKQEFEKSAKVMMSSTASDPSPKRVIFETVGGMKVEVKYDEGFKKPAGKVKQLAAEEAPKNLVDKSLIVAQTTQRLGTVEGWRRMNGWLKSAIKQSDGIKLKQLLAQLLNANISVDLLRDEVDTPKLVKKLQKSDDKGIATMAMNLVNDWKQKVRSEKRAVKSVDSLPKLEPDKKAVLPAFHQTPSSSSAGSKGKQTAVKSDKTTTTPTTLAGSSNFESPLTRILSATDKFHAQNRAVQPKRKSVEVMFSDNFMDSLCGPSGEASATAPTKKPKIIRKKLSDLCGPSEEASSATGPTKKPKIIRKKLSEAVKRDSLEEKDGQQQLGGGQPAVGAFGNKKRVRFSDEFGIELAQTRFFEIEEGERVNVTKMHLSREEIKHFDSHREKITLHQHHSFGAFSLTDPMLMPPGHRLQQPQISPQQQHWGGAATSGYGQMAKFGKEETLYRWKMSPLDETFCLVVPGSKSQAKNIEATRIRGVMEAICLPEINLPISDMDENEYKQHQIETIDHVPKIIPLEMISEGVAAPASQAGLVTPRGENGADAGRLLEERGEEDKKGPDAEIKPKSGGDETVAAIAGRATTTPKLCAEPPEGDGLREYNERMEEDEEELEAPYSPEAPDFERLEDYEEEEDDEVTIIEHGVQRKAAAAFGGSVQKKAGVAETLGDSPEVAQCNASPVEHGPASPEPEPMDESTESVELKEIPTEAMDTDDEQEEAGKEDLDIREQFTSPTEDSTATAAAAEQQPAASSSPSATAEHQQQQKTAGAVAAGHHDLSKVQEFLRNGGVTASLLKRLSSMVGSHAGSGASSSTHRSQDQLSVVGEGTPKGMEVCSAPVTPYKTDQFVSSPIVPSGSPCPAVVSLAFNNTTSGNNNNNRFLLPQFAQSHIRALNSNTTTTNTGFPPPTFPQQHAIVGPTGGRVPFPDFSRPPPNFTSPPPQIRPPQFRIQTPVQQQHSSGESPTKSGAQTSDESSSAIASSTTNEEGKTTSPGPPGLDAGGSPPPPQTTTEQHAQQPPPQQQQQQHKELQPLLNEVEARALVGPCQFFMRHNTCKFGERCKFAHGEDSVTFGVQMAMRGVKIGVRGGARGRGGFIGRGGGFRSAGADDRRSSDEPGDSGRDFDDKRPRRRGTSGRYISPVRSSGDSRYDRRYRSSPDRHRRRRRSRTRSRSRDRYSRRSRDRRRKSRSRDRSHSRERSRSSRDRSRSSRDRARARSSSSSSSSSTRTYSSRSASPPANSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBS1</accession>
    <name>A0A914IBS1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914IBS1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8745.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8745.t1"/>
        <property type="gene ID" value="Gr19_v10_g8745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="213"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="391"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8745.t1"/>
        </source>
    </evidence>
    <sequence length="597" mass="67264" checksum="4F0E7E566F85B063" modified="2023-02-22" version="1">MMELASVSINKYAARRRKLLEEEAKEKVEVSSSGDSDLDSYIPVRQRKREQEHRRLLLKNIIHSSALTEAQADKALKRETEEILAQKRKKKEDEKKMEESKKSLLEKHNELLQQEQDDDREEVEKQMEEEDKILQSVTQTSALATVAEIAKGVKYTQSIRTSWKAPRHIRHQTHLDYDKFRRMKGIQIEGDDCPSAIGSFLEMKLPRPVIAGIPVALSGRDMIGIASTGSEIALRFKRGEGPYGLIIVPSRELAKQIYDVIIWVCGALPSPDYPELRVGLCIGGFPIRDQAREFERGVHIAVATPGRLSDMLNKKIFNLQVCRYLVLDEADRMLDMGFEEELRSIFSYFKGQRQTLLFSATMPKKIQNFAKSTLVKAVVVNVGRAGAASLNVTQEFEYTAPCVLIFAEKKADVDNIYEYLLLKGIEVASIHGGKDQKDRHTGVDAFRKGQKDVLVATDVASKGLDFENIQHVINYEMPEDIENYVHRIGRTGRSGRRGIATTFINRKADLSVLLDLKHLLIEAGQQLPAFLKQIAGEDEDLAPDHDTEPINEMDKGCSYCSGLGHRITNCPKLESVRTKNASNLLQKRADFGGQDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBU9</accession>
    <name>A0A914IBU9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBU9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8499.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8499.t1"/>
        <property type="gene ID" value="Gr19_v10_g8499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8499.t1"/>
        </source>
    </evidence>
    <sequence length="441" mass="48719" checksum="F414A87BD19224DB" modified="2023-02-22" version="1">MPTTGAAGQSGQPPKKRVQFKDDAILVQTRRYEPNPAEWTAFDAQSQPRRQMIRGGNNIRAEDRRRREKYAQKGEETAAIAAGWRLIGVDGAVERVEPGANSVSRAIETERCANTVGHFWQNRTSIPELQPLDDENGTTGADEWFCETMAIPLELVPAGNDAKQMQPTAAFVESAAGAIEVSGKDQPIESGTNHWSLDGGRNECQQLLSDIRALLDVPEMSAEETANALERCGTRSPREICAEMLRMLEAPLGSEVSDDEHSKEKQPVDGEKTAPVATNASEMNSDILHPSEAEEASEEATNLVVYVRREVEAVQQAEKEEETRENDAKEDQNGEKDDDEEEEEDEEEEDEEEEEESVLPPGLFDDTSSGEENADEVGQKWPSPKLPRPAIGFGLHPCGFKVALEGIEPLTKRFQIALVRRDLIIKAEQKNSKSGKKSAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICA5</accession>
    <name>A0A914ICA5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICA5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9504.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9504.t1"/>
        <property type="gene ID" value="Gr19_v10_g9504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF1">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9504.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26575" checksum="66C71D6F2EFBB694" modified="2023-02-22" version="1">MAPAGDTVMGRTISIFILYVWNIRMSTPLINKPFGDQSDRRMEQGRKGDNGKGFPTDRIPGKAIIFNPWAAAVVTCVLNPISAVTLITAVGIGVEFTAHVALAFLTSLGTREERMVQCLQHMFVPVIHGGMSTLLGIIMLAFSDFDFVVKAPRHFRIWTAQRHKGCHTSCKEWDRANQSKSASPQTVVTFTNTTPPMAGGSTRKFYALVISFLYICFALCDIYSTAGPPFYQGFKLRQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICS5</accession>
    <name>A0A914ICS5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICS5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9645.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9645.t1"/>
        <property type="gene ID" value="Gr19_v10_g9645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9645.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40391" checksum="71217DEA831606A0" modified="2023-02-22" version="1">MDSSLFFTAMAVLANADLFPFLFALVIGIPSAALYCLELSVIITNFARFSSPFFVLVAVRTISGLASYVNAFFAHRFGKIGLFLSVYLQLPRIVLAFLQFVVYYSFHVENLLTAFLLLHRCTAILCPIKYKTFWRRRSTLLIAVAFVLPLPFTVPIFNLDMFVHVQRDNVTFTLDDHKTENELNSTEIAAWSAVIFGIVCLLLNVATLFAYKMRAHSQQPIDKNKRKITIYTVATFFGQLIMAIFMIFVYLTATNFLDDQNNRYSLLQKWFGITLEQNDILFLANFNQYPWVNDLATVVIPAWLLLWASNKMREILVKKIKFIHFFERHAVGVPVTNVVSVTVIRQRPIASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDU2</accession>
    <name>A0A914IDU2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDU2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8967.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8967.t1"/>
        <property type="gene ID" value="Gr19_v10_g8967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031098">
        <property type="entry name" value="Crust_neurohorm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037954137" evidence="3">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR631098-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8967.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15931" checksum="F1A495B05D01FBF7" modified="2023-02-22" version="1">MLFLHFKTILLSSVTVVLLTAMRTFGEEDERINDSIGGPMALVVQEGVDEDDTGRHVPSTDDASNGHKYCEIHDNEPLHALMDQICELCHDLFSHVRPNTRVQCRAECFLTATFKKCLQLFIMPNRSRRREQMQLVMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDZ9</accession>
    <name>A0A914IDZ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP synthase F0 subunit 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDZ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9016.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9016.t2"/>
        <property type="gene ID" value="Gr19_v10_g9016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9016.t2"/>
        </source>
    </evidence>
    <sequence length="114" mass="13090" checksum="6D7ACEE92CA06D3D" modified="2023-02-22" version="1">MYGVKRVSANNLETFFFILFLLIFAVAAAAYLWVKGTEDEERSRYKLFLECVLILTSVIPPELPIELSLARNIRSIFQSGVPRLLWQQDRVKSPAIHDMLMIKRDVRPLPSPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IH16</accession>
    <name>A0A914IH16_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IH16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9836.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9836.t1"/>
        <property type="gene ID" value="Gr19_v10_g9836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036827274" evidence="2">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9836.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11110" checksum="61DB55F56FF6E373" modified="2023-02-22" version="1">MKVSVNSISLAIALLLALELTFNGINAHDNDFKATDNDFKANDDKNHDNDNKAHDNDNKAHDNDNKAHDNDDYTNYSAHNYNSTIFFRLSFWTYLSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D1FNK8</accession>
    <name>CL4A3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName>CLAVATA3/ESR (CLE)-related protein 4A-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CLE-4A-3</name>
    </gene>
    <organism>
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Mol. Plant Microbe Interact." volume="22" first="1128" last="1142">
            <title>Structural and functional diversity of CLAVATA3/ESR (CLE)-like genes from the potato cyst nematode Globodera rostochiensis.</title>
            <authorList>
                <person name="Lu S.-W."/>
                <person name="Chen S."/>
                <person name="Wang J."/>
                <person name="Yu H."/>
                <person name="Chronis D."/>
                <person name="Mitchum M.G."/>
                <person name="Wang X."/>
            </authorList>
            <dbReference type="PubMed" id="19656047"/>
            <dbReference type="DOI" id="10.1094/MPMI-22-9-1128"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Mimics host plant CLE extracellular signal peptides that regulate cell fate. May play a role in the differentiation or division of feeding cells (syncytia) induced in plant roots during infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host extracellular space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cell apoplast</location>
        </subcellularLocation>
        <text evidence="1">Present in secretory granules within the dorsal esophageal gland secretory cell and in the dorsal gland ampulla (collecting reservoir) at the base of the nematode stylet. Secreted into host root cells via the nematode stylet to transform the recipient cells into enlarged multinucleate feeding cells called giant-cells or syncytia. Secreted to the host apoplasm from its cytoplasm via a plant secretory pathway (By similarity).</text>
    </comment>
    <comment type="tissue specificity">
        <text evidence="5">Highly expressed exclusively within the dorsal esophageal gland cell during syncytium formation in host plants.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="5">Strongly up-regulated during root colonization, from the onset of syncytium formation by parasitic second-stage juveniles (pJ2) through the J3?J4 molts of sedentary life stages that become adult females.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CLV3/ESR signal peptide family.</text>
    </comment>
    <dbReference type="EMBL" id="EU386833">
        <property type="protein sequence ID" value="ACY70452.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EU386840">
        <property type="protein sequence ID" value="ACY70459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1FNK8"/>
    <dbReference type="GlyCosmos" id="D1FNK8">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043655">
        <property type="term" value="C:host extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044962">
        <property type="entry name" value="CLV3/ESR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36349">
        <property type="entry name" value="PROTEIN CLAVATA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36349:SF2">
        <property type="entry name" value="PROTEIN CLAVATA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0221">Differentiation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5000539268" description="CLAVATA3/ESR (CLE)-related protein 4A-3" evidence="2">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="A-1">
        <location>
            <begin position="127"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="CLE-1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="A-2">
        <location>
            <begin position="148"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="CLE-2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="A-3">
        <location>
            <begin position="169"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="CLE-3">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="A-4">
        <location>
            <begin position="190"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="CLE-4">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for secretion from the host cytoplasm to the host apoplasm" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="4 X approximate repeat A">
        <location>
            <begin position="127"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="4 X approximate repeat CLE">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="19656047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="210" mass="22939" checksum="EEFFD54CF66FFE3D" modified="2010-01-19" version="1" precursor="true">MAKNAMLCLLILRVVLALAFATNKKGDEEPENHSTGIFGKVGRVVTVALAMSSRLGGADATRGGGAVYGGNLKSNQLPNNNWMAPPPPMAIRSAKVYDSKHSPAEYLKKFAQDFRRKTGMHSQRHHEETTLEQEKRVAGAGPDPIHHQDTTLEQEKRAVPAGPDPKHHEETTLEQEKRAVPAGPDPKHHEDTTLEQEKRGAPAGPDPIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>O77094</accession>
    <name>O77094_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8 10">Beta-1,4-endoglucanase</fullName>
            <ecNumber evidence="8">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eng-2</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="1998-03" db="EMBL/GenBank/DDBJ databases">
            <title>Genomic sequence of the potato cyst nematode cellulase GR-eng-2.</title>
            <authorList>
                <person name="Smant G."/>
                <person name="Yan Y."/>
                <person name="Qin L."/>
                <person name="Stokkermans J.W.P.G."/>
                <person name="Wang X."/>
                <person name="Hussey R.S."/>
                <person name="Bakker J."/>
                <person name="Helder J."/>
                <person name="Davis E.L."/>
                <person name="Schots A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Ro1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="8"/>
    <dbReference type="EMBL" id="AF056111">
        <property type="protein sequence ID" value="AAC63989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O77094"/>
    <dbReference type="SMR" id="O77094"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="ABCD" id="O77094">
        <property type="antibodies" value="1 sequenced antibody"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g5544.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5544.t1"/>
        <property type="gene ID" value="Gr19_v10_g5544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038330149" evidence="6">
        <location>
            <begin position="23"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="44"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC63989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5544.t1"/>
        </source>
    </evidence>
    <sequence length="391" mass="41951" checksum="0145DE651162E50B" modified="1998-11-01" version="1">MCRLQFLFFRVFLLHALHIVFCNALTATPPPYGQLSVSGTKLVGSNGQPVQLIGNSLFWHQFQGQYWNADTVKALKCNWNANVVRAAVGVDLERGYMSDPTSAYNLAVAVIEAAISQGMYVIVDWHSHEAHADKAVEFFTKIAKAYGSYPHVLYETFNEPLQGVSWTNILVPYHKKVIAAIRALDAKNVIILGTPTWCQDVDLASQNPIKEYKNLMYTFHFYASTHFVNGLGAKLQTAINNGLPIFVTEYGTCAADGNGNIDTNSISSWWTLLDNLKISYLNWAISDKSESCSALKPGTPAANVGVSSAWTTSGNLVAAHDKKKSTGVSCNGATPARGSSSANSGKPAAAKKPPAKPAAAKKPPAKPAAAKKPPAKSAKAAPAKKPKSKSG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>P53023</accession>
    <name>MSP3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName>Major sperm protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MSP-3</name>
    </gene>
    <organism>
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1993-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Novitski C.E."/>
                <person name="Brown S."/>
                <person name="Chen R."/>
                <person name="Corner A.S."/>
                <person name="Atkinson H.J."/>
                <person name="McPherson M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Ro1 / Mierenbos</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Pseudopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text>Sperm.</text>
    </comment>
    <dbReference type="EMBL" id="L24501">
        <property type="protein sequence ID" value="AAA29148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P53023"/>
    <dbReference type="SMR" id="P53023"/>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051155">
        <property type="entry name" value="Nematode_MSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22920">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22920:SF7">
        <property type="entry name" value="MSP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0966">Cell projection</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000213456" description="Major sperm protein 3">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00132"/>
        </source>
    </evidence>
    <sequence length="126" mass="13975" checksum="0255C5CF3335B9F1" modified="2007-01-23" version="2">MAQLPPEDIATMPAQKVVFNAPFDNKATYYVRIINPGTKRIGFAFKTTKPKRINMNPPNGVLGPKESVNVAISCDAFDPSSEDSKGDRVTVEWCNTPDPAAAAFKLEWFQGDGMVRRKNLPIEYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GNZ8</accession>
    <name>A0A914GNZ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GNZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10010.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10010.t1"/>
        <property type="gene ID" value="Gr19_v10_g10010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10010.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37938" checksum="35EF7F64FC373842" modified="2023-02-22" version="1">MGGENVKTEERKNVAGKHDTRKCDAENATPKNATPENADTKVENATPMWKMRHRKCDIKVGNATPENATPRWEMRHRKMRHQGGKCDTKVKNATPRTVTSTVSFTPNERQKPIPNPGQKPFPQSAKKAQFCLRARALARLCDDYRNSLNEVRSGQYRMNWTPNITIIRIARIVQSGEQAPPPFVASVLYEITAARPVPPMDPQRPLGPLLQMPQLKRRRHRARRPWFLEFCCRRRRAANNLLPSATTTATTATNATPPPPPPPPPTPHRHHRQHRSRRQQQQLLKQRQPPAKKRSDDTWSEDDIKPMPLIAAPRRRLVIESDEDEDAKMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPI1</accession>
    <name>A0A914GPI1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPI1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10224.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10224.t1"/>
        <property type="gene ID" value="Gr19_v10_g10224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10224.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16865" checksum="E2C7F6175072CFAB" modified="2023-02-22" version="1">MESYFSQNFVWNFMGGKIDCKWKMSYSDDDKKFSCCHRLTLHECTRAPARRPFVQDDPLNKSTLMKVNAECKDLVDDQCPCGWGSCFPREGRAAGECCNKHHDLVCCEGNRRLELNGSNTKAKISKVFLMLLVMRLAVGRILAEMATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQR8</accession>
    <name>A0A914GQR8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQR8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10454.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10454.t1"/>
        <property type="gene ID" value="Gr19_v10_g10454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10454.t1"/>
        </source>
    </evidence>
    <sequence length="884" mass="99213" checksum="1F15E38337850A71" modified="2023-02-22" version="1">MCPPSSVRNVCIIAHVDHGKTTLADFLVSANGVISARLAGKLRYMDCREDEQMRGITMKSSSISLFYEPLLLNLIDSPGHVDFVAEVSSAVNLADIAILVVDVVEGVCSQTESLIRQALSRKLDILLVVNKLDRLVRLLESVNSCLSQAIHGQLLEEDWNTFEQMENQLHFDSSKGNVLFASALYGYAFAAEDFAELWAKRIIGPKCEGKEPSNDQLKRTKKQLNDNLFSSDHFFSANSKQICSGAEQRGKKPLLEQFVLEPLWELHRCALVEEDLEKLRQMSAKLSLPLLKGRRAEEAFTEMMRQWLPLSSAVVRACARMRSAQKAFQADDRIGQLFSSECEVDELTLVFCAKAFKLESHRVSLCRVMSGTLKIGDQLNVLRSSANSKSLVPGDAWHSVQIVRSRWSNLRDRGIRWALDWRANAELESVARHRVTVRPTNAGMDELNELRSALKQLSVLDSAVRVLEQEDGDLAMLTAGEVHLQKCLEDLKLLGQTEIVVSEPIVPFLETLIPDPRLSYAKIISGHKTECFLRQFSLRMTLRAVPLHDQIVQMITQNEKLIDSIIEGVSDPDSRHKLDAFQSQLSLCACNCLPKMKGSWWAKHSIAEIRRLFSRIWAFGPSRAQSNIFFNGCPNGQDENPISVWKGNLSSLDQAVVAGFHLAMSHGPLCDEPMQNIGIVLEEWEEDETEGNGISEGTERGETTQKCEDANSLVGGAQLQGQLISAIRQTCRVALKKHIGSLRLLAALYRCAVQTPTQSLGKVQAVLAQKRAKMLSEEFNELTGLFEVVAHLPVIESFHFCEDLRKRTSGTASAQLEFSCWQLIEEDPFWQPTTEEEVEEFGNRGFEKNQARLYVDTVRRRKGLPVEEVIVVSAEKQRNLKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRJ5</accession>
    <name>A0A914GRJ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRJ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10091.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10091.t1"/>
        <property type="gene ID" value="Gr19_v10_g10091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10091.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17338" checksum="18FDB09729E38A13" modified="2023-02-22" version="1">MTKIGAAKFFAAGEIRADKGRPAGKWHGANSATVGWSSPKINFDFLREHSVPTAHRNELKLETDGRAKQSTQIICPNYLCLPPSSNLSDLLTAPLMDSHAANKSVKFEYYAGTRQFNANSIQQFSATIFRRVIGYLFLTTLNIAQERPKVFEITSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRS5</accession>
    <name>A0A914GRS5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF155 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GRS5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10702.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10702.t2"/>
        <property type="gene ID" value="Gr19_v10_g10702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="288"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10702.t2"/>
        </source>
    </evidence>
    <sequence length="851" mass="96820" checksum="C758AB8BB21DC45F" modified="2023-02-22" version="1">MGIDLVAAEKEQNWTGRRRITNLMDTTFVMTPRKWWGDAIIHEIIYWSAFVGDDARGVKTIAEGKGAEGGSESCTRTEGSHSAVEKGRVQPRPSAWLCPNPTPSSTNNILLCCPFPPGVLRTRKKGEGVLGDGQSAHRVRPNPLVFSYADDDGSSILRILEPAGNTMLMISVKRISLGGCRFALLRSKWRQCVTCFIKIDTVQQKTNRNRRKRPLTMLFKHKQNTATTTLPEVNCVPVAECFDIDAMCKDAKFTNFFTFNYVDDNKIAVYCRQKVFKMREAKVYGDFFVFAEGVVVFWDVGRRSQAFIGNILSKYQHNPFGDQLKKDEEETMAIDFTSGSSYASNDVVFLNSERHHRQLNAGESAGSSNSEWAFGSKRLMKLDDKVQGCIDGMKNRNDRWWRFLKRNGIPWDHKKALQMIGCFADLRHTVNSTDLLSKDVYWDLPEIESAYGSLARRLCLQSRRNWVNERLGHCEYFSKTISEALNTEHSHFLEVVIILLIAFECAHVATNWLGLGGQEVRAKVVHRAHQNGHEVNDVLMEDVEEAGEGTSAQQQTFGSDQNRRLAFIQTTARIKEELRKAEQGQTSGQTIEKLFEQVHRSNVDIDNVDNFRTLCRGSEALDQLIQLSVSQVEGMKDETAHSFDPGKLVARLKSFAIAHRKTEDKDHFTTIGRHFNFLLRKTPNFSYLRPCYEMKADGPHLREKTQRKRTTQPVKEETQIVQGKTLTEMGEAAAAASTADDGTGGSSTAVNKELDNVRRHLKRVYKQNGTDAVDYYRFVLHPNSFGETVRLRVDPCTGLASIVKLSHEEREERRCVERSKTQTVPRLDYDTWRRMVCELKIDKPYITRRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS75</accession>
    <name>A0A914GS75_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GS75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10715.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10715.t2"/>
        <property type="gene ID" value="Gr19_v10_g10715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF341">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="201"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10715.t2"/>
        </source>
    </evidence>
    <sequence length="287" mass="32437" checksum="C4822413A5CF4E8E" modified="2023-02-22" version="1">MTPAELEQFDCAAASGVFRPLLIGKTGGEISFIDDEDEDGDSIERLPPSPSSTSPSRPPPNGPISPLTIRRTVSLLPTLSRPIEKRARKTTVFKISLATVADDGIKYANRRKRPWLQPNLTKFAVENNYLRTKSSLVERNLVDTNGEPRMISKLQKTTKFWPYEIWRDKFLREHNCWKEELCREVFLSALPHFVVLLVVSIYILLGSLIFRRLDEQLDKLPFHDVLLFTFTTITTIGYGNIAPRTPQARLACVAYCLVGIPLVFLPLSNLGEVLAEFYWIGIASMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSK5</accession>
    <name>A0A914GSK5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">VQ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSK5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10990.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10990.t1"/>
        <property type="gene ID" value="Gr19_v10_g10990"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6828.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6828.t1"/>
        <property type="gene ID" value="Gr19_v10_g6828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041109640" evidence="2">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10990.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6828.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18181" checksum="15A04C5C7FC9BA87" modified="2023-02-22" version="1">MRRPVIVLVLLAILGLFACCAGAPKEEKRKRAKLLPRPQSIFLNPNSTDFREVVQRHTGRESINFDQSHPGMSNVPQMISFDQSHHPNPNMSNMPTTWTNPADSANMLNFESQQYHPAGNTQWTNPAGNTQWTNTAGNTQSTNPGGRNFFYNPFKQKHPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU36</accession>
    <name>A0A914GU36_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GU36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10782.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10782.t1"/>
        <property type="gene ID" value="Gr19_v10_g10782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046662">
        <property type="term" value="P:regulation of egg-laying behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19032">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000038">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000023">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="77"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="199"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="407"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10782.t1"/>
        </source>
    </evidence>
    <sequence length="715" mass="82975" checksum="DBF89EF52FAE305D" modified="2023-02-22" version="1">MFYFSIFGRRQRRRRVPRLLVAAFAVAQSIAAAAINATLAHGRQFVDDRRRHGTRKSSNLRTDHRNGFIIIFKKLIKSQKFHMDEQRMSKKLRLTIESIAFIAEHIKAEMSDKKVRDDWRFISMVVDRVLLLLFFGITLGGTIGILFSVPHVFELVDQQDILRRLSPIFELCQSDWAKRLPQGCYRNTKFNSVISSEVEERLIADLFRGYNHLIRPVPNVSSTPLEIRFSLALTLLINVDEKNQIMQTNVWPTMRWVDYQMQWNPLEYGNIRTIRVPPDKVWLPDIVLFNNADGNYEVSFYSNVVVEHNGEMLWVPPAIYKSSCIIDVEFFPFDEQICAMIFGSWTFNKDEVVISYLNNKRQAELNDYSESGIWDIMEVPGQLIHQKSKIAYQIRIRRKTLFYTVILIIPTVLMAFLSMLVFYLPAEADEKITLAISILLALVVFLLLVSKILPPTSDTIPLIAKYLLMTFVMNIITILVTVIIINIYFRGPTTHTMPEWVRTVFLRYLPLFLMMNRPRRDSLEDPVGINRPGAHKSRPSAKTKKRQSVGRNSINSFLATTEDGIELGERARSQRQLRFMPGQFIEMSHSRRERRVDHLRRRRMSQPAITPARFPTHRDLGSDLSDMLTDQALQALDAVEYITEHLRRDNLDKKIREQWKFVAMVIDRLLLYVFFGVTAGGTMGILFSAPNVFEYVNQTAVIEELKRTAEAEMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUD2</accession>
    <name>A0A914GUD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger RING-H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10868.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10868.t1"/>
        <property type="gene ID" value="Gr19_v10_g10868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47662">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47662:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10868.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22698" checksum="68C4E922593C80AA" modified="2023-02-22" version="1">MVHHHKLLYHLISLNPATSYVYETKMDACTRHRLFPNSSIKVSLSETDDYGPPKSLACADVFHTKCIDKWLQTKSECPVCRKVVLPNELETNPHIHNGVQEPVRQNTGGTTTGGSRPFNAFPSENEEWEPHDDLLWEPHEYLLNEQSGQQTHGQNDQTASAVDLAKNIGVTTGRVLARGLTMLGNSLNDWLDGDENSQHGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVQ8</accession>
    <name>A0A914GVQ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVQ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11782.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11782.t1"/>
        <property type="gene ID" value="Gr19_v10_g11782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11782.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21507" checksum="99F3F2ED9C63D52D" modified="2023-02-22" version="1">MPHKSRTALSAQPVRMPSPECRRPNAVTRCRRPNAVTRCRRPNAVAEGALEMYSADEALLLKQCSDLVVGAVLPSRLATVSFWHPCDCEEDGTVAVCPPSQMALQLATLRPRTALRMPSGQLFLQPQQISSLNVVSPLPAGDKELMNCWLVGGHENRSQCVRASARVTRGRERAPADLCSSNTNQHAFGEEAAAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXI8</accession>
    <name>A0A914GXI8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L4 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12113.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12113.t1"/>
        <property type="gene ID" value="Gr19_v10_g12113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="4">
        <location>
            <begin position="274"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12113.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38812" checksum="5F58A0CB4D3B1DF5" modified="2023-02-22" version="1">MASRPLVSVYNEKNEPTGKQVKLPAVFRAPIRPDIVSFIHDQIRKNKRQAFAVSTAAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKVYRRWHRKVNVAQRRYAIVSAIAASAVPALVQARGHAIDQLSEIPLVVSDKIESFTKTKEAVGFFQRAHLWDDIEKVYKSKRYRAGKGKGRNRRYKQKLGPLVIYKNDGGIVRAFRNIPGVTLLSVSHLNLLKIAPGGHLGRLIVWTESAFNALDSIFGTLTRKSSVKKGFTMPRAKMTNSDFARIIRSDEIAKVVRPVKKLKKVAKIHGNPLKKHSLMAKLNPYASVLRRAAVLASSKGQPEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXL9</accession>
    <name>A0A914GXL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Troponin I</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11328.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11328.t1"/>
        <property type="gene ID" value="Gr19_v10_g11328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF41">
        <property type="entry name" value="TROPONIN I 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11328.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28803" checksum="840C2A30D32145EC" modified="2023-02-22" version="1">MGNLRRCNWRIEHNELAYYCDKQCLHFAEIAKMELNSSSALLVRGLTGDEETELVLKAERERKKAEVRKRLEEAGRAKKAKKGFLTPERKKKLRKLLMLKATEDLKLQQQQRAEERQKVLNDRIPLVPDNFEMMSEDQLLVLGEQFRQRILSLEDAVYDLSYTIRQKDFEINELTIAVNDLRGKFVKPTLKRISKMDSQFDKIKKQNAAKVDYRSTLKNIGRDGSKFSMIEEDSSRADTSKAEWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY72</accession>
    <name>A0A914GY72_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GY72"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11876.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11876.t1"/>
        <property type="gene ID" value="Gr19_v10_g11876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14993">
        <property type="entry name" value="7tmA_CCKR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="134"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11876.t1"/>
        </source>
    </evidence>
    <sequence length="482" mass="54289" checksum="BBA746FEE91D475E" modified="2023-02-22" version="1">MATELPDGLTFVIAATVYFGASARPAHVVNYIMPGTRKCRAEVGLKTRHASPEPEFSMNKSTTIPPPVFLLPSFDDITPTMQIEIAGGYSGDEELDRLNDDEYVDFVADFLRPTPIEWIFVAIFAVLMAVGVCGNCLVVYVVSRNRHMWTSMNLFLTNLALSDLLVLVFCLPPTVLNDITKTFWLSSEFCKAMLFIQNTSVYVSVLTLVAISAERWKAISKPLSRALPFRRTCQMILLIWAVAGLLSLPEPFTLRIYPAEYARNLTTTWGTRCKESWSPEFQQKYQLIQTVALFLAPLTVISALCVHMGVVLRKKALQIGSRHLRDRQRAMRMLVMVVFVFAISYMPVHLHNIATAFQQPDQWADDGSQPSLVMIALRKFVPRLMSYSSSVINPITYNFMSEKFRKEFRRACRLDDAGGAYSKKSLENWSTMGGTAQRSPASYFRQAPTAPAAVAPAWRQRQPLQHALMRKCTSLSIHSAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0U7</accession>
    <name>A0A914H0U7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0U7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12200.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12200.t1"/>
        <property type="gene ID" value="Gr19_v10_g12200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048634">
        <property type="entry name" value="SecD_SecF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF108">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="301"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12200.t1"/>
        </source>
    </evidence>
    <sequence length="940" mass="103666" checksum="56ACE47FFC23DC96" modified="2023-02-22" version="1">MHKVPSCPLLVVLPPGASVPGGAPSVTLRRPSSSLFVLHRRSSLIFSRMFDSTNARWGLFIAAHPVAHILISLFLVSVLSVHLINLRIEYDIRASFSPKNSKAMREESVYEQFFNLSTSPLRSFVLFSARDGGSMLRETHLREVLSLDAEVNEQMERRDSLTGMRGCDPLCSLNGPFHVVANALLAPNRSHQAANSTPLALNYPIATYLGTELFLGGHVLGVQTSNHSFTNNNSRIVSAKKIILWYFNRADTVETKMRLRKLTLKLFNEAQVEGDRLRSVKFEVFGDDIANSEMIRGAIQATILMSIGFVLLLLFVTLVIFRLLATSAVPLLSVLCVVLISILCPLLSSLAAFGLCTWMGNPLYTIMCVTPFLIAGVGVDDAFIMLQSWQHHQTIECPRRRLSFVMVHVGPSITITSLTNTIAFGIGFFTPTPQMSLFCLCTSIAVFIDYLLTFTLLCPVVVLLSSPPPAGHVHLQLNLHRRPLASSDKFPSPPLPAPPALVPPSPPSWVHRYALFLHSANGRMMALFVAAILYTIGISGVLRLKSSFEPSKAFPSDSPLSSSMNSLSEVFEEFFPVHVFVNHPPNISNTSEYAEFNAMVAQLEALPESWGARRTLLWLRHFEQFDRRADHFWRSMGFGRHQKYRPSYANLAFFVDQLGNPPIIKTETAPDGSLNVVAFQFTIVTRHMTEWWNRAVVEEKVRAILERFPQFNATMHDGDAAILNMLLTVKSDLIGSIAVTIVSMAVICSLFIYSRLGVCAIALCISSICFTLVGVLSWCGADLDPVTMVDVLLATGFSVDYTAHVAHQYHTKKGTSIDRIAHSLHEMCPPMLQAGISTALCMLPLAFVPTYAIVAFAKTIFAVILIGLLHGLFLLPVFLCALHKDKRKRKTHGGGELNAEKGEEEEEQLRKDDMLEEDGEKGARSVGEGGGGTTDAKNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4N6</accession>
    <name>A0A914H4N6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4N6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14126.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14126.t1"/>
        <property type="gene ID" value="Gr19_v10_g14126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038000041" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14126.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11169" checksum="8F74B3ADC1F01457" modified="2023-02-22" version="1">MSLLHVAFLAFLHVGMLLVAFSLRHFSEEARNSPKVDSLMVRLADGRLADADGRLADADSPTVQLADGCSLMVRLADGRLADNSSFREKIAAIMKNWGPDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4R2</accession>
    <name>A0A914H4R2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4R2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13229.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13229.t1"/>
        <property type="gene ID" value="Gr19_v10_g13229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13229.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16965" checksum="754540A3D4D18FF8" modified="2023-02-22" version="1">MTASLLWCSNLPVSPTYPLPSPPASRSSFFQQSQHRIIALISPLLFLEWMRLRIDQLTKRVPWRGVGEKFKNLRKTERKTKSLHILNCISCDAFDPSTEDTKATVVSWNGQETIEIYLSFIGRQRSSVGRAPNRTLEDSGAFPGVVCWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5L6</accession>
    <name>A0A914H5L6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13888.t4">
        <property type="protein sequence ID" value="Gr19_v10_g13888.t4"/>
        <property type="gene ID" value="Gr19_v10_g13888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037986766" evidence="11">
        <location>
            <begin position="22"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="202"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="675"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="708"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="741"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="774"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="807"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="14">
        <location>
            <begin position="879"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="13">
        <location>
            <begin position="1524"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="963"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13888.t4"/>
        </source>
    </evidence>
    <sequence length="1619" mass="179216" checksum="D32AF8F575FC0976" modified="2023-02-22" version="1">MWVWVVVVLLELLLLPLRMRCAIYGQKVPAREGSGTALFGGIGTAPVACGEDRLAAGLAAAAGSICIFTYARHRRRRCFCGFCGFCCCTSSIDARCEHWSSSARLGGVRFKHFGLLLDTHQTAPCPLSHNNQLICSAGNRTSTSALGYQPNYSHYYYHKKLDIARQNSDQRAPSPLRHRSDAFGWPPFKRSLASPPEGFKHYAIEEEIGSGQFAVVRRVRHIASSALYAAKFIKKFRGQHCRRGVLKAHIEREVDILRSVSGHDGVIELVELFENASEVVLVLEYVSGGELFEHVCQHEYLTESEAAQFLFQILRAVQHLHRLHIAHLDLKPENIILREQGEHFVKLIDFGLSRKLLPGSCVREMIGTPEFVAPEIINFEPLQLATDIWALGVVTFILLSGSSPFLGKTRDQTFANITAVNYQYPHGHPISELAKDFIARLLVRDVKRRATVDECLRHEWIRRHVQPQQQNIFHHPMIILSKQKQNGHHLVHICSSNSRAIRSRWKKFYAAVTWCLAYLQGIDGREASVHFKRGFKMNDNSISSAIFIACERGALAQLKQLVHGCRIQLDNVFNELGESPLHVACGNGFQELVAFLIELGADPALEDGRGDTALIWAARNGHAHLFNTFILSPVLINATNSIGETALHLATRYAQGQAVLSLLERGADPQLQDKHGETPLHIAAWDGQSGLLDLLCRFCVELNFTNLEGDSALHVAASRGHLECVESLVENGANLDEPNQNGQVALHLALSRGHVEIALLLLSRGCKPNVQDRVGDTPLHIAAERGLSAAAQTLCQLGIPVDVQNAKGFSALHLAARHGHIDIVRCLCLSGASVHLKSNDGMTAEIMALAQEQKQIATLLAKVRPEKARIKLVKQLSTMEGPLRRIKLKVFGHPGAGKTRLVQALQRSSASSLNSLMESVSRRFSDNLFPANSVVVNSSSADPIPPPLSAAINGGSATIIMASPSKSGENADSSADEGIHSGVPSSSSTTSSSSTNGIGHRHKTWPCAERGSAGRGPTQGIDIQNVAFPECGEFSVWDFSGHEPFHICYDHFVGNTDCVHLVVTRCSDDPTDEYKELLYWLNFLKGRVTPSEPIGHCGQIARRSVVAIAGTFMGGDCPITRNEAEAMMRTLKMRFETHFDIHGQLFLVDLSAQVDCAGSRELRTFLARQRDAILMRLQRPLRMLDETMAFMDQLREQYAQFPCITWPYFTTLIRSEVNPLASDGHCRQLIQQLQLIGEVVYLRDEGSEIDFIVLSPDWLGTHLLGTLFSPRFAHSPRASGRFSLEDFGAVFPEVTDPADMLQILETLQLCCVADTDFEFTVFISAAAPQDVWLPNRPRFVYGGLRIKPARGMEQTMQSIFPRIQVALRRSMQDFQDPIEADLAQWRYCSKMLSGKMEALIRLVGEAVEIQIRGPPEMATSCIYYLEDLANLVEQTGAEVAPGVSTERHFLSPAHLREHKTSPAMFTPETIMEMQQNESLIIVNSEGEEEEFTDVVCFGSKEAAGLLTLGVDISVSQLQLSARSELAALLDAPNTLGMDWSIMAVKLNLTEQIPEVDSSGQSLSRTDQLLTEWALHSPDSASVGKLASILQEMGRNDVKELLFRRVPLYLFSPVEQPNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5V4</accession>
    <name>A0A914H5V4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione synthetase</fullName>
            <shortName evidence="1">GSH-S</shortName>
            <ecNumber evidence="1">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914H5V4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14276.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14276.t1"/>
        <property type="gene ID" value="Gr19_v10_g14276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036880307" description="Glutathione synthetase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14276.t1"/>
        </source>
    </evidence>
    <sequence length="521" mass="58783" checksum="147722301FC3865E" modified="2023-02-22" version="1">MIKINGSSFIIVFMLTSFRGSAVSHNHVAIEGTKEAMQDYVENVTKNKMELRELSQFAIEWSHNHALIVRTSWKKDPDYSTDVAEFASVTLLPSPFPRKAFSQTLAVQTAMNLLYFRIANDYDFLMDAYKDVVKSDKHIRALVSIIKDVHEEGIKQPYTVMIQRADYMLNVIDNNDYEVKQVEVNCGSIVSLALDRKITELHRAMLKKVGMDASDRFVPVNKPDEEFINVLYMAWKQYGDPNAIVVILTFITHSPYKFDYANIELELARVSDGQIKVEYLSLKEGEKLSLDPETFTLRLNGRVVAVVNSGTSALGYLANEAAMETRRTIERSNAIKAPSLAIAISSSKKIQQLLANPGVLERFFPHSEDAQTVAAIRKTFAGLWGLEHDDQQTQKIIKDAIENPSNYVLKPNRDCGGYNFFDEDVAKKLTEFTPDERAAHILMQRLHPMQFKNYFLRPFNELTLNVVTGELGVYGFLMGNMLDGTVLHNVQQGHLLRTKLAHVNEGGVIEGAGVGDTPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5Y3</accession>
    <name>A0A914H5Y3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5Y3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14295.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14295.t1"/>
        <property type="gene ID" value="Gr19_v10_g14295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036695927" evidence="1">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14295.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23227" checksum="33CF44D91D861E79" modified="2023-02-22" version="1">MRPFLFLGAVCLLVADASPAEIDITPVLTLQNQWVLAADNKDLTLSALSGDVPLVVEHTGNNCGVRSVRAKESIPNEKSGIFYFEVEILAFTGSITMGLARSKLKWYQNVENQGYAYDSSGYITGIDFNEKHAFIVRNKIVGETFVGCGVNLATRQIFYTKNGELLGTVELSDDVKVHELFPAVSMQSNGSKIEANFGSKEFKFDFANVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5Z7</accession>
    <name>A0A914H5Z7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. PHYHD1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5Z7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14498.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14498.t1"/>
        <property type="gene ID" value="Gr19_v10_g14498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14498.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31501" checksum="26495B99EB141D80" modified="2023-02-22" version="1">MDSIVEEFDPEKHPRTTFNTSDEEKHVSDCYFLESVDKIRFFYEEAAVDEQSGRLKVPKELALNKVGHALHWLDHNFRKFTFHERIKRIVSLTGAVEPRVVQSMYIFKQPYIGGATHEHVDSTFLHTEHPNNLLGIWIALDSARLDNGCLWFIPGSHKDPRCLSLTKQYKFTSTEAARNERNIAKPSVIGDMLKFLGVRPSFEGYNFVPVECPAGSLVLIHGDVVHKSGQNLSENSRHAYTFHLVDFAGESKGWSSTNWLQGNDTYEFPELFKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H630</accession>
    <name>A0A914H630_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H630"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14015.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14015.t1"/>
        <property type="gene ID" value="Gr19_v10_g14015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_dom"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="70"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="227"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="303"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14015.t1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43504" checksum="B2E1670D61CB23E5" modified="2023-02-22" version="1">MPGKMISLEVDSTESVDNVKKMIQQTEGIPIDQQRLFVQLEDGRRLRDYNIQNGSTLGMVAMEPIAKPKIQLFVKTLTGVIKLEMQASDTVQNVKMKIQEKRGGLCPTKQHLLYKGIQLCEHLTLSDYNMHDEAVLYLIIRPLIPRNESKIILAIEGGKTIELDVKKITDTVHSVKWMIQAVEGIPVNAQQMLFKGTFLKDNVPINDLWFGQPLNLSLKPQFNFDSKYIFVKTSTGKCISLEVQGWNSSYYVMKKIEATEGIRVIEQMLIFEGKQLRDDQSLDDYGIKHESTLELLLFQPNNYEVLMESFGTKKTIKLKLNVWDTVHKIKKLLQEIEAISPGNEYRLYFEGELLKNDDQMLADYNIQKGSKIIYFHAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H697</accession>
    <name>A0A914H697_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H697"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13621.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13621.t2"/>
        <property type="gene ID" value="Gr19_v10_g13621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13621.t2"/>
        </source>
    </evidence>
    <sequence length="469" mass="51462" checksum="88DFE291FC2919A7" modified="2023-02-22" version="1">MASPGDQSLKESLECPVCKDLFSEPKQLECGHTYCLDCVNGLDKVPNVVHRIVGEDFFGVGPVSTLVQSVQNNVQCPQCRKMCLIPDGGLNTNYAIKDMVEKFHQTVQLEDDEYFDGITNAAAREAGTQTKKDEQQQQQLMMCHSCAKRVPGSELFMCKDCNGPPANKQIICALCIVHSHKLHTVVPLVNLASAGDRELAVLRIEEILYQAQRVGDETRSLQTDVTRQFEAVQEKLLAKLDCFRVFQSECRDSEQSALKEDVEAKVGEAIHQCEQLNEHFLRLNELKMEFERQLQRWQDDFGASLPPVPSSAPPLPPPPQQPSLYYLRQYGSIFGPDQQPTATSSTASSGARPMHHFVFSSGGGTGDNDDGPNLVGSSNSSRPRSKKVPPILVAQRRRSRLRGNLGAGAGGGGAGGASGSAAFSSGNNNNSDSNYPPASARTVAANLEQSLRQRQRDDFKRFDENYGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6U8</accession>
    <name>A0A914H6U8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H6U8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13767.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13767.t1"/>
        <property type="gene ID" value="Gr19_v10_g13767"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="68"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="277"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="371"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="594"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13767.t1"/>
        </source>
    </evidence>
    <sequence length="706" mass="80145" checksum="C00805435044B52D" modified="2023-02-22" version="1">MMTKRQTTNDEDNSTNKFISDKKKRLPSLFIGVFLQTVTRQLIAYAISTHVDGNSNYPLEQMQKSAKRPPMNGTEGPSRVLIGIYIESMGNFQSADMSFDVDLYLYSHWRDPSLRHNSDEYVLMTDPKVREQIWLPDLYFANARTSKFHDVTIPNFSLFIDRDGNIAYSTRVTLNVACNLELANYPMDSQTCGIRMVSYAYVASQVNVSWFKIGATRYNPEIGLPEFKIVQLTPESCDGSYMYAIMSDTFKYDKFSCLEAVIHLNRQIGYHVVQSFIPTGLIVMISWVSFWIDRRAVPARVTLSFTTLLSLSTLGNGLRFNLPQVAYAKAIDFWFGSCMFFVFLSLVEFAAVNSYMREAEKYERLASYSAKKETTTTNDDGNGNPWIYSDDDDSSSASRSPILRSQHKNSKNKCDNTSEFNGDNDQNNNNNENEMAIGAKLHNWTNHAIAIPSLFGRCAGDNNKHHGQHHHQTHRRNSHQQQNGPMRLMRHPSILAERILTVEHFEQLAEKRMSNSSQGKAAAAKENHHHCLMQTSPNVETDLRSIDADESDSLMMSPPAPQRKRVISPLTKNSVLPPLRAPSPQAKKPLHLATTISTKTRTNNNNNSEGGCSRAATPTERKHTVPVPTIQPWPPSPMAQQQGAKVPPAAPRRKDQSFRYSRKGLFIDKWSRLLFPLAFALWNTYYWTYYLWFIQRHPSGGTSSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6W8</accession>
    <name>A0A914H6W8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H6W8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1438.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1438.t1"/>
        <property type="gene ID" value="Gr19_v10_g1438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="239"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1438.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39620" checksum="4A9F68A0F8302496" modified="2023-02-22" version="1">MELPQRMLIKDVEVRWNSTFTMLRSLLENRRALAILSQEENLPKFSESEWDLMQAIVQVLEPIYLATKEIESRRCTISSCVPIVSTIIRHLENPLTDANIRLNEFRKAICNGLKLRMAKSGWEQWRCVNSDLPGLSRNKCLGIATMIDPRYKMKFFEAYLTDSHRKILEQAAAEMVTPITESSENAEPQESPVHLGGIFALMEAQQNEDMTFIQPNLDLNRTTSPNLDPRTQSIVQVAEYLAEQPQPFSTDPFLYWKTKEAQGKWPLLCGVARKFMSAPCGSVETRTTFITIERNAHCRLRMDEYETIIILNLLLPDMLYWRLNLYRIASLHIIDKQSQGLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7E0</accession>
    <name>A0A914H7E0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7E0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14398.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14398.t1"/>
        <property type="gene ID" value="Gr19_v10_g14398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14398.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13859" checksum="B65CE5051BBB4DB8" modified="2023-02-22" version="1">MWKIRAGVDVVAEAEQLLLLTNESSINADLPLRFTVCGGKANITLNNTSGREMTWIASFPCGRKRAFSPGTCAWQWASATWAHKFDTVFRREEQPHGERQIMVWFCSSPDVGIGTPWIRMWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7H7</accession>
    <name>A0A914H7H7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sulfotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7H7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13932.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13932.t1"/>
        <property type="gene ID" value="Gr19_v10_g13932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF65">
        <property type="entry name" value="GH20068P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13932.t1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42271" checksum="B398D2B2D841B618" modified="2023-02-22" version="1">MSFCYVSPPTIGPFPDGPIPRQLSPSHRSKRFVPLRRLCLFVCSVVSILQIILLHRRLLPIGASFHSNPKVPEAIGRPAKILLQKISRNETESFVSSVSAAERRLPDCLIIGVRKGGTRALLDALALHARIRVARHEVHFFDRLEVFRLGSEWYRAQMPGATAKEVVVEKTPAYFTNPAVPKRVYALNSSMKMILIVREPVARTISDFTQVHQTKMERHKEPIEFQRKSFVHSPNGSFVLNTQFRPIRNSLYSEHFGRWLEHFSKEQFLVLDGDKFIRDPLSQIRLVEHFLRIGPGVRPDQLLYNHDKGFYCFRHDPTAPVHCLGRSKGRLQMRVTEQFRQILSALLKPYNRRFFSQLNAEFLGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H839</accession>
    <name>A0A914H839_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914H839"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14687.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14687.t1"/>
        <property type="gene ID" value="Gr19_v10_g14687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070611">
        <property type="term" value="F:histone H3R2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000052">
        <property type="entry name" value="Probable histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF10">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="326"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="794"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14687.t1"/>
        </source>
    </evidence>
    <sequence length="906" mass="102037" checksum="087BF8B5D02A08FB" modified="2023-02-22" version="1">MSIPHSLIVRICEFRDSDADDDDDSSAPVVERFFGKFRLIFLASNDALRLDRVAEQHDSAEGSSNGEDVDGFSSFYLALKDYEQMPITEKSIAFCRRCSTQSVPKNGTFSLNSFAIRFNTSKELATFRSILDANANRRDPKTESKQILAKLAETRSKKRKCSDESAANDSNSEFDTRTEQSSAVQYFQFYGSLFQQQNMLQDFTRTATYQRAIFENWHEFRGKVVLDVGAGTGILSFFAAQVGAKRIYAVEASSMAVHCKELVHANGYDAVISVLSAKIEEVELPEQVDVIVSEPMGYMLVNERMLESYMYARKFLRNGGRMFPSRADLHLALFSDDALHQEQQQRAAFWAQQTFHGVTLGVMQQPALDELFRQPVVDSWGAGILVSQSVKWTVDFERDPVERLHRIQVPFTMNAQRTCHVHGVASWFDVAFVGSKRTVWLSTAPTEPLTHWYQVRCLVKQPMLVLAGQDVRGRLEMVANDKQSYDMELEMCIEDNESSAWQRNVLDLKMPHFRYTGQPTAGPPGTQPECPSDQLNQAVNFFGAGGTGDCGMDQEQQQQHQQQMSAFKKQQHFACQADQPLQNGFDPRLSAALGVFVRCVWKVGRPELKAHKMVAENSESVEAVQEVQPEPKATTDDGSSTSFLYFSYGSNMLAERIHVHVTGAVFMTTAVLADFELCFFDRSERWHGAVASIERKPDTRVWGCVWRVPNSLAAELDKQECGYRRLDVDVTIHSIPPSPMRCRTYQYANPDRKLNRPSPHYRQVIITGALEHGLPSAYVEWIVNSFSTNDYRGKVELKLNAIEHLNNLENARNEHREQQQQQQQNEVPGAMFMTTDVLADFELCFFDRSDDSGKEGGLPNGRKLEGAGPQAVLGEQRGGAKQMFGVGGAVELLDIVGTMVVQLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8E6</accession>
    <name>A0A914H8E6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8E6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14195.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14195.t1"/>
        <property type="gene ID" value="Gr19_v10_g14195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037340470" evidence="2">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14195.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="22339" checksum="78E19AA04D047747" modified="2023-02-22" version="1">MATLLPTVVRASLTLAQLLFICSGCAALSNWRGSVFRKQTHDTANTHTFKLPPQSPNVFAASSPPPQSITAAAAAVATDPSQTITAAAAAASATDTHCPPQSPTAVAPTPSTTASLISGEEEMPVDEADNGDQQQQQDEGILQPATTTASISRAHQKGCSCNTAKAKRRQAKNWNKKRRIPGCLDAFLGNEKSESLVTELRNNPKYFEVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8U1</accession>
    <name>A0A914H8U1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8U1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15271.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15271.t1"/>
        <property type="gene ID" value="Gr19_v10_g15271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15271.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39698" checksum="81E777B934074991" modified="2023-02-22" version="1">MFKKFPRRRGSSSTRRRRLADGQLADADSPTVDSPTVRLADADSPTVDSPTVRLADGSTRRRFDSPTVRLADGSTRRRFDSPTPTRRRLTRRRFDSPTVRLADGSTRRRFDSPTVRLADGSSRRRFDLPTVRLADGSTRRRFDLPTVRLADGSTRRRFDSPTVRLADGLTRRRFDSPTVDSPTVDSPTVRLADFDSPTKKREFIARIDEIKMCQPGEQNKLAKDLGISEETFCCWKKEFGLPVNSQIIYSESEKKELMEKYYKIKQRNLKISESDIANILNIPRRTLYGWKKKFVNSIDENSLPDYADNDTSKHSMPSSDDKLWVWNLAKKKRTEKIEVENSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9H9</accession>
    <name>A0A914H9H9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9H9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15042.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15042.t1"/>
        <property type="gene ID" value="Gr19_v10_g15042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037802060" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15042.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7494" checksum="352FEF513B0D2B5A" modified="2023-02-22" version="1">MRTFFLFMGFVVPAILLLMTDASPAVDTTPVLTSENQWDSDACGTGLTLSKGLIAEYTGNNTGKHNSVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9Y2</accession>
    <name>A0A914H9Y2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-lysine N-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914H9Y2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15578.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15578.t2"/>
        <property type="gene ID" value="Gr19_v10_g15578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041523">
        <property type="entry name" value="ROQ_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048575">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052249">
        <property type="entry name" value="Roquin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139">
        <property type="entry name" value="RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139:SF54">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18386">
        <property type="entry name" value="ROQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21206">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="882"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15578.t2"/>
        </source>
    </evidence>
    <sequence length="1040" mass="115838" checksum="90BD8181A8C155BF" modified="2023-02-22" version="1">MEIDNTDDDLSLSQSTLLALNEFLQDQERSRKDGHLFENWQLSQFWYTDETCRQLVDECICALNGSGRVACLSCPSVVAHFMDTKEVKTNAIELSLFEYDTRFADKFGNAFVYYDYRRPLDVPDKFHHQFDVLLVDPPFLSDECLIKVAQTIRLLSKRSESGGSKLLVNTGVVMEQLLKRILDVKKTDFRPSHKNNLANEFYKQHPNQQTRTTTSPMAFGIAQHQLWTEILCCPKCGNVFSVEHLPVTLSCGHLLCSCCVDEHAFCPFDKTAAKWDGSSKMYVNVPVLSIVLGDEELAKQHMERSMKSLCSSDSPQYETVKRLECSLQTFASFLYKVDSEKGATVSSSRLGRAIQHKLFSLLCANLWQEESRAQMLKLLRSMSGQIVSELIPCIEGTVNLSSALWSAVRARGCQFLGPAPQEDVLRHIHRALMRGELLARKTLVLHIVDKLSCQHSSISKTCVGHVVQLLYRASCFNVIKQEGQSSLMQLKEEFRSFETLRFEHDSQIVQIAIDAGLRTHMQTVCDRINSKSLQTDALRKLIDKKQAERNLFGIQTKLEHFDALFTAENLNASENEVWTQIEELLVHMSEVLKVYSDFFENRNAEKEQRRSQKAYVLSRGGRCQDVALLNNGGDHAGVGRTPLRSLARMPPIPIDFGCRPNMVHPPLLYAPQPPQTTTLTTTYIEQPPFPMGSPPGFYTSMSVSSTPFLPPSTNNNNVGSPPLSSPYIQQKQFQMDALETMPGQFFSILPTHPFGPTFVQPLNTVTASANTILTSTTVPSTNNSPLDGRTTLFATAQSTSPFSTSPPGYQFSPASTHMVAPPGAFQIPVQPQSLIVYGSPPFGSPPLLLSPFTNWTTPLDSTGGLLNGANYCNINTVNNNNNTTSLAERSPQKRNEQSFESEEDHQTPNVKRERKYRHSSRTTVDEDDSEWKSDHVSFTVATSVLHGHDEEHSFGSVGWMELPPLPVGQLNMHIPLSPSNVTYTVACDSAKTNLCTIIRPSTSSASTSNTLMTMCPPVSALPIVQDLGTDAAVLKDIPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAA1</accession>
    <name>A0A914HAA1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAA1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15504.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15504.t1"/>
        <property type="gene ID" value="Gr19_v10_g15504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF354">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15504.t1"/>
        </source>
    </evidence>
    <sequence length="380" mass="40343" checksum="626EB58C855DD5F2" modified="2023-02-22" version="1">MVRRNSLEMNSASSPGTCCAQSSFRSLPVVQNRRSRHQHHPLGEESEQYKQEEEERGRENAYKAVLVLSLCLSLCAWTCILTVCPLLYQLISFTTSQFDGILQFCEDTAQTVATESAGLMEMFSREHQYADNDGVDQSQIGGVNRTRSRNFRHVLPLHFQHQLQEQENGCRCAPEPGPQGTPGRMGMKGTPGAKGGPGLPARLPCEPLQDLKKFCPEKCPQGLQGQSGFRGSHGEKGRPGPIGLSGKNGEDGKTGPRGMPGPPGVPGLDGEDGESGTDAQPMPFVPGPPGPGGEIGDSGPPGPRGLPGIDGTQGPQGRKGAQGNAGKMGTSGTPGPTGPIGEPGEDGHKGVCPTYCAMDGGVFFVEPPEWFFKNSQKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAG3</accession>
    <name>A0A914HAG3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HAG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15553.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15553.t1"/>
        <property type="gene ID" value="Gr19_v10_g15553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="5">
        <location>
            <begin position="411"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15553.t1"/>
        </source>
    </evidence>
    <sequence length="466" mass="50385" checksum="59EAADC974FD7B1C" modified="2023-02-22" version="1">MSTENFRIERDTFGELRVPLDRYYGAQTARSMQFFKIGGPEERMPLPVIRAFGYLKKAAATVNQDFGLDPKLTTAICQAADDVISGKLDEHFPLVVWQTGSGTQSNMNVNEVISNRAIEILGGVLGSKSPVHPNDHVNMSQSSNDTFPTAMHVAVAIEITSRLLPSLRFLHEELAKKSKAFEQIIKIGRTHTQDAVPLTLGQEFGAYVTQVANGISRVEATFPRLYELAAGGTAVGTGLNTRKGFAEKVASKLAELTGLPFKTAPNKFEALAAHDALVEVHGALNVVATSLMKIANDVRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEALTMIAAQVFGNQVAVTVGASNGHFELNVFKPLIVRNVLQSVRLLADGAESFTKHCVMGIRANEENIKKLLNDSLMLVTALNPHIGYDNAAKIAKTAHKNGTTLKEEAVKSGLLSAEQFDQWVRPEQMISPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBP5</accession>
    <name>A0A914HBP5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBP5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15596.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15596.t1"/>
        <property type="gene ID" value="Gr19_v10_g15596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF741">
        <property type="entry name" value="PROTEIN PHOSPHATASE FEM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15596.t1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45771" checksum="E0F5FADFFE9B49FF" modified="2023-02-22" version="1">MECKDTLRELIQNCLAAFSSPDASPPIQSRSLIPFTLTSTRDARGDAVSLLVEKMVHSKLPHWSAYILAYDFVDIFAEKLHTGRDSLSDNQIIDASNWCRELRECFAQYLKKIVDGAHKLPPLLDEWEAALPVSFCYQKNRKPKMEDRHLILPSLAVVEPNFVKVSHQNATREDAFFAVFDGHNGAECATYASAHLAECLFDSLEETSDDVEEVLSIAFERLDKRITEKCKSEKIKSGTTVSCVYLKGACAAFLAWCGDSSIGVLRNAGVETLSIPHKPEDQEEMKRIEEAGGMVVSIHGVPRLNGVLNLSRSLGDIQAKPMVSSVPDTKRVELSAGDHVLFLATDGVWDSFEEEEIFELCLEFIRSHPPQDFELLAEFIVNKAKSAGSSDNLTLICIFLRPINEVWTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCH3</accession>
    <name>A0A914HCH3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCH3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16083.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16083.t1"/>
        <property type="gene ID" value="Gr19_v10_g16083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16083.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21984" checksum="0EE5B3CBC49C1509" modified="2023-02-22" version="1">MLRCTARTTWNSSLHSMSAYPRKAQQPFNDAQTPAQPLGCPVGVLPPLVQRPDDCSNRRLTHRATNIGYTPTLMCPQGAVRSLLVNVPAHTQRACVRQQNRFQSTRRPKPTRIIVPEFLEMAQSRAATGGIPRSRTIIAMSEPNHGPVYQPLSGKDKHADFASVARVQPRTSKGITDLLLLNFVRLNTENSTPGGALPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD27</accession>
    <name>A0A914HD27_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="4 10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HD27"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15506.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15506.t1"/>
        <property type="gene ID" value="Gr19_v10_g15506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="542"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15506.t1"/>
        </source>
    </evidence>
    <sequence length="656" mass="74920" checksum="773EB20E1E0AA26F" modified="2023-02-22" version="1">MCHFKKSGGREKDGVESNFTKLRFVSEINTQTGRSNPPPLDLLKPTFCTQRITFPQREIMSIGDVSKWLKSEAHQKFMTFLRCLNSAVKSVSTTSINVTVGETANKIISILDILEAWIDEYPPEDMGKQRFGNKSFKKWFERFVSEGENLLSDLLSEKLKPAVVELWPYLMDSFGNSTRIDYGSGHEAAFVVFLFCLYQLDVLNSPEDDQASVLRIFHRYLKLVRRLQCEYRMEPAGSRGVHAIDDFQFLPFLFGSAQLIDSKQRLIPDYYLRSEMVTQYQSDNLFFEAIQYINQTKVGAFYEHSNQLYNISAVNTWERINEGMFKMYEGEVLKKFPVVQHFLFGTLFAIKEKKTFFINMEDEVKMATEVSNNSFVESKPNDEGPSLGSLGAFLNRFRQMDAKKLHQLASNSAAATQSNGTSETTQKDANAEPSNAASREKMLEVVYGNKLPAKEKPKVMCFVVDAHERRIRIMSRDEQKKQECFALFLDEITDDQLTRFGKSVKDSEADNSDAFVHCDKYRVPSSSSPAETEDRAAATLPAFLYIQNSSIPGAGKGVFTKVDIPVGIVFGPYEGVLTQNVKEMEVSPYAWELRTGNGKTSYYVDAKDARYSNWMRYINSPRNESEQNLIAFQYQGSVYYRVFKPIDRSAELLIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD55</accession>
    <name>A0A914HD55_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="5">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD55"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1553.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1553.t1"/>
        <property type="gene ID" value="Gr19_v10_g1553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1553.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28457" checksum="BEE7F5FDC147AF7F" modified="2023-02-22" version="1">MPGNETIRGRLEKRKDWIRRTRDYQGKATNIRQLKRSARERNPDEFDFHMLRSQVGFDGLHRDLEAEDEEQDEAQRLLDDVNDIEYVRFKLGMERKKIEKLKAVLHFCAGEGSASKPLNKHKIFAEDEDEARSFDPLKFFNTSEQFLGRTFNRPFANEASKTLNEAEKGMLKETEKQRRRLYAELGKRVERERELAVVLQKLELKRDLAQSRKSELRPKLIRKGDAGRAAVYKWKYERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD71</accession>
    <name>A0A914HD71_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leprecan-like alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD71"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1642.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1642.t1"/>
        <property type="gene ID" value="Gr19_v10_g1642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052284">
        <property type="entry name" value="Collagen_mod_leprecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056585">
        <property type="entry name" value="Leprecan_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986:SF8">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986">
        <property type="entry name" value="PROTEIN LYSINE HYDROXYLATION COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23557">
        <property type="entry name" value="TPR_leprecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Leprecan-like alpha-helical" evidence="4">
        <location>
            <begin position="11"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="618"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1642.t1"/>
        </source>
    </evidence>
    <sequence length="761" mass="87326" checksum="EBD3E3A7176DABA2" modified="2023-02-22" version="1">MANSEDPSLTFEQLYQFAKNEYTAENWTDCVAFLLRSLDDFRFFVAETLWCRRKCKDKFPFEYGELVGEDQTPEGRETETIAKGAMFTEAKRALCLLRCRLEKFTDRRPPLRDSELLEEFLHRRQPFHYLQFCYWKLGDLRSAVRAAYTHLVANPSDEDTLNNLHFYMVQPNFHEEMLEDAWQSAHEKLYMKAVRAYDAGQWLNCANLFRQSLDSFWEALEECRALCEDQLDWSSFEGNGTMPPEWPVVVTSFYTSVLRCRQQCPARLQSLNGRRMSHLLVSHFEFLHVCQFKMKHGRDACQSVGNALLLRPRSVVMRRNKLFYRELYGSTTSHQQHEELFRPSKIVRRFVHREASEAAFVQFVDENFRLAKLHSEPSSASLPSTLSRHSSAAPSDLFDYSRFRSPILSLSECRSLRSLGDLFPAAGIFPRWHRLLVEELSRRMVEFYETDEPKFDSIACASKGMTLRSGCERWAIIMQLDADNDKCGQIGTDPFAGAVAKMQESFVTKFRVVQHANCEEVAVECHPQGHIPPPNSWHEQAKGSDEQKNAEDNESVLNNNLDLDYEILLEESKTPAPFYETMGESELNAELSKYGHGPMGKRAAIKLLNRIYEATHPLVSDDTPIPRKVRRALADKDKGKNSRAAEKQREKRTKQKIGQILKGSEMAQQSPEAGNGPHPPGSEEGNGSSDLTKSFLSWLRTPENSKLYDELLALNPVLIDRLFVAFGSELKRLKASRERLAEALDSLGITYCLRTLPGSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD85</accession>
    <name>A0A914HD85_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Autophagy protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD85"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15960.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15960.t1"/>
        <property type="gene ID" value="Gr19_v10_g15960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="347"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15960.t1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52638" checksum="416318D6F272575A" modified="2023-02-22" version="1">MDPTSNDFEARRTIWDSKIPVEFALDSSESVLATQQSCFMMLPRASYFPVYLDKALRILTGGDASEEQLLNAWLQYDGQVLKWHYPIGVLYDIAHGTVFDQTSPWTIIVHLKNFPDELIRCRTKETLKFYFLQSLKEACQLKHRHNIASSMTKDEHARLFDGLYNERFNDFWEVNERLMSFKSPISGDEFGKIPARFYESPHSFRQLLLNSRNHFEDGTSSETLLIDTLQKAFPGYLIETGFEAMVCVPCIILPFVLAIYLKFVQPFILRFVPQRWKLWFDSVLYPTCPVKPTTDAAKMEKNSEDSKGSANPVELAGDVCDGGEQENKKEIPAGMGRPFLEHMGGKKYYTCFRCKTYLTNKREVLSQTFRGATGQAYLFRTVVNIVTAKVESRFMITGQHMVRDVFCKTCNFKLGWMPRYFGAKTARRTRGNGSRTCGAEPTTDAYFLVIFREQQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF46</accession>
    <name>A0A914HF46_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF46"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16941.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16941.t1"/>
        <property type="gene ID" value="Gr19_v10_g16941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16941.t1"/>
        </source>
    </evidence>
    <sequence length="451" mass="52033" checksum="DA6786AB8A82004C" modified="2023-02-22" version="1">MGFWKVTDTDGYPDMEFRKVTDTDGYPDMEFRKVTDTDGYPNMGFWKVTDTDGYPDMEFRKVTDTDGYPDMEFRKVTDTDGYPDMEFRKVTDTDGYPDMEFRKVTDTDGYPNMGFWKVTDTDGYPNMGFWKVTDTDGYPDMGFRKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGFRKVTDTDGYPDMGFRKVTDTDGYPDMGFRKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGFRKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGFRKVTDTDGYPDMGFRKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGFWKVTDTDGYPDMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFP7</accession>
    <name>A0A914HFP7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16940.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16940.t1"/>
        <property type="gene ID" value="Gr19_v10_g16940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16940.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28764" checksum="972DE17B7E4FE4F9" modified="2023-02-22" version="1">MDFIGLVQRLFKFDNSNQNVKRMIIQLNVEVAKCDLFANVTDRAQKMENLCLMDSLLAHLLNNGTMFTAIGQWQKFLTEKQFYNNSAVPRPSDADRHWTKPECHKAEVVDSTQHKLFNTPQLTIWHTGVVLGHLVQKCPRFVQFVNKIVPTLSSISNYGKLSADERILFYKKMLGSTDTEAIKLAEGLLAIKTFFAEMNWMEQANFSAEKFDQIAIGRAELFGTFRMVKVEMPATFWRNEQHLNCFKTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG08</accession>
    <name>A0A914HG08_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG08"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17029.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17029.t1"/>
        <property type="gene ID" value="Gr19_v10_g17029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17029.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="16441" checksum="848B2F1F7743AB43" modified="2023-02-22" version="1">MESDLDKMREQHTKEIVEGRRWLENQRELITAERKAFQEEQSLILDWIEHKKTEMEADKHERREFARQRDADVLRLREEAEQLEQSLAQVESARHALLNARRDLEHKGEQLNELKDALIRSEQRFHWRNRAFAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGC8</accession>
    <name>A0A914HGC8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CYRIA/CYRIB Rac1 binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYRI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGC8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17117.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17117.t1"/>
        <property type="gene ID" value="Gr19_v10_g17117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039789">
        <property type="entry name" value="CYRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12422">
        <property type="entry name" value="GH09096P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="5">
        <location>
            <begin position="183"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17117.t1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45212" checksum="B17690B523123E07" modified="2023-02-22" version="1">MPVEADNRRLFTHSFIPPKHHFHRVNASIVHFPSRRFFREMPEGIIKSCVMASRQPNNGYHYNRQQRCLNGHCLHLPALSIGSKVADATAKFSPKLSIRSKSHHFEYFQPELAELLNELRECILDGNTVVEELERFKQNDGDNLHKEFPVNSSAADETGEDAVRAGKTHREAGALFVRRALFFFLLAIVVRYDTLKSSTPALQNAFSLYRRMSALDSTVGFHLLLAHQSDQISLFLARPTPMLCSLVNGAERFIGRWQKSNRDLAISHMTGALLVIYKVLKHMVERMKPLAGHQSAAHRHRKVPEHFLRSMAGILLLFDHIDSLGVFSPHSPFDIVDFVEMAIQNSGEMEERQLLATLRFFSKNFNSPNTAATMRFSDQSLYNFIRVAISRAGFARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGR4</accession>
    <name>A0A914HGR4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGR4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17212.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17212.t1"/>
        <property type="gene ID" value="Gr19_v10_g17212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17212.t1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48481" checksum="0F0E16BCB5213DA3" modified="2023-02-22" version="1">MRSVKSVRRPNKAISRSRNNQLQRKNNARKRGLDRAKGQRASQIVTLVKAEPNKKRGDTHAKDDTKILNPPRSSGGKEKVVAETPETVQEKKTIKSGIVNNGASDDKNTGKSERKEETEETKSKAKKEVENEKYGDDEKREKEEEKKGKRKKKTEERRKEEGEKVVIKKVEEAESIGTTVSTENSPQRQRMVVELSIDQKATAARKNSEAEAVKTTKVLGNIVEKSANFATWHADEKSGYKAEENDLQWELIGNTRGQRTNEEQQIQVEEARGGEKGWNIFQAEGEAEFVVKKRKTIILSQKEKMVKAEQKKRVERDNGKGSREDGEDNEWEQNGGRAARIGGGQHEQQRRVTKQQENGTRCVDEKKTHIAENNAARAVAPIKVEQLRLERITRVVELKQLLRAYDQGTWERLWGDESRPEERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH46</accession>
    <name>A0A914HH46_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HH46"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17453.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17453.t1"/>
        <property type="gene ID" value="Gr19_v10_g17453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17453.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="59192" checksum="3DF516821969BDC3" modified="2023-02-22" version="1">MGFLGVFVLASLFALISAWLSRKFLRMSRMIDRIQGPTTLPLIGNLHQIRLNPDEFFEQAQGIAYMFNERNCRIARAWLGPIPFVFLFGAEEVEPVLNSNKMLTKMFHYSFLSAWIGEGLLVSKPDKWRPRRKLLTPTFHYDILKDFVPVYNRHGSTLVQKMGKLAEDGQFVDIFHTITLCTLDIICESALGVNIDAQRTIHSDYLDAVFRIKYIIHQRMIKPQFYPEFLFNLFGAGKEQQRCVQILHDFTNKAILARKKAMDDAGGIEKMMAQKAAEGGKGVRMALLDLMLDMRERGELDLAGIQEEVDTFTFEGHDTTSTALNWFLHLMGANPEIQSRVQREIDHVLGPDPAAELRYDDLGELRYLEACLKETLRLYPSVPLIARQVTEDTQIKDFVLPAGTGVVIVPSMVHRDPVYWENPEVFDPERFLKGDYLKHPYCYIPFSAGSRNCIGQRFALMEEKCLITKIFRQFRISSKFRTDEMRVAAELIIRPMLGNWIRLQRREIGEYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH55</accession>
    <name>A0A914HH55_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH55"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17126.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17126.t1"/>
        <property type="gene ID" value="Gr19_v10_g17126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000023">
        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="138"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17126.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27941" checksum="B1CA3A198961F859" modified="2023-02-22" version="1">MLRKSRNTGKGDTPVSPCPPKFPIPDFVKLNGKERKLATKVLELIRLKIPVNKDPPTGKKVETLSSDSSQSGGSAEGQTIVKSATLSAELRSKSRSFDDISIEYGTNELTRSTSGNCMFKTAATSTMPEVTEERVGLVVSKKGYMHFLEGARQEWVRRWVVIRRPYILLYRDDKDLVIRGIINLAIAKIEYNDEQQENAPNTFTVCTTHRAFFMQALPGDDLFDWIGALNPLLAGQIRSRKLTIIPKAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHL5</accession>
    <name>A0A914HHL5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHL5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17238.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17238.t1"/>
        <property type="gene ID" value="Gr19_v10_g17238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17238.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="28406" checksum="0981D3A3CF866E7F" modified="2023-02-22" version="1">MIRSFTLLHRSLLNLRQNAPLTRELSVGLQKKAVMARHLHVTAFRFNPTADDEGKPVENAANFGEVEKSVGTKKASGSMMFGPQTLRLRPGKKENLIRNAVKISQIDGEDAGMAGSKSLLSMNTADIDRQLPTAMTLVQQFDGVPFRELPVVHIKASPNNTIIHVFNIQTKRALLYTSARKEGFKHTKKKSSLAGQTTGTATGQKLLRRGISTVRVVVKGIGPGRISSVKGLAAAGVEVVSISDTTRLPELGPRPKKIRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIA3</accession>
    <name>A0A914HIA3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIA3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17178.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17178.t1"/>
        <property type="gene ID" value="Gr19_v10_g17178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15522">
        <property type="entry name" value="PHD_TAF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="592"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17178.t1"/>
        </source>
    </evidence>
    <sequence length="686" mass="74665" checksum="D5FE520DF68A752C" modified="2023-02-22" version="1">MNVGAARETNENERKSAGYELSRFRHATMAIADNIGFASASSSALSSLSFLLRTYFEQLCRDSLDSAINARRSEVSLEDVSHVFGVNGINLTELHGYIHQVASFAFAEEHPLFPVIEPMSLLSTEIANSEEQKQDERENAGNDGTEVDEEGGREQNNKQVVNSSSSRSNARNAIFQKIFPNFAGAFAPSLGFTVQRVELPVENISVDQQLVNIRPSSSKTAVHTMFEFDHSIAQPLRTKAAISEEEERLLKKKRKKEKREKEKRMAEETEEKTGNDGKRKKHKTKDNSADRGADEESSLLQPPSIPDKQQQPMPISPPQEPLKIPKLKIRIPITQRLSPVGHPPIASIAQENLLISRHTTEPMVPKIIAATLTTITTTPTMTTNVLSKTEAGTIKPSVETIKATKEVTTIPKGLTKILKEVTKTPKEATKTPKVMTKTATETTTTAASKTVDAPNPVTTAIVPMTTSTGATTITTTASIPSAVKQQPTAPFAVTSSGRSVKPSKRKFEESETEKPMDKGPAKPKTASKALKISSTPKLPKTPIFPARANNSAAKVKAIAKAVEQIAAAQLCSASLETVDNAGGANEEEEEPIWICPTCSVAYVEGQEMVACDDCDRWYHWGCVGILIPPPERAQWYCTECRRKRKKSQQQLLTDGGGGSGSNSRKTSLTGAAPLAVTAKKQRVTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIS0</accession>
    <name>A0A914HIS0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17759.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17759.t1"/>
        <property type="gene ID" value="Gr19_v10_g17759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17759.t1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50134" checksum="18E3A933E185529A" modified="2023-02-22" version="1">MDNEAEQFEHEQQQLCGEYEMYTLARFLFLSLSSVLALFGAGANLALFVLFSSRVSLERANTPATLYPRVLALLDASICAGYILLFGADAAVIYLHIRPLFLLYHLYIVPAFVLTRICQLAIPYMLIFATLERLVWISSGKMRNSLLRRMYSVRGRQITVGFTLGACALLRLPTYWATTVHDYPQCDDFFRTKTAGPADWVMSSRFFYVFDFHLLSIAQTVFPFFVLLAFNLVVVRRVSQLSPRHFSPAVLRLPPPAPSKVPTNTAPSSFGSRQFANGRRASFIHRLSLNGPVRSAVYTMVCIVCSYLVSNTLHLALTVLERSNSALLRDPEDPTLASTFHTVFSDIVSFVYMFTSAARSLIYFAFNPSTRAQIRGCFRCNRRPHRRRKHWPQQSPGNLSPPAEDALQTEVPMEVPSSPTEAKQNNWVEFDRRSDPSEEVIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIV4</accession>
    <name>A0A914HIV4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIV4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1857.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1857.t1"/>
        <property type="gene ID" value="Gr19_v10_g1857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1857.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15681" checksum="4AC822329D865203" modified="2023-02-22" version="1">MNQRTSVRPSVSIPFTAGGTVGSNSFLEMDQKDAAFREANHTQQRQNYREDRRPDFYCYQTSQKMRNCGESMSSAQFFGRRFDGEYRRPVDMKEKQQRTINLDGLLGINMEQFMEFLEAVSIATSGHPYFPNRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK25</accession>
    <name>A0A914HK25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17341.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17341.t1"/>
        <property type="gene ID" value="Gr19_v10_g17341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051438">
        <property type="entry name" value="RNF_E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17341.t1"/>
        </source>
    </evidence>
    <sequence length="464" mass="52205" checksum="81F85CAAC4B21E34" modified="2023-02-22" version="1">MSSERYKEQAAQIFYFLSVLADFPRRMFRSLPTASSPAKFASASAQSEAADELCCFLCKNMFNEPLILSCGHSFCRHCIQPWLRRATVCPFCRCPTLPPIPNTTITQKVAEFKRIDSSGKSNFIRNALRRTIHSSKEARMLQREAMRASQRRPKNVVLPERAEDANLEADATKEMGQQQQQFSRMGNLRKSFLRIKNKYAQQMDDDANANANKCRVSVHSFRSATTGSAIGPLQTEIRRAFSVHLDNARHIELTEGKESPAELTVEIGIAQRIVLVCRIDQRESFECIQKMFEYYSPKAINTMKGKKKFVLLGLIISQKTREVDRMSGEKLADLLGTRFCEIELAVLEKTFPIWFHSPRPNLASIESSLRPPGASVGGPSRRLPATALPPRPLIQLVSPQRSISDDFRPAMGLSGSAIRRSELANPKTALLLERPEEQQKKRKKKNAEEMEKGGQRVGGGCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL23</accession>
    <name>A0A914HL23_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Battenin</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HL23"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2122.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2122.t2"/>
        <property type="gene ID" value="Gr19_v10_g2122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF8">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2122.t2"/>
        </source>
    </evidence>
    <sequence length="722" mass="81240" checksum="A9CA30D57AB81665" modified="2023-02-22" version="1">MEKKSLIRDLIAFWIFGLANNFAYVIMLSAAEDIIKGQTASSYHENSTKNTSVAQICRPVLPKPRCEITSTGAILLADIIPALIIKLFCPFLMDRVPFGFRHFVVCAMQALSSGLGENCLLALSSHYKRNLKFSIFDPQLRHGLPALGVPELNALLSMLIVPILFAFAYWLLLTPSPSVHRMQIRSPSTWIVPVPSEKVDLNEVVAEQVQRSSTTELSFGAKMRLTVPLLRLMLPMCVVYFAEYLINSGLYQLLHFDCVHGFGLNEASQFRWYQTLYQLGVFISRSSVTWLELPTLILYLLAVLQCGNVLIFYCQALFHYIPHIGVVFTIILVEGLFGGASYVNTFTKIHKKAPKEIREFSLSIVASSDSLGVTLAGFVSILLHNHICILQQNESKLMAPYMEFLFDLDHFRYSGFLIVINNKMRITGESCRMFGNLFSFELNGQWTGIACSHYMVRYEPAPLHLRMVSPVFFNLFVRQLLTIMLTVVRFSCPPAHEYLRQCPNHPLCIPAKLFCDSMDNCGMGSDELWCPVPPLQQNPSTVSSTTFDELDQLNSSSKLAQSMYIFFDTVQSLSALWAFVLVVLVVSFLMTLTGITVRKRNRRRRYQDRPTIRNLFGSVMPFSGGSQATAGSAGQLQRSSNDDETMGLLTLGLKNVLQSLPDQHWHNAGYEGIMETEGGQLQGHQNENGATTAEQYLLTINQQEVNSAGQRRVHWLTNEVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMG4</accession>
    <name>A0A914HMG4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMG4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2142.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2142.t2"/>
        <property type="gene ID" value="Gr19_v10_g2142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2142.t2"/>
        </source>
    </evidence>
    <sequence length="286" mass="32717" checksum="8B1E7D375C4DE14D" modified="2023-02-22" version="1">MTDILAQRDSTGIYYEPYERDFKLCIHEEPDVQGRNERYEFRCDSQLSCCGRVCCVPAAAAGAGTILGLPWWLFLLLPLLLLLLLLAALAYLLYRLCRKKRGEKEVVKRSTRTSRHATRPYQSEAGYRSIDRAGDDRGGGLLRQSDVEAEPNGHAKLVDDQRIESGFDRPYRRSFHEEETFEEEFHEEIEMDLPSLPLPKKEELKPLVYPKSPPASLPPTRRVVMPSPLEEYDVPTPQPIRAVERELPGSHQSLTTMCRQSESPQRAQHAFYSTHTDQVASYNPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMK9</accession>
    <name>A0A914HMK9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g1977.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1977.t2"/>
        <property type="gene ID" value="Gr19_v10_g1977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="980"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1424"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1425"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1440"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1466"/>
            <end position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1977.t2"/>
        </source>
    </evidence>
    <sequence length="1848" mass="201936" checksum="9FF15781284EB568" modified="2023-02-22" version="1">MEETPPPPVEGLRRSKRNNKYHLDVASLLLSSSSTIRRDVSPPSPVKKSAGRKQPAQQQVHQVQHVQQQTAVLVVEQQQQSVPGLQTQQQKRRSKPKTSTLASSTATTLAASAGTTLASSAAAVVKLRTTVNSALTAAMVAGMTASSTATTAMTTETTTTSSATTIALKTVTTTAVSSSSTAMAGMTTSSAGNAMPTVTSSLPATASSSIEMVGPQAVPTPAEHETLGLQTVVNSDNLKEDKAEACVTTTTKMPKNVQQRKDEDKLEAFSPPALTTATSLMTTTTSILETNPQQILDIQLPDQILEEDSSEDAPLAPPSEQQQQATPSAGQPAQVVAAPSADAPPVKWTTTVVSENGTGGSSSSNRGTLPPNMAPPATNDSVQQQQQTKRKRKVPLKHQDYFNGKQADEDDDDLEEQMLFKAVKVEYTMPDGSKSVDEHACPKCPAVFDSRVGLTNHLKLHGSKKEFPCELCDFACTNKKTMRQHRRVHGLSRRSRNTATTTNVVVKSEFSAVPKSSGAFVPSAEHVQPASSSWPKRCCLNLDRLAAQSRGSIEVTTTTFKPISNCSTVADVAKLVTQMHERKLLKAEEELNRRKQQQQQQQQQQQKQGGGGMDEEDDEEDAMPVLEQQQQLRLNSMVDEQRNINQQQQQQQLGAYGDADERCVEEEEAAGEESSGNGRKASTSSAGGGGGKAYDRNTVQCPHCPFRTQSKQRLQPHVSGHTRASGFRCSACGFKSESSGFLRRHSQLHDEPCKWPPDYVGVPHQRIAKLLEGRSHKAELVVTIADDNNGGTTSSSNMDGSDKFNQYMERNSNQQQQMEQEVVEGVESVHKLIKMEMNEFNEDEHDEIVVEEMEVDECKTPAADEAAAVNKFRWSSQLIADRWNAYQKRCLQIRPPHGPSFINSNATLRPPSLRWLFCGRCQLRCHSGPAQFALHNTRHHRFMGQNRLALCRELLAERLAWRDDRGDGIEYEFTAALSSSNGRGEERRTTSPPSSADVSLDGTATSTTITGAAGGKVYRCRSCPFSTDQIFRLQKHENKHLVKSDHQCSHCSFSCRSLDILAQHKRLHEDGGGGFMTMTMMTEQCSTISSINCQPPASAALLTATASSSSSTTAQPPVDDVAADAASVEQPTTALCAQQQQQMVALSATRLAPIRRNEAHYCPHCPYSSKHNCDMKAHMKMHEVRSKFACSLCTYSTKRQNALIAHEQLHRKGPLLGSPAVLGPRGAKCRRLKRIVLLKQCRRRNSSSIIVPFGERIRFDGARTHFYRCAHRDCGEEVPFCADLARHARNHCMPSTAGAPSAMPSMTTVAASSLLLFRCEQCSFSTMLEHRLKAHQAATHNRGIGGEEFSEKNARTDAGIFKCKECPFATVNYAKFWNHRQKHKRTNRFTCKHCSFSSGSVQCYAEHMALHGHLQQQQLQLNAGVDDDNNLPSGEEEEAMMSTTTTTTTLTGTMMMMGPLAKKSTKNRDKEYDEEEGNTKMEESSSSSSPEGTKTAITEASAVADTEVQLLPQAFSSTMAQAQQQQRRSPIFQWDKFEQFDAALPPTKHMKTMNGMDVELSSSDSSSAATTTSSASSKICCCSECPFETVHAVLLKLHMEMHRHGACRPFACALCSFGCFSAESLHAHLSMHASATALEGGGNGTRTADSTPTESGGGGLLCAGGPFSALNNATTATAAAASVVVSSSVYACSQCSFKSTELEQFLNHRKEHVQLLQQRLMTIIKRAAVDNLNSASVGNGGTKMDKISKALGGRTIDKQHYCTRCSFRCDSVQAFTRHWEHHRIDGCRPGMFKCSVCDYSSNTHNVVLFHEHNHHLDIPLTSLCRNIELVQQQPEQMPVGKNIGLNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNR5</accession>
    <name>A0A914HNR5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNR5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2296.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2296.t1"/>
        <property type="gene ID" value="Gr19_v10_g2296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2296.t1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48761" checksum="6FDEE501D1D43513" modified="2023-02-22" version="1">MALRFNCLRRFQHRLRYFECRGGTAGLRRTLATAQFSRAATPALPNVCSARRTCARLPVRAHAAPALCTLLQNFGRPGGHQPTRSIKNGFLLSVKMAVRRYCAVTARGVSMTVASVGQMPLFSVPKKDACDEHYLRAKELRQEQELFPMAGTLPQFGANGGAGGGGMAFLSSSGSSKVQLMFRKRFKEMEKRRKAEEEALHRKSYAETDVKRLERELEERMIRIHSLWVLSHGRYDEWASMGNRLMSNDFVGQLNADNCQFLIVKALFSQLLKRGLAPNIGNVRRTMTINGINNLCSFSIGCKSHLAAKIANFETGTCGNWKSPFEKVPNASECTGGYLGWHWRTETRILINVVRSRLVKMKKAAKFPQKARIHAHLTEPECDKWLESGGVFCPKPNLQTFFPANRHISIVLGHPKIVFFNCAYHQTTDKWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ60</accession>
    <name>A0A914HQ60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3421.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3421.t1"/>
        <property type="gene ID" value="Gr19_v10_g3421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3421.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="24447" checksum="6BC611C17E5C794B" modified="2023-02-22" version="1">MAPKGTGANGTKGARQLAKKGTGAIGTQKAPSQGKRPQLKQKAPAQLDTKRPMAQKAPANGTQKAPAPIGTQGTGANWQKRPAPIGTQKAPSPIGTKRHRRQLATKGAAPRQKKDRRQLAHKRHRRQLAKGSGANSKQKGAMQKKKAPMHKSPAPIGHKRPSPIGTKRPIENTKGRRQLAQKGPAPIGTKGTAPIGTQKAQAPIAHKAPGPIAHKRPGPGTKGAGAMNKRPGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ63</accession>
    <name>A0A914HQ63_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ63"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3215.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3215.t1"/>
        <property type="gene ID" value="Gr19_v10_g3215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3215.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21991" checksum="005D7AE6F949DEDD" modified="2023-02-22" version="1">MVNNNNNISDSMSRTGRKRSQADVERAEATEQKKAEKARRRERKNGKKPNEAAQSHDCARKTAMRSIHYESTRALPPPLDPRLQRQLQPTPSTLRPPVTRAPPYCARQRQYLRHCAHRHCFWRLAASAATACSADPQPPPPPPTTTTTTTTAVERRKQPGQRKQQQRQTTAKKRRLASSTTHGRKTTLNQCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQI4</accession>
    <name>A0A914HQI4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HQI4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2777.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2777.t1"/>
        <property type="gene ID" value="Gr19_v10_g2777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2777.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27937" checksum="2A6F51C3DEC7F75C" modified="2023-02-22" version="1">MIFSPRRPIQNVLTVVRNNLERLWTQLAILKKFPPPTGRNVPQHARAAKLKWQHEQKLITDIRCVPTSIQTRHWLLAANLSVYSPDELDQLDLAIDGADEVDEDLNCIKGGGGCLLQEKIVQSCAKRFVIIGGLDKYSQRLGQSFEFIPIEISPIGYVPIQRWITEKFGGECSLRMFKCSPVLTENHNFMIDWKFPKAFASEANWKAVNRQILCLPGVAETGLFIGVAEKAFFATPEGQVRCVFPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQL1</accession>
    <name>A0A914HQL1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQL1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3738.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3738.t1"/>
        <property type="gene ID" value="Gr19_v10_g3738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF73">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036711594" evidence="2">
        <location>
            <begin position="25"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="68"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3738.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35227" checksum="BF8921F4FB09CEE3" modified="2023-02-22" version="1">MNVFFVILVLILATVLLDYGYCSAVHRMPLHKKQKAPNAFASRESMQCAHHNKQPYNLIVFDINDIEYYVQISIGTPPQAFSVLLDTGSSVLPDAGCFLGCKHYGDEFCTAQCDEQCCGQNAKFERVTMPKSCQNVTKFNSHASSTYRKRNITFSLLYDTGFAVGSICQDVVKIPDRVKAFTLGDIDDENCGGITDWIPIIPNELGQWNVNIDNITLDDGTSISALNTGIVGSGTSLLYGPSDVKVGPITFLINGHDYQLTKDTLILNCKQQGDTECTFGILGDATRPYWLLETRFVRNSAKFTTLNIKHLHCLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR70</accession>
    <name>A0A914HR70_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor-related protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR70"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3888.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3888.t1"/>
        <property type="gene ID" value="Gr19_v10_g3888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
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        <property type="term" value="F:GTP binding"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
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    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3888.t1"/>
        </source>
    </evidence>
    <sequence length="369" mass="39637" checksum="B27464F819846429" modified="2023-02-22" version="1">MFSLFRGAYGEITRKDEFFVALLGLDGAGKTTYLERLKAHFDRHYCGRNLAKIGPTVGLNHVRIPLKDIVLNVWDLGGQAELRSLWGSYLAECHALVFVVDSADVQRLPEVFSALETIFAIERICQLPLMILFNKCDLDQPKNEEAAVALDGCSRDSAETLTTTTYADGNCTVPGARYFNINGSAAGGDSSTPTPNPNSLISSNTGTTTAASATGGSATACPPVIPSSSSPPPPLVSPATLCSSSGSGWQSFELDNCDERVVVVVAAGASYSNGAAGGDSTTTDDCWEQLSSSTSSSTTLDQQRRHINNNSDQNGLMERFRRQYFNNHISSRHQADVAIFSVSALQNVNVKRSVTWLTNALSSTIQRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS65</accession>
    <name>A0A914HS65_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HS65"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4165.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4165.t1"/>
        <property type="gene ID" value="Gr19_v10_g4165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4165.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12539" checksum="7A24C11FD261CB46" modified="2023-02-22" version="1">MCAEIRTTPSGLETTSLVFAYGIDLFYTRVTPSGTFDILKDDFDLLFLLDLSTLLFNGSKFEYDSDCARTHSLTHALAQSPAVFTNWTETLNSNNNNLVLTMETLFFCCATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSB4</accession>
    <name>A0A914HSB4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 23</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g420.t2">
        <property type="protein sequence ID" value="Gr19_v10_g420.t2"/>
        <property type="gene ID" value="Gr19_v10_g420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1489"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1725"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1551"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1563"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1742"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g420.t2"/>
        </source>
    </evidence>
    <sequence length="1904" mass="215870" checksum="39C448E9C448C96B" modified="2023-02-22" version="1">MNDSNVSTSYSAAATVLPPSTAIEECSAQSPSFNFLCVGNEAEKLKWLVLNHVKPNTLKKMFAPLMTTKRCALNRADELVCVQACMLFRSLEPPESDRNRQPVELEQACYSLIGLLTYNSNIITLLLTCQLLVASIDFRMKIPLNPEKIKFVRKSMDQLDYKNMRDLLKLLLVEKLDKMQCQLTEHQQRHLAPIESLVIDLIDRSKNYCPALFFITEISRIDPCHSSIHFLPRVSWKIREMVASFRPLAEIGSMLGRSWMWPVPTSPCFSWSSQTWSAWKLDEKQCKLYFKTHLPYSSENTTPQTYLQYILFKQPHGQDNLNHILRSANSMTPTPRIQCDEVIQLLILEAMCAMEDSEQPVLASVNQYNWLHLSHLVTHALFMQNCTLSELLKMLLPQLRSCQYLRAKEELMWILLQLVAHARHFQRLIHRQEHKLGNDLFHRESTKYAAIWINLVHSAPNHASSASAENQPPEKLKTLIGFIEQQLDSSKLPDDKALALLAVIANSYSNSREVFEEHVSTAVFRILGFNAQHPQGPSHQPEKFWCLPGGRRTEHNLRALDLTFLDSLTFHAKMQIYKSTFRVFGHLFSHSVLPNFASLRLPTPALAESTARLLLSTELIDLNGSIFYTYIFTALKSANIIPNSAPEQQLYFVRNDLLAMFLELLNFRLQNIGFGWKWTLDQRLQFFFMVLDSLNRGPLSVSPCPSSNSLQLCFLLEQFIQRFVQCTWPQDLLNATQCLMKMMPGWMMAMPEYCRLFQLAVFRAAKLLGADQLQFSSQDLGQRWSLSELRWFPPNILHAIVPSESDLTQLEQMQATQQAQAMMELHNMANQEMQRLMQLDAEYFGLDSPPNHPPAPSLLVSIFRCLHEYATAHPQLPHGKQPHPNAPNFLALCYKLLSLQSNRDLHRSTNALVDYLVWKHQGSTQQGPSGMLADDPLSHQQLDLRMVAVLNDMLFVHQFISVERFLLSLALHPSDDSSIRTSLFLLATLLDKFSSFSDRLHACHAFAPAHSNTTGSNSEEFFVQIADFFKKYPEYSYAELYRKTMMDPAFQQSQEQPRDPHNLPIYYGHLADRIIPLIDVILQRALEVDVGPKVLDTFLRHFAHLYRLHPQPMTFLYKTLYTLDAFHRDSAVGRQIIRKFVLSIVLKLEQDEGNHGTRGGAGYQCKLLTAEFMLRDHEMPAIRFCRVLVERIVQASTYTHQPPQFVHKDWRFAEYPPAGQALTSAWVEILATNHAPATIVDALVELAIRRPIFRPQDTLNALGLLLTGLPSAFQTLLLDRVEESFEWPQIASPDADPSQLFESLSHEVYLHSDSRILSMLALIHSFCQHGGNNSLSIIPDLVVKRLAHKVENEAQLVYFLRIVVPYLQRIHEKERNKHMPEIVAIYTVLGNLVQKVGRLKYEDTICDLLYQFKYMFVGYSLKEQTEMAIRNFPDSMREKLKFLFTHSSTAAAAAESQQQVQQILQQQQQQLQHQSSQWSMSSVPTGGVPLTSACHPSLLPSGSFPPLPSLQQQQPTALVGMLQRQNQGEERERQQQHQSGGPSVSIGGGAAQQQQQQINSNQHPQQLGSMMGGSATNQQQPIPTPMSVSSVSSAAVSPNLMNPQQQIVPPPPPYQMHSMMMSGTHAGAMPLHNIAFPPSSSGAGIPPSVASTAQQQPSMVMHSHALPSHHHLHQQQIVSSTQFQQQHLMMQQQQMSNPFGSSPNATAEGLSPGIFLPMGFQPHQQMQSHQMTSEHHQPPDATMSQQSFPSHYSQSGPSGCVPSYHRPGMRIEFAPFPQSPSMPPSPLSVGISLLPIAFLINCSFLLSPLALLPVSATPFDRFPISPSGIYRLGTDTLGDYQKKLQLLDGRVNALEDSKTPKKTRRLKLAEMLMKNGFRDEAQLKYLRHVVKWELEERQKARSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSN4</accession>
    <name>A0A914HSN4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSN4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3597.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3597.t1"/>
        <property type="gene ID" value="Gr19_v10_g3597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037985671" evidence="5">
        <location>
            <begin position="23"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="557"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3597.t1"/>
        </source>
    </evidence>
    <sequence length="684" mass="76150" checksum="ECB3CDED9A1794B7" modified="2023-02-22" version="1">MILSITLLKLIATLIIYGSAGGHNRHVVDAQETATLSPCGRTPNYTICSTRAPNLQQACLMGLQSKAASDKAVCDCRIVTWDQLPPVSAAITLPTFRQPTKKEQDAQPPPSQIRSDLYSSLDIKSICEAVRGIYLGDQQCYYDPNNTASTTLASSIGVRERRQAGTPNATLFKCTRKEYRMLSTDERTRYHNALLQLKQGHGSYEYNRIAALHSDPAQMPGGHGGPTFVCWHREYLKRLEIALRAVDPSVCLPFWDSTLDWRLPSPSDSILWSDLLMGSPDENGYVTNGFLTNWLTADGDPIRRYLGDGALFPLNAADNILSSDQMYNIFAFADYGVENCNIQDYNNVLEDNHNNVHVFVSGDMAYLETAPQDPIFFMHHCFIDYIWEQWRLRWQNRTERETQFPPYSQIDSCTYGNTYYQLNETMVPFLDPALQNSVCLSNNYTDFLYTYSLSPTCEKAGGCGSPFLFCDTTNQTYPFHPTCCSKIKPDGDCSIFVRNSEQPCFNSTCNESTGKCQQFQQLNMLKKVELDANRNCHGNSSDTTPSPTPAPSKSRVCYDHHECCAQWVANGTCDAAKQSMSVWCPGSCHYDGCQPHPKAGGTPAAGGCMDVLDQCERWAKVVQHPGHGHGLGRAVPPIPMTECARNVHFMARNCAKSCNKCGVTTNALQCASLTPKDYKSSINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSS1</accession>
    <name>A0A914HSS1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSS1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3877.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3877.t1"/>
        <property type="gene ID" value="Gr19_v10_g3877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3877.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16064" checksum="3D9B256239DA9E26" modified="2023-02-22" version="1">MDKVNIEGAETFIDCTVIPSVELEYDGVTNGAEKDEYSVKELKARMAVLMGGMGTDIAQIEDNAAMIADATSRRGRRLTRAQRRETIAELKEEAEAAARAVLRKETIKKLNGDSSTEMAALKRAALKRAALKRRRTEMAALKRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSX9</accession>
    <name>A0A914HSX9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSX9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3674.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3674.t1"/>
        <property type="gene ID" value="Gr19_v10_g3674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3674.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="13881" checksum="0274F83412BFC257" modified="2023-02-22" version="1">MTSSMIPSLGQGQLYGNCPPGNYADGSCATLHVCIDPHERCINGICCQPMDNMPFGYGSGFPLPAWHHGPIGSMIGGGPHGSCFDLEESCINFVQHCNVPSVTEVCTHTCGLCHNQPPYVPLPYGGGGGIMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV04</accession>
    <name>A0A914HV04_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HV04"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4239.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4239.t1"/>
        <property type="gene ID" value="Gr19_v10_g4239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4239.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39710" checksum="7F40D67448D3B3F6" modified="2023-02-22" version="1">MSILFLHLIQSFLPRRENPQKTPWKIAISSDVLLDTCCFIERAELGLKMATICARFDRIADARLGSRKYKFACGWLDFVQRTGDGAATIVKRWPERWTERAWPIPDEPMPNTLSYFEHIRVTCFDRSVLNCLHRILSHLGPSTNIQIGFYNRSLQTTDFEQRVVELAQLHLMSQCGTIYIPHELNLTTFRLGISQWLHTPRADGRPKMLKCNVWHMSGALEYIWAIILQFVNASDAVNFIVQLNLPTPFGTGRALSTMVNKRTRERLAIRHSVNNDGNCWGVRLLRFSAEADGETVRRWTEWERHEEDKEWEWIYRSIDTRTEYPKHNVFVSKNVINFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVP4</accession>
    <name>A0A914HVP4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVP4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g442.t1">
        <property type="protein sequence ID" value="Gr19_v10_g442.t1"/>
        <property type="gene ID" value="Gr19_v10_g442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000027">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="31"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="239"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g442.t1"/>
        </source>
    </evidence>
    <sequence length="485" mass="55095" checksum="B10BC1CAB793644F" modified="2023-02-22" version="1">MLIVAILPSSIAPQMPMPPASAASAPSDSLLLDYLFSGYDKRIRPFADSPVPVFIELTIVLAILTELRENQQVASYVISHIQKWRDPRLSWDPAMFNGLRQIVVPRADVWLPKLFIYNSMDTKEMLSDNYFDVRLTHQGKLKINMPQYVTCICRLDIALFPFDTQFCAIAQASPLLGVEEMDVNVTEPPKDSYFSGNAEWELFNVSVRDTKFWEDGEQRVEVHYVMHMRRRPVYYLTVIVAPTFLISFLSILGIFAPGTNEGPRSEKVSLGLGSLLAMSVLLDIVSAAMPKSNEIPLLGFYIISTILLCALAVAVNMALLTVSRRFVKMGQIPSKNVYSSLLLDPSTSPRGDKYWEERYEQYLSTSEAADEQSKGHQQQQQQTKGGAARRASANFCPSMGPFVDARVLLAFNCQLKEIVAAQRVFRKKIEKRKRHVTVEKEWNRVFSQFDYFFLFVFSAANLCLLFMFLRYSWQPIPQISPNFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWA4</accession>
    <name>A0A914HWA4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWA4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4743.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4743.t1"/>
        <property type="gene ID" value="Gr19_v10_g4743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4743.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="55761" checksum="3B58E59BAB7EFC3E" modified="2023-02-22" version="1">MFQHDLGLINHLVVQQQQQQQQQQRQIKKEMSEDQQQQRMNNQTKCAGGGASHQQHRHPQRIPSASSSISSGVASEPDMARTSPTALINNLLGRNSSSTHQLQQQQQQLNEQLGGRGNNVIGHQIGPNSAGLNGALLQGIDFAANQLANYAGHFHDQLDMNSLFGTNNIAGVAAGPFSVYSTPGPISSMHVASIASTAENSVPLSAAGIASHRRQRSTAGNSLKCLYCPKKVIGGQAELQAHLEDCRLLRMHECNQCGKRFKARGGLQQHSKIHINDRPYHCHYCPKRFTQKSHLDQHERIHTGLKPFTCQYCGRQFRQRSQQLGHEATHVNRERHSMGGLSSMSAAVLGGLVGAAGGYGETMCGRERGAPNVAQKQQQEMAAAVGAQLSPEQQQQQQQQAGQSSPTRPLLCPGRSAESINGHGTRHFQRQQQLANTDLCCGGGVNASAMAHTHQQQMNSFNGLLRAVQSNDSAAVDGLLGLRGSIPMKQQHGHSGMELNEQLQLVSAHLMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWK7</accession>
    <name>A0A914HWK7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWK7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4695.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4695.t1"/>
        <property type="gene ID" value="Gr19_v10_g4695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4695.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33616" checksum="9C4453AD5999BB5D" modified="2023-02-22" version="1">MPFLLRRPDTMPSLDEWWEPPPQFQQQMPKQRLWRERRHSEDNGQSETAEAGVNAKWRVDLCVYKRHGFAAVPSLVAYARARVKHAHLCVGDRVRVLLVDINFIELYNAEGGSEPRGRAATRTTAFGQQKLLWHTSSSRAVVGQLHIGGRGIFRMVMFLTAQCVEELQSIRDWLRFLVVRQRIPHLVMGLQFSWATKQKRSRHAAFLVGTFECRLLSAGALDVSEMPEELICELSRNDVIIDAVLMPPPQSDKTSAQINENAMAVEQVKQQKNKWAVIKITKFQKLFKKVKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWT3</accession>
    <name>A0A914HWT3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Intermediate filament protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWT3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5202.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5202.t2"/>
        <property type="gene ID" value="Gr19_v10_g5202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1260:FF:000003">
        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000058">
        <property type="entry name" value="Intermediate filament protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016451">
        <property type="entry name" value="Intermed_filament_ifa/ifb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF12">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005546">
        <property type="entry name" value="Intermed_filamnt_Ifb-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="182"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="7">
        <location>
            <begin position="568"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="172"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="440"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51841"/>
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            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5202.t2"/>
        </source>
    </evidence>
    <sequence length="688" mass="79054" checksum="D6E7B26C82F0B089" modified="2023-02-22" version="1">MKQSEKQRQRLRHVRAEQLNSASDVSSEGSISPEVRRVQKVEETSTTQTVPSRKRVPPPPPPKPPHSIFGTGTAHQQTTVASEPHLRESSFSSVYSNFPQTYSTLHTYNTMDSPASSDYRSAISSRPYFPRPRPLSPARYSSDGGPRVLKMVSECSSISSRPMSPYPGSTAASAIRDAREREKKEMSELNDRLANYIEKVRFLEAQNRKLATDLDFLHKRWGKDASNVREMYETDLRQAKKLLEEAQRQKNELEKKAKAMGDEMETLMKKHADALSAHDEDKKLMEELLLNLSSLEAELGTLKRRLGILEDDLKALRRENQHLSGETHKARTDLDQETLNRIDYQNQVQTLLEEIDFLRRAHEAEIQDLQAMASRDTTGENREFFRNELASAIREIRSNYDALDTRNRSDIESWYKMKVQEIQTMSARQNLEQNYAKEEVKRLRTQLGDLRGKLADLEGRNSLLERQVEELAYQLEDDQRAYESALNDKDSQIRKLRDEAQALMLELQMLLDTKQTLDAEIAIYRKMLEGEEDRSGLYQLVEQVVKSQNIRRQDEAESQRVLRGEKSSRQSYQRSAKGNVSVLETSPEGKYVVLENTHRSKEEPIGGWKLRRRIDGKREIMYTFPQEFVLRPGKTVKVWARGQGLNAPPDQLVSDGEESFGTGSNVQTLLYNRDGEERASLIQRCSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX47</accession>
    <name>A0A914HX47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g547.t2">
        <property type="protein sequence ID" value="Gr19_v10_g547.t2"/>
        <property type="gene ID" value="Gr19_v10_g547"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g547.t2"/>
        </source>
    </evidence>
    <sequence length="171" mass="19076" checksum="98E70E596CCBA032" modified="2023-02-22" version="1">MNDRGQISYRLISQSVQIFDLNFSESSFRVSTDLSLIALRSDLTEIVLNLGNDCILPNQPNFKGEGRVTINDIDANYLRNQTAELSVDGNKTNQSVSTLMSGWNDLVKSSHGCLVVDVPKECLCQIRDQLVVLLHIDIIVCRPKQGIKFVLVKDDFDQNDDELPSGMAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY05</accession>
    <name>A0A914HY05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5699.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5699.t2"/>
        <property type="gene ID" value="Gr19_v10_g5699"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5699.t2"/>
        </source>
    </evidence>
    <sequence length="295" mass="33371" checksum="749AF04F9BB5E32D" modified="2023-02-22" version="1">MNNNSTPNSSNADFFLVGRCSDRSFLLNSTGTDSNSYAFTSVPNFSAIRGTFRNKTIFFNGHFTYEINDFFHEAIDNVHTLYIIRELKKFMDVLGGNAEDLSTFFGCALRIVVETPIELGELGREEETKNVTNCADNETTAKADDEKKNDGKDDSESDGNESESDESIMNDAPFFKFIRAIVNNFLELSTSRSRHGRLPDDESCVKRWEDNFFDELFNTYTGEVLRILRIPVTEDDGHADDADAKFVLHDVFVLRCARGEMDTLPSDLNALFASDQFDCRVICVEKPPEKVAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY61</accession>
    <name>A0A914HY61_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small ribosomal subunit protein mS39</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS39 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HY61"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5194.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5194.t1"/>
        <property type="gene ID" value="Gr19_v10_g5194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055063">
        <property type="entry name" value="Rib_mS39_PPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22330">
        <property type="entry name" value="Rib_mS39_PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="repeat" description="PPR" evidence="12">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5194.t1"/>
        </source>
    </evidence>
    <sequence length="585" mass="67890" checksum="71B3F1B3292B396A" modified="2023-02-22" version="1">MGASKLMNMRFRRLFLPFRYNHNFVSVKHIPFAIPEPIQRSPTDLLEALANTVKDDETSSHFGLIDDPITIPTSSTSKKIYLMSRELGRRTARKLVEEWPTLFMFDRDTPELSAFRPQKPLDPSLVEPNEENLRKMIMDRRVPDAIKLYQNIAGNDENKADVSKTLKLHLFRLACYYNEEDFPLTEFEEWHAIRYFYLRQNDSTEWKEGGIAERLFAELPKTEELFSTLICALCKFRGEYSLRRARELYKEMTSIGLIPFEEAFNSLLFARVSLDDSGVFNVSHWLQEMSRLGVRPSVQTFNSALNSLLLPDSVRLGEVDKQQLVSDGTAKLDGMPGESKAAKASDKQRWKAALDLVYEMRRQKIEPTLETFTHTLSLAYSRTVLAGLLDEVLSLLEDKLARSEDIKRTGENDAVFYRDAMFIAHALNNEAQIDRLMKVYKSDHNQVFFECDDVEQSFFTEFFYSKLEVLPLEAFYVLYKSYIPRLLGVHSSLIKGVLRTIKERKPAEFCFPLLKRVVEDSISSSLIAFDSFACRILVQLSDVKPRLLNLPDWESYMELCKKVIDVIERLDLQKIEKENYRKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZD8</accession>
    <name>A0A914HZD8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZD8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5487.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5487.t1"/>
        <property type="gene ID" value="Gr19_v10_g5487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF194">
        <property type="entry name" value="CUTICLE COLLAGEN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5487.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="30693" checksum="780B0A9928FEB903" modified="2023-02-22" version="1">MPHISRAMQETKALIGLAFLCSAGAIISVLIVIPRLSQQMNALNLRVLDTVQAFRVDTDSAWTDLMGAQNLLIPPNAEGSNPFNSIFLRHKRQEGLPLQCVCHLEQPQCVPGTPGPTGPPGPAGQPGESGLPGVDGQPGSQQLCAGASNECLTCPAGAPGQPGEQGQPGPPGSDGMPGQPAQNLGQEGPPGPMGPSGPAGVPGQPGAPGCPGQPGTPGSSSVPLPGLAGPPGSPGEAGIPGEPGEPGQPGGQGPPGPSGVPGEPGSQGEPGQFGNVGTPGQPGHDGAYCPCPLRTTVYFALRAKKAKKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZJ8</accession>
    <name>A0A914HZJ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZJ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6117.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6117.t1"/>
        <property type="gene ID" value="Gr19_v10_g6117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6117.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36918" checksum="A91050B1A813F986" modified="2023-02-22" version="1">MDRTTYKDAVVATGALGIGVGLAATQFGLLIGSAAANLMLDCLISTKNAGKDALNRGLSIEQAIEKRIYTAIEATQEIAKNPSEQLTAHANTFLDIANSLSESILGIPRAVEDPESGLKDRVTFLASRIATRISSQTNERIIEPLQQQMCVLTEQLSKCIVLQRQEWTFNKTEAMRTRKNPGEVLLQIIRFYSSKLNNQMGKLRDRSSEVLLSSSLQTQIQSLTMYVQKLDDNFAKAESIDDVKQEVIEEAKHKLFDIARWSASLSLRGPSKDTATEDDDNDDKPKQYLQKANDDDEPKQHLQKADDDDNDDEPKNPLQEEEEGESSEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0C9</accession>
    <name>A0A914I0C9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anillin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0C9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g57.t1">
        <property type="protein sequence ID" value="Gr19_v10_g57.t1"/>
        <property type="gene ID" value="Gr19_v10_g57"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF24">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anillin homology" evidence="2">
        <location>
            <begin position="39"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g57.t1"/>
        </source>
    </evidence>
    <sequence length="766" mass="85306" checksum="AEB64B102F4B12F1" modified="2023-02-22" version="1">MLKFQRSSKNATDSPTLSSRSLPPDRRCSFVSSQLGQSRAVVVIRKISVPLAWPVEEYFSARKDWREFILQLVLRTADGKEFVSKPMEKINRTYTDVNFPDEFIFTDQAHNFTIELTVYCRRTDKSGTNSSKVHTFSRSLGRSLGQSWKRYVQQQHEQQQQREIASSNGPNKSFLEMLRRAGEEEDKRRSLGLPPLMLDEEHMADHGQPSQMCAVGNAHFRLQNASLSGRVHNYAMDKLPATAAVERQELLPIYGSVCAQILLQPSSLVSPLAHGSLDIFLPDQGILHQRLRCSLQGGQLKCWDLEAGNSENASRSSNWSLISLSPGKVPILTLPINEATRVEKTAFPTAFRLIFNAQEQTNLTTTNILCICATRSALLGWRSALQLQILDCSVWSDFALRLRNPHGAGLGPLVGAAGPPTFQRLVGMETTDNEEDDGTEDSLKIRNITPIDDKMPISKNEERPRASSSASMLFRKELPMSSIKHGPNGFESKNGAASHQKALSRTTLLDTSGQLTMTTGTFGESRASAPASPSLSIIRRKTMQTAADDVTDNRSPSILRRFSQRPRQNISWSLRELCPAEQQNGATDFFMNNSLDLTPLSPETSMSPPTIEEEEPEDEIETIDKNKHKKMDENEHQQSNYVISLQIKPHETNDNCPIDSSFKSAPTGTMPTMEMNANEKTTLLTSPISSSTPTGNNHLIHCIKVNASASSPNDNTSAPSKEMHKNNRPFHVNNGLSQSPARWTRAHIGRSETWHFARIGEACTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0K8</accession>
    <name>A0A914I0K8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0K8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6377.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6377.t1"/>
        <property type="gene ID" value="Gr19_v10_g6377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6377.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16826" checksum="29C236E0DD1D806D" modified="2023-02-22" version="1">MCPPKHSINVVIEHGLPEDRERIVRSLQGNILKYAQDKFASNVIKKCLVFGTLEQKNALIDEVCADNGSGSPPLLEMIKDPFGNKVVQKMLNVADSARRRKMIVALLEYLANGLSKKSFIAYRTAFKQKQRAAPNNERIHNGIPPLLMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3R7</accession>
    <name>A0A914I3R7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3R7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6330.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6330.t2"/>
        <property type="gene ID" value="Gr19_v10_g6330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037410506" evidence="1">
        <location>
            <begin position="26"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6330.t2"/>
        </source>
    </evidence>
    <sequence length="686" mass="78678" checksum="D33EE1A4A2F731FC" modified="2023-02-22" version="1">MFKFFYYSFFFVIKFFSLPARATCCAPPPSPISVLQYPNIQGAGVSQYANIYFMNGVPPSQQQNTILWQRQGAPSVKMVENDNTVAQITAQNATENITTLPNDDELLKSGSTMELAPRINAFKPNLLIRPIENIKKINANLTAFRCPLNESARKLSIDDLLSSIEVAARPFDGLSNVNGILPVPLPIQFCTFEEPKFDDKQQCSFYSSESENLQFKIGRFCNKTMPTALFVKSFANQIKRPIDDLPKDNFLMLIEPFGVVPSNSAILKMDIACQKGDGQLSFNYWCTTEQFVLKVCTRFNFVRQCTPQIFNSHNSSRVEVLVVNPSLESFGQFSVEIIAEDFAEPSLMILDNLHYEAKQCPIYDEQENVAQKNKEFVNGNTSKNYSKISIKQNGLEQYIKELSPKNSNKFNKIYANMRPVVDGAVTRHKKPFFDAISEDENAIEVNIAKRELLKIGGKLAMFGQQRTNLAENSADLLPQIQFRRRNNRQPKLHRKLPNACELLKCTFTDTFCHWSQLEQMPFMKIRTGKWQIAKPQELSFLMETREKISNLQHSGYAYIGNDQTLHGIVPKKEVMLDNHHHRTRRTVYVLQSPEFVLSKNCSNSALIFDLYKRTNAIIMKICLNSMMNCVYEAPYSEVNVYWRMREKIELPPDTNKIYVIATQWKRISWLAIDNIRLLEDGTECQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4R1</accession>
    <name>A0A914I4R1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4R1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6596.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6596.t1"/>
        <property type="gene ID" value="Gr19_v10_g6596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6596.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9936" checksum="0E5BD9AD094F9573" modified="2023-02-22" version="1">MEPSKSQSLSNIGGDQTKDNKHKRSGQIVFRMPNFKEFSEGRGPLEVFSAPVVYINGLPCAMAIKLTWRGLVVPLSNSALFLARKAMKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5H4</accession>
    <name>A0A914I5H4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5H4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6961.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6961.t1"/>
        <property type="gene ID" value="Gr19_v10_g6961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070828">
        <property type="term" value="P:heterochromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051516">
        <property type="entry name" value="SETDB_methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pre-SET" evidence="9">
        <location>
            <begin position="49"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="120"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6961.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37428" checksum="A251D9D6E043DA54" modified="2023-02-22" version="1">MVHSVSGADISNGRASIPIPWVNDVDDVELPNFDYQFLPKFTESLPKRMFCACRDGCSAEKGCSCVGMSTIKLSKSGHVHDAHLLSENAFDSQFFECSADCACAGTCANRLAPANDTQRHQLQIFKTPKAGFACKTMKAIRKGSFVCFLGGEVLPTDYPTIKPKDYEQIEAPDKVCFTFIDNMRQAAFFIRFDKVANESRFFNSSCCPNLRTVHLFRDWLSPDRPLVAFIAICEISAGDELSHYYGDRWILDRLCAKPKSICCCGAPFCVWPPHANRREDLFSRPKDRQLKAKTVRAELKQRDQRREAERRGTKKRRMDPEAAAVDQLEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5L0</accession>
    <name>A0A914I5L0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STRIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5L0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7723.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7723.t2"/>
        <property type="gene ID" value="Gr19_v10_g7723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="4">
        <location>
            <begin position="680"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7723.t2"/>
        </source>
    </evidence>
    <sequence length="1093" mass="123558" checksum="BCB43B85489E3F7F" modified="2023-02-22" version="1">MSAEPTSLKSVESRPVRPEFAEAVYGTTNHPQQQQTSIAKSCNQTSEMCSALLRVESTRWSELAELYTYSEMDEFALNFECFGRYLRERKKEPIWDDLPAKEKSNILQNIVESFENSDSEHRLEAARIILYILQGAYGDFTDIEAKDSDRWSTEAICANSATEEDSDGKGLNAAPKWFGKDNGTGGFEQDCLVRSALNAYQVYEHGLFQPLCSLLRLEDNLPFERHADHSRQSSVSNSRSASHMDLANSSDGPGGGGTSGSASGTLEHRRSRRSATLADNERIRVSINCIYHIVEAIRREDLLEKIEEYSRSSGMFCLPEIQHHPNVSSKYSMDRLRSLRQQFLTELEEPMENKETLLVHLLEMMPSFILLLCWKVLLATLGGIDFLRDQKAMKRTQAGLSPVADTVHVANKMKPLLNCDGTVAAGGILGLNTAIAGGGEKAEQDAGTITGQLGRKLRSIHHQVRPFNRQVACSSSSDQAIPMTHNGPYHHERNNVFSRDTEGGGGETKLARRLLGRRRKMRNLNLWRRRKVVHCSTKCWKNFPRQQTRKRGGNEKQSQIKITLSTGETRAQSLSVDHGKRRPEELQLLLIDQPHESLTATNKNRGNDVVINADGGDQTPKACESPAKLNSLWPPPPPTGLPWRPKVRESDIENFLQTQRKKHFNFQLPPGDSITVFALPEPIVKGSLAALRRNLYVPLSELQLKTEDRYNRYPFSQKEFVEDCPAERLYVRILPGMTEYVIALLKVILASLPSSKAKIDAVTILSDVLTPETDTNEVLSNSISLDLANFSHTNVLEETVRVAIDINRHKELIIKAASAILILLLKHLRLNHVFQFENFARYLVLANCLPLSKHELIPFNYPQCALFFVRNGNEWPQLTADNVDGCGGASESPSYFLWRNGKQARTQMLVVYKSAPVLKRCMRAKLGIFQLYVLKLLKMQARYLGRQWRKSNMDLISGIYLRVRHRLNDDWAYANEVMRTKSIDSQQEENELGMAIRRFNARRYPHIYRDGAESHGGGGREGDEQQQAGVSSAAVELAKVSLLDDWDPKEWEPMDNSLQSALAWEPQFSERFTQNYEQWLEEEGIVGHLLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6P2</accession>
    <name>A0A914I6P2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6P2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7254.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7254.t2"/>
        <property type="gene ID" value="Gr19_v10_g7254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7254.t2"/>
        </source>
    </evidence>
    <sequence length="143" mass="16024" checksum="A4551B71F0665E72" modified="2023-02-22" version="1">MVEFWEEQRQRERLMMRQTDCPPQQEGVEEFMDIYFAAGAALCLRTVVATAAAGTMPNGTKAILPTLARLDIDGVTASEALSLILVRSVAMHRKRKWAKSAVPNTATMQMNDDVRRALSVISEQKHFVITQIDQLSVVLQSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I731</accession>
    <name>A0A914I731_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I731"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7226.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7226.t1"/>
        <property type="gene ID" value="Gr19_v10_g7226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="12"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7226.t1"/>
        </source>
    </evidence>
    <sequence length="662" mass="73181" checksum="424A19E4A4B8EB7C" modified="2023-02-22" version="1">MPNSIISVSGGNWVVLDVAGKEFRTSRGSMQREPGSLLALMVDGTMDPDELCNESNGRIYSSDEGWSIDMDPRVFEALLKYLRTGKLVGRLPEGVTDEDLKSEAEFLRLPKLMELCDMSSSSPRDNSSISMMGSRYASTMSLYQHQHFPTINEPPPGIPIRPSHPPDFGHSVTATTAAAVGAHIAAPPGFRAPPGFDIGLSDSRTTNKFDNSSNKSADIFSSRIDNTGSLSNISSDLASNKFDIDGYKPDIISGKSESGSKFDISSNKFDISEALKEAFNSDPTDNSTATVVQQQSLSALSPRSQNVQEAQNARLPMSSSFSSNENLHSISQREPSPPPVAHTVAPASPPAPSASFARAQYYQLSGPAVLNFQQAHQQMENRANEILTMVDGQASPDRSLYQRFANLGAVLHALQRLHRLHPDGFTVEQYVQFENRQKRGRPTQEGFFFNNIMPTVVSLLESDDDLLRVDRKNGTFHVSAEVAQTRLFCLGKNLCSNLYRLLRRYSDNAIRVQQLFDIAPKLVPKGAPAPDTNALLALCNCHPTIFKLCCSPQDNYRFDTAWIMLNDLLLNNIIFCYQNAEFDYQSQRRRLVKYLRTGKLVGRLPEGVTDEDLKSEAEFLRLPKLMELCDMSSSSPRDNSTAHTAGHPRLGLSVAFPDTLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I790</accession>
    <name>A0A914I790_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I790"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8152.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8152.t1"/>
        <property type="gene ID" value="Gr19_v10_g8152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF1">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8152.t1"/>
        </source>
    </evidence>
    <sequence length="536" mass="60662" checksum="045F192BA1DE6317" modified="2023-02-22" version="1">MTVYESKLRKANIVPVKRSNNSSLCSSPDSSQYCCSCLEIIGGRLYNCSRCNSSFHSICHFPALPIKINKGNCSDWICHRCEIEVQYNRRHLPRIKCNSDSQEKEDALNQSLVRFMLRLSGKDGAPSEDFSEFVNSLKTINSREFTLEKLDIDESYYKLPFDELFESYEPNSKNCFYCKRFVEKKMVSCDFCDTSFCLDCPNPPFTALPNERWMCSFHIEPFIDVYLLSSKRITDRMALWKEHTKLQKTDSFHSVISNFYKKIEAENIKRGSELEANSPKRRKKPTQCTFKVEKQQTNEETPSSPIDVGSPDDARLSIAVEALIKMHNQSDDVKEGDSYQDPAFDTKCVSDDGVLASALESNTNVEQPRLCFFNPGLLNRKLPIFAALKILSGADKNVTDSEFLIPVQSPFVTLGPLKVNSLHNIDLSGFTHCKMLGTQQALIFFDKAKLAFEMVAANLFVDESFPFRKCAKSARRSADLVSECACQKAEVGDEPTFWLLDPTRGIVPSQKSAVLWNGAIIRIGCLRLHFIGLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I985</accession>
    <name>A0A914I985_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I985"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8448.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8448.t2"/>
        <property type="gene ID" value="Gr19_v10_g8448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8448.t2"/>
        </source>
    </evidence>
    <sequence length="698" mass="77421" checksum="F560C03E4AFA590B" modified="2023-02-22" version="1">MTLVTVSVSLSPYVQRYKQSLAQDEHKAVKDERTLEEIEELRKTKAAAVKRDFEEGKVSTAEGAQSAKEEVHGLDRSTLGQFKDKFENLSDTLQQNMAEKMQAGATKDELEEIKSQVNEVKQKWRTGDLEGAENLEDSATRDELEALKGVNVKGRFQPGQGEFHKSYDRSELDTSGAADARKSFLEGSAFAGREVSSAAAGEMSELKFTALDAYKDKFEKGPYAEDIQRARVELDLQLDELKQAFEKPESEMSPEERLAKKRAEIEAEFARYKLTRKLRAKQQQEEGGDETAAAGAQETFFPSYCTTVNCTTVHLYGGVLPEPLPPNHRMRAQPPPVYVKDAVTLTVHVYSSVYNTVYPHVLPLTEAPTTILCCVVVVFVLDVCPHTLCQNTFRAAPLMPFQCQCLPSSPTTASTSVCAGCPPIDRSISRRFRLLTIAPPPLFPLSMVDDGGGGAVVEANVLPMAYEEEGAHRNVAVRLDDVVYQHQHDDAETDAGDVAAADAAAAFVADIATYGNTSWSSGWTDQVVQQLLHTGADTARRTRSAATASRRHRRRLCSGDDAGEEEGEYDVKNLMNKFLNIDLTPKERASKLDELEALRVEAKNLTKKFEQPNLDSVEVSEDKRRQLEAEFQQLKEERQQARKEYEEEMAESAALGGEKEEIQVAADHASKMAAKWEKIHAKEAKKAEKSKMPAKSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9U5</accession>
    <name>A0A914I9U5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9U5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7942.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7942.t1"/>
        <property type="gene ID" value="Gr19_v10_g7942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037345384" evidence="5">
        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="99"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7942.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="32916" checksum="FD919F40749355D6" modified="2023-02-22" version="1">MPTTILWLPLLTLFADNANANSHICFTQMPTTILWHPLPTLFVDNANAIICFTHILSQRLKPASKMRFFHFLDAVCLFVVAAFILLETDAAPKTSTSNTKLKNEPAKQKNPGLTPENEWNSKSNACHPHLTLSVPKRLLVVKHNEKKSMWSSVFAVKPIPKTSSGTFYYEVTILGKECMVAIGLCTKPMPLDKEIGELKGTYAYQSCGMFSTGPDEQNKLLKSNGKDIPSISDGDTVGCGVDFKNKNIFYTLNGERLGTGGEFVDSAVKLFPCVSLSKEGDEIEANFGPIFQYKAANGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAV9</accession>
    <name>A0A914IAV9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">lysoplasmalogenase</fullName>
            <ecNumber evidence="6">3.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:22544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:73359"/>
            <dbReference type="ChEBI" id="CHEBI:77287"/>
            <dbReference type="EC" id="3.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:16905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:73359"/>
            <dbReference type="ChEBI" id="CHEBI:77288"/>
            <dbReference type="ChEBI" id="CHEBI:143890"/>
            <dbReference type="EC" id="3.3.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.2" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914IAV9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8203.t4">
        <property type="protein sequence ID" value="Gr19_v10_g8203.t4"/>
        <property type="gene ID" value="Gr19_v10_g8203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047408">
        <property type="term" value="F:alkenylglycerophosphocholine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="TMEM86B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885:SF6">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037182805" description="lysoplasmalogenase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8203.t4"/>
        </source>
    </evidence>
    <sequence length="409" mass="46463" checksum="5B3D1F8D997CB8A5" modified="2023-02-22" version="1">MHKLVIYVLLIAFFYEQTGGFNEQLGFQYSFLKALPILCLALFVNFGWYSVKRTHRQRYLLVASLLAAAGGDFVISIRENIEPSFALSALFFAAAHILYMAFLLPFLRHPFVPLTLCCAAYVVVMNYAFLLPHVVTHPFSTLVLMTYSVVLTTAFIISGSLMFVGTHFQPPLQKSNVMHFVGFCFFYLSDTLLLLEHADVKFPPCYKEELILSTYYMSQYLIDLRESKCQLYLILTSGDKHSPFGTGSEGCWNCWTIGLALQKRRRISRLHFEHRPIFSGTSTAFNNENIVDYVPIANVRHLPPLSLCVLVAVLTSLCTQLAVFLLSCLWAALRKCFDRRRRNGTVVGSAASINRHQSDKLLCCTTTLTPTRKRRRGEGPKTTEGEADRAKTADCCGDKTWRRIIQVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB73</accession>
    <name>A0A914IB73_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rubicon Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB73"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8596.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8596.t2"/>
        <property type="gene ID" value="Gr19_v10_g8596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052428">
        <property type="entry name" value="Autophagy_HostDef_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971">
        <property type="entry name" value="PHOX (PX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971:SF1">
        <property type="entry name" value="RUBICON, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="2">
        <location>
            <begin position="325"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8596.t2"/>
        </source>
    </evidence>
    <sequence length="550" mass="63375" checksum="0D3A67FD8D104724" modified="2023-02-22" version="1">MCSEESSRSCSSRRANNLNLLTVTPAFPIPISPDILFSKLKESTHFTRGRCSSSVFVAEELSPENQSKLFAQDNLWDRLSLVSNDSVSSVSETEKDRQPIDQDKICVQLSDWLIHSMEERKWRQLTEGLDFRNEIDPVLHLGTVSPGTSDIQQSRLCSSPAMDYHREEGNSVFYTLSNEDTSQMATTSRVYDVAVDKSEPLSPPPLRLSPTLTRRRRSSDSHAMRKVPDYWDGPFVKRTSSIQQLIAVLAENLPPSPNALRRAEVLRTFDIPTFRIPSRKWRPPKKLFIFEHSKPMDFITQLALQKHRCAGCGLKLDHVYVKRTLYCHYYLKLFCQCCHQGSKARIPALILHDWNFKEYPPVFNVRLISPGLYRRAKNLRKFRKLRVKVAHMWPFVQMCKLAAELMTENGLTMFSSVPKRFLALESVDVFSLLDFERIANRNLIELVEPLALKGAAHIESCERCRQNAFLCQLCMDPNDLLFPFQVERCHRCDGCGSLTHWKCYRKTTTTNVLAETGVEEVRCEKCERIRRKKFRLQRKASPDRSTCGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBC6</accession>
    <name>A0A914IBC6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBC6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9017.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9017.t1"/>
        <property type="gene ID" value="Gr19_v10_g9017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9017.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23319" checksum="D0850E7859F81469" modified="2023-02-22" version="1">MHFSVPVTETDDETPAEDNITVGSEERGRREGRERHTAVLRTDRHFSPFAGDRILLPILKDHQSATITLETILQLHKSILGRHIGAGVLRTHDVSVGDDFDAMDWDEVPAEMEKFVSWLNAEMNAGVMSAGELAARASHRFNAATQPAAAEPLFTSILKTKKAQSTAGSPQHQIIFGKQLCNQNIHQKLEFSAKKLDSVVKLRKKRQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBD2</accession>
    <name>A0A914IBD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9275.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9275.t1"/>
        <property type="gene ID" value="Gr19_v10_g9275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9275.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="42443" checksum="8C3D56010BC59CB7" modified="2023-02-22" version="1">MLQFTLIVIFINPINIIGNTNGALQPETQKNFRAYLNRPATNSSSAFEHRIDVPEENASLLEKISNNQLLSNPSKPTHTFDHRIDIPDNLSFIQQHEFSVDRTDVRCQQHRGSPFPDLLFSKNGDPRLFPVSPFPENQYSTSNCSVYEHIIDIPETATFLEQFESSPYEIKSNYKFAQFPQNEYQTSINVGQNLIGIVNKFSNYCRHIDGNVQRRVVEPNMDMGKKLCFVGMFVSMSEFINKKMTENIEQFTKRHKNWVSANPKLRQRLGLYDVNKHAVPKQFLERQNTSQMADLYTNMIFYSLSIDQMFNFWIKTKSIMTAANKTNDDKDQKHRILSQEIKKKLDDLTRETLFDFISSKIELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBE1</accession>
    <name>A0A914IBE1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBE1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9029.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9029.t1"/>
        <property type="gene ID" value="Gr19_v10_g9029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037732761" evidence="2">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9029.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15929" checksum="2889D196C48D8971" modified="2023-02-22" version="1">MMPAKLFPMPTLFLFLGLLWLDLVSSTKMIETEGNTSNSAANSANNGPAQALPSTPEKLMAQCLICPPAPKKLRLTSADTSPPPATRGRIISLEEIDRFFAFADPKIATRKLFNTPPMSLIHSQTNKQEMDEPVKEVTDDVKETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICF1</accession>
    <name>A0A914ICF1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICF1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9546.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9546.t1"/>
        <property type="gene ID" value="Gr19_v10_g9546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF245">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="76"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="304"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9546.t1"/>
        </source>
    </evidence>
    <sequence length="389" mass="45672" checksum="2F4E88962BD394C0" modified="2023-02-22" version="1">MTSDIGTKCNYELQTGAITARWGKRRAFHEKKLMGLCESQETKAMIARSKEIDKQLHLDFMAQKKVVKLLLLGSAEAGKTTMVKQMKIMHANGFCEDERLEFKEYVYSNIIDGMFMLLNAMKQMNIAFDNPNLEIYADKVLEMKERHEERRPFDLKMVEALRALWTDKNLTEKVLSRRNEFYFVENSIYFLDSLDRVSAIDYVPTVQDILNLRIETTEIVQVSYEIRGVNFCVFDVGGCRSERRKWIHCFDHVQSIIFISAISEFDQKSRETPSVNRLIESMRIFSTICNSRWFIRTGFILFLNKRDLFEQKIRQGKSISACFKNYFGEETYEVQLEFVSKKFVQLNKNPRKHIWVHFTCVTDTNQISLIWNNTTVVIIQKVLQGYGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICF5</accession>
    <name>A0A914ICF5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9550.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9550.t1"/>
        <property type="gene ID" value="Gr19_v10_g9550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9550.t1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51276" checksum="0E0E68D99D8D5CA2" modified="2023-02-22" version="1">MFMTSLWPFMKILDKTVAESFYGLVLALYSISQIITSPLLGYWSNRIERLKPPLIFCNLMMLLGNILYLFVELFPTHHYRYALCTSRFMAGVGWAQLGLLKSYVAAASLVADRSRATAFITGGFALGVILGPALQTLFTLVNYPGFPVCFVNRYCINISMFTVPAIFASLVNVALMILLMVRFRESHVGIIERVNMVNETLQIKKSTKLPPYDRCAVAVCFALRFTQFFVFTIIETIGTSFAMLMFNWSPIEVVFYDSMAHAVRGVVALLVYVAYIIFDLGKIVNDRIVCLLSLVALLFFYLITHTWPFLPEHVRLMNSSFVGNSSANSGGCNLNKYAWCAGLPRVNPWLYYGAIVLLIGPAFPNINVAMNTLFSRIIGPRIQSTQQGLLEMHGAIGRLIGPLLISFFYLSYGRYFVDNHRRLLGSAMSNMGTDEEVQIINFLISSVYLSSSVALFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICI2</accession>
    <name>A0A914ICI2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosolic Fe-S cluster assembly factor NUBP1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICI2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8662.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8662.t1"/>
        <property type="gene ID" value="Gr19_v10_g8662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8662.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="33482" checksum="786FA394D80A0832" modified="2023-02-22" version="1">MSDVPEDANAGCPGTASTGAGKSSACAGCPNQRACSTGEKVVDPDIELIRDRLAGVKHKLLVLSGKGGVGKSTVAASLAYAIANLDGAAKPLKVAVLDVDICGPSQARMFGCEEDSVHTGDQGWAPIIVQENLFVMSIAFLLDSRDEAIIWRGPRKNALIKQFLRDVDWGELDFLIIDTPPGTSDEHISIVQLLLQASCLDGAVIVTTPQEISLLDVRKEVNFCVKTKVPVLGVVENMCQFVCPCCSTASQLFPTTTGGAKKMCADLGLELLAQLPLDPRLAKSLDEGQSLAKSVADKCRTNQQRAEMNGENEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID37</accession>
    <name>A0A914ID37_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ID37"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8778.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8778.t1"/>
        <property type="gene ID" value="Gr19_v10_g8778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901:SF2">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037195970" evidence="4">
        <location>
            <begin position="32"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="194"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="6">
        <location>
            <begin position="306"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8778.t1"/>
        </source>
    </evidence>
    <sequence length="679" mass="73595" checksum="B189BA98E4070017" modified="2023-02-22" version="1">MRRSFSRRRDPPVELLQLIPLLALLPAIVHAHFSLTFPETRYPPFDFLDTQRTVGPCGIPKSDRSFVTKFQTGKPYKISWRMAMEHKGTFRLRLLDSAGKALDNWVLRPNGTALTQFTDGTSANSVEVQFPSDCRNCTLLMEKEAPELGEQLAEKGCAEVDISAEPEKPCLGKGKSVGGHCQCEQGFSGDQCQYRDDCTDDGDCGHGGRCVAGAIHHGQRSCFCPFGFIGTNCERKSGSDPKDSRCFSHGGPLNGSSHSNSSQEFVYGLFNPNCYSSKELNSDGDRLYWRLVGNQLELLLDFRANSWVSLGWRPLNIPPSCRLFPQIHAASEGGGRHGQDGLQTSGFAKAALDSPLHPMDCSDVIMASVLEGTDLLHIADMYSRDRSSPLRDAWLDGEDSLSAAYGLASDGRMVVMFRRMVPEIEPTDHPLGPGKLFLIWAKGQSKKHKDKGFYSDGQWKYHGDGGGRGHLQLEFVSLAQMGKIRGPLIHLDPPPPPAPPHVPPATDTIEQRTDKVPEEGKKKVPPTTAVTPSGTKMENPQTKKASPEAPTTKSVFLTTATTQSPTTAKKESKAQNSTTTTAERTSTRQPSAAAPSATEGKSTNAANIGTTHGKATDRPEVRPEHAEDAATAAEDAEEGEEDNALPPSSRSTTAHAMLPTVLLGSVSAVVVVALFHLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDH9</accession>
    <name>A0A914IDH9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDH9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9603.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9603.t1"/>
        <property type="gene ID" value="Gr19_v10_g9603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9603.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39574" checksum="F59675D9E128DFDD" modified="2023-02-22" version="1">MSDNPKKVEKQMEEIPICSDLLFEVFEFCGPFVLGLKVALISDTFDRLVDAHFESKEWELGDLQISRSKDGNSAEIVKCVDGKVERRLPIPHEPFSDNVSGFKSLEIRYIDRCVIEFLELISPHFASKGVNLSIGTAENQDRSWKIIWKKIWPLIKGNICGISLYSFELYHLRRFSPIMICDCPKLRMVNSGYNFPEFTAGDSAGASTAQALAKWLHTPRGDKLPKVLRCYFWSKGMEALKLEFVNSTNPVNFIISLWVRPSADIVPFKLRNNLTGQQFVLQCFDVVEWLLIRCPIERDEEKWAKWEKEAAKWDWRRQWNRINVSFNDREIGDGMLVANEGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEA0</accession>
    <name>A0A914IEA0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEA0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9099.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9099.t1"/>
        <property type="gene ID" value="Gr19_v10_g9099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9099.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="32881" checksum="AD752F7B550DCBEC" modified="2023-02-22" version="1">MMKNRRPENAYQNKEHCKIAREIARELGTSRDNIYQWKRDLGKTQKPNKQYVDDYDDKTKLARHRVKIEGKIANKLGIYRAKIIQWKSEIKQRQSMEEDNQTKLSLIKKFDKIKNEYKQKDIYNYKQRANIECGIAKELGTNRDQIYKWKRQLVSERKSFTSEQKREIIEQFDKLKEQFSCKFKSKPTKQIEEKFAQKFDISAQSIHNWKKDFGLIRAKKHKYTDSERLEIIAKYDNMKKNNPALSDEQIVKSFDIKMSTIKQWRRKLGIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IES0</accession>
    <name>A0A914IES0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IES0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9936.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9936.t2"/>
        <property type="gene ID" value="Gr19_v10_g9936"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g9937.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9937.t2"/>
        <property type="gene ID" value="Gr19_v10_g9937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9936.t2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9937.t2"/>
        </source>
    </evidence>
    <sequence length="376" mass="43035" checksum="E6E46A39D36F2A9D" modified="2023-02-22" version="1">MNEFTSIPFSDLPERVLRFAMKLFQLLTSLFLVVSLYNIGPHWVLLLASLAVPLFGLYVLFGSQERILRHHPLPYVRYKSQSRARSWLRIDVTISATMAVICVAFAVVLFIGYFQEHSANGSLLQAAISALLLFLLYSLNALLCVRQLKMGQVDFLAEKEKHNSVVSTTRSSSKSPLNALLSPQSVPEAWQHSLEKAFPQIITPTKMRRIKDWEGKRDVRRKTSRRIRVEKRGNTEFGMDMGMWRTLEEQRIGGDGKIRRKRQLDSGEVLAGVENDRHGRINEKKKMTKLSRFDMPRRADAPQEAGHPGSAEDEKRGTESKGIGMALKREDPMERKFDVPIRSKWNPVMISTDSVSISAEERKRTEKMRHEQVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFH9</accession>
    <name>A0A914IFH9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Latrophilin Cirl</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g9429.t4">
        <property type="protein sequence ID" value="Gr19_v10_g9429.t4"/>
        <property type="gene ID" value="Gr19_v10_g9429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF465">
        <property type="entry name" value="GPS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036742115" evidence="14">
        <location>
            <begin position="26"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="889"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="16">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="15">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="17">
        <location>
            <begin position="653"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1286"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1044"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1286"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9429.t4"/>
        </source>
    </evidence>
    <sequence length="1332" mass="147183" checksum="2CD8703D95835601" modified="2023-02-22" version="1">MLTSRHTTFAGILFILSTIFQQTICADESLITVLVCEGGLASLHCPPQHEIVVHLANFGRFSLQTCNPAMHLNINTQCENKRTIDVLRARCEHRQRCVLPVNWATFPVDFGGDQCLGTPKYLDAVYGCVRGEKNECRVQANVEVFGDICNDTSKYLEAGYECVPTKVTTTTSTTTLSTIAASAATTNTTAIVPKGAGDDVGRNGPTEKIITGGCSARQERELNWPTTAYGQTVRVACPPGTRGHADWHCSAKTKRWTPMDGPNLAKCISDWARELREDLEDETGLESAHERRVAWLETLRETYKQVRRAERLFGGDARVVAELLAGMAKKGRDRAFGKGSATAASMLDVQQQEKRTKLQQEMLEFVKLIIDTIGHLLRSNQRPAWIDLSIDQRRHLAAQLLQTVPQTLALLLPLPGWPKSGGSESLLAEPTLITEVAQASIYDYVPFPSMSLYRQDFDTVLLPREALHLYGQDLANVFYTAWDHSMVNFLLGNNNGTFPVHHRHPRLVQTHAIAKLVGFAVVPMNGKLIGPRQHRISLQRPILITFRNDDPSLNIPHRKMIGEPRCAWWDSDNSKFVVTNTEQLEPETADKLASAAGADAGCTLQERNRTHTVCECRRMNTHFTVLADFEDGMTNDAVDGWDNNELPFSSAFVYAQFRLGALIALICLLIGLLITLLMKPIRSKGEPIKYAMPGCHPSMDRCHITATLLLIQLVLLNAFYGLQRQQYICTPVALVLLYLVLAALCWTLLDALHMRAAARRLHAAIETISSSSLLKLFSIYLFGYGFPLLLIVVTFFIQNLHKNVPAQSLLPTAFCWLASDFFSIYTFVGPVLLLLSATILCLVFTICAMNSTRNTKSSSSDAYRPCANGISQHKQREQRRRRVQLRQRVQWLCTRCALLCAACSVAMCWAYFVTLAMEDGVVMASSMALVANSAMALALLNAALGVEMLAEIVVDKRSRAYYRRWRLDGGGFGTISAFFTNVVDKICCCGTFVVKKAAQNGTGPEFPQLKFAFSPSGAVLLENVNGCGPNSSGTSSSSGRNGGTASACSEISTTELPVSSSDERALQAQHSQSQRAPPPPAALLQLYHEHHRKNSASSNSRPNEFASSDNATYEEYATIPYDDRLSLGKYPINAPGYRIHHPAQSPLYTATSLAQPIGTTPRLTQQQLQQQHKLLYGGGSYSARGYLGNNYGAHAPYTPHIVRMQQNQVQLLHPDLPMHDGTNYRHHMMLDEHNQPIMMVVDVPPGEMGIHSVPPPRIPPPPTPAYAMNASVHLSHPSFYRGSPVMTSARGSSSGTLVKMDLSRPEPVFSERINSLDEGEEEAEQCVDGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IH33</accession>
    <name>A0A914IH33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IH33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9833.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9833.t1"/>
        <property type="gene ID" value="Gr19_v10_g9833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9833.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19358" checksum="BF7362D23F883D37" modified="2023-02-22" version="1">MNASGIFCWTANVPQMPTPTTARPLLAAPGPFIAGRRGQKKAKNGRGKIDKMDKHLANLNKQRQQKCGSQNGGKDGPAWAGQLSTTGGACRRSPSSDPDNSAPAGIVCMFFMINGTLKLSWTVSATITILNRPCRVGLSARLAAERRGVGQGWESRRKKANGDSRSAICPKKAIIAITIARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPF4</accession>
    <name>A0A914GPF4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10121.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10121.t2"/>
        <property type="gene ID" value="Gr19_v10_g10121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10121.t2"/>
        </source>
    </evidence>
    <sequence length="342" mass="39340" checksum="A0885A2A395EE518" modified="2023-02-22" version="1">MSDNKSDEEQQCDFICADVWHGVFAFLDPFELGLKVALISDRLDVLVDVHFKSREWALGWLRIVRAIGGNGAQIVKRYGAERLPIPQGPLPKNVIGFKEIKIRYVDQTVIEFLQHISRLFNSPGTTVYIKNDDDQSRSWEIIWQKIWPLIKDNICGFPLYFFSKFDRLRQFCPAILRNCANLRSIESSGLFPEFPAKDNAGASSGQALAKWLLTSREDGLPKVLYCRFYSTGMDGLKGAFVNALEPVNFIIRLHSIVGTVPFVRENNWTGERLTFRQIDKNEWLLVRCQIGRKEAKWAVWEKEAIEWKGYNQWNRRIIISFEDSDIGDGMIDANEGPNELTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPS5</accession>
    <name>A0A914GPS5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPS5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10216.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10216.t1"/>
        <property type="gene ID" value="Gr19_v10_g10216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037409865" evidence="3">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10216.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20464" checksum="2082D0653C7C85B9" modified="2023-02-22" version="1">METITKMIAVVMLIVISWTEEAEGLKCPKQFIWNKAIRPLELAKYAANIQKDWNVTEKYINEDCNDHCLSFTCKDKNSDSKWATFGCASSRKEGQCVESDLRHCPESQFTSVCHSCKQGDNCNQNHIDAMKATTTTTTTTTTTTTTTTPTPSVEMSTAGGEVSARLSAIPVLLLFGGMLLFHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ99</accession>
    <name>A0A914GQ99_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc metalloproteinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQ99"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10425.t3">
        <property type="protein sequence ID" value="Gr19_v10_g10425.t3"/>
        <property type="gene ID" value="Gr19_v10_g10425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10425.t3"/>
        </source>
    </evidence>
    <sequence length="172" mass="18486" checksum="C76D5929C2E24E27" modified="2023-02-22" version="1">MCCKSHISEMGMLTTEGPLATASVYSQKGKRTFILSHRTVSPSDAPLYTKWSVSAPPVNESFFYPPPPENPPGECFDWSPNCASNKNACAADRYRANMAKLCRKTCGLCSGESTFGFEATTPEGMKDGNCADLAAGCARIGYLCESGSRALGMAILCEKTCGRCKGAEIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS09</accession>
    <name>A0A914GS09_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10231.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10231.t1"/>
        <property type="gene ID" value="Gr19_v10_g10231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10231.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47865" checksum="442561734BDA09A7" modified="2023-02-22" version="1">MQIAFGSVGFGVFNLFVQYINVAFPRKQNEMRNTVFIALRYTSIVQNCYVATLSLYGSTKQSFLITTIVVATFLCFVGVCIIAWAFYNRCKWCRKFGLKQQLKQINRNFRHILVVYFGIFGGLYHFVGIDNLLAPFIAVVSSLLYALVYYCIAKNSIGEEYSKAPIRGQAPDSDDYIQQMLNAGLEKGGDGAEQHESLLVWLLLKECEIVENILDNELKVEVGRNCTALKSGKPLNSQNGPKMVAYLKRIEKEKQITVDGQQFVALFNILRQLVKEMSAGPAKDAIEAVFKQKLVPMPPSEMLQFAIQIWHIHSNNVHGHPQKRREHPRRRRKRANGESLLINSLAFIVVWFITSKLIIGSVKSGLSAIDETFKEYFYRIVFGIAIILFFLFQNAQNGQGQSFQRAIQSILSKLKNRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTP3</accession>
    <name>A0A914GTP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Basic leucine zipper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11124.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11124.t2"/>
        <property type="gene ID" value="Gr19_v10_g11124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF44">
        <property type="entry name" value="TRAFFIC JAM, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Basic leucine zipper" evidence="5">
        <location>
            <begin position="170"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11124.t2"/>
        </source>
    </evidence>
    <sequence length="371" mass="41159" checksum="4447D6578B970F81" modified="2023-02-22" version="1">MEATGSKVAPSSASTGELILNCGPQSCELAHVQKEMAKSDLSSQGVFVAHFLSGLSPENVPHQPTPSTLPELSSSFFSSGPNLTPTALIPPTKHFDQLEKQENSNGYLMNQWNRSFVPPEVNQRLLSSPESVESSQSFPLKNGKKQSARRSLSSELERSATDAGAVLMADWELTRLTVRELNQRLVGQNRSVVSALKQKRRTLKNRGYALNCRTRRMRNQQQLEAENVYLRQLVAKQSALLAKYEQKLVGRETGKADNDNVEGGSSEKWPEEEGVSPRQNNNASSPVDGAGTSVKSLTNSSSAQMPTAHFRQYNGTVNSSSPQQQELFYPIVYQQQQQFPTTELQFPYYPVFRGNGAQEAAAQFQNWNQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUD3</accession>
    <name>A0A914GUD3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUD3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1129.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1129.t1"/>
        <property type="gene ID" value="Gr19_v10_g1129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1129.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15367" checksum="07D239DCEAC96CAC" modified="2023-02-22" version="1">MENATESDGAGRSGEQEDSHLVPSSDAKIAGGEAISEPGKGVERWLGETLRVELIDGRVIYGRFVCTDNVPNIILMDSREFWMFKEDEAGGDRTRIPIRRVGMVLIRGEHIKRIFHIVLPDKETNAKRTEEEWKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV64</accession>
    <name>A0A914GV64_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calreticulin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV64"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1108.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1108.t1"/>
        <property type="gene ID" value="Gr19_v10_g1108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1108.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10649" checksum="12735596A5FDE612" modified="2023-02-22" version="1">MAQKRIFKRANEKAPAEEKSDFCGGPDNWTVDNPTVDNWTVDNPTVDNWTVDNPTVDNWTVDNPTVDNRTVDNSTVNEFFKLDKKIFLRIFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVY6</accession>
    <name>A0A914GVY6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVY6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11270.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11270.t1"/>
        <property type="gene ID" value="Gr19_v10_g11270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11270.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="18307" checksum="902D367E4F07B8C8" modified="2023-02-22" version="1">MVVIASRNILAGVPEGGASAVMRSEVPAPYPLGRSRSLSHYESQCGPTVVPIGMPSKPVGVYQPYWTYSAYWPNRYHRNYNTYDNYITDSFYWHYPFRRWSSYKHNWYHYDSPYYYRRYHDYYNMFYNTELLSYGNRSKMMENLYQETPITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW70</accession>
    <name>A0A914GW70_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW70"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11753.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11753.t1"/>
        <property type="gene ID" value="Gr19_v10_g11753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11753.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8141" checksum="4FBD0F6D6ACB2CD0" modified="2023-02-22" version="1">MLKPGQHNSLVSLIVEDGAHHYDLRGEHPADTESVREVAHQTLDCGGARAAARAKAHGARAHFACRVCIMTLTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWB0</accession>
    <name>A0A914GWB0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CMP-sialic acid transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWB0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1193.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1193.t1"/>
        <property type="gene ID" value="Gr19_v10_g1193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1193.t1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38081" checksum="6E6DD31DFFCA263A" modified="2023-02-22" version="1">METATSQCDAIAVGKRGQRSELRDCFFKCYVVVLAVFVWTGYTLLVAYTRQKTPKSELYSSSTVVFFSECTKLAITLFFIYRDCDFSITAGKKLLDREYFSKPLELLKMSVPSIAYALQNNLDFVALSNLEASVYQVTTQLKIPSTAVFMMLFLGRRFSMKRWVAILLLCAGVASVELDSLESEGQIGTKSGAGNRFVGIFAVFATCVTAGFAGVYFEKMLKDGSSTPFWIRNLQMYSCGVFSAFVGCFLKDYGHIRENGLFYGYNVWVLAIVLSLSLGGIYISLIMKHLDNLYKSFASSISIVAVTLLSLLLFENTFIGTFFLFGALTVCFALVLYNSVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWF4</accession>
    <name>A0A914GWF4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">T-cell immunomodulatory protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11821.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11821.t1"/>
        <property type="gene ID" value="Gr19_v10_g11821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036926495" evidence="9">
        <location>
            <begin position="28"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="496"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11821.t1"/>
        </source>
    </evidence>
    <sequence length="651" mass="71368" checksum="D7A2C3A53557E6C3" modified="2023-02-22" version="1">MVNCWLPMPEKMPKSLIMSLLASLSAASIVNIGDKPMLPIAGRICAIADMDKDGNTDLLIQQNNMLLIYLQPNDGSDFRKSAQVLTLPTGVGKVSCAVGDFNGDTCPDLLVVQTFQADLNIIDKVKALFSAAETQYAAVLYLNDGNNTFTEHQICDENGLEGTASPGPSPPTPLNCPIKFVDHPTLVDINGDGITDLLGFALRKAGDGKEVTELFCLQGVRHQSPPGESVEFRRCEHLFPPAPVGGVFPGFTPIFADLNSDLSAEFVFLEADKRKMVVWSQSSAGPGAASEWKVNETLSVQLPALGEGEALASPLVSDVDSDGQLDILVPVCASAKCNSVVRLWCYSRLTVRVVQIDLRQVTLEPEIDGQTIVPFRIGDFSLNGYPDLIATVTLPGGSSRTPMIFENAPDDGGYQRKFELTRKPQRILPPLNDKLSGLVMSAFFDLKEDGNLDMMVEYADEATGSSVNFIRTQCIGCCKPQQSENANGVRQIKIGSGIVWHGACVSIQMTDFADQSADGLRRIELCQLPQSAHRLLHNPFVLFGLSRTPNFVDEVEFGGPRLIIEGRFQRDLIRQVVPNSRVVVIPPDSETGHWTSRLFVTPSQLIFLSLLVMATCCGLLLLMITFLHFRERQQDKKERQAQTHRFHFDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXC9</accession>
    <name>A0A914GXC9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC domain-containing protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1163.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1163.t2"/>
        <property type="gene ID" value="Gr19_v10_g1163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000044">
        <property type="entry name" value="TBC Kinase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF168">
        <property type="entry name" value="TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="432"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1163.t2"/>
        </source>
    </evidence>
    <sequence length="683" mass="78011" checksum="50BFE77374EF269A" modified="2023-02-22" version="1">MKFGAVILVGNEVRTDNAISTSMLGRLASIASISHDNLCRYLELIKCQTIPNGVIIVSEHYSAQYCRVQNSFKNSIVIGSLSIENILFRVSNEQVKVKLSHFGLYYISEGNEAIKEAICLPWYLSPECVLNAEEKLSYCSDIWSFGILLIELFTGWQLAQIWSRKQVMSVLRSVVFKTKHGSCLENLLDSVEISCPAFKSSSHCLQNARFVSEKCLQIAPMDRPNSTDLLQLLDEANQQDGGHDACECPCAEASIDESIDSIKKRILGEEGLAKFGFTTKTVNEVFFLWKLCGSSVESILIRNGIIQNRPPVLAFPRLLVDDFRLYGNEKARKVNLALNVAELPLNNLLERLNSIPRDELYLSLDWIKIRGCGQGNESKASLSPPLGADSVQSLVVKERDINYQFKRMRLFRRFLSAFPYKSDLLRHECQKDIPPVYRGAVWASLLDVFPAFDDGVFHHEDFCQIDTFSEHPSDRQLQVDIPRCHQYDELMSSPMAHYRMKLLIKTLLVSRKDDDFVYWQGLDSLSAPFLILHFNDLSTAFRCLNAFIERYLHGFFLQDNSTVIRNYLAEFMRVLEFVDPELFSHLISLDFHPELFAIPWFLTCFAHVLPLHKLFHLWDSLLLADSQFPLFIGVAILIQLRPRLISVNFNEAILLFSDLPDLPIDEIVQVAKMHYGNWLVSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXM2</accession>
    <name>A0A914GXM2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXM2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12134.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12134.t2"/>
        <property type="gene ID" value="Gr19_v10_g12134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12134.t2"/>
        </source>
    </evidence>
    <sequence length="276" mass="31304" checksum="72C76CD4DA396906" modified="2023-02-22" version="1">MLLLIKISRRRTGRAELAGPKTGRRRKNRAELTPTVCGRNVEFWLGEMSAPKRRAQTARPNTFSTVKIEMNFEYVDLKYELMFTSVGCACRPNTLGWCNVTSYILYAAQKDICIAGLDEVSAQYRLLETVEKAHSSEITFLTLSMATVVNAESEVYSLFCSATSSGELAIWKLRKTANDRATLIRRMKKDSNIELAKMGLFNSDRTQIVLGILQFDHIDVHILNLEDLWRACYGRRIVFWDGGSLCRGTELLFLPKEAFSRLVRQQIVGSFAGIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXM3</accession>
    <name>A0A914GXM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12300.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12300.t1"/>
        <property type="gene ID" value="Gr19_v10_g12300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="381"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12300.t1"/>
        </source>
    </evidence>
    <sequence length="578" mass="65055" checksum="8A574D33FF65436E" modified="2023-02-22" version="1">MNSRTSSSASFDLVAQNENDVTDTLHGQNNKIEPTNDKESTADQQEADQLEGMVQQLNGNESAKMEELQKQQQHNIDESAKMEELQKQQQQHNIDESAEMEQLNVDHLQSDQKALLERRQQKTDQKAPIDQGTSQLIEECQNQQQQNIDALTEAQKGNVEIGGKMGKIGNLVAILTSAGQWRRYDPFRIVGAIVLLIFIIYAVHQLNAQKDYRFKMNEQMNEMRLEMAESLKSVQAMVGAELGIGNFSMAAHEEEEQTKLEELKHLREEIKQFELELKGMKEIGKQFNASMAAQEEEEQTKLEELKHLREKITQFELELKGIKEIDPYRIAGVAGAIVLLTFVIYTVHRLNAQNSIVVAELEEQKQANANKFAELEGHQNQQQLNIDALTEAQKRNGLIPQQNRWDSSMCHKDLALSEPDPLIVKKKREANCAVSSVLAVEPIPKEFLAFPTLNGDILIGLANKQMPLDRYVGLHDGTYAYGNYGTFWGHEVAGCSHNKNGRRYIYGKPSFDVGDVVGCGINLATRQIFYTKNGECLESAGLFVSFAADLFPCVSLWGSGVNSAEIEANFGPNFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY06</accession>
    <name>A0A914GY06_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L23, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GY06"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11422.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11422.t2"/>
        <property type="gene ID" value="Gr19_v10_g11422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11422.t2"/>
        </source>
    </evidence>
    <sequence length="161" mass="19367" checksum="05ECB53E24C7A300" modified="2023-02-22" version="1">MTTRIPRLWQPGCSRPRVFLPDFCIKLVEQPKRGYKRIPRNAAVFEVDLRMSRLDIREYLEKIYKFPVRDVRTYVKIGDITWDYPKDVEKRKALWKEEDRKIAFVFFRVKDFIAEIPDLFSGQGSDEEINKMEKYQEQDLNAFNRRFVNRERAGIGEMLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYE0</accession>
    <name>A0A914GYE0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYE0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12294.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12294.t1"/>
        <property type="gene ID" value="Gr19_v10_g12294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="475"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12294.t1"/>
        </source>
    </evidence>
    <sequence length="686" mass="79346" checksum="2E607AD0E5DBBABE" modified="2023-02-22" version="1">MNSRTSSSASFDLVAQNENDVADNLNSQNDKIEPSNDKESTADQPEKEQKKSDQLEEMKQGEVMEEFKKQQQHNVDESAKMEEFKKQQQHNVDESAKMEEFQKQQQHNVDESAKMEEFQKQQQHNVDEPAKMEEFQKQQQRNIDESAKMEEFQKQQQHNIDESVKIEQLNTDQLQSDQKALLERRQQWSAPIDQGTSQLKGERSAKMAEEYQKEQQHNIDSLTEAQKGNDLFRIAGAIVLLIFIIYAVNQLNAQKDYRFKMNEQMNEMRLEMAESLKSVKAMVVAELENGNFSMAAHEEEKQTKLEELKLLREKIKQFELELKRMKEIDPYRIAGAIALFIFIIYAVHRLVNKFAELEKQKVSNANKFAELEEQKVSNANKFAELEEQKVSNANKFAELEEQKQSNANKFAELEEQKVSNANKFAELEEQKMSNANKFAELEEQKMSNANKFAELEEQKQSNAKKFAELEEHQKQQQQNIDALTEAQKRNGLIPQQNRWNSSMCHKDLTLKPDRLIAKKKLDADWELIPVFPLTFSSVLAEEPISKEFFGISYFEVKILKKDGEIQIGLANKEMPLDKRIEEHAGTYAYDNYGRFWGHEVAGCFHTRKGRPYIDGKPWFCVGDVVGCGVNLATRQIFYTKNGERLETAGLFVTFAADLFPCVSLYGCGSKGVKIEANFGPDFKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYX7</accession>
    <name>A0A914GYX7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g12472.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12472.t1"/>
        <property type="gene ID" value="Gr19_v10_g12472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037941780" evidence="7">
        <location>
            <begin position="20"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="7"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="732"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="793"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="904"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="958"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="960"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="974"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12472.t1"/>
        </source>
    </evidence>
    <sequence length="1706" mass="186357" checksum="54D321FFBB7158EF" modified="2023-02-22" version="1">MMPTPKMLAIVALVSFCSNWQFGYQITYINTAHWSFFSLADEVYMNSLSVSAPCASFLFYVPRLIRSVGGVRNALLLSSFPAVIGCLLQLAVRLSKTLPTLCLLLSLGRLLVGAQAGCSLCLLPLFIIETTPRHHRPFLSSLQVVFQSLATLIGLCAGSDHLVSLGEHKIEWLQIIGLAPTMFFAVFLMWLPDTPFRLLEKCQKVLDFDDNDDTFGEDVELKFELSSLFYYGSNADFGAIRSEAFERWALPPEGRKRRSKFVENWKGLLVGIFAAISFAFTADDLIDSYSADFLYRFSSVSPSPKADAEFLTAGLGLLLFFTSIFGAFLADRFGRRRLLISGLLGTAVSNAIAAFGASVDSASTVAIGFALTKAFIGFGAGAPAWFLTSELVSPLYVAQGQAISTGFLLIATGLCTLCFLPIQDWLGSADALLALSSVPALFIAVFLFLMLPETSDFSPVQIRHILSRQTLPGLAAHPRFRRLLLESESEAVPWERSWELPHRSQRLMGASAYVSYGSMRSGLNTPLRAHHPPRLSRRHSVEPFDQHRNKSFNSVSHTLNTLKRTSDASETEPIGLFRLFRLRQDRPERHYSPVAAARRPLTASGANVALVRLSQLNGPPPLKAQSQPKPEKPKLSPTGQSPPQQNLLLLSTFNVPTMKRAAAAAIFGTLIAASLLFRLADLLDVHCDSDEDCSSPRVCRFVCRRNCKSVGVLLAAGKDALASGMDSLDSGKHFLGTPGRQMAAPKRRKMHRKPTDQSAEDEAPFLSGKNPFSVGKMKEVTTPLTISEAELEAELRQNGSKEEEYDETPKGPSDFVTAPTANILEETDATTKRSSPPPPPSTSSEMHNFRETLTPKKSGTISEVRGRGRSPSPHLMTLSTSMELLPGENEQVKTTTSMRMIRPKTTTTAPTQIEDSEPPGISPQPPGFTPIPTSSSSTTTATTTVTEDSISATIAAELNNELTLPPSDQTQTTTDRKKSSREHYSGEEFIEMKKGKSGSDSFGGKTKFWPPLKLATSSASSSTSKPFSKTSQHKMTTLRTTIRNCPNPPVCLRNCGIVVDGDGCQSCQCLWISKVCDTDLDCAFTEGQFCDLGRCECADGWAQDVGMSGVCRKKQNAKLRGVPLVENALGHDQKGYPSDHSDQFALRLSTYPTKPFSDSDILSPSILSQSVPPKRQMLTEKPKREERLQWPGPCDSDDQCPPSLFCVEGDCWTLEAVKANERQRNANEENASESKMPNFPLPVPIVPVNRPQKEQSLLFPHFEDITAAEKPLGTETAVDYDDDEDAQSADNATTISPKRFPMARPTTALIQTVQTLRFSTNSFATTHKQQHNHSNQNQTMLKSNHNKQHHHNNPSLINNTTIIPTRSNSTFSIISITCSSINNTRTTHKSNSCPSSTFVGITTSGSTFIISNTATSSCTPTIRSYTTILYVSNTTYTSTTRSSTTSVSNTTTAGSTCCTVSNTVTAGSTCCTVSNTTTAGITCTVSNTTTAGSTCTVSNTVTAGSTCTVSNTVTAGSTCCTVSNTTTAGITSTQKGLQKIPNREVQDDVHLAMTSIRGTDLRHHPLRQSLPWEGIFPEAITPTILPNESTIGQKTEIGIGSAVKIEEIVNLDKVRRRIFLDYSRQNRLSRPIRVEHKNSKELIKDECEQSRDCGRRHFLCCAKRWCDLGGDCGMAKFCLPSCELTKLAHLSELSPEGNPRMDLVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZF5</accession>
    <name>A0A914GZF5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12766.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12766.t1"/>
        <property type="gene ID" value="Gr19_v10_g12766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12766.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28364" checksum="5466F9707054B75B" modified="2023-02-22" version="1">MDQSTLLPEQKLEKACNDAATLCQCGWARCIETDGFKASLCCKETFQFKCCVDPDQSFKLIKKNTVTFCYGTHPGTSREGRMKTANLTYFCDDKPLHQKKPDRNPSKHLPIPHAEPPQSTTNSEICAVPPSQPIVIAASSLHSRRSFAVASLPFCSPDSAGKPSILHRPKCHRISRTHSSAFRLQRDRSLHWNTRRPKPQLGNNSREDLASDHDNICGIFLGSSELFRLRQFGVTYNAILCALKALTRLSSFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZR2</accession>
    <name>A0A914GZR2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZR2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12854.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12854.t1"/>
        <property type="gene ID" value="Gr19_v10_g12854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF35">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12854.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22745" checksum="4C264F71B487DACF" modified="2023-02-22" version="1">MSQIVDVTHDLATDLWDWPLQHEDGVVQVHNGHDCWEVALDAAFFRPDEIEINLSGDHLFIYCHHEERVDEHGWVKRELHRSYKVPEDVDTGTIRSHFTPNGILQLKALKKHAARRPSINVAVIAEEEPKKEKPKYGAAALAAQKPGKKLVVEVENAKIARPISPISPRENLFASAANFCSTQMPLGPFGWSWYNVALIGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZS4</accession>
    <name>A0A914GZS4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gelsolin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZS4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12617.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12617.t1"/>
        <property type="gene ID" value="Gr19_v10_g12617"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000005">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF123">
        <property type="entry name" value="GELSOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="273"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="347"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12617.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51584" checksum="780B84C5C37E5754" modified="2023-02-22" version="1">MVVDPKLKGIGKERGIRIWRINKFALEDVPEQQYGNFYSGDSYIILNTKNVGEIGEYDVHFWLGKRTSQDEMGTAAIKTVELDDSLNGLPVQYREVQDYESSLFLSYFKDGIKYLEGGAESGFRHVVPPYQNWAPKLFHCKGKRNVRCTQVKCVKESLNLGDVFILDLGLNLYVWMPPMSGRLERIKGMNQAKSIRDKERVGRPKIHVLDQDWDSNEEFWRHFGGKQMVEWIKVPKAGGDDDEYWRANRENITLWRVSDASGKMEITKVSQGGLNAVDLDSKDAFIVDAVSGGLFVWVGKGCTMDERRKAMDWGQQYLTQQKRPPNTQIIRPKLYQCSDETGKLRVEEIANFYQEDLDGDDVMILDGLNTIYVWIGSGANNQERDGAKTTAKKYLETDAVPRHKKASIEVIWQGQEPPTFKKMFPNWDDKLFANKVRSYENMRKLLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZX2</accession>
    <name>A0A914GZX2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZX2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12653.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12653.t2"/>
        <property type="gene ID" value="Gr19_v10_g12653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12653.t2"/>
        </source>
    </evidence>
    <sequence length="356" mass="40983" checksum="5C2B5645FCB9E08B" modified="2023-02-22" version="1">MSDNPKKVEKRLKELFVCDDVLFEVFKFCGHFVLGLKVALISDRFDFLVDAHFKSMEWSLGELYICRAVEGTGAGIVKYVGNKVERQLPIPQKPLPDNVIGFECLRICYIDRSVIEFLQSIRRLFDSKMTILCIGTPYFQNRSWEIIWHRIWPLIKDKICGFDLDSSDLDYLRRFSPTVLSDCAKLRLIKSVYLFPAFPADDSASASSAKALTKWLHTPCGDGLPKVAECRYCLEALEVLKREFVNSINPVNFIICLWNRASEIIVPFELKNNLTGERLEFRHFEKDKWLLVRCPLERDAVKRADCASKCNWIHINFIINFEDGDIGDGILDANEGPSEPKKRRNLDKTIQNEGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H033</accession>
    <name>A0A914H033_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H033"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1295.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1295.t2"/>
        <property type="gene ID" value="Gr19_v10_g1295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22042">
        <property type="entry name" value="HMG-box_EGL13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000003">
        <property type="entry name" value="Putative transcription factor SOX-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="824"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="824"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="648"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="918"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1295.t2"/>
        </source>
    </evidence>
    <sequence length="1082" mass="115498" checksum="C9D10E662501E177" modified="2023-02-22" version="1">MSSRRKGAPARRLTPAALASSSPKSTSPTPSTQPSASSPASFPIEADDPLLLEQASTSGETEKMMDCSTLLAHMAAVQQQHSHPTTGPGEQQQRQENGKDTAGIEAKLNGNGGTAFDEKGFSSIQHHQSPSVMVRNGPASGSSSSSASSMDFDSSAIDGSPPLLRPMLPFAGIMGPVGGHGGSSPSAPRPFLLRPSGSLPPTEEGDSSGASSPPGTTASVRSNTSSQHTSTSTTASSPHLHHHGGGNNSSTIINNSNNQTDNSQNNNYQQHIYRHHFQAVHQCNNQQQQHNQPEGSMGGETMTAIREGGGSCPKNAKNGGDEEEGEAEEGGNIASILSSLPGGETFTQALMERHGKHAKLALLRHAIDKLNCVSERLTSSLEDADEESANGWVANRKKMDEEEVDEEEDEEEDERLMMIVEEMGDDGVQFGEEEQKQQRKKLKQFGGQKGDGRDAEHCGDSLAAEREEGEERRGGRNGKSNAEGHEGKEDGEQVQFRQQMLTPRDHQQTMMELLERQQQQFNNYQQRPISAIHHPQPQLTGMHPHHRNHHHHQQLLAAAAAAGMPPALASVLFPNDPSPSLDLLAAAAAAGAHPAQAQNQQQTALARQMAATAAMLGFTQSPPTAAALLHQAAEFPSVHQFFNGNSSQSPFSRQFHPMPLNCSTDVSPQLSTESAQPQQHNHQRTPTTPKGRKRRQTSASPAAPNGGIERNQLTPPNLLGPADSPLNLSRLKTESGEGSHNFDLLPNRMHSTHPTSSADAQISCSSSGKNSPNPMNNCPNNSANSEKSIGDKFEAKSANNCNKKSSTAGGGGQQRPGAKSPNHIKRPMNAFMIWARDERRKILKECPDMHNSNISKILGSRWKAMSNGEKQPYYEEQSRLSKQHMEQHPDYRYRPRPKRTCIVDGKKVRITEYKSMLKGSNNGTTAAKDASQKRQNLSASTTPAEQMGGGGGGTFDTAPLSPMAVSEESNESPVTAGSLPAMLFTAPTNGSSPPVKSLMEHQLAGQFAQNSALAAAAWLSAAAVSGGGPRGGAGGVSALHHAMLLADQLHHHPTMSLNFGPGVATTVPAQPSQQQQIANLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1A5</accession>
    <name>A0A914H1A5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Matrin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1A5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13106.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13106.t1"/>
        <property type="gene ID" value="Gr19_v10_g13106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="968"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Matrin-type" evidence="12">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13106.t1"/>
        </source>
    </evidence>
    <sequence length="988" mass="113884" checksum="932674D3FDDE5DF8" modified="2023-02-22" version="1">MESLLENQRNCHEERERCVDLMVKEFTMDKKSQRERINSDQRVNRLLERNQIATQKLISAYQDEHGERSKEIQAIGGPNEFAEFYSRLKTLKDIHRKNPNDTARTLTIEFQEMANFVQDPDRVEKEMVRFMDEEGYGKFLDLHALHEQFVNLKGINRVDYISYLSKFDHLHEIHKEKTKKSGAYKSYIVSLEEYLKDFICRAKPLIDIAGELERVDKDFEQKWKEGKVIGWSNEKSSGALTKFAPSSAEVDLSNFNSSEELEELGADRLKAALLALGLKCGGTVKERASRLLSAKISNVSSNANGKGITEDAKEESRKYNLAKIESRVLRLSELVSAERAATRENVERKQARAVGEEEEEDDVEEVYEVEEEADNVPYNPKNLPLDWDGKPIPYWLYKLHGLNIGYGCEICGNQVYKGPKAFQRHFTEWRHSHGMRCLGIPNTAHFTNITKINDAIELWKKICDDKNRNKWNPEADEEFEDSLGNVVNRQVQTAIPIPLAHSFVDFVAFSPMWRRLSILFCLLLCLCSSQKEPAGQNLILLLVDGYGANLFNQTDSRTKSGTRTLLENGMEATSLKPVYPTQSYPNWFSLATGLYVESHNFTSDFMFEPNSSMLFQRDMGMNDSNPFWWTGYPAPLWYAVGKAGIDVHCYWFPACHKAHVDLIVQVPQNRRHSFNNANKIDLLPHLPTIIKHIKKYQPYRQQLVLLRYNGLDEALRAGGQSSSQTRQALSTVDTYIRRIQEEMDTMDLHQSTNLIVLSDHGLMAVEEEDQFYVEECLADFSMVRQVANSLAFTMIWPIDGEEDTVFFELKVCDQWAFVGDYENEEAAPLVSVYRRHELPEHFHWRDSRLVAPIVLIARPGIVLLTRNLPSTDVSEKLAKEWKMLDGWDNEHEEMQGIFMARGPAFKSHYKGEEQVEVVDIYQLVLNILGVEPTHFSNGSWNRVADVLSEGWEDRRYEPQSFALRHLCPFSFISIFIVTLCFWSIAIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2V0</accession>
    <name>A0A914H2V0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H2V0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13476.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13476.t1"/>
        <property type="gene ID" value="Gr19_v10_g13476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="299"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13476.t1"/>
        </source>
    </evidence>
    <sequence length="640" mass="71851" checksum="75B298A95D014C21" modified="2023-02-22" version="1">MGPQSRIFGGCAGGSELSKSITFHDFCELTQREMGELKLSSPKGRIEEDDEEGEAMDEAEEDEEEEEDLTILEPTIQTARVPPSKVPKGSSVLPRWHSSSTDDQDKGATKTAPTKRRRRPLNATFSDWLQLFLSKRRHRHNRFMNVATGTGADRSRMMHQSCYAGMAGPNGGPLRSSVSLSVVHEINALGSDGESIEVSPCTSDQSAGGPSGGGTLTSVADGRQTTKAEYIPKVKLRQKPNRRWSEQDIQKRLSLPPDIRLPQNVIDKLNRTPTLDNPLTRKSKRASLNEIGFGKLETYKKIFDLGEGTYATVYLGKSLLTGKNVALKEIRLEHEEGAPCTAIREVSLLRNLRHANIVTLHDIVYTDRILTLVFEFVERDLREYMEELDGMISIANVKLFLVQLLRGLAYCHCRRILHRDLKPQNLLINRAGELKLADFGLARAQSVPTKTYSNEVVTLWYRPPDVLLGSTDYSTHIDMWGVGCILYEMLLHKPMFPGSTSDEQLHLIFQKLGTPSPIVHPDLCALQTFQNSQFRQHNAKPLMNPPRINPERADLLHKLLKYEGKYRISAVDAMSQPMLNCFPAQLFSLSDTESVLSLPGVHYIRDSKDEAYMDTRMTTGGRTDRPAGPRTRLMNHCEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4I0</accession>
    <name>A0A914H4I0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Death domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4I0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14081.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14081.t1"/>
        <property type="gene ID" value="Gr19_v10_g14081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14081.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25378" checksum="8BF2D064AD815367" modified="2023-02-22" version="1">MIVLFDATSSKSTEIRHPNSPKFWHQLMQETGISNKQIEQMASEMDKSDSFIEKLSNEENYKPPRQSPKQPAFELKHPGKQSLFLTLLKLDNFYELVGRQEKIAKLVQDLAKTFINIKKLPEIVQSLATIWSEMRRINNGENANEIVQQIVYLWQSVKQNDEFNEYFGNKSEGKNRRTKRRILHGHSGHGLVYYLISAGIIVVLSILVLILYCWRKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H544</accession>
    <name>A0A914H544_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H544"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14077.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14077.t1"/>
        <property type="gene ID" value="Gr19_v10_g14077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14077.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11450" checksum="834398A9E19FCFA3" modified="2023-02-22" version="1">MLNVSETATNRRIGNSSVHFSCTHPTIWHFINVLRTEQKSRDADFARFVMGEEPPKKAEKFRRADAQILRLVERYDPLNIVEMLPGISRCYVMDPEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5C0</accession>
    <name>A0A914H5C0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5C0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14303.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14303.t1"/>
        <property type="gene ID" value="Gr19_v10_g14303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14303.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22052" checksum="06438E20EE955E20" modified="2023-02-22" version="1">MASIAEAEEEAICLALAEHIAAVHATCSGAQVLLLNKNNGRQQRLEEQMMLNRMGEDGQDGDKMEQDSKEVGKDELYEAELFGLLRMADVPRENDDDLGDDEGNDEDKQQRISADKQAELRDWLSEFLPLARANELSEREIQPQDVRLLNQLMEMNSLLHDDFPMLDSRRSRNELNDRRVVQQPLRIGALFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H732</accession>
    <name>A0A914H732_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H732"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13826.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13826.t1"/>
        <property type="gene ID" value="Gr19_v10_g13826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00698">
        <property type="entry name" value="TMPROTEINSRG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13826.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40135" checksum="19110A8D6281FE2D" modified="2023-02-22" version="1">MDFAEWSISVKIQIIYLSICISIPSMALYVAEIVTIVRHKKFHNSFYALFVMRAIPDLVYVLASFYCNRLPSIIGSLLYPIYSQLPTWFYAISLFFTGHTFQANNLVTIFILLNRLTAIIMPMKHEKLWHKFLPFVTILVLCVPTLTCWPILKLDGIIKLTNPNSTTDRNFVMYEAGDAPYINYLTYIYTVFSAIFMIICLLLNVCTLVAYKLNVKKVATNGNINGVEMEKKLLIYALATFLGHLLVASLFLILVITNFDDPKIRAMQLVYYPVLMDTGTVVLSSSFLLWASSTFRQQLLKDFAIIRINNVQNNRVDAQEGPRNNNLWAIKVSHQVQTRFSSSVHQLPTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7R9</accession>
    <name>A0A914H7R9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g14598.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14598.t1"/>
        <property type="gene ID" value="Gr19_v10_g14598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057329">
        <property type="entry name" value="Beta-prop_Rol-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058726">
        <property type="entry name" value="Roller3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25494">
        <property type="entry name" value="Beta-prop_Rol-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26432">
        <property type="entry name" value="Roller3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2126"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1724"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1843"/>
            <end position="1951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14598.t1"/>
        </source>
    </evidence>
    <sequence length="2162" mass="238711" checksum="1FAE94F8A9601A97" modified="2023-02-22" version="1">MIGVQFVLINVLISLYGHTLCFATIFSNSLQLCYDQCIDRNLALPLPTGSLVWHNISTTNCDFDCLVDACRSGCKDLESLNSTCDLRCNSIGDGSAACHQGCRAVADLFLHQLQQLVELVSVEAFLDVGLGVGLNWSFSDQQATIIQEISTTNIRWMALSRASGTSTGWRWTPMEEKTFREPNVQLHATIFVPMEQHSDIELQLVALWRDIAVVSRPFLQTVLLPLGSPASTPSRRRLKPTVDIGGGQLQLALNGFVACWRTEERVTDVHETSQFRLRLFAVVEDGSGTFIRSQFTNTTCHFFRNLPDQYKQFQLAIADVGTDTTPVPTLSSSTEGIKKAFDEDELVLNITLQQVHDVAATHGTPSASVLVFSDGISLYVLDKLDDFVMLTEPSKIAFALNNSQSITALGCVSETELLLGLSDGAMFRLDIGEWLHNFNAANNPSPAAAAAGGGGGGAQQQMNNSTTAFSEQIVHAERIRAPDGVAITQIVASVITERIYAVRDKLGIVRCQFHTCENSTTLTLTNSPNFIYRLAEDAWNGFLYYATNSGDVFSTPMLPLDATQNYSLSITRRLAELSPVSSLEVDLHEQKLIAVSRTGQLISRDLINGTVRDEREGWTLSDTYRNVVHAQFYRNRLFWTSSSCGDSHPWESCLYSEEFDHGSKAVHLSKYLYSGPVKEFVLLRPFIAPPFMVPPSKVGLLLTDSDALLSWRPPTSLPFQAIGSAWRSLAYEYILQFQPDHVENEKNDTVQTSTTVSQGTILTTHITVPVGLESVDGTYNLTIRACTRNICSSPVITSNRPFHADRMRKTITLYTKKSTLAEGGGIGGGQPSADPFLLLDMLGRDVPADRTHLYPKFPSVDATTVSIAYDNSSGVLYQSWQKDFTVTRSIEGTAAPLSAHFLDSVHFHMVALLVSRATILLASAYSVFAYRTTSSFNKIVYNCQPLVSASGEECGKVYGIATEEDHPQKGPGRVFLLVMLPSGVVQLLSSSSDLAQPFQLIATTNHFPYKIRQMAFADDRLLILTDDGFFGTIDLTLQTINLNFAVRDIQFLLAGDYVESIGDHRIHFEGPIQFDEKLGQFSWTISSWQNTLHKEVVAPSVVAIPAANGVQSLYKLSLFRDAFGGERIVLLSQASAYQLPQRLIQAWNSRQKFDLLLEAYNPWTAVALNRSALLTPTKPPSAPRNVRIFATQHRTVDGTRAIIDLFWDEPKEWNGDQLGYTVNCTIVATVPAGQQQGSSDVQSVNATLRRGTNRAYTFSVRSGKISCLIFAMNDQQLVGPPSSPPAEIDGSEFKPLIRLFAIDSTDNLVAIQNWTIESSVKNSVTNGNKARFLAKNRKRQIAHTVQYQAMTYVGSELYAIRKEPEMSQLALVKLDINQVDTVLSKASLLGEVTQIDAMAADWVANRLLLVGKRELTTIHLDQLQDSPSTVLLKKLFPLSLGAQDAKQLVYDPFTNTAYLLTKNGSLFALDLNRGIESNLELTTGCLRQKTITSIVGEFVWNKAASPQLYALTWNGLIELKLNSDNNCPDINVNWSLFGETGLKAISLFTVADKVLVFATPNDLLVYDRQTAAVSQFPSPSPPIRQLLAVSQSSQPFPNRDCFQLPPASQISFNVKNEGRTGAVVEVHELQLQKDAQQQQPNECVNVSQPITQYDVHFRKRGTDKHQQEKIKTVHSSSNRIVVDNGVLEKYTDYDVTVSWLNHYCPPQGQSEAKLLHTGFGYPLAPKEPKALALTPDTVLLSWTLPDLLSAPVAEIRYRVSQLSPALANPVPVAVRPAEGTAGHFSAALAEVVPCESNPCQAKVPNLRPSTDYHFWVVALHINRLNADDAEATSTESQAHTRDIPGTLRLENVTSDSMFLRWNTLMSGVDASSAQFVQISIQYRQSGVDASWTDVRNSTFALTDWPQRFLCVDQLHPATAYDYRYAAEYTIFAANVWAGAASTAATASAVDGKAAQQQLQLQQKDGGKKTVLIETFFQQSQQARTKAGTPSTPLDVKLANEQGCAYDATTKQSDWPTGKCEGGGWTLRWAEPNFDGGEPIQNYAVEYRASGQTEWEIAERGLPPDRLFWRVAWTETHARRGKTPSDEELAQGQFRVRAANVEGFGEFGYTPSSDKSAAGDGTTSISFWLYMLLALFTLLVLACCAACGYCKERFPIKMFEWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H979</accession>
    <name>A0A914H979_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914H979"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14427.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14427.t1"/>
        <property type="gene ID" value="Gr19_v10_g14427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14427.t1"/>
        </source>
    </evidence>
    <sequence length="439" mass="50390" checksum="DD46BA6D4DEC50C3" modified="2023-02-22" version="1">MCTIATHRGNFQYQRLPFGVKSAPGIFQSIMDSMLAGCTFAVAYLDDVIVVSRSPEEHTKHLEMVFARIANFGFRVKAEKCSFFQKQIKYLGFIVDKDGKRPDPAKVQAIAEMPVPTNLSTLRSFLGMINHYQQFVKNMRFIRQPLDNLLKQESVWEWSKECQEAFEKVIQILQSDRLLTHYDPLKEIIVSADASEHGIGAVISHRFEDGSLRAIAHASHSLSPAQKNYAQIEKEGLALVFAVQKFHKYLFGRHFILQTDHKPLLTIFSNKKGIKPCTANRLQRWAITLLGYDFEIEYQRTLEFGQADALSRLIAKTPTPEDEYIVATIVESADLETLNAVIKQFPVTSEELVKAVEQDQTFQNVMKFIRTQWPNTKEMSKDIVPFHRRRVALSIDNRCLMYADRVVIPAALQKEVLQQLHDGHPGIRRMKNLARQYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9C9</accession>
    <name>A0A914H9C9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione synthetase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9C9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15414.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15414.t2"/>
        <property type="gene ID" value="Gr19_v10_g15414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037666127" evidence="2">
        <location>
            <begin position="22"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15414.t2"/>
        </source>
    </evidence>
    <sequence length="592" mass="68441" checksum="3CD8C37C24B2F66A" modified="2023-02-22" version="1">MHYFISTISFIFLFYVPTATASVDKNDDTFLAFVKGDPNQNNEVLIQMYEARLGLMYLMRENWKCDKIRKEIKKEEKEYEECEKLRKYLDILYEYLFQVYTGPETAADQIVKPMFKHNDKNVSGKEVLISSQHDELNSSTNYTDILTTFLQRDDAKTQLLIKEAKDWAQNIELIIREPKFDANLSRWFYQTVVAPFTLFPSPFPRKFFEQAANVQTALNLLYFRIMRDYPFLKEVYQKLIKNEQPLSSALQIMEEIHLEGIKQPLTVLFQRADYMLCESNYEGNEKPSFELKQIEVNGSAIGGLGYSTRTSKLHRQILSKTGLNLSNSVENNTSALTVEAIYQACLKLDPHDFTLRYDDKIVAVVFNQDNMLSTDPKKMESRRTIERSTAIKAPSLAAALAHTKKVQQVLAKPGMVERFFPNPEEAPLIEAIRKTYANLWTIEEDDNNEYPQIIEEVKKDPHKFVLKKIEYAQYQNRNLARIYFEQEILKSMTNFTPIERSAYILMEKLQPTIVKNHIVKTMFDENMNVPPSIFEDVTPELGIFGTLLGNIVDGKVLHNVQLGHQMKTKLASENEGGIARGKSAYDSAYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9L8</accession>
    <name>A0A914H9L8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914H9L8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15073.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15073.t1"/>
        <property type="gene ID" value="Gr19_v10_g15073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="334"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15073.t1"/>
        </source>
    </evidence>
    <sequence length="594" mass="66669" checksum="E22805966D3EB6FD" modified="2023-02-22" version="1">MVVTLTTAEVASAQAKLDTLEIKQQLNVIQGEHGVLLLSNNDNHHENEQQQLQQSNGTVKMNGHHHPTTNGSANGTAPPPQGMALAAIVGARSYVSDLVPDVKQVHELAEYGLDYAHSIGLCGRTLEHKFKSDIATAPPLALFPSPFPHSLYTQAMEVQETLNELYFRISCDHEFLLEAYKDVIKGDPYIKRCVQIAQQIHEEGVHQPLAFSVQRADYLSHWDEQKQCIELKQVEVNIGQIGGPGSATQANKYHRKMLEKLAIVRAGKGIEVLANAELPKNMPRHKMGQSLYEGWKLFGDPNAVLLFVNQPDLFPFCHFEQVQFTTFQVEKLGIREGNRVEVIRMNLKECAERCRLDERDFSLYADGKRVALVHMAYGYLAEHYPTEAEWQVRIAMERSTAILSPNIRLQLTGTKKIQQVLSKPGVLEYFFPKEPERVVALRDVFTDLWGLENDDDVTNEVIRNAIQRPANYVLKAQMGAGKGNFFDDEMVQKLRTMSLEERGAYILQKKIWPVAVKNYMLRPFQAPYLENVVSELGIYGSIIADSSNGKVLWNSAEGYLSRSKPVSMNQGGVCEGSGVVDSVLLFPTNEFCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAH2</accession>
    <name>A0A914HAH2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914HAH2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15560.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15560.t1"/>
        <property type="gene ID" value="Gr19_v10_g15560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="15">
        <location>
            <begin position="428"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15560.t1"/>
        </source>
    </evidence>
    <sequence length="581" mass="66618" checksum="EE3C924645B9E749" modified="2023-02-22" version="1">MKSVSTTQPTHPSSFWLLFSSFLLYCLFNLPSTINVLNFEFADLFTSSADLQRLTHAEWEIPQLINNYIKLETERLEHLKSMAFKYRQTNEQLQTNIQSVSNPINAFRMIKRLTNAWKELQAEMRADVADAYLQNVTMEGQAKFPTDEDLSGAAVGLLRLQDTYRLDTRDLANGFVQDVKIGNEMTAFDCFEIGRIAYNNEDFYHTLLWMQEALSRAKRESTPTIAESDVLEYLAFAMFKQGNLKMALTTTDRLAEIAPTHPRANGNIKWYEDQLTADGVKSADFRKNIPPLDNRRRDDSLGDSERNIYEALCRDEVPVSVKETSKLYCYYKMDRPFLRVAPFKVEIVRFNPLAVLFRNVIVDEEIERIQELAKPKLARATVQNSQTGQLETASYRISKSAWLKASADEVVERINTRLNLMTNLEMETAEELQIANYGIGGHYDPHYDFARKEEKKAFSDLGTGNRIATALFYFTQPEKGGYTVFTELKTAQRPSKYDCLFWYNLLRSGEGDLRTRHAACPVLLGVKWVSNKWIHEKGQELLRPCALKPSVQERYVGDLGGPEPRDHPNISPYCKTGPQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAS2</accession>
    <name>A0A914HAS2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RIMS-binding protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIMBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAS2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15791.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15791.t1"/>
        <property type="gene ID" value="Gr19_v10_g15791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000016">
        <property type="entry name" value="RIMS-binding protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057884">
        <property type="entry name" value="FN3_RIM-BP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234:SF19">
        <property type="entry name" value="RIM-BINDING PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25523">
        <property type="entry name" value="Ig_RIMBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="277"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="373"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="465"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="751"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="868"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="913"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1151"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="927"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="968"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1199"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1210"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15791.t1"/>
        </source>
    </evidence>
    <sequence length="1225" mass="134000" checksum="94DAB48433E4AD20" modified="2023-02-22" version="1">MPAVVPSTALPDDLFDAPFGATLRRRAKSTVALAPTKRDNHSQHYRHHRRRRDGKTTTEEGEGGTTTQQNPLGADAASLRTMLRGKPNSRLFRALFQYLPLRDSPNDNPNVELALQAGDLVLVRGPMDEDRFYWGETLDGRSGLVPSNFVVPDDQLRAMLRLDDDSDDGKEHPQNNHGTSGDGRSRAGKMPLFNDCCPAIASTSAAVFGPPSTSPDRRHSLRLRPSSPSFTLKVPDHLAQISHDFTVSDYSSAATSDHQHLPDSVCPYPPDQPRVPFPRELQVEKRLSRSVLLSWLPPDCPSTSQSVPLSQYQVCVNGTIKAVVPGTFKCRALVEELELDRFVNVSVRAVGADGNASMDAACTLAVGAEAPVAPQHVRVSNVSPVSALLTWHPSNSNAEHVILLNALKVGVCPPAVFQVQLKGLTPSTIYRLSVRTKHPRAVLEKRPVERCMDFKTLPKIGLPDPPSNVQVEPGPQPNTLLVTWRPTTSQPRPPSRASVHSYLIFADGRNIAQVPSSTADHVLLRLADLADDPPVFLTVRTRTREGTVSADSNVVRVPRGDDKQQLRVQERRPADEHLLSCSLPSHILGDLISATAPSSMAPISADHVHHRCGGPCSSPSSLPFGLCQHLPPSTGTLLATANAVSANSVQTRDGQHGGLLLPIQLLTAAAGRRTRTVLHLPSEGTAQGVPAGRGAPEHVGDGAVLSAASPTTATTQKRGMPAQLTRLWDEFQTSGTQSEPDLRPSRIPGQEDSRWFVAIEDHQQAVEPDALGFRRHQLIKVHGDVDRNGFYWGEVRNRFGLVPAGKLIEIAKDDLFLAAEQRQQQQPWTSRSAEAPITRRMRWGSFKSRSYEYTTASGNRYPAALFTHSDEQQQQQQQQQQQQQQQQQQQQFLEGPPAFVRRSRGGAGGAEQYIRAGLGTRNSSYEPQERRTEREKDRRMSVTEMGESGGRNGGGGGIPERNPRRGDAQQQAMLMNEQQQEMTEEEETPFPQQKRGGMMAYEMQKDEADEREPEEVEVEEREQYQQQQQAIRDRDRPPLQPLRGMPSQLMVAKYDYSRQCSPNVDAEQVELSFRQGDLVTVYGPMDEDGFYLGELNGVRGLVPSNFLQPASQSEPSTSSATTRPKGVAFSTDLMMANHTAPPAHRKSVQQQMAGGGMPRQSVSRTVPTGMTSKMFKVTGTAPGPAGKTLSKKSSDLSSRKSSQSAMRGLTTGGGGVVGGGTKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAY8</accession>
    <name>A0A914HAY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14917.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14917.t1"/>
        <property type="gene ID" value="Gr19_v10_g14917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14917.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9595" checksum="5ECF0642594DF02D" modified="2023-02-22" version="1">MCPQGVVRTLLVNVPAHTQRACVRQQQREACGVAHTDSTGQQPLRLNRFQSTPRPKPTRIIVPEFLEMAQSRAATGGVFKGQGRIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB51</accession>
    <name>A0A914HB51_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytochrome c oxidase subunit 5A, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide Va</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HB51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15897.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15897.t1"/>
        <property type="gene ID" value="Gr19_v10_g15897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15897.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19929" checksum="535634945E921435" modified="2023-02-22" version="1">MYSLARKCAFNSATCKYVSKAFAHMSKQEIMWNWPAQKFDQHFLAYLNKPDIDGWELRKALTELANFDVVPDPKLVEAGLRACRRVNDLSLAVRFLEQIKYKSGGPVARAAVYPYIIQEVRPVLDELGIRTPEELGYDQPEFFTPEPESYWEKSWYKLYGYTKMPGFKHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB78</accession>
    <name>A0A914HB78_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HB78"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15750.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15750.t1"/>
        <property type="gene ID" value="Gr19_v10_g15750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="361"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="531"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15750.t1"/>
        </source>
    </evidence>
    <sequence length="681" mass="75848" checksum="A7C595067519BB1E" modified="2023-02-22" version="1">MVSPSSSDESSFLNFFAKLSPSSLCGWTPNNIWSSFWPVKIAKCDDWHMGISGGFMPRANSDQLLHIFNEYASIEKNGKRFMTAADFIRKYLGLYAEDNYNRETVRLLASAADTAKDGLISFEEFGAFEASLCAPDALYLTAFEIFDNNASESITADEFEKVIRHTTPLVELDFDFNSEFIKKYFGAKKQRSIGYHAFCQLLHDFYEEQGLQAFKKFDTQNDVKGHLLTEFTRNNLIAVAGGNSSAHKVRFPFYQAINSLLAKMELIKRVYQSIARGNIDLKVTREEFLQATQSYAQITPYEVEILFHLAELSHPGFRTVDQADLDKIDPERLKRVSHIIRLANVKAVKSKDERGVGTALLETAYRFLLGSLAGAAGAAAVYPIDLVKTRMQNQRTGSYLGEVMYKNSFDCFKKVIKFEGILGLYRGLLPQIVGVAPEKAIKLTMNDLMRDRLNFDGRISLSSEILAGGCAGASQVVFTNPLEIVKIRLQTAGEIINGPKACFLRDVPFSAIYFPVYAHMKMNTADEQGYNRPWSLFASAFIAGAPAAALVTPADVIKTRLQVAARTGQTTYNGVIDCTRKILLEEGPSAFWKGAAARVCRSSPQFAVTLLSYELLQRIFYVDFGGTRPTGSEVSTHATMLDQASENPHHIGGYKLAAATFSGIEHKFGLFMPRFETKLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB81</accession>
    <name>A0A914HB81_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB81"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15469.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15469.t1"/>
        <property type="gene ID" value="Gr19_v10_g15469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15469.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="38062" checksum="12538565515E9967" modified="2023-02-22" version="1">MSDNPKKVEKRLKEIDRFDRLVDAHFKSMECTLGVLDIRRATNGDHAEIVKRFDRVYKVARRLPIPQEPLPDNVIEFESIWIRYIDRSVIEFLRRIQRLFDSKETYLSIGTPGNENRSWEIIWEKIWPLINDNICAILLRGNSLGCLRRFSLTVLHDCPKLRLIHARYAFPEFPVDDSASASSEQALTKWLHTPRGDGLPKMLQCEFYSTGMERLQNVAFVNSTNPVNFIIICLWELDFSVDIAPFDLKNDLTGERLVWLSDEDEWRLVRCPIERDEDKWAKWEQEASDCNWPFYWNRIGINFKDSEIGDGRRKRRHLMSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC46</accession>
    <name>A0A914HC46_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC46"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15239.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15239.t1"/>
        <property type="gene ID" value="Gr19_v10_g15239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15239.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12448" checksum="608370EEF78927D3" modified="2023-02-22" version="1">MKAELNRAGFKNSYHHEIDETVAKELGLNFRTIYRWKKELGQTKPNKHSQSEQKELMKRYYEIKNQNPKNSDKEIAKMLKIGSATLDRWKRQFKRKQCRRAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD18</accession>
    <name>A0A914HD18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16235.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16235.t1"/>
        <property type="gene ID" value="Gr19_v10_g16235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16235.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33494" checksum="31224DF5D1455690" modified="2023-02-22" version="1">MALTGTSDTNATKTTICANDKSAAAEAATNNGTNLCNNNSTRVGAFRHKIVCRVCCWSPPTTVLMFLAFCCVLLSSFGAISNAELIPSNVFNTENANTDNNAHQQPQPQHQSKHAALKRATKMHQKQRQQQTEEAQQQFTDEQRMPPLVLLKLLDDVEAESGNNNNNFLPLIDYKLAMDNSRSSSSTEENILSSSSSTDDRTEQFQDQSVVMLPLLPPKRKKSVRRCGTLLLKHIQTVCGGCLRSPNPSETDEAIIMGKRDGESQLDMRRRMKKQSLGFSKITDICCTQRACDDEEVKPFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEB6</accession>
    <name>A0A914HEB6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Integrin alpha-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEB6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15832.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15832.t1"/>
        <property type="gene ID" value="Gr19_v10_g15832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038165874" evidence="13">
        <location>
            <begin position="25"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="334"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="407"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="477"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="14">
        <location>
            <begin position="525"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="686"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="16">
        <location>
            <begin position="840"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15832.t1"/>
        </source>
    </evidence>
    <sequence length="1154" mass="127519" checksum="576EEC50AD57F128" modified="2023-02-22" version="1">MRSTEFLRCASRLLLLLSVDVLTAFNMDVDNPVFRRGPPNSSFGFSIAQHFQNGKPILLVGAPRADSGQPNTVQAGAVFACAMAEDFSTNGRNQKRTPAATAVGRCTQLMIEYPAGEEFQRPPERLNSKSLHSEGKNHQLLGFVIRSSGRREEAESRAMACAPLLRWSPNAFTDGVCYLLNSELNHTGVLSPCETLPRTDRHNDYGACEQGFSGFIDDHVILTGLPGARKWTGGVFGRYEFDSGGFPDTVDRWTMEVGKDQRGVINILTSHDYLGYSVRYGRFGFWYEQADVDGVANFTVVSGATRYNQTGAVVFLPFWRHVQAEGQRQLGLSEDFFLLAGRQLGSGFGSVVEVLDLDADGFDDILVGAPFEFQPNSDGTALAGGAVYVFYSAGVRRQKGASAQVFRAPLILRGSGAHSQFGAALTRLGNVDNDPEGLQDFAVGAPQSDSGQGSVFIYFGAKWPDFSTDPAQEIHANVLNGRRSLGQNLSAFGGALAGGVDMDGDGYVELGVGAYGSDTVALFRARPIIDVQLAHFFPQKHIKIDADSTCSPTAHSCFTMVTTLRILPRNDSSRLLSRHFPGREKPFLCQLQVIPHAKGVLPRAVFVSSGANSMEWRCGRETIVGAEERQEHSLYVPKGNPDWTNPLHFNLTVSVARRDALEVLPRPVVNRDQRSHYFEIAFDKKCGEDNECHAELALEATLLDITRRKDGIYIAKVTERDSLVVRFLVENRLERAYLAKLFVEYNNDELDEPRLMQRDYQGVLDIERKGEGLVVVGLGNPVEAGRKLSFDLAFKLVRGSSERVSASLNFRALLNSSSVEKDPTNNEWSAEVQLIKEADLQLEGASRPAIVRFSKGNRLVVDEVDIGPQVVHVYTITNRGPFYARNVSLTVSWPLQLSPAGPPPSSTRQLAPGGWALYALEAPLVRHNGQFRRCASPTHAPKTINPMGVYNDETLKLDYQLAKRQRPKRAMGRTDRTETAAEAAPAISIFDSGRIRRKEVEESSGAKVRIADINCKDGSALCVPLHCHFDYIGRNDSVLIEIRARLWNFTFSADYRAIDYVAISSEGFIEVDPSQGILEDVTNNFARVTTHAYPDRPQQEGQVRVWMLLLAVLIGLALLGLLVLCCSRLGFFKRKRPESLLHQAHYQHNREYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEL0</accession>
    <name>A0A914HEL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16639.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16639.t1"/>
        <property type="gene ID" value="Gr19_v10_g16639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000008">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16639.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27555" checksum="14C6C5000F32CB3D" modified="2023-02-22" version="1">MILSSSNSVFSNRFARGTDDNDSTNQDDHSLAKFSLPNDSQLSSEETDLGAQQHAQNALDSSRLIDASPVETLIQQLVENGTEFLHLLSHSAASSSAESLASPTNTTTGSSSSNDAMILVDEKAAELFPFDTILPMIVVALSVSFIVIGGAIPYVFQYAEIYRRKSAAGFSLLVCLALCIANILRIEFWIGKRFELPLLVQSIVMLAVMAAMLEISVRMNRRIVPLTARTSVWSESIFKKSFFFCHFALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFF4</accession>
    <name>A0A914HFF4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 86</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17027.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17027.t1"/>
        <property type="gene ID" value="Gr19_v10_g17027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17027.t1"/>
        </source>
    </evidence>
    <sequence length="634" mass="70792" checksum="A85FCEFA6074FF99" modified="2023-02-22" version="1">MMLFYPVRVIVLEAMPKPKTPVLVSQVVRKFDSSRKACPYRFVLEPKKLLIETSDQWRPEQIGLVCRHRKREYRSKMRSLEDSCFVGNRRVVVWPEGVMDDPIEFVTTLYKNKQNDILESKEWTMTVEGPMVRTNAAATNSKSADRRRRLVRPLAAGEMDMPKVVGPKDCVAEVRLKLRPLHDGVLCCFLDLVVHCFPSANSDCIYSPVSRCLGAPINNGTSVNDGTSTNDGTSINDGTSINDGTSINDGTSINDGTSINDGTSINDGTLINDGTPTITGTPTINSTPIIKGTPIINGTPIINGTPINHDTPINHDAAINHDTPINHDTAINHDTPINHDTAINHYTPVNHYTPIIDSLPIIDSMPINNDTPIINGTLINDDTHYLRSTDEKEQLSRRQDLFNAMNLNETVKIAQLRTKITDGVDDNDGSPFYASLRHDSNAMLLELKEMMNQNCASAPPVASSFTSRALRVSASVGRVQHKQQQRPPPTSPLMYDTKAYSERARELAERLTQCVRSIKDVEQQDVFVGERMLAMVPGSEAETELINHHLRLIDEKEQLSRRQDLFNAQLDLNETELKIAQLRAKIADGGDDNDGSPFYASLRHNSNAMLLELKEMMDHKNDLMMRIADYEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFX5</accession>
    <name>A0A914HFX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hint domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16591.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16591.t1"/>
        <property type="gene ID" value="Gr19_v10_g16591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hint" evidence="3">
        <location>
            <begin position="228"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16591.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41195" checksum="C79FBA6B810469EB" modified="2023-02-22" version="1">MDTKKRPETECKIPEEAERMTNPKKPEETKTQTILVPEKMETKQRPETPEQMEMECKIPEEAERMTNSKKPEETITQTILVLETKKRPESPGRMKMECKILEEAGRLIESKTDTFLVPETKTQTMLVPKTKKRPEKPEEEKKPQMDMIQQKLRMLFNAIGGASSNGSNNTVKEGIASGSGQNAEQMPISASSSNFDPNSSRGSSNAKRHNDAEAVSASQNQDDPPVPANCFSADTLVRTVYGEKRMDQLEVGDLVLVPASAGTLKYERVELFYHIEPDTQARFLQIVTESGKTLSLTALHMLPFGNCSEMRETNLDIEGIEQWMRKSRFVHKASVGDCVFTLDDRQNEPTVRVERIQKVGLDWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHI0</accession>
    <name>A0A914HHI0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HHI0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17211.t3">
        <property type="protein sequence ID" value="Gr19_v10_g17211.t3"/>
        <property type="gene ID" value="Gr19_v10_g17211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="21"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="328"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="436"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="882"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="889"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17211.t3"/>
        </source>
    </evidence>
    <sequence length="916" mass="104854" checksum="0B11A23E27EB47D0" modified="2023-02-22" version="1">MAKQTRDEGKFVELEGAEMGKVVVRFPPEASGYLHIGHAKAALLNQFYQQSFSGQLILRFDDTNPAKENAHFEEVIEEDIRRLQVEWDRMSRTSDHFDALLDFCEQLLSTGKAYVDDTEAEQMRKEREERVESRNRGNAVEQNMALWGQMLKGSERGQQCCVRVKIDMRHNNGALRDPTIYRCKSESHVRHGDKYKVYPTYDFACPIVDSLEGVTHALRTTEYMDRDEQYYFICDALGLRKPRIWAFARLNMTHTVMSKRKLTWLVEQGIVSGWDDPRMPTVRGIIRRGLTVEGLKQFILAQGGSRSVVTMEWDKVWAFNRKVIDPVASRYTALDGTSATLVPVKIRQFVEEEYRRVPLHPKKPDGDSKEVWFSPDLLVERTDADCFKVGDTVTFVNWGNMKVAEVRRDEGEDGGRMASVEVDLDLDNKDYKKTMKVTWLANHAENFAINTVRYDHLISKSIIGKEEDWKELVNRDSVHVGTLLAEAALKSVKCGDIFQIQRKTFFICDENTSTSMTLIEIPDGKESKKETEANPSLIKTKTPKTGPIDLTIDESDFPTFRANLPSTFFRCSVDESSASFDFPTFRANLPSTFFRCSVDESSASFENNDFPTFRANLPSFFSRCSVDESPRSLRNSDFPTFRANLPSSFFRRSVDESSASFDFPTFRANLPSTFFRCSVDESSASFENNDFPTFRANLPSSFSRCSVDESPRSLRNSDFPTFRANLPSSFFRRSVDESSASLENNNFPTFRATSVDESSQSLRNTDFPTFRGPSSLFQTSVDESPKSPACKHFRHTVLVEKSPKLAYKPKLIRPNPASPSVVQLGLRRSQRTRLPRLLSHMGQKAQYKHDKDGNQVLVGVSEVVVNDRLLKKHRMLDIVTASRKEQESKHRKQIAKRKRRCQRTMHHISEVDEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHL0</accession>
    <name>A0A914HHL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17234.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17234.t1"/>
        <property type="gene ID" value="Gr19_v10_g17234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000016">
        <property type="entry name" value="Polyubiquitin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17234.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15479" checksum="E1B01DB70689D5F0" modified="2023-02-22" version="1">MQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGKVHGSLARAGKVRAQTPKVEKQEKKKKKRGRAFRRIQYKRRYVNVTMAGPGRRRGPNSNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIC8</accession>
    <name>A0A914HIC8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIC8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17801.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17801.t1"/>
        <property type="gene ID" value="Gr19_v10_g17801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF18">
        <property type="entry name" value="LD43650P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17801.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39516" checksum="122A21E279F5D17B" modified="2023-02-22" version="1">MAQKDDDPPPNAADILNNNEHQIPAPVVKALLRMAAHPITFANTLIRLGHEPYPLSRGKKWILFGELVYFQPNIFEYLSNLCQSHGFMTICTGFGANLMAFFAYDILRDFTDRFMDQHYPEIGGRMEDNMLQMETANNLDNYQLFRVKFRQTIRDTISHFVGTVVARPFIVIMVRQIAQHITNEYKYQTFNILQPLLHIGELEGPAGFFSGLVPQLIGEFAFIWGAALVGYGFKLGIKYFKLDQVASSDQQPKSMFFSGLQWFCRSTLCQYLSYPFYVVSTLIAITGSGLAISMLPFSPLFTHWADAYAYLLPYELRRGQLAFLRHELGPVSLGADGKLYASKKHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIM3</accession>
    <name>A0A914HIM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phospholipase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17248.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17248.t1"/>
        <property type="gene ID" value="Gr19_v10_g17248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
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        <property type="term" value="P:phospholipid metabolic process"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hemopexin-like domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="110"/>
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            <begin position="197"/>
            <end position="229"/>
        </location>
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            <begin position="214"/>
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        </location>
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    </feature>
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    </feature>
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        <location>
            <position position="21"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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        <location>
            <position position="23"/>
        </location>
        <ligand>
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        <location>
            <position position="40"/>
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        <ligand>
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            <begin position="20"/>
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            <begin position="42"/>
            <end position="88"/>
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    </feature>
    <feature type="disulfide bond" evidence="6">
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            <begin position="52"/>
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        </location>
    </feature>
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            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004613"/>
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            <dbReference type="SMART" id="SM00085"/>
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            <dbReference type="Proteomes" id="UP000887572"/>
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        <source>
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    <sequence length="459" mass="53064" checksum="740F7F43BB94D544" modified="2023-02-22" version="1">MTECKLHYTALVYDDYGCWCGIGGSGTPIDGIDLCCKLHDKCYDSAVDQGLCYDTYIEYAEPYSWSCQGTELTCPGQQIGCKAALCECDKHVVDSDAMPFSWLYLVQLVRHRFFLLLFVPLLITGSSTPSSPSSSSLSEFDSSVSEFAFTDSHRGVLFHDGEHPFVPRRIPKLSRSAKRKLLLEQFKREGTEPPREFFETDWANGRKRKDSDKRHKRRRATSQTQHRPRRVQYRVRPQNKPRINGQLQARNVGQCPSKLDAVTEAFNRHLYLFAGEMVYEVWRDFQGLQQRRAFALPEVFPDGPRRVNAAFTNRKSGVTILLDYRTVYRFRWDKSYKRFYMARRSPRQLPSQIDFLPRMGFQWKDGHLILSNNKKFVSFDPFWNLALFSSDKANEYFPNVDKRVVGVAKHGKDAFLMITEDGKLQVYDMHDHKVNLEFPISLRHLLACLSASNSTLTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ24</accession>
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        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
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        </location>
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            <begin position="52"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17626.t2"/>
        </source>
    </evidence>
    <sequence length="217" mass="22450" checksum="D34627C34AE3C8DD" modified="2023-02-22" version="1">MIYYSLFEFPFLIISFVALMTEAQDFPPVQPVPAPPAAEPQNMVENATATATTATGFPPTPTGSTPGGPLNRMGNFLSGLVGGEQQQQETTTPGANASDHEALSNNDRVANASSTASANIGDAGGIATTVTPPLDNTTSNVFSSTTEMSPSIVEGPEVEVWNFAEGMDNMTTTTSSTSSTTTERPPVPASAAVALNAWAVNLVASAAFAGVVFFHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJR3</accession>
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        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <lineage>
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    </dbReference>
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            <begin position="1"/>
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            <begin position="17"/>
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            <begin position="6"/>
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            <begin position="35"/>
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            <begin position="35"/>
            <end position="48"/>
        </location>
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            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
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            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17828.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12545" checksum="14F5B4182358A489" modified="2023-02-22" version="1">MQFLSISILIISIAFAACFVCGAFGGCFVSKQTAEPMQKTTRRSNGISMESGIGINGQKPNRKTQNFRKLKSKQELPNESNDREIRDLSQGPNMRDVINTAKFVKARKSSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL38</accession>
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        <recommendedName>
            <fullName evidence="4">Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Tylenchomorpha</taxon>
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            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-1-beta/EF-1-delta family.</text>
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        <property type="protein sequence ID" value="Gr19_v10_g1794.t1"/>
        <property type="gene ID" value="Gr19_v10_g1794"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="4">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1794.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9000" checksum="1129BE678AB32A6A" modified="2023-02-22" version="1">MGGRGPWDDTIDIKDIEEKVRFIKGDGLVWGASKILPVAFGVQKLQVDVQTGRCVVGWTRTLRRCAEKLPMCAEWRHSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLF8</accession>
    <name>A0A914HLF8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PB1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLF8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17713.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17713.t1"/>
        <property type="gene ID" value="Gr19_v10_g17713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17713.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31971" checksum="E7423C152F79F0D4" modified="2023-02-22" version="1">METPAGIDEVYKPHECRIHEAVFDTLSKPIHSTNDKRTHRSRSSPSPLKGRNQQQNGHRLHITWNHFGQKAKFHLDPNCRDLFEALHRSVHEELPNFRGNLAFKDYDKREVLIRCDRQIREAAASSRGGNRLHIYTTLSDTPSHHLAASELGTLSGSRPSSRVPPLRRPTTADSSTPLLRAPEGRGRRRVDEENFLQRAREAVGGRSDDEERRHQSGTVEPERTQTLSLAYPFWPAGAFPIFFRGCWIGPNKFVYGGGWGGWGPIPSRKNWHSVVGGGRPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLV0</accession>
    <name>A0A914HLV0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1978.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1978.t1"/>
        <property type="gene ID" value="Gr19_v10_g1978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1978.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22703" checksum="EB9D0AA3D9F2982C" modified="2023-02-22" version="1">MRPPKIPDRPLVPIVPKMMGISRVFNESCETLMPLDTEQEGDGLTIHFQGENGTGSSSRNGCTWTTNMAPSVTNDSMQQQQQTKRKRKVPLKHQDYFMLFKAVKVEYTMPDGKSHLDVLTKRMSARAFCDEATDFFAVAEVTGHESGLLGTSSSAAAFLTILSLARGQCLKSDTVVTRVLNVLRMKFSVSDISKSRSVKRLALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMC4</accession>
    <name>A0A914HMC4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M41 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMC4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2473.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2473.t2"/>
        <property type="gene ID" value="Gr19_v10_g2473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M41" evidence="2">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M41" evidence="2">
        <location>
            <begin position="222"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2473.t2"/>
        </source>
    </evidence>
    <sequence length="381" mass="44808" checksum="CB91032FE8C9DE05" modified="2023-02-22" version="1">MFLYFRNALQANIIVKLEEDQKQTDVVGMEQQHHQHLHQQLVVALSERVEQLELERKETNRKFEQQLEELENSLKDAINKQWMERKELTQRTRIVRKDTRKTAWGRPSRAPMDEFFELERGGVEYFRMCVHEIGHTLCHWFVADAERFTDCTIIPNEQFDGATFSEEKERYSLKELKARMAVLFGGKIAELEFFSTAVGIDSDRHDLIEDVEKVFTSFYKMCVHEIGHTLCHWFVADAERFTDCTIIPNEQFDGATFSEEKERYSLKELKARMAVLFGGKIAELEFFSTAVRIDSDRHDLIEDVEKIVERNTKLRTRLQRRKARERLLEEAEKRLTTFDGLLGRTQTMPVGQTEPVVGDAADDQTQWMKMSFLKLNVVYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNS0</accession>
    <name>A0A914HNS0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">legumain</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HNS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2841.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2841.t2"/>
        <property type="gene ID" value="Gr19_v10_g2841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037516745" description="legumain" evidence="10">
        <location>
            <begin position="23"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Legumain prodomain" evidence="11">
        <location>
            <begin position="338"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="800"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="923"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2841.t2"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117859" checksum="399A62B08D612618" modified="2023-02-22" version="1">MTSIVTFLAIFLFFNSLKVAEAADKTDGTIWAVLVAGSNGWWNYRHQADICHAWHVLVDHGVPPGQIITMMYDDIAHNKLNPYPGKLFNSPLMRDVYEGVRIDYRGDEVTPANLKAVLLGNEGAVDGKRVLKSTDKDKVFVYFSDHGAFGLIAFPYVRHQENILTVKDLTQTLQRMHAKRMYDELTFYLEACESGSMFDQKTAQQINVFAATASNAFESSWGCYCDTNITGLEYTCLGDLFSVNWMEDSDKRLFLRDETIGEQFNLVKRLTEFSHVKWFGNVRMMTANLSEFQGHLGSNRRVGAADAEKRLSPRNFKMFPSREIPFWTANSEKRKFELLEKRAFVDAQMERIERVLGRMLPQNASNGRPSPADQQGITQLECHHQVMHTFNKFCFNFSKSPYVLKYAKRLANLCEQRLLDTAQIISDGSGGGGGGTESGRKSDALRIRKSPSEEAEGMSAESGGGRCAKAKPKKRNRRREQPKGQQLCPPLSLEAMKNKYIVIRDEHSKLFGHRFLNSQLSLYLGSVQLLFCLWALTQHIWSMASLNKILYCDFSPNSTLPPLFTHVDAIIFDIGLFHNLWGISGCVAQHLDGGYGRFCWCIAHSAALLFCLPLAFVSRPKPNWLWPLLIQQSAYGVGMLILSLAALPRAAHFLGDLSNAPVKAIVFYSLGTLMNFFLLYVYWHWYWHVETLWNSARKLRRGETFTGSTTKRPIRRCSPVGGGRAPLLEVTTAGGVPIRNGAIGEGTGRMPKPTGRLPNECAVKGGGTEEHKGKIGSAEAAGHLLIVGVENARNARAVQTGAGGGHLDNNHAKVARSPDDVLGGERLQKRRRKSPSLLEGMDSGNSPNSFHSLGSTTASSIASTTTSSTTTQQKPIRKPPPPAPSPAVDASDQEKCRSHFPNHHRTTCLNELTLSPRKHLPQLHHQNHSQKRSSGRLSFSSSVKEGQILSPKRRNSRRRSIRQRNLLLGPRWRAERGIDQRSLGFGVGNGLIDLRKTETLNWRSKLWTGTTESGTGHRREGQFGPNSIEWVDAIDASVQPEKNIGKQHNNMLEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP57</accession>
    <name>A0A914HP57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP57"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2607.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2607.t1"/>
        <property type="gene ID" value="Gr19_v10_g2607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2607.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11296" checksum="DE51BE76E65906C3" modified="2023-02-22" version="1">MYFVNKQQKAATVNAFVCKGPNALLHKSPSHARHSFTFADFPLAHLAWEQFLPQYLITICCFAFDVKTARNMRATIHLHKVLLSHLPLPKRSAVETFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPK0</accession>
    <name>A0A914HPK0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPK0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3040.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3040.t1"/>
        <property type="gene ID" value="Gr19_v10_g3040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3040.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7619" checksum="7160BCFB38BAEB3D" modified="2023-02-22" version="1">MADKWTADHSLKFDGIYLSSNGQLMFVINDGTQKRVLSYEEAMDTDMRGVCNFLSAKMKQKLAVQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ36</accession>
    <name>A0A914HQ36_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GATA zinc finger domain-containing protein 14-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2660.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2660.t1"/>
        <property type="gene ID" value="Gr19_v10_g2660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2660.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18143" checksum="E62108AEABB1349D" modified="2023-02-22" version="1">MKGLATKAFQLVDELRNLHATKRNNLSDSLDSAPTNPYSPTGQTYNNSNPSYPYNNNNYYNGYNPNNNNNGYNPYSNGYNPNPKNNKDYNPYSSGYTQNPNDNNGYNPYSNGYNPNNNKDYNPYSNGYNPNNNNGYNPYISSSSDGGPNVSADVLQHTVRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRY3</accession>
    <name>A0A914HRY3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g34.t2">
        <property type="protein sequence ID" value="Gr19_v10_g34.t2"/>
        <property type="gene ID" value="Gr19_v10_g34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037226121" evidence="1">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g34.t2"/>
        </source>
    </evidence>
    <sequence length="104" mass="11481" checksum="2C15A56D87D16D89" modified="2023-02-22" version="1">MPKLVIGILFGYNLHLILGCEEQVEFSEPGQKEILIKASECAAKRWKLLTVAKDESGTLTVVDEAYTKLDGIGELTIHIGDELQPRLQQRLGIVCSEATLNLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRY7</accession>
    <name>A0A914HRY7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRY7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3403.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3403.t1"/>
        <property type="gene ID" value="Gr19_v10_g3403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038000049" evidence="2">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3403.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33714" checksum="9DFEECE2E81A33F8" modified="2023-02-22" version="1">MENFWILFLVLFFTTNSLDKAESVKLELKTFDEIFGEGWWDKGEAEDLKTPTPTNFGQNVHHQIDRQNTQIGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQNPPFTESDHVDNAKNGEENTAEEEQKRKIIAKFHAMKDEFKQKGKFPYKERIQIEDKIAKHLKRKAELKRAGIKNSQNELDKTVAKELGLSVATIYKWKSELGQSKPQHNHNEQKELMKCYYQIKDKNPKIRDEDIAKILKIGRVTLCRWKKLFKRQQFHPNSVDGHSVEVNATANVQEIGKSNLAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTC3</accession>
    <name>A0A914HTC3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTC3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4273.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4273.t1"/>
        <property type="gene ID" value="Gr19_v10_g4273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4273.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10467" checksum="36D35EEAAF65DB97" modified="2023-02-22" version="1">MGWATKKEDPSAAGYEKPEGRMDCANAVGGEGGANGQQRAWGDEWEKGRGPRGGGKCGNGAVGGPAERQRLAPAGHGERKSERRKGWRKSTGGLAARSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTK2</accession>
    <name>A0A914HTK2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTK2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3844.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3844.t1"/>
        <property type="gene ID" value="Gr19_v10_g3844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3844.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18017" checksum="EC4B084015C6EF79" modified="2023-02-22" version="1">MGFPRTECGVNLATRQIIYTKDGKRLETTGLFVASAADLFPCVSPSDPGDKIVANFGPDFEYNNPTLGRTLNTTTYVLTLVTDQHGNYVISHMIEHGRPTTGGNYMIRHVIEHRVPRTEFGVNLATRQIIYTKDGKRLETTGLFVASAADLFPCISPSDPGDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU10</accession>
    <name>A0A914HU10_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914HU10"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3758.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3758.t1"/>
        <property type="gene ID" value="Gr19_v10_g3758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="285"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3758.t1"/>
        </source>
    </evidence>
    <sequence length="547" mass="60946" checksum="D0A87BA0817F2C51" modified="2023-02-22" version="1">MIGNIHLAESNGAARVKDGTELVKPLNTVAAQTDACNNVKQYVLEAIRDEQELYNMEQYAIDYAHSIGLVAPMPDQPMGTFSNIVAVPPPITLLPSPFPLELYEQAVDVQQQLSELYFRIASDHQFLMDSFKDVIKTDPFMARLVQIAKLVHDEGVHQPLAMQLQRSDYMVQLEPLDGTLALKQVEVNIGPLGGPGFATGISKLHRKMLDKVAIVREGRLAMLANAFAPVDRSRQGLAYALYESWKLFGDPKAILLFLGTPGILHFEQLQFFQFEVEKLGKKDGHLVKVLSLTFVEASKRMSLDETGDFSLYIDGTKRVALVQITDGNVPDEFPTEREWTARTMMERSTAILSPNIRFQLSCTKKIQQLLAKPGMLERFIPNNNSKLMDQLRSTFTGLWGLEEDDQATEEVIEAAIRSPGNYVLKAQLESGLGNFFDEEVAEMLQKLSKQDRAAYILQQRINPLVVKNFMMRQMKPAQMEDVVSEMGIYASLIGNQFTGQILHNSVAGYTIRSKPSKLNQGGVDSGGGTVDSALLFPTAEMLEAKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU82</accession>
    <name>A0A914HU82_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Receptor ligand binding region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HU82"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g424.t1">
        <property type="protein sequence ID" value="Gr19_v10_g424.t1"/>
        <property type="gene ID" value="Gr19_v10_g424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037687103" evidence="5">
        <location>
            <begin position="24"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="167"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g424.t1"/>
        </source>
    </evidence>
    <sequence length="333" mass="36671" checksum="F664440A2CCAD736" modified="2023-02-22" version="1">MGPQVPFILLLIGFLLAIRPAIGAELSSPIYGTFHREDGHSLSERRQILLVESLFFGQPLSTYRNRTRRQTAAQIAPQTPRIGDNISADRTSSTIAPTKKASAKNFVKKELQGKVVVKIGHIGAQGAMPNGDRVLEISRMALLDEGILGEELDFDLSSSYSILSIVACGDSYEGVASAAAMYHKEKVRVFLGPYCASEFEAVAKMCSFWNIPAISYMPTTTAVSDRNIYKTLARISSKNTNLIAKALVRLVEHYNWKKLAIVTNTGPIAYERVIAFEEEFRRTNAVTVVKKFVLDENWDSNEIIRSGLLADLSANARGKSPEGNKSIRSLGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVG0</accession>
    <name>A0A914HVG0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVG0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4861.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4861.t1"/>
        <property type="gene ID" value="Gr19_v10_g4861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036825981" evidence="5">
        <location>
            <begin position="24"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4861.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20959" checksum="E1F23AB7F61CA6B0" modified="2023-02-22" version="1">MSGHLSISVTFCFLGCAMFAVFGYDDDLFEVGTPQSVAVKGVLTCNGKPIVGTKLKLYDVDTFDPDDLMAEGFTDEKGHFLLKGYETEISDIDPKLNIYHDCNDEHIPCLLKFSIEIPDNYITEGKQPEKIFDVGKLNLEGKFSGQIFTAPSAINSIFALRDPFFTFAIPINSNSLPIENNRRKETNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVH9</accession>
    <name>A0A914HVH9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HVH9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4162.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4162.t1"/>
        <property type="gene ID" value="Gr19_v10_g4162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000044">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="12">
        <location>
            <begin position="235"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="263"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4162.t1"/>
        </source>
    </evidence>
    <sequence length="688" mass="77079" checksum="DF15DFF8E9760421" modified="2023-02-22" version="1">MENMETENIMNSGGTMKIALKVAADKALAEQIDREKEITKERVAILDFGAQYGKLIDRRVRECNVCSDLLPFSTTMDELVRDGYSAIILSGGPNSVYVENAPVYDPELLSGRLPLLGICYGFQLINKHFGGSVSLQPRREDGRTRVKVNPQSDIFHELQPDQFVLLTHGDGVTPETAAKNGFRSVALSGEFVAAIENPERRIYGLQFHPEADLTEHGIQIIDNFLRRICSLKCHYTLQNREQMCEERIRSAVGPTGEVLVLVSGGVDSTVCAALCTKALGGERVHAIHIDNGFMRLNESDRVMLSLQDIGLKVHRFNCVSKFLTGSIVQNGVQTLPLLRVVSPEEKRKIIGDTFMRCKDMAIQKLGLSADNIFLVQGTLRPDLIESASELASGCADVIKTHHNDSALVRELRDLGRVVEPLQEFHKDEVRELGRSLGLPEHIVNRHPFPGPGLAIRILCADEPFKEEHFEETQQRIKEIVEAFDDRFSAILLPIKSVGVQGDRRSYSYVAAVSIKNASTENIPWPKLEELARLLPNECHYINRVVVGFDIGPVNDITITHINEGTLQQLQQADHIVYQTLCGLDWRDQPNLGLDNTLQCVQQFPVIMIPVHFLRHFKPPQHFPSTLRSIVLRPFITRDFMTGQAALPGRDIPFETIYEMVRRIEAEMSSISSVLVDLTSKPPGTTEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVJ9</accession>
    <name>A0A914HVJ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVJ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4179.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4179.t1"/>
        <property type="gene ID" value="Gr19_v10_g4179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4179.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13726" checksum="D7800AC2C4FC4604" modified="2023-02-22" version="1">MRSLFFSYFGLRRRVRYWRRNKFIRPIKTYEGAMKVKVFVSGLFFFLGWSYFGRIYFSRSATVDEDGRKRVQSIASRVKNREHVNILELMTGKESKPRRPPVELAKTEFPADDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVN6</accession>
    <name>A0A914HVN6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVN6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4597.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4597.t1"/>
        <property type="gene ID" value="Gr19_v10_g4597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4597.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9081" checksum="32563E937C6CA907" modified="2023-02-22" version="1">MCRKNLLHLYKRCVQWMEVRVYMCAPTPFPARPPCPTSNWGRTPECCCVCGAPDPLPSLEMAHLSADRPSTDGGGCIRLESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWI1</accession>
    <name>A0A914HWI1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWI1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4415.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4415.t1"/>
        <property type="gene ID" value="Gr19_v10_g4415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4415.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34188" checksum="EB443AD8CB360B27" modified="2023-02-22" version="1">MDQKRKAAHFWSTLRLCGERRKVQAELAMGSRENVASAKVRIEIRVAQKYSGKGDEERNRIRDVACGNTMATKKALYRASTKRFTNVCTLRGLTNGDCRYLWVTLRGRSALPGSAYFDEMLMRHIDEELAIFSSPRHGHSCRSIVHGTDAGEESAVAIDEGRQQPNQPLALTAEIDANIEREKSDILAFLNTDFEDEQFAVNMSHFFGRVGHLVGFNAPPRAELDEQMQEAAAMEEAEASLDESGNELGKRERVGGGERVGVERVGGERLSYRRIDNHFVIGQHDKRVRAMVLIGCGTETSAASTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWL8</accession>
    <name>A0A914HWL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4449.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4449.t1"/>
        <property type="gene ID" value="Gr19_v10_g4449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4449.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16135" checksum="12736CFEC76C8E2E" modified="2023-02-22" version="1">MCFGMGVKSLLLTTFQPVNVLDARWLYQFLAHDVGIEGAAAQSDNIKRRTTTTTWTACGRLENVCVDCVFEEKIFLYDEGLEYRPSERRLSQNLSAYRPSERRLSQNLSAYHPSEFRSSQNLAEFRPSQNFRGVLDEDASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXU4</accession>
    <name>A0A914HXU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5027.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5027.t1"/>
        <property type="gene ID" value="Gr19_v10_g5027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF137">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036745502" evidence="3">
        <location>
            <begin position="26"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="4">
        <location>
            <begin position="79"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="5">
        <location>
            <begin position="358"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5027.t1"/>
        </source>
    </evidence>
    <sequence length="591" mass="65174" checksum="7F849287BCF81982" modified="2023-02-22" version="1">MPNPSRALRLSLAVLALTSLSPVPCQPPLPAAPAAIDPLSRNNLSSPPPTAASSSSVPNDVSPLLFQNTNAGNAGIFVRLMPTGLAYLREIGMKVVNDEILKISLPTITEAIDAGQYWPPVDYTLDLITPDTFTWRMSKMHLRSNGNFDARLNGALLLPTVPIQGEFEALLGHLGLTISVRMLRSASGAPQVQRIFCRAAVGYVDLSVRNSGVITDFFINTFKAFLIAHFKPTVEQRICQMIEGVINGDMNAVLATMPLKVHINEDNLDLIGKNFGIAPEPTKNLENNSQRKLKAPRNFTLLNFVSQLRDRNLVLDFALIDDPFVSQGTVLMKSRGEISFGGLGGTPFAPPNVIIPQPQGVFMAEFFGTDFVANSMLYHAFKHKYMDVVVGPESSPQLKDVLLTTCSSGFCIGEYLGSLGQQFPGRQVEIHFSAKKAPIMVFVEGRARFRLHGKMDLFVRPENASQRLELVLRSETTMTSNVNLWIERNQILGNATVENLDFKLVGTNVHDVEQSSFADLGLFGAEFLEKLLTEILQIGLLLPSMRGVVLRSPKLTVHDRYIRVQTYFKLDEQYAERLVQGAVRQTLLNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY08</accession>
    <name>A0A914HY08_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY08"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5524.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5524.t1"/>
        <property type="gene ID" value="Gr19_v10_g5524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037663409" evidence="1">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5524.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39649" checksum="BDAD9CEAD61B36D1" modified="2023-02-22" version="1">MKTIIFVFLLVVSLSIENTVAPLSPNYVNNFQMPINSGGANIVEQNLSTPQNSKMALGRRKLSNENLILPKKFENGESKRKVSVPLEQIATEQNSSSMAKNVPETFLQNSLPFCQKENSFGQYLAELFNYYLSAGFPVPPNAIAKILLRMRKALEFYFLKRKNNSLFLMELPYPLTLENFRVDKTLHDSSGMSGSVNISFVAECKVCNINDLTLNRLFTMSPQQISEMRLKSDKSDIDWFFGSVLHLLLYQTYPLEQWMLRNNHQFGGDLTKLPNFEFVYMSKLQESVKELLESEGQLQIRNDLPRGFQKQYAFLGQIMKNALQTYSDTRTYDENQKMLKLASEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY93</accession>
    <name>A0A914HY93_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5215.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5215.t2"/>
        <property type="gene ID" value="Gr19_v10_g5215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001641">
        <property type="entry name" value="Myoblast growth factor receptor egl-15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001689">
        <property type="entry name" value="Myoblast growth factor receptor egl-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF550">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="59"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="360"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="467"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="730"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="290"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="669"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="836"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1091"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1168"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1210"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1325"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1096"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1106"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1212"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1222"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1243"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1357"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5215.t2"/>
        </source>
    </evidence>
    <sequence length="1419" mass="158372" checksum="2AD4DC50695B67CD" modified="2023-02-22" version="1">MISFHFHSQHFANTSSFPFPFLPIPFGTFLLLLVLVNIATPSRSASRDIGEHFARYGPPRFKQNARAHQFAYLGDTIRFKCNAIGRPQPRVHWYREGRYLNYSYMLRHPRLKERGMSLEVKRIEVGDGGNWTCRVWNNEGSTNRNFTLHIVDFCDYFLNVHIHPRRVPEKCLCQWAVQQRESLQAHDPLYLRALPQLRADLDLSEFIANNGSRCAHYAKVEEIARLRTQPREDAPKGWADEKSHQTDSTATSTSSTANLISTSTKSAVKWTLRKLSAKIRLANKIMGEMKQKDVHDGDEEDEDDDEEERHRDEWRQKADRITTTPATTTTNRTPWTTRTTRAPPSWAATKRWSLPQRVPPYFRQLDEQTLTHIVIPAGRTLKLSCKAGGQPEPQVVWRKDNEEILRDTESKTGSLFQLKKWTLELEDATENDSGEYVCEVFNSAGLIVRRFRVEVQDRIRSRPILVPNVLLNRTVDVNGTVDFSCQVISDLVPHIVWIKLIKNDGTFIRWDTKRKQYTFNFLDMSTHKRARIFHDKQMNRYTLEIVNVTMDDQGIYSCVAGNTLGMSMANATLTVNEFRPLTLPTDVSHSWPLSYTVLVILSFLLLCAFVSLGMLYLFFSKKFSAKNRVQTLDSMSVRKKVVITKKPQREGDFWSDLASSYSITVEPVPVRGRGGRTKGGSTGDLVPLMEDGQHGAQPTSGPAGETEDTSPLSEYEVPTDTAWEVERERLQMVDILGEGAFGEVWRGQLSPKSSEEAPTEPIPVAVKRLKTAAQERELIILVSEMQILKSIGHHPNILRLVGCCTGLGPLLVVLELCGHGNLKDFLRKHRPMELERGQSLDGYVEEGESTTGPEGTEKESDRSESKRSHVGKLYQNMDSPGTSVPMASTSAASTAQMPNRQLTLRDLVRFAAEIAKGMDFLASKKIIHRDLAARNVLVADNVIMKISDFGLSRNVFYNDYYRKRGAGRLPIKWMAPEALEANVYTVHSDVWSYGILLWEIMTLGGTPYPSIAMPQLYNLLKEGYRMEAPHNCPEEIYEVMVSCWQDRPEARPAFRTIADYFDWMLKESENYVTRTSDGETTDEGPYAVITERQNGKGRGGGGAKGPEGRDGGTEEAKGRAGQCFQDGTEASGGGTQQRMLSKRPVSAPGMMSFEKFSREIGIGSGEALPRALHSDHPHQQHKSAVATSPQAKSLPPRPERRFLFDQEKPLIELGSESSGAEGRAEEMDRGRSRAETKAGNVYKNLQTPCRSNEYANTPSPCPSAALTGIHQRSGPSSSAEAIPPSGCHAISQPPKQRSKKSVTSEHGLRVQGVLFTGIAQQNTNLVSGGWPRRQDGSSKGSSLGVRLGDWRSRSVDSSSSGHGGSSAMSSAEGLLGGGAATETEGPEEGEDQQQLQLEPEGVADNYVSIASIGHLSLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYD8</accession>
    <name>A0A914HYD8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HYD8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4936.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4936.t1"/>
        <property type="gene ID" value="Gr19_v10_g4936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4936.t1"/>
        </source>
    </evidence>
    <sequence length="566" mass="64844" checksum="BF4CF63DFFBBFE35" modified="2023-02-22" version="1">MSINRDQNVVEYLCGKIGSILREDSFDYVEHYGEMSNAALQTLMVGRGRELYVKLQAMIGEHLQKMHQQVFISSFTTENKSVDGIDDRILQSLCRQWFEFSEKMIIVRQVLLSSERVFDNSVGEESLIVFAWRIYRSILEQDSEHLPKLLNIVDVRTPNRKKSNILARSKVNQSVRRRSLFSDDTLFDFFRFVDTASLGLSVALCCRRFANFADSVLRGRTHSDCALMLCDGQNDLFPPPKKSENPIGAFAIRLWNSNGAKVNGRGFGRHIYHHGMLIYQVIDQWFSNPREQQPLDLSEIEIPEWITGMSFLYMPIGVTPSVLSFLQLISPMLQNCCLKFELASLWPKLHTSGQLLPFLSLFNPLTFSLQLTFDELSFFRVNNHFYKLPLWATFQSIFFPNCFDLSLPLSLLSSREIGIDVATWLHNERSTVGRPRRVVFSDQPKEINSMGQSFMPGVNAMIGLIKQKFAEGSGKRHFVVESSSKLLNEWDERLLQNGNSECLLVSPKRIVRCSIGDEHTEFEQFHDHLRNGKGTKVGPTVQIGTSSSVRWLKEVMAQMPSQTKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0T7</accession>
    <name>A0A914I0T7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0T7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5824.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5824.t1"/>
        <property type="gene ID" value="Gr19_v10_g5824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5824.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9048" checksum="79233F71F8B771B6" modified="2023-02-22" version="1">MDDIGTGNLAYEEIGREINEGLQVSGKPLDERLIHLAKAEEMILKQDEGALLCHFVYREGLQERLRSIQKSHSNIKLGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I155</accession>
    <name>A0A914I155_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I155"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5647.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5647.t1"/>
        <property type="gene ID" value="Gr19_v10_g5647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5647.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="20873" checksum="48D12931C56B301C" modified="2023-02-22" version="1">MIIPASKDKNYIPCSQLFVPPVYQFVLSPQVRASAFVATLLARCSLFSAAGRELADAQSVPCHAVATCGILGEGKNPQECGNPRVKPCWGVGQNWDMKCGNFAKAQKGVWRWHWGKNGDIENRGETLGLKGPKVWGRSPGGQWANMSWEGVAQRKKFGRAGPQAVRGEQQGGAEQMFEGKVQLNCLIVGTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I156</accession>
    <name>A0A914I156_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I156"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5912.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5912.t1"/>
        <property type="gene ID" value="Gr19_v10_g5912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5912.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17046" checksum="3B6B548AE8A4BC02" modified="2023-02-22" version="1">MDANFLADSPNFLMPIFRLVCSPSLVTIALAPMTFVASGAAGRHLIDPPGGSSSSPCPAHPFAFECDHSACCASYHQRFLMLLASLAIFAFALLVLVVWLAIEWRPQRWRRRSHRRGKRMSEVEIRSSEETRYLRRMSELNPNVRREVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I378</accession>
    <name>A0A914I378_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I378"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6413.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6413.t1"/>
        <property type="gene ID" value="Gr19_v10_g6413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="163"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6413.t1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41297" checksum="471469F47D5D6609" modified="2023-02-22" version="1">MFAVHPSSNKYNVSGLIKACVDFPKAKLRNVLVALGEARYLQREHIDVNVGALILSEEFLQIDQKLLCEILDRDELMINEEIAIWNAALCWADEKCRQNGKEQLSAENRRAMLGPALVKIRFPLISQEDFSEIIVPSGVLTDAEKLSVVLHYLSPDRALPEPYQLKFPTNGRAGTKSGLTLQNRWDSAACHEDLTLIEPNRLIVQNTNPLIIQNNGDDEEWCSVLAERPIPTGKFGIFYYEVKILVEKYDFLFGLGTKKMPLDKWVGNYKGTCAYDGSCHFWGHAAEGCSYSYGRPCIDGQPKFGTGDVVGCGINLATRQIFYTMNGKSLDTVDLFVDSAPDELFPCVSLLHSGDKIEANFGPNFEYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3B6</accession>
    <name>A0A914I3B6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mic1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3B6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6927.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6927.t1"/>
        <property type="gene ID" value="Gr19_v10_g6927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009755">
        <property type="entry name" value="RMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049040">
        <property type="entry name" value="RMC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07035">
        <property type="entry name" value="RMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21029">
        <property type="entry name" value="RMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator of MON1-CCZ1 complex N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Mic1" evidence="2">
        <location>
            <begin position="377"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6927.t1"/>
        </source>
    </evidence>
    <sequence length="756" mass="85851" checksum="DA8681B8F0A9FA8A" modified="2023-02-22" version="1">MLNIGANIVNLRTNGTKNIGIFYDSVTERVCTIRTEGEQLTITAKSADRAYHEILFDIREKFGRVRAVGFSSDLQIASIQQEDSVVEFAVLQDGKVVANFQHNCNFKGAVILGVHWLSNRQIAFVTEAGCEFYLVNAYKRVLKSIQRLATVINWFSFHAPSNLFICSSGVKNDTMTCLTFQQNAPHTLGSFEVDFGFSSAKPRLLERDIGVSSIYGKLCILVLKFEAVHGFATGLNVYELVPSEPQTPQLKCFLRLDLVGLVGLHVVDNLILIHHKNAKSTLVFDIQLSTERPICSTQLHMFSAVAYGANDAFPLKNDNDDGILNEIHWLRLLPDTFLYNSAWKMSLPDVVLEYAEHTLLADSAHDLNFLVRFLINRRNGESVLLKLLQRAILHKSLKFARITQIFRQILQGALQEDDVHKESGVESLAASTPKWFPPVAPFAPITVSHNSLLRSVFEPLHERQDEVDKQSLASLMMEFFLILKRTNVKVQETYVSELLVKMLVAADMFDRLQQLLQYSVIEKSKFLAYELITLSSRCPALYQIGLDMLKRRHDWEQIVEVLMTRGHLLEALRLLLNAQIDRVVLNKTLRRLLDLAWKSADRQLMFTVFSHVLYVQGRKQLAEVMSSDDFERYAQEFKLLYDREEVEEAVQRFRKARLSSIRRRSDTTARNDSFTFVPGDEEDDVLMKEGAEEDDINSIRSGRGISGVTGIEQQQETATDTDISTRSSSLPAQRAQTSLHMSFCTVETTIIMLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I466</accession>
    <name>A0A914I466_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I466"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6656.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6656.t1"/>
        <property type="gene ID" value="Gr19_v10_g6656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6656.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7817" checksum="DB4CEFF5146F2FB5" modified="2023-02-22" version="1">MIGLKFTGKSLLPAAGEDTHSSKNNKSTPYGFATPRRKIVDSASGTTTKGPETSPVGRGQFYWTILTWLMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4D4</accession>
    <name>A0A914I4D4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4D4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g65.t1">
        <property type="protein sequence ID" value="Gr19_v10_g65.t1"/>
        <property type="gene ID" value="Gr19_v10_g65"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16983">
        <property type="entry name" value="CID_SCAF8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF4">
        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="5">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="669"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1099"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g65.t1"/>
        </source>
    </evidence>
    <sequence length="1198" mass="127708" checksum="FF8ACE63A2B8F2E0" modified="2023-02-22" version="1">MDSEMIQAFNKCLVSMQEAKGGLVSKQKVLEITKAAMNGVRYFKHVVFIIERYLAKCRQEFKVPALYVMDSILRQAKKQYKHKDVFAPRFSINLSNTVQNVLTCDSADRLKVVRVVNLWQAHQIFTEEMLEPVLQHCRASGLEVDPVRVEQLVKGDKADMLLYQPQFAERGLSFNSSGGSTGVGTTLKDLPIPIIPSEQTHRIVPPPPPGPPPPSTPTGAAAQNVHHQPSLEERLSQFKKLSSGAALSTMTPLATPAVPSLSRTNSVSGGTPTALGTSRSNETGPKTPPLEDQDHRFATGQLSQTTISSVEDHRPQDIGLSSMDVLQLLLTAVGAVVPPDIGARPDVLTKVQRLLNERVGESLEIERRREGNIKNLLSREFDYSDEEDEAVVQHGQNPQHQQSMGPLAGVSREKMVTIAHALLGDGSFQQELRQQFAVQQQHAPFQLPDFSLPPPNIGAVINGGGGGLPKMFMSPPKMTGTSVPLPPGTSPSGAFNMAAVPPPLSLMSLATNAPSSSSNRDQSPPSSSGKRQHHHHHRERDRGERDSRDRDRDGRRRSERGSDRPSASGRKRNREWSPSVADDKDLRRSLSPPGAKRERNEDGGGGGGGGRRNDRDKRSGGGRRERGGGRHDEEERGERGKERDQQERERRRIGLPSKPKAEHVLIASRTLWFGRIPSGASESDIVDSVKDIGAPEKVSLVFGRGCAYVTMPDRRLAFKIMDRMEKSIKVQNKNVKVNWATIPYVQDNNQLMINYWDMNQGFAQIPYTKLPPDGTVDLLMDGAWLELDTLPANLKDRYTNTGLKQQQQQQQQQQLMVQQQNLMLSATAAAQQLQQAAAPMGTTAVTVPQQQAVVPSITGLLPAAMFTQAAAAAAAAQMAFAGNLLPFTFPPPNLPPPPVSAGGVHQQQQQQHQAAATVTMPKSVLGSTVSALMASTPPTTTTPAGAAGMQISSAGSLAGGFANASGFGIAGFASSIGGGGGGGGGGGGAGGGRGKWTPRGRGGARGGGSGFQPRFSSSSGGFRPGGFQSGNDGGYGGRGGFRGRGRLWDGGGSPMGRGARGGRGGRGGFYSGGRPPFGDGDFGTGANREPFGFGALPPQSESEGNVPASSNDITQQKREIEAPPGASDSYASVGFGDGTKFEPKTLNAPPGATTSGPFANLGFAGDLPKLESMFGGQLQQQQHHHCSETETDAPPGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I553</accession>
    <name>A0A914I553_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I553"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6984.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6984.t1"/>
        <property type="gene ID" value="Gr19_v10_g6984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000034">
        <property type="entry name" value="Universal minicircle sequence binding protein (UMSBP), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565">
        <property type="entry name" value="COLD SHOCK DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565:SF20">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6984.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="15821" checksum="373DC4A02DBB28CC" modified="2023-02-22" version="1">MSSNVCYNCNESGHFSRECPQARGGGGGGSRGGGGGGNVCYNCNESGHISRDCPQPRGGGGGGGSRGGGGGGGNVCYNCNESGHFSRECPQGRGGGGGGGSRGGGGGGSVCFNCNEPGHFSRECPQGRGGGGGGGGGSRGGGGGGGGCYNCGKSGHFSRECPEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I613</accession>
    <name>A0A914I613_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Luc7-like protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I613"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7642.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7642.t2"/>
        <property type="gene ID" value="Gr19_v10_g7642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="115"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7642.t2"/>
        </source>
    </evidence>
    <sequence length="299" mass="35928" checksum="06D1CC54BE702E97" modified="2023-02-22" version="1">MTGSTIVQFLGRVKLFEYLLKVQFNSTIKMTDVMREMIAQLMGQQRAEEEGRRLPPFDHHSVCRAYLLGCCPRDLLSDTRLESMMSCRKLHEPAHKGEFNRSQEQKDLFYDIEAFEELEDAIRIVDSDIRRLQDKVKRDAEQNMDISEQQRTQKIFEMNEKIGMALVQEVDELKRKKRELEGEMRNINPATMQRLRVCEACGAQLNIMDHESRLQDHYGGKMHLGMKTIDQRRSEKRRTDDKDRDERRRRSGREDERERDRKRDRSRSRSRSRKHRRSRSRDRTSKSSRRSRSRDRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6L3</accession>
    <name>A0A914I6L3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6L3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7100.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7100.t1"/>
        <property type="gene ID" value="Gr19_v10_g7100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7100.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="15538" checksum="0BC60612811452DB" modified="2023-02-22" version="1">MAPTPTGKLFGTGKLFGTGKLSGTGKLFGTGMEGQDKLFRTGKLSGTGKLSGTGMGGRDKLFRTGKLSGTGKLSGTGMEGRDKLFRTGKLSGTGVGGSGTRCPGRASCPGPGWGSGQAVEDGQAVRDRNLGSGQAVQDGQAVRDRQAVRDRNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I775</accession>
    <name>A0A914I775_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I775"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8141.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8141.t2"/>
        <property type="gene ID" value="Gr19_v10_g8141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8141.t2"/>
        </source>
    </evidence>
    <sequence length="185" mass="21111" checksum="A70C25F68BA2043C" modified="2023-02-22" version="1">MHEKLFEVDGEVEKMNLRIASFERLSRVQFGKIIERMKSEVSKITENLDALQGRVILLEFEQEESSPQWMEDGHSQEHEQLPGEQNNAVNTDGGEECRIMVSDPFLGGISPLEGYDGNPTISFARWVAKLEDMLSLYPQLTEPQKLSRLRILLKGQARAEFDAMDTPPTDLSEVGQWGYFGKLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7N9</accession>
    <name>A0A914I7N9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7N9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7394.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7394.t1"/>
        <property type="gene ID" value="Gr19_v10_g7394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF4">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="27"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="660"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="452"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7394.t1"/>
        </source>
    </evidence>
    <sequence length="1152" mass="130158" checksum="186801B40CA6CB85" modified="2023-02-22" version="1">MANGTLRSLSSSTFDERTQIFDKTANTMPSDEQEILSAFEEVLAKMDLPPDKMRTLRNCDIRKKWELVRGQLQFTHDQSITEPHVYLNQLRALMDKKSAKKKKKILAGDSPTKILKHLEISLRTNSIEWVRSFVSPENNGLQVVVDYLTHLQKSLVHPEIRQELSAYTSSIVATTSRGQQSAEYLANADCIQPKTPHQQHYLNASSASSVSSMPCKNNNNNNVYASGIIPSYTAETHSMKKAVASSALLANNKNNLKASKIKTQAEIEADQQHIILTIFRTLLNNRFGIAAMFSNGEAIYCIVRSILHSQLRSIALALDMLSGILCLDDDGAKHELVLNCFSRLQRQYNEPFRFQILIYCFKNPEAVNIDYNHPEAVKIEFLSSVVKFINLLVHTTVDMNQRVALQYEFSPIDNYLDVLKTAYETCELLTHCNAYCGNCFNVQVLYEKSMKCDVLEEAYERLKDDCSRQKEEFQVLQANCFVQVNMINQQKTKLAEDRTELERQNDEKITTLSRDWREKERKFERQRNEYEKRIEMLEKAEKEIKQGLKVAQHAAAQAKKTEQQVNIPPAIVVNEKVREQRESRQSERESASSSFVVSAPSPSSQPTPSQRPVPNPPPPPPPPPPSIQLKKPVQNGPKTMPPPPPPLGLFVSTSAESLPKKKIAKIESKMPMINWTALNPNQVKGTVFNNMNDEKLADVLDLSKLEAMFCLEQKPLSDRPESSANHQNVDNTVLSGAKARGQASPNSTTNSGKHSLLSTKRLQNIAIIRRKIGKTAMEIMTAVHRFDFTALTSDQVDVLLPIVPTSEETAKLQEYAKHNNDNFESLTAEDQFLAKLMDIERLERKLTLMKFMSDFVDNVRLLIPVLQKVTAASKRIQNADKFPKVIELILAVGNAMNGARRAPVYGFKIASLDSLNIMKSPKDRNCTLMHILAEIITDKFPELQDFTRELKLAESAATVNFETIVADVKEIDTKFEQILTEQSRKGKDESPESLNAFIESSSSQLISLKENFKLAQQSFLECSLYYGEGSSAVPDVFFSRIASFCKHFESALGELEAQKASEKRQEQEEQRKKSVLLRRNLKAENGQEKVIDELSQKLGQRNLNSFKDGDFEILMAELKETGFVAPSTITVKEMINKTNNMMIFLTTCPSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I809</accession>
    <name>A0A914I809_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I809"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8141.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8141.t1"/>
        <property type="gene ID" value="Gr19_v10_g8141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8141.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27584" checksum="FD3FBEA3876FF235" modified="2023-02-22" version="1">MRSFEQAVCGQFRQIDAKFGQITNQLRIQDTVDRVRELDSSIKELENIRESDTFQMHEKLFEVDGEVEKMNLRIASFERLSRVQFGKIIERMKSEVSKITENLDALQGRVILLEFEQEESSPQWMEDGHSQEHEQLPGEQNNAVNTDGGEECRIMVSDPFLGGISPLEGYDGNPTISFARWVAKLEDMLSLYPQLTEPQKLSRLRILLKGQARAEFDAMDTPPTDLSEVGQWGYFGKLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8L5</accession>
    <name>A0A914I8L5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8L5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8496.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8496.t1"/>
        <property type="gene ID" value="Gr19_v10_g8496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8496.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31414" checksum="650B482C02CE9434" modified="2023-02-22" version="1">MISDHSENPNLCYRWTKSGKAHISGLRYVCAGCRKLRDAKRVAKETPLPTRKVVGGEWADDGPSQQHFCQPFERTKVQGQEERRKVQAELAFGLRENVASARVRIDARVAQNYSDRAEEERNQIRHNACGNSKATTQALYRAQTKRLMSVMTLHGLASVGRWLVNFQEANQAGCEEEKTVVAIEDGQQQPNQPLAMTAEVDAGIEREKADVLAFLNTDFEEEQFVETLSRYFVRVGQLTGFNAPTNVEIDEQMQEDAVAEASLDESGIVQSIDEENIVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I913</accession>
    <name>A0A914I913_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I913"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8398.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8398.t1"/>
        <property type="gene ID" value="Gr19_v10_g8398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000420">
        <property type="entry name" value="OCTopamine Receptor (GPCR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF174">
        <property type="entry name" value="TYRAMINE_OCTOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="109"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8398.t1"/>
        </source>
    </evidence>
    <sequence length="576" mass="65396" checksum="7DC62D9D374B797E" modified="2023-02-22" version="1">MDPHSLGSSPTTSSLPPLLFNNNNVVIIKQYQNTGLFINNNLTETLTSASRAADPRQFGDGSLIILLHGAAEWCPNVSNAVVWPSCITLPEALAMSFFVLIGMLVIVLGNLMVVLTVSNDAKMRGQRQNWLLVSLAMADLLVGLLVMPLTLTYEIVGVWVLGSVLCELWLALDVLFVTASILHICIISLDRYWSVTQPLSYPAKRTPRRISVMIGVAWLVSLLICFPPLLGWRPKRRPGECSVSSELDYVLYSSLGSFYIPVAILVVVYMRIYMITKRHSQQRLKDTQRMGQTLSQLSGGNKPMTAHRVAEAGAGIGRTKRQIKFCKSIPLSADEVSSPDPSTSMWPTPKAGGREQQQQHQQQNNVVDSKTLRNGGPHVQHQQQQQQHNNVNNRTTKEQSNDDSNESATTTMAFDEEHWAAEHDGNECRKQNKRNHFLKHSDKTGTVPSPRFTLLARLFRKGCTDDSTVQVVRMRSLEKRKRRLKAKERQATLLLGLILFAFIASWMPFFIMYVLNALHIYAPVVVFKFFFWLGYCNSAINPIIYTYFNREFRRALLRLIRRHQHRFHFLERFSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9V8</accession>
    <name>A0A914I9V8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9V8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7955.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7955.t1"/>
        <property type="gene ID" value="Gr19_v10_g7955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097169">
        <property type="term" value="C:AIM2 inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072557">
        <property type="term" value="C:IPAF inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072559">
        <property type="term" value="C:NLRP3 inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF3">
        <property type="entry name" value="CASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="5">
        <location>
            <begin position="781"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="4">
        <location>
            <begin position="937"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="681"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="906"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7955.t1"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114631" checksum="27EE081CCF1090EB" modified="2023-02-22" version="1">MEILSIPPPPQQSVLCDYRLLKSGPFTPPPPRALPSQIRRVLLHCKVNGRKRAAAAAAVASSSSCSSSSSTVDESAGRRTSNDEDDNSRRLRPFLGKNPGGDKRSDQQLISMFGDGSDQKAARGLFSTNVRAPTCQTGRRGRCNSFANGNTCSTIATTTRRTITMWQFCRHDICRATNKYDTLGLAELGPSLRTTACQPRSPSRTSLATCSTFRMTTSGSVPSSCRRSTNTVNTSWCPRWNGMAQTQCLFDKPTERRYYEKMFETPAPGAFYTVSQQCKFVFGAAAEISVHSVLSSIVVLRKLGVEHSTCLWPTRRPAGTTCGAIGDNVSACRQCSSNSLTEDGAIGGHGESVRAHAEKVSKRHSGIATRHDPRMAANIVLGSGSAIGHAMFRTAPGTCPVLMSFNDSDIGIHGVPKEMKWAPKYTGVGDNERCRLYCRGTDSAAFYLLKDTVADGRPCDRNGDDICIDGTCHKAGCDHRLGSEMKRDVCGVCGGNGSSCRAVNGLYNERSTFGYNEVLRIPAGAFLQFFARAGANRAPAVGAVVRTRSQWKRAVASRGNAFWRSKRRLPPLETRFVESVLHQQCHGKEQKQTEKCSPGPCPYWRAAEWGQCSVRCGQSFRTRHVECVLKGQIVDDSLCMEAMRPKTNDRCVLLACAIWNAEPWSSVHFLLKHFDWHKMSKRKSRRRTPRERKREQTTRKTNQESSESDSEVGSLDYSELESEDSDTPLSPISPVEIAEEIEAGNFANLKTLLFKSMAEQSVRQWNVDDEDEVYSPNLNVIRGRALIINNHKFTRMKNRDGTNVDRERMFHLLKLLRYDTTIKDNLRARQMLKAVAKFSKEADHNSADSVVLVILTHGSSGKLFGIDDKYCFVDDLLGPLNNKNCGRLAGKPKLIFLQCCRGGKTDTGVSHGRNESATRAQDQRRDSPRRIRAPSEQLRRLPTDADFLICFSTTDYRVSWRSRLRGSRFIQAICECFARYAAVDDVLHLMTRVNGVVAAMYSNRKLSFMQVSEERYTLTKLFFFFPNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAQ8</accession>
    <name>A0A914IAQ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAQ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9080.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9080.t1"/>
        <property type="gene ID" value="Gr19_v10_g9080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF5">
        <property type="entry name" value="C-FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9080.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="19204" checksum="9204B54EC9C6FD19" modified="2023-02-22" version="1">MQSSLPLGANVFLTGANRGIGLGLVKEILKIGGVTNLFPGCREPDQELKELAKCNKALKLVKIDVSSDESIQNAVKVLGSDDGLNTLINNAGILEKGGTLKAPDRAVYLRHFNVNVVGTVATTAAFLPLLRKTVAPAAAANSGAVVRVVNIGGPLGCIGKVFLTPSECPYQNVAYGMSKVMCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAZ1</accession>
    <name>A0A914IAZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9156.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9156.t1"/>
        <property type="gene ID" value="Gr19_v10_g9156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037276530" evidence="1">
        <location>
            <begin position="27"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="30"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9156.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="23365" checksum="D2F520A7920E489A" modified="2023-02-22" version="1">MAFAPTISVLCLLLIALSEMPFSVMALSASSRVSVLACHNNYRSTLAKGTAANLTGTMPAGSNLIQQKYSTSAETTAQNWANGCSMAHSSSSSRNGMGENLYMTSSSTITEADALKQACDMWWAELKQYGFQSSLVLDMNQFNKGIGHWSQQAWANTAQLGCAMARCPSSTWKTWVVCNYNASGNYLNQVVYKKGTACSGCSDYSGASCNSTSGLCVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB95</accession>
    <name>A0A914IB95_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endostatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g8613.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8613.t1"/>
        <property type="gene ID" value="Gr19_v10_g8613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010515">
        <property type="entry name" value="Collagenase_NC10/endostatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045463">
        <property type="entry name" value="XV/XVIII_trimerization_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20010">
        <property type="entry name" value="Collagen_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06482">
        <property type="entry name" value="Endostatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037755099" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen type XV/XVIII trimerization" evidence="4">
        <location>
            <begin position="920"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Collagenase NC10/endostatin" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="900"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8613.t1"/>
        </source>
    </evidence>
    <sequence length="1299" mass="142763" checksum="B6A061626D589F45" modified="2023-02-22" version="1">MFLPLLLLSSVFTPPAIALSSAASANDASSSPSPLMPSTPEWQSVPDDPTLAQELEREEEGSGVEVIAAAVGDTETTNWVRVVPTEVPDDEDKVETKDEELLEVEQNETEMEAANGQKGTNSKGAGGEEELTGQVNDVQRVGAVHPPQQHQQQQIVRTETTITEIKTVVREKNDGNQSTNEEGTERQQSVLKTGQNEVKTGQSVDKTEQNVTRTKESVSDVKLDEDSGQFVPFFEEADVDDDDDDDDEEIMENESLLQHEVNITRDETTKTPEVEEKPHIRKEEVGAVHPPQYQHQQIVRTKTITEIRTVVEQKNIVDQSDQLIKTGQNVTKTEMNNVLEANLHENFIKTGQNTNKTGTADVSGHPPHQQQQQIVRTEETMVERRKTVVGMGKNVGNQSVIEEETKRRQNVIKTGQNTIKTEQSVSEVKLDENGERFTQIVNKAGDGLSNLNLTMLEVNISNYGTNKTTQVGGKVEERQHTRKEDVGAVHPPQHQQKIVRTETIVERKTVVGMAKDVDNQSVIEEETKRRQSLIKTGQNVTRMEQSVSADARREEEETKRRQNVTKTGQNVTVIKTGQNVTKTEEQSGMSADARREEEETKRRQSVIKTGQNVTVIKTGGAKGAAEFGRNASKIGLHDDPSEAANQCNENWWKTRRRDFSHHKDTERDGGAGGEGSGFGGPSFDNDDAGGGERSMPTTERPLMSTTSTTATYTTMAPPTTATTAAMATRAETRPSAADRWDGALSGPQGQKGEPGVPGTCASECRMPPPGPPGLPGAPGVSGLPGVFTGLSDADVRRIVKWPDVKGEKGTCMERHSDRGAGTDSMARHNQRREEGENENALELLMNGQSGDIAGLPPYDSRIHGDGQQQPRVGQKGDKGDRGVAGTAGAPGPPGPPGPVPRQQQQQQQQQMPQSPVAATVSVYQTALELLAGTPKCPIGTLAFAISTQQLFLRVHSGWRQVLLDPTILNDRQPPLTPPQQRQPLPPPAPQFRHRPATQSELLEQQQQQPTEDPALSRLAYWLALDEPSGAREDEESESAPAASRGRGPEGPEGAEGALVPIGRPPLLPPTAPPAPPRSIPQAQPWRTAQLPPKGWKSSREEETEKPSIRHKDKVIHLMALNEPLLGNFGGVRGADLECYRQARQAGFSTTFRAFISSRVQDLNKIVHAEDRQQTPVVNLLGERLFDSWHGVFDGGAHAHVPLYTFDRRNVFNHRDWSDRWVWHGSSSGGLRSLAYCADWRSTKLNTFGMASPLHSRHALTDQSREMPCNRRFAVLCVEVMSKHSVHQKLGKRFMSDLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBV3</accession>
    <name>A0A914IBV3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9169.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9169.t1"/>
        <property type="gene ID" value="Gr19_v10_g9169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9169.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19508" checksum="1FDCADF0D6DFDACC" modified="2023-02-22" version="1">MSNVLETISGDTVQFHSAEWYLDADFQFVHRDLNNSFKNGCLCLFILLVCPFTSGFYGESGISIFVAAVSLAITMAFVVVKLRTESLTYGLLAIGLILCALATILLNVHRRVLQTELEAVLQTNSVPSTDPLLIFFVAMALFLASAAYVVDIWVVYRQRRWRTWIVDRSKYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDW2</accession>
    <name>A0A914IDW2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9320.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9320.t1"/>
        <property type="gene ID" value="Gr19_v10_g9320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9320.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18171" checksum="CAB353E28784C563" modified="2023-02-22" version="1">MTGINYYRRVNHRRVGVGESTTGESASASRPSASQRRRFDSTIGESTIGESASASQPSASRCRVGESTIGESASASQPSASRRRRVDHRRVGVGESTIGESTIRESTIGESASASRRRPSASRRRRVDHRRVDHRRVDHWRVCVGELNCSSFRSPESRPTYWPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE74</accession>
    <name>A0A914IE74_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914IE74"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9401.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9401.t2"/>
        <property type="gene ID" value="Gr19_v10_g9401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9401.t2"/>
        </source>
    </evidence>
    <sequence length="481" mass="54410" checksum="9C0585C30437A79E" modified="2023-02-22" version="1">MALKILFVQPRYAHFRSHFGFGLSLAELLAQDGHQVHILAPIREENDKLIGETKEGVTIKYFEATKPKESPLADNSYIEIISDMELMNKLKAEKYDIGIAEAFMLTEYSLAIFYFLEIPETIATHSQPMSPVQLYLLGVMSKMKSGKFLASVGQPTLLLITNDEERRKVIGTRIGDHRASQLEKRGPEIWEHCVNQTSEKLRQHETQDKLYQKLADKKYGGKIFPGWAELFKRTRFFLVNSQPEVDFGKFEIVKDVEKVKFIGGFDLKEMASPKLNLPVGLEAMSKKGVVLISLGTNVNTTKPEFSYIIEAIKGAVQKFPNFFFIWKVTEGHPMNTFRNLGNVMATIWVKQKEILAHPKTMAFLSHCGMNSVLESTYYGVPMVCVPFFGDQYYNSESLARQNIGLVVDREQKDTVEQELTVALAKALGQKEMLETVQNFSDSEDQIDLGKVKAVSEALRQKESTKTISDAIKEIGNELNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE83</accession>
    <name>A0A914IE83_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Guanylate cyclase</fullName>
            <ecNumber evidence="4 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4 16"/>
    <dbReference type="AlphaFoldDB" id="A0A914IE83"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9087.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9087.t1"/>
        <property type="gene ID" value="Gr19_v10_g9087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000050">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF503">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="514"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="21">
        <location>
            <begin position="952"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="689"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="889"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="699"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9087.t1"/>
        </source>
    </evidence>
    <sequence length="1148" mass="131110" checksum="8B335FE64ABDC16F" modified="2023-02-22" version="1">MITGDNVLTAIHVVAEQLDNQHKRTRMAIIGFGVLITIPNNPNIIHEPLVLKMCANDLKERNLLPEGLNLQVYTMESCNRFSGVEHAAYLHYLRNASVYFGPGCNNEMLIIGRLVSRWNVPIVAHLSGDDALADRNVFDTLGSVALTSATEMARATITFLHLYGWKQIGIVRSSVNYDRLSVHSLKNSLKDNKIEINTEIEFDPYMSADEIIATGRLKHLRNRARIIIVEMGMDLHSVTAFMVAIHRSNMKTSEYVYIIPWLAHMNDHYPWESTNVEKQEVKSAFDDAIVITAHGYDKKFIEDFERRFNLVAGVVSNHYATLSYMSLYDALYLYGLAIRDAFEESKSNTVYLDGKIVWRKMTARQFIGATGQVLMNNKAIRVPSYATYHTKNGTMKIVVELTARLGDRLKCLKSEHDCSEHVAHEVLSHYWSSSDGYMPTDMPRCGFDDSLCDYTVMYVVGSVMLFLAVVIPIGYLLYVREKERMLYDMTWRIPREQIKLLLDGKHSRSRRSDPSMNKSFESTSVGSLFANSRLSVPQAVANGVKCSCKRYQQTRNISFNKHDLARLKELKMFENENLNKFYGISFNQQNEFIVLWVLCQRGSLEDVLFNGEIKIGRNFQVSFAKDVVKAVYFLHMSTLRMHGFLCLQNCLVDSNWNVKLTSFVTEEIIGDKLKHNELKYVDNGELEHEIKQRKREKRERREQRDNGATDQPAEKTDKVKEREKWRKKRDSDSDMGHDSLDVDIAAIKMREKSSAKKLVQQAPEIVREYVSSKHLPVGTQAADMYSLAMVLYQILFKLEPFYERNLPYNKILSKIAMANDNDQIIRPSFPNQQNLPNQREEEELDAYNLQLLSAIEACWLEIPEMRPNIKRMKAIVFANLKSSGSGSLVDQMIKMMEDYTTNLEQLVKERTQMLEDAQQQADRLLKSMLPSTIAEDLKAGRSVLPQLYANATVLFSDIRGFTRISSTSTPLQVVNFLNDLFSGFDAIIVKHDAFKVETIGDAYMIVSGLPRENGNAHVQHISEISLKMRTFVSNFKLAHRPEESLMVRIGFHSGAVAAGVVGLQAPRYCLFGETVNFASRMESTGLPNKIQISEHSFNLLRCFYHQFVVVERGKVDIKGKGEVTTHFLEGKEQSSFNLGQQQSYGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEJ9</accession>
    <name>A0A914IEJ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEJ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9897.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9897.t1"/>
        <property type="gene ID" value="Gr19_v10_g9897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9897.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25978" checksum="D79BFDC4A6C5D461" modified="2023-02-22" version="1">MSSQPSFPPISQEMARKNCLDVLDQLRTYMKTKNANAIKHIGEILTELGLDHITPAFIKCVEQKSICQNCGNQVVNPDQLCCCPDSTERCHCTGSCCDKRKIVAGGWPMFNNASGVHHQQEPVFPKFGEVLTMTKCEGLAEMMEQLTVNVAAHGGLLQGENNDLLTSINKELADAGLNNMMDAFNRALDSKCMCKMCKKQLELNDICYCDDAKIKCHCNSRTCCTVTLKEDGKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IES5</accession>
    <name>A0A914IES5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IES5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9940.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9940.t1"/>
        <property type="gene ID" value="Gr19_v10_g9940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9940.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57569" checksum="48C3152F5E70E7DC" modified="2023-02-22" version="1">MLNSVGCQPCPTTAALFTSASFGPPPPAECSAMPMPSYSAYPPVVHLHGHFFLQHPPQHQQFTHSSDQLPHHPVHHQHNSQQQQQHYHHLSYQLPQYSTPKCASFGAKTDYEGWTSFENNGAAFGQGTAMAEKTVPPTTSSSNMAHFEANPAETFFNFKTVPSSYHCASFSSYGEHPADGNGRMGNEANVQKEKSPKNHKNTIKKNGVQSSGRIPKSAHRRGDTGGVPQEDGGRKRTAGEGPMRCRWLVGVGEERMECGKEFVEMEHIVEHLDTEHLGTSAVTPMGTEDGSETFCQTVHICRWEDCVRNRKEFKAKYKLKNHLRVHTGERPFTCEMCNKTFARSENMKIHVRTHTGERPFKCQNCSKFFANSSDRKKHQHVHQPQRKPYRCDQSGCEKKYTHPSSLRKHLRLHGKMMCPNLEALKDGPFGVREDDSNLDRTLAEQTPTELNNSNPARVPPQTQHLSASGNNGTLQLPFPFGHFDNGVHHPPYQLYSHQQIPHLTSIGYHGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFS3</accession>
    <name>A0A914IFS3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFS3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9837.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9837.t1"/>
        <property type="gene ID" value="Gr19_v10_g9837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9837.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11376" checksum="E0561A7E3BB98BCF" modified="2023-02-22" version="1">MTQLGRVSEKESMKLSKVDAAVHPEWAFNFEVRAYPTLKLFKNVFVLECNAGEAEEEAKAAAVPARAAKAVGEKKLVAAVKTAVEATVVNNNRAVTELAAELGANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPD0</accession>
    <name>A0A914GPD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1019.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1019.t1"/>
        <property type="gene ID" value="Gr19_v10_g1019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037884366" evidence="2">
        <location>
            <begin position="25"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1019.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="19850" checksum="BD09C9A9F5D29C9A" modified="2023-02-22" version="1">MKNKMFLLLYGMGLSAMFVELSNAYLYGGNIGHVAETALVRVRRQCGCGCGGGGGGGCGGGGGGGGGCGCGGGGGAPPAPPASPTITLSVGCGGGGSGGGGGGGGGCGGGGGGCGGGGGGGCGGGCGGGGGGCGGGGGCGGGGGGCGGGCGGGGGGCGGGGGCGAPAAPPASPTISLSTSCAAPAPPPPPSGGGGGGCGCGCGRRRKRLAPNYKPRRHMARNWRRYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR17</accession>
    <name>A0A914GR17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">TFIIS N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GR17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10395.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10395.t2"/>
        <property type="gene ID" value="Gr19_v10_g10395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000001">
        <property type="entry name" value="IWS1, SUPT6H interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="690"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="896"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="925"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="17">
        <location>
            <begin position="305"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="572"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10395.t2"/>
        </source>
    </evidence>
    <sequence length="1137" mass="128891" checksum="9FD2F8BE87B644E1" modified="2023-02-22" version="1">MSHEGGEERRVKEEVVQESSVKVGEVAHEGGEERRVKEEVVQEMSHEGGEERRVKEEIVQEMSHESGEERVEEEMSHEGGEERVEEEVVQEMSHENGEDRVEEEVVQEMSHEGGEERVEEEVVQEMSHENGEERVEEEEAQEMSHEGGEERVEEEEAQESSVKEGEVSQLMQNIFGDDEMSEDEEEKNKESGDEDEPKLIRVEHAEEDVEQDSLGRRWDFDVMLAKKKHDRRHRRRKDGSIDLMADADDQIRALVGAMNEAANEDRVSNMDRRPAVKKRKMLQVVKNALLKTDLFEAMLDNGMISALSEWLAPLPDKSLPALEIRCTLLKILENWPNLEQSILKQSGLGRAVMYLFKHPKETKENKLVAAKLIREWSRPIFQLDSDFRSLSKEERVQRDFSQMPLAKKRRLSMDNDESIFAAAHKQPKQQKEAEVEATRPGETGFVPRARVPRPSTCDYVIRPKPEIEGQFRGETKNKQTSRFSKVQREMRSQKTTKRAFHLSLVDLSHSLCFVHHRTRMSKDRSAVDGERVETSDGTTNDEPPIVRVGMAEEIYAGILSDGSDFGLYQCLLFLFTQFGYLAVAPSMLSTTFFEPSPSFCATLRYANGTLPSPSSTDEFHSLLMEWDEHCHFSPRTVWMSSAVMVGAVIGAFVAGFVADRFGRKPVVVGSMALVSVGNSLMALWGSFSPFLALSLYALLGLACGAYMVTNMVLLIEILRCSSTRLLAVSLNGWPLGMIGTALLAFGLRHWRYYHLAVSITALVLFIIIHYLAFESIPWLMQSGNHRRAHLVRQNLFKVNSFLAKDKTVAMLEVNDATRSSSPLSSLPEFGDALLEELEEDTQTAATQLQRVYTYLDLFRQRSVCVRMLTLLFCFGASSVTSFGLYFSADVLPGSRYVNIAMMGVGKLILGFLPFILSNRIGRRPILLISVGLACLACWLLVVGWLFFSLSKHWVTAALGLFITAAIDPNWKIIHLLSMELFPTPVRNMSRALCNVVARLGSLSVPWVQFLRSHNGVLPFWLFGFLLTVQWLISFAFLPETVGQPLPEQMPSEDRRRHQNDGIEQRKCLTISAEKRSKKSLRKRTLSQQSHNSICSRALRKSKTQKYLKTASSRLAVLLSKGFILSRRTFPSCSSRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSR9</accession>
    <name>A0A914GSR9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSR9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10880.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10880.t2"/>
        <property type="gene ID" value="Gr19_v10_g10880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037133938" evidence="2">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10880.t2"/>
        </source>
    </evidence>
    <sequence length="252" mass="23848" checksum="7853650CBE82AD5E" modified="2023-02-22" version="1">MSKLSRTFIGLLVLKLVFAQWDGGMVGGSAMGGGMGAGMGGGMSGGGMSPGGMDGGGMGGGEMTPMGGGGMDGSMGSAGGGGGGMMSGGGDMGGYGRVQDTTRAGDDWEGLSCDGYEGGGMPMGNGMSGDNGGMGGGMSGGMGGGMSGGMNAGMGGGGDMGGYGSNQGGFGSGSPSGFGSAGGASGMLESARYVQSAQGMPPIQIPPYSAEEDGPASGNKNGLPPIQIPPYSAEELDEKNVKPIIKPLLPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GST8</accession>
    <name>A0A914GST8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LSM14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GST8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10893.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10893.t2"/>
        <property type="gene ID" value="Gr19_v10_g10893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="2">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="3">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10893.t2"/>
        </source>
    </evidence>
    <sequence length="486" mass="55094" checksum="AB25625AA68FD55F" modified="2023-02-22" version="1">MSTPYIGSKISLISRLDIRYEGTLFQVDPVESTISLSQVRSFGTEDRPAPVSVPARSEVYEFIIFKASDIKDLIVCETPKEPGVDDITYDPAIVSVSKPPAEASAKQPAAAVDQQRATDEKTSQRSSPQQQQQKKQPPLAPPPYIPPPNVPSAFQPPTQPQQRAAVAGDRLDLTKFCGVERVGSAQQSEPNLGGFGQRAQRSFFNRAQQPQTPGPLSNAHLNQQPQQQQNRRPYYPLRQPVQHQQQQEYHQQPYHHQQAGQIRRGYQPPANRQPYQHFRAQFQREQPRFDGDFDFEKANQQFQTIGDIGDKLAEIGLNEVEKLSSIHASGGGSARGSEERSISAGSEVGSNNNNNSSANKSLVPDNFYDKTQSFFDNISCDALEREEGRNNRMDWKKERITNQETFGQTAVRSMMHFQRGGGRGGGGAPFLYRGGYNNHHHNNNYHHQQQHPQYYQQRNQQQHRFGMQRQFQPPHHHQQVQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTV5</accession>
    <name>A0A914GTV5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTV5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11293.t6">
        <property type="protein sequence ID" value="Gr19_v10_g11293.t6"/>
        <property type="gene ID" value="Gr19_v10_g11293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031354">
        <property type="entry name" value="BRD4_CDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17105">
        <property type="entry name" value="BRD4_CDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="107"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="349"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="6">
        <location>
            <begin position="692"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="584"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="766"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="796"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11293.t6"/>
        </source>
    </evidence>
    <sequence length="1243" mass="138686" checksum="02B10439B469C433" modified="2023-02-22" version="1">MDQRKNGHQKDLEPGTSFDDEQFTKSNEADASHLSHHDAHSDTMDIGEGLPIESMNENDCPTKGWETPPQESVNGMVQPRVVPPVGKPTRWTNQLDFILKDVLKQAKNHKHAWPFVRPVDSIKLNIPDYHKVIKRPMDLGTIERRLKNMYYYSASECIKDIMTVFNDCYLFNPPHFGDFEQIFANCYKFNQCEDDVTLMCKNVENLYRDRLKKFPDKEVEIPFPSQKKAGKGSAKRNIRASSTTTKVSRESSAQRGLPDSSSSIGSVKLEIDSTEEQKGKGVKRKADTTTSFDEEGPSMKQPIKREVRPIKKGPAPVDYAQFKPLLKGKLNERMKFCQKLLNELITSKKCKAFNWPFLEPVDAEALNLPDYFEVIKEPMDLSTIKKKMDARQYTSPEEFRSDVLLMSRNCFTYNPEDQPVHKIGKQLQLYFNSKWRHLPADVPPESSQIALPTAALPPKEEKKDALPKTTSSNKTSSVSPSALLKQFKPVDDDEQIDFLLLQVQADQSRTNERQTQLQQFNHELMQLKLRRREARTHQQTPPPLSAELHTAIKSLLNACLPNSISSSFQLPSCTGFMPSLLPSSSIPQMPPATPTISLSQPTKKKTGPGRPRVTNSSSSSNLIGQQTTESSSSTPAQAQNIPVSQSHQIPAVQQQFTPLDAQSGRGRKPGSKNKPKTESQKEELSTKEYEFNSEDEHSSEPMTYDEKRQLSQNINNLPGDKLTSVVNIIKAREQIKDLNPDEIEIDFETLKPVTLRELEAYVKACSQPPDKKQKKASFPAKTLHSDQPKKKDSDPRIQQLNGGAQPNAKLSNGDGQLSVSSTTAFAGRPTQMLIAPNEDENSSSESSSESEEKPNQLKPPAPSVVQSADLHKAAIARSVLPPPLVQQQQMASQMIQSKSTPQIGVGGGHSHGSVKDLVAVTAASKAPTLMPPPSHVHSGAAPLLQTNNPTEISAGIAGSVLDHLLPSVTNDDRGVGIASGLLNKNSWSSLAQKAAEGGSQMSTGTNTTNAYELFRKQAREKEERKRQLKEEEERKKQQRERERQHLQHSASGESISAPVDGQQQQKVKISQEEVNRLREIEKERRKREEMEHVDMTSQMEVMANFEEITVVAPSNVSAGRQAVFGRPNEAPPLLSAAVVFTIIDLMDTEAESSTAFNAVEISGTIDPSRVVSDLMWLTEQCEQRCMFECVKWSVCCHFEGGGVSLKAMFDQLCASFDRQQRLRPSEFFLSNDEQMTSLEAFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTW2</accession>
    <name>A0A914GTW2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10723.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10723.t1"/>
        <property type="gene ID" value="Gr19_v10_g10723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10723.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14378" checksum="734432FA2E300A7B" modified="2023-02-22" version="1">MSRKFELFLAITLLFTAQPNKRSFVALAELQNHDRKAQIRTLPSVGLQMDRNVFQLGFGKRKQQQNVQQPMAALLLDRNVFRMSFGKREFNAFPLLKLMKGKAIIRLIMRELTVRKYNQAAGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUF7</accession>
    <name>A0A914GUF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10496.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10496.t1"/>
        <property type="gene ID" value="Gr19_v10_g10496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10496.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11820" checksum="F247442B4CAA66DD" modified="2023-02-22" version="1">MIGQQQNNKANGMKRPPPPPHLPPPNYTIVPSPLPSSASLLHLPNQTMCALLSQCSSVHTSYIFCVLCLFIHSSDFLRPFSMTQMEGGEEKAPTERSFGSDNERTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV91</accession>
    <name>A0A914GV91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g10718.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10718.t1"/>
        <property type="gene ID" value="Gr19_v10_g10718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="2">
        <location>
            <begin position="364"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10718.t1"/>
        </source>
    </evidence>
    <sequence length="1711" mass="195441" checksum="8169CF70B931C7E0" modified="2023-02-22" version="1">MVYDVIRTFVSKLSQLTNFAKSFKPSNSSGCSGSNSQQPSDLLNNTATNTAPSSSTTPAATFLFNVQSEHSVELSFRLPQNHLLRFILPSFTVERKDLCVANAGAPNLLVEMDGNLIMNVERPALNCVAEDLLMKMIRGGDLFGHQLELEANRLWSWSADSLEISFPYDYCFSDAFEEVINSIKWAKLVHGIVPKPFTKDSPLPADVRIRLNHLSLRLDDDPLEIQLQNIYEVQMDEVFERERRKQILDSKVAQLKKEDPFFPNTKVDALYRSLVKKDGQLYVERIRKVRQQLQERRPLFQWTLDDVEVRAVADPTLHGRDSVLTCIRNFNPESHFPVEHPEFSTLWARAVELEVSQSRMLFRDYPLPYMHLRKAHFWGTLVGAEQLMESRSVRQQSVHTPRPWGTFTINRNMCPLKFFYDLKCEINDLTMTYGPCWEPCLSMISQCWSLVNAPSKDPSVPLPFWDKFRLLLHGRFAMACNRLQTSMLASTDPYNDTELVEIVWEDFEFDWFTGEFRIRADVDAYIRTASKYDDSRLLHLPRLHCTIRLDWACLGDQHDHHSVQPCAPDKLPEYSSNIGHDSFRAFRSAYVNSVVHFETNSWEQLSRQCPHILLYANTFKCLDFLMRTLMTVNRPVKRGPLFKSPRIKRYQLSRHFKNVQLVASLPRFLISYWMSFSSSHGFRVISDSLQFACDFLLHIYPDQSNDGLTRRPKTAWKMLHTSAELENAQIHLYGDQRQPGAEEDLMNSSTSTDSANSSFFVGLSRLIYIRKSQNKRAHFACADDELDSSGHSSSEGFSPVQHGPTVAQTATVAPAPVHRLTITDLKASWTIDNRDICLVIAEGVQKAHILRKILNNEALKMFKFGDEGLSSTPISSSISNRFASATQRAAKKHSTAAAVRKMTKNNSNNFATGGITTAANGNGNTFGISPCHESVRHLHQHLQQQQQRSSMPPSTSSNLLQDDDHLLVDDREMLWRLVDEAESNLVAYSEEIAQNPTDSLNGVALCTMNDIILTNWQIDLLNSQLVLKSSETVGGFILVTAARASVTQHLHIPVWRHTQLLLKRSWNTVLSGMQYFAPVFIAHEPGSKLRPTEFHWLNRDVIEEKQMKTDQLHNKLDDFATTGEAVGGVVVDNKSSVPDGEDFDCPESAPHHLQLQRVASRCSCQLFFCYFSDLLDADDDDLLMFVVGGDSVDVPSSSAALAVAAPPLISTGDDHQHSPRQHRAGSKRERSSFGERRCEEADTFTLKHNILEVCTNSAQYHMCIDILQNLILFVDPRKTESEGNRRVHSKTSDLRELVSLVRSMERQAYFLNKEIQVNPHDAQMDSESVQLQHDIDEYKQRQNALIDELAMMVSCYKELTIMEQTEQFKNDLLRQQHEQGRSEEDEEEQKAELIARRFEVCFENCIWRLTENDGQISLSEVQIRNFLYTRTARIDNSGDHLLEIGIVKVLNLLPNSKYKETLARLQTTSSEGGVDVTPSIRVICREKPPVGGISVKEHFEVNIAPMHAQLTYRFFVKMMRYFFPGRNIDKEETNLDTSADDQQQQQQGPSFVDRIRGAVNHSFGKGKVKLAGGKGFSCSTTALDEIEKMKLRSEKNNAFRYIIIPAVPFIVSYKGNKDKNLEDLDRFNMTFPIFEYHNKNWTWLDLALAIKQRCKRVLLQQFISQKLLRNKTGAIERMTQVEPIDDEEKKRIILGNTANMLMEMEKKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVL3</accession>
    <name>A0A914GVL3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVL3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11597.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11597.t1"/>
        <property type="gene ID" value="Gr19_v10_g11597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11597.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39757" checksum="7F6284E1BC199137" modified="2023-02-22" version="1">MGEIKTFMDKMSEWERLSEKLRHPENPIVFFDIAAGGAPIGRITIELFGDVTPKTAENFRQLCTGELKKDGVPIGYKNSQFHRVIKDFMVQGGDFVNGDGTGMTSIYGPKFADENFEVKHSEPGILSMANAGPDTNGCQFFVTCNKCDFLDGKHVVFGRVLDGLLTVRKIENVPTRFCMQQLPSVDMDTPMHEEGEIVEQHESAGAEAVQHGGSAAVLQQHHSASVQYARPLVARPVTEQQIQALRTGSDVRPGSSLADFYKDLEQYQPTIPDSVALHYMRKNGIANPDVRVVRLFSLAAQKFISDICLDAMQQARIKGLGQVKKGQREAKYCLTNELLQPVLEEYGIQMDRPPFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVP0</accession>
    <name>A0A914GVP0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVP0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11766.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11766.t1"/>
        <property type="gene ID" value="Gr19_v10_g11766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11766.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14910" checksum="E6BAA69FC33D5710" modified="2023-02-22" version="1">MWLVLCAFVIPSVFCALLGLYLCIYHTHMASVTRDESVHLLYATKRQMPSPPLALMNFSLPIAPTSRRLCPLPPPSHFHSSWQLPSPILPPPAYSENEIWPMAFGDPVNSSPKAQHFINQPPKLCSIAMPNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW67</accession>
    <name>A0A914GW67_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g11329.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11329.t2"/>
        <property type="gene ID" value="Gr19_v10_g11329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:low voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:membrane depolarization during action potential"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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    </dbReference>
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        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
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        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF230">
        <property type="entry name" value="CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="12" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="139"/>
            <end position="156"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="1300"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWQ7</accession>
    <name>A0A914GWQ7_GLORO</name>
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        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914GWQ7"/>
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        <property type="protein sequence ID" value="Gr19_v10_g11875.t1"/>
        <property type="gene ID" value="Gr19_v10_g11875"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="9">
        <location>
            <begin position="221"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11875.t1"/>
        </source>
    </evidence>
    <sequence length="511" mass="56301" checksum="C8685997C30B678D" modified="2023-02-22" version="1">MKANIGTKVLAQQKVAADFPCPSTSASVGCEPNWRCSFCLGLLDDDELLEKIADEAAHQLRQEGHEAVNFVLALNVPMSVLLREAVVERLVEPAWSPMSMSPKELLSRQLMAKISKTTGLRPSLNSDLILTVTLENDEFVQADFDFLVLNFSHEFMRAPASKKRRMQCTDHAEMASSLLTKMKIKAARDQMGRAVANTFKLLPARRPCACVSVVFERQPLFIGGRYCKYSRMLPQSPWIGAVTDEEAAPTDVGIGIVPARLPPQNSVSEKIAGPLVRHFGADASRFVAAGREDIDVRMLGTGRPFAVQLLNVRKAACLRTHASAAATLAALCAQINAGERARDISVHALAHVTAKQAQQLNVGQEEKRKTYSALCCTRTPLADDAPLRRLQAHAFPLQVAQRTVVRVLKRRPLLDRMRCVYAMHAFALDAHHFVLRLQTQAGTYVKEFVHSDFGRTRPSVAELMGVQLGQVDIVQLDVLNVDLNWPPGEGEKGEQKTGTDGKEKQPTKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXH1</accession>
    <name>A0A914GXH1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXH1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11291.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11291.t2"/>
        <property type="gene ID" value="Gr19_v10_g11291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036882593" evidence="1">
        <location>
            <begin position="32"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11291.t2"/>
        </source>
    </evidence>
    <sequence length="353" mass="39780" checksum="65FA564DD488F5EE" modified="2023-02-22" version="1">MSFFVLFVESLALSVLLPLLFLHHRPSNATAEGQFALWSPPSVPTADLFFSPCTFPLIYPFGRGAQPKKEEEQLAHKRQHLRHPSRTGRVENDSLCHIHRHIPFICDLHRALIVTHRDALRLASVHRQHAAVLSDEASTSPNFVVLIVRQLAQPTSPLYVTRNSSEFGCLFRLPCETMNAETVQKFVRSTKVFMRLYASVLFNRWSQHRSASLGAAGLPQNGKKTFCRHPPMVLAIGLITNPRRITSVTLHTDNQRLLPFLVNVQFECTNMLLQDARGLPLSSFDIMWGSEFSFHSKGKPLIDVLSDLTNRAGHAIRDFYVTKGLVLFALVAEWMVCKIGWAADWSDPSCACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXK4</accession>
    <name>A0A914GXK4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXK4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11695.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11695.t1"/>
        <property type="gene ID" value="Gr19_v10_g11695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11695.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13601" checksum="6B2D6983B916CEB3" modified="2023-02-22" version="1">MMCLSSTRLVVNRWCSWPHLPFLLLMGGEWSKWNCCRNSSSNTRAQEKIKTKQKKNDRKTLSVVGEGDGNHGIKATILPLLSADKHGDTVTGLTYPTRWHQHLLPPQSFDTLREEEAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXW6</accession>
    <name>A0A914GXW6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXW6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12159.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12159.t1"/>
        <property type="gene ID" value="Gr19_v10_g12159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12159.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29986" checksum="16B4634E745BBA24" modified="2023-02-22" version="1">MVEIQEENSEQQQPTSAGAAGERQPQQSTPLDFIKRNQIDALCFVLRLATIYFSLNYALSVASPATQKMAFTKAFAAAAATNAFRLHHRMRGVDVPLFTQQFLAHLIREDSAHYLFYCLILIITSPVTIALLPIAMFALFHAIAFLTKCSNEMGWNSTLILKLAQLKAQHTPSILSTVACAEIFLFPLLVAMIFTGKANIFAPIAYYQFLAMRWMSLRNPYTRAVFSQLRVSILSVADHQRCPAPIRSLVHKLISLVERIGQAQLQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY50</accession>
    <name>A0A914GY50_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY50"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12224.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12224.t1"/>
        <property type="gene ID" value="Gr19_v10_g12224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12224.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23252" checksum="753723622EC4E951" modified="2023-02-22" version="1">MVVPIASSSASRSAFKHRLLIALICGSIRGAVVPGQQQPSDAALPADSQQIPDKMREVNAGIYPPSDEHLPEPNNGTDDATPEKPDRKCGQQPQDEWDEEEEEDELDKEDEDEEENGWKDRERRRRGGRMGRKRTTKKRRMNGKKEKEEEEEEEEEEEEEDEWEERERRRGGGRMGRKRKKKKRRINGKKEKEEEEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYG6</accession>
    <name>A0A914GYG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11556.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11556.t1"/>
        <property type="gene ID" value="Gr19_v10_g11556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11556.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="14954" checksum="A571D1FE94954626" modified="2023-02-22" version="1">MFISCKLFLIRKLDQQNGQLPEPVTQNECSGQSCKSSVGEQFDEAVPVASNNATTIDCSSPYCCNNELKQAMKDAYESAGVANSECSLRSETTTEEEQQQREGERCGGDEQKRGPELDEDYHLAEEGSGGDGTKNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYR9</accession>
    <name>A0A914GYR9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SAND domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYR9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12429.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12429.t1"/>
        <property type="gene ID" value="Gr19_v10_g12429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059099">
        <property type="entry name" value="GMEB1/2/Spe-44_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000770">
        <property type="entry name" value="SAND_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417">
        <property type="entry name" value="GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417:SF4">
        <property type="entry name" value="SAND DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25892">
        <property type="entry name" value="Spe-44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00258">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAND" evidence="8">
        <location>
            <begin position="132"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="711"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="733"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12429.t1"/>
        </source>
    </evidence>
    <sequence length="748" mass="79824" checksum="B5450DF36A4D7B06" modified="2023-02-22" version="1">MASSFLSKSPSSFANVAHRQSPLAHNADTEYEKPSSSTHSAAPAFDREEMLAANNEAAMALSSLIEFGQNQQQMHRDGVGIGDCHGFVGCPPSPILAVAAVTSPAGDATAAAGALSLQSHAPGAHNATIKSEENESSDELPPADELASDAPVHEIRCGLLNARLHMQRFTCPGIHRKCVEFEGKLISPRQFTIKAEKDKQKDWKGSIRLGKHNLRTLMEMKTIDFYEHATNCSLKCQSRNYIKNRKSEGVGGGSESAMAFDGTEEGKAPSNSGGFDFCEATEVHSTTSSTSTRKSSAVLEDYVSQTIPSVNGPFVPLNLGTFCLNGEENSAMVAANGDDKTIPMQHHSALIGMNGGGVSALCGGGRSSSHHQLINNSSSVPTTTSSPLSSAAFPPFSTSSTIAHSSPSFVPSFGLLQQSPLKQLFTAQNSHKQQQLGTALSSPPSTGGLLSSHGTQQNGIKTSTTIGGGQSVGVHPAELNQQENNGNSTNTLALLLQSLQTSILLEQQQKAAILNSNSTNNNGNLAAFLNRIPLLNGGGGGGTVQQGTMLNEQSLIGGNRQQQQPLTGIERLLNAAALLPQLNPFQQQQQRTQTTTTVKQEGNGGGGNVRKIMEENAGLFWSQMRSMGLLDDLLNTLSTTLERLKHIYVNGGNAVSEDFAARRLSGVALALDLCTLFSDKIHNRCIQATLETNLITKELLELQRKQEEQKRKLESAKRKSQMFELLKNGNGAREGESPPEMKKIHLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYS1</accession>
    <name>A0A914GYS1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYS1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12031.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12031.t1"/>
        <property type="gene ID" value="Gr19_v10_g12031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037161701" evidence="1">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12031.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16455" checksum="CF9D7FFAB78B19D0" modified="2023-02-22" version="1">MPILFVLIGAKIVIGGLDVEEWDFPSDRLEAFQKRKARELFGKRSSPPAAVPYERHSRRTRELFGKRADPFAESNDEPLMAVDFPEEDEHRIRMPRAVFARLRTVQNRPNDVEEEQEAPFSTEGLWLLQRPRRGVHRELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYY3</accession>
    <name>A0A914GYY3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12411.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12411.t1"/>
        <property type="gene ID" value="Gr19_v10_g12411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12411.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10243" checksum="72218B7ED2D936FA" modified="2023-02-22" version="1">MSHSTSEYNELDEPKPAQTSFFLWMNENREKFHEPGMTQADVAKAAGAEWRRMPESEKAKWGQKSAEDKERFAQELSEQRERQHEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0I9</accession>
    <name>A0A914H0I9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1282.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1282.t1"/>
        <property type="gene ID" value="Gr19_v10_g1282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14211">
        <property type="entry name" value="STKc_HIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000029">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="586"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="265"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="533"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1150"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1392"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1150"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1392"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1434"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1282.t1"/>
        </source>
    </evidence>
    <sequence length="1552" mass="167351" checksum="0113ADD282EB6FED" modified="2023-02-22" version="1">MDSTTKMPIVGSTVVVGGNEMPWREETNAEHCFEGAIPSHSSPSLQRHRPSLTFPPHFPSAFAQLNNATISIDDERKRRNRRERLPSFTQQQSQPLTEAVLLLFSNINRPTRTTPTTKSTPNPLIAANFFHFIPKRTQFSENGQKVHHPPPPSFGLFIVYNNNIIVSTEVLAVQVSAVIINSRIPYRHQRMQNSQEQQQQRHQQHHHQQQQKQRKRKFEAAADGEDFSARAESVATTKKIVAVEQPQLNPAAPTRTTRSSNRIANQYAHNPSPHPSPSAYQQQQTYGGFQRHQQQRGRGQRKSGGKNQQQIVGEAAEASAVGVKRRQTSATKQRPREGAFQQAEDPADTPPSLSLIASNSGGSTRRPAFIKIEEENSLTSAPSSLSAAATLSANSTHGRQQRVVAAPKAVAVANCCLRTRPPRTTRRHPSSNKSLRDIEISAAAGNGMFGGAILGPSAGGVFSVVGNSSATAALYHQQQQQHLTGNGATSTTNGGVGTFLVKNGGGAHHRAVPHHHNNSNNHHHNFVQPTTTALLKPMGGGQMQTSQQGQTKQQHQSGHHKSRQSTEGEYQLIKNEVLSSSYGNQYEVLEFLGKGTFGQVVKAWKKGTNEIVAIKILKKHPSYARQGQIEVSILSRLSNENAEEFNFVRAYECFQHKSHTCLVFEMLEQNLYDFLKQNKFTPLPLSSIRPIVQQVLTALLKLKQLELIHADLKPENIMLVDPVNQPFRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFREAIDMWSLGCVIAELFLGWPLYPGSSEYDQIRFIVQTQGLPPQQMLAEAAKTHRFFKMIKDMASYWRLKSMEEYELEMSTKSKETRRYVFNCLDDIAQVHIPTDLDDIDRMCERCDRQEFVDILKQMLSMDQDRRLTPAGGLQHKFVKMSHMIEMGRTKYCQMAAQRMEVCYRFGLATAASASANNTGAVAYGRASVTGGSAVAPGPSGGTAVAGGQAPPLMAAPLIAAAANAAAVAAAAQPPNQQRAAAVQPQAAAALALSAADFSHLFQHYQSAIGQLQPVVGSAAAAVAANQAAAQIAAVAAAAPYVCQPLTAAATVLPYGSNRHQPPPQFATVAAAASQAQSISQFVPTAAHQFVDPLLAAATGAANAAVAAAAHQQQQQNNPNCSGATGQSAGGTATVASHVPSAAGPSHGWPPHTVLQGTTNATAQNSAATLAHVAVSNANANTTAALFPWAIAAAAQQAALLPGGNNPAGAAVSDFFLPANAAAAAALQRQMATAAAALQFPHFFSAPVQAAAQQTAKNYSQQLQLLAQMQQQQQQLFMIQEEWAAQLLNGVRPLNAQQQQMLQQQQHQAMFARLKNEAAILMQNSLAEHYLLDRSNLEHQLKQQRRWCVVAERFRQQQRGSQQQQRQQQQNAVGAGGGTSSMSMSARKSSNARCAVVRPQQQQPSQQQQSYQQMLLQQQAEQQFLAAGGNSASGGGVGNPFEMATAAGLDSCYAPVALQAAAAAAAAANRSNVTAPNPAMLAHMLDLTNASLYAELGAGGGAGGSAASGAAYTNQHYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H299</accession>
    <name>A0A914H299_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZIP11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 39 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Zrt- and Irt-like protein 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H299"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13219.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13219.t2"/>
        <property type="gene ID" value="Gr19_v10_g13219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF211">
        <property type="entry name" value="ZINC TRANSPORTER ZIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13219.t2"/>
        </source>
    </evidence>
    <sequence length="349" mass="36937" checksum="8B6F854910DFFC01" modified="2023-02-22" version="1">MIPNWDPVLQALFASLFTWGVTALGAALVFVLPASSRVFLDSSLGFAGGVMTAASFWSLLAPAIEISENQMGKLAFVPVAVGFALGALFVHFSDCMIPSCVNAELTVISAISGECQGTNAPGVMNEMRIKKLGEDPAAQRMLRSERNCEENVEGGRHLQMDEGAEDANNTARSSELGSNPSASQLLSWRRILLLIMAVTVHNFPEGLAVGVAFGGVGKTPSATFEKAFNLAFGIGLQNFPEGLAVSLPLAGFGYSKWKAFLYGQMSGMVEPIAALLGASLVLMMEFALPYALSFAAGAMIYVVFDSIIPEAYSRGNGKMSSLFAILGFMGCVLALFLTDSILTLTFPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2C5</accession>
    <name>A0A914H2C5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2C5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12591.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12591.t1"/>
        <property type="gene ID" value="Gr19_v10_g12591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12591.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15361" checksum="00B40C87FCB1528F" modified="2023-02-22" version="1">MSNSSSSNSRRKRLLNTGNGADVHFLVGEGDEKELLPAHKALLGTASDVFEAMFRFDAQNAPAAAAAAGTVPSEVIEPVEVPDVEVGAFKAILAFIYADDLRALNGDNAIAVLYAAKKYDVAGLVKFLCELFHREAEQCFCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3Y0</accession>
    <name>A0A914H3Y0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3Y0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13765.t3">
        <property type="protein sequence ID" value="Gr19_v10_g13765.t3"/>
        <property type="gene ID" value="Gr19_v10_g13765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038137966" evidence="1">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13765.t3"/>
        </source>
    </evidence>
    <sequence length="227" mass="26527" checksum="18714509BFCD91C5" modified="2023-02-22" version="1">MTILAKILFSFYLNNFICQCAAVISSRARMFSSKKKVARTSKASTPLNKDDVERLRRIVLGDGESKIDDFASSKATIDGREEVVINRWHHFQFQNEETPRSVMLLCLRAGGSKQKKEEEWHKTEAKRCHQNCPQNGEHKSVIGRRWRKRQQFRQRKSRTNIGVLISRRILSIFSNTMLKTNEIRQIMVNDARNSPNSWTKWRRLLIIRLKRRRSAAFSLPIGGTKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4E4</accession>
    <name>A0A914H4E4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4E4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14050.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14050.t1"/>
        <property type="gene ID" value="Gr19_v10_g14050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037610012" evidence="1">
        <location>
            <begin position="27"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14050.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34644" checksum="EEEF1B76FF96F922" modified="2023-02-22" version="1">MIDFCLFYSAKVAVVFILMISSPTLGAQRNENDKFFDLMTAIGEHFGGEFNDAEKALELNLNGANSFLEELHKFATREIVKKVENGKFECKELEALVHGKHIDGTLKARQENPQDKIQTFLAVPKCFIFQETEELSSIFDYWIEIIEMKTKAIFGVVIYKKKYDKFKSENSKEKAFKLSRENYKILKELNDQKLSIYESTNLLRAAFNMGDKGIDPELHLDSQDKEIRKNVQKDVEESCKKFDNEEAKIIFLNNVHYELTINFVFNQRKDIYDRVEDLLSDWVGHRLLKKSIKKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5C8</accession>
    <name>A0A914H5C8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abnormal cell migration protein 18-like fibronectin type I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5C8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13973.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13973.t1"/>
        <property type="gene ID" value="Gr19_v10_g13973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13973.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13448" checksum="12682DFEED617966" modified="2023-02-22" version="1">MHNGVKYRNGDEWIFRRSFIMKCYADDTRWEANVAACLSPMGQRIPIGGKIQDQLGKWKCIQVIVFFSTLVYFLEKDEPNTTFTSIPAAFWWCLFSQTKWVPQTADKFLKKIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5R5</accession>
    <name>A0A914H5R5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5R5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14247.t3">
        <property type="protein sequence ID" value="Gr19_v10_g14247.t3"/>
        <property type="gene ID" value="Gr19_v10_g14247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14690">
        <property type="entry name" value="bZIP_CREB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000003">
        <property type="entry name" value="cAMP-responsive element modulator isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003102">
        <property type="entry name" value="CREB1-like_pKID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001630">
        <property type="entry name" value="Leuzip_CREB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879:SF3">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02173">
        <property type="entry name" value="pKID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50953">
        <property type="entry name" value="KID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="KID" evidence="9">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="307"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14247.t3"/>
        </source>
    </evidence>
    <sequence length="369" mass="41018" checksum="1C9F4545590F9604" modified="2023-02-22" version="1">MNSSMPANESLESTDGDESNSELRDPHSALGVEEVVNEEEARRRREQLNRRPSYRMILKDLETVGDKQLKKEMLEDGNTPNTYNHNHERNGRNTVHQLGSPDESAPFVNNNNNNIGGGGTAAATNQQQLTQHISPPTQQNLAALGQLNLIGNPAATAQQQQIRLMSAVTEMPSQPQPQQLPSTNSVSQQQQQPQPLLTAVNNLEMLGLKAPETLGAFGQNDWQNNLLSSYSRAPQQQQAPPQQQQQAPLMQQNNAGGPVGSVPSPLSMQQQQQQQHVTPPHGLGTRQGSASLTSFSPNVRSDNDDNSRKRQVRLLKNREAAKECRRKKKEYVKCLENRVAVLENQNKALIEELKTLKELYCRKEKGDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7T8</accession>
    <name>A0A914H7T8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7T8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14818.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14818.t1"/>
        <property type="gene ID" value="Gr19_v10_g14818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14818.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30427" checksum="6B85960891D32D3D" modified="2023-02-22" version="1">MDCFAEAEHGCVVKGEGTIHTTSAAREDSDELGMALATGCELIRDIKKDAQFEKAGLSIGQLGQVVADACAEQNAKGFEQHELRLIQTLATNEFDAYLNNELAHGPLKDGLNELLRAKEHLLPSDLLAFLLNKINTFGHNQEGIGGGKWPKHPPKSYCRPSSSSNNGDNDDSPPATDAPCGEAYAAFAFVITGLLARNMGMIVLGYWLFFCWWILGFLFVLLVLCIGVAIEQSQTYMLGYGSVYGYGYPYGGWYGKRQAGLAHLLEALVEMVALLVMPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7Z2</accession>
    <name>A0A914H7Z2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7Z2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1505.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1505.t1"/>
        <property type="gene ID" value="Gr19_v10_g1505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="882"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1505.t1"/>
        </source>
    </evidence>
    <sequence length="986" mass="108627" checksum="E1995CC7205E2CC4" modified="2023-02-22" version="1">MSECRNPAIHCTAIASRRIHFLWRKALNSIPFKMLLKPFRPTAVGYSLRKGTAPRRARTVPILLLLFFSLLGIILSEGRRNWRKREGEEGEQLTENGGGRRRLRRQSLPTNNVLVYASNSNVSVSDRVQVLSKESQIRMFEQNLNTTVWSNASLLQMSLNGDQIALSASQSIALVMTLGGGAQMQGTGDTLQLNESSVSALATQSGDVVHSRLEAELTGQHVNLSWADLASRTIAFRALDARMAAVVATGWSRENAGEEVRVLSAPAEEGRQRELSVVANSPEYQVQIRLIGAESALLFHDAHLQIPPDHRSLLLNALDWRVNVRSALSPFELHATESRLQLNCFEEALSLELLPHAMELHVRQFSSFLVVQSPSMPGKLRVNGATMNASTPNSLLRMEMFSQELRLSLSRKGKESVHSQQKGSDGDQSVLIDAVNSHLRLSHSNHPTVSLTAAKHFVEMLGGRPLLRISTGNVSVEMELRDERQTVVDLDTDIVPKELMGNESVENSFGIGPFASRPTVPIPPVLEKNRSTQLTSASILSTSSPLPSIVFPASNLSGTTFLPATPQMADPFELFTFQHTFPTSSAMSTTAPSLATSGKKMNDSIPEFPSPESELFTFPPSHPPDADFLVGQFETVPAEIQPGTTWSLFPISATISALQFPEGGNEQQRVAEQFPGIRRENLLIWRPEQVMGTDEGDTNGKLDTYLVEEEEKRPRRTLTDDGRRAELEVDIAVEGEEDVRAERLRRELGEGIERMLDERWGQMITTRIEEGTVQPEEKGKDDMEEYKKIMGTDEEMAGKEGMDDEKRMRLKLRVTGVQLEHLGQTDGVKEVVRMHFTLEGSRTELMKALRRVERMDRKLTEQALLHEVLSKPRLTSDSFDFSSSSSSSSSVSSSSSSSSSSSSSSSSSSSSSSSSSTLSAISAHSLPVLLVGSLCLIAALLSMLIVLRPSARAISKIMRWIQRKNESELKVRRIGGKMGGGGILPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8J3</accession>
    <name>A0A914H8J3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8J3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15196.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15196.t1"/>
        <property type="gene ID" value="Gr19_v10_g15196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15196.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27574" checksum="E5A0DEE91983DD3E" modified="2023-02-22" version="1">MCTPRHIYAVRHAERIDDTEKRKVWHYNSRFSKDNPPLSPRGRQQTEELYTEFLNIPIEYCFTSPYERCVQTAAKILEGRRTLINVEPGLIESLQMIYDRSSVRKVGFHTGKELAQRYDNINREYEPMFLAPPESEIAKGKHGCTQRVEKTLRKIVDKCNGDILIVSHQGPLAALQKLLTASIEYGGTATVSKYAEVPGCIGRFEAEYLYDSSHLSDPAKLCGKDYNRKKKRKMSQILID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9W0</accession>
    <name>A0A914H9W0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATPase protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H9W0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15142.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15142.t1"/>
        <property type="gene ID" value="Gr19_v10_g15142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000003">
        <property type="entry name" value="Atp synthase f complex subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="15">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15142.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11196" checksum="CCDDDB078F2A457A" modified="2023-02-22" version="1">MALLLLARQRGSRFLPLLTNSHNAFSTTNVCKDIDSAAKYVGAGAATVGVAGSGAGIGNVFGSLVIGYARNPSLKQQLFQYAILGFALSEAMGLFCLTMGFLILFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAP4</accession>
    <name>A0A914HAP4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAP4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15338.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15338.t1"/>
        <property type="gene ID" value="Gr19_v10_g15338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15338.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11713" checksum="A973552DD3171DD9" modified="2023-02-22" version="1">MRGHKLLSADCVTEEAQKLQICIARIENSHRTEVGAVPQKKTEPYRLPCPLCEGYGGKCQNNDSLWVCDDWGQTLAFIKVENVPMTHFYCGCGATPVEEFPTIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB59</accession>
    <name>A0A914HB59_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB59"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15479.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15479.t1"/>
        <property type="gene ID" value="Gr19_v10_g15479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15479.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38004" checksum="E3B348211B43BBFB" modified="2023-02-22" version="1">MSDNPNEAQKQLKAISISNDVLFDVFKFCGPLLLGLKVALISRRFDLLVDAHFKSNKWSLDFLDIRRAIKGNGAEIVKLIGLCFELRLSIAQQALPGNVVEFKGLAISYMDRSVVEFLKLMRPLFNSTETILYIFTRYDQTRSWEIIWHRIWPLINDTICGFYLYSSELERLRQFSPTVLRNCPKLRVIRSRGLFPEFPANDSAGASTDQAVAKWLHTPRADGLPKVLGCRFYLEGMEGLKMAFASSVDRANFIICFRFWSSNVPFELKNNLTGERLELRHFDEGNWLLVRCPIERDEDKWAKWENEAAENTYRDIGDGLFDGNGGPMSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBA7</accession>
    <name>A0A914HBA7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBA7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15006.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15006.t1"/>
        <property type="gene ID" value="Gr19_v10_g15006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15006.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8868" checksum="E085926F6CEF2937" modified="2023-02-22" version="1">MSITKSTDRTAKLDKLNPIQLISLDKLNPIQLISLDKLNPIQLIRILLSQSLITLIMPIQAKILLKMSESVKLSKDSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCL9</accession>
    <name>A0A914HCL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 144</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15876.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15876.t1"/>
        <property type="gene ID" value="Gr19_v10_g15876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15876.t1"/>
        </source>
    </evidence>
    <sequence length="378" mass="40326" checksum="8726E9832F240A60" modified="2023-02-22" version="1">MSVVLGLSACVVSSFCFGTMYVAVRRAGDPGDGMVVQWLVCSAIFLIGLLTYIFTGTPPFQHFAMFGGALWAVGNLTAIPIINAIGLGMGILIWGVCGCVVGWAIGRFGLFGLKESVPSSPNLNYAGLVFVIIGGILFALVRPKGKNDVQTVVDSASSELSRQAIPLTESAATGRGTVEERIGLVEMDGGGAERTAVAVDVVVRPRKSSGGAAVTSTNGLRGRVIGVVFSVFAGVCYGSMFTPVIYMQHNPQKFNNPPREAIHYVFSHFSGVYLTSTAVLLFYIGYKNNKPYIDSRLIFPSFLAGTFWAFAMLAWFMANDLLSQAITFPINSMAPGVIASLWSVFYFGEVDKKDLKLLTAAIFITIFGAILVGLSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD28</accession>
    <name>A0A914HD28_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD28"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16244.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16244.t1"/>
        <property type="gene ID" value="Gr19_v10_g16244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16244.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9292" checksum="7FA8437992CB7A67" modified="2023-02-22" version="1">MKMISRGMSVFKSSFVKSCCQMAMKMRLFSRDLRVLSTFITAHQARIISFMFPCFGKASASYLKDIVIPPQRTCFLDIPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEA2</accession>
    <name>A0A914HEA2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">T-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEA2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15820.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15820.t2"/>
        <property type="gene ID" value="Gr19_v10_g15820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000010">
        <property type="entry name" value="T-box transcription factor TBX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF181">
        <property type="entry name" value="OPTOMOTOR-BLIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="9">
        <location>
            <begin position="198"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="615"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15820.t2"/>
        </source>
    </evidence>
    <sequence length="661" mass="71883" checksum="BF39E6DE25430607" modified="2023-02-22" version="1">MDSPLLLAPFRKFLPLSSTFRQMANDPRLLEGSSPSNLCHLPVKDEQRLNNGASTSATAPATHPPFDPPTTCAASGSSSSSSSSSANSSASLCPLRPSSSAPCPSAFLAQMAAFSGLRPDLFGPLFGAASSSSSLPPGNFVPSSGVLPPLPLRHPPPGPFDLGAALHASQNPMAALQNPPFRLCLVDDGITDEPKVDLEERDLWERFHRLVNEMIITKSGRRIFPAIKANLSGLNKKANYYVILDIAPCDPSRWKFHNSRWTVAGKADPEGPKPLHIHPDSPATGEHWMSKGANFNRIKVTNNMTNRNEFTVLNSMHKYQPRIHIVRSNDIHSLKVANWTTVIFRETQFIAVTAYQNNLVTDMKIDHNPFAKGFRDSGAGKREKKRQLTSHHHHHSLHHSHPSNSASVARAIFEGDLEESEDSETEGGGSGGPSRAKRPKSEQSSSSASLSPAVASRNGAEERRKMSNVNNDSERARHAHVRPPQPPQNGVGPPPLQPAHQQHHPFAHPSSSGLPHPLASAAPPPLPRLFHHPSMIFPAAPLHPLPHLLPPNNNTSNPSDFVIPPPPVPSAAAFLPSVPSLLSAHPQPPLPPHPSLFAMHQFLLLQQHYQQQQRQQLQAQTLLKGKKEEGEAKTEEKTKGTKRKAQFDVNSLLGRGEEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEH1</accession>
    <name>A0A914HEH1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEH1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16608.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16608.t1"/>
        <property type="gene ID" value="Gr19_v10_g16608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16608.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20632" checksum="D0350C8FB0895CE3" modified="2023-02-22" version="1">MLTGSDLDFFNLCFKLAETAYKAQEVPVGCVIVTNEVVIGTGFNQVNRTKNPTRHAEFVAIAEANEWCTLHNENFIETMKRATFYVNLEPCIMCASALYQLRIKRLIFGAKNPRFGGIYSVVSNADFGHDHEIEITSEIEKDRCISLLRTFYDRENTFAPEEKRKSKKKFQIELVCRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HER9</accession>
    <name>A0A914HER9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tyrosyl-DNA phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HER9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16844.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16844.t1"/>
        <property type="gene ID" value="Gr19_v10_g16844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16844.t1"/>
        </source>
    </evidence>
    <sequence length="509" mass="55900" checksum="D893CFDA94C2B9BF" modified="2023-02-22" version="1">MKRQFVEGKCVHNGNTPSTAPEGKMSKSGDVGVQNTLAEPNSSDLMDGGVHLVKVECLGTEANNGKGNVPRALSLFELIRAIRPIASIHFNYCIDPQWVLRQYSRRLRECPIAFVVGHQQLQALRSAVPSAFAASVRCAGVPMPFAYGTHHAKLSLFEANDRALHVVISTANLVEEDWTAKTQAFYHARGKLDTDDVERGAGTASTSVADDADATTSSAPLQRFRDDLVAYLRAAYPAGAGEVHQIVQFWVDRIGQADFSHIPDRIVASVPGRYQKSPAGAMCRFGHLRLRQLLSEAFSAEERGRHHKTFVGQFSSIGSLGARAEAWLCDEFLTSLSGGKSMLSASALKLIYPTVENVRDSLEGYAAGLSLPYSSQTHRKQPYLKQFLHQWKCERFKRHAASPHVKSYVALDSAGQCQWLLLTSANLSHSAWGKLEKGGTQMFVRSFELGVLMCAKDHQRRALFPPFDLPLTKYAADDEPFLVDMLYTTKPTDANGFRGAMDARAALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG33</accession>
    <name>A0A914HG33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HG33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16298.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16298.t1"/>
        <property type="gene ID" value="Gr19_v10_g16298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000224">
        <property type="entry name" value="serine/threonine-protein kinase mph1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="118"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16298.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46170" checksum="66B7C8DA6B66AAE1" modified="2023-02-22" version="1">MELVKERLQKLKGHATERSKFLSGSVDLDKAPSTSTKTIKDFDGLKDSNLADLEQSKNAFARCCLCPLCFLSSTTAKQSRAIRKEKAPHDRGRNNSVQLPIPNRSMSGHALIVNGKGYSVLSTLGKGGSSVVYQAFSECHKRCVAIKCVDLSSADATLQDSPNVIRVFDFEKRKNKMFVVMECGDIDLATFMHKRSKEIDAKFVKYHWQEMLKCVKVIHDKNIVHSDLKPANFLFVGASLKLIDFGIASNIPSNKTSVMKEIQVGTLSYMSPEAIIGSYIDNNGVTIYKVPLKSDVWSLGCILYAMVYGRTPFQHLTNQMAKITAISSERHTIEFPKLHDHFLLDVLKKCLVREFRNRATIDELLAHQYMKDSLLATPSPRVPLPGKRFPLASIINGTEVEQKKGSLMRGKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGK0</accession>
    <name>A0A914HGK0_GLORO</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGK0"/>
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        <property type="protein sequence ID" value="Gr19_v10_g17168.t1"/>
        <property type="gene ID" value="Gr19_v10_g17168"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17168.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="18107" checksum="BFE6DBFA5A2036ED" modified="2023-02-22" version="1">MDTSKENTPPRSQRPQCLHLQPKKATVAEMFELTAQLRQSEETRDEQIKEEHRLRNEVLELVPRVMTKYLDSRFERLKNAKLEFLRTSDSDRNSEAEELEKTKESVRRLKLKAAEEEEQQKKELEESKQHEMELERRVSRKLEILKALEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGL1</accession>
    <name>A0A914HGL1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
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            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGL1"/>
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        <property type="gene ID" value="Gr19_v10_g16428"/>
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            <end position="243"/>
        </location>
    </feature>
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            <begin position="33"/>
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    </feature>
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            <end position="122"/>
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    </feature>
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            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
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            <begin position="188"/>
            <end position="206"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16428.t1"/>
        </source>
    </evidence>
    <sequence length="792" mass="83917" checksum="CF230B4332D41635" modified="2023-02-22" version="1">MSTMNFSAFLSKEEKELDQAYDKLKQIREQINKRKGVKMESSKIVKGDATKAQTFQEGVTRAEEVRKAAADGILRPQSSKRKKNEDADNGHSEDTVQSEPQGEHSEAPSGEQSHTNAQNSPDQMDDAGNSEKNSTSVGPVGLFNMNFRIPKKKPRVEAQESVSTFSNAMPDSSETFSGVKTWDKSPDNVFSNTDGFGQSGRRSSVASPEANDSFGNSGFGNSGFGSDDSKLDGNSRWGGGAGEKVDAAEAEAVVVLDVRTGTMKEAAYRATTFRVEEGSASRTVVRQLQVRIPATLPEMMASPTPVSEIPDLETTLRNRTATVVGVVVAAVVKVVGAEAIGGMTAEKVDEEEAEAVVVLDVRTGTMKEAAYRATTFRVEEGLEATLPEMMASPTPVSEIPVSEMTIRTRTATVVGVVKVVGAEAIGGMTAEKVDEEEAEAVAVLDVRTGTMKEAAVAVLDVRAGTMKEAACRATTFRVEEGLEATLPEMMASPTPVSEIPALVTIRNRTATVVGVVVPVVKVVGAEAIGGMTAEKVDEAEAEAVVVLDVRAGTMKAVYRGTTFRVEEGLEATLPEMMASPTPVSEIPDLETTLRNRTATVVGVVVAAVVKVVGAEAIGGMTAEKVDEEEAEAVVVLDVRTGTMKEAAVAVLDVRTGTMKEAAVAVLDVRAGTMKAVYRGTTFRVEEGLEATLPEMMASPTPVSEIPASETTIRTRTATVVGVVKVVGAEAIGGMTAEKVDEEEAEAVAVSDVRTGAMEAADLQSNDFLVEADEMLTINRIKKMFNGIVSKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHU1</accession>
    <name>A0A914HHU1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
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            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHU1"/>
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        <property type="protein sequence ID" value="Gr19_v10_g17072.t1"/>
        <property type="gene ID" value="Gr19_v10_g17072"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
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        </location>
    </feature>
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            <begin position="281"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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            <begin position="545"/>
            <end position="612"/>
        </location>
    </feature>
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        <location>
            <begin position="649"/>
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        </location>
    </feature>
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        <location>
            <begin position="758"/>
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        </location>
    </feature>
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        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
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        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
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        <location>
            <begin position="923"/>
            <end position="950"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
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        </location>
    </feature>
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        <location>
            <begin position="328"/>
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        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
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        <location>
            <begin position="556"/>
            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="652"/>
            <end position="690"/>
        </location>
    </feature>
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        <location>
            <begin position="775"/>
            <end position="791"/>
        </location>
    </feature>
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        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17072.t1"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110346" checksum="BEF88B33C41A6CF0" modified="2023-02-22" version="1">MVSIRSPQKLPGENGLHARDGSLTKRKQEQWERERAEGEQTSGWFNKFGQKHTPGRRRAVNWAINEGAEAAEAEQAAGADNDKRRNESDGATTSSDQQLLNDNNNGTIHYQMQQWKNIEPSPMAHAPSPLVHHRPPSSIPPAAMLYSAPTGGFPVQTPMHFFTTPPPPAAPMQLFGDYHHQAQCQRQFLPGAMPMFPQFVPPPPLPSVGVIDTAAFILAAHQQQKFPMGMSQHPLMPTPPFSCPSSLEEAGNNSPAVEQHQQYQQHQLQLNETVPSTVLSSSPACIEADNNKATPRTAAKRGEAEPANSMRTPRRSLSMDASGTWEEELARQVAERQMSADREAQRALEEERVREREERECRAREEAEREAEERRRTDRIEARDQNERSTLASLQRAQREAELLRRAKLFRHILLDGDGQTDMDTARRLLKCADGEENVLNDVIRQLRDFDRQKRLANESCGSLSPSSTTGKITPKSAKDAGKAIGKTALFSRANSWNVKHSRTMPAAVFSPPIIAQSKMPPLSVVEHAKVRAEIVVTAPNIGHQKNVAFPPKKTASANGQNTVSTTASPSSQNKSTVTSPNASSNYGNGSQKSTPPDKQHKSLRQKVQNAVRSGAAMLRRKDSGGKTNGDGAKVLRTVGLFEQVTLRHRTSSNSNSSNNNQQQQQQQNRHPSSPSPSPTSGASTNSNTPPNQPAQQHPVEEQPLFSSPTFEFLLPPRLPVLADHRRRGRQPFELESMTLSTIASPEAANDVKQMNLKHQQQQHVVRGRHGKVDELEEEKEFDENGVEDDGEGRVAKCKNAQENCGGKAQQNSPPGSSATSSSSASVLRFRAALDSPFGSREDISNSLIVSNGYAAIPPAPPKIVGGPLRYANGVSVAAAHQLVPPSPFRRPAQNGGGGDSSEPLLRRSLRSPTMRRLQESLQSLAEDAPTSPTVSARGDVSRADTPKPFNCRTSQYRSLNLKRDTERQKQILEHLAQVRIQLKNSQVQIEQTISKQNLTTEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIZ3</accession>
    <name>A0A914HIZ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17071.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17071.t1"/>
        <property type="gene ID" value="Gr19_v10_g17071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17071.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11762" checksum="3AF3C8FA598F1B82" modified="2023-02-22" version="1">MGILKILWKLIAILPFLFFFSKPIFGECLSQLPRGHLASKHRPRARPIVRFLFGIDPQQLCWPTSTFVTFRGNGGDCEDGQTTITPQGDERWAKSLQFGVIALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJQ8</accession>
    <name>A0A914HJQ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g195.t1">
        <property type="protein sequence ID" value="Gr19_v10_g195.t1"/>
        <property type="gene ID" value="Gr19_v10_g195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF110">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="241"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="399"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="873"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1011"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1636"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1695"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1804"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1017"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1048"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1092"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1118"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1205"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1636"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1725"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1811"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1847"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1883"/>
            <end position="1893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g195.t1"/>
        </source>
    </evidence>
    <sequence length="1893" mass="209964" checksum="EC3C39A013D6ACA9" modified="2023-02-22" version="1">MLKMTPKGSVGSYKFSRSTVELETNINPNSLGVNAVAVVATTAAVGNGKMSQGMPAEVLPNLRDDEFHLHNLLENVDQGSDRDTSWRKYARLVLPHIGLVVFVCLYAMFGAWVFYSIESPHEDRLKVLGIRRVYKLRQALTGHLMMTRRSGEQRGRWMATMEEQLNSFSEDLFKSYKEQYVRYENVRLSHHLHSPQQQQQQQQQQQQQQQQQQQQQQQHNQPPQMDPRFRRHFSKSRSDGKLWTPSSSLFFAATTMATIGYGNIVPVTSHGRIACIIFALFGAPLTIITIGDLGKFLSECTIWLYRRLKDKFYYFRYNFTIFWLARRKKRRRQQFKKSFLHEMDAGGDFEEEFGDDDDAAEAEAERRARQQLQRLKTKSVDDWDEQENTEVPVLLVFAILLLYIAAGGVLFAIMESWTYMDAFYYCFVSLTTIGFGDLVPDRHEYIVLMLIYLGVGLAVTTMCIDLVGIQYIQKIHYFGRKFKGTDILQILRRKRMLERRFAMGEGKELIEYVIKQEREALFPSHQPRGMAQPVFHLASQAHSRDQPEEEKISLKSEQEMASAEEARVQDVLPMKDLALARAMDIPRILEPSTPVERKLSSPTIETPSSESERLIMYSFQRHKGRADSWAESGPTPSLQSSTPSTAPSVRQRELLYEQFRSPQPSITSFAFTFTPAAPPSPDLRQIAEAARSARRQASCPLLLSASVSASAPPRRKWHTLACPSHALAEVLRFARLCVVIVPFFESLSRKISSPRVPRGQLGKLSGSALGQLGQEGTVAESLLNNDNAEAEQNHQKQQQQHALELIHHEATFEHCTAFLRPEVFQAAPPKAPSSLQRFQCQPVWYYRRRRSLMIAEAHATAAADAHQQDNASMSGQQTLSAAPAELHQPILKRKRRERQARRYDPLQRMDWLALSPRIAITEEGVPVASEELDELMRSKDIPLLLTEHPAYRLLNNQPGGSSFSFDLAPSGSSTAREGLPKSMEHIAAAAAAALCCRSSTSRQGSVVEKLFPNGRRRRDESKTARKWKDMALRTRFRPDLGAEIAGRTATSTSKRQSVSSTTTTKGALTMASQQLVPRSSSSTKSKFEAVKRTTTPAKTISSSSTSNKFAGEKRPPITTSEKTTASSTPTTGSTPNKKITSSSSTKSNIEGQGRTTTSSKATSSSSTTSTISSNNRAEVETTAKQQQRGRPPPMALARAAELPQRPMPPRPPPSPSPPPPEPTPVPEIPMPKMAEQLELLVEDPRPSEPTLPPISRAAVMLEQIGELAADASVQSKVEQRFAPSEIVSELLGVCGSELRHLSPEQFVMEQQHLLMSDTLQASISENAAAESAAGSIAETQKLFHLASIEQPSPIVGAIQQTLAESPMFSELEKMSEPNELEEFSEMLEAGEEGGSEQSVFDIDLGAFELVDSGITAEELLTNEDPVIYHKDLPVHSVHHDTVQTEAAIENLMNATPSMLSTQVPPTMVADNYCFAVDGDRIQMADILGDDQWWKHTSRPTKYFYSKDLRRFYRVQCLAVRGRIISARLANTTPAMGGGGTGDAMAPEMQLAIAAAALPGGGTSDSFSMPLAFRRSMTFAGGARASLASAQPASSESAASGLSALQTSPNAMSVCPRGGFPPGPSPRASFAAFVHQLQHGGSQQQQQPQRSRFGPDAQRGETVDLADVYRVVRFYSFWRTCTSFHRIVTMIERVGHSPAADQRRSPSRTRGTGGTESYMHHQQLHPAASTSSATASESPSSSIARGDSLGRSPRGPPDFQKRLFVQYLWRNAKPSDKARVQREFDPRRQRLLKYVTDTAARKRMTSAKVQFRSGSAGTSTDKTTKWSHQTPPGSATVPFSTPSIRWRLPPGASASAGAPSPNLSPTHTGRRRPHSAGTALLRRTRTDAEMCPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK35</accession>
    <name>A0A914HK35_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK35"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1852.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1852.t2"/>
        <property type="gene ID" value="Gr19_v10_g1852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1852.t2"/>
        </source>
    </evidence>
    <sequence length="502" mass="58152" checksum="3576A05B665F5BA2" modified="2023-02-22" version="1">MHSQRINAEQSRTGATPARRCRHGQQLDMDKSGNNNPTELGPSSAFNSSNIQLEPPNTMVCARKLLDGCVRDRCCQVALDADVYFRTTHKYFKAFTKCKEEKEHSDAKLLQNKQLLVGLGEKLKLLQAMFGHDEQKKEALLAENVLLVADKVELQGQLHEQQALSVRLQVEIDRLRTSTEQKEVNSNEEHGDQEKEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEDEEATDKEKKESTDEEEEKEESTDEEKEESTDEEEKEEELMEKNLRTQGKKFKCTECAYRSAHSGNLKLHMRTRDGQNFGSEISDSGKFRVFGRFGFRVSEFEQNFGFCTPKNGIFETWKSLVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK49</accession>
    <name>A0A914HK49_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HK49"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17359.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17359.t1"/>
        <property type="gene ID" value="Gr19_v10_g17359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000138">
        <property type="entry name" value="Homeobox protein prophet of Pit-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF577">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="176"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17359.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="43346" checksum="02B7687F1875EED0" modified="2023-02-22" version="1">MSLANQNHSGAGSASSQSTAEMSSSSQTHDHTEQSLQSLQQLNICGAHNLPHQLTSESAAAHLSSLSAAATLSALIPDPAGMLSAVGIQQELKPATLPDFSHYNHYASATNIKPIIDGHNVLSAATVMGQSTNGQTLAAAHQQSSLKRIKAEPRPTPSVGTANIFSHSSYPSAPARRRHRTTFSQEQLAELDNAFTKSHYPDIYIREELAKLTKLNEARIQVWFQNRRAKYRKQEKQMNKAASSAAVVGGPAGLGPMLAQAQAQAASHMIQQQISAGGVQNGGGRTALGAESGGGMAGGYGTAGAGSGSGRGTTATTGVGSAVGLENYWCSSYQMPTSMSRPPMAMHYGGMNYGMGFGQMIASSQLNCFSTEAAGDIYNFYNKQQQTSGATSATIAAIQQTSAAATNSQQQQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKK1</accession>
    <name>A0A914HKK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g233.t1">
        <property type="protein sequence ID" value="Gr19_v10_g233.t1"/>
        <property type="gene ID" value="Gr19_v10_g233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g233.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="16820" checksum="EB2561E31B98B8E1" modified="2023-02-22" version="1">MSNNGAAQNAQPEQKEEAPAAQIEQPQAEKTASPTKLKPMIAAEVDAGTGEESRDSVQSAGQESAEADEDEEAGDEEETDEEHPPQQAEEKSNGHVAKNGHQQPQEADTAVETAEFVNEEPKARKRTGEGADDAEDASSQKKQRVEGVQAAEPEVTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL90</accession>
    <name>A0A914HL90_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL90"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2364.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2364.t1"/>
        <property type="gene ID" value="Gr19_v10_g2364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2364.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23612" checksum="1677FFD51BEC7052" modified="2023-02-22" version="1">MAINMSDKRGLMQQILGEADICVTSTGITISGPRLSNPRTIPFEESGKCRSCKSTEVELDTMITKEGVTIWCSRIKNTQFVPFDVIYDLPGHCFFRVKNKARVFNVPYGDPNPGTCDSQETETEQQDLKRKAKVALDLVEAGLMADAMQDGSRWKKAKTAINLLGNLLLADTLPSPPTLPVPPPIEPQQKQADEEEAKLQEFYDRLAATTSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLE7</accession>
    <name>A0A914HLE7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLE7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1862.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1862.t1"/>
        <property type="gene ID" value="Gr19_v10_g1862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1862.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17367" checksum="05333C06BBAC1EBF" modified="2023-02-22" version="1">MIESRRLFPAFPADDGVGASSTKALAKWLHTPRGDGLPKVLECFFHSERMEALKMEFVNSIDPVNFIIRLWHCPSDGIVPFELKNNLTGERLMFRRFDENFWLLVRCPNERDEDKWAKWEKEAVGWEWRHQWNRIIIDFEDSDIGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLV3</accession>
    <name>A0A914HLV3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2542.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2542.t2"/>
        <property type="gene ID" value="Gr19_v10_g2542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="10">
        <location>
            <begin position="15"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="546"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2542.t2"/>
        </source>
    </evidence>
    <sequence length="635" mass="73476" checksum="DCDC7911BFA51D7C" modified="2023-02-22" version="1">MGRMLEWLTEHGKPLRVKVTTMDADLNELSLERDSVGQHLFDTVCKIIGLREIWYFGLCFTNRKGFTCWLQMDKRIRDQSVPKQPDGSLHFLFLVKFFPESVKGELIQDLTRHLFFLQIRQSILTMDLYCPSEAAILLASYAVQALYGDQGQHQQQQQAEQLDLAKLLPVSVLQQYELTADMWEEKIRSWWANNSGLSKEEAEEEFLCVAEELDMYGTQYYPIRNQKDAELLLGVSALGVGIFETDNKLSPRPFFPWTEIKCISFKHKMFTIYTADKSKIKFRAQDMSINQSLLDLCVGTHNLYLRRRQPDLLEVQQMKLQADEQRRRRMEEQTRLHREREQRAQAEQERDRYRVELNHLSEQLSAMQSVIKSAEETQVLIAERARLSEQEAIEQARRASEAEAEAQRAKLSQLRAEETKMVLERKMREAEMVAQKLALQQQQKQQQQQQQQNNTNGISAVTVGQQQMPQPPPYQEAVESRQQQQPMVVNGGAMPSNRPTTAQSPKNGMASNNLIISTQSQQVQQLYTGSQYELATTMPESRTSIAAELQHIYAELEMSRSEYNERNHSLRERLVNFRAELELLKREGTDTENDRLFAQKMIAGHGFDKFSTLRKSIIGSPKSRVKVFDELAPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNK2</accession>
    <name>A0A914HNK2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid 2-hydroxylase</fullName>
            <ecNumber evidence="14">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A914HNK2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2797.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2797.t1"/>
        <property type="gene ID" value="Gr19_v10_g2797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="16" id="KW-0349">Heme</keyword>
    <keyword evidence="14 16" id="KW-0408">Iron</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2797.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36977" checksum="0C2327250BC10011" modified="2023-02-22" version="1">MNREETEKHPLIVTYAGRHYDISGFSKRHPGGERVLRMVAGANVDSFIDGTSELLGLRHKHSKAAYEILARYSLDQEFKRDPLVDNKAPMLWRVGELRERYWTWIHHPYDGVLRLFESELLERLTRTKWWVIPLLWLPVVSVFFFSGLPILREDFGPFGGTFLGFALFCAGSLAWTLLEYSLHRGLFHWHPNPQSYRQITLHFLLHGLHHKTPMDSDRLVFPPAAALLIVCFFYAIYRILLPFPFFCCFASGKLFGYIVYDITHYYLHHGRPEPNSRWHYRKVYHHNHHFKDSDSSFGISTTFWDCVFGTLGVGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNZ6</accession>
    <name>A0A914HNZ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNZ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2355.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2355.t1"/>
        <property type="gene ID" value="Gr19_v10_g2355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2355.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="39252" checksum="FAC45B083C3DCED3" modified="2023-02-22" version="1">MSILTESINGEITADQELLWLTCANLEPSEEFGKEVVDANSLGNRNKIEDMVLELKEVKEELKNTKEENKELHAKLAHQKQLNACKCMTVGEMIDMQKLKQQQNQTKENIGNIPDFKTMEAKVALEYQKLVEDHKALHIKMEEYQNKQQQNQKEINDKIGWLNEDQQKLVSIDQFSQVQTAISDIKQKQKNDQEELIRLKSLQSMVVSELGQQNMELQIYKRDEKLNNFLGQFIEEQNKNKKQMDELGNNSKKELEKYQKQQQLNIHVKMKQYQKQQQLNIHVKMEQYQKQQQQTIVDLQQTIAVLNDKINGKEAHASNNSTTNHRLRMLMSITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ70</accession>
    <name>A0A914HQ70_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FIP-RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ70"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g322.t1">
        <property type="protein sequence ID" value="Gr19_v10_g322.t1"/>
        <property type="gene ID" value="Gr19_v10_g322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057316">
        <property type="entry name" value="Rab11-FIP3/4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051977">
        <property type="entry name" value="Rab11-interacting_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726:SF7">
        <property type="entry name" value="NUCLEAR FALLOUT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726">
        <property type="entry name" value="RAB11-FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25450">
        <property type="entry name" value="Rab11-FIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab11-FIP3/4" evidence="3">
        <location>
            <begin position="88"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g322.t1"/>
        </source>
    </evidence>
    <sequence length="465" mass="53472" checksum="A7C5920987A2DF5F" modified="2023-02-22" version="1">MDYLEAEPSPSLSNGTLPSSSSSVASRLYLNGRLNSRRNSFNSEPELMQFNDRDSISTDFGNATNQMSILAQKLNELQEEKMMVNEEKSRLRTDNAILQERVHLLEEHLHATEQRWTEKYDEERAKSRELAHRMERERQLEAERESLKHQMLSNEVAQSEREKDRMAGELKEARGRLEKLQEQLVEAQQEAEKEQTEHRQLRREFDSYRREMSNRLEDNSVFLEELARQADELRQSGLDSVPRQGSLTDKIIQLEEEVERLSMDNRELQEQCTDLQAQLLHNSVECGKNLLADAGQPSLAAELSGTGMDHRRMLDIIKEQDIDNQKLRNYINGILMRQLAGDVVYERRPAEDLERRATSQPVSPSSSSVFARNALERFSLRQPTSSCHRQTASPTPQQQQQQSNFVSRLYNSIWSPQWALFRRKEETSAEGNGADNAEIGRVPEDPTPSAGESDVNKSKDQTPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ71</accession>
    <name>A0A914HQ71_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQ71"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3636.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3636.t1"/>
        <property type="gene ID" value="Gr19_v10_g3636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3636.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25817" checksum="2CB8D547C1EDC260" modified="2023-02-22" version="1">MFQDLLYVLDSFYGNRLPLIIGAVLYPIYSKFPNWMFVMFFFIAGHTFLANYLVTAFILLNRLTAIIMPIKHEKIWQKFLPFITIFVYFVPTLVYWPTFKMDAILIMNDPNSTTDRSFFVYAAGNLNSFTDSGNTKTVKILYIYYPLLMDTGTVVLSSWLLLWASSIFRQQLIKDFTIIRIRNIRVGPMEGPQNNDHRAVEGAVGHQLQNRICSSVQQLPTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ97</accession>
    <name>A0A914HQ97_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ97"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3453.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3453.t1"/>
        <property type="gene ID" value="Gr19_v10_g3453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3453.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23546" checksum="891880E7C80F7633" modified="2023-02-22" version="1">MSSQVWRRGSLKIWPFINDNICGFDLSSSDFFRFSPTILRHCAKLRLIKSHALFPQFAANDSVGASFGQTSANWLHTPRGDGLPPKVLKCGFYSTGMEGLKREFLNSVDRVNYIIGLFVRAGVVPFKLKNNLTGERLVCRRFNKYKWLLVRCPIERDEDKWENEAFKWNWCRPWNSIHINFNDGNIGDGMLDANDGPSEPKKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQP8</accession>
    <name>A0A914HQP8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2820.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2820.t2"/>
        <property type="gene ID" value="Gr19_v10_g2820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="RCC1" evidence="13">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="13">
        <location>
            <begin position="266"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="15">
        <location>
            <begin position="610"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="773"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2820.t2"/>
        </source>
    </evidence>
    <sequence length="818" mass="90224" checksum="E57FD10F7E72C34C" modified="2023-02-22" version="1">MTESNGSVGQGAVHNGISMPFWFGFVHVKADGESVQIEDNLSLKVSRFKVPKDGDEKFSIADVGATDRFIFFLGQNAICAFDLRTEMKSPDGSSDEKWAPVEVELNHSEVAGTSCSSAVALSQQFCHWNALRGRKGTDKFQCSVFPKSNRFLVCTAFGAFLATNSGDRAILKRICDSRLGHNLLETKTFYLPFPIQKIRAGRDHLTILDALNDQIWSLGTGTRGELGDGRVEADNWGEGPSFADVGIRCVDIESGAWHSLALTAEGDVYGWGWNGHGQLGQPSSEFSIQPMPFPFDLGDETAIAIRCVGNNSFLLLSGGNELAFGEICADQKQKMAARGTDTSVAGGQQSAEIGVEKDANAGGDGLSPAPKRQRQQRLLRMAVVGCSHGQLDAIYDRLRELEGQRNVKFDLVICCGDFQAIRNHGDLQHFHAPFHHRKLGTFYKYYSGEKVAPILTLFVGGNHESSGFMAELPNGGWVAPNIFYMGYASVVRFGGLRIAGLSGIFKPGDYNRGKARGSVVSAYHVRSVDIFRLRHLKDASPPLDIFFSHDWPAGITDFGDWETLLRIKPHFAEDVRANRLGNPATMDLVHELRPAHWFAAHLHVHFTAVVPHSDQPAGPGASVTRFLALDKPNENPRRRFIEFLQFPIAEDAQMELAYDPQWLAILRATDELTECTDGTVFMPTAILTPKTSDIDALLPTLGSDLRIPFNFRHTAPPEREPWNSKGRPPSLYYRNPQTQQFCERLGIRDLNLLFAQKSADFLGVPHFLNLTPSSESQPELRPLTEATTTTAANPDEIDLGVDEFGSEDFIVDVPEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR01</accession>
    <name>A0A914HR01_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR01"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2901.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2901.t1"/>
        <property type="gene ID" value="Gr19_v10_g2901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2901.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19751" checksum="3CC5EF3C2BB5E245" modified="2023-02-22" version="1">MLCWSADHSPLFTFIANRFAALGHKFGQKDVPRRGRIGNASYLVLIDTDMLCWLPTLFFGFSGLTADHAEQCDVGSGVVYPINSCANPLLYMFQARFNASRRPCCAYRWQCAGRLTACFFEMINYHQVEDVHVVGVEETSQCVAHFVGRDSRPVHDVQANRIVDSFLKRTTPFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR55</accession>
    <name>A0A914HR55_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR55"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3697.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3697.t2"/>
        <property type="gene ID" value="Gr19_v10_g3697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3697.t2"/>
        </source>
    </evidence>
    <sequence length="121" mass="13521" checksum="E52F82A16204076C" modified="2023-02-22" version="1">MKQMMEQFKLNMGHSEQNNLAVHQKANWKRLLGNWVHACEQSNIGSFNLELFPQTILTLIHLMKMFCRLCILKLLLTKMHGHGTVAQRADGIRAALKSDSDLVGIVMASRSTGGDGVKGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRK4</accession>
    <name>A0A914HRK4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HRK4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3806.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3806.t1"/>
        <property type="gene ID" value="Gr19_v10_g3806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3806.t1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44561" checksum="1BF7B418B64B9125" modified="2023-02-22" version="1">MEEDGHEVHMLIPIRDENQKISDKNVEVRLNVQYFMPKMQTSPSLFGVGIPLEYDKIYLDIASDLKLMDKLRSEKFDVGITETFYMTAYSLAIFHFLGIPVTIATHSQPMAPFHLYLLGVLSKMKTQINGYIGLPTFNLLPSGEDRLELLNFKSREVREEQLKLRKAKVWQNCVDQTMEKIKEFINQDVDYQKLAEEKYFLNTFPSWVEMFKSTRFFFLNSLPEVDFAQFKIVESIEKVKFIGAFNLDRPSSLNTNAIQHTNSLINLTLGTKKGVILVSFGTIVDSFFQVSSHIIEALVETMEKFPNYLFIWKQPKGDLPILKEFKFKNVILQNWINQKETLAHPKTMAFVSHCGMNSVMEGTFYGVPMVCMPLGCALNGIGIDQKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS08</accession>
    <name>A0A914HS08_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-glutamyl transpeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS08"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4127.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4127.t1"/>
        <property type="gene ID" value="Gr19_v10_g4127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000009">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="566"/>
            <end position="568"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="618"/>
            <end position="619"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4127.t1"/>
        </source>
    </evidence>
    <sequence length="741" mass="81591" checksum="B174166C46B019F4" modified="2023-02-22" version="1">MVDTFGQPNPLVAFKDSRPPSASGSRRNNGLKSASPPQMYTSEEAPMAAEEYTGTTTVNSSPCKMPNSGRSNGSSNSFPKARNIANTANSNNNQRTESLLMRKKGLPWLLASAFVVIVVLLILCGFLLYVLYEHHGFHSQIDGTRPNSQVPQTQKLHQNSVDEAKTSTKWPKQSQKSMEVRFTRAAVLSENGICSEIGRKVLLQGGNAVDAALSVAFCVGALNPHSAGLGGGFLMTYYRRFYGKCTTIDARETAPARTNKDIFGNSSHEDGGGSSQYGYKSVATPGLLHGFWTAFKRFGSGKIAWMDLLMPTVHLLSDGFPVSELMAKNLEENRERIINGSHSGMRSHFTNPATGQLYQEGELIRDNVLAETLKRLALSHEPLQLFYSVNGDMAKLIADEFAANGGFITRKDLHTYRSVVDEQPLLVTSEAEPKFVLCGAKPSSSFAITQLILAVMLKFYPPGSNSSIPWHSDEYYHRLIESQKHAFAMRNKLGDPKFDKISEEFALNMTRADFVDGIVAEISGRGVSKWKDFAKSTKEFAPENSGGTSQVIVVDADGNAISMTSSINKAFGSLIRSPQLGLIWNDHMDDFSQPNRTNFYGLAPSETNFIEAGKRPMSSMSPMVVYHKDSRKVKIVIGASGGTLIPTAMSQVLLQLLAFNHSLKEAIDTPRLHNQFTPFVTDFEKEFPQFLVQLLRARGHNMTTNSRNFSSSVQAILTDSEGNLLANNDFRRKVHTYPVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSC3</accession>
    <name>A0A914HSC3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSC3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3778.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3778.t2"/>
        <property type="gene ID" value="Gr19_v10_g3778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3778.t2"/>
        </source>
    </evidence>
    <sequence length="284" mass="31642" checksum="09A959E7E4A21F1F" modified="2023-02-22" version="1">MISRRPSPISKMIRWTELNSRFGTRPQNFAPQEAVFARHRLSQKWRPGIIGGGSGVIYNLRLRHSPQSTEDPLNILNEAFKYPKRQRRSPTEQNRNSTGTEEAKLKQQITEWERPGVVEGSAEKILKNWTSSGLLFHLKAKHKGTKFYEEFVHLESDKEDAQKKGTDPGAIRNSSSPRDEYCIEATCTALDQLGNTIIIWGCEPSQQPCDLYEQTIADHIKSKNVSCACSYGEKGINLTNVPSSAAKNSGSLAEIGNYDDNPIFVNMTGAYAAAGQNLPQGFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTD7</accession>
    <name>A0A914HTD7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3587.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3587.t1"/>
        <property type="gene ID" value="Gr19_v10_g3587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037679019" evidence="2">
        <location>
            <begin position="23"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3587.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="32763" checksum="0F13EFD3BE418C2B" modified="2023-02-22" version="1">MNAIAASLILVLSSVFMDSCSGLECKIGRNIIVDNSLIIKNSSIGTCPLDYSNYCLARRCIKAIFWGCENGKSVIDCIEQTQQDIEDKLNLTNIQCHCDYGEKGKDLTNVHYEVITAKPLQCKKGHFDSDGFGGTLVGECNDRDHFCFMASCAKGNEHVKQEWDCSRNRNCAAISERVGKAINSSVSCKCLFGKADVDMANENFTREMMSTTTTAKPTTTTTAKPTTTTKKQTTTTTDKPTTTATAKPMDKSTAPSEGPSANTPEANCSARHNVAIFCNMFMALGVLASAHSMLIGHRFNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTE3</accession>
    <name>A0A914HTE3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RanBP2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTE3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4286.t3">
        <property type="protein sequence ID" value="Gr19_v10_g4286.t3"/>
        <property type="gene ID" value="Gr19_v10_g4286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000089">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4286.t3"/>
        </source>
    </evidence>
    <sequence length="660" mass="72461" checksum="AEC01EA17C1858CF" modified="2023-02-22" version="1">MEGSASIDVGLLVLRGNEALIRQKLTLLLKITIPKVRQRLYVHLEEMEGIRALLPTIYLNASTIEPQIDLRVLLDIKRNIPVDRVFYDEVKDPDRPSFPMLREENGPVYSMNNLTATNHAGKRYEHVVLGGTFDRLHNGHKVLLSEAAMLARKQITCGVTDGKMNESKILCELLEPVGKRCRSVVEFIEDISDGISCNAQPIYDPFGPAIEGNHFQAIVVSEETLKGGKAVNAKRVENGFNNLDICLVDVLKNDCPDAVLKENKISSSLKRRELLGTVLAEPRKPKEAISNEHYVIGLTGGIASGKTHIAKYLADKGCEVIECDSLVHQLYENNEELRLKLKQEFGDEIVENNNINRNRLADIVFGNKEKLAQLNALVWPVVVESVRATIKQTKKKIAVIDAALLLEAGWGDYVDQVWTVFVPRKVAIERVCVRDKVSEDKACGRIDNQFPNDQRIAKSNVVFCSQIKVPVQSSADCFLFLRTCSVLCFKTHKESGKCKTQHNWKQIHGLSHFNEEISIGDQKFLQEINQQMKGIGGGRDFRGFDGGGRVTPRGGRGRGDGRGRGAFGARGGRGGAGARGGGGLEMRLGDWNCPCSNVNFAFRKECNSCHAPRGPQGSGLPQGAFAGGPPPPGEFPAGGGPMRGYDSGGGGGFVERSHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTF5</accession>
    <name>A0A914HTF5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4057.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4057.t1"/>
        <property type="gene ID" value="Gr19_v10_g4057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4057.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27445" checksum="4A56BE6D40B1B0A0" modified="2023-02-22" version="1">MTVFGLVGLLTGGKQREQDVSAPRKCIGLMSGRKSPRRSYHREWSQHYEQRSSSRSRDCERDNKGMRKSSRNRDEGHGNVRREESVKQSASNEELLRPNITINDNDVTGSVVRQAEIDRIEGPGFQPSSFRSDADTSRAKNSADKRSKQCKPNATKHDKAMFGPMWARKEIEREQMKRQADGREETLRDDVHQRTNDRLGIRFPLAHDLLSHDAELRNQQWKELFKERRKKAMDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTJ9</accession>
    <name>A0A914HTJ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTJ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3637.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3637.t1"/>
        <property type="gene ID" value="Gr19_v10_g3637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036779252" evidence="2">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3637.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8918" checksum="87E7B7A2CB771B54" modified="2023-02-22" version="1">MASQTLRMALFLAFAAFLVVQCSCDDSSEQVEFGEPSDEIKRQLSSPEKLAEGPSDRRKRSSVLAHESKPPGRRLAPSLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU83</accession>
    <name>A0A914HU83_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU83"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4037.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4037.t1"/>
        <property type="gene ID" value="Gr19_v10_g4037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4037.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14978" checksum="CEAEDBD24DD797E1" modified="2023-02-22" version="1">MKGQGIAAGVYITPTQPHLILPFTQAAPSVLLRFSSFGFLHPNQLINCSPKCPLTALRSFVDTVPRGKRLPQCQREQKALASSDPFHSPLFEGHFNQRNGCYYNELRAHQQQQQKMKVISTSKSWSDLKARNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU99</accession>
    <name>A0A914HU99_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4537.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4537.t2"/>
        <property type="gene ID" value="Gr19_v10_g4537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="14">
        <location>
            <begin position="396"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4537.t2"/>
        </source>
    </evidence>
    <sequence length="1672" mass="188493" checksum="05323A0C9E5D9496" modified="2023-02-22" version="1">MFSKIFAVYLYESVRISEAQLSVKESVKQQKNRPLGTLNLPLDHKISKLVRLSKNFIVQLTFRIVDDANNQPIEHFQQTFVRFTHTKSPDHEVFIVAKEHKKLNGYYQLEMKMSRDFVRFNSRPGKYNCELILGDSRVRSGLRLEIFDAFLDISKQFQPEEPSYKPRKRDTPNFERMPEIQHKFKKIEGCKTKYWTTLSYAFCFVCFLPLILLSFNWRVLTLKALQNLFSASDNANFSAPIFFNMLIALFSLYIICWVLGTSIAIELQLTVICAIPCFFACHKMLNALATDRIEIENEALRLEWSQNDHNDDLENDYYYSEESESFDNKEPDENVIQSASRQNRLRKYDDENIRKLRASLSEHENKSQVPAGHKLYYLNMTTSNQKKIDQLQFDSTTLTFFVNGIRIDVKSIDPRITLAAFLRDKLNLRGTKIGCNEGGCGACTVMVSELNPNSGEIRHYSVNACLSPVCSVFGKAVTTVEGIGGGQKRIHPVQERLSRAHGSQCGYCTPGFVMAMYTLLRNKPEPTYAEVDECLQGNLCRCTGYRPILEAFYSFTKTNGQKTNCCREEKCCMSSNGLVETENRCDSNGRKTHNKLSNLCTLPNIESSQELIFPPELTFGAWNQKSFMMENDGYYWYQPVKMEQLLALKREFPNAHTLIFDGSSTLKIFHLFEHFEVKKMDFVQFVDKLPNQKTKIFAEICNILSLFAGNHVRNMATVAGNMATASPISDLNPIWMASGAKILLKSEEANRIVCLDQNFFPTYRKTLIAPDEAQRREDDIAIVTGVFSVKFYQNKGPRVESMQMAFGGMGATTRMASKPTQNLKGRIWDEALFNDLSGALADEFRLPENVPGGMAKYRQALVLSFSLKFYLYVREQLGLTCEKREMLHLSEIENKFESTQIYQDVLPSQNKTDPVGRPLMHSSGEKHTTGEAIYTTDVQLPSDCLYMAYVTSPVSCGKIIGNPDYSSALCLDGVIGHVDWRDVPGSLMISHSNDVPLFATDQTSISYHGQPIAAIIANDNETARRAASLVHVEILKPDYEEKTIITIEEAIRHQSYLFPEPFRIHSSLNEPNATIKSEIDWKKFSRTIKGQIRIGEGDEMHIISSTQSVNDVQGDVATVLGVARNVVTVTVRRIGGGFGGKESCTGLFAGAAAIAAKKFKKPIRFWLERFDDMAISGNRHPFRFDYQFALENDCDKIAAMEVNAYSNCGYSFDLSKGVMERALAHIDNVYKFGNVNVYGHLCKTNLASNTAFRGFGGPQGMFATETIIKHAAEQFGIDVDTLRELNMYTTEGDITHYGMHLRQCNIRRCWTECQKLSNYDQQKLKLQEWNSKNKYLKRGIYMVPTKFGIAFGFKRLNQAGALVHVYTDGSVLISHGGMEMGQGLHTKIQQIASRCLGIDVSMIQIIDTATDKVPNASPTAASVGSDVNGLAVKNACEIILKRLEPLRKELPNESTWKDLVMHAYINRVQLSVTGFATIHCEPVDFTEGRGAEYYSYCVYGVGCAEVEVDCLTGDHRVIRVDIVMDVGESLNPAVDIGQIEGAFVQGFGLFTMEELKIRPDGVRLTRGPGTYKIPSADDAPRQFNVKLLDGSSNKNGIFSSKAIGEPPLFLGSAPFFAIREAIRNYRIQNGNLGYFRLDSPATPERIRLACEDSLLEKAIPQPSKGQRWTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUD4</accession>
    <name>A0A914HUD4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Aurora kinase</fullName>
            <ecNumber evidence="16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A914HUD4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4079.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4079.t1"/>
        <property type="gene ID" value="Gr19_v10_g4079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="33"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="13">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4079.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33399" checksum="B81397D55870DFFC" modified="2023-02-22" version="1">MSSESEYIVPNDILQDEQQKAKKKKVSWSLDDFEIGKPLGRGKFGTVYLARERETKYLIALKVLFKKDMDKHGVAHQMKREIEIQYHLRHPNILRLYGYFYDDDRIYLALEYAARGAVFGLLRKNIKFTVGNSARMIYQLADALRYCHSRNVIHRDIKPENLLINTNGDLKIADFGWSVHAPSSKRTTMCGTLDYLPPEMILNKEHDKFVDNWSVGVLLYEFLNGKPPFEHDKHADTLNAIRKVNYHFASSFPKGAREIVSKLLVLEPSARMSLEDVQNHPWIVQNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWY6</accession>
    <name>A0A914HWY6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWY6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5241.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5241.t1"/>
        <property type="gene ID" value="Gr19_v10_g5241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043653">
        <property type="term" value="P:mitochondrial fragmentation involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000147">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5241.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17016" checksum="6D4681CE1FC36668" modified="2023-02-22" version="1">MDVATVVDEYIDPADLERFRKAYEEQSRRGSPSAMAVFNYAHALIKSAKDDVNTGIFLLEGLLKRSEEDIPKRDYVYYLAIAHTRIKEYDRALEYINLLLSAESDNHQALDLKELIERRMKRDGLLGLALTVGFGGAAVVGVLGAALLARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY66</accession>
    <name>A0A914HY66_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY66"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5744.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5744.t1"/>
        <property type="gene ID" value="Gr19_v10_g5744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5744.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10212" checksum="A149539FF52ED81E" modified="2023-02-22" version="1">MEITNDDVCAYNLGFVRAMFDMAKSAAGHAGKGAEWNNLAESFRNQITEIDALSTELTIFVPNVHFQNPKANSAHKKVPSPSDVGANPGEYSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY75</accession>
    <name>A0A914HY75_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5571.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5571.t1"/>
        <property type="gene ID" value="Gr19_v10_g5571"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g5575.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5575.t1"/>
        <property type="gene ID" value="Gr19_v10_g5575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5571.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5575.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10478" checksum="A7BC006FFB94D672" modified="2023-02-22" version="1">MDCPKTGSHYAQLHENLFTLVTDQKGNYTIKHIGRHDAQLHENLFTLIGRHDAQLHENLFTLVTDQKGNYMIKHVIEHGLPEDRETRCAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYE1</accession>
    <name>A0A914HYE1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HYE1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5249.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5249.t1"/>
        <property type="gene ID" value="Gr19_v10_g5249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11397">
        <property type="entry name" value="bHLHzip_MITF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="188"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5249.t1"/>
        </source>
    </evidence>
    <sequence length="477" mass="52981" checksum="B561DABDAC5CAFDE" modified="2023-02-22" version="1">MDKDSGGRHTGTKTAQQHHHQQQLIQQQLQKSQQQQMQRPNTGDSQHTQQQQQLDEFIIDEILSLEGEQQGQRTNHLRGQVPNSYSCAENLHAQPSRPIPLHTACSRDSSNASIQSGSPGFQTAGAGFGLYSPKNESEFRQIISSSAPTSCDIENFIRRGNVTNAANTPFSNGGDQNLTEAEIFKDRRKKDIHNMIERRRRYNINDRIKELGLMLPKSTSEEMKLNKGTILKASCDYIRQLQKDREIMIRQQQQNARLEDLTRQYFQRIQELEQQLEKNGINVPPSNLPVLGAFSPSSGGSVSGNNKSIKQEPLEDGNCPQSVSFSPSSTPQTSKIATSLQDMQITSPLGATQQHATLLKMSQSGAAQQGFMIESAPSDMANYLSQHPNGNGLNILQQQQQSMEFGGCLNWPSAQSQLGQMFNAVNYGELSMEEFPFQNRGPLQGQDPLIGSSLNNQLSPIIQWDQSGFSPGNDTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYP7</accession>
    <name>A0A914HYP7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase ZNRF1</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase ZNRF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Zinc/RING finger protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914HYP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5888.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5888.t1"/>
        <property type="gene ID" value="Gr19_v10_g5888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000235">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="302"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="115"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5888.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="36724" checksum="9D1B2E52B4E45BF3" modified="2023-02-22" version="1">MLLWSVDSTRLSSRQSSDPMGQRPSMQQSEVVRRPRAGSELSNGTARTTGSSAAAHMHHHRRPNSIRFRQPQNDTSSASSVSSASPASAHSSADEGVGGGAELARHLLTNFGLAASSTSSASPPALNIRKPGFDGSSTTSLAQQLSGGGGASAPSTSVRPAQSSSNVSAHRRSAGGTAEQRHNHRRLGGGSSGAVSSSSQQRVGRDDRRGDGTDRLQALLQSLEAMANASDSSSSSAQPTTVQLNKLRRSAPLLHLLGRDIKCPVCHKVVPSDDVEMHLVMCLTRPQLSYNDDVLIIDKGECAICLEEMEQGAQIARLPCLCIYHKSCIDEWFKRKNTCPEHPGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYX5</accession>
    <name>A0A914HYX5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HYX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5372.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5372.t1"/>
        <property type="gene ID" value="Gr19_v10_g5372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
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        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
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    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
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    <dbReference type="Pfam" id="PF01053">
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    <dbReference type="PROSITE" id="PS00868">
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
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            <begin position="1"/>
            <end position="22"/>
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            <begin position="82"/>
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            <begin position="88"/>
            <end position="98"/>
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            <position position="251"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5372.t1"/>
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    </evidence>
    <sequence length="443" mass="49022" checksum="45F9E7B834B3223C" modified="2023-02-22" version="1">MLVDPLRPAAINNKRSAQSIDDAEPALKKRFLDEENDAISAQKTTSELNRKFIGFATTAIHAGNRPEQWDMNQVVPPISLSTTYKQSKPGEPKGHDYSRAGNPTRDVLQENIASLEAARFSRVFSSGLGATAAMANWLHAGDHLIMADDGYGGTQRYFRDVSVAHHGVQLSFVDMTKLDDLRAALRPNTKMVWFESPSNPLLKVIDIEAVSKAVKAHNPESIVVVDNTFMSPFFQNPLALGADVVLHSLTKYINGHSDVVMGSLVTNSERLDAHFLFQQLAVGSVPSSFDVYLVLRGIKTLHLRMGQHQTNATAVARWLETDPRVEKVLYPELKSHPQHDVHKKQASGMSGMISFYLRTDLEGSQKFLANLQVFTLAESLGGYESLAELPALMTHASVPQEIRQKLGIDNNLIRLSVGCEDRLDLIRDLDIAMEVATGRSREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ71</accession>
    <name>A0A914HZ71_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
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        <property type="protein sequence ID" value="Gr19_v10_g5842.t1"/>
        <property type="gene ID" value="Gr19_v10_g5842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_LTR"/>
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    </dbReference>
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        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
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    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1146"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1190"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="1579"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="2157"/>
            <end position="2321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1084"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1477"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2466"/>
            <end position="2517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1117"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1481"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="2507"/>
            <end position="2517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5842.t1"/>
        </source>
    </evidence>
    <sequence length="2517" mass="282173" checksum="41143D912BCB3802" modified="2023-02-22" version="1">MPGSAIGSTSSTGATAQSTLSEDETLIKVVNKTLLQMKQSNATVRVEDLEKVFGEVIRLEEGTNRALRNTNRNTNQSQLNISRLAGEINTGFATVTTQISSLAEKVSILEKHNLGNAPTGHNPTTNLPMPNQQPNRKTPHATQPQAVQPTAVHPSQSQPTAAMAANDDDDEGSDTLERTFQSINMITDASPIPLEVYRDDCIVTYDRWAKRFREYMDAFGKKLDDKDKLARLVIYLDGVPKRILEKMDTSRKSTIELALTNLRTDLDSPQSQGLSRQALMACRQIEGEPVKDFLNRFIPLAEASVADVKDQSQREGQLRELFLERLRPNISLVMKMLDMSRGKKFEQLCLEAREVEGMLAAQNSGMPFVQSAQTVQAMQGTSQQFTPTAPAGNFQTLTPTGPNRFPDRNAPMRQNGFRPQAPRNAPWFREQGNRNFGRGQGPAYDRRWNNRQVCTYCKRVGHVANACRTRTRDFQERQGGTAFQSRDFRDQRDRRPPTSGANAIQQDRTMALLDEIAQGMRTLSVEMGKQKSLNDVNAVVELTRATAHSQISIKESASNDKPKIEPERIASWEKVTLGPKLFPLLPIIIMINLLALLASSTAAAIPMRPMICQTEIQPTIWSLPMEHNTEAWACRKIKKGAKKFTTLSGVPVSETISPEMLTVSVDECRRMAEHKTCDRGMLMENDGLWGTQHEIDLTPSLADRIVLMGHHGKRGLFCFQNSGNCTLKDKTVLIWTPETQTNCRYTSVGRFKGRFVANTWLSEDAQYGLHFKNKAQKVRSCNNLLEISEQGFATRVVSSKRSRSRRDHDSGEGLGLVTSPELNAQLTYLDNDWVESLTYALRHAFKAQCDVVAKQRELSATAYLMDPTGLARTLFNNTKLYATRAGSSLLKIWPCVQLKKGEFRFKPTRLAKECFDKMPIEFVTKSMNRLAFLDPTTMIIHPDSSKVPCTTHFRKAVVQIENQVLEVDQVTGETKELPVKKFNTEPRFPEMFELAKHSFHQTALINVTDLNSHAFVSGMVRAKQWKELSDELEKEVIGDYRLTWLFLWLPILLETYAGPGWLGRMLVGKKRPRPALEPVELERIAQRSPSPAPTEELQGVQGDPRSWPPSVSIFPSRLSSSNPESGARNTDLRTINKPTGMRLRPASIALGGTSAVAISLALITSLSLIQPSDAATAHSNSLGQNFDMESTTALLFAMAVALGLVMLSMSRWTRYFTSETAAKTKEANSWATAPLKNLKLEEIVAMNVPTTPRLSATIRAFINGRPISCLVDTGASISLAPMSLAQALGCRTQPTSFNVRSASGHPIDIRAAAQTHLEIVGHKIFGDIKLVQDNILSDRQDYQLILGCDLMAELPPITFDFKQGKLSIQGKSVPLGERGSVLYSNVKVTALKDADLPPGSFCVLDGKLKAHSQLDQVITHSLDKRLGNAHVGLVSTVTNPNNGNIKMILTNPTDAPVRIHAGMHVALANELRQSAEEPWLEEQKRQVKEEAHEKSSDEEDPAFAIDFSKGSAKGEDLRKLKELCEEFADVFSKSQYDLGSCLVGEHDIITTTEEPLSTKPRRTPFRFREEVRDHMEKWLKTGVMVKSDTPWISNIVLVQKKDGGLRPCIDFRKLNEVTVPDHFPLPRLEVVLEKVGNCHWYTSLDLSSGFLQIRLTERASRKCGIITEDDVFQMTHMPFGLRNATSAFARVMAHVLSGLEESVIAYVDDFLIYTKSPDFKEHLDALRQVFGRLRQYDLKVSPKKCVLASAKMEFLGFVISKNVYTPSLSKIEVIKNLPNPTSLKEVRSMVGMASFFRKHIAGFSTTVEPLTKLTRKEIPFVWESEQQIAFDKIKKILCEKPVLRFPDYTKPFHIFTDASNVGQGGALMQKDEESKAFHAVAYCSRTLSASERKWPTVQVELGAIIYALRQFRPFIYMGNVELHTDHKPLAYLLQKADAHPNLARWLIELQNYSIKIVHVAGKQNLLADALSRAAHDCCSEEEIKNLKELEDIAEFPACLSLSLESRLVMDESVNMMTLRGANGNSYTVDLKLEQKADHEATAFIKFIETGEMPEGMNETEKERFALMTANLIFKSGILFFKEEGLRPRIFVPASLRPLVFDSFHSSPLGGGHMNMKKTLRKCRKYFWHRMHADIVNWVRSCITCQLRHMPTPGYRAEMKLPQSNTLFAKVGLDLAGPFPITKEGNRHILCIICWFTRFVIAVPVQDAKATTLVKAFLSSCYLKFGGCTELITDNATAFTSEFFREFCSTLYINKRYATPHWSQRNAITERSFRTFHNIMAKYISSDQPDFDEHLDMVTFCYNTATHQSTGESPFFLMYGRDPIFCVDQMLDPRTAQAPMATDLADFKFKLVSSLRSAWEATAAESAEAQLRAKAQYDKLVRVLEVSVGDRVLLRNYAGKVGTSRKFHLPWKGIFRVIEVEGVMITIVSCNAPQANPKIVHINQLKKCVDILGPACTVPNISEEERDALKKAGAKEVQNMAGYDHQGQAAPPEPEPGQQPKEAEIVPRHTHNLRTRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZD0</accession>
    <name>A0A914HZD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5185.t4">
        <property type="protein sequence ID" value="Gr19_v10_g5185.t4"/>
        <property type="gene ID" value="Gr19_v10_g5185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057096">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24522">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FERM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5185.t4"/>
        </source>
    </evidence>
    <sequence length="594" mass="65118" checksum="5F41A07CCC427E64" modified="2023-02-22" version="1">MPSVEGIRTSVPARKSAATTSLLYGEAEAQFLQGMYPCHEKHFVPMAAIVAYRLYGAEWPSEVNAALLSHILPCHFVPSGASITSLVSKLRHAHRSLAGRSPVQLQLHFLSLCWSLNVYGCTFFRAFMLMSKPLRGNLQIHLGLNDWGICMINASTHKQMAAIEMDKLDVKFTPNTNFLEVATRRKDLIATITTSQAVLINNLLKQLKLKVQQANRDRAVRGGIVVPCAAASVAAFSVPSIPAAPAPLSSVGPSGKDARQLPDEQKRLSHRQNGMRTCCRACRLRRCFQAGMRPELIATGDSISSPKPKVGPSVAHLPVKVNSFSPSSPGSFSSFPFANRISQSVRDFCEGEKAICAQHFGLGTVFGEKQLLPITQEEHNVIEKGCVVLLLNFVRTQFPKIDSIPTQQKVSILKSFTFHFNFLHYCELTLKHRPAVEGHRQRSRARANSSKWLLAARFWPGFATSSRTHTYKSLAIEAAEFAAIQGIQLWKCVEECVDLSAEFGTDHCPLDALFAELHYLIAASNGGGTNARGVAIRFGRILSMLTEVSALGRELNELLTLCKVFLDPGSCVNSNDLWDAMFAADSAKANATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZQ2</accession>
    <name>A0A914HZQ2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CXXC-type zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZQ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5274.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5274.t1"/>
        <property type="gene ID" value="Gr19_v10_g5274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022056">
        <property type="entry name" value="CpG-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12269">
        <property type="entry name" value="CpG_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="11">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5274.t1"/>
        </source>
    </evidence>
    <sequence length="621" mass="71344" checksum="09627EF2E8F32BF3" modified="2023-02-22" version="1">MGSTKKHSKRKGSEKLEEEVEKHCICDSMDYTTLMICCDYCLVWFHVECVKVTETTAKIIKKFACNFCSDKDPKCVTIYKKWAKGVATEQKASKSDKKKGEESAEEKKIKSIEKRKGRDRSTPKQSVKSHIIEKREAAVDDTKTEDESNNKDTKKAKTAQTKVKREQSKTPDSDWTPKDRPFLGTSITAQQKHQLELQETNPNLRCKKCIGCFRENNCGKCFTCVQNGGKCCMDRICVQVEELLKQQVAKMVDEEEGMGSGELGQKKSRKGRKPKNISAKAEEAKTKGVTGKNHRFDEAQRRHTSDESTVNVQLKRAYDNWMRRRNKSNGCSRTAVLQQEDLQCSGLGCTHSARIGSRYCSDSCGVALAKQRLKEILPQRFNVFFETAPNSQTENSEQVQQIQGKVGEINGKLDELEQWKNNVHRFVVALKNNTQPTSPQKKPNADENMLVGCPVCHGEFPMRESCRHIHMCFVRSERQTTYGTDYLIPNNQYNLYCEEYNKIDRTYCKRLRFACSEHYRDEYGLEMCGCPLSWYKKGGSLEFHELFLSLDDFIGDDGFCQEKQKSCRDHKNWVQTAFSLIDNERLNLLNKYEELCEQRRSLQLKLLQRGDILTLLCNSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I187</accession>
    <name>A0A914I187_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I187"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5948.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5948.t1"/>
        <property type="gene ID" value="Gr19_v10_g5948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5948.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39946" checksum="584746BB530D94C0" modified="2023-02-22" version="1">MDKRLKEIFICDDVLFNVLAFCGPFVLGLKIALIRDRFDFLVDAHFRTKEWALGDLKICRASYGNGTEIVKIGDDNVEHRLPIPQDPLPDNVIEFKSIQISYIDQSAIEFLQRIRRLFDSNGTNVWIETPDDQNRSWGIIWHRIWPLINDNICGIYLPFNKLNRLRQFSRAILRDCAQLRVIHCGSIFPAFPADDSAGTSSGQALAKWLHTPRGDGLPKVLESFAHLPKMEGLKMPVNFIICLWDASSSADIVPFEQDPSPAFELKNYWTGERLVWRRFDKFKWLLVRCPIERDEVKWAEWEQEAAWHLPWHWCRIDINLADSDISDDGLLDASEGPSEPKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1Z4</accession>
    <name>A0A914I1Z4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1Z4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5871.t4">
        <property type="protein sequence ID" value="Gr19_v10_g5871.t4"/>
        <property type="gene ID" value="Gr19_v10_g5871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5871.t4"/>
        </source>
    </evidence>
    <sequence length="559" mass="64866" checksum="51260266A1DFBE71" modified="2023-02-22" version="1">MANSVCASPPYQWNLTNPGNNVQIFAQLIDDIYKKCPQPIDKLSFNYTFVKYASEVANFRVIDNNEERRPTFKARSGVNYAADEFAIPKTVVDQIMQLTFSFAARILLFLLFIIHLMALANGKCKHFCRLIKCWLHELAIMKMAYFHFQLFKLVRMGKSLLNPSGSISVLEAILIESNAASAIITNERPPAVHTFLKQYFISKLYRKSNKLKQYIRLKFGSNMTKVDCAFVHFGREMERRLEENSFISYPNFSEYVERMEEEECDEVPHNQNAQNTPPDLGSKQLTMKLFHEPLWNYARAIQIDSHECKAVLQFADALSKIINFELNSDKKNEYSMDDHIMEEYSCTNNSCPLLGHFGLSKCRETIPKFGQILFETFYKYLDDVKYDEKRQLLSFPSARSEYFLRRLFDFVQRLKSTTLSNIGDDLDFVKTIQNIASMANIDHGPSSINSTGFFGFKIKNINKMVELNLPTWKLPYFIYLENKKELEQENALKNFKFIHSLSEYSLTIYEIIQMANILGEINKVMLQTVAYSFLINSKMKAAEQKSTKAISVHELFRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2N1</accession>
    <name>A0A914I2N1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L28</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2N1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6285.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6285.t1"/>
        <property type="gene ID" value="Gr19_v10_g6285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6285.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18863" checksum="601391C93F9677E2" modified="2023-02-22" version="1">MSPGSFGEMSLICHQNVVLSNCVPQMQLRRLKNPTRQKITSSIRLATTECRTCQKLTSVNSSCKDGVPPEQIKTEIFKQFLTLFADPMPINEILAFEGLECVDQMKPFLKNCDADKDGKICMYEFKCIVSALVDKVVDANKNKCISNDEMGAFIKRCGLESQVELDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2W1</accession>
    <name>A0A914I2W1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914I2W1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6994.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6994.t1"/>
        <property type="gene ID" value="Gr19_v10_g6994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="60"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="261"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="610"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6994.t1"/>
        </source>
    </evidence>
    <sequence length="809" mass="91315" checksum="A22FD33793F3EF1C" modified="2023-02-22" version="1">MDLAEVDFEDESDYEQLNAIQNRKQKKAGGWQSMGLDHTVFKGVLRKGYRQPTPIQRKAIPLACDGRDVVAMSRTGSGKTAAFVVPMLQRLKRHDTRGIRALLFSPTRELALQTFKTVKELGRFTGLFCACLIGGDSMDEQFNVLHQHPDILIATPGRLLHLVVEMDLKLNSVQFIVFDEGDRLFELGFADQLKEILKRVPDSRQTLLFSATLPKMLVDFAKAGLSNPELVRLDVETKLSDKLAMAFALCRQVEKLPVLLNVCRVLSNQKKKTIIFCATMKHVEHLVAVFQHADLDPAYLYSQLDPVARKQNITRFRNDECFLLVVTDIAARGVDIPLLDYAINYHFPPKPKLFVHRVGRVARAGKSGISISFVSPDEMAYLVDLFLFLGRPMQFVQPDDIAGNAKWNKNPDSVLIGIFPDTMAHMETEFLRTIEQNSIEISDLHRKAENAMTKYQRTRQQPSAESVRRVKSEFRHISPGPHPFFADPVLFPDFALEQRAEGTAAAFGHEVLVQLKNWRPNQAIFELRNTLGGAGIMKTKECQTVVSKQPSRAEERRAEERAEHFVDYVPSDVNTERGLALRGNSDDVGGGGISGGDMFEDAARAATVDMGADDERGMHMDNKRKMWDRKRKKFVSAEKGQQQPVKKMRTEEGTLLPLDFQRPQGDDNEQDQEEHGPKNNNQRMRRGAEFRNKKGGGQQQHFNKDQNRRGKFSKRGTTSAKGKPTAGGGGGGAKGELRNMDQVVKARRKKANIQSYQTHRREENLRKRDKAANRWKPKGARSDQQQQQRGRGAKGGAGGRRNVRTKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3I1</accession>
    <name>A0A914I3I1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3I1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6539.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6539.t1"/>
        <property type="gene ID" value="Gr19_v10_g6539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6539.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19657" checksum="FFEEB039DBDC2A3B" modified="2023-02-22" version="1">MFLLFINNFFQTVKCHHINVKRQLLLPQFVIGSTEQHEQQKLMAIVMEQQQKQLEQNRNVWGNKLPHSANKFVLRRPCYFSPVQCLLVTPGQHRAFVNHPKFNDHVRPSADAVRHRHSLDNSVGTQEQQRVHHPHRHHRRHRLNSAGSNGAGGIQRQQIFGKPWRIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3Z7</accession>
    <name>A0A914I3Z7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914I3Z7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7103.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7103.t1"/>
        <property type="gene ID" value="Gr19_v10_g7103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="10">
        <location>
            <begin position="136"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="11">
        <location>
            <begin position="368"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="681"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7103.t1"/>
        </source>
    </evidence>
    <sequence length="764" mass="83375" checksum="902DB667A71D01DE" modified="2023-02-22" version="1">MSDEISTILSHHHRQHHAAPAAAAEGDGAAATARSVPPVSAPSPPMPPIDHSFQPKHLTAVANLDDSADDEEGNLVRNLSATTLAEMHAEREANGIPPPQQQQQQQQQQHTGRRRLSTVCEDGHAHGKMVALHDSKVLVLYTGGTIGMRTCPAGVYAPEQHYLPRAIRDIPPLNDKEYAERMYADLPLKPLCLPPVRGMSKRVVYWVVEYEPLLDSSDMTFDDWIRIAKDIRKSYSAYDGFVVLHGTDTLAYTACALSFMMENLGKPVVITGAQIPVAEVRSDGRENMIGALIVAGNLDIPEVCVLFNNKLLRGNRSIKVDTHGLEAFDSPNMAPLATLDISINVNYESIFRSGELRPFTVQESLCRNVVVLRIFPSMPIESVRALLRAPTQGVVLQTYGSGNIPLRREDILREVRTAVERGCLVVNVSQCAKGQVATSYMTAKILDDAGVIFGSDMTTEAALAKLAYVLAKQEWSIEQKAAMLRKNLAGELSVAHSDAQLVGELDIIPRLAKYLSITSSSETRMLRNALFPPLSCHAAFANDVQTLENLRLSGANLSGGDYNMRTPLHVANIINLGWHPPTFGEGKVGDRGSSGVAAVEYLLKHGASVHIRDANDENALICAVRSRNLVAIKMVRQAGGQLVLPRPRIGVELCLSAGSGDLEALKAWHAAGANLSTTDYDGRTALHVAAARGLDEMCYWLCENGADPLVRDRLGRTPAEDARANIDEHMVEGLRRRRRWHIKVFAQKSSRVRSSFALLAPFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I464</accession>
    <name>A0A914I464_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914I464"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6448.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6448.t1"/>
        <property type="gene ID" value="Gr19_v10_g6448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037317947" description="beta-fructofuranosidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="139"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6448.t1"/>
        </source>
    </evidence>
    <sequence length="648" mass="73956" checksum="8CEE206012EA58E7" modified="2023-02-22" version="1">MLLLAFLFATSLFLIHGTGTEGVSRVNVLLLDDSTLHVWVRPVKKGEVAKVYLCPPTEAGTIEQSGQLIAECKQYSSDLWHDFIEINGKTAGAYTLTWTETTHASLVYVFKPKTVLEEGIRILFIGEEAKLPNLEGSYHFRAPFGWNSDTCGFNRSKDGLFHLFYQHFPHAVQWYSMHWGHAVSKDLINWVHLPIFMIPPNLLHLDFENGHFTGSSINLPNGELGVFWSQRISDVPRGTVAEYPWRELQQYVTTKNLIRPDWTTHKTIIERFPTVDPPLGNNFHDPVVFLGPGGYYYMTVGAERKNGSAGLVLLYKNKNKNADQLDRDWEYQGVLYEDKRNEELRMCECPMLIALGDPLNANTEWVLSYMSDGGSHPAPIRGTDAEGRDRMNPLFVGRFDGRKFEHRFVQKMDFAGGSFAYQGFYDKQSGRSYLIGWICDISWISENTGDPNFDGRGGATKGQQMHLEKGQAELVFEFSWDNGREETFELHLTPTHTNGKKLEFRIDNNGLQLKRTWVTSNKRLVVYNAMPTKIHIFIDLDTVEYFADEGRWSGSIRLPEASQEKRIGTVELKRAPLMLKEASMWYLNYKAHKSAFLQQTANIIKMEPIKKHIFEKQKSSPKSVLDAEFGESPKKGELPALHTIGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4K5</accession>
    <name>A0A914I4K5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4K5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10978.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10978.t1"/>
        <property type="gene ID" value="Gr19_v10_g10978"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6840.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6840.t1"/>
        <property type="gene ID" value="Gr19_v10_g6840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10978.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6840.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34116" checksum="CBE5C9F336D6D082" modified="2023-02-22" version="1">MNRTALRVCRMISLLVSALLCCSAVILLTIGVATPSWLYVDYLVAEGTIEEHRHGLWLDCVLRGGGGSNPYAQSSYLNWGVTSDQCEYKWVNIGPSYGSGGAGIDPYLSNSGYSAMSSLFQTDYSQHRFLAWHVSTMILLLIAITAGVFAIFACLCVLCTGLCSPVAALLEFVAFISSAIGVTIFFINANRPEIRYTQIPNSAERWRVNEQMRGFSFDLSLASVFIFLLSCLLGVLGSVVVFMHAQHHHQHHRRMDSKTFPKTEISTVSSTANDHNHLSMTTNMANQPHLIRIRNDGTGGSVIRDNSIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4R9</accession>
    <name>A0A914I4R9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">cGMP-dependent protein kinase interacting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRARP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4R9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7516.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7516.t2"/>
        <property type="gene ID" value="Gr19_v10_g7516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21930">
        <property type="entry name" value="IPD_PPP1R12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000007">
        <property type="entry name" value="Phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031775">
        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15898">
        <property type="entry name" value="PRKG1_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="cGMP-dependent protein kinase interacting" evidence="9">
        <location>
            <begin position="929"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="580"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="661"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="787"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="929"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="507"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="891"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7516.t2"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109838" checksum="A438070238002FA8" modified="2023-02-22" version="1">MPKLPLFFCFPPLSPSLSSISALLEQIFAQRGGRNILTGTPKEEAKSKDTPTVSIPFLSLILCISLTHPQQHHTISLIPPSGRTKKMVLDDDCINMSMDAAMLQNKGQIQHNVTSKRKEQLKRWESSEMNQVCTRRRPEHKSSVKFQDRDIFLSACVSGDEEEVEELLKNGSDINVSDIDGVTALHQAVIDSNPNMVRFLVDHRAAINAQDNEGWTPLHVAVCCGSLSIVKYLCEHGSDLSCVNSDRELPVDLAESDEMRTFLEQEMRRKNVDEQKAREREFTLLFEDCNRWIQSGHYLDKPHPRTGATALHVAASKGYNKLIGMLSRAGADVNAQDFEGWTPLHAAAHWGERDACRILMENGANLDALTHTGHTVFSLADKSISDYLVNLQEHQQQQNGAAAAPHSNGSSAVLQDMANLTMNREKEPSVDSERASKRSSSVYSSSDQDHSSEHCASTAAATAVHATHSTSTSPSLGSSSVLSNSSHLANTNNKNNTGDQKQRETTNSSSSMHSSPSAASSLLSSSNSINSNSNSSGNPNEQQPSSPASLVSSSTSNNTNGLQTSKSTTLKAAETIQRLRQQLPQGRSKTQSVDFGKALSSPLDTNPRLKSPPGTAPLVQSARSFWNSVHSNSSSSSANNVPQHPIGTTPLHQQQFNRFRQRFQQQQSVDSLSSTASSDQSGTETAKYPQSPTINPNRLHHRRQQHQLNLQFKNHHLKDSDTAMTIMFGNDSKNGTLSTAESSVTNVTATNSASESASCSSVTPSPSPSPIVASSVTLNSSPFVTVRKQPHCQQSTPPTQPISSRESEAERKAKSRLKRSTRRSTQGVTLEQLGEVSMRHHAPKHHGRTENGKEQQKQRTATIGRLGSDNSLELSNNKLTPNDLQPPPASPCSSTSSSSAYLTAASHRVVDQQSQKVQQQQNSTMPSSTASLIDELDKYRQLYERERDESERLRTERRMFERRIVALEYELEKSQQLQTDNEKLKDENIALVRVLAKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I582</accession>
    <name>A0A914I582_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I582"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6731.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6731.t1"/>
        <property type="gene ID" value="Gr19_v10_g6731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="1">
        <location>
            <begin position="61"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6731.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24570" checksum="26968E290A575D57" modified="2023-02-22" version="1">MGQSKSKAMPDYEAPLRQKIQLLYNIRDFATEIVSATTEVIDAFNVPGPDPKRTHNVAIGLAAYLSVHGTNCSPFFEEYGKFLLFMRAGYDKISREQAIFHQKVVDKVIEPFEKWLTVDYKHMHEQIMELRERAKRQHIAATNFAKKKGIDRMIAYELTNREFQLQLGIVKLQLGKLEKIREAHNSYLRQLIEAMDDYNDRISKILEQHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5C6</accession>
    <name>A0A914I5C6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5C6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7668.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7668.t1"/>
        <property type="gene ID" value="Gr19_v10_g7668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="111"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7668.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25491" checksum="2A2C15407EE7CB5A" modified="2023-02-22" version="1">MLHRSSSSSLPLLSNALAFVAHSAFPRRTICTSPCAFTAFDPRVFTDPIVTTGELNKILPPDDKRNFMYIIPMKSDQTPVFYRDAIVDKMRTQYGKWLNEKDEKKRAEIILDPIEVANRAILNCRPLMKLEKTIRAGTLYLVPMPISEKVAIFKAMKMMRDICRVKAGKSWGEKRAHYPHFKDVLASELLAAMDNEGMTIQAKQELHKMCEQNRSYSSMKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I639</accession>
    <name>A0A914I639_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I639"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g712.t1">
        <property type="protein sequence ID" value="Gr19_v10_g712.t1"/>
        <property type="gene ID" value="Gr19_v10_g712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967">
        <property type="entry name" value="GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967:SF12">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g712.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24699" checksum="1B095C2DFF15687D" modified="2023-02-22" version="1">MDKDEQNAYNEPMKPNSPRHKQLMKVRANLMAVLSETKIPFVMFESDAIWLQNPMEFFAKQQTVLDDANVVLSLNSIKGRQRLAANLIIAFANNGTRRLLQELRRQLNHDENLLDQEVIMNQLCHSQFGGVLCRQFSLFDISDGIWLRLSDGERLARRWPMIVHNNFYTQIEDKMARQAINGFWFLSPKNSCNLSKAQRILEKYNKIKKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7X4</accession>
    <name>A0A914I7X4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7X4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7740.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7740.t1"/>
        <property type="gene ID" value="Gr19_v10_g7740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF282">
        <property type="entry name" value="CUTICLE COLLAGEN SQT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7740.t1"/>
        </source>
    </evidence>
    <sequence length="367" mass="36298" checksum="50E1689F2E903E5D" modified="2023-02-22" version="1">MNLIALPLTFLVYKCLVSCHHFKVNLYSSQSNLSKLAMKVYAATFLASSVSGVSLLACLVLIANIYSDVQEIWQELDQQIAGFRAETDDLWVDMMKLGKKLRVRARRDAAGYAGGSAPVGVAPLAPVSGAASSVATASAGSGSAPGIPPGGVSPPSVPPSIQTGGPGGAGCNCQTGAANRCPAGPPGPPGVPGQPGKEGIDGIPGLSGKDALDVTPEAPQYGCFNCPAGPQGQPGPIGRTGPKGHPGAKGQPGHSGRDGNPGPPGEPGLPGPAGQVGPPGLQGEKGRDTEQQIGRQGPRGQRGVQGAEGPFGDAGLNAPPGLPGPAGEVGAQGVPGGQGVQGSHGEEGPSGRPGPDAEYCPCPQRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8F8</accession>
    <name>A0A914I8F8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8F8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8445.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8445.t1"/>
        <property type="gene ID" value="Gr19_v10_g8445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8445.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="12376" checksum="1CA1C26CB4988B70" modified="2023-02-22" version="1">MDSPAQKRKRGRPPKGGATKTNIAKAPVTKVPSPSKSPSKSPQAAKTAAVVAKPAPARGRGRPPKGTGTSTAVPKKKAAAAPAGGVGKRGRPPKKKAAAKTSSGESASDHDDGSDHDKSLSKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8M1</accession>
    <name>A0A914I8M1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8M1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8299.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8299.t1"/>
        <property type="gene ID" value="Gr19_v10_g8299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8299.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15487" checksum="6FDD91F9E6E6C216" modified="2023-02-22" version="1">MEERVEERRKKGRMKEEDGRKMEERVDEWKKDGRKGGRKEEDGRKMEEREDEGGGWKKGRMKEEDGRKMEERVDEWKKDGRKGGRKEEDGRKMEERVDEWKKDGRKGGRKEEEREDEGGGWKKDGRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I902</accession>
    <name>A0A914I902_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I902"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8391.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8391.t2"/>
        <property type="gene ID" value="Gr19_v10_g8391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8391.t2"/>
        </source>
    </evidence>
    <sequence length="240" mass="27307" checksum="133A5271B0D64464" modified="2023-02-22" version="1">MFRKPKRKEHLRKPKAQERHEDEEEEEDLEEVDSRIQDVLEAQKVRQRRFGMDAVECAVGKDLAREFHRLDENPFQMRGGAMLRLSDHQKAALNAADIEADIKEQFKKETLLRDEHEEMRRYVEARIAAECPAAMAAKGGGGANGVGPSDSKRPKIAGPEDDILFKAAERVKQYGSKRNEELLSNQMLVGIPEVDLGIETRMRNIEATEQKKVELLKKGIIPQPTSNWQPVVVVEEIEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBV8</accession>
    <name>A0A914IBV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9173.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9173.t1"/>
        <property type="gene ID" value="Gr19_v10_g9173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9173.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19452" checksum="45B742B5FA50D78D" modified="2023-02-22" version="1">MGMVLLWLGWHEQRRLPGRTDRMSTVRMQTKPKSVRMSTARMQTKPKSVRMSTVRMQTKPKLDHFIRPNTEPALNVDATPELGIFGCLIGNTEINHFIRPNTEPALNVDVTPELGIFGCLIGNMETGKVSYFSRTGHMMKTKLASVERAESGRDTVSAIRHIWSRSVIGKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC87</accession>
    <name>A0A914IC87_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multiple epidermal growth factor-like domains protein 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8869.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8869.t1"/>
        <property type="gene ID" value="Gr19_v10_g8869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000041">
        <property type="entry name" value="matrilin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037586953" evidence="9">
        <location>
            <begin position="30"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="11">
        <location>
            <begin position="46"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="663"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="706"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="831"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="928"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="971"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1009"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1181"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1223"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1352"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1458"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1498"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1498"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1509"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1077"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1205"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1248"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1377"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1478"/>
            <end position="1487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8869.t1"/>
        </source>
    </evidence>
    <sequence length="1519" mass="163539" checksum="52CDF0BF2D44B624" modified="2023-02-22" version="1">MRIPPLPFPPQLRLIFWSIFFVLFSLRNGLDVQVDVLNPGILQLGQPNVCPHEELEIVTVRRPCVRAFVKYVRTRKANCALTLNAAGCTVREPKTFYYHSTTNSTRKRRQLVPECCPGWARVSGEKGCLRSNCTTDLCQNGGTCVPPTSPFAVQLCLCPHGFHGFTCQFDVNECSTGNGGCAHECVNVLGSFYCRCHPGYELAEDGRTCEDVDECAVSNGGCEHLCENTPGGFVCHCPAQLQLSPNGRQCVRQLSCSVQNGGCVHLCEQRDNGDFRRCRCRKGYKLAEDRRSCLVEDPCVPNRCQHFCLNQGNGRAKCQCYPGFTLGDDQLSCVDIDECREGGAQCQFACENAAGGFRCVCPEGMKLSSDGRSCEPMEDLSRELFYTNAHFHHQNPNSERLKVRGVANHQNLQRSPHFSTGRTCDYGRFGASCEFICDDCQNGGGCDRTKSRCVCAPGWQGDLCQFPCLEGTFGNGCAKRCQCGGGVCSAISGECLCPNGTCGDDCPTGFYGLNCTLPCRQNCRDGHCDKQLGLCVCPPGLFGEKCDQPCPLWTHGPNCRLECRCSREGTANCDSQTGKCFCKSDFQGQFCRRRFCDLDNEECRGERHPGAKCPPGFTGDRCEETCLPGKFGTDCAFPCHCESGMCHHSSGACLRMDCPLGTFGPDCALECPCQNGAACNPINGTCTCPQGFYGAACTEKCPLGSFGTECMKTCECQNGASCDPNDGRCLCMPGFHGPHCERICPRGTYGVNCLKLCKCESPSSLNGTVAKQFDRLEYQTENGESGGHGNDNEPDLMRLELIDCDPMNGECICPPGLHGHRCEQKCPSGQFGVRCRGVCACQNGAQCDPTTGACVCTPGWRGQRCERPCPDGFFGERCRKRCACDSPGLEGTAARCDHIGGQCECPEGWTGDDCRQKCPEGRWGAGCRGQCQCQNEATCDPTTGFCDCLAGWMGRNCEHECPLGLFGPNCLSHCLCANGGQCDAVSGVCLCPPGWTGKSCEFPCPFGLFGLNCSEKCDCSNGANCNRTNGKCQCLPGWQGERCEVPCPEGKFGLNCSDQCQCQNGAKCQHISGHCQCTSGWRGRKCSRACSKGFFGQNCAQICRCPGKGSCDHIGGQCECPKGLTGPSCSQRCPPGTFGVGCAQKCSCGPNEQCDPETGKCFCKAGQIGKKCENGCPAGKFGVGCENCECENGAQCHPETGECTCPPGFIGTRCEVPCPENRYGPSCSKLCDCQNGGRCDQNSGECRCAPGFTGPHCTQMCVAGRFGQKCREKCQCADETNCDPRTGHCKCGPGRTGPACQQECPQGKYGFNCSMECDCHGSVGCDPVSGCCHCPKGRYGYRCQFECPPGQFGWQCAQPCHCQNGASCDPVSGQCLCPPGFHGDHCEQLCPPGAFGAHCLLRCECGHLPTSASSPSPLAASSIIGCNSISGACDCPPGRVGRNCEEVCREGFFGKGCQRECECYNGARCNAEVGKCQCTPGYLGATCQNELKDPDRVAKRGDLPDNEYRRRRRGTNLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICV6</accession>
    <name>A0A914ICV6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICV6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9031.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9031.t1"/>
        <property type="gene ID" value="Gr19_v10_g9031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038080822" evidence="2">
        <location>
            <begin position="27"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9031.t1"/>
        </source>
    </evidence>
    <sequence length="805" mass="93277" checksum="B0CB11AD40F4E004" modified="2023-02-22" version="1">MNSFYWAKTAFVSLLMISSIPFKATCTGPVSALFNSLIVGITSANEGEHSAASTSNQRPLELKLADAQMLQQWIGQIARKIVVEDGIFAGNYLCCPNININAVILTDGLPKERIKNLLKEVQNLEEKSQFLKLLFSFGAMLSAEIGEQSQQYGTLRALLKAYECVGGQFKDISNFAIAAVIKSPIEKLKVDKIILESLQINNVNHRLIQEFDLLNALKISEMTPKDVINFASFIRYAFLKINPEMQRSVCNRYDVYLSSDILTYPKNPFKKGFLKINELSHSILGKDPIKYRRIAHQLLLHVKNWGPDELKKISSKKSDEEDVIKLTRREKCIFGIFTLNLLQRMAKFELFEKYFGELNMNRLVEITNENLSVYELFLLTRCNKRSLEEEQAKELKQKKKPKNDGIENSKFYPFFGEAIRIDWNIWTEIIQQIDELPKTVKSLRSKYQLAMHTESVKFENAMQIVKAKFDEKKFGLELKAKVNLEVQLFELFYSFAARLEAIVHGKNIDGTIEKSRENSKDKIRAFLAVPNCFNVPEWANKFSIFDYWMEIKEINSESQIPAIGVEIFRNENEEAKSISRENYKTLKRLNEHKFSFYESTKHLKRIYSVIWHMDEWDSEIQAEVEQHFGKYCKKIEGIARKADLNTVRYDLVLNFKLNAWKDVHDRTKDLLKKWAENKSYEERAFAEGTENVIEPTMTKEYNPKENCKDLNKKTQGEPSDYEKTVEELGEQIDEASHGVTGELDALLIECKIERGENELKNGKEKEIDTLEKELKENKESAREMSKNFGQMLENVKKLYGQKMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID53</accession>
    <name>A0A914ID53_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914ID53"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9508.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9508.t1"/>
        <property type="gene ID" value="Gr19_v10_g9508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF29">
        <property type="entry name" value="ELONGATION OF LONG CHAIN FATTY ACIDS PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9508.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="32125" checksum="C673F048A2079202" modified="2023-02-22" version="1">MLDIFLSAPYSHRTAKQWLIDYEPFLLKCVLIYVVTIFTIKFVMGSRKPFGLQGPLAIWNAILAVFSIAGFVYITPTFFRVISQKGIQYTYTQINEIHTDKTAGYWCFLWCVSKIPELIDTLFIVLRKKPLMFMHWYHHTLTGWFAFVTFYEDNAYMVWVVWLNYFIHAWMYSYYCARAVNIRVPPQFAQLLTAAQIVQFVITHFVMGHLLYLMTTTSRKYAVTGRGFAVGAFMEVSYLLLWFRFFYISYIAGGGKKYAAHQNAMSTKNGNAKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE13</accession>
    <name>A0A914IE13_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9353.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9353.t1"/>
        <property type="gene ID" value="Gr19_v10_g9353"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g9355.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9355.t1"/>
        <property type="gene ID" value="Gr19_v10_g9355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9353.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9355.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9258" checksum="00291DDD3961AA19" modified="2023-02-22" version="1">MPAKVVIGPNTVKACSSSSKNPSGSSSNKNASSSVDAKFSCVANHLVFFSVKYEKHDNNVQNRSHRVPRRFIPNVLQLITMIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE23</accession>
    <name>A0A914IE23_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE23"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9751.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9751.t1"/>
        <property type="gene ID" value="Gr19_v10_g9751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9751.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7338" checksum="A251314A6D152084" modified="2023-02-22" version="1">MADGAKDTMPLEGEQIRGMANGWTKYDEPRRYTLGQLAAKSVEQMAGKAAENFVLGSAKGHGDNCRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPZ6</accession>
    <name>A0A914GPZ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPZ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10269.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10269.t1"/>
        <property type="gene ID" value="Gr19_v10_g10269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037608960" evidence="1">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10269.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17324" checksum="AADD00A405904B7F" modified="2023-02-22" version="1">MVVQSIFLIALVHPIGTRFLDRKVDNCFYALRHRGTASAELLAKMVEWKMEDIKQGNRPNEHDCRGNFAGCQTYSCLDGAGANIFVINACAPDGGNCTHGDLDPFCSAEIGTPKCEICHRGLCNRHKVELTAAANALSVPNSSSNANDTDEGAVEEIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR29</accession>
    <name>A0A914GR29_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GR29"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10519.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10519.t1"/>
        <property type="gene ID" value="Gr19_v10_g10519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="144"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10519.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29785" checksum="84BD524CFDEE4412" modified="2023-02-22" version="1">MIKIFFSIPHSLTLNNQIHISLKCFCGGAAADGGSQRIVSRSRCSVEVQRRFENLNGKMDFLRSSAMSGCEITLVVVHHCREALEVQWPPFIASRYTSNFLRDNAFYSSVEGLCSTYRLWMLECRWRKESIAVDTLSGPAKLSFVDVERVLSEMRERHPKQLVFLGTCVLEYSEGPFFSTHPIVRIDDQGLVLPGIFNNAARSSAITVDSLDELYESLQKFGRICAENTCEVQLMPGQRLFFNNARGMLGAPAQSGRNLVIKCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT07</accession>
    <name>A0A914GT07_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT07"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10480.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10480.t1"/>
        <property type="gene ID" value="Gr19_v10_g10480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10480.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30027" checksum="7C5FC5A4808C5746" modified="2023-02-22" version="1">MPFSSFSSPSNQQNNGQQQSSSAVRKRQQNQPHNAATHQRALGSKVVVLGNMGVGKTSILLRHDGQGFTSQMSSTLGASYICSRSKADNGREFELQIWDTAGQERFRSMNADKYLWRKGYAEKAQNLTNYDQFPFFHHFCVRRIGRDLESWIKEVERIDETGHVFLFVVANKCDLNEMRMVSEEEGRQFAEKQNAHYCETSALSGKGIETVMSAIAECILQEEQRLLKQSLELGNSVFDLASPAASEETDAGGAKGRGGGRGNGKGCCAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT15</accession>
    <name>A0A914GT15_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT15"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10123.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10123.t1"/>
        <property type="gene ID" value="Gr19_v10_g10123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10123.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29172" checksum="DC550D22262DBF60" modified="2023-02-22" version="1">MRRASTTRPACPCMKPDTACAISCCRARSALYAALWCRPPNLTVRPSPTRRTAEMLFFDESIGHEGSDDLVVKGHAKKIVAKRHLGRLLRSQQRREVAELLAEAERACQTLLRYRKRALQKISLELFAKKTLKYRDMKRILKKGPASSGRRRRRGENSRSSSVESNDRFDDIEGGVKYTFGCAPLSEVQEIGRRRESPIERAQSVEKLRTLTFRGPNATFPFVPGRWSRQKCVNRIGAVRSYKILFLDDVLFPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT23</accession>
    <name>A0A914GT23_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GT23"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1013.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1013.t1"/>
        <property type="gene ID" value="Gr19_v10_g1013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF16">
        <property type="entry name" value="BLACK MATCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="134"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="790"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1013.t1"/>
        </source>
    </evidence>
    <sequence length="972" mass="106554" checksum="245BD805FC68C286" modified="2023-02-22" version="1">MNAKMSNSPRPTARASIACDTRAALMALAPRQHAQPRAGSADKVPTPTGLEGMLNGGRSPLNSARSAAVPLRQQSVQQPNSVPKRSGSTCSSSSAVSLSNGAMSASPLTPSSAKRPMQMAPPGGTPLDAHFHCLQSAGPIVGGHWHHFLAQANVAQTAEKEVSLLLFDKKWNVKGPARIGRLNRLCLADLLRYDLTQLQQLQHPRILQLLKPLAENKDLLAFASEPLQCTLDKLFEHFVPEEVGGFVLEKLEMKLGILQLIEGLSYLHNNAKILHGNLTPQAVFIVSQQFWKIGGFAFSVASKKPNIFPCFPWTKKFPACLQPDLDFLAPEYLAPNTQTVTTAADVFSLGALICWIYAGGRRLIEVSNNLESHQIVIDQLDVALELLADELGPNLKGSLAKVLSKEVEQRPAVQMLALTKHFDDPALGALRQLDDLAQNFDPASKATFLGQTLCPLIAQIPESLWFRRILRRFDEHLLEAYELFHVLLRPLSQMLQHCESHNIHRLRPWFRRIVGRSDEKQLNNALLDQLPVIFRRLNDEQVEDRCFDLLIQLLQGLDPHLKQNAVRCIPHIAEFIPAWFVNKRLIPVLQSQAPFFQEHIPRQIDLLVAVAHLSDRCDAQTLHYLLTVASVCSTLHPAIVHSKSRLVQRILTCDVSRLRDPLVIAHHLLNPLVLGLALPELSPAHFDDVMSSSRILLDITEQLRYEFDDSRMKAENGGSRRLCNRRVSMSSNHLPRLLITAARPSIGGDGRKMSFLSADGRLEDRGSRRESKDSRCSLESEMSLRIYAGNGSDVSDESATMGSSGGGAGGTASAGGGRQTKFRRKSWLEQGYLHSMSLEQPPQSVTPQVPSPLPPPYANKHGSGGAERCSSAAAVGGTVQQQQHMAQAPSSNPMEQQRPFSTLSSCKMPHSAAGGPCGIAAGGAMRRSRSPEGTASAAANLLDDAGGRKPSRPNSFTNLGHNLACTLWKTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTX3</accession>
    <name>A0A914GTX3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTX3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11308.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11308.t1"/>
        <property type="gene ID" value="Gr19_v10_g11308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11308.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10647" checksum="311AA1860C7C7BC5" modified="2023-02-22" version="1">MADFKSLKVRHKLCSDKLNLEGEGMAGGARKKLGGRREEEQIAAKYSPKQTLAEKAESPPGDVVQWMGWEGRMICWKKSDCAAGEEYQSTKKAKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVH7</accession>
    <name>A0A914GVH7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g11723.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11723.t1"/>
        <property type="gene ID" value="Gr19_v10_g11723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF94">
        <property type="entry name" value="INTESTINAL NEUREXIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1311"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="409"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="657"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="899"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1530"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1111"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1530"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1550"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11723.t1"/>
        </source>
    </evidence>
    <sequence length="1566" mass="173036" checksum="FE27EDD032E0BF7A" modified="2023-02-22" version="1">MPIDGLSMNGLSSMVLSIDEFPLIIDGLSIDWFPLIIDGLSLTHDLCAKRPYALNLCPKKFKQKLWGLCGACLIKNATLKETGTLKNVNAPNDKVETAADEQFSAESLNALFGVLFTANFSSAAEDHKKSKPISSELLCNAQENSMCENARMCRRKENASDFECICRKGHAGKFCQFSLFARNCADAFAFHEEEVGHFLDGQNGGVWQLDVDGSAPLPPTFAECKMINDGEVATVVANNVPAGGAVVRTVDGTGPADAQNVFFPISYKLFSASQLGALIARSFICRQNIRFACEQSPLAFKENRTWLEVVSRDGKQHRQIGTHQQFSCACRNKELYGCGRDNPALACYCDDLSQPSAVDQATLYNASAGVSAVYFRASNIADLPQQQQQQFGGAQNFTLGPLECSGEAGTSLHGAAVVTLRSPSAGLGTGTLGGPWRQLEFDFRTGQPDIDQMVAGWDPDDNGLQMKISLRAGYRIELTLSHQASMEEAEKSAEINQNAAVQQQKREIRREMSISIASQRPLNDLFWHRVLVEVFRGEIRFSVDRLNAFQPLSFPFATSTKFTIGGDEKGNGFVGCLGNFQIDQKLLNWHEQLAQKAKDEDFQVVASGCVELCAEHKCEQDSKCVEHFDTESTSCACKLPRIHYGEHCEKNINTNSSATFRGGTWGFLRFFDLPVSALHSDVIFSVRTDQRRALFLYEHDHVDNFVQIHLADEYQIVLTLNNLSKIVSCSLFAPPAKTFNDMRWLQLVLERNAAGPGTTTTILHVDDDQCEIGPTLLNDQPLSDQQIDTTAAASVISDSNGRHEEAAPNDDDAILPPAPPVPPEKARFFHMLYVGGMPRAKRQRRERRERLPVYLSNVPQLKGCIRGLLVDGEKVDMREAITNRTLAHKNWDSVQIGCEHVQCDQLHCENGGQCSVNWNSANSAKTIQCDCARSSFTGENCTEDIGLSFIGNSSVVFDMAEPKRFAFFQQSDRQTLSFAYAVKNGTNKQRHAQQLATIYFEDGREFHVVLDRNGTLFVGVFGPEGPINVQHITGIFNDGLRHHFHVHFLSNNVRVELLELYGIRRSWLIACEGMNLANAQRFYFGGRKNVVENHGETVSTPNDQSGSESVSEERQRVEAADGKEADHADANSMPTDGIMPGPEHNPDSNLLADAMRQILARNVRQPQQQLDLRENGIQTVTKHLETTTIWWPQQIDHFIGSISSALIVFERDVHKLTFTPFLYYFQKSELLHRNVFNEPPSAEEPLAPTGCGQFKVPEKAKKAQRNVSFPVWEAPFGPIPFHDEVNSAKLVKDNGPSTAEKNGEDHEFARWLLILLLLIILSAFCLLLIAFLCRQTVRQLIGRTYVLQKPSAKLLSEQKRPMLKVETNGPVKRRFTSRSDSLEPIQLAQHKRFFPLEGSFCGIAPAVTPTAPPEPKPGASILRNFPVKIQSAAAITAPPAHAVERERAQQQDSAATAASSSTVYFTAQEEQFAENGAISSSSPAISFKSLDDPAISSAGEESTTIGQAFDENAPELFDENTLQLSTALSSSIGGSSHFSSENSIGGRGQKLHENHLKLTEKSDDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWW0</accession>
    <name>A0A914GWW0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWW0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11911.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11911.t1"/>
        <property type="gene ID" value="Gr19_v10_g11911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11911.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8830" checksum="7B30C4B0B2CBF4EC" modified="2023-02-22" version="1">MCEKRPSLEGLLSHNEGLTSSGSDKNGMLIFRPDLFRLSFFFCMRLRAHIFVHRQREKLLCLPSIAALRPELLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY10</accession>
    <name>A0A914GY10_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein farnesyltransferase subunit beta</fullName>
            <ecNumber evidence="3">2.5.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CAAX farnesyltransferase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ras proteins prenyltransferase subunit beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GY10"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11426.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11426.t1"/>
        <property type="gene ID" value="Gr19_v10_g11426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated" evidence="13">
        <location>
            <begin position="407"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated zinc finger" evidence="14">
        <location>
            <begin position="745"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="826"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11426.t1"/>
        </source>
    </evidence>
    <sequence length="1164" mass="134078" checksum="3C0A2858AE7E1454" modified="2023-02-22" version="1">MYEAYTNEEIVFKLPIEASSITCYASKEKLFIGSRQGHLITCNQAVEVQGTSKHHYEYQVCRTFERRPIVELQVFTMPLNLTRLYTSSQNIRRFRHFLTFWSRTKFCELCEVDTFVPINLQENAQVIVWCEPNILILAVKGACQFWNIELLHKNEFIDEKDFEPAKRPRLLELIRTGSSESAPLVVFLLKKTIVGICREGSVVDFYEPKTGKITNDFSSCKFSDQVLSLVYHHPYLVGILPKNLLEVRFQYYVWAAEEPSMPPMKKQFELAAQLSASSTQQIAIQRQLATKYFFERKFSKCFEIHTELKTDVLLVLNLFPFFIPEKYVAVLTRYPQAELQTFEVSLENIAENERKFATQALIQYLVARRAEQIALVNQHYLDYNSGNKARTLCTNELKRHEASLELIDTVLLKCYIKANPSMAKSLLRTKNCCCIVSEAEKDLNQYGLFEELLILYEKKKMYRKYLELLQREVKKHESFGIKDIANFLRRLKRDQISLVLEFSAPILFESVELGVQIFTSSTDDRETDLKQRAENDPRVKFDREMVLQFLKKECVQAVIPYLEHVIYKWNDERPRFHEELLEQYVMQKIDPYYSVENASNLIGDDENLMEESAIIMGRLGQHLDVLKIYTEILMDFNGAERHCQTYYDEKNASTHNEKRIETELRRKPNITEALKLFKRHPTKINTVGAFAIIPPSTLFNRICEALKALFETSNNQLASTNLIVSLTNLLIQRNKKRLKELKRQRISITESAECSLCKKRIMNSAFIRNRDHSFSHFFCYKNRMEKNERKEESDGFITPTVLEQRRVEEIVVKQKREWTRTHGMHLQNKSHVDYILACLEGLPKSYSGMDASRSWFCYWGLHALRLLGHKPGKALQNGIVSFLASCQTEDGGYGGGPGQMAHLATTYASVMSLITIGTDEALSSINLKTLNFFIHSMRQPNGSFTIHKGGESDVRAVYCALAVANICGLPVQDQLFEETASWLTRCQTYEGGFGGEPNCEAHSGYTFCGLAGLALLRKLHLVNIDAALKWLVNRQMTFEGGFQGRANKLVDGCYSYWNAACFSAWECFDPDQTKPFRKLFDTAALQSYVLEACQAPSGGLRDKPDKNPDLYHTCYTLSGLSTSQFYSSTKDEVLGGKRNIVETVHPIYNIHIDAYARALRYFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY28</accession>
    <name>A0A914GY28_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY28"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11438.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11438.t1"/>
        <property type="gene ID" value="Gr19_v10_g11438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF5">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="549"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11438.t1"/>
        </source>
    </evidence>
    <sequence length="671" mass="73187" checksum="B5919E79A3774F04" modified="2023-02-22" version="1">MFSSIYRLIDNLIIDYSLIVGQFVLRLPLRPNDGFSVSSSFFLHLALPSPHTVPSLPAAVTGSSATIPSPSAASPTRDTNALRMPSDPLDFLLCQSNSTKLPATVLVLRLFALHCSLSSSVEFCPSSASCHICRLFRLQPIRFFRNFRSSAAHSHTIVKTTVDECSCWTSSSTWRKQQLLAANRPKCPFTRGKHLPAAATFIVPFYDDLDITGNNGKTETDSAFVQPHGPPAPPDELFTYTTTIPPPPDELFTYTTTIPPPPDELFTYTTTIPPPPDELFTYTTTIPPPPDELFTYTTTIPPLSPPFPSNEKSFPTLVPPTFPNLERSIDGGSLTEKKEIAEAVLKNAEGLMDGSAGSERGNASTSEGKTMALKLPELMGELEEFGEGMQKGSENGRDSAGEDERGAGTADVRSAHQNGEDQQQVALFESRKCSAHQWNVRVRPHGEGQSQSVSVASRRDVPMPIFVGKGKERQQIIGEESANGKAITAQRGDDQQRSNSELVPGHPFASTALLTRSASSQSTPDQCGVGPNFVPCVPLGQANARILSCCQQKQMPTGCLALCRYDTTQAQMKQAFEKGQCGLLNIAPFLSCASQGQNNVQCCRHREIVKRSGVQCEVFCNPSADNARVPPRRSSFHNIRPSFALNERISRIHHIFLSSFFGIDSSPIQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYM4</accession>
    <name>A0A914GYM4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GLD-3 KH5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12344.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12344.t1"/>
        <property type="gene ID" value="Gr19_v10_g12344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041194">
        <property type="entry name" value="GLD-3-like_KH5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22801">
        <property type="entry name" value="KH_GLD-3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17905">
        <property type="entry name" value="KH_GLD-3_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="262"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Defective in germ line development protein 3-like KH5" evidence="3">
        <location>
            <begin position="329"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12344.t1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58422" checksum="F143B6325EF21908" modified="2023-02-22" version="1">MMMSASKGKFHHNNNNGHSGSRTFLPSQSMFHACQESSMLFNEFVRRNINSFEQRRRAEFTRGDNSLKQLPAATNNFPRQPLPTKLQLKIEVQGSDFASLHDGREAWAVNDSLAAIMEDTKCMLLFADQNDPNAESMGFFNQVTIIGDMPNIDCAMDRIREFSPITVAISLKNVKDQFKREDLAQLIRQWCLGDELGLFSRVQFSILFPPNPFIITQSEDANSLSLVVRGSRKDHKMMVNACEALLKLLFTENCREQFFAALEIPVSQRRMIVGSPEGVLISAISSETKATIHFPSSSSDCSLTYSTYLLSGSADSVIRAVRMIQDVSPVRIEFDVEHSDVVFPMCTSEEQHRELDMFDSERGVIVQVRKSAYEGSFRMRHEQMRHSLTLMTSEENVKNLYVVRSQLLLESHWGREPCVQRVLTSPRFLEYLKVLVMESAVRAYIGDGKVISVCRCRVHQQGFQQQQQQVAETCNASANIVENDMTNGRLSIDECDGGYVPELHTQMLFALHRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ11</accession>
    <name>A0A914GZ11_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-tubulin N-acetyltransferase</fullName>
            <shortName evidence="3">Alpha-TAT</shortName>
            <shortName evidence="3">TAT</shortName>
            <ecNumber evidence="3">2.3.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetyltransferase mec-17 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-[alpha-tubulin] + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha-tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15277"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.108"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase ATAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.108" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GZ11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12497.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12497.t1"/>
        <property type="gene ID" value="Gr19_v10_g12497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="site" description="Crucial for catalytic activity" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12497.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31867" checksum="1F02543A46E6C747" modified="2023-02-22" version="1">MVDVPTDFGVLLNAGPPIGRIESNKLNSFRKRQATATECMQNGINQIGKLAAEAQGLKRPVTSFARFSDSSDDQALYLLWEPAQSVEGGHSSTIFGYLKIVRDRRLYLADDDGRQYVTTPICVLDFFVHKSVQQQGKGVQLFNAMLKAEGDLEARRCAFDKPSVQLLQFLARHFGLERPIWQSTSFVVFHSFFEGMEPEKVSNAEDRLRPMTALERHRRTVNEQYNGQQPMSSRLSPLPAAQRDHAAALIHQQSAASGERTPAPPDTPQGRKVQRDYGHQRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ17</accession>
    <name>A0A914GZ17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12652.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12652.t1"/>
        <property type="gene ID" value="Gr19_v10_g12652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12652.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10426" checksum="D2CF9B6C5E41DE3F" modified="2023-02-22" version="1">MRRHCGWLSAIAPVEPVDATRKEVENMKARFHLKEIPFLRSLRVSILFRSSVSRLYSTRGNFVSRTCRFEVAGDYPPPYNWLSVRQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZA4</accession>
    <name>A0A914GZA4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZA4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12570.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12570.t1"/>
        <property type="gene ID" value="Gr19_v10_g12570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037986761" evidence="2">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12570.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="18449" checksum="9CD728D02A8E8235" modified="2023-02-22" version="1">MFAANSLLLLPIMLSFISLAFCADSSLVVSPAYSTKQTCLSEASATGPISAQLKKAQKGGKFTHYGIGGRGACGLDIDTPTKSAAGSGTLFNSSAVWVLSCLPDARYLLDDLVCINKCVQIQYKQKTLTVPINNKCSECAIDHVDLSEEAFAWLEPDTSVGVATEATITYIQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H011</accession>
    <name>A0A914H011_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H011"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12682.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12682.t1"/>
        <property type="gene ID" value="Gr19_v10_g12682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12682.t1"/>
        </source>
    </evidence>
    <sequence length="484" mass="56119" checksum="07BADCB2F6EF7DD6" modified="2023-02-22" version="1">MPDIPKKVKKQLQEIHICADLLFEVFEFCGPFVLGLKVALISDRFDFLVDAHFNSKKWSLGDLRICRSINGKDAEIAKYVDFKVERRLPIPQEPLPANVIGFEGLKISYMDQSVIEFLELIRPLFNSKGIHLTIGTSAFESFSWEIILQQIWPLFKDNICGFYLDCSKLDRLRRFSPTVLGECQKLRVIEYYGPFPAFPADDHAGASSAEALTKWLHTPRGDGLPKVLQSTCFYSERMEGLKLEFVNSTDAVNFIIYLYHSDNIVPFEPLNNLTGERLELRRFDEEFCLLIRSPIERDEDKWAKWEKEAVECSWSQWNRIIIDFGAMDIGDGPLFVNWNKFEKKPTEARAFWFPAEDSADASSDQALAKWLHTPRGDGLPKVLDCLFWVERVERLNGEFVNSTLPVNFILTLWNCSAYEILRCFDGVKWLLVRCPIERDEDKWAKWEKEANYCQGNRIRIDFKDSDINENFNDMDIGDGLCLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H037</accession>
    <name>A0A914H037_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H037"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1281.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1281.t2"/>
        <property type="gene ID" value="Gr19_v10_g1281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="495"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1281.t2"/>
        </source>
    </evidence>
    <sequence length="617" mass="67617" checksum="BD4BC79AE3056DDC" modified="2023-02-22" version="1">MQQHPQQMNSLHQQQANFMAAAAQQQQQMHHQIRSATPPTSTLGQRQQTFSHPVLMQQMRTSPQQNNLHSPQQFHLQQQPQQILIRHQPPMVGGGAGPAQQQPQQYTHFVRQQGVSHLVQVSNASSPVNVQQQFPQQQQSQIRHQQPMIPSPQQFRQQQGPPHTTTEAQQQQQQQQRIRYQQQQQQTNNIQQTMAQGSKLSPQQELHVLQQHFPSSQMGGVPFAQQQRHQQAVVAAAQFHHHQQQQHIIVQIRHQQQQHNHNGSHQQTATAPSQQQMVVIQQQQQTNPPQMMPMSSQPPMQQPQNVRVFITSQSPQQQHQQRPIVSVVHHSNSLGSPPAHQPMVVIQPQHHQPPMHSNGPPGGGGEILGRNICDSAHSVTFSGGVQQLQHIHPSPSAADSQPTAQQIDDTSPIIGGRETPANSKCVAATAPAKKVSSSTVSIASGGAKPSAASVAFRGKSAIVKGAKASPAADPLDLVRASGQRMGSRLLDRDALELFVKTVDPNEALEDEAADAVGMVVDDFVDELIRNSAEMSNHRGAVQLEARDVRFALSHRLRMAVPFDSSLGGTALAGGAANALNQQLSQSSIGGLPPAKRSAGLVAHQQRMALIDKTLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1V2</accession>
    <name>A0A914H1V2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1V2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13134.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13134.t1"/>
        <property type="gene ID" value="Gr19_v10_g13134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF35">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13134.t1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41546" checksum="BDFA9BE5BB511F1C" modified="2023-02-22" version="1">MQHVPSLWLKRKCSKKILMEKHLDSKSLCARGISPNEITHLVITHWHLDHCGNIGLFPTAQLITPERIMAEGSEAINNHLPKRISVHLYGGHSTPGDVVVRVKQMENQADKIMTRTIAIVGDLFEFENDWLFDQPWKQNSFCPSRQLISRFLCWKGADEIIPGHGPSFRLTTAFHEKSAIFGLVHENDAEMIGTASVCELFSFFAGQQQHKYTIYLIKCIGGETVLVNTGGPGQDQRLIGALDAHRIVPDDVKYLVITNLGIQFCYNLHLFKNAKTVMFNDIAFPGSYYDSLNHYFSINSEISVWRDMDPICETGTLSVLVKRRPKNFTVIGSKLDEFIPAFLDLTEDDIEMAKVVLHPKDERGAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2K5</accession>
    <name>A0A914H2K5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914H2K5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13412.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13412.t2"/>
        <property type="gene ID" value="Gr19_v10_g13412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019174">
        <property type="entry name" value="NADH_DH_b-subcmplx_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09782">
        <property type="entry name" value="NDUF_B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037227730" description="RBR-type E3 ubiquitin transferase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="265"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13412.t2"/>
        </source>
    </evidence>
    <sequence length="824" mass="96303" checksum="94BF4201C5A00AAB" modified="2023-02-22" version="1">MHSKWLIFVLILRFGFSEGIGKIRGIGHNQANENAINWAHFINKSIRRFHPSRYSSSNSLFYETNFQPKMPIASKSCQELKHFNKGYGPAGRITLSPKTGHILWHSAIEKDQRNEAVFIRKVIKRYACRFKFYSLIAPASHPFKYRPLSTLLRLKLQDEYQQGDEVAMEEVTNAGTSSSAALSSEEIKDYQILSQTELIDELSRLSTETAAVLGFKGSICKSLLHHYKWNKVTLIERFYETSDTDAFFRSANLLDPTKHSRIEGKTDFCKICYERRPLSGLFCNHLFCGQCWSNYLSSKILDEGRPYITCPELRCTVVADDDFVLKTVKSPQALRSYNRLILNSFVECNTLIKWCPAPECGRAVKVPHAEPRKVSCKCGFMFCFGCSQQWHEPIGCEKLKTWLKKCSDDSETSNWLNANTKDCPQCQVTIEKDGGCNHMTCKNLACKFEFCWMCLGPWAPHVSGSGWYSCNRYDDDAARRARDAQERSRAALQRYLHYYMRYTNHQNSLKLERKLFEKVSEKMEQMQMLGFSWIETQFLQKAVEVLIECRRTLMYTYVFAFYLVQNNITKMFEDNQSDLELATEQLSESNKRSKTNIVMWSSVVKLFLSTDTLDNKVEFKRALTDFVKMGNLYAAPKRVGPNPYTRSGAPPPKLVVRKDKDVPIHRVNDPMSLQLHMADERVRTAGLSPAEREWREKWVHDQNMHPDEPVHVDAVHRQLNPVRVLYRWPWDKLYKHFLRPTFGTFYGTLIRLMVPKYCWVFLSIEAIYYIWKYESKSWQKTKEHDKEKIKLGYTDYGRYDYYDRDFYENYKTADIDLGPSKRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4D1</accession>
    <name>A0A914H4D1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13734.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13734.t2"/>
        <property type="gene ID" value="Gr19_v10_g13734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="11">
        <location>
            <begin position="1421"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="12">
        <location>
            <begin position="1603"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1144"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1162"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13734.t2"/>
        </source>
    </evidence>
    <sequence length="1927" mass="224466" checksum="326CFA090BAD2F77" modified="2023-02-22" version="1">MKSIALQFIVNFIQFFSSICLIEGSFIENGKKLLIDQLYTEYILSPSLAYSSEIRACIKRMISIEYYDGTLNEFNESVKVKGIERLVDRDVCRFWALHRHMKQFHVKLIQFGEMITQNSIERFYAIFLEPNQCARLNHIRKTKDSKDKKWLMDFECDLADGHLFMLEEMLQNWHYAKQRKLAQVFLEQKADWENELTYRLRMIGYLKNLEDPNFLKTVAKHRMEELFGKKNANSGTLLYNKYPILTYGIDFFEWHYLLYAQLFAVEPSELSRIKAAMELFAYFHAIEMLFEQKAHPKSIWPTLRLDIARIFDSINSGTTKLFSLNESTDKARQLLAQVSKLKADFLQKKKAFVASSSKHTEALENPQLEADISRIRAELEHLITVEKTAAQNSEMFQILANLSELKLDMELYIKGIPFDYELNKINNIVTIQDELSQMHAEMIEKLATFNEVFCQKLHALCGVELTKRFSVILSQTQLAKIWPTVRMCRIKEAVNAGGWLQLTHEPSISFKNGEDTIEYHDDDASALAQSYKELFTNHELFSSSKSKFSSSTQHHQIQNMDILLKAAIWLGNNLIDEFLLFVDTMFEKENAVINQMLNNLWTLWDLLLKGTNEMDLTMINANEIDGIFTPHLSSIQLNCNAAQIAEHLNQLKDSPNYELVHSLTLFRLMKRLTQFRNIFSGSAEYVEAIKRSLFVVLGSSQEFELLEKMFPEHLRIDWLDKGYRVALYSNMLQQRSWSDEAQRAEMRMASSMLLRHLNVQLSAKTTIGTIDPMDVLRMHEIVKAKVYANIDKVEGVCWMMYLLNMMNRNGTFVVPSEPLVVYCVHEGARLHGFIAHWDKIQQWHYDFLTESKNGTPILVLMKHKVPGTMTRLWRLLGDKLFSELCKQYKEVCQYDASNKAFDDEHVLMYHYRRSIVFSEKVCAIDQLNSKLAADMLVFIRWFDAEPKSAKMATFWRAKREELKEEYDEIFDANLNDGLTQKILTFVQSCHSMKKLLFECRNWVNEKEMKEAWKKMLQRLANNDDRHRKHSGEGAERQRHAAFVEGKDWLNNLHAEELKKFLGFTNDGGEHKPVNEEQKKPREHFARIMREGLTKLMNARIQLLDFVGVKEAVNIFKMLGIKSELDDLDDELFKDAHIQDSGEKKNKKKKKKQKKKTKMTNTKNRDAKAKRNKSAKNDGIDVKNNDEMTARCHHIIDEIKEDEFLLGQYLQLLSNPSAFNVGLRRTLLEMSIYSNEIWHRIEVLKHFAKSALQFLHWPEHFESKWRELKEKNVSDMEEEELKMKLNKLAKALMASAALKNAWDKLTKADQICVITVIFVAENNNRKLKEAKRKSVGKYMEKWGQTLQQIRMDQHIFEMFDQKGLLNFGQKPAEWREHIEYIQQINYDGESNFSDEMAFILRANGHGGVDTDTKTQIQAHFDTIRTIVKQWSKGQGELLMGGSMMMGTFTSDSDVDTVCVVPEHIRAEHFFGTVSCHKKFNKECRNDDSLFCQLCLHPDVQSLQKLPSSWVPLIRLTLSTTDHELDIAFASILGDEQIQFEDQNILEKTEEMIDKLGNKIKTLKHDQSDQSAIDESEQLLRSLRSLAGINSNLRMLELVSDNEIFRKFILALKLWAKSNYIYNNAMGFLNGTSLSILATKIVLLYPEATVPFLLKRFFFTYIKWEWPLPVHIEDIRPDSLNWNAADELRQLETQFWLGSHGQRLTMPVITSGYPQQNSTFKINWQTEKIIKNAMQKALKVLHSSKSDKEKWTTILEQQKKFSEMYPYYFVITCVASDVNLFNEFCGFVVTRIRIQLLRTIDCSRDSVEFCHVLALNSCPQYTVQKYTNISANMCCKAWLVGVSVKKAENGQQLQNIDLELNNNNLKTNLDNAIVASYKKIVFDTRRRRGPLNLAEQKIQKFFSSKFSDEKNQRDFVRLETKYVDKSTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4S7</accession>
    <name>A0A914H4S7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4S7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13238.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13238.t1"/>
        <property type="gene ID" value="Gr19_v10_g13238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015929">
        <property type="term" value="F:hexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF12">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13238.t1"/>
        </source>
    </evidence>
    <sequence length="563" mass="65825" checksum="118DF463C0E2361E" modified="2023-02-22" version="1">MHLTNPFIPGYLAFCSGFRSQTPLLGHFFHYSTLGSEATFMYSDSKKIKISNFVRNVRFCTSFNSRLVGFLICIFLILIFAFYNLFDLELEFENKMSSPVILLTKSTSFKRQIVHLDLKGAAPKPHYLLELFQFFKKLGFTTILMEYEDMFPYKSGLSVLARKTAYNETTIEQLKESANAIGLDFIPLVQTFGHLEFALKHQEFSSLREDPNWLDTICPSNERSIWLIREMIAQVRHIHPDEKAIHIGCDEAWHIGLDRACQLRLNTLNGSIDRLKLEHISRIARMAKEEFGFDQVFAWNDMFDKIPVSLLEEYELGSLLIPVVWGYSRDVTRPGYFPSGLFERYSHIFEEIYFAGAFKGANGVTQQFVDIERYMQNLRSYQELYFLNEEHLKNRLTGIILTGWQRFSHNKPLCELLPASIPSLAREAIFLSEWRNGKRPEEQMNERLREILNCSKSPLAGDFAHKGAIFPFVFEVQLGECQFPGVELYREIEKLNVLRWQAMREHNMKAEIEEEFNNAKKRMVILLDHFFYEDTVNEWLTQHSYLSDFKDDDPNVPRFDPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H527</accession>
    <name>A0A914H527_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H527"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1390.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1390.t1"/>
        <property type="gene ID" value="Gr19_v10_g1390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="SPRY" evidence="4">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1390.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29559" checksum="64D8193C3AA07B88" modified="2023-02-22" version="1">MEEHQKQQQQNIDESTEMKQLNMDYLQSDQNALLERQQQKTDQKALNAPIDQAMDQLKGEMNAKMEKYQKHHQQTIDELKENKKEMLGESQWRRCDLYRIVGAIVLFIFVIYAIYGLNEQKQNRKWRFIKTYSNLTTTRASERNARNERIAEVCPNDDRIRNCFVSIGLGPLQMPLDKWVGEYKGTYAYEGKGIFWGNAVEGSIGRPFIGGKPSFGVGDVVGCGVNLATRQIIYTKNGRRLEKWNKLHIPYILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H613</accession>
    <name>A0A914H613_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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            <begin position="1"/>
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            <begin position="17"/>
            <end position="497"/>
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            <begin position="83"/>
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            <begin position="295"/>
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            <begin position="29"/>
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            <begin position="35"/>
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            <dbReference type="WBParaSite" id="Gr19_v10_g14320.t1"/>
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    <sequence length="497" mass="54645" checksum="8031A3A02531643A" modified="2023-02-22" version="1">MPTFLFLAAICLLVAASILLETDASPRKKTKFEKGSSSSGKAQSTPVPKANSSAGGIKHLLPAMSECTLSGTTDSADVHFLILPAHKAILAEVSDVFKAMFRYDEANAKAAAGTGPSEEIKPVEVLDVEVPDVEVGVFKAMLACIYAKDLSGLDGDNAISVLYAADKYNVSGLVKECLKFIWTLNVFFAFDLARFLGKEQLLCEILDRDELWISEEIAIWNAALRWADEKCRQKGKECSAKNRRAMLGTALFIIRFPLIPQKDFTENIVPSGVLTEDQQAGVYQYHSHPEAGLPELYQLQFTTNRRAGTGLTLQNRWDSDACHKKLALSEPARLIVQFTGYYYGYRSVFAKRPIPKGNSGTFYYEVTILEEEYGGIQIGLAKKEMPLDGWVGNYEGTYAYEYCGKFWGHAAAGCHLINRRAYIGGNPEFEKGDVIGCGVDLATGQIIYTKNGHRLETDGLHVDFGADLFPCISLTNPGTKIEANFGPNFKFNIADGI</sequence>
</entry>
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            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
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        </source>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14653.t1"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6R2</accession>
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            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
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        <lineage>
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            <authorList>
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        </citation>
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    </dbReference>
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            <begin position="521"/>
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            <begin position="198"/>
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            <begin position="61"/>
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            <begin position="85"/>
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        <location>
            <begin position="98"/>
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        </location>
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        <location>
            <begin position="115"/>
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        </location>
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            <begin position="450"/>
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            <begin position="532"/>
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    <sequence length="572" mass="64899" checksum="87F6900DC8A217F2" modified="2023-02-22" version="1">MHISCSFFFLLTLALFTCVILTPLDEGDNGNGQKNQTENIDKQVEEMRKKLLAWSDRVKKRREEEEIHHSDDSDHSETSHIVDQPPQQKGNKQTMALRESRHDRGGCDVDGQEAAGSSRQSAATNRLGYLRSKSDDYARRNEFHESGRRQIVQYSKVPPCQIGSSKDHHIPTHSKKNVSGHGKQIVMYTEKPIIQKRKEKSMDDLQTLQKQMNAMMAQNSENKKGMREEAEALQAAHNVVPPRSAIQPKFGGFLDKVTRKMTPEPENWKKGLANMLKSDVQHTRNLRDQNAYEHDYLWCITSGEPCLKINCPGDTHPERTNAEPPENPEKASASGIVIDDKPDQNYLLKYENTKTLDKTQSSDASDDEVAVNSTTAQDEELTNHIMAQEELIALVQALIITLIKLITMAQEMLIAKMHQVFISMEQQVLITKMQKNLINESQESLILNAKRQDAPSEHHGTSSSDHQNARNLEQQDSLNPEDKFDEDEQLSRALKESLEEAESMAQLKHREDDQVVIAMQKSVQDEIERRQSSKKGKLKHKASSSKRPTNNNSEDDDLVLQKAIQASLSDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H797</accession>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchoidea</taxon>
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            <taxon>Heteroderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H797"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1436.t1">
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        <property type="gene ID" value="Gr19_v10_g1436"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1436.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11113" checksum="782D4A005FD66E66" modified="2023-02-22" version="1">MTETNSAQIAAEQESSSTSLNNAVRELQVIRARILELEDQQQTTNSTTLNTVLQRDRFAVFVPERRRRLNFTFPNWTVYASLTRHAPVQSLFLIFQ</sequence>
</entry>
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    <accession>A0A914H7F7</accession>
    <name>A0A914H7F7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7F7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13917.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13917.t2"/>
        <property type="gene ID" value="Gr19_v10_g13917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="410"/>
        </location>
    </feature>
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        <location>
            <begin position="439"/>
            <end position="534"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13917.t2"/>
        </source>
    </evidence>
    <sequence length="590" mass="67462" checksum="5F1268B2A6304B7A" modified="2023-02-22" version="1">MQSFENDFSLYNTNNEQQPKKRYSDREVLFIPPWETKIGQLQQVVRTIQRNSDAVLDNRGAVIVRCYPYRSGTYMHLVYNLIYATLASNAQFGPAQSPNEIRPILLNYNTQQSASNPSVVGPQAAAFTSGVLHFGQQQQWTDFVLIRVHFSSHEPAMCFMQSFNRSVVRVFDRRQMRMPFCHADLTRPERVLRNHLQQLCDEKNSGANNRAPTQQQYRGRFFSFAPRYYHNGFQMYKDFSSGRVELVPWEQFSESQYLHVLVASLRKFAAMYKQKECFVIIQNVAEHTGSSEADMERITSVVYSIVSTEAYRQRCIHIKQKLEMFKNAATGTFADQQQHAYATAGAPPFSHASNHLPQRIERLPRRTGGASRATTAQQNGQQKKGVGEAQKQQKEGHSAGGEGKETMATRPPLIRVQFRVREAAIAFCQMFKEHQMVLQQKRREQQQMSGKDNDEGATQQNAKGNDCDVEDQTDSYSDLSDLDVFSSSEGGDEAADHHQQQRKKNAHEDGGGVKATGEEKKKKKRPNHRQQQQHSLDTFITAAFAHRDLTPPELALGYALRQHCREQNDTANKRYYVFPRAGRVFERLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8B8</accession>
    <name>A0A914H8B8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8B8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1515.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1515.t1"/>
        <property type="gene ID" value="Gr19_v10_g1515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037081059" evidence="3">
        <location>
            <begin position="30"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1515.t1"/>
        </source>
    </evidence>
    <sequence length="509" mass="55968" checksum="89250A4651DE10B5" modified="2023-02-22" version="1">MAKWHKTPHPSSCKCIIVLLIVLKSTVLASSKADRPSTEFIVQLELGIDRSEEVGANVGQIARRLEMICAMAFWRAMKAHLFGRGQIVRRNDAGGEKTKSAMSANEGERSGAVTLFPFRVQVIGLSSSTTPSARPLRLFFSASLNGKMVPAKSLFADLSLLSLPEMSALLQIPIVGISALAQLEVAERAQWWVVALITGGGILLIGCAWTLLVLYFNLCVVRRSTTERTVMEKGTEGEKEEEMKKRIEGRKGVEGEGGRGRKMEEEKEEQMKKRIEGRKGVEGEGGRGREMEGEKEEQMKKRIEGRKGDDGEGGRGGARKGKGGAEGGIRSRENERKMMTNSNRSRSWRRRKKKTLRWPKVVGVWRRMNDGNRLTIRGKMHGVESEATDVGGSSTSGSAAEQKTSTRTTEVNGGGGDESHPPAMGRHQRKEKRPIDVENVPAQWKLAISNGGAMATTGRSPNGLRPRPRPYWVADQLENIYHLFQSPSAHPRPGPRTQNGEIRAGAIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8Y4</accession>
    <name>A0A914H8Y4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8Y4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14340.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14340.t1"/>
        <property type="gene ID" value="Gr19_v10_g14340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="253"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14340.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49710" checksum="DFF5D1AF0068302B" modified="2023-02-22" version="1">MPKPNSVVGRMKHLLDTGNGADVHFLLLAAHSQILMSASDVFEAMFPFDARNADPSEGTKPVEVPDVEVGAFKAMLSFIYADDLSGLNGDNAIAVLYAAKKYDLPELVDSCLNFPISKLSNVFFAFAQTRFLGEEHIDQNAGALLLSEEFLQIDQKLLCEILDRDELMINEEIAIWNAALRWAVEKCRQNGKEPSATNRRAMLGPALFKIRFPLISQDDFSGNIVPSGVLTEGEKLSIVLYYLCPDRAMPKLYPLQFPTNGRAVTKLGLTLQNRWDSAACHDDLTLIGPARLDVQFIGEKREWCSVLAELPIPKSGIFYYEVKIIWKGDNVSIGLATKQMPLDLWVGENEGTYACDNWGIFWGHEVEGCSHFNGRPYIEGKPKFGGGDVIGCGVNLATRQIIYTKNGQRLETTGLLVDSDADLFPCVTLYNSGDEIEANFGPNFEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9T1</accession>
    <name>A0A914H9T1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="21">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A914H9T1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15120.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15120.t1"/>
        <property type="gene ID" value="Gr19_v10_g15120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000010">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15120.t1"/>
        </source>
    </evidence>
    <sequence length="600" mass="68381" checksum="0B1128027E6944D8" modified="2023-02-22" version="1">MPQFAHLLRSSDTDAQTQQLPFIVRTSSRSSMGNNLLSRIAQFFSRRRGLYALIIVLLVLSLLYIQFFAFPSELQHMDEAISLKNRRFLHPPKAAGGRTGDEPHHQLQDSGEFHPRKQVVAPKLTTFEGPSNARQAAVRDAFLYAWNAYKKYAWGHDQLMPVSHSYQEWMECGLTIVDSLDTLLIMNLRDEFADAMRWVERELRFDRNRFVSLFETTIRVLGGLLSAYHLSGEQILLTKAEDIGQRLFPAISQSPTAVPYSDVNLHSGTYRQPTWNVDSTLSEIASIQLEFRDLARLTGNSTYEQLSFRVSENIHESACVQTGGNGLCGMFLSPQTGQFKDSGTITFGARADSYYEYLLKQWLQTGKTVDWLIDDYKKAMESMRTQLWRRSTPNSLHFVGELTANGQFSPKMDHLACFLAGTLALGTQHGMPSVHMEMARNLSATCHAMYANPTGLGPEIAWFNVDGAVLTQLSDEKVGERKAAPDLYIKPLDAHSLLRPEAFEAWFYMYRLTGDKQYQDWGWDAFQAIEQYAKRPNGDGYASVQNVKRIPVQHRDLMESFFLAESLKYLYLLLADDQQMLPLDRWVFNTEAHPLPIRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9W2</accession>
    <name>A0A914H9W2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9W2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1514.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1514.t1"/>
        <property type="gene ID" value="Gr19_v10_g1514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037862162" evidence="1">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1514.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13018" checksum="48284265035C56F2" modified="2023-02-22" version="1">MFAPSPVFVSMLVAMLFLSMALPPSSVSAAPFDQFSSVVPATYVIEEPSPPILSPYPKSLTQSLQSPLQLYALQRRSLPQAYANRRSAHPCRWKLCGAYHNYSSLRRFLNLENNGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9Y8</accession>
    <name>A0A914H9Y8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9Y8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15410.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15410.t2"/>
        <property type="gene ID" value="Gr19_v10_g15410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15410.t2"/>
        </source>
    </evidence>
    <sequence length="227" mass="25887" checksum="6CA90158E18027A0" modified="2023-02-22" version="1">MFNICPSFKALFTCAAILFMLTIIELHGLKCKRARKAEWANDTESLDSLCPYRKGTEERCYVLNCSDGNSHRADWGCVADFGDAHFQCPASCFNANSFACKCLLGAAGVDMSNENMNILNGRTFEKALPYDDDNNNEYNYNYYNYNDFYNYDAFDYEFHCDHDDFHSDYADIGCSVNVYGHGCDSQQLPYQNGPYRLPSCLHDFTCAVPLTLKRWAYDEENVTKTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAD2</accession>
    <name>A0A914HAD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15261.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15261.t1"/>
        <property type="gene ID" value="Gr19_v10_g15261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15261.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21586" checksum="2E3C59D5ADA90474" modified="2023-02-22" version="1">MTASAAETSTHEKILEAIQKGELQTEGEDAIADGEDVGEAEDDESHSEAGSDDFIDSVFSQQHIVKADDELEPAIPEQPTADDTSMETDEAQRINSPQHRTTAAGLTRQNAAQLRGMVIAELAAQGEKFERTLQVERNTRDRERRDQQAENARLQAQFLRCLLAHFCFIVHVSVARKCVLQPFMELARALRIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBH0</accession>
    <name>A0A914HBH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15064.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15064.t1"/>
        <property type="gene ID" value="Gr19_v10_g15064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15064.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11013" checksum="B26B94BB18ECB55F" modified="2023-02-22" version="1">MDKAESVKLELKTFDEIFGEGWWDKDEAEDLKTPAPTNFGQNVHHQIDRQNTQIGQIESNSTDQNPPLTESDHSDNAKNGDEQKKMSGNVKLSPNSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBI5</accession>
    <name>A0A914HBI5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBI5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15991.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15991.t1"/>
        <property type="gene ID" value="Gr19_v10_g15991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037340537" evidence="2">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15991.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14522" checksum="41D37C72B05199B5" modified="2023-02-22" version="1">MFEQFNKNFLFLASILAMLIIEIKMDAPKGNVAKPGGAEPRGLLLLLGGQKTSANGIGKENKQPKSQSKGTALRGGRHKRDVLGNAGGNVGGWDHPIDSSYDYVDTMFKEANWLADKVKKYGWENYGVPAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCR5</accession>
    <name>A0A914HCR5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCR5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15411.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15411.t2"/>
        <property type="gene ID" value="Gr19_v10_g15411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15411.t2"/>
        </source>
    </evidence>
    <sequence length="99" mass="11480" checksum="C01A866CB6BA4F0B" modified="2023-02-22" version="1">MSDNPSKVKKQMKEILTFCWTRISKQKNVERRLPIPQKPLPDKVIGFERLDISYIDRSAIEFLQNICRLFDSKGANLFIETAGNQKRSWQILAPDLASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDE2</accession>
    <name>A0A914HDE2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyprotein allergen nematode domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDE2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16324.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16324.t1"/>
        <property type="gene ID" value="Gr19_v10_g16324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.30">
        <property type="entry name" value="Nematode polyprotein allergen ABA-1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032487">
        <property type="entry name" value="ABA-1_nematode"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038289">
        <property type="entry name" value="DVA-1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16469">
        <property type="entry name" value="NPA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038114844" evidence="2">
        <location>
            <begin position="28"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="3">
        <location>
            <begin position="71"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="3">
        <location>
            <begin position="214"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="3">
        <location>
            <begin position="357"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="3">
        <location>
            <begin position="500"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="3">
        <location>
            <begin position="675"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="3">
        <location>
            <begin position="748"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16324.t1"/>
        </source>
    </evidence>
    <sequence length="876" mass="101193" checksum="453FA0B69025E9ED" modified="2023-02-22" version="1">MSSKKAFSIHCPLLLIVLLTLPPLATASGHQFSLFSAVKDSHNVRRDVREADDASSSSINAEEDLGGLNTGWLTDDQLSELTSAEDNEERMKKLRGFYDNLEGEAKKGATEKLIVDCYGWLDDVASEDERNALKQMHHRNHEACREKVKELLGRLGEERREQVEKRLGFCEHVWYDGKMDGEEGRSAQTGDEHHHHHGKRWIHRRRRDHQHGDHRVEDYFKTHLAWLTDDQKDELGRMKETGKSRSELKQKVIEWYDATAGDVRERATELLKGGCRELIKMVLGEEKSNKIKEMKESGTDVAKIGDQINAWIEEVTDAKKKELATEYRGICAKLFGVKSSRKRRDHQHQHGSHEGHHRVEDYFKTHLAWLTDDQKDELGRMKETGKSRSELKQKVIEWYDATAGDVRERATELLKGGCRELIKMVLGEEKSNKIKEMKESGTDVAKIGDQINAWIEEVTDAKKKELATEYRGICAKLFGVKSSRKRRDHQHQHGSHEGHHRVEDYFKTHLAWLTDDQKDELGRMKETGKSRSELKQKVIEWYDATAGDVRERATELLKGGCRELIKMVLGEEKSNKIKEMKESGTDVAKIGDQINAWIEEVTDAKKKELATEYRGICAKLFGVKGESGARRRRSWHGRHHNVQQKNRPKEDEGEVQLEDEDEGRTEEAYDMEGEHLSHHNSWLNRKQKQTLKRLRDRGHEDHELHERIHEFYDVSPEEVKATARGILQRGCESILKERRRRSAGHAEHSLEELFKSYLSWLSEHQREKLKGMKGSGKGRTEMQQKVMEWFGQLQGEQKTKAREHLRNGCRELLAHVVGNENANQLKQLREDGMSRTELEAKANEMVGAVQEEEKKMEAKEFGAVCKKLLLEETENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEC1</accession>
    <name>A0A914HEC1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g15836.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15836.t1"/>
        <property type="gene ID" value="Gr19_v10_g15836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043461">
        <property type="term" value="P:proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DEP" evidence="7">
        <location>
            <begin position="1338"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="884"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1683"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1694"/>
            <end position="1708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15836.t1"/>
        </source>
    </evidence>
    <sequence length="1735" mass="197775" checksum="172AECFFC3A82395" modified="2023-02-22" version="1">MLRFLRPHITNRRLLSSGALPASALKKPSRFYKEVEVRELDACGTGGRPPSEEKSFGIFLDGRQLRTPLGKQFNVSEPLALAVAQEWSAQKDVVRMDTMHFTGLAFTAFDNPCEETNDSLVNKLLAFLQTDTILYFADPSNTLSDEQRQYWSPVIQFVNLRFGLSLSPVENAFIQLELSQNTREDMERHLLGLPNAFPSLIGILYGAEAVKSLLIVLATLEQYLDVDTAVRLSLLEQIHQTKVWGTVEWAHDAEHNDQCARLAAAVLFTRWMNDDGYIRCKLIHRAEEGFELCPRLIPNLVPGDIIQICSVHSRDCVVFQFTSECINESRFKDRSIVVCSKAFEHRKTQFPTRSDVLVRRVEKSEVALDNIELTFKVLYKEYYISRADMWRFRNCLIDSCVYVGKKEEWLGILCTVSDLWRAGESAWSGYVSEETRVVFRSSSSQVLIYIQFGEEMWDIDPKGDLYFEKCVKGFLPALFRKWKEQFCAHLVTIIVFSRWYYKTEFLDEDMKERMKNSRDHRDRYYQDFYWLLVQNEHYGDWTHVLSKLKLTFYNYKSSIEKYNRETFPTYSAEKPICELSTASDGNFLEVLNISMNSFLAYHSDRRFETTGQQIIFLTPGGGVFNVDREMVNLTKQRIIDMGISLDIVCLGEQPLHAVPLFVFNHKSQETEDYFIPHWMNYSYFNMPRRSTISSKFKTRINFPEDIVKNTDEGLFLEKSIEEVEDHRLYDENSFFSFNQTNFGAASNALNELYKELMVSNGPQCAELYGRSSIPLATSERPIVGSLECQGNFLERSRLGSTAGRGGSLESKPLMVNGQRVPGQSGPYFEPIQRGFVNPFRPEQFIVRITANRRRWIHVFPVDRLGRAKLAHHYVVGSSTMSVLSTVEPEPLPPQSTHQSISDASPARRAPSPLNPSSEGTAYSENKVTGLGAKGRTMVWAWGSTGEEKWNPDMEIGCDWKSLVRSGLLPITTDFFPDGRSLNDYTMSEHHVYLEFDEMRKWVPPEHFPKPTTLHLCNLLFDQLICQRLQRGYQIVVLPKEYIHSAIRKIICDRARQPVHREICLSFNHIYHRISLIIDCTESVPHNTDATILVQQFIPKSMVNLEMRNPTQSNKYNYLFQVPDDVRYMASTTCFKHHNLDRLNWSRLDSELQNAARCPQLFTEEMKCFSSRWLALPDTSKIAKEVLSHRRGDIYGSQLTSAEDLECNFMRFIECVNRVRSNSSAHAHCQRNFSGGNATGAVIGCAAAGTAPAAATAGGSRPETPLKLVADAVNCCPLNFQTSFSSVENPSPSATATTSVLSLNELLASEPDIILGAWMVQMELNPISLPPKNTQTLPPSVFISYDFICWLMRSVLGLNVLEEAVSFANRLLVEDRIRLLAPPTDSEAYDVDASNKVSTNSGEHRFHYGFFLYCVVSDSVEADFARVDLRGKIYISIEKPCARHSVNRECRFRPKGVSMEFATSSSFAIRNLENQYVEWGRVIFHRAYTHSQAFEFYIKWFMATGQTVADLVHKQWGRHAQKYSVHFFPVPEDAFAEPTNVLSSPLRCPIFVTFRVDLIPEVQFDCVLSKIMASFGFVLMGCPVHRDTPSSSGSIPPQTQQHSPELARFQQFVHLSGGMFVKFDPNQRAFMWAWNHMLSQRFRSSWCSEEFLDFMLSEFRAFCRNDNERLTNFVSMSCADSVGQGKSGGNVGVEPSQQQHADDNGTSPTAGDGLMNETEESVGAQRSDAIHLPIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEZ7</accession>
    <name>A0A914HEZ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEZ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16003.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16003.t1"/>
        <property type="gene ID" value="Gr19_v10_g16003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16003.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27940" checksum="4AFEF38C192CDCF3" modified="2023-02-22" version="1">MSDNPKNAEKQLKAIFICDDLLFEVFKFCGHFVLGLKVALIGDRFDFLVDAHFKSMEWTLGQLEVRRATEGNGAEIVKRFGEEVERLLPIPQKALPDKVIGFRVLRISYIDQNVIKFLQNIRRLFDSKGTYLYIGTDEDENRSWEIIWHRIWPLIKDNIYGLDLYTFQLDGWRQFSPTVLNDCPKLRLIHCDTIFPAFPADDSAGASSAQAWLNGCVRRAEMAFRRCWKSIIFIRKWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF18</accession>
    <name>A0A914HF18_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HF18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16769.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16769.t1"/>
        <property type="gene ID" value="Gr19_v10_g16769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11367">
        <property type="entry name" value="RNase_PH_RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16769.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="34803" checksum="A6775564677E01EA" modified="2023-02-22" version="1">MEVLISNHEKNFIIDGVQEGVRNDGRSAKDYRPLSLETGVLVGSNGSARLQLGDTDVLVAVKADLTLVERAELVDTQRLRFFVDISANASPKFSGRGGNDQAEEWAKALASAFGNASPSAIPDMAKLVLAPTQLWCLYVDVVVLQFDGNAMDAISLGVKAALADTEICNVVVRPADEGKVHIDMPDEISTWHIDMTEAPLVIGVNKIGDQCVLDADLMEEMCSSSTLYVGVQPPPPPSTDPTKSDKKQHSVNDDGDDASQMAMVTLLKKVRGGSLEVDSVDEMIARAAEAAVALNRALLARLKQLEAKKCSAPEAPRRAALFGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF19</accession>
    <name>A0A914HF19_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF19"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16916.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16916.t1"/>
        <property type="gene ID" value="Gr19_v10_g16916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16916.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9771" checksum="F4D95F23F4A2408E" modified="2023-02-22" version="1">MELVFDPSLVAQCRGYGQCADWWSFGVIAFELLTGCSPFTVDGNQNSTEDIARRILTKKVPYPKWMDRTSRDFIGQLLNRDPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFR7</accession>
    <name>A0A914HFR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-gulonolactone oxidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g16750.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16750.t1"/>
        <property type="gene ID" value="Gr19_v10_g16750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037885308" evidence="7">
        <location>
            <begin position="24"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="726"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1297"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1301"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16750.t1"/>
        </source>
    </evidence>
    <sequence length="1326" mass="147811" checksum="DCE4DF4B34494E8D" modified="2023-02-22" version="1">MEKLLSFLLLCFTALAFTDVINSECPAVKGFVGECFDREDANDRNYEKWCYQYASTSMNYTQMRPKLILVATSVKDVQAAVNYARQKRVNIAVRTGGHQYSGASSASGNNIQLDLSEAFKDPDVDFKVDQKAGTVRVGVSFTLWNLYSMLNANGLFVPAGVCSNVHVGGHVQTGGYGVAIRAFGLFGDYVVGLDMVTADGKALHVQPDSQNKTIRDLFYAVLGGSPGNFAVLTHVTIKPIQDKDHPNSVGFRAAYLYTKKSLLDILHFMTQTSELDRDYDIMVTLVSGNKTFPGPAPLPSVISISAQWSNIDGHNQKVDDDVIGFFKRIEAALQDTKRIPIPELDMEWNVHTPLSNMSLKNAFPGVREFVMPYDKRLHLSDWNTAKLQKRLWSNWTADRLDEFLTARNKVLDPTNPAASFELFSQLQNAGGSKSAFYRNSLRKNPVDGRDLVSYSWRDATIIASFDAWYNTTEDPDAQQFVANWQEETMTGALGPRGHNTDLPPDKAPKLFWESFGDRNMGNVWHQYHPKAQYKRLVVIKRAVDPTPVFTPNNFTVGVPKGKPDLPSPAPVLLPEGNFPITIDLISTSGAGAVDAYMVGWMQAKNSRDSKLVNVRLPSQQQQQRQQQKHPLLSLLNGLVPTKALQFGERRRTVARRHRCRRHSTTMEKLLSFLLLCFTVLAFTDVINSECPAVKGFVGECFDREDANDRNYEKWCYQYASTSMNYTRMRPKLILVATSVKDVQAAVNYARQKRVNIAVRSGGHQYSGASSASGNNIQLDLSEAFKDPVNDFVVKRSAKNGVTVRVGISFTLWNLYSMLAKEGLFIPGGLCSNVHVGGHVQTGGYGVAIRGFGLFADYVTGLDMVTADGKALHVQPDSQNKTIRDLFYAVLGGSPGNFAVLTHITIKPIQDKDHPNSVGYRATYLYSKKSLLDILHFVTQTAELDRDYDIMVTLLSGNKTYPGPVPLPSVISISAQWSNIGGQYQKVDDDVTGFFKRIEAAFEGIRRISTPQDMEWTVHTPLSNMPLKYAFPSMREFIMPYEKRLYLSDWNTATLQKRLWSNWTADRLDEFLTARNNVSSSSSCSQQNGPPGSGMTVVVDSNPLKRAGRFEIFSQLQNAGGSKSMFYRNSLRKNPVDRRDLVSYSWRSMTVGGSFDAWYNTTEDPGAQQFVEQWQENTMKGALGPRGHYTDLPPNKAYKLFWETYGDRNMGNVWQQYHPEAQYKRLVGIKRAVDPTPVFTPNNFTVGVPKGKPDLPSPAPVLLPEENFPITIDLINNSGASAVDAYMLGWMQAKNDRDSKEVSSASPDVAAAAEPTEPVAGCKMRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHD9</accession>
    <name>A0A914HHD9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HHD9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17522.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17522.t1"/>
        <property type="gene ID" value="Gr19_v10_g17522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05917">
        <property type="entry name" value="FACL_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="110"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="555"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17522.t1"/>
        </source>
    </evidence>
    <sequence length="657" mass="73046" checksum="C33114F15D80DDC0" modified="2023-02-22" version="1">MIRLFSARPSAPSASSPFSLLLLSRRGAAASALVPSSLGALLFAKPSPHSPRLLVTVVRNTNTASEASSTYCPPPTEAMNIHSLADQAKSYVHGCSEQPLLFETIAERLRMAARKFPSREFVIFKREEIRKNYRDVLADSERLAAGLVHLGMEKGDRLGIWAPNKYEWITAQFASALGGFVLVNVNPMYHSEDLCYAIEKVGIKTLIAPPTFKRTDYYGILRELIPELEGAPRGDGRLCTDAFPKLRNLVIFDAEKRTFNGAWSYDAVMGMGTADDRRKLEQYEASTQPDDPCNIQYTSGTTGKPKGATLTHHNILNNAFFVGLRAGYADHRTLICIPNPLYHCFGCVMGSLAALVHFQTCVFPAPSFEPLAALQAIHEERCTAVYGTPTMYIDMMSHAEYPNFDYSSVRSGIVAGAPCPVTLCSRLVNELGMKDLQVCYGTTETSPVSFMSILDDPPEERIRNVGHIMAHLEAVIVDKEGRVTPRGQRGDLLVRGYSVMYGYWDSTIHSSSDVAKDRWYRTGDIGVMHPSGTVSIVGRSKDMIVRGGENVYPTEVEQFIDRHPAVADVHVIGVPDNRYGETICAWIRLKNDATVSGEEIREYCKGKIAHYKIPKYILFKDVSDFPMTVTGKIKKFEMREISLRELGLEKVRSHYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ29</accession>
    <name>A0A914HJ29_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ29"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1763.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1763.t1"/>
        <property type="gene ID" value="Gr19_v10_g1763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1763.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8679" checksum="61A93B447560577F" modified="2023-02-22" version="1">MENGVVAPFCNLLGASDGEITLKVLNGLKRALNNAQKREKVIELIEKCGGLRKIKQLKTKESKLVLKMIEKQQSSKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK38</accession>
    <name>A0A914HK38_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK38"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1855.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1855.t1"/>
        <property type="gene ID" value="Gr19_v10_g1855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1855.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19917" checksum="46BB40D87183987B" modified="2023-02-22" version="1">MIVVSKIPKEPRASMRPFTRAARLLKLIPPERALLVADLQEKFREQIKYFQQTVQATWCLIEEAKLRDFYWTTVVFKQSLRIGGRLVKYQILFAVAESQHVLLDLARRTYHDWLPKSVVSAFHRPLVVLPSSSGRRRNRVIAPEAQQQRVTHGIQQQRRDATASVPMPSIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN74</accession>
    <name>A0A914HN74_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HN74"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2858.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2858.t1"/>
        <property type="gene ID" value="Gr19_v10_g2858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2858.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31473" checksum="EF31634DCB66EC80" modified="2023-02-22" version="1">MSQQQQQRHFTSTPFFVKASSRPKFQSNRRRFCTPYQPRDSTAPVFVGQEFDDGMNVVERPSRNCTLGRESSISEGLLEVAAEVEVKVVEAEGTEEGTHANSNPQIPQQRQQQKLLPATSNGSSHHQRHLGAVSSVSSVTIDEQPSAGISRHFLRRSLRTNSGTPSISSIQQLLRFDSNQCFDIEEFRVRMAAAQQKIEDLCSLNLNNVKLKHENGQLREDLDSCERRISLLESSVLERNERLKELLRENVFMRAQFKKIQNEFGVQAVKEVFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNI9</accession>
    <name>A0A914HNI9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HNI9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g316.t1">
        <property type="protein sequence ID" value="Gr19_v10_g316.t1"/>
        <property type="gene ID" value="Gr19_v10_g316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF62">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037678578" evidence="9">
        <location>
            <begin position="21"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g316.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="30883" checksum="03657801E39CA8F0" modified="2023-02-22" version="1">MNTPKFVLLLLGFSLYYKLGDNVHAASGNGQQQHEAGGQCDKNSETDFDCGDGELRTRCIASFWHCDQVFDCSTGKDELDCLYLHKCPAGHIACRNGDCFLATSRCDGHKDCDDGWDERGCNEAKRSTAESSLNTVEKIHNRPADEEEHENGLDIMDAEAMVDESDRETNSTAFFLLFSTLLFIAVSLVCLAIFRRYPNTVSRLDRTLKEFNQSISSSARTLLNDGRASPVHSHVTIATSANNNNDHQFFDNPLHLQNPLVLGVHSTAPRSTIGQPPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNS6</accession>
    <name>A0A914HNS6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNS6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3235.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3235.t1"/>
        <property type="gene ID" value="Gr19_v10_g3235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3235.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="24794" checksum="D738226FE8173DF3" modified="2023-02-22" version="1">MPNHPNPRGTSIAVTMILAHLKLSPGTPMPSSGPPAFPAIPPATDNAMDIDSVSIGSPLSNAPNPEDNIPADGQTADFRPAPDRTRTDSSTDDSHPRIRGPSPANPPHPPTEPQAPSPVHAPSIEVVIGNRGPATNARPAPPRPRRPRRRPFRGPLVSRVRVLSSGAVLSLPPRGPTHRRGNPTRPLYALNPRGPTPLNAIRFPQGHPATSSSLDFPLDVPTCFAIGGVSRPRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNU4</accession>
    <name>A0A914HNU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3016.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3016.t1"/>
        <property type="gene ID" value="Gr19_v10_g3016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3016.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11057" checksum="0DB5D99E5868996C" modified="2023-02-22" version="1">MIGELNTAVDKLFHVVEHFPGKKLLVMFKRIVRFFKVDWFIGYDDLKAFDHYTFAMFCVQIDKIQQGVSTHCDSAIDDAAAYFDLSADEHDENLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP91</accession>
    <name>A0A914HP91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2964.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2964.t1"/>
        <property type="gene ID" value="Gr19_v10_g2964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="259"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2964.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="51286" checksum="636F981D26B62730" modified="2023-02-22" version="1">MPKPNSLVGRIKHLLDTGNGADVHFLLLPAHKAILMAASDVFEAMFPFDARNAKAAAAGKDPSEETKAVEVPDVELGAFKAMLSFIYADDVSGLNGDNAIAVLYAAKKYNLPELVDLCLNFPIWKLSNVFFAFDETRFLGEKHIDVNAGALILSEAFLQIDQKLLCEILDRDELMISEEIAIWNAALRWADEKCRQNGKKCSAANRREMLGPALFKIRFPLIPQKDFTQNIVPSGVLTLNQMMSVYVHHSHPDAAGLPELYPLQFPTNGRAFTGLPLQNRWDSAACHDKLTLSKPDRLVVQFTGENEGFCSVFATQPIPKEDLGIFYYEVTITEHYEIYIGLATKQMPLGGWVGRYKGTYAYDNWGSLWGHTVEGCFRLFNDKRPLIKGKPTFMEGDVIGCGVDLATRQIIYTKNGQRLETAGLRVDFSADLFPCVTLFNPGTKVEANFGPNFKFNIADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPC1</accession>
    <name>A0A914HPC1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB/POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPC1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2462.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2462.t1"/>
        <property type="gene ID" value="Gr19_v10_g2462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="322"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2462.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="54108" checksum="844301D7738C713A" modified="2023-02-22" version="1">MQQKHHHSNVIVGMNHAQQNIVPKANSSLERMKHLLVTGDRADVYFLVGEGDEKELLPAHKAILEKASDVFEAMFRFDEENAKAAAAETAPPAEEIKPVVITDVKVDAFKAMLAFIYADDLSGLNGNNAISVLQAANKYNLPGLVKACVAFPTPELRNVFVALAEARFLGEKNYLNYQFLLFWDFARRCLDYIDENAATLIPSKAFLQIDQQLLCEILDRDQLRVSEIAIWNAALGWADEKCRQNGEECSAENRLKMLGPAFFKIRFPLIPQKDFIDNIVSCGLLTSDELDSILQHYVHPNSVLLERYPLQFPTKQRSMPVKGTILLKIEKVSEFAREDGTKRRYSEPIYIRGLPWKIVTYSTVSEQKYLAFFLQCNGENTDANWSCAVSATLRIVSQKEGKTDHTRGSKRLIYNSKKKSWGLSLFISFEKLMDRNNGLYDEENDTVILEVEMTAEEPEVPLLSKIWRRFGKGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPU9</accession>
    <name>A0A914HPU9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPU9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3336.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3336.t1"/>
        <property type="gene ID" value="Gr19_v10_g3336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037226679" evidence="2">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3336.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15351" checksum="4A30ED3B68A1589A" modified="2023-02-22" version="1">MEKFWILILVAFFATNSLDKAESVQLIDEIFGEGWWDKGEAEDLKMPAPVHHQIDRQNTQIGQIEPNSTDQNPPLTESDQLGQIELNSTDQNPPLTEILLSQSLITLDKLNPIQLIRIFPTQSLITQKMPKMAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ45</accession>
    <name>A0A914HQ45_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ45"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3412.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3412.t1"/>
        <property type="gene ID" value="Gr19_v10_g3412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3412.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="27184" checksum="448D2247DB50B47A" modified="2023-02-22" version="1">MSLFATNLLDKAESVKLELKTFDEIFGEGWWDKGEAEDLKMPAPTNFGQNVHHQIDRQNTQILQIEPNIAENERKRKIINKFHAMKDEFKQKGNYSTKEWEKFYQRKAELKRAGFKNSYKQEIDETVAKELGLSLATIYRWKKELGQSKPQHSHSEQKELIKRYYKIKDKNSKISDEGISKMLKIGIRTLYKWKKLFIRHQFHPNSVDGHSVEVNVSQINVQEIGNTNSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQM3</accession>
    <name>A0A914HQM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2998.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2998.t1"/>
        <property type="gene ID" value="Gr19_v10_g2998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2998.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8914" checksum="446627E882483D54" modified="2023-02-22" version="1">MKNIFAFLVKTWPPVRRPTTRKKCLHKPPLLSCQKQNSQRFGILHCLITSPKLFHYEPAHGLQQSTASRRCQCHCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRI1</accession>
    <name>A0A914HRI1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRI1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3048.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3048.t1"/>
        <property type="gene ID" value="Gr19_v10_g3048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3048.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23701" checksum="80E6D279546F26FA" modified="2023-02-22" version="1">MPRVCCCCPTESTPIALAASENCTKNGRNANIFLSLKQNRWDSTACHDRLALSEPEKLIVQHNEDNWVWGSVRAEKPVSKNPYFEVKILKAPNHILIGLATKQMALDIHVGGHESSYGYTSWGVFLGHEVEGCGHYNGSPFIKEKPKFGVGDVVGCGVNLATSQIIYTKNGEQLNTANLLVSFAVDLFPCVSMLNPGTKIEANFGPNFQFNISDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRI8</accession>
    <name>A0A914HRI8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase A2</fullName>
            <ecNumber evidence="1">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HRI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3571.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3571.t1"/>
        <property type="gene ID" value="Gr19_v10_g3571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="10">
        <location>
            <begin position="611"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="615"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="647"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="777"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="649"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3571.t1"/>
        </source>
    </evidence>
    <sequence length="988" mass="111409" checksum="619682C6490DA436" modified="2023-02-22" version="1">MATDAKDDELKENIVVDVKNTTEENDSEPEENETQETESESGQQNPGDGRSRFFSLTQVSVKINELWSTAKERVFGEDYWIPSDPFEVVDFRPDLLASHKIVYPEDTGGSLPSLVVVQGSIKNEQSMALNHVVYTVEGESGQKRTFTIFRSQNLEEALDICRRYEECRVLFRSSDQKKDMRKLIWDVTFVMKEHPLWRMAHIAILCQRVDIFTDDGLAYLQQFEYSVNDVVHVACSPEGIYPLMLAIQTNQESIVRFLLKHGADLSARDPVGNNAIHYAALVSSQMLETLLEHEAAKALINSRNNVGETPSMVALRAVNPLCMKTLFNFGGELLYKSTDKNLLFELIQSNKGNTPDAIRVLLEKSPSLLNERDITNGNTCLHAANQKTSLMSLLHLKHKEMDLNAKNKAGFTPLHQFVIREDIGMVMCLLSYGAGLDERADSGKMTALHFAVSKRNLQITRFLLCLGADPNLANAHGDTPRHLAAKLNEVELLKSLIICEARRCPLTKVGCVSGCVNEKALHKLKNPSSIPAMALPSSSSSNTTTKNSAAGGGYTSVMLEDFEKRKFDKEEYRFNKLLDLEHNAIYDEIFKKLTDLGTEGNAVDHNFINVLSLDGGGIRGLVILQILVCIERILREPIFPYFDWVAGTSTGALISAGLTMGQSLREIQRLYLRFKDLVFDNRRPHNTRVLELFIRNELGSETKFSDLKCPMILFTTTRADFFPVQLELMRNYKLPTNDEENEELGYTTPEDLLLWKVLRRTSAAPTYFASVDNKYMDGGIIANNPTLELLQEVQFWNSFNRYKNLPNLVNIGCVLSIGTGAIPPSPLEPTYLEFAQNWATQPITSFNVALTIGSILVDQVTATEGVPVLRAGSFCLQARAPFFRLSAPLFKNIEMDAKDDADTARMMWNCMEYMYKHRDYVEKLCALLKRVGHACHRRHMFKQFGAQTQHDQQTQTSRSSSPAAELLKMLNMDNIRNEQERKDDEGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSC6</accession>
    <name>A0A914HSC6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSC6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3308.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3308.t1"/>
        <property type="gene ID" value="Gr19_v10_g3308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3308.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26756" checksum="B955C95A09450E84" modified="2023-02-22" version="1">MNEFWILIFGSIIATNSLDKAETVKLELKTFDEIFGEGWWDKGEAAEDLKMPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQNLPLTESDHSYNAEDERKQKFDQMKAELTRAGFKNSYKKEIDKTVAKELGLSFGTICSWKSELGQIKPQNKYAHSEQKEMMKRYYEIKDQNPKISDKEIVKLLKIGTDTLVRWKRQFKRQKFLPNSVDGHSVEKNVAANVQEIGSSNLGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSM1</accession>
    <name>A0A914HSM1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSM1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3845.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3845.t1"/>
        <property type="gene ID" value="Gr19_v10_g3845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3845.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26013" checksum="FC22F6492BD7EA66" modified="2023-02-22" version="1">MGFPRTECGVNLATRQIIYTKDGKRLETTGLFVASAADLFPCVSPSDPGDKIVANFGPDFEYNNTTYELTLVTDQYGNYVIRLHASSLWSRISMATTMGFPMNESGVNLATRQIIYTKDGKRLETTGLFVASAADLFPCVSPSDPGDKIVANFGPDFEYNNTTYVLTLVTDQHGNYVISHMIEHGRPRDRTECGVNLATRQIIYTKDGKRLETTGLFVASAADLFPCISPSDPGDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSV2</accession>
    <name>A0A914HSV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSV2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4333.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4333.t1"/>
        <property type="gene ID" value="Gr19_v10_g4333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4333.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20118" checksum="C67C0F811C019CF7" modified="2023-02-22" version="1">MLTIIRLGRIVCLINPVELHTFLGMNGTALTNKKKCSSFDKSTLDPGPNNSINHPTSKKPFVSAQRRYDNVRVRDSEFLKRVCLDCGRVLIGAEKDYQEHLLSHESIQLLYQLDYFERFGASAPSRFLLSGATNHWTDQQQHKLHKPKTMEPIKKPQKRKQLLEASEEGSAKRNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT08</accession>
    <name>A0A914HT08_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT08"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4377.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4377.t1"/>
        <property type="gene ID" value="Gr19_v10_g4377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4377.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11094" checksum="BC56492B88A07A85" modified="2023-02-22" version="1">MAISFLIIGKKADFRSFSSSRLLSTSDQLATNGAKCSGGVISAAAVGLRQCLLPPDELLLNGQTRVFDKQQLVFVQVFYLPFTSGRSADDIGIVQHYLLKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT82</accession>
    <name>A0A914HT82_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 13">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 13"/>
    <dbReference type="AlphaFoldDB" id="A0A914HT82"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3547.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3547.t2"/>
        <property type="gene ID" value="Gr19_v10_g3547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="206"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3547.t2"/>
        </source>
    </evidence>
    <sequence length="564" mass="64798" checksum="FE7B84CF08F83414" modified="2023-02-22" version="1">MRGARQTAGAILRAGATGVRLIRESSQTPSDPNEYYRMRVEMIERRRADGDNPFPHKFDVSTSLHDFINKYDPILTEEGKVLEDEVVRVAGRIYLKREQGNKLIFYDLHGECKKIQILANAKFHEAGLDDFLLVHDRIKRGDILGVIGHPSRSKRGELSVIPTAVQLLTPCLRMLPRSHFGIKNIETRYRMRYLDLIVNPEVRDKFVTRAKIITFLRKYLDTLGFLEVETPMMNPVAGGATAKPFVTHHNSLDMKLYLRVAPELYHKMLIVGGIDRVYEIGRLFRNECIDQTHNPEFTSCEFYMAYADYEDLMGITEDLLSKMVFSIFGTYKLEFHPNGTDKEAVYHLDFSPPFKRLNIYDELERLLGVKLPEPDTLNTPEARDFFDRMATDHKIDCTPPRSCARLLDKLVGEFIEPNLISPTFLIGHPQIMSPLAKWHRSRPGLTERFELFACTKELCNAYTELNDPLRQRELFELQAKAREAGDDEAQPVDENFCTALEYGLPPTAGWGMGIDRLAMMLTDSHNIKEVLFFPAMRPFAEGQTGEEEEDGKDDQKQQNQQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTI0</accession>
    <name>A0A914HTI0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTI0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4524.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4524.t1"/>
        <property type="gene ID" value="Gr19_v10_g4524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858">
        <property type="entry name" value="OS05G0521000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4524.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16925" checksum="EA6B81A32DD4783C" modified="2023-02-22" version="1">MGIPQHLFLQYNEFSYDILSRTIEVEVNASTGQNEIRNSEPVEVGVNASTGQNEISNSEPVEVGVNASTGQNEVSTSSVQSGDVHGISPTNNHLPSTDSEEKFNLSPCAICFDKPREITFIPCGHLACCRQCADIIKNFCPMCRGKIEGKQLTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTZ1</accession>
    <name>A0A914HTZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4189.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4189.t1"/>
        <property type="gene ID" value="Gr19_v10_g4189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000008">
        <property type="entry name" value="Transcription factor TFIIA complex large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4189.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="49986" checksum="D6DC92D73021A7F6" modified="2023-02-22" version="1">MFKLGVAFMTSTEISGHGTHHLILMSQNYGIEDIYRGVISDVIIQVREAFLDEGVDVDVLQQLKKSWEAKMCSSGAVELDGHGGNNSSGSRSTQQQLVVHQQQVPPPALRQPPTTSAATRQHHPPRQPTTANFPAVSAANLSVGSHQLLLSGQQQMTGGHPCHSANAQVRLTPQQQTMAVAVAKQPQQLGTGVNLSSILQQTQQQQIQNAALIGLPAQLLASSVENSQLLQPNALRLMPGAQYAIMDGPGGAQNLILLATAASGQMNALAANIEQQHGQQHAMQFVGQPNVRSVQQRPTTVAMKTEPGGGQLPQLDGGRQWASSNKRNKAKTDGKANSRLELAQLDGGRGKAPPGMTDESSEEEEDREDEEDPTLSAIKYGLDEDHIDGEAEEEEEPLNSGDDQSDDEDLDTLFDADNVVVCQFEKVHRARNKWKFTLKDGMMQIRGKDFCFQKCTGEAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU36</accession>
    <name>A0A914HU36_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M41 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4689.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4689.t1"/>
        <property type="gene ID" value="Gr19_v10_g4689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M41" evidence="1">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4689.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15007" checksum="D07CDC3709D9A275" modified="2023-02-22" version="1">MARPNARQRAARLRARQEAEFKRLERLALAWDPAYNKCRVTIHETGHCFLLWNQRAAGVLESTTVVPAETTDGLTRSEWPWQLTRAQLTAMLRVQLGGRCAEEIAFGGVSMGHGTPEAGDEHKWRRTARAVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUB9</accession>
    <name>A0A914HUB9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HUB9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4263.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4263.t1"/>
        <property type="gene ID" value="Gr19_v10_g4263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="244"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4263.t1"/>
        </source>
    </evidence>
    <sequence length="828" mass="93698" checksum="C87AB082AFCA7811" modified="2023-02-22" version="1">MEELNKFALSAVECDRLGQTGEAIFYYKKAAHCTICLIESGKLSETYKQTVEKYLLRARLLMHNNGVNEAPDNSLSDVILTAQKMIDTALGQDELGEEAEAVQLYAETAEFCIEKSKLNDENSVKMRNLAFLALDRAETLKNKLAGKGTERLLFAGPSAPNLTDEDEDNNNTMCLLTLHSSDGPSPSNAGRIVANASPQPAGKTRRRWSEVRDSGSRKAVEKLEEGEVRVLFATSRINSRTYVPFIEESDLKEPFALSIPFSDKDGFLPLSEKQKKVLKGWLRPDEFMADPKVIVRIDSGTIKQTVITDCSFVASLAVCARFENRFGTRLITNIIYPQNKKGDPIHNPCGKYMVKLHINGIWRKVIIDDLLPLGNNGELLCSHSQNKNELWVSLLEKAYMKVMGGYDFPGSNSSIDLNALTGWIPERIPIRPKESAFDADKTFERLFLHFHQGHCLITLATGKIDEVERERTGLVDAHAYAVLDLRKVDGKRLFLLKNPWTNLRWKGRFSEKDVTSWTPEMCAKLDYNPKDAQQFDDGIFWIDYSSYLCLLRRVLCELESCPLPFRHALHSSWDAGKGPVKDLYTVGENPQYFLELNNRHGTASVWILLSRHITEKDDFANNCEYITVMVYKNDGKRVYLPFDPKPLLEGTRINSPHYLCQLIIREPGVQRFTLVIAQYEKMKTIYYSLRIYSSVEFRCGSIQVPYKFHKKETAEWRGPTAGGCGNGTSRETFQTGSDDNAILVELRGPREYSVGFEVALVCPIRIDRTFERRDSGPFRQVPGFTALQLEGLPAGTFSIRPMTFVAGQEGPFILRVDCSCNFQLKRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVM1</accession>
    <name>A0A914HVM1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVM1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4584.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4584.t1"/>
        <property type="gene ID" value="Gr19_v10_g4584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4584.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15589" checksum="B5907D38D21475A7" modified="2023-02-22" version="1">MASSSDNAEDKALWTCVFFDKISQTFFLMDVGHFVRLFSLAGPLSSELFPPIDLTFWWPHISKRRNGRRRLQIPQNPLPDKVIGFERLDIITSTKVSSNFCKAFADFSTIPKAQIFPSKQITTKTHVGKSFGTEFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW27</accession>
    <name>A0A914HW27_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HW27"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4544.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4544.t1"/>
        <property type="gene ID" value="Gr19_v10_g4544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="36"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4544.t1"/>
        </source>
    </evidence>
    <sequence length="498" mass="52858" checksum="86F272948FC2454D" modified="2023-02-22" version="1">MNSSNSYTTSKLSLLAVSVYFFTVTKSVLCLIGILLNLSLIYVTVRAKWLHGICNILLVLYDASLIPFLAGVPFYLIEIGTGVNSMQVYDCFRIQILPLFMFCASFPLMLCIATDRFIGVVFPMKYKSLNKWTAVGVALALSSTYSSFYIFAAYQNAKQHHIPIACTTTAALGAVVNTIAKTNFALELVAILMYISIWLHMNNLDKKLRKENQTNNVTIRRLFKSLFTILLVDFVGWSTNSLSITILDLIGITTSSVKSDQLLYYFITSSLNYLAYISSSSNAILLYSFSQEYQRAFDEFLPGWIIAIGPYDHGPLYKRHQWPISNLASHHAMIATTRCVLLVLLGATMAQAFLSTLDVAPSAVRNRRHGDGGGCGCGGGAVQLAVGCASPPPPPPPCGCGGSGGGGGGCGCGGGCGGAVKFAISCASPPPPPCGCGCGCGGGRGCGCCNGGGSIQLGISCASPPPPHPPCGCGCGCGCGRRKRMALMHLQRSLGGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW46</accession>
    <name>A0A914HW46_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HW46"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5024.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5024.t1"/>
        <property type="gene ID" value="Gr19_v10_g5024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5024.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22783" checksum="031574A5E086808A" modified="2023-02-22" version="1">MIIGECAPKQALPMRTLPFRPNEPVQLNSAGGSVADGARRRVRFQTELLRGLSVHGDLQGFCPINGLLSAYDNTLELRPTETRPHKRKEKEMGDKSEGNETTKPPPAKMAAIQRFSGRINAKKVVEELKKRKLDAEWTGDEEISIRDYSARIHILGSGSRTLITCSNPANRREIQAAIQASCLARFDVSASQQSLQTDSVSTGPITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWT9</accession>
    <name>A0A914HWT9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWT9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4880.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4880.t1"/>
        <property type="gene ID" value="Gr19_v10_g4880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4880.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10741" checksum="7AAD4851D2F76F7A" modified="2023-02-22" version="1">MGLACYYQSRSPESQAFRTALNAEVQKLIAMIHQNPLEPEIEKAEKAFSSFHADLAKDPWLPEKREIQEEFKKYRDELTRVRPTGSTDTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXH7</accession>
    <name>A0A914HXH7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXH7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g504.t1">
        <property type="protein sequence ID" value="Gr19_v10_g504.t1"/>
        <property type="gene ID" value="Gr19_v10_g504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g504.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8743" checksum="8C4789AABBE82ABE" modified="2023-02-22" version="1">MTRGKGIGMAGTFIHQNKKKEAKIQNIRFICRPVEEIPGSEKAGRVRKSNNQFLRLKAIWRFKFPEYENYAGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYB0</accession>
    <name>A0A914HYB0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HYB0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5774.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5774.t1"/>
        <property type="gene ID" value="Gr19_v10_g5774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5774.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30357" checksum="BE3AD47523C14BF0" modified="2023-02-22" version="1">MATVLQSEFDALQNKTKFNPICTATIIGPRHILTALHCLEDGQQNSEYRLSYGAAQSSKQQHNVLKNKRAEIIKSDLAIIKSKQAIIFSPRVRPICLFSNGASNSEFSTPKKFVSQHIKKERRPFIVAGWGFKKPKCLNESQTPNDQLLYGTMRMISKEKCRLQYAKTQDMPEDDPINAIEKRLYEYHLADKICVVPEPSVTEPGDSGSPLLSKIGQYNWVQVGVLHGGNDKRCAPNDVYSTKGLYSAYTPIDCDWIADVTDGEVKCRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYZ4</accession>
    <name>A0A914HYZ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYZ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g509.t2">
        <property type="protein sequence ID" value="Gr19_v10_g509.t2"/>
        <property type="gene ID" value="Gr19_v10_g509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g509.t2"/>
        </source>
    </evidence>
    <sequence length="272" mass="30735" checksum="2C1BC89129445C15" modified="2023-02-22" version="1">MRSDCAKAAVSCRICAHTREPRSNQPGVQMVVTNEPLELVCLDVLSIGRSRAHNRYVLVIVDHFSKWTVAEPIPDKSAETIARAFVENFVLIYGAPKRIHSDMGREFVNSTLEGITKIENKGDHTSGYDPQANGLVERMNQTIIKLLKRTTPSEWDWDLRLPYVVFAINVTPSETTGFSPYSLMFGRIANFPTDENIEFEADPRYTVDQETYLQAFNENLVEIMGEARQNAEIARERNRIEFNARSKVKCGKFKVGDRVMVVVPATKSECSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZJ4</accession>
    <name>A0A914HZJ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GCF C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZJ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5527.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5527.t2"/>
        <property type="gene ID" value="Gr19_v10_g5527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCF C-terminal" evidence="5">
        <location>
            <begin position="625"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5527.t2"/>
        </source>
    </evidence>
    <sequence length="964" mass="110322" checksum="4FFFDF89FF82A60C" modified="2023-02-22" version="1">MFRKPKSKLGGQDVRNIRRRADNGQVEGEESVDGSVRSASSSADEAADDQLQQKVVVDEGRQSDNDGLATTRPVGLSFDEREGDDVMHFKLKRHGAGGGHAVAAAAARRRSVEKAARKQRASAERARAAATTLKQVKREMPPSVETEQKQQQSDGATGGLHQNVHGNTLTTEHHKFKNEMDEAADVHAAFPTTMADIPDAKAVYEARKKREMMRQGGLSTPQDFIPLDDTVRLKYTGGPSGERARLVREDENDMSDEEEMGSFYSAKKLLQSEEEQRREEQAYFLAMEQGSSEEEVEVDDDGAGKTNRRRMGRGPSSGGERGGRGRMEPRREEYEEEEEEDALQRWEREQIRKGVSSNKVMQMQEELNATSLHYRGRPYHLTDSGEADMDIEIDMVEMEQYQQPHNARGDTALPPELSNGRSAKAVSVDDILGSIRQRLSDKKERQSANNELLAKTRGQMAENTELIHKFEQGMPQLELKFRMFQETRLYTRDLLDCLNEKIVQIDALDERVSEMWRQRTERLVARRRQDVQDQYERCAATAAGRTWAAPSADYTQREAEREARRNRRRRERAQHKSSETVHHEGLSSDDEETTSQEVFYRETIVSVLQGVDDLFLDTSDEFCQLEHIMQRILHWLSVDPISFEQAYVPLCLPKLLGPFVRLRLVDWRPLKNPTQQLHSMPWYRALLLAGLDNSGLEDLEHPALVFLIPSVVEKIVFPKIAKIVREQWDPLSLSESSNLAQLLRSLVEEYPVANANSKRMQEVLEGVYGRLRDTIDRDTFVPLYSKEAIESTETGCGAFLDRQFWKSIKLMRSILCFRSIVSDACLEELLVEGLLNRFTVLALQFSVLAHQSTLTKCRAVVEQIPSSWIPPSRPNSYRPLAALLKQVVELHRRDRKFLAHAQRFIDLLSVKEEEAEVLARFSKTILHLFYKRLAPKLEVYDVRAERLVHSAVHHLRRVRHEWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZY2</accession>
    <name>A0A914HZY2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZY2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6035.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6035.t1"/>
        <property type="gene ID" value="Gr19_v10_g6035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6035.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12448" checksum="F3682D15B04DB362" modified="2023-02-22" version="1">MQDRICVYELDSTRVLSSFCWPFTILFVQTRLHILANNHKAETNEKTIQMEQHHGQNVDQTRQTYQHHGLNVDQTGQTYQHHGKNVDQTGQTYQHHGLNLEARTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1N7</accession>
    <name>A0A914I1N7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1N7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g578.t1">
        <property type="protein sequence ID" value="Gr19_v10_g578.t1"/>
        <property type="gene ID" value="Gr19_v10_g578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="96"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="419"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g578.t1"/>
        </source>
    </evidence>
    <sequence length="746" mass="80567" checksum="ACC873F8DBE15A15" modified="2023-02-22" version="1">MSSGCSSPLRGPLPSAQCPPAECSFSDPPHPRCVVHRSFLITIALIITFLLLASPPPIEAAQLAASRDAHQQDAANSIQHELSAYDNEIISEPEIECGPGIVRFNVKTRQGNASAVYVRGQSQNEDCTFHNTRNITIELAKCNVRRKREVNPNPGIAYQMTVVVQLHPLFVTRVDRAYNVNCFYREQRQDVSVDFGVNELVTQQVMSHAIIPNCTYSVHRDSPNGPRVKYTHVGEQLYHVWSCPSNMYAMLLYNCNAVDGKGEEYPIVDSNGCSRDEFLMPQITYTEDRTRAMAASSAFNFPDRNTMLFTCKIKLCMLKDAECTNLTPPSCNGKRAKSAANGNFNVDNAGAMETETTATTAATSKAQIGGRAGRTEVSGEVDESAKFVESSTSSSSTTTTPKTTTTTTTPNVLEEETTTRTTTTPLTPTPTSAQSTTTVTPTTPSTTASSTTTTPATTDEQLLSSVERAASSESIEGTSAAQPKTSSSPSPSTASSSASSSTSVGLQTETSSTDGVTIQHKRDEKQREMPEDFPRPELLLQNDHSKTEAAEAAAKKRMERMGLKGEEAEEGSWTISASEEEEKGKQKKHIPQGGEDEFRGVTKPVQIFKKTKPEGTGDEGKPQMTGRTQRDTPAASRAGGSRRRMAEVDFDIQSPELMILDDYEPAAAAQKGSSQRSSVQEVPSFVDWEGGQRAASGRGVCFSPTALICAGALLLVMIIVVMVALLKLTRKGSAGGAVLEHSFYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3T9</accession>
    <name>A0A914I3T9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3T9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6624.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6624.t1"/>
        <property type="gene ID" value="Gr19_v10_g6624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6624.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17446" checksum="8BC648717BD8A1C4" modified="2023-02-22" version="1">MLLKIKKISNICPGPYNPNCNIFDHNCVGCDYVYNNTNACSVNVYCSCHYCCEPTYAAESCPNGCRECVKDGEGGCPENSANMPSWFDEIDHDGNNQIEPGEFDRSLIEVRNNQTSGCTAGKFVGSDGGLYPCVSLFTFVDEIEANFGPKFKYDIADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3U5</accession>
    <name>A0A914I3U5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3U5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g706.t1">
        <property type="protein sequence ID" value="Gr19_v10_g706.t1"/>
        <property type="gene ID" value="Gr19_v10_g706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="306"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g706.t1"/>
        </source>
    </evidence>
    <sequence length="702" mass="74398" checksum="F0A98953F2F3E04B" modified="2023-02-22" version="1">MATFSQSSQVFSPNVLDFILLFEHILSLCCKFGSILLMSLLLYIAHFRKGKLRVNSLSPCMQLYLVAQSVCSALGLPYVFYMLFWALPHILSGLHDNPYYSPYFLFWTGILEISYITAAPFLVTLLALERCIILKGTNLTVLWPRKVLFGAGLFIFVALWASTLFIYLGELPLQLDKVSDCKTASCETIRTLSIHSTGTKVFFGIINMICCIIFLLMLRSVGPNINLKNRTVKFTIFTEMFLNTLPALGSFLFNTLTGLVMANYVGELSISACPVDAFICALIYWKILVKSKAQSTVVTVKPMMTTATLGVIGLSGTTLLLCLFGIASIYDEIQSIWTELDLEMDRFKLETDDMWHDMLAMGAGTPSNRARRNAYGSYQAAGQQPAQTAGYNAPQPAPAPVAVCKCKAENACPPGPTGPAGGEGPPGLPGLPGKEGVPGITAENWHSAPFKGCINCPMGPTGTPGTAGKAGPRGRPGPKGSHGNPGRDGIPGIEGEQGTPGEEGRAGAAGKPGEKGTDAEKPIGRKGLRGPPGELGPVGPVGEVGGEGPPGKQGAAGVPGPPGLSGPGGNSGEEGREGSLGKTGQDAAYCECPNRGGGGKGKFGKKPRTAKGVRFARRRRFPPRLRRRAHAVAAFCFACRMLCVAGVACCARAACAANCSLSKRTESPAPGRTRWVTYSAVHWAPQPGNGTQMGGCIRLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3X8</accession>
    <name>A0A914I3X8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 9">Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with EIF5; this interaction contributes to the maintenance of EIF1 within the open 43S PIC. Interacts through its C-terminal domain (CTD) with the CTD of EIF5B; from the location of the start codon by the 43S complex until the formation of the 80S complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3X8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7276.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7276.t1"/>
        <property type="gene ID" value="Gr19_v10_g7276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7276.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20177" checksum="94B9F8F5D393C52F" modified="2023-02-22" version="1">MLQQPLVLVQDVQALPKPGKGGKNRRRGKNENDVMKRELIEKDGDDQAYAQVTKMLGNGRLTAFCFDGKVRLCHIRGKLRKKVWINSGDIILIGLRGYQDDKADVILKYTPDEARILKNSGQLPESTKLNEGEEQNEGEVEFADSGDRYDEDEVAAQDRNFSLSESSSENSDEEEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I489</accession>
    <name>A0A914I489_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Metalloendopeptidase</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914I489"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6668.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6668.t2"/>
        <property type="gene ID" value="Gr19_v10_g6668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1940:FF:000002">
        <property type="entry name" value="PHAryngeal gland Toxin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF829">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="176"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="392"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="561"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6668.t2"/>
        </source>
    </evidence>
    <sequence length="601" mass="66615" checksum="B976F6C689C141C2" modified="2023-02-22" version="1">MFLLCQIAVGHQQHFLSVRNSMFSSSNAGGGGGTSAMAGGGAVAQLLTNSPEAHNLYGHFSMPEAGGGGGGGMQQKGLRSDSRPGDDQKSRAALLPASTPITQEESGARHFLVDATKSAVGHHSAEAYAEMKPPIPPSTPIVKEPAWLRSGKFQGDIDGVDEHLLRQLQDPTIQFNALRNRQLIWPRGVIPYELDLAFSLSEARLLQRVFRTYRRRTFGCIRFRPRRSGEADYLNIVKGIGCYSQVGKTGGKQELSLGRGCLFNETITHELMHSLGFWHEHSRADRDEHIMIRWANILPGMLYCFNIVLMDCLTGMDSQFDIVSSAIQDTLGEPYDYRSIMHYGSSAFSRNGRNTLEAVVDEFTNIIGTVMELSEMDVAKIMKLYRCRRHESAKGDGDSLPSSTGSRSNIVPWRKRKTLSDRHLSDNHNQSPPSSSSSSTRRPPMPFVDVDDEDGGADTAVPTGNEDTEFGVPRIFSTTTRRSTTTAVEEEDESDEEQSTQSSLAASSASRRRRGGGHCRDHFLDCPQFRDYCKRISFYFIMRSYCPHTCGRCSSDGAAPAARARARAAVEERTVEADDDENNENGEEEEEGERHSKRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4M0</accession>
    <name>A0A914I4M0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4M0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7477.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7477.t1"/>
        <property type="gene ID" value="Gr19_v10_g7477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF13">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7477.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11510" checksum="48E294EBE76F98AE" modified="2023-02-22" version="1">MNGIRCSETMNRTSPARLYSYGLGWSLNIMGFNGWQHDGRMPGSASMLVRLDNGLEMAVVVNKEYSDRDFFHELGYILHHIGNNCDWWKDAGIDLFPAAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4V1</accession>
    <name>A0A914I4V1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4V1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6902.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6902.t1"/>
        <property type="gene ID" value="Gr19_v10_g6902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6902.t1"/>
        </source>
    </evidence>
    <sequence length="437" mass="49292" checksum="C5F5195C5964089C" modified="2023-02-22" version="1">MAFHKIDTDSVNSITNALDLFRIPPTNVSVSSSKVFELLPSNPLTDTPYHFKLHSSQNFIDLSKCYLLTEFRIRKENATGQLINLEADDQAVCPIQMIGQTFIRNIRMSINGREIFNTNSLMAYKIYFSHELSYSTTTKDSHLQAAGYYRDPGLTLEDGPGCVARRNLFAGSRTAQFIAKIDADLFNQPLYLINFCELDVEIIPNDNDFVLIGLNAPVRYRFELTGLKMYVKKVSLMDGLALDIARKLELKPARYAVRKTMMKSMFISQGRFEFTSNIFMDQIPRRIILGLVANDDYVGTSARSPFNFQPFNVREISIIANGRSYPQAPYDLDYPNKKYVRAFNDMNEAVGFTNTTESNGITFEQYGKTHCIYVFNMTSSGDDQAGLFDLIKNGTTAVCIKFSQAVPFGGIMMVVMGECDALVMLDKNRSISTDTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5S3</accession>
    <name>A0A914I5S3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF659 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5S3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7153.t3">
        <property type="protein sequence ID" value="Gr19_v10_g7153.t3"/>
        <property type="gene ID" value="Gr19_v10_g7153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033375">
        <property type="entry name" value="Cggbp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344:SF1">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF659" evidence="2">
        <location>
            <begin position="99"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7153.t3"/>
        </source>
    </evidence>
    <sequence length="481" mass="53820" checksum="102F63A512103B15" modified="2023-02-22" version="1">MSLIINMFYSNTVTCSKFFQLKQHDETAKHKQNRDRYQQEGSSISQQPFLTQESFDTEQPDPFVEDLCDALIGANIPFFKINNPSLKYFLSKYTNRTIPDESTLRKNYLKICYKTSIERIKRQIGNSFIWVSVDETTDPLGRYAANLLVGKLDVSGFHPPNLIAVKMLEKTNFETVSRFVNTGLRDFGVKEENVLLLVTDAARYMIKAGKALSVFYGNMTHVTCVCHALHRVCEEVFTKAPYRVKVFKEICPTLALPPQPVLTRWGTWMTAVEYYHKNFYSVKAVVDSFDPENAISIQKSQRAFNHPLIRQHLAYLQSNFSILAPSITKLEAQGLTLAQVLNILAEVKTSIAKAEGDNGRAIKAKLELVLANNPGFAKIIAIAEVLKGGEAMVEMAPDMMASMRYAPLVSFLRPGPNRCTTTRAATTSSSAAASSRRARHDEIAPLEHGRIRGQSKQVNGGEATDGPVQYQATDTARTVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6C9</accession>
    <name>A0A914I6C9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6C9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7314.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7314.t1"/>
        <property type="gene ID" value="Gr19_v10_g7314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7314.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13227" checksum="E47A2D9870F89025" modified="2023-02-22" version="1">MVASFRKKLMGWRETAVVFAALTSGNWPPLSHFARGNDRASRRLPLGRSFSEPCGVNCPSHTLPEAMITVCLSSLPPHSLSLCLCLYILLGGGLSPLLSIPSAAMFLPRSALSVIKRSLGGCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8P2</accession>
    <name>A0A914I8P2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8P2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7930.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7930.t1"/>
        <property type="gene ID" value="Gr19_v10_g7930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7930.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30837" checksum="563A8F2DAF15A4F1" modified="2023-02-22" version="1">MERKRRRVVTSEEKKRSKEKEKVKRKREKKARALEKSAVAYASLTRTPLAAHLLRTLSITFVANFDYLDFSEEVRLLRARIAQLERQQTMNTRTSLRAKGNEAAKCVESERVEQLELALTKTNRKLEELGNNLKDEREKGMQLKGELTRMGKNQNKQQLNIVALQKTVAALNAKINGKVGVLDKRYKCTHCSFSSHRAQHLKMHKLIHTGEKPHKCQDCGQRFRQSNHLVNHQRVHTGEKPFKCNYCDKPFTQRSSLNRHLGRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8S0</accession>
    <name>A0A914I8S0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8S0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8332.t3">
        <property type="protein sequence ID" value="Gr19_v10_g8332.t3"/>
        <property type="gene ID" value="Gr19_v10_g8332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048846">
        <property type="term" value="P:axon extension involved in axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033563">
        <property type="term" value="P:dorsal/ventral axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8332.t3"/>
        </source>
    </evidence>
    <sequence length="212" mass="23968" checksum="3D4698AD829578A2" modified="2023-02-22" version="1">MFIWKFRAIFDNEVNQPFFSSFPTIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGRPINLGLWDTAGQEDYDRLRPLSYPQTDCFLLCFSLVNPASFENIRAKWYPEVSHHCPRTPIILVGTKLDLREDPKTLDKLRERRLAPISVAQGHQMAKEIKATKYLECSALTQVGLKQVFDEAIRAVLCPQQVKQKKSCAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8Z9</accession>
    <name>A0A914I8Z9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8Z9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g774.t2">
        <property type="protein sequence ID" value="Gr19_v10_g774.t2"/>
        <property type="gene ID" value="Gr19_v10_g774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022559">
        <property type="entry name" value="SUP-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34149:SF2">
        <property type="entry name" value="PROTEIN CBG11905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34149">
        <property type="entry name" value="PROTEIN CBG11905-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10853">
        <property type="entry name" value="DUF2650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037782539" evidence="3">
        <location>
            <begin position="25"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g774.t2"/>
        </source>
    </evidence>
    <sequence length="516" mass="57732" checksum="CE503F7CEE6C5310" modified="2023-02-22" version="1">MPMPLLCLFIILPILLLTSSSCLAVNWAFLSDQSQCQVGCLNGGVCAFQREDPAQQKCICLIGIWEGDRCERNVAGPDDATMESKGGDGKMKDEFEEEEWPPDEEESLEESAEEGELKIKSDDKKEKREQNGRWMKEAEGEGEEEELMDEMRKVPENPAKYADDWSEEMGKMPEEEADEEKNGPLPTRVLGKKPDNEREGRMRVSEGKKSSDEKKMLDGDGKSRLGKSTSPNVPRQYLETNTIELGEHFEAPRRGESSAVTIARGPKDGNEEEVFEEPLRKEAGSKKVSKTTTIGRRRKLKMDEWSGRGEGRGGRGEEKSGGRREEGEGRGEERRGQREEGGGSWMCRMGMDSDDSGDRSGCLFLLIWERGGRGDNERSGLKEIIVTMQFYSPFSSFLNCRRSPKFPFRKCLFLLQLTLMLMAVDGGEVREGLEKVGDRVSGAVNELAEVKSVIPQSGQLWCPIPAAGTKCPSSSPFHYYRCCGPLNNECCLSLQTAALCILQVFIQSHFGVFFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Q4</accession>
    <name>A0A914I9Q4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDK5 regulatory subunit-associated protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9Q4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8594.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8594.t1"/>
        <property type="gene ID" value="Gr19_v10_g8594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8594.t1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57393" checksum="2CF1D3D30042A433" modified="2023-02-22" version="1">MEHLPIDIHSNKLLDWLLSRRHCPKNWREAVEAVRSKISHAIQDMPENEQILTILSNAQYINYFHCKQIVEILRETEKETKNIFGMYSSQRMKDWKEIISLYEKDNVYLAEAANFLQRFVQYEVPALRKQIAKAENTSGESERKERDYAKQAAESRRNLDKDLAKWSLSAKVGDLRGELISAANATQPTELGVVVGTELGRMVAYFDQFSTFVGKQLDGMFPIARFLLASLPQRPFSAVTVFEWRHGRRPNAVVPQICLQPLPSAPTDNEQTEEEAKEDEIDFGEEEDEIDFCSNGNADAIELISDDADGVLSENVPPVADDGIARGEEALPILDHLGLRTEFLDELDQLASFMDFRLQDELTECGASIYLDGMAQKPCNGAAETGVEELRTWLTELKRTSAELSEPNKMQRLRMRTSPRFVDEIVAQLEQKRRLEAKYLHQEQLSAQRLTQCAAEIRSAQKLLDGVVEAAKRLQEELEKDLSKRYNGREVYIMGEINAVLYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA79</accession>
    <name>A0A914IA79_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8039.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8039.t2"/>
        <property type="gene ID" value="Gr19_v10_g8039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8039.t2"/>
        </source>
    </evidence>
    <sequence length="233" mass="25868" checksum="3B6C1F2AA710CC41" modified="2023-02-22" version="1">MRGPIIATANFDNKWTSPTLACWSLLPFSSRLPFPASVGGDDSTSSPEELTECQQMSAKCRDNWDECFPREAYNGDACCQQGASFKCVEDAKRMNCILAGHPDLESLIKCIPKFSACKSPSLCSNEFHEDKAIIEKYPKVLKCLQRKHSDVDDNCMPKEPFSSKEECNAPYLCDCLNPPISKCLSILLEEFGVDIKRRLLQSYNNMLNTDSNSGGICCTAAAVPRRPTLSMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAA1</accession>
    <name>A0A914IAA1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAA1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8129.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8129.t1"/>
        <property type="gene ID" value="Gr19_v10_g8129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8129.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10563" checksum="6191931227E02889" modified="2023-02-22" version="1">MPNMLASIQKIRVLRSTMFLHLPPTRTGNWIVQRQDVALQNSNVRQYSNTGILQIRLRVLVCPPRQRVAFSAFEFLKHSTFLKVVQWTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAT4</accession>
    <name>A0A914IAT4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IAT4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8467.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8467.t1"/>
        <property type="gene ID" value="Gr19_v10_g8467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000002">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8467.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16964" checksum="AD633DCAD5BE1B56" modified="2023-02-22" version="1">MALRRIKQEIKDLERDPVKDCSAKPEAENNLYIWKATIKGPPDSPYEGGTYNLTIRFPRDYPFNPPHVTFNTKIYHPNINSSGGICLDILKSQWAASLTVSKVLLSICILLCEPNPDSALELDIAREYKSNREQFTKTAREWTEKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICA0</accession>
    <name>A0A914ICA0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICA0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9500.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9500.t1"/>
        <property type="gene ID" value="Gr19_v10_g9500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9500.t1"/>
        </source>
    </evidence>
    <sequence length="582" mass="64052" checksum="3FB7B851CFD10B5A" modified="2023-02-22" version="1">MWTHFGPYLILEIGESSAVLVPIDKQQAEPIKVPIERLIRVPPGIPDISTIPRGKNPFKNVLNTLVTGTPNREKRDKREPNSAQMMQLGTIAQVKGGDERERDGKVSDLVGKLGKWAIQSFPETMDVDKPEDGIFGWNVTCTEGQGEHEFCGALSTLELDPALGNAGLGTMAVKTPLQALFSVFLLKAGTVKSMTAARNLAQAIVEGEPKEELRLFVAKRGDYVGTGLYPTEEDQMKALESWFEKCSVARRALEESEFGRIGMQGPEGIDALAESEKKKWKELLEATPWVLERMRAKIVHKATRFVAHPRVIIGDFSANQLGEVLDQTAIVGPKEGTLAEVVRSLKPTVLSSKVKAALIIAGRDSLLAGEPIEVMAEQFEMIAKWCRRFPHVQFLWTCPPYVHNKQAEYEELVARLRPMMSQPPFLPVWVTENGRSIGEVFRFGNSFDNLRVTADGMMKDAGVRALKAWLFTQTEFPGDQQLKIRAVHSVVRVIPSGGPGDHRRAGSAVGTASGGLGDPRRHSFGSAGWEDFRRRSQGSGGLGGPRRHTFDGSTGAGRFHPYGRGPLRGGNDQRGQGPQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICY9</accession>
    <name>A0A914ICY9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L18a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICY9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8766.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8766.t1"/>
        <property type="gene ID" value="Gr19_v10_g8766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="6">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8766.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23488" checksum="DE808C95C59EF8E3" modified="2023-02-22" version="1">MRTYSSYKLLELGFCKNRNKETNFVEFLQEKILKTAISNAHQSIRRNIKEMVIFASNHVVAKSRFWYFTSMLRRVKKTHGEIVSCQEVFEKKPGSVKNFGIWLRYDSRTGHHNMYREYRDVTEAGAVTQCYRDMGARHRAQADRIQIIKVQTIKVADCKRAGVKQFQDSKIKFPLPHRVNAKRRKMAPFTTQRPRTHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICZ2</accession>
    <name>A0A914ICZ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cleavage and polyadenylation specificity factor subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g97.t2">
        <property type="protein sequence ID" value="Gr19_v10_g97.t2"/>
        <property type="gene ID" value="Gr19_v10_g97"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="13"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="479"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g97.t2"/>
        </source>
    </evidence>
    <sequence length="1472" mass="164490" checksum="73E2AAB417178D05" modified="2023-02-22" version="1">MYSLLHETDDATSVNFSAWGNFLAGSGNQLVTVGSKCVKIYRLNPFFVPFGGADPSTRLECLLSFTLMAPVRSLAVVRLKVNPVCHALAMTFDDAKLSIVSVNPATMTLNTISLHSIEDEFLRDGYTDENIHQPELRADPDNRCCAFTVYGRHLAVVPFSIADFVQQQQTAKEDVGGKQHQLQQQMLLQSYTVKLRSLDEGLDNILDMCFLHGYYEPTLLFLYEPIQTTAGRASVRFDTVAILAVSMNIKDHVHAVVWHFAGLPMTVARCVPIRVPIGGVCLIGANEIVYLNQSVPPRGISLNSCADEFSRFPLNDLQHMRLSLDGSAIQALDSPPNDLVIVLRNGDLFTDHQSIRHVNTLHTDRFAVEQPITKYNNTDDSVHCAMLFDDDDNYLYGNDFCNSFHLDETLPTLCARRYNFEVVDSLTNIGPCKWLRTCSASFVSDVFLKRPRDIFFDMMTVSGHGKNSSLCFFHCSIRPQIIASTVLDDALQIWTVGRHRHVHEMADGEAHKFLVISRERSSVVLELANDNMVELDTPCFCQTETTVAVGELAHGAIVVQVTPTTVLLVSTIAAQQLEVLTVDSNFPVISASISDPFVVLLTLNGRFILYRLNNTSSHAAHLQQIPVLEVLRHAKSPITAICMYRDESGLMELCVDNEEEEAMDQQQPDNVLQPLALNTRLFASRSTDQDSIDGMKQQQEASAVESSIYGLNVDAFLYGDDDVDEKSASVHHPPLLPCTGNILPSTSGSTSNLNNGPAHDSSTCFGVQPPDRVKPTYWLFFARENGNLYVYSVPELRLCFIVKKLSHAHEVLYGDAQTLLEDDHRPAQHAFLMNTPVILPQVQSTETARVIAGGAGAESMMLKPEEVIFELFVHGMGINKGRPVLSVLVDDQMVFYEMFRHDDHIAGQLSIRFRRLPSTVVVREQRFLGPNGRAPVEAARDAEQRQRSYICPFERVGQLSNGLFIGGGYPSLLVCEQSGPCLRPMTVDGPLASFASFHNSSTCRHGFLYLTRNEHLLRIATLADKMDYGSCGGDLCCALRKSPIEQTVRHCVYLLQPGIFALILTEQQPNQKQCSVVNEEKQMETFERDDNFILPSLDSYTLKLFSTEDWAFVPNEVFQFDEFEVVTCCEEALLNSESTVSGVQNYLAIGTAINYGEEVYVRGRVLLFELVEVVPEEGRPTTRHRLKTVYDKEQKGAVTSLCAVNGFLLTGMGQKVFIWQFRDNQLNGVSFLDLHFYVHHMTSFRELALVCDLYRSLSLIRYQEEFKALSLVSRDLRPTAPAPMTAQFLVDHRQLGFVLTDELANVTLFNYLPETKESIGGERLIIKAALNIGSLINSIVRVKGHGAECLVDAKFQQGIQTCFFATLDGSLGYIRPLTEKAFRRLHMLQQVMNLHVPQPAGLNSRGSRAARPQRTGTHQQISLAKNIVDGLLVMQYLHLSVQDKTDLARKLGTSRYQIIDDLTELCRTVTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID18</accession>
    <name>A0A914ID18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID18"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8784.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8784.t2"/>
        <property type="gene ID" value="Gr19_v10_g8784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037769692" evidence="2">
        <location>
            <begin position="24"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8784.t2"/>
        </source>
    </evidence>
    <sequence length="336" mass="36578" checksum="E2536247A020DAA4" modified="2023-02-22" version="1">MTMLRAADDELLGLLVLMLAVGGDGPCIYSPTHPIVSSGRRVEETDQKSLFRHLSSWPFTLPRALLMGAELSILLGGQTEHRPKEEKQQKQKRKFKKDGVGVGRGHVVAKEVKAKEEEEGRQGGDRAKGAGGARDGRNRRANIMHHSPFRGLRRAASSSASSINCCSSVPCATSTTGHTYPYPRTHSTLMVIPSAVRPPIVSTGAGTIGSRNWASSVNTSGTTRPQSLLDSMDEQNNNNEQLLLHFPYHPNGGQPLLSNNNNNNNNEGEPWPTDGGVHVQQQQQQRQSLVSQYGFQTHRPRPPLNRAIPPIPESRSNESIQSGLVARQQSVGSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEM4</accession>
    <name>A0A914IEM4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9514.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9514.t1"/>
        <property type="gene ID" value="Gr19_v10_g9514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9514.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34613" checksum="78ACB6E47A1AF3EC" modified="2023-02-22" version="1">MEYFSPTMKMDVFKFENFQIGDELASHLSSWDPFESHPFSLNILNENIEEEPKLSKRFSICERKHSECAKSTDELWKMANSFKGQNMLDFFDMSRSEDTAQKPAFKSLAERRLKFQHDLRWSFDVEDNKKLSREDRVVGRKPQTATSTPTKHSSPEHQHRTFIAQNSPATVQSAKIACVAVSKNEMQTKNVPSSAIRCRAKSIRKRQFVNGIHLKFIKPASQCPDWDKPGHRDQKPGCTMWHPKAPCYFYPNCRLTAELCGFAHPFCGNYGCKCGNGAQSPQLNHLPAQLTTNVTKRKAFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEW1</accession>
    <name>A0A914IEW1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEW1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9587.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9587.t1"/>
        <property type="gene ID" value="Gr19_v10_g9587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF185">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9587.t1"/>
        </source>
    </evidence>
    <sequence length="516" mass="57705" checksum="28BF21BC3A666ABA" modified="2023-02-22" version="1">MCLSSTNGFEVLRMPKHLARFLNIENQRLMPRSYFNSPPIPTPPTLASNSSNPSNNNSMVGSVLQQQQQQQQQQKNPKLYKTELCRSWMEHGRCNYGERCQYAHGEKEKRPVPRHPKYKTEACQSYHKTGYCPYGPRCHFIHNENPSQLNALIEQNEKALRMVQELATLPINGSAAEIPRRSLMVVSSSSASLGNSPFGSMLQKNNSVHAFNSFHSHFLGKAQSNNALQHQQENCANFFPFNVQHKGHHHQLPVGLNLLGSNYPQYQQQETTFYSNHQCSPEKQHRHQQNQRLSSSSYESSYETYSGISSKHQRPAEIFRHGMTSPQLNHHYQISMGHPTSDSLSPFGKEQQHGHNNGDEWCMATKAQEICTSKGFAANNDLDPQQLLANLCSSDDEYSRSSLISSTADSGTESPPMAFDDDTLTKSNVGTKKLIGLQMIGHTLLPDTEDEAQHRRSSDGDTVKVNAVVNNYSTASSSLASLLSSSSSSHAQHKSPVAPNASKIRLPVFERLSLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFG0</accession>
    <name>A0A914IFG0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFG0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9392.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9392.t2"/>
        <property type="gene ID" value="Gr19_v10_g9392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002104">
        <property type="entry name" value="Si:ch211-266d19.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9392.t2"/>
        </source>
    </evidence>
    <sequence length="118" mass="13206" checksum="216CA9BFD330F5AC" modified="2023-02-22" version="1">MLTHTGVKPFQCTECAHRFSQSGDLKRHMLIHTGVKPFKCAICGHRSAQAGNLKQHMLIHTGVKPFKCAICGHRSAQAGNLKRHMLTHTGGGRKFKCTDCHKAFKNSSNLKVHLRRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGV8</accession>
    <name>A0A914IGV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9772.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9772.t1"/>
        <property type="gene ID" value="Gr19_v10_g9772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="412"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9772.t1"/>
        </source>
    </evidence>
    <sequence length="617" mass="70055" checksum="2EC6F06BD54D25C4" modified="2023-02-22" version="1">MSISPKSTTAGDITADQRNLGSTFSNLEPSEQVRILLARIAELERQQSTNSPTSSASFDLLEAAADDRGKIAAEHGGGNESAAAKDGQQTNTAQLEMKKELKNMKESFDKKLEEQMGALQTKMEKYQNKQQQTIDSLTQKLKVSIDQLSLKHQEHEKLLNAHKNLMEEKIDWLNDDQQKLVSIDQFLLMQSDQKALLQRLNALEQKLMNSEQQKTDQKALIVMEERVAKLELKNKELRAEHEKLSTDHKNLKEEMKEQREMDALKQQKETNHKIDSLIKDQQQQIANMIRKMEQKQKDAQKEFQRKLDESLNGQAMVVAKLEEQKQSNANKFAELEKQKVSNANKFAELEKQKQSNANKFAEIEQKNDKLEQYQNEQQLNIIDLQKTVATLTETGLIPENRWDFDDCHSSLALSELDRFAQYNGENLGLIPENRWDFDDCHSSLTLIGAEQLIVQYNGEDWGWSSVIAEKTMPENPYGISYFEVTILEKTTGSILIGLATKQMPLDEFVGDYEETYGYGSHGIFLGHEVDGCRHRLLSGRPYIGGNPKFGVGDVVGCGVNLATYQIIYTLNGELLYTDNLFVESADDLFPCVSLGRPGTKIEANFGPNFQFNISDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGY9</accession>
    <name>A0A914IGY9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGY9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9795.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9795.t1"/>
        <property type="gene ID" value="Gr19_v10_g9795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9795.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43204" checksum="0D2FC6B34482E523" modified="2023-02-22" version="1">MGNLLVSRQWLSAYEDENLETESGSLVDRMKHLLSTGDDADVKFLVGQGDEKETLSAHKLILKAASDVFGKMFLFDAQHAKAAAAGTEIKPVEVPDVEVGAFKAMLSFIYADDPSGISEDNVFAVLYAADKYNVSGLVKACVNFPKRKLRNVFLSIEQARLLGDTLPLCKDFARDCLDYIDKNAASLIQSEDFLQIDQQLLCEILDRDQLLINDELTIWNAALRWADEKCHQNGKECSAENRRAMLGPALFKICIPRISQKDFSEIIVRSGVLTSDELVSIFQYYAQPDADQPEQYPLQFPTKRRTTSDPYKADGQIVVKIKRVSQFARVNVNSSRLSEPVYIRGACLGRYWRLRLPTPTNLDFTYAATMKQPLVPIGAVPVRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGZ4</accession>
    <name>A0A914IGZ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGZ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9799.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9799.t2"/>
        <property type="gene ID" value="Gr19_v10_g9799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="263"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="499"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9799.t2"/>
        </source>
    </evidence>
    <sequence length="791" mass="89071" checksum="953A9C1B7EE67902" modified="2023-02-22" version="1">MTKNPNSSLGRMEHLLSTGDGADVQFLVGQGDEKELLPAHKLILKTASDVFETMFRFDEGNAKTAAAGTEIKPVEVPDVEVGAFKTMLSFIYADALGGLNGDNAISVLYAAKKYDVPGLVKACVAFPIPALRNVFVAFDQARLHGEELLGRDQLFVCGEIAIWIAAFIWADEQCRQYGKECSAENRRAMLGAALFKIRFPLISTEDFVENIVPCGVLTDAELLSVYMRHCHPGRALPEQYHLQFSTKRRTVTKSPGDDPYKAIAKIRLRIKGFWYLEFAEDEENSRQLSKPVYIRGLRWKISASSRTNCDHKCLSFYLQCNAEDCDPNWSCAWSATFKIVSQMEEKKDLIRDYCNTFNATNNRAGYALFTSLKKLRDPKNGWYDALNDSVILEVNAFIWADEQCRQYGKECSAENRRAMLGAALFKIRFPLISTEDFVENIVPCGVLTDAELLSVYMRHCHPGRALPEQYHLQFSTKRRTVTKSPGDDPYKAIAKIRLRIKGLWYLEFAEDEENSRQLSKPVYIRGLRWKISASSRTNCDHKCLSFYLQCNAEDCDPNWSCAWSATFIIVSQTEGKKDLIRDYCNTFNATNNRAGYALFTSLKKLRDPKNGWYDALNDSVILEVNVIADKPHGVERACSLDDGDVSAERAEDDGFEKHQQPTTDPRYPKRQIHSLCMVLTRKCFDEELDPICAKEGGTPGECQFCLTGLCNKVVPLTVVRGSQSPPPPFVSPPIVLKASNEKGGDVMSRRARSLDDGDVSVERAEDDGLRCTNNRPKTPQNPTKPNIYIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IH11</accession>
    <name>A0A914IH11_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A914IH11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9831.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9831.t1"/>
        <property type="gene ID" value="Gr19_v10_g9831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9831.t1"/>
        </source>
    </evidence>
    <sequence length="601" mass="67127" checksum="F263E2F8896C3341" modified="2023-02-22" version="1">MMRVPTEAAAAAAFAFRVFLHFPIDIISSSSTSRTCWCCRRRYRPPLAFLRRTYSAFGAHRKSFEMCSNEEQTLYEKAITRLNFLQSNAQTLALARNQQESRPEWKLQETREFLEMIGISLDDIDRLNVVHITGTKGKGSTAAFLESILRSFGYKTGFYSSPHLVHVRERIRIDGRPISKRTFTQQFSRVYDAIFEHQKEVQCMPAYFKFLTLLAFRIFCDERVDVAIVEVGIGGQYDCTNVVRRPVVCAINTLDLDHTKVLGDTLPEIAWNKAGIAKPGAVMLSVQQPPDAMRVIEKRCVERQCPLFIVPPLADYRWPPSAKQPELGIAGPHQHTNASMALQLARIWLLKCHRRHIETADANGTGMPESNNNNSSRNNCGTIAASVDEQLQLDATTAVEGRNRLSAFTLTPGVAHALAQCRWEGRSQLLRHGQNIVFHLDGAHTPQSMQFCAQWFVQSSSDVAAASSSDSVQRLLLFHCTGDRSSAQLLPNLSGCRFGMALFCPAVIDPPDRPSSLGRDSTNVKLDLNAELRRCEQDREIWRQIHPDQPSEVLTCVSDALAKVHALADNNTGTELHVLVTGSLHLVGDFLAVLDPSKANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQW6</accession>
    <name>A0A914GQW6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQW6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10565.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10565.t1"/>
        <property type="gene ID" value="Gr19_v10_g10565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10565.t1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49762" checksum="7DE4B6FCBFA8686E" modified="2023-02-22" version="1">MLCQIDRRFYIVEFLVPPGQQDVDNVWGRNQYLLDEGLLVEAATSLGVLWMVISERAYQVLPITDDHPHPRRVLVLEMARKILLVLEGDGDETFSVCGYDEEQRMRVPLNVALPLIWQPNVEHGDYNDAYSPNNNDIILESDNNDVTGQRPVHQYPPPSSSSLSVRTSPSPSDRSSLSVSLPPTPQPTTSEFHTPTPVLPPSALIALSGAAATPPAQPHPAPVFIQQIYNIHLPPVLPRPPISQFLTTPLSAFRPFRALTGSTAATAVARPSTRLFCGDVDHLRKRGVPKHVRQLWQKLDPSARNRADEELHGPNRPMSVASTSSDASSSSRGTTTTQKDLRKLSIIRKLSFRCPTAEFVPREEDEASDDVDATGIGRMDRNFLRQFIYRQFSAAISMIYQNDVECYKLEEQNTEKYYLRYLLLNVSDGPATQLQKGRTLHNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRG6</accession>
    <name>A0A914GRG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1062.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1062.t1"/>
        <property type="gene ID" value="Gr19_v10_g1062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1062.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="13981" checksum="6C3273D29F3DB1A7" modified="2023-02-22" version="1">MGNRGPVVAAFTPAQMMQGAHFGSSFYHPSGQPSSANDTPPQSHRVPTIAASLSFALGAASSSNAVHTTRTSTVAEVEEGIHRGNIKSPGGGGDEEDDMDEFDEEAMDDYGRGGGARPTADLRRNFDDNIGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTM9</accession>
    <name>A0A914GTM9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="30">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g11154.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11154.t1"/>
        <property type="gene ID" value="Gr19_v10_g11154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="term" value="F:calcium:sodium antiporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:U5 snRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
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    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="20" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="21" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1065"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1187"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1217"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1693"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1767"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1799"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1838"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EFG/EF2" evidence="28">
        <location>
            <begin position="668"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor EFG" evidence="27">
        <location>
            <begin position="782"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="26">
        <location>
            <begin position="1373"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="26">
        <location>
            <begin position="1500"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11154.t1"/>
        </source>
    </evidence>
    <sequence length="1866" mass="209487" checksum="3858A8B11D920508" modified="2023-02-22" version="1">MLKNRSCRTNQTKCLKIEMDSDLYDEFGNYIGPELDSDDDEEIQPCNEEENEQKDENMEQEDAEEDGESPVIPANQIVLHEDKKYYASALEVYGEDVETLVQEEDAQPLTEPIVKPVKLRRFQAHEHLLPETVYKKDYLPETFITERPRSSTAWLSRPIQTFIVMRIATPAHNAGHAKLPEQVLSSEYFRHTRTCQFFRRMHRGIPLGGRLLRHAIQEHLPITICLNKIDRLILELKLPPADAYAKLKFILDQINNFVQTFGEDSIPLFSPLMGNVIFASGRYSVCFSLESFANIYAAKHSQLNAKEFARRLWGDMFYDSVTRKFTKKAQLGAATPMLRSFVHFILEPLYKLFSQVVGDVDTCLPKLQQHLGIKLNKEEQKMNVRPLITLICQRFFGSFTSFVDLVVNNIKSPIKNGQRKVQHCYSGDVTSQLPTEVASCNPNGPLYIHTTKNYATQDATAFHVLGRVFSGTIHFGDEVKILGENYSIQDEEDCRVMTVGRLWLPVARYNIEVNSVGAGCLVLMEGIDQPVTKTCTIVEKDYDQDELYIFRPLKFNTCSVVKLSIEPINPSELPKMLDSLRKVNKSYPLLTTRVEESGEHVMLGTGELYMDCVMHDMRKVFSEIDIKVADPVVSFCETVVETSSLKCFAQTPNQKNKITMIAEPLEKGLAEDIEGEIVKISWNRKQLGDFFQTKYEWDLLAAHDTLPSEVDKELLKTVRESVIQGFQWATREGPLCEEPIRNVKFKMLDAQIAKEPLYRGGGQIIPTSRRCAYSAFLMATPRLMEPYYFVEVIAPADCVTAIYTVLSKRRGHVTTDAPIPGSPLYTIKAFIPVIDSFGFETDLRTHTQGQAFCMCVFSHWQIVPGDPLDKSIVIRPLELQPAPHLAREFMIKTRRRKGLSEDVSVNKFFDDPMLVELAKQQDLFSGFGRSSPSPAVITSTHLRPFRCYFGTSKLSRLCPPHTLRTSTYFCCLSSSFHEHDQPPYSPSAPSSSMAIANEAEVATVYSIPRRAVIYDNRNNRTTTTEAALIAAEGEHAKHCLPAKPCRPGLILSVWEPQEVPSLTRMFRALVYLLAMAYLFFGVSIISDRFMAAIEVITSQEREVELTKVTGERVKVLVRVWNETVSNLTLMALGSSAPEILLSVIEVFANNFEAGDLGPSTIVGSAAFNLFIIVIPSNEIRRIDRVDVFWVTVIWSSFAYIWLFLILCVFSPNVVDVWEAVLTLTFFPLTVASAFVANKHAKSFGQRLLANKAITSFRHTPRLGKQKRRDSAKGMTNGATNDVEVALLDQLKSDSNSNSLVQQKRYLDIIKRLRNENPNLSVAELERLASSWIFTEVPKTRAFYRIQAIRRMTGHGDITSKKLREQAQEDLPPVLPLQPEKPKQVTVGFDPVEYCVLENAGTVELRVTVDRGSLVVPTEVSVNYATVPDSALEHEDFVPTQGVLTFGPNETTKFVEIGIVDNDEYEDDEQFFVKLTNLGAFCANNPSQKMPAHFAEEADCATVMIIDDDHGGAFSFTSEVFRVPETQGLFVLEVRRHRGARGTVYIPFTVINGTAKAGKDFMVYGKDLLFLNEQTKAEIHIEIVNDDEYEKSEEFFVELGTPEWRVGKGQVEVKEGSPDGRPILGEHLRCKVVITEDKEFKNFIDKMVTNANVGFLDIDGDGSLSLKEKALHYVSLFWKLLFALIPPTDYLNGWVTFSVAIFAIGVLTAIIGDVASMFGCTIGLKDSVTAITLVAMGTSLPDTFASKTAAINDKTADSSIGNVTGSNAVNVFLGIGLAWAIAAVYHWTRGTPFLVEAGSLASSVTMFLIGSVVCFGLLQWRRYHPNIAGELGGPSRPKLFSFVVFLALWLIYIVYSSLVAYCMMPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTT7</accession>
    <name>A0A914GTT7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTT7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11283.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11283.t1"/>
        <property type="gene ID" value="Gr19_v10_g11283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46679">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46679:SF1">
        <property type="entry name" value="GLUTAREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11283.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13714" checksum="855C7C21C9E8607B" modified="2023-02-22" version="1">MGGSSSVPESIANKVNEEQIRKEVGEAPVVVYTKSGCGYCDLAKELLGRERIHYQEHDLAQKEREDPEEAKRYVNGLVYVSRHKLVPQVFICGNFIGGYTELAKLRETNLLRDEILRCSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU14</accession>
    <name>A0A914GU14_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU14"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11204.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11204.t1"/>
        <property type="gene ID" value="Gr19_v10_g11204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11204.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30515" checksum="A98EC8AD0EE8A3C3" modified="2023-02-22" version="1">MMSSVRHHHYHNLNHAVPSSSTPSSSSAFRRHPQSASSSRSFVSSPNFYLQYSASSTMSSNGDGDFLWLGLLLVIMAVVMLIVGAVWSAFFCHSALPLDGEIRNEERRRKRKFCWRRGRMMETMCRCAVAGSGDGRNGRQSTKDSTDSHEKKAHAVCLGLDGSGNFIPEVAACSEFRQHQPTTLTQCQSLQQRPQHLVVTLERPPTPRPESFRRNSAQAAYRLWLQNKFEKQFAQELMQSQDGQYVQLLVEEPEELLQIACGSHGFPAGDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUC3</accession>
    <name>A0A914GUC3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUC3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10865.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10865.t1"/>
        <property type="gene ID" value="Gr19_v10_g10865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10865.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25838" checksum="70F4F6F90E281596" modified="2023-02-22" version="1">MTSTNASLPKVSYVKSLDIFLGVCFFIVFASLLEYATVGFLMKRQRQKISSTSSSVMPRSSTVCFRELEDGTLKMMAPLHQNQPYRTPRERKPGLRRQASATPLARRLSTVITNGGTEITGIPLFNLHPHAATMTASTGPAAATNTGSYPNSNHRGASRCSLGFFGPDEAVMFALTGPDGRLSAAAANASSSRRPGSCLMVRPSQVDLFSRIAFPLFFLLFHLAYWSFHLAYLQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUG1</accession>
    <name>A0A914GUG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11305.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11305.t1"/>
        <property type="gene ID" value="Gr19_v10_g11305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="712"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11305.t1"/>
        </source>
    </evidence>
    <sequence length="824" mass="91750" checksum="C03BC410EEEE877F" modified="2023-02-22" version="1">MDYLQKIRSTVAAQVHSVAAQVSQALPGNPIFREYTIGPQIGSAGPGLCWKIFNGVKNTTKQEVSIWLFEKRQMDNWAPARREEFPEMLKRGVSQLTRLRHPRILTVERALEESRDCFAFCTEPIFACLANCFGDLSNISALSHLKEFELLDLERRHGLYQIAEALAFLHNDTKTVHGNVSPSSILVNSKGAWKLGGFDFCILGNTSTPGKVNFNVPAWSQNEVSAMSPDLDYVSPELAEGVRCDTFVDIFSLGVLSFAAFNNGKPLFNSNNSFGLQRENLKKLKQSLQKLIAIVPAPFGEDVKMCLNETPELRPDAIQFTKLAYFEHPLLKTLNCLEQRSAMDNTQKMQLFKGLPTILTQFPKRTLLQKVFPHLAAEFATPMLIPFILPSVFLLVELISPKEFASSVMPSLLTVFPIQTPYQIALLLMQRVNLLLEKMPTAAVKQHLLPLIYNSLTGDNARIQELTLAEVPNIVKFVDREQMRTQLLPKLLRLVLESRDLSIRVQAMVCLAKLLPHLEPWMVTDQLLPTLPKITSKDPGVLMAVLGIYKIVHESDKFGINKEQCARSVLPFLISTSVEPTLNLQQFSQYIELVHQLFRRVETEQRQCLEQLSASQEKQRKITDFADFLNAQSSVRKTAGSLAVEGADVTAKATLTLEEKRRITAEKNGHSIEAGKTATLDPFSALSTRQSLQQRPQSSLGSSNRMDLLLSEFLPPNSSSAPQTSQQQPHLPQSASFAAFPSIPQPNSSANPVQKRGCVGVRPSAAPKDPFDVLDQLMMNATGTEPKPNEAIGRDEMPCTNGGFASRGGHPNKVEKDPFEDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUV3</accession>
    <name>A0A914GUV3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho guanine nucleotide exchange factor 6/7 coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11408.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11408.t1"/>
        <property type="gene ID" value="Gr19_v10_g11408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032409">
        <property type="entry name" value="GEF6/7_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16523">
        <property type="entry name" value="betaPIX_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Rho guanine nucleotide exchange factor 6/7 coiled-coil" evidence="4">
        <location>
            <begin position="457"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11408.t1"/>
        </source>
    </evidence>
    <sequence length="542" mass="61313" checksum="723A4B21C15CE862" modified="2023-02-22" version="1">MSNEMENQRKIEQLMSTLKSLAAAEKGCEFSSVIKSLAEFIALKNDVLVLFEEQTKKPLNSQFLGKIFLDVELRTILFTYCKRHCDLMDFLNRNNEAVQKMISLRNIDLKEMVVGLSLVFRHVDKYANILQEIERNTPDGHPDKGNLYRASLVYADFYAECELIRKQREAQIYFMHSEILEENFGKDFEHLLGPIFYIGKVTVTESDQMEEGTEEDRCVAIFGRALLLVKHCSSTGKIVLTNRFTSENMSIQRENSSNSIHINMSSEKEVKFTLRTIGRDEYKQLLNALKNCEGIQLGHDDGSAFNLNAVQQPNTVGSTDGTSIATGFCNIRLDHQLEMILPGEDFSENVVSEVSAPSVRDKLFSGWSLRSYPPHRAEWLPNVGQTAPVKLRKGLSAEEQEDALMLKIIEGYCVTGASSASASCNRRAHDQRNSAESFHSPCGGASYPDQHEMSNRPQLIVAEDEKLFVEELEGDQFVVRERSLVDTVYSLKDQISVLTKELSKIAKALEQEQRTRRRLEEMVIRQTATGTVKQQNIAADPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVF0</accession>
    <name>A0A914GVF0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVF0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10755.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10755.t1"/>
        <property type="gene ID" value="Gr19_v10_g10755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10755.t1"/>
        </source>
    </evidence>
    <sequence length="772" mass="84671" checksum="1A1CF1A1B9019430" modified="2023-02-22" version="1">MSGSSSNTEKKDKFTEFSEHAHHWTLKQDNELKNALQNTVSGMFDSIQHFERVGAALESEMDLFETRFENIRNRIGCLKMERLVKEQVDDISFDLLCGRRHKTMYREQPPNISREEFERRTINTISNAIHRGFELFNAVQDDHPQRNLQSSSGLDPSDPSSSSSLGMPPSKSMDGANLGELPPIIGTPEFYAALRRANEAKTESATAKAVKELSMSPPTTMTTTKLEEEDIASISSGRSAPPQDPVVVVAELSPTAATISTGGGGNAGHSLRTALMEEIVERAQRKDDSTKTEEEEKKQRIGVTQRVREEKLRTEEEKRKKMPRAEEKQGTEQRRHVDESGEKQKGLRIRNAEQRQRTEGERERIGGETEEHQKSSEGQQKGFQIQKPVGGNPSATANGTPKRMGGRHVKKSLFSSSSEDGDNDEEELFKNSTKSLRPVVGRHIQRQTLANDSSSSPSTNDRSLSQRPLSAHPISPSGDGQLPPARPVRKTESAVISSNEELGPASVKNRIAQIGAQIPLGQRADGGRREEGHRHGDGGGQISEPTPAITKTIVPLPTEALKTRVKGPSARRAPSQRIVGGRPPAPSSSSVVEPTEAVTEASSARLTPKPALKKGLESPQQRQKNEEEKESPSSRTANLWADDSMKRALERMSKDYVDEEADHQQTSRIKPPPVPATKAQGPKTAAKAVPPPVKPKKTRSSIFSSSSSDDDLGFAKVMGSTPLPGTKEVPKATAVPSNQQQNKQQQPPFSYKKTTTSVKARKGLFDDSESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVT6</accession>
    <name>A0A914GVT6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GVT6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11654.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11654.t1"/>
        <property type="gene ID" value="Gr19_v10_g11654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="433"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11654.t1"/>
        </source>
    </evidence>
    <sequence length="635" mass="70560" checksum="4F571EC0D631D7AC" modified="2023-02-22" version="1">MSKKASKNCWKLRKMDYVELGDESSHAIPPEAPIFVNVRDHFAAWGKTLVRQFAKPANGPRRRVNVTLPPNPSNDQLNNCRGNGKSTLTHFPSTDPDQSQPDPGGLSTYGFEFGEISRIAFRPEYKIACEQANVLQPKHYDGNAFFNTTVTYRTDSTVFMPYDSLVELQLAPDRRKMDEGGTNSSLGRMKHLLDTGNGADVHFLVGGGDEKELMPAHKTILMAASDVFGAMFPFDARNAETKPVEVPDVEVGAFKAMLSFIYVDDVSGLNGDNAIAVLYAAKKYDLPELVVSCLNFPIWKLSNVFFAFGQTRFLGEGHIDVNADALILSEEFLEIDQKSLCEILDRDELMISEEIAIWNAALRWADEKCRQNGKEPTAANRRAMLGPALFKIRFPLILHEDFSDNIVSSGVLTEGELISVFLHYSRPDRARPEPYQLQFPTNGRAFTGLTIQNRWDSAACHDLALIGPNRLSVQITADNPMYRSVLAIRPIPKRKFGIFYYEVTLVAQKGFVSIGLAAKRMPLDKWVGWYKGTYAYSRWGDFWGHAVEECSHGRNGRPFIAGKPKFGEGDVIGCGVNLATRQIIYTQNGQRLGTAGLCVDSAADLFPCVSLYCSGDKIEANFGPNFKFNIAADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWC5</accession>
    <name>A0A914GWC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11942.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11942.t1"/>
        <property type="gene ID" value="Gr19_v10_g11942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056710">
        <property type="entry name" value="DUF7808"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493">
        <property type="entry name" value="PROTEIN CBG13422-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25096">
        <property type="entry name" value="DUF7808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502421" evidence="1">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7808" evidence="2">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11942.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20146" checksum="C4A8C9750D5C69D4" modified="2023-02-22" version="1">MLPSLNLSLFVLTVICIPLQFIEAKLGHKQQRRPSYYWSNRQLECANHGLNISRCSLREEGRVSELNPGCFDEIDTTNQTRVYCRLNCEEADETTVLRKEPSNNHICSAYHTYNLERRRRDWYIWRVGGCISTTITFALRCGFPSDPRVFYAKHKHLFEHEEFNGTAAGKRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWM5</accession>
    <name>A0A914GWM5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWM5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11433.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11433.t1"/>
        <property type="gene ID" value="Gr19_v10_g11433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11433.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9410" checksum="B17F402D910322D4" modified="2023-02-22" version="1">MSFTGALEILNDSRTFPVPARPPGQTEVEFSCLIQNCLRDLEDEDKYTREITAQIADPIDKWMALRTNMTGAERIQGGQHTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWX8</accession>
    <name>A0A914GWX8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWX8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11927.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11927.t1"/>
        <property type="gene ID" value="Gr19_v10_g11927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037770823" evidence="1">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11927.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17305" checksum="68ABA9A10A4DB16B" modified="2023-02-22" version="1">MSILPLATLLVALALNIHSLNALSRRESGLSNVETAEKKNKLNEEFNRKFGALREGCFPRPKGKGCRCTVKGLLGHDEEKRFDRDEDCLRPSQNVRDPVREKAQQNYAAVLDELKNKFKGLKKGCYPRPKGCLCVETECKCQKGDRSPQCPADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXL2</accession>
    <name>A0A914GXL2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXL2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11703.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11703.t1"/>
        <property type="gene ID" value="Gr19_v10_g11703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11703.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17108" checksum="1FD4614810B87569" modified="2023-02-22" version="1">MYCLLLLFDGEEKEDGNVSSVEHFRLSEHHRLDRHTHYGQFGVRLNAKISRMAGFLRDRIPNKSRGTNITTFACDASACLAILKKPSSSAGRRAIATITRNFVSSAAEIGWRANHIQNGAGRELWILPDFPPPGHSLFDDGTPPVTHSLIAKSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXQ2</accession>
    <name>A0A914GXQ2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914GXQ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12151.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12151.t1"/>
        <property type="gene ID" value="Gr19_v10_g12151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="103"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12151.t1"/>
        </source>
    </evidence>
    <sequence length="472" mass="51631" checksum="1F96056574D8368A" modified="2023-02-22" version="1">MKKLCRRLSHALPAVLTWSLIGGCSAAFFYILVPALVVQLGLAGYFLCSLDIVLFAVCLSNLCLSTAMDPGIHPIAISSEESGVDDYRSPLYRNVEINGITVRMKWCVTCRFYRPPRSSHCSVCNRCIDCFDHHCPWVHNCIGRRNYRYFFLFLLFLSFHMVCVFGLSLSYTLLSRRDILTRPNLCSIVLMSLCALLAVPVLGLTGFHIVLVMRARTTNEQVTGKFRSGFNPFTAGCWANMGRALCGSQFPAYQQPKRVKKGGGRECAVIYVPEPCESKDGSIRMKRAGAGGESSASIGTALSLRASQFGVLPQRVVGGDAESSRKDDSRCNLFSGDEDDGDGSLADRPKCSATDALVRKSEHCLRSAYEQSVREAVAGKRLPSAVNLAAPLLPHSKSTSDGLAEARMATKSPTRSSFSVLPAKGRDVPNLRVSNGMTQQSKEGNGEWRSGRGPPLKFTEAVKMHDDLNNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXV7</accession>
    <name>A0A914GXV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g122.t1">
        <property type="protein sequence ID" value="Gr19_v10_g122.t1"/>
        <property type="gene ID" value="Gr19_v10_g122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037641893" evidence="1">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g122.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="20356" checksum="154197CBE193C452" modified="2023-02-22" version="1">MCHKIRLPSVQCALLAALLFGANQTLCQLLGAPGGCATIAMLNAQQPGASPQAPSFQQPFAPSFGCPLSALGAFGRQFPPPPPGGAGGQFPMPGQSAGNFPVNVMNPNFMGTSSQPQQNGGGGAVAAGGNNNFGTNGNNCNCGPCCSDGGGAANSFGMPSTGGGEFGGAIVGAGLNNINNNVNGIAGGGTIDMVNGGMGVFGRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYD5</accession>
    <name>A0A914GYD5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYD5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12290.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12290.t1"/>
        <property type="gene ID" value="Gr19_v10_g12290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12290.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41845" checksum="F34A4F95EEA516EF" modified="2023-02-22" version="1">MSRTLFSAGTLQSRYTSEPHTSVSVHFRAAHFSVGTLQSRTLQCRYTSVPVHFRAAHFSAGTLQSRYTSEPVHFRAAHFSVGTLQSRTLQCRYTSEPHTSVPLHFSAGTLQSSTLQCRYTSEPHTSVPVHFSAGTLQSRTLQCRYASEPHTSVPVHFRAAHFSTVTLQCRYTSEPHTSVPVHFRAAHFSAGTLQCRYTSEPHTSVSVHFSVGTLQSRTLQSRTLQCRYTSEPHTSVSVHFRAVHFRAAHFSVPVHFRAAHFSAGTLQSRTLQCRYTSVSVHFRAAHFSAGTLQCRYTSEPHTSVPVHFRAAHFSVGTLQSRTLQCRYTSVPVHFSAGTLQCRTLQCRYTSVPVHFSAGTLQCRYTSPTGLNLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ44</accession>
    <name>A0A914GZ44_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZ44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11730.t4">
        <property type="protein sequence ID" value="Gr19_v10_g11730.t4"/>
        <property type="gene ID" value="Gr19_v10_g11730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="197"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="313"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11730.t4"/>
        </source>
    </evidence>
    <sequence length="575" mass="65522" checksum="3AAA5617D46568BE" modified="2023-02-22" version="1">MHRSSVRHDTIIGVCTTARRFSRPGCRFRLFHQKVRPITGLFENILVGREYKDLKIFSLTMSVKIECELLETDQQQQRFLQDELLLMGEDGNSAELLKPIAFCNGMSQQRQITEVHLQQQTLSATIVQNGMHGMPCSSTASSLLTSTPLTALVELDGAGISSGELHLHRPEGSDSSAGSNGTGSKAQPRQRRKVPEGELCAVCSDRATGYHYGVASCNGCKTFFRRTIVSEHSFVCQYNGNCDVTKNVRCACRHCRFAKCISVGMDARAIQNDRDRIGPTKRVRLSSGPDGKRSSMDEDQLSMSSLSPLTRFQDDKLVEHIMTIEDLCNVLRNCVLEEGKGVHETLAQPSLLYQARNMPKDVNTMYRELYPASMNDIQMWNIRELRLCLEWAKTFEEFQKMSLADQFTLVRHFAFTFNILNRVYYSLDYGPDKIVFQNGAYILRQPQESVKIPGCRPIYHRQMDEIMLPLRKLDISMKEFACFKTCLFFNPDVCDLSPDVRPEIGQERTKYLSALFHMIVERHGAAFGIQKYGNLLMMTPSIQNIIDQNDENMQVMEVFGHFWRINGFVKELCMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZK1</accession>
    <name>A0A914GZK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12807.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12807.t2"/>
        <property type="gene ID" value="Gr19_v10_g12807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12807.t2"/>
        </source>
    </evidence>
    <sequence length="185" mass="21270" checksum="E2B0C450AA3DCC80" modified="2023-02-22" version="1">MGNRRRALETRRSNRKKGTVPEAKAKKRWHRVRRSSVSSSVSVRLQLHFARCSRSTKWGTTADDQTDSYSDLSDLDVFSSSEGGDESADHHQQQQQRKKNAHEDGGGVKATGEEKKKKKRHNHRQQQQHSLDTFITAAFAHRDLTPPELALGYALRQHCREQNDTANKRYYVFPRAGRVFERLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZN3</accession>
    <name>A0A914GZN3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZN3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12284.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12284.t1"/>
        <property type="gene ID" value="Gr19_v10_g12284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12284.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14852" checksum="1FAE1D9B90365739" modified="2023-02-22" version="1">MQPRRAARCGARVADAYATRCSFAAGAQCCPIGVGVREEKSEGEEARESAKISAKRESAKREKRENAKEETVPKEKIKSEKCHKMKLPKGEMPRGKSQNQGKCQAGNVPKGEKVKREKMPRGKSAKRGNQEGKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0N0</accession>
    <name>A0A914H0N0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0N0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12952.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12952.t1"/>
        <property type="gene ID" value="Gr19_v10_g12952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037585849" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12952.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10059" checksum="1102739B5DF9229E" modified="2023-02-22" version="1">MRLFLATLFILAALKSQVMGRAVEFGSDLANTPPIFNTYKMAREPAYANELWHFYDPSGNNGALNDDNLWSTALSRHLLFHMNRKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0X8</accession>
    <name>A0A914H0X8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0X8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13015.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13015.t1"/>
        <property type="gene ID" value="Gr19_v10_g13015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13015.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27201" checksum="B9BF982EC47347FC" modified="2023-02-22" version="1">MHYFLLSRAYCSAKASPLALTQELVSRLERLSALRMQLPDDARNLTDDIRLAERIFNVDTKGVNPLYNVSEDCISCPLRNDVPGPTSMNETLANARKTFEGKMAARTRTIKQLMSGPLVRVACPTNRLLNERTEYGRRMKRLSHRIFGEVTLQADKKTMRVAEIMAAEPWEQQAKLSEKYYPNTPMFHYLVKMLKMHGLFFDEHLVWREVQNEIRIAKGKIIHPPIGAGKQKTKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H179</accession>
    <name>A0A914H179_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H179"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12309.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12309.t1"/>
        <property type="gene ID" value="Gr19_v10_g12309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12309.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25010" checksum="40EE8AB85B5099B6" modified="2023-02-22" version="1">MEERVAKLELENKELRTKLKECQKQQQQNIDALKRNGLTPQNRWNSAACHDNLALSELDRLIVQLNGNNYEWRSVLAVEPISKEYFGIFYCEVKMLEKSGYAFIGFATKRMPLDKHVGEHRGTYGYGSYGTFWGHELEGCSRNSGRPYINGKPRFDVGDVVGCGINLATRQIFYTKNGERLDTANLFVSFSVDLFPCVSLRGSNDKIEANFGPDFKYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1I0</accession>
    <name>A0A914H1I0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13154.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13154.t2"/>
        <property type="gene ID" value="Gr19_v10_g13154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011061">
        <property type="entry name" value="Hirudin/antistatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938">
        <property type="entry name" value="ACP24A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938:SF11">
        <property type="entry name" value="WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57262">
        <property type="entry name" value="Leech antihemostatic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51252">
        <property type="entry name" value="ANTISTASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1558"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="12">
        <location>
            <begin position="429"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="10">
        <location>
            <begin position="491"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="11">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="10">
        <location>
            <begin position="819"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="12">
        <location>
            <begin position="1070"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="10">
        <location>
            <begin position="1123"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="9">
        <location>
            <begin position="1369"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1630"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1651"/>
            <end position="1670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13154.t2"/>
        </source>
    </evidence>
    <sequence length="1709" mass="185956" checksum="3098B2509A4F361A" modified="2023-02-22" version="1">MKDVGEVTPTESFAFTAFSASSSAPCWPKSFQMFLSGSSSVELALFLFFCFWPTYSVSQAEEASLPQLLDSLEGTFNVLRVHRAVPSAVQEAMRERWVQTDACCASANVVLPSRQRLTYGLLFCRPDERCTSQNGQVGCASPIASNVGAGSGTVFVSPTLQQMPHAALPVNVVPLRPFLPIRPLQKPPPADENEAKYLGAGKSETNFPRGEEWTTGGGGWDGGDPCEGVTCDESPFHECQLVESDCGDKTTQKPKICPPVAKCLINPCPRGTPLRLPNSGVTALCRRDGQCLDGWCHKIGYNGLGFCCPLPVPSQIKDGRCEGKQTTKRMMAWEPRANCSAECRAEERKQSREEGEGAITQNTVKKPSAECPLIREERIQQLFYTIPHFSYIFDGCSLRCTRRTSSIPSNASLSLHNELHKKAEKIAEGSPVSGECPQWPSAFWTQFCPEGQRENGHDECEGEDGHCPSGLKCCVGPCNHRFCLYPSLEGNSECVAQSVAFRIVAELNSDNKSIFEPKCDAKGQFAAEQTDGDFTFCVDERGKELAGSRRRSDQFIGCDQKQNCPSAQCHLKCPFGFQFGSEGCPQCKCRDSPCHAVKCPKEMVCKMNPYNCRISPAKGQHPSTSKSNCAVPECLPNVCMKGEPLEDALSGQLVQCNERDGIKCPPGWHCHQIGIGPMGFCCSGMLLQSELLPSSNQCPTVPNLSYKLLKRRQSERILGCRLSRECPSRQICCFDGASTRCLALSEKGEVERSPVGGHQSELSPKKVRHLGECPFRLLNASNPGCASNCASDADCARRSPFLRCCPVGCGTQCQFGDKLTPCVHLLATTLREVDKLVEVPKSIGRPTVQCNGEGHFEKAQFDPMNGQFWCVDPVTGVEAVGSRISASPLGPVNPPPDDCSLRHFCKSNCSALKGLCPHGLRMDHRGCPLDEQCQCRNACDDFKCSFPDKEICLLKVVECVDEAICPPIPTCVQNVCQRFGVQSIGNFVCSNSAECQKKDGNPDRVVECKFGPSNFTLDRIGICCASPLGRLFKEQSLSALSADLSSSMSAGVDAFTGKTLSKVEGVSGSGGRRQGLCPAIDAGGVGEGDCSHVCSTDADCAGIQKCCPKTARGCRQCVQPLLTTNCQNLLSAVLSLDAARIQHFVSKPNCNSKTGAFSRVQCDGQGWCWCVESTSTGFPLSGTRLFQPMDGEMFCERPKPCPLEQCPANLCPFGVEVDLDGCPLSSECRCRSPCDQIKCPNGQICLLWSRNCLEAEQTPAEVFGRTVGICLPVPICEQSPCGGILKPLLNLALLVPQKCQLDADNGPISLPQCPAAFQCIRQRENYSVSTAPEGICCPGEKFVGDGAVESEDREQQISATARDKGANFCYLPVHQGSGVEECGMGRSEMRYFYDLKTDGCEAFLFAGCGGNGNNFKSESECEKKCQVVANRRGNGAEGFEVGFVLDEIGHSRRMESSLRDYLRKAFALTEGQIQKVRMDEPTKGQVHFTIVASDARQKAKRISETLALGQFQFPHDGIVLRARSNGWWTKRTTDGGEGEGDEHGTDAEKMEMGQHFPLFWVLLVSVVIFALVVLFIPCCAFVSVLSSPRVRALGQHNWSPMTNARNDGISTTPTVLMEESEDRVRALRTRSSAVGGGMPSQPPREDHLPMPLAVAPSSPSPAASSTASTHLAHRQRIIAPRILTEEGGETERIRRGERTSVRSTWRWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2H9</accession>
    <name>A0A914H2H9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13536.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13536.t1"/>
        <property type="gene ID" value="Gr19_v10_g13536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05511">
        <property type="entry name" value="Bromo_TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000066">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1519"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1641"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="967"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1160"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1217"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1746"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1784"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1841"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1589"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1160"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1217"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1254"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1784"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1851"/>
            <end position="1860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13536.t1"/>
        </source>
    </evidence>
    <sequence length="1860" mass="209607" checksum="DC15A0369CD1E44B" modified="2023-02-22" version="1">MDAEELSGPSTSSGCTFIPPSQRGDAPLAGILPPEFEDIDPKRFFPDFEQDGILRFSRVFASNTKPTMKNQIWWTSRTFKRDNKKAAAAPTSDDKCAQVEEAAAISTIRRPDAEGQRGDGEKLEKEEAEQSQATEEEEDPWALRFGPPPKKEDCCTDEYELLCAENLDELLSSKHQNQTNEDDDEAAPPWRFGPAQMWYDRLGVPANPTNFDYGLKRRGGTGVKASSVNETDEGMLSGGEDDRDFLPVNLLHWEDDIIIDPEQAREKLVKELSSVKLPRCGWIPTPYTRNYKAFMTAWKNKSFIEYLLNPSLSRYSTPLNNSSDISDSRYLVDSQHSLFPFDNYELENTRWEDDIIWDSANMPTIPKPRILTLDYEDDPRAFGMPEDTAHAEDVLQQQHQLGGSRALGKDQGVMKKSKLILAQVLKRQRQEVEEQIETQIAQIADKDPFNLSNDEYYMPKSSGGNAKTQRSLANLTVQHSLPAQNLHPALFPLLQHSAAVQLRHFHRVPLNRRAIQGMMGRNMPVQSLMRHIRLKSKEHQHLADRGGGFELFVMRELHNLTGRDGTLVAMEYVEEHPPLLNQTGMASKIRNYYKKKLTKEEEKREFEFGETAFSHTSPFLGDLSSNESVQAIENNMYRATVFQHRPLNTDFLLIRNKYGLFIRPFPALFAVGQQLPLYEVPTPNSKRAKDFNKDFMMSYMFRLFWQSEDLPKRIRMDEIKQMFPGQEGIIRKNLKQCAELRRIEGHEYWMLREDYRLPNREETSNMVTPEMYCAYASMLAAEQRLKDAGYGEKYLHVPENADDSDDQQNMEDEIKCAPWNVTKSYISAMKGKCLLDQSGIADPTGADLGFSFVRVSTKPQKPPKEEVEKDAPKKLVTGTSADLRKLSLKEARQMCREFGLTDEEIGSLERWDVIDVIRTMSTQAAQGSTDSQVARFARGNARATLADMQNKHKEHCQRMFERQNKWLRSSASADAQQQQQQQQPTSDEEWRRDESDDDDDDDGRCGGGRGKKLYSTTVTLTHADKRKLEFEREERERLDLQRMIRGEVTKGGSSTVSVAAKEAVAAAKGHTESHAATDGPQDAFTVPNPQNSVSNSLLNTTANEAQRKLRVYRIIKNRDGTESTRIETVSHPQLIEAYVRIRTTRDDNFIKVYAQMDDQYKEEKRKERRRQQQQEGARRSKKGGGAGADLKSTQRQDNNIAAAAFVKSVLLEQQQRQQQQQQKQEQQKELTASATTMAATPSPNKPGPKPKMKSPMEKKQRKEKPPPPPPKQKDLKITCSACGAIGHMKTNRNCPLYGKDEDLASKTVGEICQPSTSKLSDVPDEEGDRLPSGELIEVEGTRLKISKKLYKHAEKERKDALRLHIPRKILERSLKKKKKLKKANKEAAAAAAAAAAATVVAPTVAEHPPEQPEPKAPTLAVVEDQSVPKARAPLTLSISIASLVTTSVQVGPLSAISSTSSTGGGGGVLSSTSTGAMKRRGTIEEADYLMGPLKSVHRRRADPRVSMASVLMEILNELKNIDGSEHFACPVNIRKVPDYLEVVKKPMDLQQIRKNVSENKYELRRQFLEDLTQILANSITYNGPGHPITEAARRMLEHATKRLEDSEQKLIELEKQINPLLDDDDMVGFSHILQQIVQECKNLPKSAAFHARVDPKKFPQYNDKIQRPMDLGTIEQNIKDHRYTTVNAFRRDIEQILINSRIFNGAQSAYTLKAEEIVEVTNQLHDKSKGHLAELEANIQKALSANQDGARGAEAEAEEGAGGAVMLQQQQQQDLVALNDQNTEGEEDEMLMDEEEMTKVSDEEETGTGTSIAAVAEQMLHQSAMHTSGQLNADLALSDSDDEQLMSAKKPKLDDFDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H379</accession>
    <name>A0A914H379_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H379"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13236.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13236.t1"/>
        <property type="gene ID" value="Gr19_v10_g13236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13236.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12676" checksum="3EA45CC9D581C9D2" modified="2023-02-22" version="1">MSKEPKSAIWHSNYFKRNIDGDTLCILSSTSTPERQQKRKFAEGPPFSDFFKARLCPSNVVTEQEQNLARLVARPTTPISIVESDEFIKFVENYDSRQFLGNGRSANSPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3V8</accession>
    <name>A0A914H3V8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3V8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13405.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13405.t1"/>
        <property type="gene ID" value="Gr19_v10_g13405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF20">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 9" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13405.t1"/>
        </source>
    </evidence>
    <sequence length="612" mass="68558" checksum="E96E70D7290BDD87" modified="2023-02-22" version="1">MPIKWFSKRRKAADEELNSDENDKALEGKNQKGVNTPEVEPSTELSAVDAESVDRGQWTGRFDFLMSMVAYAVGLGNVWRFPYLCFKNGGGSFLVVYALFFIFAAVPIVIMEATVGQYLQRGAMEMWKMFGIGNVVIAFMCISYFCVIVSWALFYVICSFNTTFPWETCDNPWNELNCYTGKENITAGERQEIVDVVNATMPNGTMLQSSVEQFWERRVLQQTSTIDNFGGIQWELFGLMFLAWVVVYFALWKGITKARKFVYFCALFPYFLIAVLLLRGLTLPGALHGIAFYLTPNIAKLTEVTVWKDAGTQVFYSYGVGFGTLIALGSHNKFNHNCYRDAILLCFINGMTSILAGFAIFSTLGYMSKIANKPIADIVKPGVGLAFLAYPEMASNLPWLKQLCSVLFFLMITILGLDSQVCMMEGLFTALEDTFPTLLRKYKKLSLLITCIFFFILGIPMVTHAGAHWLTLVDAYGASGIALLFVVFFEVVGLAWGFGAERVRDALKQMIGKYPLPCFIILWKYTAPLSAMILFICCVVMPESLSYPSGIAYPIWAQVFAFCLSGCSMVVIPGYAIYYIFFSGHDGELTPLQRFRKGIHPPQELDVADTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H491</accession>
    <name>A0A914H491_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galectin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H491"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14008.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14008.t1"/>
        <property type="gene ID" value="Gr19_v10_g14008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037264260" evidence="1">
        <location>
            <begin position="24"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14008.t1"/>
        </source>
    </evidence>
    <sequence length="928" mass="105204" checksum="E48EDECFA8972DB3" modified="2023-02-22" version="1">MSFIHFLLVILITCAPLLHLADGQHTPTTPIHLTGNNQTSTVNIFYNDLLQCMPSYTGNNAEAYGLEFRLPRDAGHCDDGILICYPSTLGTSRMLVMSGQFRIPNTEQMLFVEECKALVTAENDKCARKFHWRGIKVYTMPPINGIRTHQIMLEASIASRPYNFGNVHQIGVHFGDRDQIATYATVEYGKQAYIDDQLLREAFLEKIVHGERLKNYAGLWVLGMDMLPSTQLNKLHHLYINRTCTCTMEAWFIRPTDSVAKIVEPETPIAGSKKCPSLNTNRTFMIGLIDADEQAIVIDALTDVDLKNMTVELSKTDENNVTGGPVLMNFTIGTTDELKVFLPETALIVTKDERLPNGSYKMHMEIILFKHFYAIKLFINGTQLGGIFLSKNWFRGIEWKNRSIKLTLNGQMMLFDEPKVTEINDPVKSILEKSPVGLPTSFTIDGHQNNLNFLFRFQKRNSQTTSTFSIMFSKVKRPIKEPIPGTAFIIQFELQDNCYNVTLKVYDAGKRTFDEEENATRICNKSNAFEFRFVIKHVMLDGNVNLLEQHFMSSADAVKKAKFVYALNNTLLNYGDKIILRGTLNPISDIIKIYLQNKDERCSKIYSNVAVLVFEINSYNPIICWHHLRKEAAAGLTPNVVISGKHQIFMRPYAETTLQILMAKDGFYGEVCGNVWNKLCPYYNPKNINISTMPIPPWTIDHITVNSSAFDTLKIWVEKASSNANDLFLYGEEHGTNFVPWKRINFTQVIKKGAAPGYVVFVNIAFKKGLKPDSEVRINFFNEALEFHDLFGATVFRVTLRKNTLWFKSVIKQNNSFIYDVDRKMGAYNDVTTTSLNSTIDQEKLLPLNLSFKIFITETDGKAEFEVTLDGLGKIASNHGGLKFSFPPNVYVPVIQYITVEYGNVTLAAGSAELEMLCSENVYCFNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H505</accession>
    <name>A0A914H505_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H505"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13293.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13293.t1"/>
        <property type="gene ID" value="Gr19_v10_g13293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055577">
        <property type="entry name" value="DUF7153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23672">
        <property type="entry name" value="DUF7153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7153" evidence="2">
        <location>
            <begin position="75"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13293.t1"/>
        </source>
    </evidence>
    <sequence length="495" mass="57033" checksum="56CB799765848E6D" modified="2023-02-22" version="1">MRKKSFCRHFLVLTFANASQFDHCQPSPFERNWQQTPLNFGDEKCFGHGYSDCNLLSLRRWKSVRSPSIDAHSDLTLHKFVDLSFFDVMFSSKEMPSDFLDTNQNGEFWQLDSFEKGLYEELKTVKWEGLMPEESDHWMSDSSDQPADGRDEGSPSSIWGEYSTTAGEKNTEDRHTDNSGYILVGHPSGSHQQPTRPFVSDWHNWSSVRNLCATLPQKCTFRRLSFYRKRNGKCRYEFIVLIQVDNVTSFVDQISNCINKVQSLPEKRAYIDLYQEIEFEVDLEVLQHLVEISKSINCVGRRLVVQFGDDHSTDTFALTKQTPFSLYNRGNFCSSSNSPSISISNDLTLNFANNNYGSDEEKSEASEFDVEMEEIMDRDENQNVTVKQRHKAESEEDVTNNNNLWKNDWKNSRNMVKHLFTISTPYPQQPAELLQLVEGHLNNEKMAGQDVVRNSMCGEKNRNGGTSGRRKGGRTLGQKFIGTLWRKLSTKQERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H511</accession>
    <name>A0A914H511_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H511"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13728.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13728.t1"/>
        <property type="gene ID" value="Gr19_v10_g13728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13728.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="12013" checksum="09F4C32B45EB509B" modified="2023-02-22" version="1">MEMQQLELNLPTSSDSNDSENKSEIPLHSKESVAFYRDPYNKPELEHTLRGAELVLFVFFYILGLCTIVVLLEKLMPVVWTDEQHFLEQRRREEIFNRQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H944</accession>
    <name>A0A914H944_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H944"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14396.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14396.t1"/>
        <property type="gene ID" value="Gr19_v10_g14396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="280"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14396.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42339" checksum="A7F70E97A712012C" modified="2023-02-22" version="1">MPSPGPRPEFKAQVPGLVPNSKPKSWASSRIQSPSPGPRPEFKAQVLGLVPNSKPKSWASSRIQSPSPGPRPEFKAQVLGLVPNSKPKSWASSRIQSPSPGPRPEFKAQVLGLVPNSTLNSLVYMRGLFELRCSPPALDQRQQRMEELRIVDEPTSNQSISIIVLLFTPVAFSLRRGESTPNFGLSRDKSAKRLVLMLNKIDLVPRENLLKWLAHLRQQLPTIAFKASTQEQNKKLGRYQRTLPNFEFVQHFSAKCIGADLVMKLLGNYCRNKDIKTSIRVGIVGFPNVGKSSVINSLKRRKCCQTGALPGLTRQVQEVELDKHIRLIDSPGVVLAPKGTLNDAAELSMRNAVRVAVGPDQSGQSDSPSMLHQNVDAPLWHSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H993</accession>
    <name>A0A914H993_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H993"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1444.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1444.t1"/>
        <property type="gene ID" value="Gr19_v10_g1444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1444.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19065" checksum="3C3F7E9E48727AEF" modified="2023-02-22" version="1">MHFFAPLLPNLLVKTIADFSPQSATRGEATTIKKYKRNALQAPRLADERTTAEIYLRDATSPPPPYRRPTNRPSTNIVHPRPSSTTPSPSPSRSPSLTQQQQQHQYQQHHHQQHQQQQSESMLGDERRIDGVRHVLTAQGIEQEQEQNRPLEQENTSHVGVTICVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAB5</accession>
    <name>A0A914HAB5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin-related protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1524.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1524.t1"/>
        <property type="gene ID" value="Gr19_v10_g1524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1524.t1"/>
        </source>
    </evidence>
    <sequence length="623" mass="71362" checksum="A08408AB45750ED4" modified="2023-02-22" version="1">MDQQDIANLRIRTLMEEIEGKLLQIRETIHDLLMSLELQEHVQWADMVQKFCSLSGMFASLQQIMRKPDHNNMDDNVKLMKMTQFVPKNVSLELDANLTNFTDGRLPNFGHNIVPILLRTKLKPEVEEDELNIERERSKGDIPKQIKTLNSHIDMLCGKLADFTKLNVMDRLEAPSYSEEETTRLVKAICLGNGINPKAHSRNSQHQTRSRGGSPFVFQHLRELMHTNLPAVVIDCGTGYTKLVKDANILKNVGGKIPDLDFFIGDEALSPSAANYFVKYPIRHGIVDDWDLMERFWEQCIFKYLRAEPEDHYFLLTEPPLNTPENREFTAEIMFESFNVPGLYIAVQALLALAASWHSQDKNQRSTTGLVVDSGDGVTHCIPVCEGYVIGSCIKHIPIAGRDITYFLQQMLRDRELNVPSEQSYEVAKAIKEQFCYVCPDIHKEFVKYDTEVEKWFNKVYNGENSITKKPFAVDVGYERFMGPEIFFHPEFVNPDHKMSISDVVDQAIQQCPIDVRRDLYENIVLSGGSTMFKDFPRRLQRDIKRLSEQRLAQSEHLSGGKLKPKKIDVNVISHKMQRYAVWFGGSMLSSTAEFYQVAHTKAEYMEKGASCVRYNAIFGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAR0</accession>
    <name>A0A914HAR0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAD/DEAH box helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAR0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15632.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15632.t1"/>
        <property type="gene ID" value="Gr19_v10_g15632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="6">
        <location>
            <begin position="163"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15632.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26054" checksum="4E2489720516018C" modified="2023-02-22" version="1">MDALLDDIDGGEQENSENESASSQQQSSNTMERLEHEKQTQARAFSENLLAKLGGGGSADQLARSRKRSATDANGVQQQDEASPPAKVAVRDSESNIKDEVDGELGDDVENRFIVNCKRIRSIQYAAETNCNHEVVYPFDVEHMPLKKSSNPAKFYEFKLDMFQKQAIKCLDNSQSVLVSAHTSAGKTVAALYAIAMALRDKQRVIYTSPIKALSNQKYHSLYARQRTPTLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBB5</accession>
    <name>A0A914HBB5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15499.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15499.t2"/>
        <property type="gene ID" value="Gr19_v10_g15499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15499.t2"/>
        </source>
    </evidence>
    <sequence length="309" mass="35530" checksum="53E465F42D10FF23" modified="2023-02-22" version="1">MGWELGDLQIRRAIGGNGAEIVKFVECKFERLLPIPQEPLPDKVIGFKWLTIRYIDQSVIGYLQCIRRLFDSKGTNLFIRSPGIQNRSWEIIWKEIWPLIKDNICGFYLLSSELGRLRQFSPTILGDCPKLRLINSVDVFPAFPADDSAGASSAQALAKWLHTPRGDGHPKVLKCSLWERVGGGERVGGERVVLLPLKLEFINSTYSVNFIVCLWNCSAGIVEPFELKNNLTGERLEFRRFNKDFCLLVRCPIERDKDKWAKWEKEAIEWKCHRQWNRIWIVLDDRRGSIGDGMLDANEGPSEAKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBM0</accession>
    <name>A0A914HBM0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBM0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15852.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15852.t1"/>
        <property type="gene ID" value="Gr19_v10_g15852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="317"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="319"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15852.t1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45285" checksum="560727D2D8DE0757" modified="2023-02-22" version="1">MPKPKQHKSEVGRSSGVEAVQHVVRLRHIPYGFFEKELSGYFSQFGDVKRVRVVRNKKGNHVGTAFVEFKDGAVAQIAAQTMDNYLLAENRLRCKLLGQDKVPKCIWRGKRFVKIARPGENRLIHAKRQSEDRTPEKEKRRRDRFVDELKKRMAKTANPPICAMNIARLLEIGTDHHQKSHRLLHAIPALSPPPESVLLTSSSSTTIASPSNGKENRQNQKATTAAAAAITLTNSLKFGIENILQPEFGTSTSLLGPTTADVQLHQNPFCSPPNCSPPFAQPTSCDSLPSWIFCTRYSDRPSSGQRTRKSKRRELTEEEKRPRTAFTSEQLERLKTQFLNSRYLTEKKRQELAHELGLNECQIKIWFQNKRAKLKKSVQRVQQTPPHGLIEPVLFKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC15</accession>
    <name>A0A914HC15_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC15"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15965.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15965.t1"/>
        <property type="gene ID" value="Gr19_v10_g15965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="746"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15965.t1"/>
        </source>
    </evidence>
    <sequence length="988" mass="114397" checksum="49FE4028573EBB69" modified="2023-02-22" version="1">MNEITAMTFDLPSPDKRIELFRLDAEPVMKYVTPGFGMFISRFTDDMLVSYFKNKEIDKYQKNVPSHLRYFYLIRAVWKKVILDEQRAEWEKRAEDEPHLSQLTENSPDLFDRILRREIDTKLYERSEAFAEFKARENAFKEFFMQKYNKNLEVPSDSPFERTVNLLINVDYSESITSPHSIQLLKVFLNLEQFVNVLIESDKEKAVELLKQTVNYNPQQKEYLLPMLNKLLPTSSCEDLDQIATMIRTSSQSVKTDLDKLDYRQLAFYPLLILEKLLCRFSPDRVGAQKAAEFRHQALKLGVMDFVLECISHFTHQRSNFKKTRSWRMPLPQYSVSFSMENHVKRPKEPSDQNQAEPSKSEYAYRDKIRFAKGTGYGSGDMRQLWDYKETAQKIRYDDDNIACLLNILRAFIMPPIHEQDSTLSERSSENKNTSKRGQNNRRKNSDQKRPSKSMDALANRNSIPMEEEFLKLLQRSSLRLVIRSYLMSDTLLEVHKNIASYHAVFQLLVALSKSLPIKTDVLSLFANFYDDNLGLEEIDTDDEGLSFGGRTKAEEKQEILPFDVIFCTEEGGGFKVERNALIELLKHFSTNIDNYLKRIGSTITNQPSQVQNGYFDLFSFFGFGSVRNESGEKEVAGREEEKQLQELSSICKNVTSIFHELNKSEIGSISGEILKKLRVRDPSSSECLDGTAGTSASTDNESEKYCNAMQGLKFAVITFEKIFKKEAYFYRQKIKKEQTSGAANTTSRRIAREIQSLQSNLMLTKSTSAFVRSCEEHLDAMKVLITGPEGTPYQNGCFEFDFFFPPNFPQSAPQVHLRTTGNNTVRFNPNLYNEGKVCLSILGTWPGRPEEQWNAERSSLLQVIISIQSLIFVNDPYFNEPGYERYNNTQQGDLASQRYNAVIQVATVRWAILEQLKRPPIELENVVQLHFWLKRDEISDQIKGWIEEWKERGKQDNRFSATAGELEKLLKQVNDEFQKLKKLNLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD23</accession>
    <name>A0A914HD23_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD23"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15920.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15920.t1"/>
        <property type="gene ID" value="Gr19_v10_g15920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15920.t1"/>
        </source>
    </evidence>
    <sequence length="489" mass="56416" checksum="AA9B79D453060EDF" modified="2023-02-22" version="1">MMKMKQGREGTEEMMKMKQGRDRTDEMMKMKQGREGTEEMIGMKQGREGTEEMIGMKQGRDRTGNGREGTEETMKMKQGRDRTDEMMKMKQGREGTEEMIGMKQGREGTEEMIGMKQGREGTEEMIGMKQGRDRTEEMIGMKQGREGTEEMIGMKQGRDRTGNGREGTEEMIGMKQGRDRTGNGREGTEETMKMKQGREGTEEMIGMKQGREGTEEMIGMKQGREGTEEMIGMKQGRDRTDEMMKMKQGREGTEEMIGMKQGREGTEEMIGMKQGRDRTDEMMKMKQGREGTEEMIGMKQGREGTEEMIGMKQGREGTEEMIGMKQGREGTEEMIGMKQGRDRTDEMMKMKQGREGTDEMMKMKQGREGTEEMIGMKQGREGTEEMIGMKQGRDRTDEMMKMKQGREGTEEMIGMKQGRDRTDEMMKMKQGREGTEEMIGMKQGRDRTGNGREWTEETIKMKQGRDEHLSFYHWPFFIRWFPLICAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE52</accession>
    <name>A0A914HE52_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE52"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16518.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16518.t1"/>
        <property type="gene ID" value="Gr19_v10_g16518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16518.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10876" checksum="6044B102543084EB" modified="2023-02-22" version="1">MRCLSMSPSMPSEREEHFWPLEAKMGKGKMAKNIICCPFKQFEPNLRLCMNHFEPYRIVSDNPADNVNGASDNCRRTTPSTAKKLHKMLSRSTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HES7</accession>
    <name>A0A914HES7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HES7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16694.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16694.t1"/>
        <property type="gene ID" value="Gr19_v10_g16694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12632">
        <property type="entry name" value="RRM1_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000010">
        <property type="entry name" value="CUGBP Elav-like family member 4 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000198">
        <property type="entry name" value="CUGBP Elav-like family member 6 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034648">
        <property type="entry name" value="CELF3/4/5/6_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="81"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="174"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="559"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16694.t1"/>
        </source>
    </evidence>
    <sequence length="676" mass="70598" checksum="4D22FA9E79305639" modified="2023-02-22" version="1">MLLLLPPVSECGAVSRSSISQMQSTTEIGPRLMMSSSSIMANAENGIGTARSAQQQQQQQQQQRCSSTDSNGFPVKDADAIKLFVGQIPRNLEEKDLRHVFEAYGKIYEFSILKDKYTGMHKGCAFLTYCHRESAHNCQLSLHDRKTLPGMNRAMQVKPADTESRSGSPKQEDRKLFVGMLSKQYGEEDVRAMFQPFGHIEEITVLRAADGVSKGCAFVKFSQAPEAQRAIIALNGSQTMRGASGSLTVKLADTEKERQMRRMQQMAAQIGMLNPLLANQLASATSSALGTAPSPATMAAMSGTAAAAAAAMATPFGTGAPTATSSLTTAGQFGLLQAQQQAQLVASMAAHQAAAFTTNPAMALGGTAGAYLPMAALHQPFVSAASAGLLAAAAGVPAQSAAGLFNAAALPTASSLQLLQQHAAAVAAQQQQQLSNQNFVSASVAQPQNSVTVSNTASAADAVAANSAAVAAAMSGTAAGGAGGGGYPSGAPVGIMSGTANGTTAANPYGQLLGFDAATAATIVAQQHAAAAAAAVAAQQQQQQHQQISSAAMYSCYALQQAALMVQQQQQAVQQQQQQQQQPQLMAAANLAQQQQQQHQQLQRDDYSLLGPDGCNLFIYHLPAEFDDAKLAQMFIPFGQVLSAKVFVDRATNQSKCFEPIKVGRRQPIAIESGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF80</accession>
    <name>A0A914HF80_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HF80"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16067.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16067.t1"/>
        <property type="gene ID" value="Gr19_v10_g16067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16067.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11332" checksum="2C7C6720F2CC684E" modified="2023-02-22" version="1">MLHYFGFVLEGFQGQPNTISSTNPSSTTERAATTEYVPWLYRFGQKLMPCLDNIPSDECERHDDDCEDALHKREMALFCCGTCRAKHPNFLPKQSVQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFB9</accession>
    <name>A0A914HFB9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="function">
        <text evidence="13">In parasitic nematodes PEPCK carboxylates phosphoenolpyruvate to oxaloacetate thus introducing the products of glycolysis to mitochondrial metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HFB9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16624.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16624.t1"/>
        <property type="gene ID" value="Gr19_v10_g16624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF16">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="16">
        <location>
            <begin position="68"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="15">
        <location>
            <begin position="299"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16624.t1"/>
        </source>
    </evidence>
    <sequence length="665" mass="74188" checksum="BE3D516806E35B47" modified="2023-02-22" version="1">MATAVTDTAPMDPAKLTPFKETSAVSASLRQISADAFYVVNEVVIKRLGPIPILKGDFHLLPFKVQRFVAEKAELCRPRGIFICDGSEHEAEEMTDLLVERGVLTPLGAYENNYLCRTDPRDCARVESKTWMVTRAKYDTVTHTPEGVEPIMGHWMPPTQFADELDARFPGCMAGRVMYVIPFSMGPLGSPLSKIGIQLTDSTYVVLSMRIMTRILPDVAEAIGDRDFVRGIHSVGLPRPVKQKVFNHWPCNPERVIIAHRPPEREIWSFGSGYGGNSLLGKKCFALRIASNIARDEGWLAEHMLIMGVTSPKGKEHFIAAAFPSACGKTNLAMLAPTLPGWKVRCVGDDIAWMKFDEADGRLYAINPEAGFFGVAPGTSKKTNPMAVSTFQKNSIFTNVAETSEGKVYWEGLEDELRGREGNVKVTDWMGNAWKLGDATPAAHPNSRFCAPAKQCPIIHPDWESPKGVPIDAIIFGGRRPQGVPLVFETRSWEHGIFTGACLKSETTAAAEHKGKSVVHDPMAMRPFMGYNFGKYLEHWCSLKQSGRKMPRIFHVNWFRKSADGKFLWPGYCENIRVIDWIVRRLEDKPDIGIETAIGTIPTRGSMNLDELGKIDWDELMSLPPDYWHEDAKEVRTFLEEQVGTDLPEAILNELNAQEKRIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG90</accession>
    <name>A0A914HG90_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG90"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16341.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16341.t2"/>
        <property type="gene ID" value="Gr19_v10_g16341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16341.t2"/>
        </source>
    </evidence>
    <sequence length="224" mass="25856" checksum="CBA426A244783A8A" modified="2023-02-22" version="1">MRKIFKEIQYFKRFFPKFLKKNAIKTTKFNDEFEGFPAKFTGFVIIGSYTNRRHCGSTPAAEKNPLSICLIKSCRLIQIFAICHRKFVISSTRGVELQTNTFQQLSEGKRYRYIIYKIVDKEVIVEVAVSSDDIGSAGDESYDDNSKAAYESFVKDLKERTEDAASRCRHIQDGQNCLHPALPGWCFNQEENALRIILQFQVSDESEIAHKELLGKLNDKYRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGA8</accession>
    <name>A0A914HGA8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGA8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17236.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17236.t1"/>
        <property type="gene ID" value="Gr19_v10_g17236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021640">
        <property type="entry name" value="Mediator_Med28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11594">
        <property type="entry name" value="Med28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17236.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18271" checksum="F485340069C39D26" modified="2023-02-22" version="1">MMSDRASTSTRTSRDGGEPCAEKLREIGALISAFPKGNSNDGQKPPDSALGTALKNMVIQWNSLLSQVVTEVDHPQPILEHIKETAEFSVKQFRDACLAMNSELTRISMDWQLNFPEEMVKQEIAEYENSIRRQEDLLTKISQKLDEEISSGENSNFGTNFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGY5</accession>
    <name>A0A914HGY5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGY5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17266.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17266.t1"/>
        <property type="gene ID" value="Gr19_v10_g17266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000353">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF5">
        <property type="entry name" value="WIDERBORST, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17266.t1"/>
        </source>
    </evidence>
    <sequence length="559" mass="64117" checksum="E325020E713C18EC" modified="2023-02-22" version="1">MLSFPSIPCSLRRFLEKKLSRKLKCSFVSRICLPFLLEVKESRPATRFHHQKRPERRRARGSSRRRRRLIGSSRYHADNEPDLAQLPLIKDAAQADQTYLAIQKLQQCQKIFDFYDPVSQLKSKEIKRAALNELIDYITATKGAVCEPLYPEIIRMVSKNIFRVLPPSDNSEFDPEEDEPTLEVSWPHLQLVYELFLRFLESTDFQATIGKKYIDQRFVLQLLELFDSEDPRERDFLKTILHRIYGKFLGLRAFIRKQINYMFLSFVFETESFNGVGELLEILGSIINGFALPLKQEHKVFLVKVLLPLHKPRCLNLYHAQLAYCVVQFIEKDSSLTPQVFDSLLKFWPKTYSSKEVMFLGEVEEILDIIEPEQFKKIIDPLFRQLSNCVSSPHFQVAERALYFWNNEYILSLIEDCSAQTIVALVYNVLKTFMEMNGRLFDELTTNYKLERQKEKKREKDREELWKRMDSLDIGGLILQIEQGGALPEPTILAKTPLTQFIEKPSSGTGAVTAADGGTQPSKDRPSCGAADTNPSGATTSAIHATANSPPAAALHGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH00</accession>
    <name>A0A914HH00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17278.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17278.t2"/>
        <property type="gene ID" value="Gr19_v10_g17278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17278.t2"/>
        </source>
    </evidence>
    <sequence length="393" mass="43852" checksum="9132D5051974F170" modified="2023-02-22" version="1">MSTFSTYQPQLSMFGDVPMFATANSSIVGTSNATASTTASESTSVLQLHGRQQPSAALLQQQLRMRKEIYRYTCDELLFAAAWSNKLYPDKRFRLVVGTLLDEEGTRSNKVYIIELDESAGELVRKASIVHGYPCSATQFIPNTDVSQPELFATTSTCLRIFRYHPAIASISQECELSSTKSSAYSSPLTNLDWNEVDSTLVATCSIDTTCTVWNIETSQPVGQAPTVKGMQKTQLIAHEKPVHDIAFTRLDNGRDQFATAGADGSIRLFDSERRMLNHLAWNKRDPTKLATVAHDSNEVVILDVRIPCRPMARFGNHRGAINGITWAPHSTVHLCTAGSDRQALIWQMNHFNREEPILAYTAESEICQIHWSSNFHQWISICFGNSLEILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH32</accession>
    <name>A0A914HH32_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HH32"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17109.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17109.t1"/>
        <property type="gene ID" value="Gr19_v10_g17109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="81"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="81"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17109.t1"/>
        </source>
    </evidence>
    <sequence length="533" mass="59739" checksum="15D9BCD3CE6A3945" modified="2023-02-22" version="1">MSVDQIKEEFYQWDAEKDSSSSNLQSAQTPLAEFDNELALGDHLPDNSTTIKDVVPQANRGGGGGKQKGGRWERQKWLQNRVPYTYTELIAMAINSQSDQRATLAEIYEFLRVNFDCFRGAYTGWKNCIRHTLTLAKSFHKVPRAERAGRVGLGNYWALSDYFHRRSLAGGLGRRSQKTGVRKAFHNIEEQKKQNLHSNDVEKALAANVKSVDEHKHNATSNHWEQQQSNDVEELLRRIGIPPKAAPCGKEQQMDGDKGNAQHRLRQQPSLSPAAVQFEAAQTRTNRIGAGTKLDLLLTKMGHLRNAKCHATASTLRAASTSSSSYFPSNAPLHNVHDKQQLLPSRHASIADLDHLLAHPPFTSTISSLASALIQKADSSPSNVQQLQKQPATNGMDEEEVITVDEDESVGVEQQQQQQQQQLQRQDFGGGQDGPSVAFVAQVSAWLGLVAGELRLRLQCDGKNGSMVLSSNHQARGAIHRLQFVPVDDRELVIRQFVGDKLYQEKRWTWHECQEEQTLHAIRGICFHFFFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHX7</accession>
    <name>A0A914HHX7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Achaete scute target 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHX7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17526.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17526.t1"/>
        <property type="gene ID" value="Gr19_v10_g17526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF18150">
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    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="54"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="12">
        <location>
            <begin position="459"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17526.t1"/>
        </source>
    </evidence>
    <sequence length="565" mass="64429" checksum="FA3FAB419D1E6EDC" modified="2023-02-22" version="1">MFSWLGNNTGKKDQDVLESVSEGLKKIYKQKLYPLEDFYRFHEFHSPALDDPDFNARPMILLVGQYSTGKTTFIRYLLEQNFPGIRIGPEPTTDRFIVVMHGEEEGVIPGNALVVDSTKQFRALTKFGNAFLNRFQCSMLKNEVLSGVTIIDTPGILSGEKQRIDRGYDFSGVLEWFAERVDRIILLFDAHKLDISDEFKRCIEALAGNEDKIRIVLNKSDMVDHQQLMRVYGALMWSLGKVFKTPEVARVYIGTFWDHPLHYDINRRLFQDEQHDLFVDLQSLPRNAVLRKLNDLIKRARLAKVHAFIIAELRKQMPSMIGKEKKKKELIQKLDKVFEQLQKEHSISPGDFPDVNKMRANLENADFAKFNAIKPRLLEVVDNMLATDIARLMEQIPKEEAAIVMNGEQNGGLAGRLDQSVVRGGAFDTQTEVATPFGFGKGEGFDKGSDESEWVVSRERYKYDEQFHLLQPVDGKISGRIAKEHMLKSKLPNSVLGKIWKLADVDKDGHLDEDEFALSNYLINLKLEGHELPMELPKHLIPPSKKAMTGGDSSSDNQIYPSLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI81</accession>
    <name>A0A914HI81_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI81"/>
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        <property type="protein sequence ID" value="Gr19_v10_g16865.t1"/>
        <property type="gene ID" value="Gr19_v10_g16865"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16865.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12555" checksum="B876DABF16B7BAF9" modified="2023-02-22" version="1">MLCRLQGIVVKMEKYQKGQQLRIVGLQKTVATLRGPQNRWDLTKSHRGLTISGLIVVAENANWGPCSVFAALPIPTKKDFGIFYFEVTIQEQTLPVCLSILPPNCPICSRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI85</accession>
    <name>A0A914HI85_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI85"/>
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        <property type="protein sequence ID" value="Gr19_v10_g16868.t2"/>
        <property type="gene ID" value="Gr19_v10_g16868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16868.t2"/>
        </source>
    </evidence>
    <sequence length="288" mass="31609" checksum="F546F0F1B4B4088D" modified="2023-02-22" version="1">MAAHPNNVEAAIEHKRVSFGGEEHVQMIVYDDGLTDDYSINNHNNKHNSRHSTAFTEPDAPPSRVKVTTETAQLPRPISPPAQIGPSSTMSGQHHHHYATTAAESAIAGASGMPSTGTMTSSSTTVVTSPPLPSFVKRAEHDNENPFRPDEPLYHEVDTIVEAYRQRPFPPSPTHGSPVPPHQQQQQQQHVPSSSSSTWCTPTKRSSIHNQQQHQQHQQQQYANGGGGSGGGRNNSLAQARRDRENAMLMDQQQQQQTPTADGIGPPHKAEVIHLKEEKKKRACCHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ31</accession>
    <name>A0A914HJ31_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HJ31"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17352.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17352.t1"/>
        <property type="gene ID" value="Gr19_v10_g17352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17352.t1"/>
        </source>
    </evidence>
    <sequence length="458" mass="51254" checksum="64037B0324BEF2B5" modified="2023-02-22" version="1">MDNGTNVQTVKRECIEVAEAIRAQGINDLASWPSFQSGFTIVYGCLFLLGLLGNGSVLLAFAQNKRLRSARNLFLLNLILTDILLCLTAVPVTPWYALTKDWSFGSLMCRVVPLSNSCAVFVTSWSLTAIAVDKFMHIIDLTREQFSLRTAGFVTFIIWTLSSLLNIPYLLSYELVNGDYYVPKNSTPFCGQFCDELNWSGDTQRRLYGTGVMLFQFVVPTGIITYCYWRILRKVHKDMIVQNVQFSKSLSNSQRTDALNRKKRVNYILIGMVIAFIGCNTPITAVNLVKDFKQEPSWLKKQPYLWPLVAHVIAMSTIVFNPFLFFWLTAKDKGQKGNLTGIATTTSEIITSLMSRMHSLRSTGGNEEARLKRMNKRALQLQRCESAGSRRTANGTSIRLGQLSSALPLSQPLLLRENGHTATVHSRTDSSRNSPSGMAEGRRSPLAKAYSLRANSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJR7</accession>
    <name>A0A914HJR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJR7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2123.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2123.t1"/>
        <property type="gene ID" value="Gr19_v10_g2123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2123.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34744" checksum="EDF3A65A1F6AE939" modified="2023-02-22" version="1">MNSNTESMNFMIDYDKQIDTNCANKKSEAPNAPAQFLYAPGRGRYTVIRWTLSCKFASLDELDSFRRGRGMYWQKIVGRIYLFCSTKKCPYKMLGIKNECHEWTVYERNEHNHSADDLFPIRRHTKRRQTQKNCSSSTNNSIESSSIEENLEQRPRLLLKFRKSSDGFLLDRSTTSSTDFLDDVAIQKDEKLQAKLFESAECERELEKIGKKWHLILKEKKGSFLFVPPRDSKPFKEGILMAFTDRGNHIRMDEFKALHLQPDKIRRWPKALGHATIMQLVNEQCARLFACTDHDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJX0</accession>
    <name>A0A914HJX0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJX0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g20.t1">
        <property type="protein sequence ID" value="Gr19_v10_g20.t1"/>
        <property type="gene ID" value="Gr19_v10_g20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF12">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g20.t1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47474" checksum="AA707B873FA9AE33" modified="2023-02-22" version="1">MSSVPSNNTVEIPLSSADLMIRQMMPANNDRYNVQRPSARLIPNGLNGFLPPKSLLMAQMSPLQNLAQLQILDLLAKAQMLAQSQQAAALHNAKAAQQSVPEMNKLLSSPSDRSSPNCADQNGDNSSRRRRRAVANLDNTLDGLVAKRAEQMPMKRRYQSETEAIELPDDELETKRMEADPDVCTRMCSVCGYQGKWVSEMIRHKRVHTSDRPFKCKYCNRTSKWKADLIRHVAKTHGIRVVSKYSRSKAMDLGMQQQQQQQQQQKLLTVEDSADFDAFSSSSCESSAKDENNNNNNGKNGAAVDSLNSQERKAQRLLSSMARNKQLVQRQRLQQQQQKQQQQQQQKQEAKAETEQQQLVLNPLRVGNNDAVVGVGTTELGLPTLQRSSDASLALLQLLNILPHLAPQAREDGSTSSLFSGQVASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLP7</accession>
    <name>A0A914HLP7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2501.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2501.t1"/>
        <property type="gene ID" value="Gr19_v10_g2501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2501.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8942" checksum="1AEF912EB398E8E5" modified="2023-02-22" version="1">MKLRLENVSVKQCSLFSDEFPSFKQSNTGGSGGAGHWYALKRQLAADRQAAEAIVREIKFLIEAKSTRTPVVFTLIQIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLR7</accession>
    <name>A0A914HLR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLR7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2517.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2517.t1"/>
        <property type="gene ID" value="Gr19_v10_g2517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2517.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30016" checksum="9DCE6BD4D929625F" modified="2023-02-22" version="1">MGQRTVRHKCRAREARESVEKTTTDGPNPGTECESVDRNSVSAENEKILGQDTEEAQQRRDRQNHVNRRRTDGPSLHSLLCSSASSHPPPMVSQPPSHKAPGVGTETFFGWAQTGTIHPSSVNVCFLLLLGSCRHGENGKRKNDNNNDKSNSKNNVRKQKIKAPRHPAGDLAPGTSFDGMRRGGRGEGIKAKMHLIVLRLLLHLLHSAVVCVVVVVAAGDGLEPLSSRSSGTGSGGRGDQHIQSSVEEGRPGAWGPSAPSREEEQQEDDLIVLLPPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM86</accession>
    <name>A0A914HM86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2441.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2441.t1"/>
        <property type="gene ID" value="Gr19_v10_g2441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2441.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8441" checksum="DCEB8769F37AD6D5" modified="2023-02-22" version="1">MSGRLILRTIKAEWADQQPHQPQMGWRNQSNSAEIPRPSTTSVGFMEDLARSLVEMSVRSNTGRSAPDEGSDQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN24</accession>
    <name>A0A914HN24_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="4">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2292.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2292.t1"/>
        <property type="gene ID" value="Gr19_v10_g2292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="55"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2292.t1"/>
        </source>
    </evidence>
    <sequence length="1896" mass="213917" checksum="BCADB609C5DAD0F4" modified="2023-02-22" version="1">MEVVEAIKEVEPNLKLDDAQSTTNNVNKMIDFNTVQINFATIRNPNCQIRRWAGIGLYADDSTSSGPRFIETCWNSPDEWLNDGFIAVYLAYLASISQRKVVVVDSLVSTPNTAVVRRSSFKNYTFGYDPNNAAEVILMPLNFPNHWTLLVYDVAFGTFFADSLHISRMDFARSELIKDIIVDIVPVERCSIVIENISNLTPQQDGFSCGYFVSDNVPYHPRADVALPCPFVKRLEMEDGQSSSKGVQSNVQEDSDDSDDIMIVDVPANEKKVEESMFFIDPPLHEQAEHPASAAINAVLAEAQLPGENQADELALIVESCQAQEPIAQAAEVVFKRPRTPPRRSSRIKRLSNSLSRSPSPAAKRAPTTKGLGLATPLTKRCHMVHKSWHCAAAAAKHFPDYSDSGKLGEKKCPHCGAHLFQHEDSNICCRQGRVELPTLNPHPDELKQLIVGDNQTREGKEFVRNMSRYNNLLQFASVSAGNKPCPAGGPMAVILNGEFHRRISSMQAGSTQTPGFGQLYILDPVEAMEQRRNNPTFTGEKITTNEEFVQGHKLNEKTLESLEKMIQENHPAAKAYKQAREQLQDLFKTQKAEELRFFRMTLLDQRRAPAAVKDPKLHPHQIITPSTGEGMFAIHADPSGAPPPKGIWVENKHGQLNEIAPFSPWTDSLAYPLIKPLGDDGYYTGIKYAKPPSRKRKSDVSTDHLFDTDVDSDLESCAADSDALSDAGSVASGTSSVSGRFGKARQFVSLRDYCKYYLAIRDGDVAAGYHHILACGGGLGQRWILDQAAKIDWQIATFLRRPDMDLRISTPRNLLQYLINQYNKQKARQNPNAQRKSVDDIGSVVRLSEKNVNSLQYWKKMYEDCNTIFARYHDAKKARLFITFTNNRDWPEFKQNLYKNGQVFTDRFDLWMRVWCSKIAVFRHELYEKNYFGTIIGSGESMEFQGRGGPHAHIVAQTDLNAIPEVIQEYIWAHIPSLPDKDDNTPIAQMHREIRELIHMQLHRCSDTWCGPKDPKTGRCKKGFPATYSKCTILHPDRPAVYFRPSPAEGGAQIEVNKLIYDNSHVVPFNPFILLRFRVHHNVLFAYGNKANIKYALKYPFKEPGHCCVACKEESGSKIGIDEPAQYAKMNFRGATEAYAVVNSIAFVRLSHQVVKLSIHLPNQQPIVFRAGQLVSKAQQIEQGELPETRCSAYWKQWQNEWKNEPEFKGMLFVQVPERFRWVKDKWVAYKRKQTKRPPIGRIVPVPPSDPERFALYQLMRHYPGDPAQLKMVNQQPCTSFIEAAIKHGLLEDDRVWNKTLEEASLSRWPDQMRWLFVSILVFGQPSNARELWDKYKAQMYHPHGIASKAQRLAKELQALADIDWRLFNFGFSCVHFGLPDPPNSMAKNTEKAVEEFFFGDDDLNVPPGLPNANQPEENQPPPLNSDQQMVFDAVVQATQTDPSDQSVPRRLFVYGDGGTGKTYLFGQIIRRLRKAPYSKKVLATASTGCAAILLPYGKTAHSTFRLGREVSLDKLPSIPLESFFARRIREAQLIIIDEITMLNNTVIEVIDRVCKEMAIRQHKELLFGGKTVIFSGDFKQSLPVVPHEGLAAQVAACFQTSPLFGQFTTMKLTINHRLGKGQQDYAKMCRQIGHGEAGEFFWIPPQFLLHSSEDLINFVYPDFQQLLGNDQELLNRLILAPHIQTCDEINELMMDNVPGQVREYLSTDKPLDERPLDIDEIESEVAALNQRADSGMPPHRLRLKVGCVVVLLINKSDREGLINGTRIVIEELGENKITGRAINGTAVGGQVRFFIERTRNVYEDKAPGGLKYERLQFPIKPAFAMTILKGQGQTIRTVGIDLEREVFSHGQLYTAFSRASDGNNVRVYAPNRETDAQGRAKVLNIVATNMLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNI6</accession>
    <name>A0A914HNI6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNI6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2936.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2936.t1"/>
        <property type="gene ID" value="Gr19_v10_g2936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037800755" evidence="2">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2936.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23113" checksum="995BCB9765438CA9" modified="2023-02-22" version="1">MNKWTAATQIVVWLLLLVVVGEAFRFPSVRLPFLRPRPRPPAAGVRPRLVEPQPFQARPRGAPAIPLPPANARPVKRIPSAPVAVHLHLAPVLVVPHYQQVTAKAAPEKHSTEVAKEAPEKCSTETAKAAPEKSSTEEAKAAPEKFSTEAAKAAPEKYSTETAKAAPEKSSTEEAKAAPEQPKTEMAGAVTEETKTEMAGAVTDVTKTEANEPSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNL0</accession>
    <name>A0A914HNL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3176.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3176.t1"/>
        <property type="gene ID" value="Gr19_v10_g3176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF10">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3176.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11852" checksum="BCAB878024C17BCF" modified="2023-02-22" version="1">MGKDYYKILGIANAASAADIKKAYRKMALKYHPDKNSEPGAENRFKAYDVLSDPKKREAYDIYGSAGPQSNGPCGAGFGCHYTFQGDPMQMFAQAFREFNGGAAGGGPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPX6</accession>
    <name>A0A914HPX6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridoxal kinase</fullName>
            <ecNumber evidence="5">2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pyridoxine kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxal + ATP = pyridoxal 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57761"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25105"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25108"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16709"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:25109"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914HPX6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2806.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2806.t1"/>
        <property type="gene ID" value="Gr19_v10_g2806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="15">
        <location>
            <begin position="122"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2806.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38757" checksum="B81CBA3828268293" modified="2023-02-22" version="1">MDGSNDSNNCVGRFPSPPLTPLEKYLAKERDDKRVLSIQSHVVSGFVGNKCAVFPLQLHGFEVDSINSVQFSNHTLYPNVRGQLLDERDLANLFEGIRLADLTSKYSHILTGYCGDASFLRQIAAIIRECRRHRPGLVYVCDPVMGDNGKYYNAMSRELCAIYRDEILPLADVITPNAFELSELSGFTIANEADCLRAIANFHRVQKVRIVVMTSGLPDESKASSRSTMYCYASETLPLTSSIAADDVQLRQFRFEIPLIAGTFVGTGDLFAALLLAWLEESDGDLCRAVKATIASMQSVIGRTSDFAFAHSTHPTVQQRELRLMQSRLDLLRPKENKINYIELHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRL6</accession>
    <name>A0A914HRL6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRL6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3297.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3297.t1"/>
        <property type="gene ID" value="Gr19_v10_g3297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036974428" evidence="2">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3297.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24516" checksum="9D5EFD72EB4D6B09" modified="2023-02-22" version="1">MEEFWILILVALFASNLLDKAESVKLELKTFDEIFGEGWWDKGEAEDLKTPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQLGQIEPNPTDQNPLLTESDHSENAKNGERPNEIIKEITSNEKRKIVDRFHAMKDKKAELMRAGFKNSYSNQIDETVAKELGLNFRTIYRWKSELRQPSDFGAHKPFVGVFQYFLQERISVGQICGGEEHGKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS45</accession>
    <name>A0A914HS45_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 3</fullName>
            <ecNumber evidence="19">2.3.1.311</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">tRNA uridine(34) acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Component of the elongator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.311" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A914HS45"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g415.t1">
        <property type="protein sequence ID" value="Gr19_v10_g415.t1"/>
        <property type="gene ID" value="Gr19_v10_g415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="24">
        <location>
            <begin position="88"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="23">
        <location>
            <begin position="402"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="684"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00063757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g415.t1"/>
        </source>
    </evidence>
    <sequence length="794" mass="90677" checksum="BF0F6526DCA4C1D2" modified="2023-02-22" version="1">MAPNQRDGDCVNGKLNAKELFTRCVNEIIAKLIVAQREGRDVNLNRLKCEISSKYGIKTQPKLVDIIGAVPPQFKEVLLPKLKAKPVRTASGIVIVAVMCKPHRCPHINFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYNPYLQAVGRISQLKQLGHSIDKVEFIVMGGTFMSLPDDYRDYFIRNLHDALSGHRSCNVREAVAYGEHSRIKCIGITIETRPDYCVPRHLDDMLSYGCTRLEIGVQSTYEDVARDTNRGHTVKAVCECFHMSKDTGYKVVIHMMPNLPNVDIERDIEQFIELFENPEFRPDGLKIYPTLVIRGTGLYELWSTNKYQSYPPQVLVDLVAQILSLVPPWTRVYRVQRDIPMPLVTSGVEYGNLREHAMARMKQLGVKCRDVRTREVGIQEIHEKVRPYQVELVRRDYTANGGWETFLSYEDIDQDILIGMLRLRKCSNKVHRAELKGAVSIVRELHVYGTAVPVASRDPTKFQHQGFGQLLMEEAERIALQEHLSTKISVISGVGTRHYYRKLGYELDGPYMSKMLIDRSPPIDCFKMSRRGGFGGATAATGVRAIANVLGISRQEVSQYTHEQIKNEPLPLYPPLAKDPLPLEDSKELAFMTDAKLEFLHRFRESPFYQRRTGKRDVRRYTDKYRLMDKEPFEPHWTRLPSEINWRAKSGTSGRRPSAKRARMDENQLLERLGQREAKGLDKDKEGDEEGAHGKAEDDDDEENATTRPRPLNEDEEEANYSDEDYLMEGANDYVDTYFDDGEGNDDETNALEEEGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT59</accession>
    <name>A0A914HT59_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CCR4-NOT transcription complex subunit 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HT59"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4233.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4233.t1"/>
        <property type="gene ID" value="Gr19_v10_g4233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="521"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="380"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4233.t1"/>
        </source>
    </evidence>
    <sequence length="652" mass="75421" checksum="E7A20C83D9FD9AA8" modified="2023-02-22" version="1">MAEKRKLLNEIDKCYKKIEEGFEIFDDIMAKMAEANSDNQREKFQDDLKKEIKKLQRLRDQIKGWQNSSEIKDKDSLSKFRKLIEQRMEIFKDVERENKTKPHSKQGLSAEDKLDPREKEKCETIEWLNGQIRRIQDEIDRTESKLETLSSMADTNRKRGKKDDGKKNEKEKVEELRKHLERVKFHLLNLEVCMRMINNEKLEIKDVNGKLKEPLEMYIDALDPENDDDPESLDPEDIYEELNFGTYLSQLGGITAASVDEEKGLNDNGCSISPQISLKDKQLNVSSPTVAATTPETDVFLFNGTATAPSTPVTTITTNLAEKVPFSAVPSSSNSNKPKHNTTSKSFAWVTAAADLQAPPRGRPRTPNDLDELQRVELDAAEVPGAAADDVASVTGSRKAPSIASPPRTPCTSKSPKSPRKVKMDEPPPMEEEDVEIASKDEEEEQRQESFEERMREREEEEEGRWKRLNHMIEQQLESQQPKSREPQETIIPPWLGASPLGMIALNDDLNNHLQMLDATLTRCPVQMDSEKTRSYLPKMPCQTPPYYPQTPLPNADSLEYYLRLSVEALFFTFYYMEGSRAQLLAAKALKKLSWRFHTKYLMWFQRHEEPKQITDDFEQGTYVYFDFEKWVQRKKEQFTFEYKYLEDKDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTW1</accession>
    <name>A0A914HTW1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTW1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4627.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4627.t1"/>
        <property type="gene ID" value="Gr19_v10_g4627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4627.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30473" checksum="181D3D774AE20485" modified="2023-02-22" version="1">MASFQKLNTNFLNKKLATAVSWKPMRLHDAVKELDEREECKNEEAYCMCDAYMFDNVLRSSGMCGNGTCNCCETDPSIAALAALKHIVYQPHPGCDDDGICTLSEGKPASKCCNEHYELNSKLIYGQLKINRENVNECGPNGHMTYYSRDFAVTREHATRGCANKTVWGLFAQKMNPSSTPIYGQLKINREDKGCGPNEHRIYYSPDFSVAPSRERAAKACADKTVWGLFAQKMAPPSSTPSKANGVAMPPSATYAIVVALLLGRFVLFLPMICGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUR6</accession>
    <name>A0A914HUR6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUR6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3956.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3956.t1"/>
        <property type="gene ID" value="Gr19_v10_g3956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038012437" evidence="2">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3956.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28579" checksum="CD2AF57BBE7A1E8B" modified="2023-02-22" version="1">MEEFWLIILVLLFATNSLDEAESVKVKLEELPLKTFDEIFGEGWWDKSEAEDLKRPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDHSGQIKRNSKNPPLTESDHSGQIKPNSTDQNPPLTESDHSDNAKNEQNENIAEDERKHENVAKELGISLKTIYNWKSELGQTKPNKYPHSEQTELMKRYYEIKDQNLKIRDEEIAKNLKIARATLYRWKKQFKRQQLHPNSVDGHSVEENAAANVQEIENSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUW5</accession>
    <name>A0A914HUW5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUW5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4704.t4">
        <property type="protein sequence ID" value="Gr19_v10_g4704.t4"/>
        <property type="gene ID" value="Gr19_v10_g4704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052664">
        <property type="entry name" value="BTB-MATH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743:SF165">
        <property type="entry name" value="BTB AND MATH DOMAIN CONTAINING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743">
        <property type="entry name" value="MEPRIN/TRAF-LIKE MATH FAMILY-C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4704.t4"/>
        </source>
    </evidence>
    <sequence length="323" mass="36993" checksum="5B59B7CFFE4C9D45" modified="2023-02-22" version="1">MEPSKRQSSTNIGGDQQTKDNKYKRSSQIVFRMPNFKEFSEGSGPKYVFSAPVVYINGLPWRILIKHLDAHVGIFLHCFGDKTGMAWSCRAAFQCSVVSCKKSGESLMKKGNLDKFDIYYANSCSWGCPDFIKFEELMDPKNGLYYDEKGDAVTFKAEVVVEEPNGMPGVRPEEALLVNGELVYVNKHRMRCQKFKLTKFRMPLPRLIATMDLLNMNAFENLLFLANRFLLCPVEKRCVDFLVTKSKKSAICKFRMAHQCGIIGMKNKILKDMTKEDFSKSGVYIDNFMESKNWMMEKLRNCENGTKNCLARNEGGRISIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV03</accession>
    <name>A0A914HV03_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HV03"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4420.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4420.t1"/>
        <property type="gene ID" value="Gr19_v10_g4420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4420.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36142" checksum="18CD700957147EC4" modified="2023-02-22" version="1">MDFDPFEALRLEPCTDKAKIKKKYRQLAKKFHPDKTGSDDSEFKRINKAYKSLLEMDDANTLAEYVVGTFYVLAQCVGGKSFFGGPAKVGLIAAQNGHIKVARRLLKRGADPRRTGTVMVDGQMINKVTPLRIAAFKGHLKMCKLLVAHGTANDIDQDTKRMLICATCYGGGHLGIVKHFGTGINYCERLALTAASFHGRGDIVRHLLSEGKASAGQSSDKSNSSSSSSSSWSWREFFDFLAESFREMPNFAELIKECIQIWSHIGGVLSAIFSFIFGPAWVFIGAVLIFAVGSLFIYDLKTIVSTYILLAFIAVFVKFGFDDIDDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV47</accession>
    <name>A0A914HV47_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HV47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4447.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4447.t1"/>
        <property type="gene ID" value="Gr19_v10_g4447"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g4454.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4454.t1"/>
        <property type="gene ID" value="Gr19_v10_g4454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
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    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4447.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4454.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15157" checksum="868F94AB349ABD4B" modified="2023-02-22" version="1">MPRHRAKPRSFHAGLKFPVGRVHRKMKKGPYAKRLANGVPVYMTSVLEHITGELLKKVGDVTQEEGKKRLTPRHLQLAVRRDEELSKLFERVSLAQVCVLPTIDSDDDASESEDASAAEDSTDDDGSSTDGGGDDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXQ8</accession>
    <name>A0A914HXQ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXQ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5630.t3">
        <property type="protein sequence ID" value="Gr19_v10_g5630.t3"/>
        <property type="gene ID" value="Gr19_v10_g5630"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="72"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="300"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="1042"/>
        </location>
    </feature>
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        <location>
            <begin position="1043"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5630.t3"/>
        </source>
    </evidence>
    <sequence length="1173" mass="124577" checksum="8B52ADDB2CA4C60C" modified="2023-02-22" version="1">MELLLSEDLWTNKTKVRPTARMKKYNHHTFVLSFILLAYFHKIGVETTAAPKVSISSAENECPSKNRSSVLQTVVLFDVSPENQVDFQQQKDRLIKTLRNIDRFSFGRQRFYELIIFHRTPIDKLQSTNIEEITGQIEGLSMTTIHETSPAKALNEGRSVVEKMPQAQSVILLVHDGHNTDMASETLSASARLSKLKVSIFAIAGGKTPPALAKLSDYTGERRRVFAFEQDSQQFLDALDEEIDSCPFPSPPTVTNFAKEKSDDVAPVEQPPVEIVRKQIGKSNAIVKFECGPANSGKIDLVLLLDTSGSIYHTFDNEVSLVKSILSEMRKPIEDKMLRVSLIHFAERPSMAFSLRDELNRAEMIQKVEQIQFSGGITQICDAIQMGQTELEKFGRNGALKVFVLISDGHGHELWPHTMEIGKKLRQQNIQKFAVSMSTDYSKDELMAYIGDTNRIFVGFRQNLFDSTILAFLNQCVNHPSNSHAENAKGNESSTIAATTSVPSNEAKFTEIPNAQTSADGELTTSSKLPTTEQQNDDSSSATVETSTTDGTTNEQTTNATTETTSPFSDQTTLVNLPEETSQQTTITNMAQTADQGSDDQTSQGNSDQTPSVNVNDNANSTNPAQNADQVNGVQTSQGNSDQTPSVNVNGNANSTNSAQADQGSGDQTSQGNSDQTPSVNVNDNENSTNSAQNADQGNGVQTSQGNSDQTPSVNVNGNANSTNSAQADQGSGDQTSQGNSDQTPSVNVNDNANSTNPAQNADQVNGAQITQGNSAQTSQGNSDQGSLVNVNDNANSTNSAQNADQVNGAQITQDNVNVNDNANSTNSAQNADQVNGAQITQGNSDQTPSVNVNDNANSTNPAQDDQGSGDQTSSVNVNDNANSTNPAQNADQGNGVQTSIVNVNDNANSTNPAQAADHGSGDQTSSVNVNDNANSTNPAQNADQGNGVQTSQGNSDQTPSANVNDNANSTNSAQADQSSGDQTTQGKNDQGSSVNVNDNANSTNSAQNVDQGNGAQITQDNGVQTSQGNSDQGSVNLNVNANSTNPSPTNPTQTADQGNGDQTTQGSGGQTTNSDQTSLKLDNSSNSTNDEAKLKMIIMSSLASNSEHGPQAAHSTPNSTNAAAEQSVESATPTTQTLQKQPALPAVDLVIERPQHGGSHTLDDQLPFPDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY12</accession>
    <name>A0A914HY12_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HY12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5528.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5528.t1"/>
        <property type="gene ID" value="Gr19_v10_g5528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="148"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="240"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5528.t1"/>
        </source>
    </evidence>
    <sequence length="471" mass="52469" checksum="DBA6BD2BD1910C16" modified="2023-02-22" version="1">MILKRKNRRDGPNVRKIRRRADNGQVEGEESVDGSVRSASSSADEAADDQLQQKVVVDESRQSDNDGLATTRPVGLNEREVAPLMIKERIQEAVHVLANFKVRAEPGRKRSEYLKSLLEDLCSFYGYNEFLMEKFMQLFPNGAELLEFLDSNDQPRPVTIRSNPLKTRRGELAKSLISRGMNVDPAAKWTKVGLVVYDSQVPVGATPEYLAGHYSIQGLSSFLPVMALAPQPDERILDMCAAPGGKTTHIASLMRNTGVLFANDANAARLKAVIGNLHRMGVNNSVVSNLDGQEFAKIQPQSYDRVLLDAPCSGTGVIWKDESVKTSKDHVDIKRRFTMQRRLLLSAIDAVDARSKSGAYVVYSTCSVLVEENEAVVQHALGKRNVKIVPMGLEVGLEGFTKFREYRFHPSMNNTRRYYPHVHNIDGFFVAKLKKLSNEVKKPKPTKNKGKEAAEEGEQSDIDSLKRTSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY84</accession>
    <name>A0A914HY84_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HY84"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4892.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4892.t1"/>
        <property type="gene ID" value="Gr19_v10_g4892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4892.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19714" checksum="82136E73F6B1E000" modified="2023-02-22" version="1">MGQRASSLPHDEIAGIAQETGFSRNQILSLHERYLQLGGGRESLVRHDLQISEMEQNPFQHRVIEAFFLGENEINFRRFIGVLAALRPDAPRVKKLKLGFTLIDTDVDGYLTRNDLEAVVDCIVSDVAGEQRDSLVDRLMAEADADKDGKITFEKYCKALEQFDIVWRLSMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYB3</accession>
    <name>A0A914HYB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4915.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4915.t1"/>
        <property type="gene ID" value="Gr19_v10_g4915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4915.t1"/>
        </source>
    </evidence>
    <sequence length="720" mass="81895" checksum="E8A4BE9B76D330B2" modified="2023-02-22" version="1">MLFISAAINAMSSVDVMSNLLSEEAQINSGVLPPGSYQLLFWDKFVNRFYGNLETAELFTIDAIGNLKFKKGAFRMNDKKAISERFFQNRLQYVYTEENGEFTFNRSKMNENRPAHVYLLPLDNDGNLLMSEPGSDIAEQTDQMFSSGCLALPTVIRYHSLDRRNKIVLEMFERWLFGKSKLLSQSDCFFVEAYIRQMYKHLNGMIMNRREQHTTDQSEVIEEDFKLYSELGSMLSRALHSRQLADRVLMVGDIVGDIRMLCASIATLRAVQQHKSFDELGHWAKLCQNLDNLWHVAVSRAIDRWLTEAKGADQQLQMGDDNALSAVAEELSHQMQTIAQILEDGPAEHHQPEPFSLEEQLNQVPMLGPLGRKLETARQTNAKWTERVTAVSGMLQHLGILCKAKSAIAKECTAQSRWTREIEGWHSFCVHLKVARNFWVLRAVGRWLYGSKELRSDEQYLLEMQLENLVEKMEPDSPDGAMSLADFALLSRIGMELVKARKRLAARAMTVPGLWDQLTNICTVIEGFMARSRRPLATCWVEFCGKLEELNVIVVMNALERWRAGTPCKSDPRVIIEASKKALRTVRRVAAAAADRRGTPPMSGAESALLAELGAYFAEEFEMKKAATGPEGNGTTKVPSIISMEGMDKMLSEQCNRWAAFRRNIPPESRKMFVSWSKICKAIDLKEINNSEKMRDKIDEQMAEGQREVKDKRKEDEMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ90</accession>
    <name>A0A914HZ90_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ90"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g586.t1">
        <property type="protein sequence ID" value="Gr19_v10_g586.t1"/>
        <property type="gene ID" value="Gr19_v10_g586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g586.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33079" checksum="C296901D4613499D" modified="2023-02-22" version="1">MPMLLKKVCPSFGPRAMLKMLMDSKGFLLTRDGNSIPNICRPVERVQQEEAIKRQCGEIIQLKPILVFTEKGISDLAQEYLDGPLVNLEKATTVTVVLRGPSNDINENEHNIQDALHCVRKVRVVSGAEALEMALSHALEKANSIPCIRVGPYKAVAHALDIVPRTLLQNGGGSSTVRQLRGYSTIAESTANWTRENYAFLLSYGSIMIVIIIGIVALATTLLDSDKELATQFIALSGQFLTMKSENLDLKHEMRSASLKMEFNNLKMDSRLDHIDRRLDHIDRALSELAKNGANGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2A1</accession>
    <name>A0A914I2A1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914I2A1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6194.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6194.t1"/>
        <property type="gene ID" value="Gr19_v10_g6194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="48"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="241"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="842"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6194.t1"/>
        </source>
    </evidence>
    <sequence length="999" mass="113622" checksum="319B3F76B0F62A9A" modified="2023-02-22" version="1">MASSAVCNESVPTSKENLYTGNKYSSGYWKLHKERIKLPVWSHKSEFLAALEKHRCILLEAETGSGKTTQIPQWCVEWLRRRDPHKNSVVCCTQPRRLATVCVAQRVAAEMDVELSDVVGYSIRFEEAAGYNTLLKYCTDGMLLAESSHDEMLMRYDLILLDEVHERSMITDVVMGLVKRIMQRRPELRVVVMSASLKTGNFEHYFYGCRLMQIAGRSFPVDIIHSDCDSLLALDDYIDKSIKKAIDIHRKRDPGDILIFLTGQEDVEKGCEMLEEEAKKCVGCGKLNVIPLYGSMQHDQQRVLMETQYDGLEGRRRCIVATNVAETSMTIDGIVFVIDPGFCKRKIYNPRTKLESLLIQRISRASAVQRAGRAGRTRPGICFRLYTEHCYDKIMKEIVPEIKHTNLDSVILRLKKCGIDDIYGFDLIDKPSSDSIRLSIILLTDLGALDHSGRITTMGEHINILPVDPPLARMMLESVKLQCSKEVISICAMLSAPKCFRRPRGRQPQADQAKARYSDDRGDHLTLLRIFNAFVANQCSEDWCYVNFLSYRALQYADDVRNQLVNVMHQRLSIEVEGSDSLFPLYPHCVLKALLAGSFMKLAFFRSDSTGLHRNALKGYYVTVESQINLEKSGDGNHRYMLHPSSVLFKGKTYSCARPEWVLFNETIQHSEGGNQYLQTVSIIRPEWLLEVAPVYRSQISATSPEVDKRLREHENGTLNGMVREFEKLLLLLFGIWSSVVNRLNIIKTMSPKSIVSFLLLIFVLICQCNFAPGAEEGGGWQENAPTVVLSVQKSYGYAETPKADDVEKPDYSVCSRLPKRRRRACKMSVQIEVEARKAERQGLLEDDELPPPSQGLGLPSYRKPTKQEEEAQAPPKVIAERYACMNMTCLCPYLGGTSSGPDHCEYNAGASSNRTTRQSGNPNWNLGRVVRKEYRMLTDNERNRYHAAVQQLKRGFGSYEYNRIAYLHVDLRAMPSAHTGPTFPLWHREYLKRYILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2H2</accession>
    <name>A0A914I2H2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2H2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6241.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6241.t1"/>
        <property type="gene ID" value="Gr19_v10_g6241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6241.t1"/>
        </source>
    </evidence>
    <sequence length="453" mass="52266" checksum="230F59E9BC080305" modified="2023-02-22" version="1">MVLASPEGKFRRMSYPICEGRVDEAPTAAVRGGQRGFYEWLGDEICPRGRLFGLIRTSALQRKKFAVNEFIWGDKYSRQKALHLASQRTVDGQLQNVGPSRASSSSSAPVSRRFHAICEQNVPNLHVIRRVNDFLDGFERSFTEVEGQFEELNNDCGENDLAKFFRLVGQVQFRIGKRADTMTTCHERRHRAQLALLRHCAELFCQCQLSLWLHKPNNSIGIVDESTVLSELDEYLALLEPIKAFSVEIWQQNHSPDLAPNEWHYERNWLLSNKTVLNCARLTFHEEGENEPELITKWLHYNVADEQNAQNVTRFLNFPNGIQQDVLDTVLQNCVKRFDQANSIAERRSYVLSFHSIQPQQSFRSDNLCTAETLRMEAFGMENEAGNRTTPPNFYYLRRCATKELAGHLPDVQKIFRENFYTNNDGDKMFLRIPILQTGDGDKFEPPMLVFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4U4</accession>
    <name>A0A914I4U4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4U4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7530.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7530.t1"/>
        <property type="gene ID" value="Gr19_v10_g7530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7530.t1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40313" checksum="AD91012CFED19B07" modified="2023-02-22" version="1">MTFFKEVDNLSLHAADPVPALPDYLPNSIIYTINYALAVPPNLMLLYMGLWPSLITSRVKFPTLGMTCANLFGLSGFLLLNIVYLYVVCNDVRLSLFMCSLLRTVFYNTTYVCYFLFPVLAVDQYLYVCQNVELSIRSLKAVIAVCFAIPMAVAVYDLWLQEVILNDFMFAYIRMSPYTNAFFFFVLAPSFFAFSLICNLLVLFSIVRRQSKTARKQVGRSLNPRQLQQHKGIIYTYTLQAFLPLLLATPYYVAYLCFMFDVSIDLVWFVIGEAIISLHPLTNALITLFLLRPYREALKRMRPPFAHRIPQLLCSSSQRSTTTVNRSGYDSIGPTTADDLAILGGLTHGDGTPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5D4</accession>
    <name>A0A914I5D4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5D4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6936.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6936.t1"/>
        <property type="gene ID" value="Gr19_v10_g6936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6936.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9244" checksum="091FC610A45A9DD5" modified="2023-02-22" version="1">MCRNICARPTFVFYLMLLKKSMWVVGIINVQCVQAVRILHRGAYLNAPKAVQQPVRKCTLFLPWNYCKYGSFVWLLCSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5P3</accession>
    <name>A0A914I5P3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7553.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7553.t1"/>
        <property type="gene ID" value="Gr19_v10_g7553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000031">
        <property type="entry name" value="PaTChed family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF6">
        <property type="entry name" value="PROTEIN PATCHED HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="990"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1235"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1279"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1320"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1349"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="671"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1404"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="942"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1406"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1472"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1499"/>
            <end position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7553.t1"/>
        </source>
    </evidence>
    <sequence length="1536" mass="169956" checksum="89536F022971F3C9" modified="2023-02-22" version="1">MLRPKESNAGSQANAEEEECHSLFGMAEQRQEHVEVDEARRMGSRMRKSCQCHETDGIEKTLSMSLNVWSLETLDQTYQSALSSPCCHLNLLDKYLVGKNDPADFSKAWRKKFSKHPSWCDADMCLQQINAGNALLFHLGEFVQQWPKSIVVVGLVLLTVCSFGLKDAIIETDLVQLWVERGGRLDEEMNFLSNAKSDYRKRAKRSEVRQSTQNSPIVAQTNQTAPFTRSEGNAVELPTENTFGGGFQVVIQTPEVPGENILTREGLQRHVAILEQISKYSVQMFGEEWHLSDICFKPPPPASSKDLLAQFMEDIMSQIIPCVWITPIDCFWEGSKPLGPFPEYDLGPFSQFVPSVPNGKLSWKSLNPEALLNATRSLVDVGMIGELFERAGIGMAYQDRPCIDPLDPDCPATAPNYFNRCGAFEHFSKWNAKLPTQHRVVLRPPDIVGKKTISKRESTNSTTTSSKAAADGADAADYYDNDDESATTTTEAPAQRAQREKQRDCELYGRPFIEWLSANRERIHEFIDSAEGDNRRLLPVYPDYGQVLTGGCRGFGKRIMSWPEDLIVGGIRRDAQGFNIRHAEAFQTVFLVASGADVHQRLTRSKNHRLEKLGATFTQAHAGAIIAAWQRNFTRNIYDHVLNKPDQSVRVVHPLASTSIQDMLEQFSEFQFFVIFIGYVLMIIYAGWSQLHWDGWWFSAKSSCLLAIIGVLVITLASVAGLGLSTVMHIHFNAATTQIVPFLTLGLGIDDMFLLLHNYNDVLEAVRQKEVAVLLKETGMSVLLTSINNILAFLTGCMLPIPALRSFCGQVAILLTSNVICIILIFPAFIALDLQRRKAGHRDMSIAFFCCCCSSSSNCFTGANKGSGGIGTEKGSDKCAKMMESGGIRKRKLEECSSRNQLVKTDSTVTTYSSEIDLQQMSAVVFGPPLSGQLMMSGSGGTSSSSPSSTPKKSASLISSASSTTKWYTLSGFLHGYYIPMLRRPIAKTIVLLLCAAMFLFGCFGLYYSGIGLELADVLPEHTAPAAFLKGPRVDYAQQQHKLEQLRRDIAKSNFVIKVDGEPEQWWMMFMRTWLQLLQSSLDRAANVGIWPSDDLKKTAADALARNFTLSDDFFLARKLLCSVGHRFNCTETHGTKLIEDGRINPKGFYNYLTAWFYQDNMMYYVSQAAFFPTPPPWHFSATDESAVPPADALLYSQIPFYMNGLTDTPAIVEMIKEIRAILPEADLLSNIRNFAVLLVISLIIFNPWAAVMVAIIVVTMTVELAGFMGVFGVKMNPISAVTLITAVGIGVEFTAHVVLAFLTSLGTRDERMVACLEHMFIPVIHGGLSTLLGIVMLAFSEFDFVIKYFFVVMTALVIIGLINGLALLPVLLSLIGPPCEITPVDGSNLLPCPASARYRPEDSPNCFNPSSAHEQQPDEQKKRRGCKRMLAVDDSSSSSSAEDGGDAPTFGNGSAAAVDESERSLQQNTQEGRHGQHNYHESLSTLYEASGEEREQQRSTPPKSSNSSAGEEDAIGKTNRTFSSLAAKAIVKQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I641</accession>
    <name>A0A914I641_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I641"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7664.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7664.t1"/>
        <property type="gene ID" value="Gr19_v10_g7664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7664.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20759" checksum="DFAA21CD416649A5" modified="2023-02-22" version="1">MKSRNNPYGGKPSGKNLSGDEDEIEKFYQVEKILDCRTSSDGSVEYLVKWRGYSSDDNSWEPASGLYCPQALQAFKASRSVTRIGQDSVPKSADQKRSRYEKSNKDNVMKTLKDSYFLEEAGVVPDVILGVDRYRAPGDSEIMMALMSYTDGRVEFVPTKLLRNHTVAAIMLIDFYEQRVHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I657</accession>
    <name>A0A914I657_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I657"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7254.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7254.t1"/>
        <property type="gene ID" value="Gr19_v10_g7254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7254.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15737" checksum="0EBBB16C1612E999" modified="2023-02-22" version="1">MVEFWEEQRQRERLMMRQTDCPPQQEGVEEFMDIYFAAGAALCLRTVVATAAAGTMPNAILPTLARLDIDGVTASEALSLILVRSVAMHRKRKWAKSAVPNTATMQMNDDVRRALSVISEQKHFVITQIDQLSVVLQSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6E8</accession>
    <name>A0A914I6E8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6E8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7929.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7929.t1"/>
        <property type="gene ID" value="Gr19_v10_g7929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="182"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7929.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43346" checksum="33D4BDFA253E4532" modified="2023-02-22" version="1">MSISTESTNAKDITADQVRPPNVANLDPSEEKRLLLARIAELDRQQTTNSPTSSASVDLVARKRRRIETSESFAKQLEQMEEWKRVAKLELENKTLRAELEHQKLLENQQPLQTKMEQYQKLLQQTIDEAAEMKQLNIKLQSDQKALLERLAASDQGINQQQKELSAKMEQYQKEQQLNVVDLKNTVGVLNDKINGKGLIPQQNRWNATACHKDLTLSKPEQLIVQYKGKKLGQRSVRAELPIPKGKFGIFYFEVKIIGAGDSVHIGLGTKLMPLDEIFGAQEGVYGYGSWGAFWGHETEGCSDWNGWPCFKEKPEFGAGDVIGCGVNLATRQIIYTKNGRRLETSRLFVDFADDLFPCVTLSDSGDKIEANFGPNFKFNIADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6X9</accession>
    <name>A0A914I6X9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6X9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7474.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7474.t1"/>
        <property type="gene ID" value="Gr19_v10_g7474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7474.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22601" checksum="1C6040D09DE3941D" modified="2023-02-22" version="1">MNSEFVRSHCKRPKSLRRTRAVPKSSRVRFSTARASGSCAWTSPKTALTTPSSNNSSQWPATRKLSNGVTKCSPVSPFTEGRAVLHTALRNRSNAPILVDGKDVMPGVNAVLEHMKQFCAEVTSGKWTGWTGERIKDVVNIGIGGSDLGPLMVTEALKPYQVGPNVHFVSNMTHLAEVLKKVEPKSVLFIIASKTFTRAAATPFGPPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7C9</accession>
    <name>A0A914I7C9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7C9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8182.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8182.t2"/>
        <property type="gene ID" value="Gr19_v10_g8182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF131">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="185"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="566"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8182.t2"/>
        </source>
    </evidence>
    <sequence length="602" mass="67777" checksum="5F03AADA206657B6" modified="2023-02-22" version="1">MDDVTLRLTDSGNFFEMRGKGSSSSSGRSVPQHRRPLPLLPPLSFHSLLLFTVLFLVVPILPISTDKSKSAVDGRYKVYQIRPDSEEQLVELNKMEQQGTIDFWRPPPSVNATGDVMVDALRNGRHFLEFLREFQVEAKVLVDDLSKLIEEKETGPSAHTKLAKNGPILRDNFDRFDAFGLRMGDYHSFAELLAFMQNVQNAMPNRAQLRTIGWTAEGRPLQGIQFGNPSDKSRPVVWIDAGIHAREWTAVHTAAYFIFYIANQIRLGQDQRLLKCLERLDVLVLPCINPDGYEFTRSEPRNPAVRMWRKNRSKERCATSARDGQTHCCKGVDLNRNFDFKFAGGGTSFFPCSEIFHGDNAFSELETRAVRDAIIGTDLKGRVPAMITMHAYSQLWIYPFSNRRGAYPADVEELKAVARRAVTAIADKFGTNYQYGTGPETIYAYTGGSADWAKETAKVKYTYTLELRPSYYSVSAWNGFVLDRAQLIPTARETYDGVLVVLEQVAREMVEQTVPNPNTAAPFVRRSIAPAPLSARPSNSFSTDEDESLRVSVPSRALPRRIGSRCEDALPYCAAWVSANERICVDSKATMERECRKSCKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7D5</accession>
    <name>A0A914I7D5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7D5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7595.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7595.t1"/>
        <property type="gene ID" value="Gr19_v10_g7595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF344">
        <property type="entry name" value="SYNAPTOTAGMIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="140"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7595.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30084" checksum="C50F6070E8974F93" modified="2023-02-22" version="1">MEQLAACHLMNGFVHVPHAGNRRGHHASAPSCQHVKRTLSLADRRGLISPARGSARTGASKADDEWEGVARRMHHAGHSFGHMQNWAMLMPMVEANRVLHLPSLEFGAGRRYLAGSRRRGRSAAASARASDASCYWRREQLGQLLVCLQYSQQRLFVDVLRASGLPDASAAPSLLVWLLRADLGALEKRKTANVSPKIGTAPVFNERFVFAAQPDELDNLAVVIMLMDSFAELGHCILGELSGADESGARHWHEAIERPGHTVAEWHRLSAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I814</accession>
    <name>A0A914I814_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I814"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7496.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7496.t1"/>
        <property type="gene ID" value="Gr19_v10_g7496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7496.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27031" checksum="844B57AAC2F86965" modified="2023-02-22" version="1">MTRGSSAGYDRHITIFSPEGRIYQVEYAFKAVNAATLSAVGVALDDTAVIAVQRRIPDKLVDPSSVKSIYKLSSTVSCGVIGIVPDAVFQVRRAQSEAAKWKYENGYEMPISELARKMAEINQYYTQVAELRSLGTLMLMVSFDDEKGASVYSVDPAGHFISVRGYGIGVKQQLVNGFLEKKLKAKDRKFGEAEVIQLALEALQHGLGIDLKSGEVEVIVEKKATPNGEKLDSKSIEEHLTAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8H9</accession>
    <name>A0A914I8H9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8H9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7703.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7703.t2"/>
        <property type="gene ID" value="Gr19_v10_g7703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036918052" evidence="2">
        <location>
            <begin position="25"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7703.t2"/>
        </source>
    </evidence>
    <sequence length="333" mass="36113" checksum="CF82A0EA77028C1E" modified="2023-02-22" version="1">MRPLCILLCPLIFVSFLCNGNGSADPLTGALRQFAYNIKETVQKFLCQLYLPRISQSPDGALSFQLDQKGVPSDNPLFSPQPCPSCRLIPSQLFVGQWHISLFSRDFRLSVLTDLDSMIDRLEAGLPISSRKSFADLVTDPPDPFFLDFVEESAKCEIFYHSPGGKVKSVVGFWERLPSDGSFVWRIGQIAVAQFCVVHFTSELNILSLLPSLNSTLANVSASFNMNGTNVSSSSASSSSSSSSSSSSSSSSSSSSSSSMSVSSSSSAFVLLNQIDSWPRCDNFVALSRNLGQESVDGLKQWVEGQRRLLRPESALNAMEKAKCDGLGLIPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9A9</accession>
    <name>A0A914I9A9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9A9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8087.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8087.t1"/>
        <property type="gene ID" value="Gr19_v10_g8087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8087.t1"/>
        </source>
    </evidence>
    <sequence length="490" mass="52506" checksum="FADFABAC2CA78F65" modified="2023-02-22" version="1">MGNLASNYDDSPWLKACGEGNLDTVENLVKNGQDIEAAHSDGATALIVASNFGKVNVVHFLLSKGARVDRTTDNANSPLFLAAKEGHLEVCKELVAKGADANQELGHGWSTWLAACANGHLGIVELFVENGQDIDVTNITGFTGLIIACFDGHADVVRFLLSKGARVDCTTNKGYSPLFIAARDGHLEVCKELVARGADTNQESGDGLSPWLEACQNGHLDVVEFFVENGQGIEVTNSDGATGLMYACNEERANVVHFLLSKGALTDQTPNDDNWSPWFLACNNGHLDIVELFVANGQDINITDSAGDTGLIIACLDGHADIVRFLLSKGARVDQTSDGFSPLFFAADGGHLEVCKELVAKGADVNQKSEDGQSPWLAACANGHLGIVEHFVENGQDVDVSSSNGFTALLIASRSRHADVVRFLLSVSVCTNRSDAKGNTTALARLQRKLNSYQQQLKQLLVLLSSCLHHSLLLLLQTRQNPSTIVLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9X8</accession>
    <name>A0A914I9X8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">imidazolonepropionase</fullName>
            <ecNumber evidence="2">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914I9X8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8854.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8854.t1"/>
        <property type="gene ID" value="Gr19_v10_g8854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="9">
        <location>
            <begin position="52"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8854.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18218" checksum="A0FEBDE2280F67FF" modified="2023-02-22" version="1">MEEKKRKRRCNRRSNESHLEECSPEGIRALSRSGTVAVLLPTTAYVLRLRPPPVREMIRAGVCLAVGSDFNPNAFCYAMPTVMNLACVQFRMTMPEALVSSTLHAAHSLGRGQTHGAIAVGRVADFVVLNKRNWEHLIYRMSAHHSIVSHVIKNGIIVYEKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAS6</accession>
    <name>A0A914IAS6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IAS6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9097.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9097.t1"/>
        <property type="gene ID" value="Gr19_v10_g9097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9097.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39842" checksum="1B87F513F0585005" modified="2023-02-22" version="1">MSDGDENLVYLTFKDQRPCWLLIAFAVPISLISSIGILLNFSVIYVTFKSKNLDGVANYLLALTSFFEVLQQFGSFLFLYTAISGTNFIDYSLAVQICALSLFGFGGVPICMFFTGVDRLICILAPIWHNSLRKRYYLGTILAICNFCGIMTALLFFKTAMDIPNLKLTGELSGLVYGDAGKYFSIYSFVFYSLTIAIYVVTGVWIKFRAQGGTTPNNQTNRRIFRSLFIIILMNIGGYFLMTICENFVLPKNTFASVWAWAFKKIVALPLNVSASSSAVILYVTSNEYRKAFGDEFGKVMKLLAFVIGTLPPPLLPCKFGTYNRRSPFQQQKWTMEAINGRPFLCRFRKKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB26</accession>
    <name>A0A914IB26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8245.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8245.t1"/>
        <property type="gene ID" value="Gr19_v10_g8245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8245.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41597" checksum="74FFDE904EFDFCBD" modified="2023-02-22" version="1">MTQPSQFSSGHRLLGVSVVYSLWDCFIGSLLSYSLWDCFIGSLLSYSLWDCFIGSLLSYSLWDCFIGSLLSYSLWDCFIGSLLSYSLWDCFIGSLLSYSLSDCFIGSLLSYSLWDCFVGSLLSYSLWDCFIGSLLSYSLWDCFIGSLLSYSLSDCFIGSLLSYSLWDCFVGSLLSYSLWDCFVGSLLSYSLSDCFIGSLLSYSLWDCFIGSLLSYSLSDCFIGSLLSYSLWDCFVGSLLSYSLWDCFIGSLLSYSLSDCFIGSLLSYSLWDCFIGSLLFYSLWDCFIGSLLSYSLWDCFVGSLLSYSLWDCFIGSLLSYSLWDCFVGSLLSYSLWDCFVGSLLSYSLWDCFVGSLLSYSLWDCFIGSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBE6</accession>
    <name>A0A914IBE6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBE6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9033.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9033.t1"/>
        <property type="gene ID" value="Gr19_v10_g9033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037594238" evidence="1">
        <location>
            <begin position="27"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9033.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="54918" checksum="9C284CA3DF58DB4E" modified="2023-02-22" version="1">MNSFYWAKTAFVSLLMISSITFEATCSGPVSESFNSLIVGITSANEGEHSAASISNQRPLELKLADAQMLQQWIGQIARKFVVEDGIFAGNYFISDFVIGAVIKSPIEQLKVDKIILKKNNRRHIQELALLNSSKTEMTPTDVINFAYFITTQFLKFSPTDSFESIFQWTKWGPSFGTLRISSFGEDLIKYRRIAHQLLLDLKNCGPEELEEFSLKKSNEFSANNCKKEKENDGIENSKIYPFFDEAIRIDWNVWTEIIQQIDELTKTVKSMDTKQVAEYLKRANENEGPMKIVKAKFDEKKFGLELKADINVEAQLFELFFSFAARLEAIVHGKNIDGTIEESRENPKDKIRAFLAVPNCLNVQEWANKFSIFDYWMEIKEINSKESQKMPVIGVAIYKELFNEARSRLQKNYKMLKSLNEQKFSIYEERNGRKVEETKIALLNNVRYDLVINFKLNAWKDVRDRTAAQIYWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBN5</accession>
    <name>A0A914IBN5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBN5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9349.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9349.t1"/>
        <property type="gene ID" value="Gr19_v10_g9349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9349.t1"/>
        </source>
    </evidence>
    <sequence length="454" mass="51564" checksum="4F6D48DAEDC77FAD" modified="2023-02-22" version="1">MDERSAACHNFIVISAQQNKKLSIFVEVLVRVVVVMDVDECGNFLCCQVHPSLFAVQIGTFWRFISSAGNLALVCRSNWHILAFHLIGGQSGISLPFKLAHFGVLSHRREQSNDDSLCRISESSVLYEKFCAVLDDAHRVRNGKEWLKLRENNKQPPTEDKNGAFAEWSYRYYSIERFFDYCYFLKKSKVCEFSIELVQKKRPFVCKCKKICAPYENTKFQHIALKPEFKYERGDPMSIGDAMRKIVEAYQKLYPGNLQKLQSLISRQKELPKMDFCNKEDCIKVHAWVYYAKNGGDSDVATPKLEQIQKHLLKNVPLNLKEFPPQPPQNEKQTAEKPKIKLPQNYSTSSSSSPRGHYQPNKTVLVTLEHPVQATTVVVLEVAMVEVVMGSIVILVVWIVLPVRGRTSSFAASCVRASGVGINANCSLSASVMFSTLRWQVYQPEHLAPSLPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBR3</accession>
    <name>A0A914IBR3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBR3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9133.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9133.t1"/>
        <property type="gene ID" value="Gr19_v10_g9133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.50">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016133">
        <property type="entry name" value="Insect_cyst_antifreeze_prot"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51156">
        <property type="entry name" value="Insect cysteine-rich antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9133.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12751" checksum="28548C505C0088E3" modified="2023-02-22" version="1">MGLSVSPMADQLLWADQLLWADQFLWADRLYGLISCYGQINCYGLIKCYGLINSYGLINCYGLINCYGLINSYGLINCYGLINCYGLINCYGLINCYGLINCYGLCYGLRIPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC17</accession>
    <name>A0A914IC17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IC17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g881.t1">
        <property type="protein sequence ID" value="Gr19_v10_g881.t1"/>
        <property type="gene ID" value="Gr19_v10_g881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g881.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16314" checksum="D789572D61628A4A" modified="2023-02-22" version="1">MEDFDVNQEMKANKILVKIENAESVEAMNEGGTSMEAAAATTNEKPEKASHKKAKNGRKKKKRPRGGKKFKDWLQKEEERKRNEANALKNREGNEGENCGGKMKGSFEDDRAASISSINAKKGLRNFALHRIQKRKREAGKKGPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC26</accession>
    <name>A0A914IC26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IC26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8817.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8817.t1"/>
        <property type="gene ID" value="Gr19_v10_g8817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8817.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39504" checksum="ED5876A366C3E0E5" modified="2023-02-22" version="1">MSQPEQSMDQQFGYCEGVVDDLLKGRLGDSKSSQRNETLKNCMRMLQLLSEAVERLALFSANEEADEIPTNSLRFLLIPAYLASALQEINVEMDKRGAYLRASKKHYREFLESLSLFGLINFRLPWLDEENRPRDQGEGGGRLIGDSFEEAKARRQRTVSRLQQLEQLEKTLERLKNEKRRNDDEAAQREIIYTLLRLWSVRSVKELDMIEEELKMVEQFEMRNSHPTTFGDSACTSNDSKSAEPVRLKPFIIARSEAQKRVFGLGYPSVPTTTVDEWYDQTFGNGAKPSSFNIGQRKTDDDDDEEEDEEEETETKRRAQIRRDEWKDMNRRGCGNTYNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID79</accession>
    <name>A0A914ID79_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ID79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8826.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8826.t2"/>
        <property type="gene ID" value="Gr19_v10_g8826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="77"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="774"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="616"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8826.t2"/>
        </source>
    </evidence>
    <sequence length="852" mass="93808" checksum="1C6B0FA7AD4449AA" modified="2023-02-22" version="1">MDGGEKPSLAPSASHVFAPPAPLASSPAPFSPNSAPSLGDVLLNFHSSHLPHSQPSEVQLFIYGFVLVLIPTATILGNVLVIISVLRFKSLHSAINFLILGLAIADLMVALFVMPYAVYVYVQGGRWLLGPLMCNLYLSSDVACSTASIILLALISFDRYQAISHPIQYSRQAQNIARVVRLFVGVWVYSLLVASPIVLGFNDPPPPDNTSGVFEPFECRFYSPWFSLLSSLVSFLLPCCVVIFVYVRIIRALRRRERAAKARKQAAANSAAHHQQATASASERAQFTSGQQMESEEAGEIVAGPAINMMMIALPSLNRQMRRYERHRRALEEAAIAEDELSSSDSLSDDVRILTNDFFSEVLTSNSKASASLEPPGGSHTNASLFGGFRASFSGAMDLRKKSMAEEIVPTIFVPRKRSACDFGTFSSPREVLRKNTAPMKIRLASVRDANSERRENEMIGRCQLLSPCAGSVDWSAPTSRKNSEMPRGNVQQQRRHRQQHVTARRGALSFPLVRRIALGRDIRVNHYLLNDGEDTSEDLIVPDRTTTTAVLHMSNGGGRVLLGEAEVQSVHRQNGGGESPKTRNGAFFGSVSFRGPSLAVPSLPPFRRGNSAIELGGRRAAEDDDDSKELPKTTSARMANDNVTKEAEQNERARNTVVLSADTVPNSLRMPKAAVTGTASLGTEKPPPPPPAPRVAVAQQQSEQGSRRDRHASLRRKVHKSQRKEKRATKTLGIVVEIDWPIFFGLSDDSLIGMDQIFVLTHSFCPNRFAEGTFLCCWVPFFSLNIANALCVEMDAGWCQIGFGPFFYSTWIGYMNSFMNPVIYTIFNAEFRRAFKSLLLGRRGNTFARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDE6</accession>
    <name>A0A914IDE6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDE6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8855.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8855.t1"/>
        <property type="gene ID" value="Gr19_v10_g8855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037272556" evidence="2">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8855.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23229" checksum="83FB0EE7F16B820F" modified="2023-02-22" version="1">MPSAATVFIPLLFCYFFPVSPGNIFGSTHLLPLPLTSNAYGTSSNQQSSSHDRSLFPRHSPRWCPERLRHLCCTGFKSMGRLHSLRLSGLADRMMALLDQVEEWSARMGWDSSMVGLVIGADGFVRWAIRNAGGSSASWDIYFIAQLAELVESPEKVRRWYRTVEGWVRNGRAVMNRMKVRTIGSEGRVKQERESELTFPDEKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDQ3</accession>
    <name>A0A914IDQ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein L23/L25 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDQ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8939.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8939.t2"/>
        <property type="gene ID" value="Gr19_v10_g8939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8939.t2"/>
        </source>
    </evidence>
    <sequence length="73" mass="8392" checksum="81098E49110D62A5" modified="2023-02-22" version="1">MRMKGRKKELVCAEGKAFSAVFDVRKNQRCLQRCISRLFSTKLILRGYDTTDNTTHSSGDEHVRSGPKGWTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE58</accession>
    <name>A0A914IE58_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IE58"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9065.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9065.t1"/>
        <property type="gene ID" value="Gr19_v10_g9065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037317798" evidence="3">
        <location>
            <begin position="36"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="296"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9065.t1"/>
        </source>
    </evidence>
    <sequence length="667" mass="75443" checksum="A34E50F6F7E047D7" modified="2023-02-22" version="1">MAPAPSQMASSADLTLNLATVFVVLLTQTVQFCSCQPNKSPLSSLTSSDDGFNAKELCRAIEGTEFHEQCLHSEVVKQKGFIPRHLRPPWLNSSLFEDNQLPEEKALANGCYGCYKGSTASNGVNPDEEYCACAVHFYKNKPETEPDDYKDRTLVLLDGCITDIGAASTFTFPLEFRHWGCRSRWHQLFELWERPYYDYIMIIISGDFGTKSFSLPQLTSFRGRVQEMRGLHLDLREEVAAVQWRDQFGAYDYVQRNDLCWQPTDLKLINDYGMPNPELMYPHFVTKSIGHVNFSVDIMKMFYQHNKKNAVQSPLSAAIALAMAYIGARGQTAVELGKVLAAGDSSGPSLRDNYGKFLQEIGSTQTDANFKLKISKKLYLSNSVKVLDEFKLAIRTHFGEDSFESIDFGQQIEVADKINAFLDKASPGGKSIESIVPQSLNPSDTKLVLVSAIHFEAKWLRQFNPQYNEKKRFYSINGQEPEMDMMTQTGQFMHMETEDFELLGVPFVGEKAHFVFLLPKPKRHWDYVFQKFNGGNLVEFLKKSTMKELKVILPKFKIVSLHQNLDETLLSLGIKRAFRPSKADFSGINRNNLSYTLYINKVIQKAHFSIDEYGTAASPSESKSIGSSFGLPQLSFARTFQPDSPFAFFVTLHKKHVIFSGVFTGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEW3</accession>
    <name>A0A914IEW3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IEW3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9271.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9271.t1"/>
        <property type="gene ID" value="Gr19_v10_g9271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9271.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38104" checksum="6E781C12E9204B5B" modified="2023-02-22" version="1">MNSTEDPSFYDAFKDDDFPIGFIVICIVRLMLSIVGLIFNGALIFVTFRSRRLRSRCNALLAFDAACSGIAFVCNFVTFAVVCSGKKFIELRQCFWLQFLPTIAMSLLLNSMLAVGIERLVSVVAPFWVNTLNSTLYVGTLILLCFANAVYTMVRLYPISLIETPDMPVTCTINDLYQGEVGMALFGNAMLFTGLTILCYAIIWATLRFKKAKQNTDQTQIDYTKRIFKCLLVNVIFVSTGYFLNVAVLILLTRISLSQVQIVFATYILGIITGISAIGTVPTLYIFSSDYREAFNEKLFRSAKQAQLLATVVGLKAGHAVATAQNGVQNVRRVPVQMASTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPF9</accession>
    <name>A0A914GPF9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPF9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10125.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10125.t2"/>
        <property type="gene ID" value="Gr19_v10_g10125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10125.t2"/>
        </source>
    </evidence>
    <sequence length="309" mass="35446" checksum="5B22757BE86E5A2F" modified="2023-02-22" version="1">MEAIFICADVWHGVFAFLDPFELGLKVALISDRLDILVDVHFKSREWSLGSMEIRRAIGGNGAQIVVKRSGERFGERLPIPREPIPKNVIGFECIWISSNNQRRSWEIIRQKIWPLVNDNICRLTSFRLDHLRQFSPAILCNCPNLQLIHSFDLFPEFPDEDNARASSAQAMAKWLITPRGDDSKGENYPYVEPFELKNNLTRERLTLRQIDKDKWLLVRCPSVREEDKWTNWEEEAIEWQCGRQQNCIAITYSDRDIGEGMAEANDDICGSDICGPDICGLRQNRHLRPDICGPDICDPTFAAQTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRZ5</accession>
    <name>A0A914GRZ5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="9">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914GRZ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10729.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10729.t1"/>
        <property type="gene ID" value="Gr19_v10_g10729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10729.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="53848" checksum="285BB11085C6919F" modified="2023-02-22" version="1">MHERAEVVDTVHTRPFEQIGLFSGYLSETAASLVDQKLGLNVVPRTAIVALAAPTFNYGRIDRTVTSTKEQIARNYPDLGRHFKRIGLPPKRGSFQLFVHGYKDAKYWLDQWKQYPEQAPPKPSQKEFQLQFENMVVLDYIIRNTDRGNDNWLVCYTPATLASEEGVQRRRRVSSSSSGELKRSDSLKQLKEQLGNEPAKFMEDGKLIDINEPGTDNAESGGSAFPFPFCFESPNDNWEDVNMPRVKIAAIDNGLAFPFKHPDQWRAYPYQWAKLPMAQHPFSEETVQKILPLIDNTDFVRELGNDLRNVFKTDKGFDKKTFVKQLSVIYGQIFNLREALRTRKTPLQLAQMTPQYMIEIKKKRKMQPSSNSSESTNANKVGASTSSTAGGTARQQKRTTYDAIIVDVETTSSVHEDGDASMAMTESQMASASTASYSRLVGPAPAQTPNELNDPKAWPNVFQQKVHTRFPLFSCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUU4</accession>
    <name>A0A914GUU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g114.t2">
        <property type="protein sequence ID" value="Gr19_v10_g114.t2"/>
        <property type="gene ID" value="Gr19_v10_g114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF55">
        <property type="entry name" value="POTASSIUM_CHLORIDE COTRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="143"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="430"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="8">
        <location>
            <begin position="839"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g114.t2"/>
        </source>
    </evidence>
    <sequence length="1116" mass="123198" checksum="928EDAE3B401AA7C" modified="2023-02-22" version="1">MGNFGFKQIAKHNTNGPHISRPKSVVKKVRSIMEERRRRFSTAQQINPDTLKVIKRAAARLESIVDEADESSTDKEPYQRKQSIQNKFTAKLGGLALFKDEDEDEISMAAGGASFISAYTTPGPKERATSAKKKANLGVMFGVYLPTIQHILGVTMFIRLFWVVGVAGVWHTMLLLLLCCACTLLTSISLSAVATNGVVESGGAYFMISRNLGAEFGSAVGILFYLANTVATSMYLVGGVEVFLLYIYPGMTIGGEAVHSDTSMFGMMSHNYRIYGTLLLLLECVIVALGVRFVQLLAPVSLFCVILSILACFAGGIEKAVVGDGQHVCMLEDHLLNSRVLNIPPGEDILNICKYCKKGDHIADEFCEGNATTEVCQTYTSGNLKCVNAFPGLSSALMHANMNPKYMQEGQAVERERDADRTREVFQDVSTSFFLLLAIYFPAVTGIMTGTNMSGDLKDPQRSIPSGTITATLTTSFIYYALAILFGASIIGPVLRDKNGKSLDGSLVVASMSWPSPWVVIVGSFLSTFGAALQCLCSAPRLLQSIAKDNVIPMLAPFARVTKNNEPFLGLLITTFIAELAILLGAVDAIAEVLDFFFLMCYAFVNLVCALHSLLGAPNWRPRFKYYHWSLSLAGAFLCFFIMFASCWYYALVSCILTMAIYKYVEWKGAKQEWGDGLRGLALTTAQYSLMKVEDKNPHPKNWRPQLLILVDGKYSKEMIDLRSLNLLNLAGQLKAGKGLAITVAFLRCSSTRSNVLENRKKADEIKDRVQQDMAQARLRGFGKALLYTESQMEGCVSALYQSIGIGGLRPNTVFLNFPRMGDSDDHHKEQRIFADQLGCGAQNENCMVVVKGITDFPRPNDRLRGHMDIWWIVQDGGILMLIAYLLHQHKVWKGCKLRIYVIAQAEEQNEEMKHRLQRHIYMLRIDATVFIVNMIDPEGVEDDAVQKTLNMEQRTRTLMKKNLSGLSNGGLANGGFTPDERFLSGRNSPASGNTLAVPNSQSRPVTKDTVIETSFIQKAFQEEDNNDTISSNDQISIRDIDDTKVQKMNAAVQMNQVILEYSTDSQLVLLSLPKPPKSIQALVENYLSYVEALTEGLPRVMLIGGSGKEVITADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV99</accession>
    <name>A0A914GV99_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV99"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11506.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11506.t1"/>
        <property type="gene ID" value="Gr19_v10_g11506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11506.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15728" checksum="108DABC80E7E63CF" modified="2023-02-22" version="1">MSNFGVAKTNAVMSNAGDACTHRSTMSARRDKWVFPVCHCLLTAKTQATYERMFDLLQQCWPTFKPRVASIDFEQAIVGALQAKHPQCDVNFCLFHLVRNMKKRVAEQGLTHLYNTDAAFSQCARMITSLAFLPVADLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWB8</accession>
    <name>A0A914GWB8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWB8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11363.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11363.t1"/>
        <property type="gene ID" value="Gr19_v10_g11363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967">
        <property type="entry name" value="GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967:SF10">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037457775" evidence="1">
        <location>
            <begin position="25"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11363.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="39021" checksum="78CA452BD57F3BE1" modified="2023-02-22" version="1">MHQLLFRPFHLFLLLLSILFYTKICRIDKIQAFLTEQSALLQGKEMAEYVKPFREVIERVGHNSPAILILNQHALNITLNFICNLRLFPGASERLIAVVFDHNSEIVLRNSFPHLNVIHWPLKALTDKFGSGDGRYQLFQYFRAKLAAFLTELVDSFWMVQADTIWRENLFKLIDVDNDTDEYRRADLIFDSEGTDGLLSSMIPYRLLSNWRHSYGSNDKEDRPALFQFDGGDNAGDKFNKMRAEGHLFVDVNTIDGWKDEKGFGRVAQCLERKTEEVARAADERGHRKGRERRRNWAMSIIHGLFEWVYGRFPGIKRFLITELFPHYAAHFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H022</accession>
    <name>A0A914H022_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H022"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11983.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11983.t1"/>
        <property type="gene ID" value="Gr19_v10_g11983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11983.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15280" checksum="3C7078EAE7F89520" modified="2023-02-22" version="1">MCRVFQVFFYISLAALCSTAFNIPFILGNVGFTKKPNGQTQVDLNSGLNIGGNGAESGMKFNFGNGSFNAQSGGGVLIGGNKFGTNSTFGVDKKGLVADSDVHLGNNKTLHGGLGKEKNFVDDLTDLIRRRKEEKRRKSVGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H032</accession>
    <name>A0A914H032_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H032"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12807.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12807.t1"/>
        <property type="gene ID" value="Gr19_v10_g12807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12807.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21012" checksum="0AE63FEF5593A3F9" modified="2023-02-22" version="1">MGNRRRALETRRSNRKKGTVPEAKAKKRWHRVRRSSVSSSVSVRLQLHFARCSRSTKWGTTADDQTDSYSDLSDLDVFSSSEGGDESADHHQQQQQRKKNAHEDGGGVKATGEEKKKKKRHNHRQQQQHSLDTFITAAFAHRDLTPPELALGYALRQHCRNDTANKRYYVFPRAGRVFERLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H041</accession>
    <name>A0A914H041_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H041"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12389.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12389.t1"/>
        <property type="gene ID" value="Gr19_v10_g12389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12389.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="8923" checksum="35871E3EDAAB6608" modified="2023-02-22" version="1">MIGIEIGSLELIHCTSLTVGAAFAVTIDHPGCAADVRWTATTMWPGPNEEFGRSFCCSSQGCSGSSEIRNQQVGLTGFSHRADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0C4</accession>
    <name>A0A914H0C4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0C4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12873.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12873.t1"/>
        <property type="gene ID" value="Gr19_v10_g12873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378:SF2">
        <property type="entry name" value="MUCIN-5AC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037409869" evidence="2">
        <location>
            <begin position="21"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12873.t1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49378" checksum="C487496548617FBE" modified="2023-02-22" version="1">MRYSSTFIIILVVVFDVGIGGLPQHPQGLPQHPKRQNRHARSVDGVPGADDHKLKQQHNQPQGLPQHPQELSQHPQGLPQHPQGLLQHPQGLLQHPQGLLQHPQGLSQHPEGQNRHARSVDGVPGADDHKLKQQHNQPQGLPQHPQELSQHPQGLPQHPQGLPQHPQGLLQHPQGLPQHPEGQNRHARSVDGVPGADDRKLKQQHNQPQGLLQHPQELSQHPEEQHRHARSVVGVPGADDHKLKQQHNQPQGLPQHPQELSQHPQGLPQHPQGLPQHPQGLLQHPQGLLQHPQGLLQHPQGLSQHPEGQNRHARSVDGVPGADDHKLKQQHNQPQGLPQHPQELSQHPQGLLQHPQGLPQHPQGLPQHPQGLRQHPEGQNRHARSVDGVPGADDHRLKQQHNQTVPQGLLQHPQGLPQHPEEQHRHARSVVGEESSLQQPPSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0F8</accession>
    <name>A0A914H0F8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0F8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12799.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12799.t1"/>
        <property type="gene ID" value="Gr19_v10_g12799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12799.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14059" checksum="C95EF7BC822D724D" modified="2023-02-22" version="1">MNAKSELRHLQQCRRAQLTGQKNCPFHCVHQQFLPPNKSHDIPLAIFRQSRKLISEIRERFSNLESKRIYAVAHYLDPRFKDQFWRNEMPPSPKKKCISLRPARINCCSKNANKGLKSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H115</accession>
    <name>A0A914H115_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H115"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1226.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1226.t1"/>
        <property type="gene ID" value="Gr19_v10_g1226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="10">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1226.t1"/>
        </source>
    </evidence>
    <sequence length="566" mass="62890" checksum="00D617213EA2BE62" modified="2023-02-22" version="1">MSSIVRQSKFRHVYCKQVKQEQCIQDVRITEVSWDSQFCAVNAKFIAVVNKGAGGPFLVIPINKSGRIDKEMPFVDAHRAACLEVHWSPFNDHVIASCSEDTTAKVWLIPEKGLLHTIHEPVVELNGHQKRVNTLAWHPTASNILITAGGENKLLLWNVGTGEALLEVAGHPDQIWSVSFNYDGSKFVTTCKDKMIRIMDSHTGAVINSGIGHEGVKPQRAIFTKDGHVFSTGFTKRSERLYALRQTDNLSEPIMQDELDTSNSVLFPLYDEDSGLCYLMGKGDCAIRYYEINSDPPYVHYINTHTTSEPQRGFAFMPKRGMNSSENEINRIYKVTTKGVIDILQFYVPRKSDLWQADLYPDTRSLAPALTAEEFIGGKNAPPNLVPVNPEAAKAGPKVQVAKKANILAQMPTQQEHPPEPPMQRPPPQLQRAPVRHDEDTGIVRTSRREPSPPEQAPPKQQVQLRSREARDDPGAQTAGQRRAAAELDRIRREQNRGGAGEADGNGTATTPNASRRQSNSSAVAGSGSVEEELAKIKVVLRQHERRIRLLEDQMADTTMANAYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1Z6</accession>
    <name>A0A914H1Z6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1Z6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12492.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12492.t1"/>
        <property type="gene ID" value="Gr19_v10_g12492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13193">
        <property type="entry name" value="FERM_C_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17098">
        <property type="entry name" value="FERM_F1_FARP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000040">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000005">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041788">
        <property type="entry name" value="FARP1/FARP2/FRMD7_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF5">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="31"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12492.t1"/>
        </source>
    </evidence>
    <sequence length="1279" mass="139254" checksum="B6ABC66EEC552BF7" modified="2023-02-22" version="1">MQKPVTSKIPHGVGCPPPPGMDPRKGKGKLMCIKVRMLDDSVGVFHLGHKAAGQALFDEVCRYLNLLESDYFGLEFIDSFGNRCWLDKDKSILRQILVAQSDARFLFIVKFYTPNPAELEEEYTRYLFALQIRRDLSRGELLCTNENTAALLVALIVQSECGDFSPLDYSDANVYLAGTHFVPQQTHAFAQAVMEQHRRLIGMEPAEADFTLLETARRCDFYGLRLHPARDIEGTEVALAVAHMGIKVFHQMNCVTTFSWAKVRKFSFKRKRLMIKVHPDSFQFYKETIEFSFENRDDCKNFWKKCVEHHSFFRCAEPVVVAGAKGGEDGGRKQYQQQQQHHHHLFSRGSNFQYRGRTQKQLIDYVREHRKRREPFQRPLRRGNAMFTGGGTNFGTNSLGRAAQFLVSDRMVKDSEAMGNGQHRNGRVEEANFACTFPSLCAQHQQQQKLQNGGKGRPKSALLSDEKRNQKSSKQQQQQPQLSMQNSYHAGMAQRQENGIATEAHQNSVAAAETMALFHQHMDPMCMSMPNVLLTTDSPIGPAAMAKLSPPSAANASASFLHSAHKSVSGENFHYAAELREDNLSEDLFILGSYRVGGRGAFQRLAPQQKDGAASSTASSQSDIVSAVHSPVDPRVYQTTFTTKRVGNVIMKRVMNNDITPTPTAVGADVKPSAHRRPPLTSRSAVDAGDPGDESDSLASSSAAFSDYSLAATAPPSACYPPTTTVSMAPSFARSTATGRIRCTPPPAVATQQQQSIPVTIANQVLLPVHLRNEVPVPIDAPPPVNIVSRPGQQQQPAMSTKTTIIRPVLLPSPATTTNSLDKGRTALSSSSTIASAGSSCIIVKRRPSSSTASSASTPTQSTTAQRRPIVVAKASPSPPPPILHINGGLEAAKTKQNRQKEDTTNRESDGNSSCDGGRGDGPMPGCVIQRQDLVITAGGIALRGAKSGESVVEKPKVLPKPDLGTLMGLIGQHKQSETNRNLVDPLESILKDVRSMNEALDGLESPTGSGGTPRSQSSQKVGAVAATAADEQQQAVSGAVSSRRRPPDAISVESDEWPSVRTLHLFNNGNNRVPYTLTVRDLSGGQTTTIGDGEEKQREGAALASSAFSTGGCGRSRNATTPEGPLAMIGGAALRHKSLELVQRKRLPAQGAFSSQDHSITATSPEAGNVFEYVVSQRRRSASSDRLIVAHSTQCQQNRRVSNRRQTQPVEMVGKWTTGRGEDIQISADLTEEKDEKIVGILPSEVLGIPTQNSEDSASSASTQQQQRLPQQLLETDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H283</accession>
    <name>A0A914H283_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914H283"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1321.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1321.t1"/>
        <property type="gene ID" value="Gr19_v10_g1321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="10">
        <location>
            <begin position="44"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="223"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1321.t1"/>
        </source>
    </evidence>
    <sequence length="444" mass="48234" checksum="077009AAD5033F42" modified="2023-02-22" version="1">MGVVAAFSPNSAMNFAIRKRFASCALPPSEGGDFEYAFEMTSSTLRCGNGVTGEIGFDLQNIGSKNALIMTDKNVANTRAFKEVAASLGRLNLTYQIFDEVKCEPSQQSMQRAIDFARAKSYDCFVAVGGGSVIDTAKVAALYASNRESDFLDFVQKPFGKALIPKQPMLPLIAIPTTAGTGVSIIDIPEKQCKTGIRLRCIKPLLAIIDPLNVKSMPRNVAIYSGFDVLCHALESYTAKPYTMRIPRPPRPDVRPVYQGSNPQYFRRSIFDPEDEEARTQMLMASSFAGMGFGNAGVHLCHGLSYPISSQGKSYFDPDYSKDHALIPHGLSVVCTAPADFLFTTVADPKRHLEASQLLGSGLSVSSASTDMIANTLADQLRAFMSDFGCPNGLAKMGFDRHDTDTLASAALNSFRSNPISPREIDFDSIAKHLRTVPECVLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2T0</accession>
    <name>A0A914H2T0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2T0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13621.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13621.t1"/>
        <property type="gene ID" value="Gr19_v10_g13621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13621.t1"/>
        </source>
    </evidence>
    <sequence length="472" mass="51791" checksum="B5AEBF7184B3B749" modified="2023-02-22" version="1">MASPGDQSLKESLECPVCKDLFSEPKQLECGHTYCLDCVNGLDKVPNVVHRIVGEDFFDTLGVGPVSTLVQSVQNNVQCPQCRKMCLIPDGGLNTNYAIKDMVEKFHQTVQLEDDEYFDGITNAAAREAGTQTKKDEQQQQQLMMCHSCAKRVPGSELFMCKDCNGPPANKQIICALCIVHSHKLHTVVPLVNLASAGDRELAVLRIEEILYQAQRVGDETRSLQTDVTRQFEAVQEKLLAKLDCFRVFQSECRDSEQSALKEDVEAKVGEAIHQCEQLNEHFLRLNELKMEFERQLQRWQDDFGASLPPVPSSAPPLPPPPQQPSLYYLRQYGSIFGPDQQPTATSSTASSGARPMHHFVFSSGGGTGDNDDGPNLVGSSNSSRPRSKKVPPILVAQRRRSRLRGNLGAGAGGGGAGGASGSAAFSSGNNNNSDSNYPPASARTVAANLEQSLRQRQRDDFKRFDENYGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3E1</accession>
    <name>A0A914H3E1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3E1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13629.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13629.t1"/>
        <property type="gene ID" value="Gr19_v10_g13629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="32"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13629.t1"/>
        </source>
    </evidence>
    <sequence length="564" mass="63939" checksum="C9D274DB7B054456" modified="2023-02-22" version="1">MEQLKELGANNAKDAIEKGELIAKMEQYQNKQQQNIDALTEAQKGNALTPQNRWDSAACHKDLTLIGRRLTVQFTEKKWGYRNVFAKESIPKNPFGIFYFEVTIVEKRDNDSNIHIGLATKQMPLDKCLGFYKGTYAYGSWGTFMGHAIESRAPGVGTPPAFGVGDVIRCGVNLATRQIIYTKNGQRLATAGLFVNSAAELFPCVSLRAGTKIKANFGSSNTADEIFICDDIWYGVFALLGPFDIGLKMALISDRLDALMDVHFKSRKWSLGRLQIRRAIGGNGAQIVNLSDERQPIPQGPIPNSVIGFEVVEISYVDQTVIEFLQRIRRLFDSSGTNVNIEINYGHQNRSWQIIWHRIWPLINDNICGFSVSPPDLERLRQFSPTVFCDCPKLRVISFDGIPKFPADDSAGASSEQALAKWLHTPRGDGLPKMLCCGVYSEEMEALKRSFVNASEPVNFIIRFWSEYDDYTASFELKNTLTGERLTLAWRRGKKWLELLLVRCPIKQKKEEEDKWAKWEKETIEFDWDNQWNRISIRFNDSGDIGDGMFDENDDPSEPRPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H546</accession>
    <name>A0A914H546_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H546"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14247.t4">
        <property type="protein sequence ID" value="Gr19_v10_g14247.t4"/>
        <property type="gene ID" value="Gr19_v10_g14247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14690">
        <property type="entry name" value="bZIP_CREB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000003">
        <property type="entry name" value="cAMP-responsive element modulator isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003102">
        <property type="entry name" value="CREB1-like_pKID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001630">
        <property type="entry name" value="Leuzip_CREB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879:SF3">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02173">
        <property type="entry name" value="pKID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50953">
        <property type="entry name" value="KID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="KID" evidence="9">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="303"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14247.t4"/>
        </source>
    </evidence>
    <sequence length="365" mass="40488" checksum="A8AED84A68293B53" modified="2023-02-22" version="1">MNSSMPANESLESTDGDESNSELRDPHSALGVEEVVNEEEARRRREQLNRRPSYRMILKDLETVGDKQLKKEMLEDGNTPNTYNHNHERNGRNTVHQLGSPDESAPFVNNNNNNIGGGGGTAAATNQQQLTQHISPPTQQNLAALGQLNLIGNPAATAQQQQIRLMSAVTEMPSQPQPQQLPSTNSVSQQQQQPQPLLTAVNNLEMLGLKAPETLGAFGQNDWQNNLLSSYSRAPQQQQAPPQQQQQAPLMQQNNAGGPVGSVPSPLSMQQQQQQQHVTPPHGLGTRQGSASLTSLSDNDDNSRKRQVRLLKNREAAKECRRKKKEYVKCLENRVAVLENQNKALIEELKTLKELYCRKEKGDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H661</accession>
    <name>A0A914H661_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H661"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14549.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14549.t1"/>
        <property type="gene ID" value="Gr19_v10_g14549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF35">
        <property type="entry name" value="NEUROGLIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038092773" evidence="4">
        <location>
            <begin position="17"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="72"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14549.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35299" checksum="1A7D16D52F8B72CF" modified="2023-02-22" version="1">MFIFYLTLLTTDLVHSTPTHFDSGGQIDWAAIPTPPRFVHAPNDGIAYFVMDHRKVPNGARLRHSAERRQHPTTAREEAGDGEQRQVNKPRTLRCAAVGVPKPEYKWLKDNATLPLEVYTSRILSNPDNGSLTFVQFEDTDEGDYQCLALNGNGTAYSEKMRLQQAWIRAFPVGKGPEIVTVPMGRPYTRDCVPPESSPMASTFWLFQSPGNERQIQGINSSHISTNDRGTIFFHHVKETDFKASTLYTCAAYNHELKEYKFSDNAFNFNITRRHDRNLHTVPPEQQWVNQSSPIALLGHVHKLHCFFSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6E8</accession>
    <name>A0A914H6E8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H6E8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14604.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14604.t1"/>
        <property type="gene ID" value="Gr19_v10_g14604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="166"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="314"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14604.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="45355" checksum="89CAB6DFB5A70273" modified="2023-02-22" version="1">MLGGGGFVSARSADKSLNKHKNKAPERNAKMPKMDKPLMNVEEAGSSKMAIAEGSRREKEKRAFIELSALLPLTPPIRDQLDKTGTLRVSISFLKLQRLFGTLAAVSNASNLKKSVICGPTTSKVDDAFEQTAQNAAGFYGLGMSKICFDSASGKPELMHQFAYNLFQAMDGFVIVLDCEGKVVYTSETVAVHLGLAQVELAGIALADFLHPDDAPLLRDLLALHLPARAFRVLQPELRFTLRFRCTPGRRAMMGCNGMGMQPGFKPIHFMGTLHADDDGRFMGYGQPSVAYGLNELRLCTSMFMFRATPALQLIFVDNCFTELTKFMPDSLLNQSLYSFIHPADVNQLCEVQQTALRGGQALSAFFRLLNAEGGWHWVQCRLCTTITSRLPSLTQIVVVSEQMASGQSVRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H897</accession>
    <name>A0A914H897_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H897"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15135.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15135.t1"/>
        <property type="gene ID" value="Gr19_v10_g15135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15135.t1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36307" checksum="E5B1621E4723CB2B" modified="2023-02-22" version="1">MEMETFCLCCAGTEAGGIAYLIEKRLKQVISPILLDEMVSWVLMKEMGPLKKAANRTKKWAEILIKQYLHNGQIPNFHFERFSRSYHMNIGTCFRLRPKFGLQWRHFCCSSLSLAAAHDDTLKHAHHQQKQQQGNVKMKTDGGGGAVAGPERTYLEEMLIQKEEEPKTTGQKVKRAAETTFYISFGLLSCAALGIMTFLVFREFFAFSSPQGVYRNSAKRVKADAQCREMFGKRILTFGEESGRGRRRNLLHRKYVKDGQERLSIMFHVKGDVQVGKVYAEIVKGEDGGWDYHFILAETDGFPKRTAFLVDNRKTTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8A0</accession>
    <name>A0A914H8A0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8A0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14730.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14730.t2"/>
        <property type="gene ID" value="Gr19_v10_g14730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14730.t2"/>
        </source>
    </evidence>
    <sequence length="120" mass="13413" checksum="DBB3A0E9A1B41EA2" modified="2023-02-22" version="1">MAAYPGDPLVDALQHLLRGNTRLHTIIANVSSEYYLVHLRNLVAGAFRVSRSFGLNLADPPYPPHTHDMFFTQLERMCNHFSENNNIPSEISAVGTLLFDLARKAEHYVTAEHYAPAAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H987</accession>
    <name>A0A914H987_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H987"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15383.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15383.t1"/>
        <property type="gene ID" value="Gr19_v10_g15383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15383.t1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53948" checksum="B5DDB0CF290CB97A" modified="2023-02-22" version="1">MEWTLSFWPNESAAPFFAGRLIAQHSTLFTFAQTAKAHRPISESRVEIFIQSSYPKTNQLSTPQATKMNKWAATSLVLLIAILCGTIHGAVLREQQQPLDAVHQQAPDHINGEQARKKRQDRGRFPDDPNDPATTTPSTTKPPRPVDRRNGTDTKNTSDSSMTSTTRMPPASNETKGNETGLYEPKDNPDIKRNYTANLIYWNDVTGMCYRKANASEKADKPINGTDIRVINSAEMTDATAKTETPSGNNTIFNAWSYCAKVQFYGNLGLDDAKTYFGKEKATQKKEFSDMRDFENGGFMQDMVLLLIDGRIECKSAKEDMDVHLAIVQDLEAGKLSELCGEEKMHEFGNTTVTLEKGTSYFVFGVVLRERLCPHNKVPGTPPNNTGDLVIEELKYKYENVKLTVTIKLRPIDVFEMDRLDRVLQLRDLTLDLSMLVDDDVMLEKGAEMKDSISGIYYLPSIGAGTDKNATNPMVKKMLAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9H1</accession>
    <name>A0A914H9H1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H9H1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15038.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15038.t1"/>
        <property type="gene ID" value="Gr19_v10_g15038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037734089" evidence="5">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15038.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11584" checksum="0962EE609448AD25" modified="2023-02-22" version="1">MSFTNTITFLLLAMVVLLSLLEQHAHAGKGAERIVVMYKGKSYDVTEFKNKHPGGPKVLEAVNGKDVEEYLLGKTGVKLPERLVQHKHAQVVFDKVLPSFLIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAJ2</accession>
    <name>A0A914HAJ2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 21</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71739"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71755"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:72701"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71747"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71751"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71759"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71743"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAJ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15735.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15735.t1"/>
        <property type="gene ID" value="Gr19_v10_g15735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="100"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="207"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15735.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33246" checksum="E68FA685E5213F80" modified="2023-02-22" version="1">MERLKEGGRQFVAGGTAGMVEVCLMHPLDLMKTRLQVGGSRYAGLADCFRQTLRKEGVSGFYKGILPPIIAETPKRATKFFTFEQYKRALEPLAHQCHCPAWACLSLAGLLSGLTEAIVICPFEVVKVRLQTELNVSLAEQRSSAAVAREITRANGIGTSGLYRGLGATLWRHGVWNMFYFGLYHNLRTFMTTLKTNREGNQSPQGISVPLRLFLGFLAGSVASVANIPFDVAKSRIQGPQPESGRVYHTTWQTVRLVYRREGFTALYRGLVPKVMRLGPGGGIMLVVFETVYEFLAKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBP3</accession>
    <name>A0A914HBP3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15870.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15870.t1"/>
        <property type="gene ID" value="Gr19_v10_g15870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15870.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26462" checksum="5380B63EFE72E74D" modified="2023-02-22" version="1">MVLSSALDDLQRKARLLENEIDAQLISLNKFNASNGLPYNAHQTKAQSKRAVFDSLTNDIENKLSKLGEINDAMRESFENDVAEFSRTSAQHIVRRHRDILRDYNTEFIRTCSNIGSQLQREELMEVETESSVNNRCKPTDYLLREHESISSCDRLLNEQISIAMSVKENLYTQSTGLSSLGKRLHHLTKKYPAINHLMNKIRMKKRKDTLIVAAVISTCLMLMFLYVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBV1</accession>
    <name>A0A914HBV1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBV1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15913.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15913.t1"/>
        <property type="gene ID" value="Gr19_v10_g15913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15913.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9379" checksum="58E624F952665988" modified="2023-02-22" version="1">MENIFKFKLLNFYSLRTVANRGNTSNFGIGTATIFRGVIPSGGRPTKIIAKHRIGGLKPNPSTDVRICAELNGPNPSPPSACLNRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBY3</accession>
    <name>A0A914HBY3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15661.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15661.t1"/>
        <property type="gene ID" value="Gr19_v10_g15661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053287">
        <property type="entry name" value="PP2C-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586:SF0">
        <property type="entry name" value="PP2C-LIKE DOMAIN-CONTAINING PROTEIN CG9801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586">
        <property type="entry name" value="TIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="223"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15661.t1"/>
        </source>
    </evidence>
    <sequence length="977" mass="106969" checksum="A0241FE4B53CF8C7" modified="2023-02-22" version="1">MSAFLRRRMRGLLRTTPNSTDTVSSIGGSDEQQQQQQQQQFRCDEVEEELMLVMKLNGQQQNGRAGRSSESAAVYERILNGRNGRRVESVPEVYSGKTGLDLPSIHLDKFTSEVKACHTGPDGGLTKVQPIRKRAIAAMANLDDEEFSLSSMDEDEATETNSNDRCQNGKRRAKTSLSRTQTDSFEILDIINLSRDGEKPVVSSVPRSSLARYDWNSWDEEKAYGLSTSLYEKHPVTALSAGHPIADVFGIVSRENNAIIALADGVNWGEGARLAARCAIRGAIDHLNAAIERGDTLNTTNDVFHCLLGSFHAAHALILQEGGALTTLCVALVAPVRDSASSVLCACNVGDSLCFVFNDEHGVREVTLASHDIGQMRDMRDAGGALGPVDGRNPQLQNLTCSMTFVRDGDLVFITSDGISDNFDPVVGKFCVIKRSRVDSSEKENVADGVEAAALPPKPAQFFHKTKSAPSANGLLHFSPFPPQHNQLRSMIKRPAAILPSVDAVERHELMLLRMCDVISNGEAQIRPSEESHRHAHRRAAARPCCPGTTTTTTNNENSRRPQSLSAAKRRTLEDPELYRTRTHSKTEERLRRKVIRDMIMEMPGKLDHASVVAYQVGKWPQPAESPTLRRRTTEWDGGMELDGVFVERRHAGGAGRFDENDANGAIVDAVDHPQSCRVDDPSPASIWPTAAAICPAEENGGGDGRMLRQHNDTTQQRPVVEQTWQKTTLNAEQMGGRRRRHGRDSEARHTLGVDVSWLKRLVTSKHEQKQQQQLSGTNGNYSGEIVGNEQTHPPTSNGKCQKGTTISSAPVGVKKYREGGGSNFSLRKLRVFVRHQQQPVPSIEQQHQPPRSRQPSPREDGEGMQRQQPPSDQIVRHGNGFLLSDGIKSAAPSTSIICVQQSSAAAADCCCVDRAVFDDDGNVPQPPTVPRMGLGQLLGPVAADERQQNCCAAKIVAPMAANDDDEDEVVLKGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCB3</accession>
    <name>A0A914HCB3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor BTF3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1579.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1579.t2"/>
        <property type="gene ID" value="Gr19_v10_g1579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="4">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1579.t2"/>
        </source>
    </evidence>
    <sequence length="170" mass="19107" checksum="C095FD7EF499C0E3" modified="2023-02-22" version="1">MEGTIFSITFECDKNLQHWFFNFFDNECRENKETATKRRTCPHWWKGYCKKEEESVTNIPGIEEVNMIKDDGTVIHFNNPKVQASVPANTFSITGTAENKQITDMLPGILNQLGAESLTHLKKLANNTTQFKPSAEDDDVPELIGDFEEASKNETKTTESGADANLSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCB4</accession>
    <name>A0A914HCB4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCB4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16201.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16201.t1"/>
        <property type="gene ID" value="Gr19_v10_g16201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF122">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="848"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="893"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="313"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16201.t1"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111896" checksum="B1D382E11307ED35" modified="2023-02-22" version="1">MHGAFCPAKAEEHRPVDAQEDERAETLFVRMLNRLFHACGKAIAARPWLFIVFSLVLTALCTVKLPLTPMSNDVADFTPTGARARRELEAYEAFFSNKGDPIALYVLVYSKQSGKNMLGVRELEEVVRLLNIVSERFVMFNSESGRNESFNEFCDNFCTINEPIRHFHSGLLLERNFGNSSLEHIDLGYPITTVLGRQLHMDPHFFGVKVAVPDSNGTVRNVSVNQLRTANGQSVFDAPNSQQPNNIREIALVGLQFRAERSHGISKEAMSTWERNVRQFVRSEFQSDVVKALVLSETILTDEVVRAGLTLLPFLLIGFSIMVVFSSCTMSISAFYVRQMGAQKILLAVVACSCPFMACGTALGGMFWLGFRFGSLLCVTPFLVLAIGVDDAYLMLNAWQRLRVRLEERLEQEGRSVSVQQIVQRLMADVMVDTGASITITTLTNVLAFAIGAFTPTPEIQLFSIGNASAIVMVYIYQWTVFGSAMAIFGRWEFRTHPAAIAETPSIDTPPSPDSSIGGTSAIEDNASADSGIVKGSFSMSTVSGEGSGAERRRGGICQMFWRFVRATCSKLLHLYCRVLTNNACAIGVMVLLAGYMYTSIYGLLNIRAELRPEQLFLRSSDIIVLLRLRNEYIMPFYAVCMVFVNKPGNFTDPIQRQKLHSLVSDFERLPSSVGRFSTKFWLRDYEQFVEQDPEDATPPLNDLAAFEGIPLTERKRNELSEFLQWPEFQFWNGFLSRFFFTTASYGAELRDWSQREVLLGQWRRVADSYPELEVSVYEDDAKFLDLIPTMIPQTIQSSACTLLCMFVVCLLFMTNPGALLVSNFAIFSTCIGVFGIQSLLGTGLDPIFMSAAIMSIGFSVDIPAHIAYHFYKTKVDEKGRTLSVEQRLSDCLAAIGFPVLEAGLSTLICTSSLFFVDLHMARVFASTMTLVVAIGLLHGLLVIPVMFSLFSTVWPTVSGSVVWPTVVSNKLRARARCCAARVPSGHRWSKWERIPYLPLPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCI5</accession>
    <name>A0A914HCI5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCI5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16256.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16256.t2"/>
        <property type="gene ID" value="Gr19_v10_g16256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="398"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16256.t2"/>
        </source>
    </evidence>
    <sequence length="602" mass="69207" checksum="D12FB650E9CEE077" modified="2023-02-22" version="1">MSFFLLYLWPSFAQPIAELADELARQRTDSPSPTESGFDLVSTDGGQNDEDGTGFGHAHVMATLQHEFRDNIGSIEPSVIWLQQGQVKCVSVEHFSLLRAKIEELERKQKADQKEHRSKIDEMAKAKVAAELENQQLVENHKALNRKMEQYQNKQQQSQEENEKLLNAHKNLMEEMKLKQQQHQKESNDKIGWLNEDQQKLSVSIDHFLLMQSDQKALLERLNGLEQKQAAYAEQQKTDQKALRATIDQQFNEREEKLNNFLGHKQQQQTIGVLTERQKGIDPFRIMGFIALFILFIFSLNFVQAKVITELEEQKLSNANKFAELEKQNALQEKVVKMEKYQKDQQLNSAKMEKYQKEQQLNIANMEKYQKEQQQKMEKYQKEQQQKMEKYQKEQQPTIDDLQKTVAAMRKIGLTVQNRWDSAACHQGLTLSETDRLIVQITGKNNWAWHSVFAERPIPKNELGIFYYEVTILEKANDVHIGLASNQMPLDVWVGYYKGTYGYESNGRFWGHAVKGCHHSGKGRPFIKGKPAFEEGDVIGCGVNLATRQIIYTKNGQRLGTAGLFVDSSADLFPCVSLRDPGTKIEANFGPNFKFNITADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCI8</accession>
    <name>A0A914HCI8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15358.t3">
        <property type="protein sequence ID" value="Gr19_v10_g15358.t3"/>
        <property type="gene ID" value="Gr19_v10_g15358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15358.t3"/>
        </source>
    </evidence>
    <sequence length="280" mass="31683" checksum="C60144E1F14C0119" modified="2023-02-22" version="1">MAECLECKAKKEGKYQFKLSDGSISSLIGHLRSEKHKNSEYKTKFDEMTKNLEKSVVKCRKAGGIENFVVRSSGNMTRLDKVIVNLICCANLPFNLVNNPHFRTLCKPWSEQLKDESHYRKLLPIAYAAVKEKMKAELEKCNSISCTSDIWTEGITDKWTRVVYTLAIQPFPGSHTGLRVAETLSTIAFEEMDNNEKILPFFRANCAAHLLDRSVKNSFGSKQGAISELFANCRRIVSRVKHSIKALDELKEVQELEGNGCSLELFFDNDQTFVGTEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCR4</accession>
    <name>A0A914HCR4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCR4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16157.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16157.t1"/>
        <property type="gene ID" value="Gr19_v10_g16157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16157.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27737" checksum="A3CF6334B8C562FA" modified="2023-02-22" version="1">MRRCFDALASDRQRQQLMMNAAAAAAPNGLPNRRTQNPTVVNVALRMPTKMNVQICELNKVAEMFELVLDPVQLDKTPKCCQKRAPQGRVGDWKRFSVTVVQVGDKLGLTRNKWPAQKTRAQMRALICAQIAGKVAEERAFETSLYHGVDQQNWLRTARALVRASRADRELAPELQEAHLAAAMDTVIAQAHDRVRRILMANEKKLRQMAQLLFRKSSFNADEFRREDGIDHTRQLWELLACY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCX6</accession>
    <name>A0A914HCX6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">TATA sequence-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TATA-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">TATA-box factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Transcription initiation factor TFIID TBP subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCX6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15887.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15887.t1"/>
        <property type="gene ID" value="Gr19_v10_g15887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="17">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15887.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="48618" checksum="840F522111D9EF1C" modified="2023-02-22" version="1">MERVEKFITRKCAPEKQTRLIYAARFSMVILTCAIAELIPHLAVFISLVGSIACTSLALVFPPMIELLVCYAQNKLTFNVYLRNVIIFFFALIGFVTGTYSALSQIFQHSLLGGQTPMHGVPSMGAAGGPASVNPSSIQANYQNVFGIGPSSLNIAGAQSIHSNNGPASIFNSHNEPSSVLNAYSSDFKGPTSVTNLAGVPASASYGGDQQPPESVSNLAVPMTPLNSAESVHAHRTPKQHHQPHSAAAEPPASNIPTFVPATPFSNASVEIPSPTLQNIVSTVNLGVQLDLKQIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEETSRLAARKYARIVQKIGFNAKFTEFKVQNMVGSCDVKFPIQLEGLCITHAQFSTYEPELFPGLIYRMVKPRVVLLIFVSGKVVITGAKFKKDIDEAFSQIYPILKGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD37</accession>
    <name>A0A914HD37_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD37"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15513.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15513.t1"/>
        <property type="gene ID" value="Gr19_v10_g15513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15847">
        <property type="entry name" value="SNARE_syntaxin7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF411">
        <property type="entry name" value="LD23667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15513.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26062" checksum="B51CB1AFB6AFE42A" modified="2023-02-22" version="1">MELENKGAEAVVQKISLNIQQLSQFVQNLNQLIEKIGSAEDNDRTRNATNDLLHKSNELSHTTNQMLKKLLADSNANRAVRVQSERLMNDFMGVLNRLQASKRKAAAREKTQIRSVTMRQLQQQHRMNLDEIRERQQALTALEQDIGDINQIFKDLAHMVHDQGEMVDSIEANIEHASIHVQQAHTNVTQAVHYQTKARQKKLMISAFCFIVFLVLFLVLYLWLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDJ9</accession>
    <name>A0A914HDJ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDJ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16139.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16139.t1"/>
        <property type="gene ID" value="Gr19_v10_g16139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16139.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11799" checksum="8C41B29809A721AA" modified="2023-02-22" version="1">MSDLYGFINNFSKRVMRRGRDKAAEPGASAVANESDASGADPKPKQHKAKGGSRCCLWITLGIILLVIVLALGGLVLTVALTPDTFAKTPVLDKLAELFKKKDAEEDETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDY2</accession>
    <name>A0A914HDY2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrator complex subunit 5 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDY2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16467.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16467.t1"/>
        <property type="gene ID" value="Gr19_v10_g16467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040316">
        <property type="entry name" value="INTS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029445">
        <property type="entry name" value="INTS5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14837">
        <property type="entry name" value="INTS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 5 N-terminal" evidence="1">
        <location>
            <begin position="46"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16467.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="44200" checksum="196130A89909A49D" modified="2023-02-22" version="1">MMEKSSAFPPTNPRLAQVQACFANFFSIANLGDTNSAYRGKPIWTNYQTDDICQPVMKLLIEVPASRDAVLYFISNLIHENVHLHLSEQERKDASKSVDYSSLQRAVLRLLTNLNTFRVEYSDKKMSFSISLLKMLFELFSELFRKNCQRPFFTHQPPPPALFLSEFQQIQCVSELFALLDSTFASLMQIRPESAVFAFVSAHKSFFANFDWVAIHIAETFPSIVVHLVRVGAEEFCAHCNEMLNPAVRLNAAHVVQLQDEYSTRLRLFTEVFLYMERKRKLELRACFMSIKFLRTGDNWRELLFLIKLSLFSPTVTLPFMDELLPHIIQHPFLADRLHELAANPALSIAVSPTNFLQNFLRKMVENASTEHVFDLAKIVSTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFI2</accession>
    <name>A0A914HFI2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase M12B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFI2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1650.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1650.t1"/>
        <property type="gene ID" value="Gr19_v10_g1650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037058162" evidence="10">
        <location>
            <begin position="21"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="242"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1650.t1"/>
        </source>
    </evidence>
    <sequence length="609" mass="68032" checksum="82FB738817A7C06D" modified="2023-02-22" version="1">MCYFYLLPIVVLIPFAEVLSESVQLVEMVDLDNIVFTKSVRFVDNGTLAEDVQVLDKLYSKETAQRKEKREQHPKRGTANDRRTPQRQRLEARILMVGDHSLHETFLKLYREDEYAAYTALSRYLLGVFTQLETIFGRLSFLSADSSLPHQILFQLAGPPMVIVRPEDCPLRGPMLIALEQNAVNASTASETAAVGNVFNPDNATTATIRNEQLSENDDGLEKALAAGIEGWNRMDGLRAVQWTHRWVEHSEGLLPEHDHVMVLTRMDLISQRNDSATQGMAYVRAICRGADSVSVGREVIRFGGVEAGTATVAAHELSHSLGAFHDGSDANINCSSRQNFLMAPISASHTFSAEFGDTFPNAFVLSDCSKRQIEQFLSSAESNCLWRKSTLVKRPSTSADLPKSPNPNSVLLMKSGPGQLNSDLMTSVDDAQRTANESPAGVGEGEWWSTMVSRGHGKPGEQFDPGKQCQIVFGSQYGICRRRDFMLLNSDPCRRLWCKNRQQRRWAPCETKGFLPMMDGTRCGEGKWCVRGVCTIKAKLSKRSEHQQLNDDSFGDELSDDGEYFGCRDLNPSFCSSFGSELLRSFCHVLNFSRICCASCRPIQRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGX8</accession>
    <name>A0A914HGX8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGX8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17073.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17073.t1"/>
        <property type="gene ID" value="Gr19_v10_g17073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17073.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="24672" checksum="799C522E14BBA2F3" modified="2023-02-22" version="1">MALTFGREGASLTIQGPSMDRLTAVKDCLVRSGVDERRILAVSGPTLEENTAMELVERSLQRFGKIDALILSVDLISDSIEHAAVDQLFGATMRWLVYLSSLVVKPLARTDGSIVVISGNLPKTAMAAQWHTISRSALKGWVSNSAQMFGPKGIRVNGINVGSIRADFRSRQANIEEEQNFCSPASAANALRRTGTLEEIGHVALFLASAARAGFITGQIISVDGGMSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHR8</accession>
    <name>A0A914HHR8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHR8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16744.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16744.t1"/>
        <property type="gene ID" value="Gr19_v10_g16744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="40"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16744.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17988" checksum="5926DB89BF9DBBBE" modified="2023-02-22" version="1">MSSLLPFDPFYRRALWPSVGHSFFAPLEQMERELDRFFDGIQPQLRDHVAQLSMSDSGELSYKVDVSGFRPEEVNVELKGNEIVVEGEHREQNQGESVHRQFCRRVLIPEGIQKESIKCELDGGRLCITGMKTTGDGKRSIPIEVKKAIEQKQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI72</accession>
    <name>A0A914HI72_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HI72"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17154.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17154.t1"/>
        <property type="gene ID" value="Gr19_v10_g17154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000924">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="8">
        <location>
            <begin position="39"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17154.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43900" checksum="B14AA97BA368EA2A" modified="2023-02-22" version="1">MLSGLLKRLEEDCVESTKIAMDTEDAKEMEEYRARKVALITGISGQDGSYLAEFLLSKGYQVHGVIRRSSSFNTARIEHLYSNPFTHSVGSSFNLHYGDMTDSSCLIKLISTIRPTELYHLAAQSHVKVSFDLPEYTAEVDAVGTLRLLDAIHACGLTRKVRFYMASTSELFGKVQEVPQRETTPFYPRSPYAVAKLYSYWIVVNYREAYRMFTCNGILFNHESPRRGETFVTRKITRGVAKISLGQQELLELGNLNALRDWGHAREYVEAMWMILQQESPDDFVIATGKNYTVRHFIELSFKEIGKTIVWEGEGVDEVGREKDTGTLRVRVNPKFYRPTEVELLVGDPSKAKKMLGWEPKIKIEELVREMVASDIELMKKNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIL7</accession>
    <name>A0A914HIL7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIL7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g180.t2">
        <property type="protein sequence ID" value="Gr19_v10_g180.t2"/>
        <property type="gene ID" value="Gr19_v10_g180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g180.t2"/>
        </source>
    </evidence>
    <sequence length="391" mass="42903" checksum="F9E616E1457EE2C0" modified="2023-02-22" version="1">MMKNDEEWNNVWKQLKTKLHSTMVAFGSGSVSLPKLMDTFRNDWSTELTSYAVRLGYGSNDGAVYKMLLTMPDEIESGFISATATLAFKVVPKAETNDNLSKIDKSNQYQIDQRIARAQRRTSNGHHNFNNTFHAQPSMMPSTRPPFALSGLMQNAPRLSRPPPEQRKKTRAQRRSSAGHHNFNNTFHAQPSMMPSIPPSPLALSAPMPSPSEWPRPALEQQIQQIMRASKHRASNGNHHRSLETIVVDVTSSNTRIVNVTSSDETLVKVTSSDGTLAKVTSSDGTMAKVTSSDETLVKVTSSDGTLAKVTSSDGTLAKVTSSLVDIGTDSDFHKPATVGGEGHSECHKVSSSSSNSWLHSLLCFPPYLSSLRQQAKYEQINDNNRGTLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIL8</accession>
    <name>A0A914HIL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16978.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16978.t1"/>
        <property type="gene ID" value="Gr19_v10_g16978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16978.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16878" checksum="1A6E386C9FC8BE3D" modified="2023-02-22" version="1">MADDLFVKRAETFIVEHEGFYYEPKTFVRHKEESYFETSLLRNNGSICVGFVPRNENSGVVGWTTSSYGVEGSGELLREGELVLKIPPFSAGDTIACSWDKKSGLVNFFLNRERLGEQLVAPVDARMFPAWGGAEQKGFTPIVVGHCLAVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJI2</accession>
    <name>A0A914HJI2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
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            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJI2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17758.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17758.t1"/>
        <property type="gene ID" value="Gr19_v10_g17758"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF30">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="404"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="550"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17758.t1"/>
        </source>
    </evidence>
    <sequence length="636" mass="70308" checksum="43874B6F97E9F9B2" modified="2023-02-22" version="1">MFSAKSQRKAWAPRATAHNNNNNGICLGERRSLPVNTSFRGTYNWGPSNAKAKNSNGEAATALDTSPTEGNLPREAYCTVEEIQLGKRHSKSPIMGNGVGTGRVQWRHEHPQQLQGKQDEQQQQQHQDGDDELEENHYEDGDDGEECKKDRIGMMYRHQQQQQQQQKTSPSKVGIFDKKVQPLPPKVPPLPPPLPPPKLFGNAKRELKPFGKTNLARFWPALAFLAFCLILLSIAFLSLWVANNNSEMRRKNQMNWPLRLVPMPTSTTTPHKVPPKVLPPATLSGQKGGEGGEEEEEEEEEEVSEAPATSPAWTSSEARTMETQSATPSSPKASSSSSAPEASHQFVVQPEELVRWLDDGQIRRRLRLFEVRDRNSFPTTPAALPPAKVLLLSSLSHNGVPVHPLQFQRFLRSEEVDDGSVVLLYDVQSPQQLWAHYALWIFRLFGLDNSLLLMGGPNWTVNGTSLITLLKGLNVPPNVSPGHSPIGIFQAQWRAEFIATFDDVLANFEGDNAASANVADIVDAQTEKEFDGHAPSVPGPSSSASGAIFGHIRSAKSVPVETLDGLSPEGQRTLFHAQFGLSPGRPIIVYDGFSSHRAAFVWTALLRANFSAELYFGAWPEWLVRAPDHLKVIPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJK5</accession>
    <name>A0A914HJK5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJK5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17778.t1">
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        <property type="gene ID" value="Gr19_v10_g17778"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
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    </dbReference>
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        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
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        </location>
    </feature>
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            <begin position="166"/>
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            <begin position="197"/>
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    </feature>
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            <begin position="279"/>
            <end position="299"/>
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    </feature>
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        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="669"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="699"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="738"/>
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            <begin position="762"/>
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        <location>
            <begin position="489"/>
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        </location>
    </feature>
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        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17778.t1"/>
        </source>
    </evidence>
    <sequence length="784" mass="86456" checksum="92476352ADC8AF6A" modified="2023-02-22" version="1">MALSNILTQFCRRKRLNSSDGQLHSEWDRRLGQCSLTTIVATLVLALTLHVILPAIFSHYTIGKSKMLLLSPIISLAFTSALIILAAIQLASISRRIGRNAALYQLAHGTFGQALAVAVAWGQLLDQIAMAATVCHALSDHINLLFHNAFCSLRLPSPIWHGHDVVLLDLLAAVVLPFCAALVMMCSVRVLITSTTIFLIATMFTSASTTTVAFLHNMAQLHVFGNSEHPPETASFLSIDELFATFRCWLLAWPCVELLSFLAEECCGPRRALATLMRAASRVQPALALLALLAFFPFIRLDTSVPLDDVATAAVASVVVHQPLLPLPAMFNSIRLFSARYLMNVGSVCSLWAALLCLFLAPTRLMATMAMDKMILPFGHKHLASISEKGGQPRCAVILVAFCCSLMVGIVPQQWLGRLIPLNCVLRMALQALLVYMSHFTPSSSDRFIGGDLRPKYRRVRRVRAVSRAAQQLQSTEWKMCEEAAAVDDEDEEAEEFGEESSSISADESEDEAWLRECREREHLLERIWRLATADTTETEQHQTAHLKSIDTPLLELNNQPHQQPPNCADYQSIQNGPPCCAPRQSSHLPRQHGQHGQHQRHNCFRAPCSATTMTVNGRTVHTVPLPGLHVYESEVPQSWLGAARRVESGTKAAATCDERAACDAARRALLLAFSAAAVCAAAITALRKTSDDDYLPLLPLLALLSSIVTGCSVIVWLCRLRVDYGTNQQQPLEGKWLPIGALFSMFTLMQLLPFFPPIEWALIFGWILIGLFLHALRLARSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJZ1</accession>
    <name>A0A914HJZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HJZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17318.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17318.t1"/>
        <property type="gene ID" value="Gr19_v10_g17318"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
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    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF30">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037965624" evidence="5">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17318.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16935" checksum="358BCA68898F87B1" modified="2023-02-22" version="1">MFCSNVSICSFCFLLLLLLIQPTIGRQYRINGTLKCHNLEGIRPYQSEALIQLWEADVKLFGVIDKDDLLGETQSKKDGMFELKAKDEWELGELEPYLLIRHTCWGEAPQEENCALLSRMDLQPTPETKMLLPIILGKESQLETMVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK52</accession>
    <name>A0A914HK52_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLAVATA3/ESR-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK52"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2219.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2219.t1"/>
        <property type="gene ID" value="Gr19_v10_g2219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037587345" evidence="2">
        <location>
            <begin position="22"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2219.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="28849" checksum="917335D2A147E2DC" modified="2023-02-22" version="1">MAKNAMLCLLILSVVLALAFATNEKDDKEAGNHSTGIFGKAGRFVTVALAMSSRLGGAGASQGGGAVHGESLKSNQLQNAYRMALPPPMPMKSAEVGGILVELAPPPLVPMHSAEIDGWKPSPDEYLKKFAQEFRRNTGMKPQSYNEEKRVTPGGPNALHNGYVNRQSPPNPPHHNQPTLEEQKRLTPGGPNALHNGYVNRQSPPNPPHHNQPTLEEQKRVTPGGPNALHNGYVNRQSPPNPPHHNQPTLEEQKRVTPGGPDRQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKA3</accession>
    <name>A0A914HKA3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKA3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g191.t1">
        <property type="protein sequence ID" value="Gr19_v10_g191.t1"/>
        <property type="gene ID" value="Gr19_v10_g191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g191.t1"/>
        </source>
    </evidence>
    <sequence length="329" mass="35817" checksum="DA335D3F8099AA35" modified="2023-02-22" version="1">MRFLFRCALLGTVLTAFLIVLAIQRHSVKRSSSTTVGWYAAPGYGGNAADAAASSKSAEQKQNRQELPTNEDHEIRRLLLAGAASADDTAPASRLDGASSAEMAPALMLRFPRFPPAIGGGGGTSGAEMTLNVAIVLLVSLLSIAILITAICCVIIVALALDTSSTARRWSARPSMAATSADFFLSSWPDMATQYHQLSQSPIYRTPGLDKLFQQQQQHHHYHYDYSLQQADLMAILHDAPVDTPPLTDDDYEISDDWHGHAQSRGEHRQRRNSFTIIKISPLFWSVTQCVPPAVQIHALAVEYTLNRISSSNPAAECRRPPAHWAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLY3</accession>
    <name>A0A914HLY3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2 13">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2 13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g179.t3">
        <property type="protein sequence ID" value="Gr19_v10_g179.t3"/>
        <property type="gene ID" value="Gr19_v10_g179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000011">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056586">
        <property type="entry name" value="EF-hand_PLCG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057061">
        <property type="entry name" value="PLCG_EF-hand_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF159">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23329">
        <property type="entry name" value="EF_HAND_1_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23583">
        <property type="entry name" value="EF_HAND_2_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="710"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="828"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="946"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="1056"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="19">
        <location>
            <begin position="1144"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="1355"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1281"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1521"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1281"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1300"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1334"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1521"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1550"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g179.t3"/>
        </source>
    </evidence>
    <sequence length="1689" mass="187161" checksum="F8A72822F6CB83CA" modified="2023-02-22" version="1">MAPVPVGAGGGGGNICRKRSEHGKCGQPSTMNAGGVFAKGAKKGDAGGGHCDKASNGGAGGGANGQHAALDSRDFCVMEKGHRVCKLFVSKKFDIVFRHLWLNMHTHQIVLTKLVNEMPSGDEPGPSTSSALGLFMPNGLLSNAGRKTSAAMSSSECAKSPFCSPYAKSQMLDLRLVKEVQVLSKAVGTMQIAEKWRRDSSLQTFDADLILVVQWGAAFVLNSWLILFNTKEACQLWCRGVQQLCADHAEQSHALVVERWLRKRFFALLPHPTSAASVSIKHMKPFVQQRLQCKVNSKQLQEITEGEMGFESFVLAHNHLLNFHALFESMFSEYTDSQNAHAVSFQRFVDFLRDIQHDGLGQSKQLTSDFLRRYLRDVDPDRDVPEPSLHTDEFMEYLFSPENSLFDPVNYEVVHDMGKPLNHYWISSSHNTYLTGDQLRSESSLDAYARALLMGCRCVELDCWDGHQLNVVVIYHGYTMTSKLQLRDVLRTIREYAFRTSEFPLILSIEDNCSLPAQRQMAVDIKLVLGDLLLTAPVSRDEWQLPSPAALRRKIILKHKKLQLHNDTDAVLSAHSVEDELEQDNILSRRCTKKGVLWLREDGTSGSSANANANGVHQQSNQQQWHKHIFDVPAASGSTTTRAASGSIANDGTSEFGTLNGRGIANGGQRKLLAGREDSLNSQSDDTYLDESAGPMAADACADAHVAEEWFHGKVDREEAKARLLAAHHNGSSGGGTNDGLFLVRESTTFIGDFTLSFVHGGGVHHCRIKASISTGGERKYHLLDSVKRDTLYELISFYTRNALDTPNFKTYLQTPCPQPQPHLGKPWFSAHADTEQAEKLLNAVPMDGAFLVRYSSTDKTVFVVSLRIDNKLCHYRLKREGRLFVMAQRMFDSLCQLVDFYAENPFVRGVSLKFPINEQTISQYTDQNGGQLQLDGFYVDLNNLDKEFRVEAIESFDGVGDEHQLSSLEFKRDQQQSFSPLSFPIGAHITVLSMDKNDVHVDNDDVDDQKNNIYEGRWVGRHNDKTGWFPAKCVRKLGGATNGATDSSNNTLNYGTIELAGTTFKQCEDSDPDDRSRCGSRPFAFRITLAQSHWDMREYVLAADSREELDEWLCACQQMAANASDKMRQLRSREKQSRIASELSSLVIYCQAVPFNADFELQDSRTSFYEMCSFSESKHDKLVERGLQLFNKRQLSRVYPQASRFTSTNFSPMPMWNSGCHMVALNFQTGDKSMQLNAGRFMANGCCGYVLKPRYLMDETFAIGGAREQQQQQQQMFNPPLTTLNQRPSLSSSTFEVDSSDKLKKGVKQLNDEHPKMSSKKNGGTFAEDPSFGETNSSKSRPVQSVQHQNHQRQKSKIELNIPQSLGVGSAGGSCPIALSVLVIAGRHLSRSGACDKGGGICSPCVELELLGFTHDARTLRTNTITSNGLNPVWQERFVFHVRHPEMALLRFHVEDGDFVGPKTDPFIGQAVFSLDSVRSGFRSVPLRNQFSEPLELSALLVHVEIRTWEPPFLHGIGFPTSSGRRSNSNSLPSSSSSSSMLSGLTTTFGQHGTLNHSKSIDKAAQQQCGPPIHNPHKLLQAGRSILAPERRTSLVIADGISSNSAAAAVGANEEIIGQHLPPLLRGPLNRNGSLETAPSHQQMNSLNSRSISVESGDNVKPLLSSARKTGTNTLRRIFRLGGKQNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HME1</accession>
    <name>A0A914HME1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HME1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1908.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1908.t1"/>
        <property type="gene ID" value="Gr19_v10_g1908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037824206" evidence="1">
        <location>
            <begin position="28"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1908.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="47068" checksum="3DEBB9CEEA3DA304" modified="2023-02-22" version="1">MKVFALIMLRCALVMLLSSLLQNGTLATLGEWEKSCQELKEWAALCQLYVIPISFSLGLITLDDLSNIPNINHSLDVLLSEVNNFRLEGMDELKDRRLQKPLKMAISNCEKLLDEVKQSGLEDNKKYLESLVSKTSSIANGIGKEFNTFIFEVELELFTKFYRTLQNRGKLSNKLLDLAKFSTNSYRMGNNPRYEPGTPEFVDFVESLILNAKLKILETEFYSKIAGLAEQQPLNDGDGFLEFSKYFKVEWKLIEKMIGQLTSNDDKDTFRKRLDNLGEKAMEETAPLKAIITEKFDQLITKCQNSLGKFNKEEISNQPVVTKLKNALKKLLKPFKSDQNKQKEEAKKKEIDAMKQIISDIGMFDGAAYKLLVRFEHEELGKTDFCAELEKAVEQDKKMVLQAYQVKDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMI3</accession>
    <name>A0A914HMI3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMI3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2161.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2161.t1"/>
        <property type="gene ID" value="Gr19_v10_g2161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2161.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26713" checksum="F78F646532616113" modified="2023-02-22" version="1">MLYRNKLKMQPKQIPRELMAEMACWMPYDKVVKAELKADQEGSTNMTPFDCYRRERYAKLLTEVRNIAATLDSEKTIQENANSDFGATHFVQGDPLFFPIFAKWERGTNAIAKLICYGKVAFGVDKSIVCKCEDGTSPDGLIEFVSTSPNTPLMIQEVELCWGRPIKWPVPLQGVKPVGEFGQGGKRFIYYELANKSSGQKYIIRIGGGERCRRGETFQNVQIYRNKDPFPNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMQ0</accession>
    <name>A0A914HMQ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMQ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2917.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2917.t1"/>
        <property type="gene ID" value="Gr19_v10_g2917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2917.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8854" checksum="7BE7D4E76E6C3257" modified="2023-02-22" version="1">MWQLILGIKHEAMTGRCSAFERLMLLLRLQSKSKQLHHPHRTKGDGPTADDRLLKAQSGARTVLVRVDKIELRKSGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNV4</accession>
    <name>A0A914HNV4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HNV4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g232.t3">
        <property type="protein sequence ID" value="Gr19_v10_g232.t3"/>
        <property type="gene ID" value="Gr19_v10_g232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g232.t3"/>
        </source>
    </evidence>
    <sequence length="111" mass="12755" checksum="4EAEEE9F0CB901BC" modified="2023-02-22" version="1">METVHPRQRSEMIRIKKKHGPRKGMGQHVVLGSKLKARYIDELKFVSARYLNKEIYVRSTDMNRTLTSAISNMIGFYCSGVPGKDYPGKKEAHLWPHGSEGFSIHCFFVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP25</accession>
    <name>A0A914HP25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2378.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2378.t1"/>
        <property type="gene ID" value="Gr19_v10_g2378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2378.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12895" checksum="1FFDD8C975BD15DD" modified="2023-02-22" version="1">MALKLSNALIDDQTRSWEIIWHRIWPLVKDNICGLDLYTFQLDGWRQFSPTVLNDCPKLRLIHCDTIFPAFPANDSAGASSEQALAKWLCTPRGDGIPKALEIYNFDSERICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQB2</accession>
    <name>A0A914HQB2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQB2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3255.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3255.t1"/>
        <property type="gene ID" value="Gr19_v10_g3255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3255.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7970" checksum="6A3D2DE659DF696A" modified="2023-02-22" version="1">MLLRKLFNFYRIYEESKKVDGNYRRYGADRSRCCNLNIDVYSACLRSFCPMEYEQPGDGVLKSTSKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQE1</accession>
    <name>A0A914HQE1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQE1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3482.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3482.t2"/>
        <property type="gene ID" value="Gr19_v10_g3482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3482.t2"/>
        </source>
    </evidence>
    <sequence length="287" mass="33011" checksum="62D86B735D1CA926" modified="2023-02-22" version="1">MNTLELPMGPALPQNGRIAPAQLLANRDEIRSVWADETEFCADYMIYAFQRWIASKIQGKHVAVLEPFFTQNFGPDTLGLDPLDFCFNYSENYDVLLITVMYPAHFALLIFDRTSQPPECIFVDSLPPVLNENSPFDDRLYDIRYPGYDQNRLRMLSETICRLTPGLQPTDFCIRIATPDEFTIQRDGTNCGFFVSLYSESYLTTNRSLILPNLNIGVERRRILWILSQLLLTNDVPYVPREVSRIIEEGQHTPTHSRAVRASPNNTPMSPTALRIRMHRRSRKTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRE4</accession>
    <name>A0A914HRE4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRE4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3761.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3761.t1"/>
        <property type="gene ID" value="Gr19_v10_g3761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3761.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26052" checksum="3E04DA4B83241160" modified="2023-02-22" version="1">MAISGAAECGCFGSKRAHTTAGSGQSTRRQQQTATTSESYPLPIPQNRKSSSKKSKRRLHPDHHTQYQFLQSRPRCCVFVLLLGRIYTECHGLQLKGRIYTHCHRLLLPKIRRHVAKCQCQKQREDEEELIDECGDIIRTIPIANSSKSNVRRHHPGSGQLPIPQNRTSSSKKTFKTAELAESSGSCQLPLPKNPVPSSIRPVKSHLYRIPQPPALGGLPLPNPKGKEKMKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRU5</accession>
    <name>A0A914HRU5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRU5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3655.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3655.t1"/>
        <property type="gene ID" value="Gr19_v10_g3655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF10">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3655.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16008" checksum="E715BB42C6B36282" modified="2023-02-22" version="1">MAAFKKFFFAGKDENVNYYELLGISEKATTDEINQAYRNCMKVYHPDKSPNGKAMSQLITKAKETLMDPRKKAIYDGQMYSYATMDHEEPMDYAVVEPVFPKFGEVLKMNQCEEVAKMMEQLNAKAAAHGGLSEGKFLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS67</accession>
    <name>A0A914HS67_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIIa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS67"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g374.t1">
        <property type="protein sequence ID" value="Gr19_v10_g374.t1"/>
        <property type="gene ID" value="Gr19_v10_g374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12100">
        <property type="entry name" value="DD_CABYR_SP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000055">
        <property type="entry name" value="Putative microtubule-associated protein futsch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047579">
        <property type="entry name" value="DD_CABYR_SP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699:SF11">
        <property type="entry name" value="IGLOO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699">
        <property type="entry name" value="NEUROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="2">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g374.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38920" checksum="096DD8BD1CF5306B" modified="2023-02-22" version="1">MLTSEEGTGGPLDVCVSFSKRHGLFELGNRRHRKSAIRAIQSQMKETTESADPISQKWLRMDDAFSHIISAGRDENLLCHFSGGDWEKRIDVTTFKQMAAANANTDRASGNIARGQESKYKLPSGLRPLLEAFARETLRSQPADLAQFGQLFFETLIEHKKRNSASSVEDLLGDKFNYDIFRSELHQKLKKARQHNGRPSSPMDIAATKIQAAFRGHLVRTQPEKFGLDAELMNGLNMRRNSNERLEAADNKKDLKRHSIGGYSHAEQINATPEDRAATKIQSEIRGYLARKHFEQQKKESSEAATKIQAQIRGFLTRKRLEEQGFVLSPPRSRASTRASGDAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSN2</accession>
    <name>A0A914HSN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3854.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3854.t1"/>
        <property type="gene ID" value="Gr19_v10_g3854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037525400" evidence="5">
        <location>
            <begin position="26"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3854.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30104" checksum="6C2DB3A5BC042CAC" modified="2023-02-22" version="1">MLLFFFFLVGLLIIFIFYRKEEVNASSDEKTGSEDDDDDEDEDDDDDDDETAEMVFQFSEFFGAERWRSTIKAGILENVLAALNGHLKAVEILLENKAEYLRATFEMTNGGKTTRHLEVVRRLLKVKGTDPNEGAKLTIDGKEITGLSPLCIVTSESICNLLIENNANVNHQMGNGQTPLFCACIRGNLEIVKCLFVNGADINAVDKLGRTPLMAAAFHGRAGLVRYLLEKGARIDLATTEGGRTAQNFADQSGNREISKMLREAAQRTAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSW4</accession>
    <name>A0A914HSW4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSW4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3661.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3661.t1"/>
        <property type="gene ID" value="Gr19_v10_g3661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3661.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="40100" checksum="B348F0CCF6ED7DD7" modified="2023-02-22" version="1">MSDNPKKVEKQMKRILISDDVLFGVFAFCDPFVLGLKFALISDRFDRLVDAHFKLKEWSLGNLHIGRAIDGEDAEIVNRFGTEMDDRGLPSPQVPLPAKVTGFERIDINCIDQSVIDFLQNIRRLFKPKKANLSIRIGDNQKLSLEIIWHRIWPLINKNICVISVDYAELVRLRRFSPAILGDCAKLRVIHSDYVFPEFPADDSAGASSGQAVAKWLHTPRGDGLPKVLGCRLLLERMVQLKQEFFKSTDSFNFIIYFTAAYIVPFELQNNLTAERLVCRRIAQNLWLLVRCPIERDEDKWAKWEKEATEWDWCPWNYIYINVKDRDIGDGMLDTNEGPSEPKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTH4</accession>
    <name>A0A914HTH4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTH4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4312.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4312.t1"/>
        <property type="gene ID" value="Gr19_v10_g4312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4312.t1"/>
        </source>
    </evidence>
    <sequence length="667" mass="75781" checksum="E116EA64A9C3AE8E" modified="2023-02-22" version="1">MLKGIGSLNLFSSPSGENECVHSRSIEELIETSLEHFAIDDAVVLAEAYCNRVGSERSLLLLAHCLTRTQNLENAYHFLKMSNPQSMKMAKSRYMFALCAFAQDRLQEAESMLRDDKVVDKVELHPVFFGTNSLPYAHSLLANILRETNRVECAKSHFASSIRNCAMLWSSIRSYCELGGESVRDHMQPLVTLVSTENALRKSVSEERQAQQEDYVMSTPVTKAKAVEERRRAFTPERRRATRLRSTASDGRFFAARTLSTALRASENSPLTRLNKVNTEAALKQAIIAPLIESKQLEDGDEHELSNKRITRRAAAAAAAAVSKETTNYEHWPDLIHHEFAGWFVQLAVVQECLSRFRSSEALAILQELNPFLAQLPLSLELRARIFFENGEYKRSCEVFEEIRRLYPRHLHGMEIYSTALWQLHDSKKLSALASKMAEIARNQPQTWCIAGNCFSVEKQHETAIECLERAIRLDHRFAYAYSLLGHELIDMNDFGRAAQAFRKAVQFSPNDYRAWYGLGLVHFKEEQLPMARINLLRAVSINPNNNVLLCQLAVIEQALHNSDTAMQYLESALKHSPNNVPCRFHKARLLFDVGNYEAARVELEELRVLSPDEAHVFFLLGRVNRKLGNTHLALLNFSWATEIDPRGEQNNSALTQDKGPYDDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTV2</accession>
    <name>A0A914HTV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTV2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3921.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3921.t1"/>
        <property type="gene ID" value="Gr19_v10_g3921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038023759" evidence="1">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="95"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3921.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19274" checksum="526480438564F865" modified="2023-02-22" version="1">MEELWILILVAFFTTNSPDKAESVKAKLEETPLSTFNEIFGEGWWDKDEAFNNSYSNQIDESVAKKLGLSYTTIYNWKSELGQPIAMVFRRSTNGIDHRFLAPYNPMLNGQAKRFVDTFKRAFRKIKGEGAPSKAIIETILVSYRMAPCDSLNGHSPAEMFLGRSLHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU23</accession>
    <name>A0A914HU23_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU23"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4205.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4205.t1"/>
        <property type="gene ID" value="Gr19_v10_g4205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4205.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8334" checksum="08A1312461FC27F6" modified="2023-02-22" version="1">MEVKAGGKKVPKKRSGDGEEMTFLQKVVEAEQLQVQQMDNSYDARGAKMDCGLNFGTLFYHIRHFSFCETAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUE2</accession>
    <name>A0A914HUE2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUE2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3864.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3864.t1"/>
        <property type="gene ID" value="Gr19_v10_g3864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3864.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26043" checksum="042983821A51E67D" modified="2023-02-22" version="1">MALISDRLDVLVDVHFKSREWSLGSMEIRRAIVKPRELSLSNWLRIRRATDGNGAQIVNARSGERLPIPQEPPPGKVMGFKHILIGYVDQSVIEFLQRIRRLFDSFGTNVFIGTLNNQSRSWENIWQNIWPLVNDNICGLSLDSSQLDRLRRFSPMILRNCPNLRSIHSCWLFPEFPALDNSDASSHQTVAKWLITPRGDGLPKTFYCGFYMGGMEGLKRFCQCFGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUM5</accession>
    <name>A0A914HUM5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4147.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4147.t2"/>
        <property type="gene ID" value="Gr19_v10_g4147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase central" evidence="11">
        <location>
            <begin position="1518"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1199"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4147.t2"/>
        </source>
    </evidence>
    <sequence length="1814" mass="209233" checksum="F0888EFF7CE7819B" modified="2023-02-22" version="1">MSLKTLRSLGEGGKNAVSNRKDPNPNGMPGHPTTVTGIRPASTLLLNEWHFRHKMFRRIVPSLCTAQGQKMPGHPTTVTGIRPASTLLLNEWHFRHKMFRRIVPSLCTAQGQKMPGRALLKMAKCRVIHLIVLLINSLTAYEIGLTLNEMDNIYSKLLNLPPADGSLSTSKLCKLWKFWHELGETFVNFHLLANEFELVIKKRINPDVNAVECSQMENIGPIFVRPLQMEIFERDIKLAHFSAIMFLMHPQKESELRIRIGGLTKPGNFVGDFSQFFGTERLKFETNFAHRLRVWHITGNVEKIAGVKIMTATLFDADILERIEFHQPMTMALEHVDDGRLAVEYAKMLFSDNLDKYELKLSARMLFGRIWAIFTKVHSLEQTKKAQNKKQGKNLAKIEQLWNEQVNALMEYFINVDNGKLGQIYEFWHKLAILNNKIWKNEAFELVQMKQIGNLQQIMHQILLIIRVELIDEHCETMARLFESENAFSECLKKSRIDGTGTRQQLLAFLASKLDVDGQSLGWNAFLSFQNIGKLLRINLTAEEVNQLQIRNYVKFLNFDTDETESKKTHLLLDLLAFYQWMKNRLGTLSAKSANFLKQNFELMELWMDAVGALKDGKEADKQREAYNILTQKVAQIYFRGDKLWQNDDGKTENGTKKWENTLNKLHLDILDTLLIDRQEFGERLGDIYLNSKRMAQMISSDSKVFVNLLKKSRNTPNFQQNNGEEQQKKRGEAPEEEINEEDVDIHLLMVSYKNLLLLERTCNAMAKKRMTVDSALFVHKTELRRLLNLVEAARADFFARPTATEEKLRSICLIKAFSDRIVRNGTLNESPQWRAELNKIIGIFYLFKNDETSDRKLLNSADCEHPQFVNAILAELNKSPMVEMIHIFMIVLLTQSMRDFAEFVVRNAYSLPKTRFYTHIDDSERIHFYNLILATDDPNQALMNESVLSLKLLINSAKTMEAQSFSDAEIAMPKAQTFATKDDQKTNELIRILREKSSAIARLELLVSTNLIGLLLGAPEIRAKLLNTNWMFDDSFKCQHLPPEEVAQFSYQLVNLVQKVKEFILSNKNKHLDGPKLEKCWNNIKESANSEGRIQWINSGGKAAPPSEAIAQWHFEALQKDSADGEQSDEEANEMFQKIIKGLNENRGHRKKLTQLLKLEGIKKLFNLHKINENKNSENAVTNSIEIRQQNEQKIAADKKENEMPQNETDNSAPKFEQKEEKEINLKKLATELAKINSFAAFCNDLILFEKYKEFILEPFEEKLKIVNIAAQVNEIEQRVKEIEKLFRFFQFNFGPMEFEKAKMGKSKMLWQIEIDQQIYEKINSKKESDKYLLPNFPKKSQQLTHFANIAEEMKFVENLENHLTKEAKSEDGNNSKERFDRKIKESLKKIHKIVDEWNANVRGLVKINYGTVFLIKFQFDGIEFDLTFVSIPSRKDLPVQINDESIKSFLDKFAIENSDDVKMLRVLSSYRSVRYVANLLSLDTANGDWTRILNDDAAGDGHQSVHQKSSKISKQFRNLLLSLKLWTKKNFIYSNRFGYFNGAMLTIMATKIMLLYPNASLPFLYEKFFLIYSTRPFDVPIQLKKLENASKLNLLPPINLTEAQMFVFTPSFPEQNAAKFVTYSTAKVIQKEIIGALNDIKSMGIGNYFDWALTNSTPFTEKFDYFILVNCAGEVQIGTDKFCQFVDGRIRLEFVYEIGIETRLYPNYFGQTCQIPKHFEAFNGKGIVTNYCKVWLAGVSLASAPDDLGESLSKMLNGFDLAIKRAYLRFNPTKDGVQNEGQMSESDEIQTIYRKLKFDLKSMLVERRRLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV89</accession>
    <name>A0A914HV89_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HV89"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g499.t1">
        <property type="protein sequence ID" value="Gr19_v10_g499.t1"/>
        <property type="gene ID" value="Gr19_v10_g499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF171">
        <property type="entry name" value="ACID PHOSPHATASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037251705" evidence="3">
        <location>
            <begin position="24"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g499.t1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48529" checksum="4BC0C7E596736A62" modified="2023-02-22" version="1">MPSLPSLFRLSLLTSLFVSIAVGSSKLRHIQMFFRHGQRTPTTFLNFPNENISSFPGTELAFDLGEMTTEGMWQEFVLGQKVRSLYGQFLGESYRSREICALSGRDNRTIASAQLMLAGLYPPRGDQIWNRHLLWQPIPVETVPILDHVSFGMFDDCAAESDRVKKSEEYARIGKRFELLTEELSENTGLDIPNLEILQKVIDAIVTRSNLFAFLPLPKWASSDAYIAKMVEERLQLHQQLIDIFLEPIGGWHFDQLIGRMDDAANNRSRQKAAFYSAHDTNILSLGRYLNISPVNDMFFPYAGFVVFELYQDNDGQHFVEVKSHPQLNGTLSRLDIPDCAHPCPLSRFRTIRSRTTTVQWMSICSGTSRDECSVCGSVSGVLTVLMVLLLALLCSLLWSCRSYKRRCEQLMEEKEPLLAGGKRKVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVD6</accession>
    <name>A0A914HVD6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATOR2 complex protein WDR24</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVD6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5021.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5021.t2"/>
        <property type="gene ID" value="Gr19_v10_g5021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16693">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="999"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="WDR59/RTC1-like RING zinc finger" evidence="8">
        <location>
            <begin position="878"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="684"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5021.t2"/>
        </source>
    </evidence>
    <sequence length="1085" mass="121115" checksum="AA810406EAAA1128" modified="2023-02-22" version="1">MSPIVAETYEALESLSTNRDRSRVAVIGRTVAKVYAVHENRLELRTERSKPRTAMYFSGSIAWSPLKENLVAAASSNGCIFLWDPQSSHSIERAYKAHKQLATKVCFNEFNENLMVSGSKDSTVWLYDLRSPEPSTCFASNCDDSIRDIQFCMESKLQDTFVTAGDSGTIRFWDARRPDRALKEFIAHSSQVYSVALNPQPQSKNLIATAGRDKYIRIWDWSKNTPHFIYTVETMAIVTRVSWCPDNSWHVACCFAPPSGFVYSDNIVYVWDIRRPFIPFASFDAHSKTCTDMSWSRFGSGDRFFSCGKDGKLIINFADNAQHPILYANSVALDANSPFDDIAVAVPSDLRKSSSIADPFRRKVPSTLFCAMPSDPFLMTARTTAYFAENYKMIGGTVEELCEHNAKAAERIFRDRLAYTWRMVALLCTQTELGAIRPKFSSAAKTSMQSVGGGSGGTSNHFHHRFRRSLSSNYLLGKDHQEISHHRYNYKNRILHGSGHSADDRTAGLPKLDKDFPSTAAIPAAMRVSGSLSVAAQQHGECDAFGALDLFFGADELNLGGIIDFGFGDQQLEKGAMNCISRRSIISSSIVDLSQLREEAFAMHSHGTSANRRRKLASDGTMTVETFCVRQKQINRKRRTPRRQKSSPFFGCDALNSKSTEGSFDLDKNDVRDENDRGDVEGMASNSSGNGSFASSIPPFSPSSAFESDGSHGNKVKLGEDEETEDESECSNEDEQLSECDLLEQISSSSPNALQKCNSGALLFFDPIPSLRALFDHYSSMGDIQMSATLCMIMGERVVESGLVSAAQAELWLLGYLELLERLRLWRVAALLVKCCFRPKINQLSIESTFMKVWCTSCRNTALSRASPRCKSCQRLHNYNCCICETRVRGLWTTCNGCGHGGHLEHLREWFAQWEQCPVPGCGHLVKRQMASLVDRFLMKWNGIPMLFGAATCGTFYALNNRWFRGQYVGGKFGSIDMKTAEQLFQERRRKELMMHLEAASYVGSVALSIIATGAILRSLPKKFWFSSSVGIVVSGIGFRIGALVVGALLVDGPMYAYTEWLQKRTEGRQEHRQEMLTMAQPNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXN0</accession>
    <name>A0A914HXN0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXN0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5075.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5075.t2"/>
        <property type="gene ID" value="Gr19_v10_g5075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="895"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="973"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1054"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="8">
        <location>
            <begin position="168"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="9">
        <location>
            <begin position="927"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5075.t2"/>
        </source>
    </evidence>
    <sequence length="1132" mass="125048" checksum="5C0D8A2C2AAB57A2" modified="2023-02-22" version="1">MDRWKHQLRKRWEESGLFHWQKAKNVGGQYVKLLYTEQTMAVEQLADLFPLARIDVHEVLSSRGISHDEARLRLADQCRQRRTRRVRAAFRFLRQFTLSAFPLLLLCSSLICLLIALIDPSSAQSALPMALFQGAILAIICAIGAFGRSRLRRVGNLFQNGGGQVHFVIREGVRVPMRERDILPGDLLWVEAGQRVPVDLRILWANKQFRATANWLTGRPEAMRFTAEPAPRHAPDLFRVRNILFAEFACTRGASLGLVIRTGKNTLFSRLLSMKTFFRPPSLEGPSDEYGRQGQRRESALRQSYRSFVRSIVWLSLGVSTGALLLSLLLTDFARPLYSFVHIFLIVLIVSVPQALPLTLSVQLLLVARWLRQKCGGMLLRQAGVADALGRTSVLMVHSSSVLSSNCPTVTDLWLAGQNKMINAAHLLVPRVNKKHWEKEKAMDQLLQTVDLCCVERDRDRRRPNSEHRRSADVEQQTTGKKSLLNQIVGHLCQTSADHSEEFVMIGHPTDMAFSKFLCQINPAKSSRLLPVREDECPEDILRSIDRPSSVDLMVAKWEVPADTSNDSNAFVASDDRRLAYRLMLRGPAEEVVKMCTMVGGRGGGDGRDSELIDEHHLAHFEDAFLALSSQAKSCVGFAVLDLFDDEVDVLPVFSRGSFSGRSFSVGSDSNGWSFLGMLALANPPGAKCGTQLSELASGGVRLVLLTDQHPIVAEAMAEQLGFVAKSVKVDETAKISVIQMPLELRFDGSGALFGPKGLRKNNSFSSSSGYHSSERGDNENVTKGDKRADIVADLSDDLGKTLFAKMMASGGLRHSVFSQLNLRQVLALIKELQLHGHSVAFVGDDPLKDAPALRLADVGIAQNDGSSLLKEASDVLCANVQLGNLLKAIGEGRLLVANLASTLAFSLSFTVPALLPVLLSLLMPLPSGMTPLQTLSVTLLIQIPPAIAMVFQRQTGPLRTQKIRKPLAPCGLLLYVHLLRILAINEFWSETPINSTTIHFPAGVSSLAQQNQLIGQARAAWLLTLGVSQLVHAWICAGFLRRNWRDGTIFRNWPLWVAVLLDLSLLSLLIYVPGLNFSFGAEPPPQWIWLFPVGTALGLLALNASLKIAIRIIRQRVSKTCATRIASLVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY89</accession>
    <name>A0A914HY89_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY89"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4897.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4897.t1"/>
        <property type="gene ID" value="Gr19_v10_g4897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4897.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="8403" checksum="0B2CB8D63AA26589" modified="2023-02-22" version="1">MSDLSAYMSSPSAAAPATGGAQSAYMSSPGGEAPAPGGEAPAAGGGGGGAQSAYMTSPTYNQPEPTPAKAPEQSAYINIKLLLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYW4</accession>
    <name>A0A914HYW4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYW4"/>
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        <property type="gene ID" value="Gr19_v10_g5364"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036835960" evidence="3">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5364.t2"/>
        </source>
    </evidence>
    <sequence length="111" mass="12433" checksum="A97C3F95FFAC7AD6" modified="2023-02-22" version="1">MSNHLTKPTLTFLLVLIVANVNGQYGYQYNNNQLYLQQQQQQSLQLCQQQLQNLQQQIFSLMQNQKEQAGSVPSANSNNTREADAPDSENNLLDVAVGKNSSPNFVKSAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ91</accession>
    <name>A0A914HZ91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5395.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5395.t1"/>
        <property type="gene ID" value="Gr19_v10_g5395"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF115">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5395.t1"/>
        </source>
    </evidence>
    <sequence length="502" mass="55125" checksum="7634BD7D3FFAAF6C" modified="2023-02-22" version="1">MESVVLHGQNYNKKCQFGKRAVTPPNVLGRGGGGCILAAKMRMFAVALSIGAGTMFLVSLDSVVDNLIPVARKYLIEFYGSEKRANFAWGWVVSARSYGIAFGCFCAFLCSDCPSRKWPLVGSFLISFIGGILCMLIKVPEFGIAICCLGRFLSGLGSGLAQVIGSAMLAEIPQIRLRGTCLASLTVWACVGELAGLFMSLDTVLGTDETWHIALGFPVLIIPFTLATLLMAPDSPRALLLLGKENAAFESLKFYQNSEDWIPSLKDVKMELYHNYWPKPNGQNGTSQEVPLLEKGRGIGEFFALRCRFGTGKFVRPLIIGAFVLTLAHLDDWLWISYSTQAFENVGTAPSDAQRASLWMAFPQHLLFRDCHFCAIASGSAYSVAPELFQQSDRIMGTALIGISQNLFGGFLATIALPLMNGSGIEYVLVPFILLNIAYVVVISKKLPETNGKSFYEISEKFSDKMPEFPSLTQYLRAFTRFILIMGRKTVLLFHLIGKIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0N5</accession>
    <name>A0A914I0N5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0N5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6398.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6398.t1"/>
        <property type="gene ID" value="Gr19_v10_g6398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037459339" evidence="1">
        <location>
            <begin position="21"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6398.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36468" checksum="27CA86607F526CD4" modified="2023-02-22" version="1">MILLKLGLLFIVLKACGVYADEPPDKRWNICENKLVTVDEKCPSVLICYQSKLARDAGNWKAGNRFRVNSPNASIAYECAENDGTKGWHAVRISKDITGMMPLDSSFGSKSLSNVSNYPEINNDKEALTSDGQYAVEEYQNALRFGAFMIDFDGMPLQIAALEIRQSIGKNDTKMCKTKCAAKWESQTETPNLMQIEFSSDVPKFSLNISISPYWAACAVHQRNNKADHIKDNTKVSEVANQDQFNACSKVPTSSVCKKSLEFYACYESIKNQTHMKEIAETCQKHLSQAPFVAGFRVQICMHRDATKETLIFESRLEFSSSVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1J9</accession>
    <name>A0A914I1J9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914I1J9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6455.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6455.t1"/>
        <property type="gene ID" value="Gr19_v10_g6455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037892524" description="beta-fructofuranosidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="139"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6455.t1"/>
        </source>
    </evidence>
    <sequence length="663" mass="75942" checksum="EC19E0EF7A59E856" modified="2023-02-22" version="1">MLLLAFLFATSLFLIHGTGTEGVSRVNVLLLDDSTLHVWVRPVKKGEVAKVYLCPPTEAGTIEQSGQLIAECKQYSSDLWHDFIEINGKTAGAYTLTWTETTHASLVYVFKPKTVLEEGIRILFIGEEAKLPNLEGSYHFRAPFGWNSDTCGFNRSKDGLFHLFYQHFPHAVQWYSMHWGHAVSKDLINWVHLPIFMIPPNLLHLDFENGHFTGSSINLPNGELGVFWSQRISDVPRGTVAEYPWRELQQYVTTKNLIRPDWTTHKTIIERFPTVDPPLGNNFHDPVVFLGPGGYYYMTVGAERKNGSAGLVLLYKNKNKNADQLDRDWEYQGVLYEDKRNEELRMCECPMLIALGDPLNANTEWVLSYMSDGGSHPAPIRGTDAEGRDRMNPLFVGRFDGRKFEHRFVQKMDFAGGSFAYQGFYDKQSGRSYLIGWICDISWISENTENGQYLMVRPLPELASLREKKQPHVITKGQEMHLEKGQAELVFEFSWDNGREETFELHLTPTHTNGKKLEFRIDNNGLQLKRTWVTSNKRLVVYNAMPTKIHIFIDLDTVEYFADEGRWSGSIRLPEASQEKRIGTVELKRAPLMLKEASMWYLNYKAHKSAFLQQTANIIKMEPIKKHIFEKQKSSPKSVLDAEFGESPKKGELPALHTIGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I204</accession>
    <name>A0A914I204_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g11051.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11051.t1"/>
        <property type="gene ID" value="Gr19_v10_g11051"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6766.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6766.t1"/>
        <property type="gene ID" value="Gr19_v10_g6766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000081">
        <property type="entry name" value="Protein CBG24505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1121"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1168"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1243"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1268"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="399"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="740"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1123"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1448"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11051.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6766.t1"/>
        </source>
    </evidence>
    <sequence length="1700" mass="188884" checksum="5FD0C37BBFAE2A0C" modified="2023-02-22" version="1">MSFDFDYYDDNGEDVGFRWPNQFCSDPLWIDSGELGRENGSPSNASASGAFRPHLPVLTECMRHAVMSQIPPLFLLLTLPVMWVQLSSARRELCDTRRDRTIPRGILTTLINATTVLLFGLKAVLLVKSCYDWLWAGENVPIVELLYPIIHMVTLIVLLHYSEQYRLAGLVSSGPVFCTWLMFVIVGSVEFGFSLYTTDNNNVPWRSTTDFMAFLITLAWWPLCCLQLLLHLFTETAAPSKWDDEANSSPEPRASFVSRQIFCWLDPLVWRGHRKPLAERDVFGLEPSLRAKRLFHRWTRERQRQAEREYRSPGFSASPPTSNDHGSSNKHKPAEEGSPLLGQHVSRPQSYGGALADAVAAGVGSAPSSAGGGFVVVEPPVAPSVVACLWRLFKWEVSGAMVLKLFSDLLQFVSPLLLGQLITFTEDPLLPAWLGYLLAVGLFGASELRSLFLNNYFVMMNMVSTQVQSVLTSAVFAKTLRLSNGARRGRTSGEIQNLMAIDVDRFQQITPLLQQLWSAPFQVTVSLILLYKTIGWAVAGGVFVMLALIPCNLVVVRFTKRWQMEQMKCKDERLRTINEVLSGIRAVKLYAWEAPMMQQIEAIRRHEIYLLRKSALFRAITEVMNVTAPFFVAILSFALYTIPDPVGHPLTPAVAFVSLTLFSQLRVPMLILAEVIAQLVQTAVSNRRLKEFMVDEEVQEGAVQREQDPEFERAIDVEFASFDWQHKHRVQHDALPAGPAHRHALSQPVVCVPYTLNNVELHIRRGLLTAIVGKVGAGKSSLLSAMLGEMHKVYGYVGIRGTMAYVPQQPWILNRTVRENILFPISEDEKSDEEHYANVVDACALRADFTMLLDGDQTEIGEKGINLSGGQKARVNLARALYRRADVYLLDDPLSAVDATTGRHIFEQAIGPSSMINGCTRILVTHSLAYLNQCDWIVVLDGGQVKSQGTFTELLKDEQTAKMIARLDNEAAAAAAAAAEDEGTATAAAGVIAAGVVERNSSNNGGGHNNGGGHLASEEESGDNDDADEVISDVASMLSSTFTSSPHHLRRRRHTRTSSKRSGSKTTVASMHDVVTELEVDEQQQELEEVAGKLVKAESAETGHVHLSVYRDYFAAMRWPLFIGFVLFMLLQSGLSIVQSFWLSDWSDDNLSTEAAPPGTKMSLGVRLGVYSAEGMAIVVFLALSYVFQIMGSVSASIRLHGPLLERILHAPVSFFDTTPLGRVLNRFGKEFDTVDLRLAGTLRFLSISMLLVLQVMLIIAISTPLFILLDIPIMAIYILLLLFFIPTSRQLQRLTSVSRSPLYNLFAETINGTTSIRAFGVAQPFFDNFCNKLDTHIGFKYFSLMVNRWLSIRIELIGNIVILGSASLAVLSRQWGSTTAGLIGLSVSRSLDITFMLAYLIRNINDFELSVVSVERILDYMKCPQEASWRSPPGHEPPRNWPEQGEICFQNFSCRYRPELELSLRSISADIRPQEKVGVVGRTGAGKTSFALALFRIVEAAGGRILIDGLDIARVGLQELRSRITIIPQDPVLFSGTLRFNLDPFGTYADNELWSALDHVHLRDFVHAQPDALSHQIAEGGENISVGQRQLLCLARAILRRSTVIVLDEATASIDAQTDALIQKAIRSEFQHSTVITIAHRISTVMDYDRIMVMSAGQLVEFDTPTNLMANKHSQFYALVATHGEQHQQQQPTTTNVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2X0</accession>
    <name>A0A914I2X0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I2X0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6338.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6338.t2"/>
        <property type="gene ID" value="Gr19_v10_g6338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036964141" description="Importin subunit alpha" evidence="11">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6338.t2"/>
        </source>
    </evidence>
    <sequence length="494" mass="54133" checksum="DC065E116EAFA321" modified="2023-02-22" version="1">MKMILLMFNAVLLLPIIFAMPNPISLLNSETDSNATNTNIQLVNQAKSLDPNERFAAVSRICGLLWKDAKENEVAIAEFVSIGAVPVLVNCLKSTDDKLIVEAAWALQRIAYIDKSIAVVEAGAVPLLVKLLQSPNMEVCKRTAWTLSNIACHNVRESKIVEAGAVPPLVNLLQSSNMEVCKYTAWALANIANVKAQEVVEAGAVPPFVKLLETQNMEVCKYTAAALANIANFKAQEVVEAGAVPPLVKLLETQNMEVCKYTAWALANIANVKAHEVVEAGAVPPLVKLLETQNMDLCRQTAWALGNIAAVKAHEVVEAGAVPPLVKLLETQNMEVCKYTAWTLKNISAVKAREVVEAGALPPLVELLQSPNADVCTQASLAIGKIIEKIPNLNGCYIDVEHIHIMAKKVIELIEKFGGLRKIKQLKTKESEFILKMIEKIQSSKGCVVCFDKKIEIAFKPCWHACVCKECSRQISICPMCRQIISHKQRIYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3C8</accession>
    <name>A0A914I3C8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3C8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g645.t1">
        <property type="protein sequence ID" value="Gr19_v10_g645.t1"/>
        <property type="gene ID" value="Gr19_v10_g645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g645.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17971" checksum="C307E0604BF4C66E" modified="2023-02-22" version="1">MFTQTIHHSGRKRRTEQFGQKDTLPHFLCARQLLSLAYWSVFPSPKIRWSGRKRRTEQFGQKGGAGRAASKPFDFDNFEALRQLCSICPDQQILDGPNDCLTMAAKNRLHSNAIWFREEDQQQQHQKVSGTAKNAKKTTIRGGRNKRSVVLQEQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3E6</accession>
    <name>A0A914I3E6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914I3E6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7143.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7143.t1"/>
        <property type="gene ID" value="Gr19_v10_g7143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000074">
        <property type="entry name" value="Mutt/nudix family protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11383:SF3">
        <property type="entry name" value="NAD(P)H PYROPHOSPHATASE NUDT13, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11383">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="302"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7143.t1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52767" checksum="1F61808A01A1BD52" modified="2023-02-22" version="1">MQPTSKRKACPDPFTATYLCRNSVNLFEMMLEKRIAANSRGYFTISSALMSMVITRARNVTKSGNFRSSSSSSSSSSSDSSDRPKPTANKADKKARSWQKPDFVDRAQTFDYWTRCDDNVIEKEFQRGKLLLTVNKQPAVHSDAFIYNPTTSKYQMQSSPRLRLFDCQEIRQILNPYGLEVGTLNSALLHYYPSDGVQDADVDLRAIFGANIVLNEPPAESGISGQSQLEQLARDLGVRFMPMRQAMLTMDDPAQREMLAKFAVITRWYRLFVHCPRCAKILKMKASKASAKCAECEEDFYPNISPVAITLVRDESDRHALLVRHKGTAGQVYTCIAGFCSPGESIDQTVRREVAEEVGIECWDVRPLYGSQTWPLPTGSLMIPFVATANMDDEIQASISELEYAKWFSRENVAEALRRSESDPLLINLSRHLGASGKDPETRIQLRYIPPQGAIAHDIIKNWIQRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3H5</accession>
    <name>A0A914I3H5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3H5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6486.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6486.t1"/>
        <property type="gene ID" value="Gr19_v10_g6486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="219"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6486.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37839" checksum="ED490E2873542B17" modified="2023-02-22" version="1">MIDGLMDIRRDNRNSSNCTAHLSKRHLITNTNQMNDDSSPHIVGVKEWSMCKQSIKELLAPNFSTYYILNFYHKMEMPEFGLCALSPKELFWHEIEGNVSARHSDNVLVHQWTGTEDAQFWPGLMCDMDKPVVITLECAEEETQIKIMFSCGSKHSAFIFNLCPFKQDAYLVFFVPYQKFRDGHLSLLSPLHFLLEFIGRMRSSTAIGGNQQPDDVNACCVCQSVTEVVFLPCGHSSFCLKCSKKAAKDPRCPVCRLNIFERHVYRLSSPRCLTCPARFDCRRMDCMLLPCCCVVGCKQYTELAVQSGVDECPACGQQPVERIIKVFVQQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3T1</accession>
    <name>A0A914I3T1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Seipin</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3T1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7048.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7048.t1"/>
        <property type="gene ID" value="Gr19_v10_g7048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740">
        <property type="entry name" value="JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740:SF4">
        <property type="entry name" value="JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7048.t1"/>
        </source>
    </evidence>
    <sequence length="749" mass="84097" checksum="D418150B148628DA" modified="2023-02-22" version="1">MRKNPQTCEPCLSTTNTINNYQMLFSFCLRFLSGPLFYAWHSVRKQFSLAAIITLCIRLISLFMMALITPIVLRRMFASNFVELQQPLEFIFKTCSDELAGVCSFPEAQFSLEEEDIQLQPGYYYSFVLDIVLFDTMQNRQLSIVLASVMLKDERVKLLYQFHKSVPIFNAFTARSVISRLYTLTRNMFFWPLYLAGFFSSSGHELSELFSIHFPSYYLERESRPTRLVVVQLQNKFIQLSSAQLRVRTHLNILSAFVSEYPLLSYVLMFCACFSLFFSTFAIFHFVQWARRWTAPTNAIIDSTMDNDSLEEILDTTMFVSSSTPSVSGQFFVANNAISPTALAPQLLLPPCPGACGWRPTSALLLSDNLTSQTSGDGITTQFADGDRIAAMDEEAIIELIFAHCRPCPWGTRRWWHNSATNGGGGDSLCRPCETPLRTFDYLFLLFHVIVPFVLNSVAICYNADRMRQTRRLLLWTVCQLVCALLECSLAFIGALLIFRPFGELRTFGCSREGKLEEWYSMWNNPVLHYSRVLHCSSELVYPLYSLPFVIYALNLATLLIVRSLLHITIATFCNTSLPSAPFYAALWALPLLALAHAVLSGVLFALFPFIALLAALLHLVVHLSVRATHRTRSPSTASTAVSSPATTVGGMFRLLLSTAYHRGRPVPLWLPWLVHLALFAFALLSLLIAFGAPNSGQMAELVATLFGGTRSLLALTLCVLLPLPTLFFILTIRLTAPGSIALANRCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4H1</accession>
    <name>A0A914I4H1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4H1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7229.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7229.t1"/>
        <property type="gene ID" value="Gr19_v10_g7229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000002">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7229.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16916" checksum="E952ECC613BE7FFA" modified="2023-02-22" version="1">MAAMNRIKQELKDLEREPVATYTAGPVDNSNLLIWNASIQGPPDSPYEGGTFKLRIEFPKEYPFRPPHCTFTTRVYHPNVSNNGAICLDILKDKWAPALTVSKVLISICAFLCDPNATNPMNTEVGRVYRTNRHKFDATAREWTQKYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I555</accession>
    <name>A0A914I555_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I555"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7407.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7407.t1"/>
        <property type="gene ID" value="Gr19_v10_g7407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="102"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7407.t1"/>
        </source>
    </evidence>
    <sequence length="736" mass="86126" checksum="1825DC5CBF9DE896" modified="2023-02-22" version="1">MGREREHRSERKRDVEKDQSPADESSSGGRKRTKKEKNRSPSPPRSRSHTYSPSPRREISPKRRARSRSRSRDLPPSSRFGGGGYYGSRRFYDGRDNPNPSPCLGVFGMSLHTTERDLKHLFGRYGEVESVQVVYDRYSGRSRGFGFVYFTSTKDATRAKDHMVDAVIDGMKVRVDYSVTRGGGPYRHMQRSMSRSPVRNRSRSRSRSRSGSRMAEFVERELEQLLPIFEQLKLTQLMSADELSEFIDQCRAFEYKCAKRTKRAKDFLTYAHYMADQLEAIGKRRREVKFMHRYDEIERPLKRKCAFIHRICSHRFRKLEYHREEIAFLRRANMFKTCSQAYTRLLQIHGHLVSNHEEAARFEFFDNNHSADSARAILSIELRYVEFLHQRRQFLLHGKRKKKMKRNDQQRGEEAEESEQRCIADDDVLDLKLVRIVYELAMKNVEDPKEKTKLLRAFLRVARDCEDFSADLVQSLKENLQGLGENPSDFDEEEDQQRQVPDDELFAVDTEGNRTATNEEDGIRSIISQDEIGRRAMNNTTEEGGNSINMNKKKNNTSSVLDGFDPDDPELKQLLSKATLTENYDQRPLEDVLLVSVRQQKKQRKTDRASTAGPSWHSMPAAEMTDERRRDLEVVQMRDALDPAQHYKKPDREVLPKYFQVGHIIESKADFYAGRVPKRQRKRTMVEELMQDTEMLARNKRRFTAIVRRREAESRGAFQRHGALPKWSKRKNAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5T4</accession>
    <name>A0A914I5T4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5T4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7040.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7040.t1"/>
        <property type="gene ID" value="Gr19_v10_g7040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037801180" evidence="3">
        <location>
            <begin position="29"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7040.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29582" checksum="98A676C41D2D3C13" modified="2023-02-22" version="1">MLLTHRIHFVLFTSIDLIGFFATHQVQAVSAEQQLFKNEDAFGVQYLSLLKQQLRSRPRHIEQVQKKTSHGTELDRQRVGNVVIIKKRKAEWDPEQFGANRMLLKQEPGRETDDDVDDQRRQQRVQPHHNTHRYQQMAMEEELRREQAMSQSFLLLVAFCAVLFSLMLSILGFATFYYVSIIHRGGFACWATTAGPMGHHLQELAETGGQSSKECTTVVTMGEDTVATTTTTTVHRPGDKKSKKSSRNDLRRKSSPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5Y6</accession>
    <name>A0A914I5Y6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (cytosine(34)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.203</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the jagunal family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.203" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914I5Y6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7816.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7816.t1"/>
        <property type="gene ID" value="Gr19_v10_g7816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009787">
        <property type="entry name" value="Jagunal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07086">
        <property type="entry name" value="Jagunal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="19">
        <location>
            <begin position="60"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="949"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="152"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7816.t1"/>
        </source>
    </evidence>
    <sequence length="1044" mass="118124" checksum="7151D25ED89B41B1" modified="2023-02-22" version="1">MGDSFPLEIESEHRRKAVASSKQRPPAKGIRQNYELNRFERCNDALFEFFKQQGIVPDSEWDHGVSLKEIALPITSSATSSNKLLLLKQMKRCPLKTKMARATIRRHPILKEFHQFLVNETELGNISRQEACSMVPPLLLDVQPHHRVLDACAAPGSKTMQIIELMHENCSNPEGLVVANDSDYKRCYLLVRQTLKRMPTANVVVVSHDASQLPTVLDAKKRPVLFDRILCDLICSGDGTLRKNPELWKSWDPLKGVNLHKLQLQIALRCLELLAVGGLMVYSTCSLNPIEDEAVIAQLLRKFNGLVELVDVSDQLPELKRASGMSKWKVFDKEMKEVHSLDDLRVDVKRYFKPSMFPPTPAEASQMHLERCFRILPHSQDSGGFFVALLRKTEVKRSADQQQFVEDTNAETTDREPISSNLKSGPPKRARLSNKEDPFIFLGKNDENNERFISELNTHFGISPDKFPHSNLLVRSHNTERKKEIYFVNDAVRDFLMFNEKRFRIVNAGVGVLKRIASEKVAHCPYRLKQDGLRVLSPFISKKIVDIPVCALVKILKGRPKEDGSSQFLPFGELGANEALFKDMATGSLLLRFRSESLGTKILCTWKGTNSISAFVSREEKIHILSLLDERRGGPRAIGSDGSDFKHRQKIAASIKLSIQCKFYLKMLFLLHLSILLPMWVKVGGELVFKEFGLLEQPDLWRQLDLPAAYPWEYVWCLSFIPMLFALLSFNRNKAILLKLHYYGQFVFGLMPACIGIGSQFPELVDFLRHGESSRTPTFKGHFPMVVLWYLFFIAIFQVHGFSMYFSYNLYGAWHRKPPKGAQLTENNGKDVKTDAMNPIYSSTASSSSSAARGALPKRVTNFPKIPSGIAVLWLITVPFGDGLKCLDCTGRNCMGNFCNGDYCLMSHYAPRWGTMVWGEPTVVKGCLSGRMIRRGLRSHCEAADEVGKDDLRVPPPHSAHHSAERRRVEAAIPQKALPGELRYGSGRLRRRITVFDGRKEKERAPGIHLPEWNLKKAADATITTRPPTFLAFSGQNEFPFSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I652</accession>
    <name>A0A914I652_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I652"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7250.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7250.t1"/>
        <property type="gene ID" value="Gr19_v10_g7250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF326">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER SNF-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7250.t1"/>
        </source>
    </evidence>
    <sequence length="430" mass="46970" checksum="5114F04AA97A7FBC" modified="2023-02-22" version="1">MALKEKAVVERAQWGSGWQFILVCIGYAVGLGNLWRFPSLAYEHGGGAFLVPYLTCSFVVGFPLLFLEMSLGQFSQCGPAVVHGRIRPFFQGVGWCMAAISLMVSIYYNVIVGWVLIYIWIIVTGHSAEWAACTNRFNTIYCQSSLEDTRCASELASAGATNSSGWAFFFNGTCFHGTDKEAQAARKAQFAILPAVSPAEEFFELYVLEKSDRMDDGPGGLNWKAAAALCAAWIITALVLVKGVKMMGKVSYFTATVPYAIIVVLFIRGITLDGAQLGLDFYLFKPDFSVILDPVTWRAAATHVCYSLSVGFGGILSLSSFNPRSHNCFKDALIITAADGFMSIFGGTAVFCVLGFMAKQLGLEIDQVVQSGTGLAFIAYPEAMSRMPMPWLWSFLFFVMLFILGISSQFGLAEVMCTAVCVFLLIMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I799</accession>
    <name>A0A914I799_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I799"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8159.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8159.t1"/>
        <property type="gene ID" value="Gr19_v10_g8159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000365">
        <property type="entry name" value="Muscarinic acetylcholine receptor gar-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF185">
        <property type="entry name" value="DOPAMINE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="51"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="486"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8159.t1"/>
        </source>
    </evidence>
    <sequence length="881" mass="98183" checksum="3F246883668EEC1E" modified="2023-02-22" version="1">MLQDRKGSRQIRLLGHLQSVEATSLPQCPHLIMQVFGWFITSLLSLETIVGNSMVLLAYRLERSISKQLNNRFIVSLAISDLIIGIEGIPFFTVYVINGDRWPLGAVACETWLFLDYTLCLVSILTVLLITADRYLSVCHTAYYLKWQTPMKIQLLITGSWLLPALIFGVMIFGWPWIGGKEERIQATSNGECYAPFLANPYVNMGMYLAYYWTTLVAMLILYKGIHKAAKKLEKRSRAREHRHIALLLTQRLGTQVGVGLMLHAKRYHEEAKNDEQCKQQLRCEAKDSGYITVNTLSTTDSGDRRRSSFTTLAKAVQSTQRLARFRRYGATFSFRSKSAAAAAAEMKRPPQTEKAAKAKADKAENCPERVTEQNRPGGCPLMANIETVKENPTEDEEDEGNCSLAFEDDDEEDLEQKEACAFKSDFGDGDETFDTVAIISLSTGAFNDESLSSVLHFNPSAMASPLADPSASDTTSQIIANRKMAGESVDTNAGRSKSIARNASSTNSERRHKKDEKMKCAAGSLKERRQHRGRAKSTTETPTNKMCPVPLPPQPSPIASNTNNTMDSGPSAEICPRRWEWPPTERRGVENADKTPTKTKGENAELPAKLRMPSQPQVDPLNVSSDDSRRTAVLAVSQRTSRPPSRRPSEQQRQEVANAMSEEDNGFSERNGGESSVENRPDLLYGLPSFLHSSRSYSTMSSISSQDTSRRPSFLQTHGQVPTLTVTRGSIWGSDGDGSRRATGGEAAEECPNVRAAHLSFAEGGGVDERKPSRILHSVFAPISALHRRRKRTKAERRALKAFRTITFIVGLFAILWSPYYVVATIYGFCRGECIPSVLYNVSYYMCYLNSSLNPFAYALANRQFRLAFVRILRGNLRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8U8</accession>
    <name>A0A914I8U8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xrn1 helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8U8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g835.t1">
        <property type="protein sequence ID" value="Gr19_v10_g835.t1"/>
        <property type="gene ID" value="Gr19_v10_g835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g835.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23189" checksum="B1FED8622C7A16D4" modified="2023-02-22" version="1">MEKESHSKIDRILLHVMTKISGRCALCSGRRVGSEFPGPKSERSASGERHTTKFACGRGGCASWKWFFPYHHAHFAFDFELISNFEPILTPPQAIQPTGAIDDVFPATSRCFQGVALLPFVEEKHRGIRLGLTDFLLAQNTLFSLVHEVHSEGSRLKQEDEKKTTAATEMDVEATDGEDGGKMKQQIGETITDRPKNGTISITGVKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9K8</accession>
    <name>A0A914I9K8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9K8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7961.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7961.t1"/>
        <property type="gene ID" value="Gr19_v10_g7961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7961.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39163" checksum="D15D83D14F01AEE0" modified="2023-02-22" version="1">MLTESTNGGITAADQDPSGELALLRAKIAQLECQQSMNSSTSSSDEVGGADTLFNQNEIGEEMKMELNLAKVKQLQEEMKEELKDMKHYKEDMKQYKEDMKQYKEDMKQNKEDMKQYNEDMKQNKEDMKQYKEGMKQYKEVIDTKLEQMEEWKMIVKNQMEELKQQREMDALKQQQNQKEANDKIGCLNKDQQKQFLLMQSDRKAIRERLNRLKQRQTANSDQQQKTDQQPQRSAVIGEKFSNLTKNQQCNERHEEQLNNFLEQYSGGCPVTGANSAIPTAPLIRHNLASFTADDDELIKRVDFAYAEAYSAHFSHNLPILDDRYGTMGVDPQQLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Q0</accession>
    <name>A0A914I9Q0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9Q0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g859.t1">
        <property type="protein sequence ID" value="Gr19_v10_g859.t1"/>
        <property type="gene ID" value="Gr19_v10_g859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g859.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7798" checksum="0878664731D62F6E" modified="2023-02-22" version="1">MDNRLIDKILFENVATRRFFMGTFPSDCLPECTRFPCSLIVNLDRAGRPGSHWPDEFVYAFVTNKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9R2</accession>
    <name>A0A914I9R2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">lysoplasmalogenase</fullName>
            <ecNumber evidence="6">3.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:22544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:73359"/>
            <dbReference type="ChEBI" id="CHEBI:77287"/>
            <dbReference type="EC" id="3.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:16905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:73359"/>
            <dbReference type="ChEBI" id="CHEBI:77288"/>
            <dbReference type="ChEBI" id="CHEBI:143890"/>
            <dbReference type="EC" id="3.3.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.2" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914I9R2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8203.t5">
        <property type="protein sequence ID" value="Gr19_v10_g8203.t5"/>
        <property type="gene ID" value="Gr19_v10_g8203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047408">
        <property type="term" value="F:alkenylglycerophosphocholine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="TMEM86B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885:SF6">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038033681" description="lysoplasmalogenase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8203.t5"/>
        </source>
    </evidence>
    <sequence length="416" mass="47134" checksum="3F572BFFF446376B" modified="2023-02-22" version="1">MHKLVIYVLLIAFFYEQTGGFNEQLGFQYSFLKALPILCLALFVNFGWYSVKRTHRQRYLLVASLLAAAGGDFVISIRENIEPSFALSALFFAAAHILYMAFLLPFLRHPFVPLTLCCAAYVVVMNYAFLLPHVVTHPFSTLVLMTYSVVLTTAFIISGSLMFVGTHFQPPLQKSNVMHFVGFCFFYLSDTLLLLEHADVKFPPCYKEELILSTYYMSQYLIDLRESKCQLYLILTSGDKHSPFGTGSEGCWNCWTIGLALQKRRRISRLHFEHRPIFSGTSTAFNNEGKTGPCQNIVDYVPIANVRHLPPLSLCVLVAVLTSLCTQLAVFLLSCLWAALRKCFDRRRRNGTVVGSAASINRHQSDKLLCCTTTLTPTRKRRRGEGPKTTEGEADRAKTADCCGDKTWRRIIQVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Y3</accession>
    <name>A0A914I9Y3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9Y3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8652.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8652.t1"/>
        <property type="gene ID" value="Gr19_v10_g8652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF369">
        <property type="entry name" value="FI18813P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="246"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="381"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8652.t1"/>
        </source>
    </evidence>
    <sequence length="534" mass="58157" checksum="D56BBECBB7382C74" modified="2023-02-22" version="1">MDLPGGAGGRAPFPPPSSLKSNSPQLPNYLIERVRREAMDDERDGKAAAFSSRPNGTISFGSQMLAIGAGFCMFIILLALFAAVQHRKRRRSSGAVGSFRSPLIHKRSYGGSSTGGRLSQAIPPPPAPQYLRCSNQSLRKCSSPGGSDYSLSSSYSSSAASAHSLSPMSPYGHASGGGGYQHSPFSGLNFIPYGASEGTERHINTTTITTSNNNNNNNSCRKRHSTEAAIMGVTGVPDLELGPDGARGSVSLQLAYDSSNLALQITVLACNGLPKFVGTSTPLNPYIKLRLLPEGQHRVKTRILRDTREPIFDEAFTMYGLSGETIRNCRLHLAALAFDRYNGDNVLGEAVYDLAEFCADGFEQKYVSLKWQGRNPFEGQKRGKALVRMGFDRKSRAVKFSLLQMSDLPRDASLGLLDPYAKVYALINGQKRVAKQKTRVMRRTLSPLFGAEDWLEFVLPDNVGLDADGVPRSLSFNVVLFNHDGVKRNEPIGQFTVDAASELFNGTFKAHQEQNGLTAAEDKERAEWHVILPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAE5</accession>
    <name>A0A914IAE5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914IAE5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8161.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8161.t1"/>
        <property type="gene ID" value="Gr19_v10_g8161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8161.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8098" checksum="352DBC4B47C5C16C" modified="2023-02-22" version="1">MVWSVGTQLILCNPVCAQAYAFFAYRFFEDRIWEEERYLIEFFGQRYIAYQRRVPSGIPYIKGYAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB92</accession>
    <name>A0A914IB92_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB92"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g830.t1">
        <property type="protein sequence ID" value="Gr19_v10_g830.t1"/>
        <property type="gene ID" value="Gr19_v10_g830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="557"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g830.t1"/>
        </source>
    </evidence>
    <sequence length="864" mass="97861" checksum="0F2289C22A298BC5" modified="2023-02-22" version="1">MAQINLTQNGGGGVVENEDVLPMQNIGGIGEDVIGADNGIMDLDSSIAYYTPLSSPQSAANSTPIPIMQCSQEERPNSRQVVETGLETGGDRAPTAPDCTTNPQNGPAGQEGTPATAPARRVLRSWSENDKICLVVTRKSCLNSCVCSWKKFHVDHWIPLWTEESVDSLRTNLTLCSQYSNLLNRTTISYDIDNWSYRMNASNLRCGLSLRPEQSPVSQEAEPANPQDGVSEAVEEPVIPSIPGAVEEARPIQVELENGTKGNEKKSKYDEFRLIFVHVFNVISREKSAKRKALLIPSRISDEEWKWCDRLFRRYFKSRRGNTTLLRVNQVLYAIGKALEKREAARRRGHMESRQQWYRDQRREISRLRCHIGWITDELNRRKKGEAPTRVQKRNFHAIRHRYAENGKAIRTQHQLERRCESLKGQLALAIDRVRLRQTDEDRKRIRFAPVKRIIEGKPMPSVLDSVECVRSYWQKIVGEPKGFIKTANMQEWQNKLPQIPGQNLTESTHESEYEEWLKVVAKVRPRKAPGPDGIPNLLWKKITPANRWLFEWVMQIREKRCRFPKWLTKGRIVLLPKKPNAQEPGDLRPIACLNTCYKLMTGLMTRWLSRHLNTNGLLPVTQRALVAGEWGCTHSQVLDRTITADARSHGRQLAIAWLDYSKAFDSVPHSYIHHILKVLNVDERLRTAISDLMAGWEVIYELRTKEGTKSSVPLKVQRGVLQGDTLSPLLFCTALIPLTSTIDVKVPKYVTSTLSVGGNTDRAMKMNNIFYMDDCKLFCPNRKDLDEAITLVKEESLAIGLALNASKCAIAQSGPEARVAAGILDIPVIGTGETYKYLGVEQLISPNEVVAWERTLIWPLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICB5</accession>
    <name>A0A914ICB5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GDP-fucose transporter 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8616.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8616.t1"/>
        <property type="gene ID" value="Gr19_v10_g8616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8616.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39241" checksum="10FEB54701B96D02" modified="2023-02-22" version="1">MPPPPPPSTGQQQQQSPKSLVQRYSEIVAAVFAYWTCSISLVFLNKHLLSSPDLKLNAPLFVTWYQCIISFVLCLLCSRLSKWVPRLISFPDMPIDLRLSREVLPLSLVFVAMITFNNFVQCGLFLPYPGPDHLQTGIALLLLIVAGFLLGVNQEDVAGTLSINGVIYGVLASLFVALNAIFTKKTLPTVGDSIWRMTMYNNLNACLLFPPLMLLAGEFGEVPYSPHIVKFNFWAMMSLGGFFGFIMGYVTGWQIQVTSALTHNISGTAKAAAQTVIAVAWWREFKPILWWLSNAVVLVGSAAYTWVQKKDMDRKFYEAKEAGAKYEEELQKKLDTVQQSSEANDGKPNEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICG0</accession>
    <name>A0A914ICG0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="8">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914ICG0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9552.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9552.t2"/>
        <property type="gene ID" value="Gr19_v10_g9552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000002">
        <property type="entry name" value="Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="9">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9552.t2"/>
        </source>
    </evidence>
    <sequence length="520" mass="56595" checksum="D09C5CABD2D1D56E" modified="2023-02-22" version="1">MLRILQENNVIFRCFSTSNRLNIAKICINAAEAVKDIPNGATILFGGFGPCGIPEHLISALADRGVNQLTCISNSPGTDDYGLGLLLKQKQVHKMVSSYVGENDEFARQYLGGELELEFSPQGTLAERIRAGGAGIPAFYTPTGYATLIQEGGAPAKYSITENGKIEISSKPKETRTFGSVHYVLEHAIRADYAIIKAWKADNVGNLVFRGTAANFNSPMCKAAKCTIVEVEELVEAGELEPEHIHVPSIYTHRILYGGKNYRKPFEKLVIRDEYGNTTVDKQLVNNKKDDNGNGANVREVIARRAAIEFEDGMYVNLGIGIPTLCPSYINDKSVKVRIHAENGLLGVGQYPIKGEEDPDCVNAGKESVTYSRGASVFGSDESFAMVRGGHIDLTMLGSLQVSMKGDLANWMIPGKMLKGMGGAMDLVSAPDARVVVLMEHTAKNGNHKILENCTLPLTGKEVVKRIITEMAVFDVSPTEGLTLIELHQDYNVDDVKKATGCTFKISNGLRAMKQAINSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID47</accession>
    <name>A0A914ID47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8783.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8783.t2"/>
        <property type="gene ID" value="Gr19_v10_g8783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8783.t2"/>
        </source>
    </evidence>
    <sequence length="133" mass="14658" checksum="6C9E8577928B1512" modified="2023-02-22" version="1">MADCFLWHSLMHSLRNARSRSDPKGAKVNGNAAGAAAAPCHASTSEVTAKRPPPPAHPTELPKDVKSEDGAAVFFPVLLSDFRSDLHQLQDSLRRDLEELETLRLQNAVLRQQLAERDRIIASLQQQLRGQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDJ3</accession>
    <name>A0A914IDJ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KASH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDJ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8898.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8898.t1"/>
        <property type="gene ID" value="Gr19_v10_g8898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8898.t1"/>
        </source>
    </evidence>
    <sequence length="802" mass="90793" checksum="17071276BE7B81D8" modified="2023-02-22" version="1">MNGSPANFSKNEKAFVLMGAQSEVLVEDDQLLVEERCSALWNAIKDAAVLDGAELSNAFLAQLQSESDHLDEQLRLCSVWTALEELKRKKQRNTGDFGEFHRHQFGANRTIDTFRRWLQQKEAQLNLIKQRIPPAHNSETSLRELEQEQTALQQNIETEGRAKHQQLCSSHSNRQNGVDLSISGECERLEHRYLALWLASLESLELIHHFSALLVKRCSEALLDSELETEEQKDKEEEREGPNPKRRKTSEEMKQYMENNSNNAEGTKCHQDDHPQQQQLTDIGYSSGENMSVHDGGTNTTVSEETPEDEGRTGKSVGDGQQNRPDERDNFTMMDNSELEKSFYRMVPLDEFGQTDLDTDEGNWPRSSYWAQRFLEEVEKGCCGGKGGGGVIDLTDSLIVHVDGPESREKLNDFEEVMDLIDGRRRVDPFIEDECESQSTDDWNVGGRGRVHPPNSMKPRKRALAGALPAIVLDKTVPVQKTETDKSRQSPRGLRRKCAARLRKLSLTMTSTMELELPKRKRCVRSETELLALVDKSLGGVDSASFLLAEMNNTFAALSGLCQQLEQKMCRSVVGGKSSHKMDILKEGMEAELVLCHERMNALETTCNNLALLLGGHLNGGEMPKICSMETDERGDYLAQFSNECSRIRKELKKLKSRLDRKLAFCPSTQMMPPNSKSAEEMESAGETWKNHSDRRIERAVQVSALDSVRPVQKNSFWRSYLLLCMIGLIASFGTLFAERRPFELRAIVCLQQNLLILFCNTVTSHYRYYSTIYPIPSPLPSLHNQINQSAIRPSLLIYKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEF2</accession>
    <name>A0A914IEF2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEF2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9857.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9857.t1"/>
        <property type="gene ID" value="Gr19_v10_g9857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9857.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22893" checksum="284CCBE8308AA217" modified="2023-02-22" version="1">MIGRFVRNLLNGQHIICKVQQVQAVHVTFLHQCAKNNVCPAAVLSCGARMASSSSSSNRPSHRSELLDAYRNNRAANLQLADLGKDAVAFALDPHGSRFIEQKLERANPTEKAQFVDALRGHVLTLSQQVYGSHVIEKALKSVDKASQIEIINELLDNVPTLVTDKYGNYVIEHVIEHGLPEDRARIVRRLHGKVTICPSMNTVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEP7</accession>
    <name>A0A914IEP7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9926.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9926.t1"/>
        <property type="gene ID" value="Gr19_v10_g9926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="86"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="260"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9926.t1"/>
        </source>
    </evidence>
    <sequence length="510" mass="56872" checksum="E1D194A9553AB8B4" modified="2023-02-22" version="1">MLEYSSAVASASILPQIGTNHREQLPAKRTNSFSEGGSFSAMISAVNDGRVGVYQTAQDSPGAADQQQMQQPLDLFMDFTRPDGQRTRPLLVDGKRLYVDEHYISVWSPVLRSWCIECPDRELILANVQYDHVLELLLAIHPTYKEVDEQTVHILLPLAFDYQMDGLLHRCECFLVANKLPFLEKVWLADRFQLNRLLSLLLRELRPSVHKLDLSGPRYAGLSDRVKVLLLERMHGSPAPEELPEPPMDMEHLLSASDLNFATVKAKTGRAYHVNPYYVAAWSSLFQDRLCNGSSGDGVPNEDDLIYCPCSSEELKYFLMAIYPPQLRVTECNIAPVLMAACKLESQGLLRKCATILLSPHTQLSVFVRLSLLDRCRLQELLAQCLQMVHRPENLVEMSQQQTYECLSIRAKAEMMDRFASLVQLQGGSNWPASISGQPASSSAAIHLCSRCKTQSACAELTWQCPQCKTYTSAASVEPSGRHSVVSSQQKQQQMGNGIGSGGIGRVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF53</accession>
    <name>A0A914IF53_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IF53"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9321.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9321.t1"/>
        <property type="gene ID" value="Gr19_v10_g9321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9321.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="28193" checksum="BCAB9C50730B1E96" modified="2023-02-22" version="1">MKAYGGVVKPPGFYKIVLRDRWRSVQSALCADVFEYVMRDIIQKDNAVVYIKRFFNYEAESNLEEFKTIYIHMFPLDKNKKLIHSSSEPKFFLQNVMKKTNWKNCNEEFYLAFYHFAERDFKISKLLSRWVSLSQNAKLSDEEAFLLKAYLRDVTEKLVKFFTNGLEMKTRELNILFNYGNSLLKCQNEENSKMLVNLANVGTASKELPKTDKTHFKKVQKATGGTGVFHSVLLPHLRNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IG62</accession>
    <name>A0A914IG62_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IG62"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9605.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9605.t1"/>
        <property type="gene ID" value="Gr19_v10_g9605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9605.t1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41917" checksum="CC144F975F99F81F" modified="2023-02-22" version="1">MELLFFNPDEYERLYNCSSYEIDQVPLSKRQNIPFGVAFLSISIICEVLYVPCMIAIRKHMDSTCFKFMFYIAIADMLCLLVCGIVTGYLAIIGAVFCTAPTFIYISGAFALALWVTETTAEMFLAFNRCVELSSSRLADFLFGGKRIYLWMVMATLYGMYIVLFTKPLIFNGIYITWFQNPHVGYIDSFEDTYRNSLQSIQNLIVTSVLPGIYLLFALILFVKGRKISTGAGPDASSVNQKSIFIQILLISCVNAIAAAIYLSMNLVPLSKLLILVGQFCWIMDHGIPPIIYLLFNKTVRRDVLVMFVRPIGMVFPCVTLPSGDKTSIIRTLETNRVTATSKSIRTIMSQANRMKPLATIEPCATKWIQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGH4</accession>
    <name>A0A914IGH4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGH4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9661.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9661.t2"/>
        <property type="gene ID" value="Gr19_v10_g9661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9661.t2"/>
        </source>
    </evidence>
    <sequence length="356" mass="41684" checksum="55557D971435ED75" modified="2023-02-22" version="1">MTVKRRYYKEFKETPSKNVNLRNKEKLKQHKGKKNRQKKSSAINANGYKNGQFERIGKNIKLYRRKNIKKKVAHQFNVNDDNFNDKNFKLIMQEDKLNQSYVAKKTPRGPPKHPERDKRWRKRRYKNHNADDIGGGERPSLKLGQRRGSRYLYVNKKNKMRARTRPREREAVTERAAAERKWEQLKDRLEVERKIARAQRKRRRSDYTESERAAATANRRRNSVLIREGGRRQRTINQQQQQHTFSSLADSDDDNDSDELAWGREADDERINDGMARDEKAQRNAAAAAAIWRRRDRDSLENSTERRMCSSATRSLLTDAVSRPRFDGVHAVAAFFFIRVRSSATSSPSAAPAVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPB2</accession>
    <name>A0A914GPB2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPB2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10095.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10095.t2"/>
        <property type="gene ID" value="Gr19_v10_g10095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10095.t2"/>
        </source>
    </evidence>
    <sequence length="804" mass="88559" checksum="1BF0FD6D910666BA" modified="2023-02-22" version="1">MENVTMIRVSRAIDGNGAQIVKLSGEQLPIPQEPIPNKVIGFQGIVASYVDQTVMEFLQRIRRLFDSSETNMIITTSADQSPEDNADASSRQALAKWLLTAREDGHPKILLCGHYSGGMDGLKGTPKLTSVWAQKNAEADLQNKLDEQLVRIMVRQNVSAYFFDDKDLQELVKTAFPGQKIYSRCHFTQSVIPPPFNFPILMMEKPFTVKNFVYPVEQFGKRLQTVCYDVQIPLPDPNSAPSDLFGHLIAQNRLPLPFQKEVKAAFEKFVRDETRKFDAELATRRIEFALNGGGGGTSDDGEANGDANKAIFGGNSTEFDAQTIANTAVGGPLFEEQFQHVMRHASAAQLSLLVREESRMAEEMRALVRARNFEVERIKRACEDTLANSVGATEFDKHSYELSMLNEKLRQVSINYSNQIEALNERQRDEYRQLVRALYTNETDGVQQKESTLASSSSCFGFTTTAAAASPPVRPQPPSSSRLFKKSLSYDSKIAQHVTAALGTGGNVHQQTNQCRSESFTIYIGAQLKTMHNARILTSDRLVDLMMLNNDASGGIGIGIMTSAASTVEGMELERADNIGTAGMTATTLCHSQRLQLLMNLYRRDLACAILIVGGCDPLWHVKERTNFAQLCEQSVELHFESLERQLMKIEQDVRSANRDRRAACQRRRQQQRCRDENGGGGGGGGGSATTAAVSTASPSASMPLLLTAYDDDLVMHTAHGQQNGDNFGDENSLRPGDVYVTCHSNLSAVQVLCCSSCFPRGRRPFVGRAGHFLTAPVHRRVAQCHPIGAPFRCPSHHAAIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPH0</accession>
    <name>A0A914GPH0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914GPH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10221.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10221.t1"/>
        <property type="gene ID" value="Gr19_v10_g10221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037458577" description="mitogen-activated protein kinase kinase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="443"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10221.t1"/>
        </source>
    </evidence>
    <sequence length="772" mass="86285" checksum="DF80DC182A285226" modified="2023-02-22" version="1">MLEFIYSIKIIALFIFARYGHCSSDGENNGRECNICLSKNINEDELQTLPCRHVFHEKCITPWASDHNTCPTCRAVFPRHVGSIVLLIKDLLVKANQMQIETLANAQHYRNWALASAQTMKYAQKSDEFMQALETAQKIRNDLLRRLMEADAVLNEALQDSDRTLNEAAEHAQRVHDEATVHVEQRRASLQSAKSQALPNAHLLAALENAEHFLIETTANAQNLMSSNSDSERIENESREHADFIYSEAKANVLSTPAEALPNAQGLLDYAERTSERIQSETTAKAARIRNETMAISERIRTETLANAQRIKKEFENALRLANKSENGRNFVVDATVDSGWAAEERELYIDDITLMFFDSLMVVLNAAFPGQQIQYDFFEYEDDDGERLRVRTDEELATFLADLAPNHVHGQPLRIRLKTSRVQRLQSVDFEGDEQPFEPEELRFIERLSDGQFGSVYKSLDTRNDRLIAVKCIAVDGASGTRQGLLNEIAILKRCAHPNIVQFHAALFVDNQLLICMELMDALSLDRYGQLTPPVLGAISVAVIDGLKYLWELHIMHRDIKPSNFLVNSAGQVKLADFGVSKQMAQSVAWSYVGTKVYMAPERLGGDVYSVASDVWSFGISLAEMALGRFPFGPSFASSASTMPNLFIIEALISRPEAIATVISQPELSAVGYGFDELLAGCLALNPKERLGPEKIYHHNFLTSHRPTDQNAVAKFIAQRGKPSKILHCIKLGFSLSNAAIFALFGREKLVGYLNAGNDTKGLDLRVTLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPS3</accession>
    <name>A0A914GPS3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPS3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10039.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10039.t1"/>
        <property type="gene ID" value="Gr19_v10_g10039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036918660" evidence="2">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10039.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="34984" checksum="18DF21DC55560DF3" modified="2023-02-22" version="1">MKSISAAFGFGFFAMLAVLPRYSSGLKCKFGRASRLGSTAVRNVTCDAGSEYCWAANCTAWDQPGNVIMNWGCVNSSDESIKKCGYMQEMRMESLKSDNVTCECFIGARGLDWTNVQHTLLPRLGGLKCKEGKLNAAGNLCKRTEHFQRIWGCSEHTSCSAVTAKVGKLANSTMQCECMFGEKGVDFSNRNFTILPKTTTTTTDKPTTTTDKPTTTTDYGNRAVTPNNAMGSSAIISTTNTMGSASTNGTEYTPPLRCWLKRACKFSPTIKSAKLGGRFKVPDCVGAMAKLDATTDDRILQALGNEFVGRKDGIFLREFVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPZ1</accession>
    <name>A0A914GPZ1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Guanylate cyclase</fullName>
            <ecNumber evidence="4 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4 16"/>
    <dbReference type="AlphaFoldDB" id="A0A914GPZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10267.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10267.t1"/>
        <property type="gene ID" value="Gr19_v10_g10267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000050">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF503">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036803137" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="26"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="505"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="22">
        <location>
            <begin position="959"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="688"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="896"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="701"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10267.t1"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130571" checksum="F432E7A267231D4D" modified="2023-02-22" version="1">MLLPPSPPYLFELFLLLFIISSLLPLSVVPNIVKIAHLQPNNPAIMHEPQVLKLCAANLKEKKVLPDAISLEIITMESCSRFSGVEHAAYLHYLRNSSVYFGPGCNNEMLVIGRLVSRWNVPIIAHLSGDDALSDRSVFDTLGSVALTSATEMARATLTFLQLYGWKQVGLVKASVNFDRLSLHSLKGYLKDSQIEVNVEIELDPFMTPDEIIATGKLKQLRNRARIIIVEMGLDLHTSRSFMVAIARSQMKNPAEYVYIIPWLAHMHDHYPWEASNIDKLETRMAFDDTIVITAHGYDKKFIEEFELGFSKVTGVISSHYATLSYMSLYDALYLYGLALRDAYEETKNESIYVDGMFLWRKMIARQFIGATGQVLMNNKAVRVPSYATYLTKNGTMRIVVELEARLGDKLKCALSDNDCSEHVAHEVNSHYWITYDGQLPVDMPKCGFDGNLCDYSTLYIVLGVVLFFAIIVPLGYLLYAKEKQRMLYDMTWRIPREQVKLLEAKNLRSRSSGSFGKSMTSATDSFSVGSETANSRLSAKQAMANGVRCSYKRFQQTRNLSFNKEELSHLKELKMMEFENLNKFYGISFNQQNELIVLWILCQRGSLEDVVFNDELKISRNFQVSFAKDIVKGLYFLHNSPIKYHGFLCLQNCLVDSNWNVKLTNFVTEQIVGDKLRHNELKYMTESRLKAHKKAKKPTVNKDEEKKTTAGRREDREEREKDRDREREKRRRNREKERSGADSSEDSRSVTDEELEQSKKIYEKSHLKKYIQQAPEIIREFISTKHLPPGSQAADVYSLGMVLYQILFKLEPFYERNMQPKKIMERVALANEDEQIIRPAFPKQQISATEEAYNFQLLSALEACWLEIPEMRPNIKRMKTMVNANLKSTGSGSLVDQMMKMMEDYTTNLEQLVKERTQLLEEAQQQADRLLKNMLPQSIAEDLKAGRPVVPQYYSNSTVLFSDIRGFTRIASTSTPIQVVSFLNDLFSGFDAIIAKHDAYKVETIGDAYMIVSGVPRENGNAHVQHIAEIALKMRMFVTNFKLVHKPEEIMMVRIGFHSGPVAAGVVGLAAPRYCLFGDTVNMASRMESTGMANKIQISENSYNLLKCFYAQFVVVERGKVDIKGKGECTTYFLEGKENRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR98</accession>
    <name>A0A914GR98_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GR98"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10568.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10568.t1"/>
        <property type="gene ID" value="Gr19_v10_g10568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10568.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15294" checksum="9BDC29F9FCA3948C" modified="2023-02-22" version="1">MTKQQQQQQQKQQVQISQAVCEAYPFLCVLTRTKSMRKRRQMLKSANSQQLLALAEICLNIVRARFKLTTRQKSRMMPYADFIRRLSRARSERGARQLLIQKGSGFALQLFPSLLTPIILELSRILFSHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSG7</accession>
    <name>A0A914GSG7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSG7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10957.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10957.t2"/>
        <property type="gene ID" value="Gr19_v10_g10957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10957.t2"/>
        </source>
    </evidence>
    <sequence length="262" mass="28949" checksum="65ECDB1D8C0E159C" modified="2023-02-22" version="1">MLLRSTTRTQTGFDATPYLPQSQSTRWTGGTTNASSQFQVQQPSSLIKYHLPGSAPHYGGAMPYQQAPRTHGCRVENAAKASFKPIALKQGSFWVREKMRALLLLTLAFSCILKNSYCISYEDLINNKEAMDLVKENYDFRKNTLFAVDDLLQKLNNIKLEMCTRTLQRYVKKMREDGGGTPNFEASASGNPGSSIPNEASVFQEFLKEAGGGTSNFQASGNPGSSIPYEASVIQNFAKAFGIEPPNPYDGTLYSIYQNPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSP6</accession>
    <name>A0A914GSP6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Coatomer WD associated region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSP6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10931.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10931.t1"/>
        <property type="gene ID" value="Gr19_v10_g10931"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6886.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6886.t1"/>
        <property type="gene ID" value="Gr19_v10_g6886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000559">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="317"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="13">
        <location>
            <begin position="592"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10931.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6886.t1"/>
        </source>
    </evidence>
    <sequence length="838" mass="95912" checksum="2B9D3175499FDA4C" modified="2023-02-22" version="1">MALLKKFDSKSARVKGISFHSTRPWVLASLHSGVIQLWDYRMCVLIDKFEEHDGPIRGCDFHSQQPIFVSGGDDYKIKVWNYKQRKCIFTLLGHLDYIRTTFFHKQHPWIISASDDQTVRIWNWQARNCIAILTGHNHYVMCAQFHLTADLVASASLDQTVRVWDISGLRKNSAQTELFGQPNVVVKHVLEGHDRGVNWVSFHPSMPLLVSGADDRQVKLWRYNESKAWEVDSCRGHYNNVSCVIFHPKAELILSNSEDKSIRNFRHENDRFWVLASHPSLNIFAAGHDNGMMVFKTERERPPHCVHDNFAFYVKERQLRRLDMSTSKDVVLAQVKLNKLTQPYYSLHYNPAENCFLLVTRPSNNVESSTYDLYKISAKEGELEPLDAKRSPGIAAVWVARNRFAVLDKNHQLTIRDLQNQESRKVDYTGAIDDIFYAGTGLLLLKNADAVQMYDLQQKHVLASIKADKVKYVVWSKCMKYAAFLSKHRVTLVTKRLEVLSTVQESTRVKSGAWDVDNGAFLYTTSNHIKYALTAGGDHGIIRTMDIPLYILEVRGSRLYCLSRDASPMELTIDLTEFRFKLALIHRRYDEVLNMVRNANLVGQSIIAFLQKKGYPEVALHFVKDEKTRFGLALECGNLQVALEAAKVLDDKAIWTALGEAALLQGNHQIVEMAYQRTKDFERLAFLYLITGNQEKLQKRLKIAQIRKDVHGQFQCSLMLGNAEERTKVLKELGQLSLAYLSSVTHSLDDEAEQLRAELEQRQISVPETNPNAAPLTPMAPLNPLVDNWPRLSTNVEEQQFFDQLQQTTDWIIETEVVIEEPMNAQMPDGQTDDFGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU04</accession>
    <name>A0A914GU04_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g11200.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11200.t1"/>
        <property type="gene ID" value="Gr19_v10_g11200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF2">
        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="312"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="416"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="522"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="923"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="1636"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="845"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1325"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1362"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1536"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1325"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1365"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1569"/>
            <end position="1597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11200.t1"/>
        </source>
    </evidence>
    <sequence length="1734" mass="190502" checksum="9E2DE3B9AA0DAC4D" modified="2023-02-22" version="1">MDRLSSRLSFDEFAPALRLFAPSNRMAFFATNRTVLVSNPSDPFCKQHFPLSTAITPNIHYVCHIIQIVSSVPTPPPAPILVLPPLPLRHLSAHTPLPSGGFWLSRHRAADFFGEMHPLCSFGEADDMLSASLSEFCAKIGEIPEEELATLKNLLEEFDGIFALHENELTQTDMVEHAVDTEDAWGRKGEKRLAATAPAQTPSAATPLPVLHDSFHFFGIPLRTPSEYYRFLDIPSGAKRESESGAASERHFANILGVGWTECKSAQILQRKQQKQRKKCSDPSDQCVCTCALSCTSSAPLSQKPSLFGRAFVQLPRGPEQQLGLGIAGGSDRPIPPTISYLRPGFVAHRCDQLQIGDRLISVDGVRVETLTHLQVLALLRNAGIDSVELELEYDLNSGGLASSQYNAGIRKKTADIELVDGESAEGTFGMTVRGGAFGPDPAKSRPLTVTSIRVGGAAHRESRLRVGDRLLAINGVPVQECTLAAALNVLRSGSLSGHLLLNVEYDVCLLTSLRRLVGPLLLEIEKVPGIDFGIELDIRHIYSSGRIKRRAVIVKRIVPASIADRCGAVQIGDELLAIDGISLEMVSGMAEAYQLLRSQSSMLRLELLPGRDRRERKITRITERRKMTDMDPLRRSDMDSLRRSDMDSLRRSDMDSLGRSDMDSLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRSDMDPLRRLNSSLLQLNSPSNSICSLGRHLLSHPRQQRQPSLPPQLIRSNRQGDKEGGLTTLRRRNNKNSRKNHAQSSGRMSGGVGSITAHLSSSFGPNSMGTICHPESMELKLTQKSAHSWDSFGILLGRQRHEESDADGLVPAPLLVERVERGSPADKCGLVQPGDRILCINDWNTTDGILEEAQSTRSTPLPFSHLLRACSFSPARSVILLVEFNVIEPVLPPGPGSLFVVRLARRGSSLGIVCRSEHKGAAKGEPLIISDVRMGSVAHRCGSIQTGDRIHSIDNIPLEACTVEESIRLLQRSAPIVKLCIAKGGGEEQDILDSSQSVVYSVELSRNGQPLGVTIASAGGVLDPIVISQLMPGGLAERTSALHVGDHIVAINGESMEGKKVGQVTQLLQHCPDPLKLCIEKGGGTALWCSSAEMCSTSNGPLGRCSDGCDETEEASNKVGTPIKSVDSAMDSMEDSPSDIKHSNLRHGTARLTHLRPSTSNNFQQGDLISEQCSGGWDSGLSSAAATDSQNGGQQRPFCQSAGRTAGQERCCGCRSEQPSSTTASNSPQSSSLSTSSRGAKRDEKKEDWARILDALETVGEEEMLRNPTGCAKKCQHFLPFCPENGVLSRRFLPNSNSASNCCAPVSHLIPSAPAGQFAKLSLLDAKMMKFNGENNGNNSPLPTVRVNCPVRTECVKNIVNETSTRPQTPVLGLNRRVALMHNSTFLFELPPSMPSPRPTATTTLPPLLPFPRHPNVHSNKQLETSATSNNNASTFTSASSEEQQQHRSSSAIPFITLPTISSRERDVEDQMEEANDEREDQFDELSEVFSIQLCRCSHTKSFGFSVCDGTADGETGGRREQQKQGIFVRSLVKNGPADKSGRVRPGDRILQINGRSIQFLTCDLALPLLATERVDLLLLRKRSTTNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU32</accession>
    <name>A0A914GU32_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU32"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10778.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10778.t1"/>
        <property type="gene ID" value="Gr19_v10_g10778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10778.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12113" checksum="36EF2E0604781F68" modified="2023-02-22" version="1">MDKDGHQREQQQNNGATFGFPFKPYDIQSRLMRTMYDAIERRRVAILESPTGTGKSLSAICAALSWLEDDERRQREQCQQKAEALGQRIRSESSVLLPFGLIVLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU40</accession>
    <name>A0A914GU40_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU40"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10787.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10787.t1"/>
        <property type="gene ID" value="Gr19_v10_g10787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10787.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9730" checksum="3B9D278E7E795744" modified="2023-02-22" version="1">MSLFLKIFDTTPAHLVDSVSGQLPPQQAYKCRKEEFKGNEKGETDNWGHETTSFGTRNFVCSMATIDLSPNSADRPINDFQLYQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU71</accession>
    <name>A0A914GU71_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU71"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11379.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11379.t2"/>
        <property type="gene ID" value="Gr19_v10_g11379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029865">
        <property type="entry name" value="KIAA0319-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182:SF2">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038077413" evidence="1">
        <location>
            <begin position="19"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11379.t2"/>
        </source>
    </evidence>
    <sequence length="574" mass="64506" checksum="3CCC7BBDECDAB992" modified="2023-02-22" version="1">MNFLLCIQFVILMVKCFSGQVATRRLRCVHATSGCHSAICFLNARVQMKLGWVEFKAVFRDVWKGVNWTFSWSVIDGMDNARFAGMDGPSLNLTNLKAGFVLLTLSVSNATSEGHMSHNLTITDESKYSVRIVECERRANTEFIRLWLPFDKKLRLSGDSAEIVSNKWVRIDHTMNPVDISGSTSSVLELSNFQITNESSPYEFLLSVAFPGGRSSNATVKISVQDRPKVPVIHIRNETIQLPVDSVLLKAQILNNSVDVFVNFTWEQTEGPFQVEFANRHLLSPSIVGQIGIPGLYVFRVHGITIAEDIADAQLFLNVLPEKNDRLRPVILGDNVSVFLPLKYVVLEPMLWRNIDTFTWTPGDNVPAVMLIQSDFHTPTLLLSHLLPGNFLFKIFGYTKMLLQQNFGGDFVPNTNGIFDDGNREILSLRLIFTCTPGSDGRVNLTESKLASVLRNNRTFLEKFKIISIHPTCTSRSDADCGCNSFWMGSLFIFYTKDGQTCACWPVFYAWLPIVMFQEGEDKTLGDLEQNPISSPRKSKCDTVNKALVNGNYETLLDNELEGDTSDFEEDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUH5</accession>
    <name>A0A914GUH5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUH5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11326.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11326.t1"/>
        <property type="gene ID" value="Gr19_v10_g11326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11326.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8318" checksum="AE7986D7181A85BE" modified="2023-02-22" version="1">MFTPPTFIHPLNKPSPSPLHLSPHGVWSRHPFRPRWEYTIINHSLPTAINDHHNTPTSELSLFELNEGEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVD7</accession>
    <name>A0A914GVD7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11137.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11137.t2"/>
        <property type="gene ID" value="Gr19_v10_g11137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000001">
        <property type="entry name" value="Sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11137.t2"/>
        </source>
    </evidence>
    <sequence length="369" mass="40476" checksum="04443DFD84F1FC95" modified="2023-02-22" version="1">MSFPRFARWKLKLSEWLPIYFTETMTPVERRNFALSRRGVVDPVVVVPMTAHAAFDKACSMLGIRLCHVPVDKFTGRVDLQAMRRFIDKNTCLLAGSAPNFPFGTFDDISSIAKLGIEYNIPVHVDACLGGFLVAFAEHSPALAHLPPFDFTVPGVTSISCDTHKYGYAPKGTSVVLYRRSELLHHQYFCSTEWPGGLYATPTLSGSRAGLNIALTWATLQHFGAKEYARRANLILLRTAQLADSVGKIPGICLVGTPEVSVVAFSSNRFNIHAVGDCLGKLGWNLNFLQKPNALHFCITYNQTADGVLNAFLEDLKIACEEVAASPDRGESSKTAAIYGMAAKIPDKGIIEEVAHLYIDACYSMPTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVE9</accession>
    <name>A0A914GVE9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF38 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVE9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1155.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1155.t1"/>
        <property type="gene ID" value="Gr19_v10_g1155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1155.t1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45784" checksum="40D5CEE9A8615DE1" modified="2023-02-22" version="1">MPIPKNDEIEPNNAMAEQQEEEQTKAYPTEKSVTDASIPSAASFRARRELAASRCFSRDSIKQIIACNGGPFPQIVLPPQGGFWMDGVFPCRKVGAEGVRKEDGANEGKDEAQNDADECKHGDERFAKLGERTRPSLGAEIVNARSGVGLPIPEEPLPNEVLGFEEIKISYVDQSVIEFLKQHIRRLFNSEITVAIETEPDQNSSWEIIRQEIWPFVNGNICTFLRLDFLILDRLREFSPAILRNCAKLRTIHSFGLFPEFPADDNADTSSRQAVAKWLLTPRGDGLPKMLYVDSIQAKLNGLKESFVNAAESANFIIKFLKPDRDFVVFELKNNLTRERLTFRQIDKDNWLLVRCPIAREEDKWAKWEEEAIQWEMGRKWNLIAITFEDRDIGEGLAENQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVG2</accession>
    <name>A0A914GVG2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GVG2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11153.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11153.t1"/>
        <property type="gene ID" value="Gr19_v10_g11153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF24">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036825973" evidence="10">
        <location>
            <begin position="39"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="11">
        <location>
            <begin position="52"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="467"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="758"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11153.t1"/>
        </source>
    </evidence>
    <sequence length="822" mass="89947" checksum="2904BB5F206470DD" modified="2023-02-22" version="1">MNAAFFAFGPFRRRFVSPASHSCLIFILLLLFPEGLRLISIDNDIIGEPDIECLDQEIRVWVRTRKFFQGRIYTKGKADDPECAKDDFSSRRTKKVHFDLRLGRCGMKSLRSFDPRGMYYGVTLVISFHPLFITKVDQAFHVKCFFEEAQRGLTAELGVSMIPTTEVEARHGIPGCSYSIHRSSIDDLDAGKPAGSAIQFARVGDKVLHQWHCDDQMFGILINNCFVTDGVKQKHRVIDEKGCPVDPIAITGIRYASDLQRAYAESQVFKFADRPGVWFFCQIQMCMKKEGMCDGITPPACATTNAPPKGIRGRIGTEKKKEEEDDEGGRGGKKGTEIEEGTEGSNSSTEPESVGRKRGEEEHVEFEEFGKRSTESPGMEVEGAGDEQTEESHASGGEAQSDGTPQPEHTTTQIASSLKQRLRENPSASMGGYGVPSPIGTADTEDQAKAAGVTAFGPGYLANQVDDGSFGVGRDPPGGVRSPHSSKLYIPTVSSGGSKGQQAAVSAEFETVDAQAMINRPTTETTTENGPTRDYADYDSDVTVPPNLTDLLANLQPEDISARSLQKMFRDSVIDRRTLLQGFDLLIRKMNKKKTKKDDEDDDGEENAKTTSGRRGGRQVTEEQENGREGEREHRKARESKQQRTARDFLSRSAVPLFAKKQAQPSLSAPNSGQWPDDVGERHSFRQFDASIDPPMIAGQLLIYDLDEKPPNIEELKKSAEDCPITRNGLTIALIGSGSLALILLLIAFAVLSMLPKQSTDGGEETGGTDAEGRKRTPTAGGARSAGDGGRWGSLYSAEDGGGEGGRRRHNERRTATDEGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVI8</accession>
    <name>A0A914GVI8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11577.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11577.t1"/>
        <property type="gene ID" value="Gr19_v10_g11577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="544"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11577.t1"/>
        </source>
    </evidence>
    <sequence length="847" mass="97382" checksum="F8FA27DAD1CB8F8B" modified="2023-02-22" version="1">MSLHDPLAHPARIYFPCATHSRTLREFMQIFSVRVPLAYPARIYFPCATHSRTLREFMQIFSEENYDIELETLPPLEMYYPGGHFPEERKKLESWHRENFNTPFLLREVIADYCRTDVQILAHGVIKMRKLFYSETFDDITDSVTIPSACMKFFVSLAHYDKQKIAIIPHLGYEKRGKQSTIARKYLKWRAEEEMRENGLTLRHVESPGGEYKFGNYSLDGMLERPGDGNNLAIEVNGCYWHACPHCFPDDAAIVGGGKTAGAIRARDAKRIAQIAREFEVEIVWECHLNRLLEDTPAMKAFFDNTPDSGPIDFHDAFFGGRTGPEWLGASVIKDDGVLLPRTIKIKDFNSLYPSRNMFTNYPVGHPTLVHFDKDVHWCKPADVVGDDGYRLEGIIKCFVVPPRHVYYGIPVLPLRMNKRTLFPLCRKCAELFPSGAVDREYSCPHFEDEERGFSVTTPYIELEEALRVGYRVTRVYRAYIWPLACDWSGFLFHSYLEKFLKMKFEASGYPANCSEEGISEEEAAARKQAYIDKAWSVCQVRLNPANIKYNAGLRYVAKLCLNSLWGRFALRNRLTKTEIIDNHSDLAKLLNDDKIDISSIDQLTEKFWMVCYKAKDEHVVEHDTSNVAIALWTTSAARIHLLDSLQKVFCVPGGTWREDTRVLYMDTDSIFYEYETALGDPLPGGEQLGELADEYPHHTIVEFVCAGPKAYALWLRDNTTGEDQYKMKLRGITLDSDACQQINYAKMKEMVLEKWGAVDNYCNFHYPSKNFRITKKGEIFTVPLDKRFNPTVNKGVIRDHGLRVVPFGYTDKEYCQLNNPHCCDCQVFVPDPEYNFNVADLAPESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVL9</accession>
    <name>A0A914GVL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11193.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11193.t1"/>
        <property type="gene ID" value="Gr19_v10_g11193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11193.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8171" checksum="8F88B8E1C4C59CE1" modified="2023-02-22" version="1">MSHSLESWETKLSESASSLPLPTTFFLTERRRQLTLCCQSVHRDRTLTHNNNDDDDNNKEINNKPIIGPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWX5</accession>
    <name>A0A914GWX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plexin domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12103.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12103.t1"/>
        <property type="gene ID" value="Gr19_v10_g12103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055:SF12">
        <property type="entry name" value="LD40707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="TUMOR ENDOTHELIAL MARKER 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12103.t1"/>
        </source>
    </evidence>
    <sequence length="528" mass="58187" checksum="BA55C90BA1C681FC" modified="2023-02-22" version="1">MGADARSSDLLPTKMLLRPSSSVLPVLLLLLLFLAYSAGFSYSELADSLNHDEFVPRREKKEAVPSGVAKDDLLDMNESTFPPEYDVEDDNKEDKKAEGSATTSEHTYYNMTTINNNQTLFDATYVDVAKWISKGGAEGNTKHEHLGDAYRKAAGVRLKFEFPFYGHRLSNLTIATGGFLYVGDQTHSWLAATQYIAPLMANFDTMADNSSIQYGDDGKRMVVEWRDVTLRDNREAGQFTFQVHLWRDGNITFVYKQVPVPVANISDAQHPCKLGISDAYLFNHKVSSLSQAVPQNKRVIHEYHRITISPENIQSNTIVMLKALPTCLEATSCEQCIGMQLKAFKCSWCNPKDSGKGPWKAGMAETGEGGRSERPFCSDQLGLHRRRQEWIEGNCQLQEENQYCKADEPIANTTDASHSGASSAAVSPDGAPPSATTVTTTTTTASTASSTTAKAAVTAKAKRLEGEGSGGGLAFVTMFILLGMSVSVWLLYAYFNPHTRSGQLLIKYRPSKWQIPSSHVRYSASVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX94</accession>
    <name>A0A914GX94_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GX94"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12011.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12011.t1"/>
        <property type="gene ID" value="Gr19_v10_g12011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="2">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12011.t1"/>
        </source>
    </evidence>
    <sequence length="383" mass="45574" checksum="25BD5D43AC8E625F" modified="2023-02-22" version="1">MSLKLSLFYDILCPRSWVFYQALQKKLPYWKTFREFTIDYVPVSSFFLHEKIHHIHPAAIISRKKDYMLHELYDICDFYGLQKGNFEVTYELYTRRTRLCLSFLNYLRLNRPEYYQKFLEKIWSDFWHKSASFNHTSHFFMIGHKRTALDMNARHMQLLFEERIVDIPWLRIDSVPGHEKLFGFTEILRLEMLDKLMAQPCYNPLNHNVENPLYHPLDPEEKITLRVSGTVDFSISMQRFNQTSRFPIGNIFFLPINFNQRFGCAYIKRAYTDGPLTVRGRSPPAKKRANAADEIARTKFELLEPAAFNELPRGQQRFVRQIDKSNRTRVRKLFALNYKMIRGGLLGLAMVIAIYLYTIWVLRQETFLEEIDEEVAMEAQNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXX4</accession>
    <name>A0A914GXX4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXX4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11398.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11398.t1"/>
        <property type="gene ID" value="Gr19_v10_g11398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11398.t1"/>
        </source>
    </evidence>
    <sequence length="438" mass="48540" checksum="AD8760DBD2FF2E5D" modified="2023-02-22" version="1">MDLSSCLEMINLVTFEREKILYLSCFLALASFFSKQLQITITVHLELLRICVLLNALLNPFIYGFKKGQPLKKSEINGWDDKGSERNDKQELSLQGKKRRGGGTLLGAREIVFVAFCKPPPSVLAPSAPNSIQTKTQSIKMDYEARIKAYRFVAYSTVSFSIISLLSVCFTLPMLKNYVANVALNMDRELNSCQGSAKDIWSELVKPVAMEVRAQCPEEAEAEGLAANVVLAEDRAQPDPRDRLGAPEIKELQERLDSQEKRNLLPVNRPLRLPANRALVVNPDSLGLPDRLDNLEGQDSPETPAEIPSLDLPDPLDHLETREDPANPEDLVSQDSLQHQRQLAPLLLARLERLEPRDSLETPARPANPEDLDSPAPKDPLDLLASPETTDNPDSRAALDSREEPARRASVPSTVPSTAESSSRTAPEDVKPKSECVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXY0</accession>
    <name>A0A914GXY0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exosome complex component CSL4</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXY0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12361.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12361.t1"/>
        <property type="gene ID" value="Gr19_v10_g12361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12361.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24420" checksum="1F6E982B19FEE35F" modified="2023-02-22" version="1">MDISASFLDSILPGFSGTDNNGNCEKRACIPGELLFSVADGYHAGNGCYEFHGSVFASLSGFVHVFSLKDSQNAETNIVEVRRNFDERNHVLPSQAKIVTARVELITTKFAKCSIICVEDTALVNGFNSTLRKEDVREKERDKVELHKFVQPGDIILARVLGYGEAHTSYLLTIAEAELGVVIGRGQNGERLLPENSELMKMPGSEYREIRKVAQLPTLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXY9</accession>
    <name>A0A914GXY9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Intermediate filament protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXY9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12226.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12226.t1"/>
        <property type="gene ID" value="Gr19_v10_g12226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000016">
        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1260:FF:000003">
        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000058">
        <property type="entry name" value="Intermediate filament protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000023">
        <property type="entry name" value="Intermediate filament protein ifa-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016451">
        <property type="entry name" value="Intermed_filament_ifa/ifb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF12">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005546">
        <property type="entry name" value="Intermed_filamnt_Ifb-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="10">
        <location>
            <begin position="71"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="9">
        <location>
            <begin position="457"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="61"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="329"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12226.t1"/>
        </source>
    </evidence>
    <sequence length="585" mass="66911" checksum="B1BD6EA8CBBAE902" modified="2023-02-22" version="1">MSDDYRSSIGPRPAFNRNSNAYSSTNGPVAAGGNRVLKIVTETMSSTVSGGGGVSPFGANAAQIRDSRDREKKELSDLNDRLANYIEKVRFLEAQNRKLKADLDMLQGRRGKDTITIKTMYESEINTAKKLIEDTGKSKRELEADVAKLQRDLDEQRRKYEEAVRVRAGDREKLDDLLVQLSNLEAEISLLKRRIALLEEELGKLRKENTRLHSDLQRVRAELDQETLNRIDYQNQVQTLLEEIDFIRRSHDQEIKDLQAMAARDTTSENREFFRNELASAIRDIRNEYDTLNNKNRNDVESWYKLKVQEIETQSARQNMEQGYQKDELKRLRVQLTDLRGKLSDLEARNSLLEKQTQELNYQLEDDQRAYEDALNAKDAQIRKMRDECQALMVELQMLLDTKQTLDAEIAIYRKMLEGEGDGPGLKQLVEQVVRTTGINEVADTETMRVVKGETSSRQSYQRSAKGNVSIQETSPEGKYVVLENTHRSKEEAIGEWKLKRRIDGKREIVYTLPANFVLRPMARLKVWARNQGGLHAPPDQLIFDGEESFGVGSNVHTILYNREGEERATHIQRSSQTAAAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYC9</accession>
    <name>A0A914GYC9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S13</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12469.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12469.t1"/>
        <property type="gene ID" value="Gr19_v10_g12469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12469.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17544" checksum="2029AEAD7E8A97E1" modified="2023-02-22" version="1">MGRMHNPGKGISRSALPYRRSVPTWQKLTNTEVEEQIVKLARKGLRPSQIGVILRDSHGVAQVRRITGNKIVRILRSKGMAPEIPEDLYHLIKKAVSIRKHLERFRKDIDSKYRLILVESRIHRLSRYFKTKRMLPPTWKYESSTASAMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ00</accession>
    <name>A0A914GZ00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZ00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12090.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12090.t1"/>
        <property type="gene ID" value="Gr19_v10_g12090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="304"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="615"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12090.t1"/>
        </source>
    </evidence>
    <sequence length="996" mass="111975" checksum="73D99459CB711473" modified="2023-02-22" version="1">MSTSLIQTRVNPQIRKHDEMSRLLESRNVSFGSTLLEPKKSPGKAGEKGMMKLITNAHLLNLLGKQTIYHYEVTINGVSSRSDRKLRLSEPNGPRDRDDFPLLNRRDKCRDVFMAFNQTMERSLRESGNLLYYDLSKTIFTLKKLELQGEVKYVFNIGTVPSVERPDAARFKHYEFIIKPAMGLEIGDLSFVSNDMAKMDRSLEQFLDIATSQSVNLDNQRFIEFSSSRIYLLAPTEYGFDTRECPIFEANHSFLGIGPNKGCRIIEGEQGLGQMTPSLVIQAKKSAFHIPDMSVLEKAKIFIPREDTGIETGDITHHDHEFIATGLIGIYAEPRYGPSGRFFRIDAVTKPNGGGGQNAENTYINHQISGNITIQRYFREQYHKELQFPKAPLLVSQRRMGEPAYYPMELCYVLDGQRVKGEQSANREMIGLTAVAPTVLKVHNERVKDALHLVNNDYLTKASVRFENAPLHVDFRVIGPPSIAYRDNATLRPDPMGEWTPTPNMNYLTNAKINRWVAYAFALRESDSVRRSGFNEDCWRNFVAKYASEMCAKGIMCPPPSSIFIHWGNAASDVMNILRKEADNHAEFALIGHAKGSEGDDVHAGIKVFEQQTEVVTQAVSFDLVDEIMNKGKHLPITNCIHKTNMKMGGLNYALLMDDPLVSQLFDGQTLFLGFAMNYPGGFAPTETGNIHPNGGNGNGKLGSNGNVNVGNGTNGNSKAISAGQQGRSFGALPPPSCVGWTATIGKHKDEYIGDFVYQSPRRDEKIDVVASVVKRCVERFKQNKKAFPKRVIVLRNSCPEGQFEFIMKYEIPLVKKELEELCCDAKLTVLVPNKLQDVRFVRHDANPDEPAPEQNIRPGTVVDTVVVHPKRTEFFLNSHVAIQGTARTPHYTLLRDENDLSMDTLQAMVHSLCFGHQVVTKPTSLPSPVYIADEYAKRGRNIYAHYSKHGLDNSKSLEKIVKDKKFSWPLRNYDDMTKVLSFVATQYLKDLRVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZX5</accession>
    <name>A0A914GZX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11947.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11947.t1"/>
        <property type="gene ID" value="Gr19_v10_g11947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11947.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9339" checksum="62291372C8ED4935" modified="2023-02-22" version="1">MTKNKNKFGDFGLIREEIGRCAVCFWSSQQHLLLISICAGRRCRGVAVDQSGAVRVRHLQNAGHGNGETAKEVELLQCVEGGGRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZZ3</accession>
    <name>A0A914GZZ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12670.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12670.t1"/>
        <property type="gene ID" value="Gr19_v10_g12670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038093562" evidence="1">
        <location>
            <begin position="17"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12670.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23042" checksum="76EEBA6C212B7CCC" modified="2023-02-22" version="1">MAKIFLCAKVCWFIYAQIVLLHLVHHHQSVNGAYLKVYFDPPGVQYSVTVSTVLDFVLGTYRIIANGLKTKTQPDDRQMIKLNKTKLANLDNVAFTFVRTDGSKAAVTVVHGKQAREEQELTFNYYENGGKLANREHQDVWLFSSKKSPNCPFICQMSDRRKITLINKIMTVPPYIETHGNKSAVEPRYASLQCPHLPAIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H044</accession>
    <name>A0A914H044_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glypican</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H044"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12393.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12393.t1"/>
        <property type="gene ID" value="Gr19_v10_g12393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF29">
        <property type="entry name" value="DIVISION ABNORMALLY DELAYED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037815431" evidence="13">
        <location>
            <begin position="27"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12393.t1"/>
        </source>
    </evidence>
    <sequence length="615" mass="69721" checksum="A47FFA68EB296659" modified="2023-02-22" version="1">MPFWPCEVAKFRVFPLLFALSNFVAPIRPQATCAFVSANFVQFVVDDTPTEPKIADDLLICRHLRGPSVSCCTRRMEAKFEQFAREQLDSVVQGEFELVREFFDNWASTFRAEFSLALNRTERTLRHIFHRTYGHFFTQNIEMFNTFFSHMNSLLSASPASSTFDDALLQLLQRIFLAEFALLNPLRASDLLAHEQCMRHLFPAFAPFGSIPSAIAALHGRTFVAWTSLIDALDSVGELMYSLGRDFSLTSRCTDSVVRMRFCPICFGRHSPKVRPCPVYCQYVIRRCFHELTAAIDLQWDGLIDSMVRLSASLISVHNPHISLAPLPFQLSEAIMHFQENAQLLSGRILFRCFGDDLQKIVTERGENGRTKRDLSMTESEDYDNEEEAEEEAEEDEEEADEAVEDEFLQATAASSAFSSARSLRRSIERFTDKLLRMKGFWRGLGRMLCQEGGIQADVRGSDESCWNANGRESWWDGKGGEGAETARGKATDQPTAGNFADKFAQERTAMEAMAKRLQFANGKRTEIGEKNTNRMENVTSVEDNRHPFEEPVNAIDVDDYKPDDYQSYESVGKWWHWSDVEKRPEGKTNGGDDGSSRIAISQATAILSLLTLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H082</accession>
    <name>A0A914H082_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Transaldolase</fullName>
            <ecNumber evidence="3 7">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 7"/>
    <dbReference type="AlphaFoldDB" id="A0A914H082"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12422.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12422.t1"/>
        <property type="gene ID" value="Gr19_v10_g12422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12422.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32313" checksum="BCDC6D2CEA3F7D5E" modified="2023-02-22" version="1">MITIERQQSMQMELRLHIWHNFTELQSDTGDFHAIEEFKPTDATTNPSLILAAAKIDKYKELIGKALQYAKEKAAGKPTEAVAELALDKLFVLFGKEILSIVPGRVSTEVDARLSFDKEGSIAKALSFIKLYEEEGIGKERVLIKLSSTWEGIEAAKVLESQHSVHCKCYVDFALRWQNFGLTPFGHKTQVMAASFRNTEEIKGLIGCDLMTISPALLGELAKDFEVVGPVLTVESAKNCELERVEMDEKIFRWQMNEDAMSDEKLADGIRRFAADAIKLEALIRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H089</accession>
    <name>A0A914H089_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H089"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12740.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12740.t1"/>
        <property type="gene ID" value="Gr19_v10_g12740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12740.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18151" checksum="C3DA5EE71319D884" modified="2023-02-22" version="1">MVVGVNWAFVAQMTKMGLNAKFVGFDIEASAVDSPKSAQTMFIGFERIRISFSLRSSELDCLRQISPTVLGDCAKLRMIESFDSFSRISRMTAPALLLPKHWPNGCTRRGDGLPKVLNINVGVCQKRKLKKAIEFVRCLIERDEKKWAEREQAGLNGICVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0D8</accession>
    <name>A0A914H0D8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12886.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12886.t1"/>
        <property type="gene ID" value="Gr19_v10_g12886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12886.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13937" checksum="97DD2844D107160D" modified="2023-02-22" version="1">MNSLTPKSDASSSDESPLFPLTAHPSTSSSDNVLLEEDPFYALSTAIVPSTSHLKLTGAELLEHLRQMSPSMCRQGLLNRFEELANLLAAGWKYHVANTDGVKEAWTRFEDFYEDVCSYTEGIVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1F6</accession>
    <name>A0A914H1F6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1F6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13263.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13263.t2"/>
        <property type="gene ID" value="Gr19_v10_g13263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF296">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN DEL-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13263.t2"/>
        </source>
    </evidence>
    <sequence length="772" mass="90134" checksum="F3475B6460439ADE" modified="2023-02-22" version="1">MLRYTWLVLIILFICLCFYQIGAQAMMYWLTPVATNIIAMYPESLAFPGRRPNSSAPNWFRRQLNESDVFDRVMLNSWDMDAGRFLRTAAHQRSRMIVRCELPNGSQCSPKDFRPLWTLTGLCWAINTDPDRPMQVTGAGPGNALRLLVNVERYERVESCTPKLRARSLPGVKVLIINQTDIPASYLEGVNVPAGFTMDIPFWMRQRQKLPGRDCVVFSPSEDAKRSPEEKEKDNSEREDARGCLMSSYLGEVERRCNCSMRQAFLQKAADPSPGKGRFTPCNVLQYFDCVQAVLEWAKDKGFSNFRHCPVPCESIDYTAWQDMNELPANIFPRIISFGNNDEEDDDEANDSGEEDEENSDELNSQNYHHCAHNQMLRGQHVLRIKKAARDALEKQARFQEDIQIRTRRMIAQLRRSVERLIQMRWGWRQEHFLGVQRRLAERLRCYDEVPRTHANVFNAMANPKGEEERAQQLQELLLGERRNNATKRAKSIEEVRRTFGQKAETRHREMLMARELTSRIYSLFSVDSFTKRLPSGLERMDKVLQLIKMYEGGQMSRKSWAERMQTRNMRHFLEEDLYEDWHNLIVRDMEQNVLEVIQKIEDLVPLLYQNASNGTAILCIFNGIRNETAQMLREFQRAMYELQSALTVLFRKELPEYLQNMEFGPKFIQENFAQVNVFLHKMNIEYWRQEPTYSIWSFFCDIGATMSLFLGASMLTIIEVLYFVLRHSRIYRSIAVWRHRKNPLATAEDNDGADAVRKVSVNKDRTSFVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2E3</accession>
    <name>A0A914H2E3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2E3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13370.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13370.t1"/>
        <property type="gene ID" value="Gr19_v10_g13370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197">
        <property type="entry name" value="PROTEIN ABHD14B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13370.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27312" checksum="A2796CD5AC437DBB" modified="2023-02-22" version="1">MCDETNSDASALCTLIKSIDLEKALPKRLECLADEVEVIEESISEQVVENGEDLVSIRYLSSFPPISQRLGSTKFDNYILLLHDQTNDANVWQRTLQVLSASGFCCIAPHLTNFVFDEEKIIHFLLKLSSRVETREIVIVASLQRTATQLRVKALIAIGISDTHRLKEEELRENPLPCLIVRGTFDTSIGLNAANKLKHLRNSRLVEIPNGKHLCHLSHPSQFYKILLNFLLNLSVLPQSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3P7</accession>
    <name>A0A914H3P7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3P7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13859.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13859.t1"/>
        <property type="gene ID" value="Gr19_v10_g13859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF58">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13859.t1"/>
        </source>
    </evidence>
    <sequence length="534" mass="59034" checksum="C20A920F82540CFA" modified="2023-02-22" version="1">MFVLGTITAANSLDITPQLECLENAMRLHFVPEMGPNVPAFGGHVYLKGFFFTEHCHLDYTRQAIDQPFYFHIPFRSECQVKRERSIEGENGRNVSGLSYSTIVIVQHHRLFVTNRDKAYAVNCFYREAKGLLERKLEVGDLPPFDVNGTKEAPVCTYEVLKDGEAIRYANVGDVLVHRWSCDTEELGMLVHSCIIRDGLGHSFALLDQRGCVTDSSLLAPLTYTGQLNSSSTPINTFKYADQMIVYFGCQITLCDKRENGCEGITPPICELTPLPSEGGPEMPVVHASRDHPALAPAHRVLLRNPSRGGASSSLSASTGGPDPSLKAWGRVRNVLNDRDRRWVVISNGIQRLGHQKGGRWTREIGRGNRTVMQRTAHMELRIGNGTDTGDGHGRHKLKKHKELITVDVVADRLIVFTTDEGPTVAEKTRLATDGPQKFGQQGSNFVVECEAPPFSWWPIIWTASAFLLLGIIALLVQWHFFRRKLITLGTYAPNCNSGGGGGNVQFEMAGMPSFLGTTPNPVVAINGKYGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H429</accession>
    <name>A0A914H429_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H429"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13803.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13803.t1"/>
        <property type="gene ID" value="Gr19_v10_g13803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13803.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18678" checksum="E3A5781A730C8C97" modified="2023-02-22" version="1">MVHLIVRHTPKSMRMYSKILLQTCATDFALLTINLLFHQYMFTTDKGESEVIAGGLITFNGTQNRGLNLLAWDWKQTMGFYYIIIACTIAYMIIITLAFLMDKLLNERLKLGASSALTVKMIEINKQISRNLIIQYYRKTFVNGFKRIVRLLNYLHSNDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5L7</accession>
    <name>A0A914H5L7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5L7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14395.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14395.t1"/>
        <property type="gene ID" value="Gr19_v10_g14395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14395.t1"/>
        </source>
    </evidence>
    <sequence length="699" mass="78417" checksum="FF12AFCA7FC2FCC2" modified="2023-02-22" version="1">MEGPTRRRMFIVREIRSFSEPLPQFPVRPSAEDETHRAAPLLAVPGLHPHRPAMPTMATVPMSRAEQPNRTMMIRESAGRRGRYLPCATTQGQIWTRSSPNSRPEGESNSPRENDQRAFTTVGQQLPAYLMVCPVTVAAENGKSECQATLLLDPGSHVDCADAALIRRLNPKKTGSAPLEIQVFGGKKIKMPSGKYWLQLKRTDGEWESLEVSEVEKICTPIKTELISPGATPDRFQTTTVTTQPQLLIGIRKFWDFVQGFRKSEEGAYLIDTVFGTVLCGERFQAATGVTPDPTVFAIAPCGDDEREQMPAVKAVEQFWSLETIGIRDDPTNDADAEAVIQFERSVQQQNDGRYSIRLPWREEFPALPTNYSVAYRRLIGMLQRLQRTPEVLKQYQQTIDDQLQSGVIEETTIGTGQREYFIPHQAVITPKKLRIVYDASAHAKGVPSLNDCLLRGPVWLPDLAGMLIRFRACQVPVIADVEKAFLMVGIEEADREMCKFLWVRDPSAPITTQNLASYRFRRLAFGLTPSPFCLAAVVRHHLRKYGSNFAEQLIRDTYVDNVLIPADSLDEAAAKAKEAKEMFAAAKMNLREFLSNNSVLNNSFSEADFLGKTTAKMLGLEWDAACVNTRRAVLKTIASLFDPLGFLAPATLTAKQFFQKLWDSTHGWEGVPSPVSSWQNLGSNRRRQQRRSPSREWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H648</accession>
    <name>A0A914H648_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H648"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14031.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14031.t1"/>
        <property type="gene ID" value="Gr19_v10_g14031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037364244" evidence="1">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14031.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="27035" checksum="736ABB2DD211C04C" modified="2023-02-22" version="1">MFFILLSFALTFIGNVDASGNLHHKNKTLESAQFDDKNEKDLKISIENLRKKLDEQLITVVEEKFHRLAIKLDELANKIVENKQQHEKAFIVQIIDETRPLYVDAVIDHLLLLAKLRRLFNDPKIKNEVVISEVLGAVSNQASALCDNFNTEIMKLQTYHKERTNLERELERSQGDEALIEYDQKFVDILLLNLEENRDFIITLLAMLEKHKELVLACEKKIKKDDFISIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7C7</accession>
    <name>A0A914H7C7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CYTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7C7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13895.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13895.t1"/>
        <property type="gene ID" value="Gr19_v10_g13895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028:SF2">
        <property type="entry name" value="CYTH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="SI:CH211-156B7.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="12"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13895.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24584" checksum="EBC4458571EAC17E" modified="2023-02-22" version="1">MLPKSAIPVVTTRFVTAKVRVEDEETMQRSLFTLTDSQGLLTDSEEIFFRVPAGQLKLRLAHPGKDIGTLISSSCQQINRQLAYKLNIWEVRISEVSTGSNQLRHTLALALEELAILRKKRRTFTLGHAAHIHLDTVEGLGSFLDIEINPTADDDTTEKMFIRAENLLRRLNIANSALIPHSYLELYLRERDKCDDESDDTAFSDGSAPSLRSRITTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7R4</accession>
    <name>A0A914H7R4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7R4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14000.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14000.t1"/>
        <property type="gene ID" value="Gr19_v10_g14000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14000.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="6501" checksum="2E3B80E803900226" modified="2023-02-22" version="1">MKGEPGLDGLPGLQGPPGDSGIPGQAGMPGYPGMKGEPGLDGMPGLQGTPGVCPENCAPSSKTPNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H896</accession>
    <name>A0A914H896_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H896"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14950.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14950.t1"/>
        <property type="gene ID" value="Gr19_v10_g14950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="226"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14950.t1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45581" checksum="75A02838B4E3555D" modified="2023-02-22" version="1">MKEAEFEKFEKWYTENYETAFELSEQLKAYCENDVEILMAAVLKFRKLFLGITKDMDVLKDSVTIASIVMKIFRAKFLKERHIPILPEGGFEKAENQSKIAVKYFEWLAYRDGVKVRHACNGGEIEFGRFKVDCVIGSQKKIVEFQGCAWHGCRRCFLPWTVGPNGLCAEQNFRRTEMRMAHLSDICGKLSVEEVWECDVKEELKKNREMKKFFDSVPDKGPINPRDAYAGGRTMPFCLFAEVSESVEISMFDIVSLYPFVNYDTPYPVGIPKIIKNANYNVLWTRPDDVPYDGLLKVKVIPPKKLLYPLLSVHIDDMLLFPNCGICARRAKKEFVLAKDVKRTTSAARVKLYEYMEKVYNAEGCKLLYCDTDSLIFSHPRSVCPLKEEIFWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAY9</accession>
    <name>A0A914HAY9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAY9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15849.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15849.t1"/>
        <property type="gene ID" value="Gr19_v10_g15849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15849.t1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45023" checksum="46A870D8A6861876" modified="2023-02-22" version="1">MKSEWDPLKTKSDIKQRLNRLFGRFDQYSEFAVKPRVPDDTLTERVTATTTSDSPDPAKEKGQTLREREEGDGAVCQQQNDDTAESRDLEDLIGRLVNVSKPLSPVRFASEKPTTSSEIESSVDTQLAEQPECSTRLSSDLDVLLQHITFVEPLISPIRSDSSFCSEDTSKRKKRPLCSPRFDDVPKRLALQADGHKSAEPLTREQPATARSHKIKLFLTKQSFLRLEQVHDKKLDRQLGAQAHQTPPQEAPLANGSAGGQPQIGQGQQQQPPTGSMQQQNEQNGGDTLPTSANAKSQQQQQSHFGLFPPPPPFMPFPQPPLLDGLSDAEIVAMEGTERRAVEARIQSLRNISILLDAALLQFQHYLRITSPGITSLVQRDENSAQNSSTSTERTNPDQQQTGTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBE0</accession>
    <name>A0A914HBE0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBE0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15037.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15037.t1"/>
        <property type="gene ID" value="Gr19_v10_g15037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036850715" evidence="2">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15037.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21792" checksum="94CA41C24ADC3479" modified="2023-02-22" version="1">MEGFFILILVLFFATNSLDKAESVKLEELPLQTFDELFVDEWWEKDEAAEDLKTPAPTNFGQNVHHQIERQNTQIGQIEPNSNDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIETNSSDQNALLTESDHSYNANSNENVVEDEQKRNLAKPNQINTSKANKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBW4</accession>
    <name>A0A914HBW4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBW4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16088.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16088.t1"/>
        <property type="gene ID" value="Gr19_v10_g16088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16088.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16752" checksum="D6A9C4E07185D62D" modified="2023-02-22" version="1">MGIAIVSAIYNTFIAFLGISHIAIALENRLSLNTLELLSKAYSNPLWVKGQSLVLLRRTDRIQTGDLQNAWAMKDPAPKGMKQCGQTMPFKSMFQRFYTTPVMDPRQYDLAVIHGAVQSNTSGVKRAILLTGIIHLKLHSIALPQRFPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD48</accession>
    <name>A0A914HD48_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase M12B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD48"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1626.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1626.t1"/>
        <property type="gene ID" value="Gr19_v10_g1626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057401">
        <property type="entry name" value="Adt-1/2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF200">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25379">
        <property type="entry name" value="Adt-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="12">
        <location>
            <begin position="293"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1626.t1"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123793" checksum="BDB74A9B0B1F0D3B" modified="2023-02-22" version="1">MDSPSSSSHFHNPISCSTSTSPTPASIFCGHRPGTAMRGRTSTTTQFRPSSNSFSRGTFAFAFSSMPSILLVALSLLSSLQNGLCLVSFFSADDLKYTFGVDHLRSVPPHRLVSPRLIPRQRPVRPDEPMFDLYLQLFANERPLLLSLYSVTDQLLADRFTVVRRTRPDGGGFLQTERAPRAMAEDCHFHHRSEHILAAISNCDEWELKGTIIHNGSVHVLHPIPAHHMARVRRSTGDRTKALHVLYRREAKSAEDFCGIENTISSEELVENEAGVHEDAFVAGQKLMREGDLLVELAVFVDEQLWRHFSSKYGSLAWQKLQQYMLTMLSNIQIMYRQPTAVPSLTFRVVRYEVYQTQPSAIAAYLHENGNAQRYLDMFCRYQRNLGARDWDHALMLTGFDIHRGYGATSISGIARLDGMCDSWNSCTLAEGLDFTSAFIGTHELGHAVGMRHDEPYCSGTFIMSASLGPGKVTWSSCSMRDYQSFIQRLDARQNNCMRTSLLREQLPLTESLKPGQIYDAHEQCRLMHGPSYVQVSPRQDHYDGICHMIWCGQSNYGRIITSHPALEGTHCGANQWCSLGRCVPWNVGFVTPLAPRPSLQAAAVGTLAAFPTTTPSQIDGQWSAWSPFECRQCSCSDISGAIGVTLSQRNCSNPAPLNGGVECSGPAHRAAVCARKCPQGSQSVDQFISAKCSEHKRTRQDSELTGTGSQLSRFPQRACKVFCDVKNPFGAQRNYRFYGDNLSDGAPCGVDRYCLNGECTELSCEDSMLIFGEDMEDYCPSSQQKCSAAQPDPEEVAKGHWEEWSFWSPCTASCGHTGIQLRSRTCSGANQCEGEPSSESQPCNRRILCPTTSSDDAQWSEWTPWTQCSVSCGRGSQARYRRCTTPQNAVAFTCSGQTMDLRNCEELPCVEITEQRRHYGHWTEWSAWSTCSSSCGPGSTVRMRACSQEPCEGASQQKLDCNLKECATWSQWATWSDCSLLCGKGMRSRSRRCPAGSTCPGTGVEQQPCNEQPCDQSADSQTGLMWSDWSAWGPCSVSCGNGVRRRTRACHRENCAGSHFESAICNEAECAVSDALWGGWGYWSPCSESCGFGVRRRVRKCYGSGDLHKCPWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD57</accession>
    <name>A0A914HD57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD57"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15941.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15941.t2"/>
        <property type="gene ID" value="Gr19_v10_g15941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="351"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15941.t2"/>
        </source>
    </evidence>
    <sequence length="421" mass="45115" checksum="49CFB8F271D8420E" modified="2023-02-22" version="1">MRNLKNDSGCRVQMSKNQEVYHGTSERICLVKGKLASTMIVMGAILEKIQEKIDANHAADHFDLKGLDRTKEMKFVVPNTSAGMVIGKNGASIKEIRDTTTANIQIYPKAGSEEAKMSAERVITVGHESNDVLLSAVQRVLEKVVADPMHAQPISSETQMSSGFDFSGSRVSTGSSQFGGISNLGNSSDSLHGKAFGGPSFKFNPLQGTGNNELLAFLDNLQSTLRSSGFNDQSVSEVMQAMQVLAKYNIMGLGLGLGVAAMAQMRNNESAMAQQSVLLLNTPNSSVQQQRYEMMPPSNLSSSLLDSQPSIDQSIVGGSGGVLIDVMSQKKTGSNGTNSFANSVIKERIVEDGHTELEVPDNIVGAVLGPRAKTLIEIQQLSGCKIEVHKRGSNTASPGGRVVRTLNDLLNEVNVSMRLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE36</accession>
    <name>A0A914HE36_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HE36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16172.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16172.t2"/>
        <property type="gene ID" value="Gr19_v10_g16172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF533">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE VHP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="323"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="388"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="859"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="938"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="972"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16172.t2"/>
        </source>
    </evidence>
    <sequence length="1038" mass="110692" checksum="78AD88CB8314ADD0" modified="2023-02-22" version="1">MKRLLNFFEGPSLELECVKWGAINLCGHKRTNKTTTTTTTTRPRDLGRVDDSSGNKFFFLGNFRCKAMSGVVLAKSTITTTATRRARPTTLGVPQLQPQQQRGTRRRATDNQNDAETPGGKAAAALEGSDVYTPCRRARLCLDLCSPTAASVAAAGTESRGMPTGYGDSINRPSILQKDFSLPWNNSEQQQQNLQNCGSNNCNIFGGQRPQPVPGGVTMMNMDKKILSLETRRNQLVSPAPPVRHFCVLAAPPPQPVLEHDVLLGSASFAARRAAAAAASPPLSGSMSCANLSRICAVQSPVVPLHFSSSCSSSAIDQLQAVEPTQIFDFLFLGSQNDALNGELFKRHGITRVINLSETCPPPNALPDDAHHFLRIPIKDSYCAKLLPHFDAAFKFIEEARKTGDKVLVHCLAGISRSPTLAIAYVMRAKQIVSDEAYKFVKNLRPSISPNFNFLGQLMEYEKQLRDQQVLQQMPPALSPRPPSPDSTTTAASSSTTESSSCNKTSSSSLSVNDGKGAEVLDDNKPIMPISVGGEHAEKRQRLKISIIEQPPSTTITTTMTAASSLAAAASTAAMVVVTRPCQLISPSCRSRFSCPPMLPISSAAAGGGGGVAVNGGVGIMKGGDAAVHAKEAVPSPSTEFSRLGIGISLSNPCFGINLPQQQAVLPPKKVERNSKTGTAGDAPMGKRRWRQNVQRTSGGGGCSTGNSLANSLDSSTTTKRKQMMDFGMSFSARNCVLLPDAEDELFRTEECNTGEEYDFGGRTGRSRAMMNEDGNIWKKMKEDDVEHAAEQQKMPKKMEDGGTNEQHFVVLPEQGHHHQRHGAVKKSSAGRQLLSNFRHHFQSSNKFLPTSHHPHAVGCSPSSVPVRHHNRHGQPCYHRSAAASAGRQPPQPVLTSSSSQQHLAASLVPSSSNRLLMTSLGMRRNGGDAADRAIAATGSRGVGAGRRTTSQFRQSLPTVPDMDNDDDGCACGVGGAERGGQEETGGGGVHGLLASSSSSAAENPSSPSRTQQPSSSEMVDDHASMGSASSSQEIAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF79</accession>
    <name>A0A914HF79_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HF79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1697.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1697.t1"/>
        <property type="gene ID" value="Gr19_v10_g1697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1697.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36709" checksum="AFF2CC5BD4C9EA28" modified="2023-02-22" version="1">MNYTMSSNSKISKVYFELANARPCWTLIIFASIYTILAIVGIVFNSSVVYVTIRTKSMNKSANKLLAIYSFFEIVHQSGHFLFTYLVISGQYLMPYKTVIRILTPSNFAVCCTLFLLFFTSIDRLICVIFPFRQSENVFFYVITLPFIGLCNVLYVSSQSCDSADKTLVTGTMTDIGITTSYQCANSPDFIWPTMIDLMLLTTIVLYVVIAIIIYFKKSPPNSNSHQFNIRIFRALFCIVSVNISGYFVMYINVLIIFPAFYQNLMFLWTLGEMIGILLNISAASNAPILYFTSTEYRKAFDKEWETIIKWFNRNTVQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFM4</accession>
    <name>A0A914HFM4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16183.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16183.t1"/>
        <property type="gene ID" value="Gr19_v10_g16183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF1">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16183.t1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39102" checksum="BBB1C30DD64832A6" modified="2023-02-22" version="1">MFMLMEGTRMASFSLSSSAAAADDRRPVHFPPPSSSTAPSSMDVHSEANNDVGSGNTIKTMLLESPAVAGAVLCCPSSSSSPSLVVLFMITLLEAPGSVRRGFASLEDEQTNEMFDDDDIEWSEEEEDNEPVEPNCVDRCLAVGRRPDEADFSEKWKREFSKRPTWFHADMALHQILRGRATGFRWPLYSRIIIQRSLFGIGCFVQRHAWLIIVFVLALFTLFCCGLRYVYIETDIVKLWVSEGGRLNEELNFLSTLQKANRRNLTQDSPYEQRHFLSEDLDERLFEIPEDEAPISSYQVLIQTADHLTPSRNVLTKKELLRHVQLLHEITQLRVHKFGMPEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGE1</accession>
    <name>A0A914HGE1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGE1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16927.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16927.t1"/>
        <property type="gene ID" value="Gr19_v10_g16927"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g16946.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16946.t1"/>
        <property type="gene ID" value="Gr19_v10_g16946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16927.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16946.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15400" checksum="6FD8508EA50B5FA9" modified="2023-02-22" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVLALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGU6</accession>
    <name>A0A914HGU6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGU6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17048.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17048.t1"/>
        <property type="gene ID" value="Gr19_v10_g17048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037825096" evidence="5">
        <location>
            <begin position="30"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="310"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17048.t1"/>
        </source>
    </evidence>
    <sequence length="834" mass="91555" checksum="DD1E13EC353C26BD" modified="2023-02-22" version="1">MAAFHLPNAKKSAVLLMLMFLHWAMPLQTRHLDQNDNNEIGGETRGAGAFSCYTCNVRAGQDDRERCIDKVEECPAASALLPSAPFNSCSTLLHLDFDASSRTPTELQPTTVTDGQRARVRKFCTSPGSAELLAPLLTLLAENGGAGGVCQPLDSWAHLSADPLLPSIAEGSTRARLLSPRRINARRGQRGTTVRPPAGDEPSGRVGTVGPPAPPTSHSATLLCVCTKSLCNEGDFQDVLSRSIYVAGMDGKAKFVAETAGDFEINVVCVLSSFVCPPAPFLPYCFSSSGCSLLQSTVLLLDPVDGHVVEMTAFTGVPYARPPLGELRFEKPSKPKKWSKVRNATEMPPACWPLSRDEIWTEPDQLSEDCLFLNIFVPEKLPAADDNLCPVLVHIHGGGFQAGAIRQFKPGAIAKFVRRGLLFVTVQYRLAMFGFAATGADSFAGNYGLWDQAMALQFLHKNLPKFGGDPARVTLWGFSAGAASVGHLAMCPQTHGLFNGATLAEWAASNRVLVETERLATAVGCAELENSENLKKCLRRKSPHELMDGVDKIGRGRAEINFLQFHPRFDADFFPDDPVHLIEKAPPKRTLMGVTSHEALSFTLFTQDPNLISTQIPRAQWANFGRAEFEQFVAEKVAPEKVFGEATQKVHQRILQFYVGPNGQNDSEYWLAKYNEIITDTMFLVPMLSEAGHKSAAGWPIYLYQIGHINSGFPADIPVKGCFHGVELDILFDIHFPYKVENATESDKSFQLELTEAITNFAKTGVPRTQSLPNWPPIDRQSPLQYARLNSGTTEVGRALAPEKLDFWRKMGAEFPFDIIRGIHRDTLRSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI17</accession>
    <name>A0A914HI17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HI17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16825.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16825.t1"/>
        <property type="gene ID" value="Gr19_v10_g16825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="411"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="802"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16825.t1"/>
        </source>
    </evidence>
    <sequence length="911" mass="101001" checksum="69F8D0C5D26B2F77" modified="2023-02-22" version="1">MDTGIVARLVVPLNLRKQHSSKRTPWRGILLFGPPGTGKSYIAKAVATEAQNSTFISVSSSDLVSKWLGESEKLVRELFELARRSKPSIIFIDEVDSLCSSRSDNESESARRIKTEFLVQMQGVGHDMDGILVLGATNIPWILDAAIRRRFEKRIYISLPDTNARKDMFKLHIGDTPNCLTEENQRELARKTEGYSGHDICMVVRDALMQPVRKVQDATHFKRVSGPSPHDPNVNMHDLLTPCSPGDPGAMPMSWLDVPSDKLSEPILSMNDMLKSLMSTKPTVNAQDLKKLDEFKKDFGQEGMRKLHVKAGGQIKIRWEACPPFRSPRQPRPSMIHGGSDAIVVVVEVIVHFSPHFAVPWASSIFAKISTLWQSLASSWYCSMSLFSMSCLMLLLFEPVHAADLAELKHCFERYDGHRLSVETVSPFLSEWRRSSEEQCLEFCVRSASRCGSIVFDKVGHVCHYFTSKGLANLVRQRKFVYLRVTDRNCMDSLMAKLLGKESATNTHKNSGDVDGTSHVDEHATPSDNVHKMALGNATVSTVSNTSAAVAGGRNESSSLSAIGALLAQLDAELAKQSLAVGSSSPVAPEPFPASAAAAAAVPFALNDADEANALLAKKGPTISDREIRRSPRINDRGNRRQQHNVITTTYEDEQQRQAATATTGDEQQQELVVEKEVSLQGSEGELSMSGENPCENSDLTHRIWLAVENTRMAQAVDANNAPQKAANTPRECVRVCTDLMVDSRPCNLFSFFEHEKRCVFGSSGNEFPAHGSLESIHDGNFSERTFRQFCFPASLSPFENCAEFLAFTDYRLEMEPREIFDGLPATAQGLSACIELCVLSSEYRCMSATFDSVHGICRLFNEHSLTNPNAFREHRDQSQLYFENGCVESAGEITQEISQKGSVRRMHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIC9</accession>
    <name>A0A914HIC9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in several stages of intracellular trafficking.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17438.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17438.t1"/>
        <property type="gene ID" value="Gr19_v10_g17438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090389">
        <property type="term" value="P:phagosome-lysosome fusion involved in apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06892">
        <property type="entry name" value="PX_SNX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000008">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000001">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014637">
        <property type="entry name" value="SNX5/SNX6/SNX32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF1">
        <property type="entry name" value="SORTING NEXIN 6, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Snx5_Snx6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="57"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17438.t1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50712" checksum="4C5DC47B28100C58" modified="2023-02-22" version="1">MLSSTNVKIPHPLNNGEGVSNGEFSEIIGGSNESASDDLSTLTSGEKEHDAHAKKIATQTYSLVVNITDALSEREKVKYTVQAKTNSPEFTKTEMSVVREHDEFIWLHNCLEDNEDYAGFIIPPAPPRPDFDASREKLQKLGEGESTMTKEEFLKIKQELEQEYLATFKKTVAMHEMFLCRLASHLVFQKDQNFRVFLEYENELSVRSRNKKEIVGSIFKRFTQTADEVFLSGQKDIDDFFEHEKNYLVEYHTHIKEATARAEKVCRIRQNVADTYARISHGLEKLGQLEAASGEKEFGQFLAKVTASFEKLKKAEARVGTDEELKEVDTLRYFLCETQAAKNLLYRRTRCLANYEAANKNLERSRARNRDIPKAESEQAESCKKFEDISKLARRELVNLNNTRIAAFKKSLSELAELEVKQSKAKIAILQSSIAALTVMPEQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIR0</accession>
    <name>A0A914HIR0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIR0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17750.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17750.t1"/>
        <property type="gene ID" value="Gr19_v10_g17750"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054177" evidence="3">
        <location>
            <begin position="25"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17750.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32278" checksum="CA8BB21109E07F3A" modified="2023-02-22" version="1">MGFYQLVLARLGLLGFLSDSVVHRFPLPVGDQQQQQRNETQKSDELALTNQVCANANLNSLCQIRRHLRVFKVREETALPPAKVLLLSSLSHNGVPVHPLQFQRFLRSEEVNDGSVLLLYDVQGWHKVLLSLIIFSQLGAFVAMCTGVCAPCFPPTTFCFAISLFIAMLLSMLADGIFFFYANRVDVRFVTGMVGTYEQVIGYAFYLHMGGTLCWVFAFLCAIATTYKFLTSDGQQRKLFEDGPPLHSAARASVYRRPVVEWSAGSSAGTPQRAAGGGKSAGTLRLIGSNTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJI4</accession>
    <name>A0A914HJI4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJI4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17468.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17468.t1"/>
        <property type="gene ID" value="Gr19_v10_g17468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038023756" evidence="1">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17468.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="19090" checksum="F9CC9BAE80CE5719" modified="2023-02-22" version="1">MFRPPALPSRLYLPFLLLLLLFAHFGGGLSRRWLDDSFINRTFKPRRYRLTLSIRNYNVTDARFFRLIGVDNTADFYAAPGDTFTNTYTVNRKGAWVLFVEFPGNRYAKSRRKMISRDSYPQWMMEVYLFPPDNVGFSEWYKIRRPKKRKRTRRKPKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJY8</accession>
    <name>A0A914HJY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17314.t3">
        <property type="protein sequence ID" value="Gr19_v10_g17314.t3"/>
        <property type="gene ID" value="Gr19_v10_g17314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17314.t3"/>
        </source>
    </evidence>
    <sequence length="300" mass="33212" checksum="61F351C69FE46AA1" modified="2023-02-22" version="1">MREDGLKGRRGGRLAEGENVLDFSTFSMGCDSSAQSMPHLIDHKIRKSSSFSGEEETFGVESFERNLRYSPHEVDRQHFAVRTFEEKFPLGGDGADSVKSGGVRFEDLSESVYEDEEASGRGETNHLLRRSPHLETTQLRIPRVQIGSSVERGLGKGCSAERGGRERHSPSSPSSCHSFGGDSVAQRRLPLSSSTSPHSFAGTYLQNVPMKKVVRRSRLVSIHDGRPMDEGRGRSSSSTWRTNRDLWDAISSSSCSLSSNDERETNAGMRARGGDAEWAKKTGVVQLQHNPLFYDAGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKQ8</accession>
    <name>A0A914HKQ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKQ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2222.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2222.t1"/>
        <property type="gene ID" value="Gr19_v10_g2222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="216"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2222.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="53219" checksum="07C65624A9BE450D" modified="2023-02-22" version="1">MTGKATGLRERTTGSVRVAEEDTLHRTVPIRLESNVVVAAKLATYNPFVRPVAPIFSPECSPMPSSPRSVWHVELNLECSVTKTKAPSIMGLDWIVPFEQATQLAIATILLFPQAPAVLRHSATHRRPAQIGGANENFFSQRFSARSRSLYEDKSSSAPQIAGEARVLQSPSGATWSFGGRGQGIGPTTGNRSDQAGRFFPLAAPVLAVRKKSGALDLRDAYLQMELDESSKSLVGINTHRGLFAYQRLPFGVKSAPSIFQKVMDQMIARLPGVFAYLDDVIIASSVVFAGAVTTTLSNSHVNWCGDIPSLLGMQRRLISTRLMIRSIRYSRDHLFQKSSMALWVAHHRWASLSEDDGLKIGSSSFGASKVIWACGKSKSMGRMAKGTSGSSETKVIGREFIVASNAERNVYNSSHRRSFLPKTRRKQFLMSAFNRSYTPPDQGLKLGIIFQSIVRSKTGFGVDEAGGAFGRRLRTQVYGRGECID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLB2</accession>
    <name>A0A914HLB2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLB2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1839.t3">
        <property type="protein sequence ID" value="Gr19_v10_g1839.t3"/>
        <property type="gene ID" value="Gr19_v10_g1839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1839.t3"/>
        </source>
    </evidence>
    <sequence length="408" mass="46328" checksum="B63A53B167B31F4C" modified="2023-02-22" version="1">MIALNAASQWSKDGCVTISINRAVMEMLATQLLPFNLVDGAGFRKLIEKLQPKYELPHRNHFSQYELPKSFDRAVIAELDVVDNIALTCDGWTSKDNRHSLISVTGHFLDRKLRPKFLVISAKPIKGRHTADAIVAFIREALNDFTIPEDKISSITLSRCAAHVLQLCIKEGLKNIDEEGRKVRKSRTLTDELVELQMKEEIPQTVLIKNVEVRWNSSYKMLERLMKNRSAINLLAIEHLDLPKFNADDWMLLSSIKNVLSPIYEATLLLQSRNTSISAMSFALRKEGDNRFLAIKNVIASAIESRLKQAEEKEILVIATLLDPRFKAVYLDSTRLNQYKDWLICEQEKAQGKNDLCNELLFQKDASGSSAEDIFSQIEKDANLNRFECLFTQPVCTGNETESGSRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLH6</accession>
    <name>A0A914HLH6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLH6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2231.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2231.t1"/>
        <property type="gene ID" value="Gr19_v10_g2231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2231.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17835" checksum="4C03AB15AED55C42" modified="2023-02-22" version="1">MFAWSQGPELVQCAICGEKVDLFDKITVDKETIHKKCFTCCYCGNGLQQGACAMALSLYNRIGPRFYCSGKAGSCAMLPNDQKEAKLKEKGLATPHLIAATSSVNNDQLLSKDQQYQQQLKEIIRISNIQQQIFNENRQNGTDPTDSSGLSMSEIANKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLV8</accession>
    <name>A0A914HLV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1784.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1784.t1"/>
        <property type="gene ID" value="Gr19_v10_g1784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1784.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58966" checksum="DD4BCFEC1FBBB628" modified="2023-02-22" version="1">MSFESVQKVPNPTPADQRREADAIRTLAFFGVCLSTVSTMICVVSVPLAYQHFQLMGTKMFNEIDFCKARSGNIWNEVTRTQFAKQVQLATAVRAEVVLEKQPEQLLVVQRHTAEQAAQHHKEELQGVRLTEELQAVQHHKEELLVAQHRKEELQEVQRHKEELQEVQRHKEELQEVQRHKEELQEVQRHKEELQEVQRHKEELQEVRLTEELLAAQRHKEELQAAQHHKEELQAVQHRKEEHQAVQQEEHQAVQHRKEELQAVQHRKEELQAVQHRKEELQAVQHQLPVWLPEVLLQPNHLREVVRVVCNLLSRQLVQLQEEEVVIAVAVACLHQGHPDRLDLQDLKAILDCQGIPEVQDKTLHRLLYRPPRTRHAKNASSRRMAKPDRRDRLVPLATLVGPGKQVKEQHQGHQDRPGHQGLTANPGHPEMPESKASLEKLKTPVKSKDLRAHLDRLVSPEATETPGHQAPIASPGLRAPRATKDRLESLGSPGTPARMASQATRANNQPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLX2</accession>
    <name>A0A914HLX2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLX2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2560.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2560.t1"/>
        <property type="gene ID" value="Gr19_v10_g2560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2560.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18781" checksum="93136D37C42ACF17" modified="2023-02-22" version="1">MKQRNQTEKILPESTEENAIISSGWMSLQLFVEMYSLGLELFMQVAGIKNCITKYSKKMQKIILKLVTHQMPQLDELDEAFVDYFQGKFMHNMPQNFKIEPLEALDEDFVDFFREKLMHDIPQNFTIEPLNTQKIIDQNDTCKAWINWFQKVGLVHSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM12</accession>
    <name>A0A914HM12_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM12"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2735.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2735.t1"/>
        <property type="gene ID" value="Gr19_v10_g2735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2735.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43060" checksum="A7A625B81D1D5685" modified="2023-02-22" version="1">MGFLFSRFFYSAIEPSPKLEDDDNQKQEDSACCSNSENFSPPTVDGDNDDGTMSQSENGTLPLQSMHETPHKVFRKDGVKIFAAFVPDSPERYAFSEFSELKSFLNSPIGKKKGTRFKRCQDEQAVVTFYDEQRLLSSSMQGMCTMSDDQLDDSLNNSSSSSPTSGRSPISVEPDLPYKDVPARRLTEFRVAIEKGDVTKFDELLRESPRFLVNTSNDLPTILHIGMRCNAMHIACRSSNVYAVQRMLALVQNIEWLRDAYATDACVKERSDNLLDALLNTPDKIENNTPLHYACRQLCESIFRELVGHEQCHRKPVNSHNERPIDVLGRGVRSGTGRQESKKVFDRMYVALEGSLPSVHRRRRSPDRQQQLNASNDIGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMA2</accession>
    <name>A0A914HMA2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMA2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2655.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2655.t1"/>
        <property type="gene ID" value="Gr19_v10_g2655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944">
        <property type="entry name" value="PROTEIN CBG02791-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944:SF3">
        <property type="entry name" value="PROTEIN CBG10961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2655.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35509" checksum="90573E5DC6A31D6F" modified="2023-02-22" version="1">MFSKWTRWASLVVSIGVLLCVIAHSRPRQKFMQRKRRSIIGVDQQPNKELPTFTNYPNYLYYDGERECEALCAAQFARDFEEEFGLSYLTQFFDFPIDPLLSSSPSALPRFCRLVHDRQCCLQHECLAQHIAHSPQGHICLKHREDFERAMHCLNATNAHFHFHAACSKAAKRSIDIDRELAETRGFSGQETENYHQQDLRCRFQACTMHARMQLIEMHCAPGEEADDTHATVSRYYTDDLELDLDEYSELLNATRHFPRFCTAFLAYQKKAVLTIGNEYARVYNKALSIFEEEVDKKKQTMTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMW5</accession>
    <name>A0A914HMW5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMW5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2062.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2062.t1"/>
        <property type="gene ID" value="Gr19_v10_g2062"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g2063.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2063.t1"/>
        <property type="gene ID" value="Gr19_v10_g2063"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g2065.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2065.t1"/>
        <property type="gene ID" value="Gr19_v10_g2065"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g2066.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2066.t1"/>
        <property type="gene ID" value="Gr19_v10_g2066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275814" evidence="2">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2062.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2063.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2065.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15878" checksum="D91FF8290F4A7965" modified="2023-02-22" version="1">MLFYPLFLPNLLLTLLGIASVAGTSPSKQKHASVSTHSMEISGTAPKHKNVPRIILNGRTLEIPEGSNPVHVLNSHMAAIRTAQLEKNTQKNREIKPSASGGRDEAFATAERDETSSTTRRDEATATARRARSRRARAQHGEDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN00</accession>
    <name>A0A914HN00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HN00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g30.t1">
        <property type="protein sequence ID" value="Gr19_v10_g30.t1"/>
        <property type="gene ID" value="Gr19_v10_g30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF21">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="755"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="799"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="868"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="912"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="755"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="799"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="868"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g30.t1"/>
        </source>
    </evidence>
    <sequence length="1034" mass="113885" checksum="4C4390EC9E338E20" modified="2023-02-22" version="1">MSSKSEMDELLLSRCADYHQRCRYWAKSGECVQNAWMLENCRWSCGTCVGFWELRQLCRMGGNGRGKRAADGMPSIDFANMDMSSLISRFVREVNRNRTNEEGDGFGLPLRGIPVVGGGASDGASGQLSESPPNDSSNSNQNASPQAPKDDPCKKAPTKALRLYCTQLYRWDQSARFAPSNQEAVTLNPSIPDAGLLAADIAPGAGVSMNSPGGEKAGPNIDEGPPPIPPSAAPPPSSKSKNIDEGPPPLVGAAAPPQVPSSKADFDADAFQPPAGPAPPQKGTVSSNVDPCAAAQTKSQHFVCQKLFKWDKNARAAPPVLTAIPKMPSIAGVPPPDFLVGDLAPIAATIYQCMDLGCLCRYIGGNGQEGSNICQLANGQPLRKALRKEYRMLTDDERARYHAALKAIKQSGEYDNIARIHSNPTIVGGAHSGPAFLPWHREYLKRMEIALRQVDPTIAIPYWDSSLEAQLPTPADSHLFTKEFMGTTDEQGNLVYGHFANWKTIDGNPNIRRMVGRDGKGFTEDEINWFLNQVQIDQIMSYSAPQPGVCAIKMEFRWMEITHGNVHLFVGGSFVLPNGTDEADGDMAEQTRSANDPIFFMHHSFVDFLWEMWRQSKQTRENREKEYPMDNAQCASPQHFGSAPMRPFEPWQNRDGLNNKYTDNMFEYAPRPTCQMGPNCGSKLLFCDRSHGQPHCAAKVRPGGNCTGFINGEDVCLNGICQNGQCQQTNNDNTPTPMPPSPATTEKPIRPVQSCYNEHECCSVWAQKGECQQNPGYMSAWCKASCQKCQPDYDLYQECNNRHPNCQTWTSQGQCQRNQFWMAENCRQSCGKCRVSRQQVCSGGQGSQQNRDRITLAPPASKCASRSCFNENICCQLWGLAGECRRNPTWMNCFCRVSCGRCIPQDYDFGGCADYSPRCRYWANSGECGRNAWMLENCRWSCGTCVGFWELRQLCRMGGNGRGKRAADGMPSIDFANMDMSSLISRFVREVNRNRTNEEGDGFDPPLRGIPVVGGGASDAVRSAGPPSDRLAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN31</accession>
    <name>A0A914HN31_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HN31"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3021.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3021.t1"/>
        <property type="gene ID" value="Gr19_v10_g3021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3021.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="34091" checksum="D760ADC200D475ED" modified="2023-02-22" version="1">MIPARLPSGYNAPKPFALFIKDQITGQRGGPKLLKIISTNWKSLSEDEKQSYSERAKKIGDELRDNFEKLTDGQKKDLWDKHVEKRNKLQRLQMKKKLNKFYTETNRPKQPLPSYLVFMKECFEKQTKPIKTKDELKEFHVELGQHWRQMTDAEKQPYVDQTQCNLAAYHKEMAEWKQKYANEIRAWKEAEAKAARKDTPLARDTQFTEEARFEWNINDDRDIDEKERIQIMLLDDSTHLVERRERSRDDNDRYEQEEAAIQHMFLAISTYLGRKEISQNQRIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPC8</accession>
    <name>A0A914HPC8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPC8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g299.t1">
        <property type="protein sequence ID" value="Gr19_v10_g299.t1"/>
        <property type="gene ID" value="Gr19_v10_g299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g299.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13501" checksum="8809BA156FA1FEE8" modified="2023-02-22" version="1">MPTHFGQLLSGSRRKLFADLYSAQREELIVFWWFRILAVSGSHSVIENPCPPLSSLDDDLTVNIGDRQVTVSALRLMSVSPMQRTINLDWLGINMEQFMEFLEAVSICATPSDLSTILVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPG9</accession>
    <name>A0A914HPG9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPG9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3443.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3443.t1"/>
        <property type="gene ID" value="Gr19_v10_g3443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="436"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3443.t1"/>
        </source>
    </evidence>
    <sequence length="635" mass="74756" checksum="A6F831A29C8B95AA" modified="2023-02-22" version="1">MSISADSTNGGEITADQQECWPPNFANLDPSEELRLLRARIVHLKRQQTINNSPTSSNASFDLVLKNGKRRKISALEQKQTANFEQQKARLAKMEEYQNKQQKTIDALMVSTEQFSSKYQEHEKLLNDHQKLMEEMKEQRKMADLEQQQHQKETNDKIGWLNKDQEQCVFIDQFLLMQSDQKALLGGFNALERKQAAYAEQQKADQKALSSTIDQQFNEREKQLNNFLGQFVEGQNKKFEEQKEESDRMLHKQMDEFKNRLEKGMNQLKGELIAKMEEQYQKEQQKMEQYQKEQKQNMEQHQKEQLRVKQYQKEQLKMEQYQKEHKQKMEQHQKMEQHQKEQLKIEQYQKERKQKMEQHQKEQLKMKQYQKEQLMMEQYQKEHKQKMEQYQKEHKQKMEQYQNKQKQNTNVLSEEQKENEKGRRQNGEVSKTTSTEHRHALTEAQKGNAGLMPQQNRLKSAACHEDLTFSGTDRLIVQFTGENSTWRSVFAERPIPKNNFGIFYYEVAILEQGLYGIHIGLGTKQKPLNRWVGENEGSYAYERYGRFYGHAVGGCSHTTNGRPYIGGKPEFGIGDVIGCGVDLATRQIIYTKNGQRLETTGLFVSFVADLFPCVTLFHSGDKIEANYGPNFECKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRL8</accession>
    <name>A0A914HRL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4014.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4014.t1"/>
        <property type="gene ID" value="Gr19_v10_g4014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037459332" evidence="1">
        <location>
            <begin position="23"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4014.t1"/>
        </source>
    </evidence>
    <sequence length="489" mass="53019" checksum="A27CED042FFFD7AE" modified="2023-02-22" version="1">MDAVATLFALISIIAILGPSTGLKCKTGAAIAAENSTVQECPEGTHYCVTIACSRANLASTALIVWTCTDKDNKNCSAEAKPMVENQAQETVVSCECTFGEKDKDWTNAEFALPQPPEQNATAESGELTCKKGQFDAKGLGNTYTTLCIKGSKYCFAAKCTKEGHYFDTWGCTSVKNSTLLNKALHARCNYSFGGWMVQRGNENLIIPAFLAITDPPMKNWRTGKDLSEKETQDVPLQISPEGECNVIYAKSIHKIAAEGGVVPDMVKLYFNGGSNDESRKMILNICVPRADGPEETCKDGLIFCFVGQMDPENAPVITQFQLKNYVKNNKIATKCENAQAKWHEPEFDGKKLHGFQIAHVGDKLMLSSSTSLETVTCNAEDGPCCEIRLGEPGILGGYVVGQRPNESDTFVDKAWRGGLLRQEDPVSALTFDLLGAIPQGGGFGIIADKCDMQITLEGEGLLKCLGKKCEDSNPEKNVAKTLAPKEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRR1</accession>
    <name>A0A914HRR1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRR1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3112.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3112.t1"/>
        <property type="gene ID" value="Gr19_v10_g3112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3112.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33222" checksum="6623C5E3B41F239F" modified="2023-02-22" version="1">MEETPHKIFDEIFGEGWWDNDKNEEWNKLTLEHNFHHQIDRQKTKIGQIEPNSTDQLGQIEPNLTDQLGQIEPYSTDQLGQIEPNSTDQLGQIELNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQNPPLTESDHSDNAKNVEEITSNEKQKFDQMKAELKRAGFKNSYPTQINETVAKELGITDRTIYNWKRKLGQTTPQHKYPHNEQKELMKRYYEIKGKNSKIRDEDIAKILKIGRTTLRRWQSQFKREQFYQNSVDGHFVEENAAANVQEIENSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS09</accession>
    <name>A0A914HS09_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3201.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3201.t1"/>
        <property type="gene ID" value="Gr19_v10_g3201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF10">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3201.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14031" checksum="06814FD9F22DE3C0" modified="2023-02-22" version="1">MGVSAIKSHVENKFHKQIEEEKRRNATIENFVRDKSTSSTLDMQIAAAEGTWAYHVANHHHSFASADCASSLFNGIFPDSHIAKRYGSARDKTRAIIKGVLSPLSMKVLKEELGQHQNFKKFGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUI0</accession>
    <name>A0A914HUI0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4119.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4119.t1"/>
        <property type="gene ID" value="Gr19_v10_g4119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000291">
        <property type="entry name" value="Transmembrane matrix receptor MUP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000047">
        <property type="entry name" value="von Willebrand factor A domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056590">
        <property type="entry name" value="Mua-3/Mup-4_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057353">
        <property type="entry name" value="TNFR_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF40">
        <property type="entry name" value="TRANSMEMBRANE MATRIX RECEPTOR MUP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23427">
        <property type="entry name" value="EGF_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25478">
        <property type="entry name" value="EGF_Mua-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25314">
        <property type="entry name" value="TNFR_nem"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2319"/>
            <end position="2344"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="539"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="589"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="642"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="701"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="744"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="790"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="839"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="899"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1298"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1349"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1399"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1450"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1603"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1651"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="13">
        <location>
            <begin position="1802"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="13">
        <location>
            <begin position="1976"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="2103"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="2151"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="2258"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2425"/>
            <end position="2447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4119.t1"/>
        </source>
    </evidence>
    <sequence length="2447" mass="269386" checksum="322E39E890AD6D58" modified="2023-02-22" version="1">MRHNDSTTKGSSADSSTVLKSITVISQSSDQSTTDDVVSISNKSRKSSTTISSLGERPNGLSYAQILITFLKGMIGPGCLSLPLAFRQAGLWTGLILVIVLGFLNLRCMHKLVECSQRLSKKKGNSFLSYGSLAYETFSNSFAPFKRYNRIARIVVNASIIALQMGICSVFYVFCADHVREFFAFEYPTVNYSKPIWMLLIFVPMVLVNFVRSLRAISVLSSIGNIICIVALTFIFQYLVRAEHQNLSEFPTITNFDGIMAACGAILYSFEGQAMVLPLENRLQKPSQMVGLFGILSIGIAVVSAIYSTSGFLGYVTYGAQVKGSITQNLPQNEIQFVLVRLLFTLVMFFGFVIQMYVIVEMLWPEFVKLLKKFCPKLGDDGGDENEGIKTKMLCVELLFRTMLVAIAMLIGLACARFGEYYSAGRCHHGNAFGTDFPRFARPSRVFAGPSATAQHPAGFLAAHRRLSKSLLLFLLIRFTPLILPLILCVTSAHDRETYQTPPECDVNDPLSCSQQKHEVIGIWVNIRYGRLPDGRCLVINECQNSKLNECSPDAQCIDQAEGYSCRCKPGFADVSPQNGKPGSACRRQQNECSSPHTYGVDCDSNAACVDTGAGYECRCHPGYTDISESFSQLPGRKCVVAVNECEDRSKNDCSENAVCTDAKESYTCACHPGFVDASANVGKYPGRICNKPHEKLHDTPTNECDPNQSSPCQAGQVCKQNSGGRYICQCGEGAALVEGKCQMIAACQVDPECDKNANCINVLGSYSCQCKPGFFDVDSVTPGRECKPLSNECADRHDCSPLAKCVDNKDGFECICNAGYTDVSSQIGLRPGRKCVNSSNECAERSLNTCDENADCIDTPQGYSCQCYSGYVDVSSNAHLPPGRVCTVQTSCPKQRTDLIFLIDGSGSIGSQVFRNEVLRFLKEFIELFDIGLDNTRVGLIQYSDQIRHEFNLNQYSDKQSLLQAVDHTQYLTGLTRTGAAIQHMVSEGFSERRGVRPLSEGANRVAVVITDGRSQDNVTQPAIAARNHQVNTFAIGVTDHVSASELENIAGSPNRWFFVEGFKELDMRLRSLVQKLACPTPAHTPHETIGGCNPDTQTGCDRALGQICVLIDGSPICQCPTNFQAHPRTNVCGGDLCNPDVTTSCPYPEYCQRTPLGNYRCVCPSAYARDSQTGDCVSSHVPLPPAPPCPAGKMLNARTGKCLLPGACDPSDANSCDLRKRERCLPTSSQQPSPPQPINHIRLPAATPAGQSYKKHRDMETYETRNPIRYVLSQTPDFTCQCVAGEKRHPITGVCLRNECLRNEDNDCDAHAQCIDTDEGFLCVCLPGYMDNSTDQKRKPGRVCTKTENECLLGTARCSPYAYCIDTPESYVCRCKPGYIDFSPNPQYESGLDCRPLLDECRTGQHTCHRNATCHDTADSYTCQCKPGFKDMDELRNPGRNCQPILTPKNPCDDGTHNCHTYARCRATGTLSYTCECLSGYEDKSPSEKPGRFCAPKQPICLDKMKMDCHQYAICQESNAYPEGFTCHCRDGYVDKSTDKYRKPGRICQEKVNYCMDRLLNDCDVIAFCEELSDGYNCTCPAYSIDQSPVPGKPGRKCKLLKNECLNPAENNCSRFADCIDKTEGYECVCRAGFRDETPAQPGTSCRQLINECKFSGMNDCSPHANCIDQPDGYTCVCKPPYVDEGSKQKPGRICCFNECANPKDNDCDKNNSICEDLEEGFTCKCKPGFYDAGQLPGRMCAAYKEPTSTPVIVEYNKNCTAQCGDECCQTELGEVCVGGAKCKCFPGLSRSKEGEKCEAVEKTPLLFRLVSEGDKVLLFSSEYGTSSSPSYVEFASTFSQDLGKAVSSTLYAPRYILTDINYITQPNKFNSSWSDGLLVNFTVETRLSPAGRVDACDLWNALQESIQKTNGAVGGGKIQVATDIELLSPCPKTTAPCGGLPCRAELGEICIGGNLCGCPPGQKRAGPDEICRQVIAFTFPFWVMRKYQYQLQYNESFANPQDSIYKQFVTSFENGVRQSYVKTPLASSFVISEVHDISPPSALNGSWDEGVLYNATMYFRVGKAPTAQIAYNTLIRWIIDRNNFQLGQSGLFINLVQPNPFGPCFKNDCYPKGLCIETGPNSYRCECSNGYRDMLVANPGHQCVSLYGINECENKTLNECSEHAQCFDLEYLYRCECYRGFKDASPKASVPGSVCVTDFCADVNFCSSNSTGENLEDSCFCRCKPNFVDLRHNTTETERTNAGLQTNQYCLLLVDINECLFPGLHNCSENAECINLAQGYTCKCLGNHTDENPQLPGRVCAGTALPIKEPQSGGGIFPWLLPLLLALLFLLLTLCCCLWALSQMRWLGGKKKAFDALDSRASDESLYGQALTIPRARLDEDMGSMASSEYTVREEVERRVTTEVTRTEEEVVGGETAFAEEEQVGDKSHTFSQSHAASYYGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUT2</accession>
    <name>A0A914HUT2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUT2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g487.t1">
        <property type="protein sequence ID" value="Gr19_v10_g487.t1"/>
        <property type="gene ID" value="Gr19_v10_g487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g487.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8127" checksum="DC5FA4D45B103DB0" modified="2023-02-22" version="1">MGRVKTDESWAIKKKKRINADLIHLKEFRFPGIFLASGYIPGMDEHCIDKTMENIDKYFHKNGLKRENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVR3</accession>
    <name>A0A914HVR3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVR3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4615.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4615.t2"/>
        <property type="gene ID" value="Gr19_v10_g4615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF4">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111171" evidence="2">
        <location>
            <begin position="25"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="147"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4615.t2"/>
        </source>
    </evidence>
    <sequence length="756" mass="82089" checksum="3A71D565CF5F7F8B" modified="2023-02-22" version="1">MTKFFVQFSTLLLVNLFLSSSSSGADEENNTVKQEQKQLVLNRPDIAFCEGSVSAFFVSDNVSVRGANASATIFESNEKQCANLCAENRDNRGRSLLCGSALYENDTRQCKLYRKASAPDGELKRFAADGRRYYEKFCLTDDLPADCAFTHFLRVDDHILKGYAQSTTTVPTMADCVAYCMHEREFECKSVMYFYEEGECITNMESATTAPSDFQRPEDEDKVVFIQNGCLRPGASQNASPFAIEDQKDTVAADEAVTTTNPAVTELPPPSQPPASPEANIAVEPSTTTTSASSTTTTPTATTSPLFSFRALMNKDNDEAAAVEKTQKLEENGPIAAEAKIVEAQVVGAQLNDSAEQIFGGGIGTARLHPKHNDESTRQYGAKTIEKIGTDITSTGSAENLSSSGGANISTSGIRLLNRKGPESTKRLHLKLIKDHQRARPNPSEALDSSSSSSPSTIVPLLLAASQTETAAPVPSASTLPPAPTLNPVPQATVTVAVGDSSEERFEGSQGYFSLWGPWTPCTVPGERRVRRRRCLDLRRCKGSLMQVDYCPRDIPAVEDDEVQAGAAEVQQAPILTRPQPIQVAQLQSQQQTLTPPQGQIQEVPKRNPVPVDLATGNVLESAANAKGNGAIAQPPAAQPEAQKAVETHSEPLPAGAPATRPIEQQHEQRQQQFQPPPPPPPPQQQQQQQQQQQQQQQQPVIVEAIWSPWNGTCQHFASSQPCREGKVIGFEARECIAKDPLMCKGPFFRYCTLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVY1</accession>
    <name>A0A914HVY1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4269.t4">
        <property type="protein sequence ID" value="Gr19_v10_g4269.t4"/>
        <property type="gene ID" value="Gr19_v10_g4269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="486"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="1022"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1280"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1314"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4269.t4"/>
        </source>
    </evidence>
    <sequence length="1501" mass="169650" checksum="6780425043E6CB9F" modified="2023-02-22" version="1">MADLVQLLQQLLTAQAEQQNQFSQALQAMITPEKQNAELFSTINTQVSEFMYSPETDETFHTWYERYGPYIETDGSALPDTMKVRYETFTMRKAPSQSPLDFATQVSASCEKSKMDLTRDEVKSLIFTTGLGEEDRDLRERCLKLMEDARQKGAAIKFSALVEECRTVLTLRSSASALSHLAGGSNSVTNSISVRPQRVSERVGRQQFKSPNRSRHNSVNQHRSPATRTQPTNKHHAPPPYPCRWCKAMHWMSDCPKRPNGPNYRRPAQRGSEWRSPHRTRDGSNKRLDSMTVLSMDSDNEQWITVKCAINGNMVSLMVDTGSRLTVIQTQLWEKLGRPPLNGVKRKGRSYSGAEFEISGSFLCSVTYSGVTLELECFVTPQGILNLFGLPWIRAFEHALHRPIATTLPPEAVSSMVTAAPTNAGDLTSHLKSEFPQVFSEGLGKCTKMKAHLHLKPDATPVFCRPRPVPHGARDAVDAELDRLLKIGAIKQIDYSKWAAPIVAVKKRSGDTRVCIDFSTGLNNNIELHRHPLPLPADIFYGIRGTSVFSQIDFRDAYLQVELDDESKALVGLNTHRGLFQYQRLPFGIKSAPSIFQKLMDELVAGLQGVFVYLDDFVVASNSVHEHFTALHELFRRLDQWGMRVKMSKCQFLCSKLKFLGHVISAEGIRPDPARSAAIRLMPAPSDIQTLRAFLGAINYYSRFVKQMREIRAPLDALLKKDAKWDWGSEQQQAFEKAKQILQSDLIITQYDPHKPIVVAADASRYGNGASISHTFSDGSEKFRNFSRMVYGRPFTLLTDHKPLLSIFGAKSGIPIYTASRLQRWALILLNYDFKIQYISTKNFGQVDSLSRLIAVQKEADDEERVIASAEINQNLGNDTEETDFVASAVDYVFHSNIEQLPISALEVAECTQHDEVLHQVSDHCRTRWPKEAASSSLAAYFVHRAKITEVQGCLLFGGRVIIPTALRRRILTYLHFTHPGVVRMKSLARRFVYWPRIDTDIERWVRDCPECALSARTPPKVPLRPWPSAGAVYERLHMDFAGPCNDGFKYLVVVDAHSKWPEVIKMNTTSPPLLITQLTWLFSRYGFPKEIVSDNGPPFRSHDFSLFCRSRGIKQSFSPPFHPQSNGQAERFVDILKRQMRKCARNDKEWLQNSLLAYRSTPSEVLQGRTPAELFLGRPIRTILSLVKPSLRPVKHCATDQHRERMAKQFNRRHSARERPFQIGDRVMFLYYHNNKRTWTPGQIIGGSGVIWRVKAPGLDVVTIRHANQMRANPIHDIPIVPAEPTLPDQANGTDQTTTQIQPTRRVRFADEQQPQPNEAQTDGEQPIRRSARTRTPTRFLSPDASKSKYDLGSTVLPADPLLYRFNEVQDIHIAPPTDSPLLQVLSVYGPRVFFHGFSAPTFRPGVSAPGVSAPGVLPMTTLYGPALKELIHEEFGDGIMSAIDFKVDVQREEDAERILKTGCDLWLTTRSTPPPLNPSTAVDCLSERQRIRSFWRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWQ9</accession>
    <name>A0A914HWQ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWQ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4857.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4857.t1"/>
        <property type="gene ID" value="Gr19_v10_g4857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4857.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11790" checksum="68318F7672C98F84" modified="2023-02-22" version="1">MLSCLWPSPSSLNCSRLTQSRVNIDRFWIGAISVLLLLSRLISCNRLVARLEPLDMELRRQVKALGSRLKTSVKRMNKTFFLISSGRLNIDRWKTKTEYSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWY5</accession>
    <name>A0A914HWY5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWY5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4788.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4788.t1"/>
        <property type="gene ID" value="Gr19_v10_g4788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036803627" evidence="1">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4788.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15301" checksum="B48F7FB4E135B4D0" modified="2023-02-22" version="1">MLPNLLLLLLAVFTSVLHQPMASLSSDADSSNPIRRLMQRRHLVPGRGIHKEQWHSNVHPGYLQWEKDKFHEALGEKILPKSSRNLMDPKFLGSLEPRLLKSSTDGVRTTSDSEETKWRNWLRRYFLADKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX98</accession>
    <name>A0A914HX98_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX98"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5326.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5326.t1"/>
        <property type="gene ID" value="Gr19_v10_g5326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5326.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26742" checksum="DE5E8A527F9FFD59" modified="2023-02-22" version="1">MRTFIDTFDAFCPPNFVRLYPRVFSATMANYVKDRRGIGEYWHWHFGHLSRLGDNPSQHHARQFPIVSIRLLIRLIIVSLIVVTLSSPIFGSIATGTGRIFRPSRSFTANVLMEEKTGTHFLPYQTHPTMKGHLFSNDATRKLRKAFQKILVPFILFEEKQSEGNGIQAIEKYQNFLCIILYVPLLVLFILYVLVDGTRVWVASFRLVAVRWAGSPMHSGKLAHSATNYVAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYB5</accession>
    <name>A0A914HYB5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S23 mitochondrial conserved domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5230.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5230.t1"/>
        <property type="gene ID" value="Gr19_v10_g5230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023611">
        <property type="entry name" value="mS23_dom_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019520">
        <property type="entry name" value="Ribosomal_mS23_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10484">
        <property type="entry name" value="MRP-S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS23 conserved" evidence="2">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5230.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14402" checksum="A369B90744768C61" modified="2023-02-22" version="1">MFSHLTRAERSGSIFSRIIGLISAGHLKWEDRPIWFDAYAAHPPQNEPNWDIIMPKREEALPKIFYHEDIDRAKRLLESRNEEPKQSAPIDGPSSRSVAAPPAVCSSPARSSPLPQRFPEDTKKGNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ61</accession>
    <name>A0A914HZ61_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ61"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6015.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6015.t2"/>
        <property type="gene ID" value="Gr19_v10_g6015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057618">
        <property type="entry name" value="Znf_POGZ/Z280C-D-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25429">
        <property type="entry name" value="zf-POGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6015.t2"/>
        </source>
    </evidence>
    <sequence length="684" mass="78816" checksum="BBCD2B09E97BACE1" modified="2023-02-22" version="1">MYPQISKHTNKRARIDMSPQSGTHIPSNDHIGVMSRFCNSYIEASNKRVQSGFGVIKEEFTGQFQNDVYKRLGPRPKLPPHPHPIYRAVPERAACSKVMRSAPLPFRVFLLNYTPYSSTPLLFYQSYQLTRCTFQSCNKRLKNNVMFIYHIWAHVAKQKPAENEEQFSNLQNPLAEHNRAEEEAKTDDQRTDVSRLHTCPECLLEQPTPYRARLHYHRVHKRGKRLLLDSKPELHVCNICEQVIDTKNMQHHIVAHELPNKRKLDLPYGCRVGGGKCQFRTSNRGVLLQHFCNKHVGTHVVLCPFCLMTFCVPPTHKLDSMIRMRDFVRHMIMHDEEKSRHCGHCVIKVAISQRAQMDQHQEQHTKNGEHKWLQWHMEHLDLNSIRPGSSHALISSDMISQQCVECGQMVNNLCRHLGIKTKRCKFCSFVTRCARAMDRHRLLSQCNPSNAMRRPFAAVAGWTFSVDNISCSTFSPSSSLSSPPLQQFSCAQCAFCSVSVQALAEHIAAVHATCLSAQVLLLDKNNGRQQVLEEQMMLNRMDEDGQGGDKMEQDSKEVGKDELHEAELFGLLRLANVPIDDDGHDDDEDNNEDKQQRFSADKQAELRDWLSEFLPLARADELSQREIQPQDVRLLKQLMKMNRSDLSPDEERAQRIAEEKHEFRVKMCLMHDDFPKLDLKTISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I179</accession>
    <name>A0A914I179_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I179"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5932.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5932.t1"/>
        <property type="gene ID" value="Gr19_v10_g5932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5932.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14697" checksum="1AEEB01A869B08AD" modified="2023-02-22" version="1">MPKTTENGIPPIPGVHHPCLGPGILPIFSLTPIPSGESTVLNLGGTVRFSHYNVTNCIWKRVRPNLSSSSTGTTVERRQLTKEDLIFRRVRTSADFPPPLNPLLFHVDKQQTPGGLQCHADKNAHFYRFGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2X4</accession>
    <name>A0A914I2X4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2X4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6368.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6368.t1"/>
        <property type="gene ID" value="Gr19_v10_g6368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6368.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13806" checksum="8D58DC21EBCF6DA7" modified="2023-02-22" version="1">MIEHGLPEDRERIVRSLQGDIMKYAQDKFSKLSRDRNGIINEILAQVIPLSLHKYGSWVIECVLEHCMEQQKRLASHTNYGHDPTAHMIEHGLPEDRERIVRSLQGDIMKNACAHCMATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I363</accession>
    <name>A0A914I363_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I363"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g640.t1">
        <property type="protein sequence ID" value="Gr19_v10_g640.t1"/>
        <property type="gene ID" value="Gr19_v10_g640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g640.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11221" checksum="0570E5957F33183B" modified="2023-02-22" version="1">MIEPQSPEGADPFTLYSSGHHNLPKEQVLSPFILLGSHHNLPKEQVLSPFILLGSHHNLPKEQVLSPFILLLLLHKWSFWPVGADGVVFGTPSASTQVGSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3N8</accession>
    <name>A0A914I3N8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sugar transporter SWEET1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3N8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g653.t1">
        <property type="protein sequence ID" value="Gr19_v10_g653.t1"/>
        <property type="gene ID" value="Gr19_v10_g653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000004">
        <property type="entry name" value="Sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000010">
        <property type="entry name" value="Sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF246">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="297"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g653.t1"/>
        </source>
    </evidence>
    <sequence length="567" mass="63305" checksum="E5DDA974C975A2A1" modified="2023-02-22" version="1">MASSPFLNLLSILAFVTTVGLFFCGIPICRQIWKRRDTAEISGAPFLMGVLGGTCWCVYGYLKKDHTVMYVTGAQIVLYSIYTVFYWFMTKKKLMISIKVATLVAICASLVALVHFFDHKVFHPLGIICMTLNTMDFAAPLAGLKVVIRRRATSTLPLPLCIANFLVSSEWFVYGLLVWDFYLITPNGIGSFLAFCQLILFAVLPRKPLQRAPILRLIDFVRNSCCCCCIDKTLDLESAAVVTAEKKSSAIDTIGIHRMSSRMSNKHRWSSRMITNVVGEVENVIQKVHGDQFGYKLNKEDEEGNSTDSGTLTPVDEKPTTTVAVTAASGGGTVQLQGVQSGTPEPERKMEDEEQLDIDDVDDDDDQSEEDGEHAEYDGTAQDGIIAADLAFPLTIRDPEQLLRLSRQCQSDRLKLHKKQKMAKKGGSGMFGGSLQTGHFRAMRRHAQQSTNADGLPTIDELSTQLQQHIKRAASAPNICEEAKTMTTLSAPVVRIRHKFWLLQTAVKHEERGGHWTLRTLRLKRRNLSGFFFDDCEDPLPPTVLCEMSPRRVDNLSTRHNKSPNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3S6</accession>
    <name>A0A914I3S6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3S6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7239.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7239.t1"/>
        <property type="gene ID" value="Gr19_v10_g7239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7239.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15083" checksum="DCC52A7D4A573FE4" modified="2023-02-22" version="1">MLVVVRRVASELYKALCKLGDTVVYPILPAAAKPVWNHAAGPKTVFFWAPTIKWVIVFAGLADLTRPADKLSFDQYAAVTATGFVWTRYCFMIVPKNYYLASVNFFVGSTAFVQLLRIAHFHYSHPKPKWEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5B2</accession>
    <name>A0A914I5B2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5B2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6754.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6754.t1"/>
        <property type="gene ID" value="Gr19_v10_g6754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037033295" evidence="2">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6754.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11041" checksum="AD9488301B0F457B" modified="2023-02-22" version="1">MKLYAAVLLMVVLVILALSEGGDQQPEKSKSTNYSKVMKPKRTEQREKTFPTGRAEHFLIDLNQTNKMLDQHRHPLPQISRVLSNTPDQQHRHPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5P2</accession>
    <name>A0A914I5P2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914I5P2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10960.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10960.t1"/>
        <property type="gene ID" value="Gr19_v10_g10960"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6858.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6858.t1"/>
        <property type="gene ID" value="Gr19_v10_g6858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000023">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000065">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10960.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6858.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36815" checksum="681B10B9EC22D518" modified="2023-02-22" version="1">MLNSRFAAILRRLPVPDIVMDYFLHKLFETHRLDHEKFGLKPKHGLFSAHLTVNDELPNRLCCGSIRVRPNIRQFTQNGVIFEDGTLLEGVDQVILATGYTFEFPLLEAGKLLPVEENDVSLYLNIFPPALHSHNTLGIIGLIQPLGSIMPIAEMQARLFFSAFTGAIQMPSCTDMEVHAAGVKEAMHAQFVQSRRHTIQVDYIEYMDTLAELIGCVPRLGRYLFNDPALFKALLFGPNLSYAYRLDGPGQWSGARQAIMTLRQRVEAGMRGIKLPEDKWLCPEATKIAGILPKGTKRQLPAELIRAFFAFLFSVLALAFTVWVARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I694</accession>
    <name>A0A914I694_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Orphan nuclear receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I694"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7289.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7289.t1"/>
        <property type="gene ID" value="Gr19_v10_g7289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052496">
        <property type="entry name" value="Orphan_Nuclear_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519:SF3">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="45"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="200"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="569"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7289.t1"/>
        </source>
    </evidence>
    <sequence length="850" mass="94741" checksum="7F845BD4D36427AC" modified="2023-02-22" version="1">MTTSSTEAVPVCNSASAADPSDARRATAVFASTDSNQQNASITGTALCAVCGEANAKMHYGVLACLGCKGFFRRALKKLNEYECLRDNNCTIDKQERNSCRSCRLKRCLEVGMDPAAVRPDRDVSGKQLLDRRRLSLSGSGSSNCNTSNRTNRGSGQHNNQRERCKGSATAKAAAAHGGGDAVGVEEEGSKNCGQRLPVEMRTMLMTLQNIEAKVSDVAGDASEIYPLHINTIREIINDPAKLRGRRTAIRYEPYRMARNEELCVIVYRRLIAAIDWVELLAERMGGLSTEDRIALVKACFGPLTLFKCAARTAIVTENENLLCLCNFAYVPREISKAYHDAYHLDNGLVERLLNDLVGPFRRIHLSEEEVVCMSAIIVLNPMARDLSEQAAGLCVQLRNRIYTTLYQIVKVVECRAECNPNVWFGNLLLYLPIVASLANAMCENLRFAQTFSTLGGIPLLTSLFGCFPVEPFAVSELAALGVGSKGLVKDGTGGAKGSTGSAPKKALKERGTQTNDWTILHDYISPARKRPLVPTSSLTEESMDDFRLLKAPCSYTLMEMFDDRINEEEGMEQQQQQQHPGIDNAVDRRNSDGVPPFENVHKATATTTTSSNSNRTSDNRESQMEAVLQQQQQHCWHVQPPSAQIKQLHLYDGTPTTQFGTHPLTVPRPATTFNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQGAAPNYAAAYMPMLTQQNHYPSQYYAHFSPAVDYQFWHHNNYTYLPPSSSFWPPASVPIQFVNKCPTGIFETAPRTAQNPHIAFSDNCPNNSLSSQYAPNYCPNPNSSCPQNYISQNILPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6C1</accession>
    <name>A0A914I6C1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6C1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7307.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7307.t1"/>
        <property type="gene ID" value="Gr19_v10_g7307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="101"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7307.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29979" checksum="C2ACEDA1C63D9952" modified="2023-02-22" version="1">MNFSCRITLLPDCQMNFCNFPHDTQRCSLYISSIAHPKSMLDFHWEPRPILFPRRVSLPDLRIKKIADTICQLPGKLIPSSCLALTFVLKRDSARYVAERYMPSILAMLFSWVAPYVPYNYEEVRIITPITVLLTLVQMEKGNQEVITSYLTSLDIWFVVIKAFTVLSLVESLAVMAYIKKGRAVESEAQRAPNEYRRELLQAEVKRIERLYHRLDHLSMALSPLAFILFMLYYVHFVAQRDGRSCVERHAEDGRMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6L9</accession>
    <name>A0A914I6L9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ras-related protein Rab-2A</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6L9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7240.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7240.t1"/>
        <property type="gene ID" value="Gr19_v10_g7240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000275">
        <property type="entry name" value="Putative ras-related protein Rab-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7240.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22919" checksum="6898DA8360A39FA3" modified="2023-02-22" version="1">MLFYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHSNSNMVIMLIGNKSDLEARREVKKEEGEQFARENGLVFMETSAKTAANVEEAFIDTAKEIYRKIQEGVFDINNEANGIKLGPQHPPSSPSSPGGAPLGRASNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I705</accession>
    <name>A0A914I705_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Topoisomerase 6 subunit A/Spo11 TOPRIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I705"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8086.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8086.t1"/>
        <property type="gene ID" value="Gr19_v10_g8086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="2">
        <location>
            <begin position="58"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8086.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="39950" checksum="A48C3AF07AF732D6" modified="2023-02-22" version="1">MDDDSVFGAQRSTISAGGGEGRHLSAAHRRTIPAQIPTWHFAHGAAVIQTFAHVNSSIGCVEIFLTYKYGSSRSIVEAGAFHLPRLRWLGFLPSEAQKLPIPSNQFSEKDRKRIERIAQRTNGHGEEERSLFNYELSVMLNSSQKLELEALCSINYLSTVYLDNKLLPLNVSVAQPYDGNNNVERDQNGGDQSDDFGIDLNDQDDDFGGDQQGAFGSDYDFGGDQNDDFGSDWNDECRGDQNDDFGDDQKGAFGSDHDFGRAAPLNGTEKRDYLVNSLCPLPNSTNLPTSTSKLAALCLNLARAPIPHPTDKANPGEYQFWLKLVQVSIGIAAVCVAIGVLDILEHLCRRQMNTLSPNFIFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9M5</accession>
    <name>A0A914I9M5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9M5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7891.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7891.t1"/>
        <property type="gene ID" value="Gr19_v10_g7891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="571"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7891.t1"/>
        </source>
    </evidence>
    <sequence length="815" mass="93449" checksum="90384343DD9CE23A" modified="2023-02-22" version="1">MDYPRINEQELKFPIPCGIIVSGPSSSGKTQLVLRLLSCADEMFAPPPKAIVWAYGEYSAQIPELERQGIIVHAGAPSDEMLNKLPKPFLIVYDDLMGEIDAKKLADLYTKKSHHNNFAVIFLTQNLFDKAMRVPRSNAQYIFLMRAPNDMLSIRNLATQIFPREQGFLIDAYKQACAEPYGYLLKQLIGQRVLENYEYLKTLGKTSSQKKIRHLLSRAGCEELLTLVEICLNILNGSFCLNNKQKQKIAPFANFIRKPRDICFRDEKMANKLILLPIEHYKGLVAAREKVEDDVTDQTNFGFVKQQFEKAKRKRAANVSEKSAEYNQQLRRYLKLRKEVKDKPVKVQLSNGMRLMTKPPATGVQLKPGPEEVEETIVIGGSEADDDEPAAISSPKFSTPKEVEAGPEPRVSRKRDLKKQEIMAKKEKLLSIIKSNPTRFGVNERDKIINPSTGREFIDFDLTWAIERLVNPRPENAPSPSGTRELTKKLLQDPTAKQLINPRFVGSGKMEKINKIYTDPSNPGEFAGAKQLYTAVKKKHPGVKRAEFDDFLRGSTTYTLFKPKREKFRRLRTIPGGFMTDVQADLADFQALSRKNSGNRYLLLAVDVLSRRMFGVPVKSKKPAEMKRAFEELFGQMPKLPETLYTDRGLEFVAKPLKEFYAEKGIKKFETSSKKKAAVAERAIRTLKTRLYKYFSAKNTSTWVDVLAKFLAAINNSVCRVTGLKPYMPNYSDHVYTVDERRSSNPEHYFVKDYYGTKLKRKFYLPELTKVKVDKNTLYRVEKKYKERIRDGQKEMLVKFIGFSEKYWVTKEDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAJ2</accession>
    <name>A0A914IAJ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAJ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g840.t1">
        <property type="protein sequence ID" value="Gr19_v10_g840.t1"/>
        <property type="gene ID" value="Gr19_v10_g840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="602"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="202"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g840.t1"/>
        </source>
    </evidence>
    <sequence length="806" mass="88633" checksum="F1D92342220CA1A3" modified="2023-02-22" version="1">MKIVQIKHLQLSNYPSTTSGARSSPQNVGGVELSSSSSSDANLMPSQRPKRLPIPPSIREKLETDNPLNCKICLQIFNEPYTTVCGHTFCRACIMKSLQFSTQCPVCDSGLDTKKARICGTNAANDTTLNNVLLSPNYAVAALLEQQSKPPFGRTFLDHRDRVELGSETGTIEQQQQQISADDIHTERFIINMLLSDSHLSLDSLKRIEETLRQKRVEVELNDSQMRALLLHDFLEMMIEKRDQTVKQVQAELELLKQDRQKVLASLSDQICASPLHRLVPDSSTSGSASTSATSDQPKLQQIADSEESIKTTASTSTAIGVGMHKVQTVPDRMSQLRHRMLRHGPSLEAAYLSQRLPTSGQKDLEMQSVGAVATTDGLNDFSLLLKNMYRYGDVKVLTTLNYNIESYNQPSIVSSIEFDKDGDFFVIAGVTKMIKLYDFNALMDHCCSTGDAEEAGIATNTAPSFLHQPVVQLRCNSKISNVSWNPYNKQMLASSDYDGTVQLWDTASAKCTRTFDEHEKRCWTVQFNSIDPHLMASGSDDGKVKLWSVMCPQSLCAIDAKVNVCCVYFSPKSRDQLVFGSSDHCVHLYDLRQMAKPLNIFRGHRKAVSYVKYVNENEVISASTDSNLRLWDVNTGKCLQIMRGHQNEKNFVGLATDGTHVICGSENNQLYLYYKAIDEPMLSFDFGQRCVIYPASQQPNNNNAPSSALPASLASASNASELLGTTDFLPAAAGNAHGISSGAASWQSLFGDFYGTVGGGTTSSSSTPNAGSNTGDFVSAVCWKRNSNIVLAANSQGQTFVLRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAL6</accession>
    <name>A0A914IAL6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAL6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9043.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9043.t1"/>
        <property type="gene ID" value="Gr19_v10_g9043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="61"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9043.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20356" checksum="BBE96A9B9761DC93" modified="2023-02-22" version="1">MALQPAAGGDVLTNKMPNSPNFSNKNINLFKEDELNKKQTPQMPSSAGIDYSRAHSWGTATLAHLLKDPLGCQIFRCFLHETFAEENLLFVEAVESLRGVKDPEMIRKGISELLKKYGVYVNLSCVAMGKLREATTAKMPDFIDLEVAKKEIYTLLENDQLPRFRRSELYQGFLKKILSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB44</accession>
    <name>A0A914IB44_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8954.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8954.t1"/>
        <property type="gene ID" value="Gr19_v10_g8954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8954.t1"/>
        </source>
    </evidence>
    <sequence length="879" mass="98475" checksum="44D1AEA74A8D9B3B" modified="2023-02-22" version="1">MTSSSPKNAGGIEVGGKNENCRTSEQMKWAAVQVQSKDKSITYASFLRYEFFTTEAEPLSVSVSGAEQCNPTVGDMTLAILPKHSRLSLEQLAAQFDLQVQQYLDTDSEPDKLIDIDGQQCWYKPVEHLGEYNLLLHPKLDDRRQDGGDVDRAAKLGFFPLSEFISDKKQHMPKSLHKVREFVLSERIQSCLQSVEQFELLLPAAGQSQNKYAYTLTKDQLNKAKQMLENLESEKAAIYAAIRNFVIFLDRGESVEPQLRPGTSFDEAGTEEFGQAIQNAVDQFQTNGASLLKLHDEKLLPKIELIRRLESEGVHYIGHGERRMADVFRGNEDSDLASALHFVLLYSQAQTTPPDVAGSLHKQCLGQLFEMAGRGKMCTYIDLEVLLSYDNSALEHGGLPEGIRALDGFPNIDSRLVKMRGPKLLTADCVMEECDKLKKCIARIDDSQLTKVGAVPPADQKKHSCSLPCPLCKSNGGKCQNDDFYWGCDDCGKMLAFVNRENVPVTHFYCDCGATPVEAFTFRCLDVQTHGDKFVHFAPNELAIELREMEAKGILNILLLGGNGVGKSTLINALVNYLKHPTFKDAIKADKIEHVIPAKFNTEEYDADGCLVKREVYLGEQSEDEQLKTGNSRTKWPNAYIIHSKEYKIRLIDTPGIGGTDGEVKEDNENFHKTLNFISTLPELHAVCILLQSNTRTEPALKYCINGLLTYLHKNAAPNIVFMSTFGRGAFYKMGETRELLQEILNPIEAAHNLSIPLHRNRIYCVDNEAFKHLCLIKKANVQYSEKEMDNISESWSRADQEFQRLFKYIPKLKPHRTLETMSFAKDNNSTAPPKVSGHAIDTVRYYAGKVPGIGRFVKSQAQPSSSSSTSNRAKKNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC01</accession>
    <name>A0A914IC01_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IC01"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8479.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8479.t1"/>
        <property type="gene ID" value="Gr19_v10_g8479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053015">
        <property type="entry name" value="PH_domain-containing_M2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057288">
        <property type="entry name" value="PH_PLEKHM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46556">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46556:SF1">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23142">
        <property type="entry name" value="PH_PLEKHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="7">
        <location>
            <begin position="57"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="817"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="765"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8479.t1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="119509" checksum="AE5F76AC470A7E0A" modified="2023-02-22" version="1">MFHHLAPTGLPQKSALKPTRAQHEQIERNINGAVDEILSTNGSLGSQSESKRPITYNLAHPDTVTLLKSLDAFFAHGLLKSDKCYWAFTREFIPSAERVEVRVRWACQHRRALSLAWLKDSLNRANLHFQMLSFISCADALKRMHYDRNACMRNMALLKRMCIRVDRLAELQFNIEPPYVFQPEDTPIALPTAQHTTTTASFDGTMSPIGSSNSSLLNGVANAVQRQQLVTPNMPLNIRRRAAQNSAMSKSFVGSFCEATSRGSFLDGLVDDLPEVDLSTLGPSTAEHVVRSDREQSYILDQMLRHQRKSFTNFDTLVADEEEEEEEKRRHKLDMEQNQSVRSYVPEDPETTAGQHVPARHDDDATVAVQQQQQQLVQKRPEDEQQQQQNVVGQQMSVAASAHLPAVPSCSSLTSSSAELKFGAGSSTTREDEELSELDNETSALIEGEVLLEGHEKISLGLQVCVDDVETVQHMFQVFGGHAAGQPLVRYLLLTSKFLYLLAIDEKVTSAAAAGAFDVVDEREFGTISPASAVVEEWPAEAFEQNQQQLQQQHQLRPPQQMTLPVEAWKFKRLHLLPLCDLDHLTVGIDAQTLCFHSKRRKFRVSPHSGHEQRLLAVETGSRRLGKTIAHCVRRAVEQQQRVWTEQRQRRRRPSAGVGPPPTGEEEQETTAAGRAARDPKFTETRDRYSPAALLICAELAVILPSSATNGPPSPPAQLYVSTSHSSHLGLLLKRFLRQELGMQQLEVVHHSLVYWHQSDVPREQRRLDEKRHRQQQQQQQSRCSTDETTAPTSTVDGEGGGEKDGESMECYMYVRELYQRSWTWRASTNGEWRQSYVVLSGSKLYQFSDSTYKFAQRSINMRDVVEQVYQAELVNDENYVFQLDFRDDAQVGGGEADDGPLLGGLQFSCPSVATMQKWIGALSLALSQSGEQPLPTACMAVLTETHVVFAQEGVNCMVDGFMRALSAFHVHEIAELCAIRTEFNSALVLRRNNGLDEWMLFREVAELDRLVERLRQQWNLPVQECSAEENLLNSSFNQLFLHCVRLPDLWHCSESIATTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICH2</accession>
    <name>A0A914ICH2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICH2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9337.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9337.t1"/>
        <property type="gene ID" value="Gr19_v10_g9337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9337.t1"/>
        </source>
    </evidence>
    <sequence length="368" mass="43070" checksum="6543BC5D7FDD0223" modified="2023-02-22" version="1">MQRSKISDNFTKIETASKELPKLTESENKNIGKFSKKEENIFPKKMITYGGVVTPPGFFKIVVTDERKIKSAQCARLLENVMRDIPQKTGSNLEEFSECFKHFYTAQTNVDGEFEMQLPNSVQETIFVQILPLDKNKRLIQSSIEPTFFLQNVMKKTNWKNGNKDALYFYYNAIIEGKIDTMLSRWASQNYQPSEDEAFLLKAYFREVTEKLVELFTNGRIMQDDELNILYNYGNWLLKCQSEGKLEKTLAQIDGMQMLIKYQKNQNLLCLMLEQFLKRLPKLMENSKRFPKPMKLASKRLFKKLQEKPVYSTALKRLPKLMENSKRFPKPMKLASKRLCKKLQEELAYSTACYHPEKMHFSSTQSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDH8</accession>
    <name>A0A914IDH8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDH8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9217.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9217.t1"/>
        <property type="gene ID" value="Gr19_v10_g9217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036734879" evidence="3">
        <location>
            <begin position="18"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9217.t1"/>
        </source>
    </evidence>
    <sequence length="504" mass="58120" checksum="ABF6C48767E6F3B4" modified="2023-02-22" version="1">MKFYVLLSLLLLHNIIAFELHVQPSIRKATGNDVSRDEKLQKWRRSELQKLANIFAGKLLSDPNFANTQFVEQSASKYYLDVDSLDKVFKKMETNGLALRTQIYEEIKTAGLLEDKGDIKEVLRVSPIFKEMSQREKHNLRITDQKVAQKIQQTNMINGSKVSTPRQTHEWNLHKMTEEKAMFEQKYLKKKQKSKVYKEKGRTLKKKLESREKEISELKRSEMYYKVKSERLEKELENREKELNQLKKNEHLYSEKNQRMEKELAMKEKEITELKNGDVAATAPNRGGIFNKLFGGGAEEEANRVDTLNSTLAAKQHELHNLDRDISTKLRQLKNIEAEIGHTGTPIKLKKVSFADSGSISNHQQKMDQSFMNVITSKEKNDASAAENDEETSVIKTPRRIVTLTKRKPSRTSSATDYEADSETKAVDSKTPRLTLTKRNQIPDYEADSENEAANPKGQSKRRIYYDTSRQQSASKKHDDIYASRVGVLSPSWARKTSIKKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE05</accession>
    <name>A0A914IE05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9737.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9737.t1"/>
        <property type="gene ID" value="Gr19_v10_g9737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022:SF1">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9737.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16966" checksum="F2E8BA9D7573A86D" modified="2023-02-22" version="1">MLTIEKLSKFARGDVKCFRLGEAVHIRGLPWKILALLQSTPNSAERWLGLYLQCNGENTEPSWSCAGSATFRIVSQKEGKKDFIQTFSRRHSFFSKTNNWGFPEFMNFEELMDPDNGWYDAKNDTVILEVEVTAEEPTGIDDTDFVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFS2</accession>
    <name>A0A914IFS2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFS2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9463.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9463.t1"/>
        <property type="gene ID" value="Gr19_v10_g9463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9463.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7730" checksum="9B8B31A371460A03" modified="2023-02-22" version="1">MTWKATDIQASFWSGTQLTGTQLRRDAGGWDAVGRDAVGRDAVGTGCSWLRRSCRDAVDHAPCSTSSNLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGU8</accession>
    <name>A0A914IGU8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGU8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9764.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9764.t1"/>
        <property type="gene ID" value="Gr19_v10_g9764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9764.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11157" checksum="D8FE45C711FD6544" modified="2023-02-22" version="1">MLPYDHLQKGLLLGPQMDSSNSSSSTYTANFPAPIASNISPQIPTFYIGSYLFVSTVPIRNDTEFGSICHIQDGRPPSANRPACPPRPTRLLAKFPQQFGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IHD5</accession>
    <name>A0A914IHD5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IHD5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9930.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9930.t1"/>
        <property type="gene ID" value="Gr19_v10_g9930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9930.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="32493" checksum="C65188D9CE00133A" modified="2023-02-22" version="1">MNGAGPMVLQDPCCSPPLPPPPPPPSQDLSGVGGQPMCICTPDPCCMGPQMAPMGPQPFPSSPVGIEARSPVPALTISCICTPLQKSDCCLSPPPSPQMAPQFSPAPPLPPPQPFCVCTPVQQEPCCPPPQQLQAAPLLPPSPIPQQQPSPPPPPPLPSPQFQPSMSAGGGVPPPMGPMQQQTMPSTPHGNAGSFVGRAPLPPQLQATSIGGMGIGASPAGGGQSPTIGAGGIPTCICVPSRLGRGGQMPPCCKHKNKRKRRNREGEEAAESVKRRAEQAEEREDQRNEKSKNLGEKEEKAKMQAEKRPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPQ4</accession>
    <name>A0A914GPQ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPQ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10200.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10200.t1"/>
        <property type="gene ID" value="Gr19_v10_g10200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036710483" evidence="1">
        <location>
            <begin position="25"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10200.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39926" checksum="BC92CC222841A1B1" modified="2023-02-22" version="1">MKPMSTLLLFNFAVLLLLHSPYKHDPIILSNRADLSRQDIRGLVRKLKQLQHTVDEVSMFECANVHWRLLKPTQKAIRYCKQLLNGTDRFKRPANAQLVRHFSRLTKNATYCDEAHFERAKAGLAELLERDGSYTIDEQQVQQAIKEFILELKLSILETELTAKIAAFTNPCIYGKEFKQLSQAIKHELAEFGYIVEAWPKALKENFQEKLYKFVQFAREQSEPLKQTFWHKLDAISSKSKTTFEALKQNFYEWKKSAATQSPEAKQKKFGQIIWQTKQIFANFSLDMQNIGIPRHDIDEKNGHVEVFEQIIKIVQEEIESEKQEMNETFKFKMSNDYELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ47</accession>
    <name>A0A914GQ47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQ47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10308.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10308.t1"/>
        <property type="gene ID" value="Gr19_v10_g10308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036999596" evidence="2">
        <location>
            <begin position="26"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10308.t1"/>
        </source>
    </evidence>
    <sequence length="401" mass="42896" checksum="36C4552D74C09736" modified="2023-02-22" version="1">MEHSSIIVSLQLFLVLLVLHSSVKGSCCCCCDCCGCCCDCCCCCCGGSRNSNNAAATTAAAATGLAIGSALLASAGQAAIAPIDAAQETALGPELFPDGSTGRRNGQQLLVEIERGGTAGGVFFPGRRRRRRTRRFGKMDGINFDPMFPGAGGGQTQKSVFGNEPPGLGPGLLPDGSTGRKSQHDGHNNDFFDGMNFDGMHSPAAQRRQRQTHKLDKRHCGICPANECFCRQNCGEALKCPTKLKVIEIDSDSLQNYTVSRFLLGLIPKEVVQSKTKKSGRAFPEKVDAEHSSLSAEIDITSQQSSASSTSVSVEDNSSSPTDQKRFRPVSAVDDQQQQQKAEDLIARRLFLIPPVGSISGRMKREAAPLGTLPPPPLQFYKPTVPNPENADERLGVDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRG1</accession>
    <name>A0A914GRG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10616.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10616.t1"/>
        <property type="gene ID" value="Gr19_v10_g10616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10616.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13836" checksum="8FE0EC4090DF5894" modified="2023-02-22" version="1">MELYFEILRKKQHLLVQARENWTAKELKRVVEGILKVSPDKQSLRKPINELRTEWEPIDEKQTLHELGFTMKNARADDPAVLALVMSGDGNNPDLTPLSTPPPVPEAMAQTRQTEMEMGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS76</accession>
    <name>A0A914GS76_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS76"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g108.t1">
        <property type="protein sequence ID" value="Gr19_v10_g108.t1"/>
        <property type="gene ID" value="Gr19_v10_g108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g108.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39818" checksum="4E843EF64896462C" modified="2023-02-22" version="1">MSDHPRVQQQNLMQMDEVSICNDIWLCIFTLIEPAEVGLKMALLSDRFEALVDMHFRTRKWTIGNLKIAPSMDGVGDEQHIVKWRKNGGITKHFSLPQQSPPRSLVGFERISFFYIDHAVIAFVNRIQHLFNADATLNVDIRHGQNRSWNIVTQEIWPLIAPNIGGMIFDLGQLGHRASTLLSKCTKLRSICCSARFSDKLSNYHDEAVAGHALSIWIHTPLNECGHAKVLKFGKSCMPNIVRGMTEQLKETFLRDSTSVNYVVVLQLLSGITSFDLKNEGTRERLTIRLIGNNLLLIARSPIVRDEQQWTKWENEAVNMKAEQQKNFVDIHIGDMHIGPLSDAGPSQQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSU2</accession>
    <name>A0A914GSU2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSU2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10896.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10896.t2"/>
        <property type="gene ID" value="Gr19_v10_g10896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10896.t2"/>
        </source>
    </evidence>
    <sequence length="186" mass="20170" checksum="F08E86683039FE7D" modified="2023-02-22" version="1">MMLIEKNGYTFILQLAPLQSKCGMMMMTLLSLFILVLALCLCSSHGSKQNAAKLELDVGKKVETNGALAGKAENTTSTIIKRSCCCGCGCCCCKPCCCCCCNRCCSCCPCCEGCGWKWSPCCCKPCCCGCTGYGRRRMMRLRRRRDTVPKPGVPSSATSEALCRPETVTKCEFDNPLPVLGTTKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT16</accession>
    <name>A0A914GT16_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10951.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10951.t1"/>
        <property type="gene ID" value="Gr19_v10_g10951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10951.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="41684" checksum="35CD6E600A2CFEC3" modified="2023-02-22" version="1">MSKSTLQRYVKIMREAGGGTPNFQASASASGNPESLIPNKANNAKETMEEEANKFLAEARQRLYERQHEVAMQSVPGFDATPYLQNQLQSTGWTGGTNFSNASSQFQVQQPSSTAYYGGAMPFQQVPPMPDTLFPALQNYPFNQSAPLNSSTNFVPSQNETDSLDWSGGNSQNNEGTLESMIRTGKPGSSKNASQGFDSTPFLPNQSQSTGLTGTSNFFSPTPNTYNFNSGNPGSAAYYGGEIPFQQAPMPGTSSFPAFPNPFNQSAPLNSSTNFVPFQPGTYSTNFFGENSQNNEGTLESMIRKPSSSEAFSNHPFNQSAPLNPSTNFGQSQNETDSLDWSGGNSQNDDLYSVEPRQQKIEVLFNLLVKLHSGMIRGSAEEGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV60</accession>
    <name>A0A914GV60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase-coupling factor 6, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11631.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11631.t1"/>
        <property type="gene ID" value="Gr19_v10_g11631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.110">
        <property type="entry name" value="Mitochondrial ATP synthase-coupling factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036204">
        <property type="entry name" value="ATP_synth_f6_sf_mt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111357">
        <property type="entry name" value="Mitochondrial ATP synthase coupling factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11631.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25617" checksum="6463AF4600775A7E" modified="2023-02-22" version="1">MASFRGFLVRRVFSTSDVCMKADLVTNAYLSKIREVVGKQSDLLETSPEIKKQLGEQLNRLANKFNLPDADAVTKLNFQFESANVVSSVDALTETVDEQLKALKESRAIYEAEQADKKRAEQERLTSMSGDSDYANDFFPIPPPHIEAQQLAAAASKSTDCCPVSCRSQLVPYRLVQKATTDQSSGGRNTIQPLKISLGFRASAFLLERQFYNLSYQSLSNGRPDSSRGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV75</accession>
    <name>A0A914GV75_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11643.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11643.t1"/>
        <property type="gene ID" value="Gr19_v10_g11643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11643.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35522" checksum="A0BA826E22190FDB" modified="2023-02-22" version="1">MPVIKLSALDNTQLRKRKLAVPHQDIMLGVDVLPSGFTLSQSKTENSERIRPHRHGPRSERHLHPLSARPNCKTNSPTVKQTTKCPTSTRRRTPKNDERLPCLHSASNVHVKNGLDHLNSPENLEYGRPSMRDSANNKKAAIQQGQKPSIEVARHQKHRGAYKFSANKQEPNKIPWKSDLACRRTFQEKSPVRENRTSHPKPWIFSGTRRQPSTTPGPTRQSAFPQEPATNGKSTTTPSSQKQGFRPDTLDYRSFKFNQHKQTLELANSHRDHADKPVGLTRLQSCVQPTNVSRTIWRSRNSERQHFQQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVN6</accession>
    <name>A0A914GVN6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptide chain release factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GVN6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11618.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11618.t1"/>
        <property type="gene ID" value="Gr19_v10_g11618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide chain release factor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11618.t1"/>
        </source>
    </evidence>
    <sequence length="601" mass="66049" checksum="6EF2765EE473007D" modified="2023-02-22" version="1">MRFENGVHRVQRVPVTEANGRMHTSTVSLAVLPEPEKIAHQRLAAMLLKQQVDEATRRYASNRTLRVGTMERAEKIRTYNYKGNRMTDHRLKLTRHGVEQFLAGGEQLEKIGSHLYVGGGKTSATVRARRHVGHASLCAESAFGDRRKLEQCNSDTQKHSISWPFIMGHEGEMCSGRESRLMNGRTYSPVSVGSNCSDKASARSVVAEEPIQIKTTMSAARQQTVQNVSLVFLTLQQTVYPIMVREAHKMSRDKGQPSFLASAVVLNTELSKLMLSCLILTISYGSFTRFCSEIASAFFKNKRETMKVCVPALIYVVQNNLYFFALKRVEATLFSISYQLRILTTALLSMLLLHRVFSRRQWGALCISLLGVCLVQFASSSSSSHGGSAGASSSAAAHDEQFVGLLTVVVMCWTSAFAGVYLEGVLKQSACDIWTQNIRLSVITLPFALMTVANDSVTIQKHGFFAGWNWLLWVIVISAAASGILVAVVMKYADNIKKSYCQSVALGGTALLSIAIGDSHFSVPLLVGVALVIASVFLYTLNPPPKVKSATPEVPPRDDDDLMLLDDDEYDDDESGDDDETELKLDEKDNGAGHNGECGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVS1</accession>
    <name>A0A914GVS1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVS1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11796.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11796.t1"/>
        <property type="gene ID" value="Gr19_v10_g11796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037769673" evidence="1">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11796.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9490" checksum="FEBCB73C456E2FB1" modified="2023-02-22" version="1">MMHFCYVPLLLILFFTEHCFPASATSDTKNETTTVEAGCRRPKCRFWPWCNAAGHPNTASIYFTLLIAFVPIARAIYVGPVDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWH8</accession>
    <name>A0A914GWH8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM136A</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM136 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWH8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11822.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11822.t1"/>
        <property type="gene ID" value="Gr19_v10_g11822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008560">
        <property type="entry name" value="DUF842_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096:SF0">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05811">
        <property type="entry name" value="DUF842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11822.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17284" checksum="20D235CD0C63C40F" modified="2023-02-22" version="1">MPSDKDEFIRSQDRMKDSVNQVAEELDISYIRKLQREMHLCSATCYDTRGAKRKEIDDCEENCRAKYQAVVAKVDDEFSVWQDQLNRCITTCQDKQNQKFGTDFANMSEQQRNQFTDGVAKCAGACMDEHVKILPKLRDRVVAFLKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXA8</accession>
    <name>A0A914GXA8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXA8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12023.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12023.t1"/>
        <property type="gene ID" value="Gr19_v10_g12023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18287">
        <property type="entry name" value="BTB_POZ_BTBD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000051">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12023.t1"/>
        </source>
    </evidence>
    <sequence length="686" mass="77319" checksum="ED0D676EC58A9614" modified="2023-02-22" version="1">MSTHYYPALRNCGSCASLAGSLQEFNSSSSLNNRTSSFSPYGEIQNTAQLVEQIAFLYLNEEFSDLVLIVDGQRFPVHRVILATRSSYFKAMLYGGMRESSEKEVTLFDTPVQAFQAVLKYIYTGKLQLKSLELSLVLDMLALVHKYGFSELEAAIPEYLKSILKARNSWRSPAWISSTITPQTFCPDNLFFNYPPQHSSEYSAETLFVRPNWKYFLPSAIGLMHTPKSPLASLRADQILDAIKEQNTKRSSELNYRGFLFPGTNVATPLLGAKVTGGDFRSALLSNKTSEDETSAADPIDRTYAKHLINQTNSGITIELGRPFILNNIRLHLMDRDQRTYSYFIEVSVDQVDWVRVIDHSHYVCRSRQNLLFDERVVKFIRVIGTHCSVNNTFQLSRFEAMYVTDSCAIDNSTTLQIPRLNIATIANNAIVVEGVSRSRNALLNGDTKNYDWDDGYTCHQLGSGALVVQLPQPFLVETMRLLLWDCDDRWYSFYIEVSTDQCKWAKVAEVNECRSWQTVHFLRQPVVFIRIVGTHNSANEVFHCVHFECPAMETDSASEEERVARLRRIIAHTVDEDALSATVQTSSNGIVPVEKFEFLESCQNALGAIVESIAAGVGEEVGSQEEGEERQAEGRPNHSLFGDIDQQEGSSSGRAESESSHSETVYEENRDRESMPPMESHETSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXI0</accession>
    <name>A0A914GXI0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXI0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12072.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12072.t1"/>
        <property type="gene ID" value="Gr19_v10_g12072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12072.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33122" checksum="173C6F4A4C32AB35" modified="2023-02-22" version="1">MIRKHLEAKFNSPLDGFKDEIDDVIGSCISGMNVAKKREESSDKCGKQSSGTDSSESDFDIPSSTSNANSRKRKADGGGGKRPAETDQTVADDLASAVKRRRSANQSAPKKREPKAKDAGKNGNRKRNSAFSKICVISAELSSILGKNYMRRSDVVKEIQFVILDEPLKRVFGQKMRIKAFGMMSELKKHVKDVALLDDTARARAEADIAEILAREEDEEENQLDKEDSEKLTGHSGENDNSATSSSNSGDIVVKAEEPPPTTDILQQSVLNTEQQQLVKEEASEESSEDTDCESDSDSDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYF4</accession>
    <name>A0A914GYF4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12489.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12489.t1"/>
        <property type="gene ID" value="Gr19_v10_g12489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001298">
        <property type="entry name" value="STE20-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022165">
        <property type="entry name" value="PKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051585">
        <property type="entry name" value="STE20_Ser/Thr_Kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538:SF3">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12474">
        <property type="entry name" value="PKK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="914"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="522"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="922"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1180"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1205"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12489.t1"/>
        </source>
    </evidence>
    <sequence length="1215" mass="136881" checksum="EEA51583FD8792CF" modified="2023-02-22" version="1">MAIFGLFKQLLLGQHPSSNSQSGAARLPAVVQCDVNPMDSQWRTMGEIGEGAFGKIEKVCSVESPHLIAASKTISLQEGEELDDFLIEIEILTLCKGHGNIVDLIACYFHEQKLYMMLEYCAGGAVDNIMVELNKPLNEPQIAHVTREVCRAVDFLHARGIIHRDIKAGNVLLTADAAVKLADFGVSAIIKNNQRRDSFIGTPYWMAPEVIICETFKDQPYDCRADIWSLGITCIEMAQVEPPNHNMNPMRVVIKVQKSEPPTLAQPHRWTPEFSDFLRRCLVKNVDGRWSAAQLLSHPFICSADDRRPIVRLLCEKNAEVVDEEVMEAESGTTTDVDEDDSVKIVINNTDDHGHEHEHDDTFRPQEEAIQILDELDMALDEDGIAQRECCSATSGSQLSSTASGGSSSNKNNIGNGTIISCSGGDGTTANSVGAEHAASAREPSAAPMGIASTSAPSTNVTAKRNNIPFSTKQFEAPQPPTAIQFEQQSPIPHEEAIQIHIPDELYMTLEEDGIAQRECCSATSGSQPSSTATTSGSSRTSNNIGTNNNNRGNAISVSTTTVSFQQSTVSVLDTTFNDPHKRQNNNTISVNIDTPRRHTVTGVNTSPTAPIQITPRQNTVPENTDLHRQSIVSNDSVSSLPPLKQIAAEYAASAREPSAALMGIASTSAPSTNALNNSANSSHEHQLPEPLDLPPPEPPVDYDFDSTPRAIAAQQQQYQPPAGVQAGRQPYHQQQKQVKQQQKRPHPPSAVEDVQPAPAQLRKSPHRATVTKRTRTYVIDGVEVTSTSLHVLSAQQDFELRKRELRDLKRMQREEARQQQELNSRSEQVREHQERRFVFEKQSVQRTYEAEIELVSRTQKKKMEETERQQEEELRTLAKSVRVEQERDLRVFRDRLRQEQKIMKQEVEMLPKAQRKNVSRQRKEQLERHQCERESDYVEQQMRTSEAVLLRARDRHREKLCLQEKKCLEQKHQLERNMETALWELEEAQLAEKHALLTQQFRDVFHLQRTHMLARHAKEQQHVLRINQSQEEQLLRALNADRKALPKMLRSEAKTRTLMFRKSLEVDLPGESDTWTAKVRAFEEREKQRTRQKTEEYDLKCKRRLAQLVERNKEVLRELEEIHNEKRNMLLENERAKLGEYEREYQQLLADWKASLPARKSTLEAKFSDELATQERFYGTDGTAMSSSTSTSSSSAGGGPTAPFSFSGSSQKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZI2</accession>
    <name>A0A914GZI2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZI2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12243.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12243.t1"/>
        <property type="gene ID" value="Gr19_v10_g12243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.180:FF:000002">
        <property type="entry name" value="Proteasome activator complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.120">
        <property type="entry name" value="Proteasome activator pa28, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036996">
        <property type="entry name" value="PA28_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003185">
        <property type="entry name" value="Proteasome_activ_PA28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02251">
        <property type="entry name" value="PA28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="5">
        <location>
            <begin position="98"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12243.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25849" checksum="28793895CE31073F" modified="2023-02-22" version="1">MSTGKKASNKKFEEYKNELLKEAEAIVEEKFPSKVIEFNELLKSPKYQYDRLVEVTALTDVNDMYYFSVPAELINELRPLLREAIEDVNKLFLSFAKHIDQIGHFRVKAWIQLLRPKIEDGNSFGVSVQECLNETRNVKAGMAGFLDQMSKYFASRARFEAKIARHPHVEGFRRALLDTDKKAFINIRLGISEMRDHYARLHDLLMKNIDNIKKPRLLTRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZN8</accession>
    <name>A0A914GZN8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Barrier-to-autointegration factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Interacts with emr-1 and lem-2. Interacts with lem-4l, leading to decreased phosphorylation by VRK1 and promoting dephosphorylation by protein phosphatase 2A (PP2A).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BAF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZN8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12288.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12288.t1"/>
        <property type="gene ID" value="Gr19_v10_g12288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.40:FF:000005">
        <property type="entry name" value="Barrier-to-autointegration factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF6">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12288.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10305" checksum="F6A9B01C7C77018D" modified="2023-02-22" version="1">MISPPYFTHRDFVGEPMGDKEITAIAGIGPVYGKKLEDKGFDKAYVLFGQFLILKKDKELFTEWLKEEVGASSQHAHACFNCLEEWAGQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZR6</accession>
    <name>A0A914GZR6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="2">2.7.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914GZR6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1190.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1190.t1"/>
        <property type="gene ID" value="Gr19_v10_g1190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039758">
        <property type="entry name" value="NAGK-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862">
        <property type="entry name" value="BADF TYPE ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862:SF0">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="5">
        <location>
            <begin position="107"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1190.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35286" checksum="8F7B07FF28E8F707" modified="2023-02-22" version="1">MGATHSNLVLINSTGPSAKIAGQWDDGPALNCLLNGVERTADQIATWMRCCVRTDNTEQPILLPIASLGMGLSGAEDEGTNRRLLAYLKAQHGDLAHTFLLTSDSANGEIFGVGGWGHLIGDGGGGFWVTMRAIKRIFDAEDGLLLSVDLGIDNDSAQIVEVKKALLEHFALESKLGLLDILYNPNFNKSLVASFCKKLSEVADGGDAFAAELFSDAGKALAQHLVSISRHCDAEMLKELPVVVIGSVFKSWHFMKSGFERHMNEANAAMLTKLDRRIYRIVLYQLECSSAVGAAILGAKQTNCETTTICSFGVLQSKKVFEEFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZT6</accession>
    <name>A0A914GZT6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WD repeat-containing protein 48 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g12325.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12325.t1"/>
        <property type="gene ID" value="Gr19_v10_g12325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="11">
        <location>
            <begin position="2035"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="2265"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="2311"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="2354"/>
            <end position="2396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="2406"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="2448"/>
            <end position="2489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12325.t1"/>
        </source>
    </evidence>
    <sequence length="2879" mass="333558" checksum="26D7EB78DF5E05C3" modified="2023-02-22" version="1">MKVPTSVSFVGQAGASSAPSLDCPSVQHQLSQQEERIFTDKSKKWKQLQSKRFAEKRKFGFVDSQKEEMPPEHVRKIIRDHGDMTSRKYRHDKRVYLGALKYMPHAVIKLLENMPMPWEQIRDVNVLYHITGAITFVNEVPRVIEPVFIAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEPIQMELNEDEESLVKEWFYDHKPLSKTRFVSGEAYKNWSFSIPIMSTLYRLANQLLTDLLDENYFYLFDLKSFFTAKALNVAIPGGPKFEPLMKELNFQDEDWNEFNDINKVIIRSPIRTEYRIAFPFMYNNLINALPVTVSWHHAPSVVFIKTEDYDLPAFYFDPLINPIAQRNTERMPEPLPDDAEEFEISSDVVPMFYEFPLYTENTANGMALLWAPRPFNLRSGRTRRIIDVPLVKSWYKEHCPAGMPVKVRVSYQKLLKVFVLNALKHRPPKPQKKRYLFRSFKATKFFQNTTLDWVEAGLQVLRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDAHVQYRLNNVDAYQLSDGLQYIFAHVGQLTGMYRYKYKLMRQVRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPGWRVWLFFLRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARVILQHLSEAWRCWKANIPWKAKADWWTNSAHYNRERVRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYVSAEEAVAIYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKNRLNQSQREELALIEQAYDNPHEALSRIKRHMLTMRSFKEVGIEFMDLYSHLIPVYDIEPLEKVTDAYLDQYLWYEADKRRLFPSWVKPADTEPPPLLVYKWCQGINNLQSVWDTSEGECNVLLEAKVEKMYEKMDLTLLNRLLRLIVDHNIADYMTAKNNVTINYKDMNHTNSFGIIRGLQFASLIVQYYGLVLDLLVLGLRRASEITGPPQCPNEFLAFEDIATEGAHPIRLYCRYIDKVWIFFRFNAEETRDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTIEWENSFVSVYSKDNPNLLFDMCGFECRILPKCRMASDDATNRDGIWNLQNEVTKERTAQCFLKVDQESMEKFHNRNRQILMSSGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPARFPPVVFYTPKEIGGLGMLSMGHVLIPQSDLRWMRQTDSGGITHFRSGMTHDEDQIIPNLYRYIQPWEAEFVDSQRVWAEYALKRQEANAQNRRLTLEDLDDSWDRGIPRINTLFQKDRNTTLSDMIQALGGVEGILEHTLFRGTYFPTWEGLFWERASGFEESMKFKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDLELDALEIQTVQKETIHPRKSYKMNSSCADILLFAQYKWHISRPSLLADTKDVMDNTTTQKYWLDVQLRWGDYDSHDIERYSRAKFLDYTTDNMSIYPSPNGVLIAIDLAYNLYSAYGNWFPGMKVLLRQAMAKIIKLYSSEPTEPYLTSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPMNGAIFIFNPRTGQLFLKIIHTSVWAGQKRLSQLAKWKTAEEVAALIRSLPVEEQPRQIIVTRKAMLDPLEVHLLDFPNIVIKGSELMLPFQAIMRIEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRVILIMRGMHINPDKTKVILKPDRTTVTEPHHIWPTLTDEEWIKVELALKDMILNDYGKKNNVNVASLTQSEVRDIILGMEISAPSQQRQQIAEIEKQTKEQSQVTATTTKSVNKHGDEIISATTSNYETQTFSSRTEWRVRAISSTNLHLRTQHIYVNSDDVKDTGYTYILPKNILKKFIIISDLRTQIAGFIYGVSPSDNPHVKEIRCIVLPPQWGTHQLVHLPNQLPQHEFLKDLEPLGWMHTQPNETNGTVSGAGYEWGRNNTDKGNNPKGYLPSHYEKVQMLLSDRFLGYFMVPSAGGWNYNFMGVRHDVNMQYDVCLSAPKEFYHEDHRPLHFHNFNVFEDPLGVATADREDIFDSVQFVTILFYSFVMQPQAKRKIQISFLIRNGSVESKHRGFVNSLQFDPITRNLFSAGSDSVIRQWDTAATSDSAAFVRSLEHHCDWVNDIVLCSDGSRLISASSDTTVKVWHTRRNGACLSTLKTHKDCVRCLAYAREPAELVASAGLDKCIYLWDVNTLTKVTATNNTVTTSSLRGTKNSIYSLAMNECGTVIIAGSTENLLRVWDPRTCQKIAKLRGHNENIRAISVNRDGTLCLSGSSDGTIKLWSIGQQRCIGTIRCHSDSVWALQTDTAFSTVFSGGRDHRVFRTSMRNLNDSELLFIERKPVQKLLLVDADRPKQLWVATWDSSIRRWPIDGQSTGHAEGGGPRVKEAAMELHGAPSIRKFAVLNDKRQIVTRDSEGNVELWDVMQCGRDNVRKVWIPSWFSVDAKCGVLEITLDESDAFSAWVSARDAGFTDKANDAKVNYGGLLLRSLFELWPHAYAGDDEDSPLQGFYSLPLHTPILIRQCHDDIVRPLFRTTVHDTASQSDSAMLRDVLPAWVLEVVELNQFPKFNKIPFFLQPHSSFIPKFPVKKDRLSATEMLQLRKVMEHVWEKILYPAETAGDDGGGGAGTAHSLATQLLENIEERIELFCNDQKLDSEMDLRTVKHLIWKQGGDLLIFYRPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H053</accession>
    <name>A0A914H053_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H053"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12710.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12710.t2"/>
        <property type="gene ID" value="Gr19_v10_g12710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12710.t2"/>
        </source>
    </evidence>
    <sequence length="228" mass="26399" checksum="2C877A1EF5D3EFBD" modified="2023-02-22" version="1">MNELGNCWKKELEKGMNQLKEELSAKMEQYQNKQQQNIDAFTEAQNGNAGLIPQQNRWDSTACHDELKLTEPDRLIVQYTGENLTWRSIFAERPISKNNFGIFYYEVWILAKESATIHIGLGSKQMLGHTGWMVQRHLRIRKPWLFWVTRSTDVADALWWTSVHRESPNLGEGAIIGCGVDLATPNNLHKKWAAFENYRFACPFCRRIVSAFRCVILATKLKRLWAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H054</accession>
    <name>A0A914H054_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H054"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12400.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12400.t1"/>
        <property type="gene ID" value="Gr19_v10_g12400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="616"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12400.t1"/>
        </source>
    </evidence>
    <sequence length="1033" mass="118142" checksum="DA1B58956FC201D4" modified="2023-02-22" version="1">MSPVTLPVLFEHNFPDGAVKRAAEKAARSFQSTQPKVFAWQILRESINYEELKNIQISLRTCQKFELLWNKRSYFKWGSATDQGKTGPFPSEEQRKSAQLDTPGGKAEQSADYFVPSMLPYSGICERICLVHNLFSVLMVSIKFEMPGIEHSDHQESEKTEDEDEQAPTLLKRSESSSANFNQRKRKLKEFDSAMISKEAKEAQRLERERLNRIEKNKKELNAAVYAPIIAGSSSINLDDQGFDEPNQSDDDDDLMFVGEVIAKKKTDLVELGSSEDEVEEPSSIANASDYAAFRMNQFCQLRHSEQFRFRRRRRSADYDKTETDADGRLLVNAGKPDSDPEVFVTPHLTNILQPHQIGGVKFMYDNIIESLDAFHKSSGFGCILAHSMGLGKSIQAITFVEIFIRITGQKRVLIICPRRDGIAQQQQNQLNSQFFPPVPPPQYQQQQQYRHQFFTMDYANFDRCNQPTPRWYPSNSSNSNTGMMEQQHFFNNPFDQQTSSTFDFSTHQTQPKKETAEANEQPQQQKDNLQQICFDSVELPCVNDKGSQKNGGDRHKQTTTAKKKQQLIGKGEECDLLSDEFLFESGNSIDLEWAEPLLCNHATGIVEHSSKMFVAMAIISETIRRGEKLLLFSQSVVTLNLIEQFLKKHSGEPVGPDGEPVQFVRNETYCRLDGSTSGSDREKLINRFNQNANLWLFLISTRAGGLGVNLVSANRVIIFDVSWNPVHDAQAVCRIYRYGQRRRTYIYRLIMSNCMEKQVFNRQLSKHGLQKRVVDEQLIEANVTTKEVENLMDYDESLDVVSAANRLEREMGEATEELDDDLLKMLIRTFPHNFFELPFLHESMMVEQEQDLSAEEKLEAQLLYEREKRGFNFPPQSYSANAIQSLSGANLQFPMGYHQQQRFLPKFGNPFATAFQRPWHSTPLPKHIELVSALEQQRKQQQTLASPVIIREQLTLPRVISLIGEPTQHTLRAGDQITMFCSQKGVYFRTLDGIILDATKTQYGRIMMQRLREPPALVRRATGPAEVIQIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0K7</accession>
    <name>A0A914H0K7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reactive oxygen species modulator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein MGR2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0K7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12508.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12508.t1"/>
        <property type="gene ID" value="Gr19_v10_g12508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12508.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="8841" checksum="8455A89FD902710E" modified="2023-02-22" version="1">MPAVPPGYQVVQQGRKGPSCFDKLKLGFVMGCVIGGSTGVLLGSFTSLRMGLRGRELFRQIGKVAAQMGGSFGVFMTVAQGIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1J6</accession>
    <name>A0A914H1J6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Microprocessor complex subunit DGCR8</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1J6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13162.t3">
        <property type="protein sequence ID" value="Gr19_v10_g13162.t3"/>
        <property type="gene ID" value="Gr19_v10_g13162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070878">
        <property type="term" value="F:primary miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19868">
        <property type="entry name" value="DSRM_DGCR8_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000021">
        <property type="entry name" value="Microprocessor complex subunit DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040375">
        <property type="entry name" value="DGCR8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482">
        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="327"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="488"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13162.t3"/>
        </source>
    </evidence>
    <sequence length="726" mass="82462" checksum="F4CC0E9F0D72B0CF" modified="2023-02-22" version="1">MSSNDEKELDEKSLITNDDEDDLAKLEEMRKCLLDQLRQEEQEEDDNQQLDAKYTKEDRTGLDEHLTDCNEDREEEQPGHLEQSVQEDSSSTINTSDEELFEEDGSTSVGPDIKYDEIDTMLEQPMEQANENGDRPKHISKKFKRVLEFRGMDHFDVLPDGWVEITHASGLPVYLHRPTRCCTFSRPYFIGRGSVRNHTVPESAIPCLFQRKVRNEIEKPEERNNTLEGDDSLLSRLSAPSVKVKTEVDLQNAQLNSEQLYEYAKTRNFYKRKKERKTLNQSVQSNGTSREARPILPSTVKLITVPSLEADSKPHQRTFYLNPQGKTSVSILHEFVQKVLKCTVRYFFNETRSSATPFHCVAKLVNSGTPTAAEVGIDPASKRTTEENENAANDELIALGEGFGAGKKSAKLIAAKNALQKLVPGIDFDEEGIAIASRSCPKTNDGIHSNNENAEGTTAFENPLHIFDLLTITDTRIPELSARAGQPSPYLILQEYLKRCSTYGNTTIQLTTRRLRHQMHEFALSVGGNNNERVRVVSTNKREGKQKAAQAMLKKLHPNNSTWGSLLRLYGYEAQMKLKEVRKCKDSVTRLQGISDDKCQEGKTKGEFQPNTTSLPTKKTKCYCRTINKRRKDFQSELPILSEEQLRQLSGKLAAKQPTDDELLLLIKSIDEYSHFFLSNHILTRASRCALFWPSTNFDELNFGSECYRRITRGVDRLKHGQTCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H279</accession>
    <name>A0A914H279_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anosmin-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H279"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12556.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12556.t1"/>
        <property type="gene ID" value="Gr19_v10_g12556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042447">
        <property type="entry name" value="Anosmin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131">
        <property type="entry name" value="ANOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131:SF5">
        <property type="entry name" value="ANOSMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036719437" evidence="2">
        <location>
            <begin position="27"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12556.t1"/>
        </source>
    </evidence>
    <sequence length="816" mass="91534" checksum="CFF300119036BD60" modified="2023-02-22" version="1">MAFPSFVLFKMLFGVFVHLLSNVGTSSTVGGSEDLISARCQSKCLYELEQRHKSNAETRRLLRHQMSTLCKDDIFCASCILPCRESLYEYDLCSHTLCRDTPDPTHCRESCIFLEQIASKKSGHCPPQKPLVPVSECSAFCDVDSDCAEIDKCCVVGCSRSCLTPSLNDSRLLPRPEGITVNERKRKRSAILRWVMKRLSPQHTATNSNLFVIQWRWSVHKMPETMAPWQTIMVRNKMYAILKHLLSPGRFYVFRVAAVNMHGTHGFSQPSHPSFKLSTELKAPSAPLNVTFIYESWRPPKIVWNPPNSEVPLKEYRLSWWRTSDELAKAFELRQRRHSKQKNTADDDYEGLLGEEIDGDEFAPKRSIVLPSYSTKAELAGLEPGYFYIAELYASVESSEGDLRGDPAVLLIRMPNKTAGTKMLEPFNDDAETVQNKMNSSAPKLHVEVKTPYFEDGRLKTIISWLSHPKCRPNGGHRRENTAKFRVSIYSLRCFIELPPQQFYVQNCVATLENLQFSCEYSVGVEDADNKRIFESLTFSTLPCEQTPTNAPPLKCGGIVSSGTSSNGTPAAEAQRLEARRHLINDETATIKITTELSSNLRTETDEEWLPIGQLEAAENGNAESDKDVQNDGKLKTKQKTAAKDVTEHRLNCFATSVESAVCAWTWPADEQQEQRRHNSLIGFRTVLASTLPGSPSNVSILSAEQRRAQLTGLNPKAVYRFRLQAVTALGLGAELVEHFSTGGHLAAGNAKMLAANMDHNFEQPELLEKDVHVGHFAHTAELPWDSSARKASFCLVFVACWTISLLRLFVYVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4G1</accession>
    <name>A0A914H4G1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4G1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13754.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13754.t1"/>
        <property type="gene ID" value="Gr19_v10_g13754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="263"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13754.t1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49598" checksum="2940AB7EB9728ED6" modified="2023-02-22" version="1">MVRIFRSTKLKNKTVLEKTAQFAVVEPNSSSECSSADFKTETAQCSGKSIKKTSNDQTSPVTPEKAQSRVFGIALMSVKKNDGKQQEEVATDSVVQAAESSSSITEKAKIEKSQSPEQQNGTAKMKEAVDGGGQPTPVKTKRNKITWNPTEVAVKRRSSTRKAETKDLRDNDKAMADDKEAVDGVGQPTPVKTKRNKILWNPTEVTVTRRSSTQKPETQKASMLASISFSSFGMSHEVPRRTPLILTALDGCTQIAPFFTNAFGFSNHFACRFTVDGLEFCCTEQFYMYYKARIFGDEGSAVAILRSRDPKAIKQFGAQIRLFDTALWRKVSILVMLIANWKKFEQNPMLRQQLFETGDALLVEASPSDIYWGIGIHVDNTDRVRNIKSWQTKSKNVMGRLLTRIRDTFKEREQYQQEWEEVRARLPELHKNAGAVSRRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4U5</accession>
    <name>A0A914H4U5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13844.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13844.t2"/>
        <property type="gene ID" value="Gr19_v10_g13844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1842"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1842"/>
            <end position="1858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13844.t2"/>
        </source>
    </evidence>
    <sequence length="1924" mass="220999" checksum="FE6288D10E8DF20F" modified="2023-02-22" version="1">MFPPILTNRTLNSTNLSTIDKSQCSLSPKDATTSNIDTELMADLNAAEQMLSVQAAKKQNKFFFTCPDIQREQSPERSDYSDYVDDDWSSIEDGENPRASREAQEAEIEDKYRSALNFLEEGNAERAVSIFSTLLLHPIMTKYHIPDWSAYDWKRAIADTPQKIVPNMAKLFFNINLAMIGLVEDPLQFYVQALSIRPDFKDLWFNCGQFAISRRDWRSAEFCMTQCEDEFRALEALSLIRYLNNDYFKCTAVLQRVFESCPEHQTGHVIRQLISESSPFWTECHSKLFSRDISEFCVEKLQKDKILRNFETFQRECIRPDDKCSSLFFQRVTSSLPSWLNSGNCFAIFMIALFAEQRVFFEFESQNHYVQRKIINFASPFLSWMSKCRSWAVSKGAANFPEQIALTEDSDGRAEGEAGNRAQIVFQDACVDQEVTNCNKNTKMPQAEIIDNEPETQDELSLRRSMRLIDDLNYFGNSLQPRPDDALNRQFNALTLMGFEDNDLEEQQIALSNHRHTVHFKSDSISTKETTKYPNTLRSFLGWVAFEQDPFMVLTLEEAEAFREVYVRWSGLCLGICPNATADLAVHQLAAELGSHRALSILQAFYGRRFLKRQKTFSNLFADGEEEIVGKSHLADSFRGTTMQFAQKSLNADNDVFRWVFDRIHSEQQQLRRGESDRPTVIERNEEINANSDESQQSMDCPNSSTVRRQLEVRYKWLIANLLPEELCLPNSEAFHFIHAFSELNSALGLMEPHWTLWSHAEFDIGCLTARNLKEVLRKRVRKFQLQQIDYLIETKRYEELKNVLLHQYDWASDSDDAHIKQMFLVIQCIRETDNSLTEIGLWISKILNEICRDDISDVLAKRSLRRCIHLLDELFPAGLIDRNLATESFFAAVGYYLGKLVQPALYEKSAQCSDLWRWCSKIAKFREGQLNVSELKAFYACDSALLDRRHPTKTTMLLAKGHEVLGKMKKCSRKEGMFLRLLIDEFLNTIRDPSVRLVLALPEYSDIRENVVSEIVQCLRCCLSDKFAQSRVRSNRIADHGSKLQWPVDRDFATKVLELILPPKLPEICSDIRVPSDFADLLIKAFDHLLEVDETQLRCLDEMLQSPFRLELEEKFDSDGLCCGYEERLQMSEEGKVRLENLTKIGNAEGEANTFSEFSAKCVYLLAYFHYRTGSGSGEEWLRKCLAIGGRHLPPNILASAWYALGRSLTYSYAIKNDEELLDKVEAYVFPFRMALFLHWEFAESHLDVGTIIYQLRTRFARFKVQRDVSKELRCKTQQKVEGMLQKCKVHFRLALHFNDSPKDVAWLSNYFLAKIAEKLGDPPETVLDLYYRCALALEEEGIQYLTKINRIKQTYFEPLEIHYKVHAYAHRYLGILNSPSFPPRTSFQCAKDLSTIHVYLKLFQHHGVQRRSMEDAHWSDAGFYEQPNLPKTWDRLLQPKSFKNNDVLRENVLSDDVEGEVADLIGSLVCASDLYFDIVRMCQTAFNVILQRFPHYKAFYRVARAFFDEKNFARCADILFDRLFLTGRKQKCNNFLENIVEIKRSDFERNGSFPYHLCKIVKLAVVASFKYDNIGRLKDLVVALTSYKPSSTSREILGEPLVKELLGMASRGFKSLAEKQQKLYGHDMQQLGKLIEQIEGVIGKLKKDGRCQKERSALETTLIACIQRRDKMSQRSDGHGIDLLESAAEVINVQQLNRLSSLTCRSHHTRKQQQFTAKLPIGLRATTLNASLSAEQNVAKSSVFSNAAPTQRQTHPLTMNSLASSSNLLQEQPTLPNSTAIHQSQNTNQKRLKPLDAEGFKMLHKILPSLGLNRIGLGMADKLRILQALFERLGYEFPKEKAAETSRIHEGGHSGKDNSLPVMQLQTSECGPSKSKDPPPLPIRPPAQRMTGLPPNAKSKNKTTKNNLDSSVCFNDYLRTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H573</accession>
    <name>A0A914H573_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermine synthase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H573"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13344.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13344.t1"/>
        <property type="gene ID" value="Gr19_v10_g13344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13344.t1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55016" checksum="98D76551C581F5DB" modified="2023-02-22" version="1">MKIFKMLRSKGTLIINTFVIENGENASSVAEGRQFLLELFRHHFGGHCYYMALPYFNNKLLVCSLALSANAPMTEKLFRDRMKALPEWLQRELATAETRIEQEAWRRPTRAKCVLSQCSSLRQPGDTVLGLSYCACAEFVVFSPVVRLADGEDPALIVQEVICPRGADHCFKVEDYILREEAASDGTRRIWYQRRLMDDSEDNVVLSVADLQPDKPDAPFSAQNALNWTVLKTSLSLQYTKGIVAQMFVTGCVQLTSTERTRRTLMVGLGGASVPNFLVELDPNHQVVSVELEPAVEYIARKWFGLVQSPRQKVVVRDGVDFIQRWTESEGHFDCLIIDACKISVPPPGQKYPLICPFFEAFGIYKYEGMLNKIFKMLRPKGTLIVNVFAKDDVNASSVAEGRQFLLELFRHHFGGHCYYMALPYFNNKLLVCSLALSANAPMTEKLFRDRMKALPEWLQRELATAETRIEQEAWRRPTRVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5I5</accession>
    <name>A0A914H5I5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5I5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14189.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14189.t1"/>
        <property type="gene ID" value="Gr19_v10_g14189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14189.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11590" checksum="28211A7DEEF80F7D" modified="2023-02-22" version="1">MPQNLRIAYHLCLSKLSCITNEAVPRGKCSTLKPLAGHGVAGGHVLGSAGMPPWVLSTISAAVHELHAENCYTVRDWQNGSHGQESNLRLSVKLISDQLHIQANALTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5U3</accession>
    <name>A0A914H5U3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SUMO-activating enzyme subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5U3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13947.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13947.t1"/>
        <property type="gene ID" value="Gr19_v10_g13947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 11 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="15">
        <location>
            <begin position="49"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="16">
        <location>
            <begin position="459"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="155"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13947.t1"/>
        </source>
    </evidence>
    <sequence length="580" mass="64908" checksum="14F4610AD430F20E" modified="2023-02-22" version="1">MKSLAMSPVQIGISKANKNEFCCLVLYLLDCSNNIMDNEKEITYRDPTLTQRIANSKVFVIGAGGIGCELLKNLALTGFKNITVVDLDSIDISNLNRQFLFRKKHVGKSKAEVASGAVKKIVSDVNINYFHDSIMSERFGVDFFRQFSLVMSALDNKAARSHVNRLCLVAGVPLVESGSAGYLGQVGVILKGRTECYDCTPKANQKTYPSCTIRNTPTEIIHCVVWAKSLFNQLFGESDPDDDVSPEAEQKMEVLLRLKMTNYEPKQIFEKLFYDDINYLLSMADLWKERKKPTPIHFVDIIGEGLGGSRPNDDTNEYWSISKWAELFEDSLLALAESYREAVKEKRLLSWDKDDESAMQFVAACANLRAHIFLIGTRSLFDLKAMAGNIIPAIATTNACVAGMIVVEALKVVSAQLSKCRTIFINRQPNPRGKILVDQEPCPPYPKCYVCSDKGEVIVYVNLKEMLLRMFRQNVLISALNMLKPDVMDLCQNHRVLLSSEEGETDAILDRSLASLGVLNGTQLECDDYAQQLNFKLILFNDDSLTGDYFKMGDGHKKESETASEEMVPINKKAKILPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6G2</accession>
    <name>A0A914H6G2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6G2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14616.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14616.t1"/>
        <property type="gene ID" value="Gr19_v10_g14616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14616.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38244" checksum="A45173F32EB15BEF" modified="2023-02-22" version="1">MYGNASSYTDFVDLLNTGLTNAAFKQFTFVCLAITCTLTMRLLLLARFRPAVLYVPELSRALIVYLCFHCAGAILSLPYNAYVLIKFYYGTKSWHTPSTIYTIFWLGQWQNTYTAISPLVVLFLTVERCFVIKLATNPAKRERFGRWMCRASIVTMLAAFSASTCIYMAELPLDIDRLKLSSCASVSCLMLKWHNLLQLFFKCSVSFLNIFWCLYLLYSLRAFRAMKIIKNDLVIVTICFELCLNFLPALVSICFNYFGKGLLSNVASTCSALDACCCAIFYSLVLVPPRCLKRANASVGSTNEPRPSPSSPQHQQQLQQTPSFRMRPMQPSIVLPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6V6</accession>
    <name>A0A914H6V6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6V6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14736.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14736.t1"/>
        <property type="gene ID" value="Gr19_v10_g14736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037525156" evidence="1">
        <location>
            <begin position="25"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14736.t1"/>
        </source>
    </evidence>
    <sequence length="534" mass="61108" checksum="440B0B1E33A6AA5F" modified="2023-02-22" version="1">MHQILLLTIILMLFLLLITTVVSAVTVEVIEDGTPEGQDMAKALALSKRFFWRNMMANWSHYIDYEAFSNHEQIGEISREESRQLIFLKDLRQALATDAYVKCWECKQTNADDEAGSSSLTNQLKKDQFKCLCVKPKFLVEQGELQLSSAMEAIKSVYRDLFRWGSGFLSFEINFVNQKAWYLVHHWQLSYANWGSKLAENILLKVKEQLVGDEYLEHYKNAAFSDQFSKGPSSTARRSDTISLSKSILASMNELKYEETMPNGEKRDYLKELNAILKQAEMFSDLPKKIKKGKAEHVDLNAVVKVYQNYWELVQEFGLGMAAMCEGATKVEKIYDNTMHKFVEIFKAFGRVFQELSGTLLWRLRRMVHDMMLQMNHGNELKPLLPDPCEEAKFKVGLLDFECRALIRTLGGTIFNKSNGMHLDIVLLLLMLALCVACNGMPRSNDSTKIQKHNRAPEAMFQRVAPLTHQAQQVQRGQQRVNNGFNDVINGFNEVNNGFNDFISEVLVTNWGIRNQGKGCDEGWVTCKKRILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H806</accession>
    <name>A0A914H806_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H806"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14078.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14078.t2"/>
        <property type="gene ID" value="Gr19_v10_g14078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14078.t2"/>
        </source>
    </evidence>
    <sequence length="212" mass="24393" checksum="98953BC856A686E2" modified="2023-02-22" version="1">MFISFKTHFLQQQQQQQQQQQQQQQQQQQQQQQQYNAKVVCQTQHQQQQLKKFSSKIPTMLLLFTAVVFACSALQVAHAMPLQMLLMYTPDSSEGPDDMLLFPMQRSHLALIRKAAPSRELLANGLLSPNDDAVQTRHMEELMPSSNSNPYKLLMKRMPYASEAIDELKNDERPTAEQKNLLRAGRNIEENTAPKMYARHIGDLGGTMFRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H869</accession>
    <name>A0A914H869_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H869"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14926.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14926.t1"/>
        <property type="gene ID" value="Gr19_v10_g14926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14926.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27073" checksum="862F7BA1F36AAEB2" modified="2023-02-22" version="1">MSNGQSINGPPGPVSGQGTQGPTGLFVGIQGQQERVPADWSLAKKINGLSKEIKELAQESKRQFKEIQSLCLTKEIKDLAKESKCLVDKEFKELAKEIKGLVDKEFKELAKEIKGLVDKEFKELAKEIKGLLDKEFKDLAKEIKGPGPVQVNQGVRQGTSDSGQGNQDLSGLIGNAGQQIPTSEKGQPRICEAGIPGMPGVKGEPGFEGLPGVPGPPGICPKNCSPRDEELSQIRERLTKLEEAQLGKEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9G9</accession>
    <name>A0A914H9G9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9G9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15017.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15017.t1"/>
        <property type="gene ID" value="Gr19_v10_g15017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15017.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19379" checksum="B30C07C5A09DF5C8" modified="2023-02-22" version="1">MEETPLKTFDEIFEEGWWDKGEAEDLKMPVPTNFDKMSITKSTGRTPKLHKLNPIQLISLDKLNPIQLISLDKLNPIQLIRIFLSQKKFTQKKAELMRDGFKNSYGHEIDETVAKELGLTFKTIYVWKSELGHAKLNKPHSEQKDMMFVEENAAANVQEIENSNSESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA22</accession>
    <name>A0A914HA22_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HA22"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14654.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14654.t1"/>
        <property type="gene ID" value="Gr19_v10_g14654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502423" evidence="2">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14654.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24066" checksum="D6E6AF86950EAC10" modified="2023-02-22" version="1">MVAKCSAFIVQLLCSMAVHYCLVAGDQRACYETLRYQGGNKNVPAEMKIPLKKWRWSILEENNYIVLCVEDVGCQSLFCEDKYGEEVFRLNGCQTPGGHCSNEAFDKFCPTKTWCSKCEFNNCNNRIELTPSKTTTNTTTENPLVKNASAVTPSDLLNKLLFGNDSVNASTTENPVNEASTNGTGVLLLTKPYKTSSDGAVTLSNGLLLVLLFGALFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB53</accession>
    <name>A0A914HB53_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB53"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15444.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15444.t1"/>
        <property type="gene ID" value="Gr19_v10_g15444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="45"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15444.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31830" checksum="247278DCA10788D0" modified="2023-02-22" version="1">MENSGDASNKNDSQIKRRRRLQLELQCEVICALPFHYGRRMLLLCHPIATNCVALVRKQKKKFENRWDPMARHGSLRIIEPKRLVVQFTGENEGYRSVFAERPIPEKYFGIFYYKVKILGKENIFSIGLSTKQKTLDGWVGYYKGTYAYGSWGYFWGHAVAGCSRWNGNPYIGGKPQFGVGDVIGCGVNLATRQIIYTKNGQSLENLNQLSLKLELRRFDKNNWLLVRCPIERDEAKWAKWEREAAAELDCFWQWNCIGICLNDWDIGDFLPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBL1</accession>
    <name>A0A914HBL1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBL1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16010.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16010.t1"/>
        <property type="gene ID" value="Gr19_v10_g16010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16010.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23399" checksum="2C602554449EBD45" modified="2023-02-22" version="1">MNNFFNLFGAGKDKNNFFVAGKNANMNYYQLLGISEKAKPGEINKVYCERMRAYHPDKNPHGKAMTRLFTKAKETLMDPHKKAVYDQQMYIYATGVHHQQGQPMDFAVVDPVFPKFGDVLKMNKCEELALMMEQLTEKAAAAHGNNLNNMMDAFIKAVDLKFICNKCKKQLVLNDICYCKDAKTKCHCNSRVCCTVTLKERGKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCX3</accession>
    <name>A0A914HCX3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCX3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16200.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16200.t1"/>
        <property type="gene ID" value="Gr19_v10_g16200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16200.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8729" checksum="685AC46188855D8C" modified="2023-02-22" version="1">MKPRFVEWRLGEGENRFLEEFVGLEGMLGTGHCVNQSPDLQQRFEDGRVPVFAAGREFFRPFIAVGEEREAEVVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDG6</accession>
    <name>A0A914HDG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16494.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16494.t1"/>
        <property type="gene ID" value="Gr19_v10_g16494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16494.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38542" checksum="0667A3BAD6C555F1" modified="2023-02-22" version="1">MSDNVSDEEQQQQLQEIPVELGLLLALISDRFDALVDVHFKSRKWSLGRLHIHRARRGKGAQIVNIRSGGRLPIPQGPLPNKVTGFEKIEISYVDQTVIKFLQRIRRLFDSSGTNVAFYTFGDKTRRSWEIIWQKIWPLINDNIGRLFLDSSGLDRLRQFSPTILRGCAKLRLIDSMKLLPEFPAEDNAAASSRQAVAKWLLTAREDGLPKMFSDHFHHSGKTLLRGIKGSFVNASEPANFIMQIADNYYFAPFDLKNNLTEERLTFRRLDELTWLLVRCPIVREEAKWAAWEKEAIEWEEELEWNCINIEFEDSQIGDGMLDENDEGPSEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDK9</accession>
    <name>A0A914HDK9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAX-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PAX transactivation activation domain-interacting protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDK9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16375.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16375.t2"/>
        <property type="gene ID" value="Gr19_v10_g16375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18432">
        <property type="entry name" value="BRCT_PAXIP1_rpt6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="437"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="708"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="810"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16375.t2"/>
        </source>
    </evidence>
    <sequence length="920" mass="102561" checksum="2D169629AAD58E70" modified="2023-02-22" version="1">MCEPAAGSSNIAMKPGDVAAHQHFGAGNVCVGFGSGSPLEPLDPTKFRNIMVEKHEATGFGHFELAKGVKESVGSFRNTMTAEGELNVAQSESDQQQRASGTFVHPRFPPANATPAFHQINSQQLRESQQQSYFIQQNIQSHYGPMQSPSSASLYGVGGQQMGYLVHGDASSVQPSWNQPQQAQQKPQYVSSQLCQLSSRMLSPQQQQFGIAKPQPSQLTSYPAESGQHTISYPSPHPLHQSSPPIGNVPKQELQHQYQQQILPQQQQQTPRFAAAYSPHQLLSSRPSPAAFHMSSNCGVTNAAMDLRHYMNLTSGVSHTVAVPGSTTHNDQSVQQQSGAQPIKKAQSMFFNASSEMAHQQHIGGGNPTNVTFPSPPATFVRPSPSQDFGGVQHHNKHQQQMLRLPSSQQPSHAHFLQIPSQPQFFGHEPNLAATLNPDICLAGCVFLLVDDCDPHLVDFSLLPSIIRLYGGDIESNNPRGIPERVTHVVCSNWIENEALIQQALTPSFIDRMPRKLKRVVTLNWLNDAIAKRQVTAPSKACHLPSVWSSTRHNPKTFSKVIAAHGFSKRELLELKYMKSDFLVVTKSVFGEQLCQLAARTGSVLVNFQWLLELYFGCINCFTSASSCSPLALSKVCEMCHKLMVPWSQSTIPLHEEIIRLAHQSRENLMSDVTLFPEKHFKISNIAPTDKQIEEATVLYAKSGREVKFVLLFDGLFPEQIENLSRKARFLGAEITSLVALCTHFVTTSLHRTVNLLEAIALGKSVVTPLWVETSLRRLGFVQDLSFFVRDRENEKKYGFNLKATTLRTRNRRVFKGVTFHLSVGVQPKYEVIRRLIEAGGGIVQKEKPKGRDLLQYIQEDRTLFVICDRNSLSSYQFLIDWRFPIFNEDFVLMSILRHKIDISEEFHASPISHCQVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDU4</accession>
    <name>A0A914HDU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CLAVATA3/ESR-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mimics host plant CLE extracellular signal peptides that regulate cell fate. May play a role in the differentiation or division of feeding cells (syncytia) induced in plant roots during infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Host extracellular space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLV3/ESR signal peptide family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16102.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16102.t1"/>
        <property type="gene ID" value="Gr19_v10_g16102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043655">
        <property type="term" value="C:host extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044962">
        <property type="entry name" value="CLV3/ESR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36349">
        <property type="entry name" value="PROTEIN CLAVATA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36349:SF2">
        <property type="entry name" value="PROTEIN CLAVATA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037479019" evidence="14">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="116"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="144"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16102.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25342" checksum="863594A93CFB5AF0" modified="2023-02-22" version="1">MAKNAMLCLLILRVVLALAFATNKKGDEEPENHSTGIFGKVGRVVTVALAMSSRLGGADATRGGGAVYGGNLKSNLLPNNNWMAPPPPMAMRSAKVYDSKHSPAEYLKKFAQDFRRKTGMHSQRHHEETTLEQEKRVAGAGPDPIHHQDTTLEQEKRAVPAGPDPKHHEETTLEQEKRAVPAGPDPKHHEETTLEQEKRAVPAGPDPKHHEETTFEQEKRGAPAGPDPIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE49</accession>
    <name>A0A914HE49_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HE49"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15780.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15780.t1"/>
        <property type="gene ID" value="Gr19_v10_g15780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF136">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038009124" evidence="7">
        <location>
            <begin position="26"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15780.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27376" checksum="76061411AE4E15E7" modified="2023-02-22" version="1">MFRGLLKIGVFHFLILLLHASPADAEKFHFKEYPVDQSVFVGSNLTLRCSIMRYHGGSNPFHIQWRTNKGIILNQRNEIPGYSGRYSYSTNNPEELHLNIRNVSKEDEGQFQCQVLKLDKSFRVNAFVKVLGPSPSNVHLQRYQSGRIVDSAYSSNVPSSNSKIVKKAPCNSSSLQVTLFGSLALLLMLFIFFLAVMLRLNPSKKASQSRSSYVKSDENYAIELPTDRHHLQNYSNIPCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEM1</accession>
    <name>A0A914HEM1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEM1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16432.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16432.t1"/>
        <property type="gene ID" value="Gr19_v10_g16432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF235">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING RGS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="374"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="502"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16432.t1"/>
        </source>
    </evidence>
    <sequence length="674" mass="76586" checksum="0F46FA6F8338D3EB" modified="2023-02-22" version="1">MYWHRVPRRFVCIGTECHGKIPKFRITNSPNICNPIPVWPCWHLFLHLSARIFAQLFSIEPSSFCGAVFARRPPPSPRIDRAAPTKRGGKSSRSRAAMWRTYTGTFTPKRKSSAAVHSSRANGPAASSSAHPKQRPATLPRRSSSLDLDELIQQVEKQQQIGGRVSSTIVEHVTEQPVDEPPPPPQQHEKEEEEEEEEETSNNSTHSAQQPRHWANSVFVDPTAPSIGASVSSAQQWRASPPALFVAQKQSQQQVSSSINQLSVPSPSPTNSEREEGSAASVDEGQRQTPPQQQQSSSMSPVMDGANGAEATVDQNAKNDSKSANENADANKSSDDNANMFERCEARNRNRPAPTMPTTEGIEYPRAASWSASTVAEIMQDSIGRKVFSCFLHDALAEENLLFVEEVEKLKKEKQPERIRNGVQALLDKYAAYINLSSVAMSKLRECAKAETPDPKSLDIAHKEIYKLLENDQFPRFRRSQLYIGFLEQLLPRAYAERWTTSFDALLGNQVGRHHFRQFLFNVRAEENLRFWESVIEYRQLRNKSTAMQNMGRTIQQQFLREGAHNEVFLPFGLRQRVEKKIREKDADETLFDESVKHVELILKNDPYVRFLQSKEHKQIQYLTLISTNLRRRPKTLTFKQCKNVLKMKKGRPSSISSQAKKKREFVHFFRKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEW1</accession>
    <name>A0A914HEW1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrator complex subunit 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEW1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16354.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16354.t2"/>
        <property type="gene ID" value="Gr19_v10_g16354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057412">
        <property type="entry name" value="INTS4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25458">
        <property type="entry name" value="INTS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 4/Protein SIEL C-terminal Ig-like" evidence="3">
        <location>
            <begin position="470"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16354.t2"/>
        </source>
    </evidence>
    <sequence length="616" mass="69123" checksum="326869AB3CD916AB" modified="2023-02-22" version="1">MESKVDFKDLKLDNYSNSSNLNSVELESELIRLTCHFDRRVRTFAVRALEQICGEIGSMRVAAKACLSLEYYAHLAKLCKNSEQNVRVAALRILTRFAFVYPEEKVTTSKGFKIRLHDDAFSIVCDAMNDLEVKVRAQAANLLGTFENVSASFLDQTLDKKLMRNMTMLSDSNKNVKNVTTGAGYFGGWSTGKKMGEDVPMEKQEEESQSLIPTGSCGAFVTALEDEFMAVRQAAVYSLGKLAMGRPAFANACIDHLADMFNDEIQQIRLDAIRALTPVISHGILHRDQLDTILTVVDDATADNRMALHALLAKCNLTDSNCVLQCLKKLLHSLRRFPMDKFSIFSCLSDIGRRHPSLVQPLINDLLDIHPIFDTPEQSIDDDFYLARLILVLNAASHRSVICSLIPIYALKHYRYLRRSWPDIVPKISEFEQEKVYHNDSTAFALLPLLDGGPEKTEIGKKSDLRTARVLEPSKEFRNNETIRFVAGLPTGIFIRCLLVGVLDEELSRFRIQVEYPDQTFDFHRPRRGDFLRLDSRTVHLQTNVVVSAQRWATSASVIFTPGIVSETNNGNVSHKIVGKGGLKGPNQPHITPLASAENTARKCKISFTIHPMQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFS0</accession>
    <name>A0A914HFS0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16960.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16960.t1"/>
        <property type="gene ID" value="Gr19_v10_g16960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="91"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16960.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24447" checksum="968719C1BB84F87C" modified="2023-02-22" version="1">MEYILATDWMHNAYPEIDNNDSNKENIPPPKKPKENKKEEEEISWLRIIDEEQAKEMDNEPAKEMDNEKEEKLETVPIRCNCGGGNKRTQPLVEHLCQHFGCNIHELHVLVQNLEHRRAIVEYLRSGVQLRTAHLRPVTRNFGVRCNDLSILGALLAPAYRGYLGITVRMHYYIKHGIRLRHPNLPCVVEHGGSDHKTFFPLEVLSVVIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG31</accession>
    <name>A0A914HG31_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG31"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16632.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16632.t1"/>
        <property type="gene ID" value="Gr19_v10_g16632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16632.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41882" checksum="47BD359E9351AF6E" modified="2023-02-22" version="1">MSDNPTKVEKRLKEIFICDDVLFEVFQFCGPFVLGLKVALISDRLDFLVDAHFNSKEWSLGWLTIRRAADGKGAEIAKLKFRRLMPLSGGEDRVKVLVKHQLPIPQEPFPDKVIGFDCIWISYIDRSVIEFLKSIRRLFDPKQTKLSIGTRFDQNRTWEIICHQIWPLIKDNICEFPLYSTDTLDRLRQFSPTVLRDCAKLRVISCHGFLEFPADDSAGASSGQALAKWLLTAREGVRLKMLCCRRHSGEMEGLIEAFVNSTDPINFIVCLWAVTNAPFELKNTLTGERLVLRHVRSDLCLLIRCPIERDEDKWAVWEKEAAEWAVETTEPRLWWNSIHIELQDYNIGDELFDANEGPSEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGV2</accession>
    <name>A0A914HGV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGV2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17373.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17373.t1"/>
        <property type="gene ID" value="Gr19_v10_g17373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17373.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7848" checksum="5A314F8E2F605CEE" modified="2023-02-22" version="1">MVLPWRGERAMDLTTLHGTGDSGAVPEQSGGGDFAYGTANQPSIYVPFLCLQQVNETEAGGRKKLATKKHIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHF7</accession>
    <name>A0A914HHF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16983.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16983.t1"/>
        <property type="gene ID" value="Gr19_v10_g16983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16983.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29366" checksum="792077CC91FA7417" modified="2023-02-22" version="1">MRSSAAKLVQFVIQGLIRSGVGQMVLMNSDGQIVYYAPRDSEVKVPLDKFCQQLTAGLAAAKEGTMEAVYVAAWAHARLVAIHPYIDGNGRASRMLLNSILDHCGTRMRLSLPEDRRAEYNRLLAEGSRGNPIMFIAFVLQQELPHKIIDEIFGEGCWDNERDDEWNKLTLEQNALHQIDRQYTQLGQNEPNSTDQNPPPTESDHYGQIEPKSTDQNPPPTESDHYEQIEPKSTDQNPPLTESDHYGKIEPNSTDQNPPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHY1</accession>
    <name>A0A914HHY1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein zeste</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHY1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17323.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17323.t1"/>
        <property type="gene ID" value="Gr19_v10_g17323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17323.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33017" checksum="DCBDBE649CBCE39C" modified="2023-02-22" version="1">MCSHRLAIAKLVRDYKDPLFSPVSSQISRQNKQDLWEFIRQQAVAQGAVQYSRKSWKEIRDSVWAPIRRDTMAKVNKARTVGEDTVVYTEIDRVVLEIIGSMGTDPNGGEQDDSNANALGLTGQNKQQLDDGDNLNINALVAELAGDAVVAGGSDFKPNASTISQMIGGLDQFTAALKSGGGQMEQYQLQQQQISTNGGAKCSRGGENKGSKRRALDLDSISPLFVHPPPLCSSPFKGGNSLTESELDRETKQFRLEQIRLQNLLIQEQIEEKRLQNQMLRMELRKRQREEAASERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIN5</accession>
    <name>A0A914HIN5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIN5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17728.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17728.t1"/>
        <property type="gene ID" value="Gr19_v10_g17728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17728.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34010" checksum="F949BBA2AAE82A62" modified="2023-02-22" version="1">MDGIRKWLAKQAETNPERKKKHKHRSSSRYGARFGLSLRSISLEFYKDELRESDGGLNDVGGTAQQKKTRPNEVGGTSQQKKTGPNDVGGTLRQDVVKKRKSGPNAAKINKSEDESASMAFGNGRGRSRYVDKHCGDGKKTKSGPNAAKINKSEDESASMAFGNGRGRSRYVDKHCGDGKKTKSGPNAAKINKSEDESASMAFGNGRGRSRYVDKHCEDGKKTKTGPNASKINKSEDESASEDESVSEDESVSEDGSVSEAIGNNRERSSYVNPGHSSESEEYFSADSKYSSPGQPKSVGECTSSTLREYRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJB3</accession>
    <name>A0A914HJB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA-PLA1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HJB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1997.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1997.t1"/>
        <property type="gene ID" value="Gr19_v10_g1997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF48">
        <property type="entry name" value="INTRACELLULAR PHOSPHOLIPASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="3">
        <location>
            <begin position="418"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1997.t1"/>
        </source>
    </evidence>
    <sequence length="790" mass="86963" checksum="306353A13DC31687" modified="2023-02-22" version="1">MALQQNGEMPSSPNVRQKIVPTKKNVITIGKVKRRVTELKCAEVRWFYKNKEDAKWTPFKGFDSTVLEIAYRRKVGMPLDEAAKAHVETVAIPTSSVIVLDGNYRADDQMESVSAIYWGEDTLKIHRGSWFYADSFQPVRDNVIPETPVFSDSESSKKPVLTTLKWNEKEVRWNSVVDLFIAGRKGRVLRWVTRADGNVPLRRGFKDEADALEGMPNFSDLILVVHGIGQKGYQHLIAKNSAQIREAMLQLMDKNYPNEKRRPAVLPVEWRSALALDDGVTDVATLPKMEFARSTLNSTLMDLMYYQSPLYRTEIVNGVIRCLNSIYTTFKDNNPGFDGPVSIVGHSLGSVIAYDIMTRWSPFLLYDKIVSSAIEENMQNCEEVGQRKLLEDLHNSRKRILEVQGFMEQILISQEERIKFKVKNLFCLGSPLAIFIIMRGANYKSVIPQHDQLERIFNIFHPYDPVAYRLEPVFHENYRHVRPMKLLSSTNARQCYESAVYECHASYLKSQSKSKKKKKGAGKSGEDKLVEDNESKSGGKTHTQSEGDDDEQHHFRHGADSDSDDDAPSNGSRHHQQTTRRTSPTGAAPNTPTTAHGAGDCSATLAAPEEVDSACEAGEDGDGGAGQQHERTATAATPTNDVLRRTFTALEQNGGGGGGAVGGGGGGRVQAAVPATAELGKDEFGGEGRSPTGAAVAETAAAAATTAGAAAAAASLDDPKFGDAAHLVEEIPAERRLPLRLDFQIQPGAVPNGYWAMLRSHFSYWTNMDLAAFILNAIYPPPPPSSSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKD2</accession>
    <name>A0A914HKD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g213.t1">
        <property type="protein sequence ID" value="Gr19_v10_g213.t1"/>
        <property type="gene ID" value="Gr19_v10_g213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037387384" evidence="6">
        <location>
            <begin position="23"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="56"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g213.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34484" checksum="CFC4681E9F68F626" modified="2023-02-22" version="1">MFRKSSFLSPILLFLTILPTFSQSSNRDDAEAPCGVPPLNKNFTRFDYLMPDTHRLVGSLESSPHAWPWTGQLVAMRMEANGSATVTHKCGCALIARDFVVTAAHCFAKSRLPSRFIVLLGGHQIFDGKVQFKTFLIIHPLYQIVHSAYDAALLRISPVPKFDDFIWPICLPTRPAAVNGMCVVTGWGRLAEGGKRPTKLREIHVPVMRTTTCNSVQHYAGRLHYPSMICAGFNAGKSDACQGDSGGPLQCQNAKNVWELQGIVSWGIGCANPKFPGVYTKMFVICPWIRTEMRRLKTLYPLALKEQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKL4</accession>
    <name>A0A914HKL4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HKL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2.t1"/>
        <property type="gene ID" value="Gr19_v10_g2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12544" checksum="2CFD8434E05A3449" modified="2023-02-22" version="1">MAIQLVIFAWRLSPFFIAWLSLFFAIGPLEHLVAGDEHRRHVLLLLLPLAMLAGLGVYAVGSVLYGVFTFNDCATARKRLISEVNEAKQDLFRRGLIQKVDGSQMQRNKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKN2</accession>
    <name>A0A914HKN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HKN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2012.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2012.t1"/>
        <property type="gene ID" value="Gr19_v10_g2012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="8">
        <location>
            <begin position="73"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="7">
        <location>
            <begin position="224"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2012.t1"/>
        </source>
    </evidence>
    <sequence length="438" mass="48922" checksum="84C072C18E6168B9" modified="2023-02-22" version="1">MPKKTDKVAKRRHEREGTTSQQQEESDSDYEINEQVADGPLTFLINKIKTRKVKSVVDYDTNKKHVYPNFSTPKGHCIIFNNYESEPKPRTGTKLDEASLQRLFESFGYIVHIHKEKTAARMKYLLTSFAHRRFHEHADSCIVCVLTHGDEHVILGRDKQPINVNEFKDLLNGRNAPLLIGKKLFFVQACRGDREETGTGTSNVTAPTKTAADVSTQSRPGPSTTFNVTTNADFLIEFSTCPPFKSWRNTGTGSWWVQTLCTVFGRYGGEEDIYSMFTRVNRLVSEKVRAKKDAPAEEYRQTPEFTSSLTKRSVKKVPSLGTVPSLLLMGLFNTAVHHQNVVDPKTIAGCDHSSSASSSSLPNGNADAFGVDGLCLWCAWLAFESSSSVSIGPKTLKLQIHRILRFILGSLEPAAEAKRKSGTDLAVHFLSGWILWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKS3</accession>
    <name>A0A914HKS3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2041.t3">
        <property type="protein sequence ID" value="Gr19_v10_g2041.t3"/>
        <property type="gene ID" value="Gr19_v10_g2041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="9">
        <location>
            <begin position="794"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="9">
        <location>
            <begin position="1256"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="746"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2041.t3"/>
        </source>
    </evidence>
    <sequence length="1788" mass="200788" checksum="92EDF1B4F517ED1D" modified="2023-02-22" version="1">MRILSKTFDGETTTAQFPLPFDSALMNASAIENNPANRKVHGTITSSFPIKVRSCAKKLDNDLPMKGLPSSTSALKMFTGFTKRPLNNKLGGAVSALPSRQQLKQLAEDNEANTVRNGGDGISAGDNVPPSPCLSNISEQYTFASTPSAEFVPHQTTNHSSLQRMMTGDQRHLAGPLSSSLNTTQMMSSSNSSTSSASSCYSNLFTEICAQTAQCQPLPTIDINPENEALKQFNGLLKDANKLSPLSYNMIVSFLSGNKTNPLMDKLGTLITLPLSESVELEANDTSGTSAAAVFLVETFFQMNYCTGEWKRLRKSRLLKPEELGKYAHYLHGTKQLINNNHFGTASSNDCGGAMLNALSTPGGTDALVPNFAGQHVVQHQQGQQQHMVPRRQQQQQTFWALQQQQHQQPFGHMANKTKKKRSGVKDATKFKEKGIKFNTEKGQHILKNPGVVHAIVEKSAVKGTDTVLEPALLPFDNPSNFTFFFDTDRRRHCYLAPERFRDSEELEARASAVAGDFPNFYECLTEAMDIFAMGCLLVELLSDGRQIAFNLPQAIDYKNADEHTAKFFLKRLLSAVPDTEFRPLIAIMLDRDPKRRRDEFLKLSPCSSTVLFPQIFERYLYNYFKELQSIQSADALITKLFVERDNYMALLRDEDAANFVLFINIICAALRSCCSLTAKMDALSLLHQISKISTPVIIFERIVPYLAHSISDHFPLVRAEAILILCDILSTCANSIPPDECRLLIARWTQMMAEQKRRNKEARERRKAAAKLALKCLFDFSSIVLKLLKQSSSIDAVTEFFVTFCGCTDNEVRRCLFQPTNLDLLCQFFGASRVTDVLMHMITLLNDKHDWRVRAAFFEACPVLAQHLGQNRNSKLMPFLQQGLQDCEEFVVLECVCCVHALCRRQLLPKATICELLPDLVPLLVHPNKWLRIALVNILTILETDSCFTIADIYCKLTPLVTTFLRHPLIRLDCRDVLYETLVQPISRQIWDFICEQNNSAELITLIEERKTLEKLGGATKGNSGSNNSLLFNVISNVATMHHFDEKLNVADSKLPKTMGQLSKAQTLCSRPQNVLVSSSLWIQLTDFAPFKPALLPFDNPSDFTFFFDTDRRRHCYLAPERFRDSEELEARASAVAGDFPNFYECLTEAMDIFAMGCLLVELLSDGRQIAFNLPQAIDYKNADEHTAKFFLKRLLSAVPDTEFRPLIAIMYLYNYFKELQSIQSADALITKLFVERDNYMALLRDEDAANSVLFINIICAALRSCCSLTAKMDALSLLHQISKISTPVIIFERIVPYLAHSISDHFPLVRAEAILILCDILSTCANSIPPDECRLLIDFVFPKLCPIVISSACLPRIALATNLGKLAQISARFFEASVARMRSESPEQNQPEHGGGGCSTTTVQQMSSRLEKFLCEEKRLLLETERSSSIDAVTEFFVTFCGCTDNEVRRCLFQPTNLDLLCQFFGASRVTDVLMHMITLLNDKHDWRVRAAFFEACPVLAQHLGQNRNSKLMPFLQQGLQDCEEFVVLECVCCVHALCRRQLLPKATICELLPDLVPLLVHPNKGRNAIELSSVWQRRIKNSYGLITSFCIDTINQHWMLLTASSATTKNMLLWDLRFAGLEVCSWSHPSDRIIPLRSWALPNGSRCDRALTNCSREAELSIWDLSTRSRTDVLWPSTEAPLTYKTEMVSTAVAPSMIDGSHIIFTGDSEGSLRCWNLRYPNASAYLCGPYRRHLPSGDLNIGDLQQLKSPSRIVYRQMQITDSVLRVQAEDRSQLISPEAENGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKY9</accession>
    <name>A0A914HKY9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKY9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17586.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17586.t1"/>
        <property type="gene ID" value="Gr19_v10_g17586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000933">
        <property type="entry name" value="ABC transporter A family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="452"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17586.t1"/>
        </source>
    </evidence>
    <sequence length="1029" mass="115606" checksum="49EA7A9740F40725" modified="2023-02-22" version="1">MIIAINSVKRIKKATAHDEFSVPIKGGYEDLISGYLPSIYDTWTCEDRQQHITLAYSCSSSCDEKDANNSMNMLVKWYNSSRLDFVTHPFVDLETMKEALFSDLDSNYGGCPKFIGGVYFSKIHKRVPEWNKEGISEFWQDGGPDVSNYWESGFLSLQYAIEKAFIELVRGNVSLLNVEVQHVRMPIRAEDNLAKMSIAQLQFALALLSALFMLKDIALERDSWIMTYMSFMGLNQLAFYTSHFLIAAVKMLPFAVTFSAVCANKHLEYTSPSLYICMLILFCVTTLVLALFLGILFKKFTQIGPFLVLAIMAMFPLWYPPDINALPLCILESLNPIYAIDIAVTFFLRSENRQLKTGWLSMFAKDQFLVGIVFLMLLFDAFFFSLLAFYVAMVMPAKGASKHHPLFFLRFFGFKTFSMRKSALDNEIDEADSEIPNNDVEPYSVMRDESDIVVNKMCKKWPSGQFAVDNLSLEALRGQITVLLGRNGAGKSTTFSVLTGMLNYDSGQVLICGDDLKTELRQCQDNMGFCPQYNPLFEHLTIREHFQFYAGIKSGRLNGLHGKNALGQEIQRVAEEMGIEALLDMQARKLSGGQKRKLCVAIALIANSRVVLLDEPSAGMDPEARRELGQMLEKIKHDRTILLTTQYMEEADTLGDRIVIIVNGRLECNGSPRFLKNRFGMGYVLTVVLNIGSGTSMESMEAVQKNFDAALITIFTVIRKQLPSAYIGNTQNLPEFSVILPSQDKKHYANTFEELEQMKGDQKPIKSFGLSLNTIEEVFLRVNEPADTAADGTDSVDEPMKPADDLFGLRQQQSFLDFRLWVKQITAILCRQLRWALRNPFDSFGSFILLLLAFVIPTTLLVNVKQRNYVERSLSPAAANQYFSFQLQFAESAQYKNNFNELAKKIPCGTDDQNYPLVIGASEHNNHSKIQLVAHFSGVALHSAPMALSFVTNALLGKDFVISPKIAIYDIANKNHEENSLLRVSAAIAGVVVGTIFSCLPGFLLKSLVDDRSTCFKHQASADWILSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKZ6</accession>
    <name>A0A914HKZ6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable pectate lyase F</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914HKZ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2457.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2457.t1"/>
        <property type="gene ID" value="Gr19_v10_g2457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218357" description="Probable pectate lyase F" evidence="13">
        <location>
            <begin position="19"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="498"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2457.t1"/>
        </source>
    </evidence>
    <sequence length="599" mass="64405" checksum="B79427D8B5F72940" modified="2023-02-22" version="1">MLFFILLTIFIQIFQLHALCDFPPSSQTITVHSPIFVTKDKDFDNTTFVGSSDLLNGDCDVNNGKMQYLMVLEDGVTIKNAIFDKPGMGIYCRGSCTLKNIYFKKLCYHGAGFGYHSTDIFYIYQVLEGGGRGSPDKYFTQSGRGTTIIKNFCAEGPYGKLWCSCGNCEDQMPRNVQMYNIKILGPGLTIASLNENYGDTASITGLALYGQNSPSTATEYVCQTYKGLKQMKSMRPITEFLPTEHGSGPCSYSISPINNHTPVIPYDPPAPVLPYDPPAPVLPYDPPSPILPYDPPAPVIPYDPPAPDVPDNNQPMPYYYNQPGGDLPYVITGGSERVGKIARALTGLILVSSTMLNGVGATAAAGNTNVVDHQQALAAKPSWEWKPPALGHLNASHVLQNMDSSEGSGKATGKGNANNGRRGNSRSVKKAKKPAVVHKISAKTVDAAPISRQNVFDAKARIVPPETDCIYISLLLLCAKSKLFAGMDEAFAGDGRSCGLLLFGGGGGRKRASAGHKAILEKASDVFEAMFRFDEENAKAVVAETAPPAEAIKPVVITDVKVDAFKAMLAFIYADDLSGLNGDNAICVLQAARRIVGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMF5</accession>
    <name>A0A914HMF5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HMF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2500.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2500.t2"/>
        <property type="gene ID" value="Gr19_v10_g2500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035612">
        <property type="term" value="F:AP-2 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000369">
        <property type="term" value="P:regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="823"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="847"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2500.t2"/>
        </source>
    </evidence>
    <sequence length="967" mass="105217" checksum="8257E5C787D0AF85" modified="2023-02-22" version="1">MIRSAFSYLSQASNQLFQAGSTDAKSHPLVGQTLTIGDRLYAVRSLLAEGGYALVFAVEEKNGPGQSNTGGSGGAGHWYALKRQLAADRQAADAIVREIKFLKLLSGHPSIVRFCHAAQLGGGGSAEQKRRPPSPSQHHFAEFLVLTELCAGGPLIDVMRRGPFSVEQVCKIFHSTAQAVLHMHDRNPPITHRDIKLEEEMAKYTTPMYRAPEILDTYQNYPIGPAQDIWALGCVLFYLCYRAHPFEDSAKLRILNAKYTLPLADSVYQVFHDLIRRTLQPDPYSRPSIQDLCEQVEDVAMALNVQLEEPVLSADQMLVLLSEQPSMTIPGQRVAAATHSAPPSGSAAPATAATSTSSTTTGNNNASFLMDQGLSLLKTLKEKSSAATMLSDQFKAQLGLHQSPAQSRAESSRAKNGGGGAAKIAPPRPPAPPLFTTRPVQLTFDEENGAAADNDHRLNLNADTKQYKQQQQQRATQTPVDDFFSSLAWEADSGSRSSKDQSHRLHHQRHEQEQNLLSSEPDICFGPTLLDNACDEQQQRVVVDVPAPSAADQLLLLLHDEQQQLSTTIPAGRQRATASVQLTEILTNPGEPLKAETIGAASSLLSDAATTTSSSSTTTTTAATDNASDPKKSQKAGGNFDDILSSVYGFTSSTKLSTRSLADMSKESDNRDMDPLSIQIRDWTSGKERNIRALLGSLNAVLWPEAAQALKQPTVAELYVAENIRKHYLRACLVVHPDKQHPGNLWPKRIPPRWKCSRHKQKCPRLRRICRHETLAGQADARSAQEEMPPASVETHPDLSPPSVGVPSLLLPFANNAATSSSTTTALSASLPRSMSEVFPRRHRRTASANDGQQPANQSPSEDGTASCLGSPCSSSSLPAHFASPATAILLKSDQISAIARFAFTDLVITVLRLDFYRPSDQEAIFCKFALDILLKWGELPAKTQQSLRKRIEVPTARNKQHPGSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMG9</accession>
    <name>A0A914HMG9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMG9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1935.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1935.t1"/>
        <property type="gene ID" value="Gr19_v10_g1935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1935.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33682" checksum="A1A1584E1DFF0A1A" modified="2023-02-22" version="1">MHSHKFNQNLFGYLTFVVLLVFICQTTARKQSQKDLTKTGQEMLASAQTLLHGKKTPKTEGQKDPIKTGQELLDSAPTLFDGMKSGSFDDGKSMEEAAKNVESAALKVMQNLDKPKILQNIHQKIAENTFLDEEIKVKMTTLLGQFKIGIDKFNAIKIVYNQHENGLLRQRRRRKRADPTHGHDHDDKEDEDDDDEDDDADEVEEMEEGKPKTGRKANIAVIIKSVQVRKAGPVVATIKSEKVRKFGPVVICMIVLVIMLVAFAGLTVIQSGQPLQPLFTGVSIVVFLLLLCLGAGYYSLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMI1</accession>
    <name>A0A914HMI1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMI1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2862.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2862.t1"/>
        <property type="gene ID" value="Gr19_v10_g2862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2862.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15771" checksum="1C0B405B0B06E0EE" modified="2023-02-22" version="1">MLFLSSNTRRISSSPQALLHLLISSSLTFPSRFFHPKKAPPTPPLGDSVLHDQFCYDGPIMCHQPMEDNPSGALPVDNWAFVSGVNGQLNGFGGGSFCTDFEPNCASFRRFCFLQSIAEACLWSCGICGGFGGIAGGFGQFGKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMM8</accession>
    <name>A0A914HMM8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMM8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1993.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1993.t1"/>
        <property type="gene ID" value="Gr19_v10_g1993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1993.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21165" checksum="13CB66C15284811D" modified="2023-02-22" version="1">MARSIDKWMCCCGCLVTEGAYKMAWIFTVLNILGGLIGALLFISNGLNAKIIFYAVNVLVSLLCWLPILCGHIFGKRSHRMYLPFLFLFAISMVYAFFEVLYFVLQRILMFKSPDSIYVMFGLSLKEYENIIVGYTTAEFTLFVLLMIAFLAFWCWVYSIVFRAYKFTKQIGDDGTSNETKMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ07</accession>
    <name>A0A914HQ07_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQ07"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g317.t2">
        <property type="protein sequence ID" value="Gr19_v10_g317.t2"/>
        <property type="gene ID" value="Gr19_v10_g317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19724">
        <property type="entry name" value="bHLH_TS_ASCL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000020">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF5">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="1152"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="879"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="891"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1025"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1082"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g317.t2"/>
        </source>
    </evidence>
    <sequence length="1242" mass="137064" checksum="0CA79475F6A1EC1A" modified="2023-02-22" version="1">MKLRLIRRRKRMKHRRRLGLTGLNSAPGIARGEKQRRRWADPLVTMATENGQPATLEGTAEQSNGGKESLCRQALLPPDPEAEETLENKEETLALLFKRHLRNLVHFFVEDWFISGMLGFITAALSISVDVGYEYLNHYRAVLPFPSPFALLGFVSWVGFMVVFVGAAALVCKYVSVQAIGSGIPEVKVIMNGFMLQNYLSFRTLVAKVLSLTLTLGSGLPVGKEGPFVHMGAIVGTLLCKVTRAWQSSAFFSNEGREIEILSSGCSVGIACTFSSPAGAVLYGIECTHKYFAVKNYWRAFFATTCAALIFRFANAVIIPPHIAGTITAYYQTSFPNEVFLVEEIPVFVLVGLLSGLFGALFVVFHRRIAYFKKRNRTFRAIFGKNSLAFTIFMALIVGIVTFPDGLGRFIAGKYTFRETLGDFIANCSMSLYNVTSMGCGGQVIQRWTIEDLWAEEGPRRKSVLDSIDESTDTTAFMPNPFPVLFGYLIVNFFLVAICITLALPAGIFVPSFVIGACGGRIIGELMVVVFPEGIRGLDGPQIYPGLYAVVGAAAYTGAVTHSLSIAVIVCETTGQLSALLPVLIALMVANAVSSFLQPSIYESIINIRKLPHLAELPPSRISVHTLKVEQIMVRDVVFVTKQTTYKELRELLICTPHLRSYPLVTDEEERILLGSVARKYLHYLLTSHLGPDPALLLHGSRRRKSRNPSGFSNEAAAPAQHKMSMINDRNVFGNTLLSISPLHDDQGTKRGRLMPLLMRHQKEAISLSQTRSLLRRSTSVRDRTAQLRKPIDLDEVAIDAAPFQLVIGTSLYRVHTLFALLGLNHAYVTNRGRLVGVVALRELRAALAHIYTRGALPAAQSMSRLRLNSLNFGLCSTGRSRENSGEENSDNANTNSLRTDMSPNSLSGPLTQSTTVTSETSDGTLQIVCPTSFSSSLSQQLTPFLSPVMALAPPEEDSDEEETEEEEEWDEAKLLLEGAEDQLVANREANRAVSRAESNVPPGHAAENVSVLLDPRQRRRAPEKSNQIRSQNVPSSLGLSFSSSAADGTANAVPQSQHQSVIVHTQQTMATAPEAEENGGKKPKKRGRKRKRKAEDEEEADQQSDEDEEGAHGLHTDASPGAIGVRRFINPFEPRAIIPLPHELEMSTHGTTVWRRNERERQRVQQLNFGYTHLRERLPLIDRDRRMSKVDSLRLAIAYIRHLELLLHHGHAHWAECHCFKQSYGGGDGRSSGAESTPPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQB4</accession>
    <name>A0A914HQB4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQB4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2718.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2718.t1"/>
        <property type="gene ID" value="Gr19_v10_g2718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2718.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30210" checksum="2EA15417FEB07D03" modified="2023-02-22" version="1">MVYVQNSTATFTLFPNDCGQFSRDQFLAIARHGCCTEYAPWRFHTIVLRVRLAAQLTPAGGWGVATGTATALLFRSGRVVLTGVRGQHHQGLRQALCSAARRVCRRVRAALRAGRFCQNAPLLGVYRLTIRNLVSTLRVSHRVAVERLYSAMCRWRSRRSTQLHTDNIEGNPDDATGERVNGVGFEGSRFVGVSRCCLDLSTFPALRCTLLLLMPAEQREELQQQQQHPHTVSVTCLVFISGRVIVTGVRHLSIMEQAFENLDALLAAYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQI0</accession>
    <name>A0A914HQI0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQI0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3314.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3314.t1"/>
        <property type="gene ID" value="Gr19_v10_g3314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3314.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8751" checksum="BD2FB8571AC179EA" modified="2023-02-22" version="1">MERRRLARRRMERRRRARRRRLAAADGTAAAGEAAAAVGEDAEEDGDGDAKGAERTDGRTDGTERSTGTAPGGSTDRKTAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR13</accession>
    <name>A0A914HR13_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2910.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2910.t1"/>
        <property type="gene ID" value="Gr19_v10_g2910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2910.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11259" checksum="5F18430EDBAB74E5" modified="2023-02-22" version="1">MLRDNVRQSTMEETSRLQATTYAQLILFVQDNAHSALEYWGRVAGIFGNRRNQTSDANAIFIVFGIKKCANILADAPLDAQTFTETSKRRGRAFVNADIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRV8</accession>
    <name>A0A914HRV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3878.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3878.t1"/>
        <property type="gene ID" value="Gr19_v10_g3878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3878.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15588" checksum="26B90EAF8D0D9F57" modified="2023-02-22" version="1">MFWETVPKEGKIQLALIKEFRSLAEVTRYGAEEEKRNVQADGKFKPCGVRETIKFLREVFGMITPDKAFTLPKPVAKNVPSHSVEAQNYQFRFSNRVSTFVDEDATAEGRGRTRSQLPDRQIATEDSGFLEAGDWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSL7</accession>
    <name>A0A914HSL7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSL7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3579.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3579.t1"/>
        <property type="gene ID" value="Gr19_v10_g3579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037180138" evidence="1">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3579.t1"/>
        </source>
    </evidence>
    <sequence length="479" mass="54783" checksum="5460FD44E463AF10" modified="2023-02-22" version="1">MIGVFQLLILLCSLSKIHAINDKQFLMPFPLELSLSQKCKEKGQLQCQDSCGWASCVVASDAYSNHANNDCCPPGYAFKCCAMLPQMKYSFVHKNMAVMFREMEKKCKDKSGFCVCQPRWANMMNGLCCYANGGCHCCFNPNEPIIGKLPKNVYKPAHLRAKKGCGEGYSNCIWMEGAPKTHCCPHNYQLAHAEKRFVSTVDDHRDDGVIGSYGYDVRFASQHVPQYAWLTKGSIYDRLGKYGRLLSAISGDPLAECGYTIKYDGMDWEEMGTGQSLFEKRKIHHIPDQYECASESYWVPHLLPDLTTITPEERKYTWMQKNTAEMIREMDSKQECKKSTVFCACNALHFDQMMNGMCCDSSTDCDCCRTDPTISKRPMLSRDPASSPSCKEQIKNEIWNRDVAMCHWAEKWPASSCCAENYKLVAKDERYGWQEVPESSPPKSIKGISRRHPLCRDGVPWIYPMICARDWYWVPRTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUY8</accession>
    <name>A0A914HUY8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Galaxin-like repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g423.t1">
        <property type="protein sequence ID" value="Gr19_v10_g423.t1"/>
        <property type="gene ID" value="Gr19_v10_g423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056601">
        <property type="entry name" value="Galaxin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24748">
        <property type="entry name" value="Galaxin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galaxin-like repeats" evidence="1">
        <location>
            <begin position="73"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g423.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29233" checksum="58E90174012216F6" modified="2023-02-22" version="1">MRTHSIDASSSLQQYSRHFTAVTSPSDNIGPNFPTTAGYRNSFSNFAMPLVLRACCGDNCEEFQRPEEMYGITCCGDEPSNQFEEICCDNVPRRRRQPSSFIDRCCGNQTLAYDQTCCQGVVHNIPSGECCGRMAYPRNSFNTLCCEETLITNVDPTLTCCGKNAYDGGKREMCCGSSVYLKELFDGCCSLYGRNPPEYKQFSSRSHQCCDKPIEKFGPTKCCYLKDSQGRFFPKSYDSSSQCCAFPYTKITTKNANGTCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV05</accession>
    <name>A0A914HV05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GOLGA6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HV05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4726.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4726.t1"/>
        <property type="gene ID" value="Gr19_v10_g4726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026737">
        <property type="entry name" value="GOLGA6L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23143:SF31">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23143">
        <property type="entry name" value="TRICHOHYALIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="303"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4726.t1"/>
        </source>
    </evidence>
    <sequence length="497" mass="59205" checksum="B4E23BDB80F8ACBC" modified="2023-02-22" version="1">MSISPESTGEDITADQEHLWPIFEELLRLQDRIRIALLERQQTINSLTSSASSDLVTPNGNVSVEHFSLLRAKIDELERKQKSDHEEHRAKIDEATKVKVAAEWKHQQLLIEHKALQTKMEEYHRQQQQKMKEEQQKMKEEQQQKMKEEQQKMKEEQQQKMKEEQQKMKEEQQQKVKEEQQKMKEEQQKMKEEQQQKMKEEQQKMKEEQQQKMKEEQQKMKEEQQKMKEEQQQKMKEEQQKMKEEQQKMKEEQQQKMKEEQQKMKEEQQQKMKEEQQKMKEEQQKMKEEQQQKMKEEQQKMKEQQQQTIDELTEKQKGLTLQNRWDSAACHQGLALSEPNRLIAQYNGKHRVSCSVLAERPIQKGNFGIFYYEVKILRIKSFIPIGLATKEMPLNKTVGDFKGSYAYSGRRGHFFGHEVKVSSNIVGCSYIEGIPSFGVGDVIGCGVDLATRQIIYTKNGQRLETTGLFVDSAAELFPCVSLLRQWRQNRSKLWLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV16</accession>
    <name>A0A914HV16_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HV16"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g443.t1">
        <property type="protein sequence ID" value="Gr19_v10_g443.t1"/>
        <property type="gene ID" value="Gr19_v10_g443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF256">
        <property type="entry name" value="GST C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g443.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24422" checksum="272B7122A879400B" modified="2023-02-22" version="1">MAKFKVKYLNLRGRAESIRLLLNYVQQPYEDSRENFLEFANYRDKLPLAHLPKLVVDNKFELCYSSVILQYLGEKFGLENETAEEKAICAMLAQRINDHFEYLKPYVNCLLGLIPANNLPSLAERCLRPCITEDFGPVFERHLEANNTGYLVGDKLTWVDFFAASFADLALTFGRFDILDRFPRVLHHCRAVYSLPQLQQHIKNRPDTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVQ5</accession>
    <name>A0A914HVQ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apoptosis-antagonizing transcription factor C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g493.t1">
        <property type="protein sequence ID" value="Gr19_v10_g493.t1"/>
        <property type="gene ID" value="Gr19_v10_g493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="2">
        <location>
            <begin position="172"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g493.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26986" checksum="AEB0DFF6E75B1FE6" modified="2023-02-22" version="1">MTDRLALWDRLMVLASKAHKAVDASSKISYGEKLDESLESSAELQKQVDRANNAKSTLLQLLLADCLTTDSKIREFSDETSISDRFKTLKEGNESKMAVDLLNGLPLGQLFAKLQESEGDDEETRTRVEEARRAGFLVLLSLVKAGVTPSDEPLGNFGQQKLDEEAMMNGLNTLKWLKRQRSLKQRGKKRKQEVDTKASKGRKIRYVEIPKLVNFFPATPETIPWTHGKRDELFKSLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWW9</accession>
    <name>A0A914HWW9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWW9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4771.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4771.t1"/>
        <property type="gene ID" value="Gr19_v10_g4771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4771.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11422" checksum="AC74EB1DF485ECC3" modified="2023-02-22" version="1">MTFKVKKFQGFLKSVVMAQGYGRHSEAEVEEIAKKNLIALSTYWTILMRSPQVHRAHSHIILIFAIIFVEGMIGGECYTFFGKIHRKASPEVKEFSMSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXL1</accession>
    <name>A0A914HXL1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General transcription factor 3C polypeptide 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXL1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5412.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5412.t1"/>
        <property type="gene ID" value="Gr19_v10_g5412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="213"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5412.t1"/>
        </source>
    </evidence>
    <sequence length="521" mass="58760" checksum="FA96446E7F9FCB38" modified="2023-02-22" version="1">MSSHSSEFPSSSAANQRVAEFVLIEYPGVVKNVQAALDTLGGVRAVSNTHFNNGQLELHFQPQNPFDSALSAERRNQSAVFSGQANLVLRIRRRKRRQTGEAMEDIKLGQILPGEANDGQMEIRCIGMVSTIYSFRNICDFQYLPLSNATTASAEGPVHFDLLSRIIPTDFTSALSWWNEQQQQLLQQKCRTTTEEDATTSGEDALASEVANFLPPYQFSRYNTPSKFILRDDVERWSFSGLRNERKALTITVNANDPFPEAPSEKALSDVELRCKNAELHQMLTELFTERPLWSRIGISYNTRLTEATLKIVLAKYAFYIGSGPWGRLWCRFGYDPRKDPWARCYQSIMVSFKHNQYIPERQRLKASSTASTGLLQPSQFFDYMYRPKVFPSLRQMWYCVCDVQLPIAQRICRKDFLETLKECDSTNGWLPAGRVDAIRTAIKKDVAKSSARIGEEEFEDIGSGISAGGGETASVVVRDEDAEDMMLLDELAMEEEELDEDESAETGEEDLPLLMAFGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY69</accession>
    <name>A0A914HY69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4882.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4882.t1"/>
        <property type="gene ID" value="Gr19_v10_g4882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="51"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4882.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31067" checksum="BDA846AE19503309" modified="2023-02-22" version="1">MPYWASEKKKIPKEFVDGIEQLRLFDSSTKQVALWLEKTASVGSSDDVNNKRKGKKDTTNEGVLEAMGTVCKKFGTRFFGTDYGMNLVEFGEACKRIGKNGADMQYQVKEKVLIPLKMWKTDKYPIIIKNLKKCKELEETLHRTERALAANPNNSLYKTSENNARNAYDLVYTSCLDEVKEAKELWTQHIEYLREFMDIQSRNASFAHNQLKMIAGKLGTDVKTAAPPGPVKAAAPPGPVKAAAPPGPVKTAATTTTKMSTSSDYGILAPNPKSAVSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYR3</accession>
    <name>A0A914HYR3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Talin</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g5266.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5266.t1"/>
        <property type="gene ID" value="Gr19_v10_g5266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10569">
        <property type="entry name" value="FERM_C_Talin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17089">
        <property type="entry name" value="FERM_F0_TLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17090">
        <property type="entry name" value="FERM_F1_TLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000028">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032425">
        <property type="entry name" value="FERM_f0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015224">
        <property type="entry name" value="Talin_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036476">
        <property type="entry name" value="Talin_cent_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054082">
        <property type="entry name" value="Talin_IBS2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049108">
        <property type="entry name" value="Talin_R4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054060">
        <property type="entry name" value="TLN1-like_RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015009">
        <property type="entry name" value="Vinculin-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16511">
        <property type="entry name" value="FERM_f0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21896">
        <property type="entry name" value="Talin_IBS2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09141">
        <property type="entry name" value="Talin_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21692">
        <property type="entry name" value="Talin_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21865">
        <property type="entry name" value="TLN1-like_RS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08913">
        <property type="entry name" value="VBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109880">
        <property type="entry name" value="A middle domain of Talin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="5">
        <location>
            <begin position="158"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="6">
        <location>
            <begin position="2125"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2333"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2341"/>
            <end position="2354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5266.t1"/>
        </source>
    </evidence>
    <sequence length="2354" mass="257617" checksum="64BCAF31BBC04D01" modified="2023-02-22" version="1">MIRFYFLPLALLYHFVHPTDRMEKSHLRWALEGRECCFAVVVEVLRLPFVPSFIVHSALFIFILTGIPTDFMGVLTLNIECREKGIKKTMQFEPRTLVHDACRLIRDKLGHMPGNPNDYGLFRVEDDPTKCVWMENGRTLEYYLIRNGDTLEYKNKIRPLRVRTLDGGAVKTVFVDESQPVSQLMVVICSKMGIANHEEYSLVRGTAPEGTDGGMENGLSMAEREKTPHINGSDEPRPKQRGLENTFMNTIGRKKERQIQQLRAKLHTDAEINWADHSKTLREQNIAEDEQLTLRRKFFFSDTNVDTRDPVQLNLLYIQCRDGVLRGLHPVSRDTAIKLAALQCYIEYGPYEEGIQRSVDAKNLLPKEYAKAKELEKNIIQDYRELMYEDSAAPKKKYCELCQSLPTYGVTFFLVKEKLPGKNRLIPRLLGVNKDSVMRVDERTKAVLKEWPLEQVRRWAASYKTFTLDFGDYKDGYYSVQTLEGERIGQLIGGYIDIILKKKRIVDSGGIEGDEGATMVEDIVAPAKATLMAHSDLAPAYPAQEGYLPNGTLRPSTEKPAGAPQYGGVSGMIIAQEMPKGERIRYLDARERSQRALIGTIEATIRAVEEAEEEIQKPLQIDLPQFAETQRHWRVEVEKEAVSDRLAAMGAATAEVVQLTAIPEESVDTRVGHAIATIGSNLPEMGRGVRQLAAIMPNESRAGDLMDAARKLCNAFGDFLEKVHPEKQEKRATILSAASRVGELSHDMISTMQEQTEEERIFHEELNRRARAVATNTAQLARPHIRTQQPLDSLIRECADVSRYVSPLIKRIKQHQGTTEAGAQFRAKVGLIHDAQAVVEPATRLVDVSRSSVSHVGDKHSAGLLLHNTQQLSVNVAELRTLLSNVQQLDFGPQLEHSEELIRSLDNQLQQLSQRIRHEQPLHPSPATLDIQQQTTRAFRQQCRLLNSTIAQMVSATHSSESRQIGAAMLEMTQALSDFTDSVEDVASTATTGESDFAGGEERAESLILNALSVVHNSGNVFGKVREQSTAQQLEEAARRVTESLRKTLASLPDNVIVDRAVDRLKSLNIQTARTSPTPSPSTADLHAIATTLTESANRLPTLLHSSAEQNARGATQSKDSMGQSVGAKLLGEAKESALFTLESLRVAQTDPNNASFSQSLSSSVRQFVSTISAVVELAEANGTSAWVRECEDAIQQIHSVRHLFDGATMTPLNVPLNGNSYYESLAEVTNEARNLGDGMNGLAHYARRNDNEQLCLAVRQVANAVCGLAKNAAQSAYLIGVGDPQSEPGRAAIYDVVRCEQSLQSVKHLTEQICEGQGDKPQIINDTTMLASHASVLASICRDASEQSANVGVRSQFVHCAREITSVTATLITAVKQFDQSEKDADLAKCAEQSRKLHAAAENLCKFIDNPDFGALPARISAAGRRAQQPLVLSATKMLDASFDMITTAKSLDENPSDATTWQQIANSSSVVSESIKQLVAAIRDEAPGQSDLSNATNILMQLLQQVDDATIAAAREELPRADTSVDSTHQQILHSAQQIMNSIDPLKISAISHAEAIGRNVRQQIASIQTLVAASVQAASLSYDSRTQSNLFEQCKTVLEASLQMMYATKDSGGNPKAVELHTIVEESAEQQRVALNDLQRQVQLLDSESGVVVGVIDNISRSIALVDQTRKPSTTDSLANIQVQIASILNEMAQNASNAPLTQPQQLGTLSLRLSENYRELVEAVQIAQNLMSSPELSQKLKMSVQKLGTVLIELVKLGAQRRNYPADQRVYQQLSQHSVLMQERIREVLAVLSEGSQGTQACINAAQTVSGIIGDLDTTILFATSGSLNPLQTSGELVDHRDTILKTAKALVEDTKALVSGAASNQEQLAVAAQNAVRTILQLSEAVKCGAATLSSDSTEAQVMVIHAVRDVAAALSNLIQATTHASGRSPNDPAIGNLKEAAKVMVSNVGSLLRAIKTVDDTSQRGAQALEAAINSIEVALKQFESNESTGRRTATAEDVVRASQSVTHAATKAAGASSLLHQENLIAAANLARQSVSDLLSTVRAAAATAENVELKYRMLNSGRDVALQVKYLLATLLHLMTRPDDPNTKNAVLTAANEIAKMVGELARCSEQLRLNVSMGATAEESVIAAGNELIVAANSVEAISQKLAQICPREIHKPDENLTYDEQILSSAKSITQAVQTLVKAASSAQRELVAQGRMSDLPGPMFTSDEQQWTAAANGLVQGHSTEEKLIAAAKQVASSTAHLLVACKVKCDLNSRAMQRLQSAGHAVKTATEHLVNAARQAITQEDCRGLIISQKIVTGITQMMDAHEEVLRKERELKDARNRLAQLNRSRYEKSPELSPEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZV5</accession>
    <name>A0A914HZV5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZV5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5607.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5607.t1"/>
        <property type="gene ID" value="Gr19_v10_g5607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5607.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9184" checksum="AED44075686E530B" modified="2023-02-22" version="1">MFLLGPQFSTNCPQGVHPKVSSNYCSLKLSSPIGQCGPLENSENAFLRIISSLLSSHDASEGTFGMAANATTRQSGGGRRGSKTAGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I275</accession>
    <name>A0A914I275_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g5927.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5927.t1"/>
        <property type="gene ID" value="Gr19_v10_g5927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5927.t1"/>
        </source>
    </evidence>
    <sequence length="1353" mass="152233" checksum="39EEFF26B3F0FA33" modified="2023-02-22" version="1">MTLRTSMTGAERGLDTPLFDAFIADTPYFQSITELRKYDRSLRDQRRALETILPRANPSPSPAPSLVHLPKTNLPEFSGDCTNYTSFGNTFKAGVHDLNISDSLKFMYLKQCLSGSPLTLISSLPVTDASYSSALGLLSQHYDNPEEVARALHNSLRNLPRVRSGESFCGDLRALLDQLECICIQLSQQNQSYNTIGVQMEVEERLPRFILDEIFQAKETDADWSTDKLKSRLRAILKRKEQIQILTPKSRRPPLAPVPQPFTLFSVQRSPPASIVPFDRPGGTASLPSRSAPNIPPEPRQPYPPPPPRVYRVGLLDDGSDYSYINIREAQSLGLPLSPTSVRLGVFNSPHYKDVPAFSTQFGVRLLDEGIGIRDSPNPPSSDESVLAEFTKSIGFLGDRYQVKLPFRAGPDSLPLPSNFGLCLGRLRSVYNTLSKDFSLLNRYHEIISEQLTLGIIEPVPQPGQFSPPLHYLAHHPVVNPVKNKVRIVYDGSAHIGKELSLNECLHPGPPLVPDLVGLLLRFRIPRIAIACDIEKAFLQVSVHPEHRDCTRFLWLKDIQILDPDRPHIHSTVPICRLPLDQSYQLHGFSDASAVAMCAAVYLRGSHPSTPSSKVALVFSKTKVKPAHKGTVLTIPKLELIAAEMASRALTFTQSHLSHLPLDPSLHLWSDSAIVLAWLNGQSPIKDVFVQNRIIFIKSLPKLTIRHLPGKENPADVGTRGVSSLPALEERRIWWSGPEWLSGPPKCWPTNPEIKPYSSTKISAPSTPTPPPPQLFSFNIVQAQRQAPTFDLARFSRLPKVLRSAAYFFRFISRLKSRNTNATPVRFPSLLISVAETRSALLFLIRQEQRQHPPIDRDNLALGIFTDPQQLLRSKGRLDKSRLGDNTTQPIYLSPKSPLTHLIIYETHLCNQHTSPLHTLSLLRLRFWLPKGRRTVQRVISKFCLPCRKFLVQPFNLPPFPPLPEDRVRVSPPFSKVGLDYCGPIYTNVPSQSSTKTKTQVKNWIVVWVCLPTRAISLDLVSDMSAPTFLLSFRRFSAKFGLPAVIYCDNAPTFVSFRSFLQSQSSTSWHFRAPNAPWKGGHYERFMAMIKFHLRRTLSSPSRPRTLPLDQMLTVLSEIESVINTRPITFDSSDPLNPRPLRPIDFIRPLGYRQNFPLAILEDPADPTFTPVETTQTSLQTLWDTLSRRTQNFWTQWVRDYLPSLRERFKKLNRPSAQCPKTGDLVLVQNEALPRSLWTPAVILEVHRNEENFPDTATIKFPSGHVTLRSVAHNSPQQCPLHFRSQGEMGYTSPHPTIHWPAGVSSRQYSPLNYRSQAPLGIAAPCSTPRLSSTSLGKHQPVRRSHDQRCPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I381</accession>
    <name>A0A914I381_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I381"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7089.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7089.t1"/>
        <property type="gene ID" value="Gr19_v10_g7089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7089.t1"/>
        </source>
    </evidence>
    <sequence length="629" mass="69370" checksum="F88E9B23DA54D3D9" modified="2023-02-22" version="1">MTFLNVWHSLLQWGTRTLRSLCTNSFQLCIGYDTMKIKLKARTSSTAFVVGIGSFMAYKLFCRMARSNCLWTTLDQLVQQRTLATLVDPSSTSPSRTVELTEGFYAVRLGGENELLRKLDECLCGKDSASTDVAGTARQDEKVAVVQVRHGSTLRRLIRQNKRVQREGIEALQQEQNATEGILMRGERRHKQERDDDEESMISGISNLTSASRIKPNPHAVERVPPLQLPQEDESAAVTAASSSAVSTPMSALLHCPNADEELCWENEFSSASEAGDAVDARQTDDEMGEPEGLFLFRERCNSLGSISQLSAMKNLERMFRGMPDWHAEPNIDECHLVGTQLQQQHQLVDTALDNLRDLDRLESATNVSSSMASSRLARRCWLETEDGTNRPAAAAFPREAYKIVGPKSDFDFSEMSSICSRSQLIAAERGRKQQQHFSACRSQGLWELCGADVDRRNSSRFSSEKITIGASGDDGTEQYQKHQQQQLLTPMSSTGISSSTMVDSVISCHSSLASTSAFSTRQRSCTDDGAGGGDAGVMFDSAIVSDSAQSNLGLGDGIEHENEDDFDGLSRLAKDGVIRRFCPPNAAAQISDHSTPVRQYQKRAVAATQQRRRGSSAHGSENSLEWFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3B1</accession>
    <name>A0A914I3B1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome non-ATPase regulatory subunit 9</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3B1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6922.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6922.t1"/>
        <property type="gene ID" value="Gr19_v10_g6922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037526211" evidence="3">
        <location>
            <begin position="16"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Nas2 N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6922.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25525" checksum="C4A463410C035D10" modified="2023-02-22" version="1">MLLKFKFNLFAVTLPAAIVDRMQNSDSAEKAKVLMKELEEIDAQLQRHGAQLAENNIGMNEPLVDENGYPRNDVNIYLARTVRHAIVCLQNDRKEKMKEIDAALLEVHAQTRPEHGEEMETDEQQHQQIVHRTSNNPFVQVDGVSPDSPAQAAGLSKGDLIIQFGPLHADIFNKMNQIKDVVERNVNKPIRITALRGGRVQKLQLVPHAWNGAGLVGCVFIELERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3F8</accession>
    <name>A0A914I3F8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3F8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6251.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6251.t1"/>
        <property type="gene ID" value="Gr19_v10_g6251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037895396" evidence="6">
        <location>
            <begin position="24"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="214"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="909"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="858"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1084"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6251.t1"/>
        </source>
    </evidence>
    <sequence length="1119" mass="127777" checksum="174AAA0E37121601" modified="2023-02-22" version="1">MQSPFVLLQLLLLLLQVLPALFADRKEVYFNFTGAVIGGVTNGNAYNVKVECSVCKKTVQEILTEADGRFRFRLLLKKGCYSVKMLTVTATSQMPLGEKIRSNRWALDNPNSSAFYAFFMGEFEPKNRLLFLRGLFTSELPNLGEGMAYVLRLTSQDGSIIYGTTETCNDSRTEWSNKDEGIILKLNKDGLEYEQNTAKPIMTLRLYKINASQCSICQYVFRKGVEPAKKLHNCVHYNHRICIKNLLNRGGDNRFKCPVCRTDIAYIKCGENDDQSQDTAEVVTHELDAEGNVHEKHVEFISNTEELEQQMRQYESHQCETSVDQTTHSDGNVAYFQEPNLPLTELFAFNIVQPVLQNGGGERPKFVYEFATNYNALSRPTKLMHGQTIKIDSADDTEDEMLPPAEGSDNDPDLHAVRYIPDVDNPPSPPGSDEIEAGIRAPIETPAERSDTGDQQQPSAEYVEDILRVMEEPNRMQKQQEKIWEQIKRERAAASDQRSSAAASPVRDISNSDTEPELLEALREVHKRASAQQKPFRERGHTTRPPPPAPPASQRRRASEDAGHQLWEALDRRNQHRMFHQNRLNQRRGKIKVDGNTANVEYFADYQLLFFDIEVRKMSQTDSNLNFLPFVEKSVEIKDAELYTFFMGAHFNLSIAETATVSEMPGTRLRLRRIEPLNYVVQVNCHGEKTDGYRSEPSPNNERNFVVFLPGKRCTKFDIYVGKVDDHAQPNKLLARAVESGIEIMSGTMYIFEKAFEEDKNANYQCQQQQQSESTNNTYEEDIEKAKLESIKEHIKRKGKQKMGESEILQAETSKLSHLTMSSPRQMHFEEKGEKEWENLETKSEIEEKEKANQISKIEKLLAQFKKLDLENEGKKERKKSLKSNIKAYDDQLTDSEAIIEENKIKRSLRRKTRHQFQAASSPDSATQQKGINVEKRRSKMKAPQEVNSEDEFKTPVESETDLEIEHNAKINLKNKKNAQNKVYENVNAVKSPKYNYGKVDAEMESDQIEFEEQKEEKIRNVTEILTKMLGSENLQQVVHQAKHSPSGQSPAKKLYEAAVKENKIKRVKEIVANNGEAFSATSSERDKNSSESDKNCSKHLEMLKAMLKKQKKSGKAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3T6</accession>
    <name>A0A914I3T6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3T6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7051.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7051.t1"/>
        <property type="gene ID" value="Gr19_v10_g7051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7051.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22619" checksum="4FD303E59BF5F803" modified="2023-02-22" version="1">MCFCHQRRVLHRDLKPQNLLVDPEGQVIKLADFGLARAVGIPIRAYTHEVVTLWYRAPEVLLGAARYSTGIDIWSIGCIFAEMSRKKPLFQGDSEIDQLFRIFRILATPNEAIWEGCTQLPDYRPTFPKWSGNHLSAKMRGSTLDELGLQLLLKMFAYNPVDRISAKDILKHAYFNDLKKQKLPAGDYDGTLVLPAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5B1</accession>
    <name>A0A914I5B1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5B1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6921.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6921.t2"/>
        <property type="gene ID" value="Gr19_v10_g6921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF7">
        <property type="entry name" value="GLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="532"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6921.t2"/>
        </source>
    </evidence>
    <sequence length="888" mass="98189" checksum="673721E7542B1928" modified="2023-02-22" version="1">MNKIWHWFRGDNDPKFWQGAAASSDKRRWRSERAMSRTPAGAKRVGADISRDFAAVQAASVSSPTVLLPSKSVKTVQDRLVLINGHEKRPPKSSVRSAPWPANDQTKPPIPLSSSANQKGSRRQKSRGIAAAAVTTEDLPDKVSTSTRIRQHFSKHGGRRSDMAKLDNAVLSERRMTVTMTMAVETCQNGGIEQQQHIVVPMTQQRRGDYRLGGDSARSGDALGEDDVSQGRCSSFDYFSATASPIDRQPVTERVDVEPRINNENNEDELRFATAAEARAYLRRQHGGDEEEEEQESCDADDEITTATTSAMCDSLLVQRRPHSAMATTVGQHESVYFTATVMVQSATTPDIVRRRPPLQQQKGADQRSLRGLPRQKSRSQIALCDHDESAFGGTGGGIGSEPSSTKFARRRLRFVIPQVSICDAEGIPAEENVVNNINNNDSEKFDDDNEQVLGAMNVEDLANNNINSENKANLSGPEAEHESMLTEQDKQLRKALSEMDRRQLTLAQRRQSNMDVVHQASGRRTSTTLIPLTSAQIHLIRSLWRQVYLSKGPTVIGSQISHRLFFKEPETRELFRRCVLPQQFANHDSFSKAHCKQISELIDQVVESLDDLEHVGPSLEQVGRCHAHISGGQLSSKLWNSVAETFIDCTLEWGDRRARSETVRKAWALIIAFMVERIKHGHLEERRHISAIRSTIASLERAAMASTTVQHPYYEVQQPTTSSSTQLPVPVSSFCHPIRRVSAFTTSGGVPDNCRPGSGVIRGMFSCNLKLSERAEKKNQHHYHHRRSSSSSGHQSPQIGSVGTVRRKEGAGLAPRASRTDSARMPTTNAVPPLSLGSMRKKMSVSDFVPARKQNSKSSTGGSSTGPTSESRTYGNGSHQTQNKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5T9</accession>
    <name>A0A914I5T9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5T9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7043.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7043.t1"/>
        <property type="gene ID" value="Gr19_v10_g7043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7043.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21346" checksum="308016D346574EB6" modified="2023-02-22" version="1">MAAEDAQNEARECVRTTIVNPQSFCFDHLLRLSAVNDLKKADPLLFEALTIFVYGSLSDYRRFIAAHPTFVRDELRVENEETLDIKIKQLTLISMAEKTQTISLLELAKNLDIPDNEDLELFLIDAIHANAIRGKINEIGAELVVDSHQQRVFESAQWEQLHTRLGGLLENVRWFRDNIRSVVEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I630</accession>
    <name>A0A914I630_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I630"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7845.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7845.t2"/>
        <property type="gene ID" value="Gr19_v10_g7845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7845.t2"/>
        </source>
    </evidence>
    <sequence length="1130" mass="124912" checksum="0970DBC30B4286D3" modified="2023-02-22" version="1">MSREVGKKGGKGQFGVMEGGKCNPEILQNWEGFEDTYDSRSSAVVPHISLLFFLAFFHTFGHKTFVNTILKMYTNNDGKNLAGLAWDDFFRVVDHQQTTNFAKQSSLLTLSKCNDDVAMLPHKKATCYGSCSVTEAPKLVKCQSCNLVVKIVAFGHHQKIHHNHFCSPTRRSISSDSDSDDDCQGFLLSPPHHPTPNVFSSSETMLDLKIIEDTKWTLSDSLKNHPINDERKVRNEKNKKVSRQSPPRYDVQQRNDLRLVLTKRRNSIAKTRTHKDAVDQNQSAPLVSISITRSSGQKRNFFKITKRDSTSRQTPVEANKLTEDIFTADLEESEQSSIPLHHSPSESSNSDLEGNEQDDEIGNELFESYPVRLRSFVREQCPIVPSVANAVGWDPRKAAERPSAANKTNNMTLLHKMQQKSEVGLQQSESCNDGALEKVLEQSFALKRTAGKERDRPTERSPENSGMNVVVEKLFKIQGISVTALSPDGKRKLAVSTKQNQTPPYTEKGENVGVGTDLLNHRFRIENGSTCQKVPLSVAQQQQETSKAYFQLRNSSPPVTSFSSSNASVFDKSSPTAKNGDLNAMGIEGGNELQKSGGNSPADPFFAKSQTAQRKASASFAGVSWRKLNSVPVAQMNGSEVPMALPPKGTLRFMPLPNLGASGNVAEQRQGDTNTQPKRMERPSPIVQPSSSPSQMFAEKDDNSQLMDIDSKRHQSPEIVCYAQQSVQRKSDGSPASSAVFLDQNVIRKRNFPHQQQPMQQQTIVAKRFRPIAPRKVQSKICAGGPSQQQQNLHSRISNTLAHQQITPNSFGALSVSKRLQPDNFDQRFQPKIFSVFPSSSSVRPCGNVPHVHVDQLPSTEDFRTFGRQSRQMGKTTAAPCVHLHQCQPYGQTDIASSAAQYSAQSLYRHSHDPSYCSPGAFVFGASLHSPACFNAVGPPPVRRVPELPQPQQQQQQYLLYQQQHFHPLAAVPSTQCQHNCTRPSSSSAASFAPPQQNASPSSLHSQFSPCRGGGGGGGGFVGAPSLCSEPSFHSSSYVFQQNQQQQLPQRFMRGQLRQQQQQRVVTYDNEIDPEIFAIEPPPVLEAEGNILTPEEVPVRFEEGAGGGVTTRSESDASDMDLRDILPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I664</accession>
    <name>A0A914I664_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I664"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7135.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7135.t1"/>
        <property type="gene ID" value="Gr19_v10_g7135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7135.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9725" checksum="C73018A79FBF9971" modified="2023-02-22" version="1">MFSMKMNVMNVMNGREEANFSECIFSVLHDEVAMKDDHLQPSHLRPLLLSARRSSPTSLRIRLALLLLIHSFKGHSAEQSEEPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6U6</accession>
    <name>A0A914I6U6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6U6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7845.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7845.t1"/>
        <property type="gene ID" value="Gr19_v10_g7845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7845.t1"/>
        </source>
    </evidence>
    <sequence length="1135" mass="125527" checksum="ADFE8779DAD634B8" modified="2023-02-22" version="1">MSREVGKKGGKGQFGVMEGGKCNPEILQNWEGFEDTYDSRSSAVVPHISLLFFLAFFHTFGWASNRHKTFVNTILKMYTNNDGKNLAGLAWDDFFRVVDHQQTTNFAKQSSLLTLSKCNDDVAMLPHKKATCYGSCSVTEAPKLVKCQSCNLVVKIVAFGHHQKIHHNHFCSPTRRSISSDSDSDDDCQGFLLSPPHHPTPNVFSSSETMLDLKIIEDTKWTLSDSLKNHPINDERKVRNEKNKKVSRQSPPRYDVQQRNDLRLVLTKRRNSIAKTRTHKDAVDQNQSAPLVSISITRSSGQKRNFFKITKRDSTSRQTPVEANKLTEDIFTADLEESEQSSIPLHHSPSESSNSDLEGNEQDDEIGNELFESYPVRLRSFVREQCPIVPSVANAVGWDPRKAAERPSAANKTNNMTLLHKMQQKSEVGLQQSESCNDGALEKVLEQSFALKRTAGKERDRPTERSPENSGMNVVVEKLFKIQGISVTALSPDGKRKLAVSTKQNQTPPYTEKGENVGVGTDLLNHRFRIENGSTCQKVPLSVAQQQQETSKAYFQLRNSSPPVTSFSSSNASVFDKSSPTAKNGDLNAMGIEGGNELQKSGGNSPADPFFAKSQTAQRKASASFAGVSWRKLNSVPVAQMNGSEVPMALPPKGTLRFMPLPNLGASGNVAEQRQGDTNTQPKRMERPSPIVQPSSSPSQMFAEKDDNSQLMDIDSKRHQSPEIVCYAQQSVQRKSDGSPASSAVFLDQNVIRKRNFPHQQQPMQQQTIVAKRFRPIAPRKVQSKICAGGPSQQQQNLHSRISNTLAHQQITPNSFGALSVSKRLQPDNFDQRFQPKIFSVFPSSSSVRPCGNVPHVHVDQLPSTEDFRTFGRQSRQMGKTTAAPCVHLHQCQPYGQTDIASSAAQYSAQSLYRHSHDPSYCSPGAFVFGASLHSPACFNAVGPPPVRRVPELPQPQQQQQQYLLYQQQHFHPLAAVPSTQCQHNCTRPSSSSAASFAPPQQNASPSSLHSQFSPCRGGGGGGGGFVGAPSLCSEPSFHSSSYVFQQNQQQQLPQRFMRGQLRQQQQQRVVTYDNEIDPEIFAIEPPPVLEAEGNILTPEEVPVRFEEGAGGGVTTRSESDASDMDLRDILPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I792</accession>
    <name>A0A914I792_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Complement component 1 Q subcomponent-binding protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAM33 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I792"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g756.t1">
        <property type="protein sequence ID" value="Gr19_v10_g756.t1"/>
        <property type="gene ID" value="Gr19_v10_g756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g756.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28256" checksum="16D7960D494F543A" modified="2023-02-22" version="1">MNRAISLFTRCGVPRMAALLPLSSVSMSSSTIAAAGGGRFVSERGVCTTLQRFNAVQELSSALDEEIKAEKELVQDKLGGDSAPSVHGFNISTNGAEVRLTKTHGNEKIVVQVNVNHSVGIEEDEEYEDESSTTEMETESVPVALPHFTISITKKNTSLFFSLEMVKTEEGGFDFTVEEFFIAPAVNGVAKDDIGDEVYSSSGKYIDPKLHDLLFVRYLEERGFSPDFCQQLVSFVTHHEHALYVAFLDSIKKFVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7C1</accession>
    <name>A0A914I7C1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7C1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7970.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7970.t2"/>
        <property type="gene ID" value="Gr19_v10_g7970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="440"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7970.t2"/>
        </source>
    </evidence>
    <sequence length="731" mass="83816" checksum="22FA67211F67B242" modified="2023-02-22" version="1">MDYPRINERELKFPIPCGIIVSGPSSSGKTQLVLRLLSCADEMFAPPPKAIVWAYGEYSAQIPELERQGIIVHAGAPSDEMLNKLPKPFLIVYDDLMGEIDAKKLADLYTKKSHHNNFAVMFLTQNLFDKAMRVPRSNAQYIFLMRAPNDMLSIRNLATQIFPREQGFLIDAYKQACAEPYGKKQLIGQRVLENYEYLKTLGKTSSQKKIRHLLSSAGCEELLTPRDICFRDEKMANKLILLPIEHYRGLVAAREKIDDDVTEQTNFGFVKQQFEKAKRKRAANVSEKSAMYNQQLRRYLKLRKEVKDKPVKVQLSNGMRLMTKPPATGVQLKPGPEEVEETIVIGGSEADDDETATISTPKFSTPKEVEVGPEPRPSRKRDLKKQEIMAKEQQLLSIIKSDPKRFGVNARDKIINPSTGREFIDFDLTRAIERLVNPRPENAPSPSDVQADLADFQALSRKNLGNRYLLLAVDVLSRRMFGAPVKSKKPADMKRAFEELFGQMPKLPETLYTDRGLEFVAKPLKEFYAEKGIKKFETSSKKKAAVAERAIRTLKTRLYKYFSAKNTSTWVDVLAKFLAAINNSVCRATGLRPNDIDEQNAREVWKKVYGEAIEPSSKGPKIKLGENVRIPEPKHIFEKGYMPNYSDHVYTVDERRSSKPEHYFLKDYYGTKLKRKFYLPELTKVKVDKNTLYRVEKKYKERMRGGQKEMLVKFIGFPEKYWVTSDDFVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8D3</accession>
    <name>A0A914I8D3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8D3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7586.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7586.t1"/>
        <property type="gene ID" value="Gr19_v10_g7586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF2">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765347" description="Domain of unknown function DB domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="65"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7586.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21612" checksum="F4E9C83AB671F238" modified="2023-02-22" version="1">MEDGPGEEMAKRQNIFVFFVTVALTAFGLAEEVSEFEQPVDCGTAATEWKPCIERRVADQVFGSCCERFVPPECRGLCTYESHPIEARILLMHTIQPSRCRLYKYLSAIVHCAAQTHDNTLCCREMGLQEIGQSCLDLCRPQQNPRERWGVKSLRKDLVQCLSKWDQALFCHQAGLRSRKIAKFVPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8G0</accession>
    <name>A0A914I8G0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8G0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8252.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8252.t1"/>
        <property type="gene ID" value="Gr19_v10_g8252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8252.t1"/>
        </source>
    </evidence>
    <sequence length="1054" mass="114436" checksum="0DDF3B9CEE67FE9B" modified="2023-02-22" version="1">MNLIRMPYQSISNFIPTSPSCPSPTSSPRPLVSISNFIPTSPRVHLQLHPHVPSCPSPTSSPRPLVSISNFIPTSPSCPSPTSSPRPPPFCPSPTSSPRPPPFCPSPTSSPRPPPFCPSPSLSPRPLVSIFNFIPTSPSLLPISKFIPTSPRVHLQLHPHVPKCPSPTSSPRPLVSISNFIPTSPRVHLQLHPHVPLLPISNFIPTSPRVHLQLHPHVPKCPSPTSSPRPLVSIFNFIPTSPSVHLQVHPHVPSCHPHVPSCPSSTSSPRPLVSISNFIPTSPRVHLQLHPHVPSCPSSTSSPRPQVSISKFIPTSPRAIPTSPRVHLQLHPHVPLLPISNFIPTSPRVHLQLHPHVPKCPSPSSSPRPLVPSPRPLVSIFNFIPTSPRVHLQLHPHVPSCPSPTSSPRPLVSIFNFIPTYPSCPSPTSSPRPLVSIFNFTPTSPSVHLQLHPHVPSCPSSTSSPRPQVSISKFIPTSPRAIPTSPRVHLQLHPHVPSCPSPTSSPRPLVSIFNFIPTSPSLLPISNFIPTSPSLLPISNFIPTSPSLLPISNFIPTSPRVHLQLHPHVPSCPSPTSSPRPLVSISNFIPTLSPRPLVSIFNFIPTSPSVHLQLHPHVPSCPSPTSSPRPLVSIFNFIPTSPSVHLQVHPHVPSCHPHVPSCPSSTSSPRPLVSISNFIPTSPRVHLQLHPHVPSCPSSTSSPRPQVSISKFIPTSPRAIPTSPRVHLQLHPHVPLLPISNFIPTSPRVHLQLHPHVPKCPSPSSSPRPLVPSPRPLVSIFNFIPTSPRVHLQLHPHVPSCPSPTSSPRPLVSIFNFIPTYPSCPSPTSSPRPLVSIFNFTPTSPSVHLQLHPHVPSCPSSTSSPRPQVSISKFIPTSPRAIPTSPRVHLQLHPHVPSCPSPTSSPRPLVSIFNFIPTSPSLLPISNFIPTSPSLLPISNFIPTSPSLLPISNFIPTSPSLLPISKFIPTSPRVHLQLHPTSPSLLPISNFISNPCSFPSPTEQSYQNLPNPPNLPLPLSTSYFFTRRHLPVLRSHPSFWEFEFYTMPPRGPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8L7</accession>
    <name>A0A914I8L7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-tubulin complex component</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8L7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7647.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7647.t1"/>
        <property type="gene ID" value="Gr19_v10_g7647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037114141" evidence="1">
        <location>
            <begin position="22"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7647.t1"/>
        </source>
    </evidence>
    <sequence length="650" mass="75632" checksum="EA06F86909A0BB03" modified="2023-02-22" version="1">MIRLQTLLHFIFRLLPQSIRCHCKDLFLMAQSVDIILAICRSLLLPTAPPSAPLSEDRQRKFYINWQRWAIDRLYGGGSDHDVVSAWHRSQIEITLQTASELRRKLWLIDEFIANSLSYSNGNFLLGHDALVSPVCAALSFFAEAKTVAGKRLDSEAQFAGLRPFDDFLQTLKRRFSDFPHFLEQLVTSKNVRRLTKQPPIFTFWSDFLQNLNFWPVYETENRMPVWKTTLFEGFVHLLGKYLTLRLKSATDGAEDRLTNADKLDFLESLWADDELTLGRFHFVTNCERSAPLRELEENGHLRPFHEIFVAHWHKFREDGRLHFTQSFLTQLARQSLVHHSVQLDKLLLVHLTRENLLKDQLRFVLNITSLNSFWTREHSLHELLDTEGDVEKRSTEFFARQFWPLRVLLDQHLYQQLFAVSVRLRRIQHALLLVMDSIALSHRREGRFRRQWPTGAIPFVTDDLKERLRRALGTRLMRQLQSLFQLLFIHFSSLNSVCVRALVENAEKQRNDDENIHLNDSLEVVQEWKNALTSLLCFIEDLFREPIDELIQIGNAFSNPSTVSSFDGFDISDNGSNAQDGDDRLEDPEHNFIKTTDKHIPAITCSSSRCTQTDNTALSLMICYKSCRFTAQPVPDEERRVNSQRHGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICC3</accession>
    <name>A0A914ICC3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICC3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9305.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9305.t1"/>
        <property type="gene ID" value="Gr19_v10_g9305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9305.t1"/>
        </source>
    </evidence>
    <sequence length="664" mass="78046" checksum="C3DAE842D20877B2" modified="2023-02-22" version="1">MILSVAIRICAIFGSEKDEYSLEAFLTAYHRANIGRSQQRKIYSYEILPIFNNKNNGQLKHLSDEITSIKFYKTKTDSAERNSNFLLQLSANAETPFSIVEMAQQIHSGEYHKMNMYIDNMKLSTLVIEHFTGDSLADYKKENLPGSSFWASLDVIYINNLSNFMVNLLNRILNSSNLNNYFAHTDLSKELEAEQKFFSNLLNQYNERLDENLQKEIVERGHYLHFEDAIQINWNPHTKMYKLLHVLKHQWFCWNRLDHFVYRFNKDLSADLDDFCDRTGYSSMAYEQNKLLNHLQTLENFEQIKAAYEKCANIGEKNQQPMIYSYKIIEGPTLTFSYMKMLPIYKENNELSLHMSDEIAEIKIYKTPTSSADQNFDFLLKLSAVDLTPFSIVHFAQQIHCSIKQGTARLEYDNVKLSQLAIVHFTGESLTYHKKEYFPGCSFRPKVDAFCIIHLSNFMVNLLNGILNSPNLNNYFVHTGLSVELWAEQVFFSDLFKTYNDGQCVEFNRKKKLIVEREEHYLHFEDAFHINWNPYKEMFKLIQVLKYQCFCSTELYSLGFNEGFENGLRNECEEMRKNDELDGKRPNLGTDTITNDEQNMRLTPLKTLENFEQIKKAYEKLKMFLNEKRYGKCNKKEEKEDGYNAIVKLNEEFGKAFEKVLMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICE6</accession>
    <name>A0A914ICE6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICE6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9542.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9542.t1"/>
        <property type="gene ID" value="Gr19_v10_g9542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9542.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31331" checksum="15AC5ACAE85CDD87" modified="2023-02-22" version="1">MAAEEVVVNMCMEVDSCTSAEVELDKAVGTVEESIVVAVRTEADSIAPAVADMAEDSSSNRRLHRRTGMLMYLMYRNVYPCWPFIIGAIALNLVAIFGMVTNLGVIWTTYCTKTLHGTANVLLALCSFFELLHQQGHLLFLYVALSGQNFISLSMAIRWCTVSLFALGGITLSMTFTGLDRLLCVLFPTFPNKVKPLPYLGVIITLCVIFSLQNVMNFYELASTMPFLMVPGTIGDLMKGDASQSLAIKSLILNTITIFLYVIVGIVISKKSVRVLNCPMRKCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICP3</accession>
    <name>A0A914ICP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9617.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9617.t1"/>
        <property type="gene ID" value="Gr19_v10_g9617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9617.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16401" checksum="DCB9691229732705" modified="2023-02-22" version="1">MRLVLENGRVDGAGRPMFVHPTSKTAAWKIIWHQIWPLISDTFAAFIWVSLNSTICGRFSPTVLGDCAKLRMIESLIFFPRSRPLTVPALLLPKQWPSGCTRPAGMTSEGIVNSTDPSNFIIIFGSVLLTLCHLTGKQFDGGALEFAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICV8</accession>
    <name>A0A914ICV8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cGMP-dependent protein kinase egl-4</fullName>
            <ecNumber evidence="3">2.7.11.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Egg-laying defective protein 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914ICV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8746.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8746.t1"/>
        <property type="gene ID" value="Gr19_v10_g8746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000096">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000072">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000064">
        <property type="entry name" value="cGMP-dependent protein kinase, isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032375">
        <property type="entry name" value="CCM2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF111">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16545">
        <property type="entry name" value="CCM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0140">cGMP</keyword>
    <keyword evidence="11" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="579"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="697"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="855"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="1116"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1138"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="455"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8746.t1"/>
        </source>
    </evidence>
    <sequence length="1166" mass="130732" checksum="F8850CDBFF815054" modified="2023-02-22" version="1">MAEVAPEQRRWTLRLGGLVEAVNGAHIDPSGRTDLLKVLDRAKRDGTFPLDDGEMALLECDCDVLRVSEAPEGNNLLALIPLHQLSSVGFVREAPQNILALKVGDVEEGKPDLFDLIILFTPTEEIADEICQHLAVCFQFVYREALSTLEEDEADRDTKDCPQGDISAKFVPAAPSSATSSSLCSLPPSPFPSPSNHNNQPASHQRLLASVDNANSTSTSSNSTKQVVELINEYLTMLSACLSHDELNKFAILMRRWRAREMPILEFAQKLLELYGPERRHLLARMRTLLRGDPSELEALTDFLRANGVVENAAAMAASPLLTAEMSLGEEVNSSKSTASSLPSAPLLRSPNRLTKLAAKRLHNSLEDEVAAVKIGKLAVSTAQEQNESMSSSSQLHVQNSGQSHSAGRQKEGGTGFRRFFDKLRKPSEIIVQIGSRTYDAQELQKLVPRMEGELEKQDRLLRQNQKELDAHQKRIGELEVEVKTLSSECDKLRSVLNQKAESAATLGGQKRSDDLHTEMKQAALLPEVGQVVPEVRAKKMAVSAEPTKLDQHKATLQHHSKSAGCKQLIRDAVQKNDFLRQLAKEQIIELVECMFEMRARAGQWVIQEGEPGDRLYVIAEGQLQVSREGQSLGVMNPGVAMGELAILYNCERTASIQAITDCVLFCLDRSVFQMITMRLGMERHAQLMNFLHKVEIFVGLPEDRLSKMADVMDQDYYAADHYIIREGEKGDTFFVINSGQVRVTQSIEGELEPREVRVLKQGEFFGEKALLGEEVRTANVIALAPGVEVLTLDRESFLKLIGDLEPLLKQQRAYRDEDIKRRSARTEKDARVSPIKTEIPELEDEFAQIQLRQLKRIATLGVGGFGRVELVCINADKSRSFALKALKKKHVVDTRQQEHIFAERNIMLETRTDWIVRLYKTFRDSKYVYMLLEACLGGELWTTLRDRGHFDDYTARFYVACVLEGLEHLHRRNIVYRDLKPENCLLTTSGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGIDVLEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWDGLRSRTLKPPIIPKVSNPADVSNFDNYPPDQDIPPDEFSGWDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDL3</accession>
    <name>A0A914IDL3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="11">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8909.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8909.t1"/>
        <property type="gene ID" value="Gr19_v10_g8909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003492">
        <property type="entry name" value="AGAP012735-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004162">
        <property type="entry name" value="ATP binding cassette subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="970"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1032"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1121"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1204"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1232"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="334"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="648"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="976"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1301"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="890"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8909.t1"/>
        </source>
    </evidence>
    <sequence length="1513" mass="170412" checksum="7A4BD081B95E2123" modified="2023-02-22" version="1">MYFCEGDSFDLFEKGGESELPRVSQCFQETVLLLIPALFLLLFCPLLLCSFRRSVKSPLIFKPPTTLKIYICIFLVLNVIVRLGHAFTVHLFFVQMVPSNPTRPLARFVCLSLSALSTILALFLLISCKKRGLVTSGVLFNYWLLLSVCGAPQFAWEIGQIFEKHTQKHYITMFLFISYYLAVLMELFLSSYADTQTDQSFDKKECPEGRVSFLNRITFWWFNGMARLGNKRPLEADDLWNLLKQDRSEYLLERFEKIRTKQLKRNNERYSQQKHAKVTLLPSDGMVETELLQMDGAGSKSIMEDKKKTAPNGRGSPSIIWPLFLTFKWPTLRAAFCKLIYDLLHFVLPFFLSQLIAFTEDHTMPTWRGIAIALSMLTVSLIQSMFLHQYFHTMFRLGMNVKSVLASTVYRKAILLSNESRKNRTIGEIVNLMSVDIQRFQDMTPYVMLFWSAPLQVVLALFFLWKLLGISVATGLITLVTVGFLNTKLAVTMRSYQQKQMVLKDERLKLLNEMLNGIKILKLYAWEGSIEKRILCIRKKEAQILKHLCFLLALMSLTWACAPFLVAVSTFATYLIIDPEHNILTPQITFVAISLFNILRFPLASFSMIGSPAIQTAVSNRRLKSFLAEEEIEPLLRDTQNSKISICIKNADFAWEKNQSLLLKKINLSVRKGTLLAIVGQTGSGKSSILSAMLGEMYRHSGENSLDGNVAYVPQQAWIQNMTLKNNILFSHDFDADKYERVIDVCALEQDLVALPAGDQTEIGEKRVSLARAAYADADIYLLDDPLSAVDVHVGAHLFDKLIGSANGLLRGKTRVLVTHSLAFLKHCDQIVVVKDGSITQMGTYTDLLEASGEFSDLIRDFLTTRSSVNSDGLMDKDVQEFLSSIKSKDPEKSKELERQLSQKATLSSSSKTTESEPIAPDPEKTAELTKSTSKKNGPKPSQNKKLIEREEVFTGKVKYSVYMDYLRAIGLWTCLLCLLIYLFSSVLGVACLLWLAKWSDHASEFKTANGSISSSNIINLSIYTGLGLGQASFLAIGAVIMSLGMVYAGYAMHERMLRSILRSPISFFDVTPLGRILNRFSKDVDNLDSAIPRSLSSFIQTVFASMQTLVTIVYATPQFVFVLAPLAVIYGFVLRYYVSTSRQLKRLESISRSPIYSHFQESVQGASSIRAYNSIGRFLRESQQRVDYNFVAYYPSIIANRWLAIRLELVGNSIVFFSALFAVLFRDSEHLTAGLVGLSISYALGVTQTLNWVVRMASDVETNIVSVERIKEYIETPNEANLDTPSELNLSENWPEKGDILMEDVSLRYRPELDTVLNGISAHINPREKIGIVGRTGAGKSSLTIALFRLTELSSGRIIIDAVDISELGLFDLRSRLTIVPQDPVLFSGTLRFNLDPFDHLCNISLGQRQLLCLTRALLRSSRILILDEATASVDMATDALVQETIRREFRDCTVLTIAHRLETILDSNRVMVLQQGRVKEFDSSKSLMNDPRSELSAMVANAKMSVSQQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE33</accession>
    <name>A0A914IE33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9760.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9760.t1"/>
        <property type="gene ID" value="Gr19_v10_g9760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="115"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="115"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9760.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="34235" checksum="FE24A824D7F8FD8C" modified="2023-02-22" version="1">MALCQKFGRLLIGAEARFSARTEFPLGFHRATTRQTLFHFLSRIKCRGKNLSEEEKQSYSERAKAIGDELRDNFEKLTNRQKKDLWDKHVEKRNKLLRLQMKRKQQKFHAETNRPKRPMTSNWVFIKECFEKQTEPIKTRDKVRKFVAEMAQQWRQMTDAEKRPYVDQTQCNFAAYQKEMAEWKQKYANEIRAWKEAEAKAALKARDTQFTEAPLFELNIDADKDLNKKEAIYRMLLDDSTHLVERREWSDDRDVHEEAAAIQRMFLAISTYLGRKKISQNQRIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEV2</accession>
    <name>A0A914IEV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g9247.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9247.t2"/>
        <property type="gene ID" value="Gr19_v10_g9247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="277"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9247.t2"/>
        </source>
    </evidence>
    <sequence length="1383" mass="154833" checksum="D52F54A031341000" modified="2023-02-22" version="1">MDSEESENEKEDPPIHFNTKKSPHIAATAYNKHPHTVHDENDEYHHQHTVDSAGNQNASVVNFIKKLSRNANVGGGNTVFNNKQPLQPSNVVNRQPLHEHAVNLHNKLTSLSDNFGNNLPKVNNAKSVPPLNMVVTTVNKRSKPEHAAPQKVAANAVNKSPSRQPAAHGVNVAIKAPLQEYQNTSSVQHVVKHMPMQALDDVGISKSTRIKAPPPPAMLPKLAAVKTPKIPSNKAPRTPATPAKKRLYTPRNNFEAEIIETRDTLVKQQKRKSANPFKVIKNQQEGSFLDLENIPNLHEVGHLKDKCGHFYLSELKLFKMKNKNGRLNSFYVLPKPVSGGATSKVFHASPIDAVDMDGKQITNCVAIKGKPSVTHIVHLHDMIKDYEKNRLIIILELGKHDLMKRLQLMRNQWKLYWGSTKTSIDVQIKKLLWQVLEAVDEMHSKAIHLDMKPDNLLFVEIKDNFGRKKNEILKVIDFGGSEIIDPSNDKSNEVASVANVCRLRKGMWSDDRYSSPEQNNACLEHGPDIFPISTKADIWSVGVMLAEFLLMTPNFPEIDPIVIKRSSEANNIYNAVLAINHSHYTISPTGNATRKQSAEYLAKMHDIYPQFYAIIKACLNINPRQRPTAKGIMDFLKGKCQFQTDMDVIFEGQRHKRSAHITAQKEHVQRNRPDRTRSEQRVKIVEEQITTSQSQVVTEEHLLPTLNEPDASVVDDTVNSALHIPTITNIDEASAQTTPAHFGLDNVINHPSLDQTAPNFGLNQASASAKLNDESGITPHRLLVDESYGSDSQEQSGSGQRKRRKKSTPPQDRSAVIKKSMQKVHLYSTSESSSEEEEESSSEEEEEQTTPAKASAGKKNAQQPNMAEAMLAFMDKPLLPKQTSKPKNTQQHNMDEVLDLLRKPLPPKQTSKPKNTQQPNMAEVLDLLRKPLLPKQTSKNRTRAPSVDSKKTISTPNAGNDYNKASVKPKLRAPSAVRDFLPNDQASAASQQRDDSSTDEMIPEGYVPKPLGTMKARAIRDRELVSPPAKKMSAGPNAGNGREASAARSPSKTKKPPSERKSSEEESSDSSVEVGPTRNEQSKRTPTPRQASARLGEVNVDADPPVENEDDTDSSNEASAPKAPPRGRKPGVKKSRRRRLTPHQREKPPHGYHDCAACSTPLYHAGKGRKPWIHDEMRKCSRCRKYCCVDDKDDLMKRTISSTNIILRYVARWCGQHQHLLRQYFEKKRRLRDQLADLRTNHPEDAVGIKSLEGSVKAMQEWGSDMPAYRIARYIRDWLYEGSPPLKASAWWAFRGFFYEIGTAPDIPQDDERVYENQVSSELPEMDVPTALTEAAVNEVERAILLDPEASAEDKTTTTLYFPNQNENNCNTNSGGYFQIDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFY1</accession>
    <name>A0A914IFY1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFY1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9547.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9547.t1"/>
        <property type="gene ID" value="Gr19_v10_g9547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244:SF34">
        <property type="entry name" value="DTDP-4-AMINO-4,6-DIDEOXYGALACTOSE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9547.t1"/>
        </source>
    </evidence>
    <sequence length="623" mass="69247" checksum="3A327F4B99B537F6" modified="2023-02-22" version="1">MTKLAIFFCGNNSDCAALIELFGQHLQVKNIGELLDSSSMFKRKCLEGIMKCLDKKLISGIEKDWIVFTVSINQLMELKLSPEKLLRHCGIDKALIIWRHNKQIKKLNEDEYASHSTQIIPITDFQVDLWIKFFQCWPIEVSPIFVQYEELFNAPENDSALSKKLVEMVGMDTVHYYCGNLKNKIAKNCNTLCSSTLHTLPPTLYRQVLLLRIKLPYELADLLPEPEPRICMSTNSAQIIRVVEPYIPLRAIQNVNEALTSKQVSSAGIWPKQLAAKLISIYGFPVAVPCSSGFTSLVLALRSAYIGPGSDVLMPSLTFVAVSNAVLNLERASTSNTRAVIVTHTYGCPARDIELVAAGCKTHGWTLIEDISECVGITTLTSAGDERLLGTFGDYTCASLNANKIVHAGDGGFVLARDPSVGARLQSLANHGYTKNLQFVHFEAAINGKINGLGAALACGVLDNLHEIIAHRRLICTRYRTRMAQLFDKRLLVEMPRCGPRDTPWLFCLHCRSSAERTALRVHLATKGVETRNFFFPLHLEPMFDGAYVDFDMPTAQLLGSVGFSLPTHPGLDIDQIDQIAIEVCSFFNQTINHDDDQTIMLKQQKDNGVVGPTVQSRITELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGU3</accession>
    <name>A0A914IGU3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914IGU3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g976.t1">
        <property type="protein sequence ID" value="Gr19_v10_g976.t1"/>
        <property type="gene ID" value="Gr19_v10_g976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="112"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="360"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="633"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g976.t1"/>
        </source>
    </evidence>
    <sequence length="748" mass="85505" checksum="21B314B8C20DD9DD" modified="2023-02-22" version="1">MESRQRKGGGLKRHWVTEAINFVNEHIPSFKDVFDKETFYKFVLLVLVVCVLFVFLMVKVFKVRVRDYPARDVLRERPRRDWRPANPFQFPWQISASGDGEAAAKQRHVCTLRYMLANFDCVVQAPTGSGKSLAFMLPALQILVQKKLTNVAEDPKVPSEHLCRICALVVAPGRDLVMQLWHLFSPLCKKLGLTALKLHGAGGERKKSAQNPKKHMKGQCVLICTPGRFEHFLEKEPELKKYLKHLEVLVIDEADRYSDRESMSSLTTLLAALPKQRRTALFSATQSAGIEQLLRFGLRNPTRLHVSADTGEVCTDSTGFDVATPNDQQNGETEEGHQTKGGVVPAELSIFYTCVPAELKLLALVKFLRSQKRAKVLIFVSNASQAEYFSLIVPQLLKKDGTDSGGVKERPVLSLHRKMEQKREKVLELFRSTDRCVLFTTDLLARGIDVPKIDWVLHFDIPKLSRVFIHRCGRSARMGRAGRSLLLLMPEEEAYVEFMHTSAGVRMEQCQIETLTEERAVQLRERVQQQSIEDRKILELGSSAFVSYIEAYNRHDCQIICKVKDLNIVGVANAFGLLRMPVIREFRNRTDILRAFQPRMDVRTSEIKYKDEKLEAKRAAMLEQRVKQKMEEVKERQKQRNGRVNGSEKQWAGRMQNSDGKRFEFGGRRRAMEGGRDGREKRAKLVNGREQRGAVPTAAHVQNEGKRRGRRAPSEWEQLQKDEGLLRKFRRAKLSRTELDERMDEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IH86</accession>
    <name>A0A914IH86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IH86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g988.t1">
        <property type="protein sequence ID" value="Gr19_v10_g988.t1"/>
        <property type="gene ID" value="Gr19_v10_g988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036734883" evidence="2">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g988.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16711" checksum="942551AC7CC8772E" modified="2023-02-22" version="1">MHCPRFLATVLMFFICPIVSGEPVLSLGQITLQNSDDKPQTLSTIALTKCQSDYLSALIHRCMIRGAPTMPEGRICFTDEVQLEDAYKLVGYISEMCCLLRCQAKTLERLCCRHAQQGRCRKANCLPIRDQKVLWGLAAPLEHGGDDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GP31</accession>
    <name>A0A914GP31_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GP31"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10036.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10036.t1"/>
        <property type="gene ID" value="Gr19_v10_g10036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="94"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10036.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20545" checksum="87DCAA52A6A2227A" modified="2023-02-22" version="1">MFANQIVTMTQINMIRRALITNRVSQINMIRMTLITNRMTLSASIKFTQICPPAIFLLRRILLVVLPLLLPNDGSPVLPGPPIFEAISHYPSLCYLPPESGMCPPATNRTASRGSKPAEARASLTLVEDAADGDEDAQRHVPLLTRYYFDAVTAQCYPFGAQTCGGNENRFDTQAQCLAKCRIDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPP4</accession>
    <name>A0A914GPP4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPP4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10193.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10193.t1"/>
        <property type="gene ID" value="Gr19_v10_g10193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10193.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12993" checksum="7CEBB8BCE112CB88" modified="2023-02-22" version="1">MENQEINSRKNKKKLEHEGCLYIFHKLNADGDVKFWRCEHQHGDVKCRGRVHTSLNDVVMKTVGEHSCQHSAANVAKQQIVTGIKRRAAETMETPAAIRAHALQQNFVDQIFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQM7</accession>
    <name>A0A914GQM7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQM7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10425.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10425.t2"/>
        <property type="gene ID" value="Gr19_v10_g10425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11 13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038163015" description="Zinc metalloproteinase" evidence="11 13">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="36"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10425.t2"/>
        </source>
    </evidence>
    <sequence length="364" mass="40308" checksum="28449D9671BD1A7F" modified="2023-02-22" version="1">MLRLPPAAICLFLFGLSLGSPKKHRRINPSRWKRQSALTGVQFPQNRWDSNGPIAFFFDESLSEKTRQVIRAAAAFWQNYTCVNFEENGKMPPRVRFYRGDGCFSEIGRNSNQRGIIPFQNVSIGDNCGFFAPVAHEIGHVLGMIHTHARSDRDEFIAIHSENEPNGMEKDFERMSPHNSTNLGVEYDYGSVMQYTGYNQQNGKVIMEAKQPHYQHTMGNAYGPVFSDLLAVNRYFGCGRICLDVQSPHCQNGGFPNPKRCSECVCANAFGGTDCSERASGEGGAPFACGETVQANAQWQTLRGAVEAKADGQLRPAGCHFHVTAPPGQRIELRVEELSGLCSPECNVGALELKFERMTSSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRL4</accession>
    <name>A0A914GRL4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10750.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10750.t1"/>
        <property type="gene ID" value="Gr19_v10_g10750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10750.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15025" checksum="2EED72EA7FE3EB63" modified="2023-02-22" version="1">MPRGHKLTTNYDWHTQTAVIGTAQEVPRGWVRWTAQPEGMGSMDGTARGDGFDGRHSPRGWVRWTAQPEGMSRLMRIVSYKMVMGSTKGSSPSVPDPSSPSRASILACNARRATSLRAWSSPARVRRAVASRTDAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS34</accession>
    <name>A0A914GS34_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GS34"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10252.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10252.t1"/>
        <property type="gene ID" value="Gr19_v10_g10252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10252.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23216" checksum="FCB18C6F867EB3FE" modified="2023-02-22" version="1">MSHSHLITQNHGICAEYGTESHHSHRLRQESVLVHCLAGVSRSVCLCLAYLMTVTNLDYPNALDFVGRRHYCAKPNFGFKMQLIKFGQQFVQRERQRLFAEFGHCTDQLQELFRNDCIFTNSLFVCGTSTTLGNAFAVADRQERPPPPQTEEGRRPDDGTSGSSNSTSNPTETGDGTAQQQMPMPFMDDEFEADDLHRKCTAADSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSC9</accession>
    <name>A0A914GSC9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10763.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10763.t1"/>
        <property type="gene ID" value="Gr19_v10_g10763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF129">
        <property type="entry name" value="CAROTENOID OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="864"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="876"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10763.t1"/>
        </source>
    </evidence>
    <sequence length="898" mass="102332" checksum="347BD11A1A0DE6E6" modified="2023-02-22" version="1">MDLRTSMSKVVASGDNDLAAFPFVQTKKEESDRPAVTSLKERVYWLQLLFLLFIQQPQNRVVFAQSLRNVHLGFPEAWDGDKFPEIYCPSKNIPKWLDGYFLCQLSAAYGSPSAPPGQRLMHMIDAIGAIGSFHLSGGEVVFSARYYPSRPYRIWEFYDRNMSKASVPWAGWSHYNLSAMARWEQVPPNPDAARFHPNLDFWRIGRRIIAGTEAPYWVGYEFDIQTLSNFRMASFVEENDIFGGSARPSLIPISMAMHERADSAGPDGLLWGTFSAMNFDEERFFQGLFTIDPNGVRKVVGMYDYGMWDAKACSKEDEYIGDKSRLPGYMHSISSTEHFIILPITSLVINPCKFKEPPRTESAGPHIQEGGLWGMDFYDMVPMRFLVFDKRTNSWVTQKPLEVFPSMFVTHQLNAFEDLEGNIVADMVVYDSHDPYVKYFYTDFLRSQLYPNTARILRFTLDLRTFRVMYSYLIPQEMISADFPQVNHAFDSRPYQWAYLVENPFAGGNKIIKINVNEPSGAKNVRFVPDELQLVMHEPYFQQRPGATREDDGVLLVKGLELEENKGVLLIIDAISMEEIGRAFVPISVPFGFHNRFFSSEQLGLTTSEVSSEEMKNGHKKKKTSSRPPPTMHRTFWERLMNNNGTSTVSPIRAVSWQPIQPSEVVDQQQESHEDQQRVDRLELGAIPLLPGPTPLPWWPTRPVRPTPPPLFSFSPPPSTLPYHTVRPSGPPPTVVQPIPFAPPPQSSEFLPEAKVSELRRPLHARKTNAPMTVRQLYERTLRALCRWISKVFTSISYQGCVHSGQRAIKWMSPTAQRMVQQHAPAVNTDAELLELVDVEQHGESSVAVEDGKLRPKLLVPDATRTPWYATPSGRRRTESDDNENRNGERCKQTAQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSW2</accession>
    <name>A0A914GSW2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914GSW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11069.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11069.t1"/>
        <property type="gene ID" value="Gr19_v10_g11069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11069.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="45575" checksum="796A64BB91633DBE" modified="2023-02-22" version="1">MPLRYISSSTTHSDGIRNQTDGNALCGTKPWGHINTFSTNLRAKMEAEDSAATTAAAGGTSPTTNRSVSGGDVATSTALHGGDADSDDAKQTAREMDEAVASAAGGGARITDLDRQIETLMRCECLTEQEVKVLCAKAREILLQEGNVQRIDAPVTVCGDVHGQFHDLMELFRVGGQVPDTNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRMMLIRGNHESRQITQVYGFYDECFRKYGSAVVWRCCTEVFDCLSLSAVINGRIFCVHGGLSPSIETIDQIRTIDRKQEVPHDGPMCDLLWSDPEESVGYGVSPRGAGYLFGSDVVKTFCEKNGIEMIARAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEQLNKDFTIFEAAPQENRGAPAKKPQPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTV2</accession>
    <name>A0A914GTV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTV2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11199.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11199.t1"/>
        <property type="gene ID" value="Gr19_v10_g11199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11199.t1"/>
        </source>
    </evidence>
    <sequence length="445" mass="48396" checksum="8D37779A1C844B0E" modified="2023-02-22" version="1">MTGVVHLGAHGWALTFGRSRLGAHVWALTFGRSRLGAHVWALTFGRSRLGAHVWALTFGRSRLGAHGWALTFGRSRLGAHGWALTFGRSRLGAHVWALTFGRSRLGAHGWALTFGRSRLGAHGWALRLGAHVGRSRWCGGAHVWALTVGLVRSRLGAHVWGASRWRSRLGARLSATRLGAPFGRSRLGDPLGSHFWALHGWALTFGAHVWRSRWALTLALTVGPSRLGAQFGAHVGRSRLGAHGWALTFGDHVWALTVWALTVGRSRLGLTFGRSRLGAHGWALTFGRSVWALTFGRSRFGRSRLGAHRWALTFGRSRLALTFGRSRLALTVGRSRLGAHVWALTVGASTFGRSRLGAHGWALTFGRSRLGAHVWALTFGRSRLGAHVWALTVGRSRLGAHVWALTVGRSRLGAHGWALTVGRSRLGAGYVWAPTFGRSRKCVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV59</accession>
    <name>A0A914GV59_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV59"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11075.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11075.t1"/>
        <property type="gene ID" value="Gr19_v10_g11075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11075.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22634" checksum="C83BA71A19C32F21" modified="2023-02-22" version="1">MQKTQNVGRLLGPPPPPRLRWTSLASKFDRRPIRPARRQFGQSAKSRLKKSALRNLQISYHLRTLTALLPGVKTGIPRIRTLRLANRYIAHLGRILRGEHIFCEQSQAWRLLTIEDFGRTVGEEMQTTNSYKERAELELLSSCSASSTTTTTTTVGGRAEMTSPDGDVGTAAHFAAHRPVAAAFSDQRAKNSSKIDPFMSRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVF4</accession>
    <name>A0A914GVF4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10758.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10758.t1"/>
        <property type="gene ID" value="Gr19_v10_g10758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="61"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="546"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10758.t1"/>
        </source>
    </evidence>
    <sequence length="747" mass="81102" checksum="4C6E27BB05D12BE4" modified="2023-02-22" version="1">MGILGKYHLCAVRRLHTSICRRSTAVPMSRYEPNSQLPYEKLEANLAIIRKRLNRPLTLAEKIIYSHLDDPQNQKLERGVSYLNLRPDRVAMQDATAQMAMLQFISSGIPRVQVPSTIHCDHLIQAQVGSDKDLYRAKEVNKEVYNFLSSASNKYGVILEHYAFPGLLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGLPWELKCPNVIGVKLTGRLSGWTASKDIILKVADILTVKGGTGAVIEYHGPGVETMACTGMGTVTNMGAEIGATTSVFPFTDSMADYLRATNRADIAEQAKQHAQLLRPDPGCEYDKLIEINLDELVPHVNGPFTPDLASPIDKLGNNAKKNGWPLDVKVGLIGSCTNSSYEDMSRAASIARQASKHGVKLKSIFTVTPGSEQNIGGVVLANACGPCIGQWDRRDVKKGEKNTIVSSYNRNFTGRNDANPATHAFVTSPELTIALALAGTLDFDPRKDSLTGADGTKFKLDEPKGECLPANGFDPGEDLYQPASFQGDVVVDPSSDRLQLLDPFDAWDGKDLTDMVVLIKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFLTAKNAENDELNKVRNQLNGEWGPVSETARFYKSKAQKWVAVGDDNYGEGSSREHAALEPRHLGGLAIIVKSFARIHETNLKKQGLLPLTFANASDYDKVRPDDRVSLLGLGGLAPGKPVKCVLKHKDGSADEVELQHTLNEGQIEWFKAGSALNRMKQLKAASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWF3</accession>
    <name>A0A914GWF3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWF3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11806.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11806.t1"/>
        <property type="gene ID" value="Gr19_v10_g11806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002165">
        <property type="entry name" value="Disorganized muscle protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="106"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="208"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11806.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35615" checksum="89C92CA996BB5F44" modified="2023-02-22" version="1">MPDGKAPHFPQQPVARQNEDGSLELECFLEANPVPDIKWFYENNELKPTERFSFRLDNRGSEAYSAILQIKDLADSDAGAYRCAIVNPFGKGNANFNLKLTGFSSPTFIEKPQISSRDDGRVMIMEFKAKSILKPTFVWQKGDEIVAESDRYKIILKETGNHEYYAALEIVEPKKEKDAGQFVCTAKNESGKLTATFSVKFEVPQGAPTFTRKPQILQKTSDSGDPAIVFDIGFQADQNPEVIWLNAKGKKMKESSRIKFGLTPDGGANTYTAQLELKNYKAKDSGTYTCNIKNDAGEANVELTLNIEGPLDDAGDDESQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWU6</accession>
    <name>A0A914GWU6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWU6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11136.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11136.t2"/>
        <property type="gene ID" value="Gr19_v10_g11136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF60">
        <property type="entry name" value="CUTICLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037195959" evidence="2">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11136.t2"/>
        </source>
    </evidence>
    <sequence length="194" mass="21870" checksum="0957B69E354294A8" modified="2023-02-22" version="1">MLLTIITSSTLLIVIYVRWTNAQSSGNALQIREVTGRARQPEARCAFSVHETGPEGPEIRDVTLDQELFYKIRCEAERGYCLRVSNCTVRAEDGSGQRGGGSASYPIIDGRGCTTEPSLFEHVQYEDYFTAGIFNPYPIRFRSKSTGVRFQCITSLMMLEKDGQCPRESCTWEGGPKMNKAVRRKVSRKLERVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXU7</accession>
    <name>A0A914GXU7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12190.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12190.t1"/>
        <property type="gene ID" value="Gr19_v10_g12190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12190.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10589" checksum="80B8D5014A4220CF" modified="2023-02-22" version="1">MRPSTPISATTARIQPDKLKLEFGDQGVPLGLIAAIPLILQAKEITYAKQAVFSFAYWLFSMNLLWALIVDSIYFRRIGRRKSWMVCVGQTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXY8</accession>
    <name>A0A914GXY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12176.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12176.t1"/>
        <property type="gene ID" value="Gr19_v10_g12176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12176.t1"/>
        </source>
    </evidence>
    <sequence length="762" mass="83028" checksum="FBEB88BA2DA98C00" modified="2023-02-22" version="1">MSKSPPSSSKRSGGRHANCRPLRPPLVIVQVFLERLSSPWESHFDTTNAVQIRFFPFSSSSDTAAAAADGHLSVGNGRLFIMRQDQIGWLQLDIGRADGEGANGGWRGRLKLVEEGTQTTEAATAPMCRRIACELRSIEHGREDGAALPLMLSSSSLTAHLLVSVDEVRKRREERGGHVAEQKKEEGGDQRKRAEDGWAQTEGEEAAADGTSRRQEIGVQTVKEAQATEATATAEEKQRGQRWRRATAARVMMLMMAALNGSAQAAAAAKGNNDGRRRTMAMMIGGRRGREVIGATTTTTIGRPTKERETMTRVSIPPNANSPIRPHPNQSVLISQYRAQIAYLSAVHRTLVPQTAGNERKRRKKTLGGRRERKTEDDDGIRAEGWRGKEEQQPEERMGRTRTDVEEGWMKSVKWWEGGRERMNGRDDDEEGSSILQSVAISESDGSVAADERTMRGTAPEGMNGRMMATDYERDIRRTAPEGMNARMMATERDIRRTAPEGMNGRMMATERHIRRTAPEGMNARIMAGLGAIRRTAPEEMNGRIIPDEVTKRVTPEGMNGRIVPDKGTKGGTTPKRVTPEGMNGRIIANERDITRTAPEGMNGRAKSRSASKGTSASSSASSDSSSAPTRKKSIASSSSSSSSSKRSSSSSVSCSSTPTASSPSTKGSSDYQQQQKLAESPTNSSTLKGSSAKTESSIATDISKSRPKGSPSTIHQQRIGAAHILHKPCATTFFQQIFCHRLQRRRPIATNSSATCTLKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ76</accession>
    <name>A0A914GZ76_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Odorant receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ76"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12545.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12545.t2"/>
        <property type="gene ID" value="Gr19_v10_g12545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12545.t2"/>
        </source>
    </evidence>
    <sequence length="292" mass="33907" checksum="18A88D099384AFC4" modified="2023-02-22" version="1">MELFLLRHAVYERLYNCTGLDIDSIPMERRQFVPESIAICVLCAIYYLLYVPCMYSLWQHLRDNSCYKLLFYIGITDLGILWILGFYSGWANLRGAVFCSYPTLMFFMGMAVTALWVAESSADLVLAFNRCIDLVSPRFSHILFCGQRTLLWITGCSLYALFWALFIKPVVYSSIYFGWFFYPFVGYRTGDDQPETFSQVFFVSLINTLTGSLYVYIQNNEVHQWMITFAEFAWLHVHGMPPVIYLALNKTIREDCRLMFIKLFHRHRIGHIGGVTVIRPKINPLNGASPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZA7</accession>
    <name>A0A914GZA7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZA7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11779.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11779.t1"/>
        <property type="gene ID" value="Gr19_v10_g11779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11779.t1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43539" checksum="3A78AE5E72ABEA66" modified="2023-02-22" version="1">MTASTESSKRFVSSEEEMRQTHQVHEENVREMEQIRHTNATLDMAGADSFRAQTEQAAIKIVTPFYKLGEKPSAEVQLGSSVADLSARFARADSDYKAERSAEHFRLQIIEPKVISHAHIPAHATRDYARRHLITDFPSLHGKRSFIDLEAIEQRKLRQQRQLPEAGDRDRDLDKFLKVREEKEQWKTPWPAPKPDDESLRELDRLRHNIDQLQKASMRRSKSLDELRPVKAEQFPLPPPLPLRRTILEPKKDPPDQHNRRWRSRSAGRHRRRRCRTTRERGWRESASSSSSETAETETDEESWCSADSDQHQTGGEKVKHALEAVCANHTRAAVSEDRISVAEKHRRPDNVDDNAAHFLPDSRKTLRHCAMIKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H081</accession>
    <name>A0A914H081_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H081"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1203.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1203.t1"/>
        <property type="gene ID" value="Gr19_v10_g1203"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1203.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35771" checksum="258E8A98A552ED85" modified="2023-02-22" version="1">MPTYFYFLPVFTYISAPPYISHLFLSNAVADTNCKALNTELPATNSELSFPQPYELLSAELWLLIFGNLERNDLDSCEHVCAWWHQMIRHNSKYLASRVIDYVIFSSKRTFSMILSSGNIIKVYRTEKYFTSRNMLKPIGDPSFMTVETYRRSQSKPKPSADGGAQLSLYFEELRAFTNEAWESDDRKSGILGGVDAIGLHYPHFYAKTFYKILTPPSAFFLKLNKLLRNLGHVNYWVFQTFTLTDAFVEQFMHCVEPKIITNDIRLIRVKRGKAHHRAVRFFFNVVLGNRQILEKLPNAANVMMLNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0G6</accession>
    <name>A0A914H0G6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0G6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12483.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12483.t1"/>
        <property type="gene ID" value="Gr19_v10_g12483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12483.t1"/>
        </source>
    </evidence>
    <sequence length="639" mass="70328" checksum="848B740A949E4450" modified="2023-02-22" version="1">MRSPPTTSPSSQHNHPRLELLGDFDDFITSDSSAESASDDLEEFKPPPGERTRRVSQLNRVVRPRRLAGLRNAVTSTFCQQQQLRRNSPRKKSLLPMGAASAHPELDEPKKSSTTGQTTAAKNASNTTTSKRSTAGIVRKSSSIGSSSSSQDSSSLLIGAANGPILNVPVSMLKRGEHFSTSQRRGQLRGVGRLLSLQMATTCCVFNDCSDTPRQSAIARSSTGSRRVGRARRSRGDSYTTTPKEISAADGDGAAKGRVERGQHQGPKRGGRRGGGRGGPRGERQQRIAGSALILDQSNHDRSEEQVHEQYSSSSAESSSEEEDNARVGRRFKTLPETSAKEEAELSSSSSSTTTDEEEGEEEKPERPRGNSLGMVSPPLVPLVQQRQQIPYYSPPLVASTPLFQSRRKKNPNSKFVMLTATNHQHPSGVLSPHFDYTNPFETSPNSNEFIDPYQRKMRDALITYRFLGYLRPLWGPFMLRNLHYMRCLRPPRENFNCHNAQLVFSDNAGGGGGIEPIMPSKFSSDGPSALLQHSSANGQHHQPQQLMDLSRTSSRISNKFPATIRPSFIRNNLFFGQKKAIVHCFHVSECNGRLSPMKLIPSATFEMKVNERIRNISIDLPDGMHLGVLDGDKAKLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0G9</accession>
    <name>A0A914H0G9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RILP-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0G9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12098.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12098.t1"/>
        <property type="gene ID" value="Gr19_v10_g12098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14445">
        <property type="entry name" value="RILP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF4">
        <property type="entry name" value="RILP-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RH1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="7">
        <location>
            <begin position="266"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="158"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12098.t1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47708" checksum="87022A3C4AFAF15F" modified="2023-02-22" version="1">MESPIYSSSPSRHITVIDVYDLAESINRDFEKLVERFGNEHFDSVVRKVISALETLEALAKYNDKESSELLDLQKTIERFEQEKQQRLRDKDNLERDFMDLEENYRQEIDELCKIVQKLRVENKSMRDQISTSPSTLFEDETDPNGQSAAAEEQIKALIDLRKITQTQKERIKELQKDLDSYCDEVETLRESIERLIRQNKELLRKNSSLQKQGRVLLLERAEILRRLQQAEEEILQLRKVLNETSRACRDLEMHMQKQGEEESSPPCFTLSELREVLQEKNLLKAKVLELEERIDQFRDSSSASGNTIELGGTETPTGNTSVVSVCPPNSLLSQPSNPDEGNPDSVQEFSKENSDECLVFGPINREPEEKLRPWKYERKDSGVRKFFRFFKVNLGTSLTPRESSDAKLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1D9</accession>
    <name>A0A914H1D9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1D9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13131.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13131.t1"/>
        <property type="gene ID" value="Gr19_v10_g13131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13131.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20776" checksum="B982AA4954C24E5B" modified="2023-02-22" version="1">MTAAASKVSRVLSMLERAKLVCWFEETNSYTQTARRYRNEFGMEPPKREQVIKWHDNFLKTGAIGKMKDEGKSASEKQIFHKKCPRRPQFHRQKKRRFDFEDGTLSRLSLPQNHSIALDCAACSDLSPSPARHSVGISPSGAVGPEDLSLLHFLLGCRKSGQCNGQNQNKQKAKVSFHWKICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H230</accession>
    <name>A0A914H230_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H230"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12959.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12959.t1"/>
        <property type="gene ID" value="Gr19_v10_g12959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12959.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17594" checksum="65E82E0F48D151AD" modified="2023-02-22" version="1">MGLKSRRSSASPSDNGTIECVVCGAPASAVHYMVWSCNGCKTFFRRAIMENRKYSSKPSKRPNAFRIDWCIRTDCRGIVAVINFILAPIRRIQLTEVEYVFLQTLLLFDTDCLLLSESTRRLRHLFAKMGANSMGSANRMAQLLLRISNIQTKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2B2</accession>
    <name>A0A914H2B2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2B2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13347.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13347.t1"/>
        <property type="gene ID" value="Gr19_v10_g13347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052448">
        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13347.t1"/>
        </source>
    </evidence>
    <sequence length="450" mass="51392" checksum="1EF210E503B0A3A7" modified="2023-02-22" version="1">MGMASFPSHRNYLFASNLLFLLPLLLFVILVASDELNPYKTLGIRRTASQKDIKDAFKKLAMQWHPDKNKSPDSEQRFMDINQAYKILLMYVRWPPPPRKKQSDITQFLLPFGSVLGTLFFIFLVGYLLNHMNATDQTKRRRQQHNRAEEANGTGGVDVKTGDQERELNEDQKSPLTEKERQQKLQARIWRVMSPMIRELRAETQFGLVRLLKPGCRSVIVLVDKDSKNNLLQQFARHVYCLRNNKTFSFGFLMVPKNLAWFRSLLELTLPDEQPQEGEDAESVSTAVTDTESSEEKPKISAEGEASTRKGKVGDGCGDAGKRVRDKLKEINPKHTLGTVLVICGWKLYFSICHPMHRPPSIRLRVALAELGGAEGKDEDGSDDELRGECIRTAPPKVGNEQKEHNQQKNDIRTANGLERVLNGFPMFLDRLLEGTVRRYYVPEWPDNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H377</accession>
    <name>A0A914H377_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H377"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13736.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13736.t2"/>
        <property type="gene ID" value="Gr19_v10_g13736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13736.t2"/>
        </source>
    </evidence>
    <sequence length="69" mass="7213" checksum="AB8D8C9E509D2F37" modified="2023-02-22" version="1">MTLHNHLGICYEQNAFATRSGTELAGTELAQDGVGSGRSWRDGVGWDGVGGTELAGTELVDGVGPFRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H482</accession>
    <name>A0A914H482_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H482"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13698.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13698.t1"/>
        <property type="gene ID" value="Gr19_v10_g13698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037815782" evidence="1">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13698.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35851" checksum="B892686ADE978094" modified="2023-02-22" version="1">MIKFLIFCVVILFCTTLTTSATNDDESVLKLETEAKQFAEHITHCQFTFGPLTFNSSEIQSPQKRWEKTRQVATSNMASCEVPVDYRISTPDAAAIQPNFSLFYVDNTTTVPKDFLTYLPENILAANDPGLSEEQLIIVLKKIFRSKMSTTLLLNGTEQTKRSLPFLKRELRLMKHRFYLFRLMSNFKAEPERTFDFMPGFIGYYKDVAKKMLDLYKDLDNQTLIDAVIYGEHLLDQINSQSSASLHGNLLGADGKEVIYFVIQSWDKSLPECADDSLAHVMIKNGNAMERTAPTCRPKWPITNNALYESEIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4I7</accession>
    <name>A0A914H4I7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4I7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13580.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13580.t1"/>
        <property type="gene ID" value="Gr19_v10_g13580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13580.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21109" checksum="DE04E6D48A555D4A" modified="2023-02-22" version="1">MLLQAHDVRKKDIERAAHGDRPCRQSSIDFVSAVTPTVFEPPLGLYNFRKISSGHFNGVRFVPSSAELLPEIFEGGLDQRYRLESYHRHCGMRMRRSEHCIVDDYAAKLLPRVDHRGRALRFVIFPLSGFTDDISLQRELTWTVLTDPILITKEQLDWLAVNGQRARQVQDICARKIEFCSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5C3</accession>
    <name>A0A914H5C3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5C3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13969.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13969.t1"/>
        <property type="gene ID" value="Gr19_v10_g13969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13969.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15330" checksum="A735E1C152E8D372" modified="2023-02-22" version="1">MSISTESVNGDITADQEHFSSFDLVAQNGNDAVYTLYGQNDEIKLNNDKEFTADQEEEGQTKLDQLEGLEQKQTANAEQQKVDQKALSAAIDQGMNQLKEELSTDGARNVDHFSRMQTVECQQGCRIGEVSEQTATEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5I3</accession>
    <name>A0A914H5I3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5I3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13861.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13861.t1"/>
        <property type="gene ID" value="Gr19_v10_g13861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944:SF4">
        <property type="entry name" value="CPG4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944">
        <property type="entry name" value="PROTEIN CBG02791-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13861.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34584" checksum="DFA361D098A3BF6B" modified="2023-02-22" version="1">MSLTTSHSVLLLSPVFQLINHLFLITILFPLVVVISVSVLENEHNCDGNCIQEMERLIEATPSSTGIGVSPFLYSAEHNFMSQFFSRVCDAYRGVDECMVRCESRSKQVSDLKAAYSGLQFVCKEQREEFFGSLPCLSENESKGVQRCSAQINQSHITTVLFTNSIISREFHSMQLRFSSLCRDLATVVRCMIPVIKESCGEQPANLLLKFIGLEFSSFELLYRQLGFDAPLPASCRALITFALANDRAQKPKTRVLLTKLHNNFYLDDHQNNLNGFPSFSDQWKLINQIIFVVVLHSIRIHYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5L9</accession>
    <name>A0A914H5L9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5L9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14214.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14214.t1"/>
        <property type="gene ID" value="Gr19_v10_g14214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037825652" evidence="1">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14214.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11161" checksum="85B07B572B0C2F11" modified="2023-02-22" version="1">MVIVFILMISSATLEAQQNDKFYDLMTTIGEFFGGEFNGTEKALELDLNGTNSFLKELHTFATHKIEGQRMRCPRMTNSTTMYHDYDKQYDYDVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6F7</accession>
    <name>A0A914H6F7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6F7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14612.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14612.t1"/>
        <property type="gene ID" value="Gr19_v10_g14612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14612.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="44813" checksum="7FB7536A065E4ABE" modified="2023-02-22" version="1">MSDKRTGDIPYFRTVPSSPSDDGGLADEGEEIESMSPIIVQPQKVQAVEEDEETMLRRRLLEKKLEKERGKTSSKVGNLKERDEAKGTAAGTVERERTKATEKEQKERPKREKIVWDKQKESKSRYGQTDKYGQTSRIQPSSSSSSSSSHHRRRDETSSAHVHEHRHQRRDERATSSRDHHRHRMPDVGADNERTRTTPAIAADEAEEKRQKKRLRNASDGGTSSSTSSKRKQLDDTAAGDDDGTLGRKAKSEVVLIGLLTEEEQEVDDELLVVEAVQEVEVVEIQAVTGPTGAAAPAQLQQQEQMLVEEAEEMGTGGGGDSGSNRKKSSKKFSKFESSPEDDDGSVNDDDDDDNDDGGAQMREEKTDVAGEQYQQQSSVKDVGGGSGSSKFNDDELFMEEGVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6G3</accession>
    <name>A0A914H6G3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914H6G3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14447.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14447.t1"/>
        <property type="gene ID" value="Gr19_v10_g14447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1770.10">
        <property type="entry name" value="TPR 1 domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="12">
        <location>
            <begin position="73"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14447.t1"/>
        </source>
    </evidence>
    <sequence length="964" mass="109389" checksum="E5E77C2D375C0798" modified="2023-02-22" version="1">MMDDQCAERIEHVAVDVDSEDQEGAQMDAQQQQAATGQQKCMTNKRLGAALRGDRVTLRDKYQKSPSSNALRRSKTIATTYMAASGLTGSSTGNSHVVAVVNFALALFGGPEELNENSSGNFNLHIGRDVGPVVVGVIGTEKPHYDIWGNMVTDETKQILEREGFHSSAMAKSPSRQRTDDHLFAEAAEGRGAAARRRRSSAIPSMNQQSHGQWADGRRGEISDPIIIPPRPRDQNTPDVILDELVKLEQSYRELNLFEQEASFIVTTYCIPEGHITLKLSMASAKIFLKAIEDVRKESGAKDLGRISAPKGKYSLFYALELSRNYQLINKEITENKFRYLTKTANKQLDLAFELMEKTGIDGSARAYGVEHLEGVQSFWDKEYPDMFRIVAFDTKRGLKPIFKGDAVKKYEVCVVLDNGHWDGVKSVSRPERHRIECRERCKNCCRMGFGYPCKKESGTDLHCDICNKDFYNEGCFEEHKKKACRIYHKCRKCGEAFRTDRKHVCGEKLPKYRIVAYDMETATSEEREHIPNLISAAHTCTDCCEEKNKECDICVPGPRLITWSAADGIDPLSEFIDWILGFKNADTIAFAQYGGRYDSHFVLTGLAEKGYAPEVSMADLKIYQIQMGKLYIRDFWMLSQNKLADLPKTLELGIPAKLYFPHKYNKNENFGKKLPQLPPFDDYGPGTMTEEGYGKFAVWYEENKNTEFELGQQLKVYCENDVEILMAGILKDAYSGGRTMPFCLYAEASENVEIAMFDIISLYPSVNYDTPYPVGIPKIVKRDEDVLWTEPEDVPYDGLLKVKVISPKTLMYPLLPVHVGGRLLFPLCGTCGKKEKKEFVLAKDEKKCAHNEEERALLGTFTSIELRKALELGYKVTHFYRAYHFEEFDNQLFKGYVRMFLKIKVEASGWPPEVNSEEEKKKFMEMPKKDGRVISQDVPKNYEPVQQKGIIDSNLNVLPFGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6K1</accession>
    <name>A0A914H6K1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6K1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14159.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14159.t1"/>
        <property type="gene ID" value="Gr19_v10_g14159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14159.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27656" checksum="0F3C0128AC0F4E37" modified="2023-02-22" version="1">MLCKYAQIAKSRCYKMNLNKKWLPIICIISCLLLETLAKTPFNQETNDELEEKKPSVKHSSKLHTNQSSKSKSTKVPELAERQAIYKAFCGNRQKHSTGKAACCATMREQAQNRNEDKLSIKNARKLADACKPYRKALFKLSKAYCNHTHKIYDKNGASGNGKSANDNSENSRKAKKRKNVDSNSSPAMGDALHKSKAAGSAQNNDENKKDKLGQLVDEGYEIKGFSQAHEANKPDDTFVWTLVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6P2</accession>
    <name>A0A914H6P2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H6P2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14511.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14511.t1"/>
        <property type="gene ID" value="Gr19_v10_g14511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14511.t1"/>
        </source>
    </evidence>
    <sequence length="571" mass="62882" checksum="29A23650860C8C16" modified="2023-02-22" version="1">MMVTAPSTNGSNSVVVVGGGGAAKLLTCLICGQSEPRNIFMAHIAEHFNYQPHKCAECDFRSVTAEQMADHEAATEHVGQLYALRNAYLDRMCRFVYNDCDFGEKNGGLDKVLKRKLVSTVEEEHASTGQIIRQAVGTMMKAEECGALASINSKMHSAIVSATVGDHRAGQAVQQWLLQQPQQHQFDTEQQQQQQFYVQSSSSNQTRGGDELKLEQLLMGSAGTAGAAQLFQQHTDQNNFLGDDIAAADEHQQPQQENDAKLVPSSSSANACSSMLQQFIAQQPQQQALLPQHFDGVVEQYIHGQQAPPPSQLTNGDDVLLQPTKTKSNKNCKQVFENVQCLKCRQWVKGRGICLLYHMNTRHLKLPLYRCLACPRDFFYVTDTTAKNHIRSFHGNDLTLLENNYHTYSGLLHGSRREFFGTALRGSEARTQRATRKERAAAAARGAVAAAATLKGRASGGVPKQISLRDRPQSGSGPGGSSSHVQCLQCGEFVASIYSSQLTHMNTKHLHMAVYTCRLCGRAFESMSSSAAIMHVKSAHGRGRNEAEGEIAEQRDVCLKELNERYRSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6Q9</accession>
    <name>A0A914H6Q9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6Q9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14701.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14701.t1"/>
        <property type="gene ID" value="Gr19_v10_g14701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14701.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7202" checksum="4262B84CD2917AFD" modified="2023-02-22" version="1">MMTVFPACCATTTCGNTSATPRTAPFAAKTPLMAKPSGRGPQRYRTVLTLWPRCFFRTCVPSDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9Y9</accession>
    <name>A0A914H9Y9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9Y9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14626.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14626.t1"/>
        <property type="gene ID" value="Gr19_v10_g14626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14626.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28918" checksum="BBA971907E46D7DE" modified="2023-02-22" version="1">MFDKNGSISLNEVVDHLGSKLDNGTAAATNVAKNVSWFAEFDRSGNNQIEPEGFDRLLIGGKSEYSLKAIEMVSKVFKLFILNAIVRFSLAENETLCFAGIQYNDNQYNDKELPLYFDVIFEKSGKFKKMLNNQTLETCDDNVLECVTKYCTEDDGYDVFRINGCGIANGTTDDRHPTDECSKYSAFDEMCDTKNGQILKCNHTTGTKSNSARLKLNVKPGNCTTRPNRLKSCADAVPLSVTLSFMLLLLLLLGVLSIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA51</accession>
    <name>A0A914HA51_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HA51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15459.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15459.t1"/>
        <property type="gene ID" value="Gr19_v10_g15459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF523">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15459.t1"/>
        </source>
    </evidence>
    <sequence length="626" mass="69345" checksum="2D8AE1772028E960" modified="2023-02-22" version="1">MPSREQNMMGGWGATAFVVNGIIGSGIFITPTSILNNVQSVGASLIVWLLAGIISVIGAFCYVELGTSIRKSGGDFAYLCHMQWTTVAFTFMSAANLFIVPCYLAIEMETFANYLQRGLRAHFCEPVHLCLLFGKLSIMPREENMMASWGATSHIVGNIIGSGIHYANQHFEQCLIWIIAAPIAATLGAFCYVELDTSIRKTGGDLPICATILNLFLFLFCSNLENRTGTEKEQNRSANYVVNRLISFSCIILLFFLNCFSIRGVVARFQMLAMIAKIIASGIIIIVGLMVLVTKGAQSDNFREPFANTSTYPGQWVLALFAGLFSYDGWDILNFGAEDVKKSHRSMPFAIIVGMSTVVTLYLAMNLSYFVVLSVPEVQKSNAIAMTFAERTLGGFLQYAMPFLVCIVLIGSLNATLFQGSRYIWASARERHFPSFISCINRQHDSPRAALFVHVLLSMAFSFLGNLEELISYVAFTIWIIRSCTMMTLLCIKLKIGAHTRRQGVHEKAIRVPLVLPVLFLFICLALVFVTIVQSFWASAVGLLILGIGLAVYVTFIWPHAIQRFGWYRRLSHSLNHTTCIMAQIAFNGNIELIGQGDQQNAERNVVNVPPPSTAHNAKSRVQPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAC5</accession>
    <name>A0A914HAC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14736.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14736.t2"/>
        <property type="gene ID" value="Gr19_v10_g14736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036882601" evidence="1">
        <location>
            <begin position="25"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14736.t2"/>
        </source>
    </evidence>
    <sequence length="509" mass="58264" checksum="99D9FA63883A4099" modified="2023-02-22" version="1">MHQILLLTIILMLFLLLITTVVSAVTVEVIEDGTPEGQDMAKALALSKRFFWRNMMANWSHYIDYEAFSNHEQIGEISREESRQLIFLKDLRQALATDAYVKCWECKQTNADDEAGSSSLTNQLKKDQFKCLCVKPKFLVEQGELQLSSAMEAIKSVYRDLFRWGSGFLSFEINFVNQKAWYLVHHWQLSYANWGSKLAENILLKVKEQLVGDDDTISLSKSILASMNELKYEETMPNGEKRDYLKELNAILKQAEMFSDLPKKIKKGKAEHVDLNAVVKVYQNYWELVQEFGLGMAAMCEGATKVEKIYDNTMHKFVEIFKAFGRVFQELSGTLLWRLRRMVHDMMLQMNHGNELKPLLPDPCEEAKFKVGLLDFECRALIRTLGGTIFNKSNGMHLDIVLLLLMLALCVACNGMPRSNDSTKIQKHNRAPEAMFQRVAPLTHQAQQVQRGQQRVNNGFNDVINGFNEVNNGFNDFISEVLVTNWGIRNQGKGCDEGWVTCKKRILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAJ7</accession>
    <name>A0A914HAJ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAJ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15739.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15739.t1"/>
        <property type="gene ID" value="Gr19_v10_g15739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15739.t1"/>
        </source>
    </evidence>
    <sequence length="454" mass="49838" checksum="E7FECDCE8BD5BC92" modified="2023-02-22" version="1">MQIKHKICETHSDSLKSANVHLDRDVLHDGDGAGRRRMCILGGGGYLGQLLALSLQREGHFVVLFDLHFPSFGHICVDSRSCLKITGSITDATELRKALAGCDACFHLAGYGMSGGPSLDREKCFLVNVEGTRRVLEECRRAGIGRVVFTSTVLVIFDGSELDMADEEGTPYIRTFGSNAYAESKCVAEKMVLMANSQCLATCALRLRGIYGPGELRTVKRTADLCMRGVVKCSFGKTPRVLTQYSGADNTVQALMLSEKSLREGSNSRAAGKAYHIMDGGPPVDSFRFWYPLIAGIGCPLPSIRISYNFAYALGVMFELVYKMVGWEPLFTRHEVALMGVPNTYSIERARHDLAYSPTPASDQLARTIEFLRLQLDADRETASSSGSYSAKNGGSGGQWLRDRKWLFLAYFVDEAEKALFPSKWSLVLTALLGIFIAMAFLISALPANRPDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAZ9</accession>
    <name>A0A914HAZ9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">XPA-binding protein 1 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CLEC16A/gop-1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAZ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15858.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15858.t1"/>
        <property type="gene ID" value="Gr19_v10_g15858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000888">
        <property type="entry name" value="GPN-loop GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="15">
        <location>
            <begin position="48"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="16">
        <location>
            <begin position="242"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="16">
        <location>
            <begin position="359"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15858.t1"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125233" checksum="09DF7A042A540742" modified="2023-02-22" version="1">MLKKITGNSSLWKPRNPHSLEYLRYLHGTLMKNDKITEANSALVVEALRAITEVLIWGDQNDGTVFDFFLECQMFSHFLRIMRQSSAAAYINIQLLQTLNILFENIRNETSLYFLLSNNNVNLIIMHNFDFNNEEIIAYYISFLKTLSFKLNPKTVNFFFSENTNEFPLFTASIRFYSHSESMVRIAVRTVTLNIFKITDDLLEKYVLSNSQKYFDKVCMKVATQIVDMDIFARSAQNEQSNRSRLMTMMDMHLDNIHYLNDILMTDNEHLNTLLIESIYRHIFGPIYLASLTGVRAQPHTILVSRVASLFLVSQFFYVVHVEMAVRTLLTSLFFGDQNDISTEWTRTIEGKLQLSSVGKWENLQERIFFHCHMNSLNEGQDDHSCFYALLLIYCICQNRGVQNELLLASQLPYCDGFTAKCDPELTESLIRIIENCSLIDTPIRPITIQLCCVIFRRILVSLESDQHLHSIVELAVRRSQHKLQNVLRGALQTEKFFLEMFEDEYWHLQKSELKMKELLGDPALFLPPSNTPLSGVTLTKRMPSGNDEHIRRTLQFFFVLRKFEQDLCGQHEEVLPLSSRVQEVVEINDCINLSNSDLLACTVVDEKNGRLSRFLVTDQFQLILVEPDSRRLGWAIVRFVCQLQDVQVSPTDNRTLHVVVEDVKMRFQQAAKPSFDAKLVFDDHIRCMAAKQRLSRGKRSSRAFKLSLVAELFGMRPQQQQVEGVSRHSLPCHSATASLSMEEKRPRGATPGSVQQLRVLALNDSSDASIPPDPESDTFFKNKSRMAEENLASSSTNDSLPPCLIVLGMAGSGKSSFVQRLSSHLHAKKVIPYLVNLDPATGTVPFPANIDIRDTVKYKSVMQEYGLGPNGAILTCLNLFCTRFNQVLDLLDKRKSFIPYAIFDTPGQIEVFTWSASGTVITDSLASVYPTMVAYVMDSARSTNPTTFMSNMLYACSILYRTKLPFFVVLNKADVADPTYAVEWMRDFEKFQSALDENASSFMNDLTRSLSLVLDSFYENLNWVSASAKTGQGFDEVLKVIEKCRMEYWTVYKPMCEQVARERTAESEEDKIVGTLTAEKLAKMEIREVDGNGHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCL6</accession>
    <name>A0A914HCL6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g16277.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16277.t2"/>
        <property type="gene ID" value="Gr19_v10_g16277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000022">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8 10" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="982"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1128"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1209"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1325"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1352"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1389"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1437"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="12">
        <location>
            <begin position="266"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="1493"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1707"/>
            <end position="1750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16277.t2"/>
        </source>
    </evidence>
    <sequence length="2034" mass="226310" checksum="E17A7D73B0989440" modified="2023-02-22" version="1">MPSGELANRFGLLGAFIGKYAVPSVLISLALLAPSLIAAFFRIKLEVGLDEGFVPENAPSRREIVVQKAFFGETNRSKEWYMALFGIARSPEGNMLQIVINGPRGNFTYAQICHPLCEINDQIQKLMDIAWLKLLGQVEMQYPVSRVLSYDVNIGKHVFNRTVDSKGELVGAQYIAFYFTSFSRELLREKELELFEQAVEREAARHNAQKDKRVELVAHGSNAVSSEMTRGVLDAGRNKLVGLNLFGLAYLALHSLAGWLCDQVPGRRFLLALLSLCMPALSLLASVGIVSIIGLPVSLVFFTSPLLLLSVLLIANGTFHFTSAWCRLLNESRRKHFTASERLASTFDQIAPSFLCTHLPPLLSFAMLFFLLPAKHYRILAAFLALLHLNSIILQVFLFAPLLALLCHHQSVHFRLENGNLEPPSLDLGTTNAEVKKPPTTGHPPFAKPESNTSKEAIQNPVMNGLGTEKGRRQNAKRCFHCLLSFPLDPLGVFLSSLPGKCLVLAASTLLLWLSLARGVPLAANGMDYRRLLPRDSPALRGFNLMDNIWMDFLQILYIIRRPPNFEDPKQYVKFKEFLSEATSMPQAIAPRAHQSWLFDYHRDQLGSDIFAQLSTAELFADSVNMTKFSAFINGFPYRAWRSGVHFTLNESKLSPSIDQMIVLIAYNGTRGLTGKRGLINQCRTVAKRFPDFLISVFDTDSRTVDIMDTIDPFIWRSVFALVGSAFVVPLLVFRNFCWALLYALCTGSIFINLFGLGHFLGLQFDLLTAPSAIIIGVLSAQLGGHFLDCGHGRSALASGRSASSASVPSAVLRPPGSTVLPRRRFECVALCLSPPGIGFFCPPTMDFREKTKQQMINSTPLNGILKKTDRQYSYENTVLGRYRLEASDGTEECRQRVGFYEDALLTDEDRIGQLNVATLRRKSVRFRDSEGAQREVEGHGEQQQRKEGAAWRAPRPKEWMARTRKWAKSLRNAFSCKSIRLMLIDWLFLAILGIGMAMTSMFMDNIIEYLQTFQLVLMSVSGETGNSFLDYICTYLSWLCYTELLAVGSGIPEMKTILRGVILKDYLTARTLFSKIVGLTFSLGSGIPIGKMGPFVHVAANAANLLSSLAARFDGAYSNECRKSEMLAAACATGVACTFSAPIGGVLFSIEVTTMYFSVRNYWRGFFAAACGATVFRWLRVVAFGTEVTLVAFYQTHFPEDAFEPEELPFFALIGLFCGFIGAGFIFFYRKVVMFLRQNSFAKRNIQNNWLLYPVVVAFLVATFTYPRGYGRFLSGRYKFTRTVLDFFSNCTWSKGLHHSILAPHGCSSELLGTWTNHEGYGPYNVFLVLTLFIVTFLILSALCNTMPIPCGMFMPLFVVGAAFGRLMGEIVSSMFPDGISNGTDQPIFPGIYAVVGAAALTGAVTHSVSVIRATFFSLKSPFSVAMICCEITGQLIYIIPLMIAVIIANAICAYLQPSIYDVMIGIKNLPYLPDIPPSNAEVHQCTAENIMVSKVRYLCRLTPFKELRSLLVEMPKLRSFPVVDDSASMMLLGSISRRTIIELLKTQIGDEARKREAEKRIKKAIETIDRHFREVQLDMLQGSVRSVHGEAKSDLDPKDAKGQEIRRRAKSEGGVRAMPAEGTKTIGRRCSASDTNIDKAGDSERKGEDLDACRTVGKKCSSSMHRVFPAAMRWDRNGGEGQSSRFVVEPVFSLPKRRCVSNAVGPMAGATRNRRNAISSSSATEMKEEGTEPRGATNEEGGKENGEQLITQKKTSCPEMIRSNWGTLEHQTPISRNLAEYVRSAKKRLRMVNLRHRENGESVDYDLTDDERREWELAQLGHPLEIEEKLIDPAPFQLVRRTSVYKVHYLFSLLDLERAYVTERGRLVGVVALRDLRIAIQNAQNGHSIRFNLYESDSTTGSDKSLDESLSMDVEKGTASVNVADTETGQRQQGQAVPPADGMRIDDSASVITVADYPISSPLQRIRKDENEKRNWGRSQSIRSRYLSLGDHSEEVGDDGSGNVARAVAYLRRKSVALERTPLPMVEGESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE38</accession>
    <name>A0A914HE38_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE38"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16509.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16509.t1"/>
        <property type="gene ID" value="Gr19_v10_g16509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16509.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8668" checksum="17428CCDC22194E7" modified="2023-02-22" version="1">MDDFVLNFKKAQTFIERLKERVETALNAKDEEIVQLRDELKRVDNELKRCRTENEALTKKIWQMEKRNQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE66</accession>
    <name>A0A914HE66_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HE66"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16686.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16686.t1"/>
        <property type="gene ID" value="Gr19_v10_g16686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="73"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16686.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41848" checksum="14D5ABE2FEAB8E4B" modified="2023-02-22" version="1">MLCATRRSNSKAALLDAGMEEVVMFEQYKRNEFLRNIFHFFRVHLPPSNSFTETRRLCALRAFVCVWLLPMSSASAVLMRQLAELQANPPDGFAVRGIVNDNIFKWRLVVFGPIDTPYEGGTFLAQLDFPRSYPQRPPKMRFLSDVLHPNIFKDGLVCISILHEQGDDPFGEEKASERWQPTLTVESIVISVQSMLSTPNFQSPANLDAALMFRTDILGYNDTVRQCVRQSNEMFEAEEQRHTNNHYEGRGLVEVRYINHDDDWHVVEHRPNDLFGILPEEHRQNNNDGGDERAIEAEEQRPNLANFVGLMWPVYEPRQNNNDDGAGRAIEAEENRHNEEEDYVMGPGVGQHRQNNDDDEEDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEN2</accession>
    <name>A0A914HEN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16440.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16440.t1"/>
        <property type="gene ID" value="Gr19_v10_g16440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16440.t1"/>
        </source>
    </evidence>
    <sequence length="643" mass="72359" checksum="AB50FAD9587F6C58" modified="2023-02-22" version="1">MTQYYGRIGRLIGFNPVRRAEVEEIMMDESAREMAEASVQYIGRGNRRLKDVLLGNGGSSTNASLHFVLLYSESRTSHPVGFGVLSSQHTEERFYRQCLGQLYQMAGRGKSCIFVDLDVLLSDDAATACDGLPQGILALDGFPNIGSRLTKMRGHKLLTADCVTEEAEKLQICIARIENSQRTQVGAVPPKKTEPCSLPCPLCKGYGGKCQNTDLLWCCDDCGQTLAFVKEENAPITHFYCACGATPVEEFSFRCNDVDAHGNEFKHFASNIALDVDDGDVLMSEEQQNANREGGRCLEDEDVPMGEQHNSDNDLEPIDRFLLSGKGHLGNLYNLHSDNFVTFMRKKFNTRSPTEQMALKPYNDSIEEFLLLSIQDAERLVVKSDREADRKLQMEQLKGLEELLSLYNDRKKLINTINASNSAGPKVIKAEDVTECFEELYKLPIFGPIIKQMYEVQQKSREDNAKEYKEEEAGTGFMPKPSRNGMRRIPVVGSVYTFVRPSPAQPPQQLQQQKFESFSSFGIGESRFSNNRFNGRTPSNDNQNQSRFGHRLMEQSVNILWQVPQLFVMTVGEILLSVTGLEFSYSQAAPSMKIFFGNIIDIIISHVQISDPVEEFFVYAALMFAVIGLFVLLSMRYKYVDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HET5</accession>
    <name>A0A914HET5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g16483.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16483.t1"/>
        <property type="gene ID" value="Gr19_v10_g16483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000006">
        <property type="entry name" value="Double oxidase: two peroxidase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF133">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036722056" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="871"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="1273"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16483.t1"/>
        </source>
    </evidence>
    <sequence length="1604" mass="179592" checksum="25317651BABFDEBC" modified="2023-02-22" version="1">MIKLFGPLLVCLLGMVGILCQHFSTDDWVPVRPERVREAPDDAGARVVKEMEYALNEVNLLFNRTEEALQQQFAAHPGAVIDPLAQARALWAVHTQPLWRARERAFGAMAALAATKRFKKARMLEQPAALAHANRALRRICASARDAQMNCDAVAYRRVDGRCNNVREPQWGAQFSPFGRFLPADYGDGVAEPRRSSAPSHSSDDRGASLPNARLLSNLLFREPRPQALGPSGVSAMAAHWAALIHADLAHIGSTQMMAPDFPHASQPLPCCAMEHLLVPPGGGRPGHPECFPISVSGDDPRFRGMVTCLDYARTMVAPRSPNCSLGTREQANQATSFLDASFIYGSSSDQSYRLRALRDGKLMVTRENGHNAGETRRELPPTMETIGGPQAAQPPKCASRGLGACFVSGSEQVNFLPSLTALHTLFIRQHNRVATQLMALNRDWSDEQLFQTTRRIVIAQLQHITYEEWLPLVLGRERWVRSGLGGQERRQKGSHAEASANANDFELDLDGSALNEYASAVGLFFMTMLEGKFAHLSPEGIRSMDRPLGEWMYEPSPLMFSDRIDGIFRFMLRQPALMPGLHMSAELRDKLFRQNGPHGLDMAALIVQMGRDHGLPGYTRVREACGETAVNSFDDLVDIVVEPKRIVPIFARHFRHVHDVDLFLLGLAERPQKGALVGPTFACLLTAQFQTTMRGDRFWHSHRMDPWAFTEQQLAELRKTSLAQLICANTDVRQVQPRAFESSDDYDNFPVHCDNSSLMAGPDWRAWKDAESHIQMPFSMRTVRKAIVSFLPIFELGLERMLERRKRESQNIAKNQGIVRSGDVLFTYAQMMRPKREAIRVGRMSQVLLEATKLLMAGDARLLLEGHDNRVDAEDDGAGGDGPPPPVENQPPLHRMDAQTLQRVLAQFDISGILGNIEPFVNSIEHSGSVEECLPRDQPCDHTTPYRSPNGWCNNLRFPHYGSSFSPLRHLLPPVYDDGVDAPRSRAKNGHPLPSARLISNALHVDQPFEHSKFTHMVMQFGQILDHEVTHSPVERGPNDEVLNCTRCDSPKTLSEHCMPLPVPEGDPFFPKFDHNGEPRCLPFARSVLGQLTLGYRNQLNQLTSFIDGSAIYGSTQCEAAALRAFEGGRLNSTNLGPVNTEALPQGDQEQDCRGKPRFPCFVAGDERNSHQPGLTTIHNMFLREHNRIARQLQAMNTGWNDEKLYQETRRIVGALFQHIVFKEYLPKLIGQREVDRHDLAPLSSGYFARYDPTCDASISHPFATAAFRFGHTLIRQMFPRLNPLNYANYTEPVDLVQNFNNMESLYDHKKGGIDTILMGLLGARAMAFDRHITDAVRNHLFGFRGQPLSGLDLIALNILRARDHGVQPYNSLREFCGLSRARTWVDLATEMDPATISALQSVYEHVDDVDLFPGLVSERPMNGALMPPTMACIIAEQFQRLKKCDRFYYENEGPETRFTSEQLEEIRKIRLGSLFCQNVKSLTKIQPDVFSVPDHLANSQIPCTQFPRMNLARWMERPVCSIGNAQVPRGATKLRSPCVKCTCTAEGPKCKAIRVLNCQNLLNNFLLADIREDMACVMQCASLLRNNAGTAAAKDENGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEV1</accession>
    <name>A0A914HEV1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase D polymerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEV1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15969.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15969.t2"/>
        <property type="gene ID" value="Gr19_v10_g15969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052171">
        <property type="entry name" value="NHEJ_LigD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42705">
        <property type="entry name" value="BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42705:SF2">
        <property type="entry name" value="BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21686">
        <property type="entry name" value="LigD_Prim-Pol"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D polymerase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="DNA ligase D polymerase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15969.t2"/>
        </source>
    </evidence>
    <sequence length="566" mass="63314" checksum="6D0ECAEC3DB6CE2A" modified="2023-02-22" version="1">MLYPELELTKKDLAVYYQNVANRMLPLVNDHLLSVVRCPDGRTEGRKGKRNKNHWAKVFLRVCHWACLFDCRDLEHPDRIVMDIDPGEGVTFDHVKSAAVELKERLQSNGLHSLPLLTGGKGVHVVAPLIPKANWDLVHKFTQEIAKQMEEDDPDKYISQSAKAKRKDRIFIDYLRNSRGATAIAPYSTRNQKGAPVAAPVTWDELEKAEGPGEYNVKNMLERVKETDPWQESQKILIIAIGMTSTSHQLLFSLLILFVSLPLVRSRYEDRYNLNMLPWDLRPVQDFIGLWQMDRSSGNFKELPAPNLIDLAINPIPKFGARTVNITHTYFDAGRNVIRSDYGFMPVKNATRRDPRVHVAYLTTSSEGWSMMEQGFFKDGKLILHLKQFLKRSFGAGGAGGNLDIREFERQFELSGFHSMTLKVRAETSFQTESYTAWKIVGNVPPKVLPMGVSGRTGWIIGWMIGCITPGCCCTYEGDEAVAVVQRALGRIVPTVKGEQGRGGGGDELGGGRGKGRKEEEKHKGRGERVGGDVRGGHLSIGMVLLMKLTPSEKSTAKSTEPTNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFY3</accession>
    <name>A0A914HFY3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16807.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16807.t1"/>
        <property type="gene ID" value="Gr19_v10_g16807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16807.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25797" checksum="141F53386A946CE3" modified="2023-02-22" version="1">MTSTERSIDAASKAGTSRQSATSQLKQHQAAPTTTTKRHMDGGSPRRKSSSSAGGGVQAEQREHRKWATTAASGKDQKQQQQQQQLKKDKKRPLKMIHEDNDDDVEDEDEDGEEGEAGPSGDAVGSGGTALSSSNQMRMLPQTKVRSIMEASPNVSGLKISGEAMFAMGKAAEAFISLLAKGAHQQMLECSHVRVNYNELALFVHHNEELNFIQDILPRKHKFSELNKLMLKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGW0</accession>
    <name>A0A914HGW0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b561 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGW0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16502.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16502.t1"/>
        <property type="gene ID" value="Gr19_v10_g16502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16502.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37838" checksum="CCF1C5780566C1FC" modified="2023-02-22" version="1">MLLRRLTKAFKEERTNHQTLEMTFLSPRANYCNKKEMPRSPVPLLFWCAILVPIGRSLLYDKNGSLLSMTVNPTEALPNETTFSPEAPQLQQVPRSTSSVPNDIVTWTEFRSILAIVGALIVLFLTALCVESEQNPELYRRLRYPSILCLGHIGIFALFGVAGRQSSWSTIGGSVILVLIVLLAVQIFCSPAEVLLLPKYEAIFYLHAFFGYVALLCVGIASYFGAACLNGYDWFIFGGAFLCFFELVAIFVHRPSSLRYPTDWKSPPCILPKIVALYGYVLIVYLGILGNLSLVGFDGKFAVLSAAVFVFFWLLILFYCGSISRSHWERFLRNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHN2</accession>
    <name>A0A914HHN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17452.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17452.t1"/>
        <property type="gene ID" value="Gr19_v10_g17452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17452.t1"/>
        </source>
    </evidence>
    <sequence length="545" mass="60558" checksum="2C7C2C3EE45CB74B" modified="2023-02-22" version="1">MLDFTNCWSAFVSLRWLRRFWRNKTPEGKDNRLTEGEEERRKGEKMVGGLKKTEERQTAAIASRDPKKGQRHYSLRRHNCASALDGTSNCVPSPISPHIEEATKGSGSKRKDDPPNASPTSAEGRLRPSSQSARPCSSLVDGFCPGRPFARIRLFVQYSQQKKLLIITLNELAQNVDDDLWSMDCSKESLQVRLALLSDCPTPKVQKFRSAFVPSDPFPLLAVQFGQTFAFDVPPGQLAESVVRLKLYRKSRQKRADCAGIAFLRNYLVDVEAKKAQNHFLQFCRILEPMGGPAKGSLSLFPSLLSLHPHHHHNQLQPQSSKCSPSPSPDLRLPPHCSPSPSTYQRTSLGPSFISPLYPSAIYNDGSSPTPSRRSSTVDESGRFCSLPHADGQKPEVLVSLCFFEDQNRLAIGVDKVALRGQAQRENGPETEVFVRITSISLQGTETEKHKSASVKMAPEMTLNTQTVFSLCQPAIDTTQILVQLFASQHGVFLRRKLRLIGSLALGGGRCSSSSDAREHWRQMLQGKGTTVDKWHILETEPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJC5</accession>
    <name>A0A914HJC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HJC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17165.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17165.t1"/>
        <property type="gene ID" value="Gr19_v10_g17165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="595"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17165.t1"/>
        </source>
    </evidence>
    <sequence length="891" mass="101785" checksum="0EC9F69987F0DFE2" modified="2023-02-22" version="1">MSQNNFQHPKQQQLLDEQCKYLFRMANEMKDDEQRFNFVHGHISAVEDGMREGDQKKKVVKSMASWALKEFNAKDVYKMDVRMLDFWKFLGKYSDDLKMEGVMENVHRLGHFKTQPAFYLLWAEHWASLGNRRNFDRTVTMCENNCSINPFECKELFKPLVCKYFGEPSEETSNTMALIKVLAERPDDVRRTLTMFPDRTTINLRTHNMVEVQPPKKPQEQQPLVASRDEFSIFRDPTTLVAPNEVAKQQKNSENAAAKQIQGAASTSTAAINPKNAVTIEERTEREQEKPVGSREGFSIYREPTITQQIEPETQKEVIVQPSFMSIQDDVELLDHVTGKEPQPLQSMLCGDVDDITLSGAHGKFAPTVFTSTPRRSVAFCAFDPLLMEMDDDGLMGPPTPSRKDRIGELFAPVSEVGGSKLQRRLSLAGDFPTHSEKLSTNQIAGPKKSANDISKAMPHLKIGSTIAEETEEEEKENSFISPYRKKQRQALTPPRPSSHAQIHPEPMPQQLPKNTSQPLEVLAQLPEKHFDPDGTHLGTVIEKIKTGTKNPWDEEKRKKVLRAAHVMVECHEFLNEKCPRIEVNRTTDLGGESFYVEKLLGQGGFARVYKAISRENCRAYAIKYEAPACPWEVYICSALKQRIPSKFVAYLMEVRDAYIFKNASAIVYDFYPRGTLLDLSNVYKKHGAEMSGLLVTFFGVQLARTLQEVHQVANIIHADVKPDNVILLTSSLNDCASLEELMNTPVLKLIDWGRSIDMDQFKGVEFVGKAGTENFDCVEMKMGMPWTFQTDFYGFCATMYVMMKGEYLVTFKYSQTDKIVPVKQLKRRMALHDLWTQLFEQFLNIPDCKQLPKWSSALRRMEDRLTEAVKVEPLEWKKALERFNAFAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJF0</accession>
    <name>A0A914HJF0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJF0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17182.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17182.t2"/>
        <property type="gene ID" value="Gr19_v10_g17182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052637">
        <property type="entry name" value="KLHDC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17182.t2"/>
        </source>
    </evidence>
    <sequence length="558" mass="63310" checksum="83E9A00CBF449A12" modified="2023-02-22" version="1">MRWMLSLDGGPRRVNHAAVAIGDKIYSFGGYSANDPLDSQNDFIDIHVLNTFSYRWERLPVLPYLDSSKETKTLTKHRSATISAPGSSDLAENGPSTSADSSSPLSDARRRRAKSLSDIHPLAQIRSANPPLEEADGLMANTVQQQYSTASRCNELLNGQNRSRSVRTRELIDEHSEEEEDSALRTFREAQRRMFERIDADMVELGSEIESSYGEDDSSLISEDSAEQHMEMDGEAIDMEMADLAGPGYLDGEFDDEDDNNVQDLVLLTKFHQHPEIPFKRYGHTVVAYRGSVYLWGGRNDKLGCNQTLHRYNPLENRWAVVPTEGQCPPARDGHSAEREHRFSQETYAFHFSTRAWNKLKTEGEPPQYRDFHAASVLDGIMYVFGGRSDEMGQLHTSHDVYCEKLHCLDLQTYRWNRPEVKEPMSAPCGRRSLTMWTYRDTIYLFGGYQSIRNTHFNDLWRFDPKSGHWAQLLPSGQAPPPRRRQCTVLVDNRDLYVLDFAPSLASLCSQTVIKFGLHQGNALNILPAIVMKELCYLSTPNQITKSHMPSSDSMTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJI3</accession>
    <name>A0A914HJI3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3 17">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Golgi apparatus membrane</location>
            <topology evidence="17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3 17"/>
    <dbReference type="AlphaFoldDB" id="A0A914HJI3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2048.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2048.t1"/>
        <property type="gene ID" value="Gr19_v10_g2048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00218">
        <property type="entry name" value="GlcAT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000044">
        <property type="entry name" value="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF65">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="15">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="16">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2048.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35910" checksum="A3D98691C0D2FC86" modified="2023-02-22" version="1">MPRIGRKFLTNIVLVLFSSILLTLFWHHILPGQCGVHNQCYFLKSNGDKLQQLPPIFFVTPSARRPAQKADLTRLGQTLANVANLVWLIVEDSPRPSKFIGQLIERLEIRAVHLTAETPSKWRLKYTDPHWKYPKGVVQRNAALRWLRKNAVDQRVGAVYFGDDDNTYDWRIFDQIRSLRRVGVWPVGIVGGMLAEFAYVNANSVITGFNAKWRTARPFPIDMAAFAVNITLVHDHRHVEFDFNSPRGYLESHFLRDLNLTRADLEPLAQNCTKVFVWHTRTEQVQFRAEEMSKFVDPNAEGLAEAEKDAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJN5</accession>
    <name>A0A914HJN5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HJN5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17506.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17506.t1"/>
        <property type="gene ID" value="Gr19_v10_g17506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12196">
        <property type="entry name" value="MARK1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14072">
        <property type="entry name" value="STKc_MARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000001">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049508">
        <property type="entry name" value="MARK1-4_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="294"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="19">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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            <taxon>Nematoda</taxon>
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            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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    <sequence length="224" mass="25144" checksum="BDD5DD4026D01F47" modified="2023-02-22" version="1">MLASTSSNTDINHCEHDDSHSFLMLPSTSTDKLKERNKCTADESDSDSDVFGDFEMANQTATNDSNGICAEEAKPSTEAELQPTKLDKIIPSSDQKVKHLPFTMQISQLLEETWKASKTEFDDILQVPPVDAPMANLFPLFSTDGADELTEIDGFTLKSFRLWEQICRLEETRLLQIRWDNSRGSELLMKALSSTRNEFKGPKSPKGKHLETTRTQSSCFKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK21</accession>
    <name>A0A914HK21_GLORO</name>
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        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
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        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
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    </dbReference>
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        <property type="entry name" value="Metallophos"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_4"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="31"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17594.t1"/>
        </source>
    </evidence>
    <sequence length="745" mass="83547" checksum="7F81D78CA63178EA" modified="2023-02-22" version="1">MEEPAPLNDGELDAIIAKVQMASAQEFTQNVSQEEVEQVCLTTINLLKRQQTLVEITPPVVVCGNIHGQFTDLERIFEAHGFPPNKKYLFLGDFVDRGPRSLQTALLLLLYNARYPESFYVLRGHHECSRANQVYGFYTEIQRRFGDTNCEHIWMLFNQTFSWLPYVGLVGGRILCLHGGISPIMRSLDQLRTLRRGLLDPPNPSMELDILFADPEQGVRGSSELIWLSALISAFFLEPNFSAIENSSRCFPPPDTKGKIIWCLHDITGIRFATESLNTQRRKRNLTPIQPGLNSDSKKFNSVEANCGQSPQSQFWPLHSISSDTLDNSEIQVRLAHPSVTQLLSRLVRDVAPILRLLYNFGVQDVRPLKFSVIHDRRFHTVFLNGSIVGVTDDGAFVSVSFNASTNALYLASDGGRLCRPYIIVENGCPCLTKSQIEEVQEDGKTRLSSVLESLSMNIKFLAQTTHLEIEPFSLLGIVSGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQQKKIDLLMYLLVFPQKPLVKTKTIELSNFEKLPAGQNSIVAVMSFSGYDIEDALVQNKASLDRGFGRCMVYRFAKGTARKRNCFCWGEDNAQTGAYQKIHAIDADMPFDQNGTVPDLIMKLHGRMAVGKLMELLSGCHAFTGDDMETDMLISGSTGQQMAAYVYFGPIYYQKLKQMLMDKLRLGGGRDIEQMAALPAVACASLTRTPLAAHLQRLRSAVQLVWERRGRRKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLL4</accession>
    <name>A0A914HLL4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2262.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2262.t1"/>
        <property type="gene ID" value="Gr19_v10_g2262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="256"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2262.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52467" checksum="DF49CF9B96BF78D3" modified="2023-02-22" version="1">MEPTEDATLGRRSSSRHSSTSLSSATSFDLVPTQANEMNDADNLDLQNEIEQNNNGVGSNAAGLHRQDAGGLANLDELVLQANVAALEQEQQKTIDLSHCWHNQNELRAQIVELQKSVAALTMAQNEKVPFKPFSRVQTKLDELEQSQKNYKKRFLSKEEFEEALNEVKQEMKQFEDTKQFKGALDEVKKELKDPNQFKEEALNEVKKEMKQFEEESKKQFKEELNKVKKEMKQFEEESKKQFKEELNKVKKELKDTNQDMNQIKEALKQINQLIEQLLANQSKESHSAGGSRKDLEFSGFDCLMVNHRGYWGNCSAVIKCQMPKSGTFYYEVKIVSKKGDIAIGFATKQKGFAGLFEHYECTYAYESNGNFWGHATNGSRRNFFIRSYIEGKPEFGSGDTVGCGVNLATRRIVYTKNGKRLDYGDLSVDCADLFPCATLFHSGDKIESNFGPDFKFKKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLT3</accession>
    <name>A0A914HLT3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLT3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2673.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2673.t1"/>
        <property type="gene ID" value="Gr19_v10_g2673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037364247" evidence="1">
        <location>
            <begin position="26"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2673.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29867" checksum="AE92E4C64CDEFCD6" modified="2023-02-22" version="1">MRIFLCQSTGLFSIFFLMGLRPIAAFGPSDFFAQLAKTDNESKLLSEINEKFSNGKEIDQKASERLAEYLLTKVGNVAFIQSVLEETRKYGEKLPKTSQLPNAFIIANTVLEQFELFCKEMTKSLENGAVSVKEDCLKLGPLVVFIGLLNPFVVHPGGFISRLDSFVKKNQNEIQSNKSLNNIFAVFFDRYKKEWEIIKGKVVKIMLKKIRKEIEEKVQKELVEYAEFFWNEIKKISTVVEVLGLKNCGSEFIPIRDKMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM32</accession>
    <name>A0A914HM32_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HM32"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2039.t3">
        <property type="protein sequence ID" value="Gr19_v10_g2039.t3"/>
        <property type="gene ID" value="Gr19_v10_g2039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="165"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2039.t3"/>
        </source>
    </evidence>
    <sequence length="326" mass="37106" checksum="13EB3A6C1CE74474" modified="2023-02-22" version="1">MASKSKSAAAVLLPKTKFSTMVKSIERIKLDTLGQFDSTSLQWPKKWRMRMRKRRLRTRTSLAAPKNNKDEVGASGPRNISDFYGRIVHLRATKVMLALWEASLQLKTLHALQTAVVGQANLRAVTFREWNVTVDNDFTQIKSKIAEFVDFSEERERDEQFCGQFAEAYGAVCDQLRGAGEGEEYLGEKKKVVTLLNVLYLAIDSVVDNFEVYKVETIGDAYMVVSGLPERTTDHASQIAQMALALLNKLRISRTKFSEKLRTEPELFRNPNAPIQGTQKGDVYSFAFILHEMLYRKVPSTGATRRARPRFSRKNLMLKEAEIIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM88</accession>
    <name>A0A914HM88_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Folate transporter 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HM88"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2086.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2086.t1"/>
        <property type="gene ID" value="Gr19_v10_g2086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF20">
        <property type="entry name" value="FOLATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2086.t1"/>
        </source>
    </evidence>
    <sequence length="421" mass="48011" checksum="75F5DBDD8A66063A" modified="2023-02-22" version="1">MYWKFTVALACAFGVLKKFRLGAPFLTPFLEAEEFKNFTNAQVYGEIYTFWTYSNLLAMLPILVLTDLVRYKPILVLEAVSLVACWLLLVYGTTLWQMQLMQICFGIATASDIAYNAYLYSVVHKKHYKKVTSYLRTASMVGKFLAFCSGQALISTKIGDYLLLNQITLWVSYVLIPIALLLPMPKKQKSKEMIKNCSVEQQQQKEDLLEQNLANDRDKMDDADPENKANANTDHANDEKVPESEVEEGEKNGKNWHLWTKIKTTFFSPYRNRVVFHWSLFTIIISTMVYQVQNYIQTFTLVFCISTTFMALLLYAMVYFGSIFVDYILYIVLYMHYNAFITVASNLIATHLPPSGAYGLVFGINGFVSVLLQALITLLVVDANGLFALTIEAQFVTYSAYFIATSLLLPLLKLSMRRCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN11</accession>
    <name>A0A914HN11_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HN11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3007.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3007.t1"/>
        <property type="gene ID" value="Gr19_v10_g3007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="2">
        <location>
            <begin position="420"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3007.t1"/>
        </source>
    </evidence>
    <sequence length="507" mass="53913" checksum="B9F7389DB851B60E" modified="2023-02-22" version="1">MNSPTADDAGFDFVTESGEMDILAAAFGKGHNIGEKEHGVDGSEKAQTKSDELEQNEQRQDQKELCVQIGELNKLVGPGAVEKKSTQKCAVLASMATALNKIATGGGCPGVPDYASMMWLGGKDYASMYTGNGMNLSNGMNLDNGTILGNGTNLGNDTNLGNDTKLGNGSNLSNSTNLGNGTNLSNGTKLGNSTNLSNGTNLSNGTNLGNGTNLSNGTNLSNGTNLSNSTKLGNGTNLGNGTNLSNGTKLGNSTNLSNGTNLSNGTNLGNGTNLSNGTNLSNSTKFGNGTNLSNDTKQTFAPQGKFDICAAARANVVASGEEHRKPLTELEQLFLICPENRWNSSDCHPALSVIRPDCLTVFRHDPAVAFIASVRADLMIPRHHCGLFYFEVTVEKMSKLFHFGLVPKSVPLNNAYASYSYKNAKFGVGDVVGCGLNMATRQMIYTLNGRRLNTTDLLVHQSDLYPFISLKDAADRGMELKLYKEQLEDMKWLKTTTAGMKRLNTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNI3</accession>
    <name>A0A914HNI3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNI3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3155.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3155.t1"/>
        <property type="gene ID" value="Gr19_v10_g3155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037379833" evidence="2">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3155.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27566" checksum="494517424C83B9B2" modified="2023-02-22" version="1">MDEFWNLILVLFFVTNSLDKAEPVKLELKTFDEIFGEGWWDKGEAEELKTPAPTNFGQNVHHQINRQNTQIGQIEPNSTDQNPLLTASDHSDNAKNGEEMNSNEKQKFDQRKAELKLDGFKNSYNHEIDETIAKELGLSLKTIYNWKRKFGQTKQNKYPHNEQKELMKFYYEIKDQNPKIIDGEIVKMLKIGTDTLCRWKREFKRQQFHPNSVDGNSVEENAAANVQKIVNSNSESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNL5</accession>
    <name>A0A914HNL5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase PGAM5, mitochondrial</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphoglycerate mutase family member 5 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Serine/threonine-protein phosphatase Pgam5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HNL5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g318.t2">
        <property type="protein sequence ID" value="Gr19_v10_g318.t2"/>
        <property type="gene ID" value="Gr19_v10_g318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008544">
        <property type="term" value="P:epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032486">
        <property type="term" value="P:Rap protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04175">
        <property type="entry name" value="Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000182">
        <property type="entry name" value="ras-related protein Rap-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038851">
        <property type="entry name" value="Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
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    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00013081"/>
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            <dbReference type="ARBA" id="ARBA00022787"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00040722"/>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g318.t2"/>
        </source>
    </evidence>
    <sequence length="467" mass="53661" checksum="D5DE7ED73039CEAE" modified="2023-02-22" version="1">MSSNCWRLLFALQQAGKKNADSNSVALHPFGSGEVQRWDHNWDKRDPFSLIDVEAFRVADEEKQKEMLAKVTPTATRNIFLIRHGQYELDSKKRELTSLGREQADILGKRLAGFEIGKGHKFNKCVVSTLQRADETAQIALKHLPHVAEIRKNTDLLVEGAPCEPEPPSSSWRPQYYSYTDGARIEAAFRKFIHRAKPKQKEDSFELFFFHANVIRYFVCRALQFPPEGWLRLSLVNSSITWIRIQPDGRLMKQITRSARRSDATAQCSDFIHPIHSLSRMREYKIVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQLEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFVLVYSITAQSTFNDLMDLRDQILRVKDTDDVPMILVGNKYDLEDERVVGKEQGMNLARQFNSAFLETSAKQKINVHEVFYDLVRQINRRYPDSGRRPSSKKNCWRCSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPI0</accession>
    <name>A0A914HPI0_GLORO</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="Gr19_v10_g3225"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
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            <dbReference type="Proteomes" id="UP000887572"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3225.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25877" checksum="5EEED03680758481" modified="2023-02-22" version="1">MKEFLILILMAFFASNSQDKAESVKLEETPLKTFDEIFGEGWWDKGEAEDLKTPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQIAEDDKKQKFDQKKAELMRTGIKNSYSNQIDAIVAKELGLSFATIYKWKRELGQTTQRKHFHGEQKDSMKRYYEIKYQNPKIIDKEIAKMLKIGTNTLIRRKKQFKRQQFHSNSVDGYSVEVNASGSNVQEIGNSNPRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR52</accession>
    <name>A0A914HR52_GLORO</name>
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        <submittedName>
            <fullName evidence="3">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
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            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="Gr19_v10_g3479"/>
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        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
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        <property type="entry name" value="JAB"/>
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    </dbReference>
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        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3479.t2"/>
        </source>
    </evidence>
    <sequence length="138" mass="15553" checksum="A297C982CF045C99" modified="2023-02-22" version="1">MFACSLFWKSSMDQNLAFRKANLRSENFGTRPAQNGYARAQWGNIEIMALMQARVDANTLIVMAGFALPVEATETRVNAQAQAYEYMTNYSESCEPVGRLEKVVGCPLTNNTRLPVPFPIAEMKQLNTENLKQQQNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRK6</accession>
    <name>A0A914HRK6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g381.t2">
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        <property type="gene ID" value="Gr19_v10_g381"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Anti_prolifrtn"/>
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        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
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    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
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    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="415"/>
            <end position="525"/>
        </location>
    </feature>
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            <begin position="1475"/>
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            <begin position="2484"/>
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        <location>
            <begin position="2195"/>
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            <begin position="2399"/>
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            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1512"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1614"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1743"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1973"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="2008"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2023"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2036"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2052"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2313"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="2327"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2337"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2354"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2484"/>
            <end position="2505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2519"/>
            <end position="2538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g381.t2"/>
        </source>
    </evidence>
    <sequence length="3069" mass="336374" checksum="B70D03CA9D3B7EAD" modified="2023-02-22" version="1">MYTEILELVNFFARFFHLRIPRLKIGMFCEHFANNCFLRFHLYWNLNQPKQYEELRIIRVSHQYTDELFTSAASAVGLQLDELLSCIPERLIIVYVNPGEVFYCPGDYSPPVAVWVGPVCEDLKYNETCHVTFPPPPIPSSILPTHAIQPLIPRPTSNLPGAGCVNVTVDFSVLSWRIPLGLVHPRELGYATNPTSDFLMFRYCVPGTPNYTVETFASTRFGSYRKRPDYEFFTRLQHSLLLLNAQSSSDDIGRTFPLATFYRLVFFPLSPWALCPSLGFFPFGAREFLLLNISDRLIFDAKWVSSELGSKRRYNGLLEAEHHSEGSCQGFSMARRCDTTDRHLPQMSHLIFFLRPIYQLEHFRNVLAVLLGNKSKRTICNSEFKAAKAGMKEEALTGRRQHRDVQKHKFPGSNSELIPVYTKWANDLLQAADLPPLTDLSGELCMPLKLIVLIHSITFEFQKVPKEQLIALLSHNDALISIKQSLAYLCQIGVPLIDSIQAKDIRNGHLGAILQLLYQLSLYHCACQQQLHRQRPEEAPQQKQWPNRSIRPSSAGRTCYTTASSSTITPTNTRTNNNLPAEEKNQWENRTVETSASRKVAFKMPPDASLTSLEGANREGTERKGEEQEMASNVRLSRIASTHRSALRPPQISAAVSSKRSVARPQPIELLEAPKALGTNSSRLVPPSSQRSSSQSANTSPKGLLRGGGTDIIIDFVPPALPASKQLPPAAGFQTTNRICLPIPTVLTPEKKHSLCPEVTNRNSGRNSNGGLSDESKRTAPEGPNFVEASIVCNSSSQHDSSVSPTVHQQLQFQKSVLRQPTPSALAGRSKSALRVPISSIRSVNPTSDELNEHSPKQTGQSLPQHHHHSSSSSTSVPVLVSSSSSLPTSASSSLRTSQLRPPIVSKPVPPKRHTSTVIRSSEERLKEEPREGEATEMNRLRLFGGKDRERERKREKVSAPICIGPPSTEQHEAHQMPSYPPRGKDLPDQNGEINKLRKPTSTSKSLLMPPSSTVSRRVTATAGGGVQPTSGRAASQQLRSGETAKRGAGGRAGGGGGTTASQQMNTSQCSTSSNGGRKSGQLKKYSQTPPSLMTTSSSSSSVGIRITSKPASSNSKLTGIPSAKKTKEELSGNKTDSMTKEEETMRTEQQKCQAANSPPTTEKKPILAVKGISVPSGGTPSPAQKRPSLCGGRPSSADSASECPRSPLMSDSRRNPHMVVGVVSPMMHQQEEVLGGTSEANRSEERSVVDQQREKDNPSECEPSAIQKPPEEPIVVNSEMEKWNFPEQMLGLSDGSPPIHPEKVAKISKLAKAVPAKRLIIPTMASQILPEGTMEEQNIGGRKVPSEKCRGEECPSPSVPPSMAPTKLMSVLREEQASPCPSSSLSTPAEEETNRCYHFDKDHPNHRCQDGHSSQQHQKVSPDELISAAVATASDNSTDSVRTTIQIHCFSTKNDQLGELLGDCAIIGGGTAPATAEDNDGQQNLHKNGKGGIMGQKMDGEEGEGRRKMIDSNNGKQQLATEGAGKDAVGVISGGATSRNQHHYPDNPPMSGTADYASESELDFRRQPMARHLYSTSIPAGNKLVMALDLRPNSGTALRGGGRKSRFRESYEDSSSLSSGLSEPFDDDISTDDLTGSSSDYLLGQLSPNKMRQFAHENGQKHIDFVSFQKPNGPQPNSMVSAAERERQTAGQLLQKCKSAQRGCAYFGSAGGGGPIVDPHRPSTSNGYLPTPAVGHFVHNSAEGRRSGCDQHHRIEQSQHPQKPYQHHPNEQLFALREQGQQHRRQQQQQPEQQNQQQFDLFRPYHTITAVDWPPLQYQQQQQLSRTHRPVDARRLLSPPHNLMVLSDDGDTLSVAAGDVGERTTRGQSARPPGATLLGTQQQTMAATHLQNDLLHRRQHHQQHPAYHTHSLDRHAHLRVLSAGVRPLPAAADDHSPRQGQFANISRNLPHQRLQLNSLLISPRHHYSVNGYTSSTFAPPGNTNATSSSVHRRSRGGDLYGYSNGPLLPPQCFPPPPPPGSSARSSVASGTPHQRSASLSAMSRSMVTVLEQHEERQRRRGRGDGGETQRRVLEYVRGQLEALNSNARGDVIEAPPADKSAKSSHPPLPIPPQQRSSPHLNRRTPLSLPRQLELNNNHLHSAGSLSARGTDGRIYSNLKFPNSGVNSPTRLPIQQPGSQLSLASSIGSTYSTIEERYEWEIGKLQNELESYRTHVQLLSQKNSGFNCVIQMFDNRLQSIMLALGKLQQKQNVKRDEVERLCNEIEQLRALSVTAGVVPFSNMEGAACTLKSAGAKGDEQQQNGGGSNKKSWKTNVDTQIRSSFNRAFHKGTKKSKQQQQQLQPLKDTTDNTHSSFPSSFLNLANNNNSSSSSMTSKMDSTKRELETRELALTDVQLDALDKAKEIDILRETVNRLQHENKLLKYNFSLLERRVHSESRASSHLSLNTTCMAGPGLDFDAATLEEVLVEAPEQLAALYDLAASSPSSGDISVNTTTTGSSANGAQQFVPAELANKSTDRSSFASSTTSSKRSSRGPSTALPSAKVVLCVDLSGRLDSPHPLGHLMSLPPSNSLCSISRANSGSSSTLSSQASSSLGSVMSGAAMTSKTGGTARRELTVGYLPLPVGSATSWKDLDQKLGLLLEEYLHRIDPDLSLGIDSYSSIIGYQIHPTQQQSDTGGHSEIFLIRRRGSVSETGQQQQLVENCAELGELLPKLSPAEALQPGTLIRIRLKGVVQHSVDALVLESLFPRHLLEQLLYQLEQHRRLLLFGPTGIGKSNLARLLAKYLLMRLERNNNNNPNTSKALVDIRFPMDGEKHRQEGNQQQKVKEQLIAALRPASNTAVLVMDNLQWKRLGTVLEAFNNSAAGEELLAGASVAADLPLSSPFVICTLNRTCVDHSPVQQLQLHHNFRLFALSYKMDAVNGYLGRYLRRRLAEQELSSYASLGPPALCPSPADPLESVLHFLGRSLRAVNEFIERAATGGPDLTLGPRVLLQCPLSSEEAQGWFVQLWNDKLVPYMRKVLTESKAFPIPAVDGDDKVSAFAKDPTDEIGTLWPWTGGKEQLLKICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSY9</accession>
    <name>A0A914HSY9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSY9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3680.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3680.t1"/>
        <property type="gene ID" value="Gr19_v10_g3680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00698">
        <property type="entry name" value="TMPROTEINSRG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3680.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38067" checksum="FBD0B8AEF72E48E8" modified="2023-02-22" version="1">MDFDDCILSMALYIAEIVTIVRHKKFHNSFYALFVMRAIPDWLGVMVSFYGQRLPSIIGAALYPIYAKFPNWMLAMFYFIVGHTFQANNLVTAFILLNRLTAIIMPIKHEKLWRKFFPFITIFVYFVPTLLCWPVLKMDGILRLDEPNSTTDRSFIVFEAGEAPITNYLAYICAVFSVIFMIICVLLNICTFVAYKLHVKKVATNGNNVHNIERKLLIYALVTFLGHALVASMFLIDIITNLDVPKTKALLFVYYPLILDTGTVVLASWLLLWASGTIRQQLIKDFAIIRTNIQNIRVGPMEGPGNNNHRAIGGAVGHQLQNRICIPVQQLPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU08</accession>
    <name>A0A914HU08_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3970.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3970.t1"/>
        <property type="gene ID" value="Gr19_v10_g3970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="967"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1538"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2277"/>
            <end position="2364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3970.t1"/>
        </source>
    </evidence>
    <sequence length="2364" mass="267080" checksum="924029FC50D4411F" modified="2023-02-22" version="1">MRRTFFRGTPMCAARFFARSSNCAALWPLPSAAGRDARNEGIRLDREGNVMERNNPPQDQNSDGENLMDGSHEMIIPERRMDEQQLREQLLNVENPENRDEMNGNADDNEDQELQNRGFASILREYADNLGRGERNEGNEEQGVQQNFGERVRPPLRPRTSTPVLEVNGNEWAPRHFLGHNLVRHGVEVRQIRHSAVISQGQGYRPPQDFIEQQQYRPVQHQGTSQYRQPPPPIFQQGDFNNLQQRQNPQIAYAQAMQDQHGRNQQFEARGIAAAQPIVLQMPQQVSGNIDYGIVLERIPDLNGTEGSDGVKKFFKKFDFYSANWTDPQKIRALESKVFRRAERAFESARNTQPHAYAAIKREMVNLLEESDSNNLNSFDALMQGVRRAPSESIDELANRIAGLVHRAYAGLPQHLCEEYAIKFLIRAMNNPEVALNLELVRAPGMSLDQFVSLAARAEATQKATKRFSSHGETQGKLETSGQSFFRPKYSQAVGPSPMSARFNGQAQRDQGWRTQQYQPQRQWNCYNCNEPGHLARDCTRGRQQRQPEQQNPRFTEGNQPNVIATGANRTRAGETMPAGNSGNRNGQFQARNFLKQNCLVLQQEDVHRNEPLLGELTEDMGSFFEALKSSATDNSKPEIPMIGKVMAVQVEVLGVETKAMLDGGAQISVIEAKFLHELIRDQKLNLSGLEIFKPETRISDANGRQLKCLGVVCLPILRKGGAEKVNVAVHIATAAIGFDLLFGTNALKDLGFKMFDATNNALIDFERLKTNKTDSLTVIYKTVLEPRSTKMVEFGIHEDFEGKEILVSSESEKQVRVEPSVGIGRDKKVVAPVTNFSNSTMVLEKGNIVGTAELVQDIGEAENFLAAPAVCFHKIEVVKEDKSIEMQKIWTELLEKGDLGEPEATQLDGVLQQFEGIFAISDEELTQTDLTVHQINTGDETPIRSKTRPLPYAYREKVASMLQDYLNRDIIRPSQSPWSSPIVLVPKRDGTLRFCVDFRRVNAVTRKDSFPLPNIDNTLLMLGGKKFFSTLDFMAGYWQIKMETHSVEKTAFTTEHGLYEFTVMPFGLTNAVATFQRFMTHLFEGMINDFLFVYIDDLLIASESFEEHLKHLDVVFCRIREAGLKLKLAKCKFCTKELPFLGHLLTRDGIKMDADKVKPIEKLPAPKSRKELHSLLGFLTYYRKFIYAFGTIAAPLFRLLQKDVKFAIGDEERRSIDKLKEKILSDVILYFPNFEKARNDPLRCFVMMTDASKVGISAILCQHDEEKRLRPIYFASRQCNKFESRYAPTELEALAVRFGAKKFAQFITMMPTRVLTDHKSLVGMFRSKTETGNARVDRWLLELNSKFILKVEYQPGKKNVIADLFSRSFERTGQEIVEPTDRKHIAVLGALRVLGKEPKRGVEEEREKWVRETKESEMKHIYDFLEKKANPEDPRKAQNLRDTCHRYAILEGLLYLCEANGKLRLFVPANFRDNLVKQRHEGKCAGHMSSKKIYLQLTEQYFWPNMLKDCVKLHESCRICAHTKDARANEPPLKVAQTSEPFEMLCIDILDIGPSQSDFKYICVMVDHFTKYMIAEPIRDKSAESVSKVLVEKMILIYGSPKKIHSDRGKEFVNATIEEITKILGIERSVTAGYDPQANGLVERMNRIIIGMLKKSTSSCWTWDERLPYIVFSYNITPTKTTQFSPFSLVFGKLARFPLDGKVPMPVNPVYTVDCDTYIQLFRENFLSMLNEARENSREERERSKKWYDSQPKVTANKFSVGERVMVAFPGLHRKSRHKKLLWTHFGPYLILEIGESSAVLVQIDKQQAEPIKVPIERLIRVPPGIPDISTIPRGKNPFKNVLNTLVTGTPNGEKRDKREPNSAQMMQLGTIAQVKGGDERERDGKVPDLVVKLGKLAIQSFPETMDVDKPEDSVFGWNATCTEGQGEHEFCGALSMLELDPALGNAGLGTMAVKTPLQALFAVFLLKAGTVKSMTAARNLAQAIVEGDPKEELRLFVAKRGDYVGTGLYPTEEDQMKALESWFEKCSVARRALEESEFGRIGMQGPEGIEALAESEKKKWKELLEATPWVLERMRAKIVHKATRFVAHPRVIIGDFSANQLGEVLDQTAIVGPKEGTLAEVVRSLKPTVLSSKVKAALIIAGRDSLLAGEPIEVMAEQFEMIAKWCRRFPHVQFLWTCPPYVHNKQSEYEELVARLRPMMSQPPFLPVWVTENGRSIGEVFRFGNSFDNLRVTADGLMKDAGVRALKAWLFTQTEFPGDQQLKIRAIHSVVRVIPSGGPGDHRRAGNSVGTASGGSGDPRRHSFGSAGWEDFRRRSQGSGGLGGPRRHTFDGSTGAGRFHPYGRGPLRGGNDQRGQGPQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVM4</accession>
    <name>A0A914HVM4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Calpain-D</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4905.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4905.t2"/>
        <property type="gene ID" value="Gr19_v10_g4905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF382">
        <property type="entry name" value="CALPAIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="11">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="12">
        <location>
            <begin position="235"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4905.t2"/>
        </source>
    </evidence>
    <sequence length="765" mass="86437" checksum="C9632D2D7EEBFE4C" modified="2023-02-22" version="1">MHTITKNWSCQRCTLINRINETKCRACQFECPSISGRSGFLQKIKFPRISLNSALERVDNAIDFVASAIVPKNGQNVQFYQPPAFLRGHPQPRADPAFSTANPAFWVLPMVTLPQPKLATWACPNCAQLNPASVKKCSWCETDRVTDVTISYWCCSNQRCALRQPFPPSDLKCPLCRTKTSALKSGCSKSMPQLSRPQTNVLNPSDYGPVEECQILTHTSTYRDILRFCENNRQGFVDDSFPHSNRSIGTLSQLERRDLSIVWLRPEQIVTRDNRLSRWSVFNDPQPTDIEQGLLGNCWLLSALAVISERPDILEKLFITKEYTHHGVYEVRLCIDGIWQHILVDDFFPCQKRSRQMVFAVGRKNQLWVSLIEKALAKTYGNYAILKAGRTVEGLSTLTGSPTLSIDLEYVDLDRDSRNAALDIAWAKLISAREARFLMGCSCGAGKRTVDEAEYRQVGLMSQHAYSLLDKKHTNREWPGWTQRLRRELPSGANLSAGTFWMPFERFVLYFDNVDIAQTREHSGGWVATRYLVDIGWDQQNSSIIRLTITEPTELCATLFQHNARTALDQVDIMLLLHKQEGEITPGELICRSARKIAPIVRTDDTFLLLGEYLLCVHSFSKFGDQMMPGTIVVHSSRKIFIEKLPTTFDSLHRSMCSLMLKEGVVQKSCSGTVSRYLTNEFAGLALMVDNHNVDCCMQVKSDCQSSTNVLSTRSSLLTVDSIPPLHRQIVALLTHFEPSQAFMNFPPLQTEAVGHLHGPSPIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW95</accession>
    <name>A0A914HW95_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HW95"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4602.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4602.t1"/>
        <property type="gene ID" value="Gr19_v10_g4602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4602.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="21169" checksum="26830DE43174A44D" modified="2023-02-22" version="1">MPPSYPNPLPMPTMAQQQQAVPLPYFHQIAPAAPPNVHLRMLAPPAPANPNLHHVPPASPQNQHFHHSTQAGQKKLLGALNELLGVAKAQQGLMEKLIVAVTANKIGQQVGEPVQNGNVRRRHQRFRQKFGAGTFPPGVNQGGVAGSNRSHFPGRGSRFQANRGPVGPVGVVPNPTLSDQPAGTGPAPAANEIASTSAASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWE8</accession>
    <name>A0A914HWE8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWE8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5107.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5107.t1"/>
        <property type="gene ID" value="Gr19_v10_g5107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5107.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8125" checksum="F87800069A84323D" modified="2023-02-22" version="1">MPTQHPCYGLRECRPTSVLTRMPANIRVMVFENAGQHPRYGLRECRPTSVLTRMPANIRVMVFENAGQHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX18</accession>
    <name>A0A914HX18_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g4817.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4817.t1"/>
        <property type="gene ID" value="Gr19_v10_g4817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13244">
        <property type="entry name" value="PH_PLEKHG5_G6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF11">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="668"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1520"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1715"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1523"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1730"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1772"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1792"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1857"/>
            <end position="1871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4817.t1"/>
        </source>
    </evidence>
    <sequence length="1894" mass="204080" checksum="DD9F7B20BF103777" modified="2023-02-22" version="1">MRLEQLYDRNNQPSSAVGCHPTASLVFQARHAHSKSANNSSPSLFGGGTIVGKKAHAATEVLRSKRASSVSAGQAVEYITVDLLASTVERSNSSGDIGSRRTIPTEGTGTAQLIEAVPGRKLIDSLERYLQMHGIPAQCAEFLLEKSSTPIPANSDSFFLAGHKVFVRVKRKEEQRLLLGGVPGGDNNNLIIRHQLQQPQHRRGNHLITSALFGGGGGSAVYQPHQINQLYQQQQQQQLNKGLPTRLPSCASYASSSSSSTEVATTTTTTTTARRCRVPSSSPQLVAVSSGAPQATKLISGISRALLSPPAEKVGDESPEKGQSPDETTAQLPQSSIRRRGSASSSVASTLSSSSSSSSSSSTASTSSSHSSALLPAAVATATAAIQSLPAAVPDTPAAQSQHSSTTTAASHQRKNIKMTKHSAIISSCETPPPSGAETPSADQQQPSHHLQQQTVTESTADEQHQPPPKRKSSLNSLVASALADAPATLASIFNVPNSSSTDLAQNNEQQQQNQERKSEQAPPPPVPSVMHSSSFTLPLRSNNSGSIMNLHQTSGSEDFGTRRSAAAVAAAGIVGGGGSGGRQMSVSSAGGTISGASTISAGSGSGMTTIGRKGIFFAREKLTSAHLEKIYAQAIANRSNDLSVLELETHWTTFVHINKLLNKRQSDQQEALWEIITTERRYILQLQSLEDMEWCFVELQKQGFMRDVSRQCVFLNYSQLLRCNLAFWQCAIMPMLDRSRQNHEPLNAQLLQPGFDSIPDWSFCYIDFIIGHADSHAYVQKRHKDNEVFTEFVKWAEQHTMLNRQKLVDVLSSPMQRMTRYSLLLKAVQRSAADTEEKITIQGMIECAEAATLRLNYEMNNNDLRLQLSEIMKTIESYDVVDNDEFERLFPLPTAPVPVQQLAQQSNQHQQLLAAMSRPPPHFNLMLPMPFIGGQPRFRRMYTRGDLKMREGRQSPKQEVHCILFTDMLLICRMVSRRTDRLRVTKPPMHISNLRFHHFSEGSGFYLICMNEFESPSQFLLMFTATVEETRRWLEMMVMAQEEFRSLRAANAQNNGYYYEGCFGSVERLFCPPAGTSCSKCDQNTNKNSTTEIFGANLRRGETLRAIPNLSKQQQLAQQQCCCPLADPSTSSSKHQRCTKCRGSAERGTNNGGNNDFEGVVHRKSRSMDSQVIAENRQVMAAAAAGSVTAPAQCCPQHQQRTATLCTSAIRASADQLLEQQQQKCCNCNKSERRNDEEDPKRTDCCGTTRSVDEHLLLGSGDGGGCARFTRKSGRERQERLERQQRLACWTEPVNGRESANDARAAEASRKAPAPPEHEEGQQCSSSFASIERSESASNNGPSSNGGGGGCSAVADAHSQHIVHALSQAASTAALIVASPAGGTAAHNNKKAHKLSLNFTANSVPPQIGGILAAAGTSTTISQRRFERRYHTVGEIETGRQTCQHQKVCLSAGGGMVDNACGSAVGTTLGHHPNCAGGGSAPGSTGILKRFSWNVSSAMGGSSRKISSKFLELNGRRFSSQSTMGSLSSESFGSSTSGISSTSSLHSSHCSASSTRPSPNQHQWKQCHEDVGTPTTDHPPMPVEVGGTTTKASPSLVTMHSVCSTASTLIEAAGGGGGGTDHGKNDEDNATEEEGEAATVAEQPQERSSGPKELDEKGAENAIVNDDNGEATKNDQCQTHSFCCNEGAVAHKLVIGVCANSFGDDVEKMANKMEQNEKAPPGLTAENGPLPRQQEQPKQPQPFCIRLDSSPMSPKLEENSAEGINQNDSSPSPPPLPKTQPPASTPSSAGTEEEAETEEEDALKLRRQRHASSGKSAKNGKSNRKTSRLMQMPPIPPQPSQHFASQLRQPPPPLPSRQKASCAASNFGSNGSSGGSSDLMRFILDDKLETSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXG3</accession>
    <name>A0A914HXG3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4686.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4686.t1"/>
        <property type="gene ID" value="Gr19_v10_g4686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4686.t1"/>
        </source>
    </evidence>
    <sequence length="1081" mass="119907" checksum="A9A93348BA7C004A" modified="2023-02-22" version="1">MSAHFRATISIAHAEALEILNDSRTFPVPARSPGQTEAEFSCLIQNCLRDLADEDTYTREITAQIADPVDKWMALRTNMTGAERIQDNTLFDDFVAANPYPQTLKRLRDYSRTMRSQRRSLEAAIPQSTPRPASTNMNDSVIHLPKTELPKFSGDCVQYQSFWNSFKSSVDDLPLTDSIKFTYLKQCLSGPPLTLISPLPISDLSYSSALALLKKSYDNPEDVARSLHNSLRKLPRVRGGDSFCPDLRSLLDQIECICVQMSQQNQSYDTTPFQMEVEQRLPRFVLDEIFKAKEEEADWSSNKLKDRLRTILRRKEQIDCLQPKSSPARPPYSPNPGGHAHPSPSFDQPSGPTLTFNTQRGKFGPSQQRPKPSLPCLFCNNPAHFSSSCPQYNDPKSRSERLRLLRRCYKCLKAGHFANQCPQPATCPICKGPHPRALCTRQNRSLPPQSSLYAHYAAQREPHSPNEAPPRTNNWACSSSMPLSLPFPPTPLLNPQAQTAPSPSAPSSTHSGQTDRSNVNPSQTNTSSIKSAQPLTQSPPVLLKCVRVTFFNPENETLSQSGVLLLDDGSTNSYISSQAAEAVKLTLTPTSICLGVFNSPECKTLPSFSTRFGIRMLNGKSLIVKANAVQHLTQPTQFVPFTPELLDCRDLLPNLVTARPVILLGSDYYYELEPIPTGRLPSGHHLIQTNLGPLIAGRASPCPPNTVSPTTQISNFSTQLPLAPADFFSLENIGITDPLEPLSDASVLQKFTDEIEFAENRYQVKFPFINPPSTLSLPTNFGLCWGRLRNTLSSLSKTPSLLSKYNEIIQTQKTLRVIEPIENHHKFSPPLHYLPHHAVVNEEKGKVRIVYDGSAKIPTELALNDCLHAGPVILPQLVGQLIRFRLPMFAITADIEKAFLQIAIHPSHRDCTRFLWLKDPALPLSYENLQIFRFARVPFGLTCSPFLLGATILHHLSLKPSPLSAEISSNIYVDNVFLSAESPAEGQEKCSSAISLFQSANMNLREFCSNSPKCLALVAQDRRLSGFSQKFLGIDWATDADNLVFHSPPNIVICSPPVLGAQGQTHSGERSRKVLPSLPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY39</accession>
    <name>A0A914HY39_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large ribosomal subunit protein mL42</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY39"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5100.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5100.t1"/>
        <property type="gene ID" value="Gr19_v10_g5100"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019346">
        <property type="entry name" value="Ribosomal_mL42"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10210">
        <property type="entry name" value="MRP-S32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5100.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15709" checksum="4067D57701E70654" modified="2023-02-22" version="1">MFTIIRRHLWTKLDKCEWQTVMCSNGVIACWHPPKQFPYEHSRPFNIKKALMEKENFLNRKGDETFGTNGPDDLALREIFYTEMQEWRPIYREKRLYRAKVDDELKPILSNPPNLPGLEGRASDEKDDKLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZA9</accession>
    <name>A0A914HZA9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZA9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5172.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5172.t1"/>
        <property type="gene ID" value="Gr19_v10_g5172"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="36"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5172.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23856" checksum="70393A227EBB00BC" modified="2023-02-22" version="1">MLADRKGWREKRMLADQKGGIGRRGCWLIGKGWQGGKRMLADQKGREGERGCGLIRREEREKSMLADQESGREGEEDAGDQKEGGKEDAGRSEGREGEESAGGSEWREKRMLADRKGGKEKRMWADRKGGGRRGCWLTEGREEKRMLADRKGWREKRGWRAAQKGGRERDAGCPNRKGREEKEWMLADSEGRKGEEAAGDRRMEGKRCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZZ4</accession>
    <name>A0A914HZZ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZZ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5633.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5633.t1"/>
        <property type="gene ID" value="Gr19_v10_g5633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5633.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7564" checksum="041D6B919FFB3095" modified="2023-02-22" version="1">MSSPHFNKCQNDFLQSTENFRPFNTSEFAGLANFACGVDPLSTSLDNLEDLVPDQHLAMEEPSVGCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0Y4</accession>
    <name>A0A914I0Y4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I0Y4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6481.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6481.t1"/>
        <property type="gene ID" value="Gr19_v10_g6481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF1">
        <property type="entry name" value="GH21943P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6481.t1"/>
        </source>
    </evidence>
    <sequence length="539" mass="57440" checksum="0E969B2C975F187C" modified="2023-02-22" version="1">MSRRARSLFCVSRRRMSAASAAVLGSSVGGATRAKREASLVHALVVIFLEFFSWGLLTVPVINVLAETFPANKFLMNGLILGLKGILSFLSSPLIGALSDVCGRKPFLLLTVFFTCVPIPCLKISAWWYFTLFTLSGLFSVTFSVVLAYVADITERHERTTACGLVSATFAASLVTSPALGAYLSSVYSDNAVVLLATGIAALDLLFIALCVPESLKPVAGGEGGGGGAGGAAGHSPDSASGRVSLLKIEGTDPLFVLRFLRDDPTVLRLCAIVFLSYLPEAGQFSCFFVYLRLVVGFSPEAVALFIAYVGVLSVFSQTGFLLLITQRYGPKSPITLGLLFQFIQLVWYGLGSAHWMMWGAGLFAALSQTSYPAISAFVSLQTDKELQGTVQGILSGIRGLCQGMGPAFFGLIFYAFNMDLSSDEESAGHIGVGPQFPVPNIRLPPFKQIIAPNKSSAQQERLKPFNDEAMGLVPGPPFLCAALLVFMAILLNWSLVPARKRLLLLRRGAGGGGGTSRHHQTDAATLLIDDNGEKAANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I103</accession>
    <name>A0A914I103_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I103"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6494.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6494.t1"/>
        <property type="gene ID" value="Gr19_v10_g6494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6494.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8135" checksum="99CC1C0A5425E0F5" modified="2023-02-22" version="1">MRGTPEQRADNKMPWGGECASFPRRGGRFAHKKQQQLDGWLRGEQRSVETAKQKQIGATIVVATHCQNDLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1I8</accession>
    <name>A0A914I1I8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1I8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6021.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6021.t1"/>
        <property type="gene ID" value="Gr19_v10_g6021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6021.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8349" checksum="0814D63D39793D10" modified="2023-02-22" version="1">MDITQQIASEWLTLSDAYAAAFALFLSNCRLFSPSACSSLSFSLLSPPTFSCLFSLLLLLPIQLCVSSFPFLKTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1R7</accession>
    <name>A0A914I1R7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GBF1-like tetratricopeptide repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1R7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6086.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6086.t2"/>
        <property type="gene ID" value="Gr19_v10_g6086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBF1-like tetratricopeptide repeats" evidence="2">
        <location>
            <begin position="760"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6086.t2"/>
        </source>
    </evidence>
    <sequence length="945" mass="104086" checksum="06A8A119BDB3CE4D" modified="2023-02-22" version="1">MTSTEMNYHSRLDASVSGNGFSAPVQLQQSRAVSPSVDEINSNSSPPPTQSLPFRMAANGVAGERNDTARHWQQWDSPEAMAVAFGENKKAQMAARAMFELVHQYGDNLREGWKNVLDCLLYMLKANLLPSPLVQLNDFVEPSGFALLKERFKRRLNVPRKEESGLLSWLGLTSGSGAGGGESGQSRPRSEEEKELSKLAASVVAECRPEQMVLDSRYLASSSLTELVNSIIHCSFTVAPILYALHGTHQQQLQEQHPAQQQQSQQESQDEDSFVDLSNVAVPPAESLQRVPMDSTDQQPLIRQAAAGSTFSIESTSSGDGRNSPQHLHNGHSNGPTVVKLSMEEEEAMVFLLELMTNIVLENRDRLAQVWSPVRDHLRTLLSHFPHNQQLVERAVIAIIRIANRNLFRLGQHPPAMALSSQPSSAVGSVQTQPSEMPTNLRRQKPSQGIPGQTKSVVIVVDPMDDQKQQRVEGTKAGPPLLATPGLTIQDRASNCADDVLHFMGCELLGLRPPELFLFSRQIAFGLHQLLRTNAANLHASEHWEMFLALLEAVGAAAYRDEVDGGEMVELPPPPPPNVRGAIFKRGTTGVLAPNLSRHDPAAFLKVCEILAFLARDAAHITPSNFMQFTRCLRIMVEASLDGGKCAPIKLPPVAYSSPQSPTNGNPSMNFSVPNSEQTKKNGSTEKQQQIEEGDRVNEQERLANCYMDACLQLLNICAQLHVRAATIHKEWSTADGVVATDRSPAPNQPQLRAVPTELWTVYWRPLLQAIARLSCDCRRQIRTQALDALGASFRVPAMGELMQPADWEDCFAEVLFPLLSKLLARNPPISPMDPIGMEEARIRAIQFTCKVLLGNLTQISRLDTFADLLSHLFDLMDQFLEESTCSDLLAEVIQESLKNCVLVCENFGIFHDNLAGLHGELQERLIALAKKHGNASAGPIKMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2I7</accession>
    <name>A0A914I2I7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2I7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6253.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6253.t1"/>
        <property type="gene ID" value="Gr19_v10_g6253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037434512" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6253.t1"/>
        </source>
    </evidence>
    <sequence length="1030" mass="115028" checksum="EC3FB59A0BA9DADC" modified="2023-02-22" version="1">MNQKILYLLVSIFTIVWATNLPKTPQEKDSGGPSRNQPKFNHSKQSAFHKVVPKSSKQSDKIKTNEVEADQSKQSDKIKTNEVEADQSKQSDKIETNEVEADQSKQSDKIETNEVEADQSKQSDKNETNEVEADQSKQSDKIETNEMEADQSKQSDKIETNEMEADQNQTDRMELSAKKSSHAQTSSNESSKRQPDKSGDEPNQSSEATLSVGENENEPGKRRRLANKQQMRQMDESIDGEGNEKMDAEMAGDAAPSDRRRKAVASTDRSINSEPPKNTENSPAPSMSHHQLESQIRQQSQQLIQLDQKMEKILRMLPEQQQRSQAQQQHHQQAQQEQQVHEPQQLPQPQSLQHSTWLQRYNRMLGGQSLQSSADAQQQSQVQNQQQAKMKNFLAQLKQHNQLQQPSQSQIQPTQLQSGSIQHSPQRQRQSPRSMAQHQLHPLASLPTPMPQLQVSSLSMPQLQGSSLSMPQQRASSSSMPLPLPQQRPSPSSSMPLPQQRPSSSSMPLLQQRPSSSSMPLPQQRPSSSSMPLLQQRPSSSSMPLLQQRPSSSSMPLPQQRPSSSSMPLPQQRPSSSSMPLPQQRTSSSSSMLQQQLTHQLHHSQTVHELVKQKQQELPIPPVVGGILESSANNSMQQPVDKGKQHSARVGAVGQLPTPTSAPSFALPGTSDQLLPVNLAVNEAGTSSNAEQTTVSLRKLYLMIVEAIVKRAAMKSISIIQLSLKNYGCVGHPALVGLNFVSPEHANKLAMAIDVVKVAETNTAQFVIDQMKKENADAQITQILEEIGEECADFERHMKARTANWEDAKNQQMLRENNFLLAFGRLYYKLFFLLTTAFGPNALQQESDVKKLLVWTDTMRKEIFKNLKNSEAQNPEVSKWCESLFQLEITNDLAKLAIKLTGYAAENNAMFNSFVVCKLTALLDTIVTRTNSLIPRQDMRETANLNNLVLISALFRKLIADFETANNDVIRLAKLREESKSAQNILELCLSLLDAKFNEFKKNALDTINALDVIRKGITEVDEGANAQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2L9</accession>
    <name>A0A914I2L9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2L9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6742.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6742.t1"/>
        <property type="gene ID" value="Gr19_v10_g6742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF241">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="327"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="779"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6742.t1"/>
        </source>
    </evidence>
    <sequence length="989" mass="110503" checksum="3500864BD07E69DF" modified="2023-02-22" version="1">MLVATKHANGLISSDEKTPPMCSAAEPQQHAAVLAPSSSSCTWQLPPSGALLADVDLEGGTLLSVEESEEIDPDDGCKVQVCQFHILSADQTEESTIIKRRKLKVNCTQSRKRFEYSNGKEREFEEKTILDNLTLLSSSDGVNENKIDPFENDASANDIQDVLLRTHDSFLLLLREKKDALIKMFPELFSNLRTMPAIFEMLPSTVMETIVNDDGSTTTRTKCSKAFSSHYTRHETFVNGIRKECTTRFRAFMEYAGPDGGFCIRLNDNADNDLSEDEGIELEEDTRSRISRSGLSEIPDTQSALVVTGKQGQPLLVDQTVAKRHEKAWHAVTEMVESEARYVQKLALLEKFRDLVERARVLDKRALAQMFANIASLHQFHEQHLLPQLMDRHREWQSSKKISDVWRKQAPFLKMYSEYTNNYKAATQMFDECMRRKRTFEELVKRAEQWDECEHLSLVSHLICPVQRVMRYQLLLKEYQRHLSPADPDWADTEAALALVLEAASHANEMMRKLDRYRSVQEVQELLGNNIALVTPARELLAKARLWKCSGGSGGTGSAKTEERWLFVFNDLLLLASERSALMRGGGAGKCKLRAIFAAKHTQICEGDNLEREYSFYLRGADSPQGPQRCVELCCASQAEKDALFDTVWTVIQQEVAAAHSQKCAVTTATEAAATLGKNSSEQQQQHQKCCARCDTDFGWYTRQYLCHRCQQRFCKRCFGGQRKCGGHKLCMDCLRTSEGYRSFSEGIPPTTAHGITPQTRRNLLQIPASSSGGTAEGSTIKASFVSFRGTSGGKQMQRFFVLRKNFCLYSYRTDKDNCALAMLPLSGCDIAIHQTEKFCLTIRHVNRIYWMTCFNESDHAEWMAALLLSANAKLPGERGEDSDDAAGAAAGMTEEGTTNDNNNNNNNNGTGTTIGDQKGTPPPISSTYFASRLKYPFSSSNPLISGLIRRSASMGDARIRQQGAAPAVRNTAEANGEGAAPEATSQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2M4</accession>
    <name>A0A914I2M4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaredoxin-related protein 5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Monothiol glutaredoxin-5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2M4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6746.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6746.t1"/>
        <property type="gene ID" value="Gr19_v10_g6746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="10">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6746.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31085" checksum="C7005739326141D3" modified="2023-02-22" version="1">MCDLLWSDPEESVGYGVSPRGAGYLFGSDVVKTFCEKNGIEMIARAHQLVMEGYKWHFNETEFWGRRALSVVSVERHTGGAAPSFKLKTGFQKEKHTHHSVCRVIRLMSLIFRSFQSTTRTAAQFAGLFLPASTRSVHGSQSLNALDTAARNRISDCVHSAPVVVFMKGTQQQPMCGFSRNVKLVLDLHHVPFRDFDVLEDEELRQGIKEFSEWPTIPQVYVNGKFIGGSDIVVQMHKDGEMAKFLDEEGIPSRFSDKFEPPNGGGGEDGAGAAGGGEQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2M6</accession>
    <name>A0A914I2M6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914I2M6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6282.t3">
        <property type="protein sequence ID" value="Gr19_v10_g6282.t3"/>
        <property type="gene ID" value="Gr19_v10_g6282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase central" evidence="11">
        <location>
            <begin position="878"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6282.t3"/>
        </source>
    </evidence>
    <sequence length="1176" mass="136717" checksum="173E53042A2C91DC" modified="2023-02-22" version="1">MHCKKYTNVDCQKALQIQLCWWRRTNVVGQFLFGIFFGRNGRIAQNACKMEQNREELERIFIKKERNPEGTEKKNGNKISTIYKQFSSELTDIIQSALEKADELSLCHLLRLKSELFKQMRLKIFGHSMKRPNCENTAVATQTIVENREQITEWMLSDLLHFFPHRHRTIKYFRQVSTRNVIDEMHRTWRKLTELVGIRGALMLHLVFYDKLCVIGPSGQNVFTLMYEEYFEKYELHNGNKNAELKMKTNFLYGLIEDCRSYQESFWHLEKMIRESIDFNNKINKFGNIMQIIADVQDMESGGCGMTNSTMMLWEDAPDNNGTLLYHSLTICIKKAVSGYSDKFLITALDKLKALEEKTKQQMLKCVSRLAKQQQQGQRRDELLGKLHFDKIVRLIEDDAVSGLFGKVLSEQKELLHELMNSDEIAKLVNLYEKNNNYFSTSEDIISSDEDNFYEAIKEDFKTENYDKKYKKKLPNVEEKNVANNCSINLTKTPGVKAVESERNAGDVKAKPQKSTKTLPKYGKNEMATNSQKSTKTLLKYVKNEEMIYTNDCTILLRKLGIHKFKDTFNDQLIESLYRMHFEVFIRAIHAKLEFIKFCNEIHEDNNFEQFQETWTNFEDTELNKFGDTQFVLDKLFFVLNELDQFAFYASKNKCFFLKKMLTMQNLDATLFLKYNQAPLIYERFQSDIIRSGREIRAKQLERSTKMYQFISLHAIKSDKYIAIANLRKRINNIVTMWAAKHLKKSNARLVTSGSHSLYAELEGSDLDLLCFLPNNINVYKFYGSDGDSLVSMLKNLLDAKKIDWISGKVKLIKIEHIDMNIDLSLVPIPGHYLVQKNRCLESDEIVKETQFESAIYSLAGLRTAKYLVLNVPNQQMFSSLLKAVKIWARNRLIYSGIFGYLNGAALSVMAAKICIVHPNAPINYLFQQFFMVFSKWDWPHVPVLLEELSPSSLNKLVRFWPPKFAENSMTVITPKFPEQNATFNVNTFTLDTIAEQLNIANQILSKNGKNWPSVFEVFKYREHFGHFAIIVCSTLLHDAYSKHCGYQITKIRQNLLKWANLAEVAKRLKTYHIIPQFEQKMLCNNLHLKKAVFCTLWLVGLTAKDEFNGNLGDDLLPIYQQFNKNLGGNLLPPNQHDHKMGIDEVFIQAVFSDLENLDTNIDNLLYKSNTSKNEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2P9</accession>
    <name>A0A914I2P9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I2P9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6294.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6294.t1"/>
        <property type="gene ID" value="Gr19_v10_g6294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036903234" evidence="5">
        <location>
            <begin position="21"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6294.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="26054" checksum="247AC9EF1C2F84A0" modified="2023-02-22" version="1">MNKCLLLLLSSTIILQFGNSTPVNSKNKDKENETENTAEYSSSGHQIGRKNTGKIKNSGSKAKHFLKQVLERFAEKPKVYEEFLDIMDSFGKHRYTADEVYQRVSGLFRDEPDLLRIFSFFMPDKKMDFEDAVRYLKRVKDTYADKPDVYQQFLGLLNDYKNRDLTIVELYKRIHRLFEKEVGLRGDFAYFMPVDRTNEQLLDKLLKKKQQNLQLAEDLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3H4</accession>
    <name>A0A914I3H4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3H4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6970.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6970.t2"/>
        <property type="gene ID" value="Gr19_v10_g6970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037850798" evidence="3">
        <location>
            <begin position="33"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6970.t2"/>
        </source>
    </evidence>
    <sequence length="605" mass="66429" checksum="4FEAE330EC014BED" modified="2023-02-22" version="1">MCRRPLPTAAVQLLLFCFFSALLLLLPSQGNALTCGYGKRSESEVFQERIQEECSPTQIACYLASCSSGEKEFFAWGCTLVISEEGSNCKSLVTADVTEDYPSEHEWTCDCTFGELGESVDLAPPDLTSTTTTTTTTTTTTTTTTKRSRTTKSGGGEKSGGGRLFVKTHYLLFALQMFIGIVPAIIQSKKDHLAAAFGLLWPKLSQLNCNSLITNGTKFKQFSCVKRRRIVQMDPPHGHLDTNCTAIRARWHFVETAGTAREANFPLAFAQTVFRCSGVGLLLVNLRNFLPRPAERIFCNYYFEVLNGCAIAINGTMLHGEQSSDCNGWNKKDNGGRGDDGMAETPGEQKTMLEDHAQRDGQQCQAVVEAPLLEVPFGGEKNVNDDGLTDDYGINNHSNKHNSWHGTAFTEVSFRGEEHVQMIVYDDGLTYGINNKSRHCTAFTEDALSVTSCPGAISLFFLGIFYGWLIFAETLRFGVRRFYAANVFCALLSLSLGAARFKQMDSELDSAKTTTADGGTWWIWATAVLLLLLLLLLVGGGLAFVVWKKRRQSAPTVPAITVEVPADENEIEMTEMAAAPTRRWEAYPGAWNTATGSFKGGQALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4Y0</accession>
    <name>A0A914I4Y0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4Y0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7558.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7558.t1"/>
        <property type="gene ID" value="Gr19_v10_g7558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7558.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35459" checksum="6EC213E26B2A55BE" modified="2023-02-22" version="1">MDCVKLFVRWTAYSSPPSATPTSSQTLNHSHDHPQPLLISDEPSPPIAHQRVKRQGSTVLTKAWSEALPGVPPFWDKYSSGPYGIVIRGWQFSRCASEQWTNYVVNVSNIVIWPDYPRFPGPIFFNVTMDVNEDLPVEKIEMDLEVRHAVTGKHNSKGWQVIPCQGWNLLDGCDGVGSCRYCDVLDKCKETVKGAHKYVNDRKAEEFLRQNKLCPPPKGHWTMTFSKIFSIEDLPKSFFGPLQSNEYWLTFSFTDGKDKKLGCARLWVDVCKYHLQDKQQKCLRDPNAFKNFINEISSQAEQIRQRTNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5N5</accession>
    <name>A0A914I5N5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5N5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7128.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7128.t1"/>
        <property type="gene ID" value="Gr19_v10_g7128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7128.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27947" checksum="BFBEED1B33A132E2" modified="2023-02-22" version="1">MSPPVIMSPFLRSSTLFSSSDNPASSTSFRPSFIVSLPLNSRRQYIRKCHRTECSEGNYDFLWSFKNVINWRRAPPIAEREASYQGKVLSDIGKWALLPRLDIHADGPIPLNLVPKYAHKTRLNGIRQWRFAVLLLLDKERFPNGGFGRARDQFCENLSSPAQLNFLRYATGADSVHIYRLNQAFNCAPPEDYDVLYLFYPRSIRLIRLSMHLNITLDIVRNALNEFPTFYVPEAESSDDTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6H0</accession>
    <name>A0A914I6H0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6H0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7202.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7202.t1"/>
        <property type="gene ID" value="Gr19_v10_g7202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="145"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7202.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45705" checksum="942022E3B2D4D2E3" modified="2023-02-22" version="1">MSAEETAKLKRNSRRTAPTSCSVSRTPKKAPPSVVLAMEEDVGEEGGCPPATTISSRATGAVAERLVRRRGSNSVGRRHVQPPQQPAQHEFENGKISGGTKEGVGVALKLKLMDSEAERHRNEKILSCPELVTRIGDRSVFYKMFELGSQIGQGNFSDVFLVFNAEKGEKYAVKEIDKGRMNGKLHFVENEIALLQRCPHRNICRLVDAFECRRMYFLLFDYAQKGDLFETIRRVGRLSERSCAQITRQIASALAFLHRRRIVHRDVKPENILLTADSTAKLTDFGLACILVGPLYRVCGTPTYVAPEILTQQGYGVEVDVWSLGIILHICLVGFAPFHCTDRAQLFQQIVHGKITFEHANWSLIATKAKKLLLGMLTAAPKRMDAEQVTRNEWIVAMTTQNADEPAGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6X7</accession>
    <name>A0A914I6X7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6X7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7318.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7318.t1"/>
        <property type="gene ID" value="Gr19_v10_g7318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000003">
        <property type="entry name" value="Class V chitinase CHIT5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF400">
        <property type="entry name" value="ENDOCHITINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="155"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="623"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7318.t1"/>
        </source>
    </evidence>
    <sequence length="918" mass="102599" checksum="593296F68E3EDA4D" modified="2023-02-22" version="1">MVNGSTGGRADGSVPSTDGTGADGSVPSTDGTGADGSVPSTDGTGADGSVPSTDGTGVDGSVPSTDGTGADGSVPSTDGTGADGSVPHNRPNDFFVLFLKLTQLDFDRASIYFCVLSLTDQPISYLLIFTSLFVQMSPKVTSNILLIFVAATTIFLLEVNVNSAEEGQAKFEPEKYVPGLCTHIFYAFGWMNEDFTAKAYDPSDVANPPAQPRGYYERFTALKEYDPGLKAVLSFGGRSFPNKVFQAMISSAENRHTFISTAISWVRRFDFDGIDIDWDNPEGDKENYDIFLKAAIEESRVGWARLLITIEVEGKRQIVDRSYNIAGIAEFVDYVLVKGFDFQFDESLEPKTGFNAPLFGPKNESDENKKHWNVADAVNYWISGGMPPAKIVIGIPIFGRGWTLKDSKQRKIAAGTPGSAAKPQRYSKSAGAAAYYEICVMLASSKTQHFFDEETNSSYLITNGNQWFSYEDQQSIRLKLDWLRQNGLAGTYVWALDYDDFNELCPNSKSDGAYPLIGTIARELGNVKKLGLPVEKLSKKKNNCPSAEDFEGHFCLSNYLFTIFAGIFLLMAISASFSCFFIFLLFKLRRSRFSYGSSGFFMDIKAHLYFNPMRVHELDPTVIDIEKLIYSGPNSRVYFGRYRFAEAEFRRVVVKVPSKDAFRVQSIVGETRINAQLRHPRVVEYVGFYRDAFGDVRIVSEFMAGGDLHSFLVDKQNIITVGHLFNFLRQICEGMEYLISKHIVHRDLASRNCMLNGEGTEIKICDFGLSRHFGTDTTYSCTSPVLLPLRWVAIECFDEDGEIFRNCKFSEKTDVWAFGVLIWECFSRGAQPYGEMDFREVLPLLKGHKEKRWRLPRPCACPVQIYDNLMQKCWDGRPDGRPSFADVRELLEGILDQITFEMPDLMVQIVAPLFVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6Y7</accession>
    <name>A0A914I6Y7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6Y7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7326.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7326.t1"/>
        <property type="gene ID" value="Gr19_v10_g7326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7326.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="39420" checksum="6252DB49958CB5C9" modified="2023-02-22" version="1">MTFNRLMDHCEATNRNRDFDGVTHSGHQSPLSVWQAFFTQKRPATKRWRRAIRFRRPPPHPQPPPPPPPHPHPQPHGGGGGGAQLMPSWTDPPPPPPEWNNVFAVTVLRAVHLHPQPPPPPPPPPQPQPQPHGGGGGGAQLIASFTEPPHPPPHPQPPPPPPPPPHPQPQPHGGGGGGAQLIASFTEPPHPPPHPQPPPPPPPPPHPQPQPHGGGGGGAQPISSFTAPPPHPQPPPPPPPPPQPPPHPQPQPHGGGGGGGLAQLMPSWTEPPHPQPPPPPPPPPPPQPQPHGGGGGGAQPTASCTAPPPQPQPPPSPWRRLRRALGATLKGQRLLSQRFLSNLLKSREEGLCHGGSEQNKQYTPGWGDHCVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I757</accession>
    <name>A0A914I757_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bladder cancer-associated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms. Modulates expression of genes involved in the regulation of proliferation, cell cycle and apoptosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BLCAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I757"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7246.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7246.t2"/>
        <property type="gene ID" value="Gr19_v10_g7246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7246.t2"/>
        </source>
    </evidence>
    <sequence length="234" mass="26294" checksum="EDA00001F421B6BB" modified="2023-02-22" version="1">MRIVQLHKKPQPCPVSSSECLADLCMSYLYASIVRIGPSRQRDGKAGRGEEVGQAAPIAATHQLQIDRSPIDSTTPFHSLTVTRREFLTNSSTFYQSGQGKVAEQGLSRNACGSLPKPASQYFLVLLALVVTEYCSKSPSSSCQKWLMPVLLIPKQMVHPTFLIDQALFLWFYIIGFVLERRPCYICLLLFSMTVLAICYSDEERCVLWPMCETVLNGEMCKSVYESEQQKMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7X3</accession>
    <name>A0A914I7X3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7X3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8111.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8111.t2"/>
        <property type="gene ID" value="Gr19_v10_g8111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8111.t2"/>
        </source>
    </evidence>
    <sequence length="629" mass="69397" checksum="C7B9249A24DA6DAE" modified="2023-02-22" version="1">MINRTIFVLLAMVGGRAKRAQRSAEGGKSVICAHQIIKPTNSLKVEIGEHFTHRWSCSEEYGPNRYVLFVRNCEQIERNGKRIILTDKFGCPSEGVPAGHFSLNYSDSTRHNANNSSLLTVFGHSQLFSSPVGSLFRIECILLLVPKVGGANATELPNCSRNSSTAGRENVLSKLLTPTMANQKRFIDMVETSVSSQWIRVGDGHKDRPALSKHFGTFLEKLSSGSKEHREEAPNMALNPFLERAYSIFATSVPTVPSIPPTAITAPPTRSTVPNAEPVTPTAPATVPPMAQFTPSTVSDTEGAIPSSSPKEPATPSFSSSLPLIGIRRDGSSSSPPNLGNLNTPSENKHPKFESHHYVRQQNEQISQETSQNSFYVNVSCPFFHNASTPSPSRHCSWSMLNTALLTWSIFSTLHWLCLLGGKLRSSVIVHRRLTISPKQKMAAAKMNAMRRKMMRTKHCGGFKHRKSLIECPDNGTTDRKSPSERRRAQQKALRTVRQRHLLHRTVIGAMPPLGFDQPESVHQLSLSAATHRRQNQINDRRRRMVSNLGRIQEEEGEGKRGCHRQEKSGAGILDGRSEGRAKSGGGRAVDDGRAENGEQIAVEQITTPSIGNALQMITARHFRSCFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8I8</accession>
    <name>A0A914I8I8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7888.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7888.t1"/>
        <property type="gene ID" value="Gr19_v10_g7888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="660"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1390"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="5">
        <location>
            <begin position="1725"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7888.t1"/>
        </source>
    </evidence>
    <sequence length="1923" mass="217046" checksum="95563448F151D84E" modified="2023-02-22" version="1">MVTKERKQREAKRVQKEKCRKQSNASLTTEGRPSTHAIHQPSTETGTLLFHAGTSRQNDDCGDVVESAVTFAGVDQCARRSICGDNDSGDESIIEALSVASVGESERLDRGVSLASKKMARNTSISSGDVTLRCRSARLVKLQERHVHQIEETMKKVLNDYINRPWPTEARQKKQKRRSSDTPNCTRCGDECDCTSYAQCQQNAAAFLAAGKYAKEYNPATESAPKFEEIARAKGGRVTQRCHQNKDLKCASKSASHRVDYYDSGQFGEAVCEHCGALMLKGENEKIKGGRLSQCCAGGDVHTQQMKAEFEELQTPPAEYSKGLINSNDQKTREAFLDNTMPFNNTFAFASVRGEKAPEDQMGGRLDTCKYNGEFCFQFSDLIAPGGRRPTFAQVYTLTPEAAMNIRDENLTTALSAPVKAEIVRKLEELMRANPFGRTFETAGAKIEAAKSATGEIPRFQIALLTDRDLKTDALKNRGDVTIIERADAPTAKQVAVIWVQEDGLAPEISAFWVCDKAGKMRELESGMPQLDPCCFPLLHPRGTPGWRWFIKKRGRMVNLFTPTVHTANKQLTREEREEVQMQDALDNSMAEEVAEPMPNEPDAGASDHREDDEMPEEALELDEEVPEEEENTAGREADAVMEPEIDGSTKKSNISERQFYRYRMALRGDDKSAFHWLWFARRLAEYFTISVLNRIERNDMDHLKAIQTKKNYRQILARDYIAAMEKGLQKWGRNAKLGRVFLMPQSFAGSRQYYQGKYADLMTMVRHLGAPTWFVTFTGNPKWPEIAEALRRRQNYAHRPDIVCRIFMDKATEFIKDLTERHVLGKVAGWCYSVEHQKRGMPHIHMLLILDKGGRIISPEQVDEYVSARIPTLPPIDDHSPEANQQRRLWHNVTTMMLHDCNAACLEGSNCRKHFPKPYSDRTELSEVRYTNYVRLPPEDSDQWVAPTCGDARVPSGEDHLPADDPERDWAEVRYQRIPHKGRNPQRQHEECGRTFYKQRKGGRSALLLDDSRVIPYNNFLLLKYGTHINIEYVFGQKACKYIFKYLLKGFEKAYVQVTQPRKSARRQSGDATEDVYDYDEIAATFKVRYMTAMEAYLRLHSYKIVGTSHQIYTLSVHDEGGHTIVVEEGQEQEGHWKVDANTRLTAFFKLCGDDPTAALLTYDRVPYQYSWNYKAREWKKRGRPLSEDIEKARMFVRVYTVSPRKHELFAIRLLLLHRPGPKSFEDLRTIDGVVFSTFAGAAQHLGLLESDLIFRRSMREACAEKSNFKQLQHYFAMLLCHARPAEPQELFDEFLDEMNPPFAANNPAIRPKSVAFRGAEVMRNLEYFFNCMGTTSGDVGLSGLPNDYNFDRQAGALQQATLLDEFYGDQQGRAKSPQQIAIEKIGLLNKDQRNAFNDISSAIRSADGQRLFFLEGSGGCGKTFLYNTLIKWCLAGKPTFNSTTNQERGRENPLCTSSVIAAASTGIAALLLIGGGTAHRQFSVPNDVTDDTAPTISFESSKGEQLRGADLIIIDEISMLSSRVLKYIDRLLRDVCAVNDKPFGGKVVVCGGDWKQLTPVVEHGTREDQVAESIKTFPLFKTFQKISLTINMRTAPGEQALRDWLHNIGNGLHQVGTDIGSRQPNLLRIPPQNVAHQMDDVINFCFPEALFSEPLSNADAIASNAVLCPTNNDVQHINDLALDRMSGDAKEYLSIDEPLEPSDEFNTFRADFNMEAVHSEMPSGMPPHKLILKVGTPVMLIRNLDVSQGLCNGTRLQVMRGADDNLFCRILTGPRADAKQTIVIPRVKFEYGNNRNHRGLRFRRLQFPVRLCFAMTVNKAQGQTLQRMALVLRGKQCFAHGQVYVAMSRVTRMDAIRVYAPSCQSGDDTRIANVVYHELLDDINVPPRPQHSELAVAVHDQGVGTLNADEDMESLDEEYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8K6</accession>
    <name>A0A914I8K6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8K6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8487.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8487.t1"/>
        <property type="gene ID" value="Gr19_v10_g8487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8487.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32141" checksum="1E4EC14639FB92CA" modified="2023-02-22" version="1">MPATRLTARCSSLHRQTIQSLCTTATAAPKQRSVNSKKYGVDLIHFAHTKTDAIHASTKIDHTIRYLSLYDNKYLRYFQGHTKKVVTLCMSPLDDLFLSGSQDKTIRLWDLKSSNCQGLMQLVSRPIAAFDPEGLIFGAGIGNDVIKLYDLRSFDKGPFNTFKINDTGLGCNWTGMKFSPDGKSILIMTDGNVLRLVDAYFGNVTHTLTHDNPKNVNFVAAFSPDGKYIFCGSGNGRIICWSAESGRKINEFPTSHTGNIEQVAFNPKFFMVASACTQLKFWIPSVDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA33</accession>
    <name>A0A914IA33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8080.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8080.t1"/>
        <property type="gene ID" value="Gr19_v10_g8080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612:SF0">
        <property type="entry name" value="CHLOROPLAST PROTEIN-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037610497" evidence="5">
        <location>
            <begin position="19"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="SecA family profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="63"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8080.t1"/>
        </source>
    </evidence>
    <sequence length="625" mass="70784" checksum="8968717AD71C39A7" modified="2023-02-22" version="1">MQLHNIFVAYLCLIKGTAQLILNKRDLDKDLVNQNVDNQPQLEAMNPIIVNDQHIWIDKICENISVQVTMCKRAALIICLNNAKVKQLSTVVESKCRDIKILKYTDDDEHFPTEFVGPMDVVLSTNYAARGTDIKTSAELEAKGGLHVIVTFMPRNSRVERQAFGRTARQGKKGTVQFILNGCDMDEELFDQNMDILAKRDKLVEQTFEKSKNEGLPKLLVKERLFKKFSTFIGEMRESTANAVGGNVVILAQKLLASRKSGNARGSNAFRLDAFLSSFAPPFLGLSSFTNPCYLVLKGYGLDYGNAIAHLEKAIELDKNESGFVVPARYYMALALVKKGDYFSVEDRKVRTEYQKEAAEHLKKANKLINNKLIPWLSKGVKPNGEGTAQNMALCQQFVDKVQLLRQLSAQCDKCLDFIAKCPAGQFCKFKGWIKPDPDKKLPQREVTEFGNFGVWEFYELEYAKPPKAWADIGVITFFGAVQIGCGMFFVYIGAQKLAETFLEGGFNDIAEAIKATFGYTVISWDKYAIDKLLTYCPLFTDGLKQLLSGKAGMSMRDLNKIEWMLHQGIKVLSGEKPDGPIQHELKNMECYDKAKEDIPKPFNFNRRSRNVWLRQRFYEECRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAY2</accession>
    <name>A0A914IAY2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAY2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8219.t3">
        <property type="protein sequence ID" value="Gr19_v10_g8219.t3"/>
        <property type="gene ID" value="Gr19_v10_g8219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8219.t3"/>
        </source>
    </evidence>
    <sequence length="908" mass="101745" checksum="76E71553EFFEF910" modified="2023-02-22" version="1">MLQTPPSFGTDTGTAHKNLDSNIMHVNSEVHIRKNSHKTIPTPPRRSQTTTPIAEHRTHRHDEMSKSERILNSLIEDVHHRASVGLATVRLNAREVCSGESNAENDEENMKKFKRHKKEKKRKKKKEHKSKKKDHRSPKQHKERNEEKRIKRKNRKHSKSEEHETDVGYNRSEQIGFGETKKDRSRAVFIDEDELPVGADFQLFGHDKGSWATNSGKECFLVKKNALKIRRNECDDDSKSDSEENQKTLSEKQSDASFPLKKQSTLANILASAPQSFPWLTALGKQKQSEKDFGGETERNEKKVEGKAEHSEKKEVGGVTEHSEKEIGVKTKQPDNEKGVGEEKEQSEKKGKAKADKRIKRKSRHHRSSRRRHHSNRSRSQTYSASPERSHCHEKARHHRTDKPSVSPSPLPAFSRHRALDTRRKLIEESWHRRIEHSIRPCEMPKKRRSSNDTAGGNELIKSDYMDENGRIDKQKLLDIATRNATRLAMEGKLPKGAELTETIKNKSVDQLVDLCKKLQSDRSLVLKQHGRGGSSCSDLDDDGEYSRKYERWRRERERREDKEFQNRAVRPAGEPARISCREQREIVRHEENTLRLTYPVSSGVQHRTKANMPVSKESSAGALVRFGDIGPLTTALAKVRTNILTAYKPLSKPLALSQPSSTLSSNSQNTSQVEIGPQLPSISQCQSNKPLFPGFVPAKTLDCVNANAYEIALAASARKKEAENSDKTTASNEPMTATSAQFIGPVVPNSAVDAVLNASLLLCSESASNSNCPSSSIASPSTIPKPVFSSSWDRPGHIAAREAFLRKVAEQKRKTEESAKVADTQLRQQSKIVPSTSSQISENTSQNLAPSSCSHLSASSFSLASPTPEFESIQPSTAQCHEAPANSIIEPKTNADGFFKKVGNRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICD5</accession>
    <name>A0A914ICD5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor AP-2 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICD5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9313.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9313.t2"/>
        <property type="gene ID" value="Gr19_v10_g9313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="184"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9313.t2"/>
        </source>
    </evidence>
    <sequence length="407" mass="45288" checksum="D807B8D2F3871294" modified="2023-02-22" version="1">MSDHLVKRKPDCASEEEVYGAEEETPPKNVAKHREQLQQFRFEEISSCTSATGFSQSDLLCPSNAVCGSTTVFADAGTAEYALDVQGYMAQHHTFISSAYTHPLNYYQLIDNGINQSRESVGDQFHSAEQLLAFNRELQQQQNANDGKEKCTPNNGVALPAPSMNFGHNQLNQLLHNRSPFEPFCTVPGRMSLLSSTTKYKVSIGEIQRRINPPECLNASLVGGILRKAKSKDGGKALRESLKRIGLSLPAGRRKSACVTAFTALVEEEAIHMANDFHAVLQHDFPSKDIGFFLNSQFLRFSGQSSMDPELLARRRTILNCSRIFIKELTNLLAADRSPICDRRPELVLEPAIQKQLTHFSMITHGFGGIAMLSLLEALHTCLDESLKSLDKLLESRIVQQQTCNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICW4</accession>
    <name>A0A914ICW4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICW4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9443.t4">
        <property type="protein sequence ID" value="Gr19_v10_g9443.t4"/>
        <property type="gene ID" value="Gr19_v10_g9443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9443.t4"/>
        </source>
    </evidence>
    <sequence length="291" mass="33355" checksum="58492C4303BA0BD3" modified="2023-02-22" version="1">MKPCFDKFTNFVKKWINCVNENLIKDKSCLPHKKDYVDKRMNYLFGMAENVVIPSGSVKIRQGSKFCDMKFSRKLQRFLPIMASSDGSTNKIPSGAIPNRFSYENQLKIMLENQKNYKRINAKISFTIYRKKQINFPDDIYSFFALRAAIKKIKTLKSKNQNEAEYVLQIVTAMRDSIKEINSYANKTASTAIVNEQLRFIGLVLGHLLFRENPIFNVANNEFSFTARIEPDIDAVNLSACGMLVIQFDEELKAQLNGENLLREDSLNLASRKNGSTKTNSSVQGFVKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDD0</accession>
    <name>A0A914IDD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9179.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9179.t1"/>
        <property type="gene ID" value="Gr19_v10_g9179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664:SF8">
        <property type="entry name" value="DUF4440 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664">
        <property type="entry name" value="PROTEIN CBG16427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="289"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9179.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46930" checksum="A2337C11E505B447" modified="2023-02-22" version="1">MDKSEAVQLEELPLPTFDELFVDEWWDKDEAENLKTPPTIFGKNVHHQIDRQNTQLGQIEPNSTDQNLPLTEFDHFRQFESNSTNQNPPLTESDHFGQIEPNSTDQNLPLTEFDHSENTKNGEELIAEDERKQKFDQMKAELKRAGFKNSQNELDKTVAKELGLSDRTIYKWKRELGQTTPQHNHKELMIRYYEIKGNKIHDKDIAKSLNISRFTLYRVKDTFKSFKFHNIFKQYSSKKIKTPTIQKSCQKHKQNIIFALHSYRRTLQRQSQSGGRPIIRMSLFQEIKGRQEEFMRAFNAANAKGAAEIYDPDGYFMPNGHSPVKGRSGIEKFFQKDMADGVTSAQIITEEVNGSGDWAFERGSYHLECARGTESGAYLQVWKKINGAWLIHNDCFNVIQSARQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDS9</accession>
    <name>A0A914IDS9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g8964.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8964.t1"/>
        <property type="gene ID" value="Gr19_v10_g8964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1499"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1511"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8964.t1"/>
        </source>
    </evidence>
    <sequence length="1521" mass="174846" checksum="98051ECC0AB44278" modified="2023-02-22" version="1">MFRVWCRLPNPDRMKSEWPTAQLDNDWDRTTVQFARDNGIPLDADGRLDMEKIVRKEMVTEMADKFGILECTIRPISAVRNEKLESDSSKMNSSRSINNIYRKSRINISDQESAAATQFESSSKTETSGSKNYKEEISRKYGRRATRKFIEQSSDHSDRQELETFHRKRTSRRGETPTKHYDNKTSASGSKSSKYVTAGDEQQSSDEFYQRQKPAHQTSRRKFGNKTPKKYGTEESSSSFATSSDSSVERQRAHSLPKKHRGNITKKMKEAAAIPPAPPAIGSYETTDTFVPPFLPNSVVDSSSIPAINCEKSEHLNDFVRILYSFRLKNSKVLRKTGPNQLVFNLSHLLTNDSEWDAIERPLDDVQLGLAQENLFSTKMGKRGHVTLDMVDFITNAHVRLVAMKTPQIRCTIVDERRQESSLVNETSSNRRPNSEEKSLTTSGGSSSSSTELDETPKASSKHIETDQSLKSSTLLSTNRTLTVDDLTEGKSDGDEDEIWYSFGTKHRYMKVLKKNEQIGINLYRFLTDESTWDELEVPLNRAQKRLAKRAQFELRQNKRGQYTLNISEIVYKFAQITLHVEDFVCHVSVPKEERLVVADGKSKNGSTKSDHLSMVEFLDSVPINCEGNLPLLNAFVKIWLSMNVAHKCIGKMGDELVIIELYELVFGDQQRWDKLEKALDTAQINFANSNLIPLTIRADGGKVLDMAKIAKNKNVTELALKTNKISCRIGNIPVLDSAPHSRTNKECPEELKENKKQNLDHATNGNENAENISPMTPKKSKFIESLDCQIAHDLMKNWSKISKIAEILKWNGLRDVLLSLRQRKSAMVNAWRRVNEFRNCELMDDLVQRAVEAFEAVDKFLDALKLIEIGENLKEEFEKLDGDGETELNQEVVQLTNNPEWELAEFTNYEMNQLFNRQTSLVIVSLNAVEEAKIMLSAMRKAVSENKHEIQGGIWDQSQNRKFELPKAIYDYVKEKNVNGATGRLLAFLDELYRVNQFDSIKKFVDQIDVYRDDPREEVHELWRKFTQGIDWVQRLNYGRKLVQFVLYLHRLVPKYSEMNALKETTKMEQSAQHQPSLVTGKETMDEVHSHAKEKGTAAGTSGLKGFKNLELETIYRKIKQQMFDQFQVWWKKVPEQKEPLYEFYKQLDDISTRYVLSIVDAFFDGIPIENFRNEYSLGIKDFKIAKERGRAEAESSENDLYSIPSVAVYKSELPDKLSNHNSGRFNQHNFLTKFDDKSSKNMQITAFITKGLGSVFNWSKRFINELVAVTGNDFDELSPLYFYEVSSKIDSNGKKKKLRKPLPPVLNKNKLATIVKVIKLYEQKFNNKNISQMSDQKILEVHWRVMRQKWEAAAVGRQRARESLSRTSSTAEDTLQMLVINAEVQMNEQERKESLDKIEALVRSKRLLMFAIVLRRKYAKVEAEDAKAATSFGTIDTAYFEALRDIRREVERWVPRRREMKRLYRVCRQLNRAERIEISKLIDAFLNGKSVDKYLQKRQKKSGQSVEGKGAKNDVEVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEL0</accession>
    <name>A0A914IEL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9502.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9502.t1"/>
        <property type="gene ID" value="Gr19_v10_g9502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9502.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25719" checksum="D9B1E13683670B7F" modified="2023-02-22" version="1">MSDNASEVEQQQQMKEIDRLDRLVDVHFKSRKWSFGWLKIIRATDVNGAQIYTNALVNGSQLLKNRFQANFIDQTVIEFLQRICRLFNSPGKTIEIYTPDDQSRSWEIICQQIWPLINDNIYNFCLISDHARLQQLSSVILCNCAKLELIGAYGRLLNCRPKTTPAFVNAYEPANFIIRTNLGATEPFELKNNLMGERLTLRQIDEDFWLMLNAKAGPSATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IES1</accession>
    <name>A0A914IES1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IES1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9237.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9237.t1"/>
        <property type="gene ID" value="Gr19_v10_g9237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9237.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15771" checksum="9AACF4F07C4B8716" modified="2023-02-22" version="1">MGRPGSSVGRAAHGLVKDVGSSPPGANILSENEGELNSKGRVYVVVQVQRYQATIAPVGGRRVTWPHFVSIRDDLPSARTERPLQVGDLLELKQFDWREGFRFLLNVEDGVDITAWLNNGQIKAQAVAKEVSLLELKLSQQPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPA7</accession>
    <name>A0A914GPA7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPA7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10170.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10170.t1"/>
        <property type="gene ID" value="Gr19_v10_g10170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10170.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="26329" checksum="F45F5A3A0AF36972" modified="2023-02-22" version="1">MNSSSKQASSSSNLICRSSNRRRALASSAARPAPSSTLQTVDDVISRSSSSVSSSRMMKKSTSLQLIFVVGLLLHCSVSMSSGRLVGHHHSQHFQQLLDSNTEVISMLDGDVLLEPSSIKTTDSDDAICAKSSDRQATIVRSMSKTTGQPVLLLPQQHFKVAYCEPQQSTTGNGGSGESESCATGSNCATIYRWAKAKVHPPKGVTQFLNFGTKFEIGDDVLVPMDCLCVLSWAQTFRGKGPIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQH9</accession>
    <name>A0A914GQH9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQH9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10243.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10243.t1"/>
        <property type="gene ID" value="Gr19_v10_g10243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10243.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="35007" checksum="79D45543A471F91F" modified="2023-02-22" version="1">MSDHPSVQQRHLKEIQVCDDVCRTIFGFIGPADLGLKLALVCYRFDVLVDSHLKSRRWTLGSLEIRRKSNGTGAELVKWEDDGTATKLPFAQGLPPDGGIITGFKRLSIRYVDDIVVEFLRRFRRHQFDWPLLNDGFRSSGYFNTKLIAQLRRQIATTVLCDCINLRSIYLTDRLFPEYPADDREGTTAGQALCKWLHTPLENGQPKLFRTHCWDTMTMQPLFNQLKNKFNGLHSRQLFHRFSCLDWHMRCPIARDEEKWAKWEREAVEEVDVGRWEHFVYMDFADKDIGPLSVAGLKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQU2</accession>
    <name>A0A914GQU2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GQU2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10338.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10338.t1"/>
        <property type="gene ID" value="Gr19_v10_g10338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12889">
        <property type="entry name" value="SPRY_PRY_TRIM67_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000178">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="14">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="COS" evidence="17">
        <location>
            <begin position="515"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="596"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="15">
        <location>
            <begin position="698"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="897"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="701"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="997"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1177"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10338.t1"/>
        </source>
    </evidence>
    <sequence length="1197" mass="129685" checksum="F440EB95A4CB5275" modified="2023-02-22" version="1">MESIRISSRFKCNNYRRILRCDDGRTDLISGGSFALLAAMFSPRLLKNHSSDGWDDDDLIREEIPMLSSRIADGWTADEVTTTDGGRKTEDERIRCFVHGRGVKVPALPSCPLPAAAEAVPSVPSSASASPSSSSSSSSAISSGASDTLSLAPSCDESAADSATTNNNEDSRSLLSDSADSGVGGAFRGGSRPSSFLSTTATVPRPAAVLLPPPPAASILSPSSSAAVASVVLHCEACQKPAYFADEDVLRTQPENVAVSRLIARQQQRAEAVAGSDGADEATTTVPDCQWCEGPNGAQPAKFRCNACGYFYCADCQLVLHPPRGPLKTHQLISADEFNKRSSSISREFVFPVSSPSPCSSSDPMPSSSCEVHPDKELALYCALCQQSLCAQCAVDVRHQNHHVQSLQVAAKSHKTELSQSLQLLSAKVRQATEDIASLKQLQNEIDANCDVFGRSIEREMDELIALLQLRRQQLIDFAAGERERRKAQLREQIGRSTAQLGRNRALIQFCIEILKESDPMAYLQVGNALASRVTDQEFLWHREIRTKSEVDVQFEYDLDSTPARTALEQLEFLQLKEEGIGEALQTEEEAKGRGAPPAPQFAADECSAENNSITLSWLCPQNGVLIDGFVLELDSGRGQGVFREVYCGPECVCSIDGLHFNALYNARVKAFNGSGESAYSELICLQTASVAWFQLSSEGPLHSSSSERNSDDVPIAGGHSPSPSAGGGDLLFSNDCCTVTGTSIDYRTVLGTVTFSQGIHYWEASVDRYDGNADIVIGVAQPPVNRRAMLGKDVHGWSMYVDGQRSWFFHADTHHGRMSGGVVGCGSVIGVAIDCDRGTLSFAINDTPLCVHAFKNMPRGLYCPAFSVNCKSTITRKITTKKIMSYTTNFPHSRKRTVYVGGFGEEVNEKILTLAFIPFGDIVGVSIPLDNETGKHRGFGFVEFELPEDSAAAIDNMNDSEIYGKTVRVNFARPPKVNERSQRPIWADDEWLKQYGQGSGQNEAENGGGKPVEEAAAGSAAEMEENGGEKSQKLQRVYLGIKIGIRYIGRIVIELRSDVVPKTAENFRALCTGERGFGFEGSKFHRIIPKFMLQAGDFTAGDGTGGHSIYGEKFEDENFKLKHLMPGTVSMANCGANTNGSQFFICTEKAEWLDGKHVVFGHVVEGMNIVRQVEQQGTPAGKPTMQVSISECGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTU7</accession>
    <name>A0A914GTU7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
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            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11194.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11194.t1"/>
        <property type="gene ID" value="Gr19_v10_g11194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11194.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8343" checksum="115B15B37D741072" modified="2023-02-22" version="1">MPSTNQSLPEVPEKKEAADVSCLRRSVRKKVVGKGSDDALSESLVSQLSKEWLIKKLSMKCVLTKCEVYIKMGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTX5</accession>
    <name>A0A914GTX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11180.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11180.t2"/>
        <property type="gene ID" value="Gr19_v10_g11180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11180.t2"/>
        </source>
    </evidence>
    <sequence length="377" mass="41166" checksum="00C4E6DA93B36F53" modified="2023-02-22" version="1">MQNCIVCGKATTREKGFPFPTDARFIRYCLHLKLNPKKANKKEGGKIVNVSRMALPRPSRLTLDQLLEKNVGMSTSAAVSSQQNVSVSSNRQSASTSTALSSHTPAGSEVFGSLHNRQNRSVIQSPTDWQGLPRHCQQVQLGHAHASSNASNLTITDDLADAAKKTLVLFRKRNEEYSANDSFVDQKSVIDWLRQSFNLPANAICHVSLPAIAGNCQVVFLLFVNLRTAENILKMCTEQNLQQCILNWAADVLKDGAQFLKQKVDSVGSFSSSSRRHLDVNESFRVLLQPIPGTFGGSVFSDENAWRNLAAAMVPAYNNLIAAASSQLQHQTLHSDLAAAAVRNTPNAETNPTDPSSLQTITSEIDKIIRQGPTDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU87</accession>
    <name>A0A914GU87_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GU87"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11386.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11386.t2"/>
        <property type="gene ID" value="Gr19_v10_g11386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11386.t2"/>
        </source>
    </evidence>
    <sequence length="193" mass="21403" checksum="41A028BE978B541A" modified="2023-02-22" version="1">MQFVPIRGRYGYYQTVNKGVAIKYGLTQQQRRPMLPNNWVEVAEREADEQRQFVDDGLGRFGRRQKDQRPESEPTPDYDNETGGRWCVAGGGGRGGVDRTVAVPDGRAPPAPPLSFLLRQSLLGNSRTQSPSSLRQKSEIGAGEKQQNPFDLMANTANAFMSSTFRDEHPKKIMLFGDGGGSTKTKTVVDVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUD9</accession>
    <name>A0A914GUD9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUD9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10878.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10878.t1"/>
        <property type="gene ID" value="Gr19_v10_g10878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10878.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9219" checksum="2D12A1A9239255BE" modified="2023-02-22" version="1">MLLKLYVIIFGQNYPSRFVSVQQCGQYCPVREQPGGQIGDRNASFYRFPICAFWPGNAEETTNCGSNDIIARNIGIRSIGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUZ8</accession>
    <name>A0A914GUZ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11432.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11432.t1"/>
        <property type="gene ID" value="Gr19_v10_g11432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11432.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18649" checksum="843087D2B2EF9EFC" modified="2023-02-22" version="1">MGMGTGVGAVRGPCRRGFRLQAVDLLLPSENGLQTVLELVGRPIRFFLLRFKNFIQHEAGKPLLHFHLEGGGVVRLILLAHLHTYAFDLVDEGAEVGTKGIAASDEGQFPKGVVEGPSEWRRGAEYFGGGGFQRRALRAHGARIIPKTVHLDSARTLRRARFSAARLGAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV79</accession>
    <name>A0A914GV79_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Glucosylceramidase</fullName>
            <ecNumber evidence="5 12">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:81447"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83264"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:34755"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:70815"/>
            <dbReference type="ChEBI" id="CHEBI:70846"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:34756"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="5 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914GV79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11648.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11648.t1"/>
        <property type="gene ID" value="Gr19_v10_g11648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111166" description="Glucosylceramidase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="14">
        <location>
            <begin position="91"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="14">
        <location>
            <begin position="572"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="14">
        <location>
            <begin position="690"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="15">
        <location>
            <begin position="890"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11648.t1"/>
        </source>
    </evidence>
    <sequence length="955" mass="107105" checksum="FF5D72E351BD2398" modified="2023-02-22" version="1">MLKLAFKLLLSILIIHQCLAEWKPCKKRNAEHCDSPEAIGDLNDSHKLVYYVSDPAEKRLARFELAPNDAASAKGIVEVRVDASQKRQTIFGFGGAFTDAVGINLNALNEQTRDALLGAYYDSEYGIGYTIGRVPIASCDFSTHAYSYLDTPNDFDLTTFALAKEDFELKIPYLHAAKKLVGEGLRLFASPWSAPAWMKNTGRMIGWGFLKGSVDDKYYRCYAHYLQRFFEEYSRHGVTFWGMTTENEPGAGGLSFWRWQAMYLSATTQREFAVKLLSPALKKSILFESAQKIYGTPEGVEAIDGIAVHWYAPSNYDKLEKTHNLRPDKFILASEACTGHRRSEHKPLLGDWSRGKEYAHDILNDLRNWVVGWTDWNLCLDLEGGPNLVRNFVDAPIIVNASAGEFYKQPMFYALAHFSRFVPRDSVVISSTLFTADGTKLPDKTLEEENGLRVLVLINPDQSLRNISVFDEVEGRRWTVPLAGDSIVTAVWKPKNAFDQDSFVCVCSAEHCDSPEAIGDLNDSHKLVYYVSDPADKRLARFELAPTANNAGTAKGIVEVRVDAAQKRQRIFGFGGAFTDAAGISLNALNEQTRDALLGAYYDPKIGIGYTIGPRANRQLRLLHPRLFVLGHAQRLRPHHFCIPYLHAVTKLVGEGLRLFATPWSAPGWMKNTSKMIGWGHLKGSGNMPSWAFQAMYLSATTQREFAVKLLSPILKQSPASKNLKIMAHDDQRHDVFEAAQKFYETPEGVEVIDGIAVHWYIPSTFDQLAKTHNLRPDKFILSTEACNGVSDNKPSLGDWTRGRAYAHDILNDLRNWVVGWTDWNLCLDLQGGPNLVRNFVDSPIIVNASAGEFYKQPMFYALAHFSRFVPRDSVVISSTLFSADLADKTLEKENVEHIAFQTPNGLRVLVLINPDQSLRNISVFDEVEGRRWTVPLAGDSIVTAVWKPKKALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVA4</accession>
    <name>A0A914GVA4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Paired box protein Pax-6</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GVA4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1151.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1151.t1"/>
        <property type="gene ID" value="Gr19_v10_g1151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF49">
        <property type="entry name" value="PAIRED BOX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="13">
        <location>
            <begin position="50"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="284"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="286"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1151.t1"/>
        </source>
    </evidence>
    <sequence length="453" mass="49124" checksum="D5A779C814CC7C4A" modified="2023-02-22" version="1">MDTEMQMTAASNSATVRQQQSEGIQRQMPMDDGTALPQNGARITFENFLGQGRVNQLGGVFINGRPLPHEKRVQIVEMARRGIKPCKISRELKVSHGAVSKILNRFHETGSISPGQIGGNPRSRLSIQAVRQHILRLREEQPSLSAGQVQQMLVQRSICSRQNVPSSSRINRLLKAYKQQQQQMVKPRPKSAEAAKSGGEKPLSHSIENILGGDNGGKQSPNGHANGTIGGAEVGRPLAVVSPPSSSASSVSSSNAAQIAPGSDEENQQQQQQQQHSQNDTFLADGRRARTSFSAKQLRILEQTFKNSPYPTPQQKECLIKVTELDEDKIITWFSNRRARNRRKAFQQQQHPPPQQMLSFSSANSTATSPQSSIAVNTTPMAINQNSICPPALFPFPAAAFFPTLFAPTGAFTPFGLLAANGGTSTAAAMNLNCAVSAVQKQQKMCVDGTAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVN7</accession>
    <name>A0A914GVN7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GVN7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11616.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11616.t1"/>
        <property type="gene ID" value="Gr19_v10_g11616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="62"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="164"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="276"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="486"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="15">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11616.t1"/>
        </source>
    </evidence>
    <sequence length="641" mass="70578" checksum="26AEACF941C2E638" modified="2023-02-22" version="1">MMMIGERYCFWIRTTDERTFWVSERASDGGIRNCVTAPCTEFGVFFVSKIMASFNAFAWESFFFGKLERSEAERLMANCESGTFLIRESSTAQSCFSLCVKGEDGHFLNYLIEKLEVQASGGLTQYRISTQTFADMPSLLNHFKVHNVSAGPTPIKLLKPLEKPFLDKVMAKYKFEPERISDLPFESGELLEILGKPEHGWWLARNCLRETGMIPANRVKPCDDCDDELSVLNPSTNSSSITNEGADGLAGNRSSAHSVGEQQQHQTAGQQQQKLQENSWVVVKVGRQPSIYDSDSLSIKQGQLLYLQEILSNGMCRGANENGKVGLFPITFVEPTASNIVATDDPTQNASRTLEHALSWHNSNSFFCSIFVPIEFGGGGCFGTMMDDFEYITANVAGPGTDAAVLEEDFEGCDCAEGKCTSSTNADDDKCRCLPGKMDNYNPITGKWMHGIDSAEAAHLECHQNCKCAWTPEQCANRQIQYGVRQPIRIAPCANGKGVGVFASALIETGRFVVEYVGEVIGEEEARRRIGTADAQQHNYLFTIREFIQGECRSTFIDARHKGNISRFINHSCEPNLALQVVRLGRQCPSLAMFASRDIQPGEELSYSYGFLAGADAALSGKACLCGASTCMGRLPSASTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVT2</accession>
    <name>A0A914GVT2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVT2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1165.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1165.t1"/>
        <property type="gene ID" value="Gr19_v10_g1165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1165.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10849" checksum="0749D190C35E63A2" modified="2023-02-22" version="1">MADTIYYTYIYDAVPNRKNKDAIRRNFQWDIASTTTLAAIVAVIIASIVVICALTVAVVVLWRTIRDFRKQLKAFREQREADMNDPALNTMPAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY42</accession>
    <name>A0A914GY42_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GY42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11448.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11448.t2"/>
        <property type="gene ID" value="Gr19_v10_g11448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11448.t2"/>
        </source>
    </evidence>
    <sequence length="237" mass="26073" checksum="ED5A31A6BAD94B47" modified="2023-02-22" version="1">MVAPRRPGRRNGSAEIPKRCRRPSCSRSCMQLASYISKMPKVPKMVPPGLKNRAPSPFIAWCRDYLMHIKRKTDLTPPAGIPGPDGECVYMPPNRFPNTQSSRSIEPAMAQGGVHHKLADNYYLDRDARRDVKPPMPVYKADGSVALLQGAVVGAPTTLSILSADKMDKDISAAFNKGPAQNFGLNFPTPGFGYEWEAQRRGRGVLAEEEPGTRQTREVRHVSEAAAMTRELISNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYI5</accession>
    <name>A0A914GYI5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYI5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12364.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12364.t1"/>
        <property type="gene ID" value="Gr19_v10_g12364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04013">
        <property type="entry name" value="C2_SynGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05136">
        <property type="entry name" value="RasGAP_DAB2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057606">
        <property type="entry name" value="SynGAP1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25321">
        <property type="entry name" value="PH_RASGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="450"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="651"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12364.t1"/>
        </source>
    </evidence>
    <sequence length="1231" mass="136785" checksum="6B613DB387AE900D" modified="2023-02-22" version="1">MFLQLPLDFAHDDSVIVDFEFVRFPHRHSKFLSVRGFSSGIYSKHKLFLGAPSLEMELIVALLERQEILEMRGAGDGRPTAKLPKGVISDFAPGLSSPKYFAPKSTESTDFFKSSIGAECATMSAPPWHPLSLLGAILSVLRWLCQWTVRRVCCCSSRDDKMSSVGHGEEGRRGQCRRSPLPLHGLGELTDPLLANLDQPLQLHTPPDDEENVSATELDGSAGDRGIGRGETRSLDRHFVTWQGRRHNETTQLARDISSPGVALLDPSSLHNSTVSASQRFANFLSRRLKRTKSFPKLTRTRDNNNNNQRGSDHQLVAVSVPAEGVAMRDILGESALRTDEEWGGRVKSMISQAPLSLHMNGVNARGNAFVHRHSALSLRPSRSHESLLLLNAGQQQPLAKSPSESHQQDLLLRRLQPVHASISPDNCCFLLDNNVYSCRTSDERSRWMDSVRRRMNPKIDRVHRVENCLAIWVLEAKGVPAKRRFFCELSLDGQLKARTSTKGMSDGICFWGESFEFGSLPPARRLCIDLFREADTKKTASTRRARGGAEREDRHTLIGLVNIPLTELAGRQPVEKWYSVSSNDPNANSNNSNNPANANGADSLPSIRVKARYQSVHILPLRAYKPLREYLRLHFLPFCATFEPILGVKAKEDFACALVRVLQHERRAAEALADLAMVEVDGQENDHLLFRGNSLATKAVEAYMKLVASDFLQSVLGDFVHHLLAANLNCEVDPLRLLSPSASSLERNRHQLTKKVEEAWSRIRHSADHFPHPLRSLFSTVRRQLELSGRAELADNLLSSCIFLRFLCPAILSPSLFGLASEYPTGIAARNLTLVAKSLQTLANFTRFGGKESYMEFMNGFVEREWRNMQCFLRKISAPSPASEFDEDCLRAIRSNVDLGKELSLLHCYLSEAWTPKLGANNTISSGTSSIALREVLMAVNRKGGEDEAEEDEQHSAHNNPPSDYENNSMSMMCCNGRGSCGSPTEMKCHVKSCVVLPPKQPFVNVKQYPHQQMNNILPQNNLVPAPFSSPNSVTSNHLDSADDYVLSSALAQLQGHSQQKCQPTTTVHVYDETPRGGGVIEHHLYDEVAMDGTEPPADDHHRLKHQQQNRMIKMKMSVTSSVVNPSQRAVAASCTPRVIQKCHQLRKPSIGERNEVAEDEDEAAGSDSTEEEEMAFSNSSVEIFHQRRAMAQRKKSLGASSADSSTAPTLLAELMAAVWADGAQLGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZM1</accession>
    <name>A0A914GZM1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZM1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12578.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12578.t1"/>
        <property type="gene ID" value="Gr19_v10_g12578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="58"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12578.t1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45986" checksum="D857DDD3A73F5D5A" modified="2023-02-22" version="1">MLDRFIRNFLNGQQIIHKIRHVQTVRLTFLHKCIKNECPAVLSWDTRMASTSSKRPSQSSKLLNDYRNNRIANLQLADLGNDILEFARDPRGSRFIQQKLERANPTETAHLMDALRGHVLTLALHKFGSHVIETTLKSVDKASQMKIINEISAQVLILSLHKCGSWVTRCVLDNCTEHQKRPMLEQLLGNVLSLATDTYGSHVIRHVIEHGLPEDRERIVRSLHENITSMSVHKYGSLVIRCVLDNCTEHQKRPVLEQLLGNVLSLATDQYGCFVIEHVIEHGLPEDRERIVRSLQGNIIMYNGHLNSFCSVIHKCFIFGTMEQRNALIDEFCADNGSGSPPLLEMMKHPFGNKVVQKMMDVADSARRQKILLAIKTAPLKNTAKRSSESLTTVKVQQQRGGTEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H018</accession>
    <name>A0A914H018_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H018"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12796.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12796.t1"/>
        <property type="gene ID" value="Gr19_v10_g12796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12796.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33236" checksum="3F6FA76495604B64" modified="2023-02-22" version="1">MEEKGVQQYQHCMRSEVINLNLNKILNLLNRLQPFFLIHPPDTCPSVRSSTDFDCPKTANTDVNARDTSQCLQFLTSSERRERQSNCSKLLTGHSQQIVVRVGHCAVAVRSDFAHGHSGVHFARTAVKTGEGKRRRRQTKHYNRRKTFLKLPCTSVRPRPNVKPNGDDQYVVERILAVFARGDRRAYFLDWHGSPRKESWVVSEDCDCVEYVAQFTAVTTAEGVLDCLLGESVPEHILELLQGSTKFIHVREMLGTNVAPATDVNLSFAPNINERQKAKALRTLGSFIKECIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H060</accession>
    <name>A0A914H060_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Apyrase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the apyrase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H060"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12965.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12965.t2"/>
        <property type="gene ID" value="Gr19_v10_g12965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.100:FF:000001">
        <property type="entry name" value="Soluble calcium-activated nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
        <property type="entry name" value="Apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036258">
        <property type="entry name" value="Apyrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06079">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101887">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR609283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12965.t2"/>
        </source>
    </evidence>
    <sequence length="422" mass="48015" checksum="888CC66A9A12DCBB" modified="2023-02-22" version="1">MRICETTSNFFHAAMSSSLRRQMRPPISFFVFDAAKRPKAKSADMTHPRHSNVLVGSTLAIWSLIFLLLAAFVSLQYYLPKAASSCLCPDGEFVGLTAEGRYNDSSFGKPQTLPDGRVQYELAVVSDLDQDSKVKGQDEWHSFLCRGRLFFHPDGHSVKVEWFDTAAAKHNLSSELSSGGRAMELSDLCVYDGHLLTVDDRTGVVYRMDDFKKMVPWVLLNDGPGNTIKGFKGEWMTVRDKMLYVGGLGKEWTTQAGDYKNNHPMYVKVITPNGEVSHVDWTDHYKALRRRVDIEWPGYMIHESGQWSDVHKKWFFLPRRASKLKYNDVDDEHMGKNWLLTADADFANIDFREIGVIRDGFRGFSAFQFLPNTADDVIVALKSEERNSKPVASYLFIYRLSTNEVLLDDERVGPYKFEGLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0B1</accession>
    <name>A0A914H0B1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0B1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12443.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12443.t1"/>
        <property type="gene ID" value="Gr19_v10_g12443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF32">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="535"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12443.t1"/>
        </source>
    </evidence>
    <sequence length="634" mass="69230" checksum="B95A4B0F5E1384D5" modified="2023-02-22" version="1">MATSHAGHHSHHHKGAGGSGGHHLQQCQQQQHATPAATPHAVPSPILCPAMAPQAIASPPLPPRPSPHWLTPSSAEEVTEDLNMAAVNTTTGSSSCLGGRSSRGPPLTQLHQFSLPSPQEMAPVARQIPPEMERETNRWRQYAAAVLLHGRKGMPPKGLDEDDEEFRGRRMTVTYRFPTNGAAGGNSDQTAAAPHHYQQIYRRPQRALRKLSMGHQRHSADERAEISAAAEEAFAAMVLNNGGSGVIGEEERRLYLQERSLLSANYAILRKSVDRFEVVGAFHRFHTEAYRHFLQSLTCYDLSPAHGLIVMLDAELTIQKAVQILVAHPAPRVAIISNVRDGLWAMFTVTDCLRALQRAHQSGNIDLGGRTLRYFVEQLHGGRRLISVDDQSSVWDLARVFSLNRVHRVPVFSAENGELMAVLCPRAICVELLKLISSKCSLSPDLSTLALSSCQVGTWGEIASIGADESCARAVDLFLDRQVSALPVLSSAGGALLGVVDKNNLLDKLFDQLGAQPTPERCMELMAETPVKDLLPPLARRRTVQNDISVTEALTVLAKDGLSESLFVLDTEGRLCGVISHTDILEFILRYEQGNGNGNGNGDRPSVPSGHWRFWANQIQSDGPMFFESSAQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0M9</accession>
    <name>A0A914H0M9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="12">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914H0M9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12140.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12140.t1"/>
        <property type="gene ID" value="Gr19_v10_g12140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000036">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="77"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="275"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12140.t1"/>
        </source>
    </evidence>
    <sequence length="653" mass="74302" checksum="0DDFFC4A7442D790" modified="2023-02-22" version="1">MDLFVSSLEYIGGLFDVVDLVVLGAIAVFAVGYYVRTQTLSASSKIRFPESTPIRNGTLEKVDRSFLGRMKSEDRQILILFGSQTGTAEELAGRMAKDLSRFGKKPLLMDPEEIEAEDLPKIVELTDPVLLLFVATYGEGDPTDNAQALHEFFTSADCDLAGLKYVVFGLGNKTYEHFNAVGKFFDKRLEELGAERVFEMGIADDDANLEEDFMRWRELFLPTLAQRFSWDLVGNGALDRQYRLEIIGEPTKHLFTGEFGRIGAYERQRPPFEPKNPFLATIAVNRELHLPSSDRSCRHVEFSVDKALIRYEAGDHIAIFPTNDLGLVDVLASLLEVDLDTVFKLVNTDVESTKKHPFPCPCTFRTALTHYVDICSPVKSHVLKALVEFSADEATKDKLSLLSTASEDGLHEYAQFIVKERRNIVDVLQHFPSCKPPLDLLLELLPRLQARYYSISSSPRIDASRVAVTAVVLRYPMGDRLVKGVCTNFLSDRAEGASAPVFIRKSTLRLPHRLQTPVVMIGPGTGLAPFRGFLHERMWHKKQGKEVGEMHLFFGCRHPEHDHIYKDEMEEFVQIGLLTQHHVAYSRFQSEKVYVQHKLWENRQRMWELVQEGAAVYVCGDARNMARDVQNMFYKIFAEDMEKQRRYQADVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1H5</accession>
    <name>A0A914H1H5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1H5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13052.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13052.t1"/>
        <property type="gene ID" value="Gr19_v10_g13052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13052.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12224" checksum="ECB249C4A6829949" modified="2023-02-22" version="1">MKAELKRAGFKNSYQNEIDETVAKELGITDRTISNWKRELGQTEPKKYSRSQQNKLMKHYYEIKGKNSKMRDEDIAKILKIGRRTLSDNSPTTPVVALGKFFGNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H378</accession>
    <name>A0A914H378_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H378"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12843.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12843.t2"/>
        <property type="gene ID" value="Gr19_v10_g12843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12843.t2"/>
        </source>
    </evidence>
    <sequence length="308" mass="34624" checksum="98B911AE229FF6ED" modified="2023-02-22" version="1">MSCRLHFGKKFYFTKTAKAAPIDLSSKKFTSCCCNASSVSAHFLPPTVVNMPNRMRQMVHLEWDGSTTVRYGRATPQALNLYFALPAAAQFPTEFTAPSSLTFTVMIDSLDACTCITQSVYDNILAFAWNRRHPNRIMPDEVVYLTWNQWHSSKVSTDGDGRAIFFSATNFSGFENADNPSSWTILSGWQRRARITVPAENGTLMLEYGSRLALLYNVPAAKIERRLSFRLLSQQELLQLHPWLGSQLFAGQTPRCDWALNFSHKYRLLFPTNGIMAADGRRRRNDNTKNGGAPESDGDSDDIDHCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H387</accession>
    <name>A0A914H387_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H387"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1344.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1344.t1"/>
        <property type="gene ID" value="Gr19_v10_g1344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="223"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1344.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45240" checksum="C8712D4EAC917790" modified="2023-02-22" version="1">MPKPADSDGPPQILHKSVSQRPIESTTPATTLGGRQSLNTVLNGLNWLVDEICTSIMGKDGQTQSENANIYAGNNLEIADFYGQNVAASSKTKKTEKLNKEQNIQKEQKTEKLKKSRSNRSQPQSPSMSPISTSLERMKKDKSIEKQRQNDPPRISNILNNNSNGGRPADLRYKFNPLSAEEQKDYLNILLAGKPNKYQLENIFERKEEFKLFDPDKTIANPSKVKENQGNGDCLFRSIAYALLGTEELHKEVRQHIANYYAKYIGRENALPENERWIREMLLIDQSGDYPNFQCIKQYVEYLKISGITRWGGLVDIVAAAKAFNVNVMLFYPHIIKNDWICYSPDTVDQTTAWNQKKGRPTLFLQFVKNNHYNVILGLAPKPSNGTGGIKQKSITYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3A3</accession>
    <name>A0A914H3A3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger E-box-binding homeobox protein zag-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3A3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13448.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13448.t2"/>
        <property type="gene ID" value="Gr19_v10_g13448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022603">
        <property type="term" value="P:regulation of anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000026">
        <property type="term" value="P:regulation of multicellular organismal development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000013">
        <property type="entry name" value="Putative zinc finger E-box-binding homeobox 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF27">
        <property type="entry name" value="ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="371"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="778"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="373"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="445"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="597"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="618"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="812"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13448.t2"/>
        </source>
    </evidence>
    <sequence length="835" mass="93912" checksum="D97C4D1CD6F7B55B" modified="2023-02-22" version="1">MDLCRRRPSILKTINSPLLIADRFFPIVFAQMTDLSANLLIQQHQQHQQTEHHLHQLQNERKFKCAECAKAFKFKHHLKEHLRIHSGEKPFECRHCLKRFSHSGSYSSHMSSKKCHQQQQQLFASRQQRQLQGDPSPVPATLPLSSGLFVPHPPLVHPAMPSSPPSALFPSAISSSSSMSSPSSPFLDQLRLYFQQLQSVLYASASLQHQMAAAATFTPTNFFAQAATFAAATALATGQSPQKSEEEEEKNGCYNKSRTSIFSDVGENVQQNWKQQQQNCANVPSFAAAIDPNRMNTAGNVFRTFLLQQKKEKAEEGAEEGRLLMKTEAEGVEEDEATHNETGAPLAEEFDSAEENGADILAEWRPSATGGSALRPRSFLSDAQVKILAEQFRHNLLPSKYQLSEMAERIGVNKRVVQVWFQNMRAKAKRANRLSAISERLSRNAAMRNAKKDGTGNNRKLDFDTNGDQTQPNEGKETKPNTLPPLDPDFFRRLVNNVISREGGGVKEAKMEENPLDLSLRRNAEEEEGGKEMKMNEDEQQLVEETTQKHNNKKEEEEEEEEKPEREREECRYWPTPSQFFGIGFMDKGCSQSLHEMFQRSTSGQSSPALGSAGELPSSSSSSLSDHLHLQQQHSPHVSTRSSSSTIWPSSSEISPTLLSMLGAHPSSTELPHLNEQEVINVTAGNGKSSPNGVTERPRKCQAPAQKRRRTQQTDESGGGLYICDLCDKSFNKQSSLARHKYEHSGQRPYKCPICEKAFKHKHHLTEHNRLHSGEKPFQCNKCLKRFSHSGSYSQHMNHRYAYCKPFMQQRQRDAEEENKKAIAGKEEAPAGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3V4</accession>
    <name>A0A914H3V4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3V4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13906.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13906.t1"/>
        <property type="gene ID" value="Gr19_v10_g13906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037702355" evidence="2">
        <location>
            <begin position="21"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13906.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45832" checksum="F8877B8FBBB19BCC" modified="2023-02-22" version="1">MAPQSLVLVPLFCLVMLARHSEPWGLLNHECTQSLRHVKSHNPWAEVNLLENDWKWKDFSESNANTWSDSIECYSDVSCETYRCKDEKGNDIFVINACAKEKIKDEKSTKCTNDELEPYCTSSSSKGKPVCSQCYGADCNKDRINLEVENVEPTEKDPEVVATTSTTTTTTTKAKTTQKVNPTKPNKTTTGGHRENCSQSFRYAKDFKLPPALKQLMMQKMRDLSKNYTVDCQVKAVCQTYHCKDENKNDKFTYNSCIEPGFGRHCYNAVLDKFCPAPWKFSCEICDGEKCNKEKIPLEMGNKAPPLTNTTPDNNVDSGNDSKMLCLINKICNVEKNWNAKLSRRFAVRSLKKSKKCKELVNKVMAKDDKNLGDDLADELSESIKKVGLVFVDDYIFAFEKLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4I3</accession>
    <name>A0A914H4I3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Toll-interacting protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tollip family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H4I3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13577.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13577.t1"/>
        <property type="gene ID" value="Gr19_v10_g13577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14363">
        <property type="entry name" value="CUE_TOLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000214">
        <property type="entry name" value="Toll-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000036">
        <property type="entry name" value="Toll-interacting protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041799">
        <property type="entry name" value="TOLIP_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="90"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="8">
        <location>
            <begin position="266"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13577.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="33697" checksum="A64C9E6693AB986E" modified="2023-02-22" version="1">MSTASNSTTISAAEPLPTKTSLKLAELRSRVLIGELAPDFLRIPITPANPSTATGANGQSVTAQPPQQQIQMVVPGAPQPFAYVNPANLEPEFERQTHFYSFVPPHTRGRIAVKIVEAKLTKNYGLPGVRMDPYVRVRIGNTLFETPTCVNGGKSPHWNRTVNAYLPDGVESIYLQIYDERAFTSDECVAWAHVMLPHGIFSQETIDEWYQLSGPQGEGKEGVVNLVISFTPVPQQQQQQQPASAATRPGGDDQTIGAASAAQMPFSEADLDELQEMFPSIDKEVIRTVLEANRGAKDPTVNALIEMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H503</accession>
    <name>A0A914H503_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H503"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1422.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1422.t1"/>
        <property type="gene ID" value="Gr19_v10_g1422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1422.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="33134" checksum="071B99A2D6466621" modified="2023-02-22" version="1">MELTQRINKLEKDLRYQKHLEVQKKCQMRIEIAVIKFKIKIEEKMEHYNAIVELINDLSAKGKPPNYYEENEQLLKDTETVIQEIRRLDSQIMVYRRASSALNAACELHMDSNQLELYESQYSNAFIHFIAEGAEYCSALKMGKSVDYPEQRQYNFFEELIEEIADTENAAKVVKKMQFSLNKTEQKKDYDAVLGPRGVLRHSGVLMREGKIGIEGRIEIGGEQKTIKKSLLKTRKLREQFYKVSNQKTKAAFEVRLMFSEPRKQKPLSEHKLLALHINAMAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H691</accession>
    <name>A0A914H691_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H691"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14071.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14071.t1"/>
        <property type="gene ID" value="Gr19_v10_g14071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036673072" evidence="2">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14071.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35879" checksum="FB531C776E33A179" modified="2023-02-22" version="1">MEKIWILILVSFFATNSLDKAESVQLEELPLQTFDELFVEEWWDNEEAEDLQRPPTIFGQIEHNSTDQNPPRTESDHFGQIEHNSTDQNPPLTESDHFGQIEPNSTDQNLPLTESDHFDNAKNGEEQNEIKKVISSNEKIAEDERKQKFDQRKAELTRDGFKGSYKELDKTVAKELGLSFTTICNWKRELGQTKPTHKYSRSEQTELMKTNGALPPCPPRATTNLVIFPTWACTFIRHLLFSLLRVLLDKRTAVKVAEAGRASTHGGGAPAAGFGRAAALDFCKPKLRTRYTRPVGTAWAARKTREAGVPGAAGAGPAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6J4</accession>
    <name>A0A914H6J4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914H6J4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14278.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14278.t2"/>
        <property type="gene ID" value="Gr19_v10_g14278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    <sequence length="512" mass="57999" checksum="C8D5DA9764AEA263" modified="2023-02-22" version="1">MKATKFVTFAALLLFIKLGNENTTSTHVETSKTKSDSNIQEDGGLSAQDLEGLIEQAKIMAMNIGLITRTNAHKDKNDVAEFVPFTLFPSPFPRKLFLQAYNIQKEMNLLYFLISLDHKFLEETLQTVAETNENVRGMLGIFKKVNEEGNKQPITLVLERSDYMAHVNKNENEQNFELKQIEVNIGPMGGPARADRIAKIHRHLMQKTRHDLTNMPENDASTIIAMGLYMAWKSFGDPEAIMVVVAGRMYQNFEQHQLSQKIQEMSDYQIKIAHLSLAECGKELTLDENDFILRYNGKAVALVYHKTFVIKPTQEQLNARLKIERSTAIKCPTVALELACTKKVQQALALPGVLERFITNKEVVASIRSTFAGLWGLEKDDEETRQIIEDAIENPDNYVLKPSEEGGGNNFWGEEISQKLRTFDPSERAAHILMQRLYPMPMKNFLVRPFKPVKLEEVVSELSIYGFLLGNAREKSVQSNERRGFMLRTKLENTTEGGIGAGGGFHDSIYLF</sequence>
</entry>
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    </evidence>
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            <dbReference type="WBParaSite" id="Gr19_v10_g14298.t1"/>
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    </evidence>
    <sequence length="513" mass="56294" checksum="8BC8A3732F0BB800" modified="2023-02-22" version="1">MPTFLFLAAICLLVAASILLETDASPNKNTKLEKEGSSSGNAESTDTDARKANSLAGRMKHLLDTGHRADVHFLVGKGDKKKLVKAHKAILEIASDVFVAMFRFDEANAKAAAAAAGTDPSEEIKPVKVPDEEVGAFKAMLAFIYADDLSELNGDNAISVLYAADKYNLPELVNSCLNFPIPELRNVFVAFDRARFLGKENAEALILSEAFLQMDQQLLCEILARDELCISEEITIWNAALRWADKKCRQKGKECSAKNRRAMLGPAIFKIRFPLIPQKDFTEKIVPSGVLEEAEQAGVYQYHSHLDRALPKPYQLHFPTNGRALPGLTLQNRWDSAARHEKLALSEPARLIVQIIGKNGEWRSVLAERPIPKGKFGIFYYEVTISGKGNGIHIGLATKQMPLDKWVGENKGTYAYANNGTFWAEGVGAEATNYDSDNDVEGFGVGDVIGCGVDLANRQIIYTLNGERLNTAGLHVDSAADLFPCISVYVLGTKIEANFGPNFKFTLPKASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6V9</accession>
    <name>A0A914H6V9_GLORO</name>
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        <submittedName>
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        </submittedName>
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        <name type="common">Golden nematode worm</name>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="Gr19_v10_g13772"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="61"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13772.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13772.t2"/>
        </source>
    </evidence>
    <sequence length="202" mass="23448" checksum="02FB89AD9D850821" modified="2023-02-22" version="1">MEEIGNSSENAKVCISCHNPSSGAHFCKKCFEPCQQFRRALSQSMERKDTAQKSFVRRERVHGGGRKLTDADFDNALADWVKELRGRKLRVFRNMILTAAKKICSQYPKMDEFSGSKGWLDCFMKRHNFTLRRPTSVAQKRMERFQTLVGRNRKENPTKSMQAERHNFLHIHLRHKLFTYTCSARGQESNGKSYQINASRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6X9</accession>
    <name>A0A914H6X9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6X9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14571.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14571.t2"/>
        <property type="gene ID" value="Gr19_v10_g14571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF22">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14571.t2"/>
        </source>
    </evidence>
    <sequence length="253" mass="28607" checksum="4649FE96B9A3F027" modified="2023-02-22" version="1">MLVWRTYSFSSNQLAHRPTWTQKMTFLQVVIISFFNAVCSGIYILMQFIRISEIYIIIGTYTWLFAHGCPPIVYLLLNVRIRKDFANFVRAILRRPSRGHAVAYALNTTAWVNSGTSANEVVQQGLPCGELTSDELVSIFLLYEQPDCVLPESEAVYIRGLPWNILAKNAGFTTQKQSELELCRFGNTAHCFTNGGKRGLHTNDQTTFSRGFTHFMPFSKSKLMDPNNGWYDAKNDTAILEAEVTADKPDGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7K1</accession>
    <name>A0A914H7K1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H7K1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13949.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13949.t2"/>
        <property type="gene ID" value="Gr19_v10_g13949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WH2" evidence="8">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13949.t2"/>
        </source>
    </evidence>
    <sequence length="875" mass="98602" checksum="11FC2BA1717010EB" modified="2023-02-22" version="1">MANQTQFQQLVPFVLKENAVGDTLSFSRKFVSSSLTCFSSTGRTSISLSRHAEQIFSEIHRETLKIDHRANTLFLRVERLAQKLSQSQGTNNLKGVMDQVTLEEAAMRKAFKSFNIIDQHSLDRQTLPQSLLEQYQNCDAPPQLNQLNPYREDEKEALCYYTDPSYFFELWRNEVLKECDGGLIEKKRAGRSSTSPSRQRRRQQQDIPQHQQNPSFAHHVSSRSSDYSRFAPQFGHQNKSQQNRARHGFDPGHFSTSIAADVLHFPAEYQTPQSLLLSGLLHQPPPPGMSMVTANTENCVTEIIAKFVSRIKMRKCRGEFLGRWFGCCVPGRGRRRASSASSSQHSLLHNDHDEPSTHCLLLLSGSKVEFKPSNGSTETSELKTQQSPNQQPDDSAVEQQPQQQIQSMQQIPPSVCISSVPPPPPPPPPVNFSAKIRKPSSTGAQDNRSLLLIQIQEGVKLKRVRQQEELAEKRAVATSNDVAAILRKRMEHCLGDSDSSSNLSRNVPKFDWISINANFMNSAATMTQKLMSAAINPQRLLRSLLPSLREELAASLTNDLRGAEAKISREYIQQLFDYTMGEGKFARSGLALRTYLALDPSPSDVQFHNAVKVSLAIEMLQTFFLIEDDIMDGATRRRGKPCRHQLPGVGLKAINDGLLLDCGIDNVVRRTLPSHPKMYAILHDFSEAKQKTVIGQLLDTNTELDEFSWSRYSAIVESKTSHYSYFLPLIVGYHLADCTPTSPTKLRQIAYRIGDLFQAQDDFLDCFGDPEITGKSNLTDLAEGKCTWVTCALVDKLSKEAPEKLNLFRENFGKKSVQQLKLARQILLQEGIGQKFEHYQTELVEDIRSELAQLPAEPIRNILHQTLDDIVNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7R2</accession>
    <name>A0A914H7R2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP14/UBP6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914H7R2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14504.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14504.t1"/>
        <property type="gene ID" value="Gr19_v10_g14504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="122"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="420"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14504.t1"/>
        </source>
    </evidence>
    <sequence length="527" mass="59426" checksum="5999B46BCC506DDE" modified="2023-02-22" version="1">MCSITKEGAQIKLSNTSASAKMPRVKIKWGTEELSVNANLEETPLLFKAQLFELTNIPPERQKLIVRGKTISDESWNGIKIQDGSVIMLIGSAGSMLVKSENVESSSLASSAEKARHKPLPVGLRNLGNTCYMNSSLQCLKIIPEFEAALKQFNAGQSAERADGSQRIKLFTNSLEELYNEMNNLAKEQTNSYPEIVPMLLVHVFRQTFPQFDTQDGRGQHQQQDANECFCEMLRMISDETVSMLEKNDDKSGVPSARAQKVPLKQFFEIEHEVVVKCLEEGSNDEPQRHKEKVLQLSCFLDQEVRYIQAGIRNKMVEEIEKKSKSLDRNAKFEKRSMVSRLPAYLSVQMVRFFYKEEKNISAKILKDVKFPIVLDVFDFCNSELQDKLKPARAALKEYDDAKIELMRKAKLSEGAEAKPDLTPSGFHPNSFSDDIGSNNSGFYELKCLITHQGRSSSSGHYVAWVRIGDEDEKSDTAKWVVCDDSNISPVSEEEILKLSGGGDWHCAYVLIYGPKKIPRLDSPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8P7</accession>
    <name>A0A914H8P7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914H8P7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14834.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14834.t1"/>
        <property type="gene ID" value="Gr19_v10_g14834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="149"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14834.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38591" checksum="00C99E569E675B92" modified="2023-02-22" version="1">MASFELRNFGQISNVRLIILGWKRIFGYPFYEYSYLKLGLNNCSNECVYTEDKTFESSASVVLVHVRHDFSPLPEHRRPEQLYTMVSMESPHWSQWWLLARLPNNYFNMSISYHTDSTIYLPCDQLSEITSQTPREQIWSDREIQMQINKKQRLALQIVSHCDAPSGRDLITEQLQNLMELDVFGNCNSKSCDDACYQRELVTFFYLAFENTVCPQYVTEKFWNALRSLVVPVVLNRSVLNGTGIPDNVYIAADDFDCVQALADFLTALLGDSERYLGYFNWTKKYRRQWDNTKPSALCQLCQIAHKQMQKDKDGIQTVQLDKFWAKKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8R8</accession>
    <name>A0A914H8R8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8R8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15095.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15095.t1"/>
        <property type="gene ID" value="Gr19_v10_g15095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037493864" evidence="2">
        <location>
            <begin position="24"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15095.t1"/>
        </source>
    </evidence>
    <sequence length="863" mass="102881" checksum="915F958E41E06A98" modified="2023-02-22" version="1">MAKFWILIVVRLITTNSLEKAESVKLEELPLQTFDELFVDEWWDKDDAAEDLKTPTPTNFGQNVHHQIDPNTQSGQIEPNSTDQNPPLAKSDHSDNAKNGEEQNEPPVHKLVKLEQALFQLSRLFTLVKLEKALLTYPPVYACQVGTGALSIYPPVYACQVGTGALSIYPPVYACQVGTGALLTLRLFMLVSWKPACSCLPSWNRRSVKLEQALFQFTRLFMLVKLEQALFQFTRLFMLVKLEHALFQFTRLFMLVKLEPLFQLTRLFMLVKLEQALFQFTRLFMLVKLEQALFQFTRLFMLVKLEHALFQFTRLMLVNWNWRYFNLAACSCLPSWNRRFFNYPPVHKLVKLEQALFQLTRLFMLVKLELALFQLSRLFLLAKLEQPPVYAPSWNRRFFNYPPVHKLVKLEQALFQLSRLFMLVKLEQALFQFTRLFMLVKLEQALFQFTRLFMLVNWKPACSCLPSWNRRSVKLEQALFQFTRLFMLVKLEQALFQFTRLFMLVKLEHALFQFTRLFMLVKLEPLFQLTRLFMLVKLEQALFQFTRLFMLVKLEQALFQFTRLFMLVKLEHALFQFTRLMLVNRLFLLAKLEQPPVYAPSWNRRFFNYPPVHKLVKLEQALFQLSRLFMLVKLEQALFQFTRLFMLVKLEQALFQFTRLFMLVNWKPACSCLPSWNRRSVKLEQALFQFTRLFMLVKLEQALFQFTRLFMLVKLEHALFQFTRLFMLVKLEPLFQLTRLFMLVKLEQALFQFTRLFMLVKLEQALFQFTRLFMLVKLEHALFQFTRLMLVNWNRRFFNLAACLCSKMEQALFQLSRLFMLVKLEPLFQLTRLFMLVNWNRRFFNLAACLCSKLEQALDGAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8S4</accession>
    <name>A0A914H8S4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8S4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14807.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14807.t1"/>
        <property type="gene ID" value="Gr19_v10_g14807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037551039" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14807.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10511" checksum="F70657741EC3B58A" modified="2023-02-22" version="1">MVPKHFDKIFFICILSSLVPLAHGEGKESPEEEKERIEWIEGKINEYDQHPWPEAQRLKALRFKIVSDGNGYTAAGETAIDYTTLFPEFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9R8</accession>
    <name>A0A914H9R8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9R8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1536.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1536.t2"/>
        <property type="gene ID" value="Gr19_v10_g1536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1536.t2"/>
        </source>
    </evidence>
    <sequence length="464" mass="51893" checksum="5F9CBD3C08B52960" modified="2023-02-22" version="1">MVRTYTFNPSTQSSLSTSLPALPPAAVFAHSASIRRRAAPAPPPQLLPHHPTAFPATRHRRDLPPPDPQSHNRNASNISSSSGIGESSFSPTAASSSEHRQVVVEEERTTFIGIRSVLINGQRFFQPVSVPAMPSSSVPVEAVAPLLALSTVTNNGQNYQQKSQKVCAFPDFVVPPPGEGNSPWIRGNPQPKNGEQRDSHTWQQAFEAKTKAHFGATFGRESTGGWIETAKAAEQERHRMELLAQVEENRQQRIRERQRDWQMEERERIKDELYQQRMQMELEEERRREREKALLVELKMAKLAAAQRATEETLRAAKNGENPRGKGAPRGQPMPSDLFDSNGTATKQRQRSLENRTPEGRDQLEWWERKDRRKEMEKANGRGERPVQSPVIPAFSGGARGRRAASGDSRRSGESAGGRGHIRRPNGGNGGQTAHEPSTARRQRTLDTDSGRHIARRYNTDQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAN2</accession>
    <name>A0A914HAN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15609.t3">
        <property type="protein sequence ID" value="Gr19_v10_g15609.t3"/>
        <property type="gene ID" value="Gr19_v10_g15609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22084:SF4">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22084">
        <property type="entry name" value="GEX INTERACTING PROTEIN PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15609.t3"/>
        </source>
    </evidence>
    <sequence length="513" mass="60010" checksum="72E263DA2134F492" modified="2023-02-22" version="1">MEQQNITYYPTEIGHSQSNGDSRDQFHREHVAFHSDANVNFHATNDANFGTGTRRTAFRPGQVQQQQRQQHLVVQQSPTSIPQRISTTTIPASTAGQQTVHLQLVPQQVNSTIAGQQQQQRQQHIVVQQAPTSIPQLMGTTTIPVSTAGQQTVHVQLLNQSNRLTRRQTLQMQQQPTCSSNTLSNVQTIQQYGSPMLDSKFTIKNKLLSGIDKSSEKAEREALKRARQAEAARQRYHKLTPDQKKELNLKRTEAQKRKKQREKEVAELESILRASNDIVDDPEVLEQLREKRMRAKWAEAARTRYHRMSEDERRSHNLRRRMKQAKCEDNKEMVSTVDDETQRRMKEQNAKKAESARQRYHRMSTEEKKMYNQRRTEAFRRRRMEEEALLAMPIGRINGEALDRAQQIVIRNAKRAEAARLRYQRMTPEQRRAYNQKRYMPKRKRHDVDIMMSMDSPLGLEKMDKVEREEDEFDALSSLEREVQRRTHQAQQALLHRQRVVQQQQQTPNTPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBH3</accession>
    <name>A0A914HBH3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neuropathy target esterase sws</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBH3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15572.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15572.t1"/>
        <property type="gene ID" value="Gr19_v10_g15572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036769475" evidence="11">
        <location>
            <begin position="18"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="170"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="506"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="13">
        <location>
            <begin position="831"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="9">
        <location>
            <begin position="835"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="9">
        <location>
            <begin position="862"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="9">
        <location>
            <begin position="985"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="864"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15572.t1"/>
        </source>
    </evidence>
    <sequence length="1255" mass="140858" checksum="F16CA8F8A80B125E" modified="2023-02-22" version="1">MLWLIVLTIVLATIVLCVFCLRTGQSSSPAPSTEKESAEGAQLSTDANQSNPNVFKSIYSSFVRRKSLSMVDIPQLLQRRHSTVNDHHIPSQVANVAKSLFRYKDVYRRQRSIGVNREALPKPPNEFFEPNPLPEIPDDRFKPLTFLRQNLRILGFPPSCDINQSDIQVFIIEPREVVMKPGDPDDAIFVTLEGCLSVYITSPDASDKPIHVRRIEPGDFFFSPLSLIDILMGNPSVLKTVTLRAAVRTRLAKYSLLNFYNCYKQDPNTAAWVRPIQIIATRLLHVVLTTLHQQMGLGEELINKRLAPSSEKLRVKSRGQSLKAACSLTKPRLKRMSTEVEQQQPKHEQQIELAVSYYSEALCLSGDDALELIRPFVKLVYLEENQSLFEEGNSENPPALGVVVSGMLKLTQQARFTAFEDSGQDAWTALIHPKELIGGLQILTEEPAFYTVKGACQCVVALIEKGDVDRLIEHRPSAILPIAYSVLRRVSPFVRAVDFALGWVLLDSGEAVYRQGDFSESFFMVLSGRLRSVSHKVAIEEFGKGDVLGLVDVLQHNPRATTVLAVRYSQLARIPEGLLNFVKMQYPQVGFRLVRLLGQYYAGRSHFPTISHPSSDPLTQRNLHTIAVFPASTDVPLVSFTCELYHALSATTRVLRLSSKSVIERLGVESVMERDADFRLMHWLNAQEDTFQLLLYECDYTATNWTRRCLRQADAILVVAFGDKMPPEKHVIDDHLKMSHDGLRSRKELVLLWRHDVFCPKGTFEWLKGSWFSGHYHVRAPDRMFAGVNNPGNNEHQILEFYESNVFPFSVDIHGDFARLGRIISGNAVGLVLGGGGARGAAHVGVIRALRQNGVPIDMIGGTSIGSLVGGVLASNPYEQDGFEHKTHFWFMGMGSVWKALMDFTYGYVARFTGSHFNSLLMELFDEKHIEDLWLPYFCVTTDITDSEMRVHRTGPLWRYVRASMSLAVWLPPICDSEDGHYLLDGGYVNNLPADVMRSFGARTVIAVDVSSADDKDFHNYGDSVSGVWAQLRALNPWSTKLRILTGQEIQDRLAFVSSVRQLEMVKKAPYCNYLRPPIAAFLTMDFAKFETIKSSGYRYAAEIVPNLVMTSAHLKTLISHEKWHDRLRSGSVYRPDSRNNFHGGSIVDIAAQLSRIPPKHCRSVDFLNRIVDDDEEEEAGADDEADFPESIINKIKSSSNSPAQWKSPSASPTDQKAAATNSSEEPKTVDFSLTTTVQLQLQSLEEDEVFEATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCB0</accession>
    <name>A0A914HCB0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g16198.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16198.t1"/>
        <property type="gene ID" value="Gr19_v10_g16198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF15">
        <property type="entry name" value="CC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037892522" evidence="2">
        <location>
            <begin position="48"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16198.t1"/>
        </source>
    </evidence>
    <sequence length="1325" mass="142601" checksum="48B6B8728812CC67" modified="2023-02-22" version="1">MMTTVTPSSNAAAPAHFTTTSRVPPSHMHAALLLLLLLCSSVHICCSSNTVPSNAGISTGELCGAQGRLLLMPPNQTVLQCQHDSDCLPPAACDARSRVCCVQPLDQEAPPVGCPKGTRQLQNANGEWLSCEPTRPSSCPGGALCYEDSLDGQYRCCGKDPGEGCGTGQRVLRHANNGSVQLCVPGALPECPGNAVCEWSFSIDRFQCCEPDSGCPAGEVPMFDINDEVLTCSPQRPTACPQAAHCRFNFWTAENQCCAAARQENKISSSDGQKLILYNKDCPSGEIPYIELGTTELKHCEDTMDCPLEYRCHRRICCGPTGQCPRQAEHPLHDDHGNVRLCLLMRPEVCPDNSKCRETLHALSGTPTGQRVCCGVMASFFECAASAGGQPFPTAEYPQVCEMDNPVQCPQDTICQASSVPGVSICCTGGDVQRRALCPKGWSAPDKLNIFCHPTIRGSCPSFAACLLSPVTQQFVCCEPGDDDDEELMHHHLRKHHHPRTRQRDHSQTERSVSVHSLSCPNQDDRMELLNNGNARHCTIDGRVPCSDGFICERSTENARVAVCCSAQRAPSRRVQRPQHGRDEPTYRCPSGAQVPVLRNGQNVFCDLGAQRCPSGSSCASALNAFGMMICCRNARQTLPLCPVGMQPETSAIGYVPCDFLAPDQCSEGYQCVHSRDDPETNICCSRLRNQPPSPATTPICPNQQILLRDGASPRYCSPRQGISACPNGYQCEESLVQPNVFVCCSIPALVMCPQGFESSLDLRTQNPIRCSPMDVSMCPAEAQCLEAMNRANEFLCCESTEPGRVCPLPGQAALLRPNGRPEECSEPGSPCSKSSYTCQLSNVLNRYVCCGTPTAVVLCADGRETYQQEPGRVVQCNPINWPNECPAGYECALSNRPGIHVCCRRLPAPPNPNVPNTDMPPPPPLQPPTQQPPASITFRPPVDELTCPVGWSAYEDQRGAHHFCQDALDMTCPHGFSCAQSSVSGIFMCCRLASSIQCPRDYSTLMVNNNPRLCSLTVLRRSVVTYPGASGIVPSSLATRTATSAADTPHTCPNGYTCMQSSVPAVYVCCGSSGLGIAGGFGSGILPPAPPQPPAVPAPLMPALPPGTSGLITTGQAGQPYCLDGQIPAYLGQLMRYCVMLGQASECPPSYVCAMSNRAGLYVCCHPFPVVRRTSMAQQMRDYSSLTKPIIAHCPDNREPYRIPDTGELLSCGPDLPDAQRQCPHNFVCKRGVQQLRAKDTPRVCCSPIAFCPGARLPQVDTRTHQAKRCLLDAVHSNDRASPTDDASRGDHGQGTAAHCTPPFTCQPSTVPDIAVCCKSLAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCM2</accession>
    <name>A0A914HCM2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chondroitin proteoglycan 4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCM2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16280.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16280.t1"/>
        <property type="gene ID" value="Gr19_v10_g16280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029153">
        <property type="entry name" value="CPG4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15481">
        <property type="entry name" value="CPG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036811188" evidence="1">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Chondroitin proteoglycan 4" evidence="2">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16280.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24810" checksum="95EE5C43176E4CC5" modified="2023-02-22" version="1">MHLYDNKFLFLLILLNLWPFATAQQAASSMSAGLQRCLEPMTRLEKTVSFMYRYYESVCEKLEWAASCAQSCQAEDRGAFFQYTTFYRIHCVDFEEELEELLPCLREAAFKADVVCRERCVPKEPMDKLSAKTERQKSLCKNVECSTLCYVQELSAGCPNAKETIIRLNVRIADEMRRLTRDSDFEKLSVYCQRVHDGDYLRKRMHELTKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDT9</accession>
    <name>A0A914HDT9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CLAVATA3/ESR-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mimics host plant CLE extracellular signal peptides that regulate cell fate. May play a role in the differentiation or division of feeding cells (syncytia) induced in plant roots during infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Host extracellular space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLV3/ESR signal peptide family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDT9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16099.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16099.t1"/>
        <property type="gene ID" value="Gr19_v10_g16099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043655">
        <property type="term" value="C:host extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044962">
        <property type="entry name" value="CLV3/ESR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36349">
        <property type="entry name" value="PROTEIN CLAVATA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36349:SF2">
        <property type="entry name" value="PROTEIN CLAVATA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037333125" evidence="14">
        <location>
            <begin position="22"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16099.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19020" checksum="7DAD1038F77741E6" modified="2023-02-22" version="1">MAKNAMLCLLILSVVLALAFATNKKGRTSLTVALAMSSRLGGADATRGGGAVYGRNLKSNQLPNNNWMAPPPPMAMRSAKVYDSKHPPAEYLKKFAQDFRRKTGTHSQRHQEETTLEQEKRGAPAGPDPIHHQDTTFEQEKRGAPAGPDPIHHQDTTFEQEKRGAPAGPDPIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFF2</accession>
    <name>A0A914HFF2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16867.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16867.t1"/>
        <property type="gene ID" value="Gr19_v10_g16867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="430"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="944"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="1168"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1724"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="872"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1975"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1975"/>
            <end position="1985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16867.t1"/>
        </source>
    </evidence>
    <sequence length="2046" mass="231538" checksum="C7618773DE3960EC" modified="2023-02-22" version="1">MNALNGCDYFVIRSASLNDVGVLEIPPPLKRQQIALKRNTRLFRGKYKLLLGMDDKNLATKNARGFSTFLSAERAVQSLEHFLQTDNDFDGFWFGPSFLDESSQYFEMFPLIIAKLNSKLKKRNLRHKKKIVIGISAEHMNLIGGWGQENSAVDLIYLFASKEKALSLFDMEKPIIPTTSLWTQKEHLVNSKILVNKTIIGLNVMATSFEHNKMSITRERGVRQFSTVQTCQLIEERGHVLYDRAGTTILLNKTNIVHFIWPEHETLKLKIDWIKREGFLGIGLSSIAMDYDKFKTCGLNFRFPIHETISNLIGGRYAELMRPTAHSAIVYVPNYNSQNDNCHNGCIESDFNNIKMEQQQTYAIQKSSWHKSGLTCPTRSIERHYRSVTNGNSELMRNGQDDQQSIDCMEICGVRDLKLQPERSTSNFRTIGGITFSTLFYPWVVYVEAIKQCTHTKPMFMRCTGVLISMKHVLTAAHCVKWDRMLLAGCLGFDDPSFVIGFDYINPQELSVFYGSHDISNAIKSKVAKISVPELFDSTEAEPRAYDIAIIHLEFRLDRLRDGVSPICLLENFNALNGEMGSTVGWGAVDRLEPGGDNRGSLAILIIAPVYPSPMTQQWRRPLQKLKRVVNSKRDTQGHLHLQAILAAQQKQFADLLAKVLPVAPSANNSDLFSQINTQVPQFNYDPEADETFSLWWDRFGSFVEKDGKAMGEDMKVRLILGKLSATEYLRYEQQVSPQKPAELGFQPTILALKSLFGDTKSVFVRRFEVFQLCCGPTQSVMEFGAIVNARCERADMTLTKEEIKCLIFVTGLSDAHKDLRQECLRQMEKARKAIPPKAITLEALLEECRAIQSLQNSAAALAPAVHTIQVRPQRVKESPKKRYQGKSADRPNLGRNFGEKWDKKREFVPANRHEINNSPRLKCERCGNAHEIRRCNYPPNVQCFGCGRVGHIKQICRSSRHETRVQSHAVFSTFSVAYSNREWIWIQLHVNGRPLKLAADSCSHLTIIQRPLWISLGEPKLNKVGKRVGSFSGHKLQLLGSFNCHVQFRNVDLQLECWVADTDAPSIMGLEWIRPFEQATQQPVATTLSRQSVPTVLAIQSTEDPQDLASQIKRAFPQVFEPGLGLCTKTKATLHLKQNAKPIFCRARPVPHGVQDEVDRELERLEAIGAIRPVDFSRWAAPVLAVRKKSGAVRVCIDFTTGLNEALELNRHPLPNTSDIFHALRGSKIFSQLDLRDAYLQLELDEPSKPLVGINTHRGLFQYQRLPFGVKSAPSIFQKVMDQMTAGLPGVFAYLDDIIIASANLADHMSILFKLFSKIQDYGFRIQLEKCHFLRTDLKFLGHVVSSQGIRPDPDRSAAIREMPPPHDVSTLRSFLGAINYYGRFIKQMSELRAPLDSLLKKDSPWSWGKEQQSAFDKAKQILLSDLLLTHYDPTRPIVVAADASQYGIGATLSHKGPDGSERVVEHACRTLTTSERNYAQIEREALALIFACQKFHRMIYGRKFVLLTDHKPLLAIFGSKKGIPIYTAARLQRWALTLANYDFTIQYVKSENFGQADVLSRLVASHRSDEDHIVAHTHVDEEHYNVDDVTEYVYMANLESLPVSSEEVSEHTGTDELLQQVVGYVRSGWPDKCPANDLMSFFQKRNTLTTVGGSLLTGNRVVIPQQLRRRVLVAVHFSHPGVVRMKALARSHVYWPGIDHDIEHMVKQCSECQSAAKLPPKAPLRPWPTPNEIFGRIHVDFAGPCTDGRTYLILVDALSKWPEITEMPSTTARSTITALSRVFHRYGTPVELVSDNGPPFSSYEFQQFCNQNGIKHSFSPPYQPHCNGQAERMVDTFKRQAKKNASSPAQDWISNFLFAYRTTPSQLLQGLTPAELFLGRKLRTPLSRLQPSREKNVEVHRDQYREQMRKQYGRRHGAVDRHFEVGSPVLTLNYGRMGRPAWLEGKIVDGKGLVWKVRLPTLGITVTRHSNQMRPFTPCQTENAAGFNTPRASTPPRVQPPNGSPRPQVAQREVPAPMAPIPISRTPRPQRQRKPPDRFSPGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFM8</accession>
    <name>A0A914HFM8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HFM8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16715.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16715.t1"/>
        <property type="gene ID" value="Gr19_v10_g16715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="37"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16715.t1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47007" checksum="83FBF3A41E0F04BF" modified="2023-02-22" version="1">MPIPSRARVYADINVNRPREYWDYECHQIRWGNIDDYQLVRKLGRGKYSEVFEGVMLPNEQKVVIKILKPVKKKKIKREIKILENLRGGINVIGLLDVVKDPVSRTPALVFEYVNNTDFKQLYQTLSDYEIRYYLYELLKALEYCHSMGIMHRDVKPHNVMIDHEQRQLRLIDWGLAEFYHPRQEYNVRVASRYFKGPELLVDYQCYDYSLDMWSLGCMFASMIFRKEPFFHGHDNYDQLVRIAKVLGTDELFEYIDKYQIELDPRFNDILGRHSRKRWDRFVHTENQHLVTAEAIDFLDKLLRYDHQDRLTAREAMDHPYFYPVVEEHRQRAAAAAASAAAEATSSAAAATTAATTGGHANAANNVTNSVCLGAAAGGGGGGGGASTPTNGISPADITSLNEQQQQLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGG6</accession>
    <name>A0A914HGG6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17279.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17279.t1"/>
        <property type="gene ID" value="Gr19_v10_g17279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="257"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17279.t1"/>
        </source>
    </evidence>
    <sequence length="569" mass="63554" checksum="41F63265CF0AC264" modified="2023-02-22" version="1">MTTVSDSNNTLRAQSLSHSRQTRKIGSSEREHRQKLPASSGIAFEEFKSTQQQQHLVLHLPEGGFASSSQQVVHQQHEFASTASPIAHCYLIDQQQQQQQQQPTLFSAHSSDTQQPQAQAVPVQLLNLSDGTAAFIPVNGAAIPSSSFIQLGDDNHHLLQTSDGQTIELVPADGFRFTDEVQSAKDLSPEGSSSCGSFHQLGHYPTTALFTAAEAFSPQQVEPVYVNEKQYARILKRRAARAKLEMEGRIPKQRRKYLHESRHRHAQNRARRAGGKFDSGQPRTTSAASIQWSEGGGDPEGFKKERSDLRAVKLLIRSVMSGYVGIKFCPECNNMLYPREDKQIRRLMYVCRNCEHSEPADNPCIYVNKLTHEVDELTQIVADVIHDPTLPKTEEHPCPKCKNLESVFFQAQSRRAEEEMRLYYVRHFLLLSPKFHFRFRFVVFDMLRTRALDAFLGQVVGSAVAGVILFNKDGLTVSKTVGDANRPFSGNVHSALLANIWETFERQGVRDELKEVIIGCDRGTVVLTRVASMLLAVLGTEEAPLGILLVKLHALVEQLKVPLSAITPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGP3</accession>
    <name>A0A914HGP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17008.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17008.t2"/>
        <property type="gene ID" value="Gr19_v10_g17008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17008.t2"/>
        </source>
    </evidence>
    <sequence length="141" mass="16177" checksum="43C02B88F1A9DFFC" modified="2023-02-22" version="1">MSENIRTGKQLTPTLSFHFWMVFASALTAYWSYFEIPGFAYMLMAGNIANVEALMIALRCHPFLKRDAISTLRRIFVFKRPTNRVHDDGGQQTTKCAKNNNRKSIAMHDLINGKALVVSSMGQDIYFDSLWKYWNEGKCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGY1</accession>
    <name>A0A914HGY1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGY1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17261.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17261.t1"/>
        <property type="gene ID" value="Gr19_v10_g17261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038045617" description="Lipase" evidence="11">
        <location>
            <begin position="28"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="12">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17261.t1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48575" checksum="2F351D647656C555" modified="2023-02-22" version="1">MCCANFVPRGVLLLILLLSLFLSPALPFPSDQRLPEESLTTPELIAYWGYPVEVHRVTTEDGYVLQLHRIPFGRSENSSVLYSSPRPVFFLQHGLLSSSADWVTNLPNQSLAFILADAGFDVWLGNVRGNFYSDAHVNWTKLERKFWKFTWDEMASKDLPTMVAKTLKVSGQNDLYYVGHSQGTAIMFAKLASENGTFPKKIRKFFALAPVASVKYIDGLIAFLGRYFGRDLWALRFVFGTHDFLPHNWMTTMFARIVCGLSWRNILCENVVFQIGGPESNQFNQSRLMVYAEHTPAGTSTWNILHWAQMRNSGKMQKFDFGSKETNRQHYGQETPPVYNLSRIAVPTYLYYSEADWLADARDIEETILRSVPPQFIKKALKLPDFNHFDFVWGMLAPDKIYRQITETAKRHEKSIGRRHFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHS2</accession>
    <name>A0A914HHS2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHS2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17285.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17285.t1"/>
        <property type="gene ID" value="Gr19_v10_g17285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036825120" evidence="4">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17285.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20236" checksum="17270D98E9136BF1" modified="2023-02-22" version="1">MSRKIIHPLTPTLTLFFFYLFVRTSSSNVETSLPLNTSRILSTTPTTTEFVKSKVEEENARLSAALSSLNSRIVQLEESLRRRGDSAELSTFFPIISAQGVAFSFPCILLTVLTLLLLIITLLILSNILMIRKFSRGHNEEGEAMGQAKQREKGLDMDRKGTPRGSSMKQQEMVQLVKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK79</accession>
    <name>A0A914HK79_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17737"/>
            <dbReference type="ChEBI" id="CHEBI:27910"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46741"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:23986"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A914HK79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17379.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17379.t1"/>
        <property type="gene ID" value="Gr19_v10_g17379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17379.t1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52091" checksum="C9B06561A960E89E" modified="2023-02-22" version="1">MSFRSHRRRSSGTGGNLLSRRSSMSLRDYEQLVKKRQRLSDWVLFPLMLGVPPFIVLFHSQLTFTYHQQALFEHILDQICSSVPPIVLLLTIQLQLFFLWYLPARDVQVTVEEGEPFATRFTGFESSLLVCLLYILGALLGLYPGHLIFTHWVGLLFWLSLLSIFTAFLLLFTPRAPPVSPPSPSTDDSSISVSAPLSSADPPVASRTPSLISQFFYGFHLQPVLLNVDVKSFLTIRLALTFWALFLISAQFVHRRLSNANFSPFSPLITTTALQLLYIVRRQWAGFYRIFSVLVLLPTVYLVPVTLGAISVDVPQRPTLICAGLFLFGLLCQYLNTATDLQRHNFRRSNGDLKIDGKDPFYICVRFRKKSGESAVALLLGSGYWAMARHPNYTTEWLSFLAWTLAWTQPFAFVPLASLTALFWIRTKRDELRCLALYGHFWTQHCARVPYLFFPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKD6</accession>
    <name>A0A914HKD6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKD6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2133.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2133.t2"/>
        <property type="gene ID" value="Gr19_v10_g2133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036859385" evidence="2">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2133.t2"/>
        </source>
    </evidence>
    <sequence length="175" mass="20071" checksum="4731824494F644A7" modified="2023-02-22" version="1">MSSSRISQVLLLAAVAYFVLLEAKIDVYVKDPHKTPTSSDDDRSNVVLDANALQKHQNDDDVLVQHEVNGSKKHLLLKVRGHRLVEVYRERDGKKGHKKHLLLKINTPNHRHKYVRDEIVKSRENDSAEKKVSVRVNTSREDDKIIKNRENASAEKKVSVRVNTSREVEAHKNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKP1</accession>
    <name>A0A914HKP1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKP1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2360.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2360.t1"/>
        <property type="gene ID" value="Gr19_v10_g2360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037458593" evidence="1">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2360.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16348" checksum="33A60105A8A7508B" modified="2023-02-22" version="1">MPHNKLLFFIFFITLQQNFTNITAKLLTKVQLEKVLSRDDLLDSSKLVDQLRLIEEAHLKAAQKFRQVREMIQKYRQDGICDYCELIHKKTVKVSENFSELFLGFAIMCARINDVKEREYCIGHVNFLKQQVSSFLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLL8</accession>
    <name>A0A914HLL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PHD finger protein 14</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2478.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2478.t2"/>
        <property type="gene ID" value="Gr19_v10_g2478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF158">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="308"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="772"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="682"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="610"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2478.t2"/>
        </source>
    </evidence>
    <sequence length="893" mass="96876" checksum="F5A2CDB5A11AC8D5" modified="2023-02-22" version="1">MDKERHNFLSGAVAREPGKRQIKPNAAFFDEQQLLPCGEDDDEEDEDVIFPLSNESRCSDDDESGESANDGDSFSQSADERQSDDSGGNSSDDEASDTDNNIDQKRDTRDNVDHNHKIAAVIQLDAEGGASTSNNNTNNLITVQQQQQLLKKRKRGGGKNNKKINGLMGHQNDDGTKQETVADPSTEPADGSSEAQLCAICLNLRPADHCGELIQCDRCALSVHELCYGAVVVEDDGGGGSGEHQQAAATPNNSSKHQQQEEFNNQPKNGHLPPIASASATADTQSVVSSASTEPWFCEPCLFNVADVPHCELCPSRYGAFKKAVSDAGGGWVHVLCAAFTPGVSFADAEALSAVSWRGIDTRAFGRKACAGCCSSGGRTPTHALGARTGITVQCDAGMCKHFYHVTCAQRLGLLIDLESEAHRHHRGGGIFGTSNNNHRQQNGKSGCGAVAVRSTETVHSEVGYLYCKKHAPKDVSVLRMKNAYAKFVESEERRMVRWNRVSLDARQERKRAVQLRDYQQRVRHHETTTAAVTTAPTQKRAKLLHANSRILNAFSEMHELLGFDGEQFAGEFSAVPAAQLPFSLTPTFSKTFVSYMEHRDLVGLPGEDVRLAQLNRELAQRQRQQKEAERKLEELRNVHGDEQRAHADQQLLFEQFRSVLIKLAPNSPLLLSAAEKLPLETNKKMPVKRRRRSSKSPDGAKSPEIMPKTTAPSHPIRQTKSIQPNNTMAKTKTDPVADGNNNAGGDAAQTVSKTATKSVVNAAALPISPLSLQCHKCKKATDAHRLVYCDTCKCHYHIGCLDPPLAKMPAKSKFSRFECSNCACPSETDGAEGEAEKGEGGTHARKEEVSNKAVARLGAAASLASLDGQNGVCHQNEPGPSASIVLPQFVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLZ5</accession>
    <name>A0A914HLZ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLZ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2721.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2721.t1"/>
        <property type="gene ID" value="Gr19_v10_g2721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="418"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="817"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2721.t1"/>
        </source>
    </evidence>
    <sequence length="1229" mass="140325" checksum="D00629977A008753" modified="2023-02-22" version="1">MMMDPGSRTASSVPPGTSASSKGRPTTGTTPIEYTVKQMADTFSNRNPLAMNDDERLIHYQQEFKRYQKLLTDEEERPLNVHLSEQTTNALRDTLHKATSTPKPHAQQQQQRVSLTKRPKRVARRQPPHTTVALSSSSASSSSSSTDSGKSGEGSSQNKSNASSTFVDCQEQQQQPQAATSSGTAPPPEQSSGSDALLLEQAEAKREAALAYAVQNPGLLRLGGFDGMQILRVSQGAYRPVKGSNLATLLNYHFVDRHQRVSPAKPPPGYATFLGHARDDLQMWRLLYPEKATEHKSGSTFSRAHLQRPQQKQQPQKMGGRGALLRFKKTKSKQRAQPRTLHENSAEDLAKKRERHVERVLDPLYKDERSSACFTSVEPLLREARRTHSTDNITRAEVRRYLAGQRVYTLHRQAIRRFRRLPTLASGLHTDWQADLADFRRLRHHNHGYTYLLVCIDTLSRQVFVEPVRSKQSTNMVEAFKRLFRRCGYIPWRLLTDKGREFTAAVVQRYLREEANARHHCMETSPLWHAGMAERANRSIKERLYRYFTHQGTQCWTRVIQRIVTALNESPNSSIFGMRPCDVTFENAERLRRRLVAQADAQRSGRAFSVPRFRVGDRVRIERHKHTFQKGYLPRFTEEVFTVDQVCTGRRPITYKLRDTDGEPITGLFYAYDLCRVLLHPHGDNNRNTDNSNKNNPDEREEERVYAIEKILKRRRQKSGTEYCFVNVAVKHQCGRKSDQLFRVHLPRKLQFSAQWSVGLAVLIYPHTWPSLGTSEPQFVRVEWQTGEHVRIPVPAASVSNPQELLESLHRALGEGSDQLATELRSLQMEYHRLVAEAEQLAATEAEHLLKNEDEETTKKGVPSASTTRNISKPITIPKKETTDSSSSSNVSLKEKETDAVQSRREILRRQVYARVLDELLAKKLTERERTLLTTHLPIGLELWIHSYKKARMACQFNFDSSRQRFRLKLDTRRIRLVELSAQLAYILGYSAPVLAEPVNISRYPPDMKGGVSTFYVYTPGLIEPVIIGDCVAPVLRIVNIRGSSDEVVEECYTAVQYHKLMVKEISEIFVEIRTSSGALMPFQCESTRDVFLGSFPADLIPPIHGQTMYPHCMVVNTDTSQEVGTHWVALYVQTPSIVDYFDSFADWPPESAEICTFLHRFKHVNRSGACLQSDRSSACGKHVIYFLYRRCRGWSLQQIVQHLRDCKTTPDRLVTAFSRKFIFGQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM97</accession>
    <name>A0A914HM97_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2652.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2652.t1"/>
        <property type="gene ID" value="Gr19_v10_g2652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000023">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF495">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="811"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="887"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="1234"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1420"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2652.t1"/>
        </source>
    </evidence>
    <sequence length="1480" mass="166615" checksum="57D5D80149F8A96D" modified="2023-02-22" version="1">MKNLTKNESSLEEVKIRVIYQADNVPGHAFIVVGDYEYDFMTAGARRRIFRFDIANKLEENDKERPQAFKGLGLFVCPLKVEQSFFKMGSRFWFKESFSPSKANCLDFVFNFVCALFDGDCPKKEIWPDNFVNFDKDMFRDYLKLGDRRQPASALERKPISLPANDDHNCVLKDHHLEFRITNFKCDVNDEGGICANFVLSHFTGLFDLPVLLGKELKNKILVETKPKKVWKDGENIHLVAVLKAYSCKILGNLSMSSVGHLILLNKTTKKFIKTKNVCHSHFFGLINLDEIIGHIVEKLQSKIQKTRLYTQMFSNIFLFGITCIGGCLLIKAQQTMPGNSMLAFTTSATPLANQTVIKVAMLIAQNDTDYGLARKNSALRNSGGAIPMALEQLWADEILPQNVNFSFQWHYSNCNEANALGQSYQYIRDFGADAIIASCMDVPPMLGHLAANFNIPMMVWGQSMASALASSNNVTYPSLLNIVPNYKYMASGLVSLLQYFNWTQFAVVTQSDIGAVSGGCDFLGSDIDIALSAQSVVNVNYKARIFDIKTSDTNTIISALQQRARIVLLCFDDIKQLRTFALSLFDGGLTKDYVYIIPDNDLNLSFNLSKLPFWVQSWRDEDAKVIGRLAFWWHYDITLSALSNRNYYGFYERVVKRTRDWPFYCPESDCGSVTNGSLNSILLYDAIYNYGMALNESFKQFGVRPEIYRNGSLLAVNNRKPFMGLTGYVTVETDQNTRVFVLSRRNSDAKGNSLEVLMQLAWVNGQLNVTMRNASSPMWASRAGIIPPAVPTCGFDGKGCTVSVFDMYKGYFVTGIVLFVLLIGGSIFIFAGLIRAKIVQNRRSNLHWQIPFALLKRSKQKHFERETERSRHSLRSNQTNISSLTHATMDSLAQSKIFALYTFNGDKCIVRTYGLKSLAPPLSVAELAECRNMRLFDHENVNRFLGLCLDGPNVLAVWNFCARGSIRDVILSENAMVKDVVFIQSAIKELCEGMYFLHNSALQFHGRLKSSACLINERWQKTQTKDLLWLSPEQLREMGDFDENVDGSKQSDVYTLALIFTEMVNMSPCWENGGAAEEEGEQAVHLSGEPRRGRSTVTRARNAEEIAYLVKRGGLFPLRPSLRPAFDNLNPELIHLIRDCWVEAPNERPTIEKVRQKLRQMNAGHSVNLMDYVFGMLEQYANKLEEEVQERTRELEGEKRKSDILLYRMMPRQVADRLKLGQSVEPEHFEAVTVFFSDIVQFAALSSQMRPLQVVNLMNELYTTLDAIIDEHDAYKVESIGDGYLCVSGLPKRNGNLHGKECADMALEFMKALSDFRILDLPNERIRLRIGLHSGPCVAGVVGLAMPRYCLFGDTVNTASRMESSSSPNKIHISKATHTLLSANFDGYIMESRGEVIIKGKGVMETFWLLGHAENGALPANNAQQDRQPVTKADDDDDDGEEEMYRNYKQSMELGTSAAGDSGGVVVGGGYERGSGIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNJ5</accession>
    <name>A0A914HNJ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNJ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2436.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2436.t1"/>
        <property type="gene ID" value="Gr19_v10_g2436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037018596" evidence="2">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2436.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15395" checksum="E1370F5CF039D738" modified="2023-02-22" version="1">MFWILFLVSFFATNSIDKTEFVQLEELDDLSLQTFDELFVEEWWDKDEAEDLKMPAPTNFGQNVHHQIDRQNTQIGQIEPNPTDQNPPLTESDHSDNANSSENITEDERKRGKVNLAKPNQTKNTPTANERNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP93</accession>
    <name>A0A914HP93_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP93"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3147.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3147.t1"/>
        <property type="gene ID" value="Gr19_v10_g3147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036812147" evidence="2">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3147.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22969" checksum="043AA84C192C837E" modified="2023-02-22" version="1">MEEFWILILVSFFATNSLDKVESVQIFDEIFGEGWWDNDKAEEWDKLTLEHNFHHQIDRQNTQLGQIEPNSTDQLGQIEPNSTDHLGQIEPNSTDQNSPLTKSDKHKTAAKELGLNDRTIYKWKRKLGQTKPKHKYSHSEQNELMKRYYKIKDQNPKNSDNNIAKMLKIGKGTLVKWKKQFELQQFHPTFVDDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRG9</accession>
    <name>A0A914HRG9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRG9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3254.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3254.t1"/>
        <property type="gene ID" value="Gr19_v10_g3254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037161715" evidence="2">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3254.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26880" checksum="E22E9A4F7C7F53E6" modified="2023-02-22" version="1">MEKLWILILVAFFATNSLDKAESVQLFDEIFGEGWWDNDKAKEWDKLTLEQNALHQIDRQNTQIGQIEPNSTDQNPPLTESDHSRQIEPNSTDQNPPLTESDHHSVQIEANSTDQNPAHTESDQTDNAKNGKEQSEIMKKITSNKKLAEEEGKHKTVAKELGLSFVTIYNWKRELGQSKPNHIYGHTEQKELMKRYYEIKYQMPKISDDEIAKKMLKIGSATLKGWKRQFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSG6</accession>
    <name>A0A914HSG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3540.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3540.t1"/>
        <property type="gene ID" value="Gr19_v10_g3540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3540.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14088" checksum="A64E2AE26B91E770" modified="2023-02-22" version="1">MLNCIESIATLILSIGAIAPHITGFSLGVQVPARRSEAERLYTFLRGYVVNCQHFPDFPHLQDLHLDDNSEDYLTMVLEHSRQLVYDCVHAPNATVQEIKSLGLMMSARNADLTTHFRIGFNETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSV9</accession>
    <name>A0A914HSV9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSV9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3903.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3903.t1"/>
        <property type="gene ID" value="Gr19_v10_g3903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3903.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37213" checksum="950AF3EB02C280F3" modified="2023-02-22" version="1">MLIILSDHRPTRPPTSPAGFDANPAVAASSYGAIDLQKGHVGFGIHCDLNLLRPLSRRKDVQSNSSEQLQDQEAPDWRYLLQQNGILDDQLTEMARDMDEDEPFIDELSDKANYKPPPPSPAHPTFEKTYSRRFISPSVEFGVDDQNKTQKLEGQSGSLANVYRKIAKFVQKLAKTFVMLKHLLMKKGTIGSEIVAKINKAIKIMAKERGISLEKIEKFNSKMELREIVKNAAVVWSETARNKHYVGNGKENTQKMVELWQLIRKNEEFINYLNKNQLKEAKNQSQKRRAKRTDPLTAAAILLVVACFVFFFIWLGIIWIADWLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT61</accession>
    <name>A0A914HT61_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT61"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3735.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3735.t2"/>
        <property type="gene ID" value="Gr19_v10_g3735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3735.t2"/>
        </source>
    </evidence>
    <sequence length="123" mass="14047" checksum="582B0E2E43BC4B96" modified="2023-02-22" version="1">MPSSSHILLPLLFMSVFFIYTSTSLLTYNFNQPIQLRRLLKMDPRRQMALIRLSDSMKRYEPSQMFVDLVDAQSAQNIHLPLQPPKGQQMAVVDSLAPSVKKWGTFADTVYWSGQKLIAKDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT65</accession>
    <name>A0A914HT65_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT65"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4237.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4237.t1"/>
        <property type="gene ID" value="Gr19_v10_g4237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF11">
        <property type="entry name" value="PROTEIN CBG21204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="302"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="499"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="598"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4237.t1"/>
        </source>
    </evidence>
    <sequence length="859" mass="93551" checksum="198D1DAF51364DDE" modified="2023-02-22" version="1">MVRGTFRPRGRGDLLGGGQEQKEAGETAVRTLGGQNVRLGEWPGAEFEEFDEEKEILLDLELRKHRMSSFFHILAESAFCLILAESAFCLILAESAFCLILAELEFWPLWLAESSNGGTTGRMSIMRGSPKHRRALLVTISGTFQILLPPFPFLPTSVRASPPAAAQVGLVIKRQIHAPICVGMAVSCSSSSSSSFVLVLLFVVVLLLFLPYASVDSSSSHLSRTLPASAALPSLSHNLRHKSIAKLTTASPAVGRQKPNLAVFSYGASSAVIGEQWGNETGEELLGNGQMLASVPDLSDPCFRRYANSIIVNAQPFERRSSISLINCKVQCLRSPVGVYSCRSFVYDNLNQVCDLFAHVGDQSPAKLLRFKTRDYFEPTAAIHCALDGNEPLKANVPLSPVAPPLMGISIKSPLSSPGDASFSTMFPLPPSPVPPHLPMKALQTTPPVMVGPTGEQTDEEEPPRQEPVTVKGKEDGSGKARNGMETVGTATGEQPKECTASQVPRFLRTMDFELFGFDESRIGNVRGAEECASACINKRASNGAGVKCHSFEFTAARSDCTFSAESAVPLGNGQLRQRPGTDYFEHICVDRLLANQCQPSVVPGFRRFPQMILVGFAETVVDSPSLQECFDNCLNSRQLYGFVCSSGMFYFEEPQLNCILNTEDRKSQPELFTSETSDLVDYFETGCSAGNRTIGAGNGGRQRDDGMSLRKQDFVGPRRHREPVPKMLEASTTTAASLPPSTSSHPPPSVPSFSSYKGAIWTGWTRCAGKGRWTTIGIQMRQKICGPRLCGKEERQCNLVGTTPIDGDGLRKGTEGTKSAVPKGESRRRDFHPPAVGHYSQRGRMPPALLSFLWRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTQ1</accession>
    <name>A0A914HTQ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTQ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4373.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4373.t1"/>
        <property type="gene ID" value="Gr19_v10_g4373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF74">
        <property type="entry name" value="ZINC TRANSPORTER ZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4373.t1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43057" checksum="447EA840B59CAF2C" modified="2023-02-22" version="1">METISLQVLLALAMFATTALAGLLPIKLLHVITRRKDEDERQGRRSDYILTLLSCFAGGVFMSTCFLDIFPHINENYARFLSKSQWSTDFPFPQFFVCCGFFLVYFLEEICLKVFASTKKHGQCHDGHSHPHANIEGSKSHRHGHGECLNEPLKTNGGEEKGLKAGTNERQTRSCSSSVPLGGDESDSCAHSVIPFKQRSMSVLTHEIVIDESLKYISTNGHDHMETTFLRSLTFAIAMSFHSVLEGFALGVQDNNTGILTLFVSLIIHKGIEAFSVGLQITRSNARRLFMVILTVIVYALMTPFGSLVGVLITNMDIDELVKDAIAVVLEALAGGTFIYVTFFEVLAQERANDHSNLVQLGAIVLGFCVICALQVNEQFSGSRDSIQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTV3</accession>
    <name>A0A914HTV3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH CENPB-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4413.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4413.t1"/>
        <property type="gene ID" value="Gr19_v10_g4413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4413.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28049" checksum="C190405806F6A87D" modified="2023-02-22" version="1">MDSRIDSTPTSSEKLVVCDNSNPTTSQKMDACETSQATTDNNNDPTDEPTMLLLSSRKRRPQLSIKDKLGILDFAKTSSIRASSKHFNVDRQNIREWMKQEQNLRESLNSAAKRKRRIGGGRKLSNANFDKTLADWVKELRENNVRVSRNMIVARAQQISGNYDNLKHFSASHGWLECFMKRHNFSLRRPPITVAQKVPESHGAIPNGLAILAQRREEKEGTGLLREVEEIDLGEEEVQSDVSIDANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTW9</accession>
    <name>A0A914HTW9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTW9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g373.t2">
        <property type="protein sequence ID" value="Gr19_v10_g373.t2"/>
        <property type="gene ID" value="Gr19_v10_g373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g373.t2"/>
        </source>
    </evidence>
    <sequence length="405" mass="44334" checksum="7B6313298814E26A" modified="2023-02-22" version="1">MKKLQPFDGGGIDLLLSRVSYQLTDLLRSVSLLTSCTSAFLLLVLVAFAFLCLAVGILLWNAYGALFKDEVVGRIGCKFDEFNKRQLDRCSDGHGQEVGSSPAPVDLVELSVVLVGSSISAPVDQLLQTATDLLGGLLSQLQTLLSAVQLILPIIVGIFALFCAFFLLLARANRQNCPAEVRKNWWRKYHRRTEANNANVSQVPCRWIKSLRTSTIALVELVDHVNRFLSVLTIFLPVFIVSLALFLIMIIALLALSIFLQFKRHINQSRGEKMEGNGASRMRRPEEGEAAYGIQWSRPHQEEAIPSPPSEMTSPTSPTGEGIPLPSVTLLEGKEGRRRFWPIQTANAFPSSNNERAAYPADHVGTTPVSPGLSPTSDSVFLPANVVFGRHGAHNAGQFSAWGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU29</accession>
    <name>A0A914HU29_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU29"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3989.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3989.t1"/>
        <property type="gene ID" value="Gr19_v10_g3989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3989.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="12160" checksum="B83813F1C663FC54" modified="2023-02-22" version="1">MSITKSTDRTPKLDKLNPIQLFRMLLSQSYEQAAKLKERLFQLDKAAKLKERLFQLDKHEQASKLKNRLFQLDKHEQASYEQAAKLKERLFQLDKVMNRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU92</accession>
    <name>A0A914HU92_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HU92"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4043.t3">
        <property type="protein sequence ID" value="Gr19_v10_g4043.t3"/>
        <property type="gene ID" value="Gr19_v10_g4043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4043.t3"/>
        </source>
    </evidence>
    <sequence length="233" mass="27633" checksum="4B5A59F5C61A9EAF" modified="2023-02-22" version="1">MSNLRLQKRLASSVLKCGKGKIWLDPNEVNEISNANSRQNIRRLVKDGLIIRKPGKVHSRYRARERLEARRKGRHMGFVLWMRRMRVLRHLLKRYRDAKKIDKHLYHELYLKAKGNAFKNKRNLMEYIFKKKTENQRSKQLAEQAEARRNKNKETRKRREERLIQKRKELLHKISESEKEKTPQPVAARPVEKEQPKPQPIAARPVDTEQPKPKEETAGKRQTVGSKKKKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVA1</accession>
    <name>A0A914HVA1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVA1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4495.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4495.t1"/>
        <property type="gene ID" value="Gr19_v10_g4495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4495.t1"/>
        </source>
    </evidence>
    <sequence length="520" mass="57416" checksum="612B5651DC5ED062" modified="2023-02-22" version="1">MNHPDAFYDDFGPLNLALLFRFCQFLHALVLHHGPGGSGQQAQQQTLHQRGSKESSKRRLTGRLLHVRRKGVQIQMVGLFAHFDADEYEHFERVENGDLNFIDGSTPNEAIVLRFLDVVDSAKELTEWSRKRKWRSAAKKMPKLNGVSNAEKGTKAKQINNRTGHQVETEQEMNPTMRIKRDLYGARGGKNYYSCRKNAKRHRISQHKIPLQEAQDGSIKRIKLTEAELAQKDCAMKAQQAETAAKAGGKDKTVHVALGYSCRKNAKRHRISQHKIPLQEAQDGSIKRIKLTEAELAQKDCAMKAQQAETAAKAGGKDKTEDYGRAQDGGGAFIDHHQQQQQEHQFRNVQPQQHQRQQQQQTMYSSAAAAADDHHHAHHRFQHGDSVAGAPSAAASFYQPSQPSDSETRPEAFNAGGDGVFDGIRKAPQGTAAAPKGTKKSHKASTNPPAHFCPHCGRGLSSDYSLKRNCQSCPKLLGKEGGAGGGGGKKKGFEKAIDELHQIICDPDSRMTESPLADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVF0</accession>
    <name>A0A914HVF0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVF0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5032.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5032.t1"/>
        <property type="gene ID" value="Gr19_v10_g5032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001967">
        <property type="entry name" value="Ras-responsive element-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="682"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="381"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="792"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="953"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1094"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1102"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5032.t1"/>
        </source>
    </evidence>
    <sequence length="1115" mass="127248" checksum="14526F19DAF9CEE0" modified="2023-02-22" version="1">MTLPSCSKDGTASLSPMSFNEPNACPMLERMCYQRVTGRFCDACIFVKERQFSAHRMVLAAHSPYFDSILRHNKIAKEKIVVNCQEPIVFERILNYMYSGSVTIDRVVVMELLKLANNLLMLRLKNYCADYLMRYIDVANCLAVRDLATRYNLPRLQKHANEFFDSNINGCLLENADVLGWEPAKLVQLLDDPQHMNNIRADVYLNLIVRWVGHNLSERECFFLELLSRCNLHQVLPSKLERMLDFNSFFVHSELSLHALLQIMHDQGIPMQRYELRYRNLVQKLMGVENRDEFRRRSCSVTGAMVGTENGGISFQSAVEGVNRCAGDEEADPEFIAEMGKFQQQSADIASSHQQSLHPRPCESESGMMRPTLKLKIQLAAPAPADTAHQQKTSSFSRQIQGKKRRMKLYRKSVASASRQGGLPPRRRGRPPKERSQRSLCDFAGIDEEPSSIFFEFPDEDGVPNVPAVVFDEEDEFDPQHIALVEEEGPEEGNIESSGKDDDPSGQPSQLVQCPYCSFQTRRGPLHLKRHDASVHSRNVLYVCNVCQFECRWNREFYQHMRQLHFPGPPYNCDSCTYDVDRLTVLLTHRLTHTDEKPFKCSECTFRTRNRANLVIHHRLHTGERPYQCEVCGKRFVLKRTLEHHSVAHSEERPFVCDQCDFSTKYQSHLISHRRIHSGELFRCEVPDCDYSSPKKSQLAAHLRTHMGVKSHKCRVCHRSFVEKSHLVRHERIHLEEKPFKCQNCEYTSSRRDKLKEHILKHHNQSQTNTRLLKRRYRRARQLQQLAAQGKLFPLSTADQPGTSSTVGEPSTNFFRPIPESELKQPRDDQPNKNNQTSQQEQFAPQQPPPPQQQRSAVAMAMYNLDALNVAGWSGVQQQMVGVAAGGAVGSGQINNSMMNRPLSVQPLMTNMEGGTFQQLSPSCFSLAADFPHAGDFFGEGAASQKVQRGGQIGEGVVGNQGQTHHHTATPDTELSSLSTPGPPPSHSLGNIYQQLQQQQLPTAGDEHHHSHHHHQQGHQQQQRMTNEGMMGTGVLFSSTMMIGDAVGGDPHHNQQQIQLQQMNLLQRPMSLPNYQQQQIQFGGNFEELQQQQFQHEQQQQLEHHREQQQHHFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWK2</accession>
    <name>A0A914HWK2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWK2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4690.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4690.t1"/>
        <property type="gene ID" value="Gr19_v10_g4690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="348"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4690.t1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62409" checksum="4821EFA6E0CE62DB" modified="2023-02-22" version="1">MPISTESINGGGDTTTDQECWPPNFANLDSSEELRLLRARIAQLERQQTINSPTSSDTFDLLAQNENDSCVRLREKCYNLWDLVRYKYSSILPIFLSFLKIKNAVDTLYKQNDEIGPNNDKSNVEKFDQLEEKIKQIDLELKGIKQLKGEQIVKMEEYQNNQQQAIIDAFTEKLKVSIDQFSLKHKENEKLLNAQQNLMEEMNLKQQQHQKETNDKIGWLNKDQEQCVSIDQFLLMQSDQKALLDRLEQKQTANAGQQKTDQKALCSTIDQLFNEREEQLNNFFVQFIEEQNKKLEERKETDRMFQKQMDELGNSSKKELEKEMNQLKGELITKMEEYQQQQQLNIVDLQKAVAVLNNAIGIGLPLQNRWDAAACHHELALIEPDRLTVQVTGKDWGYHSVFAERPIPKRNFGIFYYEVKILTQEGFGHIGLATKQMPLDKCVGCYNGTYSYGSSGKFWGHAVDGCSYCNGRPYTEGKPRGVGDVIGCGVNLASRQIIYTKNGQPLDTANLFVDSDTNLFPCVSLFLSGTKIEANFGPDFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX30</accession>
    <name>A0A914HX30_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX30"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4937.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4937.t1"/>
        <property type="gene ID" value="Gr19_v10_g4937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4937.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="14859" checksum="E9F4C7265B91EBE4" modified="2023-02-22" version="1">MQNPTSGRPLTTSDFFPNNGGLDGWGEGVRQPSHFPLLFPSLRRQQSRRWEAIVECGVAATALPQGEGMAGGDKESIGRSASPLLSYKPNQDQASHSPHPTLPLSPPLPPIAAAVPCPSPHLISTHCSPPTNSSQYLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY56</accession>
    <name>A0A914HY56_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY56"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5555.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5555.t1"/>
        <property type="gene ID" value="Gr19_v10_g5555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037962388" evidence="1">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5555.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19352" checksum="AC29335502A335E7" modified="2023-02-22" version="1">MRFCLIFAVVVLFLIVRAWGGCIPSKQTSQMQPPPEPKADKAIRPISEPKFHFFDSERFRQKLISTFHGPGSRCRLEVDDHVFPQGAHLILYFSLESSPASAWLVFTLRLLQPFSCTMNSFGKNEKYQQQQQQQQQQQQQLVFPDRDPLELATGPSVEWYECRKSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY91</accession>
    <name>A0A914HY91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5588.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5588.t1"/>
        <property type="gene ID" value="Gr19_v10_g5588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5588.t1"/>
        </source>
    </evidence>
    <sequence length="489" mass="56774" checksum="56CE9CB741CD10F0" modified="2023-02-22" version="1">MRLLDNYRRAMAKSSSDTERLSGRLAADVSVWMNHLSEQFSQRKPPPSPSVSVPSASAPAPTSPLSPFSELVNYVWLSFRIIYDICDPTIVMNSNYDFNYKRLSLFLNNYLYEFDNFIQNERKKKRFTDVLKNWKANEHSVLCISDLGWLNEDDNKSAAPLELTQQIHFEVLQKYMDDKEIGKDFREIFLGFPYFIQIGAIILPVSVSKTVGENNKNHEEKYRRKNLLQFLKIENIKKLFELHKITYNESDFMGNESEEEAENVKKMEENPSESDKNAVENVKKLDDVSSVNAAKSQQIMGKNDQSFENIQNIEENLSDSKERPFNIVLVQKNAVNFVEKYNNSIVFNCVAEDKISYDKFCNFVEEQIRSEFTALMEKIGIKNSKEVAFLNTESYKETCGVAKELVQEKFSINFCKLWLVGIESSPMHNNEKLNEYLKDFNSAIKSNYLLKFNHSSADENDKISESQKLRADVHSTVQKKWFLMQIMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZN9</accession>
    <name>A0A914HZN9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZN9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6147.t3">
        <property type="protein sequence ID" value="Gr19_v10_g6147.t3"/>
        <property type="gene ID" value="Gr19_v10_g6147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="858"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="943"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="795"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6147.t3"/>
        </source>
    </evidence>
    <sequence length="1151" mass="125280" checksum="B28101D1EB04D748" modified="2023-02-22" version="1">MHKMFFYSELMMMHSSQDPSNSYPQHCNNNNAHQSPEGTTALPPEAVVAQQMISANVALLQNGGVKNEEVKKESTGEEESDDEEMEDEEVEDDDEEEEEEEEEESASGEEERQRHAAAGPTEGPKMHMAEPGAVAGAGTAPAGGELQTIRANLQILNHQMALLMRTLNVASCTCAECQDAQRVQHCVALPAANGNSSQLQQLHAAGLNMGGTSGGISSFAPGTPHNLQQQHQNLFSASSGGGTDVGSAGDSAPRGRRSKYCTPEEKKAVASYVQCHGATAAARKFNIPPAVAAYYHRKEFKKQGVAARRSSVSVHHAQQGQQLQAGDGTKVELGDGQQGDESGMEQIGQLWQNNYGGGYLRGRGRGRPKLIGDELDAELVEYIVQLKQTNPRAHITAAQALVIARKYIAEKAPGLLEENGGQVKLKITWAMKLVTRVQEREREIQLGLPAGSLQNLPRSAFSNAAVGGDQQQSSASSALVNELLGQNLMGNQQIDVNALLAAAAAENPQQIDLNDAAVLNLLGMAAGGSDLFSSNGGGGGTGMSHEHPGCTSTGVGGQSTSSAAAAALQQQQNQRYKQELAESDEAIRQLLSSLQGGGAEHVGGAVQHQHQQRARDGAAGAELSVADLSGHVLKQNAMRLNNNKNCLPLLIVFLTLHIILICSKEEKKDSTRPRGVSPQLAPLYQERAEFECLDGKKRIPFEQVNDDYCDCADGSDEPGTSACKNGQFYCANFGFQPQTLPTGRVNDFICDCCDGSDEWDSGIDCPNLCDALGSKAREQAKQSAEVQAAGYAKRRELAKEGAKMLEEKKLEAEKTKNELEELTELKKGAEEAKKEVEELEKEAKDSQEKEWEEAKKELVRLQAEEMFGKMEKDGDGKISSDELKRFAGFADGGDSSERAKELLKDLFKEDSEGGGDEQIDNTLLNFDAFLEKFEMAKEFVEEITEEEAKSAATTTAPEADEDKRSAEEEDDKSEESDDETRKKYDQQTRQLIEKAEEARKEYNEIADKVSDLERTVRDSESFLNVEFGADNAWAPLKGKCAELTTAQYVYILCMFDRTVQKERNGHAEISLGHWGKWAGPEDGNKFKAQLYEHGQTCWNGPERSTFVQFECGEELQLVDASEPSKCEYHFLAKSPTACADPEELKGEHAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0A7</accession>
    <name>A0A914I0A7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0A7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6304.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6304.t1"/>
        <property type="gene ID" value="Gr19_v10_g6304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037402837" evidence="1">
        <location>
            <begin position="22"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6304.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="46235" checksum="F61453CA8A891FC7" modified="2023-02-22" version="1">MWITASLSFPLLFIFIVPAGAVVDVSLSMSQMSLFLIKMDNFLASKCELNKYAFMGHEQEKEWKTETKKLINELKVVELRSYFGQPNVSEIPMKIGQKPSTICADIFMDLLLKKMLEKLPQEKNVLNVNELSKLTQKQNLLMLLELFYISSTFGNVFFANTKYYEELEWKFNKAEEIIKEILNKEYIKGKTSWFDIHQHFSVQNAWNEPEENILAWKLEIKLEILKLAQIIKIIGQFINKNCGKNLWNLLEESDQLTKCSILLDFAELEQNFAKELANSFDNSLNLVNLVGQILTSETASSNSKASTKWHCAFKVKSLTQILDDEGRLSVLRGLLQFGRLFMENFNGIFVTEMRKPTEEARKMEWKNILIRVTLNEHKLDEMKMLNKLAIDAGLIERMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I106</accession>
    <name>A0A914I106_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I106"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g63.t2">
        <property type="protein sequence ID" value="Gr19_v10_g63.t2"/>
        <property type="gene ID" value="Gr19_v10_g63"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF144">
        <property type="entry name" value="BPI1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036903426" evidence="4">
        <location>
            <begin position="20"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="5">
        <location>
            <begin position="172"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="6">
        <location>
            <begin position="492"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g63.t2"/>
        </source>
    </evidence>
    <sequence length="768" mass="82233" checksum="CD454A3DF6BA01F9" modified="2023-02-22" version="1">MWKPSLIILIFSAIICASSVKLPRAISGPGSYQTKPKGYANRQNVKPNAGPVPKSNIVQPSRPVSNTVPTSNSDLGIDSSSNGTVPTSNSDLGVESVDQVDASDALSSNISIAASNVSSSVSDDNEQQQQQLLQAVNCDGPPPPCNLAGRKDFNPALAASANDSTQPGIKARLNPAAFRYMSRELVGILNYQIKRAKLSSISQCLPQADGCLRIEHLHVNNYKCSKDVSFKPAQPNRLVMDVRNIDVSVNGDLGGQITIMHALALFGQVQVTAQKVKVIVGVVVENSAITGSPKLRVVSCTGRVGNVQTSIQSGGLLGDIANQQLKHKINKIVQRQVTSQLCKRVPQMVEEQVNPQISGVVPKKIAFKSIAQVALNSSCLSALTESGGTTTTKTTTPLTTTTESSSSNGTTLSASETATTKAPAKKAPSPISLIMQLMDMKKLDNLFLNSQLLGSSATSNDYTIKLRGDFSVCGWGCTPFSPFPAQIPACIGKNCKMADILLSDYTINTMLYHMHRVGFFVVKIGPDTPAVGRLMRLTCESGDEDDVSLDDHGVEDENGTLIVKRSPISRRIKRQDEDEDLVQTLIDTGICIRSLLPAAADEYPDEKVDLIMRTMRAPSATIYENGTIILEQIAKLEFFGHTNKKKLGTFKSTSTAQINVNSEGEIIKANLTLPSLTLTDIGTDVKSGMTQEGLDTLTSLMKEKVPESANKKLAKGCKLDMPPGVGGIPIRVLNPEVHFVSRAVHIKSNFELYSADGSSPLGASEPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1Q7</accession>
    <name>A0A914I1Q7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1Q7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6689.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6689.t1"/>
        <property type="gene ID" value="Gr19_v10_g6689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6689.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13214" checksum="F50F8520627F5A33" modified="2023-02-22" version="1">MKNATALQQADAVALERPFDVHRSFAATLLKLEEYQKEQRQNQTEICVQIGELKKLAARANVVASGEEHWKLLTELETLRTQMAQVKGLLKMQEQREAQMLYKHGTVFRYLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I206</accession>
    <name>A0A914I206_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I206"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5882.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5882.t1"/>
        <property type="gene ID" value="Gr19_v10_g5882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000067">
        <property type="entry name" value="Glycine receptor subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038169854" description="Gamma-aminobutyric acid receptor subunit beta" evidence="20">
        <location>
            <begin position="18"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="22">
        <location>
            <begin position="106"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="23">
        <location>
            <begin position="333"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5882.t1"/>
        </source>
    </evidence>
    <sequence length="650" mass="73114" checksum="C97C41ACE8A1AC45" modified="2023-02-22" version="1">MMLLLLLLITNQRPIWQVTPRQILSECCGATTAEAADEFVIVHYSFCFYSQLALSASNLQVENEQPNGAVGEQQQPMVQWEHEPTAYQHHQQPHEEHNGFNTTYISQILNRLTDSRKYDKRLRPRYGEGAVDVGITIHVTSISAVSEVDMDITLDFYLRQTWYDPRLAFQQLDPELARRIKKLTVGVDYLERLWKPDTFFPNEKTAVFHLATTHNSFLRIEPDGRIYTSQRLTVKAMCQMELQLFPMDSQTCKLGLESYGYDVADIDYYWGERRSDGRRPEDAVAFDVFFLPQFRRTGYRVTGTHITTASGTYARLYFEVIVSRNIGFYLMNIVIPSMLIVAISWVSFWLSREASPARVGLGVTTVLTMTTLITTTNNTMPKVSYIKGLDVFLNFCFIMVFAALVEYAIVSYWNKRQCRRRDRRERTRSAPAMRVAGAHRGDSAMPSTGAEYPMFMSYPTTPAGGLAVPSPNTQSYVYRAPGLLVPAATSTTTAPSGNVLSGASGGTQMPAGSGTTTAISIPPECDCRLGNIPLVQYAATDFQQQQNSAVPYMMAATGAKLGRRHRRRPYSYYSGMGGGGASPFLASSTGGGHRSWLCRTLHCRSPSKIDRLSRSCFPLLFIIFNLVYWSAMTIMSQRELEKVDFVPFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2E9</accession>
    <name>A0A914I2E9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2E9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6244.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6244.t1"/>
        <property type="gene ID" value="Gr19_v10_g6244"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6245.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6245.t1"/>
        <property type="gene ID" value="Gr19_v10_g6245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275817" evidence="1">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6244.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6245.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8296" checksum="B64737FF4FEED8E8" modified="2023-02-22" version="1">MATTTIKIVSFVLLVLCIGMAIEQSQAYWWGYGYGSAYGPAYGYAYPYGWYGKRQAGFGPSAAAGGADANVGTLAKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I347</accession>
    <name>A0A914I347_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I347"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6171.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6171.t2"/>
        <property type="gene ID" value="Gr19_v10_g6171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6171.t2"/>
        </source>
    </evidence>
    <sequence length="276" mass="30965" checksum="BE3D610B2E74A514" modified="2023-02-22" version="1">MFRHLFEWTCDIYLHGNATFSTVGNVRRVNLGHWQFNGTSNHQNDRNGTGHFDLGNSPASPALNYVGLLFVIIGGILFALVPPKTQQQNESAEERVEDRESLLDNDQLEETERHEGRHGDGQSVAQIRQGQTTLNQRIIAIVLSVFAGICYGSIFTPVVYMQDNPEKFHPPPPKGGIYYVFPHFSGVYLTSTAVLIIYIAYKKNRPYIDNRLIFPSFLAGVLWAFGTLAWFWANDILSQAITFPITEVANEHLKLYIAAMFLSIIGVTMVGLSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I478</accession>
    <name>A0A914I478_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I478"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g646.t3">
        <property type="protein sequence ID" value="Gr19_v10_g646.t3"/>
        <property type="gene ID" value="Gr19_v10_g646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g646.t3"/>
        </source>
    </evidence>
    <sequence length="252" mass="28473" checksum="184AAE0C300D57C3" modified="2023-02-22" version="1">MQPNKLKFIQRLLIHTAQDDAIYDVAELKSVSLFRTTEQRVIMSAPLIMPIIYGKKHCFCGIPVQTAARVIAIVNIAFCALGIVLAIYAYGPSTMMTALKWRNPKLYLPYLAVKGFFTLLGCLFAVFTLCLTIYVLITEGISKRGIMGIAACAVNCVFVPFCIWLYRLVWLAYKEAAGLFIAFSLQTILVKADEPAVLNTNRSTSFAQWNEFELEMGISMEVNMVKMKFADLLIASAPSNLSEWKKYWQRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I592</accession>
    <name>A0A914I592_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Papilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the papilin family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7014.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7014.t1"/>
        <property type="gene ID" value="Gr19_v10_g7014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000017">
        <property type="entry name" value="papilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1152"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1213"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1333"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1442"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1536"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1593"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1744"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1803"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1886"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="1974"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="21">
        <location>
            <begin position="2109"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1277"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1392"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1644"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1803"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1279"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1406"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="143"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7014.t1"/>
        </source>
    </evidence>
    <sequence length="2149" mass="235355" checksum="46723BEED9311D0B" modified="2023-02-22" version="1">MAFERCKHWQYKERPHKVPSFCDNIALEVEMTSFSAAHWHFVFLLPLLLLSFVPLIALASASSEAADDGAVPLPLHPSSPPHRQPAQQNRAKRQAYQVYLGNEVSVSVDRGQVVDEGPWGAWTVERQCSRTCGGGVYVERRICGGGGHCAGPSIRYISCNLEPCPADAIDFRAEQCAAHNDDPLDGKYHKWVPYAGKNKCELTCRPESGSFYYNWAEKVIDGTKCDAYGQEICVDGICLPVGCDGKLGSEAKLDKCGVCQGDGSQCKTVEGLFDERALPSGYHDIIALPAGATAIHVEERRPSSHVFAIKNATGFFFLNGNFQIQVLDKDIVAGGAPFKYGKGDSGTERLTAQGPLQEPIIISLLLQHTGAKQIAVKYEYSVPLEKDVKFLYKPGEWSQCSVTCGRGVRTRALYCIDTATQARVDDASCEEHNATKPEFEKKCVTVDCEPEWFVGKWEPCSTTCGDRGVQFRVLYCHRVFADGRRITVSDANCTEERQLPRPDMSQQCARWSCPEWQAGPWSACSSQCGDAKQFRSVTCRSAKDGEEGKLLPAEACTGSKPSTERDCNLGPCEGLRFHTADWELCQKCNDTEETRAVNCVDKNGREYPLEKCLDGKKVTKIPEDTRPCASQAPCIYEWHTSQWSKCSTECGHGHTQRKVFCAINELGQTKRVDEALCGQSADEKPVARDECVNEEKCTGTFFTGPWTNCSAKCGGGTQTRTVVCLNYDRKPVPEWCDEKEKPPEEQECGMDSCPKCADSEHGCCPDEETFASGPFLEGCSNCSVSDFGCCGGDNMTAKTDEAGTNCKEFTEPLGGEEGSGEEPVDAEASSPTDGKALCEIVNQDTMEKFQIPCADTVLAAANETVELLKMAEDEAIGGTNATDGEKHCSKSEFGCCPDWSTPAEGPNYAGCPKFVLGNCNGTKFGCCPDEVTMARGLDFEGCGEPTCAASLFGCCKDRRTIAFGPHYAGCDRSSFPCELSPYGCCEDGETAALGNNGTGCGASCLLTKFGCCPDGKTHAKGTHNEGCGCEYAQYGCCPDGRKAATGPGFYGCPEGCAQSKFGCCPDGKTIARGANKEGCPCQYTRWGCCQDGETTALGPLNEGCDDCRYAKYGCCLDGVSKAIGPDYAGCPTTTAAPFIIGGTVSPTQIVSCSLPQDQGQVCHPGYQLVWFYDIAEGRCSQFWYGGCAGNNNRFANREQCEQSCIEPPHLGRCYLPKVEGPQRCTQLAARYWYNYVTKQCQAFWWRGCLGNANNFGSWEECQKFCELADATQVQVVMPQPQPQQPPQPPQQQPPPVAPPPVQPQAIQAPLQPAPQTVAILPPGLEEAGELDSCRLNVDSGNCQNYMDQWFFDPYSGACFLFIYSGCGGNRNRFGTEAECIRQCGHLRKPKPGFLGQKQLPPPTPAPTAVAVPPQQQQQQQHKPKVEKMTTGRKALTKSRDVCNLRPDIGKCEGHFESWYYEVASGQCEKFEYSGCGGNANRFNTPDECQAVCLRRNDFPSPQRPGGSVSAPAPLGPGNLEQSLPIIGDKQHLAHICDVPKDSGACKTFITKWFYNMRDGTCVRFHYGGCDGNANRFDTEEQCKNTCGNYKDTCHLPKVVGPCEGHTPRFFFDLHNRQCLPFEYGGCLGNNNNFRTLEECQARCRPSTTTTNPSPVRLTRANPMPVTTAELLEDDDDNDNRRNDQTRPSQQPGGDQNDHFDQSAVNGGIVNEEEEQDEQQQQHMDEDMVVVPREHLLYGQLPELCLLPEQRGTCFGEQLRYRYDTSAGDCVGFLFSGCAANANNFASYEACARACGPWKAEPVCEQSPDEGREQCNNGRRRRRRRQNDMAGANVPKWYFNAALGKCALFFWSGCGGNGNRFQSKSECENLCQREILARTHRRTGRACAQTMDAGPCEDLVTMWYFDAVQEQCRRFTFGGCRGNANRFVARADCESQCVAAVANTSGDSHLNANDNFGVPQHLSRQSAHRHQHRRPRLFAFPVGTLLVGTSTLTLKCVADGTATPKAFGGNEANGEEEEEDNNFTWYKDNQQMLTTQADDATEQQQQEQRVKFFESVTTHAGGGEAAVVGELRFRSVRLMDGGAYSCAFGDASNALISEPVIVRVTEADPSLTLCPGDNGPAHICRTVARTGLCSTLRYGRYCCRTCAIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I637</accession>
    <name>A0A914I637_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I637"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7244.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7244.t1"/>
        <property type="gene ID" value="Gr19_v10_g7244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7244.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8811" checksum="8E7257E98AC739A3" modified="2023-02-22" version="1">MSTAKEASAQATRGRMADDDLDEEGERGERSPEGDDNGTPRHTLSIHWLYAMFRVFRAGRQKGCSRVSASSRQRSSGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I642</accession>
    <name>A0A914I642_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I642"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6969.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6969.t1"/>
        <property type="gene ID" value="Gr19_v10_g6969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6969.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7224" checksum="BD41E9400E89F8D4" modified="2023-02-22" version="1">MDNKPLKKWIKFLHSLSLHKRPAMASVHPANNAKTDGYTTATAEDEHHRQILALNSSENGGSDGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7S4</accession>
    <name>A0A914I7S4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7S4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8282.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8282.t1"/>
        <property type="gene ID" value="Gr19_v10_g8282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8282.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9282" checksum="45A4258165991B72" modified="2023-02-22" version="1">MAVDVNSALSKAYDELRTIDMDLSMVSGVSERFNRKRSAPINDSVSSSFDRRVQDGGRKIIIGPESSDRYAKRGRYADEGPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9C8</accession>
    <name>A0A914I9C8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9C8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8101.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8101.t1"/>
        <property type="gene ID" value="Gr19_v10_g8101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8101.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22683" checksum="F5B2B3835C41FDE6" modified="2023-02-22" version="1">MDALKRNEVQVFVAVDKFADLEEQKQSNANNRRMTNWRTNCSTMREIVCRADCQPPNSTDYMRMKIAQIQCVTQPKKMVKQMECAVVKFKPVNAHQEHQALVKPDAKRELGKDGLNIVIPQSNTLSPRELLGWTAPVPPKDVTAIDMKQYKEELKDMKQYKEELKDMKQYKEELKDMKQYKEELKDMKNCRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9P4</accession>
    <name>A0A914I9P4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9P4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7903.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7903.t1"/>
        <property type="gene ID" value="Gr19_v10_g7903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7903.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23894" checksum="7629EB9B07262A41" modified="2023-02-22" version="1">MPCHKSFIEINFRKDKRARGARLCCPEAIAQVSPSQNWIEAEGPGTDIIISARLRYSRGPVKFELTYETDGGTILPSDLCPDPRGLFSQERNPGRSVACVDNMDKPTKEIPCSQRQTFYSCLTPNHYITVNGHQTNKTRILLECFKREDNPTSYWGYWENKNQDPIHIDDMQCVKYIKPKLFKRAEVEEAFENANGTIGYMVFKYDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Z3</accession>
    <name>A0A914I9Z3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9Z3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g866.t1">
        <property type="protein sequence ID" value="Gr19_v10_g866.t1"/>
        <property type="gene ID" value="Gr19_v10_g866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g866.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9285" checksum="863AA4C3EF65DA28" modified="2023-02-22" version="1">MVEIFGSGQSADNFLDKVSKLLLGWIKFGSVRQSVDTFWTTCLACVALPAVVRALPTYSTCASEGAKRSERSERSVATERVHGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICH4</accession>
    <name>A0A914ICH4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICH4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9564.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9564.t1"/>
        <property type="gene ID" value="Gr19_v10_g9564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9564.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39267" checksum="DA6783EA57D1F729" modified="2023-02-22" version="1">MNGLTFGALLNVVTEDATDQIVLNLKQFTPLSSILVKTLESLMGTIPERRNSINYQIIPATYIPLVTMVYNKRLDVKQILQEIEKNLEYYHDMTITLVFANFLNAVDKHHFKQAMPTEQIKFGEEKKSEFLLQSIYLFVKKITQKCLQLFDTDQNENLWDTSSKNFISHVKPVSESKLRVVYSQFCIAQSEGFKPVFGEWRTNWAENQPMIGFDHFLYEKIRIEIPTEIARETITDVKNVPIVLITRRHRGFSFRKKKKFFNVIIDGTEIVYTDAGIYMTKVDYFWPKEKYKKHIIFCADDIKKLAAYTPNYNKIVRSTRLTCVTGKSNHVLNLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICL3</accession>
    <name>A0A914ICL3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914ICL3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9371.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9371.t1"/>
        <property type="gene ID" value="Gr19_v10_g9371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="62"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9371.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45576" checksum="8B0232A29D64098A" modified="2023-02-22" version="1">MESTKFAPHNAKRLKTFGYISLATCAFVALILIANNKNALVGDQFTQMISLSAKEKNAKTMPPILVWNAEYYGDAMLRMLEGFVAGYPSLSDKVKCSHSCDYTDDRRIETNASAIIFFLHEKCPIDVWPQHRRADQTYVMFTAESPVNTLPYYNRSIMTDTWFNATVTYRTDSTVVMPYDRLIRITPDTPEEDIWTDLEVLNKVRNKSALAFQVVSNCNASSGRELLVKKLSEFIPIDVSGGCTQRACDQNCYWQKMDSHFFYLAFENSVCTQYVTEKFWRSLRALTVPVVLRRSVLAGVEVPQNAFIAADDFGSVKELADHLKALQNDTKRYLQHFEWTKRYRKSHFAILNSPLCTLCQFAHRQFEQDLTNNVNLDNHWTTKDCKTNFVQNFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDE5</accession>
    <name>A0A914IDE5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDE5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8873.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8873.t1"/>
        <property type="gene ID" value="Gr19_v10_g8873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8873.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="10058" checksum="95CCC87BD01213A6" modified="2023-02-22" version="1">MELLWKVEKRLTFKLKTDGHRQQNRQLLDFFDILPSVVQLSIRQRQMVFDLSAYRLGQIDQLAPRAKVCKCFHQQKEQQQTAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDG9</accession>
    <name>A0A914IDG9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDG9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9597.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9597.t1"/>
        <property type="gene ID" value="Gr19_v10_g9597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9597.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40509" checksum="9F30BD8D3B8472EC" modified="2023-02-22" version="1">MSDNPKKVEKQLDEIFVCDDVLFDVFKFCDPFVLGLKVALISDRFDFLVDAHFKSKEWSLGELQILRATGKKSAEIVKLIECYEVERRLPIPQEPLPVKVIGFQSLRISYVDRSVINFLQSIRRLFESKETNLFIGTFINQTSRWEIIWHQIWPLIIRNIYGFNLLYSFELDHLRQFSPTILRDCPKLRAIDSGLLFPEFPADDRAGASSAKALAKWLHTPRGDGHPKVLQCDFSSERLERLKVGFFNSTDPVNFIICFRILSSADIVPFELKNNLTEERLEFRHFGRCFWLLIRCPIERDEDEWANWEKEAVGWEWRHQWKHIIIDFDDRAIGGGMFDANEGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDH0</accession>
    <name>A0A914IDH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g984.t1">
        <property type="protein sequence ID" value="Gr19_v10_g984.t1"/>
        <property type="gene ID" value="Gr19_v10_g984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g984.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10420" checksum="3AD3F4D6CB198C06" modified="2023-02-22" version="1">MEQLRARETQWNSSGPEKPNGTAPGQRNPMEQLRAREAQWNSSGPEKPNGTAPGQRNPIEQLRAREAQWNSSGPEKPNGTAPGQRSPIGAATARAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDP2</accession>
    <name>A0A914IDP2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDP2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8940.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8940.t1"/>
        <property type="gene ID" value="Gr19_v10_g8940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="716"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8940.t1"/>
        </source>
    </evidence>
    <sequence length="895" mass="97080" checksum="EE0EEF74CE1B958B" modified="2023-02-22" version="1">MVPAQKPVPALISISSRGISHSFILWLHPHQPPNVRPPPTPRLDSQIGGPGRSNAVNFPSQQQMPSVSSHRYSDGQNANGERRRRRPSPPSPSDDDSNSSTTVGHTECRQLQACNVLLSVLGAIGLGLAGTQFQPRIGIDNYRQIDLRLSTSLLYTLTGTVGFFCVGRSSGSVLLKTLYTLTVLFALSTAIFYAFTTYKVIDLHRQLVRFEQLGGAFTGAFGVARTSADFVPKTIISSAMIGLSLFTGIVGFLALALLDRLSVVERPWYAAQREDQLRSKFNKTLLACTAMIKMLTGIASLSLAAFLEYENAQLALRQEYYRIILDQFSVVLALGSAVADFYACYNKLHCSLNLKASIALSVVSAVWSLKSVDNNAFPFYKMDINQYRVAVHTSETTFVTISPPQYAIVIIHGILIGLLALLALLSACTAILAANALRECVAKRDEQAELGMQNRFLALLHSFWALCLLVLALLGLAELPWNGDFIGADLLWLAVLVFGTGLLGSANKRISTLVKFVTNCLTLSVCTEKCVASINLIFQSATHPDYLNPAVFDSRSRVGQIVLHSAQCVVLAGASLTALCGAIVYGRTIRAREAPRRQPFSMGLNCCCSLSALFYALVLLTSEVFFEIDKWRWSEVTLEQTGHQRLGNGLLGLTVFIVQVFCGTCPQMIASATILQIVLSSLAFFTLNSAITNVYYLQVLLNSRLAIGLSINQRTLITLGICFAAASALACALQVICGIVVIFCSLHLLHHWRGDGRRQIFSVLGGDGPDTSYLSYSGPSGVDDHWGDGSAGGGGGTLLGGSVFQSPSLHQIAIQPIEEQTLYWSAEDNPYIYKSTRRVYGQPALLMTPDTRTGDESGYGATPSPNNLWHQHAAAVANGAGRRRDRRASSFPNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDY8</accession>
    <name>A0A914IDY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9964.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9964.t1"/>
        <property type="gene ID" value="Gr19_v10_g9964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037815132" evidence="1">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9964.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15334" checksum="4E151F98154E2A1E" modified="2023-02-22" version="1">MELVLVGVDAFLLVVTAPGRSIYTDDRVYSVLLNDRWNKDRGMKTDRWGKGGEQDEAMIVLDPQMQRMCFPRVEMETEDPGTPTLGFALRSSYSTVLARLRIWNEQLVHHSRWMTWEVGEEHPGVIPVQRGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IED2</accession>
    <name>A0A914IED2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IED2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9843.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9843.t1"/>
        <property type="gene ID" value="Gr19_v10_g9843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="159"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9843.t1"/>
        </source>
    </evidence>
    <sequence length="492" mass="56359" checksum="8EA8C07FEE699807" modified="2023-02-22" version="1">MINRFIRNFLNGQHIIHKFRHVQTVRLTFLHQCIKNECPAPVLSWGCAARMASSSSSSSKRPSHRSKLLSDFHKNRTANLQLTNLGKHVVELAQDSQGFIQQKLECANPTEKAQLVDALRGHVVTLAMHKSGNHVIRKALKTLIIEITAQVLLLSLHKCGCWVIQCVLEHCTEQQKRHVLEQLHGNVSTLVTDKYGSFVIRHVIEHGLPEDREPIVRSLQEDVLNLVTDKYGTFVIQHMLEHGLLEDRERIVRSLHENITSMSLHKYGSRVIERMLEHCTEQQKRPVLEQLLDNVLSLVTDQYGNYVIEHVIEHGLPEDRERIVRSLHENVISLSLHKYGNLVIQRLLEHCTEQQKRPVLEQLLDNVPTLVSDQCGSFVIEHVIEHGRPEDRERIMRSLQGDIMKNTHLHSFCSIIEKCLIFGTTEQKNALIDQVCADDGTGKTPLLQMMQRPFGKDVVQKMLNVADSARHQKMMFVINTAPIKNTKKRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEF6</accession>
    <name>A0A914IEF6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M13 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IEF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g914.t1">
        <property type="protein sequence ID" value="Gr19_v10_g914.t1"/>
        <property type="gene ID" value="Gr19_v10_g914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="483"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g914.t1"/>
        </source>
    </evidence>
    <sequence length="617" mass="67413" checksum="447665089BD1DC1C" modified="2023-02-22" version="1">MALYGVQYSTLSGEELEHWANEQLPTVTSVMHSSSFTLPLRSNNSGSIMNLHQTLGSEYFGTRRSAAGVVGAEGGGGRQMSVSSAGGTISGASTISAGSGSGMITIGRKGIFFARETHWTTFVHINKLLNKRQSYQQEALWEIIVPIAGRVVKMSFNGRHCLCYSTDAGAKDGGPLKLFNGATARHAICASGLGEFALSALHGYEHCCDQCRPGTFDLRKCDLPGCSECFCFRVTDRCRSSNWPIQMLRIPDEAWSLKIGTKSSTNGTNGVEHGRIVHAPESASGSVLPMDITFEADLQPGLNCTRMYGLDLSYAISSFHNPDRPKTFSRPVVRLVSAITPPKNLCQVFFLLLLIGQVDAAILGASFTTTLIIGLFAGGAIGFAAVWAHNRFFRRRPPQPPIGNNNNNGNNNNGAGGGGGAGGGGGEGANNLAAYHQRRAEQNIQLQEARLAAEAFEAQLPPLPVPDNDALAIAISSSKKIPEAEFGRDVAEIIRFEKEFAQILIQDEERRNFSKMYNIRRLSGIERDIFPNLNWTAYFGWLMPDVMRDYVASDPEVVLAEPAFFVRLTNLLRKTDKRIIANYVLWRYASAWSFQMDERYNDIQQIEDAFSCPVGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEL4</accession>
    <name>A0A914IEL4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9908.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9908.t1"/>
        <property type="gene ID" value="Gr19_v10_g9908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037321099" evidence="2">
        <location>
            <begin position="31"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9908.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29681" checksum="DE8B7558E02BAB8E" modified="2023-02-22" version="1">MFNYSRSFLLIFPLALVVILFALSSNEVQGQCYFMNCSTGFKVRTEWGCLSDEQTGKKCRLANEEAAYFENDGFKCRCRIGENGILMSNEKDTGFPIPVTTTTLVPPSTEKTTTVTTTTTTTTTVRTTTTTTVPKHVCKQKMESAENSTVFGDQCPAEENFCYFLNCTSGTSPNKTLIEWGCMQNLTSEICVQKLGKLGFSLDKDSCYCHVGRENQNITFLQKKMTLSDFQPAFSFAHRNISHFKAVVIAILLVSFASAIAHAMLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF03</accession>
    <name>A0A914IF03_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IF03"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9302.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9302.t1"/>
        <property type="gene ID" value="Gr19_v10_g9302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9302.t1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42447" checksum="F125BCB48159BB32" modified="2023-02-22" version="1">MQIYSKILLQTCITDLLLLIMTLLFQNYTFATKSGEQKTILDGLITINGAENRVWALLAVVCQIWLVGFSVVGYLSQFIFRYLVLNWNKKVSSCNYSIIFLINLLLPLAYCVHLFLCLYPSDGHEFLDDKSAADFIGVNLSEKIILVGYSNNKLNLTIGSCYLIIVCTITYAIMFILALLMHNNLKKLSKTITSKDLTAKMIEMNKQLSRNLLFIQASMPLMVCFGKMEIPSTSMKLSESENEDETGEDDVFEDQIFTKLDKSEPAHSLMRYFQFICLSCDAISLTEKPGFSELFEEACPSYSLKSRTFFTSLLEKKYEEKLALVKGRINSANYLSFTTDLWENRKKKKCFLSLTAHFIDNSFERQWNVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFT5</accession>
    <name>A0A914IFT5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFT5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9505.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9505.t1"/>
        <property type="gene ID" value="Gr19_v10_g9505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9505.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9789" checksum="C3A7774BB17121D9" modified="2023-02-22" version="1">MLCQMLTKTLQDKKCCGSSPTALNSQASLDLSFLYKCFPCTSCSIRRSMRSCCSTDCQESLRKFVTCECARTTVYGNTQNLDLICCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IHB5</accession>
    <name>A0A914IHB5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IHB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9904.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9904.t1"/>
        <property type="gene ID" value="Gr19_v10_g9904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9904.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10066" checksum="54E0E033B00182B7" modified="2023-02-22" version="1">MTSKKVPFAEEQNEQNFNELTGKKHALDLDTQFPRKQIENPERSKTKPKKPRKRNEFGFNISSNHSIMSSAEKDRTTFCLPLGCPLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GP86</accession>
    <name>A0A914GP86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-coenzyme A synthetase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GP86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10077.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10077.t1"/>
        <property type="gene ID" value="Gr19_v10_g10077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10077.t1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41479" checksum="5B305BAC40C92483" modified="2023-02-22" version="1">MLKAKHHTVHFGNCLISCFAARPRRPSAGGNVGLRTHWCNALVVDLTADSLAQRIVHAHARLLVTADGCGRGNKPIQQVKYIDDPDKFWRCVAEQLHFEQFSERGLELNFDHRKGDVFVRFMADARTNIAYNWRPTYRWEATRRATSTSAPKHAQPLPARLRPLVKLTPEATHRPSLLALLQFGQLLHRISTCILRWRVQVPRRRAERRFGMHCRVGERKRRSSASNPGAPCQYLSTVLGRRARGILSSIDLRVRVRHASAAGRAHLHLLSPELHETRRNLDSRNWPMSPSGPARSLSRCRCPNNQVFSGTRCMPPTCPWSFIRNQFGVCQPGCRANQIEYQGQCIDIVGPGQPCVMNRQCAGGSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPU4</accession>
    <name>A0A914GPU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPPDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10228.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10228.t1"/>
        <property type="gene ID" value="Gr19_v10_g10228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10228.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16979" checksum="9C3A1F9CBEBC0F7D" modified="2023-02-22" version="1">MANFDGVGMANFNRVGVAAVARSEFVHIPVVGPFLALGAVTFMEQAPNLGRDLTHTALEALYKCRSCGHEAHVTYEITGPGNVHNEFGRYTKTYERPLVLVTDKNTSFLDIERVYRDMWVDYNFLTKNCRNWTKEITDRIWNLPSHNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ60</accession>
    <name>A0A914GQ60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQ60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10149.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10149.t1"/>
        <property type="gene ID" value="Gr19_v10_g10149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10149.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40281" checksum="917F7F10095B54E6" modified="2023-02-22" version="1">MSDNESDEEQQQQMEGIFICADVWHGVFAFLDPFELGLKMALISDRLDVLVDVHFKSREWSLGSLHICSIIGGNGAEIFNERSGGRLPIPQGPIPNKVIGFKCIQICYIDQTVVEFLRRFRRLFDSFGTNIHIATNDDESRSWQIIWQKIWPLVNDNICSFPLVPFHFKRLRQFSPSIFRNCPNLRSINSYGLLPEFPAEDNAEASSAQAVANWLITPRGDGLPKMLRCGFYSARMDGLKGAFVNASESANFIISFWHFSTLVIEPFELANALTRERLTLRRFNNDFWLLVRCPIGREEDKWTKWEEEAIEWLWYRQWNRLIVSFDDNGIGDGMIDANESPSELADGGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQD7</accession>
    <name>A0A914GQD7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1021.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1021.t1"/>
        <property type="gene ID" value="Gr19_v10_g1021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1021.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11535" checksum="85DD3028F0907D26" modified="2023-02-22" version="1">MPYSPNWTKSNGYCFPNVFIQHLEQALDPAFVDRADLVRRIGNPAEAAIQLILETAIEELQRRSEKLTQLTGQKPPPIEFDSFLNAFEKIAKNSSPFQWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQD9</accession>
    <name>A0A914GQD9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQD9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10454.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10454.t2"/>
        <property type="gene ID" value="Gr19_v10_g10454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10454.t2"/>
        </source>
    </evidence>
    <sequence length="896" mass="100571" checksum="9E584C9C0EC666DA" modified="2023-02-22" version="1">MADVERLKVAFQTCPPSSVRNVCIIAHVDHGKTTLADFLVSANGVISARLAGKLRYMDCREDEQMRGITMKSSSISLFYEPLLLNLIDSPGHVDFVAEVSSAVNLADIAILVVDVVEGVCSQTESLIRQALSRKLDILLVVNKLDRLVRLLESVNSCLSQAIHGQLLEEDWNTFEQMENQLHFDSSKGNVLFASALYGYAFAAEDFAELWAKRIIGPKCEGKEPSNDQLKRTKKQLNDNLFSSDHFFSANSKQICSGAEQRGKKPLLEQFVLEPLWELHRCALVEEDLEKLRQMSAKLSLPLLKGRRAEEAFTEMMRQWLPLSSAVVRACARMRSAQKAFQADDRIGQLFSSECEVDELTLVFCAKAFKLESHRVSLCRVMSGTLKIGDQLNVLRSSANSKSLVPGDAWHSVQIVRSRWSNLRDRGIRWALDWRANAELESVARHRVTVRPTNAGMDELNELRSALKQLSVLDSAVRVLEQEDGDLAMLTAGEVHLQKCLEDLKLLGQTEIVVSEPIVPFLETLIPDPRLSYAKIISGHKTECFLRQFSLRMTLRAVPLHDQIVQMITQNEKLIDSIIEGVSDPDSRHKLDAFQSQLSLCACNCLPKMKGSWWAKHSIAEIRRLFSRIWAFGPSRAQSNIFFNGCPNGQDENPISVWKGNLSSLDQAVVAGFHLAMSHGPLCDEPMQNIGIVLEEWEEDETEGNGISEGTERGETTQKCEDANSLVGGAQLQGQLISAIRQTCRVALKKHIGSLRLLAALYRCAVQTPTQSLGKVQAVLAQKRAKMLSEEFNELTGLFEVVAHLPVIESFHFCEDLRKRTSGTASAQLEFSCWQLIEEDPFWQPTTEEEVEEFGNRGFEKNQARLYVDTVRRRKGLPVEEVIVVSAEKQRNLKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQT6</accession>
    <name>A0A914GQT6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQT6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10465.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10465.t1"/>
        <property type="gene ID" value="Gr19_v10_g10465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10465.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11512" checksum="88E402F299E4EF33" modified="2023-02-22" version="1">MLERALSLFRPFGCSPLIGKTASVAVLQVRCNCPWHRSSYTPSFFPFRVNKKVKNDVQKRSQTEGGRHILMRRVLGEKHFIAWNWPSKKPQGDRLNYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS42</accession>
    <name>A0A914GS42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10760.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10760.t1"/>
        <property type="gene ID" value="Gr19_v10_g10760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10760.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38646" checksum="C7CB87B55BFEBF19" modified="2023-02-22" version="1">MSDYKSDEEQQQQMKKIFICADVLLKIFGFLCPFDVGLKIALTNYRFNTLVDVHFKSGKWLLGSMEIRRATDENGAEIVNARSGEGLPISQGSLPDKVIGFKSIVISYVDQTVIEFLQRIRPLSNSSGANVWIDNCDQSRSWEIIRQEIWPLVADNIRGLRLDPSVLGRLRQFSPAILRNCATLQSIYSLGLFPEFPAEDDAAASSRQALAKWLLTPCGDGLPKMFHCDLYLGGIDELIESFADASESANFIIKIWKDGRRFVPFELKNNWTREQLSFRRLNNKWLLVRCPIEREEDKWAKWEKEAIEWEMGRQSNCIVITDIGDGMDAANEGPNELNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSH0</accession>
    <name>A0A914GSH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10345.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10345.t1"/>
        <property type="gene ID" value="Gr19_v10_g10345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10345.t1"/>
        </source>
    </evidence>
    <sequence length="614" mass="67859" checksum="A243B88BDD6E829B" modified="2023-02-22" version="1">MNILKIEPKEEPFDENEPDGQYSEVSALKSAVEIDVKREFLQQSPTGNEFGDVRLSDILELSDRELAKRIYQAETGIKYLYFVLIKKTEQMRFMAKARKLKSTFMEQNPSKEGTLGHSRRKSLANFDPSCADYRALQRVLMSDEERAEMYRKRSQRQRERKEQMTEAELEEERAKARQKAGEKRARMNAGQRKMANRRRAERRRRERERSGNESPEKEAFEIAGTEMAALKWSVPSSRPFLHYKSECFTSALSIHFSSTGHTSFRLMGSALLHQTSCSLLFIVAVLLIYRGCPAEAELNMDNFACATKDSKLSAGMSYTKDGQIYIDSSAGKQSTLWDIRGFLKDGKDNKLIITVIGGASCGDSLKNVNIKQEGGGGNCRPGVASAVSSSHPVKDCPGCKSFTITCPVNMASVEGLPDARVFKVNLKELSLLSKPPCNWKGAFIDNVQFMLDNSNADNSEKCVEPGFPIMIVAIVAGVVGLLIVVAMVVGFLIYRRRQQTPPPTIELGTKTASPMEPSIAAKSEKGASMWTFWQGGAKTTKQSVLDGPKTQWQSKGSTATNMGTSKAKQSGVEMTKFGASTMKTKQSGVEVPKSSVSKSGVTMPKSVALKTVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTK7</accession>
    <name>A0A914GTK7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTK7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11099.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11099.t1"/>
        <property type="gene ID" value="Gr19_v10_g11099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF200">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11099.t1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44136" checksum="993739603D616AB3" modified="2023-02-22" version="1">MEPDFALYDARTDYDAIYNAQTEDVQQHQNVITHFFNQLLSGKKLRDMILPVHILERRSLLEMYADSFAHPDEFVAADKENSAEKRFLAVLKYYLNSFFPGRRGNIAKKPYNPVLGETFRCRWTLPGTVPSSTTTTAGPFPGSATNQVTFIAEQVSHHPPISAFYVEHQQASVSCTTAIQTNSFFSGLSVGVEMLGKATLKLHRHNETYTITFPKAYGRKLLSTPFFELAGKVELRCEQTNYRAEITFQEAGFTFLGRPAHQLIGTVFKRNSAVMKLKGEWNGIIELGRRTGKGDYNYQHFTDVRAKSSVAKECVAVMEQEATESRKLWRHVTAALFNNNTDVATSAKKRIEQRQRDEAAQRAQMAQTWQPRHFARTGGTWEYLGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTR2</accession>
    <name>A0A914GTR2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTR2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11265.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11265.t1"/>
        <property type="gene ID" value="Gr19_v10_g11265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11265.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="20053" checksum="EB6242E5136E81B6" modified="2023-02-22" version="1">MSFGLGRAESVTRLSEFEPRANPSLYRSSSLIDANRFTREIDRFSPHSASLAQHDSSSLWSSRMYRPSFVMDNHWFDKYYYFSPIYKGTQPYKCHVASHRLTFPSSWHQPYDYWRRVQHFWYDSDNDYAPLYRRMYEPFYGESAYTQRFWHRYRSHLLNNDVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTS7</accession>
    <name>A0A914GTS7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTS7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11148.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11148.t2"/>
        <property type="gene ID" value="Gr19_v10_g11148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037456655" evidence="2">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11148.t2"/>
        </source>
    </evidence>
    <sequence length="185" mass="20799" checksum="3435685FA3028971" modified="2023-02-22" version="1">MFALFVFPLPLLLLCVLQRISAAAAEASAEPGMDVTKRMFSYADLMNNFGGPSPLDFVTGNGYYMLDEERPKREDEAVELLTAWKRSSPFRRGFLNGVLRFGKRMPGVLRFGKRGPQHEKKAVPESGSARSAPLRQKNASGAPLRLMLFLCFSFPLFHRSDRQMRHSLPFQPSFVASLVSPNIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV55</accession>
    <name>A0A914GV55_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV55"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11071.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11071.t1"/>
        <property type="gene ID" value="Gr19_v10_g11071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11071.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="30433" checksum="2EBE760330ED95A9" modified="2023-02-22" version="1">MFPFCTDGPANFAQNASSSQQNLRINFSDPSTWTPAKPAAVSRLFQRSYPKFGPPQPTNLKVSFDEAPVEHLTFMFGIFMLISMVAICTLFLMKLTKASADSSRRGLGGILPSNCSMVLWMPKSTDAHRHQHHHHHHRHRVAAPTAAAVHQHQQQQQHQHYHSRPSSLMILLRSSFSCGASSATTAAAAGGVPKHRRARNAGATVRAGRSCISVVSSSSLNPLLPPHSLAIITPSPSSSASAGGGFIGCSAADDGARGVNSATIKNCPPPPPYDDDDASAQTKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV58</accession>
    <name>A0A914GV58_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV58"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11479.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11479.t1"/>
        <property type="gene ID" value="Gr19_v10_g11479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="368"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11479.t1"/>
        </source>
    </evidence>
    <sequence length="567" mass="65435" checksum="E1CECB576148058B" modified="2023-02-22" version="1">MEALKMEFGNSTDPVNFIICLLCCFDEIVPFKLQNNLGERLMTRCSGKGKWLLVRCPIERDEDKWAKWEQEAANCCQGNSVDIYFGDRGTNDGPFSEEVRVLRAKIAQLERQQTINSPTSSSGGFNLAPQNAKRRRIEEVEEHEELVGRMREQMEEWKRITKLELENKALRTELEHQKLLIAHNALQTKLEQHQNKQQQSREDHEKLLNAQKNLMEEMKEQRKMDTLRQQQRQKETNDKIDWLNEDQQKLVSIDQFSRVQTTISDLEHKQKDDQEEFLRKMIESLKSVQAMVVADLGRLNMELQTLIATIDQQCNEREEKLNNILGQMLQKQMNELGNCWKKELEKGMNQLKEELSAKMEQYQNKQQQNIDAFTEAQNGNAGLIPQQNRWDSTACHDELKLTEPDRLIVQYTGENLTWRSIFAERPISKNNFGIFYYEVWILAKESAIHIGLGSKQMPLGTPVGWCKGTYAYGSHGYFLGHAVDGCRGRFFGGRPYIERKPKFGGGAIIGCGVDLATRQIIYTKNGQRLKTTGLLAPFAGELFPCVSLCYPGDKIEANFGPDFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVD8</accession>
    <name>A0A914GVD8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVD8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11541.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11541.t1"/>
        <property type="gene ID" value="Gr19_v10_g11541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11541.t1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41205" checksum="08B03AD9766BF266" modified="2023-02-22" version="1">MATSTEKTSTKVISTTPNPLASMKKNVDHFGINCTQIDFADDIAQFMLSISAPSLYGFACANFQKRYAHGKYPENYPEVAKHDQVDACAQVPTASFCNETLALYACYQTESKMSAVNMEIAQICQNHLGISMVAGFRTRICVHREAEKELIVVESILDFSFSDQSYKRMQKFSFKIGEITNGMEYAPIFFIEFGNKHQKSVVREEADGKAISDDLNKEKATIGARHPSPCDLMGDECELVKEIERKIADLLECCSPTNPGGPCICTLPTPDPKEFTVFPPSAIIKPVNTQNRKPDKVLHTKEQAQQIYEGYMEKCANCTPFLKKESNRAKRQAKTNLNKWPTFPIAIKFSKCVEKLLNGNSKRNKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVU8</accession>
    <name>A0A914GVU8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVU8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11666.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11666.t1"/>
        <property type="gene ID" value="Gr19_v10_g11666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11666.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46426" checksum="59EF2E6D0341E1C9" modified="2023-02-22" version="1">MSDNASKSEQQQQMKEIPFDVGLKMALISDRLDGLVDVHFKSRKWSLGRLRIRRAIGGNDAQIVNERSGDKLPIPQEPLPGNVIGFKGIMIRYVDQTVIEFLQRIRRLFDSSGTNVYIKNDLRRYSWEIIWQKIWPLVNDNICCFDLYSSDLVHLRQFSPTVFRNCAKLRSIESCGFFPEFPAEDNAGASSAQAVTKWLLTPRGDGLPKMLYCSFYSAKMEGLKGSFVNAAEPINFIIAFDPSPSAVIEPFELKNNWTGERLTLRRFDKYFWLLVRCPIGREEDKWAKWEKEAIIEFELKLHRNFINISFIESSDIGDVMLDANEGPSEPNDCADDGRAAQKFKQAVDPIDYGTCRKRLTRDKSGPNVPTLLAQRQTRCSVHREEHFAETHLKLANFLLTVWSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW05</accession>
    <name>A0A914GW05_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GW05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10918.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10918.t1"/>
        <property type="gene ID" value="Gr19_v10_g10918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000180">
        <property type="entry name" value="Member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10918.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="26973" checksum="FE97895B965CED58" modified="2023-02-22" version="1">MLSSMRGIDWYMNCSAAHFYLCSYNLHMATSRSAAGNALRTGNGGGPTKTCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICLDDSTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQESFAKARNWVRELQRQASPNIVIALAGNKADLAAKRMVEYEEAQAYAEDNGLLFMETSAKSSMNVNDIFLAIAKKLPKTEGGGGPSGQGRSGVDITTDTTQQRRSTCCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW37</accession>
    <name>A0A914GW37_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW37"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11878.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11878.t1"/>
        <property type="gene ID" value="Gr19_v10_g11878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11878.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13886" checksum="6BC706542645C996" modified="2023-02-22" version="1">MDGLICAFAQPSAASTQATVGHKQKEHRIKEENDSTDGWRLERLGLSFFGQNVLWKCRHVYDKNLRKHLELRGTEVEYVRMFLNLSIAVLAFDKCAKRTLHKASEHASSVYMQAGKHCAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWM7</accession>
    <name>A0A914GWM7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWM7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11877.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11877.t1"/>
        <property type="gene ID" value="Gr19_v10_g11877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07166">
        <property type="entry name" value="NR_DBD_REV_ERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="284"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11877.t1"/>
        </source>
    </evidence>
    <sequence length="854" mass="93187" checksum="2746DDAD37D8B775" modified="2023-02-22" version="1">MDFQQHQQHQHQQQQQQQLLLAAAALWPPQRAAAIASMLRNSENTAQPMNNTNNNNGNGRPVESVILAQLHQTPPLSAPSTVMRQIIQAPIASGTIRLFDPAQGLPLGASVPETLMANQQQHQQQQQLDQLMMAAAFQQMVERLRGMPPEAKFVPSGDNGMERAPPPNFGSVSNSSSSSSSSAHPPSSFSSSSAPLPPPPPPPPPQIKTELVKKSPPDNAEERDARQTFVPIPTTSADELIGHALGRLVEQMDADGAEADDGNFQEGPSSTDGTSISRTANEEVLLCKVCSDKASGFHYGIFSCEGCKGFFRRSLQNKIDYRPCTQSQKCQIVRASRNRCQECRWRKCIEAGMSKDSVRYGRVPKREKEKLREEMRRDSARSAMEQLGAELEDEKAMVDQLERAFAELGTEMRGKLHFFENSESAEAASPGGPLDARRYLQLAHWVCRFASRIRGFRLLRREERVRLIRDAHFPVLLLRLCTLRRFGSNLSDDKVSNSLLVGLATVPKCLMVPSQNGQFVERIVEFVHRIREAQPPVELCPTDRQLSLIAALCLCRSEGAGEHAAGALSASVPAGGDDHNGHLQLQLAIARRIHERLWQALNATLATDLLPFGPSLLRRDSMERQHLAAMLEALRQLRLAHRQCLASINCCNVPGELFTARNSGLAIADGGNTSPKTRDDSANACGGMPKRRKILVNAAGREDAQKEEHTVATVGDAGGSTVSSNIVYGTTTTAQQQPAQKQLMDDLPNLRRELQRPPANAAAVVGVAVATASSCSGGNANAVTVSPTADVSSTSTSYSQASSLRELLARPPILHVVVPQQQRRLVDATNADGADEQPLNLCVRDHDKRNGREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXN8</accession>
    <name>A0A914GXN8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXN8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12312.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12312.t1"/>
        <property type="gene ID" value="Gr19_v10_g12312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12312.t1"/>
        </source>
    </evidence>
    <sequence length="786" mass="89574" checksum="13E44D134C965AA2" modified="2023-02-22" version="1">MIVLSGNALLTAQKHIDSALHIDEDEEDEQEEEIDQDGEDTEKEDAFEGGMMSSIDRSAVQQTDEAVALVSFLDVDLNRAASPHSQWASESTSNMHPIVDTEPNPIRDAHEPNHIFHYSPSSHSPDDEESSQNGQSSSSAPINSILDLSLINLDKEKAIDDECDGGMTMPGGSSERTLDRFEDVRTIASSDIEVIRQMDDWSVTSSHTNSALQPNNTHQQVVQSPSLKELHQSRTPPELIKLDTTQLSQDQKIEELGRVNDNLRMTNANLMAKNKQKIAAESKLQSQFDEKEKQLNDLLDEGRKLSEYSGRQAKEIRKLKQQLEQLDVVSAARDSAVEELQEAHQQLQEQENVVEHLRDEIENSEQQMRTLQMELGDKTTHAENLEGKMRVEKTLKTTGRERDELAKENKKLAAKMINKKAQDQIVDERERGLEEDLKLQRLKNASANSRIRELEQRIERIQDANRDIAVEISNANSPLLNTISSLEEKLLGLERDNDNLARSLRQMSDQLNAQKKKHQTETEMIARNLQEERQNNAQKTEELAKAFNERADQQNHIKKLEDELSQSQREHTEKVCRLERKMEELEKDIKTKRDELTELQRRNCELQQRIIASTMERRNNANSLLDPLAQQQKRVGERANEEDETIGTALRRGEELLQQHRHFVHQQNGKIQPKLTIVAPSYQPQRLGNSSISSGHVSLDIRLQGEHSPNNNYSLDAGSAEYLRSELDLAHSNLFQLHERFENLLEMYGGCLETIEELKYDNEDLRKLCKEQALGLVDLQPAAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYF5</accession>
    <name>A0A914GYF5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12305.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12305.t2"/>
        <property type="gene ID" value="Gr19_v10_g12305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="22"/>
            <end position="43"/>
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            <begin position="116"/>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12305.t2"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <dbReference type="WBParaSite" id="Gr19_v10_g1274.t2"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZQ0</accession>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <lineage>
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            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
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            <taxon>Globodera</taxon>
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        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="54"/>
            <end position="75"/>
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    </feature>
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        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12295.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18039" checksum="4A9B9EB703F73625" modified="2023-02-22" version="1">MELFFFRHAEYERLYNCTGLDIDSIPLERRQFVPESIAKFGVVLSEMGAVQIRIFAQVFLISMINTFAGFLYFYMQNNNVNQWMITLVEFAWLHIHGFPPVIYLAFNKTIRADCRLMFVKLFQRYRIGHIGGVTVVHQPVTNLTNGASPNCEFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0K8</accession>
    <name>A0A914H0K8_GLORO</name>
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        <submittedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
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        <property type="gene ID" value="Gr19_v10_g12833"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of locomotion"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of sarcomere organization"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of striated muscle contraction"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Myosin light chain kinase"/>
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        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
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        <property type="entry name" value="Myosin, light chain kinase a"/>
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    </dbReference>
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        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Sallimus, isoform P"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4230"/>
            <end position="4295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4329"/>
            <end position="4489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="4261"/>
            <end position="4275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="4281"/>
            <end position="4291"/>
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        <location>
            <begin position="4330"/>
            <end position="4362"/>
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    </feature>
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        <location>
            <begin position="4394"/>
            <end position="4470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="4480"/>
            <end position="4489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12833.t1"/>
        </source>
    </evidence>
    <sequence length="4910" mass="546103" checksum="CA82746E620ED173" modified="2023-02-22" version="1">[encoded data, 4910 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0Q2</accession>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <lineage>
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            <taxon>Nematoda</taxon>
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            <taxon>Tylenchoidea</taxon>
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            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the apyrase family.</text>
    </comment>
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        <property type="gene ID" value="Gr19_v10_g12965"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005509">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GDP phosphatase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Soluble calcium-activated nucleotidase 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06079">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <position position="186"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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            <position position="187"/>
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        </ligand>
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    <sequence length="429" mass="48787" checksum="41C046FF3100F2D2" modified="2023-02-22" version="1">MRICETTSNFFHAAMSSSLRRQMRPPISFFVFDAAKRPKAKSADMTHPRHSNVLVGSTLAIWSLIFLLLAAFVSLQYYLPKAASSCLCPDGEFVGLTAEGRYNDSSFGKPQTLPDGRVQYELAVVSDLDQDSKVKGQDEWHSFLCRGRLFFHPDGHSVKVEWFDTAAAKHNLSSELSSGGRAMELSDLCVYDGHLLTVDDRTGVVYRMDDFKKMVPWVLLNDGPGNTIKGFKGEWMTVRDKMLYVGGLGKEWTTQAGDYKNNHPMYVKVITPNGEVSHVDWTDHYKALRRRVDIEWPGYMIHESGQWSDVHKKWFFLPRRASKLKYNDVDDEHMGKNWLLTADADFANIDFREIGVIRDGFRGFSAFQFLPNTADDVIVALKSEERNSKPVASYLFIYRLSTNEVLLDDERVGPYKFEGLIVGNFVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1T7</accession>
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        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Heteroderidae</taxon>
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            <authorList>
                <consortium name="WormBaseParasite"/>
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        </citation>
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        <property type="protein sequence ID" value="Gr19_v10_g13121.t2"/>
        <property type="gene ID" value="Gr19_v10_g13121"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZNF800"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
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        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="754"/>
            <end position="810"/>
        </location>
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            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
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            <begin position="524"/>
            <end position="534"/>
        </location>
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            <begin position="571"/>
            <end position="591"/>
        </location>
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            <begin position="703"/>
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            <end position="799"/>
        </location>
    </feature>
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            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13121.t2"/>
        </source>
    </evidence>
    <sequence length="941" mass="106392" checksum="162BC9B0AB6E1CC9" modified="2023-02-22" version="1">MSLNNIKDPAAQAPNFPASNCDDGAESVVRYYQGGTDEVKNLLKNECSVIYECSYCRSLFRSIINFVAHKRTNCRTLLSSVRAEQAELVRDSQKSNQKGHGEKDSDSVNNGPKKSARNTRNLNLRRFNPTTNLVRHIRAVNVHLERTNTDVEVQTLPRTMRKPVETSIVDGKQVIGQLPTELSMKSLPENRVALVMPRECSVRCGEMQLRRRRGTQMKARPDEGSVCELTSEEIEIIERIPSAMPVDFTTNHCEDQRCVSRGLLPFASLSSLAHHLAVQHQMDYSEEGLVKQSENKAFIKCFLCDVPPFYCLEDLQKHFNAAHSIVRQHHNRFRMEHTNAENNAKRKCLSQSNFRSLSPISQPKDEEDGEEVNEEAGDEEEMEESLELKKSKRKPFRRPILFTPMTKEEEKQQHFEAALALRDWVRKVGKVKPHEKILEEDEADEVPPLRNVVTDVEGRCFFDEEEARKIDRLLNSRTDATDKLVEEESSEDASEQKTFGTNDDEDDKNDGREGLDEMDGSHKNRERRSRKPNRKFLEGPVEEPRQLTENSKISRPAKPRTPTVPLDGSANIPSTSAAVYSKKSTPKTAGKTSLKRKSARRNVFKNRKRPKVSDILTKPKESSETMTNYSSIDGINAEKVERSRTPTPMSSSAIPMKDFVLPAQILFPGKEAVQTNGAEPPQLVSEMDSGAPTEEPQSGPKEGSAEQTERRDSVAPPQLTKECLPTMVTGRYREDLIFYTPKARAKIREEELRRLVSSSSGSSRRKQIFSSSELTESDGISLIGESSRSKDQPKTETNEKPSSPPPKPKDLVDDGFWQCGECGEVLKNIRDGRRHMVSHIRVMRMRCSLCDAGAFFCSDMRVHLMYRHCDKLSLAPDDFILPGVPCMSREKADLLTQLVDPYHPGRVMYTTGKIVSWSNPKAYFPDPKSERNILGPALPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1X3</accession>
    <name>A0A914H1X3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1X3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13140.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13140.t1"/>
        <property type="gene ID" value="Gr19_v10_g13140"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF46">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13140.t1"/>
        </source>
    </evidence>
    <sequence length="717" mass="79907" checksum="FA8B030A899E14FD" modified="2023-02-22" version="1">MIFGYDARPINSPQQKTNENANEPKESEILSKFDKLKVSSENFDKLRHFHGNIYYGAVKALVGQVGRKHYKQLTETQKQKLARCLDRIEASQKEVINAAKCLVESRKRQFGGKRMVERGRTIKKKEESKVPSLVQEGESKVPSLDQVGESKVPSLVQEGESKVPSLGEKENEQISETERKEKSGAILKVLIKSKRLLRYMGRVRKRKPRSLLSDQKRAVALKTAQEATIIKRKSLDRLVGKRQAIKEERKFKISSRLAAAPLASPSDKSVGSRITNLLVKLIGGRRGERTNERWQNVYGRLRRVVGEIERRKKFPGSKVFEKRMYDIVLDREEPSMSPEDRHSHVGLLQDGLKLIDLAIANRTKSSLHNVRLFSPRFMPLTPDKGGSLHNNSLLSPTLLAMYDEHDNGAIGNVPEMLRKAGVGEEERLGLIGTLMGVMGTTDKVEQTLELFRDLNVFNEDSLDVQQKEQCEQNGYTFARKEQIEKLLRDQAVDLGKLPELARFDVYDRMSLEEKEFALWASIEQIASGSALGQPQNGTLDGHLPQRRVKRTFATRVREPVILSPFAFTPIHGLAVLGPTILSPNSFSPSVLAPTILSPHILSPNIFRPQILSPTLMSPAILSPFVAHPYVLSPALLGSLILNPVILTPFILTPVAISPSILNPFALSPAIFSPLLLAPDIVSPQTLGGAIFSPVMLSPAILTQGYLMVSIFSPSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H282</accession>
    <name>A0A914H282_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914H282"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13322.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13322.t1"/>
        <property type="gene ID" value="Gr19_v10_g13322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="419"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="13">
        <location>
            <begin position="630"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="90"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13322.t1"/>
        </source>
    </evidence>
    <sequence length="667" mass="72648" checksum="9E647834C025E336" modified="2023-02-22" version="1">MYRVLLYICCDFQNVHSRVDTNVQVFMVRLHVTTALVIFACSVLPPLLATGGGLLGLLGEDKGESAWEGGNRHGGGGGGGLLAELIAGGRGGGHGHGRREEDRSGGGDENGAEHGHTNEENGTGEDGNGKGKGHGNGGLLGGVVGELGKTVEGLGKGFGELIEGVAGRFYAPDPNADIPPHVLRRIMRFCSKHRHHDKCKNHPDWVIDQGVLPGLAGLTDELLEFPRKLNFAIPVPRKLRLEYLLKDVPDELVKTLPIGLAKNLDAISSQMLVSRCTDGLCKKQKPEYLNLRASLAELESVTLKSSVPDKPIESIDLGIEVRQHRCYEVKKALIKQAGLEGKIEPANDGLFQHDILLTEVQSNAILTQIEHADENVRAIPDGPPELIPIDVAPSTDPGAAADGPASLPERSMRTKRAGNSLFMEVSPTEKWSIEQPIQFVLDNSLAASDKSAVRAAVTEIQSKSCIRFVEAAISPPGPHLKYIKYPNPSFCGTSYVGRVSPLNPIYLSFLCGNTMGVAVHETLHALGLQHEQVRPDRDNFITIFWNNMDPQRYDMFAVSPANKFSSYGIRYDFSSVMHYDSKIAARQFGLKTMTAKVNPEENDAKMGQRNGLSPSDVEALNRMYCKSQNCIDNNVYCGTWATQNKCYKNGSPDVWMAKNCRKSCAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2A7</accession>
    <name>A0A914H2A7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g13342.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13342.t1"/>
        <property type="gene ID" value="Gr19_v10_g13342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056456">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055938">
        <property type="entry name" value="DUF7516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098:SF0">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23335">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24360">
        <property type="entry name" value="DUF7516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80 second beta-propeller" evidence="6">
        <location>
            <begin position="289"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="7">
        <location>
            <begin position="610"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7516" evidence="8">
        <location>
            <begin position="893"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13342.t1"/>
        </source>
    </evidence>
    <sequence length="1338" mass="150338" checksum="36BADE34528272F0" modified="2023-02-22" version="1">MRLRLQLSPWAFRNAVTGVVWVGADEVFSVSDDHNLCRWIVSKTEGTFLPNPLKETIFPTSLHSSLFAGGLSSLSTDKHNLSVRSGKKQQRSAIHTSQTGNDLILMTASDGKVHLITSAGKIERSIDAHQGAAILARWNTSDPGGTGGFVSCGEDGSVKMWSRNGMLRSVLAQLGKPVYAVDWNGNSNKLVYCAGEECFIKQMKAQNAPTKWRAHTGLVLCLSWSAVTDLIVSGGEDCRYRLWDGQGRPLWSSTSHDSAINQGGLIRWNGPALVGGCANGQLLHAHVVERRLMWEQLEAVQTRKKVINIRDLSSEVARERLETRDRVVRFELGFNYLVVATTKQCYIFSAKNWNAPIIADLKEGAGPVSLIRLCEKCFLLVESSSVQLFNFEGRILSTIRIPSSPAGEPFTEQTAAIANDLIVLRDQAQHSLVHLFDPQNGRTAGDGPITHNLDVTELCVNMCGSFAERRVAFVDLNGDCFLSLVNCYESAQRTAKIGSLISCLSSNNSTNMLAALQDNQRLIVWTLPTVAFMDRDLLPSTQIELGNSAELGKSSTIVGFVGNTVNVRRSDGCLIVHYVPPFIAALIRCVQHGQWDQAVRICRTMKEEFLWATLAGLAGTEKNYKIAEICYGQLEEVEKVLFLSELRSQNVPQLRDAMVAQFSGQRREADTTLVNAGKAFEALMLNLGTFRFDRAMELATKMGRHLDTVLGYRQRYLGLLGRKETDHRYLKHHSEVEPMMADKFERKKHQRMATVVAKISREELLEFVRNELVCTIGSADAPVAIPVLITTFREDTNEDILQLAKKLGYPSIEAMLDSVDLSDLVEPCFTDLAKGAGNENPKKVFSYRVKGSPMIAHILSTIEESAHYKDMKAEKHRQLEVLIGDPKYNPNILMGKEHLLALIYNLGGQERFVDLTELRKVYEQVHGTELNRAALKKFFPTGQLKNIMDKYLYQDIELATDQNKNGSLLFRMKRPYKEICEEIVRITEEREKHKEEQRKFRQDRRNSKKPKGPAQQPKKLKVINPPPPPKPKPIPLVKSMVHRANDLYTDDPMLFRKIATVSVHGHAGGEEQCPTNGTMEDEGSENGIAKRYTTRVEGATYTDDEEECMNDGDGEGKDADQEYGLEMLETEDNSSHGSLVMVNTRAESPAVEQNGDDEAEAVEDRAAKRMVMVRRMLEERKAFEEQVKMRNEVSGEVKGVFTETKRSGRRAREEEARRERVAKLLKRMESKMAEMEPMLVNDRLNEKSKRRIAVLVVELIWANRELGVSEVKNMLALLFGRIVEIDVAQFVTTYCKCLKFVRAPVEPHIVIVDESRKQIGKEIIDRGRKMNKKLLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2F5</accession>
    <name>A0A914H2F5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2F5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13516.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13516.t1"/>
        <property type="gene ID" value="Gr19_v10_g13516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13516.t1"/>
        </source>
    </evidence>
    <sequence length="453" mass="50184" checksum="5C73D267149364E8" modified="2023-02-22" version="1">MVRKRLPPELIYEITRCVRAHDGWFGVYASTRMLQNFLSLRLEKWAEIGLINIFSRLRAKEEAALQSGSGINLTHKEIRDVFMIEKDVNDLRSFFTIFKATTPGIVMTKFVGSDPSVSLFYDTIHTFLQKYSTSRNAPPPLPTTPIPLNVPRLSLPARGPNADQTHGIERPVSRWLQANRLPASIQMYGEPNIAPVSPVRRTPQSDVGSAVSHHSVTKNRPQFTTKVGRPSTSAPKPPLNRPSASTAKVRDDSLHTSVNVVPHGRPSASTAQIRDEPCAGITLHTSTHGPHARPSAGEKKSDFAETMQSIVGLPFQTKLSSAGLIYAHYGKAVIGSILGLPAEDADVGKLYEQIYKKFVEAIDAIDNGVNQFDGLPRYQLSSTFGSRVEHCNPAWNEEAPDPEKGFQKAMAIVEEEFEQRVRSLHTAWLPARNIVLAAVENRNEAKRGRQYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H376</accession>
    <name>A0A914H376_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H376"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12840.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12840.t1"/>
        <property type="gene ID" value="Gr19_v10_g12840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12840.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14907" checksum="9AFCCD5376E6F38D" modified="2023-02-22" version="1">MEGHDNPNFEFTIAQGVAHWSIHQYHNKLRIKWLTVETHDEGAQQPGERRRWLLPAEGRPLGTDEAQYSDAEVAVLFEVLEEDAAVVKDAMRSAENLDKQRMPALSRSRRDRTSGGVEDEDATGLLLIVDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3H7</accession>
    <name>A0A914H3H7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3H7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13306.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13306.t1"/>
        <property type="gene ID" value="Gr19_v10_g13306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF17">
        <property type="entry name" value="PDF RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="124"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="429"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13306.t1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57405" checksum="5FE1F2A4EC637D80" modified="2023-02-22" version="1">MEQCFDALKNSGLPVTAVPSEDGSSMPWCNATWDTVLCWPAIPGGQAVSLRCPPLKGLDTTKSITKFCHPSGRWMGKTDGDFSRLHGWTNFTMCFTQEVVAIMQNMDNGTLLMAQEVAKNVRNVAILSCFRRLRVFRNLLHLHLMVALLAVVLIRLVLYIDLIFTDRMGHQQLVNPHGKTINTMVFVCELMFFLLEYFKSVAFWWMFLEGLYLHNLLVFAFFTKTPKLWPYLITGYGVPLAHTLSWLIVLLVKKDGKLERCLGSYYLETVFWILDGPRLLQLVLNTFFVFNVIRVLWLKVRDSHQPSSEINRMKKSVKAALTIPFSPTQENITYFAIWTYCASLSYMYQGFMIAIIYCFTNREVQSVLHNCYTRHRLSHSRTPHRSSRYAPMASPYTQIRNNSSSLGANGTATVGSKDTVRMGGVNGGDCLLPPPPPHSNGTSSRMSEVGADSGTESMIISNRRKPMPMILSSEPEQRENDFIDQFASPQLARRGQIAHGRRQSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3K5</accession>
    <name>A0A914H3K5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3K5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13828.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13828.t1"/>
        <property type="gene ID" value="Gr19_v10_g13828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF248">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13828.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33928" checksum="9F68A719F2A7DF32" modified="2023-02-22" version="1">MDSFNWIGFGFGVILNGIMVHLIVRHTPKSMRMYSKILLQTCATDLAFLTINLLFHQYMFTTDKGESEVIPGGLITFNGPQNRGWNLLAWVCCIFLVYVSMFGYVAQFIYRYLLLNWDIKLSTFKYFILFGTMLFFPFVYCAIGFICYYPPTDHLYLEDQSVADILALNITDHIALTGHSFNDWRLTMGSYYFIIACTIAYIIMITLAFLMDKLLKGRLKLGASSAQTIKMVEMNKQISRNLIIQASMPFFIYLSVLFLLGIMLFQIDNAPEFDVPESQLDQNLVFRETNIDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3P1</accession>
    <name>A0A914H3P1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3P1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13554.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13554.t1"/>
        <property type="gene ID" value="Gr19_v10_g13554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13554.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="26512" checksum="1013FA64E349F8A8" modified="2023-02-22" version="1">MTKEEDEAKARAEKEEKKKRKSKDKKKSRKDSTKKSKKGEPAKEKSAKKDAVKAPEKPKAEAAKPAPEKPKAEAAKPAPEKPKTEAVKPAPEKPKAEAAKPAPEKPKTAPVQAAPEKPKTEPVQAVPEPPKTEDAGAVTDAPKAEDAGAVTEETKTGDAGAGTDAPKAEDAGAVTEETKPEDAGAGTDAPKAEDAGAVTEETKPEDAGAGTDAPKAEDAGAGTDAPKAEDAGAGTDEPKAEDAGAVTEEPKPEASEPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5F0</accession>
    <name>A0A914H5F0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5F0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14330.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14330.t1"/>
        <property type="gene ID" value="Gr19_v10_g14330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14330.t1"/>
        </source>
    </evidence>
    <sequence length="439" mass="49215" checksum="EA33E331B61C605E" modified="2023-02-22" version="1">MSKSASLVGRMKHLLDTGNGADVQFLLLPAHKLILMAASDVFEAMFPFDAQNANAAVGGKEIKLVEVPDVEVGAFKTMLAFIYANDLRGLNGDNAMAVLYAANKYIVPGLAKVCVNFSMLELRNVSSRFTVFASLENIQTHIVTSKTASLVGRMKHLLDTGDGADVHFLLLSAHKLILLAASDVFETMFRFDATTAGNAEQVKPVQVPDVEVGAFKTMLAFIYADDVSGLNGDNAMTVLYAAKKYDLPLMIEACANFPLSKLRNIFHAFVDARFVGENEISRRRLDYIDRNANTLILSETFLQIDQKLLCEILDRDQLQIDEEIAIWDAALRWADEQCRQNGKEPSAENRREMLGPAIFKIRLPLIPPKDFTKIIVPSRVLTSDELVSVLLYHSHPDRGCPGLYPLHFRNQRRARIESKRHDTRRRRNVESFECRTLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5J0</accession>
    <name>A0A914H5J0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5J0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14193.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14193.t1"/>
        <property type="gene ID" value="Gr19_v10_g14193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14193.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13557" checksum="BFE448B4FBF31C1E" modified="2023-02-22" version="1">MISDKGIVPELHLDSEDKEIREKVQKDVEESCKKFDNEEAKIILLNNVHYDLAINFEYNQRKEVYDRAQDLLSNWVGNDVTSFSSGIWTLSEKLYLKENASQMLQLVKKIIKKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5J8</accession>
    <name>A0A914H5J8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5J8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14378.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14378.t1"/>
        <property type="gene ID" value="Gr19_v10_g14378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14378.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38525" checksum="A70A0E71D7964B52" modified="2023-02-22" version="1">MSDNVSDEKQQQQMQEISICADVWLGVFAFLCPHKLGLKMALISDRLDVLVDEHFKVKEWSLSWLLIFRATDGNGAQIVNKHSGERQPIPQGPLPNKVIGFKQIKISYVDQTVIEFLQSIRRLFDSSGISVWIGTSCYESRSWEIIWQKIWPLINDNIYSFVLADDQLDHLRQFSRTVLRRCANLRSINFLGLSLEFPAEDNAGVSSGQAVAKWLLTPRWDGLPKMLRCVFSSTGMDGLKGSFINASEPVNFIISIWNDWDYRLVPFELKNNWTAERLTFRLIRGYWLLVRCPIGREEDKWAKWETEAIEWEWSRQRNFIAITFNDRDIGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6I8</accession>
    <name>A0A914H6I8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6I8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14468.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14468.t1"/>
        <property type="gene ID" value="Gr19_v10_g14468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="287"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14468.t1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56065" checksum="B73A4B3DD2AE80FB" modified="2023-02-22" version="1">MSFQEHSLEPQRKEQPLPDQLLLYVVVEVSLSKCRCRRVVVEVSVVEVSIVEMHLLIRKPGEFWGQEVEKCLYDNNKRPYIDGKLPFKKDDVIGCGVDLAKGQKIIYTLNGKLLETPDSRVDSATKLYPCVSMFMPGTKIEVNFGTKEFLLPAHKAILSTASDVFEAMFPFDAQNADPSEEIKPVEVTDVEVGAFKAMLSCIYADDVSGLNGDNAIAVLYAAKKYDLPELVNSCLNFPIPELNNVFLAFAQTRFLGEEALRWADEKCRQNEKEPSAENRRAMLGPALFKIRLPLIPQKDFTENIVPSGVLSRDEIISVYVYHSHPDVGLPELYPMQFPTNGRAVTAGNRSVFAVQPIPKNPFGIFYYEVETIRRSGSGGVIIGLGTKQMPLNRWVGNYKGTYAYASWGYFWGHELEGFSRHVGCPYIEGKPEFEDGDVIGCGVNLATRQIIYTKNGHRLETAGLRVDSAANLFPCVTLRDHGEKIKANFGPNFKFNIAADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7L6</accession>
    <name>A0A914H7L6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7L6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1396.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1396.t1"/>
        <property type="gene ID" value="Gr19_v10_g1396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1396.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10132" checksum="B4E7989838E3F4AB" modified="2023-02-22" version="1">MLNFFPNRWDPTACHGGLSIIEPKRLIVQHKRKNYVGDVVGCGVDLATRQIIYTKNGRRLETAGLFVDSAADLFPSKIEANFGPAFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H826</accession>
    <name>A0A914H826_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H826"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14678.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14678.t1"/>
        <property type="gene ID" value="Gr19_v10_g14678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14678.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22410" checksum="35F865D2F342266E" modified="2023-02-22" version="1">MAHSQPQLTSNEYYVQKVFNENKKVIVLQGLGKLESMAVIWKYDAQQTVVDHEIRREFLKKNASNVHIMPQFDTRSVLSNPKTRLLISECDSRSALDAVHAQKPLLCMPMFAEHFYVAEKLRRAGVAVVLAPHDSARITADALVNCINPWMQNMQHTKSRPHFIDKMKVLHDEIENEKIDPAELFLKAFEEIGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H861</accession>
    <name>A0A914H861_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H861"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15109.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15109.t1"/>
        <property type="gene ID" value="Gr19_v10_g15109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037204803" evidence="1">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15109.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22610" checksum="5FD41303F187CDB1" modified="2023-02-22" version="1">MEKFWLLILVAFFVINSRDKAESVQLEELQLQTFDELFVDEWWDKDEAAEDLQRPPPTNFEQNVQHQIDRQNTQIGQIEPNSTDQNPPLTEILLSQSLITLDKLNPFQLIRILFSQSLITLDKLNPQLIRILLSQSLITLDKLIPFQLIRILFSQSLITLDKLNPFQLIRILFSQMNLAKPNQTINTPTANKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA34</accession>
    <name>A0A914HA34_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HA34"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15616.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15616.t1"/>
        <property type="gene ID" value="Gr19_v10_g15616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000145">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000155">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF93">
        <property type="entry name" value="GALECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="5">
        <location>
            <begin position="148"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="5">
        <location>
            <begin position="288"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15616.t1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47423" checksum="478CF4AC824B2913" modified="2023-02-22" version="1">MSHQYQLSSHYGVSDDEFDYMMEQQQLNVDDQPHVQQVLPVEGLGEQPEEQFHDVLEVVEPIIVKEMVQEMGDIELKTDLDHPQQNGVNSEVDLVRTDNEIVQQNVEEHPQEDTEHNREEVSTPTPTNTAKLTLSDLMAAESQYPIPYRSKLTEPFEPGQTLIVKGKTAEDSVRFTINLHHSSADFSGHDVPLHISVRFDEGKIVFNTFTKGEWGKEERKSNPYKKGDDIDFRIRAHDSKFTVFADQKEVKEYEHRVPLSHVTHFSIDGDVLITQVHWGGKYYPVPYESGITGEGFGPGKTLLIFGTPEKKGKRFHINLLKKNGDIALHLNPRFDEKAIVRNSLIANEWGNEEREGKIPLEKGIGFDLKVINEEYAFQIFINDERYATYAHRVEPHDLHGLQIGGDVEITGIQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAB9</accession>
    <name>A0A914HAB9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAB9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1552.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1552.t2"/>
        <property type="gene ID" value="Gr19_v10_g1552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF8">
        <property type="entry name" value="FORMIN-HOMOLOGY AND ZINC FINGER DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="661"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1552.t2"/>
        </source>
    </evidence>
    <sequence length="1029" mass="113797" checksum="F9B1C784969245CD" modified="2023-02-22" version="1">MDGLDGWISTGGDVLCLSAAAAASFLNFLTFKLSQSAHFVDLSKDANRRNSQSVNRRHSLIITKVTGRRRRRSERRRSRIANSEKDARGGGGRWPRRGSVPAFILRSSNANANASSSSFRLLFTSDKRDFAFASSCPDDGTSPDNNASFFLILLLVSSLFLSFLNSEFVRLIRTNRQRDEIVSQQPQTLKTNSSTMAMDELTALSLSLNGGQQPQTPATIEKLLQISRQFLSGRNEISGDGMGKKNAQKRAMAVGIGNGETSPRGEESNGTERDGTAKGGGGGARGGNGDGRKRSYPYTFQFCVLCQKNVHSSKLPCHIRQCHVGKPMFQCPVCDFTSTYSKNNVKSHMVSLHGLAGDPISYMDQYASQVEEFMKQCFPNVRGRGRPLHGRLSPARVKQTVAANDSRSLVVTISPPTMSQSQQRRLSPATANAGPSSSQQRSGGRQQRTTTTNTQQQQQMADDQPMMVVGRAEAHHHPLLNGNNVDGGALLPFDATDVYGAAMGMLKTTTGNRTPTSLVPNKDCCSDPSLSNFGKGAAFGPLPQRDCGFLSAFNPFIYLQQLNNLFALNAVNPNGHQQQMPAEVKMETELDMPVDEDALHQQQHRLNASSMFSLEECLNLSQKFLKEMSKCEEPANIANCEANDVKSDASKELLICHSSSSNTSPHPSGCFPTNSSASVGAVLREEVPLYFPHQLNLTVLDGPVLEKTVFKTFANSGELIEKFDLSVFEPFLDQNSGSLLSPTQHQNVTSVRKQLGLKSFEIMFAVHRLDIDVLKPENVHLVMQIAPTDLDIRRFRLFEQSNSLNSLDEDEQFVVQLSKIDRLREKISVMALMGEFDQRVAQLNKHLLAHSVAAKLLFNSAEFHTILHVLLTCVNLVNGDFASQLVKGFRLLRLPEMCSFRFPDGSTLLKVLAQILRRHFPDDLDTFLKRTKVVEEAAKVEFAHFLRELRCLERGQSLVEEELQLCHGKNPQLANFLTHCELECAQLRECIQNTNCQVLSTMEFFGECTDEALGRAVIAQFARDLRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAS9</accession>
    <name>A0A914HAS9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAS9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1487.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1487.t1"/>
        <property type="gene ID" value="Gr19_v10_g1487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF659" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1487.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16172" checksum="160E50BF13CC905E" modified="2023-02-22" version="1">MDELKKEFSGKQIWASVDETTDKKGRYVANLIIGVLDCKLNKPVLVAVKYLEKTNNETIARFVNDNLRTFISAENLLLFVTDGARYMIKAAKGLKMFYPNLIHLTCVCHGLNRVCEAIRAHFVDVDELIARKFLICNCKNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBD0</accession>
    <name>A0A914HBD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1551.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1551.t1"/>
        <property type="gene ID" value="Gr19_v10_g1551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1551.t1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38389" checksum="8B16D3DFFAA69257" modified="2023-02-22" version="1">MMEMESWRAFLPPRRPFSRPEIGAFIPNFFLSSSPTSSFPHPQLLPFLIPNFFLSSSPTSSFPHPQLLPFLIPNFFLSSSPTSSFPHPQLLPFLIPNFFLSSSPTSSFPHLQLLPFLIPNFFLSSSPNFFLSSSQLLPFLIPNFFLSSSPTSSFPHPQLLPFLIPNFFLSSSPTSSFPHPQLLPFLIPNFFLSSSPTSSFPHPQLLPFLIPNFFLSSSPTSSFPHLQLLPFLIPNFFLSSSPTSSFPHPQLLPFLIPNFFLSSSPTSSFPHPQLLPFLIPNFFLSSSPTSSFPHLQLLPFLIPNFFLSSSPTSSFPHPQLLPFLIPNFFLSSSPTSIHRLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBU4</accession>
    <name>A0A914HBU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16073.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16073.t1"/>
        <property type="gene ID" value="Gr19_v10_g16073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16073.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7429" checksum="1EB8DE6F9B5DBC22" modified="2023-02-22" version="1">MEGVSSVVGSGEADAEVADNQWKCGGRPPTNCLLPWERRTRDLDAAELLWKLLGGVAAEAPGGSCCGRAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCU3</accession>
    <name>A0A914HCU3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCU3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15430.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15430.t1"/>
        <property type="gene ID" value="Gr19_v10_g15430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15430.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8571" checksum="06CA39FE63BAAA30" modified="2023-02-22" version="1">MFRHFDKCKWLLVRCPIGRDEDKWAKWENEAAEWEWCHQWNRIHVNFNDSDIGDGLLDATEGPSDPKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD19</accession>
    <name>A0A914HD19_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD19"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15499.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15499.t1"/>
        <property type="gene ID" value="Gr19_v10_g15499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15499.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32485" checksum="D98EBBFA8C12F07B" modified="2023-02-22" version="1">MGWELGDLQIRRAIGGNGAEIVKFVECKFERLLPIPQEPLPDKVIGFKWLTIRYIDQSVIGYLQCIRRLFDSKGTNLFIRSPGIQNRSWEIIWKEIWPLIKDNICGFYLLSSELGRLRQFSPTILGDCPKLRLINSVDVFPAFPADDSAGASSAQALAKWLHTPRGDGHPKEFINSTYSVNFIVCLWNCSAGIVEPFELKNNLTGERLEFRRFNKDFCLLVRCPIERDKDKWAKWEKEAIEWKCHRQWNRIWIVLDDRRGSIGDGMLDANEGPSEAKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD44</accession>
    <name>A0A914HD44_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15934.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15934.t1"/>
        <property type="gene ID" value="Gr19_v10_g15934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15934.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14614" checksum="D8B92F1FD467218F" modified="2023-02-22" version="1">MFFPMGPSQDQGMQQQAQALASRKARDDFFTFVAYGIVLEIGATIMEATDDHQLNNFMQQIQAEAQKQGLQEQMLSLNSRCFDICFTDSRPPSKMDGKSQTCLANCVNRIFEAKQFMFEHLQKSSSAGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD83</accession>
    <name>A0A914HD83_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HD83"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1628.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1628.t1"/>
        <property type="gene ID" value="Gr19_v10_g1628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1628.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20228" checksum="260E25CA1ED5196C" modified="2023-02-22" version="1">MFLLHPPPFSSLLHPPLSSSSSSSFLSSSSSSFFLSSLSFSSFLSSSSLLHPPPLSSLLLLFQSFFFILLLFPLFFILLLLPLFFLSSSSSSSFLSSPPLSSLLHPPPLSSLLLLFPLFFILLLFPLFFILLLFPLFFILLLFPLFSSSFNHSSSSSSSSLCFFISVSRLFCYLIDIFRCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDC1</accession>
    <name>A0A914HDC1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDC1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16457.t3">
        <property type="protein sequence ID" value="Gr19_v10_g16457.t3"/>
        <property type="gene ID" value="Gr19_v10_g16457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16457.t3"/>
        </source>
    </evidence>
    <sequence length="74" mass="8105" checksum="1C781F6D19E8E299" modified="2023-02-22" version="1">MHPTAWMESLFCESFLDGVRFLLNQTDPNGERCVGKNTTRTYFGMGNGGGDENGKKIKAVLALFNIVLTLNAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDH2</accession>
    <name>A0A914HDH2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914HDH2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15620.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15620.t2"/>
        <property type="gene ID" value="Gr19_v10_g15620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15620.t2"/>
        </source>
    </evidence>
    <sequence length="556" mass="62676" checksum="83F1EA5B24697C98" modified="2023-02-22" version="1">MSKAADFKFIPSKPAQSFGRFGKSKDQLGECARLATENGQLVDDRAALGLFLALFMLLQAVLSVANYSGYQSPPMFGDFEAQRHWMEIAVNLPPKDWYVNSSANDLNYWGLDYPPLTAYHSWLLGRIAILVEPSWVQLGDSRGSEGPRLKLFMRLSVVVTMSALFAPALVQLLCRQRTEEGREDKMSNNRDKSTTAFGVVGAALLFPGLLFVDCAHCQYNHCSLGLFLWAVASLEKGRLAAAAFLFVLALNHKQMELYHAMPIAVFMFTRSIVHTDKRRPLLCSAIGQSLLNLLALASVVAVTFAVLWSPFLWPESGLALQVLRRLFPFHRGLFEDKVANFWPGNLFGHKLGTLLVLFACVPSLICLCYRPNASNLRVALTSNALAFFLFSFQVHEKSILLATIPALLLLTDERLRRPTALFLNVSLFSLYPLCLKDGVAEVLLLFFAYPFVLRLLLNSQCHQTDASSNSDGRRHLLHSTLFWATLVPSFAICVFQLLVRPPARLPHLFPMLNALFSFGVFVVYWLYLNIRMVVWNWTVFIEQKGRKTVENKRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDR6</accession>
    <name>A0A914HDR6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914HDR6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16571.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16571.t1"/>
        <property type="gene ID" value="Gr19_v10_g16571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16571.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20209" checksum="926D0B73FFAE638D" modified="2023-02-22" version="1">MDEKLLRNEVAACIRSVEGFPSKGVLFRDIFPLFLKPSLIRSLCSHIVQIYLGQVDVVVALEARGFLFGPMVAQEMSVPFVPIRKQGKLPGPVLSATYVKEYGQDILEVQKGALSAGQRVLVFDDLLATGGSLNAAFQLIRQSNAEVQAAFVIIELEGMNGRMNQITVSDRYQPQSTMNNCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE47</accession>
    <name>A0A914HE47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related protein Rab-27A</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HE47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16671.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16671.t1"/>
        <property type="gene ID" value="Gr19_v10_g16671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16671.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24260" checksum="8F1BF82CA3C8B61D" modified="2023-02-22" version="1">MADYDYLIKFLALGDSGVGKTSFLHRYTDNSFTGQFISTVGIDFKEKKVVGWSWFIFSGFGGRGQRILLQLWDTAGQERFRSLTTAFFRDAMGFILIFDITNEQSFLNVRSRYTRTPRRPTSFCAATNPTWKIGASTARAKQLADQLGLPYFETSACTSSNVEKSVDCLLDLVMQRIQVSVDGDNLPTEYMGAGSRITLEEDASNRPSGASYYCANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HED2</accession>
    <name>A0A914HED2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein AF-9 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HED2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15845.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15845.t1"/>
        <property type="gene ID" value="Gr19_v10_g15845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15845.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27748" checksum="87031462762C1003" modified="2023-02-22" version="1">MRVRHDANRPQKEALARHFTFICYAFDGLHQCLYGNKAVLLQLKNKENHTHRWTLYVRAYDPEEDLGHYIRKVQFRLHESYPNNVRIVERPPFEITETGWGEFDAQMKMYFVDVNEKPVTAFHYIRLHHPLVTLKNGSTMVLKEHYDEIVFNEPTEPMYGALMKFHSYKKSPSFEQARHHLRELLDSQNKEIVGEIEDLKRSLKDACELMQKYRQERSEGARGEQPDEGQQSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFL0</accession>
    <name>A0A914HFL0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein amnionless</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16907.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16907.t2"/>
        <property type="gene ID" value="Gr19_v10_g16907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026112">
        <property type="entry name" value="AMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995">
        <property type="entry name" value="AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995:SF2">
        <property type="entry name" value="PROTEIN AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14828">
        <property type="entry name" value="Amnionless"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037617547" description="Protein amnionless" evidence="11">
        <location>
            <begin position="22"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16907.t2"/>
        </source>
    </evidence>
    <sequence length="584" mass="65643" checksum="A8356622713E9E29" modified="2023-02-22" version="1">MLLEALLLPLLFLHNFPCGVAVQFRWLPSAVLSDPNNWHPPGSVPCIGDNVRLDAAAGDEATDQNIAVAHLDGPLQVHKVLLPSNGVLYFGSRATEFGTATRAAAWQCEKRAEPKDAIFNAHQNAPNFFDHANWKILPEGSRQKMPLRASLDAERVPSEEDQVLFPEDTASKVFIDVPAQVRSLTMFGQSLSTRQLRRLLGTIEGQFRVRIGARLGTDVHINEHLRLRWPMDDDTVFTVVGDDVIGQQRPQTANWFGKPNSNFFEPQFSSLCGFVKCVPVEPFCAEPVQPVGQCCPQCGAFLRFRKNSLNFTLSLAVVDEAIRARTQMPNGMGVSLVRIDKDDFHPQYQISVLPDHPANFDESEYCSTMWSVFRKVQQRTINAHLSVEYQPSDSAEFFDLRANCSIQLGIVHWKAVFRALFLVVLLGIVLAIAIYAHYRRSPSFRLYVGNFWARQHNLSHVTWQRARESVELIRNVNEMEDNSAASFLAEFTNRAFSWKLDKKEEEEEAETNVGAHKAHHPVEDFLQCPSSVLAKNGAPQAMFIHHFLPAFGPCSALLQQSSFNHPFAHPNHLITTRAGRAKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGI2</accession>
    <name>A0A914HGI2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGI2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1675.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1675.t1"/>
        <property type="gene ID" value="Gr19_v10_g1675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1675.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24245" checksum="A8A7C149540780AF" modified="2023-02-22" version="1">MEWVEISNCTQCPENLKCLRPQFYRLPVLCLHEDIKNLTEFLREGPPETVTTTTASAIISPTTPSPPAAFPLLFWTTIICLLLAILLLQIITMTKAARDHLAKRTIRKGLSHRHRRQRPHQGPGHGIELNCVGRPPFIQAFPEPLAVNSRPAAVGMCSELSFHQQLNRQWALAEHAAQPVQNEVVNVCVATKQLEDIQEEDEEFERKKNFSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGX5</accession>
    <name>A0A914HGX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16853.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16853.t1"/>
        <property type="gene ID" value="Gr19_v10_g16853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16853.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12604" checksum="4D1EDEF833B83665" modified="2023-02-22" version="1">MSDNSSEEEQQQQQQMEEIPICADVWYGVFAFLSPFEVGLKMALISDRLDVLPQLKLLFANVFVKFLLFIWCPDVARKVQKRALREKDRASSVQSLCLSNGKRLEYLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGX9</accession>
    <name>A0A914HGX9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calcium channel beta subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGX9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16516.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16516.t1"/>
        <property type="gene ID" value="Gr19_v10_g16516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11863">
        <property type="entry name" value="SH3_CACNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000023">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046937">
        <property type="entry name" value="CAB1-4_N_A-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12052">
        <property type="entry name" value="VGCC_beta4Aa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="486"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16516.t1"/>
        </source>
    </evidence>
    <sequence length="582" mass="64389" checksum="B48C54096D1F01D8" modified="2023-02-22" version="1">MPVGSSANKYNNRRVSQDSNFSHHHDNDYDLEQRNRETIKSNAERQAAQQLENAKYNPVLFAVQTNVDFDGAIDDDAPVHGCAVSFKAKEFLHIKEKYNNDWWIGRLVKEGCELGFIPSPAKLEAVRQSQQSGKGAKFTSRQSASTTNLGALDRMMPTPRTGGSRGSTPPTPGEGDEEGGAGGGDTHRTGRSAGTNQQQMTPPVQKERKKMIFKKQENIPPYDVVPTMRPVVLVGPSLKGYEVTDMMQKAVFDYLKHRFEGRIIITRVTADISLAKRSLLNNPTKRAMMERANSRSSNSLAEIQAEIERIFEFARSMQLVVLDCDTINHPSQLAKTSLAPIHVFIKISSPKVLQRLIKTRGKSQMRNMNVQMVAAEKLAQCPPDAFDVILDENQLEDACEHLADYLESYWRATHPPVRSPPRIKRGPMANRGPVAAAFTPAQMMQGAHFGSPFYHPAGQPSSANDTPPQSQRVPTIAVQQASLPFAPGAASSSNAVHHEDEQYQQHHQQQQQLNNGYTPAGSSGRGGGGHSPRQHQVARGEDEDDDMDEFDEEMDDYGRGGGGGTRRTADLRRNVDDNIGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHW7</accession>
    <name>A0A914HHW7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHW7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17519.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17519.t2"/>
        <property type="gene ID" value="Gr19_v10_g17519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="523"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="579"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="642"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17519.t2"/>
        </source>
    </evidence>
    <sequence length="791" mass="90744" checksum="43530AA3DCF764B8" modified="2023-02-22" version="1">MELIEKENKRKGTKRRSKNCETLKQEEINKQIDDDITLPPRRRSARLVAISKPNSNGMNYEAAQPKLTRQAKEDKEELTKFGDDTPFFGSSASTSLKLTLQSPHLSSIAKSIDLPSKDGPFSASRPLEKKRKATKSFGEGTSQATLASSDDDGEDEWGAFELLHPSKADKKVIEVELDEKSSDLFKRRMNPLAERDAKEGEERAKWEHEMELEIMRKRRELQENTHRFHFLTYIGHLYFMANALLQNGPSFIERFAAMFEQTSAPLTPIQMRQFLTEEFRGKFRCQNDILKEPIKWCTTQDNFVRHLLTLIGHGTFSTAREIALIFFALCSFVLRLRARVCVAFNPMPRLMIEPKQGTKKTGKRKKNDQKAESARDGSSSDEQIAKGRSRRKGNGRTEVKAAESPEGAASLEAAYWNEYWDDVERRWICVDTFHCLVDEPQQIEHKFGVYVGKVRKILYVLSIDTEKGMREIGAKYVGDYLSAAVRKLRTDGEWIGQTMELPALHANENCSRLEDAQIYELLKSKPMPTVLSEFKNHPLYALKKDLLKFDAIYPSDIQPIGYIGKQRHEVFPRSAIHKLEGSLNWIKESRSIKAGEKPYKVVSARPKLNVPKEKREPLTLDLFGYWQTEPYVPPEVTADGRIPRNEFGNLYMYKEEMLPKGCVHLRLSGIYLVARRMDLEAVPAVVGWEFSGGFNHPILDGCVVLRKDEEVLRSAWQEMVREKAAKMAKRTAERVWKNWRRLIKGKMLLQQMRKSARLAVRAQFKSGTKESSSSPKLVRITTTEDDNNTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIX7</accession>
    <name>A0A914HIX7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. It is associated with the U3, U8 and U13 small nuclear RNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIX7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17804.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17804.t1"/>
        <property type="gene ID" value="Gr19_v10_g17804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17804.t1"/>
        </source>
    </evidence>
    <sequence length="379" mass="39101" checksum="E1F610521D7FAF12" modified="2023-02-22" version="1">MGRPESSPRGGGGGRGGGFRGRGGGDRGGGRGGGGSFRGGGGGGGFRGGGGGGGFRQSNGGGEGGGGFKPRGGGGGRGFSPRGSGRGGSPRGGGRGSPRGRGGSPRGGGGGAGMRGGRKVFVEPHRIPGIFIVKGKEDALVTKNMVPGESVYGEKRIAAPTDTPTNATATDGTPVPPTEYRVWNPFRSKLAAAVMAGVENTHIYPGARVLYLGAASGTSVSHVSDIVGPEGMVYAVEFSHRSGRDLLGMAKKRPNVVPIVEDARHPHKYSMMLGIVDTIFSDVAQPDQARIVAHNAHKFLKNNGHVVISIKANCVDSTAEPETVFAGEVNKLREEQFKPIEQVTLEPYERDHAVVVAEYRAGKKKVKKEEPLAEEGMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ21</accession>
    <name>A0A914HJ21_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17345.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17345.t1"/>
        <property type="gene ID" value="Gr19_v10_g17345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17345.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21712" checksum="4F9B6873A0F141F3" modified="2023-02-22" version="1">MICDTFEFNSDLCLLKLHNYVLGRHRAAGRLRERDVEVGGEEGEVFEPVEWEELPEQMAMFVRWLNEKMEDGEFGAGELAARAHHRLTFVHPFEDGNGRIARLLLNILLERRAFKPVFIPDELRVDYYRHLKDASKTGNCDEFVKFVCFLQQCADEGDAHEAGADESGAEWEELMRWMEMRRMDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJF7</accession>
    <name>A0A914HJF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g203.t1">
        <property type="protein sequence ID" value="Gr19_v10_g203.t1"/>
        <property type="gene ID" value="Gr19_v10_g203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3770"/>
            <end position="3790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2113"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2411"/>
            <end position="2469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2994"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3292"/>
            <end position="3350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3776"/>
            <end position="3790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g203.t1"/>
        </source>
    </evidence>
    <sequence length="3790" mass="428655" checksum="C2FB16A69F816F7A" modified="2023-02-22" version="1">MTRCVSAPPPEEHRRAVTLHDIATIATATQHALTAVDVHSHALLANWRTLLPPHGVASVTWPLQQPHAAAAALARSAFAASISAALRVIAIRHGGAFVVEQHHQQQKKQRVQAVQEESWEEIERRRQDEQMYCIRRENERKERRIVEEFEKLEKAEELQEVHEIGATKQSTKKYEEVQSVLEKEELTQHNNVNFKQKSEENVQKEKSAELFEQYREEWREGATYAEEEEEEYEESFFTQSLMTDIGREAYEEFVEISEDIERAGESAEFEQQFEWTRAESLRRQFQTLAEHRRQTDVQAETSSTLSELITVSRRSDSGFMDTIVHERPSAEESAHFSEVEQRTLHVNMERRRSREWSADATSHRRTRRKSSVHKALNATSVVEETAQPEEFAPVLKTFAGAAEHVRSQSGWAAAHAQSRFTDAQVALMQSMYKLPQTREMFTEHTLREKRDERARKVAKQASNEVSTLFRSIELLSKRTAEAEVWRRTAATCESKHLEVPEKSERASSSKLALASSASSYVKRLSLSSGEEELKHTQDVEIPAANAPAPRVIGFETCIEGLPSPFIRREKAVMRTESWPQLTSRAKVEEWLRKNEPEAFEGMEEEENVIAVPDSFQPLMASKSAGEVLDVSFRRWTKINAKADKRMAQQQQRIMQQLNAVAARYENMEQPIMLKSFPEQLKFGVILKTQNLASAEFYGARFYQAEAELIEQLEKDRQEAFEFEGATIWEKTEEFNERSFSVERKFASYQIQNNRPDEIFGVGVQRPERVEAKDERRLRLAHQKMAFQLVKQLLSAERGQVTLSEKQHAMVAEQFKQFGMEEMGMTIVLEQLAEVAGKPEAKVALKAWKSLEESMNVLAVLEEDIGLESTWTTGEIESGVEKSLKLARVEAVQHRAEEAQEELKTFLTALTGLEQFEEAKLIQRVPFKVSVEFKAPESLDEAAQIGQQLAKIEAIGLVRVLKQLPVEEKAEARRRIEQRQQVFELVRKMLSEERGQVTLSEVEKLLVSEQFRALGMEDTAASITLEQIQQIGGMPKAKIALKDWTKLEERLRAKEALEEQAKLQASLKTGAPKSETSRLLKIAQEEAVQVNLKEIKEELLTFLATLMAPEAWEAAKILQRSSVTSAVSAEAKAPTQQETESTTELVRTEQAYGTEVAKQAKLDAKEERRLRLEHQKMAFQLVKQLLSAERGQATLSEKQQAMVAEQFKQFGMEEMGMTVVLEQLAEVAGRPEARVALKTLQKLEERLQAITKEEEAKLQATLKTGAPKAKVEKTMKMMHEASVVFHSKSVKEELESFMQSLLAPEQWEASQILMKATWKTSAEFHGVAPKADEAWLIQQLERVEHMAIVGTVKPIQFAEKAEELRLKIEEQQHIREMVAKMIREDIQIVIGEKELEMVTKKFKQFGLQEGTAAVVLEQLQEVASTEKALGEKQKERAALFVKKLVEEVKQFTRVRKGYGNVQKEREKRVEQQQQKAFELVAKLLSAERGAVVLSAVERAEVAEQFRALGLQEILLKVVLDRMQQIAGAPEAKVALKALERLEKRLIEEEAKLQATFKTGAPKSETSQTLKIAREEVARLRAEATREEILTFLATLMAPEEWEAAKTLQKSAWKSEASVLAKAPTELETESHAEMIRPDEIFGVGVQRPERVEAKDERRLRLAHQKMAFQLVKQLLSAERGQATLSEKQHAMVAEQFKQFGMEEMGMTIVLEQLAEVAGKPEAKVALKAWKSLEESMNVLAVLEEDIGLESTWTTGEIESGVEKSLKLARVEAVQHRAEEAQEELKTFLTALTGLEQFEEAKLIQRVPFKVSVEFKAPESLDEAAQIGQQLAKIEAIGLVRVLKQLPVEEKAEARRRIEQRQQVFELVRKMLSEERGQVTLSEVEKLLVSEQFRALGMEDTAASITLEQIQQIGGMPKAKIALKDWTKLEERLRAKEALEEQAKLQASLKTGAPKSETSRLLKIAQEEAVQVNLKEIKEELLTFLATLMAPEAWEAAKILQRSSVTSAVSAEAKAPTQQETESTTELVRTEQAYGTEVAKQAKLDAKEERRLRLEHQKMAFQLVKQLLSAERGQATLSEKQQAMVAEQFKQFGMEEMGMTVVLEQLAEVAGRPEARVALKTLQKLEERLQAITKEEEAKLQATLKTGAPKAKVEKTMKMMHEASVVFHSKSVKEELESFMQSLLAPEQWEASQILMKATWKTSAEFHGAAPKADEAWLIQQLERVEHMAIVGTLKPIQFAEKAEELRLKIEEQQHIREMVAKMIREDIQIVIGEKELEMVTKKFKQFGLQEGTAAVVLEQLQEVASTEKALGEKQKERAALFVKKLVEEVKQFTRVRKGYGNVQKEREKRVEQQQQKAFELVAKLLSAERGAVVLSAVERAEVAEQFRALGLQEILLKVVLDRMQQIAGAPEAKVALKALERLEKRLIEEEAKLQATFKTGAPKSETSQTLKIAREEVARLRAEATREEILTFLATLMAPEEWEAAKTLQKSAWKSEASVLAKAPTELETESHAEMIRPDEIFGVGVQRPERVEAKDERRLRLAHQKMAFQLVKQLLSAERGQATLSEKQHAMVAEQFKQFGMEEMGMTIVLEQLAEVAGKPEAKVALKAWKSLEESMNVLAVLEEDIGLESTWTTGEIESGVEKSLKLARVEAVQHRAEEAQEELKTFLTALTGLEQFEEAKLIQRVPFKVSVEFKAPESLDEAAQIGQQLAKIEAIGLVRVLKQLPVEEKAEARRRIEQRQQVFELVRKMLSEERGQVTLSEVEKLLVSEQFRALGMEDTAASITLEQIQQIGGMPKAKIALKDWTKLEERLRAKEALEEQAKLQASLKTGAPKSETSRLLKIAQEEAVQVNLKEIKEELLTFLATLMAPEAWEAAKILQRSSVTSAVSAEAKAPTQQETESTTELVRTEQAYGTEVAKQAKLDAKEERRLRLEHQKMAFQLVKQLLSAERGQATLSEKQQAMVAEQFKQFGMEEMGMTVVLEQLAEVAGRPEARVALKTLQKLEERLQAITKEEEAKLQATLKTGAPKAKVEKTMKMMHEASVVFHSKSVKEELESFMQSLLAPEQWEASQILMKATWKTSAEFHGAAPKADEAWLIQQLERVEHMAIVGTLKPIQFAEKAEELRLKIEEQQHIREMVAKMIREDIQIVIGEKELEMVTKKFKQFGLQEGTAAVVLEQLQEVASTEKALGEKQKERAALFVKKLVEEVKQFTRVRKGYGNVQKEREKRVEQQQQKAFELVAKLLSAERGAVVLSAVERAEVAEQFRALGLQEILLKVVLDRMQQIAGAPEAKVALKALERLEKRLIEEEAKLQATFKTGAPKSETSQTLKIAREEVARLRAEATREEILTFLATLMAPEEWEAAKTLQKSAWKSEASVLAKAPTELETESHAEMIRPDEIFGVGVQRPERVEAKDERRLRLAHQKMAFQLVKQLLSAERGQATLSEKQHAMVAEQFKQFGMEEMGMTIVLEQLAEVAGKPEAKVALKAWKSLEESMNVLAVLEEDIGLESTWTTGEIESGVEKSLKLARVEAVQHRAEEAQEELKTFLTALTGLEQFEEAKLIQRVPFKVSVEFKAPESLDEAAQIGQQLAKIEAIGLVRVLKQLPVEEKAEARRRIEQRQQVFELVRKMLSEERGQVTLSEVEKLLVSEQFRALGMEDTAASITLEQIQQIGGMPKAKIALKDWTKLEERLRAKEALEEQAKLQASLKTGAPKSETSRLLKIAQEEAVQVNLKEIKEELLTFLATLMAPEAWEAAKILQRSSVTSAVSAEAKAPTQQETESTTELVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK93</accession>
    <name>A0A914HK93_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK93"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1900.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1900.t1"/>
        <property type="gene ID" value="Gr19_v10_g1900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1900.t1"/>
        </source>
    </evidence>
    <sequence length="409" mass="47006" checksum="094BCB2B7371BDD5" modified="2023-02-22" version="1">MLLSSFVQNEPLATLEKWEKPCQKLKEWAASCPSHFKTISSLGSITLDDLSRMPETKKSLDLMLEKLKEFPIEGMEELLDRRLKKPLKIAKLNCNKLLNEVEHSGLEDNKKYLENLLSKTSSIANGIDKEFMTFIFEVQLELIKKVKWTSGNKKELEHTFSNLHELAKHKKSYCRPEYEPGTPEFVECLGIRILNAKLGILKRELHAKIAGFVEQPHIDGDGFMTFSHNFKNEWNKIKQQMDQVNNNDIASTMRLYRKELNDLAKTAMEKTDLLKAIITEKLDQLITKCQNSSGKINEEEASNQLVATKEKGLFKNAMKQLLKPFKSDQKKQKEEAKKKEIYAMKNIINDSGMFDGAAYKLLVRFEHEELDTDDFCAELETAVEEDKQMILQAYQTAGQRVASNEVMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLV4</accession>
    <name>A0A914HLV4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLV4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17836.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17836.t2"/>
        <property type="gene ID" value="Gr19_v10_g17836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036732949" evidence="2">
        <location>
            <begin position="20"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17836.t2"/>
        </source>
    </evidence>
    <sequence length="536" mass="60137" checksum="DA2C177C3B6FB39B" modified="2023-02-22" version="1">MNFPTIAIIFSLLFCAASAGTCMSKSKMTQSGTMPRQKVHSRTLSDESLLDDAISYIHQTRRHNNASTGTNNHRAHHQPAGTKFASPGHRRSPAVYAGGGSRQERTRGKKPLLAHPKAQKNYALLMNSTPPPLPSVEDVLQQRRQQQHQKFEENNQSQRAWNNSTKVFDVATTTRVLPSSPPLTASSPSHHHRKQQNWQMERRSSKKSSSSNSGLNVVWEEKELDDNQHQQQQQQQQQQQHKLEKAQKNAEMPSTSSSWVGTGANGTLQCRDKTVLEDNRARMPSTSRRVGTGANGIDQLGHKGLVGQQQQQQHEQMKNAYKKARIASRTLQVGTGANVTLQRRDKNVLEDNRARMASTSRRVGTAGANGIDQLRHKRLGHKEKHEPINNARIASKSRNIGTDANGIDEHWEQKGLDDQHQQQQQQKMDVHNGKTASNPETASNPETASNPETASNPETASNLEMASNLEMASKRGFERTTSNGMDQIWEQMESENRMDKLWEEMESESESKAKNNKVKQTVGKKWKAKINNFKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMR1</accession>
    <name>A0A914HMR1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMR1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2925.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2925.t1"/>
        <property type="gene ID" value="Gr19_v10_g2925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2925.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29704" checksum="2E795CA8E3EF0AEB" modified="2023-02-22" version="1">MEPQATDTGRKLIALCKKTFSSAVGSLRAVTGQTISSASILRNARRLDSTPQLRVFRRSVTAFSALWTIVVEPTTGDIILIALFNLETAISFANMFTGIRNNSSCCFTCIIFCFKSCQKHRLRSRSISFSVCEEAKQVFEINVNRRTGSIFIGYAPKTMKFNCAVGRHNRSYSNESTGKIRGIAVPGCSYTVDGVPYIEGWPEFGRDNIISCGLSDTGRIVYTRHGQSLDTGDLFVHSEAELFPCISLLAPFDQIKANFGPNFAFMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNM3</accession>
    <name>A0A914HNM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3189.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3189.t1"/>
        <property type="gene ID" value="Gr19_v10_g3189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3189.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8012" checksum="E833DCD4107E6685" modified="2023-02-22" version="1">MKILLQLSEVEEDAERKARTMMVDVQRKVEAKVAYALHLAEHRLSTKWTKMHEKQEQPIRRSAQHGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ25</accession>
    <name>A0A914HQ25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3398.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3398.t1"/>
        <property type="gene ID" value="Gr19_v10_g3398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903575">
        <property type="term" value="P:cornified envelope assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033541">
        <property type="entry name" value="Dermokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36881">
        <property type="entry name" value="DERMOKINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36881:SF1">
        <property type="entry name" value="DERMOKINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3398.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="32835" checksum="26349660F6BEE4D3" modified="2023-02-22" version="1">MRMQDEQPPDPRTSVEEYRMSEFGVLLPRKSGKAIGKAIGKAIGKAIDKAIDKAIDKAIDKAIDKAIDKAIGKAIGKAIGKAIGKAIGKAIGKAIGKTIGKAIGKAIGKAIGKAIGKAMDKAIDKAIGKAIGKAIGKAIDKAIDKAIDKAIGKAIGNAIGKAIGKAIDKAIDKAIGKAIGKAIGKAIGKAIGKAIGKAIGKAIGKAIDKAIDKAIDKAIGKAIGKAIDKAIDKAIETIGKAIDKAIDKAIDKAIGKAIGKAIYKAIDKAIGKAIDKAIDKAIDKAIDKAIGNAIGNAIDKAIGKAIDKAIDKAIGKAIGKAIGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRV5</accession>
    <name>A0A914HRV5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRV5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3156.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3156.t1"/>
        <property type="gene ID" value="Gr19_v10_g3156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3156.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18869" checksum="3C4EC3FB370D76B4" modified="2023-02-22" version="1">MFANMSHAMDQPRVKAGDISSDEEFNSEMQQWEHELGGESVTGATANRKGVESEKLKSTQSNNRCVATKLKDRNRTPRNNGLQVHKAALNNGAVQFHMDVNSWAEGMRTAVVILLEQRLVEAGVEKYKPPHSIRNSDGEAHERAASLFLACRTNNRQCHLNALKGITNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS40</accession>
    <name>A0A914HS40_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polynucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS40"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4146.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4146.t1"/>
        <property type="gene ID" value="Gr19_v10_g4146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) polymerase central" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4146.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33052" checksum="3724D8CC13D3A291" modified="2023-02-22" version="1">MLLYPNASLPFLYEKFFLIYSTRPFDVPIQLKKLENASKLNLLPPINLTEAQMFVFTPSFPEQNAAKFVTYSTAKVIQKEIIGALNDIKSMGNWELFRLGPNKFDSIYGKVRLFHLVNCAGEVQIGTDKFCQFVDGRIRLEFVYEIGIETRLYPNYFGQTCQIPKHFEAFNGKGIVTNYCKVWLAGVSLASAPDDLGESLSKMLNGFDLAIKRAYLRFNPTKDGVQNEGQMSESDEIQTIYRKLKFDLKSMLLSRFRCHSVRLLVSAGMVNHSSANLSSSSSSSQPPSIRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSM0</accession>
    <name>A0A914HSM0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSM0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3391.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3391.t1"/>
        <property type="gene ID" value="Gr19_v10_g3391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3391.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13470" checksum="07FBAC44375C9655" modified="2023-02-22" version="1">MNKRGSTSPTGLDVIKKKIGYRDPYDRVTRCSSKKVPDDSATFAGGVTTYINSNGSAKCWGSDNTHNVRQLSPEIPDSPILRRISSLSSGSIELGQRARQLAAQAQRSPLSMNASPSLRPYLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT04</accession>
    <name>A0A914HT04_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HT04"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3691.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3691.t2"/>
        <property type="gene ID" value="Gr19_v10_g3691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3691.t2"/>
        </source>
    </evidence>
    <sequence length="309" mass="35532" checksum="3F48938B2D32C9E0" modified="2023-02-22" version="1">MCISILSMALYIAEIVTIVRHKKFYNSFYALFVMRAIPDWLGVLVSFYGNRLPSIFGAVLYPIYSQFPNWMLAFGLFLTVHTFLANNLVTAFILLNRLTAIIMPIKHEKLWRKFRPLITIFVYGVPTLLCWPVLKMDGILQLDDPNSTTDPSFAIYEAGDAPYIHYSLYISLLPQTETLSIILNENCGFMHWQHFWVTCSWQAYFCNLDGPKTKALLFVYYPLIMDTGTVMLASWLLLWASDTIRQQLIKDFSIIQKTNIQNNRVGPLEGPGNNTHRPQFRTTIATNFIIRTKLRIAVSVFFGNESLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUF1</accession>
    <name>A0A914HUF1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g428.t2">
        <property type="protein sequence ID" value="Gr19_v10_g428.t2"/>
        <property type="gene ID" value="Gr19_v10_g428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF10">
        <property type="entry name" value="GTL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1296"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1338"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1377"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1401"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1439"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1534"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="11">
        <location>
            <begin position="256"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="12">
        <location>
            <begin position="579"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="12">
        <location>
            <begin position="838"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="1307"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="736"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1008"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1959"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="736"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1061"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1967"/>
            <end position="1989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g428.t2"/>
        </source>
    </evidence>
    <sequence length="2011" mass="227756" checksum="2341A582B8A076D9" modified="2023-02-22" version="1">MSGVSAAEKNGESEERMEKISTSSPRAMSEEDTLVDNGTPIRNYQSMDQEPLNLNNEIPVEGDNVELRENASGKGPKRHRRRRMRYLSQNSMVGGRRPTLSRRTAKKNRRRQLCGPTAPPRHVHYHGELGLTQPIRASEKDLTRYEADVEEVQAREVSTIEGSLPTVATVGQHQQLPTRERDVGRMRHVSGGSSIQCEWIEETFNRRECSHFIRSSKDSNKREGPKRWSIHRHTNLAPTDAYGTIEFQGGPHPFKAQYLRLGFDSDPADIMCLFENVWQLEPPKLIITIHGGMTNFDLQPKLSRVFRKGLLKAARTTGAWIFTSGINAGVVRHMAVALEQAIPTSKIHNKIVSVGIAPWGLLKRREDFVGRDKVVLYHPQNFHPKTRLAVLNNRHSYFLLVDNGTVGRYGADIILRRRLESYIAEKQKLGGGIRSVPVVCVVLEGGTCTIRTVLDYVTTIPKVPVVICDGSGRASDLLAFAHRYIQEDGNLPEGVRPQLLSLIEDVFFYDKHDAHSLIMDILACVRQRNLLTVFRLGEDQKQDVDYAILTALLKGHNLSPAEQLSLALAWNRVDIARSDIFVMGQDWPKTALNNAMMEALIHNRVDFVRLLLENGVSMHDFLTIGRLEELYNTDQGPPNTLYYIVRDVVKIRAGYRYKLPHIGMAIEKLMANGFRSHYTSSQFSRQYSEYRNKLKESQRYSQSPIDLQTVSSRGGAYHRTGSDFFTRGFFRNFPSSASDSRLGESHTTATGIRPTGGQPQASQTQQRLHNSSSTSNYATMNAIPGNRALSNHILWRTAYRREGINNLGARQKSTATMIMPPANRELPNDAIEYATEVDEKQGTTEGQSSTTHEFIYPFSDLLLWAVLTKRHEMALCMWQHGEEALAKALVACRLYKTLANEAAEDYLEVEVCEELKTYAEEFRQLSLELVDHCYKQDDAQTLQLLTYELFYWGHQTCLSLAVIVNNKQFLAHPCCQILLADLWHGGLRIRSNSNLKFKSREELLLQPQTAAEHQKDINESSSSSSESSSSSSSSESESDDDESDAGERGGATVGDRRRTSHGSMQSLNFTSIFQSKRKRHRPSHVSSSTAIKEDIEMGKQKNRDCQCLLEPSRNTPMKDGRVAKNPQKRGVEDGAALSRGKGGVGEGVNALVAQSTLGAVVPSATNSTGGSPLLSHAPLPLNNSLNNAWTASADCHMRTDGAIRSDRTAPHFLLGSISENIDGIPPHSKNDYTKSHYLHGFGGVEPNGLSKNPIISRSFDQIGRLTANGGYVPKGIPLPEGVTLNKKRQIKFRRRLYEFFVAPITTFWAWTLSFIVFLSTLTYVLLIKTPPKPSYLEWYLFAYVVAFGLEIARKFFMSEPKKIKEKFEHFFGNYWNFVTSLAVIGFIIGFAFRLHTPTSKSVGRIILAVDSVLWSMKLLDFLGVHSRFGPYITMAGKMIMNMSSIVVMLVISLLGFGLARQSITYPNEEWDWLLLRNVFYKPYFMLYGEVYADEIDTCGDEAWDEHLDKNVSIANAWTHRDDRARELACVPGHWIPPILMTIFLLIANILLISMLIAIFNNIFESANKISQQIWLFQRYRQVMEYEATPFLPPPFTPIYYIYMCFKYINYRDWMCICCSLKLRENTLSRKKELKMAKKRNLGTAGRVSRSVKDGFALFDFSLKLFLSNDQVEKLHDFEEECMEDFAREKEYERNRTSDERLHRTCERTELILLRVNDITSKETTLKGNVRELESRLGLVESRQTESLQQQQQQLFQKLSMADSRTNVCPLINIQSPSKEVPLKTDEMSSQISTRQNEKHLKTDVLNDHQNKTHFLFPETRERRSKSIQNYEAGIELLLDQSGSAKGRLRTSTIAGTDYTSNAGISSDCGAMTSSSQHKFGSLISLGPARGAKPSLISPNLQIKKSTSTRKRYRQNEEYTSITDAIDIEFERSSSKAGSEVELDTKEAGEMHIYQQRERAIDAGMQTEYEEEEEDEEEDEDMMEEEDDIYGEGGSNNSAENGRRRVHHQFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVB7</accession>
    <name>A0A914HVB7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVB7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4125.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4125.t1"/>
        <property type="gene ID" value="Gr19_v10_g4125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14689">
        <property type="entry name" value="bZIP_CREB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051381">
        <property type="entry name" value="CREB_ATF_subfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996">
        <property type="entry name" value="AGAP001464-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996:SF3">
        <property type="entry name" value="CREB-H TRANSCRIPTION FACTOR HOMOLOG LET-607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037663861" evidence="8">
        <location>
            <begin position="18"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="321"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="315"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4125.t1"/>
        </source>
    </evidence>
    <sequence length="775" mass="87021" checksum="A698D39F39791C7B" modified="2023-02-22" version="1">MHGFNLFFLYSLNFISSQQHWDATKLGSIDLTPFSRPNLKSSYCIPANFGMDPSLAMLADNDLDHFLGSAASSPLNFDLDELYGRVKDEQNLQQTPTLHDHCYYELPFCGSPDSGLSSTTQSSVSNGGEGHNVVVAVESQIAERSSGGWPTHSNGYETDCSATATPSTPSKILLKREEDYEKTEAIDCQMLFVEEIGRVVETKTNIQFRPIATMLDTYGQNSLVPPIRQNGSFRLKGIQQGQFRRISCQSVAVRKMSAVGSASPNAIEFAESSLMDNDRISMMEHSKYPKLVLNEEERKLCKKEGVHLPHCYPLTKTEERELKRIRRKIRNKKSAQTSRRRKQDYIEALEERVDSCTRENSELKRQIEIMAAENKQLAAQMRNLQTSVGQSAKRNAQTGTCLAVLLLSVCLIVAPNGKHLGMVGTGGHSNGPYQRQLMMAQQRHQLGIEPNFRTELNGDQDNQQTVGAAHHRGASRTLIDFVAPPEAQCIEGNAREERQQLLGFTPADSAASFKAAASMAQALKQQREQQMEMVPMDEQQLTEQLQLEHGRQWKDLGGQFEEEMEDNPICQSPKMADLFSDYFDTEEQCKFYGNISDEPLEDFANVGMETDGNALTTMAQFGEKVPSFANAIKSHFGTEFELYDGMDKIGDGGNFLVVPIQQQNESDIDGMELAGLNGPEDFGRAETAEDKVVLLLLLFNWPYVFKSCRLFMCIFYSPQLQKQFKTIAPPPPLLLQSIQLLLSSRQQPAGECQWPSLLQDWTDAVHYLFFAKWHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW67</accession>
    <name>A0A914HW67_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HW67"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g433.t2">
        <property type="protein sequence ID" value="Gr19_v10_g433.t2"/>
        <property type="gene ID" value="Gr19_v10_g433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g433.t2"/>
        </source>
    </evidence>
    <sequence length="402" mass="44746" checksum="29CE5843AA668A5E" modified="2023-02-22" version="1">MNVHAIKMPKKLAMRREFATCGDLRANSLGHSVKCHRKALSTCPSFNQSHPFIACRNCHPPDAVAVLPFSFFAQFPSSPRAEHCDQFSDDPICQPISARQQHQSSPKLAQNCQHEDLWLIPGKADSSCTRPNPKRLAEVNARQIKILPPIVKLPGCFTIEIQNVRILEGGKVGGNIFAKTEYQWLNAVDSKSGDSKCQNASLNGCGGFGNNCYYCDICKTLRSIDETPDKSNLPPDIAKQFKGMNCPDKIGLYSFRKEFCFNDWSILDANRDCRLDFLESISPSAESDQIGNVQSAMAALQQVGYGTLVAKVRLAYNATPEIEAKRAQKEAQIERTVKKELERKRTECAREIGTKANICPGCCTVNVETNENEIACIRLTFDICQRQPQRKWDGVDGGYTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXD2</accession>
    <name>A0A914HXD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymosin beta</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4904.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4904.t1"/>
        <property type="gene ID" value="Gr19_v10_g4904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4904.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13536" checksum="237E39FD86836E10" modified="2023-02-22" version="1">MPEIHSPTAEQLPKMPTELQSEVAQRAGLKHVTTLEKNVLPTKEDLVEERKHEDLKKGIHTFDAHKLRHVETENKSVMPSPEDIAIEKTPQLAAEFDQSGLKHVETNVKTGVEVIDKTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXF2</accession>
    <name>A0A914HXF2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5550.t3">
        <property type="protein sequence ID" value="Gr19_v10_g5550.t3"/>
        <property type="gene ID" value="Gr19_v10_g5550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase central" evidence="11">
        <location>
            <begin position="1415"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5550.t3"/>
        </source>
    </evidence>
    <sequence length="1718" mass="201052" checksum="0C5D6D29EDF2293D" modified="2023-02-22" version="1">MEQHTYTEQPQRQNFQYYPNPPPPVVYERRYAERDSGPRCVPCCCCFPCIPIPLCFDCNFPPTNILYGIDRRNLDNEYCRLLFDAPLDHCAQMDIGTRLGALLVYESIETDLAIIDFRLGQIFERNKFLAAYNLNKSTIRTKFDELNTKIWNKKVGEKRFGMDNVCRLWSFGLEVTKLNDFLNRNQTLAEKEMNKLATLLKLNENSECKQLEKIENVFETKYGELPLWVGESEFSHTLRMLNGRGEIDQIVRMKQKMNRYLMEYKYIGMLELHNPLTMAFDIICDSILKTAFRGIIMFDGIMSDEMALQNKKWIEISLLCGKIIDYFMQQIQNAKAEVKNLSGEKEIIVPLKEKVDDQMPIPTLLECPDKNIPLEKLEQVDDEEAKKDDEAFSLMFLYKEAIINAGDNIDFHLHLIELHELILLPEEDEFRWSESDCADEIVQNKLISAFLKDRMAPTQFHLAAWDAVFRRFGQIRHFFCYGTDQIEVAIVKENFRYTFGELLLDRLELVHPKIMRFESPAYSHFLLLLLQQLSDKTDSVPAELAEARKYAPLLLLDLQFYEQNLEGDLAERKAMGEAIQSAKQNFYRYLIKMQRSKKHSIRNAFCVLFCSHGLLKRKMALNLKWNLIYAECEEEANVKETIAVQRHRMRGLTLNFLSQTIANKLFALPERIKAIRGGRTRLLKMLYDPDISFEQNEEKIANLWEAMHLDLSTIDYGDSELLISHYEEALLTDDDMIRIEGKMKAEICVFFNWINSQIFSKNSFLSAIRNNGRKYCDLSLQIIDDFYDQIFDERSAEVEQNEHILVDLIFEIKTQLEKILAGHSMKSSELELLKEWQKWHLNRLMDRKAGKSFVKAKHWNEYGPWMRQLHGIMFVQLLKMDKNFAQKLKNEFETSLMKKNYLIELLDIEKFVAVHIRTEEAAHSAERRHSKMPAFPALQQFGEENCENCNNWGVVAAHSLLKLLDIGILANEIWHSVEAIKALNESKCDERWANIEMELAHLTEKEFVVENAQNSNSEIEFCQQIRHQLHLRKFSMALFHSGRFWSNLSEIRRKQIVSTLFRVEDEKTIELFVGKVEKYLILIKKLNEQRNLDESLFNEYKNGLNKFVSKKAKKKLHSDKSTLPHEFAKNWQEINFVENSNRKSKQIIQIKNYLMANGYFSEAERHKNERIVSELTRIVEEWCPDAIVQFPMSLLGNEKLEPICILPEEIDRELIFGKLNFNFEMSEMGAKCEDKSLYCSLLMRSEFKSVQKIVKELTTLPTLKFNFMDVPIEMAFILVPKVKLANSGEPIGLRTYEKFAKYFAENIEHLLNADRYDEGIHMDEVKLQNIIRKQLEKSKSFNDKFELDKVLGELKQLTSTKEAALKQRQIVAEQKVMLLALSRNFISEKIVFEILSPDTKLEENSRGINKNERLRVALAYLELWAKNNFIHGRNMGYLDTPMLLIMMAKVFLMFPEASIPFLIEKYFLFYSKWKWPMPVQLAQIDDKRIGEFLSWGPGREWFTKRQFLAKNLRKTIGQALAMPIISPLFPEQNEAAQINLSTAKVIQNELKNAFIKIRSTDKGHGIIKPIAGNCKRFSEKYEHFVTFTCGGTKFNVEKFCHFVGKRLRHELLYFVENSLANWVRFCHVHPTRVPVEQSSDEQQQQIGGSNNNLHKNLWLVGLKLHKQKVQNKFVDELIDKLAEISAKIKKDFEGDLFYNVQLHSEYVEKSKLAKWISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXF6</accession>
    <name>A0A914HXF6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXF6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4924.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4924.t1"/>
        <property type="gene ID" value="Gr19_v10_g4924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4924.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14629" checksum="4F47090742B7E99C" modified="2023-02-22" version="1">MFRMESLRSPPTKKGAIELVQIVCFFPRMARHRFLYQKFRFPFRVDRLQLGVRTQRLPFLRPPNIIAAKHQNYQRQKQKMPPPPPTNPWRCGHCCLMDGKAFGCWVVALLEFVLLSLDWERAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXG1</accession>
    <name>A0A914HXG1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5556.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5556.t1"/>
        <property type="gene ID" value="Gr19_v10_g5556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="708"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="1260"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="404"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1522"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1531"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1577"/>
            <end position="1586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5556.t1"/>
        </source>
    </evidence>
    <sequence length="1586" mass="179604" checksum="FF06D26B6F4D00FB" modified="2023-02-22" version="1">MQNSAVAILVKASSDVSVKCNYNYEASSAYILFYWPRLFFTFVLPLTVIVTANVIILFKIRSINIIQGKSTSTVSSEVKCNNIILFVIPIVFVALNLPYNLRNILKFVLNSITNSAIYEQYFAFISNTLYLYCFNFSVNFIIYAMTSSMFRKALVSVCTHIKERKMDAATLQRVLDNVLAQSEARVQQMLKAATPANNDLANANLTNSIDARIGKFKYDPENGHTFDQWFKRYGKIIEEDGKELPEATKVRLLLGKMADEEYSKYRDSVSPTLPDQIKWAETLTNLKELFAETRSLFVRRYDCFKIRQQPRQDITSLVALINASCENANLSLTKEELKCIILVIALRDENHDLRQKCLKMLEDSRKTGTAITLKKVEEELRTIQLVKESALSLMSPSVATNAIRARPQQWRDSKSKPYLQQHGEQRSYNQQSGSSNSTEKGKLFRGPPTHPCGSCGLSNHWRADCRLKDAICSKCQRKGHIAKVCRQTTKAPPRKDRSFLSIGVQTHLMAMGTTQPRYWKILITINGVQNRMNVDTGAQATIIPIRTWIKLGKPALSPSDIDAKNCNGEPVPINGKFECVVKTTRSSPKTLTAYVSETIEQDLLGLPWIEQLEIIPTEILFQEVRTKARCNPSKTASQHPTNVNDAQSLISALQSDFSEVFSSDLGRCTKAKAHLILKPDAKPVYCKARPVPHGAIDAVNDELDRLLKIGAIKPIEFSHWAAPILAVKKKNGKTRVCIDFSTGLNNALELNRHPLPRPENIYAALNGAAYFSNLDLRDAYLQMELDTESQQLCALNTHRGLFQCQRLPFGVKSAPSIFQHLMDQICAGIPGVFAYLDDGLIATKTLEQHLSAIYQLFTRIKEFGLRIQLEKCKFLQKELLFLGHIISAEGIRPDPSRSKAIRQMPPPHDVSTLRSFLGALNYYGKFVKEMREIRAPLDQLLRKDISWNWKAEQQTAFEKAKEIMTSDLLLTHYDPSLQMVVAADASKDGIGATISHIWPDKSEKVIEHASCTLSDAQQNYSQIEKEALALVFAVQKFHRMLFGHKFTLLTDHKPLLAIFGSKKGIPIYSASRLQRWALIMTNYDFVIKYVNTAAFGQADVLSRLIANYPRPEEDRLIANICTETECYISTVLQSQTDQLPITAKEIAEVTAEDEILSEILRLSRSGWPKKVNDPEFAPYFPKRDEIIGIEGCLMYQQRIIVPSLLRARALKTLHMSHPGIVRMKALARRHFYWPGLDSAIEKVVRECEECQNALKAPTKAPLAPWPPTSQAFQRVHIDFAGPCEDGHMYLILVDSFSKWPEVCLMNTTTSSATIKVLRSVIYRSGVPEEIVSDNGTQFRSAEFAGFCKEFGIKHTFTPPFHPQSNGQVERFVDTFKRAMKKCAKGDKLWAEKMLLSYRTTPSAVLNGHSPDQLFFGRKLRTTLSLIHPRGEQREFVDQKDIRKSQLKYSSQMTKQFDEKHGAKPSEFGPQDPVLLLNYKLGKAHWLPGTIVERVRHSPTYRVLVPSLGKRIVHRHANQLRRRLAFEEDGPTTDREPIPTVHADENHQPPKDQQLPQGSPPLAVRRSRRTIKPRTFYSPPPARKSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXS1</accession>
    <name>A0A914HXS1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 12</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXS1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5011.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5011.t1"/>
        <property type="gene ID" value="Gr19_v10_g5011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5011.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19715" checksum="0E1FC22022DB6474" modified="2023-02-22" version="1">MDVEELVVEQSLSELEQNAMARRQRLMEFRAKFANNEQFRKEGEEEEGDGSRGTEEPVSLLFRSYKRAKDSDGTEKVPQPHFGKTQMEIGALEKNISDQLEASEDTKIHDELDLKTLAPRKVDWDLRRGLQEKMDKLERRTKKAINQLIRQRVDEGVEGQLAAAVDSVGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYC5</accession>
    <name>A0A914HYC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5239.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5239.t1"/>
        <property type="gene ID" value="Gr19_v10_g5239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5239.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12478" checksum="54B407B112D4B113" modified="2023-02-22" version="1">MRGKEMARRSKETNRVEQTIPGEGQQQQKHEEDRGCWNVANRWEMGFSNLSAKFAMIDKRLESLEQSWRSAVPFSPHASVAGTSAMSFDNAEKRFLLCGNARGGIREIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ54</accession>
    <name>A0A914HZ54_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ54"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5133.t3">
        <property type="protein sequence ID" value="Gr19_v10_g5133.t3"/>
        <property type="gene ID" value="Gr19_v10_g5133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="292"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5133.t3"/>
        </source>
    </evidence>
    <sequence length="537" mass="59172" checksum="C9705CEFD6CEB91E" modified="2023-02-22" version="1">MSNSSIRSTQSDRFLPEISASNVISSHCLSMEEHQQQLASSDQLPPASVAGTSSMTGGGGAQLTCTVCGDVATGRHYGSVACNGCKGFFRRTIRRGYKYTCRFSSNCQIDKHNLRDEGGRRPNGTPGLAISPPAASGAPTEDESHGPQSPEPGKGIFAQQKMERHQFDNFESSSVVAPSNSPCPTSANSMLPTVHFMSRHQHCNQQFSSLEESDEPVPRKRSFSSGSKRQFQEESSRETDCVTAVDVEQRHQQQVASATPSVDNHSDNPWSGRNGRALLRQLLCSEEKIRNMRESVIAQTCNLEYINKGEPQRPQVPIDGNGTRKANENDILQSLHSQLLLVIEWAKTLKPFAELPTEDQTALLKNFAAQHVVLCVAYRSTSDFLTLINDSCIPRIANGDDKDLFYRKDAERVMDLLVSPMRFLRVDDVEFVSMKACILFNPVARGLSPQSVMSVLQTRRQIFQALQQYVQAKAPPDEGRIGDLTFFILSPLQSLAKAVSEDVLVSKLSGVARLDQLMEELILEGEPGGGEGIIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I029</accession>
    <name>A0A914I029_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I029"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6247.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6247.t1"/>
        <property type="gene ID" value="Gr19_v10_g6247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6247.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29007" checksum="7C092F4FB2A0DF81" modified="2023-02-22" version="1">MAALPAVACASLTRTPLAAHLQRVRSAVQLVWERRGRRKGKEKKWKKVKCHGGKAKSGEKCQARKRQKGKCQQEPVPKEKVQKGEMPRGKSQKRGNSAEWEKCQKAKCQEGTVPKGKVQKGEMPRGKVPKGKKGENVKRKRCQKEKCKKVKCHGRKAKSGEKCQARKRQKGKCQEEPVPKEKMQKGEMPRGKSQKRGNSADREKCQKAKCQEGTVPKGKVQKGEMPQGKAKSVKQCREGKVPKGKMPRGNGAKRKSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3I8</accession>
    <name>A0A914I3I8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-binding domain-containing protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diphthamide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein DPH6 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Diphthine--ammonia ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914I3I8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6492.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6492.t2"/>
        <property type="gene ID" value="Gr19_v10_g6492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Diphthamide synthase" evidence="13">
        <location>
            <begin position="147"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6492.t2"/>
        </source>
    </evidence>
    <sequence length="262" mass="29128" checksum="6806A8D8EA747D78" modified="2023-02-22" version="1">MKKNSCWQVLDLVAVSDKDMKVVGLISGGKDSCFNMMRCVEEGHELVCVANLHPPTDVSELDSYMYQSVGCEGIKFFAEALGLPLFQRQICGHPKSIESNAYVRDDEDEVEDLYHLLKTIKEWDPEIRGVSAGAINSTYQKLRVEDDQLELLDAMIAAGVKAVLIKVAALGLATRHLGQTLEQMREHLLAMHAKYGLHICGEGGEYETFVLDCPLFKRHRIAMDSASTEIHFNGAQNDDICPVAYLKLGKLALVDKDDGPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4D9</accession>
    <name>A0A914I4D9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6503.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6503.t1"/>
        <property type="gene ID" value="Gr19_v10_g6503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="798"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="881"/>
            <end position="968"/>
        </location>
    </feature>
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        <location>
            <begin position="1014"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1201"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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            <begin position="1622"/>
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            <begin position="289"/>
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        </location>
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            <begin position="304"/>
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    </feature>
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            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
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        <location>
            <begin position="424"/>
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        </location>
    </feature>
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            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
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        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
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        <location>
            <begin position="717"/>
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        </location>
    </feature>
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        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
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        <location>
            <begin position="903"/>
            <end position="951"/>
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    </feature>
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        <location>
            <begin position="1023"/>
            <end position="1044"/>
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    </feature>
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        <location>
            <begin position="1073"/>
            <end position="1096"/>
        </location>
    </feature>
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        <location>
            <begin position="1143"/>
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        </location>
    </feature>
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        <location>
            <begin position="1201"/>
            <end position="1225"/>
        </location>
    </feature>
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        <location>
            <begin position="1300"/>
            <end position="1324"/>
        </location>
    </feature>
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        <location>
            <begin position="1358"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6503.t1"/>
        </source>
    </evidence>
    <sequence length="1672" mass="179614" checksum="FC295BE0B92D10E4" modified="2023-02-22" version="1">MDANYGRKMITFPNHFCPNPPPSYPFFSNHHHHYHDDQRGSTVDDQMLIHYSALSSSNKMKPFLHRNNNSRNKTRRPSSLFVTEVPPAAASPPVVAKCCLLTTPPRTKITLPPFTGGVDGCCVNNKSFLSSATIEAAAPLQLKNEEQKELFSVLNRQHNPLFVLPSAGCPPPSPPPTRRKAAAAAVTGQQSPSPTEKDNGHRRPLCYSSTTTELMVAEEDGDKNAFVASSSANPSMAVMVANRRRSGGEDVLNGRGRVVVTRPPSYAEYMAALHAPHEKRGEDVVCDDSSCGSSSRSTSTSRRMIGRGGRRRRRRLRGRPTSDEGEFHYHHHHRRSAAAVNGRRRLITVDASCCSSNSSRSRTNNNGDDEVDWTAGVEVEEDDRRGQHQSSSSSSSSSSSYAHHQSNSSTSPPPPPPPFALLRDRRRGRRRNNHHHQHLLSRCRTNSSKKSSSSTTTTILTAERNFLIDKLLLHNSNNSAAGGGIKVVGNNSSSGSESGTAGGVVVGGRIKEKKEKQTPKGGAGGGQEGQQFVLLLDEFEEEKVRRHQQRQQQQQQQQQQRVICGDHCRLTSSSSTTTTDCQHQQHHHQTTTEWQEYCRCYNNNNKNEDTDAGGQGGDLVKQFLTPPAPRSASFEQQHQMKITTANVVSCGSGGCGSSSSSAAETEVHDEAEQQQQAMMMNSNDDIAGGEKSSSSSSNRMNTNNNNNNNNNTEPSQDDNRVADMKKQQKIMTTNSLAVANGNNNNNKSLRAKSTSKLGQLLRTMLSVAGREKLSDNANPPAKTVQPNEQNDVVEGNDGGIEKGTPEHGSGIYVKNVIEGSPADVDGRLAPGDQLLSVNGQSLIGVGQDLAAKKIVSAGPVVHFEVAKQAAQANGLGPYFQQQKHHQNGAGSTTTTTPQQQNGHGDGGVHQQNGHGGGGVHQQNGHGGGGVHQQNGHGGGGVHQQNGHGGGGVHHHYSQSKQQQQTAAVALRASIRNSNSSNLRASKSQQLMMNSSNNGGDGGGTGVPLLSVHPVVQQQQKQQRSLSASELGSRAENNNNMTSAAASKFKPGGHGHPHHPPGAVIVPPPPPPSSTASSSSPLPLVHHSQQSSTSSSSRLPAHYRPSVSRPQVVVMQPARPSAATSPLSVVALQQQQQHHHHPFNTSVISNSNSSISTTVADPSSLKSLMMMMATDQHQNMKHTQQQLVDYSHLPLITAAVTTTASSGSPPINSSTTNSTASSTTTTLEDRESSNNFINSSYGWGDQLGQLNKMPPSAALADEREEKLLHTTTKLVKSGRSSAPLFGEQYLQQIQHVPAVVQQRDQQSQSSQQSNNNNCSKQKSSSTMNATMTAEEVERELDQLDSIVVSAQQQADNIDDDRTGESSEQQEQDHRYRLLLERLATVRGSAASAPTTTTIMPEATMPAASNNGTGSGNINNKLPASMVAAAQHLERQSKSLAALSLDPGTKTSTTTASGAGWLTPSASSTGNLLKIKRVTNSQISEIINPHHQIGPNPSPPAPTAAAASVVAELQSRNRLQQQPPAVPAKPAIRELLQRQSPGASSVAASATVTAVSTAKKRVQFSIQNNENILLEVPTDTDEDGIKSTAPPPSAEEEEDDEPRVQIVGAHEVYVNDPRQRRLQELQANQQKKLGEREPSAEAYNQHKSSSAERRIVQQQQQPQMHGGDGEKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I529</accession>
    <name>A0A914I529_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I529"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6965.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6965.t1"/>
        <property type="gene ID" value="Gr19_v10_g6965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6965.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24563" checksum="541E194611327056" modified="2023-02-22" version="1">MANFCAMFEQCESACRDLAEELVKFYAFSAEYLLKHRHRCVDEENSVESDEELMNEELVTDDAAIVAERRALKAGASKKRILAADAPPTEATRVERRAKRRALRSNLVEELRAEMAEAPERVTDREETRANLRRADAQRRFEEAHFVRLSGAERKRQRLMSKANGDTGGDGETASDDRTNRREFRNSKAQKRPRHNDNSRKGKPKGEKKKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6C3</accession>
    <name>A0A914I6C3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SUI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6C3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7030.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7030.t1"/>
        <property type="gene ID" value="Gr19_v10_g7030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="482"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7030.t1"/>
        </source>
    </evidence>
    <sequence length="573" mass="63552" checksum="3FE438EFE2B2E405" modified="2023-02-22" version="1">MFRKQFTIKSYTNLRHSERKTIFPCAINSCFNAKQQVARILVTLPTSNVCLYVLDKEPLFFQCPSENTIFPTVYFLWSASFDGQFPVLFVHAAVLPILQNGSDLMLPGILLDHPFADFEANAPVAIAIVTEERGAPVGYGLVAVGQALISASELRTKRQAGEKGKAIKILHIYGDFLWEYGSKKKFGSKKLGTFGQEHAAAAQHGQVVDEHCTDHDQAVQSSSVSSVAAETVSEKCQEYGDEGVHEKENVQANMDELLKNTFFAALRWKFGPNGPLPIDAGQFYANYILKCLPPDRKLDIKKTKFKKFSTFLRELISIDDDPANWVVRMKSLKGVDTIEEFNINHPLVQSAPELVHNADATAGGSFVDGQPLLSIRDNVFSLTEKVMPIFRPSGFSKGDIVDLNRIRAVLGDYAQKENLYSNGGKEVRLDDTLQPIVQHFLYETFDFNKLVQKIASAMTPAILIKTKEDKQIVHRGTKQPHIDLKIEKRAGNKQVTLVSNLAAFCIDVNMLDSKISGTGTCVLASAPACDGPQLLVQGNEINRIGRFLADFGVPKKFINGLEQGTKEPKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8F3</accession>
    <name>A0A914I8F3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8F3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8440.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8440.t1"/>
        <property type="gene ID" value="Gr19_v10_g8440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8440.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="14907" checksum="B1C951977FD60621" modified="2023-02-22" version="1">MVNPSSPTPTPDMVNPSSPTPTPDMVNPSSPTPTPDFPAPEGSGRNPNSNVQFLDQDDDDDPDTELYLTQPFACGIAFAISVLNSLMSTTYFNESALTLIRTLVTGGATPEILIENLDRSVCSIASHGRMVERWHGVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Q8</accession>
    <name>A0A914I9Q8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9Q8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7914.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7914.t1"/>
        <property type="gene ID" value="Gr19_v10_g7914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7914.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21892" checksum="01FC5FF393C87F67" modified="2023-02-22" version="1">MAFELMGNLAIDGEAKSYGIGHLGAVQAYWDRTYPDMFRLVAFDKRTGLKPIFKGENVRKFDVCVITHEGHWDGIKSVSQFFKIKIRAQLPQYRIVAYDLETTKVKGEHQPNLVSAAVTCSVCSGEEKECESGRMCVARVYQMFFAVDYRAKWAVCTGKLPADGDTHGAVERRVRQNDPLRVMGMRSKGTTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Z7</accession>
    <name>A0A914I9Z7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914I9Z7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8870.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8870.t1"/>
        <property type="gene ID" value="Gr19_v10_g8870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF16">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="325"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8870.t1"/>
        </source>
    </evidence>
    <sequence length="572" mass="63131" checksum="CCF568A69C5B029E" modified="2023-02-22" version="1">MFPFFGVIREIACRVFGIEIGISVTGRTQRTIQMAVGDRVEEHVIFLIRMGQSISPTVFEKEKGQIGVKPTGSSPDKNSQFAQHPSPSSPPLPLITNSGAEGQFNVLFSTPKSTASSLSLSDQNLYEGWELRVTKTDLAALLPYHIVVDRDCRLVQFGKALYNHVSPELLQIGTPLVRTSPLSLQRAIGGEQQNNEEDTALTVNAQHLKLKGQMMLLSSGDELIYLCSPYVTSIPELLNYGLRLSAIPLHDVTRDLILLNQQRLSDVEANLQLEANNEQLELLARDLESEKSKTDTLLREMLPASVATALINGRNVDASEYPESTVMFCDVPAFQSIVPFCKPKSIVRMLNDLFTKFDRLVTLHNVYKVETVGDSYMTVGGVPEAISDHCERICHLALGMIWEARSVIDPINKNGLKVRCGLHSGNVVAGVIGIKMPRFCLFGDTVNTAARMESHSPHGLIHCSETTFRLAQITGRFEFVCRGNVPIKGKGTMKTFFLTRSFKKSLWEIVGCERDEGIDSIDGYEELAAGMDLKGAKAKTQRQMGDRQTVDGLHSDVKANKKFTGNVSESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB31</accession>
    <name>A0A914IB31_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB31"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g825.t1">
        <property type="protein sequence ID" value="Gr19_v10_g825.t1"/>
        <property type="gene ID" value="Gr19_v10_g825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g825.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16567" checksum="742D0EB02C7E1DFC" modified="2023-02-22" version="1">MEFLEDDGRPPMLDGPFAPARDESMAETNYSDASKDFRLADCLPILESVARAYDCIYPLPKLGRDHHMSGCLLIRSLSSANRLYIFEWEECLELKGHLEMEDGSSKRVLHEFYEKYDGIEGLGRFLRESLFNFFYLMYSAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBI8</accession>
    <name>A0A914IBI8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8688.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8688.t1"/>
        <property type="gene ID" value="Gr19_v10_g8688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015701">
        <property type="term" value="P:bicarbonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF47">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="692"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="871"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="965"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1024"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1095"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1119"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="12">
        <location>
            <begin position="135"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="12">
        <location>
            <begin position="374"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="583"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="509"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8688.t1"/>
        </source>
    </evidence>
    <sequence length="1174" mass="131840" checksum="51F46225D816273F" modified="2023-02-22" version="1">MDHSPTDQRHIRYENETEPNEISIPVTHMKKPDHHIKFRIGSDDLGVLQELLTSERSPVASNSALFAPRPNDRGPNSKPPPRMSSASSISTVDDSSEGLPMHRKFASEVSQAKQVLIELFDLKLKNGGRALLPHGSWEETARWIKYEEDVEGVDHQRWGLPHISFLSFHALLQLRKCIGKGVILLDVDVADFDELSGLIANAIATQWSEIGPQCKRIWATKQLTNILKLRQNHVRDRRISRISTTATSLAAHFWERGGAEKTQLMTPRRTISAMPLTTADIKGTAAEDGTSENGVFRFNGCSFTKSPPTITEDDESNTANNSIHRGQQLSPPPTKRKFSTPNCRETAPENGCQKTFFLKEAATVGGDDHAAPQEDIELVQVLVGELNWMHKPRFVMVRLAEGRTMPEIVETCHPVRIVFVILGPALSDGSYHELGRSLATLVSNPHFKAIAFGARDRSQLIEGLDSFLDGSLVIPPGEIVSKRLISGDILLKLHRRWQRERRMRNQQKVAAAEVERQQHEVEDIERDSRHQHLHSANDAEKCSCGGGGEPAMPSNGGGGNDQPNWGEKMKIAQRTKRKRHFPLFKGLQTDIASRLPFYWSDIRDAANFHVVFMFFACFVPAISFGGLMGKYTNEHIGTIETLFAQCICGIIWGLFAAQPLMIMSATGPVLIFEGSLYTFCETLQLDFLTIRFYAGLFIMLIAICIAALDGSRLLVFVTRFTEDIFAFLISAIFIAESLHFIWHTFKENPVEDYSYYEKIHVNCRRHVNNQSVGLQPNFAPLLTLPFDVEGIGNSSRNRTADSDSGRRLVNALAEIKDPMGTHRFPCGEAEPNTALLTAIIVFATFILALLLKKLRESFYLGRHLRRAIGDFGVLISITVVTLIVHWCIPDPYLQRLDMPDHINFTNPTRRSHGLLVAPKLPFSDWRGILVSLIAALLVFILLFVETEITELLLSRKERGCRKGTGMHWDLVLMGICAFLCSVFGLPWMCAAAVQSLAHCSSLTVMKKTAPGARPEVDCVIEQRITTIGVALLIGLIAFGGSYLRLPLASLFGVFLYLGVMNLCGVQLIQRVVLFFIPEKYFPVTPYTEQMSIWRMHLYTWIQLVCVFIVYTVKYFKKTALAFPFVLMLFIFFRQIILPKIFTTKELEAIDGEGHSENEDWSSKEFYDSPPPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBM7</accession>
    <name>A0A914IBM7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBM7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8443.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8443.t1"/>
        <property type="gene ID" value="Gr19_v10_g8443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09804">
        <property type="entry name" value="Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8443.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38357" checksum="2FD49219A8F1F7CC" modified="2023-02-22" version="1">MSIAEDNNRKNIENIRRIDHCAKKVIEHCTHAALFNFSIEQNKWLKTEVDGPLFIYERSEEPLYALLIANRQSPRNFVEPITNGLQLRYESPYIFIHREDGSIRGVWVYGEDDCRRVFNMLMNLCSALKHATDGVKQYMPKKMAVVAATQPPPSSVANERQQSSKAAAVHGNGIGTPVVVPVKASGIGTPVVVPVKASGIGDDGPSLVDKDANNTATEKQKIGKVSKVIVPLLLDDDVVEIGAAAGDDDRNEEVVELEEDTAVVSSSMSSPPRATSGQQQQQQQQQQTTPEAFMMAASPPPYQDVGTHLRPVTFGDLERLKRELMDGFRQMLSNELTKFMETRSSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC86</accession>
    <name>A0A914IC86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IC86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9489.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9489.t1"/>
        <property type="gene ID" value="Gr19_v10_g9489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9489.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="16118" checksum="FE4799A63123E53C" modified="2023-02-22" version="1">MASHSAGGEGAAGGPLPPAERPATPLEGRERLADPCPQQNGQPLRWRGGGGWRTPAPSRIASHSAGGEGAAGGPLPPAERLATPLEGRGRLADPCPQQNGQPLRWRGGGGWRIPAPSRTASHSAGGEGSAGGPLPPEERPATPLEGREQLADPNPQQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDG6</accession>
    <name>A0A914IDG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9593.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9593.t1"/>
        <property type="gene ID" value="Gr19_v10_g9593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9593.t1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40348" checksum="FAFEEF79814C1912" modified="2023-02-22" version="1">MERQRSCSERSISSAESWELIKNENEKELPASEAPENFDNSFAYDQPLFEHKISSDASFNPFLCSEFSLEDVLSVENSIWSVPSSHGGSTSDGSSADVEMEMCTAVPPPVRVAQHQKLIGNGIEPIGVMTVLFCAMTITAVLSVLENFVWTGFNLPLNNHTENGQKMVLNDSLREFYVNCRDDLVEFKNAYEASLEVVKRLRTDKIEQKKAIRQLQAEVVKLKTTARSADRTEQPLLPPTPPNTVRDENDGPHREEYVWESKRADARTEHRWRRLRDNYSTTISAFGPNFTKWLFERASLRQKLRKRNSNKQNFYRHENDEADGRGGGNDASGHWPTSVLACPNGRIGRKSCKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDM3</accession>
    <name>A0A914IDM3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cathepsin X</fullName>
            <ecNumber evidence="3">3.4.18.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.</text>
            <dbReference type="EC" id="3.4.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.18.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914IDM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8915.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8915.t2"/>
        <property type="gene ID" value="Gr19_v10_g8915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02698">
        <property type="entry name" value="Peptidase_C1A_CathepsinX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000158">
        <property type="entry name" value="CathePsin Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033157">
        <property type="entry name" value="CTSZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111439" description="cathepsin X" evidence="11">
        <location>
            <begin position="29"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="12">
        <location>
            <begin position="173"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8915.t2"/>
        </source>
    </evidence>
    <sequence length="419" mass="47673" checksum="9D34DEB904C368AC" modified="2023-02-22" version="1">MIRVPFGDFFFLTLLSLVLLSNKSPASCRRLSNLNLLNVVHTRDNKNSEIRELAKGNIGQSEKELKLVEDVEEPGDPVDAFWEWDRMVVGGGGELDFIPERMLRIGPSMVQKVPSAANRPLYSPFVFPNPHTSKHVAFPQKEMPPCLRPMDRPFRAHRTYPRSWEFPGFEASIPRHWDWRNVSGINYSSPNRNQHIPVYCGGCWVFGTLGSLQDRFNVARNNRWPMTQLSPQEIIACNGRGNCNGGTAEDVFVHAKIQGLVEEGCNNYKAVNEKCTPFTRCGSCWPDSCFAIQNYTRYYIKDYGKLSGRIQMMSEIHNRGPIACAISATEQFDKNYTGGIFQQLADSPSNHIVSVSGWGWDEESKTEFWIVRNSWGDAWGEMGWFRIVTSIYRGGRGDQYNLGIERECYFADPDVSNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEC5</accession>
    <name>A0A914IEC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD linked oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IEC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g944.t2">
        <property type="protein sequence ID" value="Gr19_v10_g944.t2"/>
        <property type="gene ID" value="Gr19_v10_g944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD linked oxidase N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g944.t2"/>
        </source>
    </evidence>
    <sequence length="497" mass="55334" checksum="74696DA472D67040" modified="2023-02-22" version="1">MQSYSRKSLLDILYFVPQTSELDRDYDIEGLFIFGGLCSNVHVGGHVQTGGYGVSIRAFGLFADYVTGLDMVTADGKALHVQPDSQNKTIRDLFYAVLGGSPGNFVHSSTAVLTHITIKPIQGKDHPNSVGYRATYLYTKQSLLDILHFVTQTAELDRGYNIMVTVLSGNKTFPGHAPLPSVISISAQWSNIGGQNQKVNDDVNGFFKHIEAAFEDTFAIPMKDQDMELTVHTPLSNMPLKYACPSMREFIYDRRLYLSDWNTAKLQKRLWSNGTADRLDEFLTARNKQPAPIDVSRFEIFSQLQNCGGSKSQFYSNSFRKNPVDGRDLVSYSWRNMTVGASFDAFYNTTEDPDAQQFVEQWQEETMDGARWAPAGTTPIFFGRRTATATWATCGTNITPRRNTNVSYASNARLTRLQVFTPNNFTVGVPKGKPDFASPAPVLLPEDNFPITIDLIRNSGAGAVDAYMLGWMQAKNDRASKLARRRGSGANRARGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEG6</accession>
    <name>A0A914IEG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g987.t1">
        <property type="protein sequence ID" value="Gr19_v10_g987.t1"/>
        <property type="gene ID" value="Gr19_v10_g987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036882610" evidence="2">
        <location>
            <begin position="22"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="133"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g987.t1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47541" checksum="1C6A4198AF35D425" modified="2023-02-22" version="1">MPKMSLSSALFVLLLTTAVKCPHPHFLLPQTPSPTLSGRSSSSEVQQADFAVSECESPGKKVRLSTATTSTMTAEIAREIGEVSSNAKSGENVPLFMGRKTVEVVSAADGLMYTEKVPDNPLVGSVQYNKAEQYFYDSLRVPTDLVGLLCGKDGNRRNKIAEQNRCTLRFPKKQKPGSQTEIELSSTENALHVQACREALEKALVDARQKAAPTHFISVPIFDAAFRAQFSEMVDRICADETLPEELRNKKMYMTPSKLHLTLSVFKLFTEEEIQRVRHFLDEQFRSKNIRDILEGTDGKLRIEFRSLQNLGNQPEQCRVLFAQPKAESLQCLANALDDALTQAGLVQKRRSDDVLLHMTVLNTKYLWKGWQTVDATQLLEKFGQLQFPPVDVEELHLCSMRGNANASDPNGYVSVHSVKFASTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEY8</accession>
    <name>A0A914IEY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEY8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9290.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9290.t1"/>
        <property type="gene ID" value="Gr19_v10_g9290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9290.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="38213" checksum="572F712E8AF5C7CE" modified="2023-02-22" version="1">MLNIDKRTLGLWEMKSKGLTGINKNYTEVEKQEIIAEFDKLKNEFKARYKGMPYENINEKIVQKLGVSLRTINLWKKQLGVSKPQKKHTDAEKVELLKKCCKIKKENPPLRKYEIAKMLNIDKTTLSLWERESKGIKPENRKKHAEAKKAEFMKQFYKIEEKNPKMNKEEIAQRQFGVSKKRKNHTDTEKVELLKNFNKIKKENPQLRTDEIAQMLNIHITTLNLWDKKYKIILKPDIKNFYSEVEKQGIVAEFDGLKNDFKTRANGMSYDMKKIDEKIAQKLGVSRRTIYYWKRQIGVSMDNGGPIDNVQRHVGFERSTSSAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IG67</accession>
    <name>A0A914IG67_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IG67"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9609.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9609.t2"/>
        <property type="gene ID" value="Gr19_v10_g9609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="134"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9609.t2"/>
        </source>
    </evidence>
    <sequence length="278" mass="31568" checksum="D534B96F584B88C4" modified="2023-02-22" version="1">MLSFIYVDDLSGLNGDNAIAILDRDELMISEEIAIWNAALCWADEKQNEKECSAENRRAMLGPALYKIRFPLMPKEAFSENIVSCGVLTDAELVSVYLHHCHPDRALSELYQLQFSTKRRAATKSPGDDPYKAKGNIVLKLEKVSEFAREDENSRRLGEAVYIRGLPWKILAVQRVLRRRSREKCLGFFVQCNGENTDPNWRCAGSATLRIVSQMEGKTDHTRVSGRHIFHSKDNDWGFAQFMTFKELMDPDNGWYDAKNDTVILSAEVTADKPTGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IHD0</accession>
    <name>A0A914IHD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IHD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9914.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9914.t1"/>
        <property type="gene ID" value="Gr19_v10_g9914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9914.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9227" checksum="8BDDE4D29EEA95E9" modified="2023-02-22" version="1">MCCSASIGITPCCAPQLLPIISPPMPLLPPPLPLIGAGCCPCCMPMCVPMCVRSSCGGMFGGGLFGGGGCPFGGWKQKRTVKRKRTIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPS8</accession>
    <name>A0A914GPS8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914GPS8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10043.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10043.t1"/>
        <property type="gene ID" value="Gr19_v10_g10043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10043.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12805" checksum="2A1F8221CD9376E3" modified="2023-02-22" version="1">MEEVWECDVKKELKRNKEMKKIFEGVPDEGPINPRDAYSGGRTMPFCLYAAASDNVEISMFDIISLYPFVNYYSPYPVGIPKIVQSPNYIVNWYEKYFIPIRRRFFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ56</accession>
    <name>A0A914GQ56_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH CENPB-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQ56"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10400.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10400.t1"/>
        <property type="gene ID" value="Gr19_v10_g10400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051839">
        <property type="entry name" value="RD_transcriptional_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33215">
        <property type="entry name" value="PROTEIN DISTAL ANTENNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33215:SF13">
        <property type="entry name" value="PROTEIN DISTAL ANTENNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="296"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10400.t1"/>
        </source>
    </evidence>
    <sequence length="485" mass="53145" checksum="5D25E77B1439420A" modified="2023-02-22" version="1">MDLFSIQSMLNSLYAPPLCSSSSSSPSNVSSASQNPQHLAHPSGLSAFEFYLHHQHLHRQCLPSSTSNFRNAFASPDVPCAGTEHHQFDPELLQKVVHHLGALVQHNQQPFVTTSDTQGTASSPLSALLLLLQQLRSLPNGQSAVSSDPTSILPLCSPPDFCPLLPADSANANKVTAAVSSNQRSSTFEHQQTSPATSCDFVSVSSGSSCSSSFESSLGESKTFSAGGTRNASGVATAHRLSYPREFKLLVLKSFWANGQNKYRTCKEFQITKSMLNGWLQKADRIRRSRPGSLKSGRSGRRPQFPKVEQQLFEMVQHHLSLGERASNKWIRKMARKLTATAESNGGEKEEEDGGGGRGIGEDGGGMCQFSERWLNNFKRRYGIQTAEGTVTASADEADGDEARRAEALFVGAISPPPHAPFSPQSLTDELWQDEEQWRSIAWEICATNDRLPIQAFYDRFPKVLQQTGKASDEMIRKFDQLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQR5</accession>
    <name>A0A914GQR5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase family 31 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQR5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10315.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10315.t1"/>
        <property type="gene ID" value="Gr19_v10_g10315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000039">
        <property type="entry name" value="Glucosidase, alpha neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000023">
        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF145">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="7">
        <location>
            <begin position="130"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="405"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="734"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10315.t1"/>
        </source>
    </evidence>
    <sequence length="964" mass="111351" checksum="F4A5E469DD4FC25C" modified="2023-02-22" version="1">MCCRTPYYVHSALHGHWAHKRASQMHQETADVICMAFAGGAAAKHFTGAWPGCERDEYVARSMARELVLATPRRRVLTEQHSPPTSIIRHRAKKDNPVYNVRVESVKANETAIEAILESSANRLSMVLALLDDDRLRLLIDEIKPIRQRFHPVIALDGEPKHRRLLAAELGVESASFVTGDGKKSTPAYKVLLNYRPFRVDVFTNSNTKEKELIVSINSRQLFKFEHFRPPANRKDGEDGEGFWEETFKGHTDTKPHGSSSIGLDVSFIGFKSIYGLPEHSDSFGLRSTNSYEPLRLYNLDVFEYDLHIGMALYGTIPFVLAHGKQRSVGALWLNAAETWVDVHSSTADQGVLAKIIDQFRSSKEVPQVDVHFVSETGVLDLFLMLGPRPKDVFRQNAALTGVMPLPPLFAIAYHQCRWNYNDQEDLLAVNRAFDEHDIPVDVLWLDIEHTDGKKYFTWDPVKFPNSLEMAKEIESKGRRVVTVIDPHIKKDDSYNIYTEARDKGFFVKKADGQGDYEGHCWPGASMWLDYLNAEVRNFWAEKFALDQYKGTTENMFTWNDMNEPSVFSGPEITMHKDALHAGGWEHRDVHNIYGFMQTMASVDGLRRRSGDRLRPFLLSRSFFVGSQRFVTIWTGDNVAEWTHLKQSIPMLLSVAISDVGGFFKNPDAQLLVRWYQAGAFQPFFRAHAHIDTKRREPWLFADREKAAMRDAIRKRYAFLPYWYTLFYEHTKTGVPPMRPVWAEFPEDEAAFDEEREWLVGPGLLVRPVVEPDVEQVSLYLPGKAQTWFDWDTHRIYLSPGAIYTETPLEKIPVYQRGGTIIPLRERPRRSSKMQRNDPITLYIAAEADREFANGTLYLDDGETHNYRDHNEYLYWGFTYKKVNDHTYSIIAKSLDNRGTLDPDVWVERIVIRGLRYYPRNVHMYYEDYTPDDLEFTHDRENRLLTIRKPGAYVSREWRIDIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQY4</accession>
    <name>A0A914GQY4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQY4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10488.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10488.t2"/>
        <property type="gene ID" value="Gr19_v10_g10488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10488.t2"/>
        </source>
    </evidence>
    <sequence length="273" mass="29955" checksum="7FEB8054D7980CD7" modified="2023-02-22" version="1">MWESVIWPIAMDNGGEKNGTRRQKPRSSIPLIGRRCSCVIEMSDGKAAETRGGGGGGGNARGWEDKIDSLSNDHSLAVVEFDPNDRRYRCCCGQSHATTGVRIIAGGLCVTVLLEFWQLCWHFLPSLGTSNTFPAPTTGSVVQLLFGLFTVSSCIGLSAVFVIFLALFYVVLDNDVETIKAFVNSHGPVKAATTDNAELVYMGWTLCLSCLCLLAIQLWLISIVLSSIRSRKDAYACRRHNQEEQQRTGDDELLRKVANELMMPCPLPAHTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS35</accession>
    <name>A0A914GS35_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS35"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10882.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10882.t1"/>
        <property type="gene ID" value="Gr19_v10_g10882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10882.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33629" checksum="C5020773CA3AF77F" modified="2023-02-22" version="1">MYKQMRESESEESGKYSHPINKGGNKMAGLQSQQPSRFKSDNDQLKPDQLLLKLDQTHPHSGWTQLANRIEEAVVKNLEPPAADKENANIGINKPCSSAENSPQNPRMKFKTIAKGLSLMSRVRAADTALEREQHAFFTKYGISTSDGVQQEEYASDLSNNVRVFDWNGISINEFFRQKFVVDPYTDYYYRWMGVVTLAYCYNLLLIVYRCVFIDKESASLTCLIVFIFFDIIFDIVYVIDSFVRARTGYLDQGLLVRDVAKIKRRYMKNKMRWVDLINNKSMLSIQPPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSR1</accession>
    <name>A0A914GSR1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSR1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10042.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10042.t1"/>
        <property type="gene ID" value="Gr19_v10_g10042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10042.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15279" checksum="E34098C89603A36D" modified="2023-02-22" version="1">MVRFNPLVEVKETKPEEDVPYDGLLKVKVVPPKNLMYPPLPLHLDDMLRFINCGVCAKKAKKEFVRAGDVEKCAHSDEERALLGTFTSIELHNALELGYKVIRFYRAYHFEEFDSQLFKGSKTMRAETEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW60</accession>
    <name>A0A914GW60_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW60"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10958.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10958.t1"/>
        <property type="gene ID" value="Gr19_v10_g10958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10958.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24981" checksum="28CEA3FEBC2469E3" modified="2023-02-22" version="1">MDLVKKYHDGQNTEITSVKDLYDKLKEKNVFGKSITTLTRYVTKIQKEKEAIEAKKYLAGAHQNLLKRQHEVALQSMPGLHATAYLPNQSQSTAWTGASNQSSQFQGQQPNSSRFYNPTQQQQTSNFGTNQSQSTRRTNTINFSHPSSQFQGQQPNSSRFYNPTQQQQTSNFGTNQSQSTRRTNAINFEGPSRSNNADKELDLTLSLGGNSKKNKGKSKYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWB2</accession>
    <name>A0A914GWB2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat and sterile alpha motif domain-containing protein 1B</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWB2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11790.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11790.t1"/>
        <property type="gene ID" value="Gr19_v10_g11790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF16">
        <property type="entry name" value="CASKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="935"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="1066"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="630"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="733"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="804"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11790.t1"/>
        </source>
    </evidence>
    <sequence length="1195" mass="129503" checksum="CF979E9B2297B7D0" modified="2023-02-22" version="1">MGRQCAQNIQELFEDCRRGQTHAVQLWIAQKSKKHKSPLNFLRSGNAFGGGSGAGNGVGWLAGLREPSTSHTLLHLAALHGHRELTRLLMQRDVQLATARDRKGCLPLHLAAWNGHEEIIEALLEVEPATVNAVNNARESALHLATLNGHANAARLLLRRHADARLRNARLETALDIAVRTDKANLCRLLMLNCTELNLMSASDCCASAPLSMAALKQPSPPYPLHSAARVGHTNCVEALLEHGFDPNYLGPEGTAMHVAARLGQCATLQALLNWGASIDIRDSSGQTVSEWLETRLSSSTRDADEGTEQRLRECQKLLEETERRRRTQPERYGSSRGPGDIWKSAVPEPKRKQYNNGTLKNGARIPVPPPPLASGRPHSQPVSATSPPPRSMSSPLKGTFSPTSCTYQPLPDENRLKKVPTNSLPPYQNVPKTPLVYDNAPLSTDRQKKWAHNCANGCALPDNFGDFADTVAVSKLAPQCQDLSPCSTLERSPQSIRGGYGAFFCDTVAAHQLPDYGGAPLAAHEELLSASATPLPTTPERSVPQHLSSDEDKSPSSDAIVSLEMPSCSSSIVTLAPDSSPSSCSLPMVSHLSPSSSVSPERAVTFGGEFHHCASPESDERLRSSINSPTANAQQQTFTTQNSNRAHGTAEVPSGSSGERSFSSPPSSSARPRVRQLVHWMEETNKATLFGQVDGAGVQAVHGAEDVSEFHNGRQHQNHFAPTGSGLLEPRTGCQHQMHSSGVEHDPKTSSGSKHIGQPGAQNVQQAEGVAATVHALSSDRKQSMVDHAAQWKEIDELLNSLQRDSQQPEEQSHSLIKNSSKNSVTSMASSSPANSSSGGGGNGTACAYQPIVRWLRIHVGLSRDQHQQQQQLNSSAQALGELFHRHGFDTVRFMKGSLNTALMDELGVPRRVQLQICRLLNDKSVPEHIRSAEQFEFVSDWLDSLDLLDHLGPFAKANLTSTTDVIAAKLSRGDLEKMDITQLGHIARITRSLDLAAQQRKKRQRLPTTNLNASGSTSPSASGNGSVRETSSQSSSNKSGQNPSRAVTQSPVVDMGELRTRLTGGGARFSAHYLGSAEISNVEGTEDCRRAMQSAKTRVRRTADVPWVVLEVSVSGINIRDLNEKALHCHPIGNIQVVCQDEVDLNCFAYIFQDGERHFCHVFCVLTATIAKEIIVTLGETFNLAYNIALQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWE8</accession>
    <name>A0A914GWE8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Torsin-1A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWE8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11956.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11956.t1"/>
        <property type="gene ID" value="Gr19_v10_g11956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="2">
        <location>
            <begin position="235"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11956.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35323" checksum="52EE019ADA21D976" modified="2023-02-22" version="1">MRGIRFLLLSLLFYSPYFFISCGAELVSLTVGVSAFSALGLFIGDFGGLYTLTKCKFYECCDRPWINRDVALRLEPDVEERLYGQHIAQNTVIKALKAHLAKSLGYVLSRLDGLGQELSGEDDRRSHLQESNAKSIRPPIRGHPSLPKCGGNGQIQRAASHLDSNQFVEFNGGANSIAQRALEYYNRGKSREEIAFREMEEIIQISAYNEGEGGLKSSRLINKHLIDYFVPFLPLERKHIVMCFKDYLRSLNVNYTPEQLERLVDSISYFPRETPIYASAGCKQVVQRTDFMLDDLIRESRLAINNYSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWG6</accession>
    <name>A0A914GWG6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWG6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11035.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11035.t1"/>
        <property type="gene ID" value="Gr19_v10_g11035"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6782.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6782.t1"/>
        <property type="gene ID" value="Gr19_v10_g6782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275805" evidence="2">
        <location>
            <begin position="23"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11035.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6782.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="33645" checksum="C7798F96B22CE7C5" modified="2023-02-22" version="1">MKLNVVVLIVFAVLALSAICNAKKDREKKKDADTKSQGEASNSNLLPLHYQTNQHGDNSYWDNTHHTDGRLIQPRHESSEPTPDDSWDALQAALAAQPARMPPTNPPNQQATTASVGHSAQHPVNVSDSEASYSWPTNPPNQQATASVGHSAQHPVNVSDSEASYSWPTNPPNQQATASVGHSAQHPVNVSDSAESYSWPTNPPNQQATASVGHSAQNPVNVSDSEASYSWPTNPPNQQATASVGHSAQHPVNVSDSAESYSWPTNPPNQQATASVGHSAQNPVNVSDSEASYAWFYDRTDSSSDSSTKSTGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXQ5</accession>
    <name>A0A914GXQ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12120.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12120.t1"/>
        <property type="gene ID" value="Gr19_v10_g12120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12120.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10893" checksum="24E347D80A90F2F3" modified="2023-02-22" version="1">MTFRQRTIDNDISTIQPSALDISRSLASSNAKLLAEPLIIKDMANADHHLWNDATTIVCQLYDAERGFAKAAKQIREPEECYNFIKIYLTEAFQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYN9</accession>
    <name>A0A914GYN9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYN9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12555.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12555.t1"/>
        <property type="gene ID" value="Gr19_v10_g12555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12555.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25275" checksum="3985F0DB5554A2BC" modified="2023-02-22" version="1">MPFRGHKQIHTHSFIFTSVHFMMISSFSSSSNSYFSPPFPKPFVRPRPPVRRLPNELLNELAKFASYDVLEQSCTANARLLAVFRPVLQQKDTKLCSLYFDDVRSLSVRLKQWTARSDSLRKFVVLRASVDSKWCEDAAQAKRDLWTVNRARVTSRGVIADLRDLRALLDEFASTLTKISEGRLLKHASMSRDWPRSFNLGASSSARFRANRSHLIVAALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYU3</accession>
    <name>A0A914GYU3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYU3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11657.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11657.t1"/>
        <property type="gene ID" value="Gr19_v10_g11657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036972417" description="Fucosyltransferase" evidence="13">
        <location>
            <begin position="31"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="14">
        <location>
            <begin position="172"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11657.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="42459" checksum="4D8B59F65D993CEF" modified="2023-02-22" version="1">MDYNERWQLRRMPWHCLLFHLLNISANCFAAESEANEPIILGWNNFFNQGNIIQTIAPEEQVRKCKRKCKYSQDKKIAENASVIVFHQTARGVLPGGRRSDQLYVMFDLESPSNSHPQHPFPDFFNLSMTYRAEDEHNLLAPYGGLHRIDRSKSEVLKDIWTWEEVLTKVGRKDKMALQIASNCASHSGREAYTNELGKYMEITGYGRCFGRDCDKMCYDAQIDRHFFYLAFENSVCHNYVTEKFWNALRHLTVPVVLSRKALKGLDIPPEAFVAADDFGTVEEMAKFLLELRFDQTRYLRFFNWTQFYRRQSDIDPPARAICRLCELAHKRLAPGSKCSLSQNDECKNLNKCGDGGLQQQQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0F5</accession>
    <name>A0A914H0F5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0F5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12901.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12901.t1"/>
        <property type="gene ID" value="Gr19_v10_g12901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12901.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18319" checksum="B5F8FC41884BF179" modified="2023-02-22" version="1">MFPRQNQPLNHLIVNGCCLSLLNEQSYHFSPYTTYLEERIKYGAACFKSVAALVSNFKPMEMTQLELCAFLGIQFWNCIEKFVPLSAEQSARRNEFFVELHAMVAQRVGMNMAQIAIRFGQLLKLLLDTSEPTGDVDGKSASRSRTSLQQMQVILCKELMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0U5</accession>
    <name>A0A914H0U5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0U5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1290.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1290.t1"/>
        <property type="gene ID" value="Gr19_v10_g1290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF82">
        <property type="entry name" value="NEURONAL IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN RIG-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036987461" evidence="5">
        <location>
            <begin position="21"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="247"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1290.t1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64964" checksum="E620FBDCD9270D98" modified="2023-02-22" version="1">MVHFFFHLLLLLFALPSIDATKSVLSVQPKGVGLDQSFYLVNSGSRLELQCELNTNATNVHGALDFAKDGLKWMRGLLPVEAKWLSMYTESDSDPNGNWVRNTLVIQQVDDNSKGDYRCVYFGGVERHVHIHLIEKINWRLKSDKPGGQIGAPLTIDCGAYGVPNENIKIMDQSGSAIEESAILIALGEKLYVTGHEMTIEKLKRSHRGMKIRCFAIRTEMIGGEQDAVPTIHTDERNLTVDVWEPPHFAGLEHGGHFYVKLGSPAVLRWRVNSSNPPVLNFTIKRDGKIIGNDGRREIKIDEKENMASLMINKVLDEDYDQYTCIAHNGKLRGEQNAFLDKPNPPKQPKVWAEQVTNNSVRWHVEERTEAGLLPVIYFQITYRPLRRRIQQQQKPKQNLDSSEENAMASDNGDDSGDYWQQQRLRGDAVVRQNGGDKVNASGDGEWKVLEKNNTPSLSVIRHKNPENVFDIVGLDPFTEYEFTFEAFNQAGNSDPVTIKQETVDYWELSADDRHSQQQRGQKDDSAISSGSISVYVGFGLSGLLVLSFIAFVVFFVDCHDENVPTVDKRRVDAPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0V3</accession>
    <name>A0A914H0V3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydroxysteroid dehydrogenase-like protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0V3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13135.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13135.t2"/>
        <property type="gene ID" value="Gr19_v10_g13135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09762">
        <property type="entry name" value="HSDL2_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000301">
        <property type="entry name" value="Hydroxysteroid dehydrogenase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006133">
        <property type="entry name" value="PRK08278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF3">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13135.t2"/>
        </source>
    </evidence>
    <sequence length="301" mass="33462" checksum="C7F2EA023B82868E" modified="2023-02-22" version="1">MLNTGKFLGKTFVITGASRGIGKEIALKFAKDGANIVICAKTAQENKKLPGTIYSAAEEIEKAGGKALPLQVDVREEQQVQEAVEKAVKTFGAIDFLVNNASAISLTSTLDTPMKRYDLMHSVNVRGTFLMSQKCVPYLRQSKNPHILNLSPPLLMEKQWFSHHVAYTMSKYGMSMCVLGMHEEFRKDGIAVNALWPRTTIWTAATEMLTSGKGKQMSRKPEIVADAAYVILSKNSRDYTGNFALDEDVLREIGVKDFSQYANDPKSKLMPDAFVPGESHRTLAGFLKEMAMDDWLKRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0X4</accession>
    <name>A0A914H0X4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0X4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12223.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12223.t1"/>
        <property type="gene ID" value="Gr19_v10_g12223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF6">
        <property type="entry name" value="GH01133P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12223.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29935" checksum="A128940A9463AEEE" modified="2023-02-22" version="1">MIDLIVHTPGGNVQCVSGVNESTTCSQIVYALAHAIRQKGSFALVGRTDGASKREYRFIANERPYDFVQKSAQHGARIEFELLRLDDEERSASLEYEGDVEGNASANSSTTTLNEFFNCQQKQAVQNRPPPPDYNELMAERCNSLRRGISSSKKPCPLTFLNIPNFSFQDLCARTFSRPDLEALVEVQEKTLTAQKGELVRVELTLLDSDERALVQLRKQHNNLQTVLNSMRNANWSDRIGTESATAERLHTAIAAMRTAQAEKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1S5</accession>
    <name>A0A914H1S5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1S5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12872.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12872.t1"/>
        <property type="gene ID" value="Gr19_v10_g12872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12872.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33874" checksum="330320BB86F36A78" modified="2023-02-22" version="1">MDLGWVNGCVSVHQACANMSRMLRANRRRVPIYRDDEHFFGNDGLGSAPNQFPKVLPDDFNAFVEGKHAALALYELFSSNPGTILVCIGPLTNVALALKLNPTFACLPEQMVILGGNVYGMGNVQSYSTAECNFNCDPEAAQIVLKEMQCPITIVPWETFMAKSDQTHDIDFHSHLALDVPLAKFFATVTSVGRARLEANNRQFAYCDEVAVGIAIAEETIIRESKMLRASVELHGELTRGQIAVDWTSVLYQMDKGEHPKLCKQRRPIKFVLDYDVHHLDRMIIEAIENSASNLDSAHINGYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1U7</accession>
    <name>A0A914H1U7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1U7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1313.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1313.t2"/>
        <property type="gene ID" value="Gr19_v10_g1313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="89"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="281"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1313.t2"/>
        </source>
    </evidence>
    <sequence length="580" mass="64374" checksum="82ECE90E56E91FB5" modified="2023-02-22" version="1">MSLFELCRPDAFPPLGSGGRFILLNNNRINKARHGTGMALSVKERQFFGMEGLMPQGIMSQEQQARRAIEQLRAQPDDMARFIHLDALRERNEKLFFKVLQENLDELLPVVYTPNVGSACINFEFKYPKALFIDIVSHKSVKAINRVLGNWKDQDVRAIVVTDGERILGLGDLGVGGIEIAVSKLTLYVALGRVQPQWCLPVLLDVGTDNANLLNDCNYMGLRQPRLRGERYDQFVDNFMEACRRKFGPHILIQFEDFGKSNAARLLRRYQNNYCTFNDDIQGTGSVTIAGLLAAAKITKQKISESKFLFHGAGMAAIGISELLVSQMQFEGLSRQNACERIFLFKSDGLVTKSRQNLMDEQKAFAKEMAEMKELADVVKAVQPSAIIGVSTASGAFTDAIIKEMAAFNDRPVIFALSNPTSKSECTAEAAYFGTNGRALFASGSPFPPVKISDERTLMPGHCNNSYIFPGVALGVILFKIAPKLAESVTDAEISSGALYPSLSKIPEVSIQIAVAIAEECFKDGTAQLCPEPSEKELFVRSQLYNTDYEDILPKMHSTTPKAQRKFDEFEFDPKVEIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H219</accession>
    <name>A0A914H219_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">valine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914H219"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12506.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12506.t1"/>
        <property type="gene ID" value="Gr19_v10_g12506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="95"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="809"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12506.t1"/>
        </source>
    </evidence>
    <sequence length="964" mass="109448" checksum="62FC9F473BE86C69" modified="2023-02-22" version="1">MSSSETAGAKPKTERELAKERAKAEKLAKFAEKQRKAEAQKTANLLKSEDNKKAKGKGTATANVMYHWQTKAGEKKDVSGDMPAAYSPRYVEAAWYEWWERQGFFRPEYGQRDCNKSNPSGKFVIVIPPPNVTGTLHLGHALSTAVEDTIARWHRMLNRTVLFVPGCDHAGIATQVVVEKKLKRERGLTRHDLGRADFVKEVWNWKNEKGHIIYDQLKKMGAGVDWDRAVFMMDPKIMRAVTEAFVRMHDKGVIYRSKRLVSWSCALSSAISEIEVEKHEIAGRTLLTVPGHAEKVEVGVLVLFAYPLEEEEEEEKAFGSSTNGSATAADGCCRREIVVATTRLETMLGDMAIAVHPEDTRYKHLIGKHCRHPFFPARRLPIVADAAVLPEFGTGAVKITPAHDQTDYEIGQRHGLPLLNIFSDDGCCLPCCGPPFAGMRRFDARRAVRQRLEELGLYRDTKDNPMQLRICSRSKDIIEPIIKSQWYVRTSQMAQRAKEAVANGQLRLIPENHVNTWNVWMNDLRDWCISRQLWWGHQIPAYFVTVTGDHQPPSQSDVKPDQNDDGNDDEFYWVSGRTEAEARAKAAKRFKVPEEAITLKRDDDVLDTWFSAGMWPFSVMGWPEKTGDMRNFFPGNLLETGHDILFFWVARMVFMSQELCDGQLPFREVFLHAMVRDAHGRKMSKSLGNVIDPLDVIHGITLEQLNKKLEDGNLDPKEFETAKQGQARDYPQGIPECGTDALRFALMAYTTQGRDINLDVLRVQGYRFFCNKLWQGTRFVLSRLGTEFCPRDIFELNRLFDGMALSLADRWILSRLSHCVAECDAGFCAYNFRQLTSAIHHFWIHEFCDIYLESVKGLFVVGTQNQLHQKGGDGTDSTTTAANADAARHVLHLAVDCTLRLLAPIMPFIAEELWQRLPARPSWAVSVCIVHYPQPAEFSYHDKEAEADYELLRESVIVKAKLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2A6</accession>
    <name>A0A914H2A6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM200 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2A6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13222.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13222.t1"/>
        <property type="gene ID" value="Gr19_v10_g13222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018787">
        <property type="entry name" value="DUF2371_TMEM200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815">
        <property type="entry name" value="AGAP005329-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 200C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10177">
        <property type="entry name" value="DUF2371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13222.t1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45431" checksum="D81E8B740E0AC9A9" modified="2023-02-22" version="1">MLAARGVSLGLGGRINLSELNHLPKDKMILNRLKREHLAEQRAQQTRRLVVRKHVDSKTLWTACANVIIGVVVIFVGLIMTVLGYFDSANAPLPAAGQQKPFSDRYGDFDWLRYAMKSMQYIGPVFCGIGMFLMIIACVITLEARDRHAQIIQEESTELRRSRRYTSQQRKGELSEVGRPETGGQLRENGLKVTCARRHTHSAGDNPKRRKDAQRHQQQEMLSTADGEGSAANRQKTTLATSPPRPQKCHSTTNRPNIPPFFHGLSTISDASSTDPLNEYAFEEAPKRKKAARRVFDSTSDVRETEEETEFGEDGAVTGEQHKQTETAPRRKSTSAVQTVNKVRSSRRAAPLVRVESVVELSLSISGSPRWSKNDGDRSWGIFARLQNMSMELPASALKIGFLASFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2J2</accession>
    <name>A0A914H2J2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="18">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCE family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2J2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13548.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13548.t1"/>
        <property type="gene ID" value="Gr19_v10_g13548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000016">
        <property type="entry name" value="Tubulin-folding cofactor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="21">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="22">
        <location>
            <begin position="193"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="20">
        <location>
            <begin position="503"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13548.t1"/>
        </source>
    </evidence>
    <sequence length="1016" mass="111093" checksum="D18965B2322619EE" modified="2023-02-22" version="1">MCDRSSSSERNFVRSACPAASSSLTSSSSDHSPSAVNNNLPGFPVGVHSLPIAIGICAVCGDRADGHHYGVLSCRGCNAFFRRAVTFNLQFHCRREGHCDINKNARCACRACRLQKCQSVGMDRSAVQVRREMKDVLALGDAQQRRAGNSTEMLCLSPQQSVPPQFSTNSPVLGSARTLDLLPVRSRLLGSVTTVSSPLAMHSLDRLIEWYFCQRYRRQTMLCQKADEILRLIGGGGQAMTGGNSAAIPSMECPRVATVDDICQVHRVETVLMFEWVVQLEEFALIDPADKIRLLRAFAPRYLLLDFLLHSLECHSVDRLLLPNGAALVGQLNHNNHNPFAYIGHIDGGGGGGVHDSDRTMEMLSMDGEAMVRTLLIPLADAGVTFGELMALRLLLFWDCSVPLECVGSRDLVRQAAERTRSELAGWLEQYSVRGEGKVDTLLAMTPTLCAFAAKFASICGTIGEFNIMPGLQFMADLLDEGTVELNQRVVLNGSKGVVRYLGHVDGTSGEWAGIDWDDTSRGKHDGSLEDGRRYFTASSPSSASFVREHCLHTGVELFGAIQAKYAPVAADEDGDDDEVVEQCDVAATTAECTRGGGKGRWQLVNMDKIRRKQRDVFRLRCIVLSWSNVSHFDASKVGNRTFNECVELDLTETLVGKWTQICQILTNFSALRVFHLSGNRIEPLGLDTGEEAAAAFEQIKRELAACRITHLSMNKCRLDEQTSALLTALFTCLEEIYLADNGLAHYAPVGDCARLRVVDLQHNAFGGGDGRLPAISRLPSLEYLNLSSCGLSRLNLDDDDGGFCALKTLILQGNPICRWEAVDELARLPVLAKLILRGAPLPGARGVDSREMIIAKLPQILDLDRCDVSPVARRSAELLFLSRFGVEPIAPEHSATLARLAAIYDMQNDMQNGLHQQCPSSGAAVPPAATASTIYSKRVRLEHAGRSKERSLSLALPIHKIVGLGARLLGFDPDALKGVELRRADPAYPAELLCRTMDNLLRQFDIDDGDVLVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2Y4</accession>
    <name>A0A914H2Y4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914H2Y4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13659.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13659.t1"/>
        <property type="gene ID" value="Gr19_v10_g13659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038173344" description="Metalloendopeptidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="413"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="624"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="10">
        <location>
            <begin position="682"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="10">
        <location>
            <begin position="727"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="10">
        <location>
            <begin position="772"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="10">
        <location>
            <begin position="817"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="10">
        <location>
            <begin position="862"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="10">
        <location>
            <begin position="907"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13659.t1"/>
        </source>
    </evidence>
    <sequence length="950" mass="104519" checksum="C71B9071CADA475B" modified="2023-02-22" version="1">MATNALLFLSACLMLLPPLLLANGGGLLGLLLKEDNGGNAVNGRNRLHGAGGGSELLAELVSAWGRGGGSEAKNGRKERHGHGRGAGHGHKNEDKKNGGTEADGNGTVKKGGHEQGMKQQHGSLLGAVVGGQLGGKPVGDKLAKNGFGEQLIDGVPLRFYAPDPNSDIPPHVLRRVMRFCSKHPTHDKCKNHPDWIIDEDVLPALPGLTDKLLEEFPTKLHFTIPARRQLRLEPLLKDVPDELVKALPEAKKLDAKSKQILVNRCAGGLCKKQKPEYLNQRASLAELESVTLKSLFPDIPIESIDLAIEVRQRRVYEVKKALLKQAGLEEYIEPADNGVFQNDILLTEAQANAMLTQIEHAGENVRVIPDGPPELFPIEVAPSTDTGGAFIDGGGRPALFPPGRSMRTKRAGNSLFLEKSPDEKWSIEQPIEFVLDNSFGASEQWTIRAALRQMQSKTCIRFVEVTTSPSGAYMKYINNYGANTCGLSYVGIVLPVNTIKLNFACPNMLGVTMHETMHALGLDHEHQRPDRDDFINILWDNIEPQHTEMFTPTLATKYTSYGIHYDFSSLMHYSYRATARQYWLKTMTAKVNPEVNDEKMGIRDALAQSDVNVLNRMYCTASDCVDKKVDCGTLAATKDKCYNDGTRDAWMVENCRKSCSFCKPTIGAAAQVSSSEEDLEEDLDEDLDGLQDMFPNIHKEVIREVLEAKKGDRELAVNTLIEMGKPESEANLDELQEMFPSFSKEVIRDVLAATAGNKASTVRALNEMAKPRPAPGLNELRKMFPNILEEVIRDVLEANGGNRELAVDALIEKAKPRPAPGLNELRKMFPNILEEVIRDVLEANGGNRELAVSALTDMTKPRPAPGLNELRKMFPNILEEVIRDVLEANGGNRELAVDALIEKAKPRPAPGLNELRKMFPSLSKELIRDVLEANGGNRELAVSALIKMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3I8</accession>
    <name>A0A914H3I8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914H3I8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13812.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13812.t1"/>
        <property type="gene ID" value="Gr19_v10_g13812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="174"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13812.t1"/>
        </source>
    </evidence>
    <sequence length="497" mass="56630" checksum="7FE0B6937694CE2E" modified="2023-02-22" version="1">MLSRLIAARRDANGDERVIASTQTNSPSLSDDDEPDLSAAAVEYVFQANIDQLPVVADEIAACTAKDETLSQVLQHCRTHWPKEAASSPLSAFFVHRSKLSEVQGCLLFGDRVIIPAELRQRILKALHFTHPGMVRMKSLARQFVYWPRITTDIERWVRNCPDCASAAKAPPKVPLRPWPSAGAVYERLHMDFAGPCSDGFKYLVVVDAHSKWPEVIKMNATSAPFLITQLTWLFSRYGFPKEIVSDNGPPFKSSELSHFCRSRGIKQTFSPPFHPQSNGQAERFVDILKRQLKKCARDDKEWVQNSLLAYRSTPSEVLRGRTPAELFLGRPIRTVLSLVKPGSGVQKGGKVHQDRDRMCRQFDRRHGTQQRPFNIGDRVLFLNYRQNKRMWLPGEVVEGSGVVWKVWAQDLRATVTRHSNQMRLSQPIPYQERPEQQQIPRTPSPERQPSPIQEEPPQHQATPRKVRFEANLPQDTNRRNSRRSDVRHVNGSRCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H430</accession>
    <name>A0A914H430_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H430"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13449.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13449.t1"/>
        <property type="gene ID" value="Gr19_v10_g13449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46397:SF5">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46397">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13449.t1"/>
        </source>
    </evidence>
    <sequence length="481" mass="54116" checksum="9C3149046C24667B" modified="2023-02-22" version="1">MISSDFECRVCYAYATGIHFGAQSCQACCAFFRRSVVLNRNYLCHRQAKTGTNCAIMYTEKVLCRFCRLAKCLAIGMDKKAVQVPERGGQSDPKRGRAYFTKSGLQRNKRFASGALGLHGADGFTAAQIHSETVAPTSDDVSDSPPPPSTSNSLPSAHSSVSIPSNGLSPSSSSSSSTSLHILHDHLTSSPQNNFHRPPPKPSPVGPLRPCTIPSWDILGLFIEEEMRIAERRRILFCERPVASLLGRSKSCPFSREDIRPLSFQEFRRSIRTHILLVYEWLRVWPAYGQLDIEDQITLLRKCVLYHTILDPCFLTTQIGDLDKFVLPNGGYVSTKRDEGWEDEPEISRDTKMSIYWPLLVPLMCNIVAPMLLMCLDFDEFVALKAFVSFQMTLPDISSTGRVMIGAELSSLSQSLHKYYVTKSTTLKDEFARAERFGNLLLLLSPIFETANIFVESHHIIQFFDLWEMDSLMLQFLKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H449</accession>
    <name>A0A914H449_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H449"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13816.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13816.t1"/>
        <property type="gene ID" value="Gr19_v10_g13816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13816.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37122" checksum="C07D07A2BEF51584" modified="2023-02-22" version="1">MSSAKIPENLFYKETQQQNGGGHSPALIVMAVLLNCVGIPGFLMNFSVVYVTIKNRTLHGSANFLLALSSLFEMGHQAGHLVFLWLALSGQNFISYAMCFRLMAFSVFCLGGMYVIMFCTGVDRFLCVLTPKFHGRLNLSIYLAFHCAFCLASCAYLTLSLGHCAELYPSYPVTGYFGDLFVGICSTLPEPALLLNLGTIFLYLIVGMYIWRQPTSSQFRIFRSLAVIIVVNIGGYIFESIMRLIVLQNLHLSNQMFWYITSYNGIILNISSACNAIVLFCLSKDYRAAYRKEFEFLSRILRLGSQNPSIVVTGAAVSVKPSLIVRTAPVLASTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4L6</accession>
    <name>A0A914H4L6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4L6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13603.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13603.t1"/>
        <property type="gene ID" value="Gr19_v10_g13603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037342725" evidence="2">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13603.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15744" checksum="632950708BD9951A" modified="2023-02-22" version="1">MWPIWVPFLLLCLLPLPLIFAQQQQQPFVAYPRAPSWTPQQMDSRSGGGGAAVGGKMRLRMYSHNNDHNNNIVEQQLQPVEGQQQQRHSLKGTTSAEQSVETQGILDHLDYLIRGAVERPRQPDPQPPHGGGGTRGNDVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H688</accession>
    <name>A0A914H688_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 107</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H688"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13613.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13613.t1"/>
        <property type="gene ID" value="Gr19_v10_g13613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029248">
        <property type="entry name" value="TMEM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14995">
        <property type="entry name" value="TMEM107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="4">
        <location>
            <begin position="331"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13613.t1"/>
        </source>
    </evidence>
    <sequence length="422" mass="46578" checksum="42A3CA1A63704F71" modified="2023-02-22" version="1">MDLDTNCLLTAVAQSCIAFTTFFNRNDHIVASLAPSTELTRNSQKMLYGDTDASLCIVLALSLAFLASECVLHLSIVQSPQLLQMYCLSAHTVACLCLLKFIVDAHPVHHFWWLFSLTNCPITKELAELTTHAERFVGLEGGGMDQACECLARRGEALRIDFRPLGWRAVRLPDNALFAVLHSNTEMNKTASAFYNQRVVECRIAAQVISKRSGCVPSGAEWHSVRTLKQVAALLGKDDQPEQMLSIVDQHLAKPGQQQQQLVAHSREEICAILNCTDAELAKWSLNANTQNMHEFWLTKRARHVYAEAARVLEFESVCREERQHGNDETLGKLAELMNASHLSCAQLFECSCPELDETVANCLSAGCIGARLTGAGWGGCAVALVAKAKRAQVEASGLNVLFWSEPCEGIEAFPFRRQADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6Z1</accession>
    <name>A0A914H6Z1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6Z1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13797.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13797.t1"/>
        <property type="gene ID" value="Gr19_v10_g13797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13797.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32996" checksum="16872965BA090800" modified="2023-02-22" version="1">MSTKSIRLPDDCWLDILSQLCRPFVASQFSLVSRRFATLADSRLWTKRQKLPPLFVLCDRLGWVNGEQFVEKPMPICAPPKNLQLSSITMFICSCMNNALDFLLCLRHHKLNAFDFANIRMLKVPSLECQLLSDADFPQLLFWLHYCAPNDQQAVANKKQLHLFCDHLPGIQLVEAFIRLLIQVFSRSIDSCPYTIQFVLSNYDPTAASAFNNSLLFASVHYNFETGESLKLFTQLSLTDGEHGRGQQTIVMERTMIEKLSIDAKACEEKNELISAGRQKEECILIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7X6</accession>
    <name>A0A914H7X6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7X6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14051.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14051.t1"/>
        <property type="gene ID" value="Gr19_v10_g14051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14051.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11437" checksum="5C0DF3A2DEFA8CC6" modified="2023-02-22" version="1">MIDQYFFYLAKMAVVFFILMISSATLEAQRNENDKFFDLMTAIGDHFGGEFNEAEKALELNLNGANSFLVELHKFATREIVKKNENGKFECKEMGIKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H821</accession>
    <name>A0A914H821_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H821"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14673.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14673.t1"/>
        <property type="gene ID" value="Gr19_v10_g14673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14673.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7418" checksum="8FDA47DD8B7A0201" modified="2023-02-22" version="1">MSKPSTLQAVQNPVLCVCAIVVLAFRQSIVPFYNPLNNTNQPTKPNIFEPTRAGVLQLLLLLLLTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H857</accession>
    <name>A0A914H857_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H857"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14122.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14122.t1"/>
        <property type="gene ID" value="Gr19_v10_g14122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF61">
        <property type="entry name" value="PEROXIDASE MLT-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14122.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9290" checksum="D6BEA1B7A299D62E" modified="2023-02-22" version="1">MTSICTLVEWRSRAGDRFYFENPNIFSPAQLTEFKKTSLSRLLCDNGDRITKVPSTAFLLPFAGGGVSACAELSQLDLNKWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8T2</accession>
    <name>A0A914H8T2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8T2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14813.t3">
        <property type="protein sequence ID" value="Gr19_v10_g14813.t3"/>
        <property type="gene ID" value="Gr19_v10_g14813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14813.t3"/>
        </source>
    </evidence>
    <sequence length="640" mass="75481" checksum="FEF2DD853F91CE08" modified="2023-02-22" version="1">MTNSNPGDACANLKVGFGAIAFKFLVDGLRYDKSMERNIANEFNKNILCPEEQLPRPVVDQLLMLTFSFAVRLLMSIEFGLFPSIVEWQMETLLSAYKILSTKSDVNGIFPFKIIQCSADISHWYWTESEYTAEHKQYIQNFKFVLKLSDFSLTSFEVYKLLETIIIDVETMEDISNVRAVEQQPPALYTFVKQYFVEKLGKKTLKHFCNRPTSNKKLLRYELLDVGAELHARVDFNYYELRDDSGVKWDEYKNIYYFNLDMNNNNTNRARKLELFDEPLTNYTIAIQIDVDKCKGVTQFAEALRKIVVALQKYSGEVKYDEKDQLMSFPPKLAEHFLQRIYTTLTESKLTSICQIGEELDFVETMQNVASTEKLEFVRRKKIIPIEVNTHFFKLLFSLAFRLSLQIERPDLAGKYLKAFGTAYNCIELDNWMKKHSFFQFKINISHEIVEINLPNWKLPDYMQIENMKELRQQKVKRNFDFLLSLSNCAPTFYEILKVAKKLGEIELPKDDAIGELIENDVKKYFDENLINFDKAINLNIDFSPHNELRQIVREIVEEIEQILKNDNWNFAHLNFTKIVEWNLLEYDLHKIGNDQKWEEIEHLRGESQKAYSNWYSEKNEEEKFNYKEMKKLIKVLRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H925</accession>
    <name>A0A914H925_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H925"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14899.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14899.t2"/>
        <property type="gene ID" value="Gr19_v10_g14899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14899.t2"/>
        </source>
    </evidence>
    <sequence length="348" mass="39706" checksum="4CCC3B8655FF2D44" modified="2023-02-22" version="1">MDFVDWSISIRNPSIYLAICITIPSMALYIAEIVTIVRHKQFHNSFYALFVMRAIPDWLGVLNSFYAQRLPSIIGAVLYPIYLKFPNWMLAMDLFLAAHTFQANNLATILILLNRLTAIIMPIKHEKMWRKFLPLLTMFVFCVPILTCWPAFKENGIIQLNNPNSTTDRSFSFMTAEGDAPYLNYIIYIDAIFSIIFTIICVLLNIFTFVAYKLHVKKVSINGNNNGVEIEKKLLVYALATFLGHALVTSLLLIQIISNMNPKTITMLIVYYPLITDIGTVVISSWLLLWASGTFRQQLIKNFVIIRFTDRANIRVVKIEGPQNNNDRAFGGAVGHQLQNRIAVPYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9B6</accession>
    <name>A0A914H9B6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9B6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15405.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15405.t1"/>
        <property type="gene ID" value="Gr19_v10_g15405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15405.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34562" checksum="60C8EFC93860D20E" modified="2023-02-22" version="1">MLAKFVDRQASVAEDYVAFSTWLTNDNGWNEDGGEEENDEGYTPSGDYSTGEDLPSGDLEGADKWIGKTAGDWSPAPEDDRPSGDLEGADKWIGKTAGDWSPAPEDDRPSGELEGADKWIGQTADDWSPAPEDDRPSGDLEGADKWIGKTAGDWSPAPEDDRPSGDLEGADKWIGKTAGDWSKAPEDDRPSGDLEGADKWIGQTADDWSPAPEDDRPSGDLEGADKWIGQWVDDWPHEDVRPFGDLAGADKWADNSLNFDGIYVDSDGQLVFVIKHSGDDGTQKRVLSYQEAMHMDMGGVCDFLFAKIQQKLGMQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9N0</accession>
    <name>A0A914H9N0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H9N0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1508.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1508.t2"/>
        <property type="gene ID" value="Gr19_v10_g1508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="14"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1508.t2"/>
        </source>
    </evidence>
    <sequence length="370" mass="40508" checksum="C5B001B3EDB0612D" modified="2023-02-22" version="1">MALDGSVSSLSKSALSVFVRVRPLAQMERRRGAFECVRVVDSQSLLLVDPEKPSGNALRQNRTHEREFRFDAVLAPGTGEEEVQSLVGTEGLVDGLVRFGLNGTVLAYGPTGTGKTHTMVGTRERPGLMTRVTRALYEQLAEMGDRKTRVYISFMELYNELIRDLLRAEKNGPLELLEDERGTVHIPGLSRVRASNTSKLLQLLQEGNARRTTEPTAANSTSSRSHALLMISLWKDKTERGRLFLIDLAGSERAINTQNQGQRLKEGAAINRSLLALGNVINSLSNASGGRRPAFVNFRDSKLTRLLKDALGGAGENGAGRTVLIAHISPSSTAYNETFNTLTYASRAKGIAFRDELLPLTASILTLWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAK5</accession>
    <name>A0A914HAK5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAK5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1559.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1559.t2"/>
        <property type="gene ID" value="Gr19_v10_g1559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013284">
        <property type="entry name" value="Beta-catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45976">
        <property type="entry name" value="ARMADILLO SEGMENT POLARITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1559.t2"/>
        </source>
    </evidence>
    <sequence length="731" mass="80855" checksum="E72C22F1558695CD" modified="2023-02-22" version="1">MEEQNALNSSAHHFLLHFSRTEHPQLPVGPSPGANAPPPSCGTGSEHSGSACPSPGPMKRFRQIYGASDATSSPSPSTATSRPKNAMDWTESWMVAHHGECAAQPSTSTSAPSVISTGSAVTNLSALSVDTRLTVAVDLMNLEPCQQLLFHQMAKCDGPSSSNNSSSHIENMDPCHFEKMRNYLSLIHAQLGSLDESSEFNAICQLYRVGKYHHFLYCSESASVSSIVQHLVEIILRPNTKSTGNVCLNAIRSLESAGRGFFLNTIILCLRSEVENDSRYATNILSSLFTHQTMGEFFRRQARTQHVVRDLMMALQQDSYGFRHRFLRHIYLLIRPSKELKRFFHQSNGMQMCLDLFEASIDEPMLHACATLLLLLVDDPTGRAMADHFVKLNGIQTLSRRLDHGSSRLLLDIARCLSSCSDSDQLASQSIDGAIQKAIQLLASTDGELVRHITGFLVNIQAKNPGAKAFMQTHDAIPNLLFLLSVWTTSSPPAVVTHKCPNDGSDVKNCELCRHSIAQKEGTAEIVDTVLLALCNLTNGVNADPTVSCLAVMEFRDDPIALFHRLLTSPDTSEPIRVRLLTLLARLLTHLGQNILNRAVQRIVTNHQQKGTSVKDARALAALSLHILNELIKHQFLFDVLISVIRDTDWNPFLLLCSLKDEKLEISLAEFLCRLSSSPVLLTEWTRFSDTLKFCTNIPHVANYVNAIISRIMHLMNASNTVCKRPINGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB33</accession>
    <name>A0A914HB33_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914HB33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15427.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15427.t2"/>
        <property type="gene ID" value="Gr19_v10_g15427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038167149" description="Metalloendopeptidase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="571"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15427.t2"/>
        </source>
    </evidence>
    <sequence length="1102" mass="124893" checksum="1F5AAC10BE058A76" modified="2023-02-22" version="1">MNLLPFWIFLIALKAFGVHGSDPPDEWNKCQKNGNGTIRLEKKCKNHLICYKSKMAKDSGNWKFGGRFRVNNPNKGLADKCAGNDGTKGWHALQVTEEGNGTATLTSSFGNLNGNLDYSSVSSNGLKHLLDINITKALSPIGQSVGEEFLKALRLGAFMKDYDGMALRIAAMELLRSIGEKDEKLCKKTCAAKWEHPTETSPNPLASKKKNVDHFGINCTQIDFADDIPEFVLSISTRALYGLACANLQKEYEHGKYPKNYLELAKQDQVDACAQVPTTSFCNESLALYACYQTESKMSAVNKEIAQICQNHLGILMVAGFRTRICVHREAEKELIVVESILDFSFSDQSYKRAQKFSFKMGEITNAMKYIHIFFIEFGNKHQKSVVREELDGKAISDDSNKEKATIGTVLSSIVRQRINGNWAKSLHFIPPSGRFMPIHFQIPSSKFTQLLTRQTEYLPYKNDPKIIHPSPCDLMGDECELVKEIERKIADLLECCSPKNPGGPCICTLPTPDPKEFTVFPRSAIIKPVNTQDRKPDKVLHTKEQAQQIYESYMKDCADCAPFLKKESHRAKRQAKPNFKKWTKFPISIKFSETLGPNTLEWKDAIEKGTSFIAKDTCIDFTTDLSHASDEGIEVVDIFDGSCGRSYVGKTGKLHQLWINCTDGATVAHELLHALGLEHEQQRDDARNYVKLNRAQIDKKWIQWYEPLSETNNSGFPYDFGSLMHYGSSCDSEGVCDMITLNRFYQQTMYQREKPSFKDLALINFIYCKDNCKGTKNKCQNGGYPNPRRCSECLCPGGYGGTHCELLKKDRDCLDLTAFFGFPKELVADWQTRELKPIMACVGKALSCSCHWRIKPKDGKKVRIHLKMLSETFNCWSSCVESYVEIKYRKDKRASGARLCCSDLIRLETNFTKNWIEADGPDVDIVISAYIKTKDKTNLFELTYETDGAKLVSSSDCPEGANYDTKRDPEYDLICDRDPLTGEGILCCPEGQVCPKKRVSHSTWGCDIVVLNGQYREVRGQNESKNFYFECFKREGESASFWGYWKDKSKDPIRIDDFQCLDYEEAGIKEPPKETVIDYSFKFKSAGDNQLMKKKTLKFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC26</accession>
    <name>A0A914HC26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Chromodomain-helicase-DNA-binding protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g15690.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15690.t1"/>
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    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCT6</accession>
    <name>A0A914HCT6_GLORO</name>
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        <recommendedName>
            <fullName evidence="7">Beta-galactosidase</fullName>
            <ecNumber evidence="7">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914HCT6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16325.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16325.t1"/>
        <property type="gene ID" value="Gr19_v10_g16325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000017">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="9">
        <location>
            <begin position="64"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="10">
        <location>
            <begin position="404"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="11">
        <location>
            <begin position="562"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF01301"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16325.t1"/>
        </source>
    </evidence>
    <sequence length="677" mass="77279" checksum="C170AD8BA2D9FE33" modified="2023-02-22" version="1">MVRWLRIDYCARQMQMLCQTVRPLSTVTVALLPLLLLLLHCLPIHGTETERSRSFQVDYARNVFLKDGLPFRYISGEIHYFRIHPSLWEDRLRRVRAAGLNAVQLYIPWSFHEQKVGRFNFDGGRNISRFIRMAQQNELFVLIRMGPYVCAELDFGGFPWWLTKDQTDISLRTSDKRYFGHVRRWFSALLPILRPLLYKNGGPILMVQIENEYGSVSPCDHNYMRWLRDSVRESLGDDVVLYTTDGPSEKMLRCGSIDGTFATVDFGIQPTEESVKELFELQRNWSRGGPSVNSEFYTTWFSMWGDKSMVRQQIEPLVHDTRRHKFWLLEWKRVKWAGDHIVRLCRAHRRGRKNWPNPPLPLPGNRTGVSIQNVFGVKLADFIALTNSSSNASENRCIHSADGPLNFEAFHQDYGFVWYSAFLEVNGKVLELPELRDHAYVFLDGKFQGNLSVGDKTGGKTKLGLKGEAIKGQKIDILVENIGRLTFPLTKVDPRGLFSPPFIDGKVISDRWVQCGVNLDSVQAKIEAMMNERANSASHPHIDEKHTKVHSISHEPSIFAAKFSTSNIDWAEMDTFLDTRGWGHGVALANGFNLGRYWPLQGPQAAKSSTHLSILCRNPCTRGVRMIVIRVMMLLMSPKGLRHSHETFGSRRPFRIVGAFIATIGAVVATILTETIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDB1</accession>
    <name>A0A914HDB1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome activator PA28 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDB1"/>
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        <property type="gene ID" value="Gr19_v10_g16069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
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    </dbReference>
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        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="1">
        <location>
            <begin position="57"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16069.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23562" checksum="4E8AD60DA866E6EE" modified="2023-02-22" version="1">MGSNEQSEEFKALVQRLEEELKKKVIETLPQMAVQMDVLSAKCLKAFKRGEHSKPSEEIIQLMDEVRPFYIESVSDLHLIEAKLRQMTSDVKLSAEVLTGEVLDRSLKLTEGLRKDLADELKILDNYHNERSYQLRKMIKYPSQGDAPLTEFDRKTVTNLRINLAKCRNLSIALHSILSENMEHFVGKRSKKDKQDGLYSMLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HED8</accession>
    <name>A0A914HED8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HED8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16743.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16743.t1"/>
        <property type="gene ID" value="Gr19_v10_g16743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of mRNA processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF8">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="331"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="717"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="626"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="941"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1072"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16743.t1"/>
        </source>
    </evidence>
    <sequence length="1120" mass="118014" checksum="2E543F52FB9787B2" modified="2023-02-22" version="1">MPSSAPTSPSLWDLGALKTEGHDVQTYRFNMAELQANQLESKVVDSSSDVMILEQNGENAEQIAAVAVVEAVSNEEGGADKLDNCAGVTEPGGQSLLSQDAVVVEQGQKQTPDADTLAQQPEEKTVQETEKNGEESSRPTIGQNDVVVEQQPVPVVPPLAAVPAQNDDCGEEDDEPDIIIESPPKHAIKTECIEEVVVVGSSPAAAATTSVGMNPKESVTVTTTTALSSIVQQQKKVSNAATPTTAAVAADEPLSSSTTNATINNTTSTTAKLVAHVSSSSTTASTESVVLITDHRAAKEVANVAQIDGKQQQQRQSVGSENLVDGNNLSASLWIRNITTTTKAADLKALFSKHGKVITAKIFTTKNKQSPTCFGYVTLADAETADVCAHKLNRSNFKGRIINVEKADRSNLSQIGTGQQQPTAAAASGTSKDSASGTPRTSGKSGGGSKSTSGDPGASSSSSKKVRPRIVAVPESPGKKVSASSSSIKKRITKHAGGGGGGGGGGSTSNKYDYNSRNRNNRRNFRSRVAPFVQRGNAVSSAQQYMVKARVEQPPSIYRRLVHQTSRGIRVSASMYDGSSAAAQYGQQRMDSAGFRDFPSHRQHHAAADPRADSRRFVPAGGNDEREEMLRLMRRREEEHRKKEEELRLEREHERLKYEREKLERERLELEHMKLAAQIQASGWIQAAAMPVAAAAGLAASPAAGIVGATTVSARAASASQQQQHRQQVDSVARHERHHMEARTSSKKDSTKMSAPMGRSSVGGRAKESSSRSHHDARRTSPVRAQRRSRSRSPLRRSSTRTEKNASQTASKGSSASTWTTKSSTPSAMSSRHVKQRDGGNGRRSSSRGAGAGAGGGSVAHHQSSAYAAGDAGGGGTLHPFAQPFGSATLSAYEKQNQYTIGDGGSRMTSSAASGGYERHGSSQNNQLQGRSFYNDRYGGDTQTATDPYTGRTDLSYTQRIGQYSGSMGGGGREEVFGGGSAAFGDSGLSSYSSSAQQYGGRSHAAGQQQQQQQQASYYNQSSSWNSSGGADRAADVVNSRAFNATSTSGGGGGTSGWGRQADDILTEWNMYGSSPQKDNNPSSGGRFQQHQSLSSSYGGGRSGGGSMFSGGGGGGGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEX8</accession>
    <name>A0A914HEX8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEX8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1599.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1599.t1"/>
        <property type="gene ID" value="Gr19_v10_g1599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="6">
        <location>
            <begin position="405"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="709"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="670"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1599.t1"/>
        </source>
    </evidence>
    <sequence length="822" mass="91354" checksum="1091D8B93A7AFBE0" modified="2023-02-22" version="1">MSNKLPFRRLFPKFYKFNSDFWFLKIFLTGFPNSVTPRKSLHRTFYSLLNPRVTTTRFRRSATQSASIYSALVQYLRQRVGPSTFFMRRLLAGGRQDPHYQCPAEAASPPPLSAFHSPCSILPPPPSKFFFDIERQLSARLAGEPLLRSAQQQPTPPAEAASERSSPLETPPVLSAATTAESQNANDTLTDASETIISFQQQRQQNLSANVVGHKQQQKGIDAFFAALTNASRDNGGSSSASYQQQQMSLVEPEHQNSRRNFFTQQSPIVARLSSELCAPQHIAHEPSAQPLVQKIQNVTNTSLSANLFVSALAAQHQQQLLHHSGRIPSTDSSMKFQPAQPQLDNSLDIQRIDNQSSSSRSKMAEQQQVNTTATMAMNSPLSSEGVFIVPNIRSVDPGPSLSKPIPLLGERMDLLQFKRKEPREWSSDDVVAWILDVARRHQIPCENLNLAKFANCSGPLLMLMNEQRFKEHDPNYGSLLFAEFCKLVTDENFIDEWMKVNGSVATPSSALDPPLLAQMNVKKPAASTLLQQTAFLGQLAIQQEKRQQQQLLESVTAVEPLVDSASVTGDTSTSLFLRVAVANNQQRQKDAGGCPLPSLNRLLPSPSASAATLRQPGPHVSPASQLQPSLQQEAPNNNRGALINHQLSCTSNLMMAQQQRSHLLKPMTSAGTKRGVGRPAGSKNKVEKFVKRNKDGRPRKRSQHTKGNKLWEFIRDALKDPRTCPSIVRWEDPAEGVFRIVESERLAFLWGQKKNNQKMTYEKLSRAMRTYYEKEILVPVPKSGLYPKKLVYKFGPTAHGWRTAASLAVQAQLVLVGGSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF25</accession>
    <name>A0A914HF25_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Zinc finger protein 593 homolog</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Associates with pre-60S ribosomal particles; released from the pre-60S particle very early in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914HF25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16554.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16554.t1"/>
        <property type="gene ID" value="Gr19_v10_g16554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00068297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16554.t1"/>
        </source>
    </evidence>
    <sequence length="437" mass="49397" checksum="FA1889D2D3C2CF6C" modified="2023-02-22" version="1">MLASNGIDSAKIKPGILRAKLVFSFDCFPLLPQQTKKRRRPMTVTTNAFPSSFKEITLHDVWANNLEAEFAKLRDLIDAYPFVAMDTEYPGVIATPVGQFRSKEDFNYQQLRLNVDCLKLIQVGFTLTNEKGQLPPGRDIFQFNLHFDPSTDSFAHTSLELLKAAGFDFNKHQTEGIKLEDFGELLTTSGLVVEPRITWLTFHSCFDFGYLIRAIMLVKLPEDEKDFFRFHRKLFPNSFDIKILLRQAGPRDAMLKGGLQELADQLHVPRIGQCHQAGSDSLLTAMTFFKLQELFFAENWKEVASAVQGHMAGLSNSQNGTINSINNNGENLDDILMPKKHTQSNKTKKRAGRDLDEIHADLIKPGKVAKLQNQLLDDDLPGRGQHYCVTCDRHFVDGDAKARHERTKGHKRRLHALKEKPHTQREADLAGGLGVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFY8</accession>
    <name>A0A914HFY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dopey N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g16810.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16810.t2"/>
        <property type="gene ID" value="Gr19_v10_g16810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="7">
        <location>
            <begin position="1451"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="6">
        <location>
            <begin position="2362"/>
            <end position="2716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1242"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1424"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1483"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2272"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2717"/>
            <end position="2738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2752"/>
            <end position="2772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1496"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2289"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="2310"/>
            <end position="2325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16810.t2"/>
        </source>
    </evidence>
    <sequence length="2811" mass="309551" checksum="B3010C03B0D35101" modified="2023-02-22" version="1">MSASGSHHSEASTSSSFLLGSTFSTQQNTSKYRAYASAVDKALKSFESTTEWADLIAALGKLGKVFASNSKSFSDIPNPLTVAKRLSQCLHPALPSGVHLKALETYRQVFNILGHSGRNQNLARSLFLYAIGLFPLIDHCGIKVKSELLSIFEHYLLPLGIDLRPALPGFITAVLLALEEGTEFYGRAFKLLDQLLDKVGSDAFYTCLWQAVGGSSSVRLPALIFMNAKLEKRKSAQPSAELLHTLAGGGSVAASSSADCHHQQQHMLRALCAVADDASSSSALAQRHLLDFLCTAIPFDSGWVPRRELIQLLRRCMFIVLRRDMSLNRRLYQWLLNRSNDVAFVGLPVNGTEESVDLVFFKQYTLPLIKMAIRDYLHSADTVEVPPLSTGTIRRYGTLLKDPQIQFPEVRVCRILHYMLDRPELGQMVLEESLADLLETICARDMDLVRDMQSDCEKLEPNFECFWNVHTMTMDDEQSNRRADEIKKNFNVLLNSLDPGFLWNFFKKFFSNSVNDANAVDDGGEKNSGRDKSNNHGAPLFPLMVAFCVRNVQLDSHGDIRGRHLPELLQNVLSGMVTMCQQRHSTAASDDDVDNNSGTSLCCASTECCMLANIVLCRRLLAEITQNNLSMVFEHIHDDSESSPSKKGIKCNEELAEEQKLVERCLTACLCLLTAVCEWYCADRERRLVGVLAALFALMRDFADFPFYSLQLHNNSPQHQSTACRSLTDSLHAETGGHHQMPAWLCSVLRLIDPPTWATSKFGFDFELRNQLFDLLLYMCVRSASMIEQHTAVFGRALSQRSAKGQPKQKTTTTVLLKPFLSLADLQRIEQEGLCRKAAAVLWRRFADEQTTAAADVDALMPIALLLLRLHSRRVSETSSEVEDIVVTELTSANKVLSGGAVRKFRDLWVFCRNAVIEEVYTGILLKPMNRVVMVLLGFIADDKLCTEQVELRALAYSWFMDCAHHNELHKIVQMLTLMLLNPVTTRVSIQFVQMRKRVTREQLSSMPAEANCVALTTVSGKQTFHHVCTDVEQRRHGNAWNNYSYVDCDPRMAWVSDLNKQLLLSDGGSNNVNGSFSGFSTPVHQQQHGHQNGWVMMNNNGSNNNNCSKNVSSPSPSFDATQMSAQLPQHNTSALSMAMIGSGNTTSSAKGHRRTMSDIPQFDGDAESVDSYSMDTSMLDSEVVEAVQYLVDSVCDEEVDEEEEGTKPCIDGDEDIGELEELATNMLDQALLDEDERSTVTPVVTRRQRQRGGDVQSGADGDMFNRSADKRKRCASAVRESTYDQTSLVGSLLGPGDAAAAVPRITSYAGGDTIRRIRTGHRRQDSLQESIFSTGTQELRLFDPTELPNSTCPGDHKQPLLDETFSHMLFYAESPSIVDLGRAEKLFRTIGTLLRSGNNSGLGRHLVNCMLFTNMAELVNRAGSSSSNCKSSGSNGSSNSGVNTTTNSVATIGGASVAATQQLLDFMARHYQHIQGEGFWSTAQDNGGQKEDGATASNSENKTGQQRHSTLFEIFSTVVLYFFRSYYLNSPTNHVSETDLVLSWKCKIAALDCFTVLLNILDDIVKEASSKELATFVQQIYRQTKTQKVILTLMLAAIPTPPNQKDWRMPLSMDIAEFNNGPSHSVHFRDLIFAYHRSLLSLASALVVLEYSLHVGTRHFSSQSHFGFPISRNSSPSSQITENQINYNSSQNRSTIREARYSVVELRLFLGVILNALKRCPARHELWLHFLIGILPYLDRALATFVVHTVEQICRNLYESVFINGSAVSALNTPPPLMTRVNHQISSVLEHPKNPIQFVDYRISRTNDLAPMLDDSGVMPVIYPANYVLMLVESLLSLMHFCLLDTHNNNTSMFSLSPFLPSTKHSVAALAHPLQPNFHQQSVTPLRYSVVASTGATGGGGGGGGGAFSSSNMTSMVGSAISVIPGTGLINNLFGRVFTSGENPSNIATRADASGKSAEMLEAQRELIKRFPSALAIFIDVWAFTEQQRRRGGTNTSTPKSLSTLILDILNPVAKRHKNALMNSLGVVWMFRDFHASGIKMSDNCRCSFVYSHQQIEVANLALNLKSLSLTSIICSVSDTLKESANKTTKSSSSSSTGSDKIGAAGGGFSLEVAMLEMLHQCTRQVSVNELRESWAALAILFNDTPLAQLPARASFLEFAILTDFVRRCGSQAIIEDKQISKAILDVCQKLIEAINVVVGWQLESTTWLKRTLVVRQDASTSQKMAASSDLSPVLEQRGGSVVGGASVSSFGAAPLLSSASALASESNSMRGSTISLTGGGGGGTTTAHGPSSRLSFPLDTQSMTTASCGGGGGGTVTGGGGGRVLPTPSTAAAGGGGGTSSASSVLRSSMKDSSSGSGANKKDPSDSTQALFLLAENLAELIDSVCKSEDKEKLLPALQAVWNNTLPYLKAKSAKNVRFFLASSQFLASMSSYNYMRSVWKKNAMDLLWDNSFFKMDIHSLRQWLIVIDNLMTNDKTSFKELLTRITTSTSTTLSTLITSKEQEYEMRAQYLKRLAFVILSSELDQYAGQLNEIQERLTENLRLCQVPVIHTQVFTCYRVLLVRMSPSSFVSIWPSMVTELVQVLAQIDHQLSSASGTGSGGGGSVDEQKSARDEQCMQLFLAACKLLETLCTLPSGYMSQFQMCRWTFISPMNAMSVSDVFVPYAVRLNHLLNNRYTELTGADIEMRSASLFNIKTLTSYQELHPFFHALTMQNGGGSSRGRQQSSHHNDEHHQHHKYMLYNGRLDGDSNAIDHEEGTGTDNAELDKNHDTAPRLRDAELLNGSQSLKNAVARIEHSLYVDFAEHWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGA1</accession>
    <name>A0A914HGA1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HGA1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1710.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1710.t1"/>
        <property type="gene ID" value="Gr19_v10_g1710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="340"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1710.t1"/>
        </source>
    </evidence>
    <sequence length="614" mass="70045" checksum="CBAA233D1CC584C6" modified="2023-02-22" version="1">MSLNSTISEVYFELANARPCWTLIIFASIYTTLAIVGIFLNLSVIYVTIRTKSMNKSANKLLAIYSFFEIVHQSGHFLFAYSVISGQYLMPYKTVIQILTPSYFAVSCTLFLLFLTSIDRLIAVIFPLRQSENVLFYIITLPFIGLCNVLYLYSQSCDSVDKTLVTVTLGDIGMASYQCANSPEFIWPTIISLILLSTIVLYAVVAIAIYFRKSPPNSNSHQFNTRIFRSLFCIVSMNIGGYLLNYSYIIIIPMLGNEMSIWKWSQIFGILLNISAASNAPILYFTSTEYRKAFDKEWQRITNAFNRNSVYLELANARPRWTLIIFASIYTILAIVGIFLNLSVIYVTLRTKSLNNSANKLLAIYSFFEIVHQSGHFLFAYSVISGQYLMPYKTVIQILTPSYFAVSCTLFLLFLTSIDRLIAVIFPLRQSENVLFYIITLPFIGLCNVLYLYSQSCDSVDKTLVTVTLGDIGMASYQCINSLEFIWPTIINGMLLTTIVFYVVVAIAIYFRKSPPNSNSHQFNIRIFRSLFCIVSMNIGGYLLNYFYIIIIPMLGNNQMAIWKWSQIFGILLNISATSNAPILYFTSTDYRKAFDKKWQTIINLFNRNAVQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGK7</accession>
    <name>A0A914HGK7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGK7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16771.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16771.t1"/>
        <property type="gene ID" value="Gr19_v10_g16771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036745495" evidence="2">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16771.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14015" checksum="21F44CAA62D00F05" modified="2023-02-22" version="1">MNSFILSMLVMLVNSLLIPCVMTFKYLEPNGTTGLDINGTKADNTASSSAWIIWTSIGIGLILLALLVIACFWKWRQSRAPSIVVTRAGDVTTEMEMVEIPAPRRWAPYDGAWDVATCRFKGGKALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH94</accession>
    <name>A0A914HH94_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH94"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17491.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17491.t1"/>
        <property type="gene ID" value="Gr19_v10_g17491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17491.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40613" checksum="79D09CCFE00850CD" modified="2023-02-22" version="1">MSDNKSDEEQQQQMEKIFICADVWLEVFTFVIPFDLGLKVALISDRFDALVDVHFKSREWSLDWMKIRRATDGNGARIVNARSREGLPIPQGPLPDKVISFKRISICYIDQSVIEFLQRIRRLFDSSGTNVFIGTDFDQNRSWGIIRQKIWPLVNDNICGFLRLDSSVLGRLREFSSTILRNCAKLRSIHSMGVFPKFPAEDNAAASSRQVLAKWLLTPRGDGLPKVLYYAFYGTTMDQFIESFGNASESANFIIKILEDGGFVPFELKNSWTEERLSFRQIDGNEWLLVRCPIEREEDKWANWEKEAIEWEWSRQWRRQWNFIAIDFQDRDIGDGMVEENEGPSEPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHJ8</accession>
    <name>A0A914HHJ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHJ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17568.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17568.t1"/>
        <property type="gene ID" value="Gr19_v10_g17568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17568.t1"/>
        </source>
    </evidence>
    <sequence length="446" mass="49429" checksum="793E56C4487BDB09" modified="2023-02-22" version="1">MDGGGIVHSNASNSTSSGEVKCLTEAQMQMHGSEFERYLQRYLFLGLVLFGIFGNSLNLTVLLNPKMQSRANTFLAMLAFADIVFLSLLMPNVLANYSLFSSVALFRLLYFNAKVHLRSIANWASAVAIWCVIAVCTDRLIGIRNPLFARGYVSRRKMALLMGSILTVPALLTAHQHFSHECLVRFFCNGTQIQSICLPVTQEQWLPNKPNPYSLSFRRFISVSTLINTVISVIFPIILLTVLNFLLLCALRRRKQELDNIGSKQIKPSKSTSSEGFSQQIVHSKTEQRVTWTVTLIVSMFTLTNGPSAVVNLIEGFAIAPPAEPKTWYNLTLIASTLVILGKVSNFILFCLSSKHFRRRLFVLAQKRVHGRLASFPDRRRSSYTAMSSATRKGTPNKSSVVGGGGGDTRRTSQVPMAMAQAEETADGERLPEGTNTPPKTAEQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHX2</accession>
    <name>A0A914HHX2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHX2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17521.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17521.t2"/>
        <property type="gene ID" value="Gr19_v10_g17521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039161">
        <property type="entry name" value="C19orf47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21359">
        <property type="entry name" value="DUF5577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21359:SF1">
        <property type="entry name" value="DUF5577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18017">
        <property type="entry name" value="SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17521.t2"/>
        </source>
    </evidence>
    <sequence length="364" mass="40437" checksum="281CC6EA7C577621" modified="2023-02-22" version="1">MSGSSAAFERFFATCGIPQTMVSKYASRFVKERIHPALMRDLGKEDLRELGVSALGDQLAIMRYIKQCDGNPPEFNPSDSKRKSESRQKETAEFASDEEDEPMFVDSNPSNIFKAPDREDIYHVKMPAGTLPKTRKMLEKNRFLRDQGVLKRGVSGIRKSGVELSKPVLNTISTRSKVIGRKPTKIQDTDITSSTAFASLGSMRSDSISTKTTVVADLSRNSQRSVSLANRFASLSGGANIRIQLRGDAASQPSQRRLINYGNSDIVDDSTAAGFYEGRPKTIGIRRGNFPPQMVRVRKSDLQPEVRRAPIAERIQIVGQSRRSRPVITVRGEERTAAMDTVGRRGWPTPMKRTSILDRISVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HID2</accession>
    <name>A0A914HID2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DJ-1/PfpI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="Gr19_v10_g16901"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
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        <property type="entry name" value="DJ-1/PfpI"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
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        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
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    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="465"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="102"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16901.t1"/>
        </source>
    </evidence>
    <sequence length="697" mass="75158" checksum="5236F6556E1DD1FE" modified="2023-02-22" version="1">MATFKLRQGVDCEKKLEPAGETQFLSIVLFTDNASAMASCVAIARCFSLFSLKSKKDNNNNESLNVQVEIAVKQHQSLRHVGRQKNICRTMSTELISTCDDIVGLQDRPQIELARKAKLHVDSLSKDVLSEQYVAVVLPGGQPGSNNLAADECAGQVLRRHEAAGAIVAAICAALIALVAHGVAKGGTLTAYPAVKDQITAGGYTYSEDNVCVYNNVVTSRGPGVDVTIAGLQDRPQIELARKANLHVDSLSKDVLGEQYVAVVLPGGQPGSNNLAAGILCFLSSLLTGYVCGRMPFLLLTVFCACVSFIPCLSWWYFTLFILSGLFSVTFSVVFAYVANSTERHERGTECRLIATFTASLALGAYLSSVYSENAVVLLATCISALDMLFIAVCVPESLKPFAGGECSDGGAAGHSASGRVSLLKIKGKDPLFVLRFLRDHLTVLRLCAIVFLTEASQFSCFFVYPRLVVGFSPEAIALFVGVLQTGFLRVYNNVVTRRVDARLKRGCFILAVLFLFLTTTCSAQSGEPNSPADAKTNVPMTFKEYTDFKTSLVLGEVHTAIATSDVLEKRIASAIQASRYDGLLFWLALNATLCCLGMTVAGLLLLLIHNIWKISEDLQRLTPRISVIEQDLTTLTANVATLTANVATLSNNMDTRFANLDTRLIEFSHILTNAVIPRISALEQAAVPAGADESME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJA4</accession>
    <name>A0A914HJA4_GLORO</name>
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        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
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    <comment type="similarity">
        <text evidence="2 5">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="gene ID" value="Gr19_v10_g199"/>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EP450I"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
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    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037517997" evidence="6">
        <location>
            <begin position="18"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g199.t1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50967" checksum="78EEB35C4F03E58D" modified="2023-02-22" version="1">MFLVLFLLPLLLLFILAFKHTQRKRASHRITLAEDNNLRHIELQDLTAKFGTFFALTGQNGGNEFVTSDPAVADEVFSKKFFAFGDRKGFHSHAGHVFVASGGHWKELRKRVSFVNAKSRLKPLEPLLRDSVGPMLGKMETNVGKVFDFHITSLHMTAGVLARMAFCTAQPCRLLDQFCETYTDFAEQLLLAKELARLSPQRNTCALPRAIEDGAREKQMNVDLFMELYKHIKEMEKQKQNEDCDKVDVDDLDQMAQSIGTLFLENAMKSVGIDTIGHCLALLVHFLAQHPDVQQELRDELLKGDDDPPLLMATVKETLRLCPIVSFANTRDCTSPVTLSNGAKVNIGDSVVVDVFSMGQNRAFWGEDAHKFSPQRWLAEEPCDNLRRHWLAFGLGPRSCVGKQMAEDLLKIAITTIFYRFRISSEEEKFSFRLSAFIWSVPMCCGRRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK51</accession>
    <name>A0A914HK51_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17612.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17612.t1"/>
        <property type="gene ID" value="Gr19_v10_g17612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17612.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24002" checksum="550906269035C5A1" modified="2023-02-22" version="1">MVFVVSTTLQRLPSPSATKTLAQQPYSNYQFQPNDGRRRLIPDFCCAAPGRLGLGFHRKFTLAGPLTGRPHLFDQRLVGVGAGAGPVAVGPVLSRRPPRRQCPIFHRLRITKEHQRHNLLVAQARRNAQIALVMSPYRKFQERLQAAQRRHLQQKAKRKFSLKNGSVESGAKRECAEGRIRGTSNSSVRRWRMEIGAMIVGQRQRGGDVHINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKV3</accession>
    <name>A0A914HKV3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GYF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17802.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17802.t2"/>
        <property type="gene ID" value="Gr19_v10_g17802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="3">
        <location>
            <begin position="265"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17802.t2"/>
        </source>
    </evidence>
    <sequence length="970" mass="106309" checksum="1E8C36D677182555" modified="2023-02-22" version="1">MASIPATNNLPIAVNNNSNDAQMNFNPSWMQSTAPPMQRSLSVSNNSTSSVINAKKMVTENDETCEPIFAKHSYGREDLLAMMGKNTMKPPLGIKRCPFYMDTAQTPIILMPFSDTEMRLQQNMNSSKAMSTKKKTFSRVEPTTKSSDIWPRRTVGIGAGGVQQQQHVQAPPQAPQPLKVVASANNNFSSTANNLATAGASPPGNNNGSTGSTNGNKKATESAPPTAAATTTVAATAKEPPSLATTKASAGETLPQTAPATAKATHHWCYLDPTGVQRGPFDSQQMQAWFSSGYFSDTLRVRRKDETTYIALGELFLINGREAPFVVKTVTSLPSQQQTATFPTVQQQRISPSELREATTNATAAGQHHHHPHISPTMVDVERIWATTPLEDAVVGAGGGGGAVTASNGSTVTTAAAASSAVGGGGAATAPMTMMQSKEFKILEEQRKLREKEELLRRNEIERAAKEQRVREMESELKRQQEELSRRACEKDAEFEQRCAQMAEYERKRREELAALEQRIRAEHLQQQLRLEEEDRRRAKEAEELVRRELERQHQLVEAEMKRKRDDEDVRLRLAFQEHQQELIKEKARRAEEEQRRRLIEEQQRHQQKALDEARAERTKQQQAAAKAEAVAKAMEQQRVNSLANAQWQQQQQHQPMVNSNSYSFSQPPPPQQPPIQPPSTQQQTRATAWQTISTPLPHPIGQSPPASFLQFPFQPEQQQPIAQQQPPAVTEQRRGWQPVQLPKAAPIPPAINKPSSGGGGGANTKLAFGNKNNKQGVKHPQKGGGKQQKQQVPPPVEDKFTAWIIKRVKELNPSVDAEVFATFISGIDSPNEAEDYIIGYLGENKEVKEFHRDFLQKRIELRPRAHPQAPKDDLSRPAAAHGADSELHKGAGWASGGGASGAMTNSSGVGGAAAATTAVSNANKKKQKGQKVLDLSTLGFRPASDPNRLNAGEIDSVPPVPGGAGNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLF5</accession>
    <name>A0A914HLF5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17709.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17709.t1"/>
        <property type="gene ID" value="Gr19_v10_g17709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000028">
        <property type="entry name" value="Phosphatidylinositol transfer protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17709.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31308" checksum="C32A69FE3BEEA065" modified="2023-02-22" version="1">MFTKEYRIIMPMTVEEFQIGHLWTVAEAARQETGGGEGVQVLRNEPFEGVNLFHGEFTSGQYTHKVYHVDTKMPAILRAFMPNGSQTLHEHAWNAYPYCLTTLTNPDYMKDDLLVQIETIHLNDGGTAENPFRLPPDELSRRTVVNIDIANDKEHLSKSDIRDETRPSMFRSEVTGRGPLRGAWQENTEPLMCCYKLITVNFKLFGFQTLVESYLKKQFPRLLSKFHREMFCMMDRWHGLTLAQIRVLEEETQRQLDEMRATGNPRGMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNG4</accession>
    <name>A0A914HNG4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNG4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3139.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3139.t1"/>
        <property type="gene ID" value="Gr19_v10_g3139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3139.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27275" checksum="77F7C58F2D9A5135" modified="2023-02-22" version="1">MSHASETDTKIDTERGKQKLRYDGRLYIYDKKSVDGTTKFWRCEFKTEGIDKCKGRIWTTLQGVFVRMVTPHTREQNPAGVVAQEVKTGIKRRAACTMEPPSVVRTHVLENICSPALSEMPAKKATNEESNREWSALMEHCYGDGTFSLSPPLFYQIYAILARRGRWIFPACHALLTCKSQSTYERMFAMIQGKWPLFRPSTFSIDFEFAVSNAVQNVFGGHCDIRYCFFQREPLSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPJ0</accession>
    <name>A0A914HPJ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g2515.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2515.t1"/>
        <property type="gene ID" value="Gr19_v10_g2515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="1616"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1343"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1460"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1516"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1344"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2515.t1"/>
        </source>
    </evidence>
    <sequence length="1653" mass="185188" checksum="EDF69DD4DF476204" modified="2023-02-22" version="1">MKTFIFSLFPIIIIITVFAWYDTVVVPVTAEKDHRDISELLSDTADARQLNEIKRSNVMPKQSPPPRAIDIKRVPFTLPSAAENIRAVRRCQFSNGTLWPSATDCDDELGSGACETIFSANKVLRRTKESSRPLACLNKELADLARRCAKTCAFCCETPQFNCKDSGGTLIDCEKHKAKCKEPSWRRVMMSVCEHTCGLCAADACFDAADDCTSLRHLCFHHAVSPLVRQQCARSCGLCKPEDAARRSTASQEVLDVQKTPKEVIVLVRKNSQITSTVMPKSALCQDASSSCADSAGLCNDKIYADFLKDKCSKTCGHCKAENERESDDCSSGQQDNEDEDQQFEAVRHIRNRPSAANNASGIKVLPGGKREKLPKKSNDKFSDGLIIKFRGGGHNEEIVLRGQRGETLRISRELLLEDDEQSAFCDIGKSPAVNGKEETEKKKNGTGEIAQGQKRGRQLEKQKERKKKHKDREAKTVNELSTEKQSDEEEEEEEETRETEEEEEKSAGNYRGDERMRKDERQIEDMMVKVVDKTPTQRGRNRINREQRRFPAPRSLGRINHHSFSLEGRSSRMRSIPDEKVSDAKSLPDEKASDAKSLPDEKASDAISLPYEKAFGAKSLPDEKAFGAKSLPDEKAFDAKSIPDEKAFDAKSIPDEKASDAKSLPDEKASDAKSRSDEKASGAKSLPGENASGAKNLPDEKASVFRDESGSRGKNQLTDQNARAKNLTNGRAFSARSLPDERISENKNLADQRSSAAEAFPDQRISKTKNLPNRRASSSRSIADEKSLETKSADERLASRTKNPKEAPSDTKKLPEQKPSPGTVSGNSRLSQRILELLKNLKIARAAVTNYDTRRRRKRSSNSDQQNPTVPDQNRDHPKQNSTIAEQNFLERFPEEKPPDELKMEEAKLEKMVEEGQKMDEELLHGMIEEEDKLEHDEEELVEKIIEEKEKPNEESVDGIMEEEEKAHEKIVDELLEQLGGRYDAEYIVVKAMLEEIGAVSVDEPYNNSQRAQRLPKLKEELQESEEDVEEDDNDSGQVEEEYDEEEEDGNEDYEEVEEQILDDQWRPKVKVDDQDRAVPDQEGDTFPDDPVDEDDNNSLPDDKVRQFDTFAAAKSPKLTDFDRSEDDDWSKTADGRRIDRRNQMVHLRTNPDESRISVFNLNIMITYLIYCFLGGIRGALERVRLRYGFDNGTMEEMLANLLLDTERDIANGLKAILGELRTLKNSDGRKRTAELLRDDDDGRRGSTASGRKPMIGRDDDERGDDQSERATIRKSGGRRKKKSGNRRQYDQDNRTLRQLLNLLVDKKRAESVQNVVAKADNGGEDALPSLEELLELIKNQRKAMDKKTKSDKDGEEKKKPRPPPLASRRLRIVTARAASAIPRRTPSANVVLPRRVVLSSGGPISSGYRLVPIVGPGKQVSVPAQVYVTGQGTFLPPVNAGQQPAYPVPTTHFRPQEGQAVPAAQPQQIQIQQSPNQQQPAVAPPQQIVVQLPQQFQPQSQFVGQQQQLQPQQQPQTVYVQPQPSQQIQAVPATQPQQQPQLVVQRPAQQPLLSKPQQQQNLVVVDTPPGPGPSGLPRATVPFLQPSRVSRGSYAMLRNNVVGGFVGPAATPNCRDYHPYCEQIVPRGFCFSELYSLRTKREYCPQSCGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPX1</accession>
    <name>A0A914HPX1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HPX1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2802.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2802.t1"/>
        <property type="gene ID" value="Gr19_v10_g2802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF139">
        <property type="entry name" value="SEMAPHORIN-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="3">
        <location>
            <begin position="30"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2802.t1"/>
        </source>
    </evidence>
    <sequence length="739" mass="81685" checksum="EF1D72357B9E26DB" modified="2023-02-22" version="1">MYTKIGAFLCPNCRRTLALCPLLAAFSHILLSLLFATVQSLSVPIEADNVFLSPGVQSFRSLLVNQRLSSLYVGSRDHFFRLWLYNVNDTSSAALFAHRQLHVRPEEREECLRLGNSERECDFWVRNIFLRSDNNLLICASQAMKPQLSVLDGQSLADLDEARTQIGICSQHDELNTTAVFSEFGNPDGLPALYSGIRTGLSLENHLIYRPPLMRDGREVHPALRTSIYDSNWLNEPQFVASHSVGPHVFFFFRETLTTDCYNCPSAGTGKGTTVSRVARICKNDLGGRQVLRQVWTSFVKARLNCSLPGGFYFDRIQSVSRVDESLTSAEASTSTGGDTFFYATFTAADQSALRASAVCVFSLNAINQLFDSGLFLEQSVSGSGSWWNPTPADQMPTSRPGTCQSDSRQLSDEELHFAKSHLLMAESVPSLGGSPLLHRHDVLLTQIVADVPDRDGRIVLFAYDLGRHSLLKMLHRLAFPSSARLLAIYRLPPSKKLHAMAILPTEYLYLATEEKIAQFRLGQCAVYGSNCAQCARDPYCSWSITRRQCFPTDSSHSDAVGWIVSRGVSAAATFSSVDEVSERCAKHAKAVTMTVFPGDSVHLECPDGEQTVQWRHNGRKVASENTAHLIHSRSGGLVLLNATEALEGVYECAMDASESAKAKVPLVIYSLKVDGEDCARPKSVEQFRSAQREWCRRMDAYRSNLSKWQSAHEANGQGGGDCGIGAETERRTAENFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ61</accession>
    <name>A0A914HQ61_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ61"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3627.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3627.t1"/>
        <property type="gene ID" value="Gr19_v10_g3627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3627.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9052" checksum="31324B2CAECC0078" modified="2023-02-22" version="1">MPTIFEIKSAELKEDVNSYFVVRAKIVRLEYCEYLGCVFCRKGKCQCPEDKENFLYLKLALADETGSLKLSDLSMLCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQT0</accession>
    <name>A0A914HQT0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQT0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3594.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3594.t1"/>
        <property type="gene ID" value="Gr19_v10_g3594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3594.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19020" checksum="8BD951E83A461139" modified="2023-02-22" version="1">MTAEKDEVIDKDRVRQAQAKHTAKHHNNLINGTEPNHRSRVIRFYWSTTDRGRHFGCRGPLWSGYETRQPTEFRLPVLGRVVHRHANQLRRQYTFEDHPNANNPAPAPAMESPQNRTPIVLQIIPRSPPRPQSPSLAQRRTRQLPKTIQRFSHKSPLTDRFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRL1</accession>
    <name>A0A914HRL1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HRL1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3075.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3075.t1"/>
        <property type="gene ID" value="Gr19_v10_g3075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01372">
        <property type="entry name" value="KISc_KIF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000011">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="12"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="486"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3075.t1"/>
        </source>
    </evidence>
    <sequence length="592" mass="66493" checksum="DF558BC0D49EB81D" modified="2023-02-22" version="1">MREKSATKSSSSVRVAVRIRPQSVHERVQNVPQCLTVAHGKPQLTIGREKTFTYDYVFDQQTPQEIVYEKCVEELVESSFDGYNATVFAYGQTGSGKTYTMGTSFEPDQMNTGIIPRAVEQLFDGIYERRETARRAGKVIPSFEVSVQFIELYNEELIDLLSSDSDCSAAITIHEDPVRHEIYLRGVSSRNVTSPEDILAVLEAGALSRTTAATNMNQQSSRSHAIFTVNIKQIRAVPVDDDFHYRDDDGVCAVKRANNETELETLQAKFHFVDLAGSERLKRTGATGDRAKEGISINSDLLALGNVISALGGATKGRVGHVPYRDSKLTRLLQDSLGGNSRTLMIACASPNEPDQAETFSTLNYANRAKNIKNRAVVNQIQQGAGGLIDVANFAYSQEEWEAWNNELNMHLSPKFVVPEEDAFAIPLPPLGAPDDIEAIAKARAQFTKQLERFRGFEEAAEQNAKILEAKLKQRLCTADLDRERVLLLEEELNKVKSEMSNQSRENRQLKRKYAALETRVHVYETELENGRQQIERAKRYIDQEREPEKNARRTLVKLAEMFESPIPTTSNVARLCKKFGNDEGDQKENEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT29</accession>
    <name>A0A914HT29_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT29"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3503.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3503.t1"/>
        <property type="gene ID" value="Gr19_v10_g3503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3503.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7535" checksum="D21C07956621B871" modified="2023-02-22" version="1">MAEGDDNNNKKNISRRKIVFVSANALLLYTYTLYSLAAFSPLSSINNVEEHNGTQAQHRRIIAQKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT45</accession>
    <name>A0A914HT45_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT45"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4407.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4407.t2"/>
        <property type="gene ID" value="Gr19_v10_g4407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4407.t2"/>
        </source>
    </evidence>
    <sequence length="537" mass="60829" checksum="AEAAC10867B06309" modified="2023-02-22" version="1">MLFCTTLAVDVPKSTTGDDALLLKLEGVAKQFAEQIGHCQFTFGPLPFPEDIQSPQKRWEATRQEATLTYACCKRPRRRRREAAHFAEENLPTAREGYQELRLLNHRVCLLRLMANLREKAAHTFYFMPGFIGYNEDVAKNMIALYKDMKNQTLIDAVIDGELLLDKTNSTSSSSLHGNLLASDGKTAMYFIIQTWDKSLPECADDSFGHVMIKNGNAMDRTAPTCRPKWELSRNALDECCRENMVYTITMNDSRIIRGKRSFNCFSIRLLKRYKLLDKYAITKTITVKSPGSPKFAFVTAADDAHYPSLRRLLANIKENFGCNQKIIAYDLGTISKNNEWMIEINSVCNLEWRVFDFAQMDEGPVSNLESNAWKIFILAEVFSKFDTFVWLDTSILFDSNNLAKFLKQIPRKIGSVQLPSYSGHGMNFATHPGMYEFLPLFTNYEANKTYELTGNDDPPQFEGDASFLPQTSRDHPRSTQQSHGIDGLFQVNVPLQDISTLDVSTLDISTLDVSTLDISTLDVSTLSFKSCKKGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUY5</accession>
    <name>A0A914HUY5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4906.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4906.t1"/>
        <property type="gene ID" value="Gr19_v10_g4906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12884">
        <property type="entry name" value="SPRY_hnRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035778">
        <property type="entry name" value="SPRY_hnRNP_U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381:SF56">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="962"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="589"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="911"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="949"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="787"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="857"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="911"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="953"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4906.t1"/>
        </source>
    </evidence>
    <sequence length="1428" mass="161554" checksum="E5CDD86FC22CFB4C" modified="2023-02-22" version="1">MNSSYLHTDTNKSMSATRSRRSGITDSGGLNPSTIHLLPMARVKKELEARGLDTKGNGAELAFRLQESVRLAGGYASKFDPSPTTETTPQKTRKRKHLEIEIDENVAEVGEQEAPLPVLVKPFHFTWASAPPTAPRPAKEAMILATEEQLTEKEEMDKQRLEEEEEKRKRSEEEAEEEKKRLKEVEEKRKKKEQAEEDKKKLKEDEEKRKNIEEENKKKLEEAEQHKIKRNEEVEKKKREEEERKRKKGEEGNKKKLEREIERKKKREGEVEKKKKSEEDEEKRKKNREEEMEQQRKKIENEVEKKKKRSEEDEEKRKKRREEEMEQNRKRVVDERKKKEPGKTREHEKEEQLKKESEEQKKVDGQRQQSTASKDPSKMKLSTVPTSTFSSNSVSLDILDSIMDSQQQLLTRKQRKDDEDETEGVQQFKVDFLRRQQRMSTGGKNGASASDIQKRRMSLIFGPPPPPPPPKQQKVPTESPKAPPPAAPPLERPEGSAVVPSTSASSFPLVINLRDPLGLSLVRPERPFPPPPPPPPPPPKRQKVPLLQVPELPKTAPPVAPLQEPEGTVASTSASAVPLVVNLRDPLGLSLVGSDRPFPPPPPPPPPKRQKVPLSFQASESAAPPVAPLQEPEGTVASTSASPVPLVINLRQPLGLSFVGPDRPFPPPPPPPPPKKNVEAVQIVQDVEEEMEETEQNEYGVGKETDQNEDGVGKETDQNENGVGKETDQNKDGVGKETDQNEDGGGKETDQNEDGGGMETDQNEDGEGKEADRNDKEEDTVQLVHDEGEETDQNEDEEGEETDQFEDEEADETDQNEDDEEEDTAQLIEDEEEEDAAQLVEEAEETDQNEDDEEETDQKSAEYRHLLKDPKSLLQKAQDVLRQKFGGNSDANISSSSAHYEQVGLNVEEFKKETDEEDIRQLPDPEQFHGEPVPEDMDDDLFELAAGLPPRNKNKEQEPKPVEEEPLPDAEHVEMDFYNSDLNMKASSANKWLVDPDNGDGFALMWGGVRANWGVLVPEEENQRVEMPPIAFQAKITEFLSLKHLPFDESDPHQIRVGWSLAGTSNMLGEQSNSFAFSSMGNKATNNLFTDFVDPFVVGEVITSVLDVGRAEIRYYKNGQPLGAAFTDIRYETGDVYFPHIATKNCKVMVNFGTEVPEPTEAAQDESGLCLWSMPSDEVPEETEWIGNLDRKLLASSRRPLADKSHCTIISMVGLPGVGKTTWVLQYLKEHPNEDWILLNTDTILQAMTIDGMPRHRVHQGRWDMVMGLTAKALNRSLQMACRRRHNYILDQTNVFREARKRKLTQFQDFQRKCVVIIPSEAEHERRLIRQAREAGGGGQMPAEAMLEMKGQFSIPCTESEPVDDVIFVEPPIERINEAIEQVMRYNQEGRPWVRNFGHQRTRGPESLISDHSGMPAPRFLGVTRIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV54</accession>
    <name>A0A914HV54_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HV54"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4074.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4074.t1"/>
        <property type="gene ID" value="Gr19_v10_g4074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4074.t1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44689" checksum="9C87C537810D72C6" modified="2023-02-22" version="1">MDIFAFCEQFSSIEHTIAYMRNRGLLRQIAPICGRNGCRRRMTQVKNATFVYDGYQWRCPTHKGQKISIRAGSFFENAHFELRKGLMLGYYYRLSSVVRIAVKVVIISGTIAQASVRRILVKSVTEREAGIFEFETLNFRISPFLVKSLNTEAYLTNTMLNLSISTNKTEFPYLVRYPATMALVEFKIKLELVVGVYTADMKMELRSSDGKFIAELIGDDRTLEELGVQDQCIVHVHDNNETNDVPSGDAQTFYAIPEDKYANRKDTARKWKQELLETTSTSTTDGNGREQRVPDKIRPGKRCVVQVRDQSLRDAQIAFVGPTHFGQNPGNTQWVGVIYDEATGKNDGSLDGHRYFCCEAAHGGFVQARAIVKVLDDVEQSANDSNGKQMEIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HV90</accession>
    <name>A0A914HV90_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HV90"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4487.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4487.t2"/>
        <property type="gene ID" value="Gr19_v10_g4487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054179" evidence="2">
        <location>
            <begin position="27"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4487.t2"/>
        </source>
    </evidence>
    <sequence length="408" mass="45319" checksum="D7C9108FC48AAA6A" modified="2023-02-22" version="1">MFARLCAPMTLIGALIVVQLIEYGRSDTEAFREVRPSHECQGRVPKCVCGWAKCAASKGAPASDCCDEGYAFKCCATTTPTFEWKPKTTDQLINELKAKGKQCKSGQYCMCGFVLIRAKLAGLCCYNDTDSCQCCKTELSIPSNHFEEQYTPECQKEMKTAEQRVNYQCKPRCVRSEDWPPSACCAQNYRLQCCDPYGQSPETDPCALRAVLCKADDKTCKKKKDAQGKLHNVRHISNKWTNEETIDCHSEAAVDCVAAKYSKGTTPTTTQSPAKTNGPKRKTGTKMPSTIAANGTDVSAVTVPTASGMPPKRSDDLSLDAMRCTTMNRCYPAILERQMLGTLGKSYQFKSLYTVRRRMTEQVNSNTLQCVHVLGCSTGLFTEFVLDDFFMQKGAFMDEYIKLDNNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXM6</accession>
    <name>A0A914HXM6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXM6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g498.t1">
        <property type="protein sequence ID" value="Gr19_v10_g498.t1"/>
        <property type="gene ID" value="Gr19_v10_g498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150105">
        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06728">
        <property type="entry name" value="PDZ2_ZO1-like_ds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865:SF28">
        <property type="entry name" value="POLYCHAETOID, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="215"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="308"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="578"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="2">
        <location>
            <begin position="899"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g498.t1"/>
        </source>
    </evidence>
    <sequence length="1168" mass="125932" checksum="F14A02114188453A" modified="2023-02-22" version="1">MVNDDNGSCAKESPPVCPADNAGGGVDGGGSSGGENGGGNAKNRPNFGLELSGSKDGSPPSTSKLSFNNVVGYARSRLFPNSDQLAVAGKDPTSSSNSALPQAQSARDTPNKTTKRWTTAGAIGREGSNKSCPVGRRQWTASKGGEESQRLQRESCSLGGSRESVGEERLPEGGGTETVSTIAGGDPSVSRRLSLQQQQKTNNNGTEKEHWQLFAITLQRASQSGFGIAISGGPSQGSAILVSDVIKSGPAFGLLQVGDRIISVNGCPLEQADYASAVAVMKDAQQLNMIVKRRVPVPFVEFEQRTLKFTLSKSRKKDDFGIVLGCKFFIKEILNPKLAEKEPGLKEGDTVLRVNGQTLEGVTLDEASRLLQRSREKLSLVVQRDVRRGAAGSRWPSQTTVYERLGSVQATPRQSPTPVQYVQNAAEGQFVAAGAFGRKCSSGSEGYLPGGFKRYSDPNTVSGNYTPPAQFPPQSQPSQNSCQQSPYLHQQRLAVHAASTPPARPQSQTPSSVHSLNNTAVHHHQQQPFIPPTAATNNSEQQKLLADHQRMFAFQQQQFNPNPPISTFQPRKPHEMHSITFHKGSSGLGIRVIGGNQSGIFVSAVQDNSPADQNGIRVGDRIHAVNGLSMVGVTREEAFEFLLSTGEQPICMTVEHLSEEYSQVKAGKFGDNFYVRTHFAHKPERGGVGGRHVQAVQQPELAFLSGDIFHVTDTLFGGSPGYWQVAKVYSAADAEPKGGVTEPGAGVIPHAKAAETLLARQRQAEKANGGGTESPPQMGGGGGTLGRNLFRKKLSLSSRKFFGGDHSVAEDVLSAGSGTGNYASELLAPAYERVALKRPAFHRPVVLYGPLADVARQLLLSKFPLRFGAPFPHSPSVNNAVDPLSASTSSDSPQRSIPLAAVDAVMAAQKHCVMSVSAASVERLQLAQYAPIVILIDVESRSRVRELRSKAGANTNSSRKLLEQSQRIKKQHQHMLTATLDASKEDQWFDALRQLIFHLQERRVWMPEFSPECPLDDLLLFPIQQPGETPTSDSAGPAHRMPKGEAGPFLVPNPMYTLNLKQQHFGGVPLPIHHQMSSSIGSESEHQHRPRQQPLYCSNSRQSEPPPPFHALPSGSARNSPFPPPEQQQHSVYNHSQQIRSSPMEAKSQLLAQLATELGSPVQQQQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY44</accession>
    <name>A0A914HY44_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5550.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5550.t2"/>
        <property type="gene ID" value="Gr19_v10_g5550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase central" evidence="11">
        <location>
            <begin position="1499"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5550.t2"/>
        </source>
    </evidence>
    <sequence length="1802" mass="210970" checksum="699A6D5651F39456" modified="2023-02-22" version="1">MEQHTYTEQPQRQNFQYYPNPPPPVVYERRYAERDSGPRCVPCCCCFPCIPIPLCFDCNFPPTNILYGIDRRNLDNEYCRLLFDAPLDHCAQMDIGTRLGALLVYESIETDLAIIDFRLGQIFERNKFLAAYNLNKSTIRTKFDELNTKIWNKKVGEKRFGMDNVCRLWSFGLEVTKLNDFLNRNQTLAEKEMNKLATLLKLNEKMLNGRGEIDQIVRMKQKMNRYLMEYKYIGMLELHNPLTMAFDIICDSILKTAFRGIIMFDGIMSDEMALQNKKWIEISLLCGKIIDYFMQQIQNAKAEGANNEAKIAKIGNHWKLFARLLGLFKNNSEFNDQKLLLNKLDTLFDYLRGQFGEHKLSFKYKRMVERLELCFLELYEQNSEFRECLRNNLSSMAVLKELFEIAEANEQIISEQLWAVLVKNLSGEKEIIVPLKEKVDDQMPIPTLLECPDKNIPLEKLEQVDDEEAKKDDEAFSLMFLYKEAIINAGDNIDFHLHLIELHELILLPEEDEFRWSESDCADEIVQNKLISAFLKDRMAPTQFHLAAWDAVFRRFGQIRHFFCYGTDQIEVAIVKENFRYTFGELLLDRLELVHPKIMRFESPAYSHFLLLLLQQLSDKTDSVPAELAEARKYAPLLLLDLQFYEQNLEGDLAERKAMGEAIQSAKQNFYRYLIKMQRSKKHSIRNAFCVLFCSHGLLKRKMALNLKWNLIYAECEEEANVKETIAVQRHRMRGLTLNFLSQTIANKLFALPERIKAIRGGRTRLLKMLYDPDISFEQNEEKIANLWEAMHLDLSTIDYGDSELLISHYEEALLTDDDMIRIEGKMKAEICVFFNWINSQIFSKNSFLSAIRNNGRKYCDLSLQIIDDFYDQIFDERSAEVEQNEHILVDLIFEIKTQLEKILAGHSMKSSELELLKEWQKWHLNRLMDRKAGKSFVKAKHWNEYGPWMRQLHGIMFVQLLKMDKNFAQKLKNEFETSLMKKNYLIELLDIEKFVAVHIRTEEAAHSAERRHSKMPAFPALQQFGEENCENCNNWGVVAAHSLLKLLDIGILANEIWHSVEAIKALNESKCDERWANIEMELAHLTEKEFVVENAQNSNSEIEFCQQIRHQLHLRKFSMALFHSGRFWSNLSEIRRKQIVSTLFRVEDEKTIELFVGKVEKYLILIKKLNEQRNLDESLFNEYKNGLNKFVSKKAKKKLHSDKSTLPHEFAKNWQEINFVENSNRKSKQIIQIKNYLMANGYFSEAERHKNERIVSELTRIVEEWCPDAIVQFPMSLLGNEKLEPICILPEEIDRELIFGKLNFNFEMSEMGAKCEDKSLYCSLLMRSEFKSVQKIVKELTTLPTLKFNFMDVPIEMAFILVPKVKLANSGEPIGLRTYEKFAKYFAENIEHLLNADRYDEGIHMDEVKLQNIIRKQLEKSKSFNDKFELDKVLGELKQLTSTKEAALKQRQIVAEQKVMLLALSRNFISEKIVFEILSPDTKLEENSRGINKNERLRVALAYLELWAKNNFIHGRNMGYLDTPMLLIMMAKVFLMFPEASIPFLIEKYFLFYSKWKWPMPVQLAQIDDKRIGEFLSWGPGREWFTKRQFLAKNLRKTIGQALAMPIISPLFPEQNEAAQINLSTAKVIQNELKNAFIKIRSTDKGHGIIKPIAGNCKRFSEKYEHFVTFTCGGTKFNVEKFCHFVGKRLRHELLYFVENSLANWVRFCHVHPTRVPVEQSSDEQQQQIGGSNNNLHKNLWLVGLKLHKQKVQNKFVDELIDKLAEISAKIKKDFEGDLFYNVQLHSEYVEKSKLAKWISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYV3</accession>
    <name>A0A914HYV3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5298.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5298.t1"/>
        <property type="gene ID" value="Gr19_v10_g5298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5298.t1"/>
        </source>
    </evidence>
    <sequence length="573" mass="63819" checksum="981DCCD8336B00EA" modified="2023-02-22" version="1">MVHVVFDTSNVEYDDYVQTGGGAAEAGEDLTYFKGSSPYQRGYGIQRGAGVGDVFRGLWRFFLPILRRVGTTVGAEALNTGQRVLERVANEGAPLKETLYNEGKRGIDTVLEKGGLPKQFETHTLGHLWTLLKMAFHKIDNDSVNSITNALDFFHVPPTNVSVSSSKVFELLPSNPLTDTPYHFKLHSSQNFIDLSKCYLFTEFRIRKENASGLLVNLDASDNLVCPIQMIGQTFIRNIRMSINGREIFNTNSLMAYKTYFSHELSYSSTAKDSHLNAAGYYGDKDETLEQGDGCAARRDLFAGSKTAQFIAKIDADLFNQPLYLINFCELDVEILPNDSNFLIVAPSAGATAPRYHFEVVGLKMYVKKVSLMDGLALDIARKLEVKPARYAVRKTMMKSLFISQGRFEFTANLFMDQIPRRIIMGLVSNSDYVGDAKRSPFNFQPFNVREISIIANGRSYPQAPYDLDYSKGKYVRAFNDMNEAVGFCNTTESNGITFKQYGKTHCMYVFNMTSSGDDQAGLFDLIKNGTTAVSVKFSQSVPVGGIMLVVMGECDALVMLDKNRTISTDTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ37</accession>
    <name>A0A914HZ37_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g5358.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5358.t1"/>
        <property type="gene ID" value="Gr19_v10_g5358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37409:SF5">
        <property type="entry name" value="CELL WALL PROTEIN AWA1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37409">
        <property type="entry name" value="RIKEN CDNA D130052B06 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="837"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="901"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1098"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1286"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1304"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1322"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5358.t1"/>
        </source>
    </evidence>
    <sequence length="1394" mass="160055" checksum="3FEFF3235D0C9490" modified="2023-02-22" version="1">MPEQNSEDWLEQFHKFEEMLKNEFGQIGESAKLRQKNLLVGYGNCLLESYIESEQFREKFNWKTETRKRLRKIFEGTERTIDINLLDDFWSLLDASSSPSPSSSTTALNIKGAVIKSNSVNAVDVINGALKHLEKIREELELGNYEAYIRLIRKLKGNEIDVDTFFGSVVILFRDFPELLEQLNHFLPKGNQLWIPGKSFAALSTNAIPESSQHFFTSKTLKKGIECPSKSEDLTDADAFERSKDPEAYALSLSVATLLRNIQKEFPPSKVAMAFLLQKELKLASAVWYFKEAVRNLFAFVTSMGQKSAKFASEFEKVKKTGEHLVNSNPGGGAEELCHLYIFAHKLATNLVLAAESDQWRKHLLWSVDKQFLFMLPSSFGDLDCSEADNILKIAQKFDELECIQPIFILTFSSLIRRFKLFRNLFCHGFDGLAISVVKERLLWIVQEKVVNELETEFPEIMHYEIMINAMYLTKLLTQLTFKSGTAIAEEYEARISTTFLLKIVTEFEINISTECKLPPKICEALLGTIAEVKNAFYEKVGDIGEKMIVEWEPKECNSEKGIKKALEGQREVLANVHFAFLRNAMAEKDWVIGAIRERPGASTRIRTLIIDENLYDQLTDSIGEQLTNPEVFDDDKLFECHYRNALLYADSLIRTEGTMRADITTEVKHFEAENELLKQIFVEVKTFLQVNLKVRKVKSEKQLGSEWTQRMSRRYRDKLTELVENKERSNESGHILVDDDLQIPKEELDKIDDWLNILHFAALEGLIRGDGTFEKELRNAFGHSKAVTDRLIDFLDSEMKAFDLLKLLNLSPDVLEKVLPASVKFEIEKNAFVMPMPTIQSDGGEGEGEEASKKPKKKRKAKKEKMQNKTPIGGEEKGTVTEQKKRDKAIEPSKQDTVNEDNKEDTVNEQNKEDTINEQNKDGTVNEHKQDTVNEQNKEDTINEQNKEDTINEQNKDGTVNEQNKDGTVNEDNKKDTVNEQNKQDTVNEDNKKDTVNEQNKQDTVNEDNKEDPVNEQNKEDTVNEDNKEDPVNEQNKEDTVNEDNKEDPVNEQNKEDTVNEDNKEDPVNEQNKEDTVNEDNKKDTVNEQNKQDTVNEDNKEDTVNDKQDTVNEDNKEDTVNEQNKEDTVNEDNKEDPVNEQNNEDTVNEDNKKDPVNEQNKEDTVNEDNKEDTVNEQNKEDTINEQNKDGTVNEQNKDGTVNEDNKKDTVNEQNKEDTVNEDNKEDPVNEQNKEDTVNEDNKEDPVNEQNKEDTVNEDNKEDTVNEQNKEDTINEQNKDGTVNEQNKEDTINEQNKDGTVNEQNKEDTINEQNKDGTVNEQNKEDTINEQNKDGTVNEPQVEELATEVERVKLSDFGDDRFLFAKYRLLLGALLGERRPNDSTDIERSNFFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ77</accession>
    <name>A0A914HZ77_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ77"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5381.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5381.t1"/>
        <property type="gene ID" value="Gr19_v10_g5381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5381.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35386" checksum="E80DAF13F294B832" modified="2023-02-22" version="1">MEERPNTFSTGAICPFANSSLGTQQRMLMSFSQCVVTSFTAIIALNMAINNTFKLRPKRKGQGQLLRLPSPANPCLLKCKDDYMMSTDHSLPAPNWRLDSAIGSPLHALVETATDANAIERIDFECSYHAQFLSCLEKCGTSPATQILTEGQQTLKTVCQSFKKDKEFVGFVLPCLARNGAKIGKSCQLHWSLLEKDVFEALQSKIETETKQNGQHLDDGIRNLCRGLNSYADCHLRTVAQLCHRRALSFFVRLNANSSAALLRLLVVWAGFDLHSAAQKWPECTQWNLDVPLSDGGQKMPLFNQIIVFCLFFILFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZB3</accession>
    <name>A0A914HZB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6060.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6060.t1"/>
        <property type="gene ID" value="Gr19_v10_g6060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6060.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12229" checksum="519E5B448AA09180" modified="2023-02-22" version="1">MFRLFHGSSSYYGIRKPSSSEGFDGTPYLPNQLQSTGCNFFSSTPQSSNFNSGNPASSYYPFNQSAQLNSSTNFVPSEAGTHSTNFFGEIRKTMREIFIRWSGRKNRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZT5</accession>
    <name>A0A914HZT5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine deaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZT5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g530.t2">
        <property type="protein sequence ID" value="Gr19_v10_g530.t2"/>
        <property type="gene ID" value="Gr19_v10_g530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF18">
        <property type="entry name" value="THREONINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="107"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g530.t2"/>
        </source>
    </evidence>
    <sequence length="494" mass="53550" checksum="09BF50AB1CE4A5C4" modified="2023-02-22" version="1">MFFLSYHSCVEHGKVYKQFWAADVNVLLLIGQKRDCHSSNSENTKPSMEELNEASIAVPDCLRAEGSDECAIRRIPSALCSFVDPFCDPKKPVKTTFSDISSAAFNIRDGINRTPTIKSDAFSSMFDVELFFKQEFLQVTGSFKERGARFALMRLTKEQRQIGVIAASAGNHALALAYHGHQLGIPVTVVMPKFAPLMKISCCESYNAKVILHGLHIQEAKIFAYELAKHENIKYINGFDNPDVIAGQGTIGLEILDQVSNVDAIVVPVGGGGLIAGVALAVKTLKPQVLVIGVESEMCPSFKNAVEQRDEPLHPESSLADGLAVPTVGDNAVFMAEGLIDDLVTVCEESIALAILRLLEVQKAVVEGAGAVGLAAFISGKLDYLRGKRVVSILTGGNIDTTVLGRTIERGLAVDGRLIKFDIVVSDRPGGMAELTSEIGKTGASIKDLFHERAWLAANVYSELITHLGKKYKQISFPGLLSHNLPRKIGIRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0S4</accession>
    <name>A0A914I0S4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0S4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6242.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6242.t1"/>
        <property type="gene ID" value="Gr19_v10_g6242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6242.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7604" checksum="D3D71F0F38CFCE10" modified="2023-02-22" version="1">MSIPGQIVLPHRLSSVPNWRLLRRHQQQKRGEAIRSACAGLFRCQGVSSNHQPILGPRHPVGIGVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1A2</accession>
    <name>A0A914I1A2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1A2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5960.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5960.t1"/>
        <property type="gene ID" value="Gr19_v10_g5960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5960.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16376" checksum="C74BDD3A1CD9D9F1" modified="2023-02-22" version="1">MSITKSTDRTAKLDKLNQIQLIRILLSQSLINLDKFNQIQLISLDKLNPIQLISLDKLNLIQMIIMLLTQSLITLDKLNSIQLIKIHLSQWLITSDKLNPIQLISLDKLNPIQLIRILLSQSLINLIMLKMRENVKLSTNSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1P1</accession>
    <name>A0A914I1P1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1P1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6490.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6490.t1"/>
        <property type="gene ID" value="Gr19_v10_g6490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858">
        <property type="entry name" value="OS05G0521000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6490.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39575" checksum="4F512A906DB04DE2" modified="2023-02-22" version="1">MADVSDEAAFDFDLDELFNDTIVIIGELLNDWRQKVCCKWAVLIIAILAIGGLLMFQFQEMCTKIEQQQAEPLERQNQIQFQFLSQQIEQQTHLLKSLVVNEQYSDNFWQFFAISTLAIALLASKAKRWRPLVLSLLKWAMHKFWIYPILITLVVIMMAFLSDRKFQFQTMNTKIKQQKETFERQHQILSEELKVAQQTKFSLEDERGELRQIEDAQQSIQFQFLSQQIEQQTHILKILMVNEQYSRNFWQFFAISTLAIALFASKVLKFAVNKTPIELSCINRCVICFCQQREYAFIPCYHFCVCEPCSIEIIAKDAPICPMCRRQANGTIRIYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5N1</accession>
    <name>A0A914I5N1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5N1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g774.t1">
        <property type="protein sequence ID" value="Gr19_v10_g774.t1"/>
        <property type="gene ID" value="Gr19_v10_g774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022559">
        <property type="entry name" value="SUP-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34149:SF9">
        <property type="entry name" value="PROTEIN CBG09996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34149">
        <property type="entry name" value="PROTEIN CBG11905-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10853">
        <property type="entry name" value="DUF2650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037771319" evidence="3">
        <location>
            <begin position="25"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g774.t1"/>
        </source>
    </evidence>
    <sequence length="511" mass="57207" checksum="D62C51F3C8E069CF" modified="2023-02-22" version="1">MPMPLLCLFIILPILLLTSSSCLAVNWAFLSDQSQCQVGCLNGGVCAFQREDPAQQKCICLIGIWEGDRCERNVAGPDDATMESKGGDGKMKDEFEEEEWPPDEEESLEESAEEGELKIKSDDKKEKREQNGRWMKEAEGEGEEEELMDEMRKVPENPAKYADDWSEEMGKMPEEEADEEKNGPLPTRVLGKKPDNEREGRMRVSEGKKSSDEKKMLDGDGKSRLGKSTSPNVPRQYLETNTIELGEHFEAPRRGESSAVTIARGPKDGNEEEVFEEPLRKEAGSKKVSKTTTIGRRRKLKMDEWSGRGEGRGGRGEEKSGGRREEGEGRGEERRGQREEGGGSWMCRMGMDSDDSGDRSGCLFLLIWERGGRGDNERSGLKEIIVTMQFYSPFSSFLNCRRSPKFPFRKCLFLLQLTLMLMAVDGGEVREGLEKVGDRVSGAVNELAEVKSGQLWCPIPAAGTKCPSSSPFHYYRCCGPLNNECCLSLQTAALCILQVFIQSHFGVFFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5Z6</accession>
    <name>A0A914I5Z6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5Z6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7087.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7087.t1"/>
        <property type="gene ID" value="Gr19_v10_g7087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7087.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24405" checksum="E090AC46FB1216DD" modified="2023-02-22" version="1">MASGRYWTHRGQFNVTCLNGRIKVLNCVTEQGVQLALGTKQFLEDGVRYSCQLNMDREQREKVQQQRNATADHFVPECDQQLNNGGHANTRGEFVRDGFVVDCASNNILGCMDVNGDLVKSGHFYVLSSWRLRKCEVYGRGRWAKSERKGCFNGTHWDDPDDGTLHVPVGRIWPTGPFELRCGDDGLHVYKCIVDGRRIHTGTAWIDGDNVLNVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6D4</accession>
    <name>A0A914I6D4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6D4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7317.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7317.t2"/>
        <property type="gene ID" value="Gr19_v10_g7317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7317.t2"/>
        </source>
    </evidence>
    <sequence length="206" mass="22307" checksum="03D5A610FE23407E" modified="2023-02-22" version="1">MGEFGAGAIGAAGGPPEGMPPPPLLQEVLQHGTIGNFLGSSLEGVESGFIRCVYTAKNRSTNTVTLLCEKMEGCCLGGCCPKDQFWMTGLMILLVFVLLLLCVGTIVMLICYQRSKVQQRRAEKELYEATTARRAPGSEVAQSGGGIYSRPINRNITAWLKQYQQQWDMAIIATAAAAAAWQLGASETTKCKPHLNCFLFSPNLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6Q8</accession>
    <name>A0A914I6Q8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6Q8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7137.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7137.t1"/>
        <property type="gene ID" value="Gr19_v10_g7137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="5">
        <location>
            <begin position="195"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7137.t1"/>
        </source>
    </evidence>
    <sequence length="507" mass="58365" checksum="7B81424B64F47543" modified="2023-02-22" version="1">MAGQIRFAETKSSRGKLLLSHGGYEYTFEALSKIDDGSEYWRCPIRPPYCPGRACVYTRWEVDADGTQYKVGRITGEHNHAPVFGGRMVREACERIRVEARSDFPTTSRNIVRAARSDLPAEVRIHSAPSPADMRRTFNYQKRKHQQEANLIANCIPDRLQNRVIYDQNIHGERMIIFCSHFALETLSRYRQEVAVDGTFESCPRGFSQLYTMSVVIDHCAVPVVYGLLPNKTFATYTRFFEAIRAAVAYDWFPLRIMSDFEAGAVNAAGNVFPNSTRTGCLFHFGQSVWRRIQRLPNLLTRYRDDEYVRTSMRSMQALAFVPPQFVYNYFCIVMSTLEPTPELQEFILYFVNTWLGPRQIIQNEEILEEDAGGAADNWIRGQIEALNLALTDALFPIELWNVMERVNEGLGRTNNSVEGWHSAWNVHLKGNQRASSFARKMVEEDETWQHIVTDFQAAPADGIKGPYNTRKAQYIRQDRNLEALVADFQNRDPLEFLRSCAYHLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I736</accession>
    <name>A0A914I736_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I736"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8111.t3">
        <property type="protein sequence ID" value="Gr19_v10_g8111.t3"/>
        <property type="gene ID" value="Gr19_v10_g8111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8111.t3"/>
        </source>
    </evidence>
    <sequence length="631" mass="69681" checksum="BFC771533621F8FE" modified="2023-02-22" version="1">MINRTIFVLLAMVGGRAKRAQRSAEGGKSVICAHQIIKPTNSLKVEIGEHFTHRWSCSEEYGPNRYVLFVRNCEQIERNGKRIILTDKFGCPSEGVPAGHFSLNYSDSTRHNANNSSRKILTVFGHSQLFSSPVGSLFRIECILLLVPKVGGANATELPNCSRNSSTAGRENVLSKLLTPTMANQKRFIDMVETSVSSQWIRVGDGHKDRPALSKHFGTFLEKLSSGSKEHREEAPNMALNPFLERAYSIFATSVPTVPSIPPTAITAPPTRSTVPNAEPVTPTAPATVPPMAQFTPSTVSDTEGAIPSSSPKEPATPSFSSSLPLIGIRRDGSSSSPPNLGNLNTPSENKHPKFESHHYVRQQNEQISQETSQNSFYVNVSCPFFHNASTPSPSRHCSWSMLNTALLTWSIFSTLHWLCLLGGKLRSSVIVHRRLTISPKQKMAAAKMNAMRRKMMRTKHCGGFKHRKSLIECPDNGTTDRKSPSERRRAQQKALRTVRQRHLLHRTVIGAMPPLGFDQPESVHQLSLSAATHRRQNQINDRRRRMVSNLGRIQEEEGEGKRGCHRQEKSGAGILDGRSEGRAKSGGGRAVDDGRAENGEQIAVEQITTPSIGNALQMITARHFRSCFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7R6</accession>
    <name>A0A914I7R6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7R6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8071.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8071.t1"/>
        <property type="gene ID" value="Gr19_v10_g8071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038032208" evidence="1">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8071.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13408" checksum="63B189F8563D5A3F" modified="2023-02-22" version="1">MYPNIQALILIIYIARTHATTQKSTYSLRIRERTKALDVLYKITDKCAKLEEFLGDSVLYALTKMTSDPTLQKILHVNADGLYLHIFSKGERLFFLRLKEEEKKIEEVYGTPRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7U8</accession>
    <name>A0A914I7U8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7U8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6471.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6471.t1"/>
        <property type="gene ID" value="Gr19_v10_g6471"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g8093.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8093.t1"/>
        <property type="gene ID" value="Gr19_v10_g8093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF240">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041151068" evidence="3">
        <location>
            <begin position="23"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6471.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8093.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="26040" checksum="89C1AB4310FEACFE" modified="2023-02-22" version="1">MARIVLLLCVLVGLFHIAVVWSSEQLPKIVEEENALKKPGRVSVVESLKLCKVDAAVHPELASNFEVRAYAVWSSEQLPKIVKEENAVKKVGHSQKLSNVDVAVHPELASNFEVRAYPTLKLFKNGKPAEHRGGRVAASSLESADSRDDLEEANSWKCNAVLLALIWGALFITSPSSVVQCGRSGGGGGRGKGSGSSSTSGGRGGGGSSGGGSRQRGGGSGRGGRGGAGRGGRGGGRRVNNANEEEEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9A6</accession>
    <name>A0A914I9A6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9A6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7812.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7812.t1"/>
        <property type="gene ID" value="Gr19_v10_g7812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7812.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28927" checksum="6D363FB107B5FC63" modified="2023-02-22" version="1">MAIASLAGSFCLMTGHQRTPYISSGISHQMPFQHRPHLLNFFPLSKPNPQLLSQPIPSWPPFCTCLYPSSCWHCSLAPNSSPESKFDKVASDVARANSVSVVSSECTTTNEFIAARKQLHGGESVIERRAHKCCWLLSGGKRCQRRCYDQLRAPSIPPTQKFTFTDECPSLTLNGTVPISELNCVTDREAVVHSCFSACLHWWENNRATAGQQVQRFDPSRDCPALVELSKSESCMIPEELLELARRDEVKGTTNGKKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9B6</accession>
    <name>A0A914I9B6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9B6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8473.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8473.t1"/>
        <property type="gene ID" value="Gr19_v10_g8473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8473.t1"/>
        </source>
    </evidence>
    <sequence length="485" mass="52703" checksum="464CB4C05600E498" modified="2023-02-22" version="1">MHRIKESAERARRCRHLNFLISETFDLAEKHCEAALGTAHTPFVMVVKDNFAVRGVRMTCASKMLREFVPPYTATTVQRLLKNGGCLLGKSNMDEFAMGSTSSTGCFGPVLHAMYATDADADGGMAGGAGGVDDFRIAGGSSGGCAVAVATGVADVAIGSDTGGSVRYPAALNGVYGFKPSYGRLSRHGLVPLNNALDTPSIFARTAEQCRTYFEILRGHDPMDATSLPDDVVADKQPTKRAEAALDDGTLIIGIPEFDHSHFVSDDALRVWHAAIEQLERAVGARTRAVRMPNWEACIQCYATLTDLDVASNMARYDGIQFGHNDAIDDGTSSFTEQITASRTAMLGQNVKRRIFAGTFYGLQQNFERFVGQAARVRRLIQRDFQRAFEQCDVLLTPCSRHSAPLLSETVRRSRTEQHRMDDFFLIPANLCGVPAISVPFAHCAEGRPLGVQLIGPYLADDFLLQVAALLVPLPTDHTANLHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Y1</accession>
    <name>A0A914I9Y1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9Y1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8255.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8255.t1"/>
        <property type="gene ID" value="Gr19_v10_g8255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8255.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="36641" checksum="8CD80446E67428BC" modified="2023-02-22" version="1">MNTLTKGTAPRIDGIGTQIPQIPFIEIKVTDTAAAAAAEAAAFKGQKATAPEGSAFGSKGNKERPKNDKKHRRSKSGGFLATNARDGGGVHWDNLPSQFLRTGPLAKEFAEEKRCKKSHNVVRPIIASADVVALKRRDKNGGTAVALTDSRPWPPQMWPTGEGDAVNRNDAIQPSPPAKSQKNLTKVKRSYSVHRHDSLMTEEMPVFTESDRRLRKSVPSSPQTILALAGLFVCGLILMISGLIVLCTTWKSARTLKNGWHYQVAGFLMLFLGFTGVGICAILQRKNIAKLAEDTSKDLFNVAANAAASEAKRASEERALAGGSRKLNRMLSQVPSTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA84</accession>
    <name>A0A914IA84_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA84"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8041.t3">
        <property type="protein sequence ID" value="Gr19_v10_g8041.t3"/>
        <property type="gene ID" value="Gr19_v10_g8041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8041.t3"/>
        </source>
    </evidence>
    <sequence length="142" mass="15887" checksum="37BA0AB8A90A3532" modified="2023-02-22" version="1">MTEAVQGRNTVNACKNDATARLYDQRPGVLLTASCQPNWERPEQHCLPFRKMKSCQWAILQVFCQLPASPSLSVVSSSVAGEYSTLRRNFVEQAGFEANVPRIMVIPRGRNGFDSDRGSQLRCQIDLSSSWTNLHKSKNISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAR0</accession>
    <name>A0A914IAR0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8858.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8858.t1"/>
        <property type="gene ID" value="Gr19_v10_g8858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF217">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="13">
        <location>
            <begin position="340"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="681"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="902"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="961"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1051"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1216"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1314"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1119"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1150"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1189"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1220"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1324"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1357"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8858.t1"/>
        </source>
    </evidence>
    <sequence length="1539" mass="171654" checksum="4DB9DE894D968C7D" modified="2023-02-22" version="1">MPFVTPSTSAKGHFGISSRRASCSDVDQHSSRKCSPAKNYAVDNHNEPSRPRGELKGLQDSLSQYFTPNEVRRSRVTTNRLATEQPLEILVEPGNVAFREHRTNSLCSSKSGNSTISPKSPHRRDRLEDALSPYFTPNPNKRRTHREGEYLQLSKGEDHSSTNLPKEAELDPINCTTSSGFDDRQEEKNDLESHSALSTAKLSGRISRCSHLNNRSISDNRLQKRVAEYKKKRENVGARKSAQLIRRAFKGKCGHGQLRMKMSQPVSSTLKSCNASTSLKNSIKSYFLPIKKVPSAQSSENKIIDFSVDIDEEDRLLFEEARQAIQKDLDYTNNALKNNEEKAFPQRIQINCYEIDTWYSSPYPQEYSCLPVLHICDSCLLYVSVPESHYKKCKRIFPPGIEIYREGHLSVFEVDGNLARVFCRNLCLLAKLFIDHKTLYFDVEPFLFYVLTLHDETGCHFVGYFSKEKYSCQKYNLACIVTLPCYQGMGFGRFLIEFSYLLSRRENLIGSPERPLSELGKITYHSYWLSVIYEFLYKTFLLTPNGTSKLNQISLEDISKATGVTVSDIAETLAENRLLSNKDATSSLILEENVIRAYCERSKSKKRYVLDETKLKWSPKVYTPSKDFRFRSPVLSVNSAVNSPVKKKALEDEKIEAVQPFKNKNKKTMARRNLFNSEKVEKCAPQKAAAGKIGRKKMPNGKGFPEESSNCLTNTEEEEADGEEEAPFTRKNRKKASCKETIEKKVNRREPSTDEDEEKSPGASSRLRQSTSNGTFNGETVDLQNNPRGSSMKKCVVSNPNKNLKLSEVTDICSKKNEAEEKSTRKSKKKWTSESESDSATSVTEKTSKKRKVWRRSRIFEKQQRKLSRCPIPCNSSSSPSTSASSFVERFEKRRIEVEENLANSFSSKRQKKIGQQQQEDSPNDDEDDRSYCCSSTSPQPIGDRLPILKTSIREHDLMINMGGEPDTVNMGGEPYDEAENAANTSSFSAEDEDEEPPFVVIDASQRQIKQQRSQAEEIVTFGKVQVVGGVEAMQISESFHPLANRTLKVPSVHGEPHKSSCSPSDAATVEMPALDAAEKHASSPEGSASRFGEELSGTTMLMEDDAPPMLSPQAANMTSNEPSTTTASNNNNADGDNVKIDEQRYEIEPTSTSAEELHKISNSAYKNTTSSSVSSLDISDERERKKNTQPTKEGTDVQNRNNVTRMMAGENRAICSTTTDKDPGQHESVETERESSSHGLPYIDQNISAAAVVQHTGTSIISPPPLEGHQIVGRQPTTQLNYTNVQQIDSLAAFNGVLYNQQQNYAVTQPVVQAQHPSTTQPKFKEKQSKKPKEKLSKGTSPDKTQKSIVPKHYQPNPSNLPSTSAISQPMTPTSFPPQWLNNAQQMAQHFAQYYQHQYYGATSARPADVASTMTAATAHMSMGYAAAPYFYNQWHQAWQMSAAAAGAAKFPGTAAGYPTGYEEFFNGMAMVGSANATMAGVSSSSVLTPTTPVVPSSTSVYPWPAPMFAAAAQMRHPNPASTTVSHQHFYPPSHPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB43</accession>
    <name>A0A914IB43_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB43"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9204.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9204.t1"/>
        <property type="gene ID" value="Gr19_v10_g9204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9204.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10045" checksum="F7D9BB6BF4306E27" modified="2023-02-22" version="1">MTKIALQELGWEVLPHPPYSPDVAPSDYHLFRSLSNALSGVTLENAAALQNWLDEFFASKPPAFYKRGIEKLPGRWEEIVNNAGEYIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBR8</accession>
    <name>A0A914IBR8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBR8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9138.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9138.t1"/>
        <property type="gene ID" value="Gr19_v10_g9138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016133">
        <property type="entry name" value="Insect_cyst_antifreeze_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51156">
        <property type="entry name" value="Insect cysteine-rich antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9138.t1"/>
        </source>
    </evidence>
    <sequence length="784" mass="86670" checksum="F72B0DB14DC8145F" modified="2023-02-22" version="1">MPAKANAVGIHLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPSNTMFDAKRLIGRTFDDPAVQAGMKHWPFKGEDKTFFPEEVSSMVLTKMKETAEAFLGQTVKDAVVSVPAYFNDSQRQATMDAGLIAGLNVRRIINEPSAAAIAYGLDMKGQDERHVLIFDLGGLNSTAGDTHLGGEDFDNRMVNHFVAAFKRKHKKDLSSNLRALRHLRTACERAKRTLSESTQASIEIDSLFDGIDYYTNVTRARFEELCADLFRFTLDPVEKALRDAKMDKSEIHDIVLVGGSTRIPMVQKLLSDFFSGKALAKSINPDEAVACGAAVYAAFFSDDKSEYVQDLFLLDVVPLSLSIETAGGVRKSFDNPSALPINSSNSSSSSSVLNTLVKRNTTIPTKTSQMFTTYSDNQPGVLIRVYEGERLMAKDNNLLGKFELSGIPPAPRGAPQIEVTFDVDTNGILDVSAQDKSTGKQNKITKGRLSKDEIERMVQEAEKFSKEDDQRDRVSAKNALESYCFNIKQAMDDDKKKVLDKCQEVLSWLDGNQGAEKKEFEHQRKELEAVCYPIVTKLYQSAGGGMPGGHEFLWADQLLWADQLLWADQFLWADRLYGLISCYGQINCYGLIKCYGLINSYGLINCYGLINCYGLINSYGLINCYGLINCYGLINCYGLISCYGLINFFGLINSYGLINCFGLISGYGLIKCYGLINFFGLINCYGLINCYGLINSYGLINCYGLINCYGLINSYGLISCYGLINCYGLINFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBS6</accession>
    <name>A0A914IBS6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-terminal methionine N(alpha)-acetyltransferase NatE</fullName>
            <ecNumber evidence="3">2.3.1.258</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50564"/>
            <dbReference type="Rhea" id="RHEA-COMP:12726"/>
            <dbReference type="Rhea" id="RHEA-COMP:12727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133398"/>
            <dbReference type="ChEBI" id="CHEBI:133399"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50580"/>
            <dbReference type="Rhea" id="RHEA-COMP:12734"/>
            <dbReference type="Rhea" id="RHEA-COMP:12735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133406"/>
            <dbReference type="ChEBI" id="CHEBI:133407"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50568"/>
            <dbReference type="Rhea" id="RHEA-COMP:12728"/>
            <dbReference type="Rhea" id="RHEA-COMP:12729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133400"/>
            <dbReference type="ChEBI" id="CHEBI:133401"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50576"/>
            <dbReference type="Rhea" id="RHEA-COMP:12732"/>
            <dbReference type="Rhea" id="RHEA-COMP:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133404"/>
            <dbReference type="ChEBI" id="CHEBI:133405"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50572"/>
            <dbReference type="Rhea" id="RHEA-COMP:12730"/>
            <dbReference type="Rhea" id="RHEA-COMP:12731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133402"/>
            <dbReference type="ChEBI" id="CHEBI:133403"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.258" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914IBS6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8748.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8748.t1"/>
        <property type="gene ID" value="Gr19_v10_g8748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000006">
        <property type="entry name" value="Putative n-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8748.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22452" checksum="1DCA12EA7A818B85" modified="2023-02-22" version="1">MVNSEKICQEFREKCNVESTVRCSGRCDIELGEVTKHNLMQLKRLNLSVFPVFYNDKFYKEVVNTGELAKLAYFNDIIVGGVCCRAEVVDGVKKLYIMTLGTLAPYRRYGVGTLLLKHILYLCQKDSQIKCVYLHVQTNNESALSFYRHFGFEVTGRVEKYYRKIEPDDALVLEKPTNHSIESGSSYWFFITISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID30</accession>
    <name>A0A914ID30_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromo shadow domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ID30"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9488.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9488.t1"/>
        <property type="gene ID" value="Gr19_v10_g9488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00034">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo shadow" evidence="5">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9488.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28684" checksum="283B0A61D4C284B0" modified="2023-02-22" version="1">MDKSGTFTKCTEEKEHSEALLQDKQLLIGLGEKLKLLQSMMGHDEQEKKALRAENVRLVSDNVELQGQLHEQQALSVRLQETVDDLQKQIIEIKIESLHCPELISEFEATHGYVETKSSKMAGRMNQKKGAKKRGATDKGANKGAKKRGATDKGADKGAKKRGATDKGADKGAKKQGATDATPTFVTKERYHIEEHGAVPDRIIGLMKHEESGNMMVLLTYTDNQEATEFVPTKLLRKKESTAKMILDFYEKRVEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE21</accession>
    <name>A0A914IE21_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9032.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9032.t1"/>
        <property type="gene ID" value="Gr19_v10_g9032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037403328" evidence="1">
        <location>
            <begin position="33"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9032.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19644" checksum="FA061B881F87A446" modified="2023-02-22" version="1">MNSFYWTKTAFVSLLMISSITFEATCTGPVSALFNSLIVGITSANEGEHSAASISNQRPLELKLADAQMLQQWIGQIARKIVVEDGIFAGNYSRGPNININDVILTDGLPEERIKKNAKKLKEVQNLEQKGQFLKLLFSFGAMLSAEIGEQSQQNGTLRALLKAYECVVEQFPEEKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE54</accession>
    <name>A0A914IE54_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE54"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9390.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9390.t1"/>
        <property type="gene ID" value="Gr19_v10_g9390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9390.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10654" checksum="5AEE9F4329645207" modified="2023-02-22" version="1">MFTLAFLMHKYLKQLSKTITSKDLTAKMVEMNKQLSRNLFIQASMPLLVYLSILMYLITFLFKLNEWNWLQYANVISTTTATIGRMRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE88</accession>
    <name>A0A914IE88_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IE88"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9090.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9090.t1"/>
        <property type="gene ID" value="Gr19_v10_g9090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000211">
        <property type="entry name" value="Polyubiquitin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="174"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="430"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="684"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9090.t1"/>
        </source>
    </evidence>
    <sequence length="759" mass="87310" checksum="599C56AC9FBAAB6D" modified="2023-02-22" version="1">MKRDDYYRYLAKVANKRSFVDACQQSYQAAFDIAKTKMEPTSQPLALNFSVFLLLRNAQLFREGLRTRRQTAAATTISRDTASPTCQNHRGCFESMGDGFNDVTSQKHHAGTPGETEQLAVRSSSRARRPIKRYVGEVNDASGRDKKVSRTSPRNIRKESTKSVIDEEEAADDQTVEKVLKKRVDGDRVEYFVKWEGLHSRWNCWRPRDVLKHLRVVKQYEKEQMHEEEEEDESDEEATRAHNDIVTTYSSASSASEQDESGNDEGEEESDKEEKKDDNLEEEEHKEDDEDEEVKRKDVNLEEDEHKEDEEDEEAKRKDVNLEEDEHKEDEEDESDEEEMKDDNLEEEQHKEKGGEDDEGNDVNLEEEQHKEKGEEDDEGKDVNLEEDEHKDEEEDESDEEEKKDDKLEEEEQHKEKGEEDDEGEDGNEHVVERILAKRINKNGEAEYLVKWQGGSDKMNSWELIDVMKQHFDVFKQFESSAAAADMEKACGHQNSSNASPPGPSKRLSCSSLPEPIWAIDLYERRRFRGGNSRALCLECGQSLETYSATLTRHIVEEEHHQYASKLLEKQLELGVANLTPTIWGIDLFERRQFRNGNTRAICLECGQSLETHIASLIRHILELGDGDDVQLQQPLQKKLKLSLTSSSFLLVVANESQESGSINANTTRRIQPRGQSATAVPTMQIFVRSLKRKIITLEAKVENTVADLKEMIETKEGIPLDDQRLIFAGKQLEGKRTLADYNIQNNSTFDLVRCFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEE9</accession>
    <name>A0A914IEE9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Odorant receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEE9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9456.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9456.t1"/>
        <property type="gene ID" value="Gr19_v10_g9456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9456.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41263" checksum="736AB7189E8BB9E2" modified="2023-02-22" version="1">MDVLFFDSKEYERLYNCSAYHIDQIPLNERQHLLIGAIFIACSIIFEVLYIPCLIAIQKHMDSTCYKFMFYIAITDMMCLPMCGIITGYLAIIGAVFCTAPTFIYIAGAYGLALWITETTAEIFLAFNRCVELSSSWLAQLLFHGKRIYLWLVFPTVYGMYVLTYTKPIIFSSLHSTWFINPHIGYINDGTIYRNDCQSVHDVIVVTVLPGIYLLLALILYFKSRVIKDETNQATSIQSQKKIFIQVLLISSVNAITSGIYVTMQFVPLSEFVLFVAQFFWILAHGIPPVIYLMLNKTVRRDVYILLVRHLAVVFPCITAPCCQSNCSTINECGCVIDDRMTSKFPVLTAQKYLSKTWHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEW9</accession>
    <name>A0A914IEW9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEW9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9974.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9974.t1"/>
        <property type="gene ID" value="Gr19_v10_g9974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="57"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9974.t1"/>
        </source>
    </evidence>
    <sequence length="355" mass="42203" checksum="52AC246E647BEBDF" modified="2023-02-22" version="1">MELILDNLYNEPSSPAAFAGVTAPWKEARKKIKDLRRKDVQNYLEGHRTYTLMRPRRVRFPRAKTVAAGFMTDVQVDLADFQTLSRHNRGHRYLLVAIDVLSKRVFVVPLRNKKADEMVEAFKQLIGQMPMVPHRIFSDKGTEFKNKLLKEFFEDQEIEKHEPVHSSVKASIAERAIRNVKQRLYRYFAQKENLNWVDVVQKIVDGINRSPSRVHGMRPIDINFQNSQQVWERMYGKQIESKRQRFHKDEFVRMSREKGQFEKGYLPNYGDEILEVDEVLKKVRPVRYKLRDDKGEKFKGSFYEQELARVRKDAETSYRIEKVYRKRRKPDGSTEMLVKFIGYPEREWINESQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFK8</accession>
    <name>A0A914IFK8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Strictosidine synthase conserved region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IFK8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9449.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9449.t1"/>
        <property type="gene ID" value="Gr19_v10_g9449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="5">
        <location>
            <begin position="164"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9449.t1"/>
        </source>
    </evidence>
    <sequence length="446" mass="49906" checksum="DC0F3793520A2FA4" modified="2023-02-22" version="1">MGILGTLSIVSSLVFFGIAVWFSANNFLPKEYHLPLPPALTGPLTVNKPNVLEKLLDGKILGPESIVVEKNVLYTCTLDGKCLKIVSGQIEKSIPMTAHTNCDGKRQTIPFCGRPLGIRRYNDQQFIVADAVLGLMLINFDEETKELLVPSMTIVEKKRLGFPDDLDIAADNDTIFFSDLSAKYGYSDVHLAFLEHVNDGRLIEYKMSTGKLRVVMDGLVVANGVQMHPDKQSVLVCETAMARIHRYYFSGLKKGRQQIFVDNLPGFPDNIRLSSNGKSFFVALAFHRSEKSPHTFDKLGPWPFARKVLGEFIKLLPDSFVNYFYAGSVHGIILELDLNGVIVRSWHDPNGSVISHISEADDDGGEFLYLSSFVNNYIGRIILVINLFSLFLCLIKQEFKAIQCSRLSQTFNNSNREVSTSSLTPMPVRRQYERHELATAIACSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IH69</accession>
    <name>A0A914IH69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g9864.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9864.t2"/>
        <property type="gene ID" value="Gr19_v10_g9864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9864.t2"/>
        </source>
    </evidence>
    <sequence length="1642" mass="184540" checksum="35F6F80B2C7D8C46" modified="2023-02-22" version="1">MDFDYFQPDSPHYVPNICDDDANFLQNEHEQQLTQPEQQSPEKTAAFTIIEESFDLAQQMDTSTHSTHTYVVVENGNPVVDEDVPVEQQPPASSESESGQNLVQIESEIILPSSSSTTSANIITPVCRRNLEQANEPMPSSSTNASSGVGKRRTKVNRSSNITYSANNSQEPTTYRDRRGGVWRLVGAFPVNEQLEAHIRSKYSVYAYVVKKPSNMRCTRYVNKRCPYKMLLQRPGDGRDNVQEQKQLNALRGAAPLLTPATPDGGGTALLWERNEHNHKHVQQPNNGTTPKRSPHHSAFNWHAEQQDWHCLGRDWSKSKIRNWIRRYGVTLNNYGRREQHKYYRCRFVTVDGHVCGYRMKSHKTNPAAGDDDDKYTVYESKARHDHGTAGAEDEPGMDGEEDLGEEAEEEDDNDGVDESMAHPDNANGPDDAVADQQDVQADPGAVVMTNMGFEQSDDEAPLEEDAAVENDESSSLLLQSIDVNVLGVTIARGFRMRNIWIRKRRIESFKARRASLMAGGGGGDDGVHKHAEFDGQNSASDGIVEPVVHVEAANGTETVDDNDEESDETAAAAAAVQAVIASIVHSVSNEMVVDGAAGCGMEVDDGDVITARAPPSSSNNNDKVQQQNALVVNNNNDAHSSVFQTTATATELGVVANADNNVNSSGAKLRWTLIGHWGRTELFKEVVKRELKLFGKNGNISYYYKCYAEQCAYKLRASRLRYVAGDAFNIHELGTHSGEHPLSPSRHGKKSGISLSTECVRKRVNKEHRKLDERTCRMARRRFEHKWLCVSNSWFKEELDQFVEHHELQLYTWLGLSKLYYRCTKRPEPNDFPCPFRLRATLNREEDEEGNEPLSTDTYTISESLEWHSHQTEMVRRKRNVLQKVRLFEWDFLREIDDPQTLDKFRRAHYVHAPVDDFDLLVQGTLACQWEQRQRKDATLKCLKCPYRMLIYKEFADGPLKVYEKGAHVHEQPPMLKPCEPIRPNRCHFTNALSRRIKMSSRIEYRRRERLQQKLRGDVKAVVQSMVTSVVHQLDGFVDVLGQVVVGKKRNDDDGTGAVAGRKRKRKQNMKIGGGRRLRRTAVQTRSAAKRSKMEAGDDGIDYVAGGSGGDFVSQRMGAYVLDSSSDDEAPAAVGPQRERRRASFLGIGTSGGTYLDNSSSDEAEVCPDEEVDNALNVSLADDFVVAFHACPCPDQLLEDDTDKENGTGRGEQRIDQHASIETVTLSEHDDNDDRPRPLLSTPNVPTIEERDRQMLFAVGMRASPVIEIANFEGIAMRHSFKVDPEDMNKGMINNNNNCELVVGEEDLPDDRTMMQMERSNTVNNRSVGRSSNKPKQKMINTRRKGRSTRVRMAVKLISEKGTGMKKTKKPVRKRLPLKRSVEQRTTAREEAVVVGVVRKKLRTITTAVQTATKPTTHTTTVVDRGQERRSLLMSTKKSHNNKNMTMKQRDSAPSTFAVAVVDHHHPIDHRGQLTHSTPAASSAYVPPYPYSPIGTQHCTPPSSSTSQHHHHHHQQQQQQHSSHFHADDLLRQHGFGTVVIQQPIFSLSDADTMAMLKQIGAEQRVSLVERSGSFLFIPPKGSVHYLGGKLLALTHGTDHIRVDEFREGNLVGTVERWPRTIDALPLFIKHLHQKLFRFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IHM3</accession>
    <name>A0A914IHM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IHM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9982.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9982.t1"/>
        <property type="gene ID" value="Gr19_v10_g9982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037656569" evidence="2">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9982.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19002" checksum="A5901B30BE774FC3" modified="2023-02-22" version="1">MEEFWILILVLFFATNSLEKAESVKVKLEELPLKTFDEIFGEGWWDNDKDEEWNKLTLEHNFHYQIDRQNTQIGQIEPNSTDQNPPLTESDHSGQIEPNSTDQNPPLTESDHFGQIEPNSPDQNPPLTELRFPHGSSAELAERPVTGLRKAGDVINWAEFPLHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPX9</accession>
    <name>A0A914GPX9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-bound transcription factor site-2 protease</fullName>
            <ecNumber evidence="3">3.4.24.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endopeptidase S2P</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.</text>
            <dbReference type="EC" id="3.4.24.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.85" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914GPX9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10258.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10258.t1"/>
        <property type="gene ID" value="Gr19_v10_g10258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="12">
        <location>
            <begin position="479"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10258.t1"/>
        </source>
    </evidence>
    <sequence length="959" mass="106334" checksum="CE82E60D13144A18" modified="2023-02-22" version="1">MPSNQQRRVHVKGSRPLSKADKLKIRQNRLIARSHPDFLEERRSKRKQFLDEGFVPRSDDDEEGAGADQLFGEIGMDRGKKKKSKRGTADEQAEQLFRDIQGDEDDDDSVGSLDEGEEGVEDDDDGMEEDMTLGEVGSEADDDDEDEDGAPPDEFSSAPPKFFGLEEEEEEEEEEDGLGAEEVLDNVELGSKRRKLSKKKRDALKKVEKIGAGTYRVQMGGAQFEVVSLELGSSTFASDQCADGFPPLPTVASAGRIPITFREQLLQISTAKKRSKRKIQWLEKTMSNIILSAASLEARVEKTTIFVVLFSWIFVLFSDFYLRYFNSQRYINFLEKHRISVTPFQVRVYLSNFESHPRLTFALLKSVDRCILGLRRRSSRFLAFWFTVGAVVSLCCFVLTPFYLFRLLLDEFGAVIHGPPPVRHLPTHFNPQSHAEPTAPIAVPSHHSLLQFPVREHFHSGIMPIFPGLNIPFSHIPIFVTVLILSSIVHEAGHAVAAANANVRVTGLGVFLFAIYPGAFTEVEPDQLERCSCAQRLRIFGAGIWHNIVLALLGVLVLLLIPVLSLPFYSNSAGIVVVDVDPKSGLYGPTGLRAGHHIQRINQCEVRNASDWAACFGQIWETSRPHPAYQKGFLAQFKAVAQMTASNGHIIQAQADGEVQCCNEFNVSNTTHICFRYLAPLSADVQPSKGPSAEQQTATPKPIFPKFPDFDAEFGVKSDGSALQRAQAVHLRRKRANLKMHFFAQTKVPNSAGHQKSGSNAIGGVNLPPADFGINARSPRKYSHACLPAMQITEHALCDSPSSSSSSFGILDASLTATLPSGYVCVVPALYNDTALLRFLVTGQARPVLFIGYLNEPLHMVEVAELTPRFGLIPWWMPRVAELFARYLITLSLAMGILNAVPCYGLDGQFIGTTVVDYFCQNWPLSVRKRMSNMLVTSGTVIFCSNILIGFARSLFNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRH1</accession>
    <name>A0A914GRH1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretory carrier-associated membrane protein</fullName>
            <shortName evidence="5">Secretory carrier membrane protein</shortName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCAMP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GRH1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10624.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10624.t1"/>
        <property type="gene ID" value="Gr19_v10_g10624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10624.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36445" checksum="BE8F112ACFFF7ECF" modified="2023-02-22" version="1">MSTLDGNPFADPFKDPAVQRVVSPTSRVGNSSTGRAPTEEYNPFTPTALSQDQPTPTAVKMNEEELFRQQEELSKREQEQNRQQRPPRQQNQAQSNGVGIGAQRQAHNWPPLPSFVPLEPCFYQDIDVEIPGQFQDTVRWVYHVYLIYVLALASNLVASLLYVLFAGGPFGLPFLAVIQLALFTPCAFLFWFRPVYKAFRDDSSFNFMVFFLVLFLHTIFCLIQALGLSEYACGWSDALSVIRTHIFVGLVMFCSALCFSLAFVGMSLSLIKVHRWYRGAGFSFDKARQEFSSGVMADRHVQQAANQAARAAAAHAVNEMSGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT25</accession>
    <name>A0A914GT25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11119.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11119.t1"/>
        <property type="gene ID" value="Gr19_v10_g11119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11119.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15256" checksum="F1D319B7D90068D6" modified="2023-02-22" version="1">MRNNKHFAQMWLFKCGHSAIFVVKRMPFRLIVAIVIAHLCLTQLPEQHQDQLGPAERTTKAKTLFVFHGYEMRKDRIIAEGRTQVWRCVRKSCTGRAHSEVGTTDLVETTKHNHLADPDSTTCVHQISCNCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTQ1</accession>
    <name>A0A914GTQ1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914GTQ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1113.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1113.t2"/>
        <property type="gene ID" value="Gr19_v10_g1113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="15">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TAZ-type" evidence="12">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1113.t2"/>
        </source>
    </evidence>
    <sequence length="497" mass="55232" checksum="AE76D6B844CFC876" modified="2023-02-22" version="1">MDSPTSEASFDFGDILTAERGGGTFKENGGTFEVEEKSGDELGAADHQGQTKSCQLLANVVVLQHQTLLKMEEYQKEQRHNQTEICAQIGELKKLVGPVPAGALTEQRRAEAVQALRANVAATEKEHQKLLMDHEVLRAEIAEMKRLQKMQEQRQAQMLQRLDEYGTEAVREGMEDGTEMVKEGTDDGTKAALNRLNARQLRGGVVQQQNQQQQQQMPGSCGGGGPLQDDEKRKLVQQQLVLLLHAHKCQQRERFELPQHRLPCTLLYCAVIKGVLEHMVGCTAGRQCQYKHCTTSRQIIAHWNNCSEDECPVCKPVKRWYTNGTAADRRQALTPHNRWDVVACCKGLTLIEPKRLIVQCDGEFNDCVCCGVFAERPIPKKNVGIFYYELKILQNKGSVGIGLASKQMPVEGYSAVCKGAYAYLAWLVVPGDVVGYGLNLGTRQVIYTRNGARLDTKDVLPSHSASDLFPYALLPSFGDKVEANFGPNFLFNIADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW09</accession>
    <name>A0A914GW09_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GW09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11290.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11290.t1"/>
        <property type="gene ID" value="Gr19_v10_g11290"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="574"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="732"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="473"/>
            <end position="554"/>
        </location>
    </feature>
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            <begin position="72"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="317"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11290.t1"/>
        </source>
    </evidence>
    <sequence length="878" mass="99231" checksum="E3A653A32F34CF8F" modified="2023-02-22" version="1">MPKRTRMLGRRFLWTEKRLRTENRLLRQRIDYLERESSALADRLVRGQVDLAQQADACLNISHELNTLRDINSEAHRRLEDAYETIRELSCKRAKDKIDQGAQIDDTSMIEHIHQLQQELIEAHTKKADLENIAREFRRRTQELESANKRLKECPPDGGIALIQEELIQVKMREAEASLSLKEMRQKLAEVEQQWTRFMNLRGITAVQLSASPSVSLDIAQSPPPSSMEEEPPQEPCQSPTPPSSNQQNTQQPQQNPSQSARARIAKLTATLMGAVGSNANINNSSAISESGGTAETLEGWSQRELEDNFIGLKIREADTVAELKEMRQKVMEMETQNHVCTNQLKRQDEEIRRLREERDTFVQMERELREELRDNERKLVVSQSEMKEKNVMQRLKYTEALQAVAELKQQIAQLESKNAEKAARAQIRGSSVYGLDNESLASSTRSVASLDGIQSLPSEEMAAFIAGIKSGKNRRKNEDEEEDEGAETETNEAEEDARADLCAEEGMTELSNGRGPVSRRAAARTPEESPDNNANNKSHRHNETSDSGLSLQGFLNTNHKHSIMGSIENKVEVSIRVASNDGNDAEVLRSLIQELANFQKMSDGPKLSANHLREHMKNGAANALIAAVTEGNETTDLYIRPMFRRRKAGSGFMSELMKISRDLSCDAMHWNVLSDNDSAICFYKSLGAQDLTFKRSDGLPELLCWRIESADYDKAIRSSKDTLPDIKMTVVMLNDVTEENAVQLIECWKSLDVFSPPFAAEKQFTKMLRDFRFGVVQAQNMTDDAVLGMALFHRCAFSTWTGPYITIDSIRVRPDHRRRGIGKKLSTEIVRIAMKHFCSRIGWTARADSEAKAFFNTMGAINLTEKEGWLLFQLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY33</accession>
    <name>A0A914GY33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11440.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11440.t1"/>
        <property type="gene ID" value="Gr19_v10_g11440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11440.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7779" checksum="F95CB8FB98E2D126" modified="2023-02-22" version="1">MLLEEKEEEGEEEEEEGGEEEKEGEKEEKEEGEEEEEGEKEEKEEGEEEKEGEKEEKGKEEKEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY75</accession>
    <name>A0A914GY75_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12242.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12242.t1"/>
        <property type="gene ID" value="Gr19_v10_g12242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12242.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="26927" checksum="A1D145F51686C3CC" modified="2023-02-22" version="1">MPNSKKEANSSPRCCCGLVQLNRVAIALAVFEFVVFSLQLIFYVMDLCNNDDEFVPESACSDAAAASAVPTILTIISLCLAMTAAVLLLLGVLFRAPYLLVPHLLMQVALMIASVVLIVHLCSWWVGGIKIDVSVTAIEHSENGYQGLLTAKNRPPITAKFTIDALSTIVLFLIILNGLFYGIQIWLFHAIITVFRGLLEQSKKDIVPPKNTLPPSTLTQFKFKMSDCPGQAIPYFVPDVNFVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY80</accession>
    <name>A0A914GY80_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GY80"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12247.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12247.t1"/>
        <property type="gene ID" value="Gr19_v10_g12247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12247.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="37014" checksum="DC5C76FC0B86E9C1" modified="2023-02-22" version="1">MALLPATTPRPIGKFPKGLIKGSLPILASSALYFGVDTLANALEDDDPPADHSVLITVLICLGGLALLILLKLLTILINYRSRPEATPPDPSLELGDLRAAVSDSILNHLKISAVPSDDPPPSPSQPLTPSLVRSTGTEMEIDNPADPPHHTEPEWAHTLESSLPPDRNPLASSPPGTQPASASIYSSFSSCSSPPTPNSASSTPSAAHPDLEPTPNFVVTLNELPGPPVSHTPPHPRVRGPSPAPTRPTTPAQPIEVIMGVTGRAAPRNSAHPPFNPRPAQRPGRLRHVRRSAPTSRGRFGASGRAPRAYVHGRWPRWRNGPAPPAPERPIPLNSIRFDTPPPNLPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYC6</accession>
    <name>A0A914GYC6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-terminal amino-acid N(alpha)-acetyltransferase NatA</fullName>
            <ecNumber evidence="4">2.3.1.255</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50500"/>
            <dbReference type="Rhea" id="RHEA-COMP:12701"/>
            <dbReference type="Rhea" id="RHEA-COMP:12702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:12708"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:133372"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12703"/>
            <dbReference type="Rhea" id="RHEA-COMP:12704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12709"/>
            <dbReference type="Rhea" id="RHEA-COMP:12710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64739"/>
            <dbReference type="ChEBI" id="CHEBI:133375"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50508"/>
            <dbReference type="Rhea" id="RHEA-COMP:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64741"/>
            <dbReference type="ChEBI" id="CHEBI:133371"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50496"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133369"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.255" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYC6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12283.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12283.t1"/>
        <property type="gene ID" value="Gr19_v10_g12283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12283.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25307" checksum="940E4D240306C941" modified="2023-02-22" version="1">MNIRQITSLDMINVQDCNLLCLPENYQLKYYMYHTLSWPHISFVAEDTKGTIIGYVLAKMEEELEEGEPHGHITSLAVKRTFRRLGIAQKLMDQTARAMVEVYNARYVSLHVRKTNRAALNLYAHALKFDICDMEPKYYADGEDAFMMKRPLVQFALDSGIEPADRSTFFRPISERKGKGKSGAAGACGASTASAAAQQTQKEAEENNKEKGGVGTADKERDGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYF0</accession>
    <name>A0A914GYF0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYF0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12301.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12301.t1"/>
        <property type="gene ID" value="Gr19_v10_g12301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12301.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23651" checksum="D7AEAAFBABFE78FB" modified="2023-02-22" version="1">MPVAIFYRRLGTHSNRPLPITVLANDNCFAWPVHCSALVFVLVLDEATASVDFATDGLLSKESLCQIAPQPLRPSAEHFPSHFRLALIQETIRREFGHYTMSTIDWRLEKGPIKILDQNLGKSRRARFSIKILIGTRPFSTTTAFGVLVMAECTNFDSPQTLCWPIKIQCSLQWPPMREFDEGGNERKKVLSITIMFVVIVVIYRVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ54</accession>
    <name>A0A914GZ54_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914GZ54"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11737.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11737.t2"/>
        <property type="gene ID" value="Gr19_v10_g11737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE RDGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="811"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="851"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11737.t2"/>
        </source>
    </evidence>
    <sequence length="944" mass="105657" checksum="BEE82FC488018CAA" modified="2023-02-22" version="1">MGCGPSTSKSHQHNHHVSGPELPDVHVKVFTYPLPPSPPLVKRNGGKCAVRSPSNSWHAQQPTSVFSSSSNSNRSVHPTSTHNELCKYASSASLGAQNDDARRLPRANTHLPLSANTTQRHSTDATAPSGAVPRAQALIRDEAKRSASEQSLLCRTDIGTPPQQLLQLPGTVLMPPDASEAAQDASGGSAVPTPRSISPLQQQNAAVSRSPSPKRPFNLSAFLSSDQLAADTVSLDSIIGGSNSKLAMTNTVPKSSVPRSNGPTPRASPLHRFRHRQQHRPRSPQICTRRDVCGTAPAFSSQASSCSNCAEHPALYLPTQSDPAILIQKWYRRCLARLEARRRATWNIFTALEYAGEQDQLKLYNFFNEIITAMAEREDLTGRNDICHAADEAEKDAKLWELANPELFRVDKSYKGPTIALPLRSNHVETMIEHFKQNKILPARHLLTILHEARKALKAMPTLTHVSTHMSGQVTVCGDLHGKFDDLCIILHKNGFPSLDNPYIFNGDFVDRGGQSIEVIAVLLTFMVLHPTAVALNRGNHEDHIMNLRYGFVKELQTKYKDSASAIIRLLEDVFSWLPLATVVDKELFVVHGGVSDKTDLDILQQIPRNRYQSILRPPISKLPINLGKKSVDVDEWRQILDILWSDPKPQNGCWPNAFRGGGSYFGPDVSKKFLEKNGFRLLIRSHECKYEGYEFAHENRTKCHILCNTWPAKCTKRSQFVKGLALWNKFGKIDSTGTGRISLPVWCQVVERVTNLGVPWRVLATRLVKLSEDGKFVLYRHHLRVHVGRNNDQHQQFGQDTNGITETLYRHKNTLETLFRFMDKDNSGLVSMKEFMEACQVLGQYANIDLNERSIQNIAESIDFNKDGFIDLNELLEAFRLILGFFSTNFKRKLIFKCLDSCVNAKKAENAVVAFFEQRKAERTTRRECTTAPIKKANVEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2L2</accession>
    <name>A0A914H2L2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2L2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13417.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13417.t2"/>
        <property type="gene ID" value="Gr19_v10_g13417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22204">
        <property type="entry name" value="H1_KCTD12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057093">
        <property type="entry name" value="H1_KCTD8_12_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23110">
        <property type="entry name" value="H1_KCTD8_12_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="237"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13417.t2"/>
        </source>
    </evidence>
    <sequence length="526" mass="58724" checksum="7AB8E2761F2F30B5" modified="2023-02-22" version="1">MSSKPLYGKDALTESPKIERELEALHQKSKQATKPIWYSKYILDDPKIGIRYFWGFTVVTTVLFCAAIRRTKTLLPYIFHKNGPPTQQQSPQRMKNGETPEGTKLTGLFSDWTKFTILRGGRKQLGRPPPLSLAEHRLKPHAAPSTAENNGKILSHIIQKSREGSAKPTNSEQFPQRESLTGKEPSRGDEAKEKEQPRRTPVDEIGPGSDYFSDELNADSGLGMNMGMAVGLEVPEGVVQLNVGGTCFLTTIDTLKRDGGALLSQLLTLEGLEMNSKVAKRMSNGTIFIDRDGELFAYILDYLRSGKLLLPENFRELARLREEVQFYQLDELMQQLIPFYNLKYPPKTPTGQNNGSVTLTAAVAAAVAKTNALYETGGFITLGYRGTFAFGRDGQADVKFRKLHRILVCGKAQLCREVFGETLNESRDPDREGTERYTARLYLKHQCLERACDNLAEKGFRLVTACSSGANGLVTAATVQPAISGANSQRESGDMEEQRWAHYTEYVFYREPQFALFNSPDQSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3Y7</accession>
    <name>A0A914H3Y7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3Y7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13425.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13425.t1"/>
        <property type="gene ID" value="Gr19_v10_g13425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13425.t1"/>
        </source>
    </evidence>
    <sequence length="974" mass="111451" checksum="3414352F02F0C916" modified="2023-02-22" version="1">MVKFDWIRSDKPVVSQINLLGTPACRIGERPDKCSSTPVNNRADSMVRQTEEKKSPRKRKRVKLEQQEEEKEKPSHRNHKSRHANDLSSTSCSSSSSSDGEENDAQANNELLALTVNALTQLLAKADKKTKKKLLKATVQSLSPSSKEKQRRHNSKSHIKSERTHRRSSPHKRREHKRRKNGEKTEEANSPGPSSSLTSTPRLSSFPSIVPSSFSPMFTHSSSSSDGREKAKVLTTKTNSGNKVTRKTIVDNSHVASTDPSLIPLPNGSFVANSLDEFLRPPPPPPLSFVQALEQGQWMLEGLDWRAVRAKWKWKDRIMNQRRRLRIPGIVPTNTAEKNDLVSVEERMSVLVGFRAEEARKKRIEEELMRLLVDKKDDLFQRKVLMKLKENTRNDSNGGVSEENVQNKVNGSKDDYAVIGVQQTNPTTDEDSRETVMGEEVVEQTQHREELAEQTQHREELAEQTQHREELAEQTQHREELAEQTQHREKLAEQTQHREELAEQTQHREELAEQTQHREEVVEQTQHREELAEQTQHRDELVKQTQHRQPEPIKWSLCAVDGIVKPISRAQELENYRNKNRRTANSKKLKSTKLNFTQCEENDASRDVIESQQMDGTDCIDLDGKCFSFEQRQQTSFEENNDNRTISDAVDCPFDAEAFGAHSVMDGDEQLVSMLGLAYQLDETIVSDVMETFDSTLKGEGGYTNDQQRCEAGHAENDSNDVVNAFCSVENQAGIEHETGCVGQQNTFDSITEEHEDYTETRGNQQNMFDSVEAEVEDDTEIRDDTEMRVDQQNAFDLINSRPDEVCDEFCGDQSLRVPYSPLNANEYDDEIEEGEVVDDAEDNRIVSDNQQNWCEHGSTTFEASLDERKQQQKWEEQQVDKRIETGTMFPEERLVSREEEVGDNDFTLRVSVPAPMTPPRLASPTDEQRIPSPKTPPLQWTSYRSCIKMLQRREKRGKTNVLDVITLDEEYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5Q0</accession>
    <name>A0A914H5Q0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914H5Q0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13456.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13456.t1"/>
        <property type="gene ID" value="Gr19_v10_g13456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="64"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13456.t1"/>
        </source>
    </evidence>
    <sequence length="569" mass="63636" checksum="80C1F89BDDC1BF4E" modified="2023-02-22" version="1">MAETELAQTDHLSSKRPGNTMDVVSLTEASSSTWNATGLSATILEALDTLNFPFPTPIQSAVIPPAVKLRKDIIGAAETGSGKTLAFAIPILEQWLESGNGIADNEHSQMEDLLFALIISPTRELAVQIKDVFKAFSAKIGPRTLKVVAIVGGMSEQKQHRLLKSRPDVIVATPGRLWALRQTGAEYLADLSALRILVVDEIDRMLEQGHFEELRHIVQDIHRAKKEQKIRKSVGSDELKSAVNVSRPPLQTLIFSATLTFTHHIPLRRGEKAPQSSMDPQQKVRRIAHSMCMRKGSAHLSVVDLTPPQKTPQTLIECRMNCGDLLQKDSNLLYVLKRYGGRTLEIGGREDVVAAWTDEGEGTAEERGQIQRVGRCRPTTEGYIHRSGRTARASNAGLSVLFVDPLDLHHYLKICRNLNKEEDLQLLAMDAPKLMESCRSLVQLATEAESLEHTLKKRKSRDQWFERIAREADLVWDEGETAMKRKMGRNDADEGPSNEELMQRRKRAIEKTLKGIVTSRGQQQQHVREGTGDGAEGGEKMGRETESVKRVKLEKGLKKWVKRARMDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6J8</accession>
    <name>A0A914H6J8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6J8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14477.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14477.t1"/>
        <property type="gene ID" value="Gr19_v10_g14477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037915932" evidence="2">
        <location>
            <begin position="25"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14477.t1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45360" checksum="18A97F7740679BF6" modified="2023-02-22" version="1">MPPFLFLAAICLLVAASILLETDAVGPSSSGNAEPNAGFHGMPPTPQSSNFTSGNTGSSSHYGGVMPYQQVPPMHDTFMPSQAGTHSWDWSGDNLQNNEGSLQSMVNPKNPRSSHYGSTMPFQQTRKYRQNFFENALGLGKRWLPIPQEPLPDNVIGFESIWISYIDRSVIEFLQRIHRLFDSNGSNLFIDTDNDQSGSWESIWQMIWPLFNDNIFGFLLSPSNLFRLRRFSPTVLGYCAKLRMIKSSALFPEFPADDSAGASAEQALAKWLHTPRGDGLPKVLKCEFCSAKMEGLKRKFVNSTDPAHFIISLWNWSSAVSIAPFELKNILTGQRLGFRRFDRSNWLLVRCPIERDEEKWANWEKEAVEWNWSQWNFISIYFEERRVFCTLLEWFGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6Z7</accession>
    <name>A0A914H6Z7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6Z7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14583.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14583.t1"/>
        <property type="gene ID" value="Gr19_v10_g14583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14583.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38778" checksum="273B7AC2BB575C3F" modified="2023-02-22" version="1">MTLRQNGPKSALCVLDGQKVPDFVEHIFEGVARPRQRRRRRPRRRRLNGTEWDGRSKDARAKLLRKLVRGGGGGGKDNTKMFVVGVQCVCLCGKCGFIRRHAAAAHVQTDRTEQASRTDGQDEIVHVYCLRPMADRRTEEDEIVHRLHVGCTKTKKQTDRLLLDLDGPLQILCGQGASNEFDMYNSLTQCAAAAILLCLFLLVSGSDNDAKLDPSMTPKQFNPSAFPAMPPELEKVLPADVVQKLKAVHGDKSLSIMQKQDKIDRIMSALPGEILDQIPAPPGFERLPDEVKARLKKINRQTDKPWADKQKELQAYVKTLPQEQRAILMMGPMGGPPPPPPSFGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H776</accession>
    <name>A0A914H776_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H776"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13851.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13851.t1"/>
        <property type="gene ID" value="Gr19_v10_g13851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13851.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="16456" checksum="3441B536292C77ED" modified="2023-02-22" version="1">MSAGAVVQQQQQQQQGSRGVSSGGVVRRRSWRVHYTRPKKNKSFEYETSTGSAYEEVAPSSHSTPLCQSQPGSLIFARRRRSSNGGGGGGTGGDLDMAAVAVPSSASSIVVTSAAVAATTSTRTAAGTVLVRRRSSNNGGGGTNAKAKMPVQSRRSTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H786</accession>
    <name>A0A914H786_GLORO</name>
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        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchoidea</taxon>
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            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H786"/>
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        <property type="gene ID" value="Gr19_v10_g1386"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="65"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1386.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31040" checksum="24E4EE7CE67AC464" modified="2023-02-22" version="1">MTEQADQQAKIDELENALQTKNFEMEHRKLLIDHKSLQEKVVKLEELQKMQQKSQEEMLLKMDELQKAFAELSDGRKANGLTPQNRWDSAACHDQLALSEPDRLIVHYNGKALARRSVFAELPIPKKSFGIFYYEVKMLGKKGSVSIGLATKQMPLFKCIGFYKGSYAYGSDGNFIGHEVVEGCHQIINGPHIEGKRRFGVDDVVGCGVNLATGQIIYTKNRRHLKTTGLFVDSAAELFPSVTLCDPGTKIEANFGPNFKYNIDHTIKKLEKDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7Z0</accession>
    <name>A0A914H7Z0_GLORO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7Z0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14650.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14650.t1"/>
        <property type="gene ID" value="Gr19_v10_g14650"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14650.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14398" checksum="81985AD90B4A91D4" modified="2023-02-22" version="1">MGITRRHNAILDRFAKETIRGRPAHRVSRPSWRPSPTIAADVVSNAIRWSRDIYIEHITGVPQFNDDGNANCNQHLPETTDTGARTMPNQDSPARLISWIPRSNLALKLAAGPPEHLKMLFQNHSCPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H812</accession>
    <name>A0A914H812_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H812"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15068.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15068.t1"/>
        <property type="gene ID" value="Gr19_v10_g15068"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15068.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18239" checksum="D34963E3FA90C7FB" modified="2023-02-22" version="1">MPAPTNFGQNVHHQIDRQNTQFGQIEPNSTDQNPPLTESDHSDNDNSSENIAEDERKYKIVAKKLGLSERTLYKWKSELVESKPKHMYSDSEQMELMKRYYEIKDKNPISDENIAKMLKIGTRTLVYWKKQFKQKQLHQNSVAAANVQEIGISNSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H885</accession>
    <name>A0A914H885_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H885"/>
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        <property type="protein sequence ID" value="Gr19_v10_g14636.t2"/>
        <property type="gene ID" value="Gr19_v10_g14636"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14636.t2"/>
        </source>
    </evidence>
    <sequence length="106" mass="11825" checksum="ED4F69E4C58AAEE1" modified="2023-02-22" version="1">MQDPDPRAQYYGEISIGSPPQNFTVVFDTGSSNFWVPSIKCPIKDKSCSLRHKYDSSKSSSYQPDGRRMILMYGTGAMKGFVSKDSVCVSSICVQQQEFAEATWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8Q3</accession>
    <name>A0A914H8Q3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Minor ampullate spidroin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H8Q3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14787.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14787.t1"/>
        <property type="gene ID" value="Gr19_v10_g14787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14787.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="10076" checksum="3203286B01505869" modified="2023-02-22" version="1">MAGQSVSGAAHAIPGAGQAITGAGQAIPGAGQASTGAGQASTGAGQAITEAGQFMAGQSVSGAAQAIPGAGQAITGAGQAIPGAGQASTGAGQASTGAGQAITEAGQVLSRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9A1</accession>
    <name>A0A914H9A1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9A1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14964.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14964.t1"/>
        <property type="gene ID" value="Gr19_v10_g14964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14964.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14740" checksum="89BDDE73CDF18720" modified="2023-02-22" version="1">MHFPKSLFGIALPKWIVSEQYGGWVLGFYALIFMIILPVAVVLEGDDEVEVEQQDEDRLLDGQQFTFGRNGLAVGKALGGRGRMESEQNRGEESRTPKQQRRLWGRVWKNGLDPGAIGVNWALTTGRRVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA93</accession>
    <name>A0A914HA93_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HA93"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15223.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15223.t1"/>
        <property type="gene ID" value="Gr19_v10_g15223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15223.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37349" checksum="FBE3A62F2B59B584" modified="2023-02-22" version="1">MSSPSAVADPTPTDVPSTSLFAVGTLSAKMKMLTTTAKSRCEQAFGQLRVPAFGEERLAEWRAGYERVKDLYRLQNTMEWRVIKLSFWTAFGATTYGESVRRFAVYTAGKLYTDKPHNHLRGRRLDYALTRFNVQGCKVGLKLGIGVTTIVSLILVPTTFRAHFSLINIPLATIPVMVFGANTTFRGWGMAGWRACVPATIYAVSCPVLAILCSCAYHRCLPDTFYWQYKMELVAYTSDRGKFKMFRYMPWTRREMEHERELGTWRWTSGVEDGLVHLEEEEEQKKEPDQKAAAAEDGDELDVEEEQAAKLTASLDQRRRAWWRLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAX9</accession>
    <name>A0A914HAX9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HAX9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15684.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15684.t1"/>
        <property type="gene ID" value="Gr19_v10_g15684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="73"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="270"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15684.t1"/>
        </source>
    </evidence>
    <sequence length="514" mass="57577" checksum="FA26CA4E20B4F8B2" modified="2023-02-22" version="1">MDKEANIESTSSPCNLSAGQSPLSNGETTPLKFHPFEPFSICSWREIGVSPWLIKQLEEFNLRKPTPVQTNCIPKILEGSDVLGCAKTGTGKTLAFALPILQQLAIDPFGIFALILTPTRELALQIGDQFAAFGRQLKLQCCVVIGGRHQMAQAQELSRRPHVLIATPGRLADHIESDPSGIARLLKTIRFLVLDEADRMLDGQYATQLKVIFDALPTKRQTLLFSATLTSALNRLHEVSVRKPYFFEEKDTIKTVDKLEQRFVLCPRNVKDAYLVFVVKEFYLRRDDTSILVFAKTCRECQALALMFKQLGFEVGSLHSEILQSVRAASLAKFRAGRIQVLICTDVASRGLDIPHVDLVVNHNVPRCPKAYVHRVGRSARAGRFGAAVSFVTQYDVVLLKAIEGAIGKKMEELKVNHNEVALYAGKVLATKREAEIRLERRGFGERREIWKRKELAMEGLEEDEIERRIEAWKTGGARRKREEDAGETNGTAGSWNKRIRTARNSRNSDPAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBB1</accession>
    <name>A0A914HBB1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBB1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15495.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15495.t1"/>
        <property type="gene ID" value="Gr19_v10_g15495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15495.t1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43862" checksum="7113F4684A27D04B" modified="2023-02-22" version="1">MSDNPNNPKKVEKQLNEIFVCNDVLFDVFEFCGPFVLGLKVALLSDRFDFLVDAHFNSNGLALGNLQIRRLKKGKGAKIVKFVDNKVARRLPIPQEPFPDKVIGFERLLISYIDRSVIEFLQIIRRLFNSKETTLYIETDTIQKRSWKIIWHRIWPLIKDNIRCFCFFYSELVPLRQFSPTVLCDCPKLRVIESFDFFPEFPPDDSAGASSGQALAKWLHTPRGDGHPKVLKFCRFHSEKMEGLKLAFVNSTVAVNFIMCVWDWFSAVAIVPFELKNNLTGERLELRSFNRRGNCMLVRCPTERDEDKWAEWEQEAIEWNWSQQSTRISINLEDKDIGDGLLDANEGPSEPKKKELRTNGIWRVIQNGQNIVIVTTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBZ4</accession>
    <name>A0A914HBZ4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBZ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15947.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15947.t1"/>
        <property type="gene ID" value="Gr19_v10_g15947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15947.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36038" checksum="517CE6F5430084D1" modified="2023-02-22" version="1">MSIPWVEKYRPKTLRDVIGNPEIIDRLIEISKTGNMPNLVISGPPGCGKTTSVWALARDMLGEKVKDACLELNASDERGIDVVRDRIKRFASTKVTLPENAHKIVILDEADSMTEGAQQALRRIMEVFSSTTRFAFACNQSDKIIEPLQSRCAIIKFGKLTDEQIMERLVFVCNKEEVQYNPGGITAILYTAQGDMRQALNNIQCTAAGYGTITKDYVYRVCDEPHPEKMYQIFDCCINGRTQEAFDLIDGLYCLGYSVDDLVGVMFKTSKIADIPEVLRLEFIVEIGKCHALIVQGVATRIQLAGLVSRLSQVKNKLEMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCE2</accession>
    <name>A0A914HCE2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCE2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1576.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1576.t2"/>
        <property type="gene ID" value="Gr19_v10_g1576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000019">
        <property type="entry name" value="Ligand-dependent corepressor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545:SF13">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 93F, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545">
        <property type="entry name" value="TRANSCRIPTION FACTOR MLR1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH psq-type" evidence="8">
        <location>
            <begin position="756"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="723"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1576.t2"/>
        </source>
    </evidence>
    <sequence length="874" mass="94370" checksum="0F5B8AEFC5D22838" modified="2023-02-22" version="1">MLLAQRPNYATDAANPPKRHYLHSFQYHRKNGSNTLPPPHPPISSRQNAASYPPRPSIFLRRFILFQRSVQNCHLTSADPPIFPATTFHNARSHPFNFSKKSSDVCNDRCSAERRVHCRELSKGSRQLLMLVGLENVFQRALGPRQWRKFGQAVKIASSRSYSADFELDLSKNCNWCLGSRQRVSSFGSQSLLTMNDALLDDSSSLGRQLSSTHLLPPLMTIPGHSSPPSASSSAASFSSSSIHSSSNASSSAHLPPDSPKRAPPPSETPLPSCSSSATNSVPDAMRLLAALHQQQQMLMGSAGAMNGAERMAMAAAIHLLGATMSSPASLNGGLSAGGSAMLSPPPAPAFLPAALLSSGFYPWPALLTPHPSFPFMALPNNSSSATSPSTPPNSVPNMFDIHQQLTMAWQSQLFALRLMSSFNEFCPPPTTADVQRDTMPSEDEALAFLAAFGKYSRTKSPTENGDQQPLDLTKSVGSLNQSSSLNAEKEKKASEKSRGGDQMLREFCQQVNKEVESGGNASAPPLLLIGIDGVGGGEDSSEAESPKLGTKRTYSQADLDAAVTDIRMGRLGTRRASVVYGIPRSTLRNKIYKLEAAEDNGDGSCKRRRLTAFALHKREQRLSVHRSLTESASGDSSFAEGEDRGGEGPGKRTADTPENAGEQSSEPVPLIAQMPSALLRQQSMPTFPLLGAGSAAGQFLKEFSSLIKQKVVSQSTKGAAEGEITETKGAKQQQQQLQQNFKTERREKNSTISSRPKRGQYRKYDKDALVRAVASVRSGEMSVHRAGSFYGVPHSTLEYKVKERNKLRMAKNKKSSGTNASPKNAGGEAQQSIANQKLSLLESEVQKTLEFVLNTVVHGAKTTEGETNTDRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCQ5</accession>
    <name>A0A914HCQ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCQ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16148.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16148.t1"/>
        <property type="gene ID" value="Gr19_v10_g16148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967">
        <property type="entry name" value="GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967:SF10">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16148.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="26327" checksum="A72D7DDF6419CAC4" modified="2023-02-22" version="1">MQQDTFWRRNLFELNLEDNMDNINDNDDIGQQQQHYDLLFDQVGHGKHSQRAGWVNGANFFIRANNQTHAFFEAVADKLAHWYAPDMGIMIHQCNTWETPKCAFIPHKIANSWEWMYTDQRNAPHVIQLDCETDGKTKLQQLARFGFYFTKRDGRTCDPEAVQRTQQIMDKGQVDVGGPVRLSWGRFQFKVYWWLVDYILCTPLIGPYLKTYLPLAGYILTVTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD34</accession>
    <name>A0A914HD34_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD34"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16395.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16395.t1"/>
        <property type="gene ID" value="Gr19_v10_g16395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000203">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0736">Signalosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="15">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="728"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16395.t1"/>
        </source>
    </evidence>
    <sequence length="806" mass="91618" checksum="328CD287A278F1B4" modified="2023-02-22" version="1">MERLLRLGGLGGLGAGALNATPHDSNQVDTSETVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVNVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSDRAVAVVVDPIQSVKGKALIHGLNRHYYSIPIAYRTSENEQQMLLNLNKQSWMDSMNLMNYSEHCSQTEKSVEHMLKLAKLYKKSLEEEEKMTDEQLAIKNVGKQDPKRHLGDTVNQLLADNLVQSLAAMLDVSAFHACIPFQQCVSTVKKSVSPQLSPFSPPKNAEQLGRSLLDVETAIKLLTSPLPLSLLRSLMVGCYMRYHAIREILKDSDSNFYIDKIIHVNRDGIRFKHCRDNSYRSIHKIKAPENEIDQRVFNLWTSDMKKWNEPLPFMDAQASKLDSIKKALASLPAEETKPQPDSDCKPLEVKHKPCDISRIDLTKLVITVEEMVKLIDYGRELFDHTVTGFYTQIRAPPNPSVSKDKKSNESGIFMDQIIGVSWATRPYIMFQRPLTIVLKFRHFRDERMSQLPYWNKPDGISQEVYNQWLDDMRQWDEEYPSREFIAHKAKELATVLSEPPRGPPVDVIKLATIEAERENSTKLLKKLKEWQEEQNAEHAMFQPSPPPWQSFYPPPLRPARFPHWPVRYEALRPRPPQTYGRAACYQPYPRFHRPMASAARHPQMQLPMPYATSSPYGFYAYPQHLPSNHQSRFSPKAPKYHPPAKAGASNPIHNPSSSKALPSAKKLQPSRGQPNNRLPKVYHPQNDYATFEAAVQMGYSGNVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDW4</accession>
    <name>A0A914HDW4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDW4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16234.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16234.t1"/>
        <property type="gene ID" value="Gr19_v10_g16234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037823688" evidence="2">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16234.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="25724" checksum="3BA1E12CFE4A4ABE" modified="2023-02-22" version="1">MIILLLCTLFFTASANPISQFPSGGDKTSSEKEQNANGGIATPISSWEFPAAKELSNKSLNSAEIKKRLFQGLLPFVPQVNPYGNPMMTNPALMNPMLNLGMNPMMTNPALMDPMLNPGMNPMLNPDMNPMLNPGMNPMLNPGMNPILNPGMNPMMTNPALMNPMLNSGMNPMMTNPALMNPMLNLGINPMLNRGMNPMLNPGMNPMMTNPALMNPMLNPGMNPMLNPGMIPMANPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG13</accession>
    <name>A0A914HG13_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17032.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17032.t2"/>
        <property type="gene ID" value="Gr19_v10_g17032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17032.t2"/>
        </source>
    </evidence>
    <sequence length="70" mass="7933" checksum="651FA9F44B1A56FC" modified="2023-02-22" version="1">MHFANFVIVSNAPFPYLLATTSQPHAVLTPPKDELPPSSLFDQIVLKPLIDKWKGRFCVVREWLVASKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGA2</accession>
    <name>A0A914HGA2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HGA2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17231.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17231.t1"/>
        <property type="gene ID" value="Gr19_v10_g17231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="82"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17231.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28163" checksum="5B842819AB576185" modified="2023-02-22" version="1">MPFQSTANGPLANFRVEVAKSENAREVLEFLFADFLHNEPLNSAVGLTRTECANFFAELVQISLTDGLSYLVRDPTEDGRLVAIRLANIMDRKELTNGTPNGPGPEKDGQRPKRKQSNGQPFQGHRFENDKIRNICGILHSVETKIWSLLPSHIDRLLCWLVISVDANYRRQGIAQALLLHRLDEAVGLGCQGAFTEASAINSQKLFSKLGYTRLFELLLADFRDGLGKQVFRCKDGTDRVTLEFRLFDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGJ8</accession>
    <name>A0A914HGJ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGJ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16975.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16975.t1"/>
        <property type="gene ID" value="Gr19_v10_g16975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16975.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40204" checksum="F2DD5E19AA56916B" modified="2023-02-22" version="1">MSDNPKKVEKRLKEIFVCDDVLFDVFKFCGPFELGLNVALISDRFDRLVDAHFKTREWSLGELEIRRAAGGIGAEIVKRFGKRRLAIPQIPIPDKVIGFQSLRISYIDRSVIEFLQCFRRLFDSKGSNLSIKTSVDQNRSWQIILDEIWPLINNNICILFFDPSSLDRLHQFSPTVFRDCAKLRVLEVFGPFPAFPADDSAGASFGQAVAKWLHTPRGDGLPKLLRCISNKDGIEEGLKMEFVHSTDPVNFIISLWASSNVHIVPFELQDNLTGERFVCRRCNNYWLLVRCPIERDEDKWDEWEQEAADWNCYGRWNCVRIDFNDSAIDDGLLEVEAKKGPSEPKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGJ9</accession>
    <name>A0A914HGJ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGJ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17300.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17300.t1"/>
        <property type="gene ID" value="Gr19_v10_g17300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17300.t1"/>
        </source>
    </evidence>
    <sequence length="468" mass="50476" checksum="C588A65FE3A2C54B" modified="2023-02-22" version="1">MDIVTVPPTRCAAVCSKSRKMAANSPECSLGRRNFVRRVVVFAVLSICLLPIVPSAGDDTTGTAFTTAMPTSTPLYNQTVISQQNGSDNDPSRTARAADNATAVDAGSGGANGTAEDAMSTTIDWWSSMGTQSPLAQRDSPSANSSVSNSSAAMTAVSSSSSPNSTSLSSDNSTTTKNDAVPCFLHLFTLLIALFVNPVKIASFSKKSFLEMVTNESKQRTPPTEFLLNDATPLFVDANHRLSYALVGQLPTECEKMAKSNKMEKHRFVHAVMALANAGGVPGERMKTSHKAPLDPSEWERSRSLELDGFGLISRPAVVDGKGWDSFGSSQVDEDARRRRRRVDPIEEAVKVLRDTTAMLGQMLNDWRAGEGPPGNGEEDDDAIWPSRHRKGSATASPTTALDTEAPALFARLSPMPTAQTEKDFEVETRPCRTHGTPLSAIISFPSELRRYRMMEGPWEEIPEGATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH62</accession>
    <name>A0A914HH62_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH62"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1732.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1732.t1"/>
        <property type="gene ID" value="Gr19_v10_g1732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1732.t1"/>
        </source>
    </evidence>
    <sequence length="1154" mass="134510" checksum="5DB3FD663255B82F" modified="2023-02-22" version="1">MPKVDEAVSAGEFVLVEVVSSDQFALEDLCLLKLFQSDQFALEDLCLLKLFQSDQFALEDLCLLKLFQSDQLEQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFALEDLCLLKLFQSDQFALEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFAQEDLCLLKLFQSDQFALEDLCLLKLFHAGGFVLVEVVSYDQFAQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLAQEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFALENLCLLKLFQSDQFALEYLCLLKLFQSDQFAQEDLCLLKLFQSDQLELEDLCLLKLFQSDQFAQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFAQEDLCLLKLFQSDQLEQEDLCLLKLFQSDQFALEDLCLLKLFQSDQFAQEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFAQEDLCLLKLFQSDQLELEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFAQEDLCLLKLFQSDQLEQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLEQEDLCLLKLFQSDQFALEDLCLLKLFQSDQFAQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLELEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLELEDLCLLKLFQSDQFAQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLAQEDLCLLKLFQSDQLEQEDLCLLKLFQSDQFALEDLCLLKLFQSDQFALEDLCLLKLFQSDQFAQEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLEQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFALEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFAQEDLCLLKLFQSDQLELEDLCLLKLFQSDQFAQEDLCLLKLFQSDQLEQEDLCLLKLFQSDQFALEDLCLLKLFQSDQFALEDLCLLKLFQSDQLEQEDLCLLKLFQSDQFALEDLCLLKLFQSDQFALEDLCLLKLFQSDQLAQEDLCLLKLFQSDQLAQEDLCLLKLFQSDQLAQEDLCLLKLFQSDQFALEDLCLLKLFQSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHD0</accession>
    <name>A0A914HHD0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16631.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16631.t1"/>
        <property type="gene ID" value="Gr19_v10_g16631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF69">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="297"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="659"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
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        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16631.t1"/>
        </source>
    </evidence>
    <sequence length="691" mass="77428" checksum="8B518F645D0ADAA1" modified="2023-02-22" version="1">MSFAVRSGGSVKKKKSDEVSLVQKKSSQDQLVDQQGPFRSCLHLYRKPLAVNALCLCFLLFYSLFGGFIFLHFEEPNWKMSREREMAERLQCVEGAISAGRANANGRAEEMLAERIVVRCVLSQGRDERMEWNLKNAVLFGFGILTTLGYGKIEPQTTEGRLFTVFYGFLGVPFTVIIFTNFGRYLQRLERCVRKRLWRQWRRFAHWRHNASNSKLFRPGGQRKGSWMLPPITVLDEEGHGDVVVVRHQNGDEVGSGTERAQTVEEAQMFVEDADDDEAEEDEEEDQISPLTLVFIVFLYLLLGAMLIDWLDDSVDFANGIYFAFLCLTAIEYGKLIPTDPFYLPLVIAYICFGLAISTIALDIGSTYVKRLYYLGRKIRNIASIKIWFGAKHLRVRELLAALGHNIGLEPTVLCDLDLEQLISSAIQVKEGRLHRVPQTHMIMDGIWPPELVPLFLKDGTFPEWVDADERRKWSVASVMVRRRSIRGGSAATATLSQPLHKQSSMSGSARSAAAASLLLSQPPERTPPLPPVQPDRLSVVRFEEFVRTQEDDRRLLLSSSSADAQRRKCCYYPPMLLTEEAEPDSTTSGINSDPDLSFVDTTALPTSSWSLSVPSSSGGCGGAIFPPTQMRRSETVPPVGHPDSSLFYMCTFPSMEMSGKKAPPLPPLAPLPPFTEAEEEEEDEVGYGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHD8</accession>
    <name>A0A914HHD8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHD8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1664.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1664.t1"/>
        <property type="gene ID" value="Gr19_v10_g1664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="239"/>
            <end position="261"/>
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    </feature>
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            <begin position="273"/>
            <end position="297"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="468"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1664.t1"/>
        </source>
    </evidence>
    <sequence length="565" mass="60955" checksum="58F09EE50E7426BC" modified="2023-02-22" version="1">MLRPSFSKRSSTEDIASFNCQSEQRPTVTYPSSVGFALSESPTCHSSFPIPCPTPMVVADLAVFQLDIFWAIIVGFLIAFVLAFAIGANDTANSFGTSVGSRVLTLQQAYLLASIFETLGAALLGYQVTDTMRKGVMDLSIYEGREKELMLGQIAVLTGCGAWLLIATFFKMPVSTTHSIVGATIGYSMLLHGTDGIRWAKVTKIFASWFVSPILSGCVSILIFLFLDHAVLRRSRPLHCGLLLLPFLYFVCVSVNVFAITYEGSHYLGFDKWPLWSVVTLSVGSGLVVMLVTRLFVVSRLKRYILEHTIGSELSAEQHIGLDKNLDGVMTAQPPKNLSEGKTALLGKGKAEGNGNEPSVKGKTPNGEMAQSAFGSASIRPASSVLSFFRSSKPEDPYASKLFIFLQVLTACFSGFAHGGNDVSNAIAPLVSLYTIYDEGSVLQKGDTSVYLLLYGAAGMCVGLWLLGHRVIYTVGENLTRITPPSGFSIEFGTALTVLFASKFGLPISSTQCKVGSVVAVGLVQAHPVVHWTVFRNISLSWLVTLPIAGVMSAVVMLLLKMFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHE9</accession>
    <name>A0A914HHE9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reelin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHE9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17530.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17530.t1"/>
        <property type="gene ID" value="Gr19_v10_g17530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF42">
        <property type="entry name" value="DEFENSE PROTEIN L(2)34FC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037034246" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="3">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
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        <location>
            <begin position="554"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="762"/>
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        </location>
    </feature>
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        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
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        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
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        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
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        <location>
            <begin position="899"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17530.t1"/>
        </source>
    </evidence>
    <sequence length="1210" mass="132257" checksum="39E3AA413EF7DFD2" modified="2023-02-22" version="1">MALLFLLFALSFDFSSGWPDGAPCLRTVYESMNPLEAVEHQGGLQLSDPPFTIELDAQCYYPGQPISVCLHGNGSTEFKGFAMQSLVFDAFRVGTRRTGQFLRMDDNGSWQFQCFRIRDSVTHSHDDKKGRMTMWWRGDFNGETVQFVATVVQNLKRFWVKSVVSMPIPPCSTRASFGPWNKGTPTVPPPTDNFKKETFELFNPGSAAQLISEISAVPAEGRSRLLPRPSSPPSQPDPVFFRTPEPATTIATTPSFFRPNQQFQRFGQNSACRDKTSSRHCLQWIQFCPTNPWMGQFCKATCRIISSFLLDDQMHPSQHQQLQTFGNSASANSAHSSPMKRVPPPALSPLASPMESRRLFVPPASAHPPASSSADHSMLNALQLGYTLAGPAQPARLLVDPHTGQQYFVPTAPQPMPYFAAPTPLYYPNQFYPTPASTATAQSQSGFMFANQPPTTLWSPQPLSSATPPSLLRQRAQSPSAVSSALGGRHHHQTQHSSSAYHVEVPLSSVGSMCEEAEFEQYQHQQEAFQRQQQIRLSSESRGSLRSAVGNNRLEMNSNRMDLNGNDRSSPPQTASGHTQSVPPRQLLQLQPDHHSTGGSSSESTSGFASGRDRLRTGDISDGRSPPQSPFMRKERTHFLSGQDEDGNHRRSDSPKSPSLPKPPAPRMKAIRMDIDLNRPVSPPEQRQVSVRTTVVRTAPPTAFTISFNDVSSKAMDIPNSTDRPVETGHDVREPSLQEAARQAPTGRRLMATRRNVPPRPVPERGERIGTDSGDLRGKDSEDGDGHGDELGDDAEDMASETGTYVVESKKMSQSQPPVTSTVSPRGEQSGNSVHPSTCSPSSSASSSSRTPSPSLMEGKGAKRSLMSDLRRLREQKSAATPPKPRAFPPAVPAPQRTLMGQNRPCRQQMPSSNSTKKTGNSPFRPNSVGGGGSRCRSEPRSDGGRFSMRGTQPMKGQPNAMPAKDAAVHQQSPEMVAWLRRKEYDPRKAAAAASTDQSQKETHQRQQPKSIAPLALPEENSSGAGSEEAFMASRSFSTSATTKSPFARWRQNRKTLATGDQRSNRSHDDLSRLGESLDEESLPGVAVDSCSSSLQRTVDELTQKCHKSIALLKLCNQSGLSSSVEQLLERVVEGESPEEVEDQFGAVGSDGKSNSENISDRLERLSSAFDAIQKYLEEQTSVSSSRASLAALGKMATTTESVQKTNAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHV0</accession>
    <name>A0A914HHV0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17508.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17508.t1"/>
        <property type="gene ID" value="Gr19_v10_g17508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="531"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17508.t1"/>
        </source>
    </evidence>
    <sequence length="865" mass="98453" checksum="9293FEAF493AEAF4" modified="2023-02-22" version="1">MGSIAEEIRKIKQAANIPPPATLNRYVDGFASIYVFEIRPPSYGGAFVFRYDVELTQLNRNKSLTSGAGDDGKNGLLRSVCFDLIKHIHTSTKGFGAGAEFVYDNRKNLFTNKLISPMVLEVNPEQVSEICRDFLRGSPVKVEIKACQTEKHELDLNDILPSLSKRPDEQSDRSLRTFLEMLTSQPFLNLGTHDIIGAGRLFKREVCKELEDGIVTREGVAKGVRIIDNNGEPKAALVADVKTCAFFASKNLEEIVKDMLRKRRIDINNRSQMERFWPDFNQLFRGVSGQRTMSEISFEVDGRPMNMVDFFRTKKNIPVNGKLPAVRQQQDRETLFPMSCVFILPNQRVTIDKMSDFISRELLNANTTHPSRRYADIEAEVKRIGTGASSQFMSQFGVKLVGGKNDVKIGLHELPKVKFGGNVTTSFQDKINPGVRFLETSNLMKSWVVGFPRQVGEDSVRSFVEQVVRMGRSKGMQLSDPQFECIELENISDRMQQLSERRVQFLFYIDKRFVKSHSILKLNEKKFGLLTQHVTFEVASKARAMTLSNVLNKMNMKLFGFNYMPIFPQITKNKFNMDGGDVLVIGIDTSRPAKASPFEKFQLRKKGTPELTSEDPLIVGICANYLKNPYKFCGDYYFQPCKQDVLEPTALTYKIRWILEKIKKHRGKAPSVIFIIRDGVSEGMVPNNVRDEFPSYMEACKTIDPNWKPKFVYCIVDKKHNKRFFVKGQQQVENTAPGSVIDSKFVRVDIHEFWMQSHVPLKGTSKIPQYVFPVNQVAANNNELQSFLLSLCCNWQIVTLAPALPTPVRQAGELAKRGRANYMELKRGSPQYIPRVAGTEQIEYQLLNKRLCYNGHAFAETRFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJN9</accession>
    <name>A0A914HJN9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJN9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1933.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1933.t1"/>
        <property type="gene ID" value="Gr19_v10_g1933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052949">
        <property type="entry name" value="PA_immunity-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42999:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42999">
        <property type="entry name" value="ANTIBIOTIC RESISTANCE PROTEIN MCBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1933.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33887" checksum="3370766AE7165DE6" modified="2023-02-22" version="1">MEHFVYGINIFVEALKVKNLLPHNTDAESVWALKEKEEEEELETRTLEEEEEQLALKEEQEEEEEQLALKEEQEEEEEQLKQKKEAEKMTLKWEVELEACTLKEEELESCTLKEEEEEEELKACTLKEEEELEVCTLKKEEQELKACTLKEEELEVCTLEGEDLDACTLKEEELEACTLKEVDLDACTLKEVELEEEQELKTCTLKEEELEACTLKEEELEECTLKVVDLDACTLKEVELEGEDEKEQEFELNMFDLDIWTLKKEEEEKFESCKLNKEEAEEEKECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK83</accession>
    <name>A0A914HK83_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914HK83"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2092.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2092.t1"/>
        <property type="gene ID" value="Gr19_v10_g2092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2092.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27517" checksum="DF0FB433C45CD9AE" modified="2023-02-22" version="1">MDLYFTNIQPFLDFPIVEQEIEQKRKNTQQNRVNFIGGITMSKGKVPSLNPDTKQIFESAKDGVVLLSFGSAVEMDDSDERAVSVKNIVVDVFKQYPQMNLIIKWGKRTSSGTVEQYNKLSENVYAKSWLEQTAILGGGLKLFITHGGQNSINEAVKFSVPIILFPFFGDQYNNAEALAARGVSKVLEIRSKTLNNELTEALHEIFNKYSEYKAGMDELSKKMNSVEPAKEFVEKFRQLRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKB5</accession>
    <name>A0A914HKB5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxy-3-methylglutaryl-coenzyme A reductase</fullName>
            <ecNumber evidence="3">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HKB5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2267.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2267.t1"/>
        <property type="gene ID" value="Gr19_v10_g2267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="608"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2267.t1"/>
        </source>
    </evidence>
    <sequence length="755" mass="80379" checksum="86B53087DB8A430E" modified="2023-02-22" version="1">MAAALATNCIDLNQFSTDICSTVEKIVLERLGKEFGEKIPNETATKYSCIAQTQFEIIGEKIRNAVHELCRHLAERCNNGGGIVVDGARSRGPSFIIGDDSSSTTSATPSIASSGVHSAACCSDEGVQVDLPPPLHAVPVGVATSAPMQRHNKAVVVAEPSSRTVASAAAVAAAAAAPPATVAQPTTPEDAQVLAELRQGRLKHRMLEQRCSPTKAVELRRRHLEEQHQMCLQALPYEHYDYGEVKDACCENVVGFVPLPTGVAGPLYFDGTLVHLPLSTTEGALVASVSRGCLSINEAISVLGDNAFSVEVFRDGMSRAPVLEFPRVRDAIECLRWIQQNQTFVQLKHIFEETSNYACLQRIEAHLEGTYLYLRFVASTGDAMGMNMVTKGTGRALVLIKRQFPQGELLSISGNMCVDKKPSALNWIEGRGKSVVAEALIPAPIVERILRTSVDKMVKLGHAKLLVGSSAAVTVGGWNAHAANVVAAMFLATGQDAAQVVSSSMCLTQLQQRTEDGALHITCTMNCLEVGTVGGGTMLTPQGTCLEVLGCRRGGLRPGQNAERFARLVCAAVLAGELSLLASQCTEGDLEKSHLRLNRSSRSLALSLVSGGTNSRSNGSSPQHFAPSSSTSSPFRPFSCGGGGGGGSAMHNIPEHSPLLSRLTQNNGILGPERGTGAGAAAERREQQQLQHHRQRQQQQRRSGTLTSMDGSSGGSNSRSGGAGGGGGKLRKIGQILHYKNFRRLWVVFRARRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKD3</accession>
    <name>A0A914HKD3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:42713"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HKD3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17671.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17671.t1"/>
        <property type="gene ID" value="Gr19_v10_g17671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17671.t1"/>
        </source>
    </evidence>
    <sequence length="687" mass="77652" checksum="A3BBFFBD81EC3DF1" modified="2023-02-22" version="1">MCLYSVGPPRINIKEEIWDQYRRFRAGDIVRIVDEDDGKGYFAQVSAFITDNYAQRFALIIWLLPKLVGSSFSSTSEFNPDKFQHGLAEERPVPIEACEFISECPSFSPYKRGWTPSNQILVLKRKEIARRVEGAEILSANGCCLIKITNFSPHVGTVQLKKFINSRLGEVPFRKLKFAGRTVFITLNSEACAESAIQLLDNVFFKKSCLRATKANDLRISQKRDLTERTTTGEAVKSCRELVTPLADVPYEEQLRTKYKQSRTVLELLGKQMGQANASKSFDTKQMLLQNVLPSPVTEGYRNKCEFSVGYSSDDDHSLPVVGFVSGKMANKQCKVMSPGECSNLTLNTRSIVRHFEEFVREFGEKPFDEFERTGFWKMLTIKDFLGDTMIIVTVYPHPNKEVTDKSIRMLKERFLPSNSFSGAETAFNVTSFYWQEQVNAGDKRIYEHMAGTPFVYESLLGLNFRISPSTFFQVNTRAAAILYEKIGDLLNLPTERNTPEQDESIQKQPIVVLDVCCGAGTISLCLMQRIRNAIRAKKFDAQIPFGCVGVELNTEAVRDARQNASENGFDAKSCVYIDGDAEKIFKELEYHMPSGCQLNSSQIFGVIDPPRAGVSDKVIIGCRKLQSLDTLCYVSCDPKAATKNLVDLCRPLSRKFDGNPFRIVTIQPIDLFPQTEHVEWVIKLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKU7</accession>
    <name>A0A914HKU7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Galectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2251.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2251.t2"/>
        <property type="gene ID" value="Gr19_v10_g2251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037823798" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="588"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2251.t2"/>
        </source>
    </evidence>
    <sequence length="1153" mass="130421" checksum="FF2308C63B84EDD7" modified="2023-02-22" version="1">MNAKCNFIKSILCFLALLHAAQPQKKTNPTRLTGLGKNLSTIPVALLDQCFPYEESKTFGIEFRLPRTGGRCDDGLIICYTGSLATRTLDNVHSMNGLSVNSKLFNVDNAVNNSLAKYCTEAMNVSWHGIKVHTEKSSGKSIIKLSTSLLEDKEQSFEIPDAQRQFIIHFGNKNEFSAYLTVEGKRIDLDVEKAKQYMKLAPKGAHLKDFVGFWTLGLDMLPWMDHEVELYVNRTCSCTMEAWFILPTDLEEFNDPDMPTSGLAGDNCPKNTDITVPLNKTLQANHMILIRMLTDEQIQNVSFEILAASESGIEAPLMAFTISKSGADICYRVNKAAHFDKPFDWVFENVHLPEENGSRQIDFIIALTEYSYGIVMNKRLLGGQEFYPANWAKGLPFNDMTSLRVRGQFLLLKNPLPVMSFNYVQQNYEPQIFHDIFIQSVPDLHIGDTLTFRIKTHNLRGDRHFTISLLHNRPLEEHKTIGATALRMRVWHNQIEFKSFIEHHGTQTRNTTETTINTGAMEFRIELLRSNGYEIFKDNKPVFIFAEHLPVWAIDYIRVSGSEKGVVELLGEPFIGKEISHDKDRANFTQKLNTLLNYGDKILIDAQINKTTQSFAILLLHEALKETTKIGDVVLKLEFNFNHSQATDDCNGTVQCKSLLHTKTEDGKWTNMSNATAHRLNKYGQKFTISIKCMADNFTIQIDDVAFQLNCPYPKERINTKEVDFPPWAVDHIRIGGQVAVHSLSVKHEQNSIVDPFKKQINESNGFLQNGDLISVKIPIKIKNWNDSFSVTINLYNEGLGWNPIIGKAILNVTFNETKAFYLSSYDDGDDEKRMHREAQQKCPITKLNTTELKELDFQIRVIDNRFHTDVTGFNVKFNNMDSCSYNYSVASWAVQYITIVYEKVELGTPGITCVPEERCMGQINQTEDYCAQQNCGVRKSNKTSVTEESCMGGIHPNAFLGTGKFGHQEVWAPEVWAPGSLGTRSLGTGKFGHQEVWAPEVWAPGSLGTRKFGHREVWAPGSLGTRSLGTGKFGHQEVWAPEVWAPGSLGTRKFGHRERRKSGKNHGETRPILALNPISLEKKSGEEASSTATTYHQAAWPNNGEEPIYGANPLMDPAWNYEEPRDIGIPPHYDPEAENQEFFDNIYNKYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL25</accession>
    <name>A0A914HL25_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL25"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17611.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17611.t2"/>
        <property type="gene ID" value="Gr19_v10_g17611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14692">
        <property type="entry name" value="bZIP_ATF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17611.t2"/>
        </source>
    </evidence>
    <sequence length="488" mass="51451" checksum="5D31E12DA2D6A24E" modified="2023-02-22" version="1">MSRTEMICEDVNRNGVAMLNALDNDDHLLLLNCSDMCLDYGGGTALMSRAQMVCEDVNYDRMANAGGGGEAAAVHNPPPGEAYALMEFGGSLFCVPASAFAAAVRVPPQSQVWPSPPADFAVGVPLSQLQQDEVSVGPRLPSVRHGVGGLRHSVPQSPARPFVAECAASRGALCGQQQLSAAVIVSDAVSSITALPLIRPPPESIVLASSCAFSELTTTQRASGKNAAEFVCCAAQGVPRLYCSSSSSSSSLSTDGPPSSSSSPPSASSHPPSPSPPPPTSYSSSRSFCSSSSPSSSASSFLSSSAPSPLRSTCVKPSSPPLPWQLWIDEMIREVQAEMFRAGCLSNDCSNFSSSRKRSFCSASPCSTTSSSTSGLISLDDSSSCSTSNSSGSPRPFPSSCSSQTSQPHAKRAKKNSLLTLSHEALAERKKEQNRAAAQRYRSRKLHLLEHEREEVWQLETGNAQMRAEMAQVAEQIAKLRAQLLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMB6</accession>
    <name>A0A914HMB6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HMB6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2807.t3">
        <property type="protein sequence ID" value="Gr19_v10_g2807.t3"/>
        <property type="gene ID" value="Gr19_v10_g2807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2807.t3"/>
        </source>
    </evidence>
    <sequence length="494" mass="56366" checksum="B6C92DFEF40320E6" modified="2023-02-22" version="1">MLRRFRLLWDRFCVFTDLPGFRLMHSAVPRAIRMATIFLFFSSLAAMNAQLGYLLVQYLRSQVQTSTRKYRLERMALPFVYLCHQLNGTNPLPLLDLCYDSVFKRGADDLSGDRRMQNVVPICSYQIKAFEYRCELRCKWTSQGFCMEARPNRNSKKMVTAANKSASGDENENEAAERALWREEANAAAEADDNFDEVSTYDIHIHFNASALVQQDVPSSGPGVPALALVFLRFGIDAQKSANKVPLVGAAHMIMELDSRNSIQITEMLKIVHNDLADSQLEPGTSSYEFCHWKKYSELGRRNKNNKCSSEYMTDFFAADWWEFSNVTYSSSDVQCALARSLRAQQSCREERVHNRFTVETAIYTRSDADGDADDGRPPSTPNLHIYPGDVVMQETLHQLRSNVWKMTSEFGGTLALYLGFSLMSFLEALIFFTVPKVRLNEEILDEVEKSERRHPPTKDVPEAMCRKWRKMAAMCRQSMARRTAQVNGGSNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMH5</accession>
    <name>A0A914HMH5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Plastocyanin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HMH5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2154.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2154.t1"/>
        <property type="gene ID" value="Gr19_v10_g2154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="190"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2154.t1"/>
        </source>
    </evidence>
    <sequence length="639" mass="72646" checksum="1DE408CFA9170651" modified="2023-02-22" version="1">MKQGENVLLRLANGAFEESFYVWIEEHEFWIVAVDGSYVRPIQFDSLLIHPGERYDLLIVAQKNPKLAKIELITPNTDDVDWNHKKCTKESNCAILNCPHIEFISRPLNYTCIAIDQLENAELPLSDDANIFESKNYSENQFSELMLNSMPTFNRWFYKMPKELPFFNQGPLERIATKCDAKKCDRSKEDCHCFHHYEFRLGTIVQITAVTSMNMLHPFHLHGTKFYVMKIGKMEPKYLLNRDVECADKHCIEMKWSNISYYKGNVPLLKKNPILRDTVMIPHMGYVVIRFRATNPGWFFAHCHLLFHHMNGMAFAYKVDVASGVSKIPKPPPNLPKNCGFYDGGERWEHDEDQQQNAMNYFLICLTGLSVLSNLDAFRQQSVGIRGRLMCGNQPLKDTQVKLWNKNTLGSDDQLSSFTTDNQGNFELQGGVGQMTKMNVHFKIYHDCDDGIKPCQRKVNFGVPDHYVERSAQTKKWFEAGTMNMEFKFPDEERTISDFDRFLAIRYFIARAAGQRAKAVGLSAEAERGCVVEDAGVPSGRTKPTKQTKPHKHKQTNTNSNSSHRGPEEEDLKHGQRRDVPGRLSALGDGSALFAGRPGPASSVFGPRLVSICAPPLIVTSSAPFGCRIPTDERLSADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMP6</accession>
    <name>A0A914HMP6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMP6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2720.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2720.t1"/>
        <property type="gene ID" value="Gr19_v10_g2720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2720.t1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43912" checksum="D74CF91B884E381F" modified="2023-02-22" version="1">MFKHPFTMCIAGCTGSGKSQWVQRFLHHLDPLVAGGPIAGVLYCYGEVNDHVLRLQRMASVFNNHNNNGPGSPRRVRVCHGAPEEGEVEREARATGGRLLLVLDDLLLSLRGTFLDTVFTRGSHNWGVSVVLITQHLFTPELRIARNNSHYLVLMRNPAGALQIRNLGTQLFPGAALRFFLEAYEDATAEPFGYLLIDMHPTTEVQLRLRTHIYPDDELCVVKTSRQRVGAKKVKKFASQPAKPLGSSRSAPPTAPVFSEHVKRNVRFFQQLKAAGRSQHRYRALVAGATSEQLLCLVECALNILRSRVPIQRRHLQHLRRQATNVRQLSKVRSRRAARQLLLRDPSSSSVTAATAAEADGVQSGRGLPPLVGLLASVLLPVLIQRAVGNSVDQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMU7</accession>
    <name>A0A914HMU7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2953.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2953.t1"/>
        <property type="gene ID" value="Gr19_v10_g2953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2953.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14080" checksum="D681FCC4A2B4FBD1" modified="2023-02-22" version="1">MQPSNSKEELGFKCQAIFTEICEGIVRRIAEKSFFIRNGLPTTMRLFVARQMLAGLLHTVSFISAMPKEFPETPETIDLHEVLNLAREIVTQCVNSEAVELHDLELLATFLRTKCYEINNTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HND1</accession>
    <name>A0A914HND1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HND1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2897.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2897.t1"/>
        <property type="gene ID" value="Gr19_v10_g2897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2897.t1"/>
        </source>
    </evidence>
    <sequence length="424" mass="46721" checksum="5A7C9484FE0B95D3" modified="2023-02-22" version="1">MFQIFWFGSFIAWLLFGVSRSSWLLLRLAIVDVHSNSVAYYKPKPDWGKLDSKVENSSKSTAQSTTAASRRGETPGSGRSPRVTRLGGVSRAPAPRILARSPPSGAPFLSSVAKVVFFHRAGHRFTVRVMHCNEIILCAATVTVSQSMVAQIEQKLGFAVEDQRLLKSGQRLSSMFKFCQDTVVELFLFQTGGMEEWTVNVGLAPLTMPLDCCVGFYQGSYSYENSGRYRGHYKPKPDWGKLDSKVENSSKSTAQSTTAASRRGETPGSGRSPRVTRLGGVSRAPAPRILARSPPSGAPFLSSVAKVVFFHRAGHRFTVRVMHCNEIILCAATVTVSQSMVAQIEQKLGFAVEDQRLLKSGQRLSSMFKFCQDTVVELFLFQTGGMEEWTVNVGLAPLTMPLDCCVGFYQGSYSYENSGRYRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNV6</accession>
    <name>A0A914HNV6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPPDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNV6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g253.t1">
        <property type="protein sequence ID" value="Gr19_v10_g253.t1"/>
        <property type="gene ID" value="Gr19_v10_g253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g253.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22235" checksum="C0ED492B0EDF328C" modified="2023-02-22" version="1">MEELFEFNPRSHGEFVEEQRCPCPDSELHATKFYEVECDFMDRKAKQFLNVARITLCVASVGLTLCSPVLGLLLAASTILAHAPNWGQDLTHSCLEVLYKCRLCEHEVHVTYEFMNPGETSNDCGRYSKTYKPTKLHGITTTAFEDIERVFHGMWTQYNLLYKNCKHWTNDLIGRLRSDALPPPLTAEDDDVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPE0</accession>
    <name>A0A914HPE0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPE0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2999.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2999.t1"/>
        <property type="gene ID" value="Gr19_v10_g2999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF248">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2999.t1"/>
        </source>
    </evidence>
    <sequence length="474" mass="54236" checksum="922754A6C7F5D162" modified="2023-02-22" version="1">MESDHLNKSIAEMESDNLNKSIAEMESDHLNKSIAEMESDHLNKSIAEMESDNLNKSIAEMESDYLNKSIAEMESDHLNKSIAEMESDHLNKSIVELESDHLNKSIAEMESDHLNKSIAEMESDHLNKSIVELESQIFPKKILLQNCVTDLLLLTMTLLFQPYYFTTSKGEQEAILDGLATVSGRVWPLLASVSWIFLVYVSMLGYVSQFIYRYMTLNWNHKISARKYFLLLGTMLLLPLAYCVNLFVCYCPPVDHPFMDDQSVAEQLGLNLSDNISLAGYTVNDRRVSFGFYYIIIICTSGYITMFTLALLMHKYLKQRSKMGASSELTKKMIAMNKQIARNLIVQASMPFLIYLSIIFLLIIIMFQINVSGWSWLQYYNLTLTIPMYLPSALNPIVSICVIKFYRHGFVAGIQRAVKWLKQLCCGAFQQQQQNQFMTANAQQSQEKWAISVVKVLPKIRNESRPETKSISLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPJ6</accession>
    <name>A0A914HPJ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPJ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2700.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2700.t1"/>
        <property type="gene ID" value="Gr19_v10_g2700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036996303" evidence="2">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2700.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24980" checksum="8CFB330093FBB44A" modified="2023-02-22" version="1">MEEFWILILVTFFDEIFGEGWWDKDEAAEDLKMPAPTNFGQNVYHQIDRQNTQIGQIEPNSIDQLGQLEPNSTDQNAPLTESDHSGQIEPKSTDQNPPLTDTDHSGQIKPKSTDQNPPLTETISNWKRELGQTKPNHQNSHSEQNELMKRYYEIKDQNPKIRDTEIAKNLKIGRTTLVKWKKQFKRQQFHPNSVDGPSVEGNTAANVQKIENSNSESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQA8</accession>
    <name>A0A914HQA8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQA8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2902.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2902.t1"/>
        <property type="gene ID" value="Gr19_v10_g2902"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038032797" evidence="2">
        <location>
            <begin position="28"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2902.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17922" checksum="8E55F451D553C298" modified="2023-02-22" version="1">MAYFFGVFCVVLLPLLLTLLQLGVSSSTEGFSSSSTTSSSSKAPTHPPLKKALRMFRVKPEDLLALPKEMPFLTPKMLQHRVSRPKQQLVATKQSQFAPMSSTEQFYIKHMFIIVGVLMCICVLLLLANLFWLLKRFNSRANDKKRVRLESIESEETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQD9</accession>
    <name>A0A914HQD9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQD9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3687.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3687.t1"/>
        <property type="gene ID" value="Gr19_v10_g3687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037804375" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3687.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8277" checksum="CF280D18001F6458" modified="2023-02-22" version="1">MDTGTVVLSSWLLLWASSTFRQQLSKDSLIIRIRNIRVGAMEEPQNNDHRAIGGAVGHQLHNRIGSSVQQLPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQJ0</accession>
    <name>A0A914HQJ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQJ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3325.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3325.t1"/>
        <property type="gene ID" value="Gr19_v10_g3325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038116119" evidence="2">
        <location>
            <begin position="24"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3325.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28493" checksum="B35F2C32AD7AF062" modified="2023-02-22" version="1">MNEFWILILVAFFATNSLDKAEAVKLELKTFDEIFGEGWWDKGEAEDLKTPAPTFGQNVHHQIDRQNTQIGQIEPNSTDQLGQIEPNSTDQNPTLTESDHSGQIEENIVEDERKQKFDQMKAELKRAGFKNSYNHEIDETVAKELGLCFRTIYKWKSDIGQTTPQHKHSDSEQMELMKRYYEIKDQNLKISDGNIAKSLNISRVTLYNWKKKFELQQMHQNSVDGHSLEENAAANVQEIENSNSESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR36</accession>
    <name>A0A914HR36_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3136.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3136.t1"/>
        <property type="gene ID" value="Gr19_v10_g3136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3136.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22108" checksum="83BF38BA246367EE" modified="2023-02-22" version="1">MPKEIDAVFPTRAPGPSSGPARGNGSESMEWFSPVLDNHMNRAHRRLVFEEVVQRTAAQQQQRNDRPQVPLKQPEQQMVPILQQELHAPQQQHQHQPLEEEKVDQQQQEEEERERQLERFARNVRLQLRESRRFSAGAPSSVLVPPAQIYRADESLSAFQRRRIFMSRGADICTFVWTVPCTRYSTKAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT13</accession>
    <name>A0A914HT13_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4381.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4381.t1"/>
        <property type="gene ID" value="Gr19_v10_g4381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4381.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26687" checksum="845CFD009D811FF4" modified="2023-02-22" version="1">MVILREFQLNLRKWLPHDLTDLQRQRRVEIAAPLLQQQQQRPFLDRILTLEENVFPSIIYDRKSSGFPQENRPFRCRKWTSARRRSSSAPNATIVTAALYCDQLDRVQEQLRRGTAGWRRRTTPAFLHDNARPHTARITQQKLEELGWEVLPHPAYSPDAAPSDYHLFRSLEHSLRGHSFADQDEVEQHIDDFFQGKTRDLYARGIDQLLEKWQQMVNSDGAYYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTC9</accession>
    <name>A0A914HTC9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3578.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3578.t1"/>
        <property type="gene ID" value="Gr19_v10_g3578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3578.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8727" checksum="4B6DAEF39DDDE19E" modified="2023-02-22" version="1">MNVIIFTTIWSKKESVNGKAISANCHANHNSSNKNKLDETTFSSFAHRKNSHFETMMKAILLVFAIARAVPIGVHISAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU05</accession>
    <name>A0A914HU05_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HU05"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3753.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3753.t2"/>
        <property type="gene ID" value="Gr19_v10_g3753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="259"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3753.t2"/>
        </source>
    </evidence>
    <sequence length="464" mass="52167" checksum="8A33604846B8CE06" modified="2023-02-22" version="1">MKHLLDTGNGADVHFLVGGGDEKELLPAHKLILMAASDVFKAMFPFDARNRDSSEEIKAVEVPDVEVGAFKAMLSFIYADDLSGLNGDNAIAVLYAAKKYNLPELVNSCLNFPISELNNIFFAFDEIRFLGEEHIDENADALIFSEEFLQIDQKLLCEILDRDELMISEEIAIWNAALRWADKKCRQNGKKRSAANRRKMLGPALFKIRFPLIPKEDFSEKIVPSRVLIMAIPSGVLTRDEIISIYVHHSHPYAGLSKLYPLQFPTNGRAFTAGLTLQNRWDSAACHDQLALIEPDRLIVQFIGENCGTRFVRAERPIPKKDFGIFYYEVTILEQHYAIFIGLGPEEMPLNGWVGRHKGTYAYDSWGTFWGHAVAGCFHFKDRRPYIGGKPEFEEGDVIGCGVDLATRQIIYTKNGRRLETAGLFVDFAAVLFPCVTLFNPGTKVEANFGPNFKFNIAADGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUP4</accession>
    <name>A0A914HUP4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914HUP4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4163.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4163.t1"/>
        <property type="gene ID" value="Gr19_v10_g4163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000024">
        <property type="entry name" value="Histone deacetylase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4163.t1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46585" checksum="E41566CC897A6A7D" modified="2023-02-22" version="1">MTNKRRIFYYHHPDLGNFHYGPQHPMKPARLAATHSLVLNYELHKHLTCVHPPRATQHDLARFHAPEYVHFLKRISPLNADQYEGQFHRFNIGEDCPVFDGIFDFCSLYTGGTLEGAIRLNHGQAEIAINWSGGLHHAKKSEASGFCYVNDIVIGIIELLKYHPRVLYIDIDIHHGDGVQEAFNLTDRVMTVSFHRYGGYFFPGTGDMFDVGMGHGRYFSVNVPLREGMDDESYHSVFKPVIQSVVDNYSPSVIVLQCGADSLGSDRLGCFNLSFDGHGECVRFVKSLGLPLLILGGGGYTLRNVARCWANETAILVDRDAEISNEIPDNSEYLEYFAPEFTLRPELPKRIENANSKEYLAAIKTEVLENIKLVRNSPSVQLQPVPGDALDLQDTDSMRRERREDGLDFRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWA7</accession>
    <name>A0A914HWA7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWA7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4359.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4359.t1"/>
        <property type="gene ID" value="Gr19_v10_g4359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4359.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14416" checksum="201D03264636E0B7" modified="2023-02-22" version="1">MARNAGGDGDDDDTSRRERRYNLYFGVLLWRLLPSSSSPCQADQTKLGLNMCAFCCWHSSMAARAIRHGLLDGQDTRDCSGLPPSPSPPALNPFKTTGRQIGCAVVRERIRHDSVRRTLSKQQQQQQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWN6</accession>
    <name>A0A914HWN6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWN6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5350.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5350.t1"/>
        <property type="gene ID" value="Gr19_v10_g5350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5350.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15756" checksum="BEDA29A625CC7128" modified="2023-02-22" version="1">MMFTYWPRPSAFPVPPFSQLSLPDLVELDMANHQCQCQLAPFAPHSFPKGIDDGFIYCLRQNIDNTRSTGTQTDEEIPAAGVAQYSEEVGLDDPELANLCSQLAQRLLDIADGWASKLEPMKREPEGIFGRICSSFFRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWR5</accession>
    <name>A0A914HWR5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GP-PDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWR5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5188.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5188.t1"/>
        <property type="gene ID" value="Gr19_v10_g5188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5188.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12358" checksum="E045A2E412AE5F56" modified="2023-02-22" version="1">MTIPRFPANLVHQGAVALDSLLKWSIKIFLPQFVGADMVLIERGEIYENFVEDMHNRGLRVCAWTVNDSNEMIWMAQKLKIPFLTDRPLNAHHLLDATDGVNNAEVALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWS0</accession>
    <name>A0A914HWS0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4864.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4864.t1"/>
        <property type="gene ID" value="Gr19_v10_g4864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000033">
        <property type="entry name" value="Glutamate carboxypeptidase 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="181"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="368"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="636"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4864.t1"/>
        </source>
    </evidence>
    <sequence length="765" mass="85161" checksum="3F58410BADC81764" modified="2023-02-22" version="1">MVVYKLNNFDSDSVSFRLSRNQALFFALVVLSLIVAIAILSAILLIQILAAQYGAKKVAFETEEIRSAIFANIDSGRIAANLEAFTEKPHPAGTEANKKVADRIMETWKANGLEDVHQIPYEVLLSYPKWDTPNHVYVLASNDHVLFKTDGLSPDLTGQDNSPEASIQWLAYSPEGTVQGQPVYCHHGTVEDFDRLEKQFGIANLNGKIAIMRYGGAFRGDMVHNAFQRGAVGCILYSDPEEVAPEGQEHTFPSSIWMPPSGVQRGSTLKTNGDPLTPLLPSKKDFHKERLIERAQLDPETMPQIPAIPLSYGDAYHILSRMDGPEVPSEWRGGLNITYRVGPGFKSGKGQTVRVEVHSRLEVRTIQNVVGYIWGSERPDEWVMLGNHYDAWVFGAIDPNSGSAILAEVGTGLAQTVRTTGWRPKRTVVFCAWDAEEYGLIGSTEFVEEFADVLKEKVVVYLNVDLVPSNITLSVSTVPTLYRAAVDASKVVKNPLDNKLTVFDSWLEHYPPKTDWLQGVPEMRIPGGGSDHFTFLTFLGIPVMDFSYKNPKSSGYSNPLYHSRYELPFANEQIFDNNHLAVHKAVGEYWAELARLFADSPLLPISATTFAHRFLADYLEGIKKPILSLNSQFPNDTEPAKSQLDNLIKNAHQFMAQAEAFEREQSANANLEWANVRLRKLDQCFVNPSMGIAREEPLKRHVLFAASKDNFYASNTMAMVYKKIGQLRKANNGTERAIRANELALELAVVQQAVRCAVNTLGKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXW2</accession>
    <name>A0A914HXW2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5043.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5043.t1"/>
        <property type="gene ID" value="Gr19_v10_g5043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF15">
        <property type="entry name" value="AT02057P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="720"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5043.t1"/>
        </source>
    </evidence>
    <sequence length="866" mass="94612" checksum="252130B0E531F989" modified="2023-02-22" version="1">MTLVDYASNFWGDKHIGYNVLYENMKKGEESVHELLTFLKERINVEDDLLKSLGKSLHRVNGYVSNNSGFVDAWKLARETLELWTEIQSTLLKNLNELLKEVTRYQEELGRMRKRAKDADTLETINLMQTTTTCLQKARDTYNQRCGEVGSLKQNNKEWTAASTREYLKARNKLNKAHEEYRLYMEKYSQIRDTFEERISNAARSFQEHDRLHLLQMKKFFAQMAKCFETGHGSHAQVGANLRQNVEQNINVEDLMLRFIDEKGTGTEPPQKLQWTDADELPPDLDVVSCVQSQSSSSNSSAIIPNPVSHQFLPSVNHLLGLDDSWMTVGGESGVGVGAADVQANASGSIGGGFGESIGSFGVKRGSANGFSEHNKSGGDSDSERHSEMLFSVPSSTISSTAPTTTSASSSSYVPLQISSWLGRQKLSGPWRLKKHFSASQSNLAGSITIETPTVCGNDQTKGVGMTPTSSFSKSCNDTSSKMVASGLLKRYQKGKAMKSSMGDLTLIGKAQPELTLFSLDIQNNVASEHEVVRDPLEVFGPPPPLPVTDPPSLDGELADTFSHYTVDLTRNYPFSTKSHQQQIRQHSVSFVSTCSEGTAADEQQHQRCASSSSTSSDEEEACMAAQRSKIRQLQIRPLNASQQSKLNASVDELRMAIGQISLSKCKGCENDPWGGDPTAARDGPIRAALTGDEQHLRQKCNEFPFSDFSQSVAALSAGSTISRARPRSHTPLPSKTFGVPGSSTAFFGTEPNRSETPSTPTPDRPFPASQTTPSSIVPLSADNELSTPSASVTPNSFETPATLCGGPFAQNFFISPSPMAIHPSASFSASNFKVPGTVPIAMAINEYLHVWIKPNCPLRFASLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYY3</accession>
    <name>A0A914HYY3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYY3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5767.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5767.t1"/>
        <property type="gene ID" value="Gr19_v10_g5767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037332836" evidence="2">
        <location>
            <begin position="25"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5767.t1"/>
        </source>
    </evidence>
    <sequence length="409" mass="40748" checksum="017E3FCCB1294EB3" modified="2023-02-22" version="1">MSQLAICKIICLILALQFCCFVGADNDDHRSFAEELVRRLRRSYGYSVGYGGNCACSSSHYPPSSSGSGTSQQTRYSSTSSCSGAGCSSSCSGASCGGQTYQPQKTSYHWCTGTACNKQVTQETKIVPASGNSYTSSCTTCAGGQQQSTVTETKKVYVQPVQTYTWCSGTACKNQAQPASSSSSCSGNACGQETQPAQPAQPAQPAQPAQPAQPAQPAQPASSSSTSCSGNACGGQQETQPAESGSSSGSAYGQETQPASSASCSGNACGQTQPAQPAQPAQPAQPAQPAQPAQPAQPAQPAQPASSSSTSCSGSSCSQQTTSTSTCSTCGLTGYNSGWSSKSSSYTTSSSGSGSGSGGSGGSSSCYVCGRHGLSSPITHTTTTTTSGGGSGCGSGGCRSLGCPVCGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ93</accession>
    <name>A0A914HZ93_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ93"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g516.t2">
        <property type="protein sequence ID" value="Gr19_v10_g516.t2"/>
        <property type="gene ID" value="Gr19_v10_g516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000010">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF6">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="43"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g516.t2"/>
        </source>
    </evidence>
    <sequence length="501" mass="54364" checksum="F1C1FD6AFFF695E3" modified="2023-02-22" version="1">MNNSSSPEAADLELLRQLQFRVAQVRLDLDAFRSHNDDNQNAFFLTFMALMIFLMQCGFAFLEAGAVQAKNVTNILTKNVLDSLITIVSYWTLGWALAYGPNPDISNFGRFFFQYVFAARASTIISGAVAERAEFITFFVYSLLVPGFTYPVLSHWGWSSVGWLRQGPNIGDGTFHTTYLDLAGAGVVHLCGGTISLIAAWMMGPRIGRFLDNGQLSKMEGHSVPLASLGGFILMLGFLAFNGGSVADISLPGNGQVVAKAMINTLLCGAFGAICTLILHKIRNGKWTVLLTMNACFSRNGRISACAGCNQMDGWGTFVTGIGAGLIYMALSGLMLRLRIDDPLDAFAVHFGGGLWGLISVCLVSTSAGRGVIPSLITGDGTAIVRSLAQLGWNILSSLAIILWSSFVVLPVFGLLKLIGKFRVPAEIERKGIDIWKHGEEAYPLVAYGHGWNEAEAEEVKDEEGVWGAPVATIFHDPSKYQQQQQEDGGSRKRTFVRNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZB9</accession>
    <name>A0A914HZB9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HZB9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6065.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6065.t1"/>
        <property type="gene ID" value="Gr19_v10_g6065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000040">
        <property type="entry name" value="Phosphoglucomutase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
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    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
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    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
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    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
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        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
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    </dbReference>
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        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="24"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="227"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="325"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6065.t1"/>
        </source>
    </evidence>
    <sequence length="581" mass="62856" checksum="1504C37B435AD7E2" modified="2023-02-22" version="1">MSTSTTLAAPFKTATVQTKPFAGQKPGTSGLRKRVPEFQQANYTENFIQCVLDGGLGNAKRGAVLVVGGDGRFLCPQAVNVIIKIAAANGVSKLIIGRDGLLSTPAVSHLIRKGDNGRQINGGIILTASHNPGGPKNDFGIKFNCENGGPAPDNVTDRIYQLSTSIAEYHICPNLDLDFGQIGTTTATIEGVGQFVVQVIDSVKDYADYMEQLFDFSKIRALLNGQLTTADGRPFRLLVDSMHGVTGPYVSTIFVDRLGASAESCLRTVPKPDFGGAHPDPNLTYAKGLVDQMARGEHDIGAAFDGDGDRNMIIGRHAFFVTPSDSLAVIAANLDCIPYFKNKTSIGYARSMPTACAVDRVAKARGRQCYEVPTGWKYFGNLMDAGKLSLCGEESFGTGSDHIREKDGLWALLAWLQILAHTNGKQSVEQLVTGLWREHGRNVFTRYDYENVESSGASLMMNYLQPLLSGFVGMKFDSNGRVFEVVNADNYAYTDPVDGSVTKNQGLRLLFKDGSRVIYRLSGTGSSGATIRLYVESFVDASDQEHLLLPAHELLKPLVLVALDICKMEQFTGRNAPSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZH5</accession>
    <name>A0A914HZH5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZH5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6102.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6102.t1"/>
        <property type="gene ID" value="Gr19_v10_g6102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6102.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22425" checksum="BCEDF109313108BD" modified="2023-02-22" version="1">MGAYATIAGRLLLFCFWPNLDDKFCGAIRRGLCDPVPAGHDQCFPVPTILNLFLFLFCSKILEQPVCSVPVLFRPREQNRNRTGTEQEQNRNRNRNRTGTEQEQEQNRNRTGTGTEQEQNRTEQNRTGTGTEQEQNRNRNRTGTEQEQEQEQNRNRTGTEQEQNRNRTGTEQEQEQEQNRNRTGQAGTGKHWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I035</accession>
    <name>A0A914I035_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914I035"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6080.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6080.t1"/>
        <property type="gene ID" value="Gr19_v10_g6080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037621330" description="Glutathione synthetase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="16">
        <location>
            <begin position="227"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6080.t1"/>
        </source>
    </evidence>
    <sequence length="510" mass="58731" checksum="B9C9130CC5BF2D6D" modified="2023-02-22" version="1">MIYLFQIYLATLFLFNYFDAESVNESGSKEVLISSDELNSSTNYTDNLLTILQRNRTKTELLIKKATEWAQNIGLFVRKRRFDAYLQEFYETDVAPFTLFPSPFPRKFFEQAVNVQTALNLLYFRIMRDYKFLKEVYQKLINYDKSLSTALQIIEEIHSEGIKQPLTVLFQRADYMLCEINYEGNEKPNYELKQIEVNGASIGGLGFSTRTSKLHRQILSKMDLDLSNSVENNTSTMTVEAIYQACLKLDPHDFTLRYDDKIVAVVFNQEGMLSDDPEEMEARRTIEHSTAIKAPSLAAALAHSKKVQQVLAKPGMVERFFPNPEEAPLIDAIRNTYANFWTIDEDDDNNDYTQIIQAVKKSPHKFVLKKTEYALYRNKNRIYFEQEILKRMTDFTPRERSAYILMEKLQPTAVKNHIVKTMFDKKQDVPTIFEIVMETMFGKRKNVPPSIFEDVTPELGIFGTLLGNIVDGQVLDNAQLGYQIKTKLANENEGGLASGHSAYDSAYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0P7</accession>
    <name>A0A914I0P7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0P7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g579.t1">
        <property type="protein sequence ID" value="Gr19_v10_g579.t1"/>
        <property type="gene ID" value="Gr19_v10_g579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="293"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="426"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g579.t1"/>
        </source>
    </evidence>
    <sequence length="611" mass="65714" checksum="44EBD464AFB7CC0F" modified="2023-02-22" version="1">MKRPKRDNSRTKSSSGTDGPSCNRHFVDNSSPPEDSNNRQHRWSSTSFQPAATMATADVLKKVPKMNGTIRGRARQSSSNEADIEAEPARRVGQLDSARSQCETSVYIGMRDSTTSSSSASSSSSALRRPFDHACNLFLHQQALNSSCNLSLSATPTSNNDLLLPSPTTALLHQIGPSQLGSMPLSYGPFGLPQIAGGVPATHQQSLMHFHQQQQPLLDQQQLFQSLAMGHGLSAGLMSVPQSAFEGLPIFVLPHAGTLSLSALQRAAEFKAMALNAMLQQQHGAKVDTSKHFHIFVGDLSQEVDNQMLMEACQKFGEVSEAKVMRDFQSSKSRSFGFVAFTNKEDARRAIEGLNGMLLGRRPLRTGWAVRRSSVGNGGGGQQHGSEDEGLTFEKEHSLLKRGNQQPTLKTVSFESVFNSTDVDNTTIYLGGLPGAVTEEPIRSLFSQFGAIKEIRLFASQNFGFVVFADKSSAAQSILEMHGRELDLGVVAGKCTARVKWGRQPQQPQNGAMANERHGTNSNGGTVPNNTIPTLMELSRQKSAAAASVAAVAVRLAQQQQMALSALAAQQQQIVRFPAGVNHPQLMATQAQNLANGAAGAMAMFGGWGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1R0</accession>
    <name>A0A914I1R0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914I1R0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6076.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6076.t1"/>
        <property type="gene ID" value="Gr19_v10_g6076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000003">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn], chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="14">
        <location>
            <begin position="206"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6076.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="37177" checksum="B2527A632A85ECE0" modified="2023-02-22" version="1">MEQGFGMLLEGAKLLVPAGTATVPIAGTVAVTVAAPVALPVVAPVAATVAAVAGVGAVAVGVGVAATRVAEWIVEEMAKQREKKMARLLQDLQLLTRIPRDYVWVNQREEEMERERQQEEEEMTEEEEEMTEEEEEMTEEEEEMTEEEEKRGCSGDDYGKLVVSAAVGSVVGKLVDKAFDAIGQGKEEAKKQKAFCFLVGDTDSSVKGTITFTQDNVNTPVAIMGQICGLPPGAHGFHVHEFCARSNGCSSAGPHFNPTNNDHGGPNDSTRHVGDLGNVHAGADGVAKIDFTDKLISLSGPYNIVERALVVHKLEDDLGRGVGEKQLESKKTGNAGPCLACGMIVMGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1W2</accession>
    <name>A0A914I1W2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1W2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5844.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5844.t1"/>
        <property type="gene ID" value="Gr19_v10_g5844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5844.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15474" checksum="459C6A83990DD196" modified="2023-02-22" version="1">MDLLRKLEQNRAAIEVRKLKRAFKQFYADSQKYLEDWSEQFLEASEVIGDWVIFESEPTLEKVRKAYKHFFGTTAEELLFGEVAELQQTLKQIEGIRANDQTVDEKWTTIFKNRNFSSLWSKISKRTSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I208</accession>
    <name>A0A914I208_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome activator Blm10 mid region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I208"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6136.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6136.t1"/>
        <property type="gene ID" value="Gr19_v10_g6136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6136.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13907" checksum="F9EE1410721E2A89" modified="2023-02-22" version="1">MSSNSSSTSLKFQRTVWQHRLLPYFTELQEEADRHFCQIKSIAVETLSVSTETVSKRALTNSSSPFSYYFHPSKVGGHTLSLLTFLLKLCSSFLHRVSRERYTARRYRQKVREKMHLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I302</accession>
    <name>A0A914I302_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I302"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6358.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6358.t1"/>
        <property type="gene ID" value="Gr19_v10_g6358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31524">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31524:SF2">
        <property type="entry name" value="PROTEIN CBG10426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6358.t1"/>
        </source>
    </evidence>
    <sequence length="1224" mass="136574" checksum="700F2E07C0625AC3" modified="2023-02-22" version="1">MTSTSDPGGSGSQVPLARGPEAVDSNEGDVKVADLERAQVDLGRMEDKVNRAFRLMNRSVNLKASWVNDVVANSNLNFETVKLQIATLAERVEDLENERNASTREPSLAGSRRRESNTDFVTPQAPRQNEQQGDEGEEEGDNRPVWGLNMLSGGTVGSNLEMFGEESAFAFDEWAERFKDYLSISGKTYTEPEKVTRLKLALKDTPRALFKGLLPAQTATLDSALAALRAKLDSPQRREVAKRTLTLSRQREDESVAQFLRRLTPLVEATNPSLTEAQRKEKVCEEFLDRLKPNMSFLIRLVGLTQAKDLEMVQAQAEELEALLLMNRGDEANRLSQAVNVLNNRPSQTQWNAGPTAGTGANVQGTSGSNVRSFRPFLPPNAQRQQQSFGGGRGGFRNWGRGRQEQFSQRNWSSNPRCHYCQRVGHFAYACQERRNNFQGNRGRPFRQVRWADQQPRQPQGGWQNRPNPINSFEVPALPSNSLGFMENLVQSLVEMNVRNNPSRTAGDEEGQTSGSMNTIAQIEQKKELPEEEKGEGRVEKKEETIPACGPEAAIKHQPKTSNWEGTSLKSKVVSLLSISMMILALCSVANGVEKTELPSHPLICQTQRGGKVWQLPEVIGCSKHAVNHSKSPVPRVLHIFAQNMFEHSVDAWTCRKVRKAVRKYTSITNVPVQEMVEPQMQEVSLSECRQMIEDGKCSLGVLVNESGLLHTDKRIDLSPRMWLVGSFSWTTATSENCYLFKSKVTVAHGESGRIQSSLGPTGNCQFGDGQCSLEDKTRIIWDTNGTGNCEFSEIGTWKGLQLDNVWVSDEVSFRLTFRNESRKVYSCGQGLQKSEEGFAVQDVVIKKGRRTRRSTESLVTESELNAELGYLDEKVRELLTVSFSQMVKSICDYMVETRRWAATALLSDPTAFARKLFQSGKLVAKAAGPELIKVWPCMELGASEYEFAQVGKDADGKPECFDQIPIKFKTKGTEQMAFVNPRTMIVNPTARKAPCAEFQLQFIFVRGVLLEVDQVSAQVKQVKVDRIAKLGDGFPATLTFSRHNFLHLALVNISDVLGQAYEANLARVSELTYKIRSQDTTVIKTLSDQWEEVSVQVRDKIFGDWVRMGQITLAVMTIIVFADFVVRFGLMLRDEYRGRGISNRMAFGAGSGARQVNEPTPAVSAIVIGAEPGVKALEPELKRECGEESGRASVLECRKPLSACCWHVFRSPAHRRRSKRLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I380</accession>
    <name>A0A914I380_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I380"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6460.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6460.t1"/>
        <property type="gene ID" value="Gr19_v10_g6460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6460.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="37721" checksum="481D7EF01CB05176" modified="2023-02-22" version="1">MSLSVSLFECIHRHPDQTARDWAAEDDGENEFEIASVRFYDESPCELCNTSRMWYIIGYAGEEASPSLKDEGVFSHAGFSLGRLLKAVFLLAPDDVHQARKILLAKIGDGNEEFGLFGFEHGQRVPLEQLFPKAAEAAAAVAAGNESDDDAAAAAVVDIADEVVIDACGNGIEREFFSPPPAAAAAASTSFNITFSPQLLFPYAQTPYAMMQNLLTIGGELQPQMTPYFINSPTSAFHPPTNAVALRDVTNYSPISSAPSRTPTPTPFARKRIAHRAHMRQVWRSIDAADRNVEDERPGTASSTSSTSSSNISQTTDARDQRKLALIRQLGKKCQENCRMCDENLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3K3</accession>
    <name>A0A914I3K3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3K3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7180.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7180.t1"/>
        <property type="gene ID" value="Gr19_v10_g7180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7180.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28635" checksum="357F84E7BBD4DEF1" modified="2023-02-22" version="1">MTHYYPPSVEGEPASFAAFPHPQRGQQQQHWTGSLPRLDHLYNRLPINGGEEMPSMMMSGAEHLLSSYLPDVPSTSCQQQQMQSRRCGYSSLPRNYERSWGDQQQQQRQRHYYGAGRPFLPFLLCRLRLFERESGLSREQIFFLLLVILMIYLVTGLRFFCIVIGIMWPIYATEGARRTNDQLALDKWVRYWTVLALVNQMDLCLFERLIPFYMIIKTAILLYIAIPQTNGALIIYGYVMAFFIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4B1</accession>
    <name>A0A914I4B1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4B1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7382.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7382.t1"/>
        <property type="gene ID" value="Gr19_v10_g7382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF2">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037103368" description="Domain of unknown function DB domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="3">
        <location>
            <begin position="495"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7382.t1"/>
        </source>
    </evidence>
    <sequence length="610" mass="65198" checksum="13C933C4682469A3" modified="2023-02-22" version="1">MISAGDRPALHSDQLLLLLLLRLGCQQASSNLLFCCCCARRLRNRKSTSSQPAAGLSQPARANVLSVVHFADQHFDSQWLPQQTASWVPWQQQQQVVQQPWVNNNNHHHHHVDDHHPPPVHHDEDDHHHPHHHHHHFQQHYPPIRNGNNDNQQQQQAVIPYWQEQFSPLGADLAAASSSSPEFQEELPELYKPPIIQHVQTVGQHPQQQQQQNDGSRKTPNGSGGGSVNNAIFTHQQRQQQSSAATGTVQPTGAGLPAQPTGAGPAAQPTGAGLPAQPTGAGPAAQPTGAGLPAQPTGAGPAAQPTGAVSAAQSTGAVSAAQPTGAVSAAQPTGAGSASAAQRAALNNILRRIIPAVRLPPNTAVAAEKDFVANDGGNDGIREVCDETTCTSGASSSEFDLPPPPPPSRFLPDVEKARIAEHLRHKGLSTPRDGVASDAIPSEEPSKFGTLLSTTVPTISTETAATTTPAPARLLTTTTATTPSQKTPNESFLHCCRAKRVPKICESRCNFEVLNKKTLTALFLNTDKCPSEYGLELFTCAAQDSDHSECCKAKRVQRTAAGNKCLAFCNLSPEAPRVQADASYLPCWAVLNEIKNCFRDKLTAHDSKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4X7</accession>
    <name>A0A914I4X7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4X7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6650.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6650.t1"/>
        <property type="gene ID" value="Gr19_v10_g6650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6650.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11360" checksum="A00E715B2FA41162" modified="2023-02-22" version="1">MDMNELKKMSPEQQNKILEDVRREANTQTVLSLVSAFSEKCTQRCITSPGLSLSGSEKQCLQRCVDRWMDSFNIVASTFAVKAQREMSGLGFGSMNEGPSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I560</accession>
    <name>A0A914I560_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine synthase reductase</fullName>
            <ecNumber evidence="5">1.16.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.16.1.8" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914I560"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6713.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6713.t1"/>
        <property type="gene ID" value="Gr19_v10_g6713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6713.t1"/>
        </source>
    </evidence>
    <sequence length="417" mass="45840" checksum="4EBF7BA98EEDA1A0" modified="2023-02-22" version="1">MSELPSLKIGAKKLAQVTELSVPAVTQPLLNINIEQNEQSISADLRALWQCGAAIPTAFGPLVCARVLHNACVSRSDTGRIGKTKWELELALTGKDESREGGGSGVGDVQLREQLLANCDAGDSFNVLFENPEDEVHFVLQRLGLSGEMADTEHRLEVRRQLPESDAKLAHLPSHCSPRQLLSQFVDIRRAPSRLALRVFADHADDAGERRRLLELCSAQGASEFTKFVRQPNISLVEILCKFPSLSPPLGCLIECLPRLLPRHYTLACNLAAQHETIRFRFVYSVLELPAPVLDGCAEFAGKKRYGACSQWLLRLTPGQTVQLVQKEPSKFRFLPPSLVSAMSSSAASDADHHLLLNTPLMMVGPGTGVAPFIAFLQKIRHCIQRVGGGGANCERNVVKRVLFYASSNLEDEFLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I569</accession>
    <name>A0A914I569_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I569"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g672.t2">
        <property type="protein sequence ID" value="Gr19_v10_g672.t2"/>
        <property type="gene ID" value="Gr19_v10_g672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038123165" evidence="1">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g672.t2"/>
        </source>
    </evidence>
    <sequence length="289" mass="32287" checksum="FC59162DDF0B7C1C" modified="2023-02-22" version="1">MGSLCLRLICAAYLLSDALCAVELQFLLLKCRRHQFEKECGTRCANDEQKCECSEEQWQNVQRNCARKFEENRSNCAPHEVRKSARCHERKKPGELCNFTEQCIDDGPAQYFCIANICQVPPECPPGHVSVGAQCFPFAVTGGDCVHPRQCLSGSVCIKGRCRGPCDENQVFIDDGCVDYEGAGCVARACVKHKCPRAFPSCNYVPQKGEYLCCERQIRSTAQCPDPVSIPQLSELTNEVVNCMAEQCEPGFTCQFSNNERGSYICCSVPGQRTGEKKTEIIINKNLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5P4</accession>
    <name>A0A914I5P4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I5P4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7134.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7134.t1"/>
        <property type="gene ID" value="Gr19_v10_g7134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF17">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="216"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="410"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7134.t1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56489" checksum="D2BDB62A0067F005" modified="2023-02-22" version="1">MLFRLSAELDVKRVGIADANGWQHLIAFRKEEGTEMAGLKMIILHRHFIVEDTEDALTEIRFFPSIHHIHHIHFHRKHFFVGVVHHPFNWTPRRARRAKQKCQIVQYSRLNMVVGRELDECESGLGEKQPLLQLDQAKLSDSDPRLCITAKVNCFERKRRRKRLKEYYENQERLLEHYRQDEARLQADSFDADKQFKEQAEQFGRKQRIDRLLARLVFMLNIVLLFVNLAAAVLSGSYAVISAFIDNTMDLTSSAIVQLTVWAIKHTNMFNYPRGRERLEIVAVVVCSTIMGVTNIMMIIQSIQAILSDDVHPQVTLVTILLLVSGIVSKLSLLIICCMQKTTGSRLLALDLRNDVATSLVALAGAYLGDKFWPYADPIGAILVCFFIAISWFANVFSTIPLIVGRRAEQEQTARICRIAIAHDKRIMFLDHVMVYHLGERALVELHVVLDETLPLKVTHDICEALERKIRTLDFVDRVFLHVDYQLDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6P8</accession>
    <name>A0A914I6P8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitroreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6P8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8003.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8003.t2"/>
        <property type="gene ID" value="Gr19_v10_g8003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140616">
        <property type="term" value="F:iodotyrosine deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02144">
        <property type="entry name" value="iodotyrosine_dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
        <property type="entry name" value="Nitroreductase/BluB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026:SF90">
        <property type="entry name" value="IODOTYROSINE DEIODINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026">
        <property type="entry name" value="NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="6">
        <location>
            <begin position="153"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8003.t2"/>
        </source>
    </evidence>
    <sequence length="346" mass="38903" checksum="AF91A8593BF485DF" modified="2023-02-22" version="1">MCQRSSAPSYPQHYGPSPAPPPSSGPVEPGQMAVALVATVVVIQFRVVLKEWMVKLAMALARHLFGAWLNSRRREAGDQQRAQRVGRSSADGIRELTSGQFVDKKVGSDLDAAVEEENDSFIHTQSAEMLYHPSSFGEEEMLRRSQLFYELMKTRRSVRCFSSKDIPLKIVQNIIKAAGTSPSGANLQPWTFCLIKSDRIKRAIREVVEEQEQINYSRRMGAQWVLDVKPLNVNWNKPYLTEAPFLLVVMKHEQAYQLNDTGDRKPTYYSEQSTAIAIGILLAAIQNAGLVTVVTTPLNAGAAIREILQRPINEKVSLLLPLGYPTDECYVPDIQRKQIEDIMRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I712</accession>
    <name>A0A914I712_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I712"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8094.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8094.t1"/>
        <property type="gene ID" value="Gr19_v10_g8094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8094.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30548" checksum="6035302741E726F7" modified="2023-02-22" version="1">MFFNTPWSPSSPPGYQAILIHQEVDGLRHDLSVLLHEEEEPEQQQQQQHQQPWQLYPVETVWLTPRSHRVPRHHRQQQQQQQQQQQPQQNAGDNVLEFAQAFERPVPQRTPSPSNGAPFVHALMHAQPSAVAPTVVEGTLIFSDQCLLCRSDHDSSGNNGGSQVVHRGNNCLCVMICEACVTNGWWQQYVASSAQTAALAIEANLDPYTGLPNEDPESYRNWVEAHDVRPRCLRCHAQRVDFLFPVTRPRRTQRVRSERQCSICRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7I9</accession>
    <name>A0A914I7I9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7I9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7475.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7475.t1"/>
        <property type="gene ID" value="Gr19_v10_g7475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7475.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12573" checksum="58C5FA178036E926" modified="2023-02-22" version="1">MSDAAVLCVPSGGHRNHSVAASKPPQHNWPKSVVEQRHAKRVRMPSSVLSELYPALPTPCFRELHSGPVKVADERERKFQFGPSLFTPKHPFMWTVFFDTFFVYKFMHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I823</accession>
    <name>A0A914I823_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I823"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7503.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7503.t1"/>
        <property type="gene ID" value="Gr19_v10_g7503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF32">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7503.t1"/>
        </source>
    </evidence>
    <sequence length="520" mass="56784" checksum="5F6BCD6B4B4CB1F4" modified="2023-02-22" version="1">MNLSSNSVSFTLWTFYVIASGVFCYDISAVLDNFIIGTPKVVCGESEVALDIITAKPFIGNIFVKGRAKDTTCRQSFSDPALSNGTNTYILSLGKCGMQRLRSANPRGINFAVTVVVSFHPAGFITKTDRAFHLNCFYTEPDEIVTSSFEVSQLPTQELSDQMRMPSCHYSVHSTSVDGAELSWANVGDVVFHCFVTDGDGEDHAVVDEDGCSLDHSLLSEVTYDKDGTMRAHAKSQVFKYADSNQLFFTCQIRMCQKQMDMCHGITPPKCEGGQKLGGGKKRKGKKDGKDKKTGHAHSEDEHRPDEEAETVEGELSVDSDDTVPNRTSTVATIRASETTTVGGNETVVDSTLAQRKKKQQVQRPAVAEEEEDGDEEGQWVLKRPEMALSRKSRSLTQDAGEQLLEVDVASPQMLVLDQEDRARMDPLRRQLATTSASVSANAAQQSAGDISASDALRRVPLLPDQQQQLCLSRAGLVLLVPVAIALLAGLGSALTLCMLHAFARAARGKRRAHWTSTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I870</accession>
    <name>A0A914I870_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7809.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7809.t2"/>
        <property type="gene ID" value="Gr19_v10_g7809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032484">
        <property type="term" value="P:Ral protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042227">
        <property type="entry name" value="KBRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1244"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="6">
        <location>
            <begin position="1207"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="823"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="823"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7809.t2"/>
        </source>
    </evidence>
    <sequence length="1297" mass="142009" checksum="766FC72254D75C5F" modified="2023-02-22" version="1">MRTKVHVVVLGPKKIGKTLLLKSLMSQHESSPCTSAAPTDDRYVPTVEDTFHVQFTDVRLGEQSQRAMLILFHDTAGIANFGNIELRKPYLQVADAFLLVYSVLDPSALSRMEALKKYLEREKVGTSKERKEVPIVVVGTNCEMPGKKVATESALHWANKEKVRLFEVSARDRSSTVELVQHLSERLFHSLKDSKFSLSRKLKPEKSNAQIPENGPDRLNKCSPAHRPARLHNFERFNPNYNLHLLLLPTPPPTKRESAKLLFEEHPMELQKQPVLATKEQLRLAELTQTGNDVTTAHDDIALQKRVKKVIELTRCTQSQAEVALIDGEGNVEDAVSRLLDNPEELVLWSQQGKNKKPKVATSLVASEFKVGQGTHGRRADSQRGRPRQDGMGQQNSGNGGQKQYQPVHSRSSTRSTQPKEPNGPSEGPKTRSERQGFKGQVRTFTGGAFRRERGTKDQSTKPDATNNGNEGAHKGDVQGWTKEGGTGNVGWGDSKGWDDEKKGGDGGDSGFSTVEASYAADTPGQNKDDEWKNGPRVFMPSSTAATVTETSPNNTAKSTSHWPVLDNFAPSEAVETIQQKPKTFAAVAAAKKPQPTTMMPTPEELISTSPSIVFQKESSIPKVSDEPVVEWSSSIDWGNSMSPQPAADRSEFTQHPPDQSASTSTSNIVFGTVPVHSMGTNVNQEYTDQLKSAIGLMTGSQHQIGSGITHQPASASNSCELAADYIQQHNHLQHMALNNTMEMDQSREKFGFHFNSAKGNENSWGHQQHISSPDRSVLKNSTGTMLSTMTSIPTTSSSVSVHFNATSQQAQAIEAHQRISNGATRSGNPLSFSDPASVNFPPSAGQPGGGSVVGHVIPSSFAVQPSDPTPAAHQQQQLHPQNKQMYTPSANPTMITAPPTMQQHLQQQQQQAQTIFHQTSAATAVPQFPNYNMPYMYSPVAAAPALPAPNTELDRFLIQQYGPPYSQLDLQMGAMSIGPATTLAHNHHRATLDSYMENKFGQQQQNVNQAGNNGPYQQSQQSQQQRGLVQSEQTAALLGGPPSHVGPPPGFGMPTAPAQPSYVQPANIHSLFQMPTYPHPYQHPQYMMSNANRLQTAQRPAQTSPPEGNVSNQRRGGTDSQGRFAALWQPHLQPKISLLHVAFGATNDRQRNMSHTPPPPYPGDVTDAMKVPFAAQSHQHQGGIPVYPPPPTFGASNVHVTLPTNVPIVVRARTAPFGPFPIEMDCPYCRNHIVTHTQQIPGALPWVIMAVCFVLGFFLLFIPWCLCCLPFCIDSCLDVLHTCPSCKRLIGRFSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9J6</accession>
    <name>A0A914I9J6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9J6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8757.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8757.t1"/>
        <property type="gene ID" value="Gr19_v10_g8757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8757.t1"/>
        </source>
    </evidence>
    <sequence length="554" mass="61849" checksum="908EEDF37B7189A7" modified="2023-02-22" version="1">MKFDDLITNYVGEFGLYQKTQLFLVCLPALITSMNALSWTFAGADVKHRCRIDSASDNVYWSGPLDAIPRTDCGLSNRSECPFEKCSFGNGKALCTETGNGYVFDRSVVKHSAIERWEFVCDRHYLKAMVQSAYYVGQMAGSLIFGFLGDRIGRKKVFFIAIVLQIIGSSGMALSPFWQLYSVFRACVGFAHPGIFVIAVIIGMELVGPTKRKIASLFTGVFFAVGQVLLGLLAYFVRDYQYLHASIAVFAAVFLSYWWVVPESARWLVSQKRYAEADQILRNAARINKRQMPEKWWDDLDEELNHGGQRENALDGGEKRPIRKHNFTDLLRTPKIRRISFSAFFCWPVVSMLYYGMSMKTDFLGGDMYMTFIFGGLVEIPALFLMYLLVDRIGRKPIISGGFAIAALCMVSNLLLGEKVNAVAIVQFLIGKASSTATYATLYTITPEMFPTVIRNMATGVCSMMARFGAILASLLMMWLVDTYGKVVIIYPFAILGICAAIVVLIFLPETTGKKFTETIDEAEGWTRNQEEMQPLSTQSPQSAKGAAGDTKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA00</accession>
    <name>A0A914IA00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IA00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7981.t3">
        <property type="protein sequence ID" value="Gr19_v10_g7981.t3"/>
        <property type="gene ID" value="Gr19_v10_g7981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF9">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="53"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7981.t3"/>
        </source>
    </evidence>
    <sequence length="430" mass="48828" checksum="8D40691EEFC12F9B" modified="2023-02-22" version="1">MMRLLICDEELSLFDLNNNLTIVLLDTLWSISTLYNQVHCWLGLFICVFGSLANCVHIFVLSRPAMQKCAVNRLLAIIALCDIATMASYTVFVVRFEFAVDKDEPPLGYGFLWIVFLLAHVVCSIALHTITVYLTVITALIRYKTLKRVGSLWNHENIACPIFLMVAVLTVFLCIPTFLIHSIIPVTSTDPITRHNITLFTVGLAEFEQFDTCLFFKLNLWLTGIIFKVIPCVLLLLFTLALLYELEKNHRKRKLMCSGTTLAYRRHSAQSDRTTKILLILLIVFFCTEFPQGILSIMNGLFPNDIHQFVYLSLGELLDLLSLINCNTCFIVYPLISSQYRATLHNLAGCIRQLAAGRGWQAAAANINRSRMSESKFVVTSRRFTLSSSTGSPSSKPSLTFFFVKSNKYSDDIYQQQQEIRFLEGHDLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAR3</accession>
    <name>A0A914IAR3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAR3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9084.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9084.t1"/>
        <property type="gene ID" value="Gr19_v10_g9084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036734303" evidence="1">
        <location>
            <begin position="25"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9084.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="31508" checksum="9F302B290B8B8D4F" modified="2023-02-22" version="1">MTAFANSFLPIAFICLFGLGTVPNSTVLVAAAWTDWKTGKDLGEGGAGDVPITINPAGQIVISAKSMQGVVPDVIKLYFNGSTNDESRKMILNICVLNVAGPIEKCKDGLILCFVGQMDPANAPVITQFQLKNYFENNEIATKCKNAQANWNDNEFEGKTLHGFKIAHVGDTLLSSSTSLETVACNAQNESCCEIRLGEPGILGGFVAGQPLNESETFVEKAWRGGLLRQEDPVSALAFDFLGAIPQGGGLGIIADKCDMQITLEGDGLLKCLGKKCEGNKPGNNSAKAPPAPKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB64</accession>
    <name>A0A914IB64_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IB64"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8275.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8275.t1"/>
        <property type="gene ID" value="Gr19_v10_g8275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036884718" evidence="4">
        <location>
            <begin position="29"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="248"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8275.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="40725" checksum="9FA4B264CB699F0C" modified="2023-02-22" version="1">MAPKLSNSHNELLFCLILYPALIKFASSSAFVPIEEFSTDNEEESVPSIVTVRNGQIRGFRRELEPALDAEKVLFEQADIFLGIPFAQPPVDELRLERPLAASNWTGTLDATALPAPCVPQQLLTALNFDENCLQLNVMRPASVPSGDASSYQFPVLVFIHGGAFIIGGTFVEGTVSIFLDSSRMELNGIRATLAFGTSGKRCCGCATTSARSAALPVRTSNVSFGRSFHYANFGRGAAESGARVARVDHVNKGHAKLLPFPGVAHTAEYAFTLGVPLLGNYALDEEDKNVRATMAHAYGTFVKNGVPNTLNDETNWPRLGSDRRQPLQLTRIKYPKPVTETEPTDVAEKLKFWRKLSTLKGYGGMTGFAKELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBF4</accession>
    <name>A0A914IBF4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7747 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8343.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8343.t1"/>
        <property type="gene ID" value="Gr19_v10_g8343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056649">
        <property type="entry name" value="DUF7747"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24927">
        <property type="entry name" value="DUF7747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7747" evidence="2">
        <location>
            <begin position="7"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8343.t1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52213" checksum="3EFDED0871676F22" modified="2023-02-22" version="1">MDNWYSKEFISSSQTAARLVFNINNCVDLSKVLQLRPNRPPDAKGRESFVYIMDGAVVRSIKDLPIDELTPWNSKKCKSSTRFSSVQFDAEKNSLVFNRYIISDAANVERPECLIACYYCKHPIFNLVKKIYYACDSNRERCLPGTFVIFIYEFAHAEVLYRTYGAYRISANNSMSSTPQQHPSQSMPSQQAQPQPQPIHQQQSNTNSIQRYFENVPLKMEDFIMDDGGGVPTEDSYELDSYLQGTPNTSCLEDILEACNSASLKRSHGTNFSNDSAALLPQFKRIKRSNSEQPDPSNGISPKSGGCLSKLPLDELRTNEGTFGGAVVEGTDAVIGGCLLVDCTFLIENLYFTILWFRNCTFLDPNNSPLIHPIAALISSRIQSDDQQYLINQFSTEIFEGESKGICRSVIVSSDCDDFDSGNFIASALFSYPCVRLLPFDQIKRILHHKVTFLNEEELLFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICC8</accession>
    <name>A0A914ICC8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICC8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g931.t1">
        <property type="protein sequence ID" value="Gr19_v10_g931.t1"/>
        <property type="gene ID" value="Gr19_v10_g931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g931.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45726" checksum="08D279DE4DED00AC" modified="2023-02-22" version="1">MAKTSKTIGTNQLRLLVAAAAIYLLANFDERFMPSFNDVTDNVSYGEFSNCSTNRLLETMIADTHHEMKANIEPAAFTMATYILELSNEAQLQGIHISNQTMLDVCPEKNDSLDPFEKCAFPFALGFRPPKNATSFIMDNGDWSVKLESLLKSMLVTECQMLAQNSKNDLNDAPLVVEEEVKRGCKSLLKGQQLSVDGPKIVGTVTLACQTDGQQMVADLKQWEIDTKKITVFDGLQSAVAEGILPQANEHSKKLLQQFVTLINFLGVVENKMSAGLAKDAIHAVLTQKSLPSEMMQLVIQLWLKVFNGGEHQTEAVQQKQQHQHVQQSHPPGDHLQKRHEFPVRRRRRRQERMLSTARIFRELGTLGMFGDFLRHKMFLILAAIGLYAYLRQHPRFQQWNERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDB7</accession>
    <name>A0A914IDB7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">imidazolonepropionase</fullName>
            <ecNumber evidence="2">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914IDB7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8852.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8852.t1"/>
        <property type="gene ID" value="Gr19_v10_g8852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8852.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31101" checksum="BFE2F15B7BE02638" modified="2023-02-22" version="1">MEGDTTKMLVLHNIGQIVQVVDDDRTCCLLGDQMGKIKIMESDRLDLAILCNEGRIVQIGTIEEISPRFGSTELKDSVSLVDCCGGSVLPGFVDAHSHPVFSGDRVHEFAMKLAGASYMEVQAAGGGIHYSTEKTREATEEQLLQAFLEIAQEMLSSGTTLLEAKSGYGLELGTELKQLRVLERAQAHTPLEIAATFCGAHAIPRGATERSQTELIISEMIPAIDVLRRAGKLKNTENVDVFCEKGVFELDSTRRILEAGKAIGLNANFHADELFPLGGAELGAAIGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDG2</accession>
    <name>A0A914IDG2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDG2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8868.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8868.t1"/>
        <property type="gene ID" value="Gr19_v10_g8868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="401"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8868.t1"/>
        </source>
    </evidence>
    <sequence length="533" mass="57251" checksum="6386D7A428121A86" modified="2023-02-22" version="1">MSSGKFDWLLSSLTPESQVPSTAEIIQKCLSVNPFDLKFREANLQNNGQGGQSGFDRSIGNSCTLPTTSGLGSILNLPSTLSSLSTDIEGELRKTIDLSRKVQQLRENGRLSKQEDGQLKTPCTSDVLNAVLDMQHINGNAAQHNTAGPSSPFISSTSLLAGLSGLKAALTGSVNPSGQESGPNQLVPTSSIPNFKVETDLDHVAIGCSSFTPVGIQGKTMSSPDLHAQSIISSLTPTSKQRHSPVSPHEALLALQQASCSSTFAQSSPGGSGGSLRSSALSPSSLNGSGLTELIAPSRISPMLSGNSGDDPWKIGDGTKQPICPPQISISQQSPYAKGPDSVTSKTSSDMSKDSVHNVPPGGKEKTRKYTKFCIGSADSQVSSTRGGRGRRSIINEMLPDERRHTILERNKAAAVRYRKRKKEEHDDMITRVTSIEQEKNALETQNSVLRRELERLTFLLQERESRCVCKANQLQVGISVLDEDLPSGVVHKGDDLTKFKPKKLNRKLLPPGLRKFFKSPALLFPNFALLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDS8</accession>
    <name>A0A914IDS8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g9920.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9920.t2"/>
        <property type="gene ID" value="Gr19_v10_g9920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05128">
        <property type="entry name" value="RasGAP_GAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF148">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="853"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9920.t2"/>
        </source>
    </evidence>
    <sequence length="1302" mass="146995" checksum="355A7726D44803EC" modified="2023-02-22" version="1">MGKKLQFWTMFDSRPPAEWGAKGRGVTLEMGENEREGSCLFVALLILNFATLSPTPAVNERMIGRGDIRDLSPVCKECISTSARSPSSSHSTIVVDHRSGPGSLPHKAVPSSSSSCQPDFLDLPSVTSTSPSSPVSSSPKWRPAPQCSDARTVPKSAMLMSKCQSFLRSSTASIPPSPSIAKRELTKKAGNDQHHPTPQSPATENENDDRIVRNAGEQPEEEKEAVCALSFARKDGTCHVMSGWPHTPTEHCALRVCQDAVEERGAVDEAAPIGMGLKTDEGAKKSIRGEEEEEEEGLGTSPVADMNKQSQLSRNAKRAARPYRRRDRPPPLPPIDPDPKTSVSFSFAPFLHHPSGGCSSSPSTSSPITNATSPLLRNVPTSSPSSQEKDVQLVVAIRMDRREVFRSCPVLLNGNCCVISEEFSMELPRSSIFHSLQLSLFELTEGARVQRCIGRLRLTRHELVAYGNAIQDRWLPIARIRPSEFTETLGAICAELSWNRQRKMLTLRVFDFTIWTLPTNSNSSSHANPLQRHCNGGGRLYLKCRLGFGHSACSTMQKMRLLERRCVEPVRFDCSQFFADKSGHHQHQHQQQQQQQQQQQEASPRSLEDWMSCRSSCATPTSATAAKEHFRFNSRQFKFPPLSSPAQFHQQQQHKVLKTPKGSMLFGEPHLYIKLYGQPNYCEDSLCGFVHIPLESETMQPRETPQGPNWFNIRDSQLILRIIAKYLLFRPILHPLFIGTAPLPRPQLPPLPSRAPFHTPRWPTSDCNHRRRLSHPFFLLPRYSLASQPHSSSSTSANNQQNIGEIRLKLWYDMDEVHPFVNYQPLYLNLVRSLSVDTHTCSLISLIQCLPIDLENMARPLMKIFVHSKQIRQFFRSICMDYVKSCNDVNTLFRSQSLASKVMYEMMKFFGHNYLVASLKPLVDLIFAERKCCEIDPSKLKTSDSLEQNFRNITTYAELAFDQVVSSLHQCPKALRELFAELRSVVEEVYPNRQDVARLAVSSFLIMRFFAAAILNPKLFALKLETPDVEVSRTLVLVSKILQRISNCVVSVHPLTNKEQWLTPVLQRFSDRDKIAMIQFLDRVSRKEPDEMSQPSEINFVNNENISPVSSSFYETTVLKSGYLIERRCRPVKKSSFKNLIHPKRRFVLLTDASLIWHKNAKDGPASSTSSLMSNSLYSDFNASAEQQKNAKNAFRVTTMNTEVHFQANSETELNEWIILIQKQQRRQLMVLNRSDLNSQVQLQMGAEIDLARELHVIHTNLASHFDKLCDHGWCCRFECTRCDGGKCARDGHTVGMNQRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IE53</accession>
    <name>A0A914IE53_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g9061.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9061.t2"/>
        <property type="gene ID" value="Gr19_v10_g9061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8206" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1576"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1578"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9061.t2"/>
        </source>
    </evidence>
    <sequence length="1597" mass="179156" checksum="AA30168BAEFF6499" modified="2023-02-22" version="1">MPFSSGAQMAFPGGRNDQIQEICVDDGVETEQHQQQTISPTPSESVFSVVTEPTTNDQIHEICVDDGVETEQHQQQTISPTPSESVFSVVTEPTTNGGIGPGNDSVADSLRNDQLSQQLQPTTIAQPTVKKKCLAVVEVEQKNKPTICLKYAFFVPETETVSVSGNKHCNPTVEHMMRTLLPNHLRLSMEQLTENFDLQLQHLDNEFEPARFIDIDPREWGAEWVKNRGEYKVVLHRKLDDDNNAGGISGGGKVVPEKVGDEHRRDGEDVTISEPQKANTKQESFDRFLVSGKANLGNLYNASTDNFVTSDDIKYIRKIFNLRNYTKQSGGGTTIGKQIVEIDDLNSSEERTKMLGPEQKLSVISRLALLDGVSPLGQFLSAAAKQKELSTTNSFGIIQMSLKMISSLNLDDSKVRKSVLKQKDRDDEATHFVGSACFGTLVAAILTFDEQTSLEEAKKLALLHIRGNAMSTSESDALKSLNKSVRISVFVDPTIGAGGTDLDFACGLNLFVDSFKKSSNINNGFGHPITFSLIPLSAIADKKSKHTFRPVPMIEANNIYVQIQSCVQSVEEFELLLKAAGQSQNEYAYTLTKDQLNNAIQMFGDLETKKVAIDALIKKCVIRLRRHPGTSFDATGTEEAEQLSIETLEDAVRQYKTDAGYMLELCDQKLLPKIELTERLKSKGVNYIGGRGTRRLADVFKGNDESDLASALHFVLLYNQLETTPPVVGESSIQNDPERLHNQCLGQLFEKAGRGTSCTYVDWDVLRSYDDFTSIKKELPDDIRALDGFPNNIGIRLVKMRGHKLLTADCVTEECDKFRTYIAWIENSERIEVGAVPPADQTTEACSLPCPRSECYGGKCQNNDFHWGCDACGQTLTFVKQDNVPVTHFYCACGATPVEEFSFRCLDVKTHGNEFEHFAPNALAVELKRMNDKGILNILLLGETGVGKSTLINAVVNYLKHASFKEAIQADKIEWVIPTKFSIVEYADHEFSVKRDVQLGEESAEEQLKTGKSRTKWPKAYIITWKGYKTRLIDSGGILDTGGIKEDDKNFHKTINYSSTFPELHAICFVLRSDCTIAGTAFKYCINELLKYLHKNAAKNIIFLGTKGRGSGYQMVKTLELLPEELAQVESNHKVKIPLHPNRIYCMDNEAFEHLCLIKKANVQYSKKEMDNFSESWRRADQEFQRMLKNVSALEPHRTRETVSLSEARRIIVDLAPALADISEAIQDNLVRIEAYEEAISRGEQEMTTAPVLKTVRRELLPYPRTVCTSDRCTEVKRTEEGDFKVYRRKCHKHCYLEGIPLELCDQEALKYCWAMDGQDKGKCRIDECGCDWSVHMHITFKQKLVPLELDEATRNKFADKSELLNTLTRDKLQIMHERTTIYSKAAPLCGFVNKWALMPSNDCMEPYIKLSIENAKRLANKSEGASDHELNTKKLKGLEESLRLYREQKKLVENAKSDNVNTPSEVTAEDVNKLFEELCELPMFGKSIRQTYEIQQQARLKLQEGYTEKNLVTGLVPKPSRNIDAAGKQAKEQHLNKLEQDGELKSTVKTGTLWNTACYRARHYAGRVPVIGRFVKSQAQPSSSSGTSNRAKKNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF13</accession>
    <name>A0A914IF13_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914IF13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9632.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9632.t1"/>
        <property type="gene ID" value="Gr19_v10_g9632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="404"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9632.t1"/>
        </source>
    </evidence>
    <sequence length="892" mass="102288" checksum="E05A5E1B3FA914DE" modified="2023-02-22" version="1">MNLALNPDNGDEPAYGQIFIVDTEQAMRAIEQANVAYLMKKEEENSELEKARREQREPAEIKLLFETGKQMDRRLGYNVPRANEVAAVYVPGADGEVPEAKIVVRQKGKELKILNSTDAMVTPMTYPLFYPAWMYPVENQGRGLPHIHLLLTLSEHDKLITGEQICYFDENMMEEEIRDKINNGSELLAYFELNKTNVLAKTLLYHQIPEKFCLKKGKWIERKAHFNTIGRMVKVSPAEPERYHLRLLLLHVKGASSYDELKTIRNLDGSVKVCTTFAEACLEKGLIRNDEEWKRALEEAESFEMPWKLRDFFALILVHCNPAKPEELWEMFKESLSEDFSRNFRQEIAYAKAYREIALSIKRAGKTLADFPSMQQINVDEDIEQAFNAAEELDQGERAFDLMYDEQKTVTDEILTRIRNPVKEPAFFFLSGPGGTGKTHVNKTIVHLLRGEKKKVSTMAFTGMAATLLPAGRTLHNRFGLSLDMGNSNISPRSKAWIELKETDLFICDEAPMINKRAMRTLDEKLKEIMNNDIAFGGKVMLWTGDFRQTLPIQKHATRSELVNSTIKRSEYWRTAKKYKLTKNMRALETEQKFAKDLLEIGTGKWNNENDEIILPEGCISNGDLAEEIFGNFIVSENWNEMAKSAILAPKNLDILTGDKAGQTVYIPRITLCCAEEYPFDLHRHQFPLVLAFAMTINKAQGQTLERTLAPPGELLEQRMRTMARTVDFRLWKGIASANKTKQDRAVGASEAQQHCHGLERLSPVTGGTRLIRNQPQLNRHVELLTFMYVEALHRKQPQLDRDVELLALYVEVLQREVYWPTNDIIFFRNDKFGDKHTVMMPPALSRDPHQIFSAIRCSAWQRHVTCCRSSCTYTSRHEETPASGCKFIFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPN2</accession>
    <name>A0A914GPN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GPN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10009.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10009.t1"/>
        <property type="gene ID" value="Gr19_v10_g10009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10009.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32483" checksum="DB08BF4351F7CDD0" modified="2023-02-22" version="1">MSAKTHDFSSWWHYFTRIGSVKSTTAQCKHCDKIIDQGPSKSTAKFDHHLKTKHAEQHKKRAYFLKEKKGKLDLLAQRKPNLAVIFSKAPPEPQLQAPIIPEEPFFSQSQTTADPSAQWSKDGAKTKEADKIVVEWLATDGIAFYQVEKKGFKRMVQFFAPNYQIKRRGYHSEIMPLFYKQLLDRIIADLKKVKFISITSDIWSSKANTHNLLALTAHFLTDEAQPAFVILGSMPVKEKHKTTQVVANYITARLDLLNSKIKSPFGIVRSCIQYDRCFQTNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQ57</accession>
    <name>A0A914GQ57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 151B</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM151 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQ57"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10144.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10144.t1"/>
        <property type="gene ID" value="Gr19_v10_g10144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026767">
        <property type="entry name" value="Tmem151"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14857">
        <property type="entry name" value="TMEM151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10144.t1"/>
        </source>
    </evidence>
    <sequence length="626" mass="71892" checksum="FE20442FB3CD1B17" modified="2023-02-22" version="1">MSSPFETAPTNNKTIRAHRLSVSRLVCNHFHWKCLITSLMISICIAHVLYCQLNGWQNDGNRTASTHLSSSAHSSATNLCSNGYISVISVVLGATFYFIYLSECWHHYAQLGLLPRYSVGQVLELVETMRAAIPVVWWKSICYHYVRRSRRVMRYRNGDAISTTQVYYERVNSNSSGNVFLYDECGYKDLSKRLLDLNQFSAIRMRFSKGFVFACLQAANEFEDQRTRFFAENEMRDDYMEVREGLDLANLPFVERLLVFPERKKRNVPKPTNNAAQNDNSDDNVQLQLPWWLCPWVYWLASLVLCSWPLRLIAECQTARVHFQVTKLFGTNYLSPSSVNYTGALTRTSTMESHELEEANRRNYLIVPSYSEAILLDPMEQNREFLQPANLFRQILSYPRRHVTPTVPGNDTAVHSTYGAIVDHRHRNFRIQKNGGETTAANEMAMTRSQSISFFSEGTDNFCTTNNRRRPQPNHLPCRTRTAFCRQHYQPPPLRSITISEGIDAIPSTQSGPSKATANGANMFDALRAVPKRSQQQRVGTDREPLLEFVRTDLDQLEMHNFTFQQMPAPDEPPPPYELALRYCSPLYQRLRHSVQSLSSTLFQQNSTRDLRQYAMDGPASSSRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQK8</accession>
    <name>A0A914GQK8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the janus family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQK8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10489.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10489.t1"/>
        <property type="gene ID" value="Gr19_v10_g10489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.20">
        <property type="entry name" value="Janus/Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007702">
        <property type="entry name" value="Janus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038596">
        <property type="entry name" value="Janus_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05005">
        <property type="entry name" value="Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143724">
        <property type="entry name" value="PHP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10489.t1"/>
        </source>
    </evidence>
    <sequence length="793" mass="91097" checksum="94DD259471F4B2DD" modified="2023-02-22" version="1">MRKVKTVRGQKVRFCIFKLNKWPMTKIMMEEKWTITRLEKRKALKMFKLSMLRTKSHHPTEALQIAMGAPVMVEIEGESDPLEIARKELKDQKIPIIIRRYLPDGSFEDWGIDELHITDCQTFSMAILATIPNVNIDPEGVFKYILIKASDRKSEKFLVRGYGRCHFHANILEEVTEKEGGGSLQFACVGGGRIRHEPKAKSIFVYGYSQGFGRADHAKSVELLKDHYPDYKIGCRMRFPARGRVVRSLRRCPPSVLAPPLLPILSQSSAVKATSIGLKRARAPRTSLWTWALSNGIEKTSADGRVAHLTSINCGTEVKSIVKLSIPPKAIQNARVTKLSQLPAEAMEALGGIILDCKKPPKMLQNEADELSSTLDMRRFPASPEEVRMARRQIMNEMFEENPALMYQWEDTKERPILSKEFDKEAQKRLAWARYNWKPLKFKDKEASVIFALSRFGGYFAEMRRVLAEFDRNGFVPETVLDFGSGIGAAFWAAFERWGDRVHEYSLMDKDFIIRQLSMDLLRGKNYADSGEMITQNVFFRKDLFPSPKHTYDLVILHRTLIELASQEELRDFILIAGNDFDANKTKELLRKHDKLDQYTIELFADNKVETYEKYCVAREKLPDDVPIPTRLEPGHVFAPCPHDQGCPLLSRSKVESCKFKVRWQEYRADHKTKSVDRDGTLLGEFSFVIMEKGMRKTAKDVPARLLQLNRAHKCVSCRLCTAFDGIQRLVVSKRNEKVYARIRRAMPSQLFPVNMEVVKSEVDLLRSNEKIQRVLPVTLNDDDQIEPIFEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSA7</accession>
    <name>A0A914GSA7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSA7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10839.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10839.t1"/>
        <property type="gene ID" value="Gr19_v10_g10839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10839.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15068" checksum="16C206FFD30FB84F" modified="2023-02-22" version="1">MRSATTSGIGTTSNQVCTDDPTVYEGVQNGCDLITCPAGTTCGIFNGIASLGNGPFEPFQFPKCVSNPLDLSRNTEQNGNVQNIVNGPGCNCGMTQCAVGFQCQVESSICDQLPACLAGTTCVTASGIAKYGNLQSAQFFWPFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSS7</accession>
    <name>A0A914GSS7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSS7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10425.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10425.t1"/>
        <property type="gene ID" value="Gr19_v10_g10425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 15 16" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8 15 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13 16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038172392" description="Zinc metalloproteinase" evidence="13 16">
        <location>
            <begin position="20"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="18">
        <location>
            <begin position="36"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="17">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10425.t1"/>
        </source>
    </evidence>
    <sequence length="536" mass="58777" checksum="1A6DEAFBDDA3E1CA" modified="2023-02-22" version="1">MLRLPPAAICLFLFGLSLGSPKKHRRINPSRWKRQSALTGVQFPQNRWDSNGPIAFFFDESLSEKTRQVIRAAAAFWQNYTCVNFEENGKMPPRVRFYRGDGCFSEIGRNSNQRGIIPFQNVSIGDNCGFFAPVAHEIGHVLGMIHTHARSDRDEFIAIHSENEPNGMEKDFERMSPHNSTNLGVEYDYGSVMQYTGYNQQNGKVIMEAKQPHYQHTMGNAYGPVFSDLLAVNRYFGCGRICLDVQSPHCQNGGFPNPKRCSECVCANAFGGTDCSERASGEGGAPFACGETVQANAQWQTLRGAVEAKADGQLRPAGCHFHVTAPPGQRIELRVEELSGLCSPECNVGALELKFERMTSSGARMCCKSHISEMGMLTTEGPLATASVYSQKGKRTFILSHRTVSPSDAPLYTKWSVSAPPVNESFFYPPPPENPPGECFDWSPNCASNKNACAADRYRANMAKLCRKTCGLCSGESTFGFEATTPEGMKDGNCADLAAGCARIGYLCESGSRALGMAILCEKTCGRCKGAEIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT87</accession>
    <name>A0A914GT87_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT87"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10188.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10188.t1"/>
        <property type="gene ID" value="Gr19_v10_g10188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10188.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12502" checksum="E003776043CD8D5D" modified="2023-02-22" version="1">MHIPRSWDKQSGSSVSITINAKNPQLVHDCEELLCRTCGTSACAFSRSLSQDDFEYAEDLHVFFNEMEKASGTVVPACCYVDEDGIVRMAIRTSSMEIVRSRAITSLRCCMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTU4</accession>
    <name>A0A914GTU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g10350.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10350.t1"/>
        <property type="gene ID" value="Gr19_v10_g10350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="11">
        <location>
            <begin position="1556"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="975"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1122"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="981"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1142"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10350.t1"/>
        </source>
    </evidence>
    <sequence length="1806" mass="200266" checksum="A4FB071E16E98F21" modified="2023-02-22" version="1">MTFAASSWAFWTLSSCSCSTIGVEMHSKQVVGSSFSLLSFATFLFMALVTLAEHPEFLWRRRIPFRVYLQIVVIFFVVNVSNNRVLGFDLPFPLIIVFRSSTLIANVLLTWLLQNRTFSLGRVLSVLLRAAVLDGSDLSDQSPLLSLAMPGQTLSFTFGVLVLSASSFASAYMGIVQERVFMRYGKHPEEMMFVVHFLSLPLFAFVANEIRSDFAEYVEKSLPVDLFIAKVPNNFLSLAAILILQLICIRSVYRLAAETTSLQNEFGMGHAIATGCVLLGSFAFYDGFTRFALSLLAFSIFGGTGSRRAEKTRVKNEGGVTEQQNAISERQPDFFKNPISTINRTMSEVSGGCQPPKKRKIQTIFLGAFNMPQSTSTSIDIKKNGTPPEASLVSDSTQPSPSSSFTSPRNAPLSPSRTSPSGRAGEKFSHEMDEQIAQKCPNLSTSKANCSFEGSSSHNGSATTYEKNGEEQQRLPPLPELNLESTSKLREVPQMCHLQNIAKLELPVPQPQKELELRLKLGFDAQIDRIIVQNSLSNKRTLKSARIIAKFGRETKWCHTVPSPALLIKSNRFWTVLFLEDKTFIVLHSQSGRVSCSLRNQSALALLELRDNFCLAVSTETVAQVWDLQRSRSIFRTSIRSLFGYTTESPRIVHTYVSAKGLPAIVLSSGDAFVYSLPLQSWLSFLVDHELIASKLCSMQLVAKTLPDGLIAALLRASKTEKPSGFVPQRAEMSAAKEESELEMLLRMTRELDSWEEYRFLTAIYAQLLLSRGKCSKLVEFLEELRSLSQTQSELPFSKIAADLSPLIVKEGGIDAERLLSFVNRGQRQVSQILLRTRCSAGVYPSNCAVNSQCARHQTARFPANKKRANRPIVVPLNLVVLWLCREKFLFSFKNTFIIAALTRCFVPELRGLPVDVPTPSREHRRAMPSPAVADPPDCPAVPFGVPAPLHLSNFAMPNSPNFDTSALTTKVGQNAAEEVPSIKDKATGEKGKDGTDTGETAGGAFCGIFCPRSFGRAIDKLLDFVMGSVHSSATASPSVSACSTPTRSREDQSPPKSLEGKIELIVELLERKPTQLAYGMRWAVQLLANATEEEKLEMLRAGVLSRICALITRYSNVEVTVPPESPKTQSLRVSRGSLEGIGREVEGMKTADEKTLIPGATKEGGRDQQRRGSDQPTETSKKRPGSAGSTRKKDGVGYGTGSTKSRWNIARTVEERALHDQHLIGLLSALIAFLWGDQLADRLSEWEMAHAHKGGDRRRSGTALLLEKMPEHLLDEAVTRQISASAVIPLLSNHLSNDSVLDVSQHMPFFQVLLELCAALAAIPALLPKLVLPQGEHGKSIAKELIPQFRDNLNNYPTLMRGISEADLTFMDFIRKINDYSEVIIRVARQFERQIPAEKRIKTSQSHRYFARVGVERMRRLRNLVPTSTGASSVNGAVQSQANGADLQTNVPFPLGQSSAASRGGFGASATVAVAARQRSATTAHRQKTATARRLSTLQLTELNEQSPSEQYREVLREMQLSTYRLLNDAGKPMYGFSFKRELRSVNPFSTTHKDRTKRIAKELASMHNSLPLNDSNAIFVCMDETRCDILKVLVTGPDDTPYENGLFEFDVFFPSNYPQQPPKCSFLTTGAGKVRFNPNLYNDGKICLSILGTWEGRPEEKWNPLCSLLQVLISIQGLIFVRHPYFNEPGFEKLQGTPKGDDLSRKYNLHIENATLNYAIYEQWKNGPPYFADVIRRHFWLKRHAVIRNSGHSLLPDVDGMADGVLSSQSLQRQTVRKLVEQFRDMENPLLADAEEPREGGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GU09</accession>
    <name>A0A914GU09_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GU09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11202.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11202.t1"/>
        <property type="gene ID" value="Gr19_v10_g11202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="8">
        <location>
            <begin position="79"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11202.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39819" checksum="9B3D6BA46A3D1674" modified="2023-02-22" version="1">MKSFIISELEEEEPVKPTSTSSALTKREVKAKVELGVTSKIVYMSNTATSVIRAGLYSEKNLGVHVSAAGSLENAIWNAIEIGCRSFALFIRNQRRWEAKPMDESVVDRWNKAIKETKFPLHQIVPHGSYLLNAGSPDDKKLEMTRKAMLDECRRCERLGIQFYNFHPGSTTGKCTRERSIKTIAETISYVQENTDFITLVVETMAGSGNTIGGAFTELRSIIDQVHNKKRVGVCLDTCHIFAAGYDIVNNYEEVMEEFDSMIGFDFLKAVHLNDSKEGCSSKVDRHENIGKGNLGTKAFERIMKDDRFNGIPMLLETPEGKYPQEMKLLYELEEKELPKKRRMQRADESVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUH0</accession>
    <name>A0A914GUH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10506.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10506.t1"/>
        <property type="gene ID" value="Gr19_v10_g10506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036931172" evidence="1">
        <location>
            <begin position="25"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10506.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24716" checksum="8514D871693313A6" modified="2023-02-22" version="1">MTEMLASTFFFCLILCLTPQAHEAYSPHGSISSRRVLGCPDLEAFQTISSLDHLNSEQLTKITCLCGPEYSNDELLGGKEATYDDQLISITCIYGTKIADLRGTIELVAKSNKSVGRIFLDHVDFAEVEGISSQKGQFLSGPHFADLTQLEIKKCRGNPYLNFEENSIGNFDSLVELVIEECNLEKMPTKLIAKAPKLRRLSLANNKMSALGRADFAGLQMANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV44</accession>
    <name>A0A914GV44_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine specific protein phosphatases domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11620.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11620.t1"/>
        <property type="gene ID" value="Gr19_v10_g11620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="4">
        <location>
            <begin position="75"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11620.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="29983" checksum="36B794839008651A" modified="2023-02-22" version="1">MQFFLPWENDTNGNIQMKESVSSPLLLLRHTTAVGTLPSTNTQNVDKAVASAAGGGARITDLGSQIETLMRCECLTEQEVKVLCAKAREILLQEGNVQRIDAPVKVCGDVHGQFHDLMELFRVGGQVPDTNYPLPQRLCRRGLLFRGNISAAAGAQSALSGQIRRSGPSIGSRMCRMMVQCAICCGADARAFKVKALSDRLFGWVVPCRRQTLDRLRPRNRNETTNCANSNSHLDTLMEEATMSTRSDFHRLASNSSGQLRTDFPICTPKCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVK1</accession>
    <name>A0A914GVK1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11737.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11737.t1"/>
        <property type="gene ID" value="Gr19_v10_g11737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE RDGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="819"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="859"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11737.t1"/>
        </source>
    </evidence>
    <sequence length="952" mass="106515" checksum="85F4E420141AA071" modified="2023-02-22" version="1">MGCGPSTSKSHQHNHHVSGPELPDVHVKVFTYPLPPSPPLVKRNGGKCAVRSPSNSWHAQQPTSVFSSSSNSNRSVHPTSTHNELCKYASSASLGAQNDDARRLPRANTHLPLSANTTQRHSTDATAPSGAVPRAQALIRDEAKRSASEQSLLCRTDIGTPPQQLLQLPGTVLMPPDASEAAQDASGGSAVPTPRSISPLQQQNAAVSRSPSPKRPFNLSAFLSSDQLAADTVSLDSIIGGSNSKLAMTNTVPKSSVPRSNGPTPRASPLHRFRHRQQHRPRSPQICTRRDVCGTAPAFSSQASSCSNCAEHPALYLPTQSDPAILIQKWYRRCLARLEARRRATWNIFTALEYAGEQDQLKLYNFFNEIITAMAEREDLTGRNDICHALARLAFDAADEAEKDAKLWELANPELFRVDKSYKGPTIALPLRSNHVETMIEHFKQNKILPARHLLTILHEARKALKAMPTLTHVSTHMSGQVTVCGDLHGKFDDLCIILHKNGFPSLDNPYIFNGDFVDRGGQSIEVIAVLLTFMVLHPTAVALNRGNHEDHIMNLRYGFVKELQTKYKDSASAIIRLLEDVFSWLPLATVVDKELFVVHGGVSDKTDLDILQQIPRNRYQSILRPPISKLPINLGKKSVDVDEWRQILDILWSDPKPQNGCWPNAFRGGGSYFGPDVSKKFLEKNGFRLLIRSHECKYEGYEFAHENRTKCHILCNTWPAKCTKRSQFVKGLALWNKFGKIDSTGTGRISLPVWCQVVERVTNLGVPWRVLATRLVKLSEDGKFVLYRHHLRVHVGRNNDQHQQFGQDTNGITETLYRHKNTLETLFRFMDKDNSGLVSMKEFMEACQVLGQYANIDLNERSIQNIAESIDFNKDGFIDLNELLEAFRLILGFFSTNFKRKLIFKCLDSCVNAKKAENAVVAFFEQRKAERTTRRECTTAPIKKANVEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVM4</accession>
    <name>A0A914GVM4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10815.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10815.t1"/>
        <property type="gene ID" value="Gr19_v10_g10815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10815.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9074" checksum="37F3CB582B4606D3" modified="2023-02-22" version="1">MFGFWRKLFADLYSARRGESIVFWWFRGSGPKAVPDFGGFGNRSRNREVKGILAHESERMDGRDEKERRFPPWRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVT8</accession>
    <name>A0A914GVT8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVT8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11237.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11237.t1"/>
        <property type="gene ID" value="Gr19_v10_g11237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11237.t1"/>
        </source>
    </evidence>
    <sequence length="588" mass="64992" checksum="99D1A293C5AF2F68" modified="2023-02-22" version="1">MKIKAVYETGQGHKNALSTDRQLFLFIYEKRFPRLSDISPIGHFAHWTFRPLDISPIGHFARGLSPIGSWAKHPGTSFDDGVCLSLPSGACRAVTFPHEHFSHLSPMISSFSPTDKPCSSSSSSSTVPPCCSSSSSDEAEADTRGWPSVNVLETPDRRRVRKTWRSVAIRVDLNRIPESVHHLPSVTNLQRSLPAIISRRQCPTFSPSLRKNGTKRLADTIAFSTGTPISSRQPGTPFTSPPLMRRVRHSPTLRTPKSCNNSSQCGHIHLSISPIGDCSPTSSSSSLPVLRPLNIHNYIGIRFSGEHLKDVTQSQLLNCYSRNGEDKATPPSSTTDENSFVARKRKEQVPSTSFESTKENSSTNDSGFLDSSDFEQPQHPHHLTHPPSSSSSFTIAAPAIPEQSYGPLEASVLDGILNDLSRWPSTDANSPGKTRTSPQRRSLLFERKLRALTIGQRKETPAGKLQRETLNTTRGIPSDLVVEMEEATKEVTWAELELLLPDLDKRSFQLMFGLSPDQHELTYMAHSFIRLQCPQSLPQWSLSENPTLIGHIRSIGLPTDCVTDRIVRLNCPFVTSLGPTHTFLPQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX69</accession>
    <name>A0A914GX69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GX69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11992.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11992.t1"/>
        <property type="gene ID" value="Gr19_v10_g11992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11992.t1"/>
        </source>
    </evidence>
    <sequence length="811" mass="91734" checksum="EDC3A2C64744E18D" modified="2023-02-22" version="1">MPKELICAFSYSAKRLGAAIYDEDEKEVKMVADMAEDADFIVLGRILRQFRPSHVLANRSQDEAFQMQLRTECNYSMSNSSTSTEINQKCSDSVVEDSQEDWTCFNEQTAPTSNDNGVAPLEEDEEGECINLDGFWQPSLNFLPNVAFSFGLARKRLEQIFGGGDNDKLAISFRFDLSSSNMIRSLGALFRFLEQQKAAPSDSGDFNLRSCINGIDTFVLEDCVQVDSVTLRALEIFYSDYNPKSIRQKFVWGNHRREGMSIFKLCNLCRSVPGKQMLRMWFERPSKDRRMLEDRHEAIAYLYQDCNLEVTAHLRTLLKDVCSVRTLCTLVKIGTFFDDKEVNLAIVMGKLHFLGDPLKQLTAILIEVIDFSESSGENRLVICKGVDPELDQSDLDLFAFLPFSDRSVIFLHLPEKELYEKLPEDLTSVARMEAEDIAIESCSVAYVPIIGYLLMAPENMEIPQQTKALVEILFSSEGMTYYKTKRMRLLDENIGDIKMQIVDAETNIVLNLQRRILESKDDVLKAVDLAATLDCLVSLSVVARKYNWVRPKFVEETTVAIEQARHPIAEHICKNGSYVANPVISSNKLGKVKVLSGPNASGKSIYLKMVLYFFYCWPSAHYFLSVEVGSVVYLACCGSFVPAQRATIGPINRILSRLYTIDSVLDGMSSSDEGSLLIIDEFGKGTMTEVGLALLASCLNYWLEGPAERCPHVFISSHFHALCNLLRDPNKLLRFETMDVRRLDDDTLDFLYSLVDGTIDLSYATFTALKMGIPRDIVDRSEEVYIHLRAGGAISELEPVQKFFRYNFFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXN2</accession>
    <name>A0A914GXN2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 15">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 15"/>
    <dbReference type="AlphaFoldDB" id="A0A914GXN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11338.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11338.t1"/>
        <property type="gene ID" value="Gr19_v10_g11338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002164">
        <property type="term" value="P:larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000181">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008349">
        <property type="entry name" value="MAPK_ERK1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01770">
        <property type="entry name" value="ERK1ERK2MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11338.t1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41161" checksum="6E9125F5FFD22031" modified="2023-02-22" version="1">MRLLEYMAVQNPAQHQQPTQQVGPRYVNLSYIGEGAYGMVVSALDTITRERVAIKKISPFEHQTFCQRTLREIKILSRFKHENIINIQAIIRAPSIALMKDIYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVSDPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLNNRPLFPGKHYLDQLNLILAVVGSPSQEDLQCIVNDKARAYLLSLQQKIKQPWVKLYPNADPRALDLLDKMLTFNPNKRIGIEDALAHPYLEQYYDPSDEPTCEKPLMTSIRSANQMLSCCTDDKAAVLRTRNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXR7</accession>
    <name>A0A914GXR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXR7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12165.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12165.t1"/>
        <property type="gene ID" value="Gr19_v10_g12165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12165.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="40802" checksum="D63FA5595E8CED2D" modified="2023-02-22" version="1">MDFGAASGLSVNMLEDLNFLISYTGGEGFQTFRGPALVPIANNVFYYEVKIEECGADAIAIGFGPTDFELDKCVGRQLGTHAYASDGKFLGGPSVDGVIKGKKQFGAGHTIGAGVDLRCTPEKIIYTWNGLLKSGNNLYSTASGRLHSCITLANGQDKSFVSSPPVPKRRNFHLLRKNSLWSNMASNIVGQRRNGGAAAGGGETPEGVPQKSDTLSIAAAAPPAVIVVANGQIEVNTKTLIAAAAVNGVNGGEKVVMNGRATEAAERSPSTIFSDTVPNSPAKKCGPMLGQMASACAIVAALHSLPAPRRRFTAKCPKKKKQKRTTQNIPFPSPPQQQPTLHQIMQFLHKMHSSPHNFKSTIYVFIPPILGQPQRHLTRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYP7</accession>
    <name>A0A914GYP7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GYP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12413.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12413.t1"/>
        <property type="gene ID" value="Gr19_v10_g12413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF127">
        <property type="entry name" value="PODOCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="236"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12413.t1"/>
        </source>
    </evidence>
    <sequence length="452" mass="49513" checksum="1C81CC60342F014E" modified="2023-02-22" version="1">MDPRRRQKADGGPFRLAGTPHGSVLIKQSRSVALFYRGHFPEGGTSATEESVVAQRPSAAHTAEGTLSSCSSSSSDSLSATSSSPSTSRRASTYRPSRTKEYAAEEEGEGEAAEETFPLMFYQQQQQEAAVGMLGPASAGSSAIPIIITGSALNTPRPSQSGGGGRPRMGRRFTLNPLIFAKEEREMRRQSLAQLKLSYYPKNADYDDTSSWVCQWMFWLLSWILLLLTFPVSVCFCIKIVKEYERAVIFRLGRLIGGGAKGPGIFWVMPCIESHVRVDLRTVSFSVPPQEILTRDSVTVSVDAVVFYRILNPTISVANVENAHHSTRLLAQTTMRNMLGTRTLSEILSDRDAIAMAMQTLLDEATDSWGIKVERVEIKDVRLPLQLQRAMAAEAEATREARAKVIAAEGEQRASNSLREAASMLESSPAALQLRFLQTLNTVAAEKNSTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ71</accession>
    <name>A0A914GZ71_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ACB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZ71"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12542.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12542.t1"/>
        <property type="gene ID" value="Gr19_v10_g12542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF120">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00059808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12542.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13327" checksum="C555BA8F2DC0D8BA" modified="2023-02-22" version="1">MASSPDERFNAAVDIVQKLPKEGPLQTSNDQKLKFYSLYKQATIGNVNTGRPGILSPIERAKWDAWKAVEGMSSEEAKEKYIETLLAKFDDAGTQVDISDWLSKIDPSIRTNLALLGKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZA0</accession>
    <name>A0A914GZA0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 15</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZA0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12169.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12169.t1"/>
        <property type="gene ID" value="Gr19_v10_g12169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048386">
        <property type="entry name" value="Med15_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21539">
        <property type="entry name" value="Med15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARC105/Med15 mediator subunit C-terminal" evidence="1">
        <location>
            <begin position="290"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12169.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="45359" checksum="881776A56F46789F" modified="2023-02-22" version="1">MDYKAAAGLSVDILENLNFLISYTGGEGFQTFRGPALVPIANNVFYYEVKIEECGADAIAIGFGPTEFELDKCVGRQLGTHAYASDGKFLGGPSVDGFIRGKKQFGAGHTIGAGVDLRCTPGKIIYTWNGLLKSGNNLYSTASGRLHSCITLANGQDKIRTNFGPNFMYPLASMGIHQMMFDPNMSYGPQQLSMYPQQQQQQLRFQQQQNLMQRQRTMAAGSGAIPTNQPHQQKAAFATAQTAQNYAGMVNTSSTVLTDAGNVAGPSSCAVVQNMLNCPSGKVTVNILQLPELVQSEISGMEQRFHFDPNVALCPDSNSFIINCILKREEVPSLRLIVPRNYPAGTVSVERVVLDLNWFSFDDLQREIYEQLDKQPAQGIAGILNIWDTTVQQFYSGQMPQASYQDFGGFSSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1F9</accession>
    <name>A0A914H1F9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1F9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13041.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13041.t1"/>
        <property type="gene ID" value="Gr19_v10_g13041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13041.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24467" checksum="9F250B5C50AAC547" modified="2023-02-22" version="1">MENAVSVNVKLEETPLKTFDEIFGEGWWDKDEAEDLKIPPTTNFGQNVHHQIDRQNTQIGQIEPNSIDQNPPLTESDHSDNAKNGEEMKKNSTEKWKFDQMKAELMRDGFKNSYHQEIDKTVAKELGLSLATIYNWKRELGQSKPQHKHSHSEQMKLTKRYYEIKHKTPKIRDVDIAKRLKIGGRTLVNWKRQFKRHQLHQNSVDGHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3D8</accession>
    <name>A0A914H3D8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13474.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13474.t1"/>
        <property type="gene ID" value="Gr19_v10_g13474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13474.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40387" checksum="C5A63F8045A386AD" modified="2023-02-22" version="1">MDGYGISDGTEVGQLTINRTFLHLPFSSSSSSILLFFIFHSPLLHLPFSSSSSSILLFFIFHSLLLHLPFSSSSSSILLFFIFHSPLLHLPFSSSSSSILLFFIFHSLLLHLPFSSSSSSILLFFIFHSPLLHLPFSSSSSSILLFFIFHSPLLHLPFSSSSSSILFFFIFHSPLLHLPFSSSSSSILFFFIFHSPLLHLPFSSSSSSILLFFIFHSPLLHLPFSSSSSSILFFFIFHSPLLHLPFSSSSSSILLFFIFHSPLLHLPFSSSSSSILLFFIFHSPLLHLPFSSSSSSILLFFIFHSPLLHLPFSSSSSSILLFFIFHSPLPPLPPPTPFCANQFAFPSFAKFDLISPARLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3N1</accession>
    <name>A0A914H3N1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3N1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13546.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13546.t1"/>
        <property type="gene ID" value="Gr19_v10_g13546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13546.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43886" checksum="A5F65CCCA1E11E51" modified="2023-02-22" version="1">MFKYRRLREEKEEVMGMDEREEEGLDLAGPSSSSPKSRSPRSSSSRLSHSQQQQKAEEFHSQFSEEDFQLELRQFGAKVLGPGGVSLPRRSELWRLLDSGEDAISVMCFTWNIAGKAACSLPQLNSLFTNMCPRERPSLIALALQEVPPSTLKFHASVVQQIGHSLDSTHRVFCWVRKWSQMLVIFVRHRLALFTSHPEYRFVAGANIARPFLPLCVHCVPSDARKSRLSHFGLSQNGDEYANVFWFGDLNFRVHRVADVEKIARSFEQKTFWRPSDFVHILAHDELSAERQKGLFEGFCEGIIRFPPTHKFLIGTNLYVPNRMPSYTDRVLFRSLSSDSSQYLVPIRYDCVWDVTCSDHKPVYCTFRMSVVRKKKGQVENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H526</accession>
    <name>A0A914H526_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H526"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14238.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14238.t1"/>
        <property type="gene ID" value="Gr19_v10_g14238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14238.t1"/>
        </source>
    </evidence>
    <sequence length="552" mass="61069" checksum="2DBB6A04C8359FC1" modified="2023-02-22" version="1">MYKLCCSGNGEYQGGKVPKDLPLMIDLRFFYSVKMAVVFILMLLSSTTLKAQRNENDKFYDLMAAIGEHFGGELNKAEKALELDLNESELSIFDYWIEIIEMKTKNTQKPIFGVAIYSEKYDGFKSEGSKERAFKLSRENYKILKQLNDQKFSIYESLNLLKAAFNWAYSPTRRIDPELHFDSQDKEIQQEVQKDFEENCKKFENEEEKIMFLNNVHYELAINFEFNHRKGKEQQEHQHQHHQQAQLKQAKKVGDSRRRRRPGAWPTRAIGGMEQECEGSGVQRAKIQQGQVVQRGQAFVRTGQTGTGEAGQWGFSGVQLAEVHPGQNFLQHGQFRFGQAGIGGSGQTGGQGGGGFQLAGIQASQNFIHQFEVGPGEGGQHGVQLAPGVQLSHGIQHGQNFGHHRQHRPGGGGQWGFGGVQRTHIQHGQIFGYPFDVGQAWPVGGSQIALGVPMEHGVQMAHGGQHGQNFLHPIVVGQSEQVGGGQMAHGDQHGQNFNSGQPRPVEGRQMAHGVPMVLGVQMAHGVQHGQSEVGQAGPVGSGQHEVQMAHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5M8</accession>
    <name>A0A914H5M8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5M8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14052.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14052.t1"/>
        <property type="gene ID" value="Gr19_v10_g14052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037712247" evidence="2">
        <location>
            <begin position="28"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14052.t1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42858" checksum="8ED7BD3DC6CDD412" modified="2023-02-22" version="1">MIDFCLFYSAKVAVVFILMISSPTLEAQRNENDKFFNLMAAIGEHFSGEFNEAEKALELDLNGANSFLGSLHAFATLEIVTKNENGEFECIASNELEALVHGKNFDGTLKEKQENSKEKIQTFLAVSKCFILPEWELSIFDYWIEIIEMKTKNSQKPIFGVAIYKETSNKYKNENKEKAFKLSKENYKFLKQLNDQKFSIYESTNLLRAAFNWGDKGIDPELHLDSQDKKIQEYVQKDVEESCKKFDNEEEKMLFLNNVRYDLAINFEFNQRKDIYDRAEDLLSKWVGHRDLSIYGIEQISEESYLKKNASQMLRTDGRKGCRKKESNGREERIEGRDARKERKEDMKEGEVEERKEEGRRKEEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5Q5</accession>
    <name>A0A914H5Q5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helitron helicase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g14422.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14422.t1"/>
        <property type="gene ID" value="Gr19_v10_g14422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="839"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1829"/>
            <end position="1855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14422.t1"/>
        </source>
    </evidence>
    <sequence length="2335" mass="263242" checksum="475F4648C1C4956E" modified="2023-02-22" version="1">MNHTKWTFFPPGEYSFFVVHHFGWTVVVAAEVAHLNTAQHRVNMLFFLHVLTQPRIGKQHLKRLQLISAPLLSVVKHIPAGGNSFDSVFRKRGRPSACADQSEDDELPIEKLRILSATVDHGIGLNTLHEDTLPSAASELQAYENVTAASDFIGPGQQEMLHDLGIEPCELQKECCPKPRAARGRFAKSMSCVFCSFPVDSMQGYGSFECGHKYHWETQFKEWLSNEATKRCKHGTKCPKSRPSMRCPQCKQQLGVGYFETGCYCSETLRATDLHADELEEKLCSNGGLCLQCSTPHPGFCNICNMLFSLTDEGLPPTKVFLPCCLTYCHQNCWYEPEPNQTCPRSCGSPWKGVQDIDYIPACHVIEPAQQRQIAKARGCFGGRPVRPEQRTRPSSALSGMFSQSTLDSVLMPPPSLAPRRSQRESRSTSRFSSEMWSPQHAVFEPITNQCATPHSKHFGVGCGACSAKHLPDYYDSLAEPCTCPFCGALCLHSEGTGPTAFAKCCAKGRVDLLVRFNDLQNRPGELMALLYNHDTGIVRMRDALFKNALAYNSHLSFGQIQLQLSTDKRAYDKRIIKCNNMMQFAVWDFNPPSSSLPALHGQLFTIPPADAQTRLSEISTDHNLSPELMEFLFDVLRRYHPYAALYQTAAEMFRQLPQQEQVNLRMLFVDSTPHGEERVFSDDVVRPAPIIAPADLQNVQQIHPGRLGVQTVDGSRLVAQFYLDDGSNVVPSNPYDVVLTGRFGSGKIHMKWSNRNIDPVLFPLLFSRGQCGFALRLREGEHVDSHLLLRDAQQNIVPETDELGEEAEFLGPTNERVYNRRDKVSFAQWFRYMSQIRGANWRNPHWLWDWGTIAQLYTLTFNNRAEAQKVQYMKRKQGQRRLVLPNSLINWLEALRNKQGIDKTISQQTYRSLRLARPHWQFYQREYANCMTICREFGPPDLLVTFTMSPDCPELQAMLGMREENNSSGLTAQILCAGSSWTNSKNFTKTSPNAAFSVLFVLEVEVVLNPYSGLPHVHTAIILDWDRMRNMGKIQTPADYIDEYICAEIPPNPTGRTKEAAQQRALHKTITTKNIHTCSTKHCLQDGKCRKHFPKPFEYDNVHSENAYPRYKRRPPPPSIQEAQQNPQLYGREIQYKDQRGKTIRKDNSHVVAFSPFLSSKYVAHINVEFVAGDGCIKYLCKYMMKGADMAFVQVTDGNTGQSALNYDEMHQIRLARYISSMEAYLQQLGTPLIRRSHQVDELDVHGPQGHRIAVQQGFEDEEEQRNAFCEAAQAEEERRNAGEERVTQLTAYFAFNEQCQDDALHLTYATAFKKLWYDAAKKEWKHALSNNKLGILRQYANCCSTSKTRPAGFTSERLTPPTEILVFVSRCAKAFISVNSVTFFGKHDLLYCPKAASLSFVISSLTFLSSANCGAAQSSAKLKRSSQSAILLSSAGSKHSTFGSDVVVAAEVAHLNTAQHRVNMLFFLHVLTQPRIGKQHLKRLQLISAPLLSVVKHIPAGGNSFDSVFRKRGRPSACADQSEDDELPIEKLRILSATVDHGIGLNTLHEDTLPSAASELQAYENVTAASDFIGPGQQEMLHDLGIEPCELQKECCPKPRAARGRFAKSMSCVFCSFPVDSMQGYGSFECGHKYHWETQFKEWLSNEATKRCKHGTKCPKSRPSMRCPQCKQQLGVGYFETGCYCSETLRATDLHADELEEKLCSNGGLCLQCSTPHPGFCNICNMLFSLTDEGLPPTKVFLPCCLTYCHQNCWYEPEPNQTCPRSCGSPWKGVQDIDYIPACHVIEPAQQRQIAKARGCFGGRAVRPEQRTRPSSALSGMFSQSTLDSVLMPPPSLAPRRSQRESRSTSRFSSDVWSSQQEVFELITNQCGTPHSKHFGVGCGACSAKHLPGYYDSLAETCTCPFCGALCLRSEGIGPTAFSKCCAKGRVDLLTRFNDLQKRPGELMALLYNQDTAIVRMRDSLFKNALAYNSHLSFGQIQLQLSNDKRAYDKRIIKCNNMMQFAVWDFNPPSSALPALHGQLFTIPPVDAQTRLSEISTDHNLSPELMQFLFDVLRRYHPYADLYQTAAETFRQLPQQEQVNLRMLLVDSTPHGEERVFSDDVVRPAPIIAPADLQNVQQIHPGRLGVQTVDGSRLVAQFYLDDGSNVVPSNPYDVVLTGRFGSGKRHMKWSNRNIDPALFPLLFSRGQCGFALRLREGEHVDSHLLLRDAQQNVVPETDELGEEAEFLGPTNERVYNRRDKVSFAQWFRYMSQIRGANWRNPHWLWDWGTIAQLYTLTFNNRAEAQKVQYMKRKQGQRRLVLPNSLINWLEALRNKQGITEKSLSKHIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H748</accession>
    <name>A0A914H748_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g14624.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14624.t1"/>
        <property type="gene ID" value="Gr19_v10_g14624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF3">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037962828" evidence="2">
        <location>
            <begin position="20"/>
            <end position="2421"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="55"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1618"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1969"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2399"/>
            <end position="2421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1481"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1518"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1640"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1678"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1751"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1982"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1998"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2045"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2085"/>
            <end position="2095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14624.t1"/>
        </source>
    </evidence>
    <sequence length="2421" mass="279178" checksum="91D9BD24993550E9" modified="2023-02-22" version="1">MDLLLVYLTIITLSGSSVSNKLPQLEQDENTNVQLHDSVPSDLVPWITGPRKKKYQFNIGKQSWLAAREKCLAQNADLVTIESTEELQWLLTHYKPQLPHLRERQVQVGLLLDSPISNSKQSAAAWRWVSGKLLDDQSIMHWAQGKPFENANGTERCALLNINADAKIDDVDCDMGAGTESNYRFVCERTHEKHIEQESQNNPLWKKLEDILTFFGISGPESDKILTNRTNGLEEEGYWDKVLATSDAFKRPRNSSTEPGELPEKQTNEINLIAGKKPSGIIIENKMASNAAELADRILEGKNEKIAHDEQRQNANETQNAKKEDFDSKSELSAKNNDDNDKKLEAKPPVLIEKIAVGKIVASPSSIQAQLIEPKREELLVDKAGSLLLDKAQNTVTSAASTDNDGTSVDQKPATEELDGQNGTKLRAFRTRLLTEDPEQGKNKKEEEKVKPADARKESIRDGDENAKAKTPEQTNAKTEEQIKQLNKAQKEVINAEEINDQDSKKPKEEEINDQKPTEEIKEKLKDEIKEKPKEEIKEKPKEEIKEKPKEEIEEKLKDEIKKKPKEEIKEKPKEEIKEKPKEEINEKQTEEIKAKPKEEIREKPNEIKENPKKEIKEKPKEEIKEKPKEETKEKQKEEINDQKKPKEEIKEKPKDEIKEKPKEEVKENPIVESNNQKKPTEEIKEKPKEEINDQKKPKEEIKEKPKDEIKEKPKEEIKEKQKEEINDQKKPKEEIKVKPKDEIKEKPKEEIKEKPKEEINAQKKPKEEIKEKPKDEIKEKPKEEIKEKPKDEIKEKPKNEIKEKPTVESNDLKKPTEEIKEKPKEEIKEKPKEKTNDQKKPKEEIKEKSKEEIKEKPKNEIKEKPKEEIKEKPKDEIKEKPKDEIKEKPKEEIKEKPKDEIKEKPKEEIKEKPKDEIKEKPTVESNDLKKPTEEIKEKPKEEIKEKPKEETNDQKKPKEEIKEKPKDEIKEKPKDEIKAKPEEEIKGKSKEEVKENPIVESNNQKKPTEEIKEKPKEEINDQKKPKEEIKEKPKVEIKEKPKEEVKEKPKEEIKGKSKEEVKENPIVESNNQKKPTEEIKEKPKEEINDQKKPKEEIKEKPKDEIKEKPKDEIKEKPKEEIKEKPKDEIKEKPKEEIKEKPKDEIKEKPKEEIKGKPKDEIKEKPKEEIKENPKVDIKDEPKEEGNEQKKPKAEIKEKQKEEIKENLKVDIKEEPKEEGNEQKKPKGEVKEKPKEEIKEKPKDEIKEKPTVESNEQKKPKGEVKEKPKEEIREKQKEEIKEKLKDEIKEKPKDEIKEKPKDEIKAKPEEEIKEKPKVEIKEKPKEEIKENPIVESNNQKKPTEEIKEKPKEEIKSKPTELISDQNKPVEEIKDQMESKKEAPHTQTSFKAESSAQEKLNEELKLAQEINDQLKPTREFEKHSPNEVINDQLIAQKEAKNDQDLLKEELQGQKAAIESTNDQKEPNETTSEQKKPAEEPTDLNTTKEQITDQTLRSGINDQNPSGDELEYSNKPTKQINDHIDKQEKPREKIREHNNMKQEIKDRDLLDNHVMPSKLKKSFDPLFAVAETLERSMIGSENEKTRFANEVEAKSGLVPDQIQHLERIISAVQRMMGLGVPQTSDNGIPSKGVQRNEVAEEDVLKQKKPERPADLFKESAKIDDKGVEEERVDKTRRKEKKEESEEEKEKKEEREEEKEKKEEIEEEKEKKDETRRKEKKEEKEKKDETRRKEKKEEKEIKDETKRKEKKKKVMEEKEEKEQKAKEEKNSNENERTETKKEEAIKDADDKQARINAKKEAIEAKKEANPKDTFDEKVIPPPPPPSNELAQPKWRRRLFGSRVVNTADGSATDVADTASRNRGDDELLDTDTLRTARPRDRHVPVLNIFDRATDLYGDLFRMMIDPEGIGGVHGIHPQFVERLQSNKSDDLNALHETMMALEADFEEAERDAKTHPGINGGDLVHNIIFPEPDGTALDACQNGTEQDDDEEAVHDDEAEAEQWKSKLTDKLEPFGTTKKSENEVNGHEELKNATKNSETGVEGDHLQKSTTTTKSENQLADHEEPKIPGNLTKTTENEVDERHKMPSITENSAISPENGTLLAKSESRLEKYGRKAEKRGSTEVITSDGTLQGIRLSADGPSNGKIHDGDEIPITEEPPSAKHAEHVVERGELKSEKIRDGDEFLDALNAKETFDGKSSTVQQLAQKVKIAAHIEPKANDDWVLPLNKSEQETNEAIGIKSSSSINNVSPNLTSIDNVSPNLTSIDNVSPNLTSIDNVSPNLTSIDNVSPNLTSIDNVSPNLTSIDNVSPNLTTSSSGVFPQLNFDLFRYGKVPPEIERRHGEERARVDNVYEQFRTKESVYDLIRRIQQAEARRLIVKQSLPSPVDKFDVNRNSADRTEYNVDQQGNESGGFITENPFYVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H795</accession>
    <name>A0A914H795_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H795"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14664.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14664.t1"/>
        <property type="gene ID" value="Gr19_v10_g14664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14664.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9803" checksum="AC180D0C82568DA1" modified="2023-02-22" version="1">METLIEMDENGLSLISGRLKESFKKFYSDSLGYLDKWLGFLAEYEDFGWIAFEEISFDKICRVARMHRTSWTTCLTSCEKRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7A5</accession>
    <name>A0A914H7A5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g14488.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14488.t2"/>
        <property type="gene ID" value="Gr19_v10_g14488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1182"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14488.t2"/>
        </source>
    </evidence>
    <sequence length="1544" mass="172364" checksum="8FDA47997CBF8834" modified="2023-02-22" version="1">MMIVPKTTKTLSPAFKGYHVIINHFVKNGVLVKRVEAFGREAVVFHGCSNQTVHRYSTDFDLINALFVTFSSKTPEDYLCLIGSTQIDFYALADGMYCSLALPFKICQANSVSFGLLLERNSLPGEFGSSPCAAQLFSLTHPYNEIFPILCKFKDDSHCHYTFRGRKMKVVPKDVGANWTSSFFGPNDLLMCYDFDERTNHIFMIRKCTKDERMAAKSDFGVMNSSALLHTPSSMQSFYSPNFFNRRFIENQMIGATNAQHYSPSVAINPITFSNNTSLSQPKYHQQNLANTSNGASVVGFASKVTPVRRYYTRSIAAAERLAFGINSNTFSAIFSQPSTTEKSPALRSLEHSATLNRMKLKQKLAMVASGSSLYTPRQVDMSDLLSFGERDGDGDDPPASLDMAVEFCLHWLWAESTEKVASKLERLRVSSSASSHSEDKSEMSRMASTFFISRNLFDKNDRYIVFHVPHERRVRILRLSFGKGHRNLSFIHTPILSYCAYSSATAAASIRGSAAVPFLHASYFMVLECLNLSEDQFCLPPSVALYHGHHKLAMIALNIGPNAHLLRLLPAGRCPKGLNLFYLQVITADEEDINSETNFSQIETQNSISELQLGFGTEVANRCFYAICVTLQSEHQLNIVSRSICTNPWRIVLEAEQIPCVNELPADRVELALLFELLFNNFGVELSTELPYRQLLGRIREHMGEDLQGGSVNKRTRLNDVTAELTENDEFWDKLQADMNLIHSTSDLNAKCIRHLYQVKILERRVLNFLRKVVDRDSGQRKCKRAREVVTATRHRLGAAGAFDCKRNVADVHKWVTASRWMMDLRLHNVKHMLDPSLPILIPNKAFGMSFNDVQQREQHEQFLVSVAIRTLARPFGQALLHFRTRHGFSANDLDPAMGMRQICLNGRVHPGRNQVDYPLNESFPTHKTAMDWANFYNALARGLSFCGGFPQCLFSNGPPENELPSTVRAGLILAAGLVGNVRNVMNLYDIHVLLTQNNRHLVIALLVGCAAAYRGTSEVHIYKIIATHLPFLLQPTLCEFRIDLVVQTAALISLGLLFCETSNHTVSSQLLNQMSLEVPCESDQSSDRYAFVLAAGFAIGLINLGKGKEISDTEIPISSSPSLKDRLIKLLKGGERRMAYLNYDHVRCSCMRVNNVVGPRMGGASSSVGRTYTPGGGGIHGAIESLNGGTHDNGGPSGQSVPRHVDHSGIGQPSSSHVRELPTLNIHLTSPSAAIALGLIYLRTGDSWISDTLAIVDTFYEIDQIRPDMLMVRTLSRCLVDFDEIKCTQEWIETQIPEIIRKYAKHFLEIKSKEEMWWAEFIDMNTVAKAYFYCYAGALFALALRFASKWDIKALRLIQHFYGMTQIDDAKNATSSDGHSMADFAIQAGKNCINACINVSALCMALVMAGSGDLQTTRLLRKIRNTFHKIGEAPIPRDTSVHSLHVSTNMALGLLYLGHGRLCISNSNLAIASLVISLFPLFPHSIIDNRFYFQSIRFLWVLAISPASRCEIVHDGLETGNTFAQRTVDCPRCGNITVNKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H908</accession>
    <name>A0A914H908_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H908"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14362.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14362.t1"/>
        <property type="gene ID" value="Gr19_v10_g14362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14362.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9298" checksum="E1E473285C09E0DA" modified="2023-02-22" version="1">MMLKEMNFSSDGCEIGIAIRSSKGEVIIKVGVIKSIKHYDRDLKTLAGHSRRKGVMETFWLLGHAENGALPANNAQDRPIDDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9L5</accession>
    <name>A0A914H9L5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9L5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15061.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15061.t1"/>
        <property type="gene ID" value="Gr19_v10_g15061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15061.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19937" checksum="BA90190BEEBABAB3" modified="2023-02-22" version="1">MKPTKIWKGRQQSLDKMSIIKSTDRTPKLDKLNPFQLTNLDKLNPIQLINLDKLNPIQLIRILHLSQSLITLRMRKMGKNLLLKMSENRNLNAFVQMSLAALSSQSIIMNLGVELLRMQIFAVLQDAELVLQFADQAVRVAVLLAKQTDCRVVLRSVDWQSDDDFLRFAGQHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9T3</accession>
    <name>A0A914H9T3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9T3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15373.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15373.t1"/>
        <property type="gene ID" value="Gr19_v10_g15373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15373.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9181" checksum="E8F0E8C280FAF828" modified="2023-02-22" version="1">MRRACSAVNSPTSETSRLGFVSTASCSCTGGSGGGGSGPYLTAGGWSCSPSASFEDFFRRICEHREQRSTAVIIVAISTANCVRPNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9V1</accession>
    <name>A0A914H9V1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9V1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15133.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15133.t1"/>
        <property type="gene ID" value="Gr19_v10_g15133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15133.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="24578" checksum="E9BABA49C8ED78A4" modified="2023-02-22" version="1">MTVVTRSCAGHDLVVTRSENSSGRQGSPAGVYAERVSGRQGSYTFGRQGGVRQPKRNYAGFKMTTTPEPIAITITITTPEGVAWSAVSNTGAEQAQPQPQQQPTTSGALDGALFDTDPNDVPITPEPGSDVHRPLSASTPRRGHPLCAREPAVDAPIGSHRSRNRWDDPTLNYYLRSLHRRTEGVGSAFSRGRAAAMIAAADENSPIKTMSCDAINSRLRRLFGRKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAE3</accession>
    <name>A0A914HAE3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">triacylglycerol lipase</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HAE3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15540.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15540.t1"/>
        <property type="gene ID" value="Gr19_v10_g15540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000003">
        <property type="entry name" value="Patatin-like phospholipase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF41">
        <property type="entry name" value="BRUMMER, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="13"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="46"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15540.t1"/>
        </source>
    </evidence>
    <sequence length="545" mass="60757" checksum="88856F37706D1B5B" modified="2023-02-22" version="1">MDHRNTCFSNANLSLCGCGFLCIYHAGVCAALREYAPQLTRNRIYGASAGSIAAAGLICNVSVAEATTAILQVVAEARSGVLQAFSPTFDLMAIVRDELDRILPDNAHQLCTGRLFISLTIYETGKNALVSEFLSKKELIQAILCSCFIPIFCGYAVPEFRGVKYIDGGFSDNQPVYDQNTITISPFSGESDICPLDHASASIIGFVYYNTSIRFNNENFYRFCSCFVPPSQEICSKICRQGFTDALRFLTRNSITPCTKCLSAQSTELNMSEELKRSRSYFNIQQATANVTTSRRRKKLDSECGVCMARLEQRLSSDMTTALFPEILHKTLQEPITCSSLPVQLFRYAKTFRAVNFGLRCFADPLFRTFEYALCVLRMLNEWLLRAKKTDLILNRLQKFIDFLLRQADEKNLWSNPNISCQYQFTASRASAKDAYNENSLLAELFDDSYESLTNHSRRHDLLLVNYYCKRSENNNSSSEAFAQSMRELELQQSSGGRSDGVGLATVLPVVGEAEIVTPPVHLVPQNGEKDSGTASADDGGNDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAK7</accession>
    <name>A0A914HAK7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAK7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15746.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15746.t2"/>
        <property type="gene ID" value="Gr19_v10_g15746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056314">
        <property type="entry name" value="AP3B1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029390">
        <property type="entry name" value="AP3B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14796">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24080">
        <property type="entry name" value="AP3B1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01355">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="809"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="848"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15746.t2"/>
        </source>
    </evidence>
    <sequence length="1261" mass="141608" checksum="062E658DB21D60A8" modified="2023-02-22" version="1">MYRPPDVLLGSTVYSTPLDMWGVGCIFAEMCIGCALFPGASDALDQLDRIFAVRGTPSAQHWPEALQLPKWDQFQLDVYAELEWADVDIKLVFKLNDQGRDLLTQLLKLPPRERISAAGAMLHKYFDELPKTLHALSPTESVLIAFNGNKKLSALAADDDRRTCYILLNALKQERQRQMAFNPAGSQENPDGSRKISAKFVLNMRMAYPSGGEGLCSPEIEISEGGTMLDGKGKFNDLKAMLDSNRENVKMDAMRRIINMVARGKDVSEMFPAVVKNVAAKNLELKKLVYVYLVRALKDPNQLIRASALRVLSSIRVQMISPVVMLAIREAIRDMSPYVRKVAAHAIPKLFALDHELQPQLIECIDNLLETCPDRLDLLHRHFRLFCRALADVDEWGQVVMIGLLTRYARTQFTSPFTSYAIGNRKAGTISKKRETDSSADEEDNDGDEEEHSKPLDCDHNLLIASVRPLLQSRNPAVVMAVAQLFFHVAPHAQLAAVPRALVRLLRGPNEVQYVVLVNIATICATRQTEELFAISKSLFEPFLKSFFVRNSDTIHVKRLKLYVLTSLVSEANVQLVVRELQAYLQMLDIAEAAIDTIGRCALAVPSAAETCLGCLIRLITTSGQDHIICASVVVLKRLLHADAPMALLRRMFQLINTVKAPMARSCILWLIGTHINKVPKLAPDLLRIVAKTFCEEADSVKLQSLNLAMRIWAIDPANREGKCAILVKYVFQLARYDRSYDIRDRCRFLRNFLFLNKDANSIVFPLDMFLHERPAPVVHNSFADRAEHFQLGTLSHLLNQKCTGYTELPDFPSQQPDPTVRRSAYPLPSDDFEAVQGKETTVTNAEAIDEEEEEAEEYSSEEGNEEEEEDGDEDEEEADEQSEEEVEDEDESDDGQGVEEEPIPSNSKPREEEETIAEEQTAEAQPLVVKTTTKKDGQQKAVHSEDLLLLDIDFGPPSTHINFVVSKWRRATAQYVPDRFELQLVESLSSGGLCIAGRFCRSPCLYSTSMVTVQLQLSYQSRHIRCCDVRLSPATNCFLPTSGPILVEALKEGERRTLTLGIDFGDSTQTSEWTVKWGEGGEKTTKFDVQAPYEEQVEGIECDAEQFVECRAKLTGMNQIRCALSRKTDQFIGRALLKVCNCKQVLGLKLCFAAQTVSRKELVLISLVGRGKEDRFDDDTDDCSVQVNCDNITFASDVTVRLPAKTFIHSLTFCDSNLYNIPFCFVCFSSTKHRQIDQLADTLIGIVLPFLLLQVWFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAU7</accession>
    <name>A0A914HAU7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integrin alpha third immunoglobulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15813.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15813.t1"/>
        <property type="gene ID" value="Gr19_v10_g15813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0401">Integrin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="6">
        <location>
            <begin position="566"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15813.t1"/>
        </source>
    </evidence>
    <sequence length="618" mass="69572" checksum="4B0F95DBEF5DCFBD" modified="2023-02-22" version="1">MSRINLLLELLITRDSTPISTVQQTSKAKEFSEICKQLILVEDEENIKRIQTKREDARNQFHSTHFVGNNRVYFYVHWDLLFSVIKPTARAHSRRRGTFTSRSRATQFISTRSRATQFITSRSGASQFTTTAAYGSAATKEPKASDSGWPLHSNTTIIRWEATDVRDSVVETLLSSANPIVDEICEQTLCLMLYLNEHHPRLLERVVQMCYTKNDLVGIRCFRAILMLFSQREFPCEYISLLCLCQSFASSIELASVRQTAFLHVQLLRHQFLNNTFSPTSLTPIKEISSNSANVQSEIMPKDGAADEAEKSAKDGANCQNSDKNVVTDTPIAAFTSKKEVLTALVQLFSSDQQKSLWEHEEVTQLCWKPDSVKKLECLVHLLVAYLHSSISDLQQPAFGGAFLPNGERTWSESNSVFASNSFSTYRSGRRQHLAQNMANASHPTNASQFQSPSILSGHSRSVSYTQQISTQKFISPPQKVAQKKSSDMRHSLLIGTELLSPTQSDARPLIRSQSATTLKLSEDNANVLLTEKESETISQLLFIGVSMMESNLDNEYFLGLSFVDKCKDGSALCVPLHCHFDYIGRNDSVLIEIRARLWNFTFSANYRAILTNKFYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAZ8</accession>
    <name>A0A914HAZ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14924.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14924.t1"/>
        <property type="gene ID" value="Gr19_v10_g14924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14924.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24253" checksum="66BD0C6281FEC51D" modified="2023-02-22" version="1">MCNLSDSFFNRNFETTKSALAMKVGESVVCRMGGDTSITSTNGSFSLLNVLVTLLGIANGAGTSAGKQKDASGKQPMQVDGAVQEKLNVNECAICLEEIETGEIQLRTLPCAHVFHQCCIQPWLIEHNTCPKCRNQISNEEDTPEEYLNRNLGNRQNINMEINDGNSVQLITYGDLNIHVLERSNGRIAINGHPISNEAWTSQMRDASEMKAWQMRDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB85</accession>
    <name>A0A914HB85_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ribonuclease P/MRP protein subunit POP5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HB85"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15503.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15503.t1"/>
        <property type="gene ID" value="Gr19_v10_g15503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48414">
        <property type="entry name" value="POP5 HOMOLOG, RIBONUCLEASE P_MRP SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48414:SF1">
        <property type="entry name" value="POP5 HOMOLOG, RIBONUCLEASE P_MRP SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15503.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16239" checksum="75F70D45B5126923" modified="2023-02-22" version="1">MVKLKRRYLLAEVLADGQVDSARLYSALLEQIAHLHGDFGVGAVCGSLQVKVHDRATKTVVLRISANECHFITSALPFVLSVDRTRCVLHLLLEASSMRTIEKALIKRNVSSLYAQLKAAKTKGDRQFIQEAIRSVTGFRVAHIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBF9</accession>
    <name>A0A914HBF9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBF9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15055.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15055.t1"/>
        <property type="gene ID" value="Gr19_v10_g15055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="398"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15055.t1"/>
        </source>
    </evidence>
    <sequence length="689" mass="79017" checksum="6ABB8BEA3BFE31FE" modified="2023-02-22" version="1">MDYPRINERELKFPIPSGIIVSGPSSSGKTQLVLRLISCADEMFEPPPKAIVWAYGEYSAQIPELERQGIIVHAGAPSDEMMNKLPKPFLIVYDDLMGEIDAKKLADLYTKKSHHNNFAVMFLTQNLFDKAMRVPRSNAQYIFLMRAPNDMLSIRNLATQIFPREQGFLIDAYKQACAELYGRRDICSRAEKMANKLILLPIEHYRGLVAAREKIDDDVTEQTNFGFVKQQFEKAKRKRAANVSEKSAEYNQQLRRYLKLRKEVKDKPVKVQLSNGMRLMTKPPATGVQLKPGPEEVEETIVIGGSEADDDEPAAISSPKFSTPKEVEAAPEPRVSRKRDLKKQEIMAKKEKLLSIIKSNPTRFGVNERDKIINPSTGREFVDFDLTWAIERLVNPRPENAPSPSDVQADLADFQALSRKNSGNRYLLLAVDVLSRRMFGVPAKSKKPAEMKRAFEELFGQMPKLPETLYTDRGLEFVAKPLKEFYAEKGIKKFETSSKKKAAVAERAIRTLKTRLYKYFSAKNTSTWVDVLAKFLAAINNSVCRATGLKPNDIGEQNAREVWKKVYGEAIEPSSKGPKIKLGENVRIPEPKHIFEKGYMPNYSDHVYTVDERRSSNPEHYFLKDYYGTKLKRKFYLPELTKVKVDKNTLYRVEKKYKERMRDGQKEMLVKFIGFPEKYWVTSEDFLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCG3</accession>
    <name>A0A914HCG3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCG3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15830.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15830.t1"/>
        <property type="gene ID" value="Gr19_v10_g15830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15830.t1"/>
        </source>
    </evidence>
    <sequence length="812" mass="91884" checksum="7B661059054E76C7" modified="2023-02-22" version="1">MEEDNAGDIVKWLYRDSTRLDCSSGQVKVTNEHLHTKLWQAKLRGNLLAFKPLDFASEPFLIVCEKIKVQRSDEHKNSLTMRQSNKEMLLSFQTEKECDHWMLKLMTCSHRIVQAEYEQVLYKRFTQPLPASTTGRISNNFGYFLTSPYTREQLFSLSQSHNFPTRQIKCQEIMYECKLSMLVPQEMLRHSSKWATELRDELLDKLWGVKNAAIVETLHTAIRHLNSNIEVFTQASEFLASYAGPSFRWASSDHFKCSNKSEKTKRKFRVSFLFVPTNLHVQTFHVDGRLAASFLTVGAIAALPLRFSSGGLSKIRNKFSAALGSIALDHTNENRFHSRRQILLAMKRKIGELSRNIDVKWRITSDGRTDEIDTEIFSEIQQMHEQINDMINSFPNIFNLVDSLCEGGLAQLQHKGSESVPRDTLRNQLDRLQAQFDSLSSKMIAVGRMATTDDNLSHDQRECEQSVRGAVHSTLDALHGLTASLLSGQALALVQSLRKPSDCQTFFHLQLRSDALLSMVVTLVTTSLLTALYGPTTDIGTFWAHSPPLVTMFSFLSCYGDENGMLEDAFEMWHQFSAVVSFRFVKMSSSISQNCVPQIDGFRTALNVSIPIHPREMERLPKRMANEEWFRPKVTFWNVGINHEASLAASIGDISLEEEVNRNALQQTVEHCLLLNSAEQQIENAGLIEQLLAELQQTVSSCPSKKNWSIFTQVMALNSAVGGMPVISCKSGKDRTSMGITLDEGRILRECCGVSNQQMAEMVECLRRNGVRRENCRKNVGKPFYSFSPFQLGFLPPPFRPPSGTFSNIVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCM8</accession>
    <name>A0A914HCM8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCM8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16284.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16284.t1"/>
        <property type="gene ID" value="Gr19_v10_g16284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16284.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14416" checksum="77F79029235991E7" modified="2023-02-22" version="1">MQIFSILIPLLKGFRHQNAAGQKNKPKEYNDNTEQLEMAKENNNTTEQLEKAKEYNNNNEQLEKAKEKNNTTEQLEKAKEKNTTTEQLEKAKKYNNNNEQLEKRSSVLTHELYEFNLVVVVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCU9</accession>
    <name>A0A914HCU9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HCU9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15942.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15942.t1"/>
        <property type="gene ID" value="Gr19_v10_g15942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF91">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="554"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15942.t1"/>
        </source>
    </evidence>
    <sequence length="900" mass="102210" checksum="C0B0D10A64AAEFFD" modified="2023-02-22" version="1">MTTKTLDKLKALSYLSYEKLKSAGKMDRDSLRTLKRMDIPKRFKYFVEVEREARMRVQEGDEEEAYILYSRALEIYRLINDSSDDKFKRSKEGRLYFETAMRITTDFEQVASSLQDRFKLLHPDDLLPTITSSNSHTDELTPAEWSRNHADTVFKTYVKPIELVRYVEKGMNALVLDYRENQGESIEYKNKHGSMKVVHIDQRDVVFGSLLHSIVKALDISIRPILENISHFDVVVLLGDVNDITKKKGSKTVILVEALTTYNFNHKLKRPPVIIEGGYENWKHAYPVYVTETYDIPRFEKSFDEQFTTWIVEARKANELRIYYPSLSTSVGVSGLSSEVQQKPLEPSRHRGRESHIEPSDVLYPSAAPTKPAIASSFIDTNISTLSDLPIHNDKKTVDKYKQISNKTTKIPTIDRSNKPSVAKSLTDQPLQKLTFNDKECRDAHLNKENFAPTDASRSTSPFPQVLGGAGSDPNIPNRRRLPDGTSSAPSHQQPTRPSIPERINRNDPALRQQQQPQQEESTENYFQTSYYLSKTKISQQSASERRKTMSGHTGLVNMGNTCFMNATLQAFFHTPGFSDLFRNGNVASFVNSNGNFGTKGIISGCFSALLDLVWSGDYSAIRPQFFLEVFARRVNEQLADRRQHDAQEFQIFLLDALHEDTNRVDMRRPFEQNYDSSNLLASAQDFFTRSGQFSSSPVNDFFNLTTISELQCKTCNATSVRFEAVTQISVELPSTDNCLKLKDCLKAHFSTTTLDAPWNCPRCKSKQPATRSTKIWKMPAVLIIHLKRFSLSARCFVKNEVEISFDINGLDLSPYIHQKSPLRSAKYNIYAVTNHSGHLNSGHYTSSTINLASAGRDWLHFDDEHCTACSAPSSTSKQAFLLYYKLASPHGHDPNKAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDF1</accession>
    <name>A0A914HDF1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDF1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16480.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16480.t1"/>
        <property type="gene ID" value="Gr19_v10_g16480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037641363" evidence="2">
        <location>
            <begin position="24"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16480.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28762" checksum="4AD284884435F15E" modified="2023-02-22" version="1">MTSACTLLFQIWTLILTFHRLNGDGHIDLTIEQLTLRTAPPGESKIQIIPLRCRTTTASVRTFAVDASSGVVHQRRFDFTSAITPNVVVQLDIMSDSHQLLVATGFFSPLPTHNSPISPVFSFVNYGNIFMYRLKAMCSVGFVGPKCTETCEPPKPGAFSSLRRLYAKAKDSTAQNSGRKWPKYAHIHSSELSTKSSCPRAHNLLPSAPSNFCWSISGIRSIDKECRNPNVNEQNCSVSTPTSWTLQRQKKPEIGPSTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDG7</accession>
    <name>A0A914HDG7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDG7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16344.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16344.t1"/>
        <property type="gene ID" value="Gr19_v10_g16344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037823797" evidence="9">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16344.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24892" checksum="564115F1F119BB0B" modified="2023-02-22" version="1">MFSHLVLLLFAFLETSQALYFHIAETEKKCFIEEIPDETMVMGRYKVQLYDPNTKAYGDYPTIGMHVEAKDPEEKVILSKLYTSEGMFTFTSHSPGEHLICLYSNSSAWFSGAQLRVHLDIQVGEHAQDYEQVAAKDKLNELQLRVRQLLDQVEQITKEQNYQRYREERFRQTSESTNSRVLWWSIGQTIVLLLTGGWQMRHLKGFFEAKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE67</accession>
    <name>A0A914HE67_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE67"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15797.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15797.t1"/>
        <property type="gene ID" value="Gr19_v10_g15797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15797.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22271" checksum="9C6FDB66F63694E7" modified="2023-02-22" version="1">MRRDEEGPSPMLGGGGGRNITIFIAWMAMRSLEEVSALYLRLKGITGKQSTFGTLEEFSSIRDVGGVQQHSRRWRSSAFETLEEFSIRDVGGVQQHSRRWRSSAFGTLKEFSIRDVEGVQHSGRWRSSAFETLEEFSIRDVGGVQQHSRRWRSSAFETLEEFSIRDVGGVQQHSRPFGTLEEFSIRDVEGVQHSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEV0</accession>
    <name>A0A914HEV0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16347.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16347.t1"/>
        <property type="gene ID" value="Gr19_v10_g16347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036689440" evidence="4">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16347.t1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44295" checksum="F2DB64D852C4F9D5" modified="2023-02-22" version="1">MLSAIRFGPSPASLLVVFLFRFPRPSLSLICYSCTTTLSANIDENAQVALRLFLNSVYELPPVHRFCNMEQDVETITTVQCSTPNDQCVKVRAENDGLEFVIRGCKSRVYKPDVGIPQNVHCRTGSPSLCFCKENLWLSREADIERQSGVTSSMHFLVHLAPFLLHFLVRPLTTVSAATTNEDLVEFLFQHQQMCGNPFSDAQWVPVLDLCEIKCDEEREICVENDEMKQRCIKLPEACVRSWVSNKSANLRSSSVVVVTRPPSQKQTPSTGRRASQLATTGQQQQQRHNGREGGGMERRNVGGRRWAPAQTSPKTTTTAMPARSTRMRTEETLTAAPAQPQVEGKAKRGPEEKRRDRWTLIPVKRKEEGKKPTGIGRRGPFILQSVIDLLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEW0</accession>
    <name>A0A914HEW0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEW0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15976.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15976.t2"/>
        <property type="gene ID" value="Gr19_v10_g15976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15976.t2"/>
        </source>
    </evidence>
    <sequence length="85" mass="9318" checksum="F22635FA1BA41465" modified="2023-02-22" version="1">MNSAKKAIPRPNGNRTESPSQKTAPTTARPMLQFAIPPGLAIPRQQQQLLQAMAGRAREGSIFHRPKSDRSIDSVRPSLSLLTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG02</accession>
    <name>A0A914HG02_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HG02"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16822.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16822.t1"/>
        <property type="gene ID" value="Gr19_v10_g16822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="117"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="310"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16822.t1"/>
        </source>
    </evidence>
    <sequence length="619" mass="69801" checksum="95E5BE05C160A660" modified="2023-02-22" version="1">MHRIAVHVRLASNPSRALSLSAGLQREWDLNDPEQMRLYKLYRPERVTPCVRGVDLLKDPGLNKGMAFTLEERQYLGVHGLLPPAFMTSEQQAYRVITKLRKQPDDLARYIQLDGLQDRNEKLFYRVLCDNLKELMPIVYTPTVGLACQKFGLIYRNPKGIYVTINDNSISKICQILSNWKSPEVKAIVVTDGERILGLGDLGCYGIGIPVGKMALYVALAGIQPRWCLPVQIDVGTDNQTLLNDPFYIGLRRNRVRGEQYDRLINNFMKACRKKYGQDVLIQFEDFGNKNAFRLLEQYQDKYCMFNDDIQGTASVVVAGLLACTRVTQRRMSDTKYVFFGAGGAALGVAEMCVRQMESEGLSYEGACDQIYMMDVGGLITKQRKNIENRHVPFAKDLPDTHNLLEVVQSVRPGALIGASTVRGAFTDDVIRTMAEFNARPIIFALSNPTSKAECLAEDAYRVTHGTVLFASGSPFKNVELHGRVYKPGQGNNAYIFPGIALGVILFKVSTIDNKLFLMAARMVAESVTEKSLAEGRVFPRLKEIREISIKIAMKIAEESYRDGTAKLYPEPTDKEMFIRSQIYSVEYGELINRTYNWPTLDMKHGFPVPVVRRDSMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH35</accession>
    <name>A0A914HH35_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HH35"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17444.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17444.t1"/>
        <property type="gene ID" value="Gr19_v10_g17444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000064">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000246">
        <property type="entry name" value="EGF-like repeat and discoidin I-like domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037917107" evidence="7">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="179"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17444.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="52152" checksum="980A8090B8BDCD4D" modified="2023-02-22" version="1">MSCSFILPLSVVLWQSSLSQSLSVSSSASSASSSSCFCVNGGKCSSDGTQCLCPPGFDGVRCEKCVTNSRCRGFCQVPGGCACPEGKGGQFCEKDLEFCARHSPCQNGATCLNNPEGFYTCECPSGFGGRNCERRLTGCAERPCRNGARCVPQLMLNSVTGFRCECPPGFFGQFCQARVTQGCADLPCQNGGSCADSPSPFSSSPIPSRHRRVPPFFCLCASGWAGQICDQPWENCRVNSCQNGASCVIDPNSSIGFVCRCPHGWRGILCGEREDECGLMKPCQNGGICVDGSSAFRCVCRKGFGGELCQEKLEEFEADRMLKDKGTPRGLARSSDSPCSPSSSVQSVPVSSLSVPIFLLLFLLFAFLFSLITSRRLFRPPPPSSASFSSSSSAVPPISTIPRLKTTTESPSTRTSSKHVDIESARYVCEPTFRIGPQSRQHLEESVMSAMGSRKPTRSDDRPCRGGSRESGLYEEIGGEMCCQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH42</accession>
    <name>A0A914HH42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vomeronasal type-1 receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HH42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17308.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17308.t1"/>
        <property type="gene ID" value="Gr19_v10_g17308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17308.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45339" checksum="F9B49C3EAC57E25A" modified="2023-02-22" version="1">MARHLAASLKFRRFQQIHSSTKHHNTQQKAGGLGEMDILDPQLLLVLPNSSSSAYICSSRILQLSLWFISSLDVLLAVLAVSLNSLLTASIFFARPLSVSMRRSFSVVSISYAFLAGILLAKKCFWLSSALSAGSPCVPLVSSALCKLQEFPVVAVYLHSLASPLAFAVQMYAKGLNDKWTCWDYYRGRKILYGLSHQTATTDGRRMKGTSSGNVFVSPPLSHRRRSSSTQPPTFLLFWLCSTQQMALETSRRKVLVNCSLPLAVRQKKLLFALLTLMLSSQLVQTLLWQSVSVSSSQQQQHGHQRGCQSHRPPSLLRYLTLSFRDLFLIEAILWSLSAFFTGLVLFQQFVLTKPCGRCTRLMVELAFTTLPLHSDFAQFSKRHCPSKNRPLLRSRDPSRQCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHA3</accession>
    <name>A0A914HHA3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HHA3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16939.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16939.t1"/>
        <property type="gene ID" value="Gr19_v10_g16939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="10">
        <location>
            <begin position="546"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="11">
        <location>
            <begin position="740"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16939.t1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="123170" checksum="B9BEF89B4FD055EB" modified="2023-02-22" version="1">MAADITVWMCRFEQLVQQQQLEAVRHELETMWLFFRSSYDIFWDVQQPFAEYETEQKLACAINNFILKIEEFVASHKNVPSDEKKTLADWHKLKDSTFDDLKLDEIDENNKIGDENCVEPVELVQKLHFEEFRKFSLSKIEENATKWAQIVDVLSTKNESKRNILQFLKFGDVKILFKMLGIVLNTENFVDCANIECANSTNLVESLEDKPNLNCDSEEDEKIIEKDENIEKICLSSIKLRNDLPQIEMLEENEKEISKEKDPKIVEKNKNEKRKNSLAKEWTRIGPLNLKAFCEDAFLYGKYAEFVSAPSDGLLVLLDIGAYANEIGQRIQMVEELHKIDNKLVPNLCHVEIKPIKDEWTQLLEAEYDNVDAVPALEWKLHQILWKILNFHQNSEAVVENADNEMRNVKAQIHLRKFAMALLADQTKFGNLWTKIEQKKRQKLLQNISGMRCGHIRFDHLKLRWQKMDAQIQIDQLLFNKLPESEQKSNKNLCPIFPKLSQQLNFVENIKNETKMSENLDNYLEEIVYKNAAEFDEKIKKSLPKIKAIFDEWSEGHDVQLLITGSFLLGTHTIHSDVDLLCIVPGKVIKKVQFFGTDPTQCQQQERVCSDGTNSSLYCQLCQNELVTGLLKSTNGPVLMIKFMFDQIPYDVTFVTIPDRKTLPPKMDDQTLEDLIAKFKKPSEINTKMLRVLSSYRSTLFIDNLILDGQNNGNWQQILRTDASLAQQKKDKTFNKNAKNFRTLILMLKLWAKNNYIYSTKYGYLSGTILTIMVTKIVLLYPNASVPFLSEKFFLIYSTRPLFLPIQLNELNESTGTVNPFFVRNPVEQEMPVYTPTFPEQNAASSITHCGATVIRKAMVSALTQIKSADAAKLFEWNQLFNKSIDFVEKYTYFVLINCVGEEQFGLDKFCQFVDGRIRRQIVYDLDPKYGPNIGTHLFPNIYRHKNCAISNKFLIFPFRLNFCTVWLLGINSRVNKAQMAPLLAQFDGTIKRDYLKYNPTQNNESAGGGGKSKRHKEFKMPQIEDIEATFGQSKLALKSILVNKWEMIDTLESDEEKLFKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHM7</accession>
    <name>A0A914HHM7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHM7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17448.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17448.t1"/>
        <property type="gene ID" value="Gr19_v10_g17448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037631802" evidence="3">
        <location>
            <begin position="23"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17448.t1"/>
        </source>
    </evidence>
    <sequence length="672" mass="75788" checksum="332372ED1C42B9A3" modified="2023-02-22" version="1">MHRPSMVPLPFLLTLLASFANAQQHGRFDGNRSAGTAAFPSPLFEGRTASAGNGGPPPPRRPPSFSPFTPFLSPQSLPRPLSAGRMPRRRLDVEDGRRTSAANNSLEGGGGIGRAENGERWRGGRGMMNEQRQRVVDATSPSGGMGLSRMATPTNLSSPAAGSDPTVPFPLPPKGPFDGGARKEGRPELLVEKEDKTDLERVKKDGDDDGQGRKRGGEQFPPDDGMLKKLAEEERFRTPPQSVPPLAGRFAPTRTTPNGAMGMKAADDRTSGEFKNDEHGQKGKEKIRRNGGEEAQEEEEEQLVATEGDGMERMEKRKKEVERRGMGGVGMGKEEAEGQRSHCCSVRCKGHSLTVREEGVQQSDGTEEEEKKWKKEEMGKKEWETEGEKGGEMHEKDAEERQRSEDGRRLRLLQNRKIDDGLWVAPLIMFLLLLLLLLLLLLLLHIIRTGPRLRRPLRQKKGLLENLRMSANPRTMRNDGPPASPRALHVHPLPLSLLASSAAFPTLTNSFPTKSDPPIRHFQSHLKNSMESKGTEEEEEKEAEDEKEEETKGKEEEEEEEVEAEEKEEKTKGKEEEEEEEEEKETKGKEAEEKEEEKVEEEAEEEEKEEKEAEEKEEEEAEEKEEAEEKEEEEEVEEKEEKEEEEEVEEKEEKEEEEEVEEEEEEEVEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHV8</accession>
    <name>A0A914HHV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17081.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17081.t2"/>
        <property type="gene ID" value="Gr19_v10_g17081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17081.t2"/>
        </source>
    </evidence>
    <sequence length="711" mass="82005" checksum="E028169FC0F3F300" modified="2023-02-22" version="1">MSFDNCEKIALRENEDKNGHQHLMKCKDFSHCRQNVNNKLTKHSEALFPGIAVVEARQRLAELRMGGTSNGTMPPQHPKQTPNGAGTKLVMIDQHPTDMKMLNSALIHCPLSSFESQQSQKEMAMFIQQKRQTKTTSACSKETTNVPSGKRMSAGVAWHKDNAVKRSFPADWHSQHNGQSLRTTANYFIAICAISALFLHQLPVHPTQTKSRIQLTPKHGTQLNSQIDTAASNGTSPEDLSIFCNTYVEARDKQTCIIDEECIGQFQCSFQNCAKRLKNNVTFMYHIWAHIAQQKPTKDDRRINLQILLAEHTGGNCAGDDIFTAKDQRSDVSRLHTCPECLLEQPTLYRARLHYHRVHKRGKRPLLETKRNKLIVCNICEQVFDTTSMQQHAVSHCLPNTRQQLDLPYECRFTGSGKKCLFRVSNRSALLQHFCNEHDDTHVLLCPFCLLTFSVPSADRRKRLIRMREYILHMTLHHEEKSRHCAHCVVRFGFSQLSQMEQHQEQHSKGGDRKWLQWRHKRFDLNSIQLDKSCAFTCSDMPDALVKFSNDDSQQKKKWNRMMEAKGTADVGCGKGAEEMQEDSQHVVAGDDEMHEAKLFGLLCMADVPRREVNEEEEEQKLHRADSADEGEKQKGERGREELRKWLSEFMMLREATELSQRVLQPNQTRLLERLMNQDEHRERIQLVCEEELREMRINASLMFYSLDDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HI75</accession>
    <name>A0A914HI75_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HI75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17394.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17394.t1"/>
        <property type="gene ID" value="Gr19_v10_g17394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17394.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31591" checksum="8373DD1C22680A38" modified="2023-02-22" version="1">MSDESTLNGTFCCQLLQLHFLSPSPSIFRSMIEAAAQSFLAARQRYREKKKLSQRLSRSSSGKSLDRNSLAGVEEELDDTECEQLSTVFAAMPDKYHLFERMFLRLFLEVDPQIALTFGMANIAEIELRRKTPFRYIPTLYHYGHGSFAETGKRGGGADHQVKQLSFTAARWLSFKSALTWTFSRGEQKDKLHVQWSLLISFLICEIKDAYLAHIRTLRSNSLPHIVETYRLEFHRRKKSQTQLGPLHALPPPAAPSDKRNGQQNEGKASGGGATALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIF3</accession>
    <name>A0A914HIF3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIF3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17820.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17820.t1"/>
        <property type="gene ID" value="Gr19_v10_g17820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17820.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27210" checksum="9EE84B676585E6BD" modified="2023-02-22" version="1">MSRPKPFLHFKSSISGSIRALKSSSSPGRPSSLSYRFAATAPRKPGTSPHARQSQRGKSQQQQQQQQPVQQEESRPATAAAAEEEEKGTMVKMAASASRMAFAADARHTKAMSSRPAGDPTTEHLSRVASRARSTTAAASVRRTQSAKSKRSVSRGSSSGGHSVKKEDGGTTTKLVEFGPLRFMAKESTKVKLVRQDSQRPGLRAMLYGLTLKMEREEKLQKKLLRKRAPLYGAKISGLESPNNGTLSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ13</accession>
    <name>A0A914HJ13_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HJ13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17618.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17618.t1"/>
        <property type="gene ID" value="Gr19_v10_g17618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17618.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31469" checksum="2D6A7B3FF70166A9" modified="2023-02-22" version="1">MEELSRKHAYEVSKDTLEGDKVRAEIVHVLDAENITFLMERKIWPEKFIVDAELLTKQSENSAEESSSLETTKNRQKGESMGNSTTSLMLQEEEVVEIAKDTGFSRNQIVRLYSRFLSLDRQGRGYLDRDDFQRIPELAINPLGGRIVDAFFSGFGESGAKSELINFRQFVKVLAHFRPLSKSKPNVVNSREEKLKFAFSMYDLNKNGYITRDEFKVILNMMVGSNITADQLDSIADRTITEADADKDGKISFDEFCKAMERTDVDQKMSIRFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK26</accession>
    <name>A0A914HK26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1845.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1845.t1"/>
        <property type="gene ID" value="Gr19_v10_g1845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1845.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32796" checksum="01BBFF41A4501DA1" modified="2023-02-22" version="1">MHLSPVDIGNVAKFNIGEQLERRRRSVQLVVGPPWGDDLKLPPAPRRQSLVERCQTSLRKSKVAFSPGNFSTPFLPPIVPKSASATSALSPPFSANTLRFRRQSAFSRASPLPPLFLSVLNDAKNDEGEEEEEEKPISGSSAISSNQREPLRRPLIIETFQPNCQPAEVFNEDADVEQSPLTFDTAQELLLVEQKSPQLVRKLDVVRCRRMANKMINELLERLQQKNLPKQTGGDEKNTQKQNKQKKELAMAELQRDFFPYVYAKAERLVVHRMANSFLDGTLENSAASKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK73</accession>
    <name>A0A914HK73_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A914HK73"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2083.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2083.t1"/>
        <property type="gene ID" value="Gr19_v10_g2083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF141">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038154433" description="Carbonic anhydrase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2083.t1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36716" checksum="DF30A72B01AA2B34" modified="2023-02-22" version="1">MMEKIALSLILFFISVHRNSCSDAWGYDDHNGPHKWGKQCQYGTRQSPIDIRTSNLEFAVINELHFVNYEISGAVELKNNGHAVVVSGFEKWEGNRQRPYIYGGGLSGKYTLAQFHFHWTADHDDGSEHTINALHYPMELHLVHVKDGFTMQEAVEQSDGLAVVGVFYHIGDDGTSMAKLESGLKSVVEKDSATVISNYTVGVHLPSIRENFYRYAGSLTTPGCNEAVVWTVLAEPLPILMQQLDLFRAVQGPKPGHPLSDNVRPVQPLNGRRVQFRASALNRHRICNISTPEHPSRCRAARAVLHASLQLTATCAFIFFSSVLAIRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKV2</accession>
    <name>A0A914HKV2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKV2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17557.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17557.t1"/>
        <property type="gene ID" value="Gr19_v10_g17557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17557.t1"/>
        </source>
    </evidence>
    <sequence length="395" mass="43119" checksum="5AB97D37C7965C4B" modified="2023-02-22" version="1">MPPTSFKAQFPATTSSPRGIPFSASAPPVFYHIAPFGPALAAALLFLCVLRMLLRKCQNRLSLFWQRRQPVIRQLCTRHDNHSAALSSSPVHGDSPVSDSNRHEIAPWERPIGSDLSPGSPLFFLHHPDLFFSPPFAYANSPFHSQFFFFPPKYEDALKLPLPARSPLTERRAPTLRIPSLVGRSRLNPSEQSPPPSYEQVRAVVGQQQQQQPSIRLFCQRREYPPTYFSSVGDLPSLSGGSTQGQNDSATGGITTGILSDRPCSSLSLVDDPRALAQRRLRIFVAKSARKVANERREKGGTTAGRRTSGSGGRRAIDGAGRTAEAGGRATNETEDEAEEMPAPAFLSFCEGMRTLSLSHRLSPGAELNVLQFAAAIERKQNKIGILALALALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKX5</accession>
    <name>A0A914HKX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2087.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2087.t1"/>
        <property type="gene ID" value="Gr19_v10_g2087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2087.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38244" checksum="5F13E8D9A3748737" modified="2023-02-22" version="1">MAMSTRKIVHSAKCPLGKLSTRRIVHSAKCPLGEMSTRRIVHSANCPLGEMSTRRNVHSAKCPLGEMSTRRNVHSAKCIDKRQYNEFYGSREVPREEIGGRNLPYPKTDDSYERSQNRYASNNHYTYPEDYSMYDQSHDDAFNYGNYDPNQDFDQGYSMAENADHRDSVENIVNLNNEIGKMPTFLRLTTKQNQQSFMALEQENSRSRSIIERQKRGWAVRNGQNIEKAYDKFARDVRSGKERFMQSRKQILIGLSRQAQDLDRKIQLIISDQNISRRQCLIKVNALLAGSTDQTRTEMREKLHVIGPLDGNFPPIQKANKNDQTLGNLQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL51</accession>
    <name>A0A914HL51_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HL51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17631.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17631.t1"/>
        <property type="gene ID" value="Gr19_v10_g17631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17631.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21220" checksum="AE1DACF7DD6DDEA3" modified="2023-02-22" version="1">MPQPIRRKIPPELLAELADALSFDVRWGAVRVSAAFDYFVVKKQFKWIKNELARQEILRKERTRLSQAIGRINWVAGRIRQLRLIPIRNLLAAFFRVPNNVGLSELEDPSQLTAEMFTRQFAVMTERIDRENIETVRYNARVLQSVYDIGYGYTGEPGAPFCTSPSSDVWGVGRRASSDPLHPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM92</accession>
    <name>A0A914HM92_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM92"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2790.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2790.t1"/>
        <property type="gene ID" value="Gr19_v10_g2790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218135" evidence="2">
        <location>
            <begin position="34"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2790.t1"/>
        </source>
    </evidence>
    <sequence length="387" mass="44410" checksum="3940FE1D426EBB0C" modified="2023-02-22" version="1">MQMTKTSRCDKYKRHGFVCFLLVSLFCFVVVDSEVLQLDKDSIENALKGRDLVLASEKLKENPKVLFAMVDSEALPELAQKFHVNKYPTIKLFRFGELIKKEYRGQRSVDAISEHVHRQLESPVQTFNSTDDLTGRMDGSKRNVFAYFIASDDSQPAIQHFHRSASSLRDDCSFWIGSGDWVRSVVGNESGIFFRDPHAEDDFHYSGPLDNFDYMKKWLTDKCVPLVREITFENAEELTEEGIPFLILFRIPGDLQAERLFTDVVSTELEDQKNTINFLVADGKKFAHPLHHLGKSERDLPLIAIDSFRHMYLFPDTKQLGEKGRLRQFVLDLHAGKLHREFHQGPDPTQPPSDNPSKLANTQPPSSVFKQLKPSETRYSLLDKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNM4</accession>
    <name>A0A914HNM4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Casein kinase II subunit beta</fullName>
            <shortName evidence="5">CK II beta</shortName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HNM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2809.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2809.t1"/>
        <property type="gene ID" value="Gr19_v10_g2809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2809.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24372" checksum="606B602603EDCCEA" modified="2023-02-22" version="1">MSRSSRFSWISWFCDLRCNDFFCEVDVEYIQDRFNLTGLSEQVPHFRQALDMILDLEPDDDYEEGQSDLVEQSAEMLYGLIHARYVLTNRGIQQMMEKWNNEEFGTCPRVHCENQPVLPIGLSDVVGECMVRVYCPRCCDVYLPRSKHRHTDGAYFGTGFPHMFFFVHPKQKPKRPNTQYVPRMYGFQISPVAYQPDEDVQGTLEENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP41</accession>
    <name>A0A914HP41_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP41"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3341.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3341.t1"/>
        <property type="gene ID" value="Gr19_v10_g3341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="96"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3341.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25884" checksum="82E6F4890661BCAA" modified="2023-02-22" version="1">MTIYRWKRKLGQTKPNKHSHSEQKELMKRYYEIKDKNPEIRDEDIAKMLKIGGSTLYKWKKQFKRQQFHPNSVDGHSVEENAAANVQKIGNSNSGSCTKFVQAADVSWNAPFKAKIRQQYEDWMLHGEKTTTSSGNTRAAPMNIYLNWIHEAWEGIPKENISKSFKTCGITNAFDGSEDGEIHCFKEDGPVPNGMLRLQQAREMAEFDFLAEGKFIKLFLKNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP51</accession>
    <name>A0A914HP51_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2603.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2603.t2"/>
        <property type="gene ID" value="Gr19_v10_g2603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2603.t2"/>
        </source>
    </evidence>
    <sequence length="773" mass="82644" checksum="B070532510BE1255" modified="2023-02-22" version="1">MLPDHPGVGKSAVVFFGDVKSGRGCRDASGRDASGLDASGREGREWPGRTRVAGKDASGREGREWPGRTRVAGKDASGREGREWPGRTRVAGSRVAGTRVAGTRVAGTRVAGTRVAGMRVAGTQVAATRVAGMRVGGMRVAWMRVAGTRVAGTRVAGMRVGGMRVAWMRVAWMRVAWMRVAGMRVGGMRVAWMRVAWMRVAWTRVAGMRVGGMRVAWMRVAGTRVAGTRVAGMRVGGMRVAWMRVAGTRVAGMRVGGMRVAWMRVAWMRVAWTRVAGMRVGGMRVAWMRVAGTRVAGTRVAGTRVAGTRGPGREWPGREWPGRKWPGREWPGRKWPGREWPGREWPGREWPGREWPGREGLDASGRDASGRDASGLDARGRDASVRDASGRDASGRDASGRDASVRDASGLDASGRDARGRDASGRDASGRDASGLDASGRDASGRDASGRDASGRDASGLDASGRDASGRDARGRDASGLDASGRDARGRDAMAGTRVAGTRVAGTQVAWTRVAGTRMAGTRVAGTQVAATRVAGMRVGGMRVAWMRVAGTRVAGTRVAGTRVAGTRVAGTRVAWTRVAGTRVAGTQVAWTRVAGTRVAGTRVAGTRVAGTRVAGTRVAGTRVAGTRVSGMRVAGMRVAGMRVAGMRVAWMRVAWMRVAWMRVAWMRVAGTRVAGTRVSGMRVAGMRVAWMRVAWMRVAGMRVAWMRVAGTRVAGTRVAGTRVAGTRGPGREWPGREWPGRKWPGREWPGRKWPGREWPGREWPGREWPGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPA6</accession>
    <name>A0A914HPA6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPA6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2971.t3">
        <property type="protein sequence ID" value="Gr19_v10_g2971.t3"/>
        <property type="gene ID" value="Gr19_v10_g2971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="124"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2971.t3"/>
        </source>
    </evidence>
    <sequence length="322" mass="36074" checksum="F20ECFF791D95045" modified="2023-02-22" version="1">MSKTNSTNRGHITADPERCATFSNLDSSGEVRLFLGQHRNRLEINGGKNDAILNSGSWWPCAMVVAELEEQKETNKLLRKQIDELGNSSKKELEKGMNQLKEEIIAKMEQYQKEKQQKNIGELQKTIAVLNDTINGKSLLPQQNRWEFAACHEDLALIEPNRLVVQFTGKNYGFSSVRAERPIPKGNFGFFYYEVKILGNGGGMYIGLATKQMPLDVRVGVHEGTYAYDYEGKFWAHTHAIGGKPKFVKGDVIGCGVNLATRQIIYTKNGERLDTANCLPILSLICFRALRCSILSTQLNPTLDRTLNSILSMAFEIGKVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPU6</accession>
    <name>A0A914HPU6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPU6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3535.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3535.t1"/>
        <property type="gene ID" value="Gr19_v10_g3535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3535.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8478" checksum="0FDC7208CE1CA24C" modified="2023-02-22" version="1">MNREVPAPDALDPCGRVGVLCWVCATNAQLLKSAPHLKTKDFQPLTRQSSPKVKGDPWATNECGKNLAMTSSFWIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQM2</accession>
    <name>A0A914HQM2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQM2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2805.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2805.t1"/>
        <property type="gene ID" value="Gr19_v10_g2805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2805.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7259" checksum="FCC5335873EF0EAB" modified="2023-02-22" version="1">MERTLLSSRSLAKYFSSGVRGGEGKRPTQLLESFEPSIDGLGTDKQNEIKEGNKQKQQQTASSIASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQN8</accession>
    <name>A0A914HQN8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Unspecific monooxygenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQN8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3009.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3009.t1"/>
        <property type="gene ID" value="Gr19_v10_g3009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3009.t1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57903" checksum="B13C9099765ACB59" modified="2023-02-22" version="1">MALIFFFVLFSCVFLFYQLYYKRQKLPPGPFPLPFLGNLLQLHRYGNAEDVFLQWRRQFGPMYTFWMGQIPVVCVAEYAKIVDTFVRDGETYAGRYTMPFEHVFRGEDIHGVISSSGERWREQRRFALHVLKDFGLGKNLMQERIMLELGAMFGKIDAKSGSIDEVNVPELIDVAVGSIINNLMFGYRFEGGKEREFWDLKQSMDELRNFGSPITMIWLCYPRLLGRVPPFSAVAGQIKRRMDNVFGFFESRITEHQRELDKCGDWEAPPKDFVEAFLKEMKRKNEHIKMDTFSICSNALICALTCGSPDKKPTAKVLAWGVAQLLNNENCLNKLYAELDTVIGTDRLVSVADRPNLPYTNAVINETLRVANILPNNVLHALTREVTVDGFKLPKGTAIVPQVSAVLIDDAVFSEPKRFKPERFLEQNGTMSLARCDELIPFSIGKRQCLGESMARMELFLFIANIFNQYKVSPGQTVPSLQRNKDAVVHCSPFTCRMEKRKVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS57</accession>
    <name>A0A914HS57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS57"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3456.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3456.t1"/>
        <property type="gene ID" value="Gr19_v10_g3456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3456.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14429" checksum="6D62A14164245956" modified="2023-02-22" version="1">MCDKSFKLTIGFDCLTRLRSEARWHRFFDFYSPRLFEFSSMQQEQVVSSATVKCPNGSDDSGTPNLQPQTLQAKNRFILQIGYMAFYRGVDWKDWVCPTSNDTMEMIMQSVGNSAINDCRSTQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSQ1</accession>
    <name>A0A914HSQ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4290.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4290.t1"/>
        <property type="gene ID" value="Gr19_v10_g4290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000050">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000245">
        <property type="entry name" value="Integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052452">
        <property type="entry name" value="Ankyrin-MYND_dom_contain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025927">
        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13891">
        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1134"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1168"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1499"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1532"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1565"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1660"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4290.t1"/>
        </source>
    </evidence>
    <sequence length="1916" mass="216742" checksum="BCE009768B6A46C2" modified="2023-02-22" version="1">MAASHHQNYVDEYRPDTTVSTSTDGKILMEATSSTSNFQRNSVNDMNCIDSSDHFLDQHMEVDYQQPSSSSNLGNSPIKPQILEGSTVVTERITIPVLSTTKKSNAHFCEFVDQIKGQCKQRAINTFKYCIRHILFDPTAPYKQCQHQRKPKNKHDKPVLCTNAIRAACMEIYCSTHLIMNGLKDPKVSTKKDKANLKGLDKDKSAEHSEKQKINGTDGGCTKPPAVQSVQRDTSNIPKNSDFDGVGGGYPPMTPPDRVDLQHLPLNSQTISSNLIRTKNNDALFYNQQMDKSRMNLIPNLPPDVKPPYLESVNFRPPEVNQQFLCTTQDDFQFIRNREENLTVKRVQNEDFPAYNLSKTHPQLAAKLLQSRPLGQQTSEVPPPGVQANEKVLVDNSRNILNQPPSNVSMDVCFPTDSSAMPSPNNIYHHHQYTSSTAFVSPPNHERFPKAFTNEQQNNFLHSKYEANGIQLREESIGGDSVLHRVPQQPPLPRAVVANHKEFVQSPCTYVPSSLAFLNSNPPPRRYDLNRLERRINQNACNEHFDLLEFQRERDFSFNESIQENGGGVLLNKKRQQKVIKLRQKRQKVLIDGAFRAIPMVDTMCRIVESQDFDRTDLFPLGLEPSDDESSDDSFPSLGEEKFGCVPRTSSSGSSRLELYLLKKQLRLESSRLVQRAKLCVPINTTAREYKNSVGAALRVRRNNSKRENIREQQKRLLRCSFTSQQQTQLSESAHVDSVPFRCTNVSLPWSRHCAEHVTYNVAQQMFSFCKWRLCNESVPITDLVLFDGLCRRHYYTQQRQQLTAAAAEQPQRQQHNNNILAPNCELRPSSAITYQDQSLKKNGHYFQQYRAQCGDSLSSAAIRCEPFDGHHVHFGPSSVPVNRDDHLNETMDVSLASVAKDLGFDGHDLTDMLAKLPVEEGFEGDMDPDEDNLLTDINKEDSDEAPPGTTLGHSWADVEQFLLEQEEGLHQPPKNNSLTHNTNKPNSTFVTNDNTMMASVEDSNEQLVKQIIGPDTVKGDNCSMGSLKEEQNTAAIIQQISDEMEAIPHASASVLEKMARFHFKMADHPGTETPYFIFEDPMLNQKDNFTSKELKILTDEERELFQLIQEDKIEEAKTIVRDGKVRVNSLDKNGMSVLDLACFKGNEAFVEFLIEHGASPDNRAHQDGYTALMFAALSGNGRLCQLLLDAGANSLAQNTIGKTAAELAAFVGQHECVGIITNYISFRDVDLILHPKGAESDVIYPPELVQFIQLLTRTHAFHPVKLTFDVSENGLVWQHVKKTVFTLDTLFEKQLRSKQPNEVLSLKLWIVLYTFRELTKFVDERLKKAAGDNNEQKFALQFGRALLQDEPNDRVRNNEERFVRQAIASFPYKQSTLWQTLSLHLSNVPFGEPPPAFVLLCQTLLGSRFVQTAHFCRTCSIPSAKKRCKNCKTLYCSAMCQRFDWTVHKQCSPTYKVHKPNVPIIMEDIFGWVREGNAFQVRVWLDDSEHDLNVGDDHAFSLLHWASKEGHVSIVEMLLSRGARVNATNMGDDTALHLAAAHGHRQIVVKLLLRKAEVNIQNEHGMTPLHYACFWGYEQICEDLIRSGALTTICNKRGLTPLDVCQPQVRQSVYEIALSNGQNPQQKIQYSGETWQNSKTFRSRDATWSRYTGVDLQSLALTKSIAQSHSGTLYRGKWQSNDIVARVLNVPNVTSRISRDFATEFLQLRIFASAFVNPVLAVVNQPPQLIVISQFMPFGSLYNVLHEQSSVVIDHNQAIRFALDIARGMSFLHSLDQPVLRYYLSSKHVVIDEDLSAKMSMADTKFSFQEVGRLYSPAWLAPEALQRSPETLNTRAADMWSFGILLWELNTREVPFSDLSPMEIGMKIALEGLRVTIPPGISRNMFRLINICLNEDPGRRPNFDQVIPILEKMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTQ7</accession>
    <name>A0A914HTQ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTQ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3880.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3880.t1"/>
        <property type="gene ID" value="Gr19_v10_g3880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="6">
        <location>
            <begin position="198"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3880.t1"/>
        </source>
    </evidence>
    <sequence length="558" mass="64016" checksum="C0ED358636AA97E8" modified="2023-02-22" version="1">MENHVVKTRQNNKKLEHEGCLYIFHKLNADGDVKFWRCEHQHGDVKCRGRVHTSLNDVVLKTVGEHSCQHSAANVAKQKIVTGIKRRAAETMETPAAIRAHALQQIPTPVMSNLPTKNATKKLVKRVRHEIDAPPPVPASIEQLIIPEDYRIYKRSATAQEPFLLADSGIYRREGQERILIFGRQSFRDWASEMKTIYCDGTFAITPSPFTQVYVILARRDKWVFPICHCLLTAKTQATYERMFDLLQQCWPMFKPHAAAIDFEQAMVGALKAKHPQCDVNFCLFHLVRNMKKRIAEQGLTHLYNTDAAFSQAARMITSLAFLPVADLNPALAALEDFLPENLNGVLDWFVINYIGRLRQNNTRARPLFQPDQWSVHQRTLDGTDRTNNYAESYHRTLQHAFGHTHPKIWSFIDKLREQQKMVDVNMEHFIAGNAPPPKAKKFRDADRRILSVLHRYINAKAALPQVQDDHQYIQNQINPHLIIEVLKLLDVIGMVARLFVNGLFVNGFFVNDFSSMDFSSTDSSSTTFLQWTLRQRLFVIGLFVNGLFVNGLFVNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUH6</accession>
    <name>A0A914HUH6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaoptin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g4787.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4787.t2"/>
        <property type="gene ID" value="Gr19_v10_g4787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF387">
        <property type="entry name" value="LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN SMA-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4787.t2"/>
        </source>
    </evidence>
    <sequence length="1378" mass="155824" checksum="90CC2E59267890F4" modified="2023-02-22" version="1">MSPPPAKPKLNVLHDGSLASSPLNICKIGKASDPDGWAQCQCNFLNGEAASAEPQTMRRRMLVRGMPETVGGEEAEAAGIVRVNCEGMFWTSLANLSGIWGGDEGALWSSTKGGGATTDIGQELSHPSVGALSIKKTFVKAIGQDTFRSEPNIHFLDLSANAIESVNANAFRGLEGQLFHLDLSGNRFGQVPRWSLTYLRQLQHFSLRDNRIESLHGDTFAELHLRNLRYLHLDGNKIDLVATGSLASLPLQVLTLSNNRIAQLPNGSLPKQLWLLDLKNNFLSEVPFAALDGLNSLRIIDLERNNITELGTHSMGWLKAELDLRLALNRISRLPEGAFDGFRRFERLDLSHNQINSISEKAFQAVESVSELDLGSNALLQIPQNAFLRFANSLRRLNLEQNKLGELPKALQPLISLQQLNLNGNRIRTLDANALARFRANLSELSLAKNMLGRIPSEGIQGMVSLRSLDLSDNAIESVGKMAFGSFDGLSPSGVSSLQRLSLAGNRIRELTNPGAFIYLSNLIRLDLSHNRIARLTKDVFERLDSLEWLSLDYNKMLEFPRNTLSPLNRLKHLSMEANLLQMLPNYAFQWLVHLQWLSLAKNRLSSINAKMFHSTSAIQIRWLNLANNRISRMETAAFQNLPNLERLYLSHNRLTTLHTQILSSLKNLRQLSLAHNNINTTQESAFANLPHLEELTLAHNRLRTIKEGVFHKVPSLARLDLSHNRIEAFDLDFLGASQVYQLRALDLSFNVIRKLEIQSAKYSLRSLDLHNNQLEFVHGQMFQGFEQLRSVDLSQNDLIDLNAGSFWSSTRLERIVLSENNLRTIWRDTFRDQNLIIELNLAGNVLHSLDSGVFGKDNLLGLDLSRNNFSAIPIRALTSVRGSLSVLKMSRNGVKVLNRKEFEGMKNLNVLELAENRIETLEEEMFSFLPKLKHLDLSGNPVNTWSPHVFLGLSPFTEHLDLSRTGLFSLPKLHKLSSLRYLNLSGNFLYELPPTDTDPLPALQMLDLAKNRLVELRAQLFDKISEVRMLNLSDNIELRSIDGALLKGLGQLEILSLVRMSALSRLTGLSDFAYLLRLRSLEIFSNPSLSSENISQILQLLPPLRSLHFESTDEVFSGRELAKADLRLLRELSITGANIKHIGHNAFGRLRGYRLHLSIYNTQIRHFPPEALNHMNAVTFLRLFLRNNRINTFDPFLPGGQRTVLNERGTVLEAVDLGANPLKCDCRMEWLTEWIAQQKMNVQAEKQWTETKELLRKAECGEKDAFEEEHRRDRNAKENLLDTYEGAQFIWYRTKNGQPFRQFPSAEQNHYDYGLNDRFDGFHQQQQQRRMGCDEDGRRLNNSAEGTWRTANLLWLLALALIRATETMAQRVPAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUM6</accession>
    <name>A0A914HUM6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="4">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3922.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3922.t2"/>
        <property type="gene ID" value="Gr19_v10_g3922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="46"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3922.t2"/>
        </source>
    </evidence>
    <sequence length="1448" mass="162661" checksum="A248A8FC9D0B02EC" modified="2023-02-22" version="1">MSESSDNSVEEDSPMHVEKALREVNANLKLDDAPTTANNVNKIINFNTVHMNFATTRNANCKIRFNETCWNKPDEWLNDGFITVYLAYLASISKRKVVVVDSLVSTPATAVVRRSSFKNYTFGYDPNNAAEVILMPLNFPNHWTLLVHDVAVGTFFADSLHTSRMDSARSELIKDIIVDIVPIERSSIVIEKVNNLTPQQDGFSCGYFACLSDTVPYHPRADVVLPCPFVKRLEMVDLQSTSKFVQSNVQMDSDDSDDIIIVDVPANEKNVEESISFIDPPLHEQAVHPASTAMNAVLTQAELPGENQADELALIVESCQAQEPIAQAGEVIFKRPKTPPRRSSRIKRLSNTLSRSPSPAAKRAPTTKGLGLATPLTKRCHMVHKSWHCAAAAAKHFPDYSDSGKLGEKKCPHCGAHLFQHEDSNICCRQGRVELPTLSPHPDGLKQLIVGDNQTREGKEFVRNMSRYNNLLQFASVSAGNKPCPAGGPMAVILNGEFHRRISSMQAGATQTPGFGQLYILDPVEAMEQRRNNPTFTGEKITKEEEFVQGHKLNEKTLESLEKMIQENHPAAKAYKQAREQMQDLFNTQKAQELRFFRMTLLNERRAPAAVKDPKLHPNQIITPSTGEGMFAIHADPSGAPPPKGIWVENKQGQLNEIAPFSPWTDSLAYPLIKPCGDDGYYTGIKYAKPPSRKRKSDVSTDNLFDTDVDSDLESCAADSDASSDAGSVASGTSSVSGRFGKARQFVSLRDYCKYYLAIRDNDVAAGYHHILTCGGGLGQRWVLDQAAKIDWQIATFLRRPDMDLRISTPRNLLQYLINQYNKQKARQNPNAQRKSVDDIGSVVRLSEKNVNSLQYWKKMYEDCNTIFARYHDAKKARLFITFTNNREWPEFKQNLYKNGQVFTDRFDLWMRVWCSKIAVFRHELYEKNYFGTIIGSGESMEFQGRGGPHAHIVAQTDLNAIPEVIQEYIWAHIPSLPDKDDDTPIAQMHREIRELIHMQLHRCMHHNVLFAYGNKANIKYALKYPFKGPGHCYVECKEESGNKIGIDEPAQYAKMNFRGATEAYAVVNSIAFVRLSHQVVNREAQLIIIDEITMLNNTVIEVIDRVCKEMATRQHKELLFGGKTVIFSGDFKQSLPVVPHEGLAAQVAACFQTSPLFGQFTTMKLTINHRLGKGQQDYAKMCRQIGHGEAGEFFWIPPQFLLHSSEDLINFVYPDFQQLLGNDQELLNRLILAPHIQTCDEINELMMDNVPGQVREYLSTDKPLDERPLDIDEIESEVAALNQRADSGMPPHRLRIKVGCVVVLLINKSDREGLINGTRIVIEELGENKITGRAINGTAVGGQVRFFIERTRNVYEDKAPGGLKYERLQFPIKPAFAMTILKGQGQTIRTVGIDLEREVFSHGQLYTAFSRASDGNNVRVYAPNRETDAQGRAKVLNIVATNMLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXS8</accession>
    <name>A0A914HXS8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXS8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4761.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4761.t1"/>
        <property type="gene ID" value="Gr19_v10_g4761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4761.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9198" checksum="22050A4784637014" modified="2023-02-22" version="1">MDGGRSFFLHWKCAVPMRKCGVMPNRIKSSANLFSLDTVSAEVRLAKALDRETQQRHVLKMRECWPYWAFGRSPAILRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYF1</accession>
    <name>A0A914HYF1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYF1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5811.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5811.t1"/>
        <property type="gene ID" value="Gr19_v10_g5811"/>
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    </dbReference>
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        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
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            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
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            <begin position="255"/>
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            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5811.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38040" checksum="8B8B3F0AC63D9776" modified="2023-02-22" version="1">MDGNIPQFMFDVKRRLNLLYYETIASIARRWNHIFTVFRGISYDESEHQQQSSDSCPKQHKCSTFVDLKRVVLGKDDIEPDIRMRSQLYPLPEKRQTTSSLSTQQQTKSEFTICSRPLQPKVRQPCREISNDSDSDSAISASMSTFKTDNEEKLIELLTKNNQMLQQLLTKQRDNAPNPPIPSPAKKAPNPPIPPPPPPPPSFSLKLSTHYVESINNESDKENSSVKRISPNPKGQQKFTNVFEQIKNGDFKLKKVASSPVSSPSSKKKKKLTEGDMIMAALKSGIEKRRKVLKSDSDLDESKLDDLDVCWSDEEEGEKRKGDANAANGGEVFADAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0H1</accession>
    <name>A0A914I0H1_GLORO</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0H1"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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            <begin position="25"/>
            <end position="198"/>
        </location>
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        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5732.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21072" checksum="A8C2D122395E8EED" modified="2023-02-22" version="1">MPSPSSLLFSTIPIVCLLFNSCFAAPHPCCPGSQHLVALMTKYIGTFSTGRDESTVCANAESVVNAIKSELNSMPECQSPNGGGSGIMGEIDAQLTTSEHMKMVITNDDGCAYNLGFARAMFDMAKSAAGHAGNGTEWDKLTKDFGKQIDAIDTLSTELTIFVPKVLFKNPRSANFAHKKVPSPSDVRTNPGEYSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0H5</accession>
    <name>A0A914I0H5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0H5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6174.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6174.t1"/>
        <property type="gene ID" value="Gr19_v10_g6174"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH09530P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39956:SF1">
        <property type="entry name" value="GH09530P-RELATED"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="246"/>
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        </location>
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        <location>
            <begin position="352"/>
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            <begin position="586"/>
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            <begin position="204"/>
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    </feature>
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        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
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            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6174.t1"/>
        </source>
    </evidence>
    <sequence length="662" mass="69983" checksum="53DCE35826EAE83A" modified="2023-02-22" version="1">MRCASPLEERVGRERVGRERVGGSELSGSELFRNELAENELDENELAENELAGNELAGSELSRNELAENELAENELAGNELAGSELSRNELAENELDENELAGNELAGNELAGNELAGNELAGNELPGNELAVNGWAGNELAGNELAGSELSRNELAENELAENELAENELAGSELSGSELSRNELAVNELAGNELAGSELSRNELAENELDENELAENELAENELDENELAENELAENELAGNELAGNELPGNELAGNGWAGNGNELAENELDENELAENELAENELARNENKLAENKLARNKLAENKLAGNYLARNELAGNENELAENELDENELAENELAENELAGNELAGNELPGNELAGNGWAGNGNELAENELDENELAENELAENELAGNELAGSELSRNELAENELAGNELAGSELSRNELAENELDENELAGNELAGNELPGNELAVNGWAGNELAGNELAGSELAGSELSRNELAENELAENELAGSELSGSELSRNELAVNELAGNELAGSELSRNELAENELAENELAGNELAGSELSRNELAENELDENELAGNELAGNELAGNELAGNELAGSELSGSELSRNELAENELDENELAENELAGNELAVNELAGNELAENELAGNELAGNELAGNELAGNELAGNELAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0L1</accession>
    <name>A0A914I0L1_GLORO</name>
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        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A914I0L1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5503.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5503.t1"/>
        <property type="gene ID" value="Gr19_v10_g5503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF141">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5503.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33469" checksum="7F2A4FD4C3585627" modified="2023-02-22" version="1">MVNATLNEFRLFLKQRKIMSHLFVLFVPILMLAQDQFMTQAHEGEHWGYEPENGPSTWGGLCQTGKRQSPINIQKDCFNGNKTPKITFENYDKNGSVTMTNSGHSVMISGFNNWTLQPFISDGGLGSKYMLNQFHFHWSQNTNGSEHTVDGEHFDAELHMVHIKEGLSFSEASNSSDGLAVLGIFYKIGHNGHSMLALQNGLKEVTKKDASAQIENYVPAVNLPDHLEMFFRYNGSLTTPECNEAVVWTVFAKRLSISSNQIKLLRQIQGPNGKVLNSNVRPRCHYQKDGEFVLLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1S5</accession>
    <name>A0A914I1S5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vesicle transport protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1S5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6514.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6514.t1"/>
        <property type="gene ID" value="Gr19_v10_g6514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6514.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18288" checksum="5AF5D92BFF0F91E2" modified="2023-02-22" version="1">MNNEIGAINKYKYGTNNNKSGTTCCCGCVSIETGTYVAAIVSWVIYMISAIFFFFGPKHFLFGMFNIGFACPCLLVIFAQQARNPLLFVPYLIAGVVDVIIRWFICFAFFNMCSLSNSNGCMIIVVFIVVTILFHSWFYSIIVRGFLAAREVESRRYRPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I200</accession>
    <name>A0A914I200_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I200"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11056.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11056.t1"/>
        <property type="gene ID" value="Gr19_v10_g11056"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6761.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6761.t1"/>
        <property type="gene ID" value="Gr19_v10_g6761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324188" evidence="2">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11056.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6761.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8311" checksum="B6569B7B2B4FEA4C" modified="2023-02-22" version="1">MRLHVVVLILLAMLAVPAICQSDNVKKKWMALMEVAKDSHQQDRAYESFTKSLHDAPQQPRQQQSQPPPKDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I241</accession>
    <name>A0A914I241_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Segment polarity protein dishevelled</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I241"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5904.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5904.t2"/>
        <property type="gene ID" value="Gr19_v10_g5904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048730">
        <property type="term" value="P:epidermis morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000400">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF24">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG MIG-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="12">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="264"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="11">
        <location>
            <begin position="511"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="603"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5904.t2"/>
        </source>
    </evidence>
    <sequence length="833" mass="90937" checksum="4907018EAE621FCD" modified="2023-02-22" version="1">MNAGGEELLAGCGSNSTKVYYHLDDSATPYMSEVLVPSNLITLGDFKAVFTRKGYRYFCRRWDAELKSEVKAELVRDQQRLERSATTGLFELFLLSPALPSSSSTAAGNAGTLPRMRKYGGASVAEMPLLRPLNHHLSALALSSIVASSSNELMTVDCAGGQRVSMVTGTTASSGANTLISKRAGEHLAEPYSSTSEDPYNRTSISNSGIFLRSKPAMSFGNSTGRPLLGRQKWRRQRHQKPYVPSTISSASDESSYSLPRIEEVKLRLQEAPLGISVACQDSSIFIYNIQPGSAAEKSGHLEVGDEIIQVEETRFEDLSEKQALYLLKQLKFVKKTVTMYVAKRRPLNVGGGSSSDKSDALSQFCETIQLDIGQWVESTKQFLDVPAGAKIYNNEQIIDAPHPLVSEQIQLTAAEKETSDEEQAAYLDRRAGVGPRLVPAVQKKQQNPKRADEQANNNADVVFATTGSGGGHPSSCPAVTLAAAAVAPSVPSPLHAAMEPRVILRRMAHPRSGLDIRDRKWLKIPVPMSFIGDDMLDWLMCNVQGFKDRKCAKAFASTVLLTGHIKHVLNISVFNEKCYYIFDDSFVAERLRILRRAAQQQQQQQQQQMDAKNEHKLASSTGAADNGNKMQRQLQPESTTEITYMSSPSSPFFGAVPPTHASQSANMGGPPQLVIVNNPKYAQCPAVLNQQRNCAVPVLNGNTAIPLRQMNMNTVLPAWPVSPIPFARPNQTPRLPRGPPAAAEVRDCESPETTNEYASMVQGEINCGAQFDVKFDGFLVPNNNNNNTIGGVIKNSPNYVNNNNNSILLLPPPPALLPAVSPVPQRQIVKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3F1</accession>
    <name>A0A914I3F1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3F1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7147.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7147.t1"/>
        <property type="gene ID" value="Gr19_v10_g7147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
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        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF21">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="MgtE"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
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            <begin position="85"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
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            <begin position="423"/>
            <end position="445"/>
        </location>
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            <begin position="126"/>
            <end position="259"/>
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            <begin position="300"/>
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        </location>
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            <begin position="47"/>
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            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7147.t1"/>
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    </evidence>
    <sequence length="492" mass="53443" checksum="0113E3E009113C84" modified="2023-02-22" version="1">MFSKFIPNDEMDEGKIGTKQIFTKSSDKPIMFITRMDRVDVGDVAPAPKIGGITDNSKHENGTALSRDNDGNKKPPGDEESQTSFFAQTCAPFVLAGCGMVAAGVLLDQASSWPFLSEVPEALILVPALLGLKGNLEMTLASRLSTMANLGQLDQPQQQITTLYSNIALVQTQAIVVALIASLLAVSAHWIEGNQLDIARSVCVILSGIVSASITSMLLTSLMVFLVITARKYGLNPDNIATPLAAATGDVASLAFLIIFGTWFYRLREQYLMALIILLFLLISSVPAWTWVAVQHQWRPVINGVGGNLVAVQASKLSTYLHQFGKQGILPANTLITYVNPLRTFACKETESNNAVILLLMSVPGHLLFIGLLLLTGEMGVQSLNLPFLAIYLCATTFQVATLLFCCQLLCRCLWRLCWDPNINAIPLLTALGDFLGTSLLALAFRVHAELFPEYTPVQEDVLLLQAVEQQIDTTLATGSELLLLNRTLAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I403</accession>
    <name>A0A914I403_GLORO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
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        <lineage>
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            <taxon>Tylenchina</taxon>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I403"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="32"/>
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        </location>
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        <location>
            <begin position="32"/>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6609.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14133" checksum="64706A1D877BC59F" modified="2023-02-22" version="1">MCNKRFGHMKSSKWDVTGELCHSNRGHRQHLQGVQHQAQQRGEAHQNVPRTSQVVSNPGKHSAYTNQNMTIDCGKDVFINNVVFHELLNDAVIPPRPLLEAIEKPNAVGDLSEDSDIDIQELDLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4D2</accession>
    <name>A0A914I4D2_GLORO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="Gr19_v10_g6699"/>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="1"/>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6699.t1"/>
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    <sequence length="117" mass="12894" checksum="586EA6A8FB1E41F0" modified="2023-02-22" version="1">MSSSPVPTGKSSSGAPSEHTPPTIINEGSLSLAEFVQRLETPGHQTVKSLTYWRKGRGLEMLVTPPQGGDRFAGRGNDFVENLAYERAGRERLSVHGILEFIVGFLNGRAYMIEYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4I6</accession>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <lineage>
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    </reference>
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6538.t1"/>
        </source>
    </evidence>
    <sequence length="450" mass="47882" checksum="BEFCF04B9A09C3F8" modified="2023-02-22" version="1">MSAKNSSRNSSSSSAAAVVVPSGGVHNSATAAINPSCSSSSSPQASAAMIVHVPPVPVPVSGRPLQIPRTVPRGDNSSPSGMLTSGQICSRLPTTAATFIHRPIMPLLLMSMVVFLLQAVHAAPPNAGGRTLHVPYGAVLTLDVGNDRAHSPTGFPGWARLNDSSDKMYGIPQANDVGEYTIPLKERTVRIDVGSELKQRCEEGSPTTWLEIVDPRRLADLSMENQFNSVKTLLDTLNVQLQDVRLFAFDYLDKYRTVTKTDHKLEQRALGEQLVFTVNISCGVLTDQAIDVINAAAENGLVFQVVQGFLTITDDNGRRQLEATSSPNQLAADDDQTTTTNATNSQSPSGDASSTFSIVPLIILTGKVGQGKAAVRHQWQSARRRGPFIIACRRFDHADGRHELLHHAVGNINAAQQAAWHFPNATLHASSAGAVATAAVTVPNTTPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5S7</accession>
    <name>A0A914I5S7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyltransferase 3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5S7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7580.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7580.t1"/>
        <property type="gene ID" value="Gr19_v10_g7580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF70">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037805385" evidence="3">
        <location>
            <begin position="18"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="415"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="499"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="639"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="4">
        <location>
            <begin position="264"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7580.t1"/>
        </source>
    </evidence>
    <sequence length="786" mass="90327" checksum="CB4266BDA5A66105" modified="2023-02-22" version="1">MGFYFAFFLAFLPCILATNLTHYPESRVWSFIRSMPRRSVGERCAKSLDLVETYLQDQRTLMAQREFFSEAFSTGDASQFISRDQDRWLYNAFMCIKAAGEQTYSASEYPLHYCYGETKPGNESRGPQQQQIAYGMCIPSTCSGEMDRMELLKEWQHNVHIDSVKSNGSRELLDADDRRLLFGDCTKSRHTRQWWEQPVPLLQFAFDMVLVGLISVATVLHWRRGGRSKSLRVQLLLSFSAARNMKKMVQMPKDLQSTITCMFGLRFLSMVWTLIGHSFIFVQAFLSNVDEFKDDLVDNFWNQWITNFTLSVDVFLVLSGTLTAYSWFRRAQQPHSVEARVGWTAWPYWLRFYRHRLVRLWPAYIYTLFAVTTRVSVTHYHPMWPPTDPAVQCPKHWLENVLFINSLTDNRCLPWTWYIGTEFIFYLLSPVFLLALRQSPVYGLSLVGAVSAASALANLITMLQYNFPPTQMLWKQPPIFSPDFIKHHLVIYIKPWYRIGPYLVGLVLGFVLAVQSVSPQRKRSEDARSFRFVWAGWAMACGAGFWSVFGLYPALQGWDWPLYHLFYGSCARTIFAIALSWLIYACHTGIGGPINWVLSLSPFLPLSVLSYSVYLFHMIPVVFTYMISPFPIHYNSKFYVLIHCVVQLAISYGFGMICTLLAELPALNIERILLSPKRELPRGEHCVEEDKKNGYGSAVDGYDSGAMRMAVPSVTVEKDVEEAGGYSTSCADEEEDEEEERDEGTEKQKRHNCTHTKAGGCARRGFLRLNPPPPAFFQIVMFSSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6H4</accession>
    <name>A0A914I6H4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6H4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7069.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7069.t1"/>
        <property type="gene ID" value="Gr19_v10_g7069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7069.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31123" checksum="20A1048BBFB90703" modified="2023-02-22" version="1">MLKRQTATVSSISRIGKHFLCRTFATTQGQDAELDKAAQLRTRAVCVEKNETLGGTSLNVSSIPSKTMLNTLHFDLEEYYVIESEPGVEVPMVAEREPYLREDLIKRPLNELTVDELVHVLRDQRARNIVVIQLNAMDSPNPLFGVVCSPFNSRHGKALETVLRAFLKHNFIVNHFVDVPKRKRPARWNILDMAGIAVHILDEEMRQIYALESLFLGLDEDGITEEGTFNSSPWLNEYRVPEEMLIKAPSQRAEASWPKVLRDERDVPKAHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6M1</accession>
    <name>A0A914I6M1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6M1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7109.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7109.t1"/>
        <property type="gene ID" value="Gr19_v10_g7109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="119"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7109.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42653" checksum="165382B036AB9CBF" modified="2023-02-22" version="1">METQLADQHSKAVEDELEKCREEIMKMHGELKPNWLENGDAEFQKLEAEKNALVTKQAVFGRQQMLNSQTLQKMQVLQTKIVDLENRKLMNDHQTLKKKVMKLEEEQKKMLLRMATSEEANVLMKALLVGELGIGLVPKNCWDPTACHPDLILIESERLIVQHTGTGWGWRSVLAEKSIPSKKIGVFYYEVTILLVKENPVFIGLAPKKMVFDAAVGWFVGTYAYGSRGLILGHEVEGCHQVEGGNEVEGCHQVEGGNEVEGCHQVEGGNEVEGCHQVEGGHEVEGCHEVGGHEVEGCSYDENGRPFINAEYFGVKGDVVGCGINLATRQMFYTKNGRRLDSKLLVTSAEELFPCITLSDFDSKIQANFGPDDFKFKIAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6W7</accession>
    <name>A0A914I6W7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KOW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6W7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7467.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7467.t1"/>
        <property type="gene ID" value="Gr19_v10_g7467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7467.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35908" checksum="55255926A6AD7D81" modified="2023-02-22" version="1">MLAFYNFKNLQPRPHYKRRILASPITLNTFRFWFPTNDICDHQLLARDKHMAQDGGEQKDVGEKEEKPKPDGEAKDGLEKEEKQKRKKSKKKSRRREKSRREKKAKAGEAAATEQPKPESAEAPVTEEPKTEAEEGGAVVDQPKAEAGDAAMEQPKNCSTSIVHFWIRTQKMKLNPFVSSSARKSRKRHFNAPSHIRRRIMSCPLSKDLRNKHGVRSVPIRIDDEVTVTRGHFKGNGGRIMRVYRKKYVVHVDKITREKANGTTVHVGIHPSNVQVTKLKMDKDRRSLLERKAAGRARVTGILKGKHTEETIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7F2</accession>
    <name>A0A914I7F2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat domain-containing protein 83</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitogen-activated protein kinase organizer 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7F2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7446.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7446.t1"/>
        <property type="gene ID" value="Gr19_v10_g7446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="11">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7446.t1"/>
        </source>
    </evidence>
    <sequence length="807" mass="89991" checksum="3B00E9118D9410E1" modified="2023-02-22" version="1">MTTRLKCVFRVENDGRTMGRPANGFVAFGCERKGLAEDEVKIFYLLLTTRLNKGHPRKIKLDHFDCLLDKMKRQGMATIQFVEPKLNVYISQADPKKLCQFLLHLKGLLRPGSVVPAPSATAAQSVPVPSSSSIVPSVSNVQRQCTAELASSKPTRLCIESRQQYQSLIKQGSANLRRLDITGIGFRSVDMRWFGMRQLQQLSLAGNKLGADEWCTERNWRQFTAISMLEQLNTLDLSQNEFKHLPEMFIDALPLSIVNLNLGFNRLVQLPNRISRLQRLNVLCLDENPLEELPEDLSLIDSLRELSLVGLKQLQFLPSSLCCAKYCPPRFNVLDLSGNENAPFITGDRRSRVEEEEEMKSHSEPELAAVSAVMPPTLCELAAAAVLNNRKLIHAGSHLLRSEVADCLPTLVYRQMRQWLRRCAHCCRLFAVSSSSGATRKEQFARADLRRCATVLYGPSSAFFRSQLFLLNDVYFIIISVFRSQKYINAWMASSSTSIDLPTKLVQCFDCRQGAIRAVRFNVDGNYCMTAGSDKSVKLWNPYRRVHLKTYSGLGQEVLDVVGSSDNSLILAGGRDKQPTVFDVESGKMVKRWQSHGGAVNAVAFNEDSSVAISAGQDGLVCCHDVRSRGPPIQVLDEARDSVLSLDVNASEIVTGSADGNVRLYDLREGRLFIDFMKDSVISVHLTADNQCFLAACMGGVIRLLEKTNGQLLADYSGHRNVDYRVDAGILASNNEVVSGSEDGRVYIWDIVESKLLTRLEHPDGAKFVHSLATHPSKQCLLSVAREKLYLWQCPAALETDADMEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I839</accession>
    <name>A0A914I839_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inositol-1(or 4)-monophosphatase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Myo-inositol monophosphatase A3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914I839"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7791.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7791.t1"/>
        <property type="gene ID" value="Gr19_v10_g7791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052834">
        <property type="term" value="F:inositol monophosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000012">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF4">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7791.t1"/>
        </source>
    </evidence>
    <sequence length="439" mass="49568" checksum="F63BA06C7BC26AF4" modified="2023-02-22" version="1">MTFIRINLRNTLFFLIASSFIYLAFLIWTAKDRIPEFEVQLRDVLSYVVLAAEMGGHAIVRTFAENRKLRVVEKSQMDVGRPELLTKADLISNHLMLSLLRRFPLLKVISEEKSEFLSEKDVEQYRADNYELWLGLREALSKFPSWRIPLARITVWIDPLDATQEFTEGLTQYVTVMACVAIDGKPIFGAIHSPFLNETVFGMVDHGLFDSNGLPISVPSDREDKLQKTILISRSHAGTVSDLIKRAFVNDSTSYVIEPAGGAGYKTLRLIRQSADLYIHTMAIKKWDLCAGDALIRSAGGVLLALDNGLPIDYSAKTAAATKTSDQIEVHKNGFLMTLRSPFSFYQRFKKVCLFFSDGYLLAEFRLNLARARLASKAEALLVRLVRQSPTFCLPKKSWSPLFGLKHRKSPKILPTLPSSPSNMLHQNARERGMTFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9H4</accession>
    <name>A0A914I9H4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I9H4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8740.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8740.t1"/>
        <property type="gene ID" value="Gr19_v10_g8740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8740.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17144" checksum="38C45468E8A38E31" modified="2023-02-22" version="1">MNSCPSVPLPYKGRNKLNRSELAKKSCRVKGIALKERCPFNGSAGQSLSFVRPAAALLFISSSNLFFPSSSGGSEDETMIGVKTSQTTEILFWIQKRLHLLMAHAPCVDISPSRPKQTLWQFRHFATQIGHFVKLASETLAPICRAKILAGTWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9Q1</accession>
    <name>A0A914I9Q1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Troponin I</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9Q1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8199.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8199.t1"/>
        <property type="gene ID" value="Gr19_v10_g8199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF1">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8199.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34618" checksum="5063C8EB852BF179" modified="2023-02-22" version="1">MLFFPPSKGAREDRSSPDIIVILGPQISEKKSEIGKMADTEVAPAPVKSDEEAKRQALAAKKAEVRKRLEEAGKKGKKKKGFLTPERKKKLRKLLMIKAAENLKNQQKQLDQERQNVLSKRIPQCPNIDSIEDKGQLEKVYNDLFQQMLKLEEEKFDINFFVSQKDAEISEITISVNDLRGKFVKPTLKKVSKYDNKFRKAAQAEGGESVSAGPKEDFRSKLKTVEKKNVMEVLEIKQKTKAEKPEWTKKVDKDAAGARRASQASSKGGGASEADAPATPKLPKPAPEEQEEEEEEEPDVAEEEEDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB34</accession>
    <name>A0A914IB34_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB34"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9197.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9197.t1"/>
        <property type="gene ID" value="Gr19_v10_g9197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037204193" evidence="2">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9197.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17523" checksum="520A1F32C544D2DF" modified="2023-02-22" version="1">MTTHHQNVAFLVFLLIIVLVQQSISDVPFDDSPQSSSDQSSSDGERRRPMQPRAISRSMLACRKLDELTGWVAVKAAINTMENSAKLNQCSTIYEDDDDDGNGIDRLSNPKTNAQRLNRATAFIGHRFRTNCVEDGKCRYVTNSTAKLYTTFSSDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB68</accession>
    <name>A0A914IB68_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB68"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9220.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9220.t2"/>
        <property type="gene ID" value="Gr19_v10_g9220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9220.t2"/>
        </source>
    </evidence>
    <sequence length="652" mass="76439" checksum="C54F8793E298A6B2" modified="2023-02-22" version="1">MFKQRSKQNSANNIFLRTMINIEHPTIYDLVIAHFCREYRPICGFHRVAFKQSNYCNLTNFMLQLMNRVKESPNFSEYFVHAEFPKELGQKLNAKVINGYQDFLHFAEAVHVNWNPYKELLITLHKFIYLYLCSKNGLEYFKNIINRFDQKELMKDLPKEFGEGEDVLHRKDLRSSVRFQGLSLPFKDEFHPCLTALFAYLLNMSGFWLIPDYWTTIYRSGHVERGRLSENFISFPESTHSYIGYWISSEKIYHEAYGGVFAELADDRGVRYCGIFADVYQNKSAKICGSFRVLSNKLNALPGKNPFEFVPISVAMINPDKAVEYLDWQIARYQLHIFQITANSLERLITKRISSNFWTMSKCCNVQPHLINVIYMKMFPHFRQQQQQQHGGQSQQRDQEQQQPLLELQLWHSQRHKDPNMRMMIMTNCLELALNGTLLSKKLPTQLDKWKALKHICNRQCQAITYVRKEKMNPSSIGESSPCRTSDAVKSPRKTLAEFFREDPLDETNDKEIEENAKLNKNSSVRDLSNEEIKELIGTLKDSNLRFSLNANKPREIGDPKKSKDKKSDDDVGKLRRLHKVRVKEIGQQSVYDQDPFNENQALSEEEIEEILQSNHLHSSRITIPSHEQQIVEQNFEKPSARQKRIRTVRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB74</accession>
    <name>A0A914IB74_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Proteasome 26S subunit ATPase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IB74"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8283.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8283.t1"/>
        <property type="gene ID" value="Gr19_v10_g8283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000075">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="209"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8283.t1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48503" checksum="D9FC31B10C10FA0E" modified="2023-02-22" version="1">MSSDIAEKKETNPSDAEEKTKEVKALDEKEIAALNSYNMGPYAEQLKQAEKDIDEIQKRINTLCGVKESDTGLAPPALWDIAADKMAMSHEQPLQVARCTKIIKEEGKDTRYMINVKQFAKFVVDLHENVAPTDIEEGMRVGVDRNKYQIHLPLPAKIDASVTMMQVEDKPDVTYADIGGCEEQIKKLREVVEFPLLQPERFTSLGIEPPKGVLFFGPPGTGKTLCARAVANRTDACFIRVIGSELVKKYVGEGARMVRELFSLAKTKKACILFFDEVDAIGGARFDDGKGGDNEVQRTMLELVNQLDGFDSRGAIKVLMATNRPDTLDPALIRPGRIDRRIEFCLPDLKARGNILQIHTKRMSVDRNIRYELIARLCPNTTGADLRSVCTEAGMFALRARRKVITEQDFLKAVQKVVKSYAKFSSTPAYMTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBL3</accession>
    <name>A0A914IBL3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBL3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8704.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8704.t1"/>
        <property type="gene ID" value="Gr19_v10_g8704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8704.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31423" checksum="4B2B9686C260DBF5" modified="2023-02-22" version="1">MCAETAVQRRLGAEAGQCGNVSRRTDCFAMPLPEMRERVWNPALEGREDEVSAEGAEGPSPDEKSLSLANAAAIGPFLFAQLRQQFFQQPPRPFRPLFPLAFPPPAFVPPPPPPPSITAAANRPPPTAIPPPFLMVAAMMAAAPRAVHGGTFVTPPQQLFRMFGGPIPTTHLLGHRMAKTREAKKRKKVPTKMPKTGQNAEKDGSRAGDEQQNSKKCNNPIVQMVLNTAAEDTATTAVNFNTCAICGAQFRLTGDLIQHARTNHRQSSRYDRNAQRASIAEEAQKLCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBT9</accession>
    <name>A0A914IBT9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ethanolamine kinase</fullName>
            <ecNumber evidence="5">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914IBT9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g849.t1">
        <property type="protein sequence ID" value="Gr19_v10_g849.t1"/>
        <property type="gene ID" value="Gr19_v10_g849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g849.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41603" checksum="59C6B7418DF5FD1D" modified="2023-02-22" version="1">MNPAAKSAPFIELELPHDAVEEHLDLYSERSSSSLFSQKIAALVGQIRPEWIRNKSGVDIEIYTNGITNKIFCLNHTESNEKMVIRLFGVKTEQLIDRNSEMANFERLHRAGLGPAVHARFINGFACGFLPGTCLDMKNVREPAIVEKICQTLARMHKIPLDTAHENLPMFGAKCADWLANLPTQFAKPEVQQQFDQNFRGSSLSDQLGRLLTVLELFKSPLVFAHNDLLIYNILYDEDGTGEVHFIDYEYAGPNYQLFDVANHFCEYAGLDDTPDFELNAATEEERRHFLRQYFAQFQQAIDESEMDKLLWKVRHFEAAAHFFWTLWAIHQAAISAIQFDYMSYANTRHRNCTRIMASLGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IC96</accession>
    <name>A0A914IC96_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IC96"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8562.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8562.t1"/>
        <property type="gene ID" value="Gr19_v10_g8562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8562.t1"/>
        </source>
    </evidence>
    <sequence length="536" mass="57532" checksum="C4F53D0D0C488987" modified="2023-02-22" version="1">MAFEHDQFARFMAPPPGRNGHQLSVVHPQQKPPVLARPPRRVVAKMDDGTAAKRRRALIVVTLKLALLCGWLLHELIVSFDESQCLQIATASASSASPFVPSSPHNMAQAPLLSSTAAANRTETDAKLEQYRQFGPTGGMLGVRVPLNGGQRSSMPSPPTARSPFAAAGAVEEQHQFHRTDSKNSAAPPPKRRRKVILRRKLLRKGASTVNWQQQKKKNGGGGIVNGGAATVRRVVWRVVPLKRLPPATKDAGAGGGGDGGVRLPAGDDGEVRRRLDAFPFENEFAAVPSAVAGDKTGGGWPLKTKTGTVVVRPDGGRRMARRRTAPEEENAVVVADTASTDEAAAFDWTQKNAQNGGPPHSFRVPLLQQSESTISYQLITLMNVGFCFVRAVFDCWALLQCFCCALFLLGLYLRNGRLALVPTAIDAFSIVLAVLFGLSLVIFMLILLLLAHAVLPPSSLFRCVLFTVSVNVAVTLFALCVFSELNAVAEMTKGRRRRAKGADDEPMAVSAADRAATEWGRSGDDNDAGGDGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDM6</accession>
    <name>A0A914IDM6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDM6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8928.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8928.t1"/>
        <property type="gene ID" value="Gr19_v10_g8928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8928.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9003" checksum="14955C43E20B6C08" modified="2023-02-22" version="1">MVFLQCLLLAKRMKVPPLFSPNPSSLDISGLGQLRHLCREEEPPSSSTRLGGEIEPAGLSVKRREWLGRTAAGPWAFSAVGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR83</accession>
    <name>A0A914GR83_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GR83"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10559.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10559.t1"/>
        <property type="gene ID" value="Gr19_v10_g10559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037586182" evidence="2">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10559.t1"/>
        </source>
    </evidence>
    <sequence length="419" mass="44507" checksum="75D8179EC3FD7742" modified="2023-02-22" version="1">MARFICASILIAFIISVPIEGDSIDGPGHNGKGPIVPGHNGNGPVDLGHNGKGPIDPGHNGNGPIDLGHNGSGLSLVEPGQNRNSLIEPGHNKGPNKGNGASSPASAGVANGTHLRQKRGWFAAGLAALSIPGVWDTAVGFVDWGRKQGCHGISAAVCSTYAFCRPSTGKLADLCCGDNMELTCTPPDELEVPVKPDEVEVPVKPDEAAATTTDTRTIGYDDLEREFSLVACDVGCCNKVPQEMVEENKCQAGQKECPCGWAMCIEKNGWMGSECCAAGFDIKCCAADSRVKASTEHCVFPYECPRALRTCVNLDASTVLCSCAYIDAVKCSKVDKVGKSNTRACYIQARALSCNWQKCVTINSDISYCDCYEFSVEKCPAEASDNNETIATTPTANTSTMVSTMNIFSVWLMWMAIWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR94</accession>
    <name>A0A914GR94_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GR94"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1001.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1001.t1"/>
        <property type="gene ID" value="Gr19_v10_g1001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1001.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31858" checksum="6E6A469B84EEA580" modified="2023-02-22" version="1">MTSWIHCNRCSKTPFNDKMRLWFASCGHLFCWDCLKTQHSISGQPFVCMVCHRNANLVEVNRHLKPELMALFRQPKDLIDEYSAKMKQIMAFQQFHRQRYNEYLLEKSERATKYAQSVKKEAQKSVEMELKLSTECDKLKAELERYKEHKCQLEGMLAKTKRELQHFTKRHHHRSTSDYATPATVADFPYSRRSFTGHSAQFNVPPVVIASSSSNTTAVSRRSFSYLSPATTSYNRSMGSARSAPLLPGRITKGPVLPRSLGIHRDRGNSDTESFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRL3</accession>
    <name>A0A914GRL3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g10660.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10660.t1"/>
        <property type="gene ID" value="Gr19_v10_g10660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cullin family profile" evidence="9">
        <location>
            <begin position="146"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="820"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10660.t1"/>
        </source>
    </evidence>
    <sequence length="1328" mass="152976" checksum="B01FF56AE8170722" modified="2023-02-22" version="1">MLERPVFHRNSAISRIKRLILSFDAYSREQFSKELEKLVRQKLLHIGMANALLIEKKYPSRSVNTHDILKGYATIVEYLSQCDPSFVLVHRICRIIRDYVKQRPDTMRTIITFITTEKPGDNQSSEMAIANANRLTLMLDEDQLQEVNDEYVIMVDDNLENRWMDWTPDPIDANPKESRLFRESADVFNMLVSIYGSKDLFVNEYQHLLAERLVTNGWSRHLQSEFNYLETMKRRFTDGELSHCEVMLRDIRESCKLASYANGSMPFSVCPRIVSFNYWPEVATSPLNALPMLPVFKEALVCYTDTFAQHKPARSINWYTDHGSQVELELELDGRTVQVDAPLPQAQIIILFTEKGKFCYLRNYTIKLVVLPFVTPYVSSERWDVALLAEASGLDMPDLKKRLDWWTSKGFLFHGPLDPITLEETVCLVTTSDAIESYIRQRGALHDYMYSDEEEEEQPPIEDVVEELEQYWNYTKGLLMHRATCEPLTAQFLHRMFKNFTSPGKTAPSLEAVQMFMQRKIKQNLVEMFPELDLTQIIAEFGHLTPEGLADVVIDRMALIPRKKHGMKRKTDEDDNDDVHSEYSSFNSETSGSDDLLVEKMLAELLRSCKTELRGERTVVDTSAWTGVKTLMIENFPLIRADFVTRMIRFFNGAIVPTAIACFFVENNFGNKLHKIAPSLTQTFWCKMAVPVQSRGRRFKQAYVSDQLREHFKRYNELMEQYQKKYPELLSGLKLTKQARNIPWERSEHEQWVECLVCFERVTMRRMVCCTPPVDSPSDNSFDASLVSTELCKEELELPTELTAHNQQTDSVLVIEFSSELSSSRVSVLEKEEEESDSPAASHAFCRCCIRGQAQAATDEIPLAEGGVGLKCMVPGCLNPILYSDIRTLLKRDVRKKLDERIVEENIGMASLQNLERCKLCNFAMEMEVDKSVNKVFDCLNCCAKFCRFCERRWDEDHFGVSCEELDLKTKKDKKDRELEKKLNEAVIRKCPRCGLPFMKDEGCNKMTCRCGMKQCYLCRQSNIDYGHFCRHFRDPKVTNWKCNLCNKKCLLFQDASKLDSVMMDQIRKHEEEAERQLAKEGTSASAGEQPPQLDQQPTTSRGTAGGGDATTHRKRMETLKERSYLPIPLGSRRSVWKHFPDNRQLNNGITTELRLYKVLSDDPFVRFPLNAVGFQQPVPAPYQPNVPPPFIQTSPYPPRDPRRLPFPPQDPRIFQQQGPMFFNQTAQMPPYPQDPRTPPFPPHDPRMFQQQQGPMFFNQTAQHPYPPTPPHQPAIVPQPTIAGAEMMMPPTGRIDFAFAGAEHAIQMFFNGGPTAQQQDQQQHNQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSI8</accession>
    <name>A0A914GSI8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSI8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10360.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10360.t1"/>
        <property type="gene ID" value="Gr19_v10_g10360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000336">
        <property type="entry name" value="HLH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000355">
        <property type="entry name" value="Uncharacterized calcium-binding protein B0563.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10360.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28136" checksum="D02DBA31D995B6A8" modified="2023-02-22" version="1">MNGHELAVTSGGLLSSMSSSSRRPSNSRNKSGTGGTTSLHLLGMGTMAASGSSGRGALFVGSFRSKFTTAASELNSEDGSNIPLITKLDKYTADELKEYRQVFNMFDADRSGAIGLDELENAITNLGMDPKQTDVEMLMREADKRGNHQIDFDEFCEVMKATSEKTQSWNEVTKECFSVFDRSESGLIARKDFEFVLRELGDIQNGRLIEELFMEYDVDSDGFIDFDEFSFLVRNYLTDDDVCNLGPSDVHEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSW0</accession>
    <name>A0A914GSW0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSW0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10083.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10083.t1"/>
        <property type="gene ID" value="Gr19_v10_g10083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10083.t1"/>
        </source>
    </evidence>
    <sequence length="433" mass="49651" checksum="7B33888C1263487F" modified="2023-02-22" version="1">MSDNVNDKEQQQQMAEICICADVWLEIFDFLGPFELGLKMALISDRFDVLVDVHFKSREWSLGWLYILRATEGNGAQIVNYRSDELLPIPQGPLPSKVIGFECIRICYVDQTVIEFLQRIRRLFDFSGTDVYISTNEDQSRGWEIIWQQIWPFFKDNICVFFLDSPQFDHLRPFSPAILRNCANLRSIVSFGLSAEFPAEDNAEASSDQAVAKWLITPREDGLPKTLRCDFDLGAMEGLKGSFVNASEPVTFIISIWMDDADFVPFELTNNWTGERLTFRRLKNTWLLVRCPITREENKWGKWEKEAIELDWDYQQQWNRITIDFNDTDIGDGMVNENEGPNLDRLRQFSPAILRNCANLRSIESLGLCLAFPAEDNAAASSRQVVAKWLFTARKDGRPKMLMCGFYTGGMKGLNGSFVNASKAGQFHHQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT91</accession>
    <name>A0A914GT91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GT91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1106.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1106.t1"/>
        <property type="gene ID" value="Gr19_v10_g1106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="29"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="240"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1106.t1"/>
        </source>
    </evidence>
    <sequence length="527" mass="60980" checksum="D87B683BA2DBBE95" modified="2023-02-22" version="1">MKIIIVFNGIISICFSMGNVSLRDRLQRNIKKLPSSVENGPMKVRTGIYIESLGNFRATEMSFDVDLYLYLSWNDPSLRHSEPDFVMLNDPKIRQNIWLPDLYFPNAHISRFHEVIAPNLNLFISPNGTVAYSTRITLSVACNLELSLYPIDGQMCRIEMLSYAYVERQLLIRWFDNIEPTRHNPNIQLPEFRISNITGGYCNGSYKYAIMEHAYRTDNFSCLVALIHLNRQIGYHVVQTYIPTGLIVTISWVSFWIDRRAVPARVTLSFTTMLSLSTLGNGLRFGLPQVAYAKAIDFWFGACMFFVFLSLLEFAAVNSYMRESDKFERFASYIGKKNSTFVKELSRNLSIKMPKIPRKITEQRQNWEMNVKQQNEAATPMAEDEKSLGERTLSQCSAIEEIPTDFEGKAKNWSSAATVGESNELTVPMLDTSTAHRPSHSRINFNTARHNKFRPSLRPDRADIINANLREHRDLDGNPLITNHFLRQSIHFSRKGLQIDRCSRWIFPLGFALWNVCYWTYYLWYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUL4</accession>
    <name>A0A914GUL4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10926.t4">
        <property type="protein sequence ID" value="Gr19_v10_g10926.t4"/>
        <property type="gene ID" value="Gr19_v10_g10926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF28">
        <property type="entry name" value="BAND 7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="86"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10926.t4"/>
        </source>
    </evidence>
    <sequence length="477" mass="51830" checksum="D819F2C4CAB2150E" modified="2023-02-22" version="1">MFWWCCADFSNMAGIFGAERDAQFTSIFTYNSEQHYGNLYGDDFGHVSMPILSCAERTLSDRLLECTCTVLSSVFLVLTLPFSLPFSLKFIGPSERLVIMRLGRTKGVHGPGGTVLVLPWVDKATCVDLRVSTLELPVIQSLTADQGMIELVATVFSQVTDPLLAHCAIQNVKETLHSLAYVTLCRQLCKRLLCDLTQTTSLDNILAKCQEELNMFVRPRGVAVERLAVTRLNVLKPADTGGSAMSVLHTLARSQLGQQLFGQLSRNFLQQQQCPLDTTAAASGAIPEVIIDNKKDGHGQQRVTPTALSPICEESVDSSAFIPHALDSDLMALLKRIRPALGPPLVQRVQRLFRVRCAGDGSASASSITASSSCSTTTIAAALPPEFDIDLRSGDGWCGWTWERTGPLPPCDVHFTLQKCTLLSLVDGSVSPMCAYLDGRVQIVGSVQDATLLKHLADALVALPKRGRTEDGEIVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUT2</accession>
    <name>A0A914GUT2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GUT2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10588.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10588.t2"/>
        <property type="gene ID" value="Gr19_v10_g10588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF456">
        <property type="entry name" value="CD63 MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10588.t2"/>
        </source>
    </evidence>
    <sequence length="515" mass="57141" checksum="4C174C0C8910F137" modified="2023-02-22" version="1">MRIGSIGSLPRLHNCHPIFEAMRLRPLCAFQQNHLSTHQRWDCYICRSESKPIWAYAHLMDEQKIRNAIRTAIQSQQLQTISFKWCQYNPKKVKHLPASFDACAFTNPHSGKLEFVIATITVEQEEENKLEPLFEPHQQNIVNMNWPDAISLPGIGGVSSTSLNCSNLPMNPSNVYLPHSMLTSASDDQGRWLPQFGNTETTVGLDMAVNVGWDGRRVEAKGVGVMESYPTTLGPIPLGYSLPPLAKGKGSQCSAWLWEEEAPIFAFGREQRTTITPESYSAAGMVEGGITLVKYLLFFANFILWVLGLAFLVSGIVLQLKYTGLLDILGDERLATPVLLLAIGCLCTLLGFVGYCGAIRENYCLTVSFAVLLALLLLAETAIAILVYALHEPLNVTLINQLTQGMRRYNNSKGVLLAWNQVQRQLHCCGVNNATDWKTYAPDSCCVHFHDGCARMAQPLLYEMGCVQAVQHWIVTNATVIGCASALLGALQIIGICFACCLSKNILKDFHDFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVM1</accession>
    <name>A0A914GVM1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVM1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11750.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11750.t2"/>
        <property type="gene ID" value="Gr19_v10_g11750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="103"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="129"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11750.t2"/>
        </source>
    </evidence>
    <sequence length="572" mass="61356" checksum="F7703FB05CA2572B" modified="2023-02-22" version="1">MRARNRRWTEAAAAAIPFQNVFFHTAFVLLHLVDREACTSMSGSVMPGLSSSPLAWPSGGGGGGGAGAARAAPNLPLSPIGAENRVEAPAPAVGQQAKALLGPRVTIAEFGSDGYNSQGGGPVPDAISLNCDFEGQQPCCWANVPTPTDDQIDWVQVEGQPQSSVLPRNVSVDGKYLVAYASAAAPSDEAQLSSCAIACASTSIRVRARHMQTSNVLLQVCQRESFPPSLGFNPLLNCQEFPTSSGRMINTELVLPKASYVDIIFVASNFIGERGDVVLLDDIQILYDSNPPDCGAPSTTTTTTTTFVPITMVPKKKQKTEKKSKSSDKTIMEVDSHGREVDEDTEDDDGPDKVRRAELIPQVDGGQNAAQSAAAKGVEALKASSTTSTTLTTPRDLSITPEKACPDVQCSFEDGTICRYSNSFDTGSSAHGLNTRFEVVKGQFMNRVTGVKQGTEGNYYAAVFLYPREKAGLMTSLAGPLADELRVRFQYYEGTHGVQLKACCDTLEQCPFSSDRFVTVTDRMWRSASFACPKGTQRLMFMCENTRTNQGACAMDDIRVQDARGDGTQKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXN9</accession>
    <name>A0A914GXN9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXN9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12109.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12109.t1"/>
        <property type="gene ID" value="Gr19_v10_g12109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF333">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="439"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12109.t1"/>
        </source>
    </evidence>
    <sequence length="622" mass="69782" checksum="DF3C43ED5DFDB6E2" modified="2023-02-22" version="1">MALDIGTTDGGAERQKESKSAGRRFPSVQSTPPAYALLVLNSNPSLLGLMLYQRRPTYEMVQPVDEAEDPLDMPGTSSAASDDVSRRKISSHRGQRKVSRRMELIVRGSGGWLNAEDTFGELNEGMEPDELEELRDRLGDLVDPRESLQQRRRRLGVFDPSSVPSHPSSVCWTGGHSSMVHHASLGLNGEEDAENEVDDVEGVARGDSALKKYAKLILPHVALVLLTCAYTIIGAFIFYSVENPHEIASKRRQLDLINRQQDMFVSALVRLAVSNVSGVRDEWQHLARGHLHEMSDHLFIAFEKHFLTATEVKRNATISIWTFSTAVFFSVTVVSTIGYGNPVPVTRLGRIACISFSLFGIPLTLVTIADLGKFLSEHLVWLYGRYLGLKHFVVNKLQRTEFEGEHICGKCRSRGLSTVEGSIHLVEEKKIPALLVLAILVLYTALGGVLMSQLEPWSFFTSFYWSFITMTTVGFGDLMPRREHYTALILLYIVLGLAITTMCIDLVGIQYIRKIHYFGRKIQDARSALAVVGGKVVLVSELYTNLVQKRQRNNTLRDAFIIENLYVSKRHIIPFIPSDIRLIKYIDQIEPVTRNNSLSDPHLVPNSCRFCHSHFGMANHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXQ8</accession>
    <name>A0A914GXQ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g12124.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12124.t1"/>
        <property type="gene ID" value="Gr19_v10_g12124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12124.t1"/>
        </source>
    </evidence>
    <sequence length="1510" mass="166734" checksum="6ADE401EB166C411" modified="2023-02-22" version="1">MTISEKINSFGANSLLLPVVLWGPKSLKSRIVRISSVQNGRIILTGSTDGQVMQWIVDEALGWIQPQMVLLAHESAISCISPICSSNTSKFVTCSEDGAVCLWDSIDGRVIDSVKSNCIHRTIKPYTLKNGAQNILFCIGDYADVIVLHPYDLNVLFTLGSRIEPDWIASIALASPMDVLIGTSLSGVIKLWSLHGLDPKETGSVLFESESKVMGTDGVRSIVCSDKNLRIMLVVCGSSWQIIDPSTLNQLIVSECAIEALEGIIVDIDKVAIAFADSTIVLFQLPRRKLCGKQVREKFGENPANVFNIEQPFVFALLKGTLSSTLLKPSLAPVQFYFDESKNSGKKVAYRVDQQGSISLWNIPKNLEFLVNEFIRNRRPIVYEPTIKQHISEAWARLVPPPPTLVETEDDRTVTATIYVGTQGKLFHGFDDGSIMMMNACHAIMAQLLEGFCNDFAPYRLLADGHSARVNCFAYPFADSARYDPNLLLSGGADFAVIVWNITLGERVHRFCCQGGPILRFVVPPTNCSMRVLNSICAIAGDNSAALLSLKELKCILLASRQQFPIIDVRWRPLDDFLLLRCEDSSVYVWQIETANLDRIVAGLTTDEVMDACTEQLDISPGDDVENELFASHPVQILRALKQKNIAALRKIAGHVDGKQAEVLSSIELVRLSPPMDILQLHNCSDKAHLILFNIDSLIAGLLSLDCELCATESDGNLASANFDCLSGTDGRALFTSLITKRIATMHQGNGIYHLECERGEFGLLSSAVPSNTIKNPSNTSLSSTFLVQQQSLYMDTAKLLISLLHGWDFDEEVDRACLNSLKLCRPKLPICFGTVTKKGNLSLYTPYCSGKISALDDFSYKYFSRSVHWHESRALTTVHLLSIVALSNTLMTLKSKSNQLAVKKPPLKRNSSIKSSDFLAENESQQIRQGWSNVASLHCVLLSELIKPSDAYATPRIDLLARKWQNDCIEIRDAAQALLVRELTRLGSEGRRRLIERWSNFLPTVLDSGVLCCWTSARPQQSRESRCICRGKAHLNIQNESSASFVVVGGFADGLVQNDFSFCQRKHNQLQFKLDERQTRATATACGASDSSSDSQFRRPALVGLNKCSRLFNGRRVIKLMSQVSFQPPVNASLSSLDDPYQQCASSVLIANKLQEDQMLLCGGVHQVHRNQATSIVLLGAMGAEFPNDLQRNIDLCRATALSLLELLLTPESPLIPANSPLRRAAIDLLGRGFVIWQPHLDLSKTILGLLNLASAEGEKPDTSLPILFTSEADASRTARHALSLIALSRPQALITTLSTEVARYNAVAQHQTIQHSIQSPLMRARNEVLRLLEQLSDKQYNFVVDLIIPVGEVLVHCLDLPLLKQRSLLDLFPSIAKFYMVAYCPNTRRLAFGGKNGAIIVHELRASKAQTVQAHRAPITALAFSQDGKYLAAYAAQDAKISFWQTQQTFLGMGQSQIRCTKSVPAPGEFPVISPGGSYQPFRARLVWINSKSLTLMLPNGKENRFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYD9</accession>
    <name>A0A914GYD9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription and DNA repair factor IIH helicase subunit XPD</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CXPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">DNA 5'-3' helicase XPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">DNA excision repair protein ERCC-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">DNA repair protein complementing XP-D cells</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Xeroderma pigmentosum group D-complementing protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYD9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12335.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12335.t2"/>
        <property type="gene ID" value="Gr19_v10_g12335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035315">
        <property type="term" value="P:hair cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="255"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12335.t2"/>
        </source>
    </evidence>
    <sequence length="695" mass="79698" checksum="C8CC961AA155945C" modified="2023-02-22" version="1">MRLHIDGLNVLFPYEYVYPEQLLYMEQLKKVLDAPGHCLLEMPSGTGKTVSLLALVIAYMRKYPERLYKLVYCSRTIPEIEKCVEELKRLFRYYANVMGAPPEFFALTLSARKNLCINKSVVSFRHGSAVDGACQRLTASFVRAKRRLNPDLPCCSYFEKFDEKRDLTLPKGIYNLSDLREWGREHGMCPYFVARHLINRADIIVYSYHYLLDPKIAELVSRELSPKACVVFDEAHNIDNVCIESMSVTLTKTMMEKCAKNIDVLEQHIQTLKTENHRRIQDEYEKLVENLRRVEKEREEDERAWTNPVLPTEILREAVPGSIRTAEHFMAFMRRIMEYIKHRMRVKSVQIESPAAFLRDIKARVFVDRKPMRFCSERFASLSKTLELSDISDFGALVKLATFSTITGIRLAITPFISTSVVITSGTLSPLDMYPKILDFDPVVKASLSMTLARHCISPMIVSKGNDQVEITSRFESREDPSVVRNYGTLLCLHGECCGGLVRTAHDRRVTLEKYVEACESGRGAILFSVARGKVSEGIDFSHHLGRAVVMLGIPYVYTESRILRARLEYLRDQFGIRENDFLTFDAMRHAAQCVGRVIRGKTDYGLIIFADKRFCRMDKRGKLPKWIQEHLTDAQTNLSIEEAVMAAKRWFPLMAQPFTKDHQLGVSLLSKELLGNKQDDVMSKFRGSVVAEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZY7</accession>
    <name>A0A914GZY7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZY7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12918.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12918.t1"/>
        <property type="gene ID" value="Gr19_v10_g12918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12918.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13547" checksum="C663D9D23A3FCC48" modified="2023-02-22" version="1">MCHSHFENPEYGMTQKHAERNPISGTSYILYALSLPAYRSANLRPPAHNFIPRKAITPTSRGRRGGGGCAAVAAAAAAAAVPPFARPNRISAAQTFPFIPSSPSRTNSFLHNVRGTAQRHSHPPMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H028</accession>
    <name>A0A914H028_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H028"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12946.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12946.t1"/>
        <property type="gene ID" value="Gr19_v10_g12946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14514">
        <property type="entry name" value="DUSP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF9">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12946.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27853" checksum="C2C7C15E200BED95" modified="2023-02-22" version="1">MAPLSFQVNEYYAQISELVPGLYICGVTGLSSANMKAFRIELIVNATREVPNLKSLGQIQRMKLWVEDTTDEDLFPHFDIVADQIHAVIQDRGAVLVHCVAGVSRSAAICLAYLLKYRTRSLRAAYHLMCSKRPMVRPNLSFWRQLIHYEQQIKRNVGSVRIVRDEAQPDKLLPDVYLKNVIPDQLSRPLSPTNATDAAQIVPKLFSDESAPVTQPPSSRHRRNSSGGSARVKFVPVLGVLTEMAAESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H049</accession>
    <name>A0A914H049_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H049"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12002.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12002.t1"/>
        <property type="gene ID" value="Gr19_v10_g12002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12002.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39787" checksum="4D71E4EEFE086A26" modified="2023-02-22" version="1">MAHFENDGFLFPNFINEKFDGFTYKTSPLPLPSAGAIIQPMNAFFEQFFATEESLDFNEWERALPTKAERQQMRKLIHFLFRLNDFSAISSDPLFLQRFVPILAKSVQLSFIGDLFCVIHEHFPPVQFRRFARFWGYTVLTAPAHSLRPHLHHSAPHFESDGNVCNQSASLFERTSSRSLVIAGANRFAVCGKVSSSCQPHFTVADGAHNDQTMFHTMCTALFEADKGEGTFVQWHGMAQTSCDGASAFVSAGASKGHPIYAKPGAALNRLVNTVNGLLGESAVTTPDTEPKCRLVASKNIFGRMINGVPIGRECNTAAQTKDVKGRFIHVEQKSELYNDWKTWTTALKKVFPIGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0E1</accession>
    <name>A0A914H0E1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitoguardin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0E1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12464.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12464.t1"/>
        <property type="gene ID" value="Gr19_v10_g12464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019392">
        <property type="entry name" value="Miga"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508:SF5">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10265">
        <property type="entry name" value="Miga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12464.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="51005" checksum="ED0768F6E868B027" modified="2023-02-22" version="1">MSELLSIVQNQPRRALIIGAGIGASVFAIQALWRYFFTERSGKKLPRLRNEKWKLSGRCEIDISSLNAAIDNLELLLAELEPNKFQSEFGRGKYDLVASIIARLRGVYSDLQKYVSDDFLKRVSTEDIARSVWHTRSIVGSRTGGAGTLSVLSDSSFISACDEFVAVQQAPTQNENRQPSLSIDQSAIPLYNQGLQMAQRGEVRFRKTRAEFCGCESDEDFAAKLYGVRLAFRQIMDEPQTMQWLIQSGRIIIADLLRHDKRDPAEFFSVYDRMTAFLLDDKNLATVCEELKMRKVESTNLWDVLFDLIILDAFEGHLQKPPSSISALLRNGFISTSMKESTLNNLIWSMIKLKRQRLQVKNGFIAHFYDISQVLTCSLTMGLIGGSAKEFQELCVYFKEQIFAFVLDIFNTSKVRYTTIGQLTEDVKKLLTDRIDLLKVKLSNELLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H217</accession>
    <name>A0A914H217_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tubulin--tyrosine ligase-like protein 12</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H217"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12949.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12949.t1"/>
        <property type="gene ID" value="Gr19_v10_g12949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057954">
        <property type="entry name" value="SET_TTL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027749">
        <property type="entry name" value="TTLL12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25556">
        <property type="entry name" value="SET_TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin--tyrosine ligase-like protein 12 SET-like" evidence="3">
        <location>
            <begin position="64"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin--tyrosine ligase-like protein 12 SET-like" evidence="3">
        <location>
            <begin position="153"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12949.t1"/>
        </source>
    </evidence>
    <sequence length="658" mass="76194" checksum="4B8D1D2B6E909116" modified="2023-02-22" version="1">MTQLLSYKQFLQIHEPQLLAAGLLELFWKNLHEKLVNQIFDAGKYFEVIIEENDPNETISSQVKALSDLRVDDPKNVFLIDHAWTFRPNSARNALRQVDGLRKRLTDMFNIKVAADDPSSSSFFAGDDPSMGADCESSSAGNDQNGDELTEQSQGAVDDRIMDEIWKYAMTYSVRIRNAEMDEGQIPLWYLVDEFGIRIGHSLQPNAKMVPFLNLSDQMTYSLLFPVQNVLADDIVTRNYVDTQLAKDHPDWFDVLLHPWQPEDNFADRSICHAPKTNEYFMSGRLHDLVPSGEQGAKTNFRKSVDDPNILVCASDLQLIEKLRRICVEETTDPMRADIIWRRDHFNDFRLLAEQNPGALINQFPFEAILTVKDLFAAAVQSFVDEQQNGLNVVQLVDELSLRWSPQWFPLTFNLSMELPQFVAYFQRRAQKNLDNCWIVKPWNLARGMDTHVTRNLNSIIRQAESGPKIVSKYIENPLLFRRLDSGNLVKFDLRYIVFVRQLCEPIDIVVFNQFWIRFANHEYNLRNLDDHFAHLTVHQYGDNKANVYQLRCDEFVGQLCKQYPKLKWPEVQEKINAVIVEVFRVVTKNAPPRGIAPNRQSRAMYGLDLMLHWRDHDDSDGLCERPPVDELGAEDVRVAFIEANFMPDYFVLREDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H270</accession>
    <name>A0A914H270_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914H270"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12988.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12988.t1"/>
        <property type="gene ID" value="Gr19_v10_g12988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="12">
        <location>
            <begin position="488"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12988.t1"/>
        </source>
    </evidence>
    <sequence length="817" mass="91465" checksum="F8AE2A340E71D8A6" modified="2023-02-22" version="1">MCSNPNAKVLSSICGFSRMGPNRELKTRVESFWKEQAKLRFDGSSNAELTNSIDKFEKDIEQLQILRWQQLKATGVDLIPSGDFSLYDHVLDCACLFNAVPPRYKTAAELNGVPSHLRLYFAMARGLQEKGADVPALPMKKWFDTNYHFIVPELSTDQKFSVGFNKPLKDFLLAKSALNLLTKPVLLGPVTFLHLSRVGERKELATEEQQKLANLKLLSSLLPHYVQVIQSLVDAGAKWIQIDEPIFSLTFADNEAPTYYEAFRKMAQTLQQVTAKKAHLVFTTYFNSIAKNVQIVKDLPEGTGIHIDLVRAPEQLEPVLSALPPNCFVSLGLVDGRNVWLSPLRQCHAEALRVVQRLAPGRVLVSTSCSLLHVPYSTKTEKRNAEVPKTVVTGMDSSKILHWLSFGIEKCEQVVTIAKLLNGVDCAKALEENDALLKDHSVSTLIHNAPVKKRVIGIEASGIASYFRQTGYDQRIVQQKTCLKLPPLPTTTIGSFPQSATVRAMRAKFKTHKMTDADYWAFINAETERCIRLQENIGLDVLVHGEFERNDMVEYFAEHLHGFCVTSNGWVQSYGSRCVKPPVLYGDVQRAGPMTVAMTKFAQSLTKKPVKGMLTGPMTILKWSFVRNDQPQKDTVFQVALALRDEVAELEKEGINCIQMDEPAFREGLPLDPAHHFDYLTITVQAFKISTGCVADSTQIYSHMCYSDFGDIFTHIAELDADVLCIECSRSDLSLLSCFDRFGYPLMVGPGIYDIHSPRVPSVDELKARLRAMLKYIPASRLFANPDCGLKTRDWPETEAALRAMVDAVRAVRAELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H280</accession>
    <name>A0A914H280_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H280"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12993.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12993.t1"/>
        <property type="gene ID" value="Gr19_v10_g12993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12993.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="29262" checksum="085B1501DDAFAB45" modified="2023-02-22" version="1">MIIEFIRKAFREEMVMGMMRSLKGGQKTWHFIELWTNFRENDCKISEQVTIKTEQLKLCNNEADHKFGKFGEAFVKAEFKKVKKHEINQCRTMMASKIYDLKWELAMLPRELAMVPRELAMVPRELAMVPRELAMVPRELAMVPRELAMVPRELAMVPRELAMVPRELAMVPRELAMVPRELAKVPIPTMTKKQYYYSDKEKSELVKQFYELKEEYIRRGDGSLLTGNLLDKKTARLELDSARKKAIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2B9</accession>
    <name>A0A914H2B9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2B9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1302.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1302.t1"/>
        <property type="gene ID" value="Gr19_v10_g1302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1302.t1"/>
        </source>
    </evidence>
    <sequence length="841" mass="91785" checksum="D7E797FC173819A0" modified="2023-02-22" version="1">MSGKKGADWYDESDRDKMNMLSACAKGMVAEVERYLNGDVDMEEEDDDGVTALQIAAAKGHRSLVELLLRRGAQVDRANYAGMTPFLHACREGHQDVITVLANHGANVNATTGLGVSAMALACAGRHIGAVRTLRGLNSAVNSVPSSRTVHQVAPSPYMVAFFQMDIEICGFLKKNDANVWHQIRWMDGMDAHKLGETLHFPPILMSLNYAENSLKAPKSAKDIRSVIQTGDENELDHWMREGRVPPAISDGITPLMYAAFHAQHRIAEQLLKSACRSAIDAQENVLGLSALMLAIVVGDNSMVQMMLRHGANPRLSSTTKEPFTAIDLSHFSGLSHDTLFKLYKQFLMSGKGEKNLKRELSDKKEVSENGGKAQLGERKSSATGVALAKLGGSAGGGGVPSPTSVAGGGSQKRLRRVIESFTRNIIGLTGDLSGQISGGTNGNDSFPLAHFPNARARFDALVDTANLNGSDAPRFVLAEQILRGDARAPATTIARAKALQLDARIVLARQIAISWMVRGDTLRPMAFEDGLSQLKNAEESAEVNGLYLAAQWNAEKLFKNAPMKRQRRKTDPSQATAQSAILNVRLPLTPQLIVRTANSRGNEQQVQKSPSSVSRHKVLLSQCERTTVRKAPHRLGGHQRVASSGSGGTGPAYGSNTTSNSCGSAGTMSTASQSQPDSPQATLDVATVWEPMGKSNSIPPRPSIFRVQYHHHFQQQDASETPVEPPQQKLYNKQHKNGQHSPNTLALQQKMPRPLTKELIQRKVYQWDLQEEFEQCFVAEEVDELTFASLRETEIQEVLSRHGRANDLLVHQRFLELIADIKRCTGYLSIVPHSVVFDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2T3</accession>
    <name>A0A914H2T3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2T3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13463.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13463.t1"/>
        <property type="gene ID" value="Gr19_v10_g13463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13463.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33465" checksum="84CE6C05D45E7A18" modified="2023-02-22" version="1">MSEKDSPEGAQPKQQQNPPLDQTVTDLALQQVQMGLNVFWLIQQAALQQQQQQQQPVAERTSSSSSLSKQQHSSLYSALSTVLGEASSSPIRPTLSPQQPQQNSNGIPTKEDKRRRDLSIIGKRWEYVSDVQSFAEFEQLRCRHQVSRNRTFAHGIRYSCTQKTQLRSNCPYLLLCLFSDGAGEHSAPGVGTISVYSRNKHTHPVKVIKARQPRRFAKLAKKERKGLETNEEDRSGKMPQEATEAEETVEKGLKIGNGTEREEEKAINGRKSGGALVEMLSRMLAAQQKQNGGGNAQTGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3J0</accession>
    <name>A0A914H3J0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3J0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12933.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12933.t1"/>
        <property type="gene ID" value="Gr19_v10_g12933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12933.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17234" checksum="EF51263ED77E7C4F" modified="2023-02-22" version="1">MSTEPVIKHTHTLPREKFPNNLWLKERNVRDGITLSVFGTATVVGVLYFTKPTWSRIYSLFRSGQCHKKPVSSSISGSGKNVLLHPQSKRLDQTAQHSTFPHNMVSPTVHRRFVIAGRIFFVAVVLFALRLAQVDKRLVTFAEHIMKEEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4Q3</accession>
    <name>A0A914H4Q3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4Q3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13221.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13221.t1"/>
        <property type="gene ID" value="Gr19_v10_g13221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13221.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12181" checksum="A3BBDB99001F43F7" modified="2023-02-22" version="1">MLWFGKRIGRSFAGIPSIRPPGMGFACGEFRPSDRRGWDSPAEFISPILSELALANSILARPSNLLPVITRCLGISLETETHQSLVRLCPLNEERPTGKQPKATKNRLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4W5</accession>
    <name>A0A914H4W5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4W5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1419.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1419.t1"/>
        <property type="gene ID" value="Gr19_v10_g1419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1419.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8284" checksum="F9E86D5FC7DE6C19" modified="2023-02-22" version="1">MRHQFGNAPNHLHEKWRAFRTANLFVSNSASDLFPFVMLSEPGNKIEANFGPNFKFNIRSDQTDFMAFYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H555</accession>
    <name>A0A914H555_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H555"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14255.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14255.t2"/>
        <property type="gene ID" value="Gr19_v10_g14255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12423">
        <property type="entry name" value="RRM3_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12425">
        <property type="entry name" value="RRM4_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000341">
        <property type="entry name" value="Hephaestus, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="458"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="575"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14255.t2"/>
        </source>
    </evidence>
    <sequence length="652" mass="71314" checksum="1AA9C9A54288EC09" modified="2023-02-22" version="1">MLIKKSFYNQRSPSHRALASLTASNIRHNLFTSSPDLRQPQAIHSFTSVTTSSIPSSTATFNPGQKRPQPNAGTHQSNSVQHLQQILSANSCYSLLHNSSSSLFTTLADATLLQNTTIVNEALKTLGTIQQQEIAAKRIRFGPAFAALAPTLIPVSTSLNHSSAAASVIAATAPFPAITTSTIVNSATQHQQMALSPYRQQKTHVQLEAIELNNTNGNINGNINGTVVSGKELCGTDFVRYADEQQLDPNGAVALQCLDGSGLSQSYQDLSVGVQALPNSILRIIIDYMLYPVTLDVLYLIFSRYGKVLRIITFNKNNLFQALIQLSEAGSAQNAKNSLDGLNIYNGCCTLHIEYSKLSTLNVKWNNDKSRDYTNPNLPSGDLTYEQKLQLLLQNAHTNNGLSAMIPLATNSFPFNAVTLPQATNLAQNAQILPNNLAGIVLNSAAAAAAAQFQAGTPVVLVSNLDETAVTPEQLFLLFGVYGDVIRVKILFNKKNNALIQYADVQQAQLAIQHLDKVKWNSKNMRVTASKHIVVQMPKEGQPDAGLTKEYVNSSLHRFKKPGSKNYMNIYPPSSTLHLSNIPSGMTDDAMLEIFKNFKIVEFKFFQKDHKMALLLLEDVESAINFLVTMHNYKLAESAHLRVSFSKKGING</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5X0</accession>
    <name>A0A914H5X0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heme O synthase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5X0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13514.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13514.t1"/>
        <property type="gene ID" value="Gr19_v10_g13514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000006">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13514.t1"/>
        </source>
    </evidence>
    <sequence length="407" mass="44892" checksum="627B6A05A7A2D5C2" modified="2023-02-22" version="1">MLSFTNRTLLCKHFSIHRNCSSHSAVKANQRILTELPTSSNAELKKCKSEIRKRAKFFSVAETRESEDLRTDQQLIALKKPPIVVGNSCSLLHAYLQLSKCRLTALIACTAVSGFVMSPAFSSAPSSLFAACVVGTALLSASASTCNNVIERQHDSQMRRTRSRVLPVGRLTPVHALLFAAATGTTGLGILCLSCNHLTSALGFINLALYAGFYTPMKRRHHSCTWIGAVVGAIPPLMGYAAVTGRLDSAALVLGALLFSWQFPHFNALSWNLRGDYATAGYKMMCVTDEGLCRRTTLRHSFVLLSLCSLCAPLTHLTTWTFALTSLPLNASMLFLAFQFYSNPDKRSATNLFRFTLLYLPVLMTLMYVSKDMCPKEEDSFVEGIRSCRERAEAAFLRIKSFEKVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5Y0</accession>
    <name>A0A914H5Y0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5Y0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1352.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1352.t1"/>
        <property type="gene ID" value="Gr19_v10_g1352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1352.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13228" checksum="9C89A9D28F7375B8" modified="2023-02-22" version="1">MTSSDYGDDEARGDGIKAPPSERFLNYSLFHNYSPYGTRSLAYDYAKFAERTKWPVKNPCGTIQFDDEPRLPRYQYWSPLTARYEVVLLFILQITYSFLSINEDSWRYYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H693</accession>
    <name>A0A914H693_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H693"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14208.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14208.t1"/>
        <property type="gene ID" value="Gr19_v10_g14208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00698">
        <property type="entry name" value="TMPROTEINSRG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14208.t1"/>
        </source>
    </evidence>
    <sequence length="329" mass="38399" checksum="3B2B02930D76E7A6" modified="2023-02-22" version="1">MLDLIIDQCVSITITMPSLFLYILECWFIFRGRNNKYEGSFYRIFLLSAINNIFINFLLTLFTFRLQTMSALFALFLSIPSWAARIFFALYYYNLHVESLLTLLILIHRLSAIVTPLQYEKVWKKLLPYVSTMTFLFPLIFVYHIFFIEVCWTPYTTDGEEFIGLDYNHKAYPNAPSNSKLAFIISAIFLILCLSMNVAILAAYKRVNAKHGNANEHNAKIEFRLMLYALLIFMIQAFVCIFWVAIYMFEFDDSLFTHIIGHYILLNDLRAFVFPAWFLLWASSDIRKHVQKFVFCAKKMSQNASLMVNNGSAQKQIVPIKSVNVVTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6N0</accession>
    <name>A0A914H6N0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6N0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13722.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13722.t1"/>
        <property type="gene ID" value="Gr19_v10_g13722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13722.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="16564" checksum="ECE73BCA57D3A59F" modified="2023-02-22" version="1">MTAVFKEMGQENNGGGGGVGGGVGGGVGGSVGGGVGGGGGGGGGGGVGGGVGGGVGGGVGGGVGGGPDFSELTLIWNAEKSHRQNWVSAWIIWTVAAGIVITVLMIGAGALMWRKRASKKVSFPAVETSTAIARAIAMATAIAGATFAMCAPWKLLLAELGKAIARRKSLEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6U7</accession>
    <name>A0A914H6U7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6U7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14363.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14363.t1"/>
        <property type="gene ID" value="Gr19_v10_g14363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037356893" evidence="2">
        <location>
            <begin position="25"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="63"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="299"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14363.t1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56614" checksum="BF7B7D52E6B363FE" modified="2023-02-22" version="1">MPTFLFLAAICLLVAASILLETDASPKNKKPKLEKGSSSSGNAESTPVPKANSSAGLRTDHRADVHFLVGDIKELLPAHKAILAEASDVFERMFRFDEANAKSAAAGTGSSEEIKPVEMPDEEVGVFKAMLAFIYADDLSGLNEDNAISVLYAADKYNLPKLVNACLNFILKLNVFVALDEARFFGKKNAETLIRSEEFLQIDQKLLCEILDHDKLIIFEELTIWNAALRWADEKCRQNEEESSAKNRRAMLGPALFKIRFPLIPQKDFTENIVPSGVLEEDEQAGVYQYHSHPNAGLPEQHQLQFPTNIRDTGLTIQNRWDSAACHRDLAISEPARLIVQIIGKNWEWRSVFAERPIPKGKFGIFYYEVKILEKEGPIYIGLGTKRMPSNKWVGGYKGTYAYEYCGRFWGHEVEGCSHLNNGRPYIFRKPSFGVGDVIGCGVNLATRQIIYTKNRQRLETTRLFVDFGAELYPCISFYYPGNKIEANFGPNFKFTLPKAFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7Y5</accession>
    <name>A0A914H7Y5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB/POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7Y5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14648.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14648.t1"/>
        <property type="gene ID" value="Gr19_v10_g14648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="299"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14648.t1"/>
        </source>
    </evidence>
    <sequence length="438" mass="48677" checksum="C38A45DB9935E48B" modified="2023-02-22" version="1">MSKSASSVDRMKRLLSTGNGADVHFLVGEGNEKELLPAHKAILGTASDVFEAMFRFDAESAKFAVGTASSEENKPVEVPDMEVSAFKTMLGFIYADDLSGLNGDNAIAVLCAAKKYDVVGLVDASVNFPVPKLCNVFIAFEQARLLGEKDLAHRCLAYIDANAATLLLSKAFLHLDQKLLCEILDRDQLMISEEIAIWNAAILWAEEKCRQNGGERSAENLRELLGPALFKIRFPLISQGDFSEIIVRSGVLTSDELVGVYLYNSHPVHRALPSLYPLQFPTVQRALTKSRDDDRYKSSGKIRLKIEKVSEFSRENENSRRLGESVYIRGLPWKISAQPSRRGKCFGFFLQCNPENSESNWNCACSATLRIVSQKEGIKDITQTFSRSFCSNGSGYGYPNFTTFEHLMEPNNGWYDAKNDTVILEADVIADAPQRVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA14</accession>
    <name>A0A914HA14_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HA14"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14647.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14647.t2"/>
        <property type="gene ID" value="Gr19_v10_g14647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037203375" evidence="1">
        <location>
            <begin position="16"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14647.t2"/>
        </source>
    </evidence>
    <sequence length="282" mass="31511" checksum="A38D18E06FEDE352" modified="2023-02-22" version="1">MAIILSTLFISLALANTIVECNAKLIVYPQTSFNKDGPIAATNKLPPKAALVRKLDEAKKGFSDAAKMADQLQNMLMATNPLSGGIHSKSGRPNHLRSDSENPFIDYWAADWKKCLCSGASETIQIGIKSSYSLGLSTIHHMCNQLTDKAPLTKDECRTFNTQVFTSTMNITAELTSRDVLCELVVGQCDQPSVPMKKDRPFSCTFCMTLHRKAHIMTENFSKLLTSFSLMCTRITNEPDEKKYCDEYVKTMAKHFSDILTDHFADARADYHCHKMFKCTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAF9</accession>
    <name>A0A914HAF9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HAF9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14763.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14763.t1"/>
        <property type="gene ID" value="Gr19_v10_g14763"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="900"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14763.t1"/>
        </source>
    </evidence>
    <sequence length="945" mass="100937" checksum="A1A6FEFFCEB2FD9D" modified="2023-02-22" version="1">MDDGRVNSVGGGDDDDNVTAAVSAHANSVQSTHGALVAAGALRKDGVTELDAAPPKPQRALATTTSSCSMECSVLLTIQFFERLSFYTMKGILLPLFVGTLHVNEASAKAFILLCIGVTVLAPIVGAAMADAKNGNYGVLASMFPLYFAGQLLFTVGPNIPGLPFLHPGLEMFALFFLVYMCGGIRAVLAAYGADQIVPPNAAQIGRFFAFYYAAEQCAIILAVTVIIPKLQGVAPWPLPSDQPFLSVLIAGTALLLLAFATLVGTNRLFRKRVPSGQNVFSRCYGTIKTALHNKKRYKQRRLVLAKSRNQQISPPKNVLDHFLDDHNCERDKECDFGRKNVCGQVKFLEELRVVLRMMLLFVPLPLFWAYQSQMFSLWAVQKMNVDPSFPIIGVFLTPDQIGLLLNIFMLILIPVLYYLVYPSSLAQLLSVNTYLKRMASGIFLCALACAMSASVQFWLNKSVSPPLQPPPNGALLKVFNIFPYDCAISVVRAGDNGTGTGMDISIAGNGSSNDAPFTLTSGEVSNGYTDLFFKFGAGSSCAGHRKSKIRMEIKVGKLHYAIVSPQGIMSSAMDVLKPFPAAGQSSIGVVVMMPCNSLDQQLLPAECANATLNMLAQALTPFASPFAICPFAPSSDDDVTASAANSTESSTNSSATSSSTLSTPSDANNASSSSSACIMWDFGDIQSGQLSVFPPRGDNLGPGSASIYALKTVPGGVYTVPPQQSASSPDDDGSNSSSTTTTTASIWDSGIQLDGNGGVSLIVLSLDGSPLNGASPNDTSNSSQPVLTVLPIVGPNSFGALWLLPQYFLAALSEILLSITALEFCYIQAPIALKATMISYWFLMIYIGWSLVSLFARFQLSPDPMVQLLLAACSMSMAGALFAWLAHCCYTYKDRLGVTSSDDEPRRKSATAAQSEDSSGGLTEMFSHLRGSIARLPKRRVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAP7</accession>
    <name>A0A914HAP7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAP7"/>
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        <property type="gene ID" value="Gr19_v10_g14838"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14838.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8098" checksum="CA04801A877C6913" modified="2023-02-22" version="1">MNVTPQALLSIPATSVSSERLFSKAGLIYANTLRNRLSAEKVEEILQIKANLSEFPLKLQDYDDDEDFPGGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAR8</accession>
    <name>A0A914HAR8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAR8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15788.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15788.t1"/>
        <property type="gene ID" value="Gr19_v10_g15788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15788.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29318" checksum="587F0BDC9B6C0E34" modified="2023-02-22" version="1">MSRRSYLMRRPRDEDDSYDYGEQELIWAKPIDARLTQKLGPSYAGGKDFVRGSEQSQRQFYGDQTVMGSNSQQQNELGEGCSTVDRNIRLLSHDERNKISASIVKAELRGDLERVRKLKRKLEEGAVEEEKGADKKDEVGGRTREVLLLNMDKRSGLVTPVGTTQPKNQTESPDNWKSTVDAEFGKRMELSQMIAEEKTTTAEQQIAMFSRSAKVCSDSKVDDDWVVDDNIMSHPKKRRHADKESVKKARNMVNGESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB89</accession>
    <name>A0A914HB89_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HB89"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15507.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15507.t1"/>
        <property type="gene ID" value="Gr19_v10_g15507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000282">
        <property type="entry name" value="Zinc finger, matrin-type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15507.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29232" checksum="012662AF49FA6CCF" modified="2023-02-22" version="1">MGTEKNLEKIWASLSGRRACSFIIAAKTHVWCSNFYRKKYMASFTQKPPSSVKDHRRTWDRSEYAIKAQERVNVEREALDIKKGIKPAPKGPKVHREMLKPREFKVDLESKVGRQVVINKTTPSSETGGYYCNICDCVVKDSINFLDHINGKNHQRNLGFSMKVKKSTVDEVRERLSMKKAEKDSLSKEDGEERSRDLKEEEAKMADLKRMQRERQKESSRKRAAAAAPTADEEADAELMRVMGIGTFGTSKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBP7</accession>
    <name>A0A914HBP7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15631.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15631.t1"/>
        <property type="gene ID" value="Gr19_v10_g15631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="74"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="295"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15631.t1"/>
        </source>
    </evidence>
    <sequence length="623" mass="69786" checksum="A39E462D97F786DF" modified="2023-02-22" version="1">MGAVGLPPQLLLRFWHFVVPMLLLLFLFRPQRSAHNPFLLLLPAAARLDLLLLRCSSPARSSFAFCSVQCPNWPRREVAAEPGRAKALTDNRSAHIVTGSYFSQVFRLGFKLRLICKARGDPRPKIKWFKEGMEMQPKRNAHYYEKPLGKEEIWSKLEIDPATMGDQGIYACVANNQYGVMAKNFKAERERLSTAFLFYPQLFLLLIATNLDSSCALFSTEREFAVKSSRTVTRAWENSFLAFQQFPSAQSNSGSGIVHEDQSTHTYFCIDNTATTMAEELVTLENGTRVSGGRWTITKKLGAGAFGAVYLCQDDKGTQAALKTEPVVTPHPLLVMEAHVMRSLDNLRDGDGKHFCRCLDLGRDEQRDGKTGTMKSFNYIVMSLVGRGLDGVVRDAGGHFSPGTAIGVSIQMLSSLRAMHSIGYLHRDIKPGNSTIGRPEANELRLLYMIDFGMARKFLRDDGSHRRPRTNANFRGSPRYASISAHINREYCRKDDIESWFYVMIELYKGALPWANISDMKAIGDAKCLRLKKQPEAVRRQAIADLLAGCPKEFGQILKHIDEMKFSDTPDYDMIISTLRNCMTSNGFQEHPYDWEVGRRNTGQEQAAPRGGGGGGGGDSFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC54</accession>
    <name>A0A914HC54_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC54"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15704.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15704.t2"/>
        <property type="gene ID" value="Gr19_v10_g15704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15704.t2"/>
        </source>
    </evidence>
    <sequence length="782" mass="87276" checksum="13F1EF942906DF35" modified="2023-02-22" version="1">MDTTISNNVTAKVDFDELNSPEKDNTSRGIRNYDDDGIGEQPDRTDDMQFEADGELCCSSSLFPSDDQQLNMADEEIQSPLLRSIVDELLTQQPAKLDVLVSAAMNKKQNRQAVDGAEEASTVESRRLLADEHGLRPQSEPSLLMRAASSFCARPASVGAFQQPSFLIEKVADEIVCEDDIVEIAVEKDPETQTMRGHHCSLCKMPICGDAGEQEGFVCFNCKNKGPEIAANKQSVAAGDGEEDEDAPQLHDVDDAILVDRKRHRNNDATKKLEAIKWARRNSIKSAAKIFGVDRKSIQVWIKQEDKLKQQMNSGAGTRKRLDGGGRQVQHLDTDTSSHLVKFSRASSKADLLANGQAVSDQTNRQNCPQSHQSDENIAERCAFDPVTKRRFYEPHKRHGCAGEYCLSQVTQIGERICSVENKLARLSELFRQLIQQNGKTGDDTSEKGKQRQRQQISSSASRLQDYIIRPPANALMAQRVRPLPTSQQHISRLPPAGLCAQIIKYPRLSSTAAMHQPSTVPHISPFLNSSANHNNQILRPTIYQPNRPLGHWKQPEAVVGKVLDYGIKIYSPENAMKGAVENGSVCPVCFAKFEPFVNLSIHILRHMDKKLPVDFIRCKLCFAQNSIHFLSVPAVREHIRTAHGVTKSDAIREIAVSDPKGAHPMVQTVLKRFARLRMVMWESHSQIKTKLALLVKQQQCSNSSSRKRRRNRDEGEEDVVDQLLFSSTGVPQSLSERFQRLRKMCRVLSDQLVVPICEKSIAGLDDVHIAELSKGFALSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HD82</accession>
    <name>A0A914HD82_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HD82"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16045.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16045.t1"/>
        <property type="gene ID" value="Gr19_v10_g16045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="33"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16045.t1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47896" checksum="D0DED5BB0BC0413E" modified="2023-02-22" version="1">MPPFYPELKRASLRQLAPSSWEGCFPKDQLTEANRLRFLSRMAYIAVAHYLLYRGLIPKGVFKRRKIEDVAIYCFDSNKRWGHKLSEMMKGIKEAIEKKYVKQSFIMINEDSDNPNVATEVFSISFCYMEEHALSVLDDRGNSIISFGYKGEKSFRMQVKHIIKKLSAVTKHLKPLEGVTPYLKLTYYENTPDDYEPTAFKPCEGTYTFKTPPTFYNFGHTSSNETAMSFVLESVYFTEAEVADLDDLLLEQAGYKDNDVINPMDVTADGNFTSEEQQSPKIAESKQKTQSFVESDRSSGGLQVTIVTTSPVEATHSSETIEKARQDKDEMVLSVPQYGSPENGTLDADESDDIDELMQVSKKVRESPYVKTRQRARMLTPRGVEFTRRASKRVTKSSASNRFVLMSPNDDSQYNINSPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDE4</accession>
    <name>A0A914HDE4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDE4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15998.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15998.t1"/>
        <property type="gene ID" value="Gr19_v10_g15998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037294935" evidence="2">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="125"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15998.t1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42922" checksum="A63E39950D088A3E" modified="2023-02-22" version="1">MFGATHVSCLSLLVMFGGAHVRYQTMFRRAFPFLQCSAHHACSTKALSEQTGRHCMNEDPTWLYFLLIRLLASLLAKIPSLRSTAIVRTFAAQLHAQFGFSKTFRLYLNITMDTTLSKGMSIADLIVLKKLGAGSYGDVYLCASAAGMEFAVKVEKMGTNELDKEQTIYEQLAQRRPLNFCEYFGYGVSVVQFLSGASFQLKYLKITVVGPTLDKFLDNYSYSRKFSPGTSISVSIQILNGLQDLDDIGFVHGDLKFANVAIGLKNAQRRIFLLDFGHSQSTSMYSRKNDTTPWFYMLLHMYGGPLGQKTKEEALRSCPSEFSRIHELIEAQQPHQRPQYETIKEQLYGCLCRLRIQEFPYDWEEGATRWALLPSSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEA4</accession>
    <name>A0A914HEA4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase subunit 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEA4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16712.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16712.t1"/>
        <property type="gene ID" value="Gr19_v10_g16712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16712.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17236" checksum="F4FC77430418BDA6" modified="2023-02-22" version="1">MGKVGQSMLVAGDIISQPNFVGVLLLLGAVVAIVFTKCCWRSVTAWCCCCDCFHQMLLSFCYCLLLLFRLFSSNVVGVLLLLAAAVSVVFAKCCWRSVTACCCCCGCFCQMLLAFCYCLLLLLLMRLFPLTVRPSLLGGVHFFAHQSVHSIPFTFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HES1</accession>
    <name>A0A914HES1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Delta-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HES1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16470.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16470.t1"/>
        <property type="gene ID" value="Gr19_v10_g16470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000063">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="397"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16470.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="56496" checksum="1AAB1A49AB31841B" modified="2023-02-22" version="1">MKFPTIAFASPFSKKICAIHQSSTRNLFVHYSLPTFSGADENVQFSCSQQTFGKAKTDLNVSEFSFNFPSWNSETRGAEGDNSDDGFCTLNFRLCVDAVDHLSTVGTFPARKFCNVLFATFAVNVRSVRPFDAADRTFVVDAPSGVVHQQRFDFTSPILPNVSVQLDILSNSHKLLLASSFLTPLPTHNSPISPVFSFVNYGNIFKYRLKATCSAGFVGPKCTETCEPPKSGDHYFCAVDGMRCMPGWGGTRCLRPQCLQKCSNKGRCLQPGICECAPGWGGDECDQCVTSRGCKHGNCLEDQPGSCTCLPNWTGDNCDVLVNKCFQRPCKNEGKCTTDGVSGDFFRCICPPGFTGRDCGIPPIGDKVSDLERTVRDSESFLNVEFGADNAWEPLKGHCTELTTTDYVYSLCMFDRTIQKVRNGHTETSLGQWGKWAGPMDGNKFKAQRYEHGQTCLNGPERWSTFVQFECGEELQLVDVSEPSKCEYHFLAKSPTACANAEELKGEHGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFD3</accession>
    <name>A0A914HFD3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFD3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16465.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16465.t1"/>
        <property type="gene ID" value="Gr19_v10_g16465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16465.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18434" checksum="A98747F5CB28631A" modified="2023-02-22" version="1">MMQFNPNRFTSFPELLKFTTLLTTVLVMLSLGSAAIEPPGTTFVWITAVLALIVDCLCILALGFELEGALFKPDSTLGWPLIECVFSSFFAINYFISIWLCVNSKVFAIFNSSTAYSLAATFCLVAFVQYALNVIFYARIWSTEQRRQSNEINPSQLGYTNYGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFN6</accession>
    <name>A0A914HFN6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM135 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFN6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17089.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17089.t1"/>
        <property type="gene ID" value="Gr19_v10_g17089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="9">
        <location>
            <begin position="446"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="10">
        <location>
            <begin position="625"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17089.t1"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117731" checksum="55326483FF084581" modified="2023-02-22" version="1">MDNCAQFYGWQKALQPGIGRILRHDNATDTRVCAKKIAIVEQLRGEGDEVPDSSTDAVAHRHPQKGLDELVAQLGHYNENICRDAIHGVRLQFKDSSEQLRRHLRKIIPAIGSLINRELKLTATRNQLKRLIEMVCAVPSEVISSHFGLFCGYVLTGISDVRAPIRTLSFDVLTLLLQKYGRLCSQNRELFSAFLQLMGGQRKPENRTKLLDALSQFIVVFGVFNDNKLWPERTLTISFEKGMTETRSSASAVSLLPSAAYFHFPVLCLDSANSVDGTSPLMTRDGLLNCCRIFCPLLEAIIQVEKDADGTKFTSTMSRVHNVVSRLVDVSLHVLNLQFDGAGELRGQIVAIFGQLRRCPLTEFAIFHFYERIHLLFFPLESVVRMLLNKGAVGDGAAARERERRLREQLFRRSVATSRRSAFDRRSDTLRARGERTNEMLSTLVGRMGEQVEHSEQTTAALVHSSSVLRESHSNFTAVGNAIRSGGKLISKYGRRETTDKILIVLCLFLYFGVFRAAWTVLFPPINPHFTGTDQTGCSAPVHSVFSAGAVRPPSFLPVFCPLCPMLCPDWRPTLLDCVFCPPNAMSSVTRGIPTVSGPFETRSSPHAFFVSGRTARCTRCSLQLKALVDRRGRVDRVDWVRVLLNTVRSSVFLTATEILFLAWLCVFRRLLGFATWPTVSVLNAFFACLMSIWIESKARRGTLVPYLLNLASEAFFRQAQNRHWIRSDPPPFARAQSLLFGASVAISVAILSRKRPVGQKSARSAEFWRSVLHRAVGFADGEDENGEIVGKRKIHSNDPKRRLPSICGVGGRNCPDSHYNCAMKAFNLSLKNFSLSLAALTLLKLFSALRSVTKGPQKFLRPPFSTFSRSKNAKKLIEHFRVPTFVGVLPLLCQFSQCIFARLFPTKNASIARPIGFGLSAAFAMAFLWPNNNLALYAFWKMAEFAYFRLADAGIVPVYRSADALLFSVLSAYLLSLAVLEPHALRPNYYKFLCSLTGNRLQHFNRPLFDRFFGTSSSTVLHRDYRPEIMPQLRTINPAQYLSPLPINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH19</accession>
    <name>A0A914HH19_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosol aminopeptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HH19"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16877.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16877.t1"/>
        <property type="gene ID" value="Gr19_v10_g16877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10590">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041417">
        <property type="entry name" value="NPEPL1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF4">
        <property type="entry name" value="AMINOPEPTIDASE NPEPL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18295">
        <property type="entry name" value="Pdase_M17_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="348"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16877.t1"/>
        </source>
    </evidence>
    <sequence length="527" mass="56086" checksum="BDE085F89C29FE36" modified="2023-02-22" version="1">MATFKLRQGVDCEKKLEPAGETQVLLVGRQSSIKAAQNGTDWTKSVTEKLGPLVDGQVLKRALSKFEKSSGSMPLYMDLAKLSVVSEDLSRYNSPANGYGFSREVSCVKVAKGVKFLSIVLFTDYASAMASCVAIARCFPLFSLKSKKDNNNESLNVQVELVLVDGKTLSETEMNFLDTLCAAVRNCARLVEIPPNILHTEALLDEALSQIDAIGVPIEKTIIKGQELDERGFGGIYSVGKASKHPPIFACFSHQPQGATETIALVGKGIVYDTGGLTMKSRTTMPGMKVDMGGAAAMLMAFCSLVKANFKQNLHCLLCIAENSVSAEATRPDDVIKMLSGKTVEVNNTDAEGRLVLADGVFYAKDTLKAGTIIDMATLTGAQAYATGNYHAAILTNSEELELACVRAGRKSGDLVHPLPYAPELHFGDLSSKAADMKNANLGAQVGPPSALAGLFVGSHFLDLNKPQGVDGEPRWLHIDMAANVNSKMVGDRSSGFGTTLVCALLARHTDVGELAAAAASTSPTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HID6</accession>
    <name>A0A914HID6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HID6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17644.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17644.t2"/>
        <property type="gene ID" value="Gr19_v10_g17644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00777">
        <property type="entry name" value="AspRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047090">
        <property type="entry name" value="AspRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026673">
        <property type="entry name" value="SPEC3/Stum"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15795">
        <property type="entry name" value="Spec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="453"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17644.t2"/>
        </source>
    </evidence>
    <sequence length="780" mass="87153" checksum="39E78A98601303EA" modified="2023-02-22" version="1">MATNIIAGVSSVIGERQKGWKVVQKSLPRIVDYGRNEGILQIREYQRGNAVSNIPGIVIAAQEGLEAHQQAKENKGGDKVNLPTNDITLMHEAIPFLPFPIALVCLFLNVVLPGSGTILSGAAALCMGQPRVNIKEGRKLVTLLVNLLVGVSQFFTITFLFVGWFWSIAWGGLIIIHAMQYREALQQRRQEAVATAAIEALTKDSILHRRDVKTLVRQHKDKGKEDKERAKGAGENAPNANGMTGTQLSKDGGTATSMDATLQRDKPMSGVFGKSILFRTSFTFTYSILKTMLLSFWGFLRPGWKTHFALVGTVSCRAFNSFSLRTHNCGELRLHDVGSRVKLYGWLAYKRMNKFVVLRDSFGSVQAVLPRTFTSLIKSTNVESALCLEGVVADRGKERNAEMATGDIEIIVDRFEVLGPCDPVLPVQGSSNEHTRLSHRYFDLRSERMQRALRLRAKVISRLRRFLEDRCGFVDVQTPTLAHTTPGGAAEFPVPANKSGECFSLPQSPQIYKQLLMCGSVDRYYQVAICYRDEAAKSDRQPEFTQLDMELSFTSQEMILSLIEQLIVASWPDEIVPKPTVPFPRVSYREAMERFGTDKPDIGDKGMAHRFDFAWVLNFPLFTRNETTNCWESSHHPFTAPIPEHLEQLRQGKDLGQIEAQHYDLVLNGVEIGGGSIRIHNAELQRFVMEHILNLRTDELEHFLTALRYGAPPHGGFALGLDRFVALLNSGGETKCTIRDVMAFPKTSSGRCPMTNSPTPPSKELLKRYGLNVDAEQQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIL3</accession>
    <name>A0A914HIL3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIL3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16973.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16973.t1"/>
        <property type="gene ID" value="Gr19_v10_g16973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8206" evidence="1">
        <location>
            <begin position="429"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16973.t1"/>
        </source>
    </evidence>
    <sequence length="747" mass="84400" checksum="F5F54287F78CB52D" modified="2023-02-22" version="1">MRNKRWLAKLLKIENSQLTDGTEPATGQTLLNCALPCPLSKALEGKCPNGDFLWGCDDCGKTLAFVKQANAQIDHLFCACGRTPVEAFSFRCANVEEHGDIFRHFASKTALTDQLVRLHKKEDLNILLMGETGIGKSTMINALLNYLKYPTMHEALEADDVAFMIPARFNKTERNVDGSYVSKSVFLGEANAKERLDATKSRTQCATPYILPLKEGNKLCCVDSPGIGDTGGILNDQINFPNMMYSINGLEKLHGIGFCLRPAAYRASVNFKYCFDGILTHMHKRNVLSLLEEELKPLEQKYGVELLHRNKFYCVDNEAFEKLCLIKKSGKEYSKKDMENYAESWAKSEAECHRLLDYLSELPPHLTRESVSLTDARRIVTDLAQPMANIMSRIQMNLVDINKLDSAIGKGEKEKDEVLKYYSVEEVDLEYPRLVCTDADCTTVKRTSDGGSTTVFTQSCHDRCWLEGVQEGSHPNPNIKNRYPMDSNNNCQKCRHSWMMHMRIHCEQRVIERTVDQALLKQIAQNRGSLSDKQVVQRQMEKEINTICEDAATLNAYQSSSALKANNDNTEAYIELSIKQAEQLMAESKGSSDFEGNRRKLEAHQELLRLYKVMKNQKSVSGGAQITPNDVPKIVGKLCALPLFGEDIKQMYDAHQLAQQKQQKRFKDEMVYGGKNQKAKPSRNRYESNQQEAVTFDYCKQKIAKGMKRFGTSLFGSTAQQQSNAQTYGHCAFRQEIVADSWAGNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIY8</accession>
    <name>A0A914HIY8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-2-macroglobulin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g17326.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17326.t2"/>
        <property type="gene ID" value="Gr19_v10_g17326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="4">
        <location>
            <begin position="233"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1160"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1161"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1187"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17326.t2"/>
        </source>
    </evidence>
    <sequence length="1437" mass="160966" checksum="AFA7DB64EA87959C" modified="2023-02-22" version="1">MGFWIVRGRSIQYSIGLSSPNVTVGAPLDVNLRALPNSLALLHAYDSRLEGLLSNTGDSSRTVHLWSFSEFLSPDPPGEQSAESFAWFSNLIELATILAKRKEVCRLAGKLNPQCPLVVTQKGSSPPLLKTSSSRLSDDCLREMEEECERQKSGKERADTLTEMQPREGNAPQMPIKMAGNVHWLVQRPSLKTTPSGMEDVQSLRSAKRTGDEHPEKEKAGEELSLRDFFPEVWLFNDYRIENGSLAVKLNSTPHSVTAWNFVATFWSLGRSDVCKAEKQSLVAKKHVFMDVDVPLHVYVNESVNVHIAVSVVNLTRNEHMSVCFRGLSPKVCGDVGRDGSFGETDFTRVVLTPENPMQLKNFFVRFLRPGTHNLSFELRSEDVLKGHDWHCRGKVSTVFDRISKKIQVERRVDVEEHFRQIVVYRRKRLDEGEEQQITLEQILDSTSATTSTARTSLLASAPDVISYSMQQQQSSSSDRSDQQRSLADLLQTKVSINAGGRKVYNLGVEFSKFVPSFPPALSTELLSVASPLDPRGNAPMHRVRNRPVLNAFSEEESSERNLRSSGKESTKAKERQKRRRMAESSERPLQGYSLPNLLKELAFLTYELKSVRTMLTVGAGAGDGEGRDESAAEAKDGTDREWTEQRELLLGTLLSELLTFSDCEHRHKDCGFGEFGRPKEPTERNLVLTTLATSLLCEQRAAEEYVRFILSFLNFRFCLFLICGPIAFLAREARTLLNGTDSGGKGSAGSETDFGGMGMDAFFNDPSEQRLFLESLFVQAVMDCSAYACAASPLAKESWKQLHSSFYRSVDLNKRYDIRVIAALAYMSIMRSRLATATLRDDTAPFWGPVEDFEEKGTAHGVLERSVQKSSTVLTNALALLAYTREHSVYRYWKNEFDFDALSNWLVEQQDSRRQYENALDSFFASRALFQFVSANAARQARQALLGSLQGNFSIASSPSLSRQFNADELPFSLSVSPSASTMEIETKGEAKLLLGVRVLMEKRRRSRRDPNDVEPVTLSLAQSRTHPNFVLQTVTIISHSQLIRAVQIEHGLFTGFTSRPHLVQILNSSVQFQAGPRVSLSAVHFVLSNLIKEEAIVYTVTLIEPENPYAPTDLAPIAITANHHHLTLGQLIVLPDNLDFGPAIEGVGSLDSLLERVPRPRLRRSKKHRRSKGRHQTEDADKDGQQFSSSGRPPTQSFLTQLDAFYPRTLPTSQLRPPFMQMMVLDRSRQPSPDIIETVCLRNGVCTCAETTCTLRCSSCARLTFREICQNIYSSDGQLQKFALTFRLNPNSVVHTVKIAHSTAEYTVLDNVRVVEWRSSWADQPELLTIWIRKCNIGCLNVLKETSGKSPRFMLIGNPQGLFDEGDLSTDWEEENGDVAGGEVLAIRAKDRMVRTHYVMYDSDRLLKSTDCHELFGRVADESCSTESGKTATDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ26</accession>
    <name>A0A914HJ26_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HJ26"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17349.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17349.t1"/>
        <property type="gene ID" value="Gr19_v10_g17349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="201"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="650"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17349.t1"/>
        </source>
    </evidence>
    <sequence length="846" mass="96486" checksum="702829F4BD2A2181" modified="2023-02-22" version="1">MYHLTNTNTSQYIQVHHRTFAQIKWLRVRIDLATPFGFAMNVRLLSLRSRPLLFLLCSFFGAGSEWLSDEEAKPFPSPSSSNGTFYEGNSVVSGNDQNAFHPKQRAKGVREEEYRLEAKNVTIFIPELHFSSQNGVIELNSFNITADFLEVKSGDQTDLSRKIQSLLLMENEPTSATNTTADLNTFEYPELVASLNKSLNPCDNFYNFVCDGWMKSNPIDEDKTSANQFQLINNLIEDRVKEILDDREHFHALPPYDQMMFDMFDACMDNASRLAAGSGTLLRTLKSLKQSFGMRYITDWLLKVWPINLFYVVNVGPDMRNTSNTILTISPNNVFLLSEKLYIEDNLAPKYLAALKRYLRDLLELLYTDDVRQSVFKKANKAADIERRVNAFIEVEVRMALIINDTDKHYDNAYNDDIYTTLQELQHTLAGTINWPRYLRRILPDEVLIRKFSNAIGTVEARISEVELIRKFEKLARNLSGQMLSDYMDWKVILAEIVHLDSRYMEAQFELDRVLQGSLARPAQWKECKNVVLGFFPALIERVEATKGQMGEMFGNVKKSFHQMLDANSWMDVKTKSEAFEKLKRLNVLVGYMDAIFNETKLRKHFKEYDVHKGQSFPEMAFALSKLMNRKSFLQLLEPVEVEFSSLVINGFYYPIKNSIVLTGGILQGVFFNSNRSITMNYGSIGVVLAHEITHGFDNNGRLHDQSGNQKKCLIDQYNAIQVPGVEGLHINGNLTQGENIADNGGMRAAYAAMEANLANNPKMAARRVRGLEQFSPEQLFFINYAFSWCTNQRHEAAVFASVFDSHSPPESRVNVVLGNLPQFANLFKCPLGSAMNMGSRSCSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJE8</accession>
    <name>A0A914HJE8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM242 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HJE8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2021.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2021.t1"/>
        <property type="gene ID" value="Gr19_v10_g2021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009792">
        <property type="entry name" value="TMEM242"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2021.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14504" checksum="51278E2E3839AF24" modified="2023-02-22" version="1">MHHNEDERSTTKWIKISCGLSSAVCFCLGLRAARAQAAPWRPGELSRRSLLSGTGLAMQAFGIATVLSVSGYILLLVAVSGVLGVNTWKQFGQKMTNFFGDRLRIPKGTSTEGGVSSFTELLEMASQDPIAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK11</accession>
    <name>A0A914HK11_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Dystrophin</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g17329.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17329.t1"/>
        <property type="gene ID" value="Gr19_v10_g17329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16242">
        <property type="entry name" value="EFh_DMD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056503">
        <property type="entry name" value="Spectrin_Dys-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL63</accession>
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        <name type="scientific">Globodera rostochiensis</name>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <name>Zn(2+)</name>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN48</accession>
    <name>A0A914HN48_GLORO</name>
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        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="Gr19_v10_g3033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="41"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="387"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3033.t1"/>
        </source>
    </evidence>
    <sequence length="587" mass="66745" checksum="49ED7CD50281525B" modified="2023-02-22" version="1">MSNDALNNESQIRRRRLPLELQCELIYALPLERASRLLLLSNGINTNCSDRVRKLHEKWQNRWDSTACHEDLALSEPDRLIVQHNGKDYVWGSVMAEKAISKNPYGISYFEVKILKEPGLILIGLATKQMPLNSLVGLHNGTFAYGNWGEFLGHEVEGCGHLSNGRPFIVGIPQFGVGDVVGCGVNLKNGPIIYTKNGRRLEYLWPTFYNLERPEELRLLRAKIAQLESQQTINAGFILAAQRKRRRIEGGHEDTTEFLGKKFEQMEEKVVKLEFENKVLRAELAHQKLLIAHMALQTKLEQYQNKHHQKTIDELTEKLKVSIEQLSLKQQEHEKLSNAHTKQMEEIKEQREKDVTELEEQKLSNANKFAEIEQKNDKLEKYQKEQQLNIIDLQKTVAVLREIGLINRWNSATCHDRLALIGPDRLVVQRNGEANWVWGSVIAENPLRPLNPYFEVKIVEAKGNILIGLATKQMPLDKYVGKHEGTYGYSSDGNFWGYEFEGCLHAIDGRPLIEGKPSFGVGDVVGCGVNLNNGKIIYTKNGQRLDTANLIVSFAVDLFPCISLARPDTKIEANFGPNFQFNISDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN75</accession>
    <name>A0A914HN75_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HN75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2323.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2323.t1"/>
        <property type="gene ID" value="Gr19_v10_g2323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2323.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17369" checksum="334BBD80B8B9C677" modified="2023-02-22" version="1">MLAYTNTDKKPSEVNEEPFLFEQNAVQMAKFELEEHGAGKWMMFFDKQRELDNKWDEAKRLYNAGRLEGINSMKVSTAYDNPRAGGKKNGVIIFYCGPHWDKAKMMRIGHELLAQMPYNFHFAYKADWQTLEGTRATGNRKNHLYVINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNJ6</accession>
    <name>A0A914HNJ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Steroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HNJ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2241.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2241.t1"/>
        <property type="gene ID" value="Gr19_v10_g2241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2241.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35500" checksum="015A396EBB8535D5" modified="2023-02-22" version="1">MELIYAILSIFGLIFLLCLLFKVLRAFYRCIYPYFIARQKDLRKLVGAQWAVVTGASDGIGKEYAKQLAIKGFNIVLISRSADKLRVVKEEIQPKQFLQPEVRWISFDFTNANIDDYEKWLFPELAKLDIGMLVNNVGAVHPVKRFHEIPGGKRKMANDLILNTMPHTILSAFVLKQMAERKKGIIINISSFIANYPFVYCSVYSSVKKYLSWFSTILRKEYSDTSIIIQTITPGVVYTKMSQEIVNNEKPNFFAPSPQKFVASALRTVGHVDEASGCFAHQLQNESVKMMPNWLLEIASRQQIKKLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNP9</accession>
    <name>A0A914HNP9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HNP9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2827.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2827.t1"/>
        <property type="gene ID" value="Gr19_v10_g2827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08028">
        <property type="entry name" value="LARP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF166">
        <property type="entry name" value="LUPUS LA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08777">
        <property type="entry name" value="RRM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="114"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="XRRM" evidence="8">
        <location>
            <begin position="227"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2827.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48133" checksum="73835C71C6DFB331" modified="2023-02-22" version="1">MTANGVAQATVIKAEQGMDEKIMKQVEFYFGDINLPRDKFLQEEMKKDDGWVPLTTMLKFNRLAALTTDLDQITSALKDSHLIDVSEDSAKIRRSPEEPLPENTLEYWQEIKRRTVYLKGFPQDINLDEIAEVVEKYGEVKNILMRKTKAGKETPKVFKGSVFVTFVDQEQAKRFAAVKDLKFKGEHELVNKMQEDYWADKHVERRQQRELKKQMRKETIEQQNKSHYVKGQVLKLSGLPTGSGETKKEVSVHKLKEFFEPYGQPAYALIEGPEATLRFGGSEENAAQVAWQKAVAAAKDGKVIMDDSEITAVLLEGEQEAQYWTEFSKSKVEKQQRGKQGKTKGRNEKREQQQQTRRNRKRGAADNEQKQDLDGKKSKRTVFKDEEDDQKEEEAEEGKGPNGRVDGEAPVEKVVKEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ99</accession>
    <name>A0A914HQ99_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ99"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3657.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3657.t1"/>
        <property type="gene ID" value="Gr19_v10_g3657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3657.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7480" checksum="8851526E09ADCB8A" modified="2023-02-22" version="1">MVQPFPSISEVLRRNGRPDLIDYLTNCCRSKNSTIIEHAGKMFSDQGLGYITDAVKQCVNCCNARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQB7</accession>
    <name>A0A914HQB7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQB7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g326.t1">
        <property type="protein sequence ID" value="Gr19_v10_g326.t1"/>
        <property type="gene ID" value="Gr19_v10_g326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g326.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29518" checksum="16777D22484F3F61" modified="2023-02-22" version="1">MLGKPEHTVWIIWDAHKAFKLFLVPLRSAWVMSCAYAPSGSYVACGGLDNLCSVYSLHNVEGSASLRRELDGHDGFVSCCRFIDNTQIVTTSGDRTCILWDIENGRALQKFTGHTAGVMCLSLLLDSPTFVSGACDNSAKLWDPRDGQCKHTFAGNSSDINAVALFPNGHAFVTGADDGTSKLFDLRAEKGELATYGQRKLNSGVTSLAFSKSGRLLFAGYDDFNCVIWDSMRVEKADVVSGHDNRISCLGVPNDGTALCTGSWDSLLKVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQR6</accession>
    <name>A0A914HQR6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQR6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3580.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3580.t1"/>
        <property type="gene ID" value="Gr19_v10_g3580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3580.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31886" checksum="8A278B92EED887F0" modified="2023-02-22" version="1">MFRHSRFFNLIITLAVIVFALPIYNVHGFRCKRALKDESKAETEIFGVWCTEETYHRQCYLLNCSTGYQTRTEWGCASDAKALQKCTGSVFETDGFKCQCLVGKEGEEMSNEHMDSPVPVTTSTTTTTTTTTTTTTTTTSTTTTVLTTPTTTVPPHICKRAIESAEENEDFGQNCPAGDNFCYIFNCTSGTMPNKTVIEWGCTNNFNAQICEQNLVKFGFNRANDSCFCHIGYENENATFLLKKMHFDEETSFAFARHATSKFERLIIAILFVCVTSAVAHAQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRB3</accession>
    <name>A0A914HRB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3740.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3740.t1"/>
        <property type="gene ID" value="Gr19_v10_g3740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF135">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3740.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18658" checksum="3C7C1F5E7E4A7A3E" modified="2023-02-22" version="1">MFKISMPDLIEFNVGGQIFMSTYETIGYDKKSLLYAWYLERKGFAHLLLDKKGRFFIDRDPASFSIILNYLRLHSAKQLWEVCLPKDPDRLALLTQEAEFFRLPALRDQAVALLRKCTAAEEANQQQQMRGRTGCWRNGMNERKEEEEDDDEDEQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRE7</accession>
    <name>A0A914HRE7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRE7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3955.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3955.t1"/>
        <property type="gene ID" value="Gr19_v10_g3955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3955.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15173" checksum="2C058D25FCADBD19" modified="2023-02-22" version="1">MTIYNWKQKLDKTTPKHMHSQNEQKELMKLYYEIKDKNRKINDKEIVKMLNIGIATLLFFIYTSDHGTRGLGQFGATSSAPLPLSFDCLFRAGKLTRSNFSSDNKNLDGQSNTVIPWGKKGKGNDGTTMQKGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS96</accession>
    <name>A0A914HS96_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HS96"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4.t1"/>
        <property type="gene ID" value="Gr19_v10_g4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34071" checksum="0037B655B99FDC73" modified="2023-02-22" version="1">MTDPNEHKAKMLMEEAEKKLKKSGGLFSFLTGGSGGPSDAAELFIKAANVFKLSKNWNSAGGAFLKAAQVYDRGDSKHDAAMNFGEAGNCFRKVDLQKSVDCFQKSADVYLDMGRFNMAAKAHTTIAELYEEQKCKEKAVDQYQKAADMYKGEEQRSSAAKCLIKVAHYAADLEQYQRAQLTFEEVAIYEADNPMLKYSAKTHFFQAIMCSLCIDLLDSQRAIKRYEELSGQFAESRENQLCKQLMQAMEMGDPDGFTEAVQQFDKVSRLDQWHVAMLVKVKRRCGDGGEVKNDEEGEEDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSX5</accession>
    <name>A0A914HSX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3471.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3471.t2"/>
        <property type="gene ID" value="Gr19_v10_g3471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3471.t2"/>
        </source>
    </evidence>
    <sequence length="329" mass="36965" checksum="3998E59FCDD29D42" modified="2023-02-22" version="1">MDNIFKYDVEEQRIIRNVKPWKLDPHCFKEVKISALARRVDENTLIVMDSLRAMKVQLAVEPVQMCRIFAKIDADGLQIDDAFGHQRILLGQTFDRSQFNEGHTAQAHARVIRLKRDEAVSLLFNAFERTSSKDCVPCGLQPKKMVTLMERAVVKFKPVNAHHEHQIVCLADCQPPNSTDYMRMTIAQIQRVSQPKKMVTLMERAVVKFKPVNAHHEHQHLRLADLSRFNSNAAGGCVGGKQRTNAPTATGASGAVLVRGSAAHFSFHFVCEEPPEPSWLGEVPHIFHFISLCLRGASGAVLVRGSAAHFSFHFVCEEPPEPSWSDEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT41</accession>
    <name>A0A914HT41_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT41"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3971.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3971.t1"/>
        <property type="gene ID" value="Gr19_v10_g3971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3971.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9208" checksum="486C470B8281CAA2" modified="2023-02-22" version="1">MPFTKSTGRTPNLDKLNPIQVISLEKLNPIQLISLDKLNPIQVISLEKLNPIQLISLDNLNLIQLIRILLSQNGKMNLAKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT57</accession>
    <name>A0A914HT57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT57"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3527.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3527.t1"/>
        <property type="gene ID" value="Gr19_v10_g3527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3527.t1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60942" checksum="E9BD5314B05074B3" modified="2023-02-22" version="1">MTGEFDVCNAGTEFFICAMCNFDVELGADFWILTDNAEQEENCFYNMRRQLAETNLPWRLPVTLVDMFGAQAAPAGLVQPPAAKLARQGLHGSNALLRCRSGPNCYVKLRSQETFLMLNNYTGSTRHREDEHYRSHCGIRDCSYKRPALSKRKAVAVDCISQRSEPLFLIVTATNSAADHVAQHCRARKFDQLFQQSYRRQLETSGSELRCYDNGACLARLCPHVILFEEASMANCFEFFGITCRFNSNEMRLTVMNRLGALCHQKAREEMPHDTPTTARVTTILRKELEEDDCWEEDRLGKIVEEKSAQKLRYQEPGVVHSTRASTEAFLARRLVNKLLDADVSPKNIAIITPYKTQLHELYKVFSLLFKEPLSACIPLKDGKNKFEEPVSRPNKDSVSTSLAIPVWPETRATCAPNADLARFLKMRWPSTQCVSMTLDEGELLRWEGSARRSLQPGEPESRGEEERCARVRQVVQSTLEANVGLRAIRNCVQPWSRCANCKCQTATAYGGRRSEIGSTNLRFAPKKPKTDKCRKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTP8</accession>
    <name>A0A914HTP8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HTP8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3876.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3876.t1"/>
        <property type="gene ID" value="Gr19_v10_g3876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14350">
        <property type="entry name" value="UBA_DCNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF32">
        <property type="entry name" value="DCN1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="63"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3876.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31041" checksum="BE98595997F532DA" modified="2023-02-22" version="1">MSELKQEEKDKVQQFVSFTQSNEYAAIECLTNVYWNLEMACDLFFANSAAYMDQTPTAQQQGGDNQKIDKFFAKYANDPKDKEQKVESDRIGPNGMVRLLHDLDIAPTSRSAMVLAWKMKAEKPCEFTQKEFRDGLTALKPIGTLDAKSFRSALIKAEQETLADPQKFSDLYQFVFNYVNLGNESSLELETAVACWEVLLEDIGDVRGGIWVDFLRARKVKDISWETWNLLLKFLNEIDFDMGNYDVDGDYPEIFDQFVEWCQDSSLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU38</accession>
    <name>A0A914HU38_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU38"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3998.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3998.t1"/>
        <property type="gene ID" value="Gr19_v10_g3998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3998.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13737" checksum="AC56B8F50392B1BD" modified="2023-02-22" version="1">MGNSVGRFVEIGSNVDHAERTTKCAEGMGADDFLKFRNLEVRIPGLKVPIFSYKISELGIAASSKNFGSQNSEFRIVKKFWKSEVRIPKIGIPPSTGVPERFYNAQHQRRVKEHGQLKSTGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWL5</accession>
    <name>A0A914HWL5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWL5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5332.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5332.t1"/>
        <property type="gene ID" value="Gr19_v10_g5332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5332.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8463" checksum="D29CCD68736D0BED" modified="2023-02-22" version="1">MARAPKIGGTTNLSRICSPKLISLSGQWTAIGISGRWPDEIREVRGQWPKRQRPRNGTWPSETPEGLFAMEWANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXA4</accession>
    <name>A0A914HXA4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXA4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4992.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4992.t1"/>
        <property type="gene ID" value="Gr19_v10_g4992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF6">
        <property type="entry name" value="TPM_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036873679" evidence="2">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4992.t1"/>
        </source>
    </evidence>
    <sequence length="318" mass="34715" checksum="25A5220BC8F5945C" modified="2023-02-22" version="1">MRIQSEISLSLFFYAFFVLNVDGQNPAFASEFFPSSPGLLLPAAPTDPQKPKKTPTEEELIGKLLKSGAGLPPGPPADVPTEGENAGKKANSGEGQENIQHELEQSVQSPAAPPLPAKPENVDGQQKSERSVQVVAAESPSMPSGAVGVVGSPSAPPTYVQCLLRIGPKVCDPENILNAEQKQQIDQTLTELKVATRKENAKDECDKSGLEAMFIIVKHSNLLDEQTSEVQKTLNQAMDMWVHDHPCEKPVVILLSTDPSVFNRKVWTGRHWDVPVDPGQLVQLFMDQGSLTLQQKYSLVIMNMIEGLLERYEKSIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXQ6</accession>
    <name>A0A914HXQ6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cytidine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HXQ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4748.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4748.t2"/>
        <property type="gene ID" value="Gr19_v10_g4748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="317"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="38"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4748.t2"/>
        </source>
    </evidence>
    <sequence length="493" mass="55684" checksum="21543E3F765899C9" modified="2023-02-22" version="1">MLIEQAEMAQQNAYSPYSKFRVGAALLNKDGQFFRGANVENASYGATICAERSALCSAIGAIGSAKFCPMAICVVTDLNEPGAPCGICRQTLVEFGDMLVLLYSRPTKKLRRRSEDQLKSGGVVVIMNLMITLLLNIVHALLQLFLFVVTGGRRNILKVQRQHLADEKRSEMGDQQQQQQQQQQKASELYNKFSVLGEHRLSVNFPQQPNTNTYYSNPQYSVHTRDWGIHFLLETDLDANPVTAEVTFWQWYRSKQIHILQKSVKVFPQSGAHLQLQCNAGSNSAPSDGFFNVLIRLLEKKEQKIVENPCPPCDVDDEFVLKVGLEQFTVSKHYLMSVSPVFHKMFSVDMLERAQGEVNLEETNAEEFSAFLEAISPKLAHPNPSTVMGLLKLADRFQVDSLRNRCEVHLINCVEMSLIERLLCSEVYRLEKLKNYILKSLSGVGMREFYEENQAALNLLSKDLLIQLTVRICASFKIDRSALCNNCAKNLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY48</accession>
    <name>A0A914HY48_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H2 subunit B wHTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY48"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g511.t1">
        <property type="protein sequence ID" value="Gr19_v10_g511.t1"/>
        <property type="gene ID" value="Gr19_v10_g511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g511.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40694" checksum="620D6804335C8512" modified="2023-02-22" version="1">MFFVLNSLCQVRRKNRHLPKSSSPGRYSCSSKAQNKRRVNNVEEMEAEELSEDKMRQKSTAIEEELEDLVSLCGSVATTAGGDSLLDLGLDQDSIAVDQHQSDREFERKFFVMKEGSLSGKIYPLPHPASSERALYLLNENGELFELLQLDHGKRSFFYGDSVIGDGSVLMFFPVHPLFLVIEQLQRKASDRFLTAFDILEDEDFPALKELALSVKLLDTLKTVADCANDLTTNHESVKFRFNEGRLFEWLEERFRILKSSLAANDDENENCANDEHCFGILADYLPGSVSQRLKERLDIKSDRKGDVQQRKKRLLVEAAKEKETKIGCTPSKKKNTKLLAEASKGSRPIASFFGTPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY49</accession>
    <name>A0A914HY49_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GP-PDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY49"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5187.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5187.t1"/>
        <property type="gene ID" value="Gr19_v10_g5187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5187.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22372" checksum="5F3AB86BB43AE950" modified="2023-02-22" version="1">MFIYFRNPPAPADNVSNFFHGFRLGGHRGSPLNAPENTMVSFKQALREGVDLVEFDIGLTRDGVPVLMHDDTLDRTTNMSGLLRDHDFSELAAECNCAASFRRPRGVDLPDEPQPDGRVPICTLEDVVQWAKEKNVKMLFDVKDSDTELVDKIGEVFEQYDLFDCALVCSFYPWVIYRIKRQNNRILTGVTWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ00</accession>
    <name>A0A914HZ00_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZ00"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5976.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5976.t1"/>
        <property type="gene ID" value="Gr19_v10_g5976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="84"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5976.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25019" checksum="991BD6A67299739D" modified="2023-02-22" version="1">MIAPKSDSLVGRMKLSTSNGADVHFLVWDGDKKRHFAGIFLLLLDYPLTVCPSLADCPSLTDCPMTNWALTDSQYPYKAKGMIVLKIEKVSEYARDDVIDHRLSEAVYIRGLPWKISTTSDALFNRFGFYLRCNDENTDSNWSCAGTPTVRIVSQKEGKKDHTRVIFRSIFNSKEKRWGIEFFKMSFKVLMEPKNGWYDAKNDTVILSAEVTAEEPIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0M5</accession>
    <name>A0A914I0M5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">U6 snRNA-associated Sm-like protein LSm2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Protein G7b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">snRNP core Sm-like protein Sm-x5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914I0M5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5515.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5515.t1"/>
        <property type="gene ID" value="Gr19_v10_g5515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037823649" description="U6 snRNA-associated Sm-like protein LSm2" evidence="15">
        <location>
            <begin position="25"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="16">
        <location>
            <begin position="789"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5515.t1"/>
        </source>
    </evidence>
    <sequence length="892" mass="100487" checksum="47B76C9F67BD3AE7" modified="2023-02-22" version="1">MPKPSIFALIILFFVSFGIPSSLGRAIEPQNEVTVHGYIANKAYVEGHNIPFPADLVDVCPRNWKYLKAWINPMLADRIINRQACLLHMLSLHYDPATKVFSNQPNVNVTFLGDKPFGSVWPTACLLSSENTGWNFACRASTELNQDEAQFMPMVQHFEEKHGYERDVTLLAAPYDWRRTANMVEMDPYFANLTNLIEKSVNASGQKAFLVCHSMGNLIINYFLNRKVGKEWQQKYLNGTINVSAPWAGSLMLVEQILSGNADRLQFGGSLILPDSIVRNFIRTMPSSFAMLPSTLAFPPNQTLLTLAGVDYSTKNMDAFLALAGSAYMAPLYHELTATVDAQKYTPMFCVHSKTADGMPIFYNYTNGIAKRPKAKMGDGDALVNIESLRVCQKWMDEGKLVKKVVEIDGPTHMAILHEDKFYKAEIICGKGKNAKIKVAGRRQEIFADSYSARREDIFYSEPSQSQNISILRMSGAPRKSSDKIQIFNLCSSNFAVFDGVDRLLHEFRLLCHSIHRPKDEVGIDLPNLSVVLLPEQAQVLLENGFAQLKRFRNAGKGSADVIFTQKDNGEAAIKPSYRADNERIQSMARQIVIGRKIKAQKRKALSIDGLLSAKALKVRKLDRLQFAMEHTTEADQNENGCADDAGRVEECTPDELAEAMDELRQRELGKRQQKSEVVPSCSAQIYSDFLPQFPQNAVYGVRLAVFRDLWRKGFYLADGAKFGCDYLAYRKPPPEQHSEFMASQSDRRVQGEHSGQKANFVGHGQCGFASALLFGDELVERRRRSMMLFFSFFKSMVGREVIVELKNDLSICGTLHSVDQYLNMKVNDISVTDVDRHPHMISVKNCFIRGSVIRYVHLPTDGIDTALLQEASRKEILQSRQQQQQQQQQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I136</accession>
    <name>A0A914I136_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Guanylate cyclase</fullName>
            <ecNumber evidence="3 14">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 14"/>
    <dbReference type="AlphaFoldDB" id="A0A914I136"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g59.t1">
        <property type="protein sequence ID" value="Gr19_v10_g59.t1"/>
        <property type="gene ID" value="Gr19_v10_g59"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000023">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036696175" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="589"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="937"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g59.t1"/>
        </source>
    </evidence>
    <sequence length="1136" mass="126356" checksum="DCE31319C73D7E29" modified="2023-02-22" version="1">MKFFGISVLIFLVGFLLREYKCQNSAATTTTTLLTNATVGQIQIKVGLLFANGTQGMRTLFGFGQSAPAITLALNRANQEHLVDSLNFTFSWLMCDCFQPWAVGYATQLILQQNVDAIIGPPCVSSALVAGYDATFYNIPMFLWGPTVSSDLTNDTLYPTVLNTNVNSRLLSIAVRAVLAKYNWSEVSFVYTPDNQRMVCPYFQADFETLLNDDPNLSIVFKRKMDSSSESMRAALMALANRSRIVVACFDNVDDRRKFLLSITDLGLDGTTNSEFVFIIGSLRGLGMMQPGSSVGDNNKTAEYIPMWVQQNGLSNDGRDNDALLASRRIITVDLENQSNGQLDAFNRNMSAEFGKYPFYCGGKCMGGDGEQNPSNYARTLFDTTYAYFLALNNTMDSVGTNLGTLRNGTLLISMTKSMTFQGQTGTVVIDAYGNRQPTFYATMLDGTDTPTATINITIVQQQQQTNNTNGSAVPSSTTAFSTVTAIPLYTSDSAVWVNYGGKQPLTTPRCGYAGNECPQDISVYIYSGSGLILLLILATVAAIGIAIRAKLRERARLTRECLIPFAELRNLKELRSYEEINSEASKSMRSMHSSVSGSTKLTLGSNKKKLETECYAHFAYNREVVFGAKYPVKVRIGTEELGQLRKLRLVGNDNLNKFFGVCIDAPILYAIWKHCQRGSLKDLIAKEQYVGDTFVMVSLMRDLTNGLAALHQTFVGAHGMLSSENCLINDRWQVKISDFGLNMVRESQQMPRAKLLWTAPELLRQNNNRAGTVEGDVYSFSIICVELINRETVWNGTEREQDIDEILYRLKRSNNAIPYRPQIRPGDALRDQQSLVHLVRDCWAENAQERPKIERIRTILRQFNREGGSHSLMDYVFGMLEQYAGSLEQEVEERTKELVEEKRKSDILLCRMLPKQVADKLKLGESVEPESFQMATVLFSDVVSFTTLASKCTPLQVVNLLNNLYTTFDNIIDTFDTYKVETIGDGYLVCSGIPKRNGDHHAREIAELAFAFLRAVANFRIDHLHAERVNLRIGFHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGKSAQIHISDASNHFLTKLIGGYVTEPRGEVIIKGKGVMETFWLLGHAADGATDSSPMYRTFVNDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1D4</accession>
    <name>A0A914I1D4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1D4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5977.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5977.t1"/>
        <property type="gene ID" value="Gr19_v10_g5977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5977.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25973" checksum="D01590AACFAD1FE0" modified="2023-02-22" version="1">MCCNGCTDMWMCCCCCQVTKGAQAVAWICLDLAKLPIRKMGVFKDYVKSLIDIGLGPQRELEPQAAQLPAFDNPFKQKNAGASTSVSSYGSYGVDSVQRRRAVSEAAGIQRPWGLMAYHFGTVDEEDNDELEGEQNQQQQTVMENEEVEQYNAYRNQHSFSMKDAQKEATSRSPSSIVSICSSVLVVPKTPPDTSRQTLSTNGSIRSNGLEKFRTKASWIALAVPTSSSKNADLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2C5</accession>
    <name>A0A914I2C5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:56052"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28729"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="3.2.1.114"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914I2C5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6226.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6226.t2"/>
        <property type="gene ID" value="Gr19_v10_g6226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004572">
        <property type="term" value="F:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000010">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="11">
        <location>
            <begin position="532"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6226.t2"/>
        </source>
    </evidence>
    <sequence length="1189" mass="135444" checksum="C44290D2EC8DA79A" modified="2023-02-22" version="1">MALFFRHNVCWLVLLALGGTCMLISLMLFVLLESEMRHREGEDATSASTDCTASTSREQCEGSNDVLEPLWQQRQQNHSQLYNFRTDLICLAKDAMITRNASTDVQMLSLYDILPFDNTDGGVWKQGWPITYDQNKIREEKRLEVIVVPHSHTDPGWLTTFEGYFEEQTRHILDGMVQHLEDKPDLKFIYAEMSFFELWWSQQTAEVKKRVRKFLNTGQLEIVTGGWVMTDEANSHFFSTVMELFEGHEFLQNQLGHIPRHHWSIDPFGLSPTLSYVLNRANLTHMAVQRVHYAVKKHLARHRQLEFVWRQMFSTGDKSADFQQRHHSDDIVTHMFPFSSYAVPYSCGPDPKVCCQFDFRRLPQGPFSWFREILCGWEVVWGDYKCCPWGINPVPITAENVADRAQVLVDQYRKKAQLYEHNTILVPLGDDFRFDRDSEWTNQYSNYKALFEFMNSKREWNINARFGTLGDYFEVLERRLAEKQYDNDVPGSVRHSARGRGYKSSPASSSASLALLPVLSGDFFTYADRDDHYWSGFFTTRPFYKHMDRTLQHLLRAADIFYAMARWHSAEIDEHFDMSTLFDSLVRARRALSLFQHHDAVTGTARTHVMIDYGKKMVQALEDSKCVLAHSVQSLLGISVCSSQLHLRVDETYFVDRLPEKIVLKANSALVMTNPMGHPRREVICVHVDSVKRRVAAGGEEDGQGTNIPQQIGPVLFVNSEGRLDQFRDKFELCFVAELPPFGMVHYRLHKSEDMAHKVTIRQSINAAFESPIFELKRIGLREKTVSICNNHLNASFDASTGLLKSINQTLVELSFVHYGARTHNPSKQNSDDDGTSSGAYLFLPDGPAKPLPTEANTFLVVSGPIRKYIYIKANADFGIGHQIALDVDGQHLAILNHVNLANSNRGNVELAMRLRVPFMQEDNFFTDLNGFQMIRRRRQPQLPLQAHFYPMASAAFIEDTRIRLTLLGRQALGVANLQQGELQVMLDRRLAQNDGRGLGEGVQDNLLTESRFNLLLEHFVPSPSPATDDATIGFQSLAAHHSSLRLHYPPITLAGQLEHAASMSIKHFVSALRRPFPCNIHPVALRTLSHPTVYDANSSITRPRNEVALVLHRFGLECRLDSRIAESSCPTGLAETADGIDVSDVFHGRARTIRRGSLTLLYTNSTDVGRGEQIALEPMELATLWLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2E7</accession>
    <name>A0A914I2E7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I2E7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6688.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6688.t2"/>
        <property type="gene ID" value="Gr19_v10_g6688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6688.t2"/>
        </source>
    </evidence>
    <sequence length="481" mass="53570" checksum="3BD74CC7603F51E5" modified="2023-02-22" version="1">MNCTNPGIAFEGMALTVGMMDYYIQHYIFPLQFCLGVIGNSINLCVLLSSGMKNQANTLLSAMAFADLAFLLCMLPHSLASFSIFYKSIRFAYFYLLSKIHWVALANCFSTAATFLVLAVSLERFSGVRHPMHTRFQLRDTRLLLLIFTIYGLAFGLSLFHHLDYRVTIRVDCNKKRVLPSIHHISELNGTSPVLVRYVRIAKYVQSLFGVFVPVVAVAVLNVSLVYFLRKRQLLPRASTGSSGSSKKCQQQQQQQEFRRYSDVAAFQRQERKVTATVIAIVSCFTITHLPTLGPVVWEHFVAPLVTASAILNSILVTGKVLNFFLFCSSSAHFRRRAVLILKAHLFRGRSRKKYSSLALSNVPTQTNVTSVVSNNMHGTSPGGTMCNNNAVFATAARCSRNLQNAKTGPNHSVINNHQNKSSTPTYRMPKQSTLSLRDALLRQQSGSECDDLLPPARVDADGIIRNGSQSARHSRTEFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2Q5</accession>
    <name>A0A914I2Q5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2Q5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6297.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6297.t2"/>
        <property type="gene ID" value="Gr19_v10_g6297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6297.t2"/>
        </source>
    </evidence>
    <sequence length="331" mass="38104" checksum="C67EB6909AB4B6BA" modified="2023-02-22" version="1">MWSADAPATTMEAKESLLVKLYVQELASNDGTGELREFVCALDEQNLVMEEAFLPKQQVVQNLNCIFRNNLFSATKGNGDGLSSGRRRRKKRAMAFAIVLIAAVIILRLITFSVLHFCASGEDDHHNEDIAIHAYRRPTEIRIKLRYGDDELDLQGNNKSDHAYIVVGNKEYDFTGEGARVRENHICKSCPTKTFSFTPKLDAQGDITRIEDILNEMHNGKWHAQSHNYTFHSCIDFAYQFVCRLNNGVCPEKKRWPKEFVEFDQRWVHRESQNGRFSVFDWHYVTSEQNCEQLLDALPVAISPPQPQQMPERGAVSRKWRQPTNSMDEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3A9</accession>
    <name>A0A914I3A9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3A9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6218.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6218.t1"/>
        <property type="gene ID" value="Gr19_v10_g6218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23128:SF139">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS EPSILON-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23128">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS E (EPSILON)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6218.t1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40835" checksum="1339D771DDAFB299" modified="2023-02-22" version="1">MIAVDDGFALKLNIVLALMELLINLASLPASALNSFLVARTQLIHLNMKFILVYQSACLLVRGFGRFIICLGKLAIDPINAEHSEPARTIYLLGVYNRNFLAHVLIIERIMATVWLSTYEKQKRWLFSLLWSPLVFFAALFNIIMMGNSTSTLFNIVTNSSILIIGLLEFLLFVWIWHFNRRIYIRGFQNRVPSLSEKYQLSENIRIGRQLTPALICHFLCLFMNVLKLYWSQFEVPGYDYLLPVTTLLGSFLGLLIEITTIQFHPFLKRHLCRVLYRIFAFFCIQQLSRSNRLSSTLAQCPDRRMGQQNVNNRLGRSSIALQDIISGEVMPTSMEPERHFALLQKAWNAGPIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3R2</accession>
    <name>A0A914I3R2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3R2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6328.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6328.t1"/>
        <property type="gene ID" value="Gr19_v10_g6328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037229342" evidence="2">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="3">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6328.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19429" checksum="C1B1C7A67447F1E3" modified="2023-02-22" version="1">MLNFLPFALVFFLRFCGRVPLFPSSNSTAKRKTNEQKKCSSNCKMNRSNVFAVVAILIAILTLFRAVDCRATHGTCIHQGKHYREGEEWIVHRSFVMRCFVHYNHNRWETKSKYFLILFLLLILSVVGCRSLRGDRIPLNGQIRDVYGIWKCVQDAKGSTKLVQQQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5D5</accession>
    <name>A0A914I5D5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5D5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7476.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7476.t1"/>
        <property type="gene ID" value="Gr19_v10_g7476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7476.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9513" checksum="ECDCCCDE7752783A" modified="2023-02-22" version="1">MRRHFGVSRGGTDGTVNDIALYSNSPPLGTFFARTVCTTFVVVRCCSAPANVFDLCDWRWVENFCRIELSKRGPWGGWIASPIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6Q2</accession>
    <name>A0A914I6Q2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g7133.t3">
        <property type="protein sequence ID" value="Gr19_v10_g7133.t3"/>
        <property type="gene ID" value="Gr19_v10_g7133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF19">
        <property type="entry name" value="CUTICLIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="232"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="333"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="422"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="728"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="947"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7133.t3"/>
        </source>
    </evidence>
    <sequence length="1476" mass="159449" checksum="AE029AEB84F5B8A0" modified="2023-02-22" version="1">MPSTAFQNAGGNDENSSAANEALGADDAAPFVELFTGTTSSSSSWSDEEEVHIHGMEEDRQQTENGAEHDGGSTNRPHSTGRPTQAAHHQPRREQSADAADSGPVYASSAPTLCAADENPTFLRHLWLPEEPEGAPWTANFVRKMDSLEACARLCRDNVEPFGGRHFACHGFTYIGQHNAHNACEFFDDQLAVALEKKPPLGSQRGRLWTDMAPQLPKNYFERICLSIPSRCARLPFAFDVHPRRALSIPQEAKPLAVGQVDDRKRCLQQCLNTKGCRSLDFDTANLTCTLYAHSLHAALGAPEESTWPLGQLVENADSDHYENTCLTELDRCGTRHLAFILIRNAELAGFSVGVGKMSASECLSRCLDSPPAFCRAVQFRAPGNECFLGTERPFEPLPSDELDIFEPVCLPDPPRTSILECHGEQVFERVPNMELRMDDEPEDAAGEQPQPEQVHGTDMSGLTLEHCLDACILDESCVSLIFRPGAMDDEKSSNGTGTGFVGGASLCRLFPFGKADNRTLSVIHPNVDFFELSCSRTPLPSAMRKMLTMPPPPPLPLAELMRMRAAHHMHTTIMPTTATTMAPTIASSTHAKTKSQPVDAKRGEMAAVAAGKNGAMSIVSNDANVATANNTTVMVEATTVVEVPPHNLGTSGVPSLPPIPVQTTQHPQKMLRTNSTRSILSEATLSSSATFSGSTPTSSTPARTTTPSSSLSTTSTRQIQHESITECSATMQKSVLLERERTLKLEQRQQRHVNVPDGLHCERLCADALAFRCRTFAYSHHSRDCLLSSSAITGKTAPEFELLSQVNPNFELYSLVGQKGNCGNKWSTMTTTTASSTAIPEHTFTNDFADADPPFSTNASAEVEQILFMATTTQNGSAVIKLAKEKIIETTTNTTLVQHQDSDVQPVAATPPAPTPTTTTAKLPSTEREAAVTKTAVVEKGGNPLMSTPSSNLSRTSSTSSTTTTTTTTMMMSSNPMSAGGSSWMAPPAPVSVDGNVLPTATGRIGVEQIRAGVLCDPKGLNVTFKLVGRVRYTGVVYAADRFAHCRLFVDEAAEFAFYVNRPENGQPNWCNSVEANDELNVVLVMSNDEVFPLDVTTSDDFFFYVSCDYRGITTASGTQRQRQNAWPGSVSGPEPGPLFASAARRPQKVGQHRRPLADAEPSSQRRERVHLKILRDGRPVSSVYIGERLSAVVEGTDVEVDRLRVADCNATRVGGRVPRPSSIPLLDRAGCSLNPHIIGHMRRHADRLEASLSAFRIDGSDQIDIVCSVLVCRTRCASREAQCPAELDPHDIAAGAAVAARVHRASAAIGGTGKIMLKESPADLPSVAGDFLTVDQRIRVLVSEEEERTLAVADAEAVEERQLPRGGGGNALPAAESDVSFVGATPTTTDILLGGMASTAASGDLCLNPVVLLFLLLLLLLTLASLIVSLFAHWCRRKSGRRLSHNFYPATSTELSSHHFHIPRVLDRRSSYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6Q4</accession>
    <name>A0A914I6Q4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ankyrin repeat domain-containing protein 13C</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I6Q4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7411.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7411.t1"/>
        <property type="gene ID" value="Gr19_v10_g7411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="10">
        <location>
            <begin position="170"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7411.t1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52715" checksum="CE9603D39B604755" modified="2023-02-22" version="1">MPSGNGSAVTNDGQWLDENFPLHHAVFHNDVKKLEQLLEQGPAVRDTIDRVDTHGNSALHIACMLGRRECIELLLSHGASIGAKNNLEWNCLHEAVSYGDRNILEMMLTALKKQSHETLTGRLPLLAEHFSKLGDFYMETKWEVFSWIPLVSRLLPFDTFKIYKKGSRLRVDLTLIGFNDRGAVPKWERGDVSLLLDMTATDGRKAVLMDHQKKVYQVLHAKNRNLREELECLMSTDISSIHISTRPIHFVQAKSLLLFPKSEYVGKYKAHIYNIKGMQLVTQKRREHLSEEDLKLNKEMQSFFTDGNLPARDVNTEGPDPQHQRPSLSPPPQPGLNWSQYLRAADKNSHLGRQMHEKVSTKECNGTVAMSSDFPLSLDVVLDILSVLEPLNPTMAKLRNLCTARLPPGFPVRVEMPIYATIQARISFEHFNWCGSGEGAAPPLSAALFKIPDNYHEDPKRFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7D8</accession>
    <name>A0A914I7D8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7D8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7981.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7981.t1"/>
        <property type="gene ID" value="Gr19_v10_g7981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF9">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="53"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7981.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48915" checksum="56653016B984DA2E" modified="2023-02-22" version="1">MMRLLICDEELSLFDLNNNLTIVLLDTLWSISTLYNQVHCWLGLFICVFGSLANCVHIFVLSRPAMQKCAVNRLLAIIALCDIATMASYTVFVVRFEFAVDKDEPPLGYGFLWIVFLLAHVVCSIALHTITVYLTVITALIRYKTLKRVGSLWNHENIACPIFLMVAVLTVFLCIPTFLIHSIIPVTSTDPITRHNITLFTVGLAEFEQFDTCLFFKLNLWLTGIIFKVIPCVLLLLFTLALLYELEKNHRKRKLMCSGTTLAYRRHSAQSDRTTKILLILLIVFFCTEFPQGILSIMNGLFPNDIHQFVYLSLGELLDLLSLINCNTCFIVYPLISSQYRATLHNLAGCIRQLAAGRGWQAAAANINSRSRMSESKFVVTSRRFTLSSSTGSPSSKPSLTFFFVKSNKYSDDIYQQQQEIRFLEGHDLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7M9</accession>
    <name>A0A914I7M9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7M9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7386.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7386.t1"/>
        <property type="gene ID" value="Gr19_v10_g7386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7386.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7416" checksum="CDFC058403F1EE58" modified="2023-02-22" version="1">MVDKSHAPFIAILLTLVTALLIFIAISRPSVHVQESVRKDAAAIGEVSSQPQNGSTTLMKTIRRVGTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7Y3</accession>
    <name>A0A914I7Y3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM9 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7Y3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7571.t3">
        <property type="protein sequence ID" value="Gr19_v10_g7571.t3"/>
        <property type="gene ID" value="Gr19_v10_g7571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000195">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008853">
        <property type="entry name" value="TMEM9/TMEM9B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05434">
        <property type="entry name" value="Tmemb_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037341026" evidence="19">
        <location>
            <begin position="22"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="431"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="833"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7571.t3"/>
        </source>
    </evidence>
    <sequence length="869" mass="97022" checksum="1976DA1DA9EE04C4" modified="2023-02-22" version="1">MNLKFVISVLFVYFFAHSTKANFEDTRCRCTCPSTEYFSSKNKTPAEHYRRYYTKTNLNSANCNTQAVVKQVVLNDVDASRLDAFLANCNCRFESRNSLLLKVVVIFVICVLLGLGSYMMYLGLPYLVVVEPMLRREQPFIPYRRHGDDDDDMEENIFANPRTSGVEEASSEQQRPSELQMRSKQANQQHSGGTTLHERVLNRVASEQSKWKNSVEEQRRNVLDHSQMFSQMHRIRLASPLGLYIRWRGIHSFRRGRMMKTADAVGQTSTGSSDQAWWLRLIAPSRASPSPSTTDYEVFKQQDSIGESGTNSNKPVMVVRLADAPGGRLSTFLGRVGESVVIYVAKLVTLAVLFVGGCQLLLWYFGIKKVTVHTGGTSLLESLTDQPSWTTDKVDVTFEDVRGMDEAKSEVEEIVDYLRDPRRYTNLGARLPKGVLLVGAPGTGKTLLARAIAGEADCPFFHAVGSEFDEILVGQGAKRVRELFRLAKENQPCVVFIDEIDSVGSKRTNSAIHPHANQTINQLLAEMDGFEQNQGVIVIGATNRVDNLDKALLRPGRFDVQVTVSKPDLPGRKDIFRLYLDKIVHGDIHITQLAKGTTGFTGADIENLVNQAALKAAKEGAKEVNMRHLDEARDRVLMGPERIKGRLPDEEENRNTAYHEAGHAIVALFTKHADPIHKVTIIPRGSSLGHTSQLPEKDRHQTSRAQLLATLDVAMGGRVAEELTFGQENISTGASSDLRHCSQVAEQMVKVFGMSDRVGLRDFSLEPIESENGFRADRGPGTSEMIDQEIKNLLQQSYERVKDLLTRRKKEHLLLAEALMEHETLSKSDIEKLLKGEKLSKPPPPPKQQQNKGRTLAIGKKAKEEGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8N9</accession>
    <name>A0A914I8N9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8N9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8516.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8516.t1"/>
        <property type="gene ID" value="Gr19_v10_g8516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8516.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14115" checksum="75EA6584B906AA16" modified="2023-02-22" version="1">MGRRRIPMTLMALEDCSYKVLGLSKLRYQATPAQLKTAYRRKVLKYHPDKGQAADTDDTSLRNEAVFACIQKAYEQLGLSEDRQRAFDSVDPQFDDLVPDSVEASNFFASLGPVFERNARQAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I991</accession>
    <name>A0A914I991_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 13">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I991"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8681.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8681.t1"/>
        <property type="gene ID" value="Gr19_v10_g8681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060158">
        <property type="term" value="P:phospholipase C-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003977">
        <property type="entry name" value="Guanine nucleotide-binding protein G(q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000654">
        <property type="entry name" value="Gprotein_alpha_Q"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF365">
        <property type="entry name" value="EGL-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00442">
        <property type="entry name" value="GPROTEINAQ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="368"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="460"/>
            <end position="461"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="485"/>
            <end position="491"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="510"/>
            <end position="514"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="579"/>
            <end position="582"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8681.t1"/>
        </source>
    </evidence>
    <sequence length="664" mass="75979" checksum="50B33C74A645BD0E" modified="2023-02-22" version="1">MELAQKFNEEDGKQGSLRFILFTYPTELQPDQLSGDGASGENLENGAMNGGGSGTMNGVNGGGTPLRETTPLMNFEANSSPRPTPVPEEQGSDDDDEPSESARLLTPGEIRKFRLSFKGMDSSNSNAVRQRREYSPLLGGETNSLLLGNGTHPSWSLVVRLGHNGSFSYGHGTVKRGIGARPLNDNSTRHVQRELLQQQQQQHSSPTTFSMKVKHQYIFVRTAQLAILNWPLRINQIHALIEYLNRATITSLALNPSPLAHHPKFLTRRAVPFERLIWHKEEELNGNHNPSALKKQRQRQQGLLPIVRRTPIGKTGRLTGVSVGPMACCLSEEAREQKRINQEIEKQLQRDKRNARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSLEDKRQHIRLVYQNVFMAMQSMIRAMETLLIPYGEPSSEEKANEPYVSYIAELWQDPGIQEAYDRRREYQLTDSTKYYLNDVRRLAEPNYLPTEQDILRVRVPTTGIIEYPFDLEQIVFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVECDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLAEKILYSHLADYFPEYDGPPRDEITAREFILKMFVDLNPDAEKIIYSHFTCATDTENIRFVFAAVKDTILQHNLREYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9A1</accession>
    <name>A0A914I9A1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7809.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7809.t1"/>
        <property type="gene ID" value="Gr19_v10_g7809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032484">
        <property type="term" value="P:Ral protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042227">
        <property type="entry name" value="KBRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1246"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="6">
        <location>
            <begin position="1209"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="823"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="823"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7809.t1"/>
        </source>
    </evidence>
    <sequence length="1299" mass="142286" checksum="B6D858BF7DEFD20B" modified="2023-02-22" version="1">MRTKVHVVVLGPKKIGKTLLLKSLMSQHESSPCTSAAPTDDRYVPTVEDTFHVQFTDVRLGEQSQRAMLILFHDTAGIANFGNIELRKPYLQVADAFLLVYSVLDPSALSRMEALKKYLEREKVGTSKERKEVPIVVVGTNCEMPGKKVATESALHWANKEKVRLFEVSARDRSSTVELVQHLSERLFHSLKDSKFSLSRKLKPEKSNAQIPENGPDRLNKCSPAHRPARLHNFERFNPNYNLHLLLLPTPPPTKRESAKLLFEEHPMELQKQPVLATKEQLRLAELTQTGNDVTTAHDDIALQKRVKKVIELTRCTQSQAEVALIDGEGNVEDAVSRLLDNPEELVLWSQQGKNKKPKVATSLVASEFKVGQGTHGRRADSQRGRPRQDGMGQQNSGNGGQKQYQPVHSRSSTRSTQPKEPNGPSEGPKTRSERQGFKGQVRTFTGGAFRRERGTKDQSTKPDATNNGNEGAHKGDVQGWTKEGGTGNVGWGDSKGWDDEKKGGDGGDSGFSTVEASYAADTPGQNKDDEWKNGPRVFMPSSTAATVTETSPNNTAKSTSHWPVLDNFAPSEAVETIQQKPKTFAAVAAAKKPQPTTMMPTPEELISTSPSIVFQKESSIPKVSDEPVVEWSSSIDWGNSMSPQPAADRSEFTQHPPDQSASTSTSNIVFGTVPVHSMGTNVNQEYTDQLKSAIGLMTGSQHQIGSGITHQPASASNSCELAADYIQQHNHLQHMALNNTMEMDQSREKFGFHFNSAKGNENSWGHQQHISSPDRSVLKNSTGTMLSTMTSIPTTSSSVSVHFNATSQQAQAIEAHQRISNGATRSGNPLSFSDPASVNFPPSAGQPGGGSVVGHVIPSSFAVQPSDPTPAAHQQQQLHPQNKQMYTPSANPTMITAPPTMQQHLQQQQQQAQTIFHQTSAATAVPQFPNYNMPYMYSPVAAAPALPAPNTELDRFLIQQYGPPYSQLDLQMGAMSIGPATTLAHNHHRATLDSYMENKFGQQQQNVNQAGNNGPYQQSQQSQQQRGLVQSEQTAALLGGPPSHVGPPPGFGMPTAPAQPSYVQPANIHSLFQMPTYPHPYQHPQYMMSNANRLQTAQRPAQTSPPEGNVSNQRRGGTDSQGRFAALWQPHLQPKISLLHVAFGATNDRQRNFEMSHTPPPPYPGDVTDAMKVPFAAQSHQHQGGIPVYPPPPTFGASNVHVTLPTNVPIVVRARTAPFGPFPIEMDCPYCRNHIVTHTQQIPGALPWVIMAVCFVLGFFLLFIPWCLCCLPFCIDSCLDVLHTCPSCKRLIGRFSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9E7</accession>
    <name>A0A914I9E7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9E7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8118.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8118.t1"/>
        <property type="gene ID" value="Gr19_v10_g8118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF96">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8118.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29180" checksum="D38ED7677A55F40F" modified="2023-02-22" version="1">MDTKQLENLWSLIVAMLFFGAIFGSLLIRPLADRLGRLRVLIVGNLFGAFGLFIGALSYFLNRFELFFLARFGIGFSLALCLGLAGIFLAECSPKGCRGSVSMSTGALLQLGTVFGSLMAIPTVLGSSSRWWAMFTIEGIQLFVTTILLALFAKESPSFLLLRGKETFARRSLAFYHNCPDDTLDERMKEFSSDTLRSVRQRSVGLFQLAKQRGANRKVSAALFHFPWHSAELPLLMLLLWSFSVRRESLSIGLPSTMLALPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9T4</accession>
    <name>A0A914I9T4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9T4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g882.t1">
        <property type="protein sequence ID" value="Gr19_v10_g882.t1"/>
        <property type="gene ID" value="Gr19_v10_g882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g882.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17057" checksum="C7966040EC935907" modified="2023-02-22" version="1">MDDALDKVFNHLLVMLENRGPGDSGYPLRDWWMVPYLNLKSEAQMRFNMSQSRARVKVEQTFGQLKRRFFANAIGYRMDLNNIPNCIIASCVLHNIAKQLNLPEITEEEQPITDDQPDPDIAVENLADEQIDATNIVVTWVAGLHAIADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA65</accession>
    <name>A0A914IA65_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM129 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IA65"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8102.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8102.t1"/>
        <property type="gene ID" value="Gr19_v10_g8102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018801">
        <property type="entry name" value="TM129"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10272">
        <property type="entry name" value="Tmpp129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8102.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32390" checksum="85A9E76048DED1E5" modified="2023-02-22" version="1">MELGIFASEFLFFLLLSVFFSLLLILPSDALHSAGFTIPKIFANLLGDERFNFVEYHLRRTLLTAFVHSAIPFICFVGLELSVEQPVFSLIPNNFIQWAALFSVLIATASIAILSLYRGNNWERHPFVQTLKRLSENGNWQLIARELNDEVRAPQLYSILYKDCSRVLVTHLWLIKITNYAVKLAPISDSQFLVIRSSPLQQTLSGQQNFPLVDNIAQSNDHIIDLQIRSISGLFEDFLIRKSWTTFVISWVVPSMFWTLLSFLSQCTNFSWTSFWPRSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAH5</accession>
    <name>A0A914IAH5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IAH5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8105.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8105.t1"/>
        <property type="gene ID" value="Gr19_v10_g8105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="684"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8105.t1"/>
        </source>
    </evidence>
    <sequence length="828" mass="92359" checksum="F0B71AC25040616D" modified="2023-02-22" version="1">MPNTKKTKGNGGGNGGGLLLQPPEDRQLLAHHQQKANGRGGGGTPSPTPSDNDGTIDGGFSTLAPIGQNKLSSRVMFSSDDVMDASEDDGREGWDNKMQFFMGVISYAVGFGNVWRFPFLLQKNGGGAFLIPYLIMMIIEGVPLFLIELGIGQRLRMGSVGPPLWCPTLWRCITIFELPWSSCPTLQDGVTPVMECANSTSPTNYFWNRQAIDTTDSIGDFGGFNWKMTGYLVFSWFLIYLCVMKGIKSSGKVMYVTATFPYVVMTMFLFRSIMLEGATDGLRYMITPNLYRLSEPEVWLEAATQIFYSMGLGFGGLIAFASYNPLKNNVKKDVLKMSVANLLTSLYTAFVIFCVLGYMGRKNFDRCIEKDMSLILKVQPGLFRNMEEVRGNISVDEFTDYMRYDFRETKFSEIVHHPSYQKCELGHIIAQAAEGTGLAFVVFTEAILQFPFPPLWAILFFMMLLMLGLGSMFGMLEGVITSLNDAKMIPLSKPILAAILCTSACMIGLVFTTQAGQYWVSLFDQFAGSYALMCVAFFEIIAVIYVYGCDRFVRDLQYMTNEPVGLYWTITWRFISPVIMVVIFVASVFKSFSDVPKYSAYDSTTTHQHNVPYPTWALFIAFGLVVTSMASVPFIWFVRKFKIWRVEPDIPVASKCLGSTPSTTYMLRSDLSFNQILESRGSELQNIGKGGQRNGTVSGGGGSAPVSAKHHRHHNGTNDPNYNNHHTWHSSNAPPRGWRQQQRKKGSDTDLSPAVTNADSDKMRKQTQTSTGRKKSLAEDGRGEDGLGPRSERQEEKHQKAGLSPEGLPIDQLTPSDRTRERMDKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAN9</accession>
    <name>A0A914IAN9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAN9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8434.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8434.t1"/>
        <property type="gene ID" value="Gr19_v10_g8434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8434.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9133" checksum="757E85ACB2263CBE" modified="2023-02-22" version="1">MAKASDAARARRAKAARRDAKRRRAARGRAGHTIKASQRERCMVCMTNVSSITRMTMGCVHEFHRRDEHSIKQKQLYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB89</accession>
    <name>A0A914IB89_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IB89"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8990.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8990.t1"/>
        <property type="gene ID" value="Gr19_v10_g8990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8990.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33185" checksum="BB08879E351D24C5" modified="2023-02-22" version="1">MTIFNDPVVLSGAKAFVAVFMILSNSILVFVTYKTKALNSTCNWLIAANSACIALYSLTYFVQFGIVLLRPSGIPLWQCCLLVPVPLFFLCCQYVLFPLIALDRLIGAIFPLKQMDNRYKRRYMFFALVASTSFGLFIVAASINNSIISEDLVFCMTSEPAPTFFANCSWVLNSGSAILYLALWVRIKLLSSCVSQKTKFNDAVTRKILFSLVAIFLVEMCGWASYWAVFLLIHFDVSEATKWYMLSYIGFVMQLTLSLNGLILYALRQIVTIERPFEQSFGLAKLPSQHKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICM8</accession>
    <name>A0A914ICM8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICM8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9384.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9384.t1"/>
        <property type="gene ID" value="Gr19_v10_g9384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9384.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11653" checksum="1697067818B3B5B6" modified="2023-02-22" version="1">MFDDANTYLLICSGGAFAVVQSIADSQNKFQQNMDLYTFYNDDKHLNSLAYWHYQLKNANESTTTLLCKAAIDRECLARIIVASSYEMSSQLSPYAAFLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICT2</accession>
    <name>A0A914ICT2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP synthase F0 subunit 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICT2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9016.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9016.t1"/>
        <property type="gene ID" value="Gr19_v10_g9016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9016.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14192" checksum="E912F4496FF2DA11" modified="2023-02-22" version="1">MYGVKRVSANNLETFFFILFLLIFAVAAAAYLWVKGTEDEERSRYKLFLECVLILTSVIPPELPIELSLAVHKILFIIQFEFYCNEFSSNTIATANQKCVFQWGQLAGTFRMGRNFNYLITRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFF3</accession>
    <name>A0A914IFF3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFF3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9743.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9743.t2"/>
        <property type="gene ID" value="Gr19_v10_g9743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="2">
        <location>
            <begin position="194"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9743.t2"/>
        </source>
    </evidence>
    <sequence length="280" mass="31474" checksum="E84AF5DF41E12239" modified="2023-02-22" version="1">MPVLTEYKKLEDKIDWLNEDQQKLVSIDQFLLMQSDQKALLQRLNTLEQKQTVNSEQQKTDQKALSEELRQMKEELKNTKELVDRKLEETNGGSGDKDGGVSEQAATDNRRVDTFVEATRRREKQKEQQLNIVDLQKTVAKLREIVPNQWDPAACHDRLALIGPDRLIVQYNGETNLDKHYSVKGRALENPSNHNKRCSHATNGRPLIGGKPKFGVGDVLGCGVNLATRQITYTKNGERLDTANLFVDSAADLFPCVSLGKPGTEIEANFGPNFKFNIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IH14</accession>
    <name>A0A914IH14_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IH14"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9816.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9816.t1"/>
        <property type="gene ID" value="Gr19_v10_g9816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="238"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="340"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="376"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="414"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9816.t1"/>
        </source>
    </evidence>
    <sequence length="601" mass="67660" checksum="818D59FAFF33B75E" modified="2023-02-22" version="1">MINRFIRNFLNGQHIICKVQQIQAVRVAFLHQCAKNVCPAAVLSCGACMASSSSSSNRPSNRSKLLDAYRNKRAANLQLTDLGKDAVEFAQDPLGSRFIEQKLERANPTEKAQFVDALRGHVLELAQQVYGSHVIEKALESVDKASQIEIINEITAQVIPLSFHKYGSRVIERMLEHCTEQQKRPVLEQLHGNVSTLVTDKYGSFVIRHVIEHGLPEDREPIVRSLQEDVLNLATDQYGTFVIQHVIEHGLPEDRERIVHSLQGDIMKYAQDKFGSLVIRKCLTCGTTDQKKALFDNVCVGGPKTLQNARQLMADEFGTHVIRKFFECGTDDQKAQLVDALRGHVLELALQMHGSYVIQTALKSVDKASQIEIIEELTPRSCVIRCIKDQYGAYVMNMIFELVEPERLQFVVDAILSSPSDSVASLSLHECGYRVIQRMLEHCTEQQKRPVLEQLRDIVPSLVTDQYGNYVIQHVIEHGRPEDRERIVRSLQGDILKTHYKSICSIIEKCLIFGTTEQKNALIDQVCADDGTGKPPLLQMMKQQFANDVVLKMVDGADSAHRDKMMFAIEEHIPALLKRQQLLAKRAGGAVVDKRKKPNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPG0</accession>
    <name>A0A914GPG0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPG0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10212.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10212.t1"/>
        <property type="gene ID" value="Gr19_v10_g10212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037379829" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10212.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9478" checksum="DEA79FCE759FAA2E" modified="2023-02-22" version="1">MCNSLLLLFLLFFTVATISARLTHQSFGYILNKTNSQHRHFHHSQAVQQTSKNIYNKNRCYRQPPASERVQKRWASKNGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPH4</accession>
    <name>A0A914GPH4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPH4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10137.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10137.t1"/>
        <property type="gene ID" value="Gr19_v10_g10137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10137.t1"/>
        </source>
    </evidence>
    <sequence length="678" mass="78897" checksum="7E42C87F4FF810DE" modified="2023-02-22" version="1">MSDNESDEEQQQQMEKIFICADVLYEVFTFLDPFELGLKMALISDRLDVLVDVHFKSREWSLGSMEIRRAIVKPRELSLSNWLRIRRATDGNGAEIVKLSGERLPIPQEPPPGKVMGFKHILISYVDQTVIEFLQRIRRLFDSSGTNVFIGTLNNQSHSWENIWQNIWPFVNDNICGLSLDSSQLNRLRRFSPTILRNCANLRSIHSCWLFPEFPAEDNSGASSHQALAKWLITPRGDGLPKTFYCGFYMGGMEGLKRSFVNALEPVNYIIRLMHPSFYGIEPFELKNNWTREQLTLRLIGDDWLLVRCPIEREEDKWTNWEKEAIEWQWNSQWNRITINFKDRGIGDGMVGSEGPSADLIGEHEAFIMAAFPCGSGGFKCLIPNFSFICADVWHGIFAFIRPIELGLKMALISDRLDVLVDVHFKSREWSLDWMEIRRYGNGAQIVNERFGEGLPIPQEPFPNKVIGFELISISYIDQSVIEFLQRIRRLFDSFGANVDIRTSVDQFRSWDIICENIWPLVSDNICGFFFVPLSIGPFATNLTGDSSQLRKTPIDRFHWAFSQVSGRRHRRRFFSPSRGQMFESSYFQSFVNASEPVNFIIRPLFSDIEPFELTNNLTGEQLTFRQIDKYKWLLVRCPIGRDAYKWTNWEKEAIEWKWTRQWNRIDITFNDRDIGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPV8</accession>
    <name>A0A914GPV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GPV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10068.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10068.t1"/>
        <property type="gene ID" value="Gr19_v10_g10068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10068.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18897" checksum="C713A8C6B14D0D21" modified="2023-02-22" version="1">MRPLPENAPAEWKRFYDSHARTRVAIECAFGRWKNKFLCLKRELRFTDPRICSSIILACAYLHNFILETNEEEQSVMNEALQLTQQYQSQHSEATLLEENEPLSQNPRERRRRGMELLNDHSQHIDKVPDGWVCARKCTLEPPMRRFSVVICFVPVIQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSM5</accession>
    <name>A0A914GSM5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSM5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10017.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10017.t1"/>
        <property type="gene ID" value="Gr19_v10_g10017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10017.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11797" checksum="DE6335E02B0FFD2C" modified="2023-02-22" version="1">MPSEWASPLRCGSGTRTWMRPRVGVEVCYGENRDSCCCCCCFLLATYEEMSENMSTLQKIPQVLAVAVRVVEVLSLVESSGLPPVLRRVAVPKFPIRQKQGPKTMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSZ1</accession>
    <name>A0A914GSZ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSZ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1093.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1093.t1"/>
        <property type="gene ID" value="Gr19_v10_g1093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1093.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8717" checksum="020E4C4B0A0C981B" modified="2023-02-22" version="1">MADTFGEYKGTEQSLTFRSGHTEQRADATTSGEMLDLRSARTWHWTMPRGDQAIRWTEVKFGTNLMEGRTCEAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTI6</accession>
    <name>A0A914GTI6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTI6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10268.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10268.t2"/>
        <property type="gene ID" value="Gr19_v10_g10268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10268.t2"/>
        </source>
    </evidence>
    <sequence length="106" mass="12529" checksum="D9E676ECDD357E21" modified="2023-02-22" version="1">MGPPPPLFFSRHPICALLAAVVLFQILVFADWVDDVIEIVNQKMAPWHALLEKYERALATMESEERELSRIKQLQIIEKKIEMHQKKLKKLMLKNLIPFEQECKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUD7</accession>
    <name>A0A914GUD7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11291.t3">
        <property type="protein sequence ID" value="Gr19_v10_g11291.t3"/>
        <property type="gene ID" value="Gr19_v10_g11291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036927245" evidence="1">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11291.t3"/>
        </source>
    </evidence>
    <sequence length="338" mass="38070" checksum="44C9DF6452748413" modified="2023-02-22" version="1">MSFFVLFVESLALSVLLPLLFLHHRPSNATAEGQFALWSPPSVPTADLFFSPCTFPLIYPFGRGAQPKKEEEQLAHKRQHLRHPSRTGRVENDSLCHIHRHIPFICDLHRALIVTHRDALRLASVHRQHAAVLSDEASTSPNFVVLIVRQLAQPTSPLYVTRNSSEFGCLFRLPCETMNAETVQKFVRSTKVFMRVCPTSQRDLYASVLFNRWSQHRSASLGAAGLPQNGKKTFCRHPPMVLAIGLITNPRRITSVTLHTDNQRLLPFLVNVQFECTNMLLQGKPLIDVLSDLTNRAGHAIRDFYVTKGLVLFALVAEWMVCKIGWAADWSDPSCACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUQ3</accession>
    <name>A0A914GUQ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUQ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11512.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11512.t1"/>
        <property type="gene ID" value="Gr19_v10_g11512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="136"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11512.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38573" checksum="E9F0227AAEF3FDBA" modified="2023-02-22" version="1">MPIPTESTDVMNITADPECWPLNLANLDPPAELRLLRARIDQLERQQTTNSSTSIASFNLLTSRRYREKLMKTERELKDTKALVGKTLEQMEECKQIAKLELNELGNSTKKEFEKAMNQLKGELFAKMEEYQKQLQQNIDALTEAQKGNGLMPQQNRWDPTACHENLMLFEPDRLIVQCTGKNCGKYWGKYYSVFAKRPLSNKNFGNYYYEVTILEKECDVYIGLATKQMPLGVWVGWSEGTYAYASNGTFWGHDVEGCSYTNHGRPSIFRGVPHFGVGDVIGCGVDLATRQIIYTKNGRRLRTIDLFVVSAAELFPCVSLYFGKIEAIFGPNFEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVW4</accession>
    <name>A0A914GVW4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g11824.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11824.t2"/>
        <property type="gene ID" value="Gr19_v10_g11824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22966">
        <property type="entry name" value="DD_DYDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049630">
        <property type="entry name" value="DYDC-like_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172:SF4">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="846"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11824.t2"/>
        </source>
    </evidence>
    <sequence length="1390" mass="156090" checksum="B0B3478A611BECE2" modified="2023-02-22" version="1">MRLDVIKHRRVSLKVPGAGDEHSGDDDSSQQLNENNGLRQRRKMRQTLRISVDGGNPLGVAQNGWPLSPEGHLAVEEVNRWIASGDLAQLETLVLAGKADLLLGEQHKENFIFGHNRAKAFLKDLPEYKEKYDIFLEAIVDGDESTVQKLLVFRQLGRSRHPRTLATAMHLASIFEHPNILRALLDNDKSAIDARDSEGRTALHYAAALAGTLREDVQPDNGKGHQPQEEKLECFDILLDGGANESLLDVEGYSPINFHRTPRLIDMDQIRGLNRFPLRAGDRVDKLIADRDVRVLRDIVLAGDYHSQIRDRIFPPESRDLAPMLAHLQMRIRAIHEAIRDDDQMTLKQLVDDWDVAAGRDEHGRTPLHVAVLHGRARAARYLLLMFPRVVNLTDKASRSPLHYASCLPDEQQRAQMTRILCRAGAESAAKRQNDEADGQDHHVESAQAMLVMNELRRRDGMIGDQEEEEEEEPDQEDSEDIEFGDGVLLRQGRVGGGKARDAMRRKSAYTTSILNGANALSADGDEVDSEVENRVLNIDFCRKQYRELEQLQFEGLTGEVWRVVKKHLGNDLLVKYIYAYRQASEPFGVGEIVQARDARGLAPLHIAVLKERHQMVEFVAQTFSDFINIADHLGRTAAHYAAPQQNAIYDTLADLGADTQIADKNGFTAARYRQHPEQMVKPLPIVSAEADAGGGARGAADYRRTMLRHSDPSMDDSNSTMFDPDAPSDEQVKRWLTIGDVQQLEQIVLDGRAHLLADKMSTNLASAEFLQGVPQYQSKIDAIHKAVEEGDVRRVKSLIDRNSLATARDTHGMTPLHKALLYGQTNTVRFLLAKYPHCVNETDHAGRTVLHYAAADANGEHMIKVLQKAGGDAFIEDKYGHTPFFYRTHGKRLNIRTLKDNAVINNLIAGQLNRTLLQDLEEDITDWVHTGNIGKLEELVLNGYADLLLGRNHQVEDAEAVSFLEAIEQGNLRAVKLLTDRKKLALCRDCRGLAPLHKAIVFGQIDIAKYLIRNYPQSVNAMDQNKRTPLHYAAALRDGGYMYKLMRKAGADPNIFDCHGRPPKYYLRYPGEINLERMRMDTKQALKQVLHNRVAPSYLESNIQQWLREGNLAKLDQLVLSGCGDLLLDKKTANPEAHLFLKELSNLLKTIDAIHKAVKEGQLVPMKGLMTGKRLALARDRHGCTPLHTAIIHEQTEIIRFIAATYPTVLNAPDYNKRTAMHYAAAARDGGHYLKILGKAGADPMAVDNEGRTPDYYRRNAVFDLKLMKERDVEEVPLEDGVMPQHGHVPPDDHGWESPAESFSPQSSGVDTGRRDGDDEEEDLEKRRFERLLHEKLDMPTSDNGLYLARTVAPVLTKALAEVLLRRPANPVGFISEWLVRYIEAGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVX2</accession>
    <name>A0A914GVX2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GVX2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11684.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11684.t1"/>
        <property type="gene ID" value="Gr19_v10_g11684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11684.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12349" checksum="44957C36F9A19AD2" modified="2023-02-22" version="1">MANPGLPNPRLSRPEGQGTTLTSKCQPTNFIHFRTFNRRTFNPWTNPFGDGQRFDSPEQCAANGSTTAWKYRDGFLVSEEGIGKVLDGIIRRTREEYENTLRRLKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW66</accession>
    <name>A0A914GW66_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW66"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11738.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11738.t1"/>
        <property type="gene ID" value="Gr19_v10_g11738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11738.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8522" checksum="4B3CDDEB5DD958ED" modified="2023-02-22" version="1">MLWSRFSNGARPKEPRDENAPPPPSKRLSIRQTHKPGMVTGLFIIDERVRRRLQTIGYTTPIIVCAKYAVFVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWR8</accession>
    <name>A0A914GWR8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWR8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11116.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11116.t1"/>
        <property type="gene ID" value="Gr19_v10_g11116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11116.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39494" checksum="2F656A15BB11EA85" modified="2023-02-22" version="1">MERLIATFKKQKGSDGQIQNQCRPSGSGTGVLVPRIQITQSVFDETEEEKWLVKMKDAPTIIVEEKPPEAVESTAKKPPLGTALTAFLARHVQQNDEEQRGQQQQEGLLCAQKYQDRAAIGRQSTGTLNRLILVAQALESEVDWRRRSDVSSARIVLTLRMANIVLLLFVNLLIFTGVGHYQDKNGTRSSLLLTMNKWYFGTGYTFDDLPPTFSEIRLTAQFCAAILSVAMLLSSISLHFIHCFRLKHSKLLCIFYSFACVPIALFIFGLEMHYSACPWLDDFLNRQIMRRNFATMEKYFDTQCGINGWALAGIFSLLSCGLFISDGLIVTFFKSDETHNSEPEKQEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXV8</accession>
    <name>A0A914GXV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11387.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11387.t1"/>
        <property type="gene ID" value="Gr19_v10_g11387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11387.t1"/>
        </source>
    </evidence>
    <sequence length="588" mass="66258" checksum="5FCF29650A9BBD8F" modified="2023-02-22" version="1">MPPAMRCPVPGKCDQKISFAYEQGCRFLGILWIIKSSVENVFRPLHQQHSSSWQCSCTARPVRLGIRLFNRLAHHPHAHFQNDDSLLNWVHIYGILHGHLSSFPLNFWLALLFVVAAISGTMLIILLMMLCVENAFAHRLDITVHKNGLTVIIEAFLEWLYGFNNFRVAFLFMLLHDAPITLANFFLLSACRCTGPNVLSWPLLLSSLAMALSLSWRLCLLRFAYARLVFRPSGDSNSAFPSRTSQAEGNTQLDEGWAIRRATAAVYGVQRGKSFCGGTASGTLYLGENDDGEQRCLRQCCGFWLSWVLLKSVDLLFCALRRLLCVLLSVLFCLACLSVGCAPCLHHYTCSRNSFSHRHKCAKSFVRNCTLLFHYVVFGFSLCFSVFLILLNVILIFSTQLVGPNQWPPEINRLCISVSPHQRIVRPLFLSESTFFLSSPQPIHPGKNKEGNASLQQSPLAQCKPLWDLPHQQTFLVKWAPGQNRLSPSPWQARFPLQGGSILAVSVHFFSDHSDEQSPRHTLLYDIALLTFGADNLTKTAECARQRFSGWFFANARNDLGFPYFWGCSPTISIRKGALINCLDLTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY47</accession>
    <name>A0A914GY47_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GY47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11450.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11450.t1"/>
        <property type="gene ID" value="Gr19_v10_g11450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000505">
        <property type="entry name" value="Splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="306"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11450.t1"/>
        </source>
    </evidence>
    <sequence length="434" mass="46517" checksum="1BF4CC5D8CE07ECF" modified="2023-02-22" version="1">MSVLVTERNQDATIYVGGLDEKVTEAILWELFVNAGPVTNVNMPKDRITGTHQGFGFVEFMSEEDADYAIKIMNMIKLFGKPIKVNKASANEKNMDVGANLFVGNLDPEVDEKLLFDTFSAFGVILQPPKIMRDVETGSSKGYAFINFASFEASDAALEAMNGQFLCNRPITCSYAFKKDTKGERHGTTAERLLAAQNPLFPQDRPHQIFSDIPGLRPMPKPPLPMSLQGQNDTGIPPLPPAPPVPFPHGMVIPPPPGLGSIAPAGMAMGFLPHMAMAGLPIPPMQMHQMMAPRPPMPPHMGQMFAPPPPPMSRQSIPPPPPPPPQPPTPVATPQPPPPPLSAPPPPPPHVRETHNVVSTAEEAAVRKLMAHGPYGDDVFVVVDPTPAAAALGANASSSNRQTDTPAHPSVRSFIAFTFAAAATVGDHRMVGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYZ9</accession>
    <name>A0A914GYZ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYZ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11701.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11701.t1"/>
        <property type="gene ID" value="Gr19_v10_g11701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11701.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19975" checksum="BE5B6F49EB5A7799" modified="2023-02-22" version="1">MAQRPTQQQQQQQQQHEQGFWLFDGLSEEPYGLLPLVNLAGKGGPTSVKSVQRIGSYQWRLEDDEPVIIVPGMPLESFYWAGGRLRQDGGVVIYNVNHLKVRDGQLDSAILAAKLFGTKTNKEINFDEYDVITDAINLQKLFAFAQEDSFALTVSGWEKRCCCPEWRPLISWKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ87</accession>
    <name>A0A914GZ87_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ87"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11763.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11763.t1"/>
        <property type="gene ID" value="Gr19_v10_g11763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11763.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37502" checksum="C0E29D14044049E7" modified="2023-02-22" version="1">MSDNPSKAKKLLKEIFICDDVLFEVFKFCGPFVLGLKVALISDRLDFLVDAHFKSKEWSLGFLAIRRATDGNGAEIVKIVGNGVERRLAIPQNSLPDNVIGFEHISISYIDRSAIEFLQSIRRLFDSKEGTNIVIGTDNGQTRSWEIIWHRFWPLINENICRISLFSSELARLRQFSPTVLRNCAKLRLVESFDLFPEFPADDDSAGTSSNQALAKWLHMPRGDGLPKMLRCYFYLNRVEALKTAFVNSVVSVNFIICLKHWPSDDVVPFELMNNLTGERLVLRCFDGSFCPLVRCPIERDEAKWANSLTMNSSTMELIDANESPSEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0Y8</accession>
    <name>A0A914H0Y8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0Y8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12621.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12621.t1"/>
        <property type="gene ID" value="Gr19_v10_g12621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038000040" evidence="1">
        <location>
            <begin position="29"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12621.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="20959" checksum="78834D569C063E2F" modified="2023-02-22" version="1">MTKSLLFSCCCAIIVCLALMAQDKSVLAISDDDGVQQRFARFFEGGQLVRVKRACGTDRCSQDRQCDVCCVCSEGFCCPKLAISLHPSVLVPSVVEQDGINSIVSAGSESWASPSPMPRARASSPSFPFPNFIRGVNGAQSGGHNALPSLVAPDGSLFGKRSIGTTARAEDEYAGEKNGIPLACGLEAVNVHGEMIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H118</accession>
    <name>A0A914H118_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glutathione synthase</fullName>
            <ecNumber evidence="5">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914H118"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12951.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12951.t1"/>
        <property type="gene ID" value="Gr19_v10_g12951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="723"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12951.t1"/>
        </source>
    </evidence>
    <sequence length="947" mass="105450" checksum="FE6BBF0143676528" modified="2023-02-22" version="1">MGQEQQKINFSNILPSSQNNSSSSSSSFFSGYRINMMLSASAAGSILGSVPVTNLIAKIGLRNTAIVYTIISIFSGAIFPVSVQFMGFIPSLIVRLLQGTSFPLQMILIGSVSKEWIPAASTGSHLLLLSMHYQLGPLVSMAAAGQFCASRWGWPALYYFQSVVTFIILALFWQFYTEMPENNHSTTSTELALIRKCNDGEGLAKSAKVSDKKTLGCQKVPYARILTDGLVWLVFVAFFTGELGMQTFVLYGPTFLNKTSISASITFLVALVVKSLASPLNTFISSFMSESQRVKLFVFMPQSIQICCFVSLALLPKILLSTLTIPIWLVQILYTSVVAFAGLDFLGVVRCAQMISQSFSHILMNWISAINSLILLLLPIFVTFAVPNQNVEEWARVFVGIAILLVFSMAIFLLFGNSLPRRWTKAEVAEEKRKRPAKDCVQPVEMSIVIDSTEITSMRNYPENLVQSEKELHELAQFTIEWAHNNGLILRASKYYHTSDIAQFAPISLFPSPFPHQAFDQIVAVHTAMQLLYFRVGNDLDFLLNAYNDVIETDEHIRAMVNIVREAHEEGIKQPITLLIMRADYMMNSLKNSENDSEQQQQQQQLEVKQVEVNTGAIVALGIDHRTTELHRQVLKKFGLNTSNSPDNVGDTNLAESMFMAWKAFGNSKALMVFLTIPNFLYKFDLHQLACELKRLSKDQMDIEYVSLKGGQTQLKLGDDFSLLLNGKIVGVIYSCISALGYVITAESMEVRRTIERSTAIKAPSLAHAISSSKKVQQLLAMPGTVERFFPDPADADKVAAIRETFAGLWGLENNDDKTERLIEDAIEHPEKYVLKPNRECGGNNFYDEKLADKLRDLPQNERASYILMQKLYPTTFKNYFLRPFNEPKLSTVVGEMGIYGTLIGNKLDGSVQHNVQSGHLLRTKLAGVNEGGISVGTGVGDSPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1L0</accession>
    <name>A0A914H1L0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1282.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1282.t2"/>
        <property type="gene ID" value="Gr19_v10_g1282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14211">
        <property type="entry name" value="STKc_HIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000029">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="587"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="534"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1388"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1388"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1410"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1430"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1282.t2"/>
        </source>
    </evidence>
    <sequence length="1548" mass="166846" checksum="EC84D3D62263D847" modified="2023-02-22" version="1">MDSTTKMPIVGSTVVVGGNEMPWREETNAEHCFEGAIPSHSSPSLQRHRPSLTFPPHFPSAFAQLNNATISIDDERKRRNRRERLPSFTQQQSQPLTEAVLLLFSNINRPTRTTPTTKSTPNPLIAANFFHFIPKRTQFSENGQKQVHHPPPPSFGLFIVYNNNIIVSTEVLAVQVSAVIINSRIPYRHQRMQNSQEQQQQRHQQHHHQQQQKQRKRKFEAAADGEDFSARAESVATTKKIVAVEQPQLNPAAPTRTTRSSNRIANQYAHNPSPHPSPSAYQQQQTYGGFQRHQQQRGRGQRKSGGKNQQQIVGEAAEASAVGVKRRQTSATKQRPREGAFQQAEDPADTPPSLSLIASNSGGSTRRPAFIKIEEENSLTSAPSSLSAAATLSANSTHGRQQRVVAAPKAVAVANCCLRTRPPRTTRRHPSSNKSLRDIEISAAAGNGMFGGAILGPSAGGVFSVVGNSSATAALYHQQQQQHLTGNGATSTTNGGVGTFLVKNGGGAHHRAVPHHHNNSNNHHHNFVQPTTTALLKPMGGGQMQTSQQGQTKQQHQSGHHKSRQSTEGEYQLIKNEVLSSSYGNQYEVLEFLGKGTFGQVVKAWKKGTNEIVAIKILKKHPSYARQGQIEVSILSRLSNENAEEFNFVRAYECFQHKSHTCLVFEMLEQNLYDFLKQNKFTPLPLSSIRPIVQQVLTALLKLKQLELIHADLKPENIMLVDPVNQPFRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFREAIDMWSLGCVIAELFLGWPLYPGSSEYDQIRFIVQTQGLPPQQMLAEAAKTHRFFKMIKDMASYWRLKSMEEYELEMSTKSKETRRYVFNCLDDIAQVHIPTDLDDIDRMCERCDRQEFVDILKQMLSMDQDRRLTPAGGLQHKFVKMSHMIEMGRTKYCQMAAQRMEVCYRFGLATAASASANNTGAVAYGRASVTGGSAVAPGPSGGTAVAGGQAPPLMAAPLIAAAANAAAVAAAAQPPNQQRAAAVQPQAAAALALSAADFSHLFQHYQSAIGQLQPVVGSAAAAVAANQAAAQIAAVAAAAPYVCQPLTAAATVLPYGSNRHQPPPQFATVAAAASQAQSISQFVPTAAHQFVDPLLAAATGAANAAVAAAAHQQQQQNNPNCSGATGQSAGGTATVASHVPSAAGPSHGWPPHTVLQGTTNATAQNSAATLAHVAVSNANANTTAALFPWAIAAAAQQAALLPGGNNPAGAAVSDFFLPANAAAAAALQRQMATAAAALQFPHFFSAPVQAAAQQTAKNYSQQLQLLAQMQQQQQQEEWAAQLLNGVRPLNAQQQQMLQQQQHQAMFARLKNEAAILMQNSLAEHYLLDRSNLEHQLKQQRRWCVVAERFRQQQRGSQQQQRQQQQNAVGAGGGTSSMSMSARKSSNARCAVVRPQQQQPSQQQQSYQQMLLQQQAEQQFLAAGGNSASGGGVGNPFEMATAAGLDSCYAPVALQAAAAAAAAANRSNVTAPNPAMLAHMLDLTNASLYAELGAGGGAGGSAASGAAYTNQHYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2A4</accession>
    <name>A0A914H2A4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2A4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12577.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12577.t1"/>
        <property type="gene ID" value="Gr19_v10_g12577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12577.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9735" checksum="327EEA352A5A19A4" modified="2023-02-22" version="1">MLNKHLYPTIWHFINVLRAEQKSRDADFARFVMGEEPPKKAEKFRRADAQILRLVERYDPLNIVEMLRGISRCYVMDPEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2L9</accession>
    <name>A0A914H2L9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2L9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12665.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12665.t1"/>
        <property type="gene ID" value="Gr19_v10_g12665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12665.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="25337" checksum="F552BAE372B56A8F" modified="2023-02-22" version="1">MSYWQTCLNRVKSRGELEKGSIGKTKKPTDPIRVAKSEIKSAELSIWQKRSEEIPPEGKQINQLDCSMNTEREENREKFESGKANRSDEKNIFMEEKKSKEAQEITALLLNLREKSLEIHDEAEKIMRKVEKAFEMEEKREKRGALWQQHDVRWPVFERNNRRGSGNWNESRGGWSNQRGARGWRRGRGQWHDRNEWGPSTSQQAEDFSKMADWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2U8</accession>
    <name>A0A914H2U8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable methyltransferase required to silence rDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914H2U8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13355.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13355.t1"/>
        <property type="gene ID" value="Gr19_v10_g13355"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g13357.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13357.t1"/>
        <property type="gene ID" value="Gr19_v10_g13357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046015">
        <property type="term" value="P:regulation of transcription by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13355.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13357.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37474" checksum="627196B4750D306A" modified="2023-02-22" version="1">MSFSESESISKKSTIRKVKEKVPEGKEKSESVGKRPWRQAVRHRAKRKRKAAEEETENTGSVIGSGCSTKKRKRNNKLGKKKRAKKRRQLNGDKEEEVGQSDAFPVDWGDNSPLTSMDASRFRFLNEQLCSQTSATSAELFQKDPDSFRLYHRGYKHQLSKWPVNPLDKIVLELGFLPPESVVADLGCGEAEIAKRMGGRFQVHSFDLVASNERVSVADMAELPLESESVDVCVYCLSLMGTNLAQFFREAHRVLKMHGKIKIAEITSRFRSFSTFMSAVQKMGFQMKRKKLISDGFFVMLTLEKVVEKITNKRPKDLRLKPFLYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2X1</accession>
    <name>A0A914H2X1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2X1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13160.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13160.t1"/>
        <property type="gene ID" value="Gr19_v10_g13160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028092">
        <property type="entry name" value="RD3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14473">
        <property type="entry name" value="RD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13160.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20132" checksum="ED2EE974EEC0F5DB" modified="2023-02-22" version="1">MAWFESRLLRSARPFVPGGGGPCRDGMMCDLVLGEIQAEISKAEKETERRRQEELRLTNRPDYSWLVDWRLRAKRPLGFRESSEEWRTRVRFVESRDEVLDTFRTVVDELATERMRRECLVMSVDEQLEENQMKLPTMAQTKQKQRPKSARTGHYPAQLSVFALTLPDEGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H412</accession>
    <name>A0A914H412_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H412"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13059.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13059.t1"/>
        <property type="gene ID" value="Gr19_v10_g13059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13059.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29014" checksum="B6781BD564F2F5C0" modified="2023-02-22" version="1">MNIDSEVVFCPNKMEEFWILILVLFFATNSLDKAESVQLEELEELPLQTFDELFVDEWLDKDEAEDLKTPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQNPSLTKSYNSDNSKNGEEITSNEKQKFYQMKAMLKRAGFKNSYTKQIDKTVAKELGLSLATIYNWKSEFGQSRPNKYSHSEKKELLKLYYEIKDKNPNINDKKIVKMLKIGIATLYKWKKQFKLQQIHANSVDGHEENAGSNVQEIGHSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H585</accession>
    <name>A0A914H585_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H585"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14277.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14277.t1"/>
        <property type="gene ID" value="Gr19_v10_g14277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14277.t1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37500" checksum="1EA53EB8B89F1AE5" modified="2023-02-22" version="1">MHLIELFDTGNTLRYNENIMIMELGFETFHERLYKRIDSYENDEEMKNIICALTVPIKEIHQVAIHVNINPQNYLYVSENGTMLLKLKDFGNAKLIHSDDNNESYLFEVDALDAFASFRAEYTGPEHYEQDKEISTKFDIWSLGMIIIEIHIDRLRFKQGKDSLNEQNRGVFLRELGNLYLGFERNHTGRFIVLELWLKFQKTALLVTNLLHNQRTLRLTAQGILNYLDDSCFLEELMPIKNAKDLRIFNTLNFGDFKRMVAQKMRVNRLNIWKSDHREMKSEYAQMIASLKAIIGVQQQNIESMDAQRQLFEICEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5S3</accession>
    <name>A0A914H5S3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Magnesium transporter NIPA2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5S3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13934.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13934.t1"/>
        <property type="gene ID" value="Gr19_v10_g13934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13934.t1"/>
        </source>
    </evidence>
    <sequence length="380" mass="41606" checksum="70DFEEC9336E39C1" modified="2023-02-22" version="1">MESQERDRSFISSEIVGRLMSLQNSSSMEMYKLHKSLPTVNSSSSSQLPLHFGPMGVDQSASFDLTSPYPYVRNGASLVDFYIGLGLAISSSLFIEGGYGYLKEWLWWMGVITMGIGEACNFAAYAFAPASLVTPMGALSVLVTAVLSSKLLKERLNLLGKIGCAICLLGSTSIVIHSPKEEEVSSMAELAEKMKASVFILYVALVLLVTFVLVVYVAPRYGHTNILVYIAVCSLVGSLSVISVKGLGLAIKESITTEEQFTNWLTWFWLLAVLGCISVQLVYLNKSLDIYNTSMVTPIYYVFFTSFVILASSILYKEWACLGASDVIGNVIGFLTTVIGIFQMQLFRDIEIGSLKRFRLLCTTDSRSTTSSHISGLDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6C7</accession>
    <name>A0A914H6C7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Skp1-related protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H6C7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13641.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13641.t1"/>
        <property type="gene ID" value="Gr19_v10_g13641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component dimerisation" evidence="2">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13641.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16842" checksum="CD572040385D7367" modified="2023-02-22" version="1">MTPLCGDSEMEFPILTNLSVDTFNKVVAWMKHRAGKDEPKVETDPNTHELKWFELDDFETKFFEQLGVKELASVMNASFYLQIESLSLYACQSMAAVLKDKTVEELRQLLNIPEEDWLSEEQMAEIRTKNACEDAIGVGMGAKRCLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6F8</accession>
    <name>A0A914H6F8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6F8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14442.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14442.t1"/>
        <property type="gene ID" value="Gr19_v10_g14442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14442.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19915" checksum="9CD3CB50C2D5FDCC" modified="2023-02-22" version="1">MNRLKRANKWSEAEFERIKAQSAKAKSVIDKLMKEKKISKEDYDIVYRPPHTSSVYPSNAVGAYQFIRKTLAPLVKEHKLENVPFSPKVQDFLALQLLQRRGFDDFLSGKVTLEEFARNLSMEWASIPRSADGLSYYHADGKNVARVPWSKLLDMLKEAKSPSELCGHSDDLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H6T1</accession>
    <name>A0A914H6T1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H6T1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14545.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14545.t1"/>
        <property type="gene ID" value="Gr19_v10_g14545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15898">
        <property type="entry name" value="EFh_PI-PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="262"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14545.t1"/>
        </source>
    </evidence>
    <sequence length="427" mass="46874" checksum="484074C2B5E10573" modified="2023-02-22" version="1">MRGATAGNRLGQARRSRDAQLMAAAASARISRRHSHQRAFRRVLPPPPPSTLLQCSRDHQQQTNPHLDPHPPDAPVEPVIALGVCVRSVGVFKSALTLTAVTQTTAATVPFAATVQPSPHHYRIPLAGSENCLVGTATVLQHQQQTSGTSVESTSVVGNTITTVPAAGIATTKMHRQYTGSSAGDDDLTVEEIQEFATAFRMFDKDGNGTMSIKELGVAMRTLGLNPTEDELLNMVNEYDVDGNGIDFFEFCKMMKEMNKETDQELIRLAFRVFDKDGNGYITAQEFRHFMTTMGEKFSEEEVDEIIKEFDKDGDEQIDYEEFVNAVAPIVNDGAKEDAPWVQEASSTAVPPPTLVAAALPLACPFQTFIIHLKKEPPKKQQRQPEGQEHQAPRLRVVVQAVVTLAAPAGADHLPHIVPQQRLERRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H709</accession>
    <name>A0A914H709_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H709"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14413.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14413.t1"/>
        <property type="gene ID" value="Gr19_v10_g14413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14413.t1"/>
        </source>
    </evidence>
    <sequence length="400" mass="46251" checksum="76946486558C66BB" modified="2023-02-22" version="1">MKGRVRLTNSEPIAEQVVGETAGRRSTLQLCAIPPSSTNLETHWNYKNILELPTTKRMSDNPKEAAKEMENIFVCDDVLFDVFKFCGHFVLGLKVALISDRFDRLVDAHFKTKEWSLGFLEIRRARDGNGTEIVKLSDWRGKERHLPIAQIPLPNNVIGFEHIRISYFDQSVVEFLQSIRRLFDSSGTNLFAEIADDQTRTWEKIGQEIWPLISDKICVLELDAYDLDRLHQFSSTFLSNCAKLRKIQSVYSVLEFPADGSANASFEQALTEWLHTPRGDGLPKLLQCNYCPIGMEGLKRAFLNAADPLSFIIKIWFRNSDDIVPFELLNNLTGERLVWLKKNFRLLVRCPIERDEDKWAKWEKEAYDFYYEWNRISIEFNDSGIDDGAFDQFDNGDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7D2</accession>
    <name>A0A914H7D2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7D2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g139.t1">
        <property type="protein sequence ID" value="Gr19_v10_g139.t1"/>
        <property type="gene ID" value="Gr19_v10_g139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g139.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45472" checksum="8013F4F75C80D3DB" modified="2023-02-22" version="1">MTVEEEEEMEEVEDGKKEEEEEEWKEDGRRGKGGRIGDVGGFENSKRNEDFNYVPDFVEEDAADSYNNANAIINNNAKNGNFYNANGQQIIGQNEWQRKQRILRVKTDEKFTLKYQINTEEGQVIVDYINKARAVIARGEATNLPIASGMNQIKWKRSLASEAVKLLGTNQNRPVNILDLEVVHLIAGGYGQGTDASDYGTQQNGDDEQQSGGYGYRNRDYEYFSSLDKNFIELKATDVLLMTVKNYLEMFMGQKGLNCDVNSCKATCKVPKRNREVPIKREDENPSEYFCYPYELIYDHTHSIGCAVHFETKRKTELRGKLVCIMSTQHGHKKMLHHHNVFKVGSSCSNCERNFTCNAKSRLCVKRDEERRRPPNVRGAQRRQNAGSNYASALPVTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7E8</accession>
    <name>A0A914H7E8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7E8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14897.t2">
        <property type="protein sequence ID" value="Gr19_v10_g14897.t2"/>
        <property type="gene ID" value="Gr19_v10_g14897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14897.t2"/>
        </source>
    </evidence>
    <sequence length="102" mass="11863" checksum="64255CD232127CBA" modified="2023-02-22" version="1">MAYGRLGRPFNVNVAAHFYVRHRIKLLHPFLHCVVERFPEGQEDRFYPLELCKIEGEEMKLPDWLGNVFSAVRNNNNRDDTEEGGRAECSQTSDNSSSYSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7W2</accession>
    <name>A0A914H7W2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7W2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15022.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15022.t2"/>
        <property type="gene ID" value="Gr19_v10_g15022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037631796" evidence="2">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15022.t2"/>
        </source>
    </evidence>
    <sequence length="152" mass="17881" checksum="10C36A222F417AA1" modified="2023-02-22" version="1">MEKLWILILVAFFATNSLDKAESVQLEELEELPLQTFDELFVEEWWDKDEAEDFKLPAPTNFGRNVHHQIDRQNTQIGQIEPNSTDQNPPLTESDHSDNANSSVSKDERKRKIIDKFHAIKDELKQKGKYSSKERTQIRWKRELGQTTNKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H800</accession>
    <name>A0A914H800_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H800"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14659.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14659.t1"/>
        <property type="gene ID" value="Gr19_v10_g14659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037779270" evidence="1">
        <location>
            <begin position="17"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14659.t1"/>
        </source>
    </evidence>
    <sequence length="977" mass="106793" checksum="4B9E4B61071D181E" modified="2023-02-22" version="1">MIGMCRPLLILMGCLSVLILTHVPKPVLVTMEPGNETFTRPQLDAGPKLRNFYGSKMAPEPRNETLCNATSPPELGTDSINGTQTAGLEALDGFTAVPGLQAVNGFQTVVTGLEALNSFKTPLELGFETATGNGNEPASSGAELGLTTPDAFVLYTPISFDHLVLPTIASLSAFVGKDGPTVLRMYWPLFTLLGTLNVAEAGVTLPAYGGVSFSVPDQMVMEAACEWDLLDFSVLGQVVQVFTDAKVGSAYALLHCAKHGCNWGYKYRCCEEPKPEQQQWLDACEAAAKECPCGWFSCLPTPGVPLTKCCAAGYNFTCCKKPPPPPPPSVAQLDHEKNCTAAKENCSCKWASCIEKKGEGASPCCAANYVFTCCVEAILQMELCKKAFDKACDCHWGSCIKQEGIGATDCCAANYNFTCCQHMLPMQQQQMSECRKAYEECKPCGWANCIPDAGTAATPCCAANYAFKCCTEKPPQTTPIPRQLEELEQCEKARKKCPYRMSKCVPKRGQPAGTCCTSDHIFTCLKPSFVWDKKTALELLQIFQKKRECKGKKSFCICEGPYFAQNRAGFGSDVPHRLTGTCCDDSSECQCCWTDEAIVRLPTLHNVADTNECKTMIAEEEKCTCAHAHHPDYSNLVPHSCVKEEVWPESPCCEEGYRFECCAYPEMDVQNQVARVLCDAKDPKSNDCTAIGHYATSEFDCDHAPEINSICYFNFLVARKVIKPTAITQKPVLTLCKGRAKECPCGHASCVFTGVVPVQIEACCDGLYEFKCCAEETGLTTATANEKLDSKPTATALTTTTENPSGIYEKGKCKERTEIKKICKTCDFYSCIRREGYASSICCAEHYDMTCCVGEQVPTSTTKFTTMQTTLSTEMTTTMAKTTTMSEISTNPKTKKTSTTVEDPIYAERNAAGPPMQCLIKAVCTKTTNTKPSYRFKIDACDAVLEKIKKGEDERINALGLEFLEGQGPIQLKEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9P1</accession>
    <name>A0A914H9P1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H9P1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15505.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15505.t1"/>
        <property type="gene ID" value="Gr19_v10_g15505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002484">
        <property type="entry name" value="Protein CBR-LSY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15505.t1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42622" checksum="E6EE4D8BE3F0B02E" modified="2023-02-22" version="1">MDQNHDYLAYQNVTHEEEEEEEEEETLMDHHTDESSDRKNSMVLQAYSVIESEESMLDPHIKPKAVHQCPVCNKIFVSLKGLQQHAIIHTDQKPFECDICRKSFRFKSNLFEHRSVHTGTTPHRCPLCGKTCRLKGNLKKHLRTHCTTKEELEAAWQPFASNRRAPAEIPQDAIIIRATADPTALFAPLNKPKKPRKLGLGSDVAFWLDKIKRCELLPPVQISDKMRRLADLIKMVEDGGLDMEGLYHHASAIPFERFECPVCKTMFFSRVECSEHMESDHPNARKQRPHFCELCLRSFVDRQQLTTHQEHHKRIQSMLQNDELKVTEPQIMMPVLEQEMARDDVEEDAEDGNTEHHHHQQMVDGLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9T2</accession>
    <name>A0A914H9T2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9T2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15122.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15122.t2"/>
        <property type="gene ID" value="Gr19_v10_g15122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="256"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15122.t2"/>
        </source>
    </evidence>
    <sequence length="403" mass="44635" checksum="608CF8C223BBF9C1" modified="2023-02-22" version="1">MKRLLHTGIGADVHFLVGEEDKKELLPAHKAILMAASDVFETMFRFDAKNAKATAGGTAPSEVAKPVEVPDVEVGAFKAMLSFIYADDVSGLNGDNAMAVLYAANKYNVSGLIKACVDFPKAKLRNVLVALGEARYLQRELLDRDQLFVCGEIAIWNAALRWADEKCRQNGEKCSSENRRKMLGPAFSKIRFPLMPQKDFSEIIVPSGVLTNDQMMSVYLHHSHPDAALPELYPLQFPTKRRTATKSAGDDPYKANGNILLTIEKVSEFARGHDKNSSGRRFSDAVYIRGLPWKIYAIPPTVSAQKHLGFFLQCNSDSGNLADANWSCTASSTFRIVSQKEGKTDHTREETSDIFNSEAKSWGFAQFMSFEKLMDPENGWYDATNDTAILAVDVTAEEPFGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA17</accession>
    <name>A0A914HA17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HA17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15429.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15429.t1"/>
        <property type="gene ID" value="Gr19_v10_g15429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="285"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15429.t1"/>
        </source>
    </evidence>
    <sequence length="428" mass="47885" checksum="54228A0C3D46B517" modified="2023-02-22" version="1">MKRLLGTGDGADVHFLVGEGAEQELLPAHKAILTAASDVFKAMFRFDAENAKSAAAAAGTVKPVMITDVGVDAFKVMLAFIYADDLRGLNGDNAISVLYAANKYDVAGLVEACVDFPKEKLPNIFLALAEARFLGEEDFVRRCLEHIDGNADTLLRSKEFLEIDQKMLCEILGRDQLFVCGEIAIWNAALCWADEKCRQRGENCSAGNRRAMLGPALFKIRFPLMPLKDFAKIVPSAVLTRNQMMGVFLHHCDPEAALPEQYPLQFPTNQRTASKPDDNDPNKAKGKIVLKIEKVSEFAQGDGNSFQLSEAMYIRGIPWKILVDCELCPNLQEKYLGFYIRLNDENTEDTNWSCAASATFRIVSQKEGKKDDTQELSRHIFSSNYSWGFEQFMSFEELMDPNNGWYDETNDTMILEADVTADEPHEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HA70</accession>
    <name>A0A914HA70_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HA70"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14694.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14694.t1"/>
        <property type="gene ID" value="Gr19_v10_g14694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057001">
        <property type="entry name" value="RYYR-CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23674">
        <property type="entry name" value="RYYR-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="116"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RYYR-CCHC" evidence="3">
        <location>
            <begin position="460"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14694.t1"/>
        </source>
    </evidence>
    <sequence length="900" mass="99817" checksum="28A605102AB83B17" modified="2023-02-22" version="1">MENNAFGAGGSKTNRHHQHQLWRQTGDKVEHENRSTHNNGKKGVLVAAHTSQYDDADVPCTSAQALQHDHHRQQQLLVETFLDGRLRLLSSTSTDESASANAVGGLERMSADVLVNFCASDILSGDETFLRVHELAGTELKDFCAHYQCMGIGNCRLSDAFGLTNFKKIAHTILPRAVQGDLIDLDELVEFDLTLCYRNALDLTVQADQRSILFTHPMLYGDRYGVAKLAVAVIVHWLDNSPISHKLDFVGIACPSADIVQCYVELLAELLQHGWADFVASHSSALFSVLVDAFDTDNKFDSIGAIKAAMTSQQDPALRVHLVGTDSRRPRRGRPKQLAEYDTGMATMLDMQGLDTLFEREFPSSDAALSAQQQIDDAEAQIVGEMAQPLRRKGFKRPYDEMDETLDAVAAVPPQMPPFAEHHVNLNRFCVERYGFDEQYIRAHPDKVYGMLFHSSERLELQLSRNLSATILSIECEEPENKGMIRQYRMTTQNREGDTLYFRCSRCESLMRYTNDEYRPKLTCYPVNKEWVIIQQLDRQSRLYMLQLDAMTQWGMSSTEFGSTYMDNDGTPAMDQNGGDEAAAEFRGPAETAEWSQIAPKFARTSFNNRAQKRTVVATDAQQRVSAHGGGALTATVKQELCAVEQQLPPTTSSARRLRPIDEGEDDMEYKFASKISARKAHNQPILVATPRYAFNAPSDAIGEVPPGMCMLRRAEAQECTTLRAIRNCENELEGRVGTELANALAKEERMLWTFSAGASRFRGAGPLSSAPLHVPHQNFRVAPEHEEVLVDEVVEGNGIKMELLESHGMDSVNGNGGESHDHGGQPMPEGGSVVPKSMAAAAAAASSEAMLIDRKEFGGVDGSTTAAAGAAKFRKYRVIRKRGGPNMAFDWRETELDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBA3</accession>
    <name>A0A914HBA3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBA3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1552.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1552.t1"/>
        <property type="gene ID" value="Gr19_v10_g1552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF8">
        <property type="entry name" value="FORMIN-HOMOLOGY AND ZINC FINGER DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="626"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1552.t1"/>
        </source>
    </evidence>
    <sequence length="994" mass="110238" checksum="8DEFCBF5073C4614" modified="2023-02-22" version="1">MAHFVDLSKDANRRNSQSVNRRHSLIITKVTGRRRRRSERRRSRIANSEKDARGGGGRWPRRGSVPAFILRSSNANANASSSSFRLLFTSDKRDFAFASSCPDDGTSPDNNASFFLILLLVSSLFLSFLNSEFVRLIRTNRQRDEIVSQQPQTLKTNSSTMAMDELTALSLSLNGGQQPQTPATIEKLLQISRQFLSGRNEISGDGMGKKNAQKRAMAVGIGNGETSPRGEESNGTERDGTAKGGGGGARGGNGDGRKRSYPYTFQFCVLCQKNVHSSKLPCHIRQCHVGKPMFQCPVCDFTSTYSKNNVKSHMVSLHGLAGDPISYMDQYASQVEEFMKQCFPNVRGRGRPLHGRLSPARVKQTVAANDSRSLVVTISPPTMSQSQQRRLSPATANAGPSSSQQRSGGRQQRTTTTNTQQQQQMADDQPMMVVGRAEAHHHPLLNGNNVDGGALLPFDATDVYGAAMGMLKTTTGNRTPTSLVPNKDCCSDPSLSNFGKGAAFGPLPQRDCGFLSAFNPFIYLQQLNNLFALNAVNPNGHQQQMPAEVKMETELDMPVDEDALHQQQHRLNASSMFSLEECLNLSQKFLKEMSKCEEPANIANCEANDVKSDASKELLICHSSSSNTSPHPSGCFPTNSSASVGAVLREEVPLYFPHQLNLTVLDGPVLEKTVFKTFANSGELIEKFDLSVFEPFLDQNSGSLLSPTQHQNVTSVRKQLGLKSFEIMFAVHRLDIDVLKPENVHLVMQIAPTDLDIRRFRLFEQSNSLNSLDEDEQFVVQLSKIDRLREKISVMALMGEFDQRVAQLNKHLLAHSVAAKLLFNSAEFHTILHVLLTCVNLVNGDFASQLVKGFRLLRLPEMCSFRFPDGSTLLKVLAQILRRHFPDDLDTFLKRTKVVEEAAKVEFAHFLRELRCLERGQSLVEEELQLCHGKNPQLANFLTHCELECAQLRECIQNTNCQVLSTMEFFGECTDEALGRAVIAQFARDLRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBS9</accession>
    <name>A0A914HBS9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Clusterin-associated protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLUAP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBS9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15153.t3">
        <property type="protein sequence ID" value="Gr19_v10_g15153.t3"/>
        <property type="gene ID" value="Gr19_v10_g15153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019366">
        <property type="entry name" value="Clusterin-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547">
        <property type="entry name" value="CLUSTERIN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547:SF0">
        <property type="entry name" value="CLUSTERIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10234">
        <property type="entry name" value="Cluap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="215"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15153.t3"/>
        </source>
    </evidence>
    <sequence length="479" mass="54087" checksum="79083FD6035F8F2C" modified="2023-02-22" version="1">MHKSCLATKQTKSIQRDVGKCRTKVVMSFRELRDATEILRSLGYPRLVSIENFRTPNFPLISEVLAWTVQKFDSNARLPRQLDNEADRVLFIKGVVLALLQKAHVRLNPKHLYQSDGHAIRELLPVLRMLYESVRERRHKGGGEGTAEGGGEAVHINALRSQVNAKRQQLHQTVKLAAELPKTGANLYELLKDEVFAKDVRTKALGRSLNAVQVEAELRDRIQTTEQHIDEVKERLQNIESDEQELSRKIERRKRELDQLQKRLAKLQAFRPPYLDEYERYEAQLRVRYAAYVTLFRNLHALQSQLALSEHTERERALEAEASMRVTVEKMRMESEQTAPVIAGIPLNIGERPVDGLEADEQMDTEGHGRQRPGGEVRVFGNMVGLGLSDDEDEDDDDGGRIIEMDDDQDEDDDDDLVDNFISKHSTSTADVANINKHGDLQKGGKTQAGGAGTHHGDTEDEAETEDGDDGEDNSGDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC81</accession>
    <name>A0A914HC81_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aryl hydrocarbon receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HC81"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15763.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15763.t1"/>
        <property type="gene ID" value="Gr19_v10_g15763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034751">
        <property type="term" value="C:aryl hydrocarbon receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19696">
        <property type="entry name" value="bHLH-PAS_AhR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039091">
        <property type="entry name" value="AHR/AHRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF12">
        <property type="entry name" value="SPINELESS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="51"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="154"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="845"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="858"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15763.t1"/>
        </source>
    </evidence>
    <sequence length="971" mass="106095" checksum="9BF5F64193E37B16" modified="2023-02-22" version="1">MYASKRRQRNFKRTRTVPLGEIGAKCSQDIGQFAEILLQGHGGHHQQHQHSGNVLPSNPSKRHRERLNGELETVASLLPYEESLLQRLDKLSVLRLAVSFLQIKAHFQVCAQQALESAVGCCAEHPLARLHGSPVIPVPTMVNPQTGMASLYFGDTQFAELTQKAMGAFLLMLHLDGDVFYVTENIETKLGFQQSDVLHQSLFEMIHSEDREELRALLQRALEVVSRRDGGGGEGAFSDQAASSDGGWSVSVVLRFRCLLDNSCGFSRIELRCRLISVHSHRVELSPFVPPQRRTRTPTAHQYPPGLDSAQFGIGTSALANSRKYALVAICTPLVPPPQMDPELDDPILKSRHSLDLGFQCMDLRLRHILELDESPSPSLGASTSADPPKPSLYSFVHPDDLRTVAEAHDAAIKYTASGLMIYRLVSANSQFIYFVQSSFRLGQKNGKLDRIDGSHRIITEIDGESLLEKRSTPKFKHFTFDDTLLQSPRMCQSNQQQQQFVVAQQPLQQMDSIGTVDTETRAAASFSPTDCSNLLRDAPTTAKSKKGKKAGKKEANNGDGAADGRRGAVAKSPAGAVPTALTPLFPSAPSAITSTARCLASSQLQHSLQPSSNLSSLPGSACLHQQHHQPPPPPPPSDSVMADNDHLLHSYFAWPNPVGMLASPSHNANATSRLKRFTFERYYAESVDVSPYGCYYYCPSSSSAAGTFTHNNPSSLVDFVPGSANVYPPATGMDYWNSMLAMAAGPATGVTDAYATLQQQQQQQFQQLTLNQSSLIAADPSAQVAAQFQQQFSPAWLNAAGSVFNFAAAASQIWPSPPFPAVDFEHSLASYPHNQIVAHLATAEDASTEEEMAPIDQHQQQQHEQQQQQQQQQHHFGERWTIDKRSGRKHSDRRRDGGANEVIGKRPFAFELADSVGTAPAIGEKNAAPSQLTTIPAQTTAGFLHNSVANATPNASGFRFLTEMAQTLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC88</accession>
    <name>A0A914HC88_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NadR/Ttd14 AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC88"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15729.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15729.t1"/>
        <property type="gene ID" value="Gr19_v10_g15729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053227">
        <property type="entry name" value="TRPL-trafficking_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932:SF1">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15729.t1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46080" checksum="B1FBA0DFA4253B62" modified="2023-02-22" version="1">MGDKKQIFKIVLTGGPCAGKTTGQARLSSFFESIGWKVYTVPETASILLGPGRIRFQDLNRTQAAQFQIDLLKTLVQIENVFFNQAELSDSEKIMIILDRGAMDGSAYIDVQSWTDVLTSCKLDVHELRERYHQICHLVTAADGAPSFYQLANNQARTEAVDDAIVIDKKTREAWVGHQCLSIVDNSNCRTFDEKMSKLIAVVCERLGIPIADRLAPNSKKRKWLVRKITENESFLRVKREKFSLQHDYLNTTGSSQVRLRSRSQNGKCTYTLTTRTFEDSDGKKLPQPVETRKQLDKREYQRYMGMRDRSRQPIHKERVCFLYGNVYFNLDIYIPPLPPALRDCGKQLMILETYTTRASGDPEPCLPDFFDFEREITDESAYSMYNLARNDCKDAMNGVLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDQ1</accession>
    <name>A0A914HDQ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDQ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16071.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16071.t1"/>
        <property type="gene ID" value="Gr19_v10_g16071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16071.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11391" checksum="CF205759024D2B33" modified="2023-02-22" version="1">MINGRCDHSKFVSPNIHPSPMKAILISTVWWSRPSCLFLDDRAALNVFIDGEDMTNGMEVGRHDSTNRQRPRPNDVMCLVFVLQCGGCTTDEADIAPRAETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE94</accession>
    <name>A0A914HE94_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proline dehydrogenase</fullName>
            <ecNumber evidence="6">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914HE94"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16549.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16549.t2"/>
        <property type="gene ID" value="Gr19_v10_g16549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="397"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16549.t2"/>
        </source>
    </evidence>
    <sequence length="646" mass="73675" checksum="B46116B4105BA6C0" modified="2023-02-22" version="1">MFEQKKRAPIRSRPTRSLFQSNHLSDLSLVVVSSHLHNVSISQIIWFYHRMANLLCRWSYSLRSPSIAPQYTSHYHQRRQQQQSFASVSKQSLSSSSAGEASQPPPSALLKKSPEQLRAESELCYQRLDLTFQNAKEAFKSKTNFELLRAQLVFACCQVNWMVQHNQKMMRVARVLLGKRLFNALMRSTFYGHFVAGENIDEVSETVAELQRFGVKSILDYSVEADISEEEAKEKAVEGIDEDKTEQIPPALDVLASSVLPHHEAQLEDTLGDQSVADLVDQTQKQFSVHKEFGDRREHVVSARTYFYSGESECDRNAEIFCNCIDATAHATMGQGFTAIKLTALGRPRLLMRLTQAIAQMENLFRVLTGSSWENLCLSRICEDELIDRLQEFGIKSDQKAIREWFKHADFNEDGFVDFFDWGRLLDVEAGKLQKVFQVLNINTGKLEPVLNNLTERESLELSNMMGRLTKIADHAVSRGVRLMVDAEQTYFQLAISRLTVALMRRYNHERGFVLNTYQAYLNNTLASLTIDMQLARQENFHFGCKLVRGAYMDQERLRAAAIGYEDPIQPSHQATSDNYHQCLDAIVGEWAQRGRNTVSVMAATHNVDSVRYAVELMRQRGIAPSERVICFGQLYGMCDWVGFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HED4</accession>
    <name>A0A914HED4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HED4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16581.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16581.t1"/>
        <property type="gene ID" value="Gr19_v10_g16581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16581.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="27619" checksum="9ECF9E7E41A03AF2" modified="2023-02-22" version="1">METRKRPKPPERIEMECKIPEEAGRETNLKKPEETKTQKILVSEKMETKKRPEKPERMEMECKIPEEAGRETNQKKPEEIKTEMILGPEKMETKKRPEKPERMEMECKITEEAGRETNLKKPEETKTQKILVSEKMETKKRPEKPERMEMECKIPEEAGRETNQKKPEEIKTEMILGPEKMETKKRPEKPERMEMECKIPEETGRVTNLKKPEETKTEMILVPEKMEMKKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEU0</accession>
    <name>A0A914HEU0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEU0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16488.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16488.t1"/>
        <property type="gene ID" value="Gr19_v10_g16488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16488.t1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47503" checksum="64D3535CAB395C7A" modified="2023-02-22" version="1">MADFWTESIVADLIAELEKDKQHARLDWLAANSPLVNRFQEDIARLSEETTNSSSSNRRSDVYKYNRSDELDRLFEKDRDSKAMRELNVRHFLINRVLDEFRPNIRRLSALTIERTIATFCVNQRKEVEQHTLDVYDFLMDCVEHQPPLTAEHRWFWMCVVTSMHADHNDDGQVRDNVRTFGDKCCTFFKNDIRSHEYKLFLLTLLEYDYAATVARQRHRIESSGCGSGDAKSKAPRATVVLSTTSSTSSTASSSSSSAAAAAAAQKRNLPLNSMADLDTFPLVYLMMCRVHNDSANFSEQANNKLYALILDVLLSFNPRNPKQHIRVSRLYARLVGLLLDVLLFVELGADPYHQITKPGQITDKLSVLLRKVRKQNDDMEWSIFVDLADVPWIKEFAPITESPKKHKHAKGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEZ8</accession>
    <name>A0A914HEZ8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914HEZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16534.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16534.t1"/>
        <property type="gene ID" value="Gr19_v10_g16534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000061">
        <property type="entry name" value="Poly(A) RNA polymerase gld-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="16">
        <location>
            <begin position="507"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="15">
        <location>
            <begin position="740"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="301"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16534.t1"/>
        </source>
    </evidence>
    <sequence length="912" mass="102251" checksum="52A95BEFAA829BED" modified="2023-02-22" version="1">MAAPLTNNSNTEQQHHQQTNHPQQQQGLSSSSSSGSTTDNSVSFQVPTLLVPQIKPGGAAAQPWPPQRQAVQQQQRPQVPQQQEPQFVVFEFFGQQEQNNLNVQHQQQKLFNKWTPFSPLMSSSRPIVESVVPASSSGVRFATVQLGPDHPSMNSSDYMVSRQRSPHRSSSSRLLFDNPMFRRLPNWHFFGDDRRLVPIPPLIPLLPAMPIERTLLYIAPNESSSRQLLLLAMLDMKRRSEIMGMPAIADNSEVLQMTEDDHDLPTSSSSSLLFLEQSAVSVAAELLPDEDLLLPVVPACPSSTSGVESMSSAEESATTGRSSRSTTPTEGGRSTPDKHHHNAADEDDVDPEHEDDEEDVQTELLTEQHRPDALLASSATDSCASSTPNSPPTFDRRIVRMSRGTRDAVRRLSRRFEEEEEEGEEGEVHVSAVETMAENTFALPQSISPPPSPPVPLAPPTILMMSTAGHTPIHRSRHCSAGSNSAPANNKRSSMNSDEAISRMDVLSERIRDFHYNEDQTHAQLNRKLQLRDQLYYAISPIFPMCGLYIVGSSLNGFGTKRSDLDLCLMITNRDIDQRTDAVVILSSVMRTLESNKIVSEQNLILAKVPILRIKFIGTFHDITVDLNVNNSVAIRNTHLMCYYSSFDWRVRPLVMVVKEWAKRHGINDSACSSFTSYSLVLMVIHFLQCGAQPSVLPNLQQMYPKRFNGRADVRSLNVSLPFEPIPTAMGWQFKEDAALSDLLLGFLRYYAFQFDFDADAISIRMGKKVNRAQVAQNQSPFNTLSQWHCICIEEPFTLSNAAHSVYDERIFQDIKKAFVDSYRELDKQRDLDRFLGTPVEPSTELWASRQLGRGLHLSCRLTHRFVEIEGLICSNGCGIRCHKLLQHILKPYDLGHHCGTGRHRDEKGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG77</accession>
    <name>A0A914HG77_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HG77"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16873.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16873.t1"/>
        <property type="gene ID" value="Gr19_v10_g16873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16873.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14377" checksum="A81641BAB4941EC5" modified="2023-02-22" version="1">MEEISICADIWLEVFAFLVFVNATEPVNFIIHVLCAGMEPFELENNLTGERLSLRRFNELILLLVRCPIEREEAKWPKWEKEAIALNWYFRWNRIDNEFEWRKFEQKIDFNCCFSLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGH0</accession>
    <name>A0A914HGH0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGH0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17145.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17145.t1"/>
        <property type="gene ID" value="Gr19_v10_g17145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17145.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22036" checksum="E9B4912F8A8A8965" modified="2023-02-22" version="1">MRIANCPEAKSAAKSDARAVNARRHSLLFLNDWTSLSAPNPSLLRLFVSKMSAFPPACNPAHARAIGERERAPMQQPQTNDRGGSGGKHAQTPNFKLSPRFMLCRCRSQSNGGGVTVDPSPKALLLGPLPSSCPPFGVDVRCLLADALRGLFSSPVASAVAGGCQTRRGGGGGLSNFCFSEGIPRGGTSADGISHAKNARRCLPADGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH22</accession>
    <name>A0A914HH22_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HH22"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17103.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17103.t1"/>
        <property type="gene ID" value="Gr19_v10_g17103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="11">
        <location>
            <begin position="132"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17103.t1"/>
        </source>
    </evidence>
    <sequence length="579" mass="65941" checksum="6A277F923F095B83" modified="2023-02-22" version="1">MGILICNSSVLNLDVVLCNGQSFRWTKDADGIGWIGIFCHRLWHIWRSNEHEICFKVLHKFAGNCCNENNEKTDANLLEEYFQLDVDLERLYGFWSSQDIHFAKLLTENREMLQGIRILRQDPVETLFAFICSANNNIPRISQMVEKLCQFYGDSVDSNSHRFYDFPTVAKMATHLPDMEHTLRTAGFGYRATSIVKTVEMLASGVLTINNSAEDWLRSIGDLSYREAKLSLMRLPGVGPKVADCICLMALNKHQVVPVDRHVFNITAQIYMPKFMKDRKTFSRAIYEKIGEFYVGLHGDYAGWAHSVLFSTRLRRFALNMANKKIETVDFDEAFGLLEDARDQQQALDEEPFPTASAATVPTSGPSSVDHPLQQPIHPVAEQLEERVPDESDEPEEKRRKGTAEEDESEEAIPPLPPKLDEESELARLKLQLLLSNFTQEQLDRYEAMRRASLPKSIIRRLIHQFTGVTANQNVVIAIAGMAKVFAGELIEEALDIQKAEREASKHNGKRNPIDQAEQSAKSPPQSADGPLTPRHLYLALDRLDRQGRESRHRMIFGFPLGLYRHWTRARFEPGAMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIA9</accession>
    <name>A0A914HIA9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIA9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16882.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16882.t1"/>
        <property type="gene ID" value="Gr19_v10_g16882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02959">
        <property type="entry name" value="ERp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037462">
        <property type="entry name" value="ERp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF23">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="114"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16882.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36627" checksum="D142CB26C0F6A1AA" modified="2023-02-22" version="1">MTGLIGQRASGAAIGRTAGRQRQSCFLQPPPPLFDTNLVAVLVDANKDRDQARRNCLKTPKTYRPQQPQSALHTRLEMGTAVAGSAAGRSALVQRQPNTMLLSSRTTHGEDVAKKFQDIAESYKNPLSNGFGDDIDWVPWDEAIENALDKNKPIFLLIHKTWCHACKTLRKIMQQSNAKKAFKKLSEYFVMVNTADDDEPFEEEYRPDGKYVPRILFLDKNGDTLTDFKNKKAEYKNYAYYYSSPADILNTMKDVIAHYGIELAQELKGDKLKPKKPPPKTAPDAPVSSNKKSEKKGVEEKKEQPKDEAKPVKKDNKDAKKKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HII0</accession>
    <name>A0A914HII0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HII0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17481.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17481.t1"/>
        <property type="gene ID" value="Gr19_v10_g17481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF26">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17481.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30505" checksum="3DBEEC47BD0A999B" modified="2023-02-22" version="1">MVKLFVGNLADSIHADNLRGLFQRYVQVQECDVLKNFAFVHVSTNVDADVAIQKFNKYYLEGKAIHVERSTSHFRKQPGMGDKCFTCGAEEHKTSECPMNQCSSRRKRERDSFGEESAEAKKPKPSDFVPGKPKPLIFDNDVNSITQPFPAQVNCWGYKVEGGNGSDPELPRPLNPELRTLYEQYLESRTRYFFYREQLNKELRLQDVSAAVAPATSGPDTTNPNPGTGCTHNHTTTASKCLFQFLQFSIINVNGCGTTPSCYTGQIHCTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJB0</accession>
    <name>A0A914HJB0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g17153.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17153.t2"/>
        <property type="gene ID" value="Gr19_v10_g17153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATPase activator activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein-folding chaperone binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Signal-induced proliferation-associated 1-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF22">
        <property type="entry name" value="RAP-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21022">
        <property type="entry name" value="Rap-GAP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="7">
        <location>
            <begin position="1557"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1236"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1331"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1381"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2043"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2107"/>
            <end position="2182"/>
        </location>
    </feature>
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        <location>
            <begin position="2192"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1242"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1335"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2051"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2118"/>
            <end position="2130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17153.t2"/>
        </source>
    </evidence>
    <sequence length="2251" mass="250046" checksum="DD2EC97220B5DCC5" modified="2023-02-22" version="1">MSVEESPLLKEFKTFLQATLVAFGSDGALFSLVNQKFSEDWEGSPSLKEYADKLGFGPKGVMKLMESIPDQVTIVMKPNGEVILKPVPMKETLDNLAKIDATNRELNTERMRRLHHQRPPPDVVAAQMAGLMPNWPPSLASQPLATMFFPGRRTASVGQQPPPPSKKVNANLIPLGPRRLPTCSSTNNIVNTDVGAQGGPLMMSQPKPPLPRLMTFFGPRQHAAVRNDFGDAVVQPPQQQTTVVPSSSAQSVPMSPSQQQKNKNSPQKSAVNDAGQKQQQKQTRRVNFGQGIRYLEMEALKRAESDAYYEEDFRASASPRSASPEPKHHDVFKSKSMEQMVLKEQNVVENNNKKDETPPTVKMETKLSADEQHELVSDANRPVAQEMKIKVDEKIFDNVGDYDEVEDAEVEDAESDWDFLDEDLDHDDWLEEDDNKECDDFLNKFERKYSTPVSGDIYRLVHLFRQNGGSFSNMDTLNKAYLDTYRTSLVSKERNRLLGAPTATRIAKDSFSKAAYPGLFRVSERKSSCYGVTLLPSLTDTSVFWSTKVSPDNDALFVPSASPLAIMPSCPPSTSASIKESLTPSPVQAMDTTAQKSVKQPECVDVQLAPFSGMDTVLNDYAVLLDSLREPPLSPPYIVDQIVRQDGIQHVVVKHLDTQNDHYVKMETIYSFPNELLKSNSTLAGMSRPFKMADHPGIAVTCFVVPTEKQQIHCFNAADKEENAIKPLCAILCKMAKWGEGDPRWIVEERPDATNVNNWHWVEKNATPWSQERLKGLLLNQSLEKGSIRIVFSDFKKLEGEATANNRKAKLIFFFEWTIDVNFIATICGSEIEYKGNVEIHNLSDENEAQEIEISTHVDTPGPHDNEIRHILSIDGLAFVRSQMASYVRELKEEFSKGIILPVDSKGAIRPQANDVVRQSKAKTEPIEEQKSLKTVGFELVETFKVPPDRLFEILTESQFVTAWSPNSSIDAREGGEFSLLGGVILGHFTNLAKDAQIAMAWRLKSYPPGHYAAVKFVLKDKGDSTNLELSADGVPEHLLEDTKTGFSRYYFQCIGKNKSLRFITFDHTNNRECAILPPPAPALFFYTPSLLAAPLIFMSGRARLGRQKRRMGAEANEREWILARRRPRARQMRGGGRARHSPSIHPAFHNQLEFQPEGNLSSTKCFTTERATANEQKQLRNNAGHWSPFGLLDDGKMIPPAACPSAAVEQSTGTPSANAQSNACAELAIVVSTAAEQQRHLPPPPALPPPSSSSASVSSANLLQCSLSQSSIHESAIGALRANSAIPPSSSGNGQLAQSEWHPASAQLCAYHDCRSLAYAWGLGTSTSSLETTRPTGASQAQSPSEDDPGDGKCNDLLANCPAFRNELGDEPIRRIALSRHTFSGQSQHIQQQQRINGRKRSPPEEAAETWHREHMASEDVSNVYLGGRLCASRQPRVVVEPLDLGSYYYRHCFAGRNHVEYVGMDESSGPICVSMVREESKDGTSTLHAIYRLILRVSDVLTMRVSVPDEALSDAANQDRSTRTLMRELLEVVCPQVHFGCLRPALSVPKVEELLLKIDEQPIYTRYKVGVLYCKAGQSTEEQMYNNEHSSPHFEEFLDFLGTRVRLRGFESYKGGLDTRGDTTGLYSIYTEHHSAQIMFHVSTMLPFTPNNKQQLYRKRHIGNDMVTIIFQEPDALPFSPITVRSHFQHVFIVVRACNPLTEGVTYRVAVSRAKDVPAFGSPVPASATFQKSAEFHDFLITKIINAENAVHRSRKFASMAARTRREALKDLLENYAGAAHSNEGASRIASRLLGGSVKRKERVVPKPVLDAAVRAAISWQVDVFDHSSGQRTPAVLGLSVDTLVLLSVPSGLAVFSTPTHSILGWIQAADGGVKIFFDHGDLLLLWCASPDGSERELVLLLKRLAAVTNGEEAKEVILHKNKAQAESFGFHVQEEGIVTDVDMNKSAWRVGLRQGSRIVELENAAFFTFSQEHIAILLVERSQIKVTMIAPASDGNPRRGCEDPNCPAVRGLECQQLLTPDSFARQPLAYQQMFALRDQQRRGDVKLSSNSSSESWGNSTPPPMSLMAVTERKKFSAPTFGSVANRAHPLETNSSVDSIQSRLNHRPQHTSFTGPSHPQKSQVSSSSAFGRARSDDVTTKPPVPPVSPKSSLQTTPVCGGNSEGVDRAQQNQRRRVSTDGELSRYQWCLQKTVAEKRELEAELEQYRAQLQAEQRAHESTRRQLQMIMEYCERFSIIPPPFEEEDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMG2</accession>
    <name>A0A914HMG2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMG2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1930.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1930.t1"/>
        <property type="gene ID" value="Gr19_v10_g1930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1930.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19705" checksum="C73A0079B2A421EE" modified="2023-02-22" version="1">MFISQTTAKNECQKDPIKTGQELLDSAPTLFNGIKSESFGDRLNVAHSRDEADHRSNGGNALRQHQRENALRQHQRRRRKRMRSFEVMMSDAIRRTSTPAAEFQPTRYGTKGCIVLFVITVCTVGAAIFIGLRLSGTDNNHTSIIAILAILIFAFLFEFVMLMWYCVMEHDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMH1</accession>
    <name>A0A914HMH1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMH1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2150.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2150.t2"/>
        <property type="gene ID" value="Gr19_v10_g2150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037505496" evidence="4">
        <location>
            <begin position="21"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2150.t2"/>
        </source>
    </evidence>
    <sequence length="771" mass="89001" checksum="82A0F4F423B83682" modified="2023-02-22" version="1">MLILPIVFVGLINLLKKSFAIDLIRPFTNVIEGNSELIFYHLAKIVPAGNYRVIIWDQQTGHHDLLINSASSNLCNGREIFVARRGISIDRQFVFLVDVLKNHLNDLAKCFVHFHTVKTDETGRFLLRIKSRVANYSLFNKQFNFNLIPLNENFDPISDDATPGAAAQRIYVQDMLDPADSLCQHTDKQCLINYYESDIDREAHITKLLSNRWLQNRRYNDLTEMENFFIIANFRALIKSAKKQSAANGIQMATTEYSLLGHFWNSLARTRKNGMLWKRLRLVNQQMLVLIDEFCEISEDFLTSLSQLMVFVAKSNEPKNFCPNWPVVREKASKFTNSGIVMEAFGQWINTSEQLSNEKEQIIYFWIENKTMICFTKLVLCWSKQKMNNISQWTKLLFEAIVDCRHLMPWHDQLCARGEFQTVSVRPQSSVSVAKRKCSNVLDLNTVPDEDQPETSTTKTCVICLDKERDIAFSPCGHLGVCQRCSERTKSCPSLEASKHVIVTGSGFKIDDFATIQIWQRSGWRKHKHKKNFQSTPLSRMFQPVGTRATLWVNASPSNEELWSSELCSLLRPVEEASRKLCERDSSIAVQIAIANILLGELTEKTYPIIEEEQRKLISEIRERFSNLESKRIYAVAHYLDPRFKDQFVPNRLEFVSKIHSWIKSDILLPTNSGEILIDKGLHHQKRSSSQPAEDIEFELNLYRKADLEPLDILSPIVRRYLSAQATSVESERIFSVARDVFNYRRNLLNPATAEMLIFLNKTLPIINYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMR3</accession>
    <name>A0A914HMR3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMR3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2217.t3">
        <property type="protein sequence ID" value="Gr19_v10_g2217.t3"/>
        <property type="gene ID" value="Gr19_v10_g2217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2217.t3"/>
        </source>
    </evidence>
    <sequence length="640" mass="69147" checksum="F25BE1FAECB24480" modified="2023-02-22" version="1">MHNHHQQQNRSTSVTPRRRSRMASPPAFSAARLFAKLSGHQQQSIEQKMAELRAVYSTQPTPPPSTIAATQCSNGSCNTSAKGSFSTLTAAPRRPGRTSLPTPSLGDMLEPLQFGSRSCASSRRASTATTCFPAPSIMELASSAGLMSLSPSDLVFESSVLGIAYYDFVLSVCEVSPCDDTVSIAAGAVARKNKAACVATSTLEPPASACPRGSLTPAAKRRVHGTGSDPTQPSPAAVVVAQQQRKTGAVGGVLAKLAESGKKRPQTAVSSSSTGGAPGDRISLADNIAQLAEECETKIGLDSTDQNITAYRLLLAKLDRKTNVEWFESVIVPAELLERNGIPVSELSLLTMGILVWRCTLNNARLLCLVNGVQQQLHEDSSTITASFEALKRAACKYKCMHHVITVGQRRPSAASTHSSCSSRRSSLSSGSYGQNYQQDSGMKLRVLMCQSRSELQELPAHALRDAKFLLASNTNPLNEEIIDRNKQQSNVECSFCEKKCGVIYQCYKVQLKAFTDLETLSFSIRGDCGGPLMVERGGLFYAAGLAVSSYNPPALRNILPDSYIAVNEHCDFIAQSTLGEAKCLANEYTENEVEAKCSNKFQRILYENYQATCSFLDSDDDEENEKVCLENVRPPHLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMU6</accession>
    <name>A0A914HMU6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMU6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2760.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2760.t1"/>
        <property type="gene ID" value="Gr19_v10_g2760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2760.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7911" checksum="7267CEDB617AB82F" modified="2023-02-22" version="1">MNHLPKKRDQCPPAKKVSWYPPRPFRPINFLFTVSPKGILPADRRIFSQGLLHIATEATTPNPIESLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNC4</accession>
    <name>A0A914HNC4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNC4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2367.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2367.t1"/>
        <property type="gene ID" value="Gr19_v10_g2367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2367.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18840" checksum="FCFE778E70BBB726" modified="2023-02-22" version="1">MSFPKLSTTTTEISSLPTTVTSSPPAKFAETKWLGKNKRPACDEKEEKKKKPTKPTEQKEVPPTTKKTKMEDSAVKPQESEPPVEKKRKVEDREIWKLMKGKYLLSFYLCPDDWKKLYNRENKVVRQENGHFAARFELCADCAWANVRATDYLAPPKKKTMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNN2</accession>
    <name>A0A914HNN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">[Histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g247.t1">
        <property type="protein sequence ID" value="Gr19_v10_g247.t1"/>
        <property type="gene ID" value="Gr19_v10_g247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF129">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjN" evidence="2">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="154"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g247.t1"/>
        </source>
    </evidence>
    <sequence length="1091" mass="123464" checksum="D28297F75A25FBFE" modified="2023-02-22" version="1">MADYRPIYSKEREWINSGTPDGEIMTFHPTMEEFSNFSNYIETIERSKAHLASGVCKIIPPPGWHPRPSKNPSDYSDLNDFIIHYPVKERIEGGSSTGCYVKNNTVYRKEMRVGDYRRMALSKQFRPPKPNYDLNELERHFWRNLLHHEPIYGADSPGSIYDKDVAHFNMNGLGTILDLLKEQELEIKGVNTVFLYFGMWKTMFPWHVEDMDLYSINYLHFGEPKFWYAIPPTAAAKFERLAAQRFPDGLQICKAFLRHKVYIVSPSVLRTHGIPFGTMVQYPGEFIITFPRGYHMGFNLGYNCAESTNFALQRWIDYGKNAVLCYCRNDCVEIDMRPFMEKYRPNEYKEWLDYWYGEQPASYNRAKSGSKSSSVETSNSDASLPVPCTKRQKAIFKARKLMDALWANRPVDLYAEKVHNSRSGRLYPHCVVCQYFVQRSVWMKGTPVEKLPEKSKKFVSEQMFEKKIRMEGLDLGWTMLKDDKLMECSNCKVVVHASCYPSHERVAKFPQEQNDHTIPSTSAHPSSSSPALSTAEWLCERCNNRNDVLIRSTSCALCELRGGALKRNCHFDDAADSNVSFVHVICALMDPKARFVQQTSDEKMQCTEPTSSSRWMMIVLQSHQLAQRLQPIDGMNNAHDDLYCSTTSLQCSSPSPLSNVSTPPHLFPQTDDAPQHSTKLSENLMLQSHEQNASILTDSGLADTLSTSSDATVGCGGNNAIAAHPIPTDVYDHGPDHDYHERPLLDANFLHQQPSLAVDLPALSSSSALSSYAVGSSMSPHPGSSSNSCSGHYHAPTATEHFVNSRNGDGTRNERHPTSYQCEVCGHQSEHLVRCAICVDTKETGAKLRFHVTCAPLADVTFERREFPGALTVCAFHHSAQFSSVDSDSSDSRVFELKQRVIVDLNEEEEEEEDDDTKKDDRLIGYGLIYSISEHLYATVDFMDGTSSSEVFPCDIVDCECKMFGCKGSAHIPGALVYVRWDEDGKTYQAYYRGQNPRKKYRVKLYPPLSFELKKRKRAEEAAAAAAAADEGGEAASAVAKNNSKWRDDEVEVSSEMIYRRDDLHPEYIRLALLKRKSGESNGQKLYVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPL7</accession>
    <name>A0A914HPL7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPL7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2719.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2719.t1"/>
        <property type="gene ID" value="Gr19_v10_g2719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2719.t1"/>
        </source>
    </evidence>
    <sequence length="362" mass="39619" checksum="52F148585210235E" modified="2023-02-22" version="1">MDSISNVAWLLNPTSGGERDRNMADALGTDNNAHAPPRQGRPLSQHSTMDYDEKEDDMAVIDKTPYDEGEQMATHGRLLLFVDDSDGEENDDIEEKEDVEDIELGSGDQNAEKLVDGEENGGNSASADAKATSAPATGDTATVEEIMEPTEEIIFPLLDYLCTFNDCSLKELQVLFHSVQARQRMVTHLQHNCLLRTGHLKPPERNVGLHCHDLSAQNANRTFACGGYLELTVRQYYFAKHGLKLKHPYLPCMIEFGGGAHASYYPLELVHVIVEHPKQQGPHAVAFLKLLNRNNNNNNNNVSSSNAGVADERVTDARLSGGRPAAEGLPSSTPLPAPQAPSHRCCCCCGCGCTTVETRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPP6</accession>
    <name>A0A914HPP6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HPP6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2562.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2562.t1"/>
        <property type="gene ID" value="Gr19_v10_g2562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002484">
        <property type="entry name" value="Protein CBR-LSY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2562.t1"/>
        </source>
    </evidence>
    <sequence length="604" mass="65277" checksum="8ABE0523C0D83E5F" modified="2023-02-22" version="1">MLQPPHLQQLSLVPQPSSDAAQQHQQQHKAFVCEICGKAFRFRSNLAEHRSVHTAVKPFVCKFCGKSSRLKGNLTKHILKHHKIEQKEYIGTDDYIIKKGKKSVKDPAAIEFLEKSMIILNNGGNNPQNNAAHQQHLLNAPGSHQSADSGSTEHQNGDFDGHGILLSLGLDSGSLDLKAEEAMDEGDEDDNFGDHHHHEEFTDPENNHQETKPYILNSTANERLLEHCESAICSGDSDSIERHEMDDINEADADGAGADDCSGAECQSSGTQSPILAHESTAGTNALAAAACKALLFGQMDNKILAKALLSSSRTANAYGTSGQKDTTSGALTNQQQAQATNDEIMRILQQVSSMTEQQQHQAVHDSDQQAQNVSMVGGSTSSSSKLATQCQLCGKHFRKPRDLMAHLASSAHKFPASTPPTTASWPTGSSSSSSNLKDYYSVNNSVNPLLLLPSSNGTPQTTLAVDASPINIPQQHQQDVIGQFLKDMSPTALATPLTAATRNKSGDGGHQQSQNLVVNELRELRNTVAELRTSTGSSNKLEQMLGQLDSRVCRLEKQLDMALNSIYTLVQLQTGINNSVQKLASATPNSNSANHRPPLKTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQZ7</accession>
    <name>A0A914HQZ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQZ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3098.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3098.t1"/>
        <property type="gene ID" value="Gr19_v10_g3098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3098.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19170" checksum="31B755F65F6657DB" modified="2023-02-22" version="1">MPKRPENFRILNKIETEITNFSQHSNCLLQSYNVQLLFLLMLLQPSYSTEVEQRRSIATFHDDLTVHIGDRQVTVSASWLMVVSPVIKRMLSVEMKEKQQRALNLDGHDITMEQFMQFLDTVNDHLQHGQTRPNPDDVADIKRRLSFNARTSIDGVATSFDLVTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR91</accession>
    <name>A0A914HR91_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR91"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2974.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2974.t1"/>
        <property type="gene ID" value="Gr19_v10_g2974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2974.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19612" checksum="0751012AC45E53EB" modified="2023-02-22" version="1">MAGIRPEDALLVNGKLVNVNKYMLAGYSPFFRTLFFGENADEIPKVQIDEVPDAVANFERLIATMDPLNMDLDDECIENVLMLANRFLLGSVEKCCVAFLLKKSKRSAIRKFRLAHQCGIIGMKMKILKEMTKEDFAVSRENYFSNLSEINKLGDAEIEELQKRHKKLFGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRZ3</accession>
    <name>A0A914HRZ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3407.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3407.t1"/>
        <property type="gene ID" value="Gr19_v10_g3407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3407.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17504" checksum="69F67511B2255875" modified="2023-02-22" version="1">MPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQNTPLTESDHSENAKNGIDETVAKELGLSLATIYNWKRKLGQTEPNHIYSDSEQKELMKRYYQIKDKNRKISDVDIAKMLKIGSATLFRWKKQFKRQQFHQNSVAGHLVEEKDGSNVPEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSR4</accession>
    <name>A0A914HSR4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytidyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSR4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4301.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4301.t1"/>
        <property type="gene ID" value="Gr19_v10_g4301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000089">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="3">
        <location>
            <begin position="128"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4301.t1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55378" checksum="8817F2E03CB34470" modified="2023-02-22" version="1">MGGSAAIDVGLLVLRGNEALIRQKLTRLLKITIPKVRQRLYVHLEEMEGIRALLPTIYLNASTIEPQIDLRVLLDIKRNIPVDRVFYDEVKDPDRPSFPMLREENGPVYSMNNLTAANHAGKRYEHVVLGGTFDRLHNGHKVLLSEAAMLARKQITCGVTDGKMNESKILCELLEPVGKRCRSVVEFIEDISDGISCNAQPIYDPFGPAIEGNHFQAIVVSEETLKGGKAVNAKRVENGFNNLDICLVDVLKNECPDAVLKENKISSSLKRRELLGTVLAEPRKPKEAISNEHYVIGLTGGIASGKTHIAKYLADKGCEVIECDSLVHQLYENNEELRLKLKQEFGDEIVENNNINRNRLADIVFGNKEKLAQLNALVWPVVVESVRATIKQTKKKIAVIDAALLLEAGWGDYVDQVWTVFVPRKVAIERVCVRDKVSEDKACGRIDNQFPNDQRIAKSNVVFCSQWDYSETERQVQKALETVKQRYLGEKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTC4</accession>
    <name>A0A914HTC4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTC4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3574.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3574.t1"/>
        <property type="gene ID" value="Gr19_v10_g3574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3574.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11100" checksum="1A29B2FC232A69A5" modified="2023-02-22" version="1">MHFLNSKNKCSNNCISTNLRNAVLFVLLHIFLEKRGIPTIPGQHKRPEYFLYTSGCLNLTRPDLAMLRAQIPVQNGATNDAKSLGNETQLCEAFNYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUJ0</accession>
    <name>A0A914HUJ0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase A(2)</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUJ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g48.t1">
        <property type="protein sequence ID" value="Gr19_v10_g48.t1"/>
        <property type="gene ID" value="Gr19_v10_g48"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053322">
        <property type="entry name" value="PLA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228">
        <property type="entry name" value="PROTEIN CBG09474-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037985335" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g48.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16855" checksum="17FB390D39224EB4" modified="2023-02-22" version="1">MHFLFICSLFFANLAFCFGQNSTLDTIVEEEIKLDAEWACGTDIFSKLLAESTVEKDCPEKKNAINNCCVTHDKCYDALAGRESCDDKFCACVDSAAAGNDVCSKEDMPHFCNLVREFGGLFYNTSANSEGQKLVVPTIVNGKKNKRGIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVP5</accession>
    <name>A0A914HVP5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lysosome-associated membrane glycoprotein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVP5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4921.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4921.t1"/>
        <property type="gene ID" value="Gr19_v10_g4921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048524">
        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21222">
        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00336">
        <property type="entry name" value="LYSASSOCTDMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037227735" evidence="9">
        <location>
            <begin position="32"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="10">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4921.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29216" checksum="7602ACBFA53CCF17" modified="2023-02-22" version="1">MTSKRLECPSLNFSIFLLTILFFLNSSGANALKLAVKGDDNKYCIVLDSPTITGSIRYREQTGGSFNTTAFTVSNSSAAVVYNGTMESKCGKNLQQMTIEFVPLIAGLDPKQLDKKWKLTLLFNKTDTKRYALADYFLAVTFFAAQNASEVKHLYKKNGTAEWGAQLESEQSKYSNGYTCSENKLTLSDASSLSFDYLKLVAFYDNDKADFRDGQIYENCPLDVRTSDLVPIIVGALLAGLVIIVLIAYLIGRARAKRQGYTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXL4</accession>
    <name>A0A914HXL4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HXL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4716.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4716.t1"/>
        <property type="gene ID" value="Gr19_v10_g4716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24392:SF31">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24392">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4716.t1"/>
        </source>
    </evidence>
    <sequence length="597" mass="68398" checksum="AC98BD522A7384A2" modified="2023-02-22" version="1">MSPQYGILHIPSNNHNGKMSRFCNSYIEASNKRVQAEFGVIGEEFTGQFQCTFESCNKRLKNNVIFMYHIWAHVSQHKPTKNEEHSSNLQNLLAEHSGAEDEAKADDQRIDVSRMHTCPECLLEQPTPYKAKLHYHRVHKRGKRPLLDSNPELLHVCNICEQVIDTKNMQHYIVAHALPNKRLLDLPYECRFDGGKCQFRTSNRGALLQHFCNKHVGTHFVLCPFCLMTFCVPPTDKRDSLVRMRDFVLHMTMHDAEKSRHCGHCVIKVAISQRAQMQKHLKQHTKNGEHKWLQWHMEQLDLNSVGPGPSYALISSDMNTQQCVECGQMVNNHCRHLSIKTKRCKFCSFVTRCARAMDHHRMLSQCNPSNAVRRPFGAVAGWTFSLDNISCSTFSPSSSSSSLSSPVLQQFACAQCAFYSVNVQTLAEHIAAVHATCSGAQVLLPNKNNGRQQKLEEQMMLNKMGEDGQGGDKMEQDNKEVGEDELREAELFGLLRMADTPLENDDDHDDDEGNNKDKQQQISAWLSEFLPVARANELSQREIQPQDVRLLKQLMEMNRSEDEERVQRIEEEEHELRVKMGLMHDDFPKLDCKTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYC1</accession>
    <name>A0A914HYC1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HYC1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5160.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5160.t1"/>
        <property type="gene ID" value="Gr19_v10_g5160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053302">
        <property type="entry name" value="CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159:SF6">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159">
        <property type="entry name" value="PROTEIN CBG07705-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="760"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5160.t1"/>
        </source>
    </evidence>
    <sequence length="1127" mass="128820" checksum="4FED78DCA3914B79" modified="2023-02-22" version="1">MDHWINSHRPGPSVPTPTALFLTMKNDDGKGGEEGKEEEGLEIEVEIFRREGEAKSGKKKEHLAIEAKESKVKAQSNVDEEEKQAEELKKASEEKEEELKKASEEEEEELKKASEEEEEELKKASEEEEEELKKASEEEEEELKKASEEEEEELKKASEEEEEELKKASEEEEEELKKASEEEEEELKKASEEEEEELKKASEERVGPAKGVRFMEKSEKEGADEMERLEEYERKLRRNTKEALELVDRLCELQQGQPTTPERTTIQRLPVTNDRAETVDSGELRRALVRGVNQIGEKAAGDGGMAKTDIGEGNDFDVESVSLSSRLLLSPTDCLLLPGHVLLLVDTQLGLSLVSLQSRQLIKNICPPENGHWRNAQCACLGGDKGQEQRVIYVLLEHRRPKDGASEGSGICRERARSRLIPEEEFDRKPRSAPVNNADTEVARDIQAQQNGREAQTEFAHFTECLYLAANTPNQGFLYELNIHQGKWTECAGTKRFKNYSDLHPFAVVGPVTELLLVETNRCYVQLMSVYGSKVVNDRMLGLCERPGSLCVDERGNLFVFDRANSKVGLYSRTYLEKMGDIALVERANCRLSAREGVLAVMCGNCGRCRRGTAQPELLLPNIWFIHRPLIIRTFFKRRVSFLLFNPPNSAASVMSKRPSTELGEPLSDGSLELVSEVRHLCLFPRHPNFDSDFNIYRFIACAERTHRNRREIVESAAKALDQHIRVRKCMKLDEVPSFPMEQNRLFRDLLMPFGRITEGVTDSRNRLLWFIEYRSMSVEKIAHGIRSSESIRFQFWQFEQMLRMVNRQERKSGRLSSIRHVIDMAGYEINPFTTLFVSSGTLSYYSQLFHYDNYPELIYPIELVNIAKWIQLPYRMIRGMMPSGFTDRFRLYDGNFLQKLTAEIPAEFIPQTLGGQNEAIRCVPASPLLHHWQPKHRRILDKLQCFHIGARKSKAFRVQIEGAGGTNILSWYLRTDGDIFLGVFFEPNENSQCQQNGNSADSKGLSISSLSADQKGQQSKVSVGGEHQMADQLEWVYPWFKLSARLHHEWDCVDCSRPGSYWLLFSNKHNWLNRRTIEVIVQIERVAESGKNKIRNVFPEGKEPTIEPEQMFAGACPPTHATEEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0S3</accession>
    <name>A0A914I0S3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5550.t4">
        <property type="protein sequence ID" value="Gr19_v10_g5550.t4"/>
        <property type="gene ID" value="Gr19_v10_g5550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase central" evidence="11">
        <location>
            <begin position="1533"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5550.t4"/>
        </source>
    </evidence>
    <sequence length="1836" mass="214966" checksum="3DDC1584C28F8522" modified="2023-02-22" version="1">MEQHTYTEQPQRQNFQYYPNPPPPVVYERRYAERDSGPRCVPCCCCFPCIPIPLCFDCNFPPTNILYGIDRRNLDNEYCRLLFDAPLDHCAQMDIGTRLGALLVYESIETDLAIIDFRLGQIFERNKFLAAYNLNKSTIRTKFDELNTKIWNKKVGEKRFGMDNVCRLWSFGLEVTKLNDFLNRNQTLAEKEMNKLATLLKLNENSECKQLEKIENVFETKYGELPLWVGESEFSHTLRMLNGRGEIDQIVRMKQKMNRYLMEYKYIGMLELHNPLTMAFDIICDSILKTAFRGIIMFDGIMSDEMALQNKKWIEISLLCGKIIDYFMQQIQNAKAEGANNEAKIAKIGNHWKLFARLLGLFKNNSEFNDQKLLLNKLDTLFDYLRGQFGEHKLSFKYKRMVERLELCFLELYEQNSEFRECLRNNLSSMAVLKELFEIAEANEQIISEQLWAVLVKNLSGEKEIIVPLKEKVDDQMPIPTLLECPDKNIPLEKLEQVDDEEAKKDDEAFSLMFLYKEAIINAGDNIDFHLHLIELHELILLPEEDEFRWSESDCADEIVQNKLISAFLKDRMAPTQFHLAAWDAVFRRFGQIRHFFCYGTDQIEVAIVKENFRYTFGELLLDRLELVHPKIMRFESPAYSHFLLLLLQQLSDKTDSVPAELAEARKYAPLLLLDLQFYEQNLEGDLAERKAMGEAIQSAKQNFYRYLIKMQRSKKHSIRNAFCVLFCSHGLLKRKMALNLKWNLIYAECEEEANVKETIAVQRHRMRGLTLNFLSQTIANKLFALPERIKAIRGGRTRLLKMLYDPDISFEQNEEKIANLWEAMHLDLSTIDYGDSELLISHYEEALLTDDDMIRIEGKMKAEICVFFNWINSQIFSKNSFLSAIRNNGRKYCDLSLQIIDDFYDQIFDERSAEVEQNEHILVDLIFEIKTQLEKILAGHSMKSSELELLKEWQKWHLNRLMDRKAGKSFVKAKHWNEYGPWMRQLHGIMFVQLLKMDKNFAQKLKNEFETSLMKKNYLIELLDIEKFVAVHIRTEEAAHSAERRHSKMPAFPALQQFGEENCENCNNWGVVAAHSLLKLLDIGILANEIWHSVEAIKALNESKCDERWANIEMELAHLTEKEFVVENAQNSNSEIEFCQQIRHQLHLRKFSMALFHSGRFWSNLSEIRRKQIVSTLFRVEDEKTIELFVGKVEKYLILIKKLNEQRNLDESLFNEYKNGLNKFVSKKAKKKLHSDKSTLPHEFAKNWQEINFVENSNRKSKQIIQIKNYLMANGYFSEAERHKNERIVSELTRIVEEWCPDAIVQFPMSLLGNEKLEPICILPEEIDRELIFGKLNFNFEMSEMGAKCEDKSLYCSLLMRSEFKSVQKIVKELTTLPTLKFNFMDVPIEMAFILVPKVKLANSGEPIGLRTYEKFAKYFAENIEHLLNADRYDEGIHMDEVKLQNIIRKQLEKSKSFNDKFELDKVLGELKQLTSTKEAALKQRQIVAEQKVMLLALSRNFISEKIVFEILSPDTKLEENSRGINKNERLRVALAYLELWAKNNFIHGRNMGYLDTPMLLIMMAKVFLMFPEASIPFLIEKYFLFYSKWKWPMPVQLAQIDDKRIGEFLSWGPGREWFTKRQFLAKNLRKTIGQALAMPIISPLFPEQNEAAQINLSTAKVIQNELKNAFIKIRSTDKGHGIIKPIAGNCKRFSEKYEHFVTFTCGGTKFNVEKFCHFVGKRLRHELLYFVENSLANWVRFCHVHPTRVPVEQSSDEQQQQIGGSNNNLHKNLWLVGLKLHKQKVQNKFVDELIDKLAEISAKIKKDFEGDLFYNVQLHSEYVEKSKLAKWISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I117</accession>
    <name>A0A914I117_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914I117"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6502.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6502.t1"/>
        <property type="gene ID" value="Gr19_v10_g6502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038159646" description="Metalloendopeptidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="540"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="652"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6502.t1"/>
        </source>
    </evidence>
    <sequence length="1088" mass="123171" checksum="69140B200BF4C0FB" modified="2023-02-22" version="1">MKLLIINVLFLLIALNAFAVPGGHYSENATWGECKLEKNGLFKLEKGCKTLQICYKSKLAGKLATGTLKFGGRFRLGKRVNERPLSDCAGVVARNEWHALNVSKTSDRIFTIQSSLGLDGQFNSVFHIKPNDFIEAMNISKDFGPIETDFLKALYLGAFMKDFGGMAFRILALDLISSIGQNDTGLCKKTCAFEPTAWHKNHFGTNCIEIVFPAEVPKFVLVVSILPYFLVCVEHESLFTSGLLPVDEYKDYVNACMQVPTEKCQFLVEVYACYQSSKKWPGSSSIAELCRKHLGVDLTSNVAGFRIRICVHREGQMLVVQSFFNLSFSNQTIETKWNFPITLDAITTSMQTLPIFFIEFGNGPQQSAIRDKTGGDPINGSNWNNEINGSWAKKLHFVPPSTDNMEIFFQIANLEFSKLINQDEISKPYENNPNKTWDTYSPCDDYGDDCGEIRELLKAIEDLESCHGNRPTLSEDAFKLPPWKKPPPASPFNLFKKRSETLMCHGGDVPCNKESLHEEYIKARKRCGLAPEEGNRRKKRQYLPEKTHTKWTEFPIKIGYFEKYLPKPYTEWKTAITEATNLIKKETCVRFVFVEKIPKDKKGVHGIGISNRTRACGASDVGRAPDWQELKLAMRNTECSTQANMSVVAAHELLHALGLLHEQERSDARNFTIPRTKDPQSEASETENFAFAYDFGSVMHYPGGYYNSQYHLITLPRFYQETIGQRERLSFKDTALINRIYCNDTCKEKNWCLNDGYLNPNDCSKCLCPDGFTGTDCRLLEFNLNCEDTSGTPQELEAERTNKVLKPTIKCNGSGPACRCYWRIKANGKKTRIQLTYLNEMFECVDPCKNYVLINYRKDKRAQGARLCCPSALRDAVPNAYKNWIEAEEPNVDFIISTHISTDLTEPTTLFELNYEAGAVNLTNSDACVSPENIYIQERNPGKNLTCWDEFGRVDPKCLCNGKAECLSQYNVSWSCPVFVINGGPIRKIMALKDYLARARARVATLYCFRPEGASKSFWGYRENATADPIRVDEVQCLSYRAAGVQPKFKSLDVEHRQFNQSAQPINVFMWGRTKNGGQISDDKLSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I196</accession>
    <name>A0A914I196_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I196"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g568.t1">
        <property type="protein sequence ID" value="Gr19_v10_g568.t1"/>
        <property type="gene ID" value="Gr19_v10_g568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03685">
        <property type="entry name" value="ClC_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="599"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="718"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g568.t1"/>
        </source>
    </evidence>
    <sequence length="788" mass="88207" checksum="94FB2A2D3FF06187" modified="2023-02-22" version="1">MYDGGFHTTVSTQTKIRRRREERLREQEEVRRRQFEDSRKLSDGASEHTLSEKYESLDYEIVENELYRAAEKDKGHQRKLFQKTVDRWIVCFLIGVATASVAAFIDVLVYYNSKLKFHLIINNLIHVCEEGNVGNSGCTWIILWVWALYNCAMVAVASLLVIVVSPVAIGSGIPQIKCFLNGIQIPGVVRLKTLVAKSIGVACSVSGGLAAGKEGPMIHSGAVVAAGISQGRCLTLPVDFGLFKYLRNDREKRDFVSAGAAAGVSAAFASPIGGVLFSLEEGASFWNQSLTWRMVFTAMISTFTLNCFMSLFYKQPGILSWNGLANFGTFEEATNVYGIWELPFFMIVGVIGGLLGALFNYLNLKLSRFRKKYLRLKRQKFLEALLVAASSAFIGFITLFYLRDCQPIGINPNLNEVTKLWCPKGTYSAVANLFFQNPEESVKSLFHSPSNSFRSFTLLVFAVEYFVLTLWTYGLSVPSGVFIPSLLTGAAWGRLFGICVQNLFPQLGEIDPGKYALVGAAAQLGGIVRMTISLTAIIVEATKNITFGLPIMLVLMIAKWVGDLFTGGLYDEHIDLSEVPILGWHPPKLSRNILAKKVMRKDVVALERVENVGRIVEILRSTRHHGFPIVNRIDASVGDSQFPNYGNLLGIVLRSQLIVILQKKHFTLDYEGKYPASGYKPISLEDFSEFYPRVEDKVSKLGLTVADERSWVDLKSFMHPSPYRVPLDASLDSIHRVFRGLGLRFLLVVDRENRLRGIITRKDIARFKERRVKSAYLVHEIYISPYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1B9</accession>
    <name>A0A914I1B9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1B9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g638.t2">
        <property type="protein sequence ID" value="Gr19_v10_g638.t2"/>
        <property type="gene ID" value="Gr19_v10_g638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000203">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0736">Signalosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g638.t2"/>
        </source>
    </evidence>
    <sequence length="325" mass="36815" checksum="8F5CFE3BD29F33FD" modified="2023-02-22" version="1">MHQNLLFAVLKTIEANPEKWTTDGCSNSKIQSPVYNSSAIARSWMESRDRLALAGADDARQSRENSNSTQIHYQIVCPSPQKMAKQMERAVVKFKPVNAHQEQQPPFVAIVIDPIRTISAGKVAIGASRIYPKGYKPPDESPSEYQTIPLNKIEDFGVHYSVLCGLPTAKFHRLHVYENCTNSTRQPAQKDGQADAARGRQVQAGQRAPGTTEMKQLNTEVLKQQQNQMLPMKQLNTEDLKQQQNQMLPMKQLNTEDLKQQQNQMLPVPFSSRCLPTAEMKQLNTEDLKQQQNQMLPVPFSSRCLPTAEMKQLNTEDLKQQQNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I249</accession>
    <name>A0A914I249_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="34">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="34">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="36 37">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 33 34">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 33 34">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="34"/>
    <dbReference type="AlphaFoldDB" id="A0A914I249"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g680.t1">
        <property type="protein sequence ID" value="Gr19_v10_g680.t1"/>
        <property type="gene ID" value="Gr19_v10_g680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 33" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 33 34" id="KW-0274">FAD</keyword>
    <keyword evidence="7 33 34" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 33 35" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 33 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 33" id="KW-0521">NADP</keyword>
    <keyword evidence="14 33 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 35" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 35" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g680.t1"/>
        </source>
    </evidence>
    <sequence length="568" mass="64536" checksum="18B2EB432E0A9F8C" modified="2023-02-22" version="1">MKVCIIGAGVSGLTAIKACLEEGINDVVCYEKTSQIGGLWNYRPNNVDCATVMASTVINTSKEMMAYSDFPPPCEFPNFMHHSYVQKYLQMYAHKFNLLQYIEFNTVVTKMTLNDKIWHVELSNGKSGKFDAAMLCTGHHCEPLIPEIPGLINFKGQVLHANQYRDYKGFEGKRVFILGIGNSALDIGVELAKIAKNVIISTRRGTWVFNRVIQNGLPYDVVYQSRFYQWMMSILPWTIANDFHEHRMQQRMDHDMYGLRPAHRFFQQHPAVNDSLANLLASGQITIANDISSIGEHSICVKDGREFGTDVLILCTGYTFGFPFIDPPELIPTKSQNDVDLYKYVFPPSNCVAKRLAVIGLVQPIGSVAPIAEMQARWAAAIFSARLELPDEAEMRVNIARTRATMRRQYFESSKHTLQVPFIPYMDELAELVGCMPKIKKILMDEPKLGLRIFFGPNVPYIYRISGPNKWNNAKLAINMLPERVKMPLKHGAIDKMPKRKCKGLVDSWFNYGITKCFALYFGVLFTVGLWLCARSDGCSSTMFITYNILISLISFTVWLFHFNVVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I252</accession>
    <name>A0A914I252_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vesicle transport protein GOT1B</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I252"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5911.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5911.t1"/>
        <property type="gene ID" value="Gr19_v10_g5911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5911.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15481" checksum="D4A929F0C0105289" modified="2023-02-22" version="1">MNFELSNTKQIGVGLALFGVTFIGLGIILFLDKALLAIGNLLFIVGLTLVIGIQRTLIFFFQWHKMRGSTLFFGGIFLVLLGWALVGILVEIWGFILLFGGFLPSAVHFLRQMPVVGTVLSLPGIRQCLDRFATVHKYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I256</accession>
    <name>A0A914I256_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I256"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5915.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5915.t1"/>
        <property type="gene ID" value="Gr19_v10_g5915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="634"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="828"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5915.t1"/>
        </source>
    </evidence>
    <sequence length="1280" mass="141610" checksum="D071F46A2C30F63B" modified="2023-02-22" version="1">MSGGTTQKGDDLKQVEDISQSQDDGELPHLPETLGSPSGGNRKVPKNCWKKRRLLPFRDGRRGGDEPFGRADLPRGHRRGGGRVGVSDNVNRKNGAETERPPSHKGPKEGKAPKGTREDEGTDRTTPDEDSRETGNNDQQQHRDYWYFDDSSNGYYYQHSGSQGWKKNRISSSSSKTRQPPSHQQQQSTTTRHSPITSEQRVNDDTTSPHSEEQQQHNGNKNNDNSSNMATVNSQIAAQRQLPPTAPPPRSQHYSNNYNSNSRAGGNVGGGGYRGRRPVVDEQSQHQHHQMNSGNSANYASANGSHSGSRSMRMPYRSGGGGGMDGQRRSSGGADYWHKNGGAGVGSGQSSGTREDERERRSGGGYFQQRNDRWQPRNHHPNAPPPLSVAQRRARGPLPDWDEVQEVGAEESFDYMDLMENQYSQYYALSSVPPFDPSLSVGVIAAPADANTAAAAFSTGALPNYIQQLQRMALTTFRHPSGYVIAQPPPTLQAAATAAASLHQQQQSSATTTAPQPESGGGGSPPESAAMALQQPLNILAHPTAAVPSATTAAAHANVVVSSSVPPASLLSPTGLISFPLASPTALHPNAVMVATAEQIPPTTAAAQFTSAVLSAQFPPNALFTARPPAAAPYIDEMKLKDLVRAQIEYYFSADNLQKDFFLRRKMDHEGFLPLSLVASFPRVRSLTLDQSFIVKSLRDSEKVEMNEDDQKIRPRMNPQHWPLLESATHTGTENSPTTATGAEKSIIHPSEPHEKRANETDKEDLEPEQQQKQLHRNLLRTTEVEQQQLNKEKEGQTKEGLSSDVSQGSSTSNARQNESAAVSVADSGKEKPKGVQQEEWKEVRTKRSKRSNRNSAYSKQSAGVELDFQFDSEIESGGNAADVGEATSEDRRNCDDLDDALCNKLIIVTQTPPSSSSSGKKGTDVRKMDEKLNKEMEHTLRRYEQELWSSKATPQQNDGNNGQRLTDVTTKERPFEEDKQIGQEEGSLAFNVWTKKAMERAAASASIPKSPVAKREENDKPVKRFYPLSLHERQQPFGKPSKSKESTRQMQVMPIGWVLGVRSKNASINEDAGGPGYPSTSEPPTIKPPPIVGVFPPHPSVSLFQENGFEQRVYTEWRTQCKKQREALGYDIPEMNTLYRFWSLFLRDNFNRSMYSEFRKFALEDAEHGLRYGIESLFRFYSYGLEKKMRPKLYNDFQETTLQDIKRGHTFGLEKFLAFLKYCKYSTQLEVKQQIAKELAKYRANELYATEPAKAAKLELQNESKVGNGRNAMVGATGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I262</accession>
    <name>A0A914I262_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I262"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5918.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5918.t2"/>
        <property type="gene ID" value="Gr19_v10_g5918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5918.t2"/>
        </source>
    </evidence>
    <sequence length="835" mass="92348" checksum="C5E386730990C4CD" modified="2023-02-22" version="1">MIGRADIEGSKSDVAMDAWPPQASYPCGHLRYALTDVPPQSNSPPDTVIGAGRRATGWHRLNTKKDTLAGALPFYRLTPTEVHTLTSIHAAEALHKQLSPLVHAPPRKETARSHGQKPPVSHNSPADPTFRANSFPERLFTLETCCGYRYDQAGDSYRFSSHFQGPCGAHETPQEPRHARPKPEKRTLARTPHDVCEFICVTARNSSCEPSFPWPGVGMLTHFPFGNRMDKLRKHSKDRLTHIQLLFTWNPSPLQSSRISLEYLLLPPRSALVEAPAGPTPKAFNATTTTLLHVMARLSTAVAYKPMTAEYSGFRLPWPPSCCLYQPTPFMGSNERALWHLNSTFGSSHIASSAYQKWPTWSSNIQRRDDRFARQNRFGLPPEFPLASSCSGIVHHLSGLSAYALSPPHRMRSGRDYVAPAHRGARDHTSAPQGDLHFHYALGTELTAGTCRTRPPPTASSNQHGPVAIAHTQHPEQTALPQPGCSEHLSALRLQMLHEPLNRMNTIPVWRVAIQTPKNTRMNADQIRQLCPFPSHRFHVLFNSLFKVLCNFPSRYLFAIGLVAVFNTRRWIGNHSLDRSCTFSGAPVKGNLNKQANPSSRSVRYTSRPQRRSDSALDSSQFTRRYYGNPLCKNTPKRDLSKKTRTCSAFFGYDPEPGVPMDVTPMAQCAFESSVFKVSAVHTNYRSWLRSSSIHEPSTGPNTSSHHGHGRSTQAQTCRKAQQPLNDAQTPAQPLGCPVGVLPPLAQRPDDSSNRRLTHRATNIGYTPTLMCPQGAVRTLLVNVPAHTQRACVRQQQTEACGVAHTDSMGVRETLLGSWVGGCTGELGGLSEQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2P3</accession>
    <name>A0A914I2P3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2P3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6291.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6291.t1"/>
        <property type="gene ID" value="Gr19_v10_g6291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6291.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10381" checksum="48F82D7FEA9E7A1D" modified="2023-02-22" version="1">MNVQRFFAYGQFFTVNESVAAIFSNIANTVLRYEIRLQRHIGGVYTATVSMPIFCITVLAFVAMTESNARRSLLWLSRSALICLDFSSCNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2T0</accession>
    <name>A0A914I2T0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Importin subunit alpha</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2T0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6338.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6338.t1"/>
        <property type="gene ID" value="Gr19_v10_g6338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548614" evidence="1">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6338.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10796" checksum="2FC4076DA7DC13EE" modified="2023-02-22" version="1">MKMILLMFNAVLLLPIIFAMPNPISLLNSETDSNATNTNIQLVNQAKSLDPNERFAAVSRICGLLWKDAKENEVAIAEFVSIGAVPVLVNCLKSTEFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4U2</accession>
    <name>A0A914I4U2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4U2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6623.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6623.t1"/>
        <property type="gene ID" value="Gr19_v10_g6623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037102931" evidence="2">
        <location>
            <begin position="26"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="100"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6623.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33450" checksum="4B0AFFC103D288A4" modified="2023-02-22" version="1">MRFFHFLDAVCLFVVAAFILLETDASPKKSTSNTNLENEPAEQKNPGLTPENQWNSDACHEHLTLSEHVQPSDFKLSKPKEQPSVLKLSKFKEWVVNHNKKKSKLSQRNSDANEHHPPHLTLSEPVQPSDSKLSKPKRLLVVKHKKEKSQWSSVFAVQPIPKTSSGTFYYEVSILGKAKTSFISIGLCTNKMPLDSEIGHFKGTYSYQSFGAFTADSESSMKVGNGEAIPFISAGKVVGCGVDFKNKNELFYTMDGKRLGPTGKFVTSDDDLFSCITLSEFGDEIEANFGPKFVYDIADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I514</accession>
    <name>A0A914I514_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I514"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6952.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6952.t1"/>
        <property type="gene ID" value="Gr19_v10_g6952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000345">
        <property type="entry name" value="Zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6952.t1"/>
        </source>
    </evidence>
    <sequence length="658" mass="71411" checksum="0290DBCF47D2B8DC" modified="2023-02-22" version="1">MVDFLPPVVKLKGIILSPDFLRDKTNFCCWRRLMKFETASAAAAVPSGEAMGAWPLAKICARREGGRIWRAVISSSPPAKRGSQSAPPLGRSRRTLKGAEWGESATTIAAAFGTYLSTKVDGSVQWQTLKPSKWPHSINRLLLTTKRRDKEMFKSRSTGGGAPAKENAGRGIANEAKSAEPNNGDAISGEHCGAMATAFFLQQKLLLAAAALAGQAGHSSAAAPIHQPPPAMPSPSPLFFAGCRTSSSSASWVPPDSVHHQPPPLLAFPALFAYGGAQPHNANALHHLLHQPNFPQRLGPSATLPGHFPPLAAHHLQQPFNGQNSAQQAFFAALLQQHFFAQQLRQSLGNQLPVENAFAIPSTEQHVAVQLASNGNNAGGGGSGGSEAGGSNSKNERNRTQQQNKPKKKISAANIASKENRSAKQNSAIKVKQEMDGPNNDNRTNSTPPTNGRHFECAQCGKCFKRSSTLSTHLLIHSDTRPYPCEHCGKRFHQKSDMKKHTYIHTGEKPHICAVCSKAFSQSSNLITHTRKHTGYKPFSCDYCDRTFQRKVDRRRHMEMHHGGMPITEEVRAPRGVKKVVQHKKEKADSEETMPEDPLPPSGEPTNSLNGQVAECAQSIFQRLGIDQLLAQLSSSSEGAKSLSSVKPEELFEQKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5E2</accession>
    <name>A0A914I5E2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914I5E2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7677.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7677.t1"/>
        <property type="gene ID" value="Gr19_v10_g7677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1130">
        <property type="entry name" value="Rab geranylgeranyltransferase alpha-subunit, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7677.t1"/>
        </source>
    </evidence>
    <sequence length="602" mass="68417" checksum="3441B9B854E613C5" modified="2023-02-22" version="1">MHFVKRTPFKQSDEQKEAEKRKQATKLQQFIYSRDLVFRKRKLGEYDDEMLNLCGELLKKNPDIYTLWNVRREAIEQRSKKNVHESDEEFTTNFTKLLDGELKLTQDCLLQNPKSYSTWHHRYWACLRHPVPNLRRELALCEKALAEDCRNFHCWDHRRSVARMAKLSAEEELSFSDSLVGRNPSNYSAWHYRGTLLPLVRPNTDDDRPEAVISDQCLAEEMQKILSVCGVNSDDQTGWTYCRWLVGLATAQNFGQNVEKLVSLTHFDMDMALLVFSEAVDAATVMSKLDGNTTEALKLHSLSPFSAPLQSAKWHRAHVWLVSGGLSFTPSAGVFRAGCPRFVNTGFLATYFSPSASCTRTLPQEALNSLVSMCEELIAAENNPWEVSALTGARLALDGITKETVKLVEQNCEKLKQFDPQRAAMYGEKFDTIRIVHEITKNVSEPSNQNQLDLLLEAKSDRLTLSGIGLINLTNLRLLSGVVQELNLQDNQITSDQITQLCTFAALTCLTLDGNPIDGLPLIKPHWFPRLEFLSLARTRIAQASTFRPALASGAFSALQRLVLCETPLANSESERMELHMLVEQRTKEEQSKVRLIMDWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5I4</accession>
    <name>A0A914I5I4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5I4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6970.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6970.t1"/>
        <property type="gene ID" value="Gr19_v10_g6970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6970.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31683" checksum="8382B00E4A75591E" modified="2023-02-22" version="1">MLHGEQSSDCNGWNKKDNGGRGDDGMAETPGEQKTMLEDHAQRDGQQCQAVVEAPLLEVPFGGEKNVNDDGLTDDYGINNHSNKHNSWHGTAFTEVSFRGEEHVQMIVYDDGLTYGINNKSRHCTAFTEDALSVTSCPGAISLFFLGIFYGWLIFAETLRFGVRRFYAANVFCALLSLSLGAARFKQMDSELDSAKTTTADGGTWWIWATAVLLLLLLLLLVGGGLAFVVWKKRRQSAPTVPAITVEVPADENEIEMTEMAAAPTRRWEAYPGAWNTATGSFKGGQALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6Q5</accession>
    <name>A0A914I6Q5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6Q5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8010.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8010.t1"/>
        <property type="gene ID" value="Gr19_v10_g8010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000160">
        <property type="entry name" value="Titin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000056">
        <property type="entry name" value="twitchin isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000051">
        <property type="entry name" value="Uncharacterized protein, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF151">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="84"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="189"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="287"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="385"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8010.t1"/>
        </source>
    </evidence>
    <sequence length="621" mass="68634" checksum="5AD14DDDF4585F97" modified="2023-02-22" version="1">MNSDDSEDKRRLFEYFIVAGLNDESGCPKELSSMSTAQPSSADVGKQTHHYQLAPITDICVIFTSPGETATADFDRIETTPQDYPADLNHGSGKRPPHTFYKIPKNQQAEVGGAPIAGYVVEKLDTATGRWVKAGRTDGPDTKQFTVDGLQPGYEYKFRVSAVNRYGESDPLEASKSVVAKDPFETADRPGTPDIVDWDKNWADLKWTPPTDDGGAPLEKYVVEKRMGNGEWEYATEVPTSKTGARVDGLVEGKQYQFRVKGVNKAGESAPSNPSRTLLAKARRLAPTIDRSAMPEIRIKKGGTIEFNVPVEGEPGPKCQWLINGTQLGTSDRTKVDNSNKNNTKLRTLGAERMDSGTYKLIATNEHGQDEADVLVVVLDVPRAPNGPLEARDVTNDSATVNWYTPDDDGGSPITHYAVERQEGDGGRWVPCGEMPDTQLRVNRLVEGKAYKFRVKAVNRQGESKPLAMERSVVAKNPWETPGKPQDVKVVDWDKDHMDLEWKAPVTDGGAPIDGYVIEKKTKTGPWIPCAQIMVGWHQHCPEDHRMKLVFVLSICVLFGVMFGLGEAHYYGGYGSYWPSMYGSYGYGYGGGWGGWPYYGYGYYGKRSVGFEPGEEKSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6R5</accession>
    <name>A0A914I6R5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g7144.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7144.t1"/>
        <property type="gene ID" value="Gr19_v10_g7144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000015">
        <property type="entry name" value="Nuclear receptor subfamily 2, group C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="382"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1257"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1405"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1193"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1257"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1405"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7144.t1"/>
        </source>
    </evidence>
    <sequence length="1451" mass="152941" checksum="CC15576B9BAAD0E2" modified="2023-02-22" version="1">MDGGDDVLFAAVVTDDVRTAQRGSRFETWSDLLGALKQTHIAPAPVGAPAALLLIFAASAFRNGTHQAGRSCLGRGALSGRMSTTTASAPLATAASLGNLMDHRATAASVVRSAAGGIDVSSSAVFPRSSTASAFLPPAAAAANSAAFHAAGQYSAAAIKRPLSGLASLPPLLHASTEPNGRRSSPTAALAAPPSSSLQPPPPPPSHALNGLLTLHQQLAIAQQQQQQQQQKHQQQMGFAAAAAQQLAVSGLASPANLVAMMQAVNNLRLHQQQQAVQRAQQQQQQQSNQQNPFVALEQLRTAGGLDQKLDQKHFMSPQQQHHLVTKQPIGPFVAGLSHSAGSNMAGGGAGGVPPKLELNKDSSAAGSPTSVNGCGSTIGSGELCVVCGDKASGRHYGAISCEGCKGFFKRSIRKQIAYVCRGSKDCPVTKFHRNRCQFCRLKKCLSTGMKSESVQAERRPMNAAMVAAAAAVAASSVSMTSTDVPSTLPPAVPGGRFSSAGSMSTNIRHHHRQGGPASSATSAASEFSSAFGHSSGSAFMAPPTMVSASASFGPNAFQSVNALAASLYRQQQQLHQHNNNNNNNKRGGSPLGNGAAAELLQHQGGATKRKRLNTGDAPPARNLQSPEHLLTQSSTYSNLQQGLLAFVNRHHQLQQQQIAANNSVDDIRFHQTQQQQPSVVQHHSILVDTSSGSDSGGTTDALALHHHHHHVQLGKRCSSPPHSSSDNDATSSSALVDICGNGGTVVVAARDSHGSPSLLKPALISSNSSVGTGGGPIGLHGSLSPPITSQSPSPPTAMAGTMVNAAGGISANNNNNNNNDASLLAQLLKRDFAFSNQAHQQETTAGDNIVVDTLDGHHADPLLLLELDDSPTASSRGSSAFSVDGAALNNGTGSSSSPPLPALQSPVISAQCAKFELPIPPQLDAQQTPLQQQQQQQSAVTGGVDLGFICESASRLLFLSVHWVKGIRALADQHTLMESTMKGKWCDLFVLGLVQCAHELNLPHMLRTVNAHLCARCRYGQLKWERYEELCRQIALLHLFAQKTRQLKLSGMEFAYLKAIAFTGADLPPRAQHTQLVRQLSLHTGHGAAQLRQLNSLTCQELFEHIVQSQLVRSFGDADTVKRRRRHFCCRKKKAANFDLLETTTTAAAASGGECCADGGSDCCGASSTTAGTATTTTTTTEGGGGGGGADQRSDGTCEKSDECRSSGGERKEDSGNGDEQHELDADGTLILCCDTTTSPGSSASQQQTIVVVTHKREDDGDVASRKAKEQRIKSDVMTDNEEQQHHHTLRGGELGPEEMLVAVERHSLLLQLLPCLRWFNEATLVELFFSTLLGSISIETVIPFILNTNTETIFERNGAVNCTSVSGGEQGGGGRQQAVTGQSAVAAAASLSMSLTLGHVKLEQDDDRHHAEKSDEVEQDDYKHQQQRNRRHSSSSNSSSDRWMNVNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7F6</accession>
    <name>A0A914I7F6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7F6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7992.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7992.t2"/>
        <property type="gene ID" value="Gr19_v10_g7992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039934">
        <property type="entry name" value="C2CD2/C2CD2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119:SF5">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7992.t2"/>
        </source>
    </evidence>
    <sequence length="948" mass="108427" checksum="1D09DB9652982246" modified="2023-02-22" version="1">MDGLIWIFVAWLAVAIFSFYVFIHRRSTIPKVPTIQIDDDSSFTLETQHGFANDLLNWVLWGNSGTTLGMEQRLALSPVLAKFVLVSLNEAARRIDKEAAPIELQFDHMSRQSVDSEGIQLRSKESMFRNIHIQQNESPGNYLSIHTQLFYAQESADGGIMLNISASNDDQRTKSVQQDRVHMRKIPVKRGPSIKRHTVIIEQINGEVEIRLAFIAGELFVISCFKDRPTVQLRMTGTAKADEMLSYVKRCIISAVLNFSIGELLYPDTESTERASKARLSSEYRNLSFLHELYPSPQTPTQQKVSPRSMLPKFPIFVKDIRPEELASANRLKIQLVEIYGVNFEFDQQPFVCIELDEPNQRLLSVKADHQGHRPDGHKVYWDEHRASFEFSVSSASNELLFEVFFEEEQQAKLGSPNNIRERKFCGTAIQSLAELRQALQEQRQTIELRLQGRPFSYGERSRQSSQHQQQQEVYGVLVIKAFLYTYHEIERPSAPQPIERGVVEIVENCLQTRQPKSSSPFAYPGDQPPPLSPIKKHSTTGSESSSTIKRTKMRQKQHYIYNVTDDEGQSPSYDRQYAVGSSSSPDPYKTSTSLKQFEYQSTNNVNVEQQQSPRPVGAVRKTISDRNALFQYEPYEKTVVERKKSAPITKMSSSVTNTEQEKKMITKTETQPTQKQSVKDEVSNPNDFEQLFDKQKKLSEQKQQEQGGHPAMAIFEMPDKMKRLTVGNDPEEFERIARERDRKTEPKKRGRSFFEQVRARLAGPVRLLPGRDGKRAKSYDDNESRPMEEVAASTPTSRDQSQTRHIRQRKGSDHFEPMYNQQLFVNIENSIGGSAHQSTSNLIHSPKNVFENGQSQLVLELIGTEEEKPRYYSMPPEVQSEPAVIKLMQSGKKLHIYEGHIFVAVKPRGRVICALPSEDNMDVYKQQHFQHEYRGSGLARILEAQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7J4</accession>
    <name>A0A914I7J4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7J4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7479.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7479.t2"/>
        <property type="gene ID" value="Gr19_v10_g7479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7479.t2"/>
        </source>
    </evidence>
    <sequence length="680" mass="74719" checksum="3CA7C120BB861EDA" modified="2023-02-22" version="1">MTFGGSDIPAGSTMSLGPLFPSSAPATSSPLTAPPSSRPSVLRQFRSLTSLNSAGSTTEALTALERTTLGPEPPPFAAPYGPVPVDDDDGGGNGQPSASGTDGTKEMPCHRRTDWRSLYVASFLSFCTVVQFSLYFSSMWPYLEVLDKNATESFFGYIVASYSLGQILGSPIVGFLSNRMHKIRYLLYVGLLLMFCGNGLYLSVHLFRSAERKYLLCVARFITGIGSSNISLLKAYASTASTQRDRARAIAFVTGGVALGSTMGPAFQLLFTPFGYPGIRLFGLRNFSVSMYTAPAFMACAMNCVNAVCIRTMFAENYVGVHAEQQQKSDASTADNDDNSASKLPPYDRRAALLCYGTRFTQMFVNTNLETLGAPLAMMMFAWTRADAVKYISIAQVAMSLLAFLTYVVFIVFRVDKVLSDRTNLVMSLVVLITFHVLTYSYPFLPGHVQTFRHRDLRNHSIPEPVGCDIDKFTWCDTVRPIHPVYFYICYVFCIGLAFPNINVSLNTLFSKVIGPRRQGTQQGVLQMSGGFARMLGPVLISSLYTSYGPQSAWMVELTVVSATLALWMMLFGRMVPLRLPSESVVQHPQQQHQQFEGPKAVVPSSTMSETRAISDQPLATTSSAVTTSRRRIRSLRSREERMPLVEPIDEGDEARTDMEDGAVVLNRNDTTVSTMASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8E2</accession>
    <name>A0A914I8E2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I8E2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7855.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7855.t2"/>
        <property type="gene ID" value="Gr19_v10_g7855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7855.t2"/>
        </source>
    </evidence>
    <sequence length="441" mass="48804" checksum="ED343920154F41F6" modified="2023-02-22" version="1">MNSRPRGRGRGAIRPSASPFAWASTPPTTSTTSSISRRVIVPNFAAAGRLVEPKAEPKTEITSPAGKEANTSKSNHVNNRGHNRGRGRPKAKGTLQREEQRIIKSEGVFSQGFGDADVSGKRSKLKNIKGDETVVGHLENSINCVGRDFKTEIEDKKEVLKRAPKRENGTLNAYEEHWQSDEEVDKEELDELFRDGFISNLKKCSKMPFVLPSKDEAQFRKLVNKKERREEHMDELMESERKDTQLVNKTHEAKFFAAGDLLQHAISGEGANSIMFFQLPPTSLRTVSADSLQPDLSQTVTASNPPNLTKTQRHCLDGMPTGVQIGKLQFYRSGRVMMNIGGQQMDIAEAIQSNCYEALLRIETESLSQPSASLPTTSLTGTQHKRQFPELNSGAPFVNPSTAFARPSNRIANNAQLLGEVSGQFVCLFDVQRSSIDNGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8E6</accession>
    <name>A0A914I8E6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8E6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g824.t1">
        <property type="protein sequence ID" value="Gr19_v10_g824.t1"/>
        <property type="gene ID" value="Gr19_v10_g824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g824.t1"/>
        </source>
    </evidence>
    <sequence length="1273" mass="148250" checksum="921E2B42A30E8032" modified="2023-02-22" version="1">MAPKRQNEQFLEESQKPNFGDSSKENNGPRKFKQEKPENDVIILDDDEEDRKPLVEKSGPSKRGRKPRWDKQQQEPEELPPRKIRANESEEKSQPSVFDYPTIFWKLARPKYGTFTFMCKDCQNANFLLGDRRFVLAPQNGDGRLEFTQTFCRDCAKLNFDCTDLIMKHQKKLAPTKNGHYHPYTGGNWATVGTLEKQYVIVHLRDGRKYRFRVPSGSFLSPQQLERGIHHGMIAEMERLMTRKRAALVEEEGELFDLEVVEEEQGVEPPVEAPLLPLRNETAAKERERAQKEQKERLAYEKENDRLRRLEEDRKEKERLQRVEEDRKEKERLQRVEEDRKEKDRLENERKAKRQKWLEDGRKETERQRQEAARKEIERLQRIENATNENERKEKERKENERKEKERKENERKENERKEKEWKENERKENERKENERKENERKENELKESERVGKLKQESASQDKNKEEERMRRDQERKIKLRELELLKELKPYRGGWMRLVQGKDPTPDVHYLHEKDEYHFANAVDKYRIYHPELPWDLPAFNPSAQIQRNIAEFKGLFEREVYDENYGSKTREEKEELLVLVKGFRFYYMEDIGRFMLKIFDNKISHITLTDQLAYVLGYEQEQQILNEDLAKYSVDLGGGVSHLCIYLNSGIIESMIFGNTFANLLQVIAVEGKSGSVVEKDFQTPLFHKIIAREVDVLDVEIRTLTGREVPFDFGQVVLTLQFKKFYQQTGSGPIAYFEGLPTFQRGYGYFLGVPRQKGAGVGAVLRNLWRYLRPMISAAKPYAANIATELGKEGLETGARVLSQVSKGGDIKEALLAEGKEGAKKLLDKASSSLQKGRGKRKRRGKKTKAEIILKPFDVIHPITSYIDLSKVFVFTEFKIKKIAEDGLLNNIGSSDSVGLIQMPGATFIRNLKVHINQREVYDSNQLYSYKVYLDTELSYPIAAKDAYFGVAGYFRYTDLSKANDKRRKPLAESKAYQTISKLSADIFNQDLYMISNVEIDIELALQSDDFMLHQEKEKDKFVLEISDCRLIVKTVDLMDGLSLDIARKLDVEPARFGIRKSFMKSLFITGGRYDFSANLFTEEVPRRVIIGLVANQNYIGHKQKNPFFFNHHNVRDIELTASGRTYPQYPYNLDYKNNNYARAYHDAQEHLGLACTTESNGLSYSMFKTAFCLYVFQMTNSQEDSPGFELIKEGCTAGLQPLGFICSCEKGEFGAKMDNRFIDKILFENPATRKFFMGTFPSDGPSWQAGFSLVRDLGQVTNRGLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8T5</accession>
    <name>A0A914I8T5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8T5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8341.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8341.t1"/>
        <property type="gene ID" value="Gr19_v10_g8341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.140">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8341.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12925" checksum="2F55A7509AA640DE" modified="2023-02-22" version="1">MLIAFAAPARLLSSRHAIAACRHYSAAVLDPHDQLKDSDKPMYEQMNPSFNKMVDDYFDKGAAVIESKIVESIKSRSKSLEEKTSSVKGILAAIKPVNKCLIISTWNCCTRIDDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8T7</accession>
    <name>A0A914I8T7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8T7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7965.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7965.t1"/>
        <property type="gene ID" value="Gr19_v10_g7965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7965.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="42134" checksum="C2619BD56EBBE9D7" modified="2023-02-22" version="1">MSDNVSDEEQQQQMEEISICADVWLEIFAFVSPLQLGHLMALISDRFDILVDEHFKLRKWSLSWMDIRRATDGNGAQFVNCSGEQLPIPQGPLPNKVIGFKHIGISYVDQTVIEFLQRIRRLFDSAETNVFIATFDDESRSWEIIRQKIWPLINDNICRFLLFHSSVLDNLRQFSPTVLRNCAKLRLTDSFQHFPEFPAEDNAGASSEQALAKWLITAREDALQDDDLPPILDGPFSPARNEGPAETNYSDGVKPFRLADCLQILERVARDYDCIYPLPKLGTKRDHHVGCCLLIRSLSSANRLYIFEWQECIELKGHLEMEDGSSKRVLHEFYEKYDSLEGFNRFLRECLFNFFYLLYSAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAL0</accession>
    <name>A0A914IAL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8130.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8130.t2"/>
        <property type="gene ID" value="Gr19_v10_g8130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="47"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8130.t2"/>
        </source>
    </evidence>
    <sequence length="217" mass="23553" checksum="3A3BF618FAA662A6" modified="2023-02-22" version="1">MTHPIEAATTVYTEQLSNEVEKIRIADAVSNRPSQRVIRSPIVLERGVSGRVKWFDFWKGYGFITRDDGGQDVFLHASAIVRKVKMHFVLIEGQKLEFDIIDGEKGREAAVVSGPGGMRVGTAIQYNPQQQLGGGKNIKRMISAGRFMRPAGKNTKDKAVVVDGSDGIKGSRSVVGTRNGRRNPKSKKTVMGERGHDANAGDAKGAQKSVSTDDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAX0</accession>
    <name>A0A914IAX0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 17">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="17">GNT-I</shortName>
            <shortName evidence="17">GlcNAc-T I</shortName>
            <ecNumber evidence="14 17">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 17">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="17">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Golgi apparatus membrane</location>
            <topology evidence="1 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="14 17"/>
    <dbReference type="AlphaFoldDB" id="A0A914IAX0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8903.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8903.t1"/>
        <property type="gene ID" value="Gr19_v10_g8903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000252">
        <property type="entry name" value="Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.20">
        <property type="entry name" value="N-Acetylglucosaminyltransferase I, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8903.t1"/>
        </source>
    </evidence>
    <sequence length="419" mass="48877" checksum="0C81450677A96448" modified="2023-02-22" version="1">MHYSLRQLNKDGLNLDVQNRAADFLEQRLDQLEDLLRNEQRELGELSRRIDAKKIAWQHPIPVLVFVCNRLEAARAHLQKLIRYRRYQKELFPIIVSQDCDNKALQEMVQREFGSEVQHVKHISSESARLKPPPEHRQFSTYYKIARHYKLGLTHVFDNVNFTSVIITEDDLDVAPDFFDFFLATRPLLEVDRSLFCVSAWNDNGKKGLVDLSFGPSLLYRSDFFPGLGWMITRHFWEELRPKWPRAFWDDFLREPEQRKNRSCIRPEISRTAMTEFGRIGASKGLFFNRHLKRIFLNQITVNFTRLDLGSLQQQRYDDKFLGRVYSAPKIGIKNILAWSKSGGGDHRIEYASMDDFVTVALKVGIMADSKAGVPRTAYRGIVTCFLNGTRLFIAPPQKWNGYDRKWEAPRSILDGMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBV5</accession>
    <name>A0A914IBV5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBV5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9404.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9404.t1"/>
        <property type="gene ID" value="Gr19_v10_g9404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037019988" evidence="1">
        <location>
            <begin position="21"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9404.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="22692" checksum="72346B006D33D79A" modified="2023-02-22" version="1">MNFIVLFIGTLMLLFNSSVALRCLRNTIGVLPGSDSRLDLSGKECPYVSKYDSCDPNNPGNNFCYAANCYKNGNAKEWITHYECTTSLSPTQCGQNLEKRLQRIFGGPMKCSACSQGGFKIDMANKKFALCNGTDSCTVQPAVAVEVAPKETTTPPARLPSTTPPARLSSTTTFDIIPLPPDAGTTGVHNIALPAIVIGSLASVLCCVFGPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICW8</accession>
    <name>A0A914ICW8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914ICW8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8753.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8753.t1"/>
        <property type="gene ID" value="Gr19_v10_g8753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="183"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="389"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8753.t1"/>
        </source>
    </evidence>
    <sequence length="804" mass="91603" checksum="D478D8A731BF3208" modified="2023-02-22" version="1">MEFGDRDSQTDRDTPPVQQMSDPGPDHRINRKKLENIERLQRKNEAKISKNKAKKLAQLSARKRIKQTRESLFEMLQQYQLDNGSMNLLTSIAGNKKENCNQKQKSEVVRKLRNSAITSKLTAVHAKKICLRRMSNNRIGLKTQKSDQPAEKNPVQNASTKMDAKLLFNERKALKVKAINENPAGYTSNGHLIGVTEPRRIAAISMASRVGYELHDSKVASYQIRYEGNQKLQVDFTLSRYSVIVIDEAHERSIYSDVLIGLLSRICVVRMKRGYPLKLIIMSATLRLQDFLRQRLFSNIQPKVINVEARQFPVTIYFERRTPNNYLEAVFKKVCKIHEEYPAGGILVFVTGQREVDHLVKLLGSKYRRTPSSSVKKRQPKKHCRDHEEHDNKIEEAEEQMVFDNDEFGTCDMDDGNDEQNDGILGAMHPFNTEQPSTSSLFDKCPPLLPIPLYSLLPVHLQQRVFRETPEDGSRICVISTNVAETSLTIPNVRYVIDCGKEKRREYDPASADQRTGRAGRVQSGYAFRLYSSAVYEDMRDYSAPEILNKPIDQLILMLKAMNFTKMDNFPFPTPPKLDQIKSAELRLTQLGALKAQQNGLLNITPLGQSLAQLPLAPAFAKVVVSSVRDGLLPYSVTLEEGGTDETRKSVSEMVKQRRLWCAIGEARLFGDLTVILNIVGAADYARENESAVKALGLRSKALKEINKQRNQMDPPSQEQLRKLRHIMVKCLPDKLAKKDSSPDAPKGAYKTQQLKDYVFIDENSVLYMEQPDYVLYQEIVQLENKKCLKHLSFVEPEWIPNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEB3</accession>
    <name>A0A914IEB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9107.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9107.t1"/>
        <property type="gene ID" value="Gr19_v10_g9107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9107.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="20253" checksum="C7758888B396CDC0" modified="2023-02-22" version="1">MSVNVPLKQTHPFNLFPETNAMMSSTTVLISLVLTVLASAFVVQADNAGSSHELINRIKRNSYGYSGYGYGGSCYSCCSSCYPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPAPCTTCGVSGYGTTWNNGGSAAAASAAAASNGGSSAASASAAASSGGYGGYGGYGGYGGYGGCSSCGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF38</accession>
    <name>A0A914IF38_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IF38"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9330.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9330.t1"/>
        <property type="gene ID" value="Gr19_v10_g9330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF6">
        <property type="entry name" value="TPM_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037984915" evidence="1">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9330.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27314" checksum="F2A1EEC3519B3915" modified="2023-02-22" version="1">MSLIIGCLLIIVHFCNASFLVTDYPNPLNKATLWKCGISSVGTLCDPDSLLNNTARQEALELLKQFKDQTDINNNGDGTCKSKGVTIGLALTRQPITARNARINVTDDLMKNIWKLDTQCNKALMLTLSINPNPVVRFTRYMTTPVFDDELHHMIWTEMHWLRERNYIMWTQHVEQPAAGAVTKELRRLWLRHFLLFYRCPVFRCCHTERAMDVAPVPPTLWALGWKAGAVSGNEQEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGC6</accession>
    <name>A0A914IGC6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IGC6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9652.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9652.t1"/>
        <property type="gene ID" value="Gr19_v10_g9652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9652.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10096" checksum="5B0BC93BE143FA03" modified="2023-02-22" version="1">MECQSSENLKSYQPTFMANAIGRLGAAYFSVGHFGAACAVILALNNLGAGLLALLISGVSHFGAGRFGILALNNLGAGLLALLISGLAISALVVSAFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IHL5</accession>
    <name>A0A914IHL5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H oxidase (H2O2-forming)</fullName>
            <ecNumber evidence="3">1.6.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>NADH + O2 + H(+) = H2O2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11264"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9992.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9992.t1"/>
        <property type="gene ID" value="Gr19_v10_g9992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042335">
        <property type="term" value="P:cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042303">
        <property type="term" value="P:molting cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009886">
        <property type="term" value="P:post-embryonic animal morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09820">
        <property type="entry name" value="dual_peroxidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000195">
        <property type="entry name" value="DUal OXidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000020">
        <property type="entry name" value="Dual oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000004">
        <property type="entry name" value="Dual oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034821">
        <property type="entry name" value="DUOX_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF144">
        <property type="entry name" value="NAD(P)H OXIDASE (H2O2-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0349">Heme</keyword>
    <keyword evidence="15" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="18" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1081"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1142"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1178"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1207"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="870"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="1228"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9992.t1"/>
        </source>
    </evidence>
    <sequence length="1515" mass="173230" checksum="D262FBD00DD5D8FF" modified="2023-02-22" version="1">MAFAVLFVQIHGLERVTEYQRYDGWFNNLANPQWGSVGSRLHRDAPSNYEDGVYRLDASLPSARAISELMFKGPSGRPSSRNLTTMFAFFSQVVAYEIMQSTQNSCPLEMHKIPVERCDPVFDKACEGKTDIPFTRAKYDKTTGHGLNSPREQINERTSWIDASFLYSTQEPWVAALRSFENGTMLEGMAGYPPFNGQHHIPLINPPPPQIHRLMNPERLFILGDPRINENPGLLSFGLILFRWHNMQARRLQKEFPSWTDEELFQGARRLVIATLQNIVLYEFLPALLGRPRAGIPPYRGYNPHVPPGISHSFATNAFRFPHTLVPPALLLRKRIAGRCEFRREVGGFPALRLCQNWWNAQDIVREYTVDEIVLGMASQIAEDEDHIVVEDLRDFIFGPMHFTRLDVVSSSIMRGRDNGVPGYNQLRAIYGLKARDWDTINVKLNRSEPKKVSELARYYDHNIDRLDAYVGGMLEADGNGPGELFSEIIFDQFIRLRDSDRFWFENAQSGIFTEREISFIRRITLRDIIRQTTSIEKGDIQENVFFWHNGDPCPQPFQVNSTGLESCVPFMRFDHFTGNEVTYIFTCLILATIPIICIGIGYLLIQKRKKMGMLFEPGSNLRKKTPADHHEQNGDLMTMEQQNYSLPAIEWLNEAFCRSVTVELNSTLAQLRVLKRRSGGVLRKLDFKEVHAIGVTVTRKSARARALHAAGMHVRGPFVCIKTPKHYDVVLRLPSEQHWAKLRVALGACMRKHGKSMAEDEADNDVLLEAAETKDKRQAKLDHFFREAYSRAFNMPQLSDHTADFNTYASAQVMNMTLTKAEFAEALGMRANDLFVQRMFACMAHDAQNDTTVTFQEFLEVLRKFTQGSLREKLQLVFDMCDRNREGRVQRQEFCEFVKSLNMAAGVKIGQEVQDHVVESVLHRAGVDPDQEFLTYRDFEAIFSQMDDIRRPVGVHLRGVNLRVNLEETQSLNSFAVTAETEDAFKKNSMSLLLSYLESYRQHIVVLFLFFACNALVFLERFWYYRYENEHRDLRRVMGVGIAITRGAAAALSFDLALILLTVCRNVLTLLRESFVGEYLPLDSAITFHKIVAITAGIFAATHTIGHCVNFYHVATQSQEGIACLFQEAVFGSNFLPSISYWFFGTLTGITGIVLVAVMSIIYVFSAPAVMKRAYHAFRITHLLNVLLYALTILHGLPKLLDSPKFWYIVLGPVIIFIIDRIIGMRKHYKQLRIVDAAILPSDIIYIQFKRPHSFKFRSGQWVRISCPAFSCTFNESHAFSLASAPQAPTLELFIKALGPWTWNLRNELSEAKDNALPYPVVNMSGPYGDGNQEWHNHEVVVMVGGGIGITPYASTLMDLVLERASGNHSGIKCRKVYFLWICPTHKNFEWFVDVLKQVERHDEDGILEIHIFVTQFFHKFDLRTTVLYICEKHFRGDNSGISMFTGLRATNHFGRPNFDSFFKFLQQSRHPEVPEIGVFSCGPAQVNKQIRRACTEANRFRNAPSFVHRFETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPL5</accession>
    <name>A0A914GPL5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPL5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1017.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1017.t1"/>
        <property type="gene ID" value="Gr19_v10_g1017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="159"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="223"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1017.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="41540" checksum="7F9E1680CD6283FB" modified="2023-02-22" version="1">MSEVSAFIGPPPPPPPPPPPLPYSPSSTLCYPGFAQCVFVLPALLANTVLHDVQLEPKAGGKQCANDMLPLHDGVSCSEDAQCQALATGFFCYRGHCCAMPNPSASSYGAACTLAEHCKFANSECSNNICYCRSGYSFNGHECVLQGAAFEPPHAPNLCLPGQVSANGRCYSYVSYGASCEYTGQCNYPGGFCYQRRCVCAPGQLYNGQKCVDDPNIPSNVACPPNQARIGGQCLPLLSLGERCTHDLQCRGKPGEQALICRNGLCSYISKSWDPTPEQRTFPKCRNPSAEVELYSGIPKDCIYQKCSPGYHCEWNSVYKAGQYICCGVGPENPIFGQPKMYPGYSNLPLQCSAINSCPFVDFPYCVNSESFRHKVCCSRAQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQQ4</accession>
    <name>A0A914GQQ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GQQ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1052.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1052.t1"/>
        <property type="gene ID" value="Gr19_v10_g1052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038001286" evidence="2">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1052.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12166" checksum="E640ECF6C7C9EF16" modified="2023-02-22" version="1">MHFKFCLLFFLFATELVAYAQSDWTNLWEGLKTKFSGSNGISQQNSFGQPPNNGQGQFGQNVNGPMNGGGQNPYDQSLQMPPKTEGAGGFFSSLGRKLMNFLAKGGKEDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSS2</accession>
    <name>A0A914GSS2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSS2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10421.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10421.t1"/>
        <property type="gene ID" value="Gr19_v10_g10421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF56">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054272" evidence="5">
        <location>
            <begin position="25"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10421.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18678" checksum="4BCCF1DC311F7061" modified="2023-02-22" version="1">MAFSHLFLLNSLLFLLNFSVPGGAFRLQGVGVKGTLLCNGAFSVHTNAAIFDVDRNPGDADDLLDKGHSDRKGRFVLEGTTRELTNIEPELRILHDCADGIKVGGYAGGDGKDAFGGGGGMFSRLEPCHRLLVIKVPSEYINSGKVHKIFDIGTVDLAEKRQDEQRVCQNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT43</accession>
    <name>A0A914GT43_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT43"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11026.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11026.t1"/>
        <property type="gene ID" value="Gr19_v10_g11026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11026.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="25586" checksum="DC67F9028B0DDC56" modified="2023-02-22" version="1">MSDSGEKDKVSNSGEKDKVSAWGKGQSVRSGENDTVSNSGEKDTVSNSGEKDKVSAVGKRTKCPQWGKGQSVRQWGKGQSVRSGENDTVSNSGEKDKVSAWGKGQSVRSGENDTVSDSGEKDKVSDSGEKDKVSAVGKMTQCPTVGKRTQCPTVGKRTKCPQWGKGQSVRSGEKDKVSDSGEKDKVSAVGKMTQCPTVGKRTKCPLGEKDKVSAVWKRSLVIRNETLHHNIFKQVNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTB7</accession>
    <name>A0A914GTB7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTB7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11080.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11080.t1"/>
        <property type="gene ID" value="Gr19_v10_g11080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11080.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31994" checksum="A706871E51D22A40" modified="2023-02-22" version="1">MSQLNELREHPTDGFAVRGLVGNNIYKWLLVVFGPPDTPYEGGTFMAQLDFPRSYPRHPPTMRFLTDVFHPNVSEIGFVCISILHAPGADPFGVESASERWQSIHTVESIVISVQSMLAEPNFESPANVAASVMYRNEPERYNERLRQCVKLSNETFEQEEQQQDESKRRKADTRVLHVPKLYSPSGVFIVCCVKENSPIVWEPAPVYLAAVLEYLVAEVVELAGKTAQDNNKKRVNPRHLQLAIRNDEELSTLFSGVIISQGGVLPHIQAEVLPKRVFNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTF1</accession>
    <name>A0A914GTF1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GTF1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11103.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11103.t2"/>
        <property type="gene ID" value="Gr19_v10_g11103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF71">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037426266" evidence="12">
        <location>
            <begin position="22"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="13">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11103.t2"/>
        </source>
    </evidence>
    <sequence length="391" mass="44826" checksum="99A52F5520935C8A" modified="2023-02-22" version="1">MIRYLPVLLLLIVQLFECYSSDRIEEKKRQHKELETNIRRLFSTQKAFIPAVLRLRDDELLCKCNHFESCGKTMWPTSLANSTWTNNDGTIREVVTSCVHREQLLSRERPFVCQNITNPQLFQTVTCCKSASFCNDFEFPVELGLAEQAYGSDDDGWSPAPEHLYFLLLFLVSVFFSGLGLCVGIFYPQKVKALFDRLFGWVVSCRCQTLDRLRPRRRNETTASSNSHLDRLMEEATMSTGSGAGAPMLAERTMARRHGALFGSRIFDEHIQPRIVQRVPANGHLRVGTCDLEICRRMSVPTDSVPSFPYQVSYWEYVRREPSPDEMAQCVCVEGRRPSIPVDWSNSKILSELTRIIEESWSAVPQSRLTALHIRCTLDRICAEENVRIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUR4</accession>
    <name>A0A914GUR4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major capsid protein N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUR4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10572.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10572.t2"/>
        <property type="gene ID" value="Gr19_v10_g10572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10572.t2"/>
        </source>
    </evidence>
    <sequence length="252" mass="28464" checksum="BA120651BD8BF06E" modified="2023-02-22" version="1">MQAAPFHKIDRDSGNAVTSALAFFEIPDTDVSLSHSSTVEYLTLNPVNITPYHFKIHASSDYIDLSKCYVFTELRIRKEQGGVMKNLVAADDVSVCQMIGHTLWKNCRMSINGTQVFEGNDLMAYKSVMDYELTYPESVKASYLNVAGYYVDAEDFQLAGNGYNARRALFEESRTAQFIARLDVDPCNQPRYIVNQCEVDIELLPHSSQFVLLAPNAPTTPAEDVRQYHLEMISCKLYVKKAEHGIPCGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV09</accession>
    <name>A0A914GV09_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV09"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11438.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11438.t2"/>
        <property type="gene ID" value="Gr19_v10_g11438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF5">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="530"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11438.t2"/>
        </source>
    </evidence>
    <sequence length="643" mass="70277" checksum="CE38BAA12C85ED56" modified="2023-02-22" version="1">MFSSIYRLIDNLIIDYSLIVGQFVLRLPLRPNDGFSVSSSFFLHLALPSPHTVPSLPAAVTGSSATIPSPSAASPTRDTNALRMPSDPLDFLLCQSNSTKLPATVLVLRLFALHCSLSSSVEFCPSSASCHICRLFRLQPIRFFRNFRSSAAHSHTIVKTTVDECSCWTSSSTWRKQQLLAANRPKCPFTRGKHLPAAATFIVPFYDPHGPPAPPDELFTYTTTIPPPPDELFTYTTTIPPPPDELFTYTTTIPPPPDELFTYTTTIPPPPDELFTYTTTIPPLSPPFPSNEKSFPTLVPPTFPNLERSIDGGSLTEKKEIAEAVLKNAEGLMDGSAGSERGNASTSEGKTMALKLPELMGELEEFGEGMQKGSENGRDSAGEDERGAGTADVRSAHQNGEDQQQVALFESRKCSAHQWNVRVRPHGEGQSQSVSVASRRDVPMPIFVGKGKERQQIIGEESANGKAITAQRGDDQQRSNSELVPGHPFASTALLTRSASSQSTPDQCGVGPNFVPCVPLGQANARILSCCQQKQMPTGCLALCRYDTTQAQMKQAFEKGQCGLLNIAPFLSCASQGQNNVQCCRHREIVKRSGVQYNARVPPRRSSFHNIRPSFALNERISRIHHIFLSSFFGIDSSPIQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV13</accession>
    <name>A0A914GV13_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10658.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10658.t1"/>
        <property type="gene ID" value="Gr19_v10_g10658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037976496" evidence="1">
        <location>
            <begin position="20"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10658.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45422" checksum="0EDDBAE6FEC0D37D" modified="2023-02-22" version="1">MHFSPIILLLFHNLVPSGAFILTPESARQRSSRPKPPAFRRLGHLDDGTAPVITNRNPIVLIPGDGGSRLKANLTGKPSVVHYFCERQTSKYFALWLNLEQFGPFAIDCWADNMHLDFNSSSGKATDLAGVNVRVPGFGHTRTVEWLDASKRSPSRYFAPIVSSLIAWGYRRGVDVVGAPYDWRRTPEELIRYFAKLRSLIEQIFHANGNRKVIVLAHSMGNPLANFFYNKFVDKAWKDTFLLAHISLAGAWGGSAQVVKLFASEANFSQNYTLSNLDKFFADIQYPQGFDQWKSASRALVLDPPGVKVYCIFGIGVDTPEQFEWTHSWFFPDYQPYIRYGDGDGTVNRRSLEVCERWGRTTPEGVAVHRLNGTDHLGILSEPRTLALLRDILVAKGGRGTSEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWP6</accession>
    <name>A0A914GWP6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWP6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11867.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11867.t1"/>
        <property type="gene ID" value="Gr19_v10_g11867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11867.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11266" checksum="B88C3EDF7495774E" modified="2023-02-22" version="1">MAETGESTGKIQVMDALDLGFSKNQYLAKGNRGSLCLDPDLENVLEHDFSQEKSRVAEVPLDLDSGDHGTHTDRQREIIVKIATLSNLPKRVRQNDNSSNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWW8</accession>
    <name>A0A914GWW8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GWW8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11150.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11150.t1"/>
        <property type="gene ID" value="Gr19_v10_g11150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF50">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="96"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="546"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11150.t1"/>
        </source>
    </evidence>
    <sequence length="595" mass="65606" checksum="BFF5A9AB7288D286" modified="2023-02-22" version="1">MSSSLSLSSSPSQQPHLPSLSSVPLLLDMLLLNTSSTTTTTITSTTTISTSITTTMPPLTLSHAALPSPPPPPSSVLHMRLALTITHLLLVSLGSVNLLVIFVILIRPYMRSITNVYMISLCLADFIYLTNLTLVAVTQLNDKSWPFSSVLCTMYHGTETTGKYASVMFVVLLAVDRYCAMCKSSWCSRYRTYRAAVLVSLAAWLFAALAASPLYFFAEVALLRLRSSASFSATDRREVHKLCIAKWPNSDVARWYITISSVLIFALPLAVIIFCYYHILNKLREALKSCKRMKRGASSRAPYHRVTRLVLWVVVFHVLSWSPFWLFNLFSSIFRLRISTQFDRIVVNIIHLFPYVNCALNPILYVAHAENFRLAFRSLFCGKFLGRRHDELFDGSRTIVPGTNGFTLATAQCRGRTFSVQTTDIRPMFKQLTAAVGGPGPGGAGSAPSLLLDCPKLPLRANSAKHSVITLESSGAEPTGGVRRREPRTERHQQGHVCEQTTALCTSGVGGGTEAPAALFSSNSVPFVSRVINAARPAQKRSLIVGKSPPIPLHRSNTGDQMPREKRKAEEKISLGAEEEEADEWIMGEEGDEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYP0</accession>
    <name>A0A914GYP0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYP0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11615.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11615.t1"/>
        <property type="gene ID" value="Gr19_v10_g11615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11615.t1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38759" checksum="53A757EA5B4693F1" modified="2023-02-22" version="1">MRNLLLLLSSSSSSSWPTTIVLLLFHVSASVAAGAGAITPIPMELLNPRLTEFRRIDSSGDDQITFSEFLLSDRPWMETISRRFHSIDANSDGKVTRKEFETFFRGKDEEQDRQRNHQADGFFKQLTFQALALNRGHCTDPARMGAPKCFYCNCFATGKYSINYLMRPGFNSSLDRYKHDEFGSIQFRTHRNSGNRLHPRPDVFPMFPFLQLTVTVGPIVEREQEGDAQNGSRRMRFFAAGARKFAAITHGTGLFPPPPSSPASGGAGGSGELASSPPLIHDYDHRHHFHTFPPHHAQFLLPASATFLGSSPQSSPSSQHDRAPLDQLSQQPAAQSAIQRERTLKSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1J5</accession>
    <name>A0A914H1J5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g12379.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12379.t2"/>
        <property type="gene ID" value="Gr19_v10_g12379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000594">
        <property type="entry name" value="Transcription factor HIVEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF2">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1265"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1293"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1724"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1859"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="2249"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="2440"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="740"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="800"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="940"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1323"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1450"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1546"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1633"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1665"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1924"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2108"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2309"/>
            <end position="2394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="384"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="747"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="812"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1152"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1383"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1450"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1546"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1928"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="2112"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2159"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2186"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="2317"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2334"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2350"/>
            <end position="2365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12379.t2"/>
        </source>
    </evidence>
    <sequence length="2479" mass="267213" checksum="509D1E761B7A3B74" modified="2023-02-22" version="1">MMPAGAASRKKRWHKAIARCPPPSPEVIPQATSNRPRQRHPLLGAPEQHTSETSTPNGLLGLEQLQQHDLRPLQLQQQFAALMQSQQQQQPTPAPHVQTAPLPPPHLGHQQQPPTQMSAAFLPQQLLEATAQGSNVNASGASVGAVPSASAQLSAATLGFYQQLLALQQAQQQQHGGGGASGGGSAAATPVVATLPQQFNTALHLQNSPGTAVLPQQLASAPSGAPQGGLSVLLGGLLGSNASLLHSLLAGGAGTAAPQTPGATAGGGGNALLTALAAQLLLPQQQQIAQPPANQLTASLLQMLNPATATLYAYQNYLQQQTPAPTPATAGQLQFLAQLLSGGVSAGASGNGGVAIGGGLQTALAALSGGQQQNLLSALAVQQVAQQQQQAAQQQQHAAQQQQQQQQHAAQQQQQQAAQQQQHVAQQQQQQAAQQQQQAAQQQQQAVQQQQPSQQEETRILLEQLIRQQQGRDQQQQIERREREQLQKQQQQMLQQQLGRFNAAVASGSGGCPEAQAPQLEQSPTMTATAVAAFGSAQEQLQQQQQQQQQHHTSVVVEQQLQQQLEQIQQQLNCNIPVEQQSAGSVQQQRQSTPTERLLTSEAVQDRISRLISENEAIVEPNPVLLKRRPYQRQGTSNSMTSQTSETAGPSQRCSPGVRSPGLVCVTPKLHPATTRSFSLHEVGFLRFGGGSLTSGQPINRHVSANPSGGGASTIASLTCNFCHLKFPNEAGLDAHEPRCSKKDVMQQQQTLQKQQSQPQFKLSSQQQHFQQQQQQQHLEHQSTIAALVGGGKGVARDLIINGGGEGGRASVPSSDNGTVVRTQQPPRQLHLLGQSNSDSRLKKRGLAADDACFEGVGGSGSSSELLVDVVRNGVPEPGLAESSKMARIECSTSTTSINLHRQQSIPSGLFEQHVQLSQQRSGSQETQHHLHQDVLGTSAAQQHPQQLQQQRALEHHQQQQQQQQQQQQQQQQQQPVLTMRDAIIFAITYSTDLRSSVKMPYFLTLTPADLEPCADLAAGGAATVHLRGRTRNITSETFVCLNKVRPTASEQRDNCSAYSVGWPPPSTDFAEERLLAQLFLSARTARMRQDSLQGDYTLAASPASTQLRTTHSSFWAQQQLKAHHLQHGHQRSAVEVEETAAIDTLKVEPPSETSGQQPQLQPNTSSKLLSHDKSIIAIQHQQPADGGEDVVKTEVGVDDKENSSSATNALKLNILLRKAPPPLLIKLEKKLGKNKFELNSLTIPRSSHNDEMEVYIRGRGRGRYVCERCGIRCKKPSMLKKHLRSHTNIRPFACSTCNFSFKTKGNLTKHLVSKAHRRKVMDADDNADSVRTSSVEDGERGMCDDMEDEEEDGVGRLVVAEEEEEEEEEKKRRRRERWDRVDDWDDDDDEEADDDEEDEDGSPNGEVPPPPPGTLTYRRFGQENVLVERETHTPPTLWMLMCPERSEWNGNGCSTGTNSGGDVQMESEEEMQPEGGDSAQNGWERAGEKKRSRPANLKLGGWPEPDDAMRERGCHSAPPAALCSPDHSRTRRRRNQLAKVLLLQEQKHRENNMESRAEAAEVQQNRQTSPPPLSNFIPQQPRQQQPPEPQPSLAAQLAVGLLASAPFHHGMGMPIGVAYPYGTVDVINTQQQQQLQQQQSSPKDLSQVHAGHQQQQLMFSPLEHHQQTSNSRTGAWNHDTAGGSKQRICRKRKFVTIVRHIPDSLLRAQSTLGAFLATDAQQLLCPLCGRKFRKESELSLHRQTHLIEQNAAARQKGSGGAFQCGDCPTIVRSKALLARHSENVHGTKSAALDEGVNAVPCRVPPLQQHLVPSMTSPVDPSGVLVSSSGIPFVSLMLPPSVSTAPGGPALAHSHHRNFLCTDCNLGFRSHGVLAKHLRSKNHVKTLEHSKVLGSIDAGDCEKALNSTKQLLTKMREQLGLDANNDGTAAATTSSSSSFDHRTTAEYPPPNYAMPCPTVVSPTPTRTTASGNSFHDQFAIGAIAEPPQRQDNGTAVASHAKLRISNSITAQKRIAAAESLPHGLKRKNDDATLVDELALFPNSTLRRDVFSSPLPSRAKISREEQISQAESPLHSLAQVAVEVAAAAAAAVALGGGPAAVPSRSSAVCASVVPPPSQSPAQPPAPPPKPGASSAVNVWVPPKLEQLAEPPTGDSRKSSTPDLHNGQSNTDRLGTLLSNRSAEETSESTGTRSESSTPVQRSNAQQPLLAFPPTVTATRCQLCELNFDSPAELAVHFHADHIVMRHGRDFRCSRRNCEKVFPSRDSLRAHIHAHFFGGGATPGHSAGGGDGREEQFQAVLCAASCPASPSMSVRQRHPPAPSAPPPSAQSPGVPEESHTTEQLHNHATMQSHSSPPSVASSCFASGNGAGGGVGMASTPKGTRGVTREQQASDAKVSSVGFPSLAVATLLNCQFCGAQLADVQALQTHWLQQHVAQLARPHICVDCDAGFTTAEALRAHRELQHADETARNAQRISAGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H235</accession>
    <name>A0A914H235_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H235"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12962.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12962.t1"/>
        <property type="gene ID" value="Gr19_v10_g12962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="169"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12962.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36508" checksum="BEE95590330FB0BB" modified="2023-02-22" version="1">MEKSAKDFVPNSFHYLDFAGAALPTPEFLQRMANSLADPRQFFLANPHSGHLLGRRTRDRLQFARAKVLAHFGINDSATFSVIFTANATNSLKLLAENFVGGESDFCGTKKEFSTDVKCLAEDSLSTLLMLRDSHTSVVGMRHADNFERIVVVQYEDLCQFLAELQSKRQPLTLEDKMHTFGKKKSLFVMTAMSNFCGRVYDMTLARTLKRVLGPHWFVCFDSAALAPHSPDIGLSLCDFAVISFYKMFGYPTGIGALIVRRSSVARCLQKKRYFGGGTVKFVSPTSNEVEFRSSVEERFEDGTCNFYAISALLHAFEEFDQNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3X9</accession>
    <name>A0A914H3X9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3X9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13031.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13031.t1"/>
        <property type="gene ID" value="Gr19_v10_g13031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13031.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37779" checksum="FBF1009B7BD60F97" modified="2023-02-22" version="1">MEECWIIILVSFFGTNSLDNAEPVQLEKLEELPLQTFDELFVEEWLDKHEAEDLKMPAPTNFGQNVHHQIDRQNTQIGQIEPNLTDHSGQIEPNSTDQNPPLTESDHSDNAKNGEEQKSSNENIAEDERKRKIVAKFHAMKDEFMQKGKYSNKEWVKIETLMRQWAKWKWRLQENEEGNSQAGNNPEPQKTNGQQARQEASHWKTTLQRLYGNQQVIAEELHAELFNLPNVEDSAESLQPFTENLERICLQLNALWSREPNTRPPSPRGSQRKPTAEEHQTESELRSGGSTPRSSEATEVQSKTEELRRTKHGHLREPLEKKKFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3Z7</accession>
    <name>A0A914H3Z7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3Z7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13048.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13048.t1"/>
        <property type="gene ID" value="Gr19_v10_g13048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13048.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20627" checksum="E4C26B3D34DD61A6" modified="2023-02-22" version="1">MSKNKKAELKRAGFKNSYQNEIDETVAKELGITNRTISNWKRGFGQTEPKKYSRSQQNKLMKHYYEIKGKNSKMRDEDIAKILKIGRRTLHSVEEKLGQTTLKHKHSHSEQKELMNRYYEIKDKTPKLRDEEIAKMLKIGSATLIRWKRQFKRQKFYPNVVDELFVEDRGIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5N8</accession>
    <name>A0A914H5N8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted peptide</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H5N8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14230.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14230.t1"/>
        <property type="gene ID" value="Gr19_v10_g14230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14230.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15132" checksum="D93515BCB1E102CA" modified="2023-02-22" version="1">MTLKISSNSLTLVVVLLLVLVLVVVVGGSEWGGGWLSACVCVFIDLLLFDNDIDDDDERTTTLGWLWAGWWVSICRGATLPHPPPSPASSSFPFLLCPFIVIITTLCVQQQQQQQQQNEQFFVLDWKPVESMSTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H617</accession>
    <name>A0A914H617_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(S)-3-amino-2-methylpropionate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.19</ecNumber>
            <ecNumber evidence="3">2.6.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-AIBAT</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="4"/>
    <dbReference type="EC" id="2.6.1.22" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914H617"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13553.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13553.t1"/>
        <property type="gene ID" value="Gr19_v10_g13553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047298">
        <property type="term" value="F:(S)-3-amino-2-methylpropionate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000073">
        <property type="entry name" value="Probable 4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13553.t1"/>
        </source>
    </evidence>
    <sequence length="501" mass="55546" checksum="A85639598FC10E61" modified="2023-02-22" version="1">MMISTLVSRQQRLPLIAEASYRLVCPTNRRLTHSLASLASREPEGPAVRTPIPGPKSNILKDQMEKVHQTTSINFFVDYERSFGNFMVDADGNTLLDLFTQISSLPLGYNHPELIQLANDVRLIIPAVSRPALGAFPRTDFADLIANSLLRVAPRGLSHVQTMLCGTSANENAIKTAFIHYQTRLRGGAVPTAQQLSSCMRNEAPGTPSLAVLGFNGSFHGRSLCMLSITRSKAIHKVDFPAFDWPVANFPRYLYPLDENKQYNLEQDERCLAEVSQLIDTSKSEGRDVAALIVEPIQCEGGDHHGSARFFRGLQNICQDNGVYFIVDEVQTGGGICGTFWAHEQWDLPTPPDFVTFSKKTLIGGYFYRDELRVNEPYRIYNTWMGEPTKLVLLERVVDVIKREHLVAKAGELGAKLLAGLKELESRHPNLVMNSRGLGTLCSFDMPNTAVRDGFLKKAMSMGLLIGGCGEATVRFRPALVFTKRHLDIALALLDDALKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8E5</accession>
    <name>A0A914H8E5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H8E5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15164.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15164.t2"/>
        <property type="gene ID" value="Gr19_v10_g15164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002544">
        <property type="entry name" value="FMRFamid-related_peptide-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051041">
        <property type="entry name" value="FMRFamide-related_np"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986:SF24">
        <property type="entry name" value="FMRFAMIDE-LIKE NEUROPEPTIDES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986">
        <property type="entry name" value="FMRFAMIDE-RELATED PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01581">
        <property type="entry name" value="FARP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15164.t2"/>
        </source>
    </evidence>
    <sequence length="199" mass="22001" checksum="7450EB07A5982296" modified="2023-02-22" version="1">MCRRGMAQHFGGPIHCRPSEKVATTMTTTTTMNMMYTGGIRQRHNRSVGLRPLILLLNSAIVWCSLAQPHAVEAASSGHLAPMVPNSPLSIQSDPNFLRFGRSGSLNEFGIPHLIPTRTSSNFLRFGKSSASMSTSEPNFLRFGRQKGGVDPTFLRFGRANNNFLRFGRAAGGELLVAAEEEPFERDYRQANPNFLRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9H2</accession>
    <name>A0A914H9H2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caspase family p20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H9H2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15447.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15447.t1"/>
        <property type="gene ID" value="Gr19_v10_g15447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="5">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15447.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18929" checksum="F91ACD634BF2BAA9" modified="2023-02-22" version="1">MHSFLILRSRSTSAYELETAVHTGRLVQRITTALRSAFQSLPDLNQRKIYINSSTPRGYALIINNYQFEDGEVRHGFEVDVQNMTFLLDQLGYIAHENTNKTAQAPSIDKRRLSGCPSMLAELLGDGGSRTRRVTNFYRMEPLESFFPMMALKKGKSIFDNFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAF0</accession>
    <name>A0A914HAF0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAF0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14754.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14754.t1"/>
        <property type="gene ID" value="Gr19_v10_g14754"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g14757.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14757.t1"/>
        <property type="gene ID" value="Gr19_v10_g14757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275847" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14754.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14757.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10848" checksum="3F3C5472E9CC0199" modified="2023-02-22" version="1">MASQSFVLVQLFCLVMLARHSEPWGLLSDELSWDCKETNCHGIAKRRIVLGLQRDELSWDCKETNCHGIAKRRIVMGLQRDELSWDCKETNCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAK0</accession>
    <name>A0A914HAK0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAK0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15742.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15742.t1"/>
        <property type="gene ID" value="Gr19_v10_g15742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15742.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8392" checksum="2C04FEDBA9720B69" modified="2023-02-22" version="1">MRRTVHEGASAAQAEKEAGKSGGQKPAIFESVQKKAAGDTKNDAERAEGGNGAVGSDDKLEDPATDDYGFGIDVELPAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBQ3</accession>
    <name>A0A914HBQ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBQ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15636.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15636.t1"/>
        <property type="gene ID" value="Gr19_v10_g15636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="317"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="785"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15636.t1"/>
        </source>
    </evidence>
    <sequence length="821" mass="91537" checksum="5EE733331778F2EA" modified="2023-02-22" version="1">MNAPTSPHRHNNVANDGTSAEGTKTDQQQLQHGRSIADPTTTTAVAPNALCVQSEFDLRSVHVAAQCKALAASPAATALAHSDPNLRQQQEDVPSHAFALHSPVIDDDNDDIAAAVRCCDAATREECSNHLRGGDDGGALDAEHPAAGDETRGAAADGDGDTPDGAMQRGESSAPRSATSSRKSSVRGRLRNQSELERARKGKKLLTDIDFEGILRIIGGCSTWQILIYLIISAHQMPHAMFNLSVVYFTYLPDHWCKVPSFSREYIENANNDIGPGWSWEKALDSGIAFPQVRYSQRRNTKHDQEKHLRICAVYTITEAQLKAYLKMNFTEAVLLARERPPYLVQRCKQWEYDRSIMKDSVVTQWDRVCDDNWSRAHVHLSYSLGYLVGCLMGGFISDRYGRKPAIYGFSILSTIFGFLLSFSREFEVFLVVRFLLAACNEAADLAAYVYCMEITGMQYRSVVGSLLQAPWACGYAFLALVAYIWRSWTSIQLITTAFHLLALLLIHHLPESPRWLIATNRVDEAEKIIRKACHFNKSSLPSDLELVRHAEQRKWLKYNQRPHFLHSFKSPTMAFRNVIIFLVWIATALVYYGIVIALSDQSTPGRAMFVGNFFLNNAIAGAIELPTLMTCVFLLHSGRKRSQVITLISAGTLIFVAMCLSLREEMTFSLLFMLAGKVCIQGAFNILYIFTSELYPTVIRNSAVGTCSMMARVGSAASGYIAILSDVTLPTVPMAIFCIFSLFAGVLIYFLPETKDLPLPETMWDAVRMLNNTEAHRCVGGIQMDEGDRDESYGPADQQHQRDDEEEEEDVPVYTNASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC40</accession>
    <name>A0A914HC40_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HC40"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15981.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15981.t1"/>
        <property type="gene ID" value="Gr19_v10_g15981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15981.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41054" checksum="CB01FDEE7B776DB7" modified="2023-02-22" version="1">MDTNFENAQEEQQLNRRILCLQRKCKQLEEINAQYCDEDDERLKQIDATEEEIRALKKDNAFKAKQIQQEREENLQLKLELEEQQKKAEEMVLRNAIRIGSKASRMKPPSSASTSSSSSRSSSSAAGFTSLMHSVGVAANKNTVILYSPSFSQRLDDEDANVVEGRDSGNFSDQDQQDSVGNAGSGKLLSNVPEVGNFGGMSLVEELELAEQQQKMKEEIDKAQLEQHQQQNIVEEPGMAVQHQQQNNNNNSHTPNGAPLRHFLLSLVILLFFFVLIVLVVPSVQRGQLVIRISVFFPSAIKLAENVLQSKDVGMEQQHLQQQFVAALSERVEQLELELKETHTKFEQQLEELETIRMMRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HC58</accession>
    <name>A0A914HC58_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HC58"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1575.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1575.t1"/>
        <property type="gene ID" value="Gr19_v10_g1575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1575.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31994" checksum="1953C582FC1621ED" modified="2023-02-22" version="1">MANRTARDAHTVKGTNPQYLIEKIIRTRIYDSLYWKEQCFGLSAETVVDRAIELRYIGGIYAGNIKPAQFLCLTLKLLQLQPDKDIIIEFIRQDDFKYVRALGAMYIRLIFNSVEVYKYLEPLYNDYRKLRYMNRMGKFELLHMDEFIDNLLREDHYCDVQLPRLQKRQALEEKDQLELYASALDEDLERLSSDSEDDQEVQRSRPSIVSRRRSRSRSRGRSRSKSRERRRRSPSADDRRSGRSAGKDLEREIEESNALRKKLGMAPLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCG2</accession>
    <name>A0A914HCG2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCG2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15773.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15773.t1"/>
        <property type="gene ID" value="Gr19_v10_g15773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15773.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16640" checksum="78E5EF9985730862" modified="2023-02-22" version="1">MAAVAQMSSHQQQQQQHKKLKTFQAYLPPGARTYSCAHCRANLANHNELISKSFQGSQGKAYLFNSVVNIVCGPAEERVLLTGLHAVADIQCECCKTTLGWKYEHAYESSQKYKEGKYIIELIHMVKDNGWASQPVEKIRRRNNSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCG7</accession>
    <name>A0A914HCG7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCG7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15777.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15777.t2"/>
        <property type="gene ID" value="Gr19_v10_g15777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34593">
        <property type="entry name" value="MATING RESPONSE PROTEIN POI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34593:SF9">
        <property type="entry name" value="MATING RESPONSE PROTEIN POI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15777.t2"/>
        </source>
    </evidence>
    <sequence length="542" mass="51426" checksum="D85139BF01D77AE9" modified="2023-02-22" version="1">MPGVVPEGVSSGVLIGVVPEGVSSGVLIGVVPEGVPSGVSIDVVPEGVSSKCFSAGVVPEDVSSGCVSIGVVPEGVSSGVSISVLPEGVSSGVSISVVPEGVPSGVSIDVVPEGVSSKCFSAGVVPEDVSSGCVSIGVVPEGVSSGVSIGVVPDVSSKCFSVGVVPEGVSSKCFSVGVVPEGVSSGVLIGVVPDVSSKCFSVGVVPEGVSSKCFSVGVVPEGVSSGVLIGVVPEGVSSGVSIDVVPEGVSSKCFSAGVVPEGVSSKCFSAGVVPEGVSSGVSIGVVPDVSSKCFSVGVVPEGVSSKCFSVGVVPEGVSSGVLIGVVPEGVSSGVLIGVVPDVSSKCFSVGVVPEGVSSKCFSVGVVPEGVSSGVLIGVVAEGVPSGVSIGVVPDVSSKCFSVGVVPEGVSSKCFSVGVVPEGVSSGVSIGVVPEGVSSGVLIGVVPGGVSSGVSIGVVPEGVSSGVLIGVVPEGVSSGVLIGVVPEGVSSGVLIGVVPEGVSSGVSIGVVPEGVPSGLALCRRASLPASQLALCRRASLPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCJ4</accession>
    <name>A0A914HCJ4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HCJ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16260.t4">
        <property type="protein sequence ID" value="Gr19_v10_g16260.t4"/>
        <property type="gene ID" value="Gr19_v10_g16260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16260.t4"/>
        </source>
    </evidence>
    <sequence length="118" mass="13405" checksum="1FFB9CDF59534A61" modified="2023-02-22" version="1">MPVYAEQSYNSKLALRFGFATAVHKVTLDEEVLYSAIQKILSNYSNFKDNAKRAHAFFLDRALDGMQMAEYGVRRALREGGRGRRWRMTKGMDLDWLSYVHLDVAASLLALALFLANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCK5</accession>
    <name>A0A914HCK5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCK5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15804.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15804.t1"/>
        <property type="gene ID" value="Gr19_v10_g15804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15804.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18875" checksum="DF67F96C3E94D168" modified="2023-02-22" version="1">MILRKVKAIGLVGKTERRSNWIGWEDGKEEQLDWLGRRKGGAIGLVGKTERRSNWIGWEDGKEEQLDWLGRRKGGAIGLVGKTERRSNWIGWEDGKEEQLDWLGRRKEEQLDWLGRRKGGAIGLVGKTERRSNWEMYKMRRKKSESHNTVVVVRWEKAMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDI7</accession>
    <name>A0A914HDI7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDI7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16028.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16028.t1"/>
        <property type="gene ID" value="Gr19_v10_g16028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16028.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25199" checksum="C1B9432B48AC2C5B" modified="2023-02-22" version="1">MLFIADEFVPRANDEDEFVPEADDEFAELLELVGTEEFVDAVPLVAGGFVVVVVGLAVVTVGVDEFVPEADDEDEFVPEADNEDEFVPEADDEDEFVPEADDEDEFVPEADDEDEFVPEADDEFVELLEFVVDEFVPEADDEFGELLEIVGTEEFVDTVPLVDGFVAVVVGLAVVTVGVDEFVPEADDEFIELLKLVVDELVPEADDEFAELLELVVLLLSLLDSLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDN8</accession>
    <name>A0A914HDN8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proline dehydrogenase</fullName>
            <ecNumber evidence="6">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914HDN8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16549.t3">
        <property type="protein sequence ID" value="Gr19_v10_g16549.t3"/>
        <property type="gene ID" value="Gr19_v10_g16549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16549.t3"/>
        </source>
    </evidence>
    <sequence length="673" mass="76438" checksum="2DA829C62C31FB65" modified="2023-02-22" version="1">MFEQKKRAPIRSRPTRSLFQSNHLSDLSLGDILSNSLASAFESFYSCTLSNGIKMLALQQANSDTCRLFLIGQVYHRMANLLCRWSYSLRSPSIAPQYTSHYHQRRQQQQSFASVSKQSLSSSSAGEASQPPPSALLKKSPEQLRAESELCYQRLDLTFQNAKEAFKSKTNFELLRAQLVFACCQVNWMVQHNQKMMRVARVLLGKRLFNALMRSTFYGHFVAGENIDEVSETVAELQRFGVKSILDYSVEADISEEEAKEKAVEGIDEDKTEQIPPALDVLASSVLPHHEAQLEDTLGDQSVADLVDQTQKQFSVHKEFGDRREHVVSARTYFYSGESECDRNAEIFCNCIDATAHATMGQGFTAIKLTALGRPRLLMRLTQAIAQMENLFRVLTGSSWENLCLSRICEDELIDRLQEFGIKSDQKAIREWFKHADFNEDGFVDFFDWGRLLDVEAGKLQKVFQVLNINTGKLEPVLNNLTERESLELSNMMGRLTKIADHAVSRGVRLMVDAEQTYFQLAISRLTVALMRRYNHERGFVLNTYQAYLNNTLASLTIDMQLARQENFHFGCKLVRGAYMDQERLRAAAIGYEDPIQPSHQATSDNYHQCLDAIVGEWAQRGRNTVSVMAATHNVDSVRYAVELMRQRGIAPSERVICFGQLYGMCDWVGFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HE83</accession>
    <name>A0A914HE83_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CXXC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HE83"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15807.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15807.t2"/>
        <property type="gene ID" value="Gr19_v10_g15807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="6">
        <location>
            <begin position="266"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15807.t2"/>
        </source>
    </evidence>
    <sequence length="621" mass="65211" checksum="5A23A46094E8E3DE" modified="2023-02-22" version="1">MDMSSGNSSDTSVALCSSSSSSCSEQRQLRTSKEETACALGPDVPDRRKHSGEYESEVSSSGGCSAHRASSTPSSGASLFQQHFLQTNGNVSGSPVMVQHGGFSPGSFSAQTDQMSINSAATPMQAFAAAANNIGLFCAPPGASVPQFPSSVPSGAFSLVNYGHRPPMVQQLAAVQQQRQMNSSGNPNGSSATIHSSASTSSTSSSSINRSQRCGVCRGCQCKPCGQCTYCQDSPQFGGPGVKKQSCIERRCLRVLENRLQRDAPTFKARVGCNACEDCRSPDCQICLVCLDKRFFNGRYMQTTHPCVAQCGALCAKKRCNNATSLELPCSPLDRPSLKRPSSDSSANQTQQQPLHYHHLPQHQQQQMAKRQLIQPSVSNSASINSNIARILNAAQHGGGEGKAEKYGGAGGRAFGRSSGGNSTTNSPMSENGAVSSADTSPSQQQQMLMGARPLWPSAQQCVTVAAHQSPAPVLVPLGVPYAAAAASFDQQMAASLAAAAAVGFPSAVQQNQHNFHSSAVYNNNNNYPHKFLGYPKYEYFEESAVAAIGGGIMAEGMPTEHQLHQNHQQSPGVRPSGGGNVPGSVGGGSGADNANNNNNNTNPFVPPSYSAERKVVLQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF43</accession>
    <name>A0A914HF43_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HF43"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1604.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1604.t1"/>
        <property type="gene ID" value="Gr19_v10_g1604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="8">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="7">
        <location>
            <begin position="86"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1604.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28552" checksum="D87F59442A6EF9BD" modified="2023-02-22" version="1">MTEAKKLPEVPETLLKRRKIRAAQKAAKAKNKLSSIKKARTKKVEIFKRAEQYLVEYRQKQRQLLALKRESKKVGNYYVPEEPKLAFVVRIKGINKIHPRPRKVLQLLRLRQINNGVFVKLNKATIQMLRIADPYIAWGYPSQKIIRQLVYKRGYAKEKGQRIPITDNNIVERSLGKHDVICVEDMIHQIWTVGPHFKQVTNFLWPFKLSNPVGGFKKKSNHFVEGGDYGNREDQINKLLERMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFC1</accession>
    <name>A0A914HFC1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFC1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16458.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16458.t1"/>
        <property type="gene ID" value="Gr19_v10_g16458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16458.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="19202" checksum="76689E8C5A9268A1" modified="2023-02-22" version="1">MPKVFAPVSGSISAGNIQPPTSSSSTLATAAAVGTNSTSAVVPSTSMQHADVGGIPPALICKQNLNIKTEPVVAGQQQNGGGCGKRFKTLSKVQCAECDEFLPNSDASRLHHTNVKHLKLCLYMCPVCNKEFMSAFNGPRISIQHIKTPKRGRMCGYGSGGYGSGGFGSGGYGSGGYGSGGGGDCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFI3</accession>
    <name>A0A914HFI3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFI3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1705.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1705.t1"/>
        <property type="gene ID" value="Gr19_v10_g1705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1705.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24797" checksum="57D9404DBE6B273F" modified="2023-02-22" version="1">MNFLCFLGKKRPQEQSPPYRNIQQQVEEVSAIQANVVVVESVDVQRLVKAQQTTIVELEKNQQNLQKLIAALRERVGRFEAAKFVERERIGQLELELKETNKKLEKLGNNSKDAMEKPRRGVTKLKTDMAQLVEEQNRKFEQQLDELGNNAKNALDKALEAKTVIELKEYQTLMNAYDALQEKVGRMKAYQKEQQQNIYMLTRGQKNHKIYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFS7</accession>
    <name>A0A914HFS7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g17113.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17113.t2"/>
        <property type="gene ID" value="Gr19_v10_g17113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045852">
        <property type="entry name" value="UNC80_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19424">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2173"/>
            <end position="2195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2201"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2273"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2337"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2372"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2439"/>
            <end position="2464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2476"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2506"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2546"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2576"/>
            <end position="2598"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 central region" evidence="4">
        <location>
            <begin position="224"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="5">
        <location>
            <begin position="766"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="2707"/>
            <end position="2927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1923"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1970"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1994"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2040"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2090"/>
            <end position="2104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17113.t2"/>
        </source>
    </evidence>
    <sequence length="2940" mass="329974" checksum="0D8A1B2FB2220642" modified="2023-02-22" version="1">MLPFGFVGEMLQVPYTANSSPLPAPSGGSSLSSTLRRFASRTRLFSRVDHRYHRAYVSMTQAEDDEEEPTAQPFEGSADGDRKPLVPKGVSSTAPLRKSTRSAPSTASRSTRRTSVRRLAQGRQRLLKRNSPSGGVLQTPPPTATLQQQQQPSIDAIGSTKKRESLRLRKVSKTQPPPPMSTSMPMEQEWAEQQQQVNRDQHTENVPPVVRRFTTDETAGNARPDSTVPSGVRVVSFVQRRRRTASFKSRVSRPPNWRHSMRVGRTATLADDEATADLLKDTRRAPQRQQQQQQSKVSMSLQCQQHSPPEAPRSPVFMLSIARKANIGGGGRLQVTQHSQQQQHSPERFSSSTTATSAVAIQQQRQQQQQLADAAEEEDEEEMYKNMPWLCTLLQFVQKMDFDCSHEQFCTKWCFERIYRQCQRLFEALMVVYGQTTADGRLDRRQQFIERWQNSQQREAKKRHSSNPPRRESANVRQSGVDRMPLALRGLIIEKLSEIEENRAKKAEETDQSVNPSELRLRRPPQIVNFVRVQMLGLVHAPLSALLKGVVVLKADQLIPSVRIAWTLLIASDDANLVATAAALFICCAVKCPQECTNLMAAELASADPSVRTSAVLRFFVLWRQRYHVWLKMEDGSQLIFKIPPPSIDFTLPSPSIGLSQLPVVDPPWMPPVKTKVEELSLKEEEQSTSQTIMTMTRTRRKQKQEMVRKAIRRADERQRELREQFPLRATAVVQQVAYEPALFQHQLTSADSSQVDDPVLLDSVHQARQVVPVAQPLFPSSILSVVPTIVELLDDPQVDGSGISVGETCRRVIWSCLVEDTALFLRHFFEKLTNRPKQEYLLALLRRLVLSFRPLPSQTAHTLLNALFGLAMFYVRTPGEGSDRSLALALSMCWLVVPFVHGLYFKDLKQTLKKEQCDQAIMVTANVPSAKKVIVHGPDSQQGGIPTQFPVLEDTQFQHLLADSIEFYNISAEEADQHFLYDPKTFMLHNPNAYVRDFYFFHRSFYPQLQLVRLDAPQAQQRIREHAVQQKLIETGKVLLTHNALRHSHEAVIPQRIFFLHDEFTHLPSFPRRAVETCFGMYQGTSGEELQTMDALHKFAWSKLIANMFEKMENAFMFGDLHLFINVINGIMIIHCEDVLILRRCMAAYLGMSIHFNSLFASQGFSLIMPTILRCYSQRQPNRLFTQVVEFVCKQFYVLHPNPMRVKAKYLFALLLAMEQMNEPVDQLDILAMLPHPKPLQALDLCYRDEPSTFNFLTDAMASCVTICAFAPETRRAHQMLLCMQSLLPHLIRHMEEETSQRQQQAAALAALKLELSAFATLSVELRALVNSCEALARGPTRSFDLAASAGGSAGAAEAGTVLLAPAASNQSHAAEQQRRGRSLGGGGTDSPQFFDPPTIVEDEVSRPQQSTASAKTEKKVTVSGWADGTTAAAADNEALKEQFRGPRDALLTLCSMFVRLGSDRLKELGRLSAGLDHSRGGMPELFDHKCHVKLSEVAVALLKLAPYDGKTLSCGGLRHYFTDVMPVIDWSVETNRSAVNIILRRLDKTIAKIAKRPSTRRRANWGAISFWLVGLQQTLLNSPYIAHLHSLKTITLLCLRLTLGDPFGTLDDQTVQAFTLSTQQNSAGPGSAYLSSVQAPQTVLSPHTPPESFCSVVLRLTSFLMTTLGQLVFSLELICSADNIGPLADRPEAILCQFLIPLFLRAAISGKEAPQFRTKDLNFCLNLIQNAISTPSLAKQSVAPAMSGSSLATSLMRDSAGGRQGSVSVTDRGGYSATVSTARIMRDSVVQTVMLALKVIVIAFHKQLTITQWMRIARIVRELVAKKGGGAALSPFLKFMLGANLPIAELLQSIVQNRLNQRTVNDVDTAWVGELRERIARIRSDPVRKAHFAQLRSLHRELHLLREDFVMRNLEIPRSHTPTIGGELHSDSGSSQGVGTGAVAVRGESTARRLSSSALGKLRWIQSKAGDSERSQGPKVSLTGTLHDSTIVEDAEDENASGDGGEGAADVGRRERRSLGMFRSVRRLRKPRLASLEGGSSSRDSAMPSTGGMELGEVGGSAAYSHRSSSLKRGGRHDERQPGKGAENSPTGAMSTPSQISINKLDGERPRVVSFSTPRHSSVSQTISEADSDGTVEFCITSTKHLECRNWKKSIDIITQMSLFCSTTAPIYGPCVLGLQLIGVYAIILFHIWPSEFCNGFMGVDILFVVFGFLMSIKLVELYNDAGNNNTVTLVPASTSSANNSLSYYDKFLPRFVYEIRRFYYIEFTQIIPLNLTLILGSLVGGFVFFLDDEMEQLRKDSLWALCFGTNHQLTDVDWTFDLIGISQPRPLLHLWAICVKIQFVLALSPPVLLLVRLKSGTKSASFKCQIVQLSALFLLLILPSFLFWLSSTSKSVMMGWACSRAWQFLLGTMSALIANQNRRPKCQINEQSKKCLLFSIIVEHLLFYLAAVCLGVVFFLPSVFWPPFFQYKTILTISISALTAFLLYFFINRLKQKIPLSALSQWLFVNFGQFPLFCFLFHQPLAVFLRSFLTVSQLNIFEGFLAILLITLSSLLVQQIFHKLFANIRQQKCFSSLCVYLIIFGYAFCALFAIAPGTIRLNQKRKNETPIPIFDEAQHKVQFWPLDVDSVRKFLEQLQTEAYQNELSPLLNSFAKVKINEMLKNSFTFDTDIPGTSADLFVHENEMAEDNRHVKRIYEWMLKGNGTRRVLLFGNSHAQVAWREVETSLEGNFSWLHVVSVPGCMPLFENDWRTIYGIRCSQTVKGLLKVAEKTLPDFLFLIFRWYDDLQPQGEPTNLELDPNLNEMQSFMDKLQRFVSGRIFISAPNLQFDTEISHQLAKRIWQNNSLEGLNKNYSKHLEENNSSYQRLGRLRCAKCSVFDLAKEFCWDGICHAFEPGSQLAYFSDRNHLSFLGRLKARETFAKIARSIEEGGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFV8</accession>
    <name>A0A914HFV8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH CENPB-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFV8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16246.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16246.t1"/>
        <property type="gene ID" value="Gr19_v10_g16246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057560">
        <property type="entry name" value="Znf_SCAND3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23663">
        <property type="entry name" value="Znf_SCAND3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="147"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16246.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25667" checksum="F0D582990C7CFE0C" modified="2023-02-22" version="1">MDSICCVCKLNYQGSHHCSSCKMPCHAICGDAGDEEGYGAQVVCFNCKNKGPEIDTNTQSEATGDGENKENEPQLHDDDDGIPVDRKRNRNNDAAKKLEAIEWARRNSIKSAAKKFRVDRKLVRRWMEQEDKLKQQMNTCGGKRKRLDGAGRPVQHQDIDTTLADWIKEMRLNKKPVTRSIIKNKAAALFVDTDIKVSEGWLEKFLKRHNFVLRRRTTAGQKPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGI1</accession>
    <name>A0A914HGI1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGI1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16407.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16407.t1"/>
        <property type="gene ID" value="Gr19_v10_g16407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057657">
        <property type="entry name" value="MAT1_CAK-anch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25811">
        <property type="entry name" value="CAK-anch_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16407.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33615" checksum="09A0121E47D0AF92" modified="2023-02-22" version="1">MTTANHRICPKCKTSEFQNRSLVMMLNECCHPLCQNCVENLFARNVAPCPYEGCGKMLKRSGFWTQQEDDFATLREFNDYLERVEEIVFRLVNELKVEETEQEMHTFKEEFAEAIERNRRRPTKDDLWVKAMLDEEMARRSKVQEDNSERRDRSGSVKFNPKAIIEELRSSDLPAEVVLDRQRKKRIEQEMADKEEMIRRKRDKQEEKLRAKERATFGVIRPSGKPYYHSQPTLFLNGPPVPGDEELERSGCLQFVRQAPPSSVAGGYLARIGCTRAILEAHADLLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HH47</accession>
    <name>A0A914HH47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HH47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1731.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1731.t2"/>
        <property type="gene ID" value="Gr19_v10_g1731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1731.t2"/>
        </source>
    </evidence>
    <sequence length="236" mass="25903" checksum="5D889F60CB1C1ABB" modified="2023-02-22" version="1">MTTSFTTVSMMASTLSETSLLTPPNLSCCCVCKECNGTETIKRSVRSAVSDSSSDESSSSSEEKADGCEGKNSDDCTTRPPKKKKTKSKHWGSTTPSPTPPPPKNRVCHDNHECCMHWAAKGGCKSAPRTMNTWCPGTCRFNGCRPHAKQGTPGCKNLYSECKRWAHYHENDDDDHNTLLHGGGSKPSSMNECERNPHWMAQNCAKACKKCGRLTTPEQCAQKMPTDYVPTMINDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHK1</accession>
    <name>A0A914HHK1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HHK1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17420.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17420.t1"/>
        <property type="gene ID" value="Gr19_v10_g17420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17420.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30872" checksum="02A0A6EC421C432B" modified="2023-02-22" version="1">MASYGQQQPPYQPQGNNPYQSQPGWNVPNQAQGMPDYSSNPNNAEGGGMPKNELGFNDQTIRAAFVRKVFFLVAVMLGVVTVMCALPYMHPPLMAFTKNNFGLYLGSLITFLVVYFALMCCDGVRRSFPTNLICTGILTLSIGFVTMVITAYYSVESVVMAAAITTVSCAGIALFALVTKRDITSMLGFVLIATMVLMLFGFMVIMSSFFFHSRILHIVYASLGALLFMFYLAIDIQMIMGGRKYEISPEEHIFAAIILFMDIIQIFWFILSIFGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHR5</accession>
    <name>A0A914HHR5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHR5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17278.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17278.t1"/>
        <property type="gene ID" value="Gr19_v10_g17278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17278.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44195" checksum="D19D3107350418AD" modified="2023-02-22" version="1">MSTFSTYQPQLSMFGDVPMFATANSSIVGTSNATASTTASESTSVLQLHGRQQPSAALLQQQLRMRKEIYRYTCDELLFAAAWSNKLYPDKRFRLVVGTLLDEEGTRSNKVYIIELDESAGELVRKASIVHGYPCSATQFIPNTDVSQPELFATTSTCLRIFRYHPAIASISQECELSSTLKTKSSAYSSPLTNLDWNEVDSTLVATCSIDTTCTVWNIETSQPVGQAPTVKGMQKTQLIAHEKPVHDIAFTRLDNGRDQFATAGADGSIRLFDSERRMLNHLAWNKRDPTKLATVAHDSNEVVILDVRIPCRPMARFGNHRGAINGITWAPHSTVHLCTAGSDRQALIWQMNHFNREEPILAYTAESEICQIHWSSNFHQWISICFGNSLEILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIL4</accession>
    <name>A0A914HIL4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIL4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17507.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17507.t1"/>
        <property type="gene ID" value="Gr19_v10_g17507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037203175" evidence="2">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17507.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9898" checksum="CEE99F29D78DADBD" modified="2023-02-22" version="1">MNPPSLVCPSASLLTLFFSHPFFLQCVLNRTPPAAAAAGRSGWKEEEARKDGQRERRNEGGQLTGGRTERNFRKRKVWQRCGPPAHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIV7</accession>
    <name>A0A914HIV7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17791.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17791.t1"/>
        <property type="gene ID" value="Gr19_v10_g17791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17791.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19383" checksum="C31CE6E3488ED82C" modified="2023-02-22" version="1">MSGPNGQQCCERSTADASLYFDSFGKISGCECPQARGSPSLSAACSVLFLVVTSMELFPKKWEPSGATSEWLRAVPTQDDGTAQQFGEIAELGFGRYGLLGEGVLQWLGERTRCGCRGPASYRFTDGQGSEYVELSETAHSSALKFESKARRKADVRVPQKRDRRDQPIDLDTIDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ84</accession>
    <name>A0A914HJ84_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ84"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17676.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17676.t1"/>
        <property type="gene ID" value="Gr19_v10_g17676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038055655" evidence="2">
        <location>
            <begin position="29"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="3">
        <location>
            <begin position="563"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17676.t1"/>
        </source>
    </evidence>
    <sequence length="638" mass="66562" checksum="931A7C135D33D2C3" modified="2023-02-22" version="1">MTELLHPLLPRNVVTLCFLLIFQHFSSAFLFGGGGGGGTCSCPSAAPAPCCAASSCGGGGGGAIIINCNGGSDNTHFKEVEVDVGEVADVEADAEEVADVGEVEADVEADAEEVADVEADVGEEVADVGEEVADVGEEVADVGEEVADVEKVAEQYLLEVAQEEVVVDVVAEEETVQVAAAAALVAEVEAVQEAAEAALVAEAVQEAAEAALVAEAVQEAALVAEAVQEAEAVQEAEVVQEAEAVQEAALVAEAVQEAEAVQEAEAVQEAEAVQEAEAVQEAEAVQEAEAVQEAEAVQEAEAVQEAEAVQEAEAVQEAEAVQEAEAALVAETPSAAQVAIVLEEELETANMSRLLHNPPATRQAVTRSPQRVEPPVRATAVLREKAASMPTNKRPFNLETDQQQQQQPLPAPTPEPPASSQQVQPANPEPEAAEAALPAAAETETAEAAATSEAPAPSGGGGAAEYGGAESPAAAGDRLQEVQEEPNAADEQSPTTTAEEEERTTTSQPSQDQQEQKQQTTTGRPPLAPGSAKAKAAAAQVNNENTDAFVEPVDVSQLQLTNDTECNSEELRRIITNNMDNELNVAKRAIQVAAEARFGGRFDVVCSHHDFSYITNTELWCQETRETTSCYAYRQLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKD0</accession>
    <name>A0A914HKD0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HKD0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g228.t1">
        <property type="protein sequence ID" value="Gr19_v10_g228.t1"/>
        <property type="gene ID" value="Gr19_v10_g228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g228.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13179" checksum="9EFF39C8F7DD0671" modified="2023-02-22" version="1">MKLVRFLMKLSHESVTIELKNGTQVSGAIQGVDVAMNIHLRSVKMTVRGREQIGLDTLSIRGNNIRYIVLPDSIPLDTLLIDDEPRKKPTQRRFGGRGGRGGGPRGRGGRGRGGPPRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKL8</accession>
    <name>A0A914HKL8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKL8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2001.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2001.t1"/>
        <property type="gene ID" value="Gr19_v10_g2001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036975371" evidence="1">
        <location>
            <begin position="19"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2001.t1"/>
        </source>
    </evidence>
    <sequence length="769" mass="89588" checksum="745CE6EEC786CB4F" modified="2023-02-22" version="1">MLELIFIFFLNYLDNSVGAPPLYQWNLTNPGNNVPIFAQLIEDIYQQSLQFIDVFVPFKLELVKNDKVSFNFTFVKYASELAKFRVIDNNEEMRPTFKAHAGVLDFQDEFVGFRRYSNKLDNFIANEFNKNIFCPEKAIPKKVVDQIMQLIFSLAARILLSVTYDDYYSYDGIGEWQLQTLLSAYKILAAENGIFPFPILQIDVNGDHFWAEFIDQNISKNTSEQMQYIENFNFVLKLSEFSLSYYDVYKVLKEILIGIHFPTNPPPPVQAVHTFLKQYFIAKLDHKSMEQYNVNKVVCAFVHFGRELQRRLVEHTGRIRYPGFSEYVQRMEAECGKAPHIKHAYWSTYTKNTPSRRSKQLEMELFHEPLWNNARAIQIDSHECKAVLQFADALSKIVVNFELNSNKENEEYSIDGITKLNEFKLLLRIIDGIGDTENYEKLENFEKYYSKNDSLNKLSMLLKQIIKEYSCTSSNSCPLNGHLSLSNYRQKLPKFGQILFETFNEYSDNVKYDENKQLLSFPLALSEHILGRLNDFVQSLPTSITDIGDDVDFVKTIQNIASMDNIEIIQRKRIPKFANRNLFKLLFILAIRLSAQIEQNDLAEKYLKTFLFAFNQSLRTSNIPYGFFGFKIRKVNKMVEVNLPTWKLPYFIYLENTKELEQENAFENFKFIHSLSEYSPTIYEIIKMANILDLLAKAEAKNTSSFKKAMKELTSNFVLAKQQLCGGKPKKEEIREQFKDNCMLQYANVIEVVDIAPQKGQVEASVRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLR0</accession>
    <name>A0A914HLR0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HLR0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1945.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1945.t1"/>
        <property type="gene ID" value="Gr19_v10_g1945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1945.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17316" checksum="ECBB294970AC4275" modified="2023-02-22" version="1">MGTKWQQQQQQQQQQQQQQQQQQQQQQQHKSYVLITTDQQHLLTQKATGPLSAAKANNSNGIGEITDYYCRGLRLKNNWGLRRVRQHLCHQGLKRDLLEASMERKFELKAKELAGKIQASGRQIKQQPSTEHSMWQRTDCVYLWLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLS5</accession>
    <name>A0A914HLS5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g1956.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1956.t1"/>
        <property type="gene ID" value="Gr19_v10_g1956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="863"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1484"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1541"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1574"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1616"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1671"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1716"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1754"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1503"/>
            <end position="1771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1956.t1"/>
        </source>
    </evidence>
    <sequence length="1877" mass="216349" checksum="7C3C82CE1D6AEAE7" modified="2023-02-22" version="1">MSFPRDLDGSANKLLALYSLFEMVHQSGHFLFVYTVFSGHYLIEFPIAVRILSPSYFAFGCTTLLLFFTSIDRLLYVLFPLRTAQYENAIICCVVLPIAGLFGAFYVCSLYLNSGSLDDQLIIGTLTDLGTIAFIQSKNLVQLLYEIVTIILLATIVIYALIAILLHFKKEVADARVINPNPGNAYAKLKAKLGYSDKLLEQHIANEFNKNILGHEKPLPPAVVDQLLMLSISFAVRLFVSFKFHYYVFDKDRESFDKWQIETLLSAYKILSTKSGTNWICPFKIIQCHEHTAEHDQYIQNFKFVLKLSDFSLTSFEVYKLSEIILIEAERIMDDKSNNNVQAFEQQPLALYTFVKQYFVEIIGKKTTPVPKSMEKLVHCALLSFGRELLFRVSLTYKEFRNYFFAKRENECKDVYSTEILDSFMLAFFNEPLRNYPSVIQINVDQCKGVRQFAETLPFKKYSDKVKYDENVQLMSLPPKLAEHFLERLFTLTESKSASICEIGTELDFVQTMQNVASTEQFEKVTAGRSPRKLPCYAYAQQHANNILRNVEDLLEEMASGNKIPKFESIEIAIGHFILVKEELCKEKSIEKNLRKYFGENLVNFGKAINIDFSPHNELHQIGREIIKKIEQMLQNGDDWNYAYLNNSKMDEWNLLEYDLRKSGNNQKWEEIEQLRDEWKNSYNKWVYNKFAEERPSWILVVFASIYTFVATVGIVMNFLVFFVTIRTKFDPIKPASPSSDARESRSQLENWALVLSLGDKTGSRVRASVLIQIVPFPRDLDGSANKLLALYSLFEMVHQFGHFLFVYTVFSGHYLIKFPIAVRILSPSFFAFGCTTLLLFFTSIDRLLYVLFPLRTAQYDNAIICCVVLPIAGMFGAFYVAPSNSNSNQLNMRIFRSLFIIVSMNISGYFVFDFFIAISKIMPMPNLASRQCQHILSHPLHSLQVADARVINPNLGNAYAKLKAKLGYSDKLLEQHIANEFNKNILGHEKPLPPAVVDQLLMLSISFAVRLFVSFKFHYYVFDKDRESFDKWQIETLLSAYKILSTKSGTNWICPFKIIQCHEHTAEHDQYIQNFKFVLKLSDFSLTSFEVYKLSEIILIEAERIIDDKSNNNVQAFEQQPLALYTFVKQYFVENIGKKTTPVPKSMEKLVHCALLSFGRELLFRVSLTYKEFRNYFFAKREDECKDVYSTEILDSFMLAFFNEPLRNYPSVIQINVDQCKGVRQFAETLPFKKYSDKVKYDENVQIMSLPPKLAEHFLERLFTLTESKSASICEIGTELDFVQTMQNFPDYLQKENIEKLRQEEVQENFLVMHMPNSTPTTFYEMLKEFCVLAHFIEDLLEEMASGNKIPKFESIEIAIGHFILVKEELCKEKSIEKDLKKYFGENLVNFGKAINIDFSPHNELHQIGREIIKKIEQMLQNDDWNYAYLNNSKMDEWNLLEYDLRKMGNDQKWEEIEQFRNEWKKAYNKWVYNKFAEERPSWILVVFASIYTFVATVGIVMNFLVFFVTIRTKFDPIKPASPSSDARESRDLDGSANKLLALYSLFEMVHQSGHFLFVYTVFSGHYLIKFPIAVRILSPSFFAFGCTTLLLFFTSIDRLLYVLFPLRTAQYDNAIICCVVLPIAGMFGAFYVGSLYLNAGSLNDKLIIGTLSDVGSFVSIQCDNWMQSIFFEIVTILLLATIVIYALIAILLYSNKAPSNTNSNQLNMRIFRSLFIIVSVNISGYFVFDFFIAIILPYFVLLPMAYWKWNQIIGIVLNVSAASNAPILYLTSSEYRKAFRKELKPFINIFSRNSCPFQGDGIGIRAGDARLTTQSSELGLLPDPSKEESALLVGIEQYTGVFSSGMNTSVRNPQIYPDMDGYGYKIFGTVADTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLX5</accession>
    <name>A0A914HLX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g1999.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1999.t1"/>
        <property type="gene ID" value="Gr19_v10_g1999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037552836" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1594"/>
            <end position="1628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1999.t1"/>
        </source>
    </evidence>
    <sequence length="1628" mass="190253" checksum="154B2C0684E597F7" modified="2023-02-22" version="1">MKAQMLTLIFIFFINYLENSVGAPSPPQWDLINSGNNVQKFAQLIEDIYKQSQLAKLAFNLTFVKYASELAKFRVIDNNEEMRPTFKAYSGVLLGIQDEFVGFRHYSYNLDNFIANEFNKNIFCTKKAIPKKVVDQIMQLIFSFAARILLSVTYKTSIGIGEWQLQTLLSAYRTLAAQNDNNEDGIFPFPIVQIDANGDHLWAEFINQNISKQFIENFNFVLKLSEFSLSYYDVYKVLEAILIESNAAAPSTINNNNNNNKHLPPNDEPPPAVYAFLKQYFVAKLDHKSMGQSNVKKVDCAFVHFGRELERRLVEHTSRIDYPGFAGYVQRMEIECGKAPHIQWSTPTKNMPSPRSKQLEMELFHEPLWNYARAIQIDSHACKVVLQFADALIPKFGQILFETFNKSSDNVKYDETRQLLSFPSALSNHILRRLNVFVQRAKSASISNFGDKLDFVKTIQNIASMDKIEFKQRKRIPRPENSELFNFLFTLAIRLSLQIEQNDLAEKYLETFLFVVNQSFGEYTSSGVFALKIRNINKMVEVNLPTWKLPYFIYLENRKELEQENALKNFKFIHSLSEYSPTIYEIIKMANILGDINDGQIWISPSDSEIFLKVLEYLTGQEKPEEQIKVPIQKEFCILAYFVEDLLWKAAEKNNFLFDGSKEELFRSFILEKHQLCDDKPKEEEIRKHFRDMLQYANVIQVQIDPHKELQQIIPPIIEELEEMLQKGEWNYANLNAMIRVEWILLKFDLERLGQIADWEQIDKVGGKWRKMYKKWFPKKEDNKQIMKAQMLALALIFIFFINYLDNSVGAPSPPQWDLTNSGNNVPIFAQLIEDIYQQSLQFIDVYVPFKLELVKNDKVSFNFTFVKYASELANFRVIGNNEEMRPTFKAHAGVLDFRDEFVGFRRYSNKLDNFIANEFNKNILCREKAMPKKVVDQIMQLIFSFAARILLCLTYGNYYSYDGIGEWQLQTLLSAYKILAAENGIFPFPIIQIDANGEHLWAEFINQNTSKNTSEQKQYIENFNFVLKLSEFSLSYYEVYKMLEEILIESSAVPTSTINNIHFPTNPPPPVQAVHTFLKQYFIAKLGSKSMGQYIDCAFVHFGRELERRLEEHHRIYYPGFAGYVGRMEAECGKGPHLNQPYWSTKTKNTPSLMSKQLEMEMFHEPLWNYARAIQIDSHACKAVLQFADALSKIVVNFELNSDKKNEYSIDGITKLNEFKLLLRIIDGIGDTENYEKLENFENNSKKHSLNELSTLLKQIIKEYSCTNSSCPLHGHFSLSRNQEILSKFGQILFETFNNYSDNVKYDENQQLLSFPLALSEHILGRLNDFVQSLPTSITDIGDDLDFVKTIQNIASMDNFEFIQRKRIPKFSNRKLFKLLFILTIRLSLQMEQNDLAEKYLKTFLFAFNQSLGEYTSSGFFGFKIRNINKMVEVNLPTWKLPYFIYLENKKELEQENALKNFAFIYSLSKYSLSIFILEKQQLCDDKPKEEEIRKHFRDMLQYANVIEVQIDPHKELQQIIPPIIEELEEMLQKGERNYANLNAMKRVEWTLLEFDLERLEQTADWKQIDNLRDEWRKMYNEWFNNVDDENGEEKQKEKEGEGKQKGKDGAEKQKGKKGEEKQKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM78</accession>
    <name>A0A914HM78_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HM78"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2077.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2077.t1"/>
        <property type="gene ID" value="Gr19_v10_g2077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="442"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2077.t1"/>
        </source>
    </evidence>
    <sequence length="533" mass="58892" checksum="C782145DF0504E75" modified="2023-02-22" version="1">MLCRRQNLSKIGTTICSKWQHRRSLSSSNFVELAGFTASTDSKQYADKKLLLLQDGRHMSYNDVNVASGRYAALLNKQYGIKRGDTVLCRTSKTADALALYLAVLRLGAIYVPLNPTYTKRETEHFVNDAKPTVMVTLNAQDDASFTQSGFDVKHVLCEHKLAGEALKHEASCEVEAAQKDDVACILYTSGTTGRPKGAMVTHGGLAANAETCTEIWHFGPNDVNLHVLPFYHIHGLFISFNCTLMSKSSCIFLPKFELNETIAYLPKSTIMMGVPTFYARMVEHSGLNGAAVKNMRVFISGSAQLTPQVFEKFEKMTGMRILERYGMTETLVSTSNPYDPVNTRTAGSVGPAVKGVHARINNDGVIEVKSPSLFKGYLNLAEKTKQEFTADGFFITGDMGEIDENGYIWIKGRQKDLIITGGLNVYPTEVEDVVTNIFGEKLKECAIIGVPHPDFGEAVVAVCEASDSFKDKLNGAHKLTADEKKAFQELLAPYKIPKAVHFMPLPRNHLGKVQKNLLRAMPELKELFAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HME9</accession>
    <name>A0A914HME9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914HME9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2832.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2832.t1"/>
        <property type="gene ID" value="Gr19_v10_g2832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000006">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="341"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2832.t1"/>
        </source>
    </evidence>
    <sequence length="751" mass="83834" checksum="3BA178E61558F38A" modified="2023-02-22" version="1">MSNLDNPGIFYQDRVFSNDAADNVLDGARELVAEYKRLDDIYQRFIREFSIGGLSFKYREDLKLNYTLGNYSLSVDFNDLATFDEDAAGKIKRYPTTFLPALESAVKKVVDDITHPRPPGDEEVHDVQVIVNLSDKALGIRKVKSSDVSQLVKVSGIVVSASQVRSRATKVTLQCRTCRHTIADREIRAGLEGFQLPRQCQSANQQAAVGGQRCPFDPYMVLPDKCRCIDFQTLKLQELPEDVPHSEMPRHLQIYVDRYLTDKVSPGNRITVTGIYSIKRITGGKKSGKDDAKAGMSGIRTPYIRAVGIQVQMTGLGRADQMHFTPEEERQFKELAKDPHVHDILTRSIAPSIFGSDDIKRVIACLLFGGSRKRLPDELTRRGDINVLLLGDPGTAKSQLLKFVERVAPVAVYTSGKGSSAAGLTAAIIRDPHSRSFIMEGGAMVLADGGVVCIDEFDKMREDDRAGITTTLNSRCSVLAAANSVFGRWDDSRGDENIDFMPTILSRFDCIFVVKDHHDGAKDLQLAKHVISVHVRAMDPQAQILAVDGEGTASQTPHSQPMAPNGELSLEFLKRFIAYARANCAPRISESASNKLINQYVQMRNMPTDHQQKRSKKHPHAAIPITVRQLEAVVRLSESLAKMELAPFAQERHVDEALRLFKVSTIAAAQSGNLSGVEGFTSTEDQEAFNRVEKQLKKRFQVGTYASEQLIIEEFARQGYPEGLVRKAIEFYVRRGDLQYRMQRKLLYRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN90</accession>
    <name>A0A914HN90_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cullin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HN90"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2869.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2869.t2"/>
        <property type="gene ID" value="Gr19_v10_g2869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000091">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000006">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="863"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2869.t2"/>
        </source>
    </evidence>
    <sequence length="1261" mass="144248" checksum="F454C48BF3C8D6E6" modified="2023-02-22" version="1">MSNKKRLINLASELFSCSPKEVANPLQFTSNQNILEKAINRAMQRGASLQYEKDNGQSEQLNKNNLLVVADRPLWGTRPVVSHRRFAFQVLRLKRIPGSCLGPMVMTGGRYYPLGGLALWDFRDEYEEFGEFQKFVEEWENQEKEISRKATERERERPESNAEFEIEMGQAKLSTKCSKIGREYELRGELGPSDQITIKVRGKGKFKGCLTVLSICWVMVTMAQAMDKPREKAGPLSSDEELFDFEMQQWEHELGDLTTGPPENREGVETANPQGQGERANASGQGLGVEAVLPVQQRVSGVAVRPVGTPANGAAVQFQINASSWAEGLRNAVFIPLDQRPSTSTGCRRETNSSGMGIESDRHAIGERARQWDGRSRHPRARPNRTETPYGFRTRPIRANPPEREEQRDVQPSPARLQIPQGSPSLQIPVGIRRQFLRRLSQEREHTYGLAQLIAQWNPALSLAFLSLEMFYSSLLAQALDEGGAGPTPSKVAEAPRDPDSVRNFDVLMPNQAQQPSKSSMRIRAFPTNVDDSYIVNTFEELYRNAYTMVLHKHGDKLYEGLKEVVREHLQTRIRDVVVESINGRFLEVLNRVWTDHTTSMVMIRDILMYLDRVYVSQANVESVHPLGLRIFREEVVDYPVINEHLKATLLGMISLERQKEIIEWIDLKNDLFLRETADFYRRASQKFLAENSACVYVHKVNESLIEEVQRSERYLDKITEAKIIDVLNDELISRNMTTIVEMENSGLVYMLLNDRIDDLRCLYELLKRVPNGPKTMTNTMSSFLRAKGTAIVNDNTQQQQQQQQGEVAEGIGGVPNPINFIQSLIGLKEQFDRFLLEAFNNDRDFKHCIQSDFEQFLNLSLKAPEYLSLYIDDKLKKGLRTLNESEVEVVLDKALVLFRFLQEKDMFEKYYKQHLAKRLLLQKSLSDDAEKSMISKLKTECGIQFTSKIEGMFRDMELSSTIMNDYRSRTDLDLAVRVLTSVFWPTNQAPMCTLPQSAEQAFRHFEQFYLGKHNGRKITLNPGLGSADVKAIFYPNGPSKSSGLTSDAGLGSNEEDLESQQESDMPGSSSSKSTVVRRREEQKILTVTTYMMCLLMRFNQHARMTYEQLLNETQIPDRELKRCLQSLAMGKQSQRILCRKGAGKDIESLDEFFVNDQFSSKLTRIKIQMVSGRSETEPERKETRAKVDDDRKHEIEAAIVRVMKARKKLLHNDLVTEVTNQLKGRFLPDPVFIKKRVESLIEREYLERDKLNLKIYVYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNB3</accession>
    <name>A0A914HNB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 14</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HNB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g218.t1">
        <property type="protein sequence ID" value="Gr19_v10_g218.t1"/>
        <property type="gene ID" value="Gr19_v10_g218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g218.t1"/>
        </source>
    </evidence>
    <sequence length="605" mass="70369" checksum="68A9AB91D4966B68" modified="2023-02-22" version="1">MEMLSAEDERVNFDELLVSIKSTRNVNEIKEKLDREQKRAATGQERRHGKTKKAVQQKRRPATEAEAELEAALEAQQNERRNKKVLEAPLHRQARNRIESRLAYRQTKEELRPWDPIVEGLRVAEQLQFPHDERRDDPLRTLTAEERAKTFTPRTELELRMAEVLNGSKHAIRDGEQYSRAERELLKAMDVTEAQRKCAELRRMRALMSFQASKLKRQSKIKSKQFHRIRKRQQRRELVKEVEQLLVKDPEQADEKLKELEKDRAYERATLKHRGTNKWTKQVRKFAARDPQLRHKLEDQLRLGRELKRKNEAVALGDAANDDDDESDKNSEAANFGEEEEKKHLVTTESGDLDAALNPFYRSALENIRRERKTVSKQARAKAAKLSRQHNAIAEVAKNGPELDETEEEPTPFLDLNVRPILQVPQELADGADSDSDVQQAFQAEAYADDDVLGEFQRRKERVETQEKPKAKQSKYLRGWGAWTGPGISEEAEQRRELKVFGQQPVLKARRRKDANRPGVIIREQRASEGIQRLQPRDVPFPFTRIQDYEAYVRQPLGRDWNTPIAHQQLTKPSIVTKDGRIIRPLNKEVKKHKQMMADIIGENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNC9</accession>
    <name>A0A914HNC9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNC9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2371.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2371.t1"/>
        <property type="gene ID" value="Gr19_v10_g2371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2371.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28677" checksum="6A4B3EC539A4E6B8" modified="2023-02-22" version="1">MNPENDFGIFSVSVLYRNPDTEYRKTPICRTLILTESINGEITADTELLWLTFANLDPSEEFGKEVWDADTLGNRNKIEAMQLELNEVKEELKQYKEELKNTKEENKELRAELAHQKQLNACKCMTSKDTKMEEYQNKQQQNQEENKKLNNLMEEMKLKQQQDQKETNDKIGWLNEDQQKLVSIDQFSQVQTAISDLEHKQKNDQETLMRLKSVQSMALTLRIIRRQISLWGSNNRLRMLMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNF3</accession>
    <name>A0A914HNF3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNF3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2394.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2394.t1"/>
        <property type="gene ID" value="Gr19_v10_g2394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2394.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="30012" checksum="F71A867BC138B023" modified="2023-02-22" version="1">MIHSNECAKNARKIQFLFTDRKVIVRNESFGIKTLNCPIGTPTIELSPNIMKKMERELLAIKEELKNAKELLSKNLEEMEEWKSIVKLEQENRIDQLRQEIAKMEQYQNEQQQNIVDLQKTVAALKEIEQIPQNRWDPSACHEDLTLSPDRLIVEHNGEISGYCSVFAERKMPKKDSGIFYYEMEMLRQEGHVRIGLGAKPMPMQRMDDWIAFHEGTYAYQSDGVFMGHDDGLRLVSATSSAAAWIWQLAKSFTRSMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP30</accession>
    <name>A0A914HP30_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP30"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2380.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2380.t1"/>
        <property type="gene ID" value="Gr19_v10_g2380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2380.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16290" checksum="6DD7BF2B93F92298" modified="2023-02-22" version="1">MSPQYDTHKPSNAHIGVMSGFCNSYIEASNKRVQAGFGIIEEKFTGQFQCTFQSCNKRLKNNVMFMYHIWAHVAQQKPTKNEEQCSNLQNLLAEHNGAEDEAKTDAQRTDVSRLHTCPECLLEQPTPYRARLHYHLPFFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPR2</accession>
    <name>A0A914HPR2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein Rhes</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPR2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2576.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2576.t1"/>
        <property type="gene ID" value="Gr19_v10_g2576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2576.t1"/>
        </source>
    </evidence>
    <sequence length="442" mass="48947" checksum="902A05943DBBE4A1" modified="2023-02-22" version="1">MLDSYPPFGADAAAYRRRPSSANHCNPKMPEAVEPTIAEKYTSNRSDKMLRNASQPRRCNSQRVPSANHRISLGAITATTLTPQSSAVTTDNGNNQQYEPHICVPNRHAVERSQSQLSQPSGTRVLDQPHEAASQRRSRRSYDVNAQRRSPMNGAGLGGPGGIADQTAHPQTQLTLVLMGAPRVGKSALVNQFLWEGFLNDYRPTVEEFNWVEYGSDEPDTPQLLLQLIDSSGSRDFLAMRHLYYRIGDAFMVVYSVNDPNSFDEALIMIREIEQYNSKNAPILLVANKSDLLMVSDSPSNLSDSNGATGGGCGASTPKSMASTTSAGGRLETDADTEHQRLLNSVRRMRISAKNLEQVKGAFTWLIDTLVRRSQITTLPLRDSRSSDANLSTAASVRKALTRRRQSLPSRRTASELGIDEETLRRLMRRHDKQQRHACVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQP4</accession>
    <name>A0A914HQP4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">5'-tyrosyl-DNA phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQP4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2818.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2818.t1"/>
        <property type="gene ID" value="Gr19_v10_g2818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="12">
        <location>
            <begin position="103"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2818.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43400" checksum="30D8FA9CE534907D" modified="2023-02-22" version="1">MSDLTDDDAEEVIRQFAEITETDEAFAHFILQDVNFDLERALAHYYSADDPETAYKNFRRDNGDSGGTMSKSAGNEGKQPPRKRSRPADDPQNAAFPAELTLVSWNVDGRDERSLSKRFLAVLYIIARTNPEVIFLQEMTTELMPRLSELMSPMYNLVVSDTYNPQYFCVTLVSKNIRVTHSEVIPFSNTQMGRSMTVIQAQWQRLRLVLVNVHLESCREHGEVRKAQFKRCMEKIGTTVGSDAAETLAVFGGDLNIRDKEVAEVKADAAANLPEMRDAWEAAGSDGSLRFTWDMCRNDNYRDRGRARCRFDRVYFAGPYEDVEFNLEGTSRIRGPDCFPSDHFAIICRFVSPRNVQDQTANATSAARSSSTSTTTAATVAQMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR49</accession>
    <name>A0A914HR49_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chloroplast protein-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g3875.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3875.t2"/>
        <property type="gene ID" value="Gr19_v10_g3875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612:SF0">
        <property type="entry name" value="CHLOROPLAST PROTEIN-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SecA family profile" evidence="6">
        <location>
            <begin position="675"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="780"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1676"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2014"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2242"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2312"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1676"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2028"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2081"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2132"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2150"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2187"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2242"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2312"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2324"/>
            <end position="2335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3875.t2"/>
        </source>
    </evidence>
    <sequence length="2813" mass="315647" checksum="333B0E6635389395" modified="2023-02-22" version="1">MRPLWGPQSYSSSHMQHFLIPSGHWFFVLLLNLLIPIQIHRKCVKVQQHTILSPRARARQRLALQEQQRRKRDAEEREAVVARGIEAVQEVQKTETFLDLDFQQLGNTLKQKVALSILKARPNASGGPTQFSAAAFMPHGNVPSKMDNGDGNRSFSSCRGKGNDDDDQTVAERTDQQISDVCAQLRAHLEELLQLRQHCIDVRTPTEKANLILKQIPDPEQDIRINDEISDDEEDVKECAKVETTENSDYEDESSADEEDYNPRVSRCRRALRAIKLPIILAICAKTEDAFLDNSDKVQSIIAKIEALRVPGAGAPMEDAKRRSRQVQELLKDFGRISNFVPLLANEEQTMKDLFETAQNTAADHSDGFDGNQKQLFGEEMQNAKKAYDALLKHNLDKLKQRFLENCVKTMKELPTHKYIPEERELLDNFLANIYNALAIQKKLRLEAFEGEERQRKEQHRRTWRCSSTAAPKPPKWGEEYACDVIYGTMQDYPSQEAYDEFFGKDVRGGRRIDAIINDEGDFSKIYENLKQKGGQKDDDDQHESKNRADEITSRQHILTMIKEFNDRWIRQLEEAENCPMTSSKLELLNEFKEAIKRAQMIYENFLQKGGQKDDDQQLSFAELVEKIMEDGGGFSAVLKHMGESRLKAVNGNLRKWLGDSYNKFKQECERFGDFVAEEIKEWWAEHKSSPEGESRLKAVNGNLRKWLGDSYNKFKQECERFGDFVAEEIKEWWAEHKSSPEGTTFEQKLALIAKGVQVISGFKPRNTQLLAVMLRRFVAAECPEMHGLMLQVATGEGKSWIVAMLAAMLHLTNHSNKRGDQQIKDDEPMSGQGMLVGVITSNHHLAKKDAEEMANFFDLFGLTVSHIVLEYSDEESLREAYACDVIYGTMQDYQSQEAYDEFFGKDVRGGRRIDAIINDEGDFSKNDDVTQERELRLATNSPGMESLNEILMFVALARDLILREMKNNGTLTEKDGNATLTAEQVKEVKANMIKFIDQFVEHAEETNNKEKMPPNVRQRRHRRQIPVTARGTNANEKEEEAEENDLRKELAEMAPKIPKHLLDFVKLEIEGWCSSALQALGLNDKVQYIMETENNNGTTNNNGTTNINGTTTNNGLPSAMTPMRIIPVDNMNSGIIESQSQWDKGLQQIVQIDQQTEITPLSLQSAYKNNVGFLCPHTNMTSITGTAGSNNERDFVGNIFKLMTINVPRFKDRQYTKDADDKLCENDAEWTESIVEKALEYTDKRAVLITTGSIEDANTIKDALAARIGQSKRRIRTFIKGRTDEESESLKENMCQGDILIGTMLIARGVDMNPADDVLRNKGLAHITAFPPRNNRVEEQVAGRVARKGQPGSGCLIIRKSDIKRLISDGGGCQNEEWSDRDWENWRDKREALVADQLTSFLQNRIPILSFRDELYKRMCDKMGEVRSICEEEEDYCQYAAVQIQELWSFWINRFDHEIAALIEEGKKAGKTVTDVLDGPTKDGFFRRFDEFIESKIGQLKEFVADPSKSELLENPAYLMKTAHLMLNSEHPEIAREMIKKVDPNDPEFAYIRLYYEAKAHVELGHKLFLRHNKRRPKNRELHEKALKCLEEAVKIVDNKMASINGVLSVLNIKPSSRLSKQFHRDIEALNIFRQQCLTSFNTIVRIDQQKVGVAKIKDCVEIDDAALKYKKEMKEAKKAEKQQKSAATEPPRTANPSGPDDPPPDEPAAAEDGNGDDDISIPKDELEAMKDEGLSHFYNLDIAMPIPSMWTIGLLFFAGVLQIGFGLMLAFCSSGAATQWGWSLINGGWDDVLTSLTMAFDRLKGKESPAFSWAKWFAKKVVHYGKVVLGIFKQSLTAMLPEDNKFCKFLEKNPNFAQNIQMGAGLVMDSGLDIKEYYKSSKTLPYSKGLTRSLAQKVLKREVARKLVKRSVAVGCQMGQRVVDKKFRESCSKKRAKKGDNGGNFWSHLFEEAVSAVITSDLIPNATVNLADKAFTHAMKYDKMQEKFDECVFLEDREESGMTATQARECAEQIKKKNGGKWPSGTKREEKGDRGEGTKGSKSKKEGEEAGGSKSKKEGEEAGGSKSKKEGEEAGGSKSKKEGEEAKGSKSKEEGEGAKGSKSKKEGEEAGGSKSKKEGEEAGGSKSKEEEAEESKEEGEEAQHNGVKKFENKGKRKEELDKAKMQQRAREMLAKGAKKVGNGAKGERNGAKEEGEGAKKVGKESKAKRVKEAQQACNKLILPTSSERNELEKALKKLEDEAEEIEKGRANAEQSSNAETDGSAPLGKLWIIPPNSLPSIVGRPLHLRNYNNLPFQNDEAIQFVTNAPQSSKAQSVGSPTNVAKSSAVSSESAPLGCTRDGGSGHQGTSASDDQHGDVEQATINYWPFFLPSNAADTLHLRNYNNLPFQNRRPCTDPNYKPTISSAQQQLVKRGKLKVVLQRVTEEEVVAAELSHREQHRFNHRQRAHYAVVKSVKNGLRVINALGVLNDLGTVLQVCIQQGGEAALRKGMEIVVGRVGQTAAVGLVSSAAVATGVPFGLAAVCQIAMGFSAGKVIEVALNANEDRQLTGTTDEESESLKENMCQGDILIGTMLIARGVDMNPADDVLDKGGLAQITAFPPRNNRVEEQVAGRVARKGQPGSGCLIIRKSDIKRLISDGGGCQNEEWSDKDWENWRDKREALVADQLTSFLQNRIPILSFRDELYKRMCDKMGVGRSICEEEEDYCQYAAVQIQELWSFWINRFDHEIAALIEEGKKAGKTVTDILDKPTKDGFFRRFDVFIESKIGKLKEFVANPSKSELLEKPGIFNEDGAASKLSLATVPNKNSPNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HS21</accession>
    <name>A0A914HS21_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HS21"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3712.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3712.t1"/>
        <property type="gene ID" value="Gr19_v10_g3712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3712.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16350" checksum="87C8B49D4EABD0CD" modified="2023-02-22" version="1">MSAPIQQKLGAALKILSNVSSAVKLNLQPDKNLSNLENALLLESQLEKVQKEGRTLEIFLEDIRESSSAWTDLLRKFTATERDAGEADFAAFDKKEKINDKVEAADTKLRDLRDLAGKLTVQAKLYRSRANSRPRKNCSNNTAKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSN1</accession>
    <name>A0A914HSN1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSN1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g34.t1">
        <property type="protein sequence ID" value="Gr19_v10_g34.t1"/>
        <property type="gene ID" value="Gr19_v10_g34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036789505" evidence="1">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g34.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11224" checksum="453EDFDDEECA2167" modified="2023-02-22" version="1">MPKLVIGILFGYNLHLILGCEVEFSEPGQKEILIKASECAAKRWKLLTVAKDESGTLTVVDEAYTKLDGIGELTIHIGDELQPRLQQRLGIVCSEATLNLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT79</accession>
    <name>A0A914HT79_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4000.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4000.t1"/>
        <property type="gene ID" value="Gr19_v10_g4000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4000.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9835" checksum="07627B95CDA6294C" modified="2023-02-22" version="1">MLEVDVDHLLVFVQFDEHPDFACVLAKRLLQCAVVVLREVVWSDHSRQIEPNSTDQNPPLTESDHFGQIEPNSTDQNPPLTESDHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTU5</accession>
    <name>A0A914HTU5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTU5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4407.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4407.t1"/>
        <property type="gene ID" value="Gr19_v10_g4407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4407.t1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60916" checksum="D07FBEDCC4A41E7E" modified="2023-02-22" version="1">MLFCTTLAVDVPKSSTTGDDALLLKLEGVAKQFAEQIGHCQFTFGPLPFPEDIQSPQKRWEATRQEATLTYACCKRPRRRRREAAHFAEENLPTAREGYQELRLLNHRVCLLRLMANLREKAAHTFYFMPGFIGYNEDVAKNMIALYKDMKNQTLIDAVIDGELLLDKTNSTSSSSLHGNLLASDGKTAMYFIIQTWDKSLPECADDSFGHVMIKNGNAMDRTAPTCRPKWELSRNALDECCRENMVYTITMNDSRIIRGKRSFNCFSIRLLKRYKLLDKYAITKTITVKSPGSPKFAFVTAADDAHYPSLRRLLANIKENFGCNQKIIAYDLGTISKNNEWMIEINSVCNLEWRVFDFAQMDEGPVSNLESNAWKIFILAEVFSKFDTFVWLDTSILFDSNNLAKFLKQIPRKIGSVQLPSYSGHGMNFATHPGMYEFLPLFTNYEANKTYELTGNDDPPQFEGDASFLPQTSRDHPRSTQQSHGIDGLFQVNVPLQDISTLDVSTLDISTLDVSTLDISTLDVSTLSFKSCKKGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU47</accession>
    <name>A0A914HU47_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU47"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4003.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4003.t2"/>
        <property type="gene ID" value="Gr19_v10_g4003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43907">
        <property type="entry name" value="SLEI FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4003.t2"/>
        </source>
    </evidence>
    <sequence length="1275" mass="139333" checksum="41E02AE64A230F75" modified="2023-02-22" version="1">MLAQANNMLAQGNNMLAQRNNMLAQGNTMLALGNTMLAQGNNMLAQRNNMLAQRNNMLAQGNNMLVQENNMLALGNNMLAQRNNMLAQGNNMLAQRNNMLAQRNNMLAQRNNMLAQGNNMLAQRNNMLAQRNNMLAQRNNMLAQGNTMLAQGNNMLAQGNNMLAQGNNTLAQGNNMLAQRNNMLAQRNNMLAQGNNMLAQRNNMLAQRNNMLAQGNTMLALGNTMLAQGNNMLAQGNNMLAQRNNMLAQGNNMLVQGNNMLVQENNMLAQRNNMLAQGNNMLVQGNNMLVQENNMLALGNNMLAQGNNMLVQGNNMLVQENNMLAQRNNMLAQGNNMLVQGNNMLAQGNNMLAQGNNMLAQRNNMVQENNMLALGNNMLAQGNNMLVQENNMLAQGNNMLALGNTMLAQGNNMLAQWNNMLAKGNTMLAQGNNMLAQGNNMLAQGNNMLVQENNMLALGNNMLAQGNNMLVQGNNMLVQENNMLAQRNNMLAQGNNMLAQRNNMLAQGNNMLAQRNNMLAQRNNMLAQGNTMLALGNTMLAQGNNMLAQGNNMLAQRNNMLAQGNNMLVQGNNMLVQENNMLAQRNNMLAQGNNMLVQGNNMLVQENNMLALGNNMLAQGNNMLVQGNNMLVQENNMLAQRNNMLAQGNNMLVQGNNMLAQGNNMLAQGNNMLAQRNNMVQENNMLALGNNMLAQGNNMLVQENNMLAQGNNMLALGNTMLAQGNNMLAQRNNMLAKGNTMLAQGNNMLAQGNNMLAQGNNMLVQENNMLALGNNMLAQGNNMLVQGNNMLVQENNMLAQRNNMLAQGNIMLGNNMLAQRNNMLAQGNNMLAQRNNMLAQRNNMLAQRNNMLAQGNTMLAQGNNMLAQGNNMLAQGNNTLAQGNNMLAQRNNMLAQRNNMLAQGNNMLAQRNNMLAQRNNMLAQGNTMLALGNTMLAQGNNMLAQGNNMLAQRNNMLAQGNNMLVQGNNMLVQENNMLAQRNNMLAQGNNMLVQGNNMLVQENNMLALGNNMLAQGNNMLVQGNNMLVQENNMLAQRNNMLAQGNNMLVQGNNMLAQGNNMLAQGNNMLAQRNNMVQENNMLALGNNMLAQGNNMLVQENNMLAQGNNMLALGNTMLAQGNNMLAQRNNMLAKGNTMLAQGNNMLAQGNNMLAQGNNMLVQENNMLAQGNNMLALGNTMLAQGNNMLAQRNNMLAKGNTMLVQGNNMLAQGNNMLVQGNNMLAQGNNMLVQGNTMLAQGNNMLAQRNNMLAKGNTMLAQGNNMLQFGNSQSKQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVJ5</accession>
    <name>A0A914HVJ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVJ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4379.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4379.t1"/>
        <property type="gene ID" value="Gr19_v10_g4379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4379.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24275" checksum="ED43572563CED9AE" modified="2023-02-22" version="1">MIVKMPGQCVFLVSMRTLSPTGNVETWLALAVGLGLVNALSPLHDKGFIHRYVTPWNFMVPMPFSMDNIVKRMVIMDLSLATRWSPEMAYDAAVRFAGTVKYSSERALNRRTVGPADDFISVIFIVAELISGKLPWRAVSKIDKCAAMREKFTETDEFRRLPREIRKLYGKLCDSSPSDKPERVHEAFESALDRRTGSSLWSLSAMPAWLEMPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVZ3</accession>
    <name>A0A914HVZ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HVZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g451.t2">
        <property type="protein sequence ID" value="Gr19_v10_g451.t2"/>
        <property type="gene ID" value="Gr19_v10_g451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000663">
        <property type="entry name" value="Natr_peptide"/>
    </dbReference>
    <dbReference type="SMART" id="SM00183">
        <property type="entry name" value="NAT_PEP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g451.t2"/>
        </source>
    </evidence>
    <sequence length="644" mass="68542" checksum="04A1B56506D3CEFA" modified="2023-02-22" version="1">MELDVLVAGDWLPGMELDVLVAGDGIGCAGCREWNWMCWLPGMELDVLVAGDGIGCAGCREWNWMCWLPGMELDVLVAGDGIGCAGCREWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGSGDGIGCAGCRDGIGLDWMCWLPGMELDVLVAGDGIDVLVAGDGIGCAGCRGWNWMAGCRGMELDVLVAGDGIGCAVAGMELDVLVAGDGNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDRIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDVLVAGDGIGCAGCRGWNWMCWLPGMELDFRTFVFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW51</accession>
    <name>A0A914HW51_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HW51"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4318.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4318.t1"/>
        <property type="gene ID" value="Gr19_v10_g4318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF28">
        <property type="entry name" value="SGNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036906322" evidence="2">
        <location>
            <begin position="24"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4318.t1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54746" checksum="D8361253E7D94089" modified="2023-02-22" version="1">MLIQNAFSIFLLLPLLIPHISTALHHRISASFGSNKHWHARMPEKTDDALLQAWQELLALQTNQSAVARRDHPIDDRLLTPLHKCASFPFHAARVEDNDDYDNANVVRMRSSASASTLAPQWVEIYGEIGALTSVCAEERAATRTTMDVKELAEEFRNKCTTGWQMPSSSASDSVVPLSLVQMFNSIGARVEAVHGDEPSAHRNLQAWTRAVVDKMRTLRAYATRWKLLLIAPGLHGEHQKRIYGIPAAALVQDVLQSVQLVRHGLPRRTFLLILRQSNLSFWRSVAKTAAFCSKMLSLWELGRAEDDETAWDVLEARLRAVYGDDEEFHVQVVDILERARPVITTSNFANISPLASDCVHLSPRGLSLLHLQLWNWLMQPRLRHVHPFVPLLRPPLCPRPHCPFLATARNSISCPRLPLLMPQSIDANQKATFPLNVSVMLSPFSVLLGFSFSFPLLLSLVAMCSVIRHRKCFSIGDNCRGAEVIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HW75</accession>
    <name>A0A914HW75_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HW75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4588.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4588.t1"/>
        <property type="gene ID" value="Gr19_v10_g4588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4588.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="33674" checksum="60B0EBC0F841EE8F" modified="2023-02-22" version="1">MHTLPHTDDDERTDGRQSLCVCVCVCVYSFLSWCCLVGADAVVGWVVFVLVVVVVVVGGEEREREREREERVIEAFWGTGDGGGEEAGEEAGEETGRRRGRRRGGGGEETGRRRGGGGRGKRRKRRRGGGGEEAEEEAGEERGRRRGAGKETEKEAGRRRGRGGGGGGEGGEEAGRGGGGGGGGEKAGKETEKEAGRRRGRGGGGAGEEAGEERGRRRGRRGGGGSGEEAGEEAGKEAGEEAREEAGEEAGKSGRRRGSRGGGGEVGEEAGEAGKAGRRRGSRGGGGGGEVGEAGKQRVQQQQQHNTAHVHGVHMMLCCVLVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HX42</accession>
    <name>A0A914HX42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HX42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4835.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4835.t1"/>
        <property type="gene ID" value="Gr19_v10_g4835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037356438" evidence="5">
        <location>
            <begin position="18"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4835.t1"/>
        </source>
    </evidence>
    <sequence length="488" mass="56434" checksum="5676B382CE091035" modified="2023-02-22" version="1">MFLFVLFFSLLFGHCCCESVALRLQINAKELPTTVNLDSRLDVVVVHVYRFYRNLFWSELLTSQTEHNAVQFGKCLVFRLGGTYSHEIRQTQQIDIQLKWYSNKFRSKPMPSIHNGPNNLIKLFNVRIFEPNLEALHEIYLGTSRRNTALSGQVNFGPEIDQNIYHMAFYIAKEEIVPSQNQRMERHPVGHFIVPSNLCHKNVQELGLTEHRSKKKIAFPFEFKVNLDNLYGYKLHNIQANFHQLETFEKPQNHQKAERQKCVICLKPLKKKQKITTLHVQHSFHTDCILKWIGNRATIKCPLCNLELPPYKVLNMALTLSENDLYFDALAKLVRISGDNRIAFRRRQAKHWLTHIRHQMDTKEAQIKEHLVSLGIKPVQTQSGAGGWSALRSWKQWSCYLAKMRNLFDFARGVVEPGEWVSQAKVKLRQMLAELSSGEPSQKVLASTVLALIEETEQMPESGAQEALETLRIVAEKMPEPLIVKKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXA0</accession>
    <name>A0A914HXA0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXA0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4632.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4632.t1"/>
        <property type="gene ID" value="Gr19_v10_g4632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4632.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23740" checksum="F01F4E60F02FED71" modified="2023-02-22" version="1">MGVFGLLQGMKNLLRGNSIHQFFGRGFAVQCVGGRSAGAEEVFNSERFGELSELMTLKLCAVSDTTALLVEFISDISVYLEYASTSGHCYQYTMAKWLVLSSLSQRQWGQLSACFFHYTQALVLKWRSMASERRDLMALALIPVELVRKAFVSASRQLDRARYWTLHPEEAAKPSRKKYVLKEGDLFAVLDAVDYLAPGEPHVTVRSLDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HY57</accession>
    <name>A0A914HY57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HY57"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5735.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5735.t1"/>
        <property type="gene ID" value="Gr19_v10_g5735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036688305" evidence="2">
        <location>
            <begin position="25"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5735.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21306" checksum="0E0C210994D25DEA" modified="2023-02-22" version="1">MPSPSSLLFSTIPIVCLLFNSCFAAPHPCCPGSQHLVALMTKYIGTFSTGKDESTVCARAESVVNAIKSELNSMPECQSPNGGGSRIVNEIDAQLTTSVHMKMEITNDDGCAYNLGFVRAMFDMAKSAAGHAGNGTEWNNLTESFRNQITEIDALSTELTIFVPNVHFQDPRSANFAHKKVPSPSDVRTNPGEYSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZP9</accession>
    <name>A0A914HZP9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">A20-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZP9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5523.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5523.t1"/>
        <property type="gene ID" value="Gr19_v10_g5523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5523.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="12844" checksum="70B2EF1C752D726D" modified="2023-02-22" version="1">MPSDDCHQQKEGNWQEVMNKFKSWVQKWPVAASPLFKEVGGSPLASEAAKSAADQRPIGIGATPCRNKCGLIGQTASEGFCPKCYKELLDKKVAQFTEKAAGTNKTTLADTLAASVITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZW6</accession>
    <name>A0A914HZW6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914HZW6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6023.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6023.t1"/>
        <property type="gene ID" value="Gr19_v10_g6023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF798">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="5">
        <location>
            <begin position="159"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6023.t1"/>
        </source>
    </evidence>
    <sequence length="387" mass="44149" checksum="507C0639A9D8955F" modified="2023-02-22" version="1">MAQQRKNPKEQQNPSIRLHPSSACNNDVLPLINPDTCRPLVSRSTRSPPHPDWMITKHQHPTQTIELPLDDGRPTRFHIQRWMMCHSGRTKNAKSYHILVVLLLSSSVTMCHCRPLLPDHLVELDFINASWLIDNTTPGKAATMFLGDQRFHKRQRRGSVVALESDKWPNGRIPYVLSTAYSPQQRAVLARAITAYNAKTCIRFVPKTPADKDYVVISKLDGCFADFARVGGKQHVSLADECVEYSTIIHEFMHVVGFIHEHQREDRDGFVQIRWENVIDGASADFEKLSAVGLSNYDEPYDYFSIMHYENTEGSKNGNPTITANAPEYTKLMGKSADFTEGDLNRVNRAYRCHNILLRRHPATSIPNTVQRPFSTPNFNMRTLWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0F5</accession>
    <name>A0A914I0F5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0F5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5459.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5459.t1"/>
        <property type="gene ID" value="Gr19_v10_g5459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5459.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17679" checksum="D43565B684A93F62" modified="2023-02-22" version="1">MPSCHYGTMMLSTNHEDDVQLAKTNLTKKVSAQLNTAAGDECSAEVGEQGNRKDEEDEHRCCTSHGDEDETDEEEADDAASAVDDDGVDAEVVENGTIDHSKTSPKGRRKGSHYGNHRNPTAESAIIKEFLDKAKDDFKQKWDNPASVGILISFQLFMCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1N3</accession>
    <name>A0A914I1N3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1N3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6054.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6054.t1"/>
        <property type="gene ID" value="Gr19_v10_g6054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037133990" evidence="1">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6054.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10734" checksum="DE6ED8E0E81468B3" modified="2023-02-22" version="1">MHSVAICICLILLNNLTLETFGCSDGDKARHDYHIIDHYAVGDKARHQNDIDHDGDGEGHYDIHYDGHIKKISQCNKILTPEECAKATFKVEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1R3</accession>
    <name>A0A914I1R3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1R3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6083.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6083.t1"/>
        <property type="gene ID" value="Gr19_v10_g6083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="359"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6083.t1"/>
        </source>
    </evidence>
    <sequence length="880" mass="97795" checksum="091B42F613311014" modified="2023-02-22" version="1">MSTKDAGAGRSLPTTFQSSRVDSTRNRGHTETTGAKGLALMQLVKKPKLLRKCFAEVQAIMEMSARVKRSYSTRGQCGADKHRKDGPTRAKRYYSNRTQLRTQSVICVRELSISTSCSSDDDETWARERPTKQVQHRCVRELSLSSSASSDGSDADELTGGSAARPARQLKQVTCVRELCVSSSASSDDSDADELKSAETPGKQQVEQQLCVRELCVSSSASSDDSDADELRSAETPGKQQVEQQLCVRELCVSSSASSDGSEEISGAEESLANTETFGDDGGSSEEAESMAVDARDDKLQQALNGSWMDNMLGMAHTTSMLGPKTRSRIWSCSLPAKHHSLLLHEQVSSKMLTEAEQQWLRLDYCKYKDRIVRAKHEIPKDTVICGYVGELISNEEYKQRLKKGVYNDSGRAGKLFEISTGKKGASHYIDVAPEYELASMGPAINHSCKHKANVRPRLKEIVADDTSTEAGDWNRERVARMVQGNKRTCKILSKKGVIFVTTKVIKKNEEVLWEYNVQCDIGDDIWLRCYCELGIELRKGAAYKQVRDSNRGPEHCGGGGSMIGGDTHKTLHSCFERSIRSDVVAVSSGHNVYTGQLEKTLLAIYKAATAWIQAHDFWQPLTKAKHYSVLHAFFNGVKQLEQAEMLPQHVSGLATAEWLDQMNKALQLIDVLLRTLKMAKRIEKQMHRAIQMFAEFQNAQRSFFMVPFMGGKTGRGRFICFEALVIRGIEAIIAYQQMHGQIPPVGLDSSPAISVFKDSNTNRTMRRHLKGRLGDETVHKIRHAATSAAKCYALASKRMNPFTADAIAPLAKMLDHSVPVSIGYYEQPTVEAQTTLSQYLLLKEMLVNDVQSTQIWYDIHVHADTPRFFSKLDVKKSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I313</accession>
    <name>A0A914I313_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914I313"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6364.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6364.t1"/>
        <property type="gene ID" value="Gr19_v10_g6364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="484"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6364.t1"/>
        </source>
    </evidence>
    <sequence length="669" mass="75941" checksum="36C627E95B046C82" modified="2023-02-22" version="1">MMTMPFGMKNATAAFSRAMAVVLSGLDGIALAYVDDVLIFTKEGNFEEHLAAVRKVLERFRLYNLKLSPKKCTFASKEMNFLGFVLNSAGFKPSLSRIEILKEMSVPTSVKEVKRVLGQAGFYRRHIENFAMVVEPMLKLTRQGNKFEWRRDQQEAFDQVKNLLAQVPNLVFPDYGKPFHIFTDASTVGQGGVLMQKSEVSGGFSAVSYCSRTLSTAERKWPAVQVELGAIIYALREFRPFIFMSDVELHTDHKPLAFLLKKSESSPQLARWMIELQNYRIKIVHVAGKENSLADALSRATEDKPFTEMQSIDELEDIIEFPVCLAISQHSRVVMDPFLNKLLVRQEDGGSYEVKLEEEQMKDPEAVAYIEFVRNGEFPAGLDEKEKETFAGGASKFKLDSGVLYFKEDGQPPKIYVPISLRGLIFESFHSSLLGGGHLNYRKTLAKCRKYFWPKMHSDILTWVKLCITCQLRHSPTPAYREEMMMVPANTLFAKVGLDLAGPFPMTQKGNKHILNIVCWFTKYVISVPVPDTKARTIAQAFLNHCYLKFGGCTELITDNATAFTSDFFREFCSMLYIDKKYACPHWSQGNASTERTFRTFHNILAKYISRNQPDFDEFLDAACFCYNTSVHASTGESPFFLMFARDPVFCVDQIIDPKVRDPVAIISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4A9</accession>
    <name>A0A914I4A9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase metallopeptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4A9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6485.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6485.t1"/>
        <property type="gene ID" value="Gr19_v10_g6485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037793742" evidence="2">
        <location>
            <begin position="20"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="3">
        <location>
            <begin position="561"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6485.t1"/>
        </source>
    </evidence>
    <sequence length="709" mass="80056" checksum="C1E420EB63C9941F" modified="2023-02-22" version="1">MKLLIINVFFLLIALKAFAVPGGHYSESTSWGACKLEKNGLFKLEKGCKTLQICYKSKLATGTSKFGGQFRLGKRVNERPLCDCAGVVARKEWHALNVSKISDRIFTIQSSLGLDGQFTSVFHIKPNDFIEAMNISKDFGPIETDFLKALHLGAFMKDFDGMAFRIMALDLLSSIGQNGTGLCKKTCAFEPTTLKEDHFGTNCTEIVFPAEVPKFVLNVLASPYLLVCDEHEFDIDSVEQLPAGYIENQYQDYVNACMQVPTEKCQFHVEVYACYKSTNKWPGNSSIAELCREHLGVDSTSNVAGFRVRICVHREGQFLVVESFFKLSFSDETFETKWNFPITLDAITGSMQTFPIFFIEFGNGPQQSAIRQKSGGETMNGSNWNIDNDGIGSVLNEIEQEKINGTWAKKLHFVPPSTDRMEIYFQIANPEFSKLITRSSHLKSYENYPNRSTPTPCEVYGNDCEEIREILKRIEDLESCHKNRPALPDDAFKLPPWKNPPAASPFNSFKKRSESLRCHGGDVPCNKESLHKEYIEARKTCRLVPEEGNRRKKRQYLPEENNTKWTEFPIKIGFREKDLPKPYTAWKTAIKEAFNLIMKETCVRFKIIGKQPHSSSLMGGWQELKLGIRNPLCQQLNKSVAAAHELLHALGLWHKFERSDARNFTIIRGDNGGLQFDAIGTPAFAEIGTPGLARYLCGVKWLNFTGAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4Y3</accession>
    <name>A0A914I4Y3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4Y3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g735.t1">
        <property type="protein sequence ID" value="Gr19_v10_g735.t1"/>
        <property type="gene ID" value="Gr19_v10_g735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g735.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26345" checksum="7A712B3BF33F457C" modified="2023-02-22" version="1">MGPKKMVQPTGWTKQQWRTTANVGRSNRTSNQSSTGTITRTVPRWTICSQRRAQLEMDLYNKCRPTAAHFPVQKRRRLPCPTAKQRHSHLRHHCLCPPPARPFVAKAVQKFSGTGTRRNLDKRPCLAVLGLLGALSGGKRKRRHRTIFTEEQLNMLEEAFRGTQYPDVSVREGMADKCNLCEERVEVWFKNRRAKLRKRNREVQQPTSTNPNSAPAGSHCVIKPKNNSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4Z4</accession>
    <name>A0A914I4Z4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DOCKER domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4Z4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7358.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7358.t1"/>
        <property type="gene ID" value="Gr19_v10_g7358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036858008" evidence="4">
        <location>
            <begin position="30"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="5">
        <location>
            <begin position="143"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="565"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7358.t1"/>
        </source>
    </evidence>
    <sequence length="736" mass="83328" checksum="685A48CF8B0DEA4E" modified="2023-02-22" version="1">MAFVGSDLCEFAVLIFVDMLATELRGGSADDVVVVRRRKKDYDELLEQPQKLFSDVFISRLDPLLDSSLSDALFAIFRKAFSRTFQRHCLEQIVAKQFEFSAFVQTVDRLLELFTAYRSVQHGTGDEMAEMGMFCTAQLVDFYQSIEQHELYVLYLYKLYTLHRTVGNWVEAGLTLKRHADLLRWSASHRPDSYLCGTARNNEGGEFGTELELKEYIYKEMAELFTRGEHWELAIETNRELANIYETTTFDYAKLADLLTRNAALYEKVTKTLRMESHYFMIAFYGKGCPSHLANHKFVARGRPLEQWGCFKQRLMANFSDFKFVDTVDNCEETYRELDDFASFTDAIQGASWYYKHHRVQRFELVRRAFRADTKWTQLEDNETTRLWLHKRIIQIQRPLPDLLSLGPVVSELELDPLNPAEVAIEKMREANDKLAETAAMVGEGFAQSLVNLAGMIRGVVQADVGGGIRNYQAFFSEESRAVCTEDERHAVGTLKQLILEQTALLEYALFIHSQSDRAQANAMFHNSLAGSFMEHRQRVEHWLGPVKSVLPEKTSIYVLEPSSDEAPHHFEGSRRQVAADQSPTPPTQKAPQKIARIASMHENGISNNNHQQQVRPTSMGSASGGSSSSSTNVFKNSNLGAALIKTTIQAKAKLKQKASRKGSAAVAIRANSIATPATTQQQLSAGHEFLSAISQARQSDTSMDTFLLEMEPPLPPRLSKAHSDQIVTNLRIRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5E5</accession>
    <name>A0A914I5E5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5E5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g768.t1">
        <property type="protein sequence ID" value="Gr19_v10_g768.t1"/>
        <property type="gene ID" value="Gr19_v10_g768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47408:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47408">
        <property type="entry name" value="PROTEIN CBG01304-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g768.t1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52223" checksum="A9FA1CD8479D9E0A" modified="2023-02-22" version="1">MFIDEVFSYYVLASICVVVVFFSFASIRPENAKRVRRPSASSPVHFHIIKLNIHSTDRPSVRHQTSSNWHLTMSIQRHFINKLSSSSPQGMMWCCKTVLPLRHCANVAAAQIQNAQHALLPFLHKTAADNEGDVDPVVQHPPSVPKWKQAGLRIERNCSDQIFQTIAKEVVDKFGWDNSAYDYGLWNKVFGSNFSMFFALDQNRQPMGCISMALYPQVAHWSMYYVKERYRGHQLGHALTNRSMELAGDRPIFCYGVADMWFKYAEDYGLNHLLDWRLWEMLANCADVRPERLDDDSSVELKDWREVSFDKLLSFDRLQTVGIDRTAYLQGALRLPQSVAKVAVCKATKEVVGTCQARQLLNRRVGISLFYADRPSIASALLRDVLLHFAGPDPSTKFDTLLYKTPSNNTESVRLFRQLIQNGPVERQVLTPQFSRYALPFPGQRIFSIGDEHVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I661</accession>
    <name>A0A914I661_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I661"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6983.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6983.t1"/>
        <property type="gene ID" value="Gr19_v10_g6983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6983.t1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47067" checksum="52F4C066C8BAB0BA" modified="2023-02-22" version="1">MPIFCIDQDIRLSRVEVTAGDSFSNAINNMPRLTEQRESAVHTFDQLMARRENRFRAIRRQKQRKKLAKQIDQKPKNGAYGTAGRVLLSNERGLERSSVIVVPVDQPKVLTAETFVTGRSRRIHGQVERKNPSGDVPFIDRSTAVKVKEVPMAKRFQIVTGTHTTNALSRSDHTNTVVDEPIARLPADSWKLPPALLAGRLRRFNKADIVRGFRQRALRAGVELDGDKLRTLMRQIDIMRRDDHQRQHLDRRTDTATVPSMSFLIDDDSYHRTVDIDGEKPKSNMPLVVKPNLRTKFPKNRESAKPIKADESDMDLLHPTASGIAELKQYRKFSETQHVHTHQHQHPPLPSHASPSQPLPPPQPTTTNHVPIQSSTVGVPPALTLPSLQRPLSHAQKAAPTVPTGKLSSYTNRFLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6G5</accession>
    <name>A0A914I6G5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
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            <taxon>Heteroderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="Gr19_v10_g7754"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
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    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
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            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="134"/>
            <end position="153"/>
        </location>
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            <end position="186"/>
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            <begin position="219"/>
            <end position="240"/>
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            <begin position="252"/>
            <end position="273"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7754.t1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45774" checksum="AA5172E1B370F6D3" modified="2023-02-22" version="1">MYWNFDKKHKILGVLCLIYGIWHFGTNWTTTLVSFLQWDTIEVLSIVDLSYIQAFGSLCNAFGSLAIGQMTDSIGPKFMFVFSTVLTSLYFVGLGFCRTWYSFFFLQLLRVGYQLDSTAEMYLATVTTERERTGSLMILTIPQAFSMFFAPILGSKIAIYTTLRLSQIINGCVMAALLIPVILFFLPTTHSVPRLATARLRPQDYWPMATKNVALREGLVLRGLLIVAYVCYELIARNFVLRSYMHATSDNAEVMVTMGVSLVITQFIILPFLQRHVSPKTLLQLACVAQMCAYAGITLTNSLYQYLFITAIHTGAYAIAYAESSTQITSAVQPSDLGKATGLASMVQWSAHFVVPLYTSHLVNYWHYTYAFYTSTLIMLITIGYITVYAKQTNARLRTLLPSLITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I713</accession>
    <name>A0A914I713_GLORO</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Globodera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I713"/>
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        <property type="protein sequence ID" value="Gr19_v10_g7345.t2"/>
        <property type="gene ID" value="Gr19_v10_g7345"/>
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    </dbReference>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037686689" evidence="3">
        <location>
            <begin position="22"/>
            <end position="760"/>
        </location>
    </feature>
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        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
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        <location>
            <begin position="704"/>
            <end position="760"/>
        </location>
    </feature>
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        <location>
            <begin position="415"/>
            <end position="460"/>
        </location>
    </feature>
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        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Coils"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7345.t2"/>
        </source>
    </evidence>
    <sequence length="760" mass="81822" checksum="09D38D084B6E1F5D" modified="2023-02-22" version="1">MILSPLISFCCSLIMLRIIKAKEPKQNDVTAANGTNFAQQSPRLRLADERPSFTNELQNTQLFRSARNSLRFRAASMPSNEDRTQDEVVRLKNVAKEVEEKLGLSPPRLNSNRQGPTLIGPKRGELIPAIESPGLSLRRLIAVGDGAGGLPRTRPTNPLFAATLLRQQQRESAQTAKFGINPVVGSNFIGKQQQLSEQQQRMVQQQQFQTLFQQLATIQQQRQLQQLLLNNQWQNAAERNERLGASRASSTFSGNVENLAPPGFFGAGSGQTSVALPGKLALTGIRSVGQPPAATASFLGGIQPIQPPPIAPPLQSSSTDLADLTALLQKMSLNNPTNPSSSSTVLGPIAAVLPNAASPQVTPQQERPVVVKLVTAGSEQQQQNTNNNNNAVALQQIVLQEQQRFVELLEREQYREQLVQNNRKELQAVQDQQQRILELLDAFEREKEQLEDNSRAIRRTALERNKAIAADSATSAPTQQQSSADTNLLKGLLQAFSNIITPQGTPSGTASSSTSGQPLPNIGPNLGGQVSQFLNQLLQQPSTTVDQSQLLVKIPQQQQQQKQAQAVQQPAVQYVSLYDPRVGQQQQFDAASLLVGGDGTVSSGLVQPQQQVGAVFQPQQQVGAVPQLPQQVGAVPQLPQQVAAVSQQQVGAVPQQQVGVVPLLPQQVGAVPPSGWLPVGDVLSGGNNGQQQLLANGIVQRAQQRQRQDVQQPTADGTAANGQTVDEDNVEEVGEEEKEAGLEDGRWTASADGGGGLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I771</accession>
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        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="Gr19_v10_g7544"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="F-box domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7544.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="46343" checksum="0F81D76F1AC9E418" modified="2023-02-22" version="1">MELNSTLEALHEEETVERLNESAEFRGDLDSSFGSDLHSVSFQEISSVLRAKPDINVFYRTPCSGANRFSRRSSSAHALTDRFSHALPDSLLLRIFFYLNKHDIVNVMLVCRRFGQIAKDKTLWEFMNLAGRLIDEESIHSLFNRQLKVLRLASAEIKTPSLFPWFDMQHTGSAQLTHLDLSQAKFETSDTLVRLLSRCKSLQALSLESCDLLDDECCRVIANNSALKYLDLVYAKRLSVAGIGTILCACQKLVELNLSWAEVEDEAMLTICQRMPSGIRKLNLSGFRQLPSLNDENIGRLCAVCPQLEELDLSDNALLTEHCLESICDGLKRLRRLTLSRCYGIEPMAFLQLGTLDELNIFGCITNDGVCLLRNRLAPTQVNASPYSTVAKPTVGDSITSIWRHRTRDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7E5</accession>
    <name>A0A914I7E5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7E5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7602.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7602.t1"/>
        <property type="gene ID" value="Gr19_v10_g7602"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="476"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7602.t1"/>
        </source>
    </evidence>
    <sequence length="836" mass="95921" checksum="4792FB9094FF67B8" modified="2023-02-22" version="1">MEIPASSEKFLIDCSMVEIGLYKYSPTKQIELTHEFITLPLDNGKETLLLSLSFKHITKVEFLDNSEGDGAGLVLFVNDFMARKIQNYIDRGGTGFTEFTLDSYTSQSHKSKRIIVMDIQNKEPEFFQRAHAILHAAAAYHRSYVIQQMNKTNKLIDLPVTYIDVVSSCQWQTLMKLMANVANAKFMHRTIKVPMEFTVIDQNKNGISPSRMPVFPTLLDSSQAQHLLATECQQQRVVVGQIYQQQPTCHLPTYTVVTVPHSQPTTPLTVSASQATVMTVPNPPQFLAVETVRDPFISRLPPAMLAVKTSPQPRAIQLPLSLIEKEEPTDMLFQLDHEQIQRHNQQQKHHLNDTATFGETTVAQYLAMESSTGVKLIPRPIKVPMQFGNNNRNSRSALPLLSIQTPPSTSQEQQQQLSPKSQQRTVLRSAGTAKVAKREREVHLIDDEESELEANPVDKRSNDTLFSFPPTGRDSCSVHYADLKYLSRNFMLNDTIIDFYLKYIQHCLVPQERRAKIFIFNSFFFGRLTQPPPGGKPSNAVTLATKIRRVTSNFQKVKNWTKKVNLFDMDYVVVPINEDIHWYLAIIVNIRHCICTQQVNEHLSTDPNMTKSDTKYHPPMSHLIVLNSLIDPAEDKHLAVRDQLGEYLHLEYADKHCQDNATFFNKQLMDVVVPTMLPQQKNFIDCGLFLLHFAQLFFTNPPRIVSRHSSFRRWYPNFEIKHKRDELRCVIMQLASHVKASDFVQRPTPKRKSRNGGRRPQVDKMQSIIDGMALMGRTRRYSDSELDGIMKDEYFPNREKPLVLQPPTIAEMSRFKQLRRVRQEIFASTVRQGQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7T9</accession>
    <name>A0A914I7T9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I7T9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8295.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8295.t1"/>
        <property type="gene ID" value="Gr19_v10_g8295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8295.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24689" checksum="C0C8652B85E77BCA" modified="2023-02-22" version="1">MSGPTPTTSMHSDLDLAPLAPKSIQHGRFTYTQARQCLSDPLIEEVTEQVHVTLGWQHAGHVETAVRRLMGEAVGHYRPKIDAVPIAIGAIKFREPIFILEDHNCVHVDVDVRMIVLKVNPGDGEDVPDGHLEITGTARKVYQDKLISGTAYGCLGLVCSPIIPGVKPGDVFRARFLGVQFLKNLCQIRAAPLTDFRYRGARTPSPCIVRREFSWKKNNSAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I848</accession>
    <name>A0A914I848_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Insulin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I848"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8170.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8170.t1"/>
        <property type="gene ID" value="Gr19_v10_g8170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036964143" evidence="2">
        <location>
            <begin position="25"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8170.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21587" checksum="53D2763ACB538A41" modified="2023-02-22" version="1">MPLLLFRMLFILPALLLVLRPSTDHSSSSSSSSSTRDRSTLVLCANALPISIQDGTAEQKSVLGERIENDGQAKDLSEQKTTEDFSNFGRLKLCPPGGRSFFEAFELACPMKRRRRKRHTMFGFGRAPTMAFGKEMAARYGNIGGSAGEADKGDGAVQQNWNVYRPANITEIMQICCSKGCEFADLLPHCGPFSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8A4</accession>
    <name>A0A914I8A4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8A4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8212.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8212.t1"/>
        <property type="gene ID" value="Gr19_v10_g8212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22432">
        <property type="entry name" value="KH-I_HNRNPK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="291"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8212.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="38711" checksum="00514146AE8EEBE8" modified="2023-02-22" version="1">MNFSAFDAMKRQFNQDSNNGMQMYGGGGQMNGGSKRFRGPHDAGEAYQDALAAGKFELRLFIPSRSAGAVIGRGGEFIKSLRSKYDANINVPDRSTPERVLTIVCSVESVEDCFTEILAKLSEGEKASRGEIDIKVLVHQSHAGAIIGRSGSKIKEFREHTQCRFKVFQECCPVSSDRVCLITGDPSKLPGAVKMLVEFVKDIPFKGPHQPYDPHNYNPHMCHAYGGFEGPTMGGPPPPMLPPHFDYQPQHHGPPSAPQPGVGYAGFGPGGPPPHPGGPPPMGYTGPGGEQVTTTQVTIPSESGARIEIDTQSDVFGTDERIITITGSPLQIQMAQFLLQQSVRQSESGRRYLSERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8Q3</accession>
    <name>A0A914I8Q3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8Q3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8529.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8529.t2"/>
        <property type="gene ID" value="Gr19_v10_g8529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8529.t2"/>
        </source>
    </evidence>
    <sequence length="251" mass="28657" checksum="3727C039D20A72B0" modified="2023-02-22" version="1">MGTLPQCLAWSALYAELSFKLGNLCRLSYLVFDSLFGLVVLGLAMARWTDIFVRFWTAVHLYIKQLETLITWLTNNPAGLKLNDALNTFLSNFFFYHIHIWRTYVTFFEHSWTKWLLIASGALGLSVLVAFLSDFLRVLTVHIFCFHIYTQKLAKVCWAAFLGVSRAFRSKKWNPLRERVDSVKLDSRQLFITTLAMIILLFLMPTICVYFGVFSTVSVGMCTLAVRRRRLPIVEACGANDSSDIGAQLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I926</accession>
    <name>A0A914I926_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial inner membrane protease subunit 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I926"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8407.t4">
        <property type="protein sequence ID" value="Gr19_v10_g8407.t4"/>
        <property type="gene ID" value="Gr19_v10_g8407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037034656" evidence="6">
        <location>
            <begin position="21"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8407.t4"/>
        </source>
    </evidence>
    <sequence length="435" mass="49764" checksum="BCA4E47A99757ED8" modified="2023-02-22" version="1">MILKVIGSVVFGACIAQVFGKRVGAIIICRGDSMLPNFHNGDILWARVWKPRHGLYPGDVVCLVNPQNANEYVLKRVSVINGRGRPASPLTGRIEVRGDNAAVSVDSRDYGPVPAGLVHYRVSARLFPRNLPHFITLFRPILPISMFAFINFDKFRMWSAIGAVGVAVVYGFDHYLGRFAICTKDNLRYDLKRWDFLWCGRWNAHTGEVLKPGTLVYSLHPMPSDIYAFRKYGYFFGEVNAVKTTVCVCCRNRMASKVLLTLPKSDAEDEQSAWVQSGMEISICADVWLEPFAFIDPFELGHLMALISDRFDRLVDAHFKSRKWTDSSQSFCQCFCAGQFHHPSAFIFFGTEPFELTNNWTGERLTLRRLNEYDWLLVRCPIVREEAEWAKWEKEANEWHEDRQWNWNCIDINFSDRHIGDGMADAMAGPSEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB48</accession>
    <name>A0A914IB48_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB48"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8326.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8326.t1"/>
        <property type="gene ID" value="Gr19_v10_g8326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8326.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11239" checksum="B0B952DD3686A342" modified="2023-02-22" version="1">MSQAQLEQAFHKFRKEYQKPSQLKVLSIINHWRNQTSCRCPAANRFPSKTLTQSPPQQQHTHQQPSQQQLDAGHSADGEVTATSSPLSPPPSIACSNSSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBU4</accession>
    <name>A0A914IBU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ACB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IBU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8494.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8494.t1"/>
        <property type="gene ID" value="Gr19_v10_g8494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="48"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8494.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31620" checksum="9BD9B863D5FDF234" modified="2023-02-22" version="1">MLFRHSTVNLLANLRQCRFVRLPNAGIISQPLATSDLSTMRHYSSHTTSEQFAKAVKDLKKLKEEPPNDIKLKLYGLYKQATEGDVHGDRPKMFDFVARAKFDAWQAVKGSPEGLAEFKYVQFVNLLLEEAGIDPDSSDAAPSSKESVANVAESDGLRLAKEGKVFRIELNRPDKFNAITWEMYEGLISALGEANADRETSVTLMTGVGAYYCAGNDLSNFFRGVKTGDDLRAMADRGQDVLQRYVRSFIEHDKPLIGLINGPAIGISVTVLALFDLVIASDKVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID41</accession>
    <name>A0A914ID41_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID41"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g88.t1">
        <property type="protein sequence ID" value="Gr19_v10_g88.t1"/>
        <property type="gene ID" value="Gr19_v10_g88"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037479023" evidence="2">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g88.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16837" checksum="47620D311FB162B0" modified="2023-02-22" version="1">MWVVVVVVVSLTRNTTVLAYFCEEQQQQSGAERQTEIDPSLSLSPRLLLFTIIIITPKNPVQSRQQSSPTTTKARRRRRGETTSGRGEGAAVSLTHKVKNGHGAAAAAAGDGAEPTHGQRHRQTCTHTERVLCTDSSGSKTDEKQRERESAGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDE9</accession>
    <name>A0A914IDE9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IDE9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9821.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9821.t1"/>
        <property type="gene ID" value="Gr19_v10_g9821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="588"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9821.t1"/>
        </source>
    </evidence>
    <sequence length="629" mass="68465" checksum="E5FC1580A5076531" modified="2023-02-22" version="1">MPLRNSPVGQRPNAADAAANSIFHLSQIWLTLASFEQLQEMLSWLLNGPLSLLFVLSGIVLNALCVVVFLRFRLGGGTTPIIHYYLISLAGWHSALLCNAFLLYGLPTLLWGSVVSSGPYVHLYPPTYTLANATHTGTVWIILALTLDRYLALCMPFKHRIFSKRSRVKRLVVGLSVGALFFCLPRFFEVRTAVECYDTLPPVATVTATVAAAQQQQAATVLVVTTVPLSNATVIVEGPPPQQMATVSSRCETFVQRTGLPENQLYRTIYHILLGSAFVTILPGVLTFVLTLRISITLGEARRQRKRLSHCCNHLLLDSAGGGGSTTTRTTTISTERESLPENCVSGGEKQQQQYHHRMVLLSASAVAGGRKPSLKRKEHRANVMLVVIIVKFLISDILPTVLDVFETFIGNEVFMASPLATLWVDFSNFLLVINCSTNFWVFLLYVRGFRQRCVHLIANSFRCSPQSPRQHDEASGFGGSCIASLRPSTPHFSANGFPIVAHGHRARGSAGGGEYAELGKAALNNVVLSQQNANSTPLRNGLPNLNGRITTTHRQEVGMEALIRPKRASSLAISAQQRSPLSFAIAVQRPSSSSSPRSTPTAASAANRMSTGQPPPPHRKKGSLAAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDW9</accession>
    <name>A0A914IDW9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TBC1 domain family member 2B</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g9948.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9948.t1"/>
        <property type="gene ID" value="Gr19_v10_g9948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="614"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1415"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1417"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9948.t1"/>
        </source>
    </evidence>
    <sequence length="1504" mass="169041" checksum="F522DE235ACAF03D" modified="2023-02-22" version="1">MNVSLSPGGLRVLSPSYSDCSPSDSSVGVPLLASSLGAIRTGSSSSLPYHSSNTAADRQPRAKEECFSLEGYLSMKSLSGALASLLQSRKRLYFGLEEMDNHLVYYRSKMDFDTRNDCLGHISMEGAFCSLVEGNVRAFLLHTNNGKKYQLEADNDRAADCWLNVLRQRRENASRVNGEREGLLVALNGLGRHRRRSRFTGDSDSEVESDHVELQRQLARSHLHPKRRNLPPLRLDLLNGSALIGLENASASTPPTPKSLPLFRQHNNEKMLLRKASILGKTAPAPQSDGAGCFMCGARTATKEWVLNTWLKGQKHNAADGGKERCRLGTTSSEETSHEGAWPVTENGHGATIDAGSPESMSSNRPSTSPPATEQLAVPSSPSSVTCESAGAYHVPDELMILRELSNRQKMQIVELNEELERMKAVAGRVAEGTPIEHSFAAQNRFLNSELLRINERKLESDRQTDEYKRQIVKLEAEMEDFKKEYVHLLQSCVRIPIRDNSSCDVVQIKLFGGDEHEKRVKKLLEKARELNPALPTFESVVRSSSFHVDEYGFRHSFDETPLAVHFIATQLHQHYQSRSSDHAQLKAKWRVLLREQPERIKRSRDVRLLCRRGIPRSLRPRVWRLLINQQFARHASGKALQLRASEAGELGLAENDARQRALHVRLLQGRHPSAGMNFLVATALLFMGPEDAFWFLVAITERYFDSSYFDQSLTGAQADQEVLKEIVEQKFPRLAQHLDECEIDLTTVTLNWFIALFFDAIPFQTMLHLWDCFLYEGPKVLFRFTIALLGFHEEELLAHSDTISVIKVLKAAVRLTFDVNGLIKFAFEELSPFPGKAYLRQRQLLYLRVLQEQLFKRQKLRQLLNITNSTALSDQLCNLPIEVVVFSQFVPGRGYLHEETATLNTLDLEFDCRLISMVVFQPEMAFVSLLSGYIVALHLNDSGEAEILWELKLNDVALKLVNCSQRLYSCLANGTLAVLENAFERMPSALDLYHIPIAAAPITDALLDKDHLYLAVACKIVVLNQSTLSTVASVYVASASVGSQVPMFEKICNLAPSPFGIWLLTAHSSLIQLWRDGQCEMLFDIRYDHSHRKPSFNENDEKMEQVELCSILFHSDELWVGTVDGYLMLYRVLAEPPSNFKPTKFRPPEGRFQPGKRLSAAHGLAQPVPKSKLQTYYIPTENETKAEEHSSSMELETERQMMSAEGVGGVRRISVVIDPLSRKYSVNVFHLSVDSAHNGTYSTGNSTNSAPIPPFRAVSNSFPPKSYRMSSSPLSKPSDRQKRMRALSFHNRNCKFSNLSLDLENDEIFETCSDEGDKKLEEGRTIISTDPKEEEKRRRFPSRLVRLRSWRKLSSMPNSIDNEPSEMVGEIQITAEESGADGYGGGAVEGVRIKRKDLNFEEPLLLAVKEGDDINRSLGTSPSSRRPSLSSNMDPDEPNELETTEINSSLGMTLQMKLKVSDKPLRCISLGHFQGQDVVITGAGEYGDDEAFLRWRRDPKNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDY9</accession>
    <name>A0A914IDY9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IDY9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9008.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9008.t1"/>
        <property type="gene ID" value="Gr19_v10_g9008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9008.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15390" checksum="EE8FB3DE936741BE" modified="2023-02-22" version="1">MVDSPTTGMNYIGESTNGESNHRRVTSASLTIAELTRRRVDPSASRQSASRRRRVELAEIGERGSGDVKGATIELLNNVRYDLVVNFTSNAWRNVHDRTEDLLEEWTRLKLFEENTFAKGNELYMMEQIYDFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEU7</accession>
    <name>A0A914IEU7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9243.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9243.t1"/>
        <property type="gene ID" value="Gr19_v10_g9243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9243.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33233" checksum="C4D86E7426EE75FA" modified="2023-02-22" version="1">MPEILVPDSFPRTPTLAPDPNTLCFALRRKFFYPKKMHFIDKIFPANFGCLVFLQSHAKLFNNAKSNIENIESPKSSSSTKGTTLFEIPNDLLIHQIFAQLNVQDICRLKRVCRRLNTICADNSQFLPRQNVPLVMVRCGQWRDVLKGRRINHSSDTLTTIEFTILPFRGGNSAVFKRKQSHLHITYRQLIEHFEIDFMLIDVQLLNGDTIERLQLERMAAKHLLIDFSLCSCWLIGHHFCKILEQLGSNEFARSIHIVFDRRKEFVRKMVEDVMDKRISITFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFD2</accession>
    <name>A0A914IFD2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFD2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9375.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9375.t1"/>
        <property type="gene ID" value="Gr19_v10_g9375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037089866" evidence="3">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9375.t1"/>
        </source>
    </evidence>
    <sequence length="445" mass="52015" checksum="0FDB68E9A0DC4ED4" modified="2023-02-22" version="1">MQLYLSILFLYLVIHKVTATSPSTSERDQHIKTIFAIDMNRRIDGFKTSTIEERMKEMERIEQELSEQLDRAIHLTKILMKLDETEKQISDKFYEKVSISSLSSTNVAMPNRNANINPFRIPNRQPTTTTLSSDQENKREGKSRANTAHESGANHQGQDWTILKVPKQRPNRIDRSTEKAEALSEWKLLMESIVLNLGRLPKYANWTRELVRNEFNMLAEWYQQTMIMNNKMKLMMDQQQSTMIVNHQRIRVIMNQKMLKLVMNRASIRVKMNQKKLNPSIRVTLIQKKLNPSIRVSMNQKKLNPSIRVPMNQKKLNPSIRVTLIQKKLNPSIRVPMNQKKLNPSIRVTLNQKKPNPSIRVSINQKKLNPSIRVSMNPSIRVTMNQKKLNPLIKVTMNQKKLNPSIRVPMNQLQQLIRKKMLQLKMVQRRLPLLANLKRLTVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFY6</accession>
    <name>A0A914IFY6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IFY6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9550.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9550.t2"/>
        <property type="gene ID" value="Gr19_v10_g9550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9550.t2"/>
        </source>
    </evidence>
    <sequence length="668" mass="74375" checksum="58C4D03CC9AD175C" modified="2023-02-22" version="1">MFMTSLWPFMKILDKTVAESFYGLVLALYSISQIITSPLLGYWSNRIERLKPPLIFCNLMMLLGNILYLFVELFPTHHYRYALCTSRFMAGVGWAQLGLLKSYVAAASLVADRSRATAFITGGFALGVILGPALQTLFTLVNYPGFPVCFVNRYCINISMFTVPAIFASLVNVALMILLMVRFRESHVGIIERVNMVNETLQIKKSTKLPPYDRCAVAVCFALRFTQFFVFTIIETIGTSFAMLMFNWSPIEVVFYDSMAHAVRGVVALLVYVAYIIFDLGKIVNDRIVCLLSLVALLFFYLITHTWPFLPEHVRLMNSSFVGNSSANSGGCNLNKYAWCAGLPRVNPWLYYGAIVLLIGPAFPNINVAMNTLFSRIIGPRIQSTQQGLLEMHGAIGRLIGPLLISFFYLSYGVPIFCRQPPTTVGGGPNYQFPDQQRLFVLISGTFRLIIEILGLPMNSFLAFITLKNKELWTTSGILLAIVALCDAIVSSSPFILFYFAITGNIACILSKCMPNFVGPYGNVVGKISLGFSVMIIACYLLLFGFIKFVYKATHKNSQETAQKILKSLTVIVMIYLAGWVATQIIKYNQQFFLPPNLLSQVLSTTSGAIIALTEIITAPVLYLTSLNYQASIKVQPMQNVHISRHPPTFALAKKSNNNFNLCLASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPW5</accession>
    <name>A0A914GPW5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GPW5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10332.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10332.t1"/>
        <property type="gene ID" value="Gr19_v10_g10332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10332.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14687" checksum="43A07FAC7F012381" modified="2023-02-22" version="1">MASHTAGIQQLLAAEKRAAEKINDARKRKAQRLKQAKQEAQAEIEQYRQEREQRFREFEQNYLGTRDDIEQQIKRETEELLEAMNRNVAGNKQQVIVRLLQLVCDINPELHTNLQLQMKLFGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPZ7</accession>
    <name>A0A914GPZ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPZ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10097.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10097.t1"/>
        <property type="gene ID" value="Gr19_v10_g10097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011:SF6">
        <property type="entry name" value="HIGH ZINC ACTIVATED NUCLEAR RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10097.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24193" checksum="562D3F091B8E61C8" modified="2023-02-22" version="1">MFGAGDDRLLMPDGGHVRLSELQKFYENNSLVRGDPSQVAKVFENAMSYLVKTVVAHMRLIKLTEMELVALFGMFIWSDSEAISEESLQTALQVRNDIIVDLHMHYRTLGLAEAEVTLKTANVFLLIPKLHNSMRFLREDFSIASIFGMVANCNGPSGREDEYGGEQQQAGPSVKQQHQQQAEERQGNGEESTSAQQQDSSGGEDTSSTVDVGKHEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRP2</accession>
    <name>A0A914GRP2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRP2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10679.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10679.t1"/>
        <property type="gene ID" value="Gr19_v10_g10679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10679.t1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42683" checksum="61EA71FF4B63FF60" modified="2023-02-22" version="1">MPNSLNRLFRRLRESHDDAKKHKKSSVTTHPPMTGIVSGCCSRRTSSTLLHPTKESQNRKTSAANNCRSGEPILPEALLFRILDDVESPFELFSLRRANKNCADYVRSRIGRVSEMDLRRVSFDELSSSSVSSSGTSAQSETTVILQGELWHVHPSGCKVLCRMSPVDEQQPINGDSNSDVADANIQLRLEVLVDEQWTSREIAILCSLVNEFRQAVKRISVDAPIFELIVANLAAVDLDRWFAYQCFVKAVDDGQMSATLNKLAAQLQQQQNDPLDAIVNDNELYWPNAKTILVRTTERESVHLARVLFYGVRANLLIDRRRLDRLALLVCVADAAIVHVSMSERPKELVRNLYHFRCWAGSPGFDERFSQQWRCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSL9</accession>
    <name>A0A914GSL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the globin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11.t1"/>
        <property type="gene ID" value="Gr19_v10_g11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053341">
        <property type="entry name" value="Oxidative_stress_globin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47768:SF1">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47768">
        <property type="entry name" value="GLOBIN RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="2">
        <location>
            <begin position="99"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30439" checksum="0782513933F66E65" modified="2023-02-22" version="1">MEQQQADNHYVTVSGQICCGLWHCSALMRTIRSLFHAGGGVPPNAVAQKVGQQKNGGAVENVVKTSTHQQPIEMVKTTDPPSAEGSLDGWSEAQVLKWEPNDYEKELVKRTWSDDFDFLYELGAAIYDYIFEHNPQTKQLFPKIHRHGDQWRQSADFRSQALKFVQTLAYAAKNLCHMDECLQPLLFAIGERHVQYASRGFRPEHWNIVLDAMEQALTGHIRSLNDFTAQQRLDATRTWRRLAHFIIANMKKGYLAREAAEAMASEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GT41</accession>
    <name>A0A914GT41_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GT41"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10148.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10148.t1"/>
        <property type="gene ID" value="Gr19_v10_g10148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10148.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33229" checksum="12681481B16B2B14" modified="2023-02-22" version="1">MSDNASELEQQQQMEKIFICADVWHGVFAFLDPFELGLKMALISDRLDVLVDVHFKSREWSLGSMEIRRADDGNGAQIDNERSDEGLPIPQEPLPGKVIGFEEIEISYVDQTVIEFLQRIGRLFDSSGTDVDIYTDGDQSRSWEIIWQKIWPLISGTVSRREDGRPKMFHFDFYSTEIEGLKGSFVNASEPLNFIISFDDDDDDVVPFELKNALTGERLTLRRLDEDNWLLVRCPLWREEDKWTNWEKEAIELNWDNQWNRIIINFDDKDIGDGMVEAKAGPSEPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTP6</accession>
    <name>A0A914GTP6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAT2 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g11254.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11254.t2"/>
        <property type="gene ID" value="Gr19_v10_g11254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033184">
        <property type="entry name" value="PRRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038">
        <property type="entry name" value="BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038:SF0">
        <property type="entry name" value="LP18708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11254.t2"/>
        </source>
    </evidence>
    <sequence length="1514" mass="166185" checksum="5A4CF619E8D13996" modified="2023-02-22" version="1">MFDFVDFEKSYNEKTLKKVNELGVNELAGNDFKKVSYLFFTHTINIKSKLEIRSFIPKQNLNKYLSYLGRNTATAGIGGGGKGSEGKHGILALGSAKNIVRRMPPPATLPSLKAEHGKDPNIAIVPQGGTGWTKPTTPTGSTPTNAAILDPIRNQSVEELTSKTDGSTSYSRISSSAHSTTAGHDLRPNWARPVGNSSGGSGVRAITNVLEPQPLLSQSVQSELSLQGLKQSQQNSREQQKSDRDFPTLAAAASNKFQAPSEKPKKQEETEFVFPFVPQPQPVGYIGASGPKSSVERKLPQRYFGGSIAQKATSNLTQKYDVLQRLARISVDKEQSEKSPSLESQPNTNVSINEPQPLLSQSVQSELSLQGLKQSQQNSREQQKSDRDFPTLAAVASNKLQAPSEKPKKQEETEFVFPFVPQPQPVGYTDASAPNSGCGRKLLQRYYGGPIAQKATSNSTQKYDVLQRTTRIFVDKQPEKNSSALESQPNTNVSINEPQPLLSQSVQSELSLQGLKQSQQNSREQQKSDRDFPTLAAVASNKLQAPSEKPKKQEETEFVFPFVPQPQPVGYTDASAPNSGCGRKLLQRYYGGPIAQKATSNSTQKYDVLQRTTRIFVDKQPEKNSSALESQPNTNVSINDTNTGIYNHWNPPSLCGASESHWDDPLPVPMSSERLAKDRRKKDQFGVRSTIGIRREFVNSRNKRGRSSHMNIGSRGERERNFIRGGSKTPNSSANVQLKQQESSQLCNDSHGLGDSFSNIGEFHAEDYNSFAEEQKRSKISAVLNNKKKGSQRMRGEKSLRGGNRNGGLQLSYKDEKECRTVVKGGCSSSNTEETQGTKKSIVSRQERAKISPRAQIIAGQKNAKPASHTYQNNVGSGKSNNVLKNANRARSSSTRVGDVVSGARLHRKGNATHPQKQRSVPKKDGLAGVDINAASVVVIDVGNSEEEIHQFESNRRRNIGEEEGEDHAFEEVLSKRSRKQRMAQKAEDEKRQRVYLEKRETEKKQKSSGRLNQRRSKSEIPEVSIAPPPMIPSLASIDTSSVMARERVHKRRQNTTSKKQQETPFGNENGCEPIEKKQDSAHEHQLLLQDSQKFIPSREGASIDPPAMLLLMDKLSINTTGDDSLWHLPSQKAPPHSPLDSGNDAFHDVNDSQTPDIIPSPIARPTPKDRQRSENNDVVNDCELKAHEKIVHQLTGGTHSMDHQNCIEHAQLQRQLDKVKDFWSYSGEASYRNDVLADHKGKTEDASRNERDGLADATIKSKLMAERGIVQSPLATANGGNCNFDGSILLNQTMDNTGSLTNVVGTHAVPTYFPLPLCHAHTDVSSFHVHRLPPNFTHTSSLSSAQLISSEQSPVASINLARPIPTPTHLPPPAAIPTHLPPPSLSVTHPNLNPATHHFVGPLYGRLPPQLHHSQRAGIIDFSMFPPPPALNRNVRKANVFGSDRIIQAPLHSTFGPLQSVNAASGAMIGGQHQSSAIPFGVFPSPAPPHHHRSSQFTIAPPQIGVYGPPPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUC5</accession>
    <name>A0A914GUC5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUC5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11293.t5">
        <property type="protein sequence ID" value="Gr19_v10_g11293.t5"/>
        <property type="gene ID" value="Gr19_v10_g11293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031354">
        <property type="entry name" value="BRD4_CDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17105">
        <property type="entry name" value="BRD4_CDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="107"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="377"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="6">
        <location>
            <begin position="720"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="794"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="641"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="703"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="824"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11293.t5"/>
        </source>
    </evidence>
    <sequence length="1257" mass="140073" checksum="AD03AC04C1622A92" modified="2023-02-22" version="1">MDQRKNGHQKDLEPGTSFDDEQFTKSNEADASHLSHHDAHSDTMDIGEGLPIESMNENDCPTKGWETPPQESVNGMVQPRVVPPVGKPTRWTNQLDFILKDVLKQAKNHKHAWPFVRPVDSIKLNIPDYHKVIKRPMDLGTIERRLKNMYYYSASECIKDIMTVFNDCYLFNPPHFGDFEQIFANCYKFNQCEDDVTLMCKNVENLYRDRLKKFPDKEVEIPFPSQKKAGKGSAKRNIRASSTTTKGTTVANSPSSVCESAAAILGYFHNATVQVSRESSAQRGLPDSSSSIGSVKLEIDSTEEQKGKGVKRKADTTTSFDEEGPSMKQPIKREVRPIKKGPAPVDYAQFKPLLKGKLNERMKFCQKLLNELITSKKCKAFNWPFLEPVDAEALNLPDYFEVIKEPMDLSTIKKKMDARQYTSPEEFRSDVLLMSRNCFTYNPEDQPVHKIGKQLQLYFNSKWRHLPADVPPESSQIALPTAALPPKEEKKDALPKTTSSNKTSSVSPSALLKQFKPVDDDEQIDFLLLQVQADQSRTNERQTQLQQFNHELMQLKLRRREARTHQQTPPPLSAELHTAIKSLLNACLPNSISSSFQLPSCTGFMPSLLPSSSIPQMPPATPTISLSQPTKKKTGPGRPRVTNSSSSSNLIGQQTTESSSSTPAQAQNIPVSQSHQIPAVQQQFTPLDAQSGRGRKPGSKNKPKTESQKEELSTKEYEFNSEDEHSSEPMTYDEKRQLSQNINNLPGDKLTSVVNIIKAREQIKDLNPDEIEIDFETLKPVTLRELEAYVKACSQPPDKKQKKASFPAKTLHSDQPKKKDSDPRIQQLNGGAQPNAKLSNGDGQLSVSSTTAFAGRPTQMLIAPNEDENSSSESSSESEEKPNQLKPPAPSVVQSADLHKAAIARSVLPPPLVQQQQMASQMIQSKSTPQIGVGGGHSHGSVKDLVAVTAASKAPTLMPPPSFTQISAGIAGSVLDHLLPSVTNDDRGVGIASGLLNKNSWSSLAQKAAEGGSQMSTGTNTTNAYELFRKQAREKEERKRQLKEEEERKKQQRERERQHLQHSASGESISAPVDGQQQQKVKISQEEVNRLREIEKERRKREEMEHVDMTSQMEVMANFEEITVVAPSNVSAGRQAVFGRPNEAPPLLSAAVVFTIIDLMDTEAESSTAFNAVEISGTIDPSRVVSDLMWLTEQCEQRCMFECVKWSVCCHFEGGGVSLKAMFDQLCASFDRQQRLRPSEFFLSNDEQMTSLEAFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV63</accession>
    <name>A0A914GV63_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GV63"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11482.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11482.t1"/>
        <property type="gene ID" value="Gr19_v10_g11482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11482.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40545" checksum="AF268ACF9BAD7EF7" modified="2023-02-22" version="1">MSDNPKKVEKQLEEISVCDDLLFEVFKFCDPFVLGLKVALISDTFDILVDAHFNLMEWSLGHLDICRAKKGNGAQIVKRFDWGYKVGRRLPIPRKKLPGKVIGFQCLEINYIDRSAIEFLQRIRKVFDSKGINLYIGTDTDEDRSWQIIWKKIWPLIKDNICGFDLNSSTLDRLRLFSPTVLRNCARLRVIDFCHFLEFPADDSAGASAKQAVAKWLHTPRGDGLPKVLRCIFHPERMEGLKMAFVDSFEQVNFVIGLYVVGKDIKPFELANNLTGERLEFRHLKKDKWLLIRRPIERDDEKWAEWENEAAELGCFCQWNRISIYFEDGGIDDGGRRKRRARVSKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVP1</accession>
    <name>A0A914GVP1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GVP1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1162.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1162.t2"/>
        <property type="gene ID" value="Gr19_v10_g1162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF33">
        <property type="entry name" value="PROTEIN OPTIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="483"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="485"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="728"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="728"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1162.t2"/>
        </source>
    </evidence>
    <sequence length="818" mass="89695" checksum="2CAB953033A02962" modified="2023-02-22" version="1">MLNPATLQQLWTTVFTPQNIANSAGGGNGTPSTNSFAQQMFPIAATAAAASTHHNRRRQQHNNNNNNPLETSKTPKQRRHLRGREEGSHNDNGHNDRVEEKRRRRGQQQQQQGDDDCYGDGVVDAEQRRSPVVVVVDGIVVPPAASSSSTSSSSPASTQPLSEKQSVAAAVRLDIKKEENSGDGTNRSLVDEEVDEYESDRRNRSSSNLPPGMGQPTADGGGGKGATPKRDNAGGGDKSQSTQSKREQRFSEDGELKEEKSGISPPTNSTADAKIQAQLMQNYLHKMLCAITHQQLSRDNNSQAQLLISRTTTGSPATASTTMAKAADSAASSSHSAAPAVVAPPNNAAIPSGSLFPGIPFPKMVFGINTVEILKQCELLEESNDVEKLSRFLYGLPPTVQMHIAMHEPVLRARALISYNTGNFKELYSILESHKFSQQCHQKLQHMWWDAHYQEAERMRGRTLGPVDKYRVRKKYPCPPTIWDGEQKTHCFKEKTRTMLRQHYIQDQYPNPAKKKQLAEETGLTAMQVGNWFKNRRQRDRAASAKNKMNGGARLPLGLSPSPKHGRNNGGSGSNNNQNDSCDSEFDDDEMRSFSHSHNSSEPEEEEDRMAVDDAFGCEVGESTEEATARKQKHFTIGQLTTTAAHSHEEQRLRLQNVQDDGRRTGDGEQFIGCGSTMPSAMPAAVFPASVAPPPAATPFNPLHLLFLMHSAAAQQTFLMNDFHNYHHQTQQQPKNEQAVSKGTCSSHSTPSSTLWPKQQPTTAENNAGRNVMANSPESTETKGQSAGGRKSFKLSIDQLLSSKTNGKHQIDQNPTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW17</accession>
    <name>A0A914GW17_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the actin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GW17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11861.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11861.t1"/>
        <property type="gene ID" value="Gr19_v10_g11861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11861.t1"/>
        </source>
    </evidence>
    <sequence length="682" mass="75564" checksum="D43863475D6904CA" modified="2023-02-22" version="1">MAQQQAITKKRKAVQDGIFKAELNNFLMKELAEDGYSGVEVRRAPSRTEVIIMATRTQSVLGERGKRIRELTALVQKRFGYSAGQIELYAEKVSSRGLCAVAQCESLRYKLVGGLAVRRACYGVLRFIMESGARGCEIVVSGKLRGQRAKAMKFVDGVMIHSGHPVIEYIQEAVRHVQMRQGVLGIKVKIMLPHDPKGQQGPRNPLPDHIQVKEPPIDVVPTTPYSEHRDQMPMPMGAPPTAPQLQPPSGQMSGGVYGGDDVGALVFDPGSHSFRVGYGGEEFPRYDIPARIGVRPLPNVVDDPSSQTTTDATIEEVATGRKQQQRDGIKFEQYIGTTRLNLPRADMEVKPYMREGMVEDWDLFEKMLDYIYGPCLGAESREHGALFTEPPWNPKEKRQRLTELVFEKYGAPAYYLAKNAVLAAFASGRTAGLVIDSGATHTSAVPVYDGYCVTNSVVKSPEGVDIVPYYKVASKREVKEGDAPIWTTRANLPPVTQSYESYMSTQVVEDLIQSILQLCEAPIDYEFMDKLPAVQYGFPCGYRRDFHAERAKIPEALFDLKHADLSETERATLMSVAQVALTSCNTCDIDIRPSLYSNLIVTGGNSLIVGFTDRLNHDLAQNCPSTIKIRVSNPNYSTSTERRFGAWIGGSIVSSLGTFQQLWISKGEYEESGKSIVERKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWA7</accession>
    <name>A0A914GWA7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clu domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWA7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11357.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11357.t1"/>
        <property type="gene ID" value="Gr19_v10_g11357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="3">
        <location>
            <begin position="350"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11357.t1"/>
        </source>
    </evidence>
    <sequence length="1223" mass="138552" checksum="534F26A2652F68F1" modified="2023-02-22" version="1">MATEIAANPIETVVVDDKSEGSEEKGRVVEETDPATHTDSGHESSASVCTPELPSTPVEEQKEEKFAEKQSFIVSSANSRFFRVRVLVPGGESIDVQINESDIVQELYHMLLERDSTCHRTCFKLYYDGTALDHFTEIRNVPGIKDNAIMRVIEEPYNLREARVHVRHLREIIRSVDISDASTSDDSGRKSKGSSAIELLRTESDCLPPEWLLPNSTDVPFKPLIPIAEHSNSCLQPTQLLALKQISFSAFNPPPGPRKMKGDILYLVVDTVEDRRFHVTCCTRGFYVNSSIGENLFDLLSDISAHFKKTFAQLLKLRNEKHIFERLPTPYQLFQWIIPSVENSQDQLRADEQIQPHRLGLEDHMPGQIRDWNEELQTTHDMPQNNFAEKLCRDRARFKVHADFLSACVIDGSVHTINPMDEPRMHMFIWNNIFFSLGFDVKDHYKELGGDAAAHASYAADLAAVQAYAQIDDPKLHTSGMAIVDFKGFRVMAQSIIPGILEREQQDSIVYGSYDSGKTVTSIEIYEELLKNSAKILKIEPHLVWNGKEGDESKVVKLFSSYESKGIVGNDRRHYLMDLLRTFPPDVNFLESAEPTEFCKAQGFPRKFKHKLVYLRQELVDAFTDFKNEQAKEEKDIKERQRKVENEDAPTDTAQEVEEETTDEPDVRLNPDAWSTAVRHAPQEDVQAHRKLVAEAAEHLLSHQIPQFVRDCVQLAVSPVDGLALTEALHARGLNIRYLGKLIDAVQSNSRLDYLTTVVKVELLCRCLRHIFREYVQGVEIHMMGAAIAHFLNCMIGSGKSVGPISQYDSDPASGTTQKKSTGGRKKKKYGYLEKGHVIGAGSGPTPKTMAWTKLSQDILWKSIGDDSHTHFGFRIPSDCCDSFVEWSGGAQRSAIIRRFCIMNGVQIMLKNYQLNPLKAKSQAPFSEDDVSNVVPVVKRLNPRSQSAYNLYLSALIKMQQGFIRIGYDLMQQAHSMMNSIYGPLHSDLALCLRFMARMAYALNDFPDALTQQHRALLISERCNGIDHYETISDYINLAHFSFANLCIPSALKLLYRARHLLMLSHGEQHPYMGQIDANIGIILYALQEFDASLKFLNNALTLYQKYGVPVKTALLHHVIARAHSCRGDFRTALIYEKETFNIYSRVFGKEHEKTLVSNECLRHLTKQAVNFQKHMNDATQGLKTSKSLVPNFQIQPPSLPNIVELLNAFNNLLFWKLQIHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWW5</accession>
    <name>A0A914GWW5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914GWW5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11915.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11915.t1"/>
        <property type="gene ID" value="Gr19_v10_g11915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF71">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11915.t1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38157" checksum="CDCB4262D2ACD97F" modified="2023-02-22" version="1">MFCPIYPNLDHLLQLLAVYHHIFLWIGLPVLSVSLPFYIFFFTRFWWAVVVYFVWFLYDFDTPRRGSRNWAWYKNATIWKHFSDYFPIRLVKTVELSPNRNYILGCHPHGVFSVGAFVHLCTSATGFGQLFPGLKSNILTLNGQFWFPFRREIGIGLGGVESSSRSLKFLLSNPGRGRLIGIVIGGAEEVLDAHPGQHHLNILGRRGFCRFALKTGTSLLPSYSFGENDLFDQYPNSRGSRLRTIQSSIKRKCGFCIPFINGCCGFCDHFGLLPRRRPITTVIGAPIEVKRIGKPTPDQVELLHSHYCNELDKLFEEHKTKYGVPNDVHLTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXP5</accession>
    <name>A0A914GXP5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914GXP5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12112.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12112.t1"/>
        <property type="gene ID" value="Gr19_v10_g12112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="139"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12112.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39803" checksum="72EADF49D7879DC4" modified="2023-02-22" version="1">MRTDRSPPTPHATKDWSNEVPFGNWLMEQCLGNKCVRCVIGTFRWVPVLFVWAIICWAYYTYVVAFCFGMVGPIGVKLILLITVISPIGRPPELFNLPHQIRTELGAATNEIEFKAILERFARDRKIPIASRSNDGAVRCCLKCSCVKPDRCHHCSVCGHCVLKFDHHCPWVNTCINFNNYKFFMLFLGYGSVLCFFGFFTILPYFISFWQRGDLSQTEVSRFLVFFLFFVAGLFGLSMGCLFFYHLFLISKNRSTIESFRPPIFTHGADKCVYNLGVRRNFEEVFGSDKRKWLLPLFSSNGNGTAFRNSAEVFRSRYSPVSTIGHLTGSSSSEEDDYDHEMRTLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2024-03-27" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXZ7</accession>
    <name>A0A914GXZ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g11414.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11414.t1"/>
        <property type="gene ID" value="Gr19_v10_g11414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37156">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37156:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11414.t1"/>
        </source>
    </evidence>
    <sequence length="1407" mass="163096" checksum="82D5DA0B746C54C8" modified="2023-02-22" version="1">MYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQIMYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQIMYQILYIPPNQILSQKLYIPPNQILSQKLYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQIMYQILYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQIMYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQIMYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQIMYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQIMYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQIMYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQIMYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQIMYQILYIPPNQILSQKLYIPPNQILSQILNCTSRPTKSPNQIMSQIVYIPPNQILSQILYIPPNQILSQILYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQIMYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQIMYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQIMYIPPNQILSQILYIPPNQILSQILYIPPNQIMSQIVYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQKLYIPPNQIMYQILYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQILYIPPNQILSQKLYIPPNQIAQPNNVPNSKLYIPPNQILSQILYIPPNQILSQILYIPPNQILSQKLYIPPNQILSQILYIPPNQILSQIMYIPPNKQRFSFSVLAHYLFRILTRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYU4</accession>
    <name>A0A914GYU4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GYU4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12447.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12447.t1"/>
        <property type="gene ID" value="Gr19_v10_g12447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12447.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33867" checksum="D4B3EE7DE9BF99D1" modified="2023-02-22" version="1">MSNQFCGLMDKMEQDQNEEEKTLFKEWRHNFELKLRQHIEKFEEHKKFESIAGSRPTILKRGTEMRGSKPKRKAIHFSEILLIREIIIENIEPGEIVQLGQQQKFVLEKLKVELLRDFCVRMTPRGRIVPKSTRQILTPETQRFTNRHEISGKSTRKAKKTALGRASEGYATIEGGEEGDKVPTVPSPKTVQLRPRLPTTPIPRSLPASLLASPSTPQQDIMPTAATLLSAPAHLEQPATSTEPLAMLPSGCWCPLGTECQALKASTSAHYSLLCRDGKVLAKAGESTDGYDEAADVMPETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ13</accession>
    <name>A0A914GZ13_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZ13"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11712.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11712.t1"/>
        <property type="gene ID" value="Gr19_v10_g11712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11712.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7685" checksum="75660D24F4E0F5C4" modified="2023-02-22" version="1">MLRSALPVPSYRSATARQTRSAYRNQQQQQQQQQQQQQQQQQPTKSLCGVCVLVVVAEVVPSSRSAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZL3</accession>
    <name>A0A914GZL3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GZL3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12270.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12270.t1"/>
        <property type="gene ID" value="Gr19_v10_g12270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="311"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12270.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44000" checksum="D57FB28D334C84F0" modified="2023-02-22" version="1">MQPQQHSGINWWKSRTDEFSSKMKQDKRTENDMEIEFLGMTPSSHREDVVHGSANACISNHSPFSAAVPISFQQQNSKSAVVAQRLAEAERHVLSLRRQLKQQQRQEAQMARRNAELYKKSDGHEMESAKQLNNNGGLSCWTTAYESLHNNASSVANGPGTLHRPHRNCYSGTAASSVLCAVQHPSFHAADRSRTVSGGTLPAVNSSASSSTTAASATTTPSSSSSAPCPRATVSGDLATRQWLMGQKIRCLWKENEYAAKIVGKEQVMGRLFYRIHYVGWTTRHDETIGQSEAMCRFRDWDESELPPGVFNIDRISGMRKRKNREEYRVHWEGYDSADDTWESASKLLSDGCGWAIDEFKQKFAPVKDEEEQQRFSVKRKRSGSAFKNEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H034</accession>
    <name>A0A914H034_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H034"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12699.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12699.t1"/>
        <property type="gene ID" value="Gr19_v10_g12699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12699.t1"/>
        </source>
    </evidence>
    <sequence length="395" mass="45062" checksum="C307F24310E24992" modified="2023-02-22" version="1">MANRPNILLDRRVVGFWAYSAEQTKTSGAKRRPGQNGGRAINGGMAKENAAGRPIFCCCFVCADVLFEVFKFCGPFVLGLKVALISDRFDLLVDAHFNSKEWTLGHLEIQRADDGKGAEIVKIVYNDYERCVERRLPIPQEPFPDNVIGFEGLKISNIDQSVIGFLGLIRPIFNSNGTNLTIYTKDDQNRSLEIICEKIWPLVKDNICGFRLLSSDLDNLRQFSPTVIGDCPKLRVIEFFDLFPEFPADDSAGASSEQAVAKWLHTPRGDGLPKVLRSSYFDSEKMEGLKMEFVNSTNPVNFIIICLWCCSDDVVPFESRNNLTGERLEFRHFKNNYWLLVRCPIERDEDKWAKLEKEAVEWEWYQGNLIIIDFKDRDIAEGNSTLDFDTDGFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0Q1</accession>
    <name>A0A914H0Q1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0Q1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12549.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12549.t1"/>
        <property type="gene ID" value="Gr19_v10_g12549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="295"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12549.t1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48384" checksum="CE2695C368340572" modified="2023-02-22" version="1">MPKPNSLVGRIKHLLSTGDDADIQFLVGGGDKKEILSAHKLILKTASDVFETMFRFDARNAKADAAGREIKPVEVPDVEVGAFKAMLSFIYADDLSGLNGDNAMAVLYAAKKYDVAGLTKACVAVAIPKLRNVFVAFDQARLLEEKDFSRRCLAYIDKNADTLLLSKLFLQIEQKLLCEILGRDELMTSKEITIWNAALRWADEKCRQNSKKCSAENRRAMLGPALFKIRFSLIPQKDFSEKIVPSGLLTDAELVGVYLHYSHPDVTLPGLYPRQFPTKQQLPAKSLNDDPYKANGKIMLKIEKVSKFARQDENSRQLSEAVYIRGRPLKILAQPSRKGKGKYLGFFLQCSTESNWSCACSATLRIVSQKAGKKDFTQEISHIFHSKASDWGFEQFMPFQQLMGSKNGWYDAKNDTVILEADVTAYKSLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0R9</accession>
    <name>A0A914H0R9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial basic amino acids transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Carnitine/acylcarnitine translocase-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Mitochondrial carnitine/acylcarnitine carrier protein CACL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ornithine transporter 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 25 member 29</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) = L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:72807"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:72799"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:143006"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-ornithine(in) + L-arginine(out) = L-ornithine(out) + L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:34991"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:72803"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 23">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0R9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12974.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12974.t1"/>
        <property type="gene ID" value="Gr19_v10_g12974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005289">
        <property type="term" value="F:high-affinity L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000037">
        <property type="entry name" value="Solute carrier family 25 member 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF61">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="10 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 22 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 23" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="95"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="199"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00080567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12974.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35126" checksum="75CA9E22FA1EC529" modified="2023-02-22" version="1">MPSDILVDFFAGCLGGVAGVLAGHPLDTVKVRLQTQNSHSPIYRNTFHCLTCIVRNEGPSALYRGMSSPLASLTMINAVIFSVHGHISKQFEDPNALHVQFVAGAVAGATQGFISSPMELLKLRAQICHEPTSLAAPKRCSSSPLSMARQIWREKGLRHFSRGLLITQLRDCPAMGVYFASYAFLRRKTDAGSGEQQRLSNLQLLFAGGAAGMCSWLCNYPADVVKTRFQADDAYSNYREVIRKAYAENGWRTFFAGLGPTLIRAIPTNAAIFFTVEWTYRILLKARTIDQKDKALTRHPPPAICSQWRRDALCRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1J9</accession>
    <name>A0A914H1J9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1J9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13064.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13064.t2"/>
        <property type="gene ID" value="Gr19_v10_g13064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13064.t2"/>
        </source>
    </evidence>
    <sequence length="171" mass="19372" checksum="7E6F3E5A618A422F" modified="2023-02-22" version="1">MSSPPATLFSILAINSRAVRETAACKNANDVENAVKSALNSMGRCPNGGGGQIVNEIDAQLSSTDGCAYSLSFVKAMFELATSSCRPCWQYIISLGQFESKVWKTNWRHSQHWRYAQHSHYGRVFQQAEQRIEMVVYSMKWCTSKCATPEQCDFQPRRFRRTQALNVYAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1N5</accession>
    <name>A0A914H1N5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1N5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12837.t2">
        <property type="protein sequence ID" value="Gr19_v10_g12837.t2"/>
        <property type="gene ID" value="Gr19_v10_g12837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18416">
        <property type="entry name" value="BTB_Shaw-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF245">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EGL-36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="158"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="630"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12837.t2"/>
        </source>
    </evidence>
    <sequence length="728" mass="83476" checksum="77AEF51CF4A23124" modified="2023-02-22" version="1">MGAHFGILPYPLHSPENKFWTKMKLSRSHFPAVAACQNGRSDFEQRAVANRLFSGNWAFNHQHVSITFNTFSNCLRVEAAVPPLQHKLGEDAIIIYCRALLTVRLPLLPPTTTVPTTDEMFLATPVTLRSGVCSRRPSQMLIDTAKMIERLPVPCMDERVVLNVGGIRHETYQATLKKIPATRLSRLTPAQSNYDPMLNEYFFDRHPAVFEQILNYYRTGKLHYPTSVCGPLFEEELEYWGLDANQVEPCCWMTYTQHRETQETLAVLDKLDTDDLKDEDPQTQEQHRMKKFGWEDAFWEGRLNWWMRTKPRIWALFDEPYSSTAAKVVASVSVCFICISIFSFCFKTHPSLRIPILQISNFTEFTSSSTLPQHYHQQQQQQHQQQHQQQQQQYHSYASSSNYNQPINVQRVATEPHKIFAQIEFVCNIWFTFEILVRFICCPDKLKFFKYPLNVIDLVATLSFYTDAVLVRLLKDQAPKDLVEFLSMIRILRLFKLTQHHRGLQILIHTFRASAKELMLLVFFLILGVVIFATLVYYAEKTETNPNNQFTSIPVGLWFSLITMTTVGYGDMTPQTHLGRLVGSLCAVMGVLTIALPAREKLPRKRRRVLPAEQVRLQFRRHAQSSILESNTLSRVTSTRRRSANANANSEMAVEPKMAPLLMNNIGPRPSSDDAGEHSPSRRCVAHQRSPSRSPQKRLPSTRPSPAASPTRKKSLSGETKVNIYAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1Y4</accession>
    <name>A0A914H1Y4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H1Y4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13397.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13397.t2"/>
        <property type="gene ID" value="Gr19_v10_g13397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000248">
        <property type="entry name" value="5-hydroxytryptamine receptor 1A-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF151">
        <property type="entry name" value="TYRAMINE RECEPTOR TYRA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="84"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13397.t2"/>
        </source>
    </evidence>
    <sequence length="619" mass="70340" checksum="D6D6604DB0CDD495" modified="2023-02-22" version="1">MHGKSIRSLHEFGGLIINVSRSTHSSRLLLADVLHEHLVSFSLRAPNSSIAFSSPPIHDQRIIPFANVLKASALTLLVAWTILANFLVFIVLYKNPRLQTVPNLLVGNLAFSDFCLALVVLPLSSIYACAGEWIFNDKLCQLFVSADILCSTASIWNLCIVGLDRYWAITHPVQYLNKRNKKTACLMILSVWSFSALISLAPLLGWKQVAEHGNLVQIDGVWQCTFLDLPSYTVYSATGSFFIPTLLMFFVYFKIYQAFAKHRARQIYRQKVIRRHIESTILHEISHILPTSDEFAKEVEDEEEEDEAEEEEEEEHGRDAVDEHVQLEHDREKAQRGRRVADPLHPIIYEENEEAEAKEENGSANREEQMKGSGAGHILRRKLEERNGRATNANKVSTAKVAFKREVDMPEQQQKVSILVKSEKQRRWFSYGDEPPVAGSANTVESTKAGGLARNAGTDRCHRPKNRPKDGASMPPYEKVRRHKRRKELNFRKSLQGKPRAISAAKERRGVRVLGIILGCFTLCWMPFFIMYVVLQFCSDCSVNPHIEMFITWLGYSNSGMNPIIYTVFNRDYQIALKRLFIAKKRSVTGSSVVTGETGRPRKRHILPTINRPHLTESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H257</accession>
    <name>A0A914H257_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Autophagy-related protein 11 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H257"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13303.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13303.t1"/>
        <property type="gene ID" value="Gr19_v10_g13303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="5">
        <location>
            <begin position="923"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="835"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13303.t1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121091" checksum="D7D6B51EF4BD671B" modified="2023-02-22" version="1">MFHIFYVNRGYMLVLEPPALGSVYDLQKCIAGSINVDINEQYLFLSGGASINRNAMLSAISDVGTDTNPIFLVRRVTNVQPESTKTNADGINDIYQDWELSMDRMLGIVSTNSSSAISECVDLGRKCAHLAENIVRFCSNVLVEHRFLYQGWMSVISNLDENILRIQRRLDKSLGQAIKLETYRQKGRCLMNGFDKVLEILRKIVIPPSLLLPAHSSANLSDSEGSVEEITLFDWISSKDPAYSLTSFSQHVLEHLEKTTNEELSEAQNLLAMVQDVAQKTQYRDIRGIDKRLATLNAHLLKLEGSLTEVRETTAAIIQPIIQDGTQNVVVGQKNRLKELKGKLSEQRNCALSFINSKDEVIQNICQRLATWIRQAYQRLQDVDKRVMCFDQKFGGLRQRMDLARQITETPSIYMTAVPEVIRREALKKEFAEWMGLHIAKTSEFIAEENKIRQHFFGKLDRHFLRQLFPGMDDVIPQFSPKTTPKIDELLPKVHFSHLHELRSRFPEMKELLVVGAPNLVSRLAIFDPSLPSPMATLSSRSMRREESFYVRDKTSNIDAMNRNFPSTNWLSEESMGLSPSPSGASNFLSMEQRGGAFSTSSASIHSISGMELQSPQELGPLGVHFDASVNTSETTNKNTRSSMSPLQPSAPIAIPSNSQSNPVDPMESLGSNQFSTPDDTFGSLGSTCGGRFVNVKQPYRPTSPKVVRPKSMLRYQMCSQLVHKEEDEKHYNDQEMEIQKEKSAQTNHKFHSKLVYALTGLKELSEEISSVRQNTEELGKAVVVCLSKPEIITSEEKCLQKIAEIERKCNSQIMDITNELQRERSLLIEKENAIKEQNEVVSRITNDLKVLTRERDQLLEKVKRDGEQRQQKNVTAEMEETDTQPIDVISSLAIEEISTKEPLVAPLSSNSGSDEDEGVAQLSTRSYGTQTKIRGKDMQTFISLNELYEGCGALIIWNSHLNAYVARSTSSPNSPYIVKDSSFEKLGIRRPPRPIQATDENSAVFSHSVSMPRPWMFVLVESIEMCQIRKATNRYNLPLDTRFYRISVLPILGDFVTAVPMSTTSSVSSSNARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2X0</accession>
    <name>A0A914H2X0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2X0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13372.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13372.t1"/>
        <property type="gene ID" value="Gr19_v10_g13372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="42"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13372.t1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50377" checksum="30C89EC041EDD8BE" modified="2023-02-22" version="1">MGGTIFNGSRDEHRLLTIFKDYYEIRALSCVLENNMDDFEQAIKDVLQFYSNCGDATDLRVDAKFQQRYLMYGLFLMYLLGSNKLAEFRMLIEQIDHSVRVKDPYLDVPIKLERYLSDGSYNKMFLTEKNLPTKYYIPFINILKQAVQNEISLGLETAYRSIPIADAAKQLIMSNAEVLAFGTRNNTTKSVYVSGSDPPASAQPPIQREQPANPPRAESVSIDNCRILPQRLYCRRLRLRHVPCPKQTSSVERDGLDFYGTLFPRIPVPIQKDIESKFGERAKLYGYEDERFGGVGRKRSRSRERRRSRSKEREREQRRSRSRERRGRSRSRERGRRSRDRNRSREALVKTDASSNGELKASAASVGTEQRKRQHKSKCHHHLRHHHCIKHRRKCPSKAKKTINNGDEEKKDEEKSSVGVCVSAVGESGEQQLANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H352</accession>
    <name>A0A914H352_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H352"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12820.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12820.t1"/>
        <property type="gene ID" value="Gr19_v10_g12820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF61">
        <property type="entry name" value="IRK_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="100"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="246"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12820.t1"/>
        </source>
    </evidence>
    <sequence length="601" mass="68070" checksum="36B488C84280F3AB" modified="2023-02-22" version="1">MRENCAGSEAEVLLASSPRATTTTTSTTTAAPANCINNNHQNHHQQQKPDAMVLNCAQNDMEKGLVRLPVPASRPNRRPSKKHKDSSASTKLVPKWPRLVAKNGECLIRPNNLRNSYTICMRNWFHLIIEHSWRRIFGLFACSFLSSWLTFGFFYYLIVHYSVEIQDLSENRQCIANVHSFTSAFLFSLETQHTIGYGTRYMTEGCPLAYVVLSLQCIVGVLLQTVLAGIVTAKILRPKKRKQEMRFSVQAVLGPVDDEDPRPALMIRLADIQHRLYIAESHVRLYMATTKINKRGECELIGVQDMNVGYDTGMDRVLLLWPVVIRHIIDPDSPLWEITEDKLNSCRFELIMTARTSFLPEDILWGRRFVPMITLNSDTNQFEVNYDLFDVTEPHTVEPWLPPEEVFTDEECPRETKLPLITESEDANSRPTQRLPTAAVPTAAHYHYHNHHNNHMPNGVLEPPRGHYRFRRKSACSVVSRGSLDGVHQPQSRKTSKGSLLHALLLRNEIRSGANDSSPLVASSGADDRKQSDNSFPLWCTLCSIPGSLEHARKSERKKRHSLNTCKINSPPPQMISNVLIMVKTDEINPGIFQPDAANSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3A2</accession>
    <name>A0A914H3A2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Skp1-related protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3A2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13600.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13600.t1"/>
        <property type="gene ID" value="Gr19_v10_g13600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13600.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22461" checksum="6A5808FD42892967" modified="2023-02-22" version="1">MGAEKENTPPAAANTSKQSTSAASEEKRLQNEVKCACSDGDVPVRLELLPQCNIFSDMTKHCDLSTVKTEDIVFSIPEVSVDTFKKVVEWMEQRAGKDEPKIETDPNTYERKWFKLDDFETKFFEMDVAELANLLSACNYLQINSLFVYACQAMAALLKTKTSVEELRNFLGIDENDWLSEKRMAEIREKNAWYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3S3</accession>
    <name>A0A914H3S3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3S3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1358.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1358.t1"/>
        <property type="gene ID" value="Gr19_v10_g1358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF4">
        <property type="entry name" value="GH23156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="3">
        <location>
            <begin position="59"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1358.t1"/>
        </source>
    </evidence>
    <sequence length="533" mass="59745" checksum="80EBF3D7B50E69F4" modified="2023-02-22" version="1">MSSFYEASTSGMNWDRFTADVNDSLLSESTTLKVKQAYWSAKQLIREKLGRREDEHVVAADAELDMHLQQFRQIRDSTQTLLTLMETNQRELNDLAQLELDMAELLTDAQKDEKAHLRSVLQVTANAQANSSKQRQILLGHVIRFGNVLYDFIERAVTDCEQTVEARARLDYRGSLLWLKKSSETLDPADSSHMEDFRTVQQVVKGQKHRMDLLKEDVTLKVNVLHEARNRILADHLEEYKTALVLFHSDLAAEFCASSEQFDGLESYEIDVLKILRDPIGLAMEEQHNSELDTTSSPKRFKSPRPSSSRNRLHSESDTNDLVELEEVELGVEACDPAMERVRELLRFEDDSEDQAERGHMPVENNLLGLAQSDVQWKSPPTAAGIGLNLLKHSSSSTTELLNELQQEWGSLAGCSSSNGKQAVNIAIDEQTLKSAKPGTGRGALLEEIEDLLFESCPSSPKNNNSNLESNLDLDTLTFFESRTVTVGNNFELQQSFNDLKCAKTEKGVGAENVPKLAPPPSHAATLCIKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3W0</accession>
    <name>A0A914H3W0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3W0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13607.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13607.t1"/>
        <property type="gene ID" value="Gr19_v10_g13607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13607.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8182" checksum="01857B611B14E670" modified="2023-02-22" version="1">MHTNWRYDNCGSAIADGTIADDNCGRQLRTRQMRTTIADRQLRTGQLRTTIADDNCGRQLRTRQLRTTKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4V1</accession>
    <name>A0A914H4V1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4V1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14177.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14177.t1"/>
        <property type="gene ID" value="Gr19_v10_g14177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14177.t1"/>
        </source>
    </evidence>
    <sequence length="465" mass="54567" checksum="8F5E7B854EF348BE" modified="2023-02-22" version="1">MNDLNCFYSAKMVFVFILMLSLATLEAQRNENDKFFDLMTAIGEHLGGEFNDTEKALELDLNEYVQKDVEENCKKFENEEAKIIFLNNVHYELAINFEFNQRKDIYDRANDLLSDWVGNDVTMLRLNLLPLSEEAYLKKNALQMLRFALMNNLCFFYLAKMVVVFILMLSLATLEAQRNENDKFFDLMTAIGEHLGGEFNDTEKALEALVHGKNIDGTLKEKEENPKDKIQTFLAVPKCFQESELKIFDYWIEIIEMKTKNSQKPIFGVAIYKEKYGLNKSEDSKEKAFRLSRENYKILKHENEEAQIIFLNNVHHELAINFEYNQRKDIYGRAKKLLSDWRGHLSEELYLEKNASQILHKIKNLTSEKKHRESISIIEALIGNEHFNQFNLGALFDEIKWLVEVAIPEEEANIAEKMKKKNTKQLENDIKFMKPNLKEQARTLAKTFEKMLQNVKEHYAQKMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4X5</accession>
    <name>A0A914H4X5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H4X5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1402.t2">
        <property type="protein sequence ID" value="Gr19_v10_g1402.t2"/>
        <property type="gene ID" value="Gr19_v10_g1402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_1"/>
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    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="7TM_GPCR_Srsx"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
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            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="246"/>
            <end position="267"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="585"/>
            <end position="605"/>
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            <begin position="628"/>
            <end position="647"/>
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        <location>
            <begin position="79"/>
            <end position="644"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
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        <location>
            <begin position="330"/>
            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="452"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1402.t2"/>
        </source>
    </evidence>
    <sequence length="683" mass="75827" checksum="1A0FE943DD98CEA0" modified="2023-02-22" version="1">MLFFISLAEQSSTVLAIGTASVSRLSSPQFTTHSANVAGGAANGATAANQQPSNRVCLGFADILIAFILILLILATVLGNVLVVLSVFLYKRMRTFTNFLLTSLATADLLVGLLIMPLALFDLLHNHNWPLGKALCRIWATFDVLLCTASILNLCIISLDRYMAITSPLRYPRTRSRWMACALLSFVPLLATADASALARLSLTLNKMPMLSSTVSRGHREQTTTALLLGDGAYQCAYPMSVSYRIYSASVSFYIPLVVMLFVYFKIFRVASERERLIREGMGTCRLSRRVEKTQLKGRKRSATTNYTRRSNAPRIHEVIQNIASPTLTACGGEQDKNSSANHCSAPAYSKHPSRPNPTPGALPPAQLSEDRPSSGQMSPNLRSSILRPGDYDSEETICPPSARTSGRSATPAAARNGTKKATNILASSQRCATDSFRRKIKSMECLGTLGNYSSRVSTNYRKNSADPAGDDSDDDESDMQNECQQQRRVQDNNNKFAQRSLQNLQNLQPPAPVNRLSNGAKQLMRTANNNNTFGMVNCTTGSNQQARNSMAVLQQSHFTTKNANFRGSKEKIVYLRERKALKTIGIVVLGFIICWLPFFVVYVLEVSPVLKKWDVIGKKEFQLLSEFFLWLGYSNSVLNPLIYTMYNSDFRRCFRDLLGMGCMNQHRRTMSVKKLHQQSNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H566</accession>
    <name>A0A914H566_GLORO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
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            <taxon>Globodera</taxon>
        </lineage>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H566"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13769.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13769.t1"/>
        <property type="gene ID" value="Gr19_v10_g13769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13769.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26682" checksum="8AAA5EA3F8665757" modified="2023-02-22" version="1">MKLYEINAIRDSFQKWEAMLEGAELPIELLKSMLANQCQQICMLAKKSANVNVEDFEEIISQMDQYCCQNHNILTLHNEELIEKLALFEKIEQKMTQMVKKIEDSEKNDVTILKKKVQKTEKNSLSSEKAQTVQGVYKFLQSIEQKLGAGPAKKVLRKFLGKKLYNLLNSFNPSLFIYKPLIAVHAAFVILSLLMEMFVEIMAQPVFIALATLWLFNLLRTQQVMILNDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H699</accession>
    <name>A0A914H699_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H699"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14572.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14572.t1"/>
        <property type="gene ID" value="Gr19_v10_g14572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
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        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14572.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24385" checksum="346A06ADBE1C92BC" modified="2023-02-22" version="1">MELLLFRPKDFAKLYGCDGFNASQVPLSNRTNVVNGSLLILLFVVFEILYIPCMMSIYKNIDTACYKLLFFIGILDMLVIFMNGLETGILGIIGAVFCDYPMLIYTSGSVGLALWYAETGVELLLAINRCMELLRPSMAHAIFSGNKAWYLCAVPIVYSTVLCLYTEPILFSGIYFSWFFNPYVGYVDDFGQIYHSTPHTGRYFFLLLSFYFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H731</accession>
    <name>A0A914H731_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase A2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H731"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14299.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14299.t1"/>
        <property type="gene ID" value="Gr19_v10_g14299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053322">
        <property type="entry name" value="PLA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228">
        <property type="entry name" value="PROTEIN CBG09474-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14299.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16115" checksum="98E24E6A23F68CE0" modified="2023-02-22" version="1">MDWFCGSDRFNMFMSENAVTRDCPTRKNGFNNCCVAHDLCYSAQTGQINCDDKFCNCLAEAANGTRVCAAYEAKAFCLLVRQFGDGPYRASAPIILNINCTWSRCGFWFNTAKQLGCDCDGTETRGCGPLGIGRSYQCCPTCLGGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7V8</accession>
    <name>A0A914H7V8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H7V8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14622.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14622.t1"/>
        <property type="gene ID" value="Gr19_v10_g14622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="203"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="334"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14622.t1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46418" checksum="7DF5AF2A3EBD063E" modified="2023-02-22" version="1">MLSSIMLDATDHDVANGEANNETINSTTTWPKAHLSQRTLSDLQYRIQLERAINAAKLSMCMPKNTVADTRTAPNDTVDFHRIKTRLLDTLEKVRDTKNQQMLAKAGRRTRAQKAGAKPQQPHFGSMIISGTLQQKEGASLRQMLEAAKKRPSFRRRSISILSDSTIKAKAEEEEAKLEEMKLLEAEEPFFLRYCPLFTTLLFAVLIIVMGAVLFKTVDEQIGQKPFQNVLTFCFQALGTIGWGDVRAGSKWGQLLCTFYTLFGVPMFFSALANAGRALVSEFFTIDWIFLTCVVRPRRFDEPVINYHMPLVKAVHWLIVHQFVGLLLYGELFKHYRPIETLYFCLTSMGTIGIGDFHPDAANVLEAAVAIVFLGSGIGLLAALMIGIAYHFQSLFFITLRAWLLKQIRTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H828</accession>
    <name>A0A914H828_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H828"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14897.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14897.t1"/>
        <property type="gene ID" value="Gr19_v10_g14897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14897.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17846" checksum="284115501ACBE429" modified="2023-02-22" version="1">MSELRDRLNHPLDRDRVVQALNGRRVQTTYKDRNGYTKTFTFGGITSQGAATSMAYGRLGRPFNVNVAAHFYVRHRIKLLHPFLHCVVERFPEGQEDRFYPLELCKIEGEEMKLPDWLGNVFSAVRNNNNRDDTEEGGRAECSQTSDNSSSYSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9E9</accession>
    <name>A0A914H9E9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9E9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15020.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15020.t1"/>
        <property type="gene ID" value="Gr19_v10_g15020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037755094" evidence="2">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15020.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22948" checksum="971D0A7C77093206" modified="2023-02-22" version="1">MEYFWILIFVLFFATKSLDKAESVNVKLEETPLKTFDEIFGEGWWDKGEAEDLKTPPTIFGQNVHHQIDRQNTQIGQIEPNSTDQNPPLTESDHSDNAKNGEEQNKVSSNESIAEDERKHKTIAKELGLSFRTIYNWKRKLGQSKPKKYHHSEQKELMKRNLNDSNFIQILSMDILWKRMPRQMFRKLFEDYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9K8</accession>
    <name>A0A914H9K8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9K8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14533.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14533.t1"/>
        <property type="gene ID" value="Gr19_v10_g14533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14533.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27801" checksum="7000DEC075D85BA4" modified="2023-02-22" version="1">MTSDNQQLDLSLNAVDDNPGNDEQLQSEEEPEEASTKLNAVVSATTDGSVSSSSFTNSTCASINSRTTLGVNNNSSTSAAGRQQRRVLAFQLDGAVHRRSNASKNPIQMLSNLFSSMMGERSSARKYGIKRQILQRTRSSLRRPQLVSLRSRGSIYHQQGDMVDMDSNGGCSSNGRENAFDMLLRFCDKPADIAFLRNHPDHMERLGIPVEQYSTILEELNFFLIKREQLREAEQRVRQRKQKREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9S4</accession>
    <name>A0A914H9S4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914H9S4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14578.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14578.t1"/>
        <property type="gene ID" value="Gr19_v10_g14578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038153866" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="161"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="391"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14578.t1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57616" checksum="F21642AEF4DC7A0B" modified="2023-02-22" version="1">MKSANIGTGIMLTMLIILKLAAFTDQLQQNRIALNDPNRVPHWKIDNNINQGPFYGQPEQVHLSYGGEPSKLWVTWLTFDDTLDSVVEWGEQYNQLTRRTSAKIDYFVDGGTEKTKRYTHRALLEGLKPGQRYFYRVGSQFGWSSIFSFVGLQERPGGGFKYAVFGDMGNINARSLGKLQREAQEGGFDMVLHVGDLAYNLDTEQGQFGDEFMRQIEPISAYLPYMTVVGNHEYNYNFTHYINRFTMPNPENQNLFYSFDLGPAHFIAFSTEFYFWPIYYRYESLAAQWHWLIKDLEKANLNRHNVPWIITMGHRPMYCSDYSGDDCSRYNSIIRTGLPLVHAFALEKLFFKYGVDLEIGAHEHTFERMYPVYNRTVYNGSDTNPYVDPPAPVHVVSGSAGCQENTDTFVAHPGPWSAFRSSNYGFSRMHIVNSTHLYFEQTIAANETIEDHFWLVKNRHGPYDWTDRQRLLRHGTYVPQNYCHHPSQCNKTVAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAR7</accession>
    <name>A0A914HAR7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAR7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15356.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15356.t1"/>
        <property type="gene ID" value="Gr19_v10_g15356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036697232" evidence="2">
        <location>
            <begin position="17"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="61"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="281"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15356.t1"/>
        </source>
    </evidence>
    <sequence length="474" mass="52236" checksum="F5892AB3998507BB" modified="2023-02-22" version="1">MPTFLFLAAICLLVAASTLLETDASPKNKKLEKGSSSSGKAQSTPVPKANSSAGLRTTDSPDVHFLVGEGDEKELLPAHKAILAEVSDVFKAMFRYDEANAKAAAAGTGSSKKIKPVEVPDVEVGVFKAMLACIYAKNLSGLNGDNAISVLYAADKYNVSGLVKACLNFPIPELRNVFFAFDQTRFLGKEILARDELVIGEEIAIWNAALRWADEKCRQKGKECSAKNRRAMLGTALSKIRFSLIPQKDFTENIVPSGVLEEVEQAGVYQYHSHPDRALPKPYQLQFPTNKRALPGLTLQNRWDSAALHKKLALSEPARLIVQFIGEKEGWRSVLAERPIPKGKFGIFYYEVKILVEKDGIHIGLATKQMPLNTWVGRDKGTYSYDNIGLYWGHPAKDNGPSFDAGDVVGCGVDLATRQIIYTKNGQRLKTARLFVANSDADLFPCISMFKPRNKIEANFGPNFKFDIAKTFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAZ3</accession>
    <name>A0A914HAZ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAZ3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1492.t3">
        <property type="protein sequence ID" value="Gr19_v10_g1492.t3"/>
        <property type="gene ID" value="Gr19_v10_g1492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF15">
        <property type="entry name" value="INNER CENTROMERE PROTEIN A-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1492.t3"/>
        </source>
    </evidence>
    <sequence length="274" mass="31565" checksum="851794DFC701E000" modified="2023-02-22" version="1">MLERIFEQREAIFTYAMNETRDFRLILTNEQYEQIDLIIKILKPIQEISVRLFEFGFIDQIRSALVAGIQKRVLHLLSTVLELKFVGGKERNVMIEKIKLWIESEIVKKNGEEVQLDGSETDFVTPRSPPAKKAALENDSIFSTFDQITQNPTESTERTIEKEFAAYFAEGCAKHNDDVFALLRTYTVNYPLLSSVALKYFCIPATSCASESLFSSARHTCSYDRVIVYFLNAYEIPFYNWISEVYRSCAPPKLNLSDDHAAHLLKLVVFVFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB36</accession>
    <name>A0A914HB36_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB36"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15722.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15722.t1"/>
        <property type="gene ID" value="Gr19_v10_g15722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037540309" evidence="2">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15722.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24186" checksum="BD11E51B08297A45" modified="2023-02-22" version="1">MIFLLLLLVTQMLWTFAQWHNRNVPWPSPVSVRRHELSASAAAAAGKHLNWQETYAENMARFSSYHNECVHRCDEHFWRLSEWLAGVAAAASGTDVPTRPLMMPGWNAHGEWHADTKRCAETVATAEDSGAPAGHKKHQKNGNASGDAPPPPLVLPIVHGDFNWTHDGSAKNGSRRPMEMQPSVTLVLDRSSSADQRQKVILVDTGLPANRQAVLSGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCA0</accession>
    <name>A0A914HCA0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCA0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15285.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15285.t1"/>
        <property type="gene ID" value="Gr19_v10_g15285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15285.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13798" checksum="56F503879094D481" modified="2023-02-22" version="1">MGLTVYCPRHLKTPRLVPWDQPGRCSRCRSGTVELDYFLQAEGVTVFSTRLKNGGENFVPFDEIVDFGDNAKFRIRSRNKVFTLPLRHPEVWQAEPVAGASQVLAAQPPAKEMKDGEEPKGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCC2</accession>
    <name>A0A914HCC2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4 13">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4 13"/>
    <dbReference type="AlphaFoldDB" id="A0A914HCC2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15749.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15749.t1"/>
        <property type="gene ID" value="Gr19_v10_g15749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19504">
        <property type="entry name" value="RecA-like_NSF-SEC18_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054419">
        <property type="entry name" value="NSF_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21964">
        <property type="entry name" value="NSF_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="15">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="251"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="535"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15749.t1"/>
        </source>
    </evidence>
    <sequence length="743" mass="82821" checksum="9922A6AA5C1B2380" modified="2023-02-22" version="1">MIRLKASKLPTTEASLTNKVYVNAGDLDANLTNYIKVVTGPAHHYYFSLANHAGITNGEIGFSLPQRKWTNVTLGQEVQIQPFSFTPGQRIITVISLVIDFQKKPSNPSEPLDTDAMAREFLMQFANMLKRGPGGAGDSSAGKSAMNTTYMLKLVVKRMEGANLNSAPEEISLGPLSPNAVVIFDRPENSQINLIGRSKGKSSHRALINPDWDFQQMGIGGLDKEFSSIFRRAFASRVFPPEFIEQLAMKHVRGILLYGPPGTGKTLIARQIGKMLNAREPKIVNGPEILNKYVGESEANMRKLFADAEEEWRRCGPNSGLHIIIFDEIDAICKQRGSMAGSSTGVHDTVVNQLLTKLDGVEQLNNILVIGMTNRKDMIDEALLRPGRMEVQLEISLPDEYGRVQILKIHTARMREYNKLDTDVNLDKIARRTKNFSGAELEGLVRAAQSSAMNRLVKAGGKVQVDDDAVEKLKVTKEDFDYALENDVKPSFGHSGEELERLLYGGLCVWGDSVTHVLEEGRLLVKETAAPDTRGFVRALLAGLPNSGKSYLAAHIAKDSEFPFIKVCSPEEMVGYSEVAKCAQLRKIFDDAYKSPLSCVIIDNIERLLDYSPIGPRYSNLVLQALLVLLGKRPPRDRRLLVLATTSNEQFLREADLISVFSKVIRVERLHHVKHVVTVLEDTTVFSDEEIKHIEHKLYSDDHKIAIGIKRVLELLDFVKQSERDRNGGRAAIKKREQQQFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDS4</accession>
    <name>A0A914HDS4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDS4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16086.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16086.t1"/>
        <property type="gene ID" value="Gr19_v10_g16086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16086.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="17422" checksum="5011F9C809B46A13" modified="2023-02-22" version="1">MAGQAVSGPTQAIPGAEQAFTGAGQAIHGAGQSIHGAGQSIHGAGQPITGAGQAIHRAGQAIHRAGQAIYRTGQAITGPGKPSTGPGKPSPGPGKPSTGPGKPSPGPGKPSPGPGKPSTGPGKPSPGPGKPSPGPGKPSTGPGKPSPGPGKPSTGPGKPSTGPGKSFRETFNLLLFSIEVCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDY5</accession>
    <name>A0A914HDY5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDY5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16255.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16255.t2"/>
        <property type="gene ID" value="Gr19_v10_g16255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037861373" evidence="3">
        <location>
            <begin position="27"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="104"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16255.t2"/>
        </source>
    </evidence>
    <sequence length="414" mass="47213" checksum="556DF79082163248" modified="2023-02-22" version="1">MQIDLIESWAQLFFLFLSLMLSQNNGKQCKAKQEEEQAKLDQLKHLGEKIKQMELELMKEEAKDVKEELKDMKKGDPYGIMCSIVQLIPYRIISVVLFIFLIFGYYLNKQKENRRKMNRLNPQNRWDSAACHGDLTLSEPDRLIVQFIGENLGCRSVFAERPIPKKDFGIFYYEVTILEQEYGIYIGLATKQMPLAKWVGGHNGSYAYESNGNFWGHAAVKGCFHLGESPYIGGKPKFGVHNVIGCAVDLATRQIIYTKNGQRLETAGLNVDFGADLFPCVTLYGPGTKIEANFGPNFEFNIAIELETEKRGDLWDFAVDDIGGAPDTAHHAVLVYFVCGACGMENRCTFDFFSYGQQSRWGYYRSYYKTKASTGLNYHALDASCEDWARNFYQRVDAKSKEEAAEHARLFYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEY9</accession>
    <name>A0A914HEY9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEY9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16374.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16374.t2"/>
        <property type="gene ID" value="Gr19_v10_g16374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF322">
        <property type="entry name" value="HELICASE MOV-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="234"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="361"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="480"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16374.t2"/>
        </source>
    </evidence>
    <sequence length="840" mass="96562" checksum="C2D9446F3863E302" modified="2023-02-22" version="1">MGIQSVMEYRKQDYYKKLAELKMEKPKKASLDDEAFTELVEFYEKVQTSLMGSEYDPLEKYVEKFRHFVHLFFAEEKLDLESRFKEDINVQYIGHRSASNKAKKGKNASAYAVYKFMLPAQKIEDLILYQTISIDGIKGKITHINRGSSRIEVAFEDKKGQLKFDENIGYCLDIEFNERQYEAFMDSIYLVEKKGRADFVVFPNSSELIPGDEFAKQLIEFKRSARNDPDLMKFDEQQQLAIFSIVNGIHGTVPFVLWGPPGTGKTVTLVECVRQLMQRDDSLRILICTPSNTAADLIARRIMATTKLSRSQIRRYYSLGKNVDERDQELDDIIKMENCSFYGLYDDRFKIDDYDTLLRYNVRLIFTTLACSSYLSKEIQEPDFFSHIFIDEAGQSIEPETLIPITRFATRNTRIVLCGDHQQLGPVVKANFLKRFKSCHFSLMERLMVTMRTECNNLEPEGAQNVYTDGRTFCQLTAKNRKSFCDWKHLPSKNFPIIFHALTKGAEVRQFEGRSYHNEEEVEVVLKYIKMLRETMNIEDEDIGVISPYKQQTLKIRQCLSGSRKITVDSVECYQGSERRVIILTLSRSKQIGFLAEYKRLNTSLTRAKELIIVVASLDFVRNLHPNRSPHNYWRDFVKYCVANNAVLVDGFVGDLDFNDKILAQNLVLIRRCLKETVYSEYVRIERKKRPEMLIQKRRFIDSGSDSSTLESEDEDEGTVSDLSPLSCSSDEEGRRFWAKQIPSGGVARDPKGRGGVNLRGSRGEVAVVNAVNSLMVDNSIDTIEYEDLTGSPGWREEDECGGYDVWKSLPSPKDAYGEAAKQGTSPELQRCSGTMRCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HID0</accession>
    <name>A0A914HID0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTH cro/C1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HID0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17195.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17195.t1"/>
        <property type="gene ID" value="Gr19_v10_g17195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000015">
        <property type="entry name" value="Endothelial differentiation-related factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17195.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18099" checksum="4484FDDEBD9FC437" modified="2023-02-22" version="1">MSKSGRMESDTDPNTVTILRKHQAPQRVLKSDSAINAAKKRGDEVETSKKFFAGANRQHKTDKNTAVLDAETEELHHERVSLNLGKVIQQARQAKEWTQKELATRVNEKMEVIREYENGKAVPNQSILGKMERCLSVKLRGKEIGQPLAPETAAKKAPAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIE8</accession>
    <name>A0A914HIE8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIE8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17818.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17818.t1"/>
        <property type="gene ID" value="Gr19_v10_g17818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17818.t1"/>
        </source>
    </evidence>
    <sequence length="402" mass="43736" checksum="766B2D4876FA3E85" modified="2023-02-22" version="1">MPRPAQSEEQQQQQHHLQHSQRHHAVPGPSSSAPNQRNQTSSSPKIQRHQAVHRRPSSSAAAATGNQRQHSVGNNVAASTMAPPKLIRSSPSPSLPRRHYHDDEQHQQQHRGSVASSVAALATVLAAAPTSLRNNNNSNNNEQSRRSRQRPLAQAVACHPHCLRQSRSVPGSGGGWASQPGSPMLVDRPLPPLFSAGSCSPLPTTNNHQLNHHHHREHVQQYHRRHDAAVLSEPNVSRSAKQQQPPLMPFLRSLRQLKLFKRRSVSELSLVLELLRGGGTIFGGRAENDDGASDGYSSTHGAEDEELELDDNELSSQHHHHRFRHHTASPMPASGVRTASARDRPSHCDNADAPHHAAQSAAPDAAPLSVGALFARRHSAPICARLGEGGKMPKKIPGTKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ23</accession>
    <name>A0A914HJ23_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ23"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17096.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17096.t1"/>
        <property type="gene ID" value="Gr19_v10_g17096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF7">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17096.t1"/>
        </source>
    </evidence>
    <sequence length="604" mass="68890" checksum="F41FA1082B10EAA5" modified="2023-02-22" version="1">MFGYASRVWCRRQQKIRFLVAAKMELTAEIGRQNKSIHLLLPFWPSSPPAFCSNQQNPSLDSARSRKIQAWIQPGPGKSKPGFSQVQLPVGWPVWKTNKVSGECAPSLRLAVVAKGRPRDFSRHIEFKIWGVVHQLIMSFHCDGSCSAATARTPLLPRAVPASPCTARTNSGCLTQTGIQSLKKRVEESGMSSELVEPFEMDVRSDDSVAKAFEFVENKLGPVKGLHALVNNAGISWDDWLVPKDYDDVWQVNALGTIRVTHAFKRLVKREKESRIVIMASSCGRVALPTLGPYNVSKFAVEAYADTIRTELIMFNVKVSVIEPGFFRTPITNLERSNAILDKIWARTPESVKQEYGPNFFKFCKRYLLFFLDPSRLNPHTEMVVDAYWHAISSAWPRRRCQVGLDMHCLYWPVSLNSHSSRFPSMVVHVKGSIIVFPTKTLLICAIFFRIEEAFVRRFNCQKAQKFFPPATIGGAIALRLLANGLAVSALRLTSKSFILPTNPRSKEDQEEDDHRRGKEREGLCFARNERAEKKERCNVKRLANEERRRKRGGGRKGGGGREEEEGREEEEGREEEEERRRKEERRRKEGRRGREEEEEWAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJR6</accession>
    <name>A0A914HJR6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HJR6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17524.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17524.t1"/>
        <property type="gene ID" value="Gr19_v10_g17524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF2">
        <property type="entry name" value="ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="113"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17524.t1"/>
        </source>
    </evidence>
    <sequence length="425" mass="50144" checksum="3828BBD791CD8416" modified="2023-02-22" version="1">MDNEQFKSGKNKPPGSRSKWSQATTAERIIWISAIPFRTLLCLMNITVFFVAYFGFMLPVLWAKPLWPRFYWFYEGKLYMWMQAFIAYWGYTADYDVYEYGEDIRRFAEKDRVLVIINHQSTADVPTLFTILQNKGVATRKTIWLMDVMFRWTPFGIIGRMHGDYFIQQGKATRDKELIRLKEHLRKVFWDRDRRWVVLFPEGGFFYKRKETSQKYARENGFPYLEHCTLPRMGAIKAVLEEIGPREEENGLARSASTSSKMKLIKDTVGAIREKKYVKDTRPPIQYVLDVTIAYPNGQPLSIGTLCFGTREQCDIAVHYRMFDAEQVPFHNEIALRDWLYNLYAEKDLLLDNYYKTGEFTPGEEGERIVFDWLRIVGQWAFWITAFVLQVKFAIWAVRTVFYTVFGFLCIIWACRITALFGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK58</accession>
    <name>A0A914HK58_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK58"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g207.t1">
        <property type="protein sequence ID" value="Gr19_v10_g207.t1"/>
        <property type="gene ID" value="Gr19_v10_g207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009545">
        <property type="entry name" value="Claudin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06653">
        <property type="entry name" value="Claudin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="196"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g207.t1"/>
        </source>
    </evidence>
    <sequence length="539" mass="59395" checksum="692F9DF35E702206" modified="2023-02-22" version="1">MATVIFLRPLLLTLVLFATILTGVALFTPSWRGEIGLISTNCSGGGCGPWWDNQPGWYQTVIILVILAFVVELVAVTWAALSWVGFCPTALNFPLGFLCAVAAALLIASITTFAAGNPHEIVGMSSHAHLGYSYWLAVLSAILMQNSLIGHFATSSFKLVSSLISPTRCPVPPPQQQQERRERVVLALQTLVAGRWTIERKVAAGPFGDVYLCSDGQAVQGTLRTEIIDDQTSFLVPEALLLRSLADIQADEGTRHFCRCLDIGVDQKTNATTGQLVNFNYTVTSLVGRRVNLLVPDGVSFSPGTAISMAIQLLEAIKTLHSIGYVHRDIRPGNLNIGRPQLNEQRLLYLLDLGMARKYPIQGPAGEAPIPEPPTPLNYRGTPMFMPVSAHRNQAYDRKDDVESWMYVLIKFYRGALPWSGITTEREMGPAKSLRTQATVNIERRTRAKLLEGCPAEFAEILTHIDQLQRYDRPNYELITTLLRNCLENNGFPERPYDWEIARQAPSGASAQRPARSTSSTQRPARGRGGRARTGSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKH2</accession>
    <name>A0A914HKH2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2311.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2311.t2"/>
        <property type="gene ID" value="Gr19_v10_g2311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037066709" description="polynucleotide adenylyltransferase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="12">
        <location>
            <begin position="1130"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="588"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2311.t2"/>
        </source>
    </evidence>
    <sequence length="1374" mass="157521" checksum="4C950D3394485DCF" modified="2023-02-22" version="1">MMKIQFLLILHLQFDQIIAAPGTGIAKIIAAPGKGIETICSWYNTFRFVYYPINGIQHILLDNLYMDYFLDNSATDQRIIMQKIAIYTHIYMMRWTIEQNVGKLCKMRAFRPTDGYNAEAGAGGTSNNAGQSAYDKMHQKFTKWGQKCKMFTFQPVADGHADGDGAGGTSNKTGQNAYEWLCQEMKIIFSLIDADDKTPEAIGDLMHFPSSLTMCYFLKFKFELSHMLSATNFGIFPNENVSCKSVENIRQSVEMNLEPIREWMLSDLVHFFKRRPKLVKYFDKLHKRNNESEIVENRQKFVALFGIARTALLYDVHFENFGFFALINEKNNSNTLLYKEFFKQNNKLGKWRTKILLDKYLYSEWFITFYNNEMKAALEGGQRGEKLHTMAILADLHCFWDCFSNDFWLNEKNIRQAIGQFVKKNGGKMSKLKQPFLVQCQPSDWVNCQQNETDLPTLWENGPEDVSLFRALTICTKEIINEQKVNNKQAKSVEIDDNFLSITNFKFLQCVEKGLKNNARRDNILSKLHFEKIEELLEYEHYAGFIGFKTLLSENKRSLKELLDSEGFKKVDELLKKNFEYFSPGKKKAKFGTKGRSNSGKSFELRRVSSEGQLNASTRRRVSSEGQLIDNTRGQLIDSPSPPRGQLSDSSRRRLVDIPRGPSERQLGNSPSPKGQIEFDPSSPKRQLDFSSPTYYTCVTMLKQIGIEKFSDLLKDFLLGNFYKKYLENKFDEKCVVYLHISMFVRTIEAKLKTKTTNFEKNAKWKSFKDKTFVEEPQFLAEKLFVVQSNLDELSAFGTSTSTDCLEKAMEMLNNVKMRRVGKDIEDDQFENILPLINDQNDDDDDVIRITQFGSYKMETFKNVLIQLHNHVVAFLCAKKFAEIPSENEQNATLLNLEKLNFIFNAREMLLKKVGAMNIMLTQQQIGNPIICESSQYNLIRTNPANRQNDDHLSNGIVQFITLFCAGEEKNSMIDQIKWQIALALKKWVQKVANFEQPLLLTSGSHLMGSNLDSSDLDLLCVVPDQINLFTFYGENDTTLYSTLRKELFGAKLSWIAGKVPLIQIKFGQIELDLLLVPVPIKYLTGRTAAAKLESDQVIKDIGNVKGIYSLAGYRSGKFQLSLVNDKQLFAYFLKSIKVWAKNRLIYSGIFGYFNGATLSVMVTKICALFPFAPLAYLLYQFFQIYSKWNWPVDPVLLDKLSTDSLNVLVNGWPPKFGENSMTVITPKFPEQNAAFNVNKFTLRTIVEEINSANQILSENGQKWAQIFEEVKYAEKFAHFAIILCADVDAQRHATNCGFYRSKIRRNLFEWATATNVLPMLAHYQIIPQSEEKTICNISNFVANCTFWMSSSYTNAEKLSNTLNELHASTAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLM0</accession>
    <name>A0A914HLM0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plasma membrane proteolipid 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HLM0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2633.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2633.t1"/>
        <property type="gene ID" value="Gr19_v10_g2633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF16">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN C04G6.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2633.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11712" checksum="C115C46C46BF4FBB" modified="2023-02-22" version="1">MTTTGNGPCQECPCNAYREDGIVDDNDRCWYCWCGHLLQVHALIPKTMVEVQQLIELIFCILLPPVAILLHGGLDILHLILNIVLCILGYVPGVIHALWYCFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLW2</accession>
    <name>A0A914HLW2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914HLW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2551.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2551.t1"/>
        <property type="gene ID" value="Gr19_v10_g2551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036988384" description="Glutathione synthetase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="16">
        <location>
            <begin position="252"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2551.t1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56624" checksum="8B57AC418243FC03" modified="2023-02-22" version="1">MNAMLAQLFGIIFILTNFGAIVAHPVDKENEAEASTNNKVDKVTRNYVEALVTDEGHLNSMRSFAVEWAHNNALIFRTKEHPTKSDVSTIAPSSLFPSPFPRQPFEQALAVQKAMNELYFRIGTDFEFLQEAYKDVIEADEHFRNMMDMLKSVHEEGIKQPITVIFQRADYMLNVIKGQNGEEPTYEIKQLEVNCGSIAGTSLDRHATELNHVMLKKAGFHAAPEDLPENWPDKAQIESIKMAWELYGNPDAIVVIMITNISQTVFDARFFETELDRISDGKIKVARVTLSGCEIRCSLDENSNLLLDGREVAVLNSRYSALGFMPGVHVMNVRKMIERSQAIKIPSAFVGFSCSKKVQQLLAEQGMVERFFPNENDAETDAIANPNNYVLKTNMECGECNYFDEQLANKLKEITPAKRPYYVLMQKLRPMPIKNIMIHPFTPSKIDTMVSELGVYGVLLGNMLTKEVKHNVQQGHLLKTKLETANEGGITKGTAVHDSPILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HM34</accession>
    <name>A0A914HM34_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HM34"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2609.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2609.t1"/>
        <property type="gene ID" value="Gr19_v10_g2609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2609.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13311" checksum="A639FB71060457C2" modified="2023-02-22" version="1">MRQKDFVQMDCGPHVPRCLNVECEADDQQIVIKYCGKNCSQAKCANGKSANVKECRACDGDLCNSAFGPLQTNALTDYSYNRETMPKEQYMCQLCANHGQYNQPKKGHKLKCPNRHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMD4</accession>
    <name>A0A914HMD4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMD4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2672.t2">
        <property type="protein sequence ID" value="Gr19_v10_g2672.t2"/>
        <property type="gene ID" value="Gr19_v10_g2672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2672.t2"/>
        </source>
    </evidence>
    <sequence length="393" mass="40734" checksum="8A5D69529BD13FDB" modified="2023-02-22" version="1">MENVRSAFIFSICRLLPFTFLLFNNTIRWGVVKGQAFLSTNQCPFGSTPDGSCPLGVCFSRNERCYNGRCCRSTGQGMYNGGYYNQCPAGMYKDGSCAYVNFCFDPKERCIQGVCCQPSTTNPVYPPTNPNPTYPMYPNYPNYYATNPTYPTYPNTYPMYPTNSYPQYPSYTYPTYGGYSPGYGSFAGYGMYNNNPQYPIIDNYGDGISGGYAGIMGMTGCRDYYYECSSYTAYCMLESIAEACMGSCGMCGSSSSAGLLGGGGYGNGMLGGGYGYSNGMLGGGGYGNGMLGGGYGYGSGILGAGYGNGMLGAGYGNGILGGYGNGMLGGGYGYSNGMLGAGYGSGILGAGYGNGMLGAGYGNGILGGYGNGMLGGGYGTGLLGGGYGSGFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMI0</accession>
    <name>A0A914HMI0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMI0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1948.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1948.t1"/>
        <property type="gene ID" value="Gr19_v10_g1948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1948.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32744" checksum="35DF2B29DE22AA47" modified="2023-02-22" version="1">MLESVNKFPIEGIDELLKRRLQEPLENAISNCKKLEDKVKASGLEDNKKYLESLLSKIRSVAERIGEELNTFMFEPRSFMGIRNWRPSLSTGLGILKNELSAKIAGFAKQPSHIDGDGFMAFSRNFKSEWNQIEQQMDQVSNRDIASTMERYRTELNDLAESAMEKTASLTDLITLKLDQLVTKCHAAKPEGPMIATKEKESQHQQQPTDAFLNEEPQFEAKKNEINAKKDIISDIGMFDGAAYKVLVRFEHEELDKTDFSCAELEKAVEKDKEMVLQAYQVKNIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HMP3</accession>
    <name>A0A914HMP3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HMP3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2004.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2004.t1"/>
        <property type="gene ID" value="Gr19_v10_g2004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2004.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13969" checksum="D48594F9AFD7C762" modified="2023-02-22" version="1">MLLMKRCFVHLQKLKLKQYLSNMLKQYLSNMLKQYLSNMLKQYLSNMLKQYLSNMLKQYLSNMLKQYLSNMLKQCRRCSGLMLSTLHNNRPSYRPSSTRSEDDGAGCNNRSMHSNLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNB8</accession>
    <name>A0A914HNB8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HNB8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2183.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2183.t1"/>
        <property type="gene ID" value="Gr19_v10_g2183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2183.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39254" checksum="8074FCA18F655145" modified="2023-02-22" version="1">MYRQLLQHNHLQIYCIRGDWCDFDCGRFHRRKLQNNGTNSEVSANVDAIEKAALLNHGNRQNEPPKLTVVATSLPLQGTINPSADRALSLALPASPFPYSNTPSPAGSLATRQNGPLSVSVTLDDIIASARRKISEDYTDIQLPSPVFMDEQDKTGWDKRAGKKLLFHYSSLDVPAMESMDVPTESFLAHKYEDVDSEAELAIQEEPPRFMNDEEAEDLEEMIKAAQPPTDAFSNPIMLRDSDSLTTRKKTKRGGKHHAAATVLRQQSKSRLLKLGEMLDSRTSSVNCTNDDFDDGADNSSIADGTESLAELSAMVAKSTAHSGATSPSNILQFIEEQKHRVANTGAEVEAVAEEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP56</accession>
    <name>A0A914HP56_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HP56"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3110.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3110.t1"/>
        <property type="gene ID" value="Gr19_v10_g3110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="334"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3110.t1"/>
        </source>
    </evidence>
    <sequence length="552" mass="62739" checksum="CF2EC81004C6B609" modified="2023-02-22" version="1">MPYYESDVVFLISDLDNPRVINSNSRFYSNFHFFPSSSSPIVRNIDESAKMEEFQKQQQHNIDESAEMEQLNMDYLQSDQKASLLKRQQKTDQKALGASIDQVTSQLKGERSANMVEEYQKQQNIDALIEAQKGNVEIGGKMGKIGNLVAILTPAGQWRRYDPYRIAGLAVAIVLLIFGIYALHQFSNKFAEKEELHQMKEELKNTKESFDKKLEEQMEESFAKLKLENKALRAELEKYQKQQQLTIDDLTEKLTVSIDQLSLKHQGELEKLSNAHKKLMEKFALLNSVQAMVIAELEGHKRSNANKFAEIEQKNALQQETVVSLEKYQKEQQLNIVHLQKTVVTLRQFGLIPQNRWDSAACHDKLALSEPNRLVVQYNGEDFGWWSSVRAEKPMPENPYFEVKILEKTRGYFSIGLATKQMPLDKFAGNHKGTYGYGNSGIFWGHEFEGCSHNGDGRPYIDGKPKFGVGDVVGCGVNLATRQIIYTLNGKRLDTVNLFVDSVADLFPCVTYGLYTANLFVAFAVDLFPCVSLAKPGIKIEANFGPDFEHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQH2</accession>
    <name>A0A914HQH2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQH2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2767.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2767.t1"/>
        <property type="gene ID" value="Gr19_v10_g2767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2767.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21991" checksum="B5406FF03E73E7F7" modified="2023-02-22" version="1">MHFVVKNSICSIIKFCNSFSRFHSGVIVAKMAENIEEILAEIDEEEIEEFQRFFDMFDKSRNGYIMATQLASILDVMEQDYDEKTLRKLIRKFDADGSGKLEFDEFCALVYTVGNSVDKETLRNELKDAFRLFDKEGNGYISTQTLKELLHEIAPDLSDNELDSAVDEIDEDGSGKIEFEEFWELMAGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRA1</accession>
    <name>A0A914HRA1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRA1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g351.t1">
        <property type="protein sequence ID" value="Gr19_v10_g351.t1"/>
        <property type="gene ID" value="Gr19_v10_g351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g351.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33034" checksum="0FBA14BC36DF96C0" modified="2023-02-22" version="1">MAASLPPLLLQRLKKRGIVPAKNEDEEVFAENYDQDDGSKSEFSREKYRGGAPGCPNKHIPIHVCTDFCFDHWQEGYPENRLSEKYLEQRKKMLRNYPLPKDWVEIYDAGVRRHYYWNQMTDEVCWLSPKHPKAVISEAAAKIARNTWNTSKIEHDESDRNGRKGGRERDEREGSDRKGRERYRGKRTKDYELALPDSDEEGGRRPVVELTDRDRLKRAKRRGVDPMDPSAYGDAPEGGWTSGLREDQEVKTGVDVTASGPLFQQRPYPAPGAILRKQNPDLYKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSA6</accession>
    <name>A0A914HSA6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSA6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3765.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3765.t1"/>
        <property type="gene ID" value="Gr19_v10_g3765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037862913" evidence="3">
        <location>
            <begin position="21"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3765.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40832" checksum="41765B030B6CFBA0" modified="2023-02-22" version="1">MIKVYSLAFCVVLLIGTVFADFKKCSDALAFDGPGNNVLLKLFKESQLEDEELKQFVCDLGEHEIVIGAAFDDQAQGLPPTISPSLKEEFEFLKKSELVDKPAAELLHKLHKSISALKHSINEGITVKNSVLKAIKSELVQTLRLLADRWQIPADEIVPMEKKMGQESLLRELAKLWNEYKRQNWKNDQNSNESNYGKGQHEKRMLQLMMDLSSDGSGGLPDLKSAKKRQQRRRRKKRGNTQSYIAIAAVVVVAVILTLGLCACLQRCQYSDGHGNALESGRPRGQRSGTMPYRGHQSMDNYGGHRSSTYGHGGNRNTRRSNHRENRPSNYPNNQHLGQPPSPGRFVPLPPGYEEEDEHGCTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSC1</accession>
    <name>A0A914HSC1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HSC1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3303.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3303.t1"/>
        <property type="gene ID" value="Gr19_v10_g3303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3303.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23330" checksum="50DDBD8C1465AC78" modified="2023-02-22" version="1">MKEFWNLILVSFFATNSLDKVEPVQLEETPLKIIDEIFGEGWWDNEKDEEWNKLTLEHNFHHQIDRQNTQIGQIEPNSTDQNPPLTDYDHSGQIEPNSTDQIGQIEPNSTDQNPPLTEWKRKLGQSTPNKYSDSEQKELMKIYYEIKDKNPKISDGDIAKMLKIGTTSLVRWKKQFKRQKFLPNSVNGNSVEENAAANVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTI3</accession>
    <name>A0A914HTI3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTI3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3623.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3623.t1"/>
        <property type="gene ID" value="Gr19_v10_g3623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3623.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29834" checksum="670119C64FD95F9D" modified="2023-02-22" version="1">MLLKTKAKCIFFRHCICKVVHRVRGQNDEIGIKTANNQSSSWRANDKLCARHGKVVIGDLLLLNQTETWKRYLAQAMKETMVVGPHYLDMETSTMRKAYSTGMDDPEQLQQKGMNLLRQNKRQDTPSVTSQFNCYLDSQSRMAQGLGGHVSHCCGNSAHDMGWETLNGITHLCSAPYNRCRTDKPKGKSSAKMFLQLKFRTTFDLLRAKRRPIVVRDEEMEKRFNRRHGAKPRPFDVDAKVFGEKDCPNPGEPTTSTHGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTU7</accession>
    <name>A0A914HTU7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3917.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3917.t2"/>
        <property type="gene ID" value="Gr19_v10_g3917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1770.10">
        <property type="entry name" value="TPR 1 domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="564"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="894"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3917.t2"/>
        </source>
    </evidence>
    <sequence length="1323" mass="151575" checksum="7B7FCC07537179AB" modified="2023-02-22" version="1">MSKRPSNFSIDDILAPKKPRHGFLVNQLLGVVHMLDSVQHGEGASTSTKKLPKDYVKKLHSNIEHVVKFHYVKLKTAFSIQDVPADPEGMLAGVFQYCIDEAKQDSRERGIEPTHLGCMISSPLLTGGDIPVPVRQITDNTINTILNLFNKVAQSKQQDNVSLFGEPFTITITTVDRNGLPSKRKLKGGARRKLAPIRHKVHDQCLIKIRNDEDSYCLFYALQATKVDKTCSWPRWKFLDYLHSRHGQRGQLQQDTLRLMQQIGVPLSLNAYDADTYVPRVVDYWNNAQQQNRFAVFIFGSTGQYKPLYKYIDDRYDTPILLYFDNSHFDGVQNQSGLFGRRYCLECEVPYRRAPEHNKSCKARCRFCGRAGPSFPCAPYDNFFKHCATCNKNFKNNDCYHHHVRSAFCKRSKKCKDCGVIWDVPNNTQHGRDGHVCGERFCQLCNNYHASRGCFILPLVPKDLEDYRIIAFDLETMQHLSVTPQQPERKNHEPNFISAKVACPNCITSGKWKTGTTGCLVCGQHRTVAFCQRRFTDTQVDKQVVVDNPMEAFVDWLINDLPVKYDTYAYSHFGGRFDMVLVFRQLFKIGFNPDMLRKGNKMYEMRVRMKKGNNPNIVFRDSFNLMPSALAALVPQFGLDVEDKPFFPHLANCPANYGKEIFPTPEDYLANGMMPEKRRQFDKWFEQHRQQPFLLDEALAAYCTNDVQILMAALIAFRREFLDVSKRHDYIPGVDDRLNHDGIDVLKHCMTIASACMKHYRMNHLQIDHLAIVPERGYDNAQNQSLLALRFFHWYAEEHNVLIQTAHSPAGEKKVAQYSLDGWIESEQRAIEVNGCAWHGCIKCYPDDNQVLPNGKSAGQRVDVFWECEIQRMLDQSREMRKIFDDYVDDGPLEIRTAFTGGRTGPAKLFHKAGEGEKISYYDFTSLYPFINFVTRYPIGHPTVHILNEDVQWTTSTDNPYDLALLKVWVVPPRRCDVPVLPVKVDDRLCFPLCIKCAREYPTGGVDSDYHCQHDDKQRGWVSTCTSLELNAALDEGYKVTKVFRVLEYEQSDDQLFRPYIAEFMAQKIHASGFDANIKGNADLEAEFVRECDEQFGISIDAKKMVPNKGKRSLAKLCLNNLWGRFALRNFGLSQTLITDDPSVLGEHLDNRAVDVTAIDELDEDHLLISYETRKEWVEEHACSNIVVSLWTTSAARLLLLKAMQKVVRAPGSTLLYTDTDSLIFVHPKDNCPLEVGPHLGQFTDEYPLHDIQEFCSGGAKQLKRKEADADNEYVLKVRGITLNFDVTQNQGLRYQTFKTQVMEYAKTDLMSVKVLSEPTLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVJ4</accession>
    <name>A0A914HVJ4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVJ4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4174.t2">
        <property type="protein sequence ID" value="Gr19_v10_g4174.t2"/>
        <property type="gene ID" value="Gr19_v10_g4174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4174.t2"/>
        </source>
    </evidence>
    <sequence length="173" mass="19331" checksum="571D4FE8FACB8C1F" modified="2023-02-22" version="1">MLTEKKMLKKKRKMMTKNMAITRAMFPKRPMIMGKVGKSWNSSNCVRTTATNWRERNSAEIIGEDGKFTEGKFEEEESGINVGTSRQKSNGKPLPTAVIVICMSTVGFVMLAVFVGMCVAKKRQIRCFGDVLNTEHIKEALAEAVRKSVSEHQSVMINVLIGKTNFREGPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWI7</accession>
    <name>A0A914HWI7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWI7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5136.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5136.t1"/>
        <property type="gene ID" value="Gr19_v10_g5136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.20">
        <property type="entry name" value="Mitochondrial ribosomal protein L55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018615">
        <property type="entry name" value="Ribosomal_mL55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044884">
        <property type="entry name" value="Ribosomal_mL55_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L55, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09776">
        <property type="entry name" value="Mitoc_L55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5136.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="11135" checksum="E5A0A1375310F428" modified="2023-02-22" version="1">MTAWRACLGKIRRKEFVRLYKVRILRSDGSLIFGRCDEPREILKLPADLRTLSDDEQRMRIAERKTAVRKVVEDTFDDTFDFHKYVSEWKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWQ1</accession>
    <name>A0A914HWQ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWQ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g536.t2">
        <property type="protein sequence ID" value="Gr19_v10_g536.t2"/>
        <property type="gene ID" value="Gr19_v10_g536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g536.t2"/>
        </source>
    </evidence>
    <sequence length="321" mass="36343" checksum="D48E61B31D1E77B3" modified="2023-02-22" version="1">MDVYATYVTQQNGMKQQQPQPNAHYATTMPLLQQTARVFVGPGQQKEAQLIGLGLRKLRSYEKDDLERAKRYAMDQSVKYVMLKQREAHQQQNGLHKCSPIALSIMSRVYIGSINFDIGEEHLRQVFAPYGPIKLINMCRDPSTGNHKGFAFVEYEVPEAAQLAQEHMNGKMMGGRTIKVSPVTRPQNMPQAQSIIDMIVAEARKFNRVYVASVHPDLLEHDLRSVFEAFGEIVKCQLAKDPSGKHRSFGYIEFKTAQAAKEAVEGMNGFNFGGQCLHHAEPKRQRFAGRRCDGCRRNHREDPGTGSCEDSPRLFKPFAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWV7</accession>
    <name>A0A914HWV7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HWV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g489.t1">
        <property type="protein sequence ID" value="Gr19_v10_g489.t1"/>
        <property type="gene ID" value="Gr19_v10_g489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="103"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g489.t1"/>
        </source>
    </evidence>
    <sequence length="527" mass="59285" checksum="7148EEADBB835A51" modified="2023-02-22" version="1">MIDMLAANNGKVTNLRRVTYLVMDEADRMFDMGFEPQVMKIINNIRPDRQTVLFSATFPKQMEALARKVLERPVEIQVGGRSVVCKDVEQHAFVLEEHQKFLKLLELLGQYWEHGNVLVFVEKQEKADDLVSQLMGAGYNCAPLHGGIDQDDRDFTILDFKTGRLKLMVATSVAARGLDVKKLILVVNYDAPNHYEDYVHRVGRTGRAGNKGWAYTFILTVGQEKIAGEVCRAFETAGATPPDDLKKTWDDYKLRMAAEGVEVYAGGGGYSGSGYRYDDTEDESELNKRKMTKLVYGLESGMEDDVANIDSQLESMMKSSKRVVHRRAGASFRGGRADPSSGKKVEAARAVAERIAAEKLVQPSTQLEKDATQLTAEAIMRGTEAAPLTLSGISLAKQKAIELNEKLNYLPSENPAQETEQQVQYFEEELEINEFPQMLRFRVCSRDSIAQIQEFADVGISVKGTHYPPGKEPKPGQDRKLYLFLEARDELSLRRAKEEIVRIMRETLRQMTATGMNRQVGGRYKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXC3</accession>
    <name>A0A914HXC3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HXC3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5529.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5529.t1"/>
        <property type="gene ID" value="Gr19_v10_g5529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037041674" evidence="2">
        <location>
            <begin position="21"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5529.t1"/>
        </source>
    </evidence>
    <sequence length="519" mass="56765" checksum="EAC21EADD0D58478" modified="2023-02-22" version="1">MVRNLCLLLLTTHCLSGLIAVNAASDDELEKKEPANEEAHSSIDTESKQEDQQKAASIDTEPKQEDQQKAASIDTEPKQEDQQKAASIDTESKQEDQQKAASIDTESKQEDQQKAAFPYPQVPTSSTQKRQPKPLKSPNFEYNDAFPTSSSSAEGDGDEEYVATESEAESNSAESLVKSSSSGEELDKSPNNKDSDEWQKKKVAPTKSKARKSSLAPGPSKGPNRSGKKQSSDEWLNDEDSDKSTNDEDSDEWQKKKVAPTKSKARKSSLAPGPSKGPNRSGKKQSSDEWLNDEDSDEWQKKKVAPTKSNARKSSLAPGPSKGPNRSGKKQSSDEWLNDEDSDKSTNDEDSDEWFMNNVAPTKSKARKSPLALGPSKGPNKSGKKPNQPRGKTMITLSSSSSDSDQQQKGKATIQSKKGLAHKASIQQQKQGGPKVILPKTTSQRKDKSAATSRSPSAGEKNLTTKWEKDSDEDNTSEDNKRTTQPQNKKRSGKKVESKNDKAGGTKATPTQKRQKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ11</accession>
    <name>A0A914HZ11_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DIS3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ11"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5339.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5339.t1"/>
        <property type="gene ID" value="Gr19_v10_g5339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNB" evidence="14">
        <location>
            <begin position="476"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5339.t1"/>
        </source>
    </evidence>
    <sequence length="963" mass="109959" checksum="23DCC37551E45B9E" modified="2023-02-22" version="1">MELNVKQSGIEKRVFRTTFYKTRSGKFNKRVHELYLRNDLPCGLSACSHCHYEGQMKPILFEENAIACKSAPFRHCLLIDGPTILRFIDVLDNHEIFRNLIILQSVWAYVKKMNSAIYKRMNAIYTENAGQMFVFLNEFVSRTFVESGNTTVPELFQEKCLLKSAIFFLDHWKALGIRPLLLCSSDETKVRLGKSFENCLTLLDYARGIGCETSLLERLEDLCRKESRGKALYPEYWTQDQLLDGILKGTLKKGKFKISSENYLEAFIEFELEDQWFVKGTKCMNRAVHGDVVVAELLPEEEWSAPESVIRLRDADEGQTVDIAPEEEEEQSTEESEKSTAKKARKDVLPSARIVGILRRNWRHYCGVLLHSNMPGGRQFLFAPTERLIPRIRIETSHFEQLKGKKILVQIDTWPQDSHYPKGHYVRVIGDEGDRKTEDEVILLEHDIPYEDFPPSVMACLPKIPWSPFPMSPDQREDLTHIDICSVDPEGCTDIDDALHCIEICAGKFEVGVHIADVTHFVRPGSAMDTSAAERSTTVYLCGRRIDMLPELLSSNLCSLREGQLRYAFSVIWTLDAEANIEKVRFCKSLIRSRAALTYQKAQEMVDGTKIHRDNISLSLRNLLFLSRQLKSRRRTMGALELASSEIRFDVDRETGTPLKVQEKQHLETMSMVEEFMLLANISVAEKILSAYPDCAILRRHPTPGRLSFKPLIGSCGFKLNVDTSKELAKSLDEVEQQCRQSGGRHNPMVARMLRMLATRCMTQAVYFAAGTVSRDHYLHYGLAVNVYTHFTSPIRRYADVMVHRLLAALLEIEEMHPNMLDRKRLIRQAENMNRRHRHAQYASRASVLLNTFLMVKECPEKSLAAIVIGISSNGIKVMVPKFGLESVIYLNRGGDGTIRQNVTWTQQRMAEFCASNGISLFREVKVSVAVVEHKDQRKRIDLKLVDPVVDGLSIVMDCETNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ41</accession>
    <name>A0A914HZ41_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ41"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5360.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5360.t2"/>
        <property type="gene ID" value="Gr19_v10_g5360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF58">
        <property type="entry name" value="BESTROPHIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5360.t2"/>
        </source>
    </evidence>
    <sequence length="378" mass="43790" checksum="36752DD2813925E0" modified="2023-02-22" version="1">MADIQSTKHFGTFFRVIFRWRGSVWKCVSADLVFWLIAYYVVMAVYRFLLSPSGQNAFESISNYANKTDQYIPLSLLLGFFVKVVLDRWQGMFGHIGFIDKVAHTVSAVIRGADPETVTQRRNIVRYLCLVQLLVLRDISVPVRKRFPSLQSIIDAGILHAHELRLINAASNVQSTTNDFGIHWLPFHWACELCQRARQTGRISGDPLLAFLFSQLMQYRDHLQKLLNYDWVPIPVAYPQVVFCAVRFYFLVCLFSRQSLISDERLHTDAKPFFKAYLPLMTIVQFVFYMGWVKVAEELLNPLGEDDDDFETLFVLERNLHVSIALADQHHDQVPEQYRDTLDKRHDEWGTKTTLSMIGNPSLRMEPKSASVKKNKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZF7</accession>
    <name>A0A914HZF7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZF7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5903.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5903.t2"/>
        <property type="gene ID" value="Gr19_v10_g5903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5903.t2"/>
        </source>
    </evidence>
    <sequence length="126" mass="14223" checksum="1A0A406842C98BBC" modified="2023-02-22" version="1">MDADCRQRYLVTAVFSLSAARHNSSVDQEIPQWTVSAVRCASSRNSSEKSGNANVEGSIVKEEGIVEHRTEQFRPMARQKKKAQSNQSSRQFSKQNNNYNDSSTTVTQDAKVKKKLDDASIEQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I009</accession>
    <name>A0A914I009_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I009"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5641.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5641.t1"/>
        <property type="gene ID" value="Gr19_v10_g5641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5641.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7698" checksum="E89C527115712DD1" modified="2023-02-22" version="1">MVVNHLSLYKTPTLSTPIHKNRMHGAQPFGTFGKIEVQVFNQNLIVQCKGQPVEEMTHIFNYKSLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0A0</accession>
    <name>A0A914I0A0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0A0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5680.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5680.t1"/>
        <property type="gene ID" value="Gr19_v10_g5680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5680.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30656" checksum="38C9BF66C5F92DA4" modified="2023-02-22" version="1">MGSPLVVRVTIFIFFILTIEGFHVMRDNLTVADEAVATTLNQSFFDQFEAPNEQRVIIEQEKAIEYLKIIHEILEVTDYAVNFTGLEEQIENMINNINKKLLENRANQQQIANDFERNFGKRMCRLTMFVSLAEFVSSEMKKILKQYGKSLLPRACARILRAFQRTSASIADPARTPFVERAWKAQLLGVYAQIKVNERWFEKIFDFMDIAKIIMTETRALLNDQPYIQSPEIKRQLNELLNREHLHNFVATKIELESNCTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I135</accession>
    <name>A0A914I135_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I135"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5636.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5636.t1"/>
        <property type="gene ID" value="Gr19_v10_g5636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037067490" evidence="1">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5636.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="29479" checksum="F017E6FE6A791B58" modified="2023-02-22" version="1">MLLNSIILFTLLLTANAYELFFKNLSMLGEAEENFSCTLKAFKETEENKCGGLGELDTGGAPNEGLDWAKDKLCLKVSCDGEPTHETATKIAIRLQQCQLIRLEKDGGNTTRPIVLIDANGCAAVGKGNGRRPSLIGPLNYSREDVAVEMHGWTFASGDGAAAPDKATLSCDVQVCSDPCDSNCLEKISLEKCNFTEFVEEKRADELCSANHENGAVHSGISYYLVLGTGTARPGTLVRSTDDVGSQAFANHLMALINGPAARISHVTKAMANFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2Y7</accession>
    <name>A0A914I2Y7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2Y7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6379.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6379.t1"/>
        <property type="gene ID" value="Gr19_v10_g6379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6379.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22505" checksum="12FD544E0C4805F1" modified="2023-02-22" version="1">MEPLRSFWANLLYLKFPQNTSKLVDALRGHVLTLAQQVYGCYVIRKALESITNELSAKVSLLFVQEYGSRVIQHVIEHGLPEDRGRIVRSLQGGIMKYAQDKFGSPVISKCLACGTADQKRALFDTVCVGGPGTLQNARQLMADEFGTFVIQKFFECGTEDQKARLVDALRGHALELALHVNGSHVIETALKSITNQCPVGTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I345</accession>
    <name>A0A914I345_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I345"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6388.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6388.t1"/>
        <property type="gene ID" value="Gr19_v10_g6388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF369">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6388.t1"/>
        </source>
    </evidence>
    <sequence length="520" mass="59655" checksum="C679D9A2FA64EE43" modified="2023-02-22" version="1">MFLGLCFLNIFVIFFWNFVWKRRKLPPGPTPLPLIGNLHQLAHFLEHGGAGAYIHYAKLYGPVYTIWLGESSGRHFFRITEILTATHGIFGITKTHGEEWLFLRRNVLSTLRDLGMGRNRMSQEMLIGLRKMSAKIRAETKINGPNRIDLIKPINELVGSSISLLLYGHSLEEEHLEEYWIVKETMKNMLKMLPWTTTQIVTSSPLFWLRHFPPFAAIFNQFDKSMSSTFEAIDKEIGTILKRREWEQQNGVTSGDAGESNSLVDNFLDSIFKVEERKKRGDVPFKQDKYFHMNTLRSLCFDFFLAANESSGNTLSFMLIYMILDQQIQSKLHNELKNYATDKGLLPKCEDEAEDHSDWLCSAIGLEHRPFLPYTNAVINETMRLVNLIPFNFGHMALEDMQIGNFVVERGTPIIPQVSSVLFDEKLYPEPYHFLPERFLDDKGQLMKSDELIAFGIGKRQCAGEGLARMSLFLLTANFFLAYKVLPSDPLNPPSPAKVAALTVYSEDFTCRVVPYLDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I394</accession>
    <name>A0A914I394_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I394"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6474.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6474.t1"/>
        <property type="gene ID" value="Gr19_v10_g6474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6474.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="20844" checksum="F47D45D9A19ECB9A" modified="2023-02-22" version="1">MSASSSQPNDQPTSSHADQKQLVVASGTSVEAANRSVVLCEMEVQLEKLELDTQRDQCADEGEEVKRFFKLAELGGVAGMRAMLKGPNADVLLSAKVNGVTALSIAVQEGNAKVVELLKEKGAMDEKGPAVTFVLATCGHGGYQCRFCPNLGHCCRCCREPPPGCSRRPPGHSCAEEQGRVATPIEWAEGNLMDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3Z1</accession>
    <name>A0A914I3Z1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase family 92 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3Z1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6381.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6381.t1"/>
        <property type="gene ID" value="Gr19_v10_g6381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6381.t1"/>
        </source>
    </evidence>
    <sequence length="523" mass="61296" checksum="00498215D3BC6AD6" modified="2023-02-22" version="1">MLPPLFSQFFIELLLSVVVAIDVNLLPMKFVFSAPLLNMSQTDKSVRQTQIWGVPSEQGQPTRVKFSDIDCARVLLADDRAYVEQRAVSPLRFTDPPGDALPMNCTSIRGRYLQFSQQPKDRGTDYPLAFIRLVYTDYLFIEMEFASSYAPQNWYCYAIDKKASATFHHQMHALASCFPNVLIIPREKEYKMDRKGHNLMKASIECMQMLLEKHWHYAIMLQNHDVQMKTNEELVQIFKWMNGTNDIQYTRIGSDHVDFGKHKWSLSHLKLFRNATKNGDDLVLKKNKGQFQMSLNRKFVDWLLNNLDTSVMLDQLNSFHYSYDEYFIQTLASNEFLNAPGGFTHECFDKQLAPGLTRMTIWKYWVAKDLCHSGLYRHDICIYGLKDLVPNLNRSHPFLFANKMVLQKDAEAVQCWHEAMFNRTYLFPTLERLDKKFYTELPQVRYNALQKRTTNGTFNSGNFNCRYKFIDSVKMYQELRGEYKDVARLFKRSQNFASVNSDVAEQYQHWQQNEANASTKEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4H6</accession>
    <name>A0A914I4H6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Trehalase</fullName>
            <ecNumber evidence="2 4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2 4"/>
    <dbReference type="AlphaFoldDB" id="A0A914I4H6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7233.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7233.t1"/>
        <property type="gene ID" value="Gr19_v10_g7233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF12">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7233.t1"/>
        </source>
    </evidence>
    <sequence length="550" mass="62764" checksum="365EAAE95842DBD6" modified="2023-02-22" version="1">MLYYVVSLLSQIYCDGPILQAVQDARLFADSKYFVDMPLKQDPVSTLRDFYALGDRVKDSSVLEAFVESHFEPPGVGHCICTGYGVTFADESKTMFESIKSVTHFSMSHIHSSSLAGGFGNFITGIRFGFSKVCCSRRCMTRQRVVILNLIYMVDHHGFVPNGGRIYYLSRSQPPLLTPMVYEYFLATGDLDFVHQVLPTLEKEQHFWNLNRARSFLHPETNEELFQYYQYRAAMKGPRPESYREDMELAKGLSSAAEREAIWSNVASAAETGWDFSTRWFAQEGPGMHDIKSIRTWSIVPVDLNAFMCINMRYMAAFYEIFGNIEKKKEYYERYQKMKLAIKRLHWNETDGIWYDYDLEREAHSNTYYVSNALPLYSKCYDDEDDVTPHKVFEYLKREGVLNFTKGIPTSLAMGSIQQWDKENAWPPMVHMVVEGFRTSGDLDLMKAAEQMATQWLIVNYKGYVSTYAMFEKYNASMFNEEGCGGSGGEYEVQKGFGWTNGVILDLLDKYGAKISVAASAVPIGAPFFPLTLTVTTLLLMAAVEIALCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4T5</accession>
    <name>A0A914I4T5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4T5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g689.t1">
        <property type="protein sequence ID" value="Gr19_v10_g689.t1"/>
        <property type="gene ID" value="Gr19_v10_g689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g689.t1"/>
        </source>
    </evidence>
    <sequence length="566" mass="62702" checksum="77A03CA2CD62AE60" modified="2023-02-22" version="1">MNVESEKDESTELAGTELAGTELAGTELAGTELAGTELAGTELDGVGWDGVAGTELAELTRFVAFVRLARDRLGSASRAQGAPGNGTPPLSLPIVAVAFGWSRRSGDDSVVVRFVPRRRFPPAWNFDSFLIEQDRTADDFPGPTVQDPDGLILISSDQFWSAQSDEFGTTKNADAHKITDDLNTNIRAKNASADIKYLLNNTATSPVPPVIERIEIRLVDSQNATDETPLIIVDVVKKNGSAGVAATIQQAIQTEKPALDEDVGSPKPDKSFLVRLRQPNYHSVSFVPFEAATTTTTSEQPNLEANNADENQLIESTELPFVGQMVHIIATEDEVSRQSADQNDDKMTPGQMKTIRNEEDKRTDHHEADDSDDDDEEMAEELGGRDEFVVNEAAILGETTNLSAFSAYGVHNNDDTLSSASSSFSSSAEEQPNISKLIMQHNSRSNDGDEQFGDDAALTDQQEEKPDQQEVALASDPEDEECLANQAKLSRETVQKLRTERRRIVQTIQRINKQQRELCQPDQRQEHVPYRKCPMWRREKFFLYYALMRLTYCANYERWPSAKVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I524</accession>
    <name>A0A914I524_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I524"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6960.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6960.t2"/>
        <property type="gene ID" value="Gr19_v10_g6960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF10">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN CDGAPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="204"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="360"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6960.t2"/>
        </source>
    </evidence>
    <sequence length="880" mass="97714" checksum="8BF78EAD48A27C22" modified="2023-02-22" version="1">MLLGSDLAAALGTSASRATTPIGAQTPLIGDRASPASVRRRLLHPSMSRQRSPLFFAPNILRPNECQHFHYDFVELGPVRVHLVGMEEEEEESERKRNNNGRTEVKFTLSIESNGKIWQIVRTSAEMVEFDRQLHRCVFERRHSRLEELDTDNSRLKLTICCYTGRLSLLTGSLMRCYPVLTFFELDNRGNHFLPVEYSLPNIPAVACAVAICPFDASQSDQLRLRVGDIVSVVEIDTKCDEKWMRGKLTVPSNDNQQQGTPCDNRRFGCFPARCVRLFSDRLSLGEQLWMASNSGTSTVARRSLPSFLPRQRRNSDGRPSMFSAALIRSFIVRISKHASPHTTSFQSLSTVEKSSVFGVDLVELMAKHHGDKHQTEVADVVEQCIRVVESRGMEAGIYRQCGVQSNVRRLRRMFSSGRVPEWECPSVSDLLSSDIHSVGSLLKHFFRQLPNPLIPFQCQPKLIDAFGGYGSSVINGKELISKVSQIINKFPSAHYHNAKRLFLHLQAVSRHPRTQTNARNLAIIWTPNLIRNGGQQYPNYQLASLNLHTDICTFLIAFADKIFSDSSGNGIVVSRSSSMGSVEVDSWRRQHEHGKCIGVANSPKMAVNGMAMTSLVDVSETVRGTGQQQQKQHIGPVHSVLERSKRPIEKRKKQNDVAGNSTTIPRIGESVVVDHSTQLALGQRLLSPLGKSLDEMGHSMFRRVRSMRHSVRRKFFKESPEMSKSCHQLNESPLSTTVAFVGGEQSAAAPPVVKEDDSSSNDLSRPPSSCPFLAIPFADDACSASRSATLSPSCNSSDALSAITTRGGVKRELAASTESTKTVEKRVNFEDGTGQECDGGEQQNVEQFGENRPDSVESIPLDISRYDNVHSIVVTCAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I685</accession>
    <name>A0A914I685_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I685"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7695.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7695.t1"/>
        <property type="gene ID" value="Gr19_v10_g7695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7695.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36657" checksum="62C5F0BC2995ACB7" modified="2023-02-22" version="1">MFGFGRFNVLYDAENEVPQGKRGEGSNKQNGGFGHDGGNKLRRAKKEKKDDPKQRKVRSTIESALAFLEQQEGHDNKRNVASLDLSAIVCRINSYVLMLPAPGPEEGILFLKQGIDFSFCEQFVETIQYGADFFKGIVVKNFTVFETGFFNILFKHFAKTPFPQKVVPLLSFRLPLTLPWPQTNYLTEVPRHLEPKVLRKRDLLHQAKIECEVSDLPNFVPGSETWPGSGSEILDHGCFAFVGAPPSPSEPAEVLRATTQSLRTFDAHSSGTSARVMYKLRNEPTNTTFYVKMWYDPAMGIQRYENVEGITVRRETGATTVDERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6K6</accession>
    <name>A0A914I6K6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6K6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7975.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7975.t1"/>
        <property type="gene ID" value="Gr19_v10_g7975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="152"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7975.t1"/>
        </source>
    </evidence>
    <sequence length="319" mass="37245" checksum="6E076E3EC4041940" modified="2023-02-22" version="1">MAEMDNFYDKFIIVDEKLITDLARKKYCKLGCTDVCLCQQINWEFSDRPAFAGLGFTMVEHSRFLQIKDAASPSTNASVGPLAQIVTWISYKQTLKTELAPIWRWPRDEEITLNSGGTVKIDCYHSPSIIFRILQKREVIENPCPPLLGLDDDLTVHIGDCQVTVSASRLMVVSPVIERMLNVEMKEKKQRTLNLDAHGITMEQFMQFLETINDHLRHGRTFPNPKNVLYLLKLADYFQIDWLKERCDAHLVHCVEIPLIERFLLIEPYRLNNLKDFFLRRLNVEWLRAFIDANRKHVLPPSISKEFRFLLTDRLAHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I6V5</accession>
    <name>A0A914I6V5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I6V5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8045.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8045.t2"/>
        <property type="gene ID" value="Gr19_v10_g8045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8045.t2"/>
        </source>
    </evidence>
    <sequence length="111" mass="12139" checksum="C1E59AEB4009700D" modified="2023-02-22" version="1">MPPQEAILKRPGLNTENKCLLVIRCLDEFHEAKVIDEKCRVQRSHLHHPTNEHAYEASIDIVGGTNEGGGAVTTANVTILLHKPVVQNWHSPGLPPSLAQIGSNSLLKHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I710</accession>
    <name>A0A914I710_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucosamine/galactosamine-6-phosphate isomerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I710"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7497.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7497.t1"/>
        <property type="gene ID" value="Gr19_v10_g7497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF8">
        <property type="entry name" value="SIDEROFLEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="10">
        <location>
            <begin position="102"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7497.t1"/>
        </source>
    </evidence>
    <sequence length="571" mass="63624" checksum="8F6946C433B1AD82" modified="2023-02-22" version="1">MSAMCRIRFLTSLSIMSSRCHKLRLSLSAEEQSETFYRYLESVIEEQSQCNQMIILGFSGGSMPAFLAPLLARLPDQTIARLRLFPKMCFRLNSSKTIQRLRSLRPRLNANGWPMFDLLLLGLGPDGHTCSLFPGHPLIKESSVWMAAIDDSPKPPPRRITVTIPILSAAANLAFIVNGASKAAVVKKILVDNDPRYPPSLISSTRPIQWFLDGEAAKEMRLGFKEITEGRMNLDGEAPVPDSLTAGSNGLVRHLMFKPDITKPRWDQSTYNGRAKHFFAVLNPLNLLASNRTLEESRNIVFEYRKGIYPPGLTIERLWKAKHLYDSAYHPASGEKMLPIGRMCAQVPCNMVLIGGMLSFYKSPLAVIFWQWTNQSFNAVVNYTNRSGDSVSTDQLLKAYAFATGGALTAALGLNAAAKKMPPIYGRLVPFAAVCVANTINIPMMRQKEFVDGIELVDESGVPLGKSKTVAWLAIPQVVVSRVLMATPYMVLTPLVVNQLAKKAWFNARRWVSPAFQMLFCGVIIFFSTPLCCAIFPQLSHIKTSSLEPKLREKIAREHGHRDVVYFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8U6</accession>
    <name>A0A914I8U6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8U6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g77.t1">
        <property type="protein sequence ID" value="Gr19_v10_g77.t1"/>
        <property type="gene ID" value="Gr19_v10_g77"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024130">
        <property type="entry name" value="DAP1/DAPL1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15228">
        <property type="entry name" value="DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g77.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14621" checksum="00DFD3B61D29CEB9" modified="2023-02-22" version="1">MDSSNNINGVDADSELKGGHAPAEKIGGGVRIARKERNLSQQPLEAAEKEKGSASASASDSGDSAGGGGEVRVRAGASSVLAYTDLAKQTMMDYPEEAVRHYQDKPHPRHESHTAQRTNAAHMQAHQQFQPRRFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I907</accession>
    <name>A0A914I907_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TRAF3-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAF3IP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I907"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8012.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8012.t1"/>
        <property type="gene ID" value="Gr19_v10_g8012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.50:FF:000001">
        <property type="entry name" value="TRAF3-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.50">
        <property type="entry name" value="Microtubule-binding protein MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018799">
        <property type="entry name" value="TRAF3IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041476">
        <property type="entry name" value="TRAF3IP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040468">
        <property type="entry name" value="TRAF3IP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042576">
        <property type="entry name" value="TRAF3IP1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363:SF0">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10243">
        <property type="entry name" value="MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17749">
        <property type="entry name" value="MIP-T3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAF3-interacting protein 1 N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF3-interacting protein 1 C-terminal" evidence="12">
        <location>
            <begin position="429"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="122"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8012.t1"/>
        </source>
    </evidence>
    <sequence length="578" mass="64166" checksum="55AF54FD186847FB" modified="2023-02-22" version="1">MDTGRTKELFSALIQRPALTDQLLQRPPFKFIHDIVHETLCVSGYLDGLFTSDELDSTKAGSSRDNKMAFLQKLIDALNMDGHLDDVKPSKIVAGKEAEMTNLLLQSLASESALYVNEKKAVAKKTGVSSSKSKSSSSSKSKDEERRKNSSKKDRGNVKEERSSSKHRSKEKESNKLKTTEQVQEKRKSKNRDAKVATEAEKLSSTDRERRKKRSDSIPRNKTSTSITNSNNVGNPLMDENVLAQQSLDDIYKTDLNETRTTPGRESSGGTSKGGDDSGIAEEMSAESERHEPVNGTPVVGFNSTPEFIEFHPSSSSPTPMVATHSVRPGTAMGRPQTAIGRPGTAIARLAPPKPKKNVISTNNSARDENVPFNDQPQQISLILEENAEKEAQKEVENFLVAEDEEQMFVGVAGADFASEGASVSNLRQGDEHGVLVNRIVENTRMLEEKHLQEDGPFVETDELDVQEQRRVRAEIESVQRVLQRATQNVQPLVRTIEFVSDDFDTMLRELEECRKQSTVLERRLQERATGVSSQVVALGATLRALDSDIRDTREHLARSHANVLKNERKIVTMLDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9U1</accession>
    <name>A0A914I9U1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ephrin RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9U1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8018.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8018.t1"/>
        <property type="gene ID" value="Gr19_v10_g8018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02675">
        <property type="entry name" value="Ephrin_ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF29">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036872845" evidence="8">
        <location>
            <begin position="33"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ephrin RBD" evidence="9">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8018.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33977" checksum="5CBFA27EDE5CF947" modified="2023-02-22" version="1">MCATNFLMSFCHRLLQLVVVLCGCCCLSTTFGRKLPDIQWHSNNTIFDISNTEHVKRVHLLDRVTLLCPPPAPDGDPKFYEYSKLFMVSRESYDQCILQSSSTKQLGVCSSPERLSSITLVFRDVSPLPSAFTFRPGQSYFVITTSNGTLAGLNNTEGGLCATRNMRLKFDVLSLTDEADATNDSMSHNMHHEHPHHHHHHHHRHQQQHYHRALHNQSPQGSSQNESQYPPFLYVIHTSETSPHGEDGEEAAAWGQDSYEAGEDTESAYSSATSRTRTLTRKHCVLAVLTALIASWISIKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB01</accession>
    <name>A0A914IB01_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IB01"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8226.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8226.t2"/>
        <property type="gene ID" value="Gr19_v10_g8226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="237"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="632"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="733"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8226.t2"/>
        </source>
    </evidence>
    <sequence length="764" mass="80672" checksum="91D11B4260EBFF9B" modified="2023-02-22" version="1">MPTLHMTSTLPTSSSSSSAPLMGNIAGGIAGGGGNSAGGGTNDAHSPTAPFSLELLATLLARTANSAASTGTACVVPAPIQSNSSAFSANQSSPFATSEVALIQQLLRATNPLLNNAVVGDMAPSALQALLVAGVAQQQHRRATMLVKTELEEDELLTAEIKGSGTPPQTDKMETNDGCFKQAAMFIKTELGSVEQLQPLPHIEEEEEGAEEAKPNLQQHSQPQQQQRRQRVGGSSVKTAEVWRFFTQRPTPEQAATCQICQKTIKATNSSTTGMIRHLRSCHQTEFQQLQQARYLKNLKNDAVERQKVMLQLQLGIDPHSEASIEAIQAALESSLTALQSPPPAMNGGVAPKHSVEALISGDLRSASPNSTAQQRQLLEQIENFKTSRPTSMERLKKESGTDPTMVVVGKRGAEEVPSGGVAKAEMSASPATTPLLGTATKRRKAMSGLSEEFCQRGAVPSPAMTAMTSMVVDGSTTGDFHQQTTPRTVGKKSGASARRTMAMASAIPPQNAGPGETLAGGAKVVEQHQSERISDQIAAMMLVDQTEFLLERVGFRQFVQALVPGYTMPLGGQFRAEIIPRVAKQLQQLALFREELQRNNPFGMPPIGMLLNNSIKTVQYLHQQQHLFTGGSPTALSTSSSSSSDTPSGHVVVTNHSSNMTNLVSPSSSTEESGFHDEEQHNGSAFGSSNISGGAAAGNANGSGMGMDELVQQAAFHSQNISRSFTFSLDLNSDGSGENAGCDGIAAEKASGKEEDSDTNSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB71</accession>
    <name>A0A914IB71_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB71"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8338.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8338.t2"/>
        <property type="gene ID" value="Gr19_v10_g8338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036880874" evidence="2">
        <location>
            <begin position="28"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8338.t2"/>
        </source>
    </evidence>
    <sequence length="185" mass="20034" checksum="FE7FBA201DD3446E" modified="2023-02-22" version="1">MNRSPAVCHRRLLSLLFVFLFLWSTNAQRYGATHRSGGYDGNSKPQHNAGYGGHSSRHGDVEQNNGESGQSNQRWGGWRGRGQWEGQQQQNWGQTHNQEENQEAPQGGTEQSGQYPSRWGHQSSGRFPSNVQPQQPSTPADDNDNSGDNAPPSPPQPHSNSGSLHVDLPPGAPGTSDAGNADQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBW3</accession>
    <name>A0A914IBW3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBW3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g845.t1">
        <property type="protein sequence ID" value="Gr19_v10_g845.t1"/>
        <property type="gene ID" value="Gr19_v10_g845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g845.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17483" checksum="4E73CC276F1D6420" modified="2023-02-22" version="1">MSHRHRLLALRGSSGKGVDHTITLLKDEEVEEMAEANVQKWQIPGVRGYRLHLHSTKLPSAQPTLSGQFGVICWMMTTKECALRQANYVHVSDRCHSVASARRRLSREEISGAFCRGVNIIISININSNNLPTFPSPSEKQMNGAQISEEMNESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICZ8</accession>
    <name>A0A914ICZ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9464.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9464.t1"/>
        <property type="gene ID" value="Gr19_v10_g9464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037413500" evidence="2">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9464.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10943" checksum="C681538878BB62B7" modified="2023-02-22" version="1">MGIRLILSVIFCIPLLFCAIWPRQECIDEIFFWREHHYTIESMRPPCVVTFIHWSLSTALIGCHYYIIFCGYNAIRKRLYKWTSRPSNLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-06-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEU9</accession>
    <name>A0A914IEU9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g958.t1">
        <property type="protein sequence ID" value="Gr19_v10_g958.t1"/>
        <property type="gene ID" value="Gr19_v10_g958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g958.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17989" checksum="2BACF003AF799845" modified="2023-02-22" version="1">MRTVHPRGGDVLKRPHTDHFLGRISALFDAFCSPPVWLSMPTRWSTXLDNRRGFRSRLFGKSRVFYEGIISRTFPDSGTLWFDDPNDQELLDLLPLLEERHYVDDIYKVSHRHCASLVQPRSLTPSKDMLLPKPMEPSRRITQVLASTTVTEADVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFF4</accession>
    <name>A0A914IFF4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFF4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9413.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9413.t1"/>
        <property type="gene ID" value="Gr19_v10_g9413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9413.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9058" checksum="02C33C3A1A396732" modified="2023-02-22" version="1">MPKNPTGTSTGPLKLHMLSHHSEIENREHKLIDHQLAHTDERPLECTICGHRSSQAGTLKRHLRNHTGEKHWHLRKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFS8</accession>
    <name>A0A914IFS8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFS8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9841.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9841.t1"/>
        <property type="gene ID" value="Gr19_v10_g9841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="11"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="332"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="375"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="456"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="595"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="631"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="782"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9841.t1"/>
        </source>
    </evidence>
    <sequence length="832" mass="94429" checksum="305505B5ACD3AAF8" modified="2023-02-22" version="1">MINRFIRNFLNGQHIIDKFRHVQTVRLTFLHQYIKNVCPAAVLSCGVRMASSSSSSNRPSHRSKLLADIYKNRTANLQLTNLGKDVVEFAQDSQGSRFIKQKLERANPTEKAQLVDALRGHVVTLAMHKSGNHVIRTALETIINEILAQVLPLSLHEYGNWVIRRVLEHCTEQQKRHVLEQLHGNVLSLVTDQYGNYVIEHVIEHGTEQQKRPVLEQLLDNVPTLLTDQYGNHVIQHVIEHGLPEDRERIVRSLQGDIMKYAQDKFGCLVILKCLICGTADQKKALIDNVCVGGPKTLRNARQLMADEFGTFVIQKFFEYGTDDQKAQLVDALRGHVLELALQMYGGPVIQAALKSILEELTPRSCVIKCIKDHYGSYVMNMIFELIEPQRLQFVVDAITNSPSDSVASLSVHQYASRVIECVLEHCTEQQKRPVLEQLHGNVSKLLEKNRTDNLQFADWSKHVVELAHDPRGSKFIQQKLECANSTEKAQLVDALRGHMVALALHKIGNHVIRTALETIITEILAQVIPLSLHEYGNWVIRRLLEHCTEQQKRHVLEQLHGNVSTLVTDKHGSFVIRHVIEHGTEQQKRPVLEQLLENVSTLVTDKYGSYVIRVVIEHCTEQQKRPMLEQLLENVSTLVTDKYGSFVIRHVIEHGRPEDRERIVRNLQGNIMKNTHLHSFCSIIEKCLIFGTTEQKNALIDQVCADNGSGKPALLEMMKRPFAKDVVQKMLNVADSARHQKMMFVINTAPIKNTKKRSANLSVLFLFCSDLENRTGTGTEQAKLEQQNTAHHYTTKADAYRLPKGRTAQSPTKKGRSRKTDNGRASVPFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFV3</accession>
    <name>A0A914IFV3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFV3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9487.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9487.t1"/>
        <property type="gene ID" value="Gr19_v10_g9487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9487.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="18880" checksum="555EEEC28FA42C18" modified="2023-02-22" version="1">MASHSAGGEGTAGGPLPPAERPATPLEGRERLADPCPQQNGQPLRWRGGGGWRTPAPSRIASHSAGGEGAAGGPLPPAERLATPLEGRGRLADPCPQQNGQPLRWRGGGGWRIPAPSRTASHSAGGEGSAGGPLPPEERPATPLEGRGRLADPCPQKNGQPLRWRGGSSWRTPTPSRMAKEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GQS0</accession>
    <name>A0A914GQS0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GQS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10320.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10320.t1"/>
        <property type="gene ID" value="Gr19_v10_g10320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10320.t1"/>
        </source>
    </evidence>
    <sequence length="425" mass="46795" checksum="4412DF4AE9C2882D" modified="2023-02-22" version="1">MDNPSGTDLLIGYLSLSVSCLAFGFAFVPLKRYDTRDGLFVQWVQCSVVFMAGLIINIARGLPPFNLTAAVGGFLYATGNVASVPIVAEMGIGLGMLTWGTVQIIVGWSVARFGLFGTKAQHVQSPFFNSLGVLITLISGLMFVFVYSRQNVADEVENGGGRATQSNIVPLNSTSSGERTVPSIRNPPYGSVNITTDEGQRRPQKLLFVTLAVCLGVLHGLMLTPIVYVQDTDQRASKNALDFVFSHFCAVFFFSTFYFVLYSLFRRGRPYVNPSLVLLIGPLPKHKKSASLCCLRLALVFGMNLFIVSNRILTQPVSFPVTVRLPAIIGAIVDVFLFKDIRRRRRLAWLFAAIIPSVEPDLEVDAADIPKDKRFWLPLATCLVHSHPMLLPLDADSYTDQEAFELLTKNIKPTDENGTEGEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRI6</accession>
    <name>A0A914GRI6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MFAP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GRI6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10638.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10638.t1"/>
        <property type="gene ID" value="Gr19_v10_g10638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="4">
        <location>
            <begin position="230"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10638.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="58276" checksum="16C05E3C0BDAAAB7" modified="2023-02-22" version="1">MGDFVPKFERNLDNKPLGPRPLPTAGAIPVKDEKGRIVMKKVKVQRYMAGKIPEFARDSESDEDFQQNNEEENLKEHREEKRERELHRHERRDKEKDRERGEHRHGRKDDKSSLRRRDRRDQQLDEYKRELKEEEAFAVGEEEEEEDEQTRDERHHRALIRRRRMEQDEAPLEQEDLEEEADEDERQRRRELLKRIQQRHEEEELLSKQPDAGEVSEESEEESSEGEEEDSEEEMMPRLKPVFVPRNDRVTLIELEKEQAKLEQLKFEEEKRKEEKKRLTARLVEEQLKREVEQDRAKREEGAQLDLAAVNTDDESEEIAYELWKVREMKRLKRNREEREALARDKEEMERIHNMTEEERRNYLRMNPKIITNQQNKGKYKFLQKYYHRGAFFLDKEDDVLRRNFAEATGEDVFDKSVLPKVMQVKNFGKASRSKWTHLTAEDTTDHQGVWATPTPLSAKFVAKYAAGMKNVFEKPSAKKRKIAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GS69</accession>
    <name>A0A914GS69_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GS69"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10788.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10788.t1"/>
        <property type="gene ID" value="Gr19_v10_g10788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10788.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37368" checksum="9FF2F8B8DC0EDFFE" modified="2023-02-22" version="1">MILLLTQHHHLQQQQQLQREFVSMNFDDVNEDCANGTLSRTYSAWSIVYRQAAAEIGSSICSTSINIWYGQIVRYVVCNPGTVRAVDQAQKLINDLLAICLEMLCTRTKFFSMESQRTIIQIVLVPLIEKGAVDKMWRTSSKCRKRLPQAKSHFPSNNNIEQLIDYQQPNQGVLVLIKLFSAMEQLLFANAELQRHFMNATTRAAKKRKKTIHSRTLFFSHVFDIEVLISQPQLFFTVRDDETVRVWYLNNSNNIDHRQNTAAVHRTKILSAFCRTPSTPLPVCVALNSARLAHIWGQTEQFKNDLLRQQHVNKAGRRKSRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSL2</accession>
    <name>A0A914GSL2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Cyclin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GSL2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10995.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10995.t1"/>
        <property type="gene ID" value="Gr19_v10_g10995"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6824.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6824.t1"/>
        <property type="gene ID" value="Gr19_v10_g6824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="96"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10995.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6824.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21714" checksum="D714CE6947A5F939" modified="2023-02-22" version="1">MFEAEKSNGTNAVALSPPAAYKVTAQSEKSALDALMAKVRASSYGQLRNYSTIDISAEKWLMHYDAASLAKLENPPSLADGISRELERDIRYLGCELIQSGAILLRLNQTAAATAQILFQRYYYLKSFVRYNFEHMVQACLLLASKIEEEPRKPRDVLNVYNRLKQIHHRRCAAAAADQHPEAVQKLAKKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GSS6</accession>
    <name>A0A914GSS6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GSS6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10952.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10952.t1"/>
        <property type="gene ID" value="Gr19_v10_g10952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10952.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27685" checksum="C98FD9B7DAB539CE" modified="2023-02-22" version="1">MDIKTLADYLRRIEEEAQQNPAGFGATDHLPNQSQEWDFSKPAPPFIQAPQIAQQSSNFTSGNPGSLTSALKRGKSIDFSKKNSDNWPLSSITGALSHYAAMPSQQVPPMHGTFVQSQAGTDSTIFFGGNSQNNEGTLESMVNPKNPSSWKNAWGAVSNLFGASPQEPQFSPPSMHDTSAASSYYPSNQPDDQTLQSMITPRNQKVCVIPTWNAFLDCSGGNSQNNDGSLYSVVNTRRPSSSIGKNATKPGKKPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTR3</accession>
    <name>A0A914GTR3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ELYS beta-propeller domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTR3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11175.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11175.t1"/>
        <property type="gene ID" value="Gr19_v10_g11175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11175.t1"/>
        </source>
    </evidence>
    <sequence length="1231" mass="139816" checksum="A15EBB37433B5D4C" modified="2023-02-22" version="1">MSIRNIPEVLKQKLVEVEGTSKTTSPQTSVKENLAIQSSESPFIENGRFLLWKGVETGFFYLAGHPSPGSLAVYDYKNGTANAVLHFSHQFGRTALIVDAIYFPLSADHPGIVVAVTDRSVDKHGDYLAYFSLISRSLLNAFYLQYPITSICAILDGSAERAQFLRLSSSFHKDWPHILLVGCRYGYVSLVYLDLQDERLSAAIVPNASSPSTLLTNKNDELLPVRCKKNVHLTKIFYEDQMFVFRADDGTTKCLAKEKVVVSALHWVEKCGLAVIGFNFGGVMVVSLRTSKVYSLLYIEGIVQHFAFQEPEEDPRPILFFWIAFNSPRSGTSLLLCNMNFPKDEERTKLSADGGEEYTYLDPQFAPCMKWPLDNCTRLITMRTIHMQKGTSNGSGADSDRFLDASYSREFVLKPKTDTSLLFVTWSELLQHGEKRLHGALFDLNAFYAKRLIPKIQPDSTVARQIPFISRFSSQKLPSLHQTLLDIMPNVVYRFSPLAFLNESIDQLYYPSTYHLKNNTLTSARVFQTEVQPVQVQLIDELSQNFVNYFENPTQCVAWIHAVGLANSAPSANINEERVCLLRVVMHSFFPGIVSLIETSSDSIELLKFTQKWIWRELEITKAKFDDLCSPLFANPPHELSPNSQGFFTLRLRSWTTRIGFGPLLCMKQLSASRLYAIVTEQFARRVQKSKIRRKLQIHKLVGQIIDLNKQDEIWQGKTAEWYPPRDFTSLLPILLFVNITETAKTELIGYYCLDLEAAAATFGSSVEVKDGSTPPSYSFFSFFLSVLSEENLSSEEMDRVKVLWSEDKLLAEANPETENMLVSSADRISRQTSPNRADILQLREEFLKMDWGLYKFNELMLERGHFDLLLEMTSLKGDEPDFVQKCHGRCLDVKRRFPTLFRKRKALPLSIIEKFREKVVRRNDCRHLLPSQEYEPVDQCQLVLPINKFCAASFLPIKMATPEVNSQTFDVRRSENAAELYEELPLTIATPKRKEQRVFFGELTTPNANCTVNIEPFEEQPETPGATPLAMTPRPKEKRSPVVCKIIQKESVKAKDWDRIVKITQTPLSLRKSIGDTSKLPLRQQRSFERARTVLFPTDTAQQTGNKIVTRAVAKKMDRNGFDERASTLTQSRLCEFDQNEQERQHSPLPNMDNAVQPPSILKSDRKRSRLPTDSLSCKPRLRFAQALFTTEHIPSRAEKAMDQDTSFSNFASLSGSESSPASSSKVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW52</accession>
    <name>A0A914GW52_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW52"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11888.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11888.t1"/>
        <property type="gene ID" value="Gr19_v10_g11888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11888.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8413" checksum="3F92284FCB09FAC2" modified="2023-02-22" version="1">MRLSFVVLIRLTAIIEKISENEMEANVGRLGNAYKIANGWAKNAFVQGKYIGEEEDEDDEEDQDDGGSSTEIFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GW62</accession>
    <name>A0A914GW62_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GW62"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11325.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11325.t1"/>
        <property type="gene ID" value="Gr19_v10_g11325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF26">
        <property type="entry name" value="PROTEIN TSCT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11325.t1"/>
        </source>
    </evidence>
    <sequence length="415" mass="45305" checksum="2C18BC9FF57831A8" modified="2023-02-22" version="1">MANCAVLDLYKMEQSNIETMRSKTKLHHDGVLYVYDKMSASGDVKFWRCEFSNARDVRCKGRLHTDLNGIVQRVVGEHVCPSSAARVESQRIITAIKRRAVDTMESTDEILAHALQNVSPSVLAAVPSKNAANKLIKRARTENKGSSENFKHLESLESSHSVALTLTIDADGHNYGEQCQQTLASSAQFPSVVVQTNQQQQTASTSVSNQIHQQRVPKPDFSATSCLSNFDISTTHSVPIALADYVSQGNSALDSMANAIGGKIVTVSSSMAYPSPIDNKIEQALDLVKTQLTLAVRKEMKLMRSTIIELESKVSLLEGENRILRQYAPNEVEANLPALVQQMRDRQQKGASASHNYLNQSRTAPSSMVEHHQTTSSGPKTGGGASPPCPPVANTAWDGRVKQSEIKSDFGRNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWC4</accession>
    <name>A0A914GWC4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWC4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g118.t1">
        <property type="protein sequence ID" value="Gr19_v10_g118.t1"/>
        <property type="gene ID" value="Gr19_v10_g118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038123599" evidence="4">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g118.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32629" checksum="1F2DF4260308A39E" modified="2023-02-22" version="1">MLCFNFNLFLALAATADGQRTECQKNFNATELINSAPNVLNGENAQKWVQKHAFGVLCCKKFEPKFEWADSVEQKNIFKILQKLKSEFCRQLDEGNGMEMAAQKVQNLTRKLAQILEETPKIRENIQKAQENAKNGAKLDKFEIFRWKDLLSKNNLTTKVQIDQLMQNVYLAFNAFANALKGRPNKQKCHHRRQTGTPAATGRRRRRMNTFSTEQGGTQRATTTTTCDDFRCLFFLVLSVATFASAGFAGYVMILNMNALNILFLAVMVSLFMGSAIVFIRQCTEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWE5</accession>
    <name>A0A914GWE5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trafficking protein particle complex subunit 9</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NIBP family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g11380.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11380.t1"/>
        <property type="gene ID" value="Gr19_v10_g11380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11380.t1"/>
        </source>
    </evidence>
    <sequence length="1316" mass="148436" checksum="61F1D9C0BC499CEE" modified="2023-02-22" version="1">MESILPKPEDHCRIQILVKPLGNFATPAFNRVIKTLERRFATVQVSSNVSSQRQILPKLVTDLNLVLLRFGEFQAFRKIFGLLCIGQFNGGHLNASSSSPDLNSPSSSRNETLNDEGQASSPPLSRLRRSSLARLPPILAERQKKGDQNISDELTPAESKQFRLLKEQFAEIKQSLNDQLVDSRCALFGFGCDSSCTTEFLSLTGADDFSSICDHLESILHELLRSIYFVLESRRLDTSFERMDNPSCPMLPDEEKYRMGLENVKSKAYRRKCIGRLRKKAGDYAFLTGLFEAAVQSYQSAIELLKSTADLLWLAAAYEGWCCAAMMIKYRQRMLSNRREEIDGNGHQKPMHRVQTAVDASNSSKEHQLKSSIGHQRYCSDEVTKITTDTNGPSEDEAEPKNLSNNRSFFSGKSSSKRKAWRQLLNFDSSSYSQQNVKTAPKNDVPRTWPLRRFPPQQLLLINALISRNELSERFRAALENYGRFSFAVYIEYECMMRAVHLLVFHRQFIEVESFLREHTCRFLDDKFLTFNNIMKSNICLAASEVYNMIGFKRKYSFFLRLAVFFRLFIENHSENDYKRVYPILNESLHGYGIGGKFCKEKVPNCDRFATFSLQIKAVHEVCTVAVRAGLHNMAIRHLCFMLESFFDHLDKGNGLHVLFKPLTLDTSPPVLLAPLQLTRIPSLKDFQVLPLSQHLAPKIVDASALRSKIFIYSPFQERTKKDELCWVVDCASEVSVKVQNPLPVDLLLNFSASRDQLELYELRVTFARNHRQFTVRVLPSLPSLRVDSSLKRSPTLSDNPNDSIAEVCVFSGQSYDHTITLSNSSSSLGIKHVTIKIQQPQTCGGPNLIQIVAGNCDFANDPSTSADYQINGLKAGERKRVNIRIFGIDPTSTAFSDSHLGRPGGNPAQIGQEHRVFVRRPTSDSSSTATIVPDCVVPEAFSAPTMSSSEGRKHRQPSAEASPLLERENSTEEHLTGRHDLMPYVGRLLSAEFSFTYSADLQTSPTEEEFVRFAKLPMAVTIVPAVNVSSWCVLAGDSPFSRLVVVDVANETDLEAELTFGVEHRLTVQPKECCRVPLLCPCCDDIQSIAFQRATQQASHMMQMQEIERLRRMLEKHLTKHLEIRWRIAKLRLEGQVPIGSLLSSVAFLRQLVLPSITIDIKVCGQNCATDEDVLIRMGEFVPIRVIVYCSVEGGISGELSLACSQQHNKNETASGRENNNMLICGEDSVPFQIFRTDKEREGGPKSQCEDKVGKFETEFYAAFSHEGNFKVKPMLARLRFYDNDEEDAGKGRRRAPGEEDIFQPALSLNVISKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWJ5</accession>
    <name>A0A914GWJ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWJ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11830.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11830.t1"/>
        <property type="gene ID" value="Gr19_v10_g11830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022559">
        <property type="entry name" value="SUP-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34149">
        <property type="entry name" value="PROTEIN CBG11905-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34149:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10853">
        <property type="entry name" value="DUF2650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11830.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21123" checksum="411EC6CC033D2878" modified="2023-02-22" version="1">MDFLFQRPPKPLQYWPEPPPAPSDFVKPRNFAEKHFGQWCRNLTLDRHVQCPKASPFHWYICCGDDGTDCCFGIQTWAYVVFGSLALIFSIATVFWLYLGPTNYSGAKVVDTSKRQRQQQQHNNGCLPTGKGYGDSSSTTVLPRSPTVVSVDDDNILSSPEGTLLTGSSPSPNSTGKCADDDEQQQCPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GWT5</accession>
    <name>A0A914GWT5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GWT5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11917.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11917.t1"/>
        <property type="gene ID" value="Gr19_v10_g11917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026135">
        <property type="entry name" value="C6orf15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15817:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2300002M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15817">
        <property type="entry name" value="STG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11917.t1"/>
        </source>
    </evidence>
    <sequence length="824" mass="89615" checksum="2D45516DBDA3EBFD" modified="2023-02-22" version="1">MPSSKIIAPPPRRGAVQAPSQSLNWSPTHPKHPWTDACTLTRLLLDEKVEEWTKTKLEEHQKNIGSKRASGASSPFPLPQFNPPGGGVNVQNSPSLSTLRAGRPMLLRKKTFGGVSHSSRTISMDFDSETSGTTDDADRMDFVFPFIPSTPITQFPLTSSTPITQFPLISSTPITQFPLTSSTPITQFPLISSTPITQFPLISSTPITQFPLISSTPITQFPLISSTPITQFPLISSTPITQFPLTSSTPITQFPLISSTPITQFPLTSSTPITQFPLISSTPTTQFPFISSTPITQFPFISSTPITQFPLTSSTPITQFPLISSTPITQFPLTSSTPITQFPLISSTPITQFPLTSSTPITQFPLISSTPITQFPLISSTPITQFPLISSTPITQFPLISSTPITQFPLISSTPITQFPLTSSTPITQFPLISSTPITQFPLISSTPITQFPLISSTPITQFPLISSTPITHFLSSHPQIASKFCHLLPTSIPSNHPIEFRMIGPPFSNVVHSSRQQQNGNHFLGEEESCPEGTMPTGKSQMNGEGGETNGTTEKGQVRVAGGSNGNSSISREPSLTFPTHQKCNGKADHMTINNAHRPEQKHQNHPPMESPNIAARQQLHPCQQTQFNGAQFDTQSLRSRSHSISHPNNTLPPNASHQQHHQHRQHSSSGGFRYGSCTNLSALNGSGGGAGPLVLYDGGVGIDAECPPTAPQRHSMALIEAQMPSPYWYHQPQPMLHPPPPPFYYTAATLPHPPPMDLATFRRALKESERMEKERKVLVGERGLCAACWEFCCGGSALILWLVITLIALGFLGFLLLAIYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXX5</accession>
    <name>A0A914GXX5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GXX5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12359.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12359.t1"/>
        <property type="gene ID" value="Gr19_v10_g12359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="496"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="867"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="711"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12359.t1"/>
        </source>
    </evidence>
    <sequence length="934" mass="103545" checksum="4251BEC802F3822D" modified="2023-02-22" version="1">MRTTIILETKQLMPHQIAKNLVAARIRKKAFIWFRRTTTAMENIPRWDKDLAPNCERPQTEQEHQLLRGPGTSQEMASSGNTNGFGYATPSSNVWVSSELLAKMHQQQQQTSITTRNSTIIPNCHSFSSPTSFDTNNHQLVVSKSSDLRTRKRFYNQSLVIFKNGKRLYAGSKDCFQFLETGNCLNGVFCEFEHDGSAEHAAKKVCPSLMRGQCRNSGDTCPDGPHSTLMQHQMPVCDYYLRMCCSKGKDQCPYLHVKHTDGMDPCDEFNKGCCQQGVMCNSPHRYRYHRIKEKQMERSKLSANLQEYGTDRHKNLHSTSTGIKNDTLKCREHVKKRKASTSEGSDELGSGREEQQQTENIAASRQRRTAAMKSHKVWDVLKPGAKGHAEGEADPNEAQPASKMGRPPKRKAQGVSSFTSPTEENVKMEIEPSTEIQQGQQDEKIFDQQSDQKGSQRIVLNRKVAATSLSATNLWTQPQPAKDRGQLQLIEKEVEKHQQFADDPMTNTEEPSDEEDEDRMSPQGDRVLLDDPNDEDYPEFPTRAGRRGRGEGQQRGRGGGRGSRGGTATAAHSLRGTTSTRGRPRGSRMPMGGGVMGGRVNFTLGTGRGGRVPMGYYPPPRGSFGPGGTPSIYSIQPSGGIVGDLPLRPPSVRIVRARPAGEVAVHQQNASSGFRPLSVRPSPMVQYNEESFKINRELENYRDSIVPGASVQQFNDIIDQLLDEMSRAAEDRDKLTASHREYVDHLQLTHSAAQEIKDKRIRQLEQSLDQMQQKLMLSFKNEQLHLVKNTVEGSSQERGGGVLERQSSEHQQLSQDGARGGGVGDSGPAGGGGALNTSSAVSSVPSQMENLRPAGTRVRIAMGSAVEGGEGAGQQAQLGLNSPYDDDYEDDELDDEEEFEYDEGDSADIDDDLGAQRRLSLISRFRKLHKVIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GYJ0</accession>
    <name>A0A914GYJ0_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="22">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="22"/>
    <dbReference type="AlphaFoldDB" id="A0A914GYJ0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11962.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11962.t1"/>
        <property type="gene ID" value="Gr19_v10_g11962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF20">
        <property type="entry name" value="MITOFERRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="19 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 22" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 22" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="12 22" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 22" id="KW-0820">tRNA-binding</keyword>
    <feature type="repeat" description="Solcar" evidence="23">
        <location>
            <begin position="267"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="23">
        <location>
            <begin position="364"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="23">
        <location>
            <begin position="455"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" evidence="22">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11962.t1"/>
        </source>
    </evidence>
    <sequence length="616" mass="69104" checksum="F3F3E770F62F06D1" modified="2023-02-22" version="1">MSVSQIEANASASPPIDNKEMMKYPQKRFYRQRAHSNPMSDHDLKYPVSPEEMDWRDLFGPSAEGRPPEFADIGCGYGGLLVKLSQLFPNITMVGMELRVKVADFVQERVKALRAQNHGCYDNICCLRSNAMKNLPNFFHKYQLSKMFFLFPDPHFKKTKHKWRIISTSLLSEYAYVLRPGGRIYTITDVEELHHWMVDHLERFALFRRISDKEYADDPVVPLLFESTEEGQKVTRNCGNKWAALEIENMPEQSSGVDVYESLAPTYSLWVHLAAGAAAGMAEHCVMFPVDSVKTRLQSLCPCPESKCPTPIHGVASMVRREGFWRTFRGVNAVAVGSVPAHALYFTVYEKFKSLLTGNTHGHANTLSYALAGMAATVFHDLVMNPAEVVKQRMQMLYSPYGGSLECVRCVFRNEGIAAFYRSYSTQLFMNVPFQAVHFMCYEYWQEQFNREHKYDPASHLVSGGLAGGLAAAVTNPLDCVKTVLNTQQSPQPVLDKRSLFYLKGSYNGILDAISSIYSTRGFGGFLVGLHARVLYQVPSAALSWSVYELFKYLLGEQSTATSSRSSSISEALPTNASTPFPTSQSAETTTNNDIGRVEQLFANKPSGAFIESRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0A2</accession>
    <name>A0A914H0A2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0A2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12047.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12047.t1"/>
        <property type="gene ID" value="Gr19_v10_g12047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12047.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42153" checksum="A61ABD63203C9366" modified="2023-02-22" version="1">MEKQLARRRGVVHLGAHVWAPAGDLSHSFVKKKSEHEERMVPGVKYECATPFSDGANVAIDKDGLLSLIKAGCLRDALYMTTKLLSNIGQGLGMTGRQSQNTQLSLEVWSCRFQLMMALRMHSQLLDELSAFGELDSSDLFLQHYPHFAGQKGTLVPFSLRLLHAEVPSFSPFPYSSIVRAHKLIEDTAKAIEIVRQNFAASEAELSIWHERLEEAWMVKARVLFRLKEYAKAFERANVRKMLFMMAMHVGDGQKLVKYKDELSKNGIVAEEDIFPAFKAVFDGDYNDALDHLQKMKAQNPDESASDPKLCNNEAVCLLYCGKPVDCVQLLFNHRGPVAVPLALNVATSFLDGFTRDKRHNNLFEPAEVMRMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0A5</accession>
    <name>A0A914H0A5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0A5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12857.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12857.t1"/>
        <property type="gene ID" value="Gr19_v10_g12857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12857.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39861" checksum="1A3AE9A6229C399B" modified="2023-02-22" version="1">MEIFFDSKRYDALFNCSSYRVDDVPFEQRQNVPFGVSMIIIFFIFMPLHAICLCAMRNFLAHSSAYKVMFLMGLGHICCLSVTALLTGIFSLIGAVFCSMPILNFFAGTVALFSWALTTSLSVLLALERCAEQTFPNLAKTLFAGRRIWGWCLAVLAYSIYYGFFTIPLTFSGLTANWQFDPHVGYLDIPDGQNLYWNSVDVTHTIVVAIALPTLYLLFVVMLSLKLTQITKLPMAEQKMRKSVFVQVFVLSSALTVFAVNYTLLNFVSVPDVMVSINMYLWVLLDGVPPLIYLSLNASIRAECLRILRRRNSQQNLPTTFGRHSRRSHFACTMNELMPTKMIVNNFVDPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0H8</accession>
    <name>A0A914H0H8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0H8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12104.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12104.t1"/>
        <property type="gene ID" value="Gr19_v10_g12104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18369">
        <property type="entry name" value="BTB_POZ_KCTD10-like_BACURD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000046">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12104.t1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39379" checksum="8557291EA62EEF4E" modified="2023-02-22" version="1">MSSAMAADSNEDNGSPKHHLIGHDQYVKLNVGGSLFLTTIGTLTKYDSMLKAMFSGRLEVRRDRDGYVLVDRCGKHFGLILNFLREGTLPLPECRQEVLEILIEAKYYLLQELVEHCYSWLKTLQHDQLVSTLGVCRVPIVVSKKQVEQIVQSCAGKPVIELLLNRQNNKYSPLYQKHWNRKSGNLPVDFLRKCESQSRGLLHFNYLRNGQKADKTRIYEEALNVLLTFDHQGLSGVCTRCKRPNDDGSVANWPDFLAELPAELNTGLKQLGPEAAASIAGNGRIDWRLEQLAIGALIGAEEGGSSGHQLRRKNAVNDRETVNNSNIAGGSSSTVATAAAAAMCPKGPQKMSECDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0N9</accession>
    <name>A0A914H0N9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0N9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12149.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12149.t1"/>
        <property type="gene ID" value="Gr19_v10_g12149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000748">
        <property type="entry name" value="RNA Binding Motif protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12149.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9222" checksum="3A7D45ABC5C6E4F3" modified="2023-02-22" version="1">MASSGFSVYVGNIPYNATEEDIGNMFSSCGVVTNVRIVYDRETNRPKGFGFCEFQDQQSAQNAVTNLNGAELHGRPLRVNMATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0T1</accession>
    <name>A0A914H0T1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0T1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12574.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12574.t1"/>
        <property type="gene ID" value="Gr19_v10_g12574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="47"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12574.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="29657" checksum="153A015FE723B622" modified="2023-02-22" version="1">MKIFMAEIIVFFTQFVQYSDSQFSSASSHQQQQNKPPPPPQTQQIHSVNTPFGVLRGLVVNPVDKSAGAFPALKPVTQFLGIPYGSAPTSNHRFKMAISASKWTHQPKDAFKTPPSCIQSGLPTLQESKALKVTSVQRFDRLHRVLPLLKPQSEDCLFINLFVPEREPRLSPQALSVLVLVHGDTDFAWGGANAQNGTMLASLGQVLVVTLNYRLGVYGFLGRCEPEARACAGNAGLSDLVAALKMLSNLLPSFGADPNSVTLLGWESGAALVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H119</accession>
    <name>A0A914H119_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H119"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13046.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13046.t1"/>
        <property type="gene ID" value="Gr19_v10_g13046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13046.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10365" checksum="0C1109BAF68792EC" modified="2023-02-22" version="1">MPTERTTRVEQWVCQWCDHFVSATQNFQLLSTFANNNLSIWYFTICSSFEQLKINASIGLPQCTHCLCRVNDEYLPVGRFIAMIWIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H1H6</accession>
    <name>A0A914H1H6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H1H6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13278.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13278.t2"/>
        <property type="gene ID" value="Gr19_v10_g13278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13278.t2"/>
        </source>
    </evidence>
    <sequence length="667" mass="76231" checksum="42AA48E619E885D5" modified="2023-02-22" version="1">MHGGKQLRASFRIQRKQNTLECDCVGGTDCQKGCTKQSYNHYKSPYSVFTEPKISRPTRSCPAGPTNNQEKQQFNKFSTPLEIQATIHERSGSYENFSTAQLEQLCEDKQRESGKGSESWKKAVGQDPAERPQKQTQRQQTEQKRRRDMTLTEEIGKRMKRCQNRCGRHSITQYCHQQQPLSTSEYWSADPSPISENQPYFHHFRISPRVPPDVGEDEESSSVDGDNSSDDQEISPTALIQAWECQVRILTQELRACKGVAEKYRSKYLRLKARTEELNSELTREKERNSWLLNQLIATNDMMTQLSWAHLHFRDIQKHNFLKGADVADNEMRPPPNYPFGALLEDFEQPDKCERNARHRSAAGEVQAELSSDEFDDRATAIRKGLWAVEPTSLGGVGQRVESENGQQTINSKCKQQSPLRTPTPILVESANEHIRNQLHVEVARGSHLNSSRNSNSRLISPPFRTGMKKMVNNNSSEMIEEDNDEQLEEDEEDSENFIGTDPEEQDQQLVVIPLDAFCQQQQLGEEKGGRRAKGKRETRKLRGDQTLSVKLLLRHSRSSEDLRSTGKEFFGNGKRMVGSTMPSSSEDDIRMWKKQLRSRGERVLFRPSRKSLLSGAIGDGKGPRIFRRFGQREREALAKFDYLLDERTDLSGLMSSPEKLAETKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2L4</accession>
    <name>A0A914H2L4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2L4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12660.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12660.t1"/>
        <property type="gene ID" value="Gr19_v10_g12660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12660.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11812" checksum="867A3CE96CCD73B7" modified="2023-02-22" version="1">MPKPNSSLGRMEHMLSTGDDADVHFLVGGGEEKELLPAHKLILKAASDVFRAMFRFDAENAKSAAAGTVTDPVEVPDVEIGGVQDNAQLHLCGRFEWTGRGQCNRCALCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3E8</accession>
    <name>A0A914H3E8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3E8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13483.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13483.t1"/>
        <property type="gene ID" value="Gr19_v10_g13483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="9">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13483.t1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49410" checksum="6F2923F1E9F4B82E" modified="2023-02-22" version="1">MQTTPNKKRNANDLSSLEVGGSSMQITPPKNSKLDGNESVDQPMETTPSPWRRHYQMNALGAALSHYFSPNKRSPGRSPGRGLAQRKLQLSSDSEGEREEEEENIKPKKSKKFDNSNRCDFAAVKCCFDVQKELDNHLPSQVESRPNGRTIGQHFEEWLRLLESGEFNILLHGLGSKRLILKQFGDFLISRAHRIFVVDGLNPSDTVPKIIERMAEELKLKGVAKVKRKSVETAAETLRDCIDKQLADPLVLIVLNIDSPQLRSRVHQTAFSVLANARNVQLIASVDHVNAALIWDQPLRDAFAWLHYPISTYRCYENEVMADGTRLLGLDAKGNAKHTMSSLDVFWEATTSNMRKILTQLALHAPSKEKRGVMNSLGIPKFCRILKDEFATTSETALRQQLIEFCDHRLVQVHKDGNIQLLVDRQLLNAFLVLKNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3U9</accession>
    <name>A0A914H3U9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THO complex subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3U9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13901.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13901.t2"/>
        <property type="gene ID" value="Gr19_v10_g13901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13901.t2"/>
        </source>
    </evidence>
    <sequence length="892" mass="100465" checksum="E1EB6EE96C0CB395" modified="2023-02-22" version="1">MEMLKNFTLHDLSKVLQLPDEEFQPSVEPEQRKSLIERFIRSKALKFGGTIPSVVEVNAFVKFVIDAAKQEICSKTITIQVLQDIFDVSTVNCCERLFEIVEDNIDTWKTAFFFDSCKNLVLRMCNDLLKRLSRTVDTTFCGRILILLANFLPFTEKSGLNLTGQFNTLNATTYDREKKEQPFEEVQHNTPIAAAADDDVEVGEIREYRDVTGAISVDYNLYVKFWELQKFFANPNLLFEYNAFKNFHEGLSEILAIFSTNKLERTHTHHKQSEKSPSAPTRMEKNGTSLAAAAAANNDQGGTLPSLRNAKLEPPAEMEMDTSSNDCCPLPVMNNGVTVHDVQVKMEMEIVNDGQGQNDVGTAAAAASDDDDGGPALTCAAAKLDNNSQAAQQHQFFAKYLTSQKLFPLQLADSQFRRYFMLQYLIIANYLLLKVKLKDTFTLTALQEEEVRELSDKCFALLRETHPNGVLFADAVKKVLSRERLWSAWKNEGCPDLITPLLNSQSTTKYAAFKRKALNHFVPGQLDLGNKELSRLWNIQPNNLVACKEMQRKCTPELVQFLEEALDEMDPEQQVDEQYQSVNDETYQWTASRFLLLTSDQYLTCNVQDSSRMPTTTTISTAFFLRKTIQMTAENVPTLKERAEQILSAIKKRENAERARLAAEAKELEKLEKKAAATAAKHVEEDEQQPQQQQQQQRKKDGANTNNGGSARGDEAAMPATKSGRSAAADTAAERKRERGTSGDTATEREKKKGSGDIPAEKEKKRGSARGGETKDTKRAKEQPEEETKRKRRRETEEDTQRKRGGGGSSREADEEIQRKRGREADDETQRKRVRISRDRLIIAISDRSVSVHKKGAQSPDAEEGIKGGNGAKLILARISRGRICVIWLRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4T2</accession>
    <name>A0A914H4T2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4T2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13242.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13242.t1"/>
        <property type="gene ID" value="Gr19_v10_g13242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="630"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13242.t1"/>
        </source>
    </evidence>
    <sequence length="754" mass="84833" checksum="AA5FEBB2AF46C011" modified="2023-02-22" version="1">MESIKISTALAYIVKETCGNGTFVGWKAKGCEVLWDREMLRLQLEGTAKERSELRQAIFNALKKAQLKMEESGKKSQQMVIMEVEIPSNCCGLVIGADGETIRKTKADSGVHSLYIDPTGRHKVNRQPRPNFSWLVICSYAVGPLMTAWARVEELLSFTGKLDPGHREKQATQKLCIPAAEFFSREQTRRFEQIKRTAQGVQIDLDSSDPGEQFRSVTLSGTQNNISSVKMELNMLIDEVKTSMPTDREKHSAYNDSSGEELPSPPELPNGFSDVKSRKEAIGFGKKKTNGGAPSDPVQPRRVEKCKKEVLVPKKCIVHVIGNGGENIRQLQEKFGVKMHFLGNNYLEYPNGRTLSITGDSEEKVESARDYVDKEFILKKWEAWNTYQHDIISAEETCEEICHLSPKFALREDLEFAMKKMKDQSGIVSYCYRQFRSGHRPIVLRGTEMAVEKATKILTKMEEEWSRQQQSTLGNSRARSLDDISITSLNVTNELDELPNDKNGREKAKEERVQVKKSVSAVRETAIDGRDCGGGDFTDDNETLYGSASGEESADDRRRMVSFARNNESASSTIGSNRSMQRQHQHQKLNGVQQILLDSAKGALDKMNKIMESKDAQIRHLEDSVSRILCTECTKSERSVLFTPCRHFLCCQKCAEPLKHCPICKGPSKKRHSSPICSRFGLGGEGYTFWSSLPPCPSPHVHLPSRAQSHRSVSTLLIIPTNGEAMDPSMEEIGGLEFEMNDTQLFRMLREEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H655</accession>
    <name>A0A914H655_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H655"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13586.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13586.t2"/>
        <property type="gene ID" value="Gr19_v10_g13586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13586.t2"/>
        </source>
    </evidence>
    <sequence length="437" mass="47453" checksum="28256D1E31B55DB7" modified="2023-02-22" version="1">MSFGGLFPFTAAAAAENNNNNKSAAAAASFLGALSDNSGGSYHHQNILLTPAVGAEGATAVAVAAALVEGHQQQQQRSPFRKAISPVQQPYISGTGGAKRKLPSFQSERGMQQFGKATTFAASDDDLDDDFKFEVEPRPKRRYEERMSTKLGDIRLKEDECGGAATAPAAMSAQQQQQLHRRTPQFLVESQKQQQHKQREGPLIEDVTDWGVSGDEDLFENGGFMFRRPSSSATPIVEEPDECAGAVDGLMAGRVRHDDEEEEEADELNLDSGCCSSSSSAEEEERQSIELSPELRNLITSMNNNRDGAAAVPTSILRPIRTGKELIPFMPSPVAAVVAAASASIPSCSLTENGRRFQHEDDEQQQLLLRVEEVLDDEILPDAAVGTPQVLSDNEEYWPPTPPPFDGMMTEEDGPDVVKKAVLVNEEEAEEEAMEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7E7</accession>
    <name>A0A914H7E7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7E7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1391.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1391.t1"/>
        <property type="gene ID" value="Gr19_v10_g1391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1391.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9591" checksum="9802012F53E718E4" modified="2023-02-22" version="1">MGRRHFIDATFHRRDTSSTRHFIDATLHRLSKNPTLHRLSQNTTFHRRDISSTRHFIYATLHRRDTSSTKQKSDTSSTKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7S6</accession>
    <name>A0A914H7S6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7S6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1460.t3">
        <property type="protein sequence ID" value="Gr19_v10_g1460.t3"/>
        <property type="gene ID" value="Gr19_v10_g1460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1460.t3"/>
        </source>
    </evidence>
    <sequence length="122" mass="14066" checksum="E3595FCBF4B3C42F" modified="2023-02-22" version="1">MVPGSRILVDQLFVLCGLFIFVMLCYIQPDQVLSRSHEYRVDVSKQPHHTDKVFSEACWRRWTHQSGRFGQQLTRGVAPVSPSIQLVRNAEPCMVETIVRWVAFDGPQKKDQLVIVEMLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H847</accession>
    <name>A0A914H847_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914H847"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14114.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14114.t1"/>
        <property type="gene ID" value="Gr19_v10_g14114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.20">
        <property type="entry name" value="DNA polymerase, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1770.10">
        <property type="entry name" value="TPR 1 domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="240"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14114.t1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50934" checksum="331980734A586556" modified="2023-02-22" version="1">MKNKQREQALELMGKTGIDGTGRSFGVEHLEGVQAFWDKEYPDMFRIVAFDTKRGLKPVFKSENVRKYEVCVISDNGHWDGMKSVSRPERHTIECRERCKNCCRMGFGYPCKKESGPDLHCDACNKDFYSEGCFEEHKKKALPKYRIVAYDMETAASEEREHIPNLISAAHTCTDCCEEKNKECDICVPGPRLITWSAADGIDPLSEFIDWILGFKNADTIAFAQYGGRYDSHFVLTGDAYSGGRTMPFCLFAEASENVEIAMFDIISLYPSVNYDTPYPVGIPKIVKRDEDVLWLLFPLCGTCGKKEKKEFVLAKDEKKCAHNEEERALLGTFTSIELRKALELGYKVTHFYRAYHFEEFDNQLFKGYVRMFLKIKVEASGWPPEVKTEEEKRGFIEMYRAKYAICLDRKNMKKNPGLSENKIIKSADEWVKIMQDDRLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H8L0</accession>
    <name>A0A914H8L0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H8L0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14746.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14746.t1"/>
        <property type="gene ID" value="Gr19_v10_g14746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14746.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37121" checksum="3AE920A0FD5F0266" modified="2023-02-22" version="1">MSDEDCPPAIVMDNGSAMFKAGFAGDEEPRAVFPSIVGRPPRQQGVMVGMGQRDAYVGYKAQNERGILTLKYPIEHGIVTNWDDMEMIWHHTFENELNVEPTEFRVLLTEVALNSRENREKMVEVMFEKFKIPATYVEIQALLALYASGRTTGVVLASGDGVTCAMPINEVPVPVPVSNASLHLGIAGRDLTEHLVNILTERGYSFTTTAQREAVRDIKEKLCYVASDFKQEMATADSSSSLKVKYELPDGQVITVGNERFRCPEALFEPSRTCAGIHKIVHNSIVNCDNDIHKDLYANIVLSGGTTMFSGIAKRGSEEPSIKSSGRPLCTASGDAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H914</accession>
    <name>A0A914H914_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H914"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15328.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15328.t1"/>
        <property type="gene ID" value="Gr19_v10_g15328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15328.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11576" checksum="953EB6DA690C18B1" modified="2023-02-22" version="1">MEQLKEKVIAKMEEHQQAATDHRRVDEKLNVFIDQFSRLQTTIKTWNTSKRMIRKNSYANEIGQQEYALQETVVKMEMYRKEQQQTLATCRRQLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H9M0</accession>
    <name>A0A914H9M0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H9M0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15066.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15066.t1"/>
        <property type="gene ID" value="Gr19_v10_g15066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037918759" evidence="2">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15066.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15117" checksum="54A50D027CFCC1FB" modified="2023-02-22" version="1">MKKFCILILLSFFATNSLDKAESVQLEELPLQTFDELFVDEWLDKGEAEDLGRPSTIFEQNVHHQIDRQNAQIGQIEPNSTDQNPPLTESDHSDNAKSGEEQNDIAEDERKRGNENLAKPHQTKNTPTANKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBZ8</accession>
    <name>A0A914HBZ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HBZ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15670.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15670.t1"/>
        <property type="gene ID" value="Gr19_v10_g15670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15670.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13105" checksum="3B2D318327E06E0E" modified="2023-02-22" version="1">MWKRVKQKKRREGGGGGKEKQQRGEQKGVGERRGNKKELEKEEWEMERKKERKRGKEEKLKRRRWANAAAGGGGMKEGGNFASFDPPLTPKLAQSYLRRQSISFDSSRRDKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCN2</accession>
    <name>A0A914HCN2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCN2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15821.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15821.t1"/>
        <property type="gene ID" value="Gr19_v10_g15821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15821.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36169" checksum="231D5B61AEE4969A" modified="2023-02-22" version="1">MEATIGPSPLRRRLGRGRGVKGKRGRERAGEKDKGKGRGADGKEGKGRQRQLLSHVPGSQSAYVLQLARSLTRPEGKTSVRDSGPTKGDRQRGAMREYAIQLTETRDSQRKQRQERARENREREREYEPSSFAIFSANFGAEFDACGSRCEQSYHSSPSLVPGGGMKRKDTQGTIAVGLRQDAEDDGQFNVSKARGRSVDDVIRSTERRRRLIRALCFRVIRLVVALVPSFFMAFSNACRAAPFQEEESAEEFGGGGKQLIGNRKPHSAKQIMRRRDTSAEQSPYSVAPTAHLEAPMKALFHPMGKQSGERVIRPFPTTPVEQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDS0</accession>
    <name>A0A914HDS0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HDS0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16419.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16419.t1"/>
        <property type="gene ID" value="Gr19_v10_g16419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="103"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16419.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23466" checksum="7C3428A9CEB71DAA" modified="2023-02-22" version="1">MDFLFFAYNLFFGPPSNRRPIDGGTQNSQTVREPDVLADRIIMREQQKAYDKALAIDKQRAEQRKMEERRTREEADRAESKRAFLRQKREEVGATMRREPGGTEGDLVRIRISFPSCAKLERNFRHSDSLERLFEVVFIHQDCPDNFSLFTNFPVKQLNCAPDWYRSAFCADADGSMENDEPIGTFAGAGLFKSANIVVRDNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEE6</accession>
    <name>A0A914HEE6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAX-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PAX transactivation activation domain-interacting protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEE6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16375.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16375.t1"/>
        <property type="gene ID" value="Gr19_v10_g16375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18432">
        <property type="entry name" value="BRCT_PAXIP1_rpt6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="436"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="707"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="809"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16375.t1"/>
        </source>
    </evidence>
    <sequence length="919" mass="102432" checksum="E3C7C07DE900CC29" modified="2023-02-22" version="1">MCEPAAGSSNIAMPGDVAAHQHFGAGNVCVGFGSGSPLEPLDPTKFRNIMVEKHEATGFGHFELAKGVKESVGSFRNTMTAEGELNVAQSESDQQQRASGTFVHPRFPPANATPAFHQINSQQLRESQQQSYFIQQNIQSHYGPMQSPSSASLYGVGGQQMGYLVHGDASSVQPSWNQPQQAQQKPQYVSSQLCQLSSRMLSPQQQQFGIAKPQPSQLTSYPAESGQHTISYPSPHPLHQSSPPIGNVPKQELQHQYQQQILPQQQQQTPRFAAAYSPHQLLSSRPSPAAFHMSSNCGVTNAAMDLRHYMNLTSGVSHTVAVPGSTTHNDQSVQQQSGAQPIKKAQSMFFNASSEMAHQQHIGGGNPTNVTFPSPPATFVRPSPSQDFGGVQHHNKHQQQMLRLPSSQQPSHAHFLQIPSQPQFFGHEPNLAATLNPDICLAGCVFLLVDDCDPHLVDFSLLPSIIRLYGGDIESNNPRGIPERVTHVVCSNWIENEALIQQALTPSFIDRMPRKLKRVVTLNWLNDAIAKRQVTAPSKACHLPSVWSSTRHNPKTFSKVIAAHGFSKRELLELKYMKSDFLVVTKSVFGEQLCQLAARTGSVLVNFQWLLELYFGCINCFTSASSCSPLALSKVCEMCHKLMVPWSQSTIPLHEEIIRLAHQSRENLMSDVTLFPEKHFKISNIAPTDKQIEEATVLYAKSGREVKFVLLFDGLFPEQIENLSRKARFLGAEITSLVALCTHFVTTSLHRTVNLLEAIALGKSVVTPLWVETSLRRLGFVQDLSFFVRDRENEKKYGFNLKATTLRTRNRRVFKGVTFHLSVGVQPKYEVIRRLIEAGGGIVQKEKPKGRDLLQYIQEDRTLFVICDRNSLSSYQFLIDWRFPIFNEDFVLMSILRHKIDISEEFHASPISHCQVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEX0</accession>
    <name>A0A914HEX0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEX0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1688.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1688.t1"/>
        <property type="gene ID" value="Gr19_v10_g1688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF17">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="45"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1688.t1"/>
        </source>
    </evidence>
    <sequence length="534" mass="59014" checksum="AFB5AF533FCBEC35" modified="2023-02-22" version="1">MDHFDDQKQCNATVPAPLVAGGYGDRSSCCCSSVGFRYAILLVTVLCLTTICSNMIAFNFTLILMRRPNWENVSYPADSHIVTSGHWNISADSTSSEFIVLNDSTVVPPTVPYSAIEKSRLLYAVGLASMVSTFPFSALYTRYGARYVFFAAGVISTLATALLPMAAGHGMAAFMVIRVFQGFAYGANFAAIGFVCHRWASLRQHGFFLACMTNFTSIAVTVTNPVAAFVSSTPALGWPWVYYVHALVSPLLFVTWLLIYTDHPECHKCVSDEEKFAILDGKTPDEIEIHGYMPYSAILSNKVIWVVWLNAFADIVTAVFLITYLPTYVSKVLGYGVRETGIWSAVPALLHIPVKIGAGWMADTLTCMNEVNRMRMFNSLALVGSGIMFALTGFVPEKMPFLAVILMTMNFAVVSTNCGGFYKCATLISRQFAHFVVAGIQFEKSVTLFVSPLIFLLFIKDESSHEQWRNVFLGMSVVLVIANTFFWFLADDQPAEFTKEMKKRKQISPELSTERKTNGGENEMSAIVGSPPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HF74</accession>
    <name>A0A914HF74_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914HF74"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16966.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16966.t1"/>
        <property type="gene ID" value="Gr19_v10_g16966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038035717" description="Palmitoyl-protein thioesterase 1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16966.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35791" checksum="658982EA49347165" modified="2023-02-22" version="1">MPFKISVLLPFLWLLTLAANVKDPVPVVLWHGMGDSCCNPLSMGFIQKLIRTNVPRVYVRSLRIGASIPEDIGHGFLANMNDEVAKVCEQLAQDERLAAGYNAIGFSQGGLFVRALAQRCAHPPIRNLISIGGPQQGIFGLPYCPGSAALCAVVRRLLDRGAYTDFVQHNVVQAQYWHDPNPAERYRQANIFLADLNCEQLHCNSTYRDNMVKLRNFVLVQFSHDHKLVPKETASFGFFADNGTPTIIPMEQSAIYKEDRIGLKALNESNRLHLLSFDGEHLQIPTEVFVSEIIEPYLKDKSDDDRGGSVSSTSSESDEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFA9</accession>
    <name>A0A914HFA9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S26, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HFA9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16618.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16618.t1"/>
        <property type="gene ID" value="Gr19_v10_g16618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="Ribosomal_mS26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16618.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19695" checksum="ECA299647D7D51B2" modified="2023-02-22" version="1">MPGKPPILPPSNSKIYKVHQYKWQDPSDIAELLWRRHVYNSAILSMRRLFREEVALKKSLAMGLEEIKAAEAVELDKILELNKLRNITLGEAMAEREKVVVSQIEEMQTRRRTKEVLKTIERSRTEYVTWENLKQRVEEALENPTNFDYAIDLNGVKIPNSLPTKYASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFW4</accession>
    <name>A0A914HFW4_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914HFW4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17139.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17139.t1"/>
        <property type="gene ID" value="Gr19_v10_g17139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="65"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="258"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="724"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17139.t1"/>
        </source>
    </evidence>
    <sequence length="794" mass="89295" checksum="1FE5242D89CC2930" modified="2023-02-22" version="1">MSDLKICEMRELHNNCNGNVEDRRNGSLMSSSSRPGSSMSVASSAKQPFKRIPLQIDRYRKQLTAILHSLDKVAIFIGETACGKSTQIPQLCLRAPWASEGTIIVTQPRRVAAKMLGMRVAQELGSSVGDLVGYKFRFENETSERCRLVYMTEGILLRQMLHNCRLNSYSAIIVDEVHERSVNTDVLLYILRQAQRDRAARAEPPLRILLMSATLDARPLSEYFDGATVYYVKGRMHSVKIFNSPELKLNDNDYLFNAVSAVLELHDTEPIEHGFLVFLTGQEEIDTALNILRKLKQSKSDAAMEEIYAIPLYAAVPTAVTQRAFEPPPRGHRKVLFATNIAETSVTIPGIDVVIDSGKVKRRSFVACNRVDVLRVENISKAQAIQRAGRAGREGPGKCYRLYSLEDYNRLADEQEPELQRCRLTTVLLELVELGVEKVSSLVHLLSPPDINQLRAAVEELLALRAVTLSTTGHLKITEEGSQLLTFPVEPAHAKILLAASELGCLEEACTVVSFMSADPVFQFSGHDLFCLNEKQKFGQEDNTGLSGGLNMKFRTNEGDHARMVQIYRAFTSVKRIQEKMKEFCESNNLNQRRMEQVWSIRKQLHEECMKHKLHFSTSANNMELLRRAICRGLFLNLCRYDTSIQCYVLDRDRKVQVRIHPSSCLHNQRPAAFVFTELMHTNEVYARDISLVQTEWVHESGTDALRDDPKLLERVHCLQMVMPQPTRTPLPSTSAATATVASSLPSPTPTQMPPIKTKRKKRRKMLVTYSTSGSSSDDEKGEDNGRKNGRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HFZ7</accession>
    <name>A0A914HFZ7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HFZ7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16818.t3">
        <property type="protein sequence ID" value="Gr19_v10_g16818.t3"/>
        <property type="gene ID" value="Gr19_v10_g16818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16818.t3"/>
        </source>
    </evidence>
    <sequence length="489" mass="52709" checksum="8B9DF1F065F1157F" modified="2023-02-22" version="1">MLQQTSNGSLISSSSNSQQQLFVGAESLKRQSSAEKSAQCPDESFVGPPALFFCATDAKGTAAGIESFILSGHARVDRCQRPVTDRFAGREQRMDRVGAVPAAGVPPPAPPPPPAQLGPTKILGTGGRPSANRQHIVGVPSTQPPVVPSQERSQPFAGVHPETLQHAAARLRPTQHRESLFPPERQQFLDGQDLLASGRHWADQPQHDALAKHSSGTTLYASSPYPNQPAALRFDAAHRDSLNASPSAVGQQQHHQQYHHSQPQPHYFPHRPSPSSNSPSPHLPYSSSSSSYAFNSSSSPFSSNVPVKEVPIQMVGSQYGTPYSAATKFGSPSPDLIAEPRRHIHAYATQTPVSALMETTPEASSTTSPKWAPNGAGHWQRRVPKGAAATGGDFARELRDAALTERQRAANLQQKSALKQPYSSQLPSSLHNYAYQQTVSSTTTTTSKNANKNGGQAVDELIRDMETKMRNTTNTTSKVILHRPIRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGZ5</accession>
    <name>A0A914HGZ5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGZ5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17274.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17274.t1"/>
        <property type="gene ID" value="Gr19_v10_g17274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17274.t1"/>
        </source>
    </evidence>
    <sequence length="626" mass="69729" checksum="C5ECCB1C165D183D" modified="2023-02-22" version="1">MVLISLNVKTIDGKDSVVRVDDEMPLGHLRNAIEASTGDESCSLNAQGFVDGLAVHVVTKPPPAPPTPNIDNAASQRHQQSEEEMGNLQVITQTLIVGQLLLERTSLFGSPNIAMDAISGVLEEIRGVFQLETEASLRTNLPNESFAVNVVLRANREQTVDSPARERFEALKVEVKKLAWLVALIKAQFADRIDAFFSNQDEPSQQEAYQAIGDILLAMHSFDHFDENTIKGFVERDGDQELITLIQELDSWQTPDDEAHLQTLNQNTIVRHCLSMDLSRLLVILSMVDAKINEHLMSRFNRILSRQHNLQSFSYAARLMNCFSSAFFRIQHARSHIYHSISDMGVHADENGMNRLFPQLLHYERGTEPPRADITLTFIRSRGEPYRIPTPSGEHSTGTATRSSGQPNILPLFTIDPFMTCSSRRYRVFESDSRHNDFWNDPETIRLGIRPPSNSVTASANQQQNGGMLYHHNSGSDDTLVNRMVRHAQMNAQRERFRESVLRVGGNSSSTVGSQPNEQGETAFNNIDDFARFVRQIFHSVVRSMAQNNSSIMPFNSAQIRNAFTANSHVSGFTPIIPSVSSRESGELLMNIGAARGLVTVTIPSEGNQQQNVQQPPSTDSAPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHA7</accession>
    <name>A0A914HHA7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.1.150" evidence="1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17163.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17163.t1"/>
        <property type="gene ID" value="Gr19_v10_g17163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="13">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="14">
        <location>
            <begin position="990"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17163.t1"/>
        </source>
    </evidence>
    <sequence length="1306" mass="146259" checksum="B2E381F7A972DCE6" modified="2023-02-22" version="1">MTSSSMVYFPVFEEPSEGQNNCGTRTSDSSGIFSLFSNLFRPSSSSFSRNDSSSSNNDKMPKNITIDEVQSDQTNCFPLICQMGRSLWRYWMPDSAGNECYECNEKFSTFRRRHHCRLCGQLFCKSCARCQVNGTELGYNGMLRLCSFCAEQVDAHIALRRERREPVKSFAQIETDDVFTGVPIANCSSQENTQYLQYCKHSSGESGVQSERLSFDESFNNSQGGDCFSNSSNRLESLFEQKLGDLLDCLILREQLQLEWRELLWSLSKNVTDRIATLALRSRETLNILDFLHIKKLHLRSDLAPKACAEIVNGVAFSKSLAHSAMPSTMKNVSLMLLNGTISYERVLEKFTSLEPMMAQERQYLRLQCDRVLSRRVSLLLTESSISPTAVELLMADGISIVANVKANVLLRVARTSSADILSSLDAHFLQPRVGFVPEFCQHEFTVADGKCKRMLFIENGGGDFGVTVLLKGRSLRELVAAKRLLRFLVLSRFSTRLELSFLSMFDSVPRNSIPKRGEGDFHCHICELNARYNVKDGPNSDKEDSDFVHGLSSVQLSNSPAIRFSVPYLATSVGRRCPLTASLRGGGPVFRFLRSEDFVELRANFDALQHKLDEVEQAEDEQRRRIGMSMRHRCLDADAMGGEPGRLLNENGWINFRTTSALHFRRRAELNQKAKEEKVQKRTALLAESEANGSELLSRGDLQSDVLNPYNHQGIAFLYCANARRATCRRVEEATRIFCTGPYVLQRQFYHGKDTSLGAFLLNCCFNSDYKCKGCDRPMLEHFRRIVHGNTRIEVVTRNVSSGGGYRNSSTSSLANAAVAAVGPFVNGGMSTAIPSAMVGGGDDELNRTMPLDDLPSAIPNNNCSTIICWLRCNSCSANSSIATMTDEVFHLSFAKFVDYLANGSHWVSPFPSSIDLAECHHCTFHCHSHFFALGNFVAQFSVNPIYPLNVLFAPIPCTIDTAETEKQHEEKELSQIALRDTLDGKGIQIPDAGSIIAHALAQPSESRLPPREKGSSGSLGSFSATMTNGNKFADFVDIVYADDNWQYTVKVYFPEQFERFRSLIFRDGEKSFINSLSSSSPWYPQGGKSGAGFSRTDNERFVLKTLNRFELDAFKHSALKYIDYISMALMERKLTALCKIFGAFTVNATNKKTCQSIWDLKGSLRNRLASTKNDNNGASSVLLDENYIQNMWRNQIYVSTHSKTAISQAIINDSHFLADQGIMDYSLLAGVCRGEEDEVIIGIVDYMRTFTFDKKVESAIKNAIPLTNSSTVISPELYCRRFYEAIDGYFAVAPDQWTSDSIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHJ1</accession>
    <name>A0A914HHJ1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HHJ1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17414.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17414.t1"/>
        <property type="gene ID" value="Gr19_v10_g17414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106005">
        <property type="term" value="P:RNA 5'-cap (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028271">
        <property type="entry name" value="RAMAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15320">
        <property type="entry name" value="RAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17414.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9931" checksum="11A3837B3E63D2A3" modified="2023-02-22" version="1">MIFSKRFSDTDEDYLNALKTVAIEPICISPWKTESTHQRFMENERFSEGRGFAGRGRRGFYNKNNGNFRKDNYGRRQDYHAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HHV7</accession>
    <name>A0A914HHV7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinase kinase kinase</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914HHV7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17654.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17654.t1"/>
        <property type="gene ID" value="Gr19_v10_g17654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06613">
        <property type="entry name" value="STKc_MAP4K3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000031">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021160">
        <property type="entry name" value="MAPKKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF18">
        <property type="entry name" value="HAPPYHOUR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038172">
        <property type="entry name" value="MAPKKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="14"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="15">
        <location>
            <begin position="546"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="343"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="938"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17654.t1"/>
        </source>
    </evidence>
    <sequence length="976" mass="109932" checksum="F59B89C840DCB44E" modified="2023-02-22" version="1">MHNAIRRADPCGDYELLQRVGSGSYGEVFKARDVRSGEFAAVKIVKLETGDNFADIQQEILVLKDCVHRNIISYSGSYLRRDRLWIVMEYCSGGSLQDIYEMIGPLSELQIAFICRETLHGLKYLHQRGKIHRDVKGANILLAHNGDVKLADFGIAAQITATLGKRKSFIGSPYWMAPEVANVERTGGYGSECDVWAVGITAIELAELKPPYYYLSPIQVLSQMTKSSYKIPKLKDKKKWSLAFASFIKSCLAKNPKKRPSPDKLLANDPFVSGALSARLTRELLDRVNHPERFYQTKANGGVGEERLHIEMAVQADPSYATICDQHFELECENYEVPSRRVHSQHQQMIGITPAPTTPPSSSSASSSQERLNFGVDDEDQSYHSERTLLASQGEEQNGESTLLEESLEKNQSVEKKKASGGDARVMKRPRDLRGLLPRGQRPISSASEQPTTAQLKPSRLLARIDESFRSRWIKLRSKSTSMVNMQMSMFSPTNVPLYTRGCHWPSRHHNHQPFQSRPMTCCFGMVPTPQVTMGACFVSVLHRTSIRVNCCAQWFHPANRKQFMIIGAEQGIFAMDLSHFTSEEEALVQLHERRCTWLYVVNDTLTALQGKTPYLYRHEMLQLFQHELITQKLAKSIDKLSQKLKPKSLLSTLRMPETRDCYQCTVERSINNENLYLCCAVPHAVLLFQWYEPLSRFVHLKRLQLDKLNTPYTDLQHAHKPFNLVFRSGTANSDLPMVCIGISRVLTSPVGTAQELLRELRSKPQKDKFELQLVDFNGSDSATNNLNDLYSAGLFGDCSSDDEMGTWQRGGPMASPRSTSSLRTIWRWREKLENVVTLRQLDKETLFIAHNNQILITDFNGTEKNTDLMQTSFTFDFNLDYAIPLSDSVLAFHKHGVVGKSFFNGAVTQDLNDPSKLYKLVGRDSLVVLKVAKCRSASTPSEGNASDLEGEEPSSADGEEHICVLTGHVSTMTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIL1</accession>
    <name>A0A914HIL1_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HIL1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17707.t2">
        <property type="protein sequence ID" value="Gr19_v10_g17707.t2"/>
        <property type="gene ID" value="Gr19_v10_g17707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="695"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17707.t2"/>
        </source>
    </evidence>
    <sequence length="916" mass="102132" checksum="DA314A0410F8C713" modified="2023-02-22" version="1">MHEITIRCEPFTLQFKSISSEKKDLIFCHYIILKQNAQEERGETARLSSFVGACAIGDLVKTTLGPKGMDKILISGSGEHQNVQVTNDGATILKSIGVDNPAAKVLVDISLTQDKEVGDGTTSVTVFAAELLREAEVMVGQRIHPQVIVSGYRKAVRVAKDALEKVAQTSGEHLRDDLLKIAKTSLGSKILSQHSEHFAKLAVDAVLRLGPNGALDSIQGFLLEKKPGMYQPQRIEDAKILIANSSMDQDKIKVFGSRIRVDSVAKIAELEQAEKDKMKQKVEKICSHDINVFINRQLIYNYPEQLFADRKVMAIEHADFEGIERLALVLGGEIASTFDNPSEVKLGSCKLIEETTIGEDTLLRFSGVPLGNACSVVLRGSTQQIIDEAERSLHDALCVLSTHVKDQRVVPGAGASEMLMATAVLAESQKVAGKESIAMEAFARALTKLPTIICDNAGLDSAEIISHVRAEHSKGNRQFGIDVENGRMGDVFELGVLESYNVKLGVLCSGAEAAEQLLRVDCIIKCAPRPRTKDRRPPLIRALLLQSRHAIMATLLMRVLGLAVVFPVFLSVFLYLFVPALFFFCPIIMQHVFFLNFVRVPFVDYYDLAHHGVRSRGRNFYLRERDLKTQKSTVNVGNDEPTIGVWHILPTSLSAEKGTKMNDKDMERSLNEGSNAILIYLHGNSFDRTTRHRCELYNFLSSMDFHILAVDYRGYGDSTGRPDENGVNADAHAIYDYARKKASSKDIYVWGHSMGTGVATRLVAELSDLGTPPKALVLESPFNNLRDVVRHHPFSFPWRVLPWFDATIVRPLVRSGLRMNSDDRIQSVSCPILVLHAEDDHVIPVKLARKLVDSAKTAKREVTYMEFDAKLEYRHKFIHRAPELPEVLREFFANGHLQQRSKNRIQRENEAVHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKB6</accession>
    <name>A0A914HKB6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HKB6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17411.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17411.t1"/>
        <property type="gene ID" value="Gr19_v10_g17411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037894063" evidence="2">
        <location>
            <begin position="30"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17411.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="26312" checksum="00339912E8276A0D" modified="2023-02-22" version="1">MALSLACLHPCPLILLFILVLCPPSGVVSVPLMASDYSHLLRDHSSAQNIQRTKTALNGSETAATPDALSSSAILSATEGDAPTPSISNSSPVTASTTSTPTLAPASNSSAPSDASARLLCQFFIFSTLFGSVCTVSACTCLFHTRRSIVGSSQQRRAASAEDLSISRLARIREPFGPNKPFCLKFDEKGLCYASPLTREVPPLPTYEDACKMLSFAELVANCAADAQRAQSGEETKGRGPPTATTDAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HL42</accession>
    <name>A0A914HL42_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HL42"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17625.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17625.t1"/>
        <property type="gene ID" value="Gr19_v10_g17625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
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        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF301">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="15">
        <location>
            <begin position="258"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="13">
        <location>
            <begin position="516"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="14">
        <location>
            <begin position="873"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="97"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1115"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17625.t1"/>
        </source>
    </evidence>
    <sequence length="1182" mass="134469" checksum="023AC8D9D38A9B56" modified="2023-02-22" version="1">MPAKDGDGTIGFRVPSMQNVIVRWRRKFGLSRPLLIASSSPFASGVGAPSSAPLAHRHHSQSHRFSLSTTSSSCSPPSEVQLFSLTDELELDEVELQRKKNDDDDNGRRHPAAGGDRAADHNTDHPLRQLSMPSASSPTAVSPRSLSMDKRPKSPPALSLSRCQLYCSLSLFLISIFLSQEKTGQEGQAVTAKLVVPEGGIGSLNTGHDITRLRVSGKFLLGSTRQRGNETADAEEALDRKGSEPGAEELRLSGELFPIWYNLTLKVFVPGFGVHISPNLNLTFDGDLLLKFGVNRTTKRIELNALKLRFPVHNLTQYELNRVDDDGAANGQMPKVVGIRVDEAREKVFFELDDELTEGAHYALRIRYSGPIASKLSGLYLTSYTTLSGEHKCAAVTQMEPTDARRMVPSFDEPEFKAIYRLSVIHPEGSSAVSNAKELRERHRNVGGFCLHHASLFALCRELAEWVRTDFDDTLPMSSYLLALVVSDFEYVEGNTSLGTRFRIWSRKDALNLTSYALRAGIKVLEFYEHYYGIPFPLPKQDMMAFPDFAAGAMENWGLVTYREKYLLYSPDLYTAQQKQAVASVVAHELAHQWFGNLVTMRWWSDLWLNEGFATLMEYLGTDAISDGLFRMDDYFLVDALDSAFDRDSRVTSHPLFFEIRKAEDVTEAFDSITYSKGASILRMIRAVMGEEHFKKGLNIYLTRFKYRNAEHTDLWDALTEAVPEGMKDWKGDNFSVKQFARQWTEQTGYPIVQVQRLDDRRVQLSQQRFRMDPDAREMPEAVQNSSVWEVPVWWSLNGKSEPMEWLKDNCILNATDSDVLVINSRSQGFYRVHYSADWLTTHSKPTLPGPQKFVAGLPGADHRRHIHFGRGGEKDYPPWEMALAGFSTIQNYFEDEPEAGPMRAYIKQIINTLFERALPHIKDQRDDEEHFFDNLLRHRIVQRMCTLRDDRCISAILNIYADGFVRPCQSEANLTMSSDCSRIPAPFRALAYCEGIHYGAERDWDFVFRMFRIETVQVEKERLLLALACSRDTHTLKRLLSLAADATSTVIRLQDKPSVFSHVASRIIGKKIVLDFFIDHWNEIYEDFKDQQTLLRSIISSSIVGKSKRVIDQMEQFLRDNERTTKNLDVFKQRLEVLQTNRRWMDRNFAPLAEWFRQHGTPLDNDELFQPIGGPIPSPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HN92</accession>
    <name>A0A914HN92_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HN92"/>
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        <property type="protein sequence ID" value="Gr19_v10_g2168.t1"/>
        <property type="gene ID" value="Gr19_v10_g2168"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10324">
        <property type="entry name" value="SLC6sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF324">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER SNF-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="820"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="898"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="842"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2168.t1"/>
        </source>
    </evidence>
    <sequence length="1035" mass="117978" checksum="F7ACED01D9D3B34C" modified="2023-02-22" version="1">MIFNFHFSIGCPALRFPQKRRKAQLERNWRIPEEKMQELGLFLVELNRQLEGNDFEGAAVIYIKCLAFVEELERLYPNKLIQPIVLAPSNIIPPPHPANFAVLEATKLDSNAPDVATFRPNRFLHFAGKPPERGGSRGRNGVNRRSLWNRITDRGMRKLRDQTSGARADEVRDLWNTQIEFFLSCLGFIVGGGNTLRFPAMIFEFGGIFFIPHLFFMVIFGFPLVYMHLAIGQYSGLSASAAFYKMMPIASGLGWALVLLALPVSIYYIFYVAWGFYYLWFALHGIFEQDGMIWEHCRPEWVLHFNCCELTTMVNGERCGGYGGQAMPAPEAFFYFQVLNRTMDVQEAGLGQIQEHLLISLIISWIVVFFGVFKGLGSIGWAVSITATLPYFLLVILLLRSISLEGASTGLVYLFKPELKNLWNLKLWRKAAEQVFYSLGIDAGPLISMASFSRYRNNIYRDAVLMVIIDTLTSVLCGMVIFSFIGFMTTQQGIRIQDIQRLDPSYIAFTVYPGVTSYLEWGFVWAILFYIILTVSALDAEFAWLEMIAASIMNKFGSKQKRLENRLLIILCVFCFLCGIPLCTQGGIYIFHAIENMNSNWNSFSLSLIQVLIVCHAYGVDKFLEDIADMLRVDRLPSFDVLSSREHFLWRRFLHVVGPTGAYIKWMWSMFAPIVLTLLLIASILGYERVTFNGIKLPIEYELIAWIVMIGPLLIVPVTALYNIWDAKRSNKPLKSVFSGSFRKRELDEEESKQPKHTQQNEGGLYAYIDPLSRGASAKSATNRFSRRSATIFWHKDNQQQQNLAADDEQKYQEVRERLRRWTEEEGSSSIGVQRSLTDRPEIEDDSVEETEDGTEDQRMPGRISDWQRAQQHQQVINNALFTPQDMAMQSFGMHHIQRKDTESATDTQSQSKCESPFLFGPPPQQPVLLGTYTNNKTDIVDDSHNEAGTSDNIKITSQSIVKQFGQSSSVIELSEFSTGLAASAGVVVPCQQHQQPFPFSLSMHSQPDWRTSNLTRQRLKRPQPIAQRMMKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HNR4</accession>
    <name>A0A914HNR4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HNR4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2838.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2838.t1"/>
        <property type="gene ID" value="Gr19_v10_g2838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000550">
        <property type="entry name" value="Homeobox domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040363">
        <property type="entry name" value="HMBOX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006899">
        <property type="entry name" value="HNF-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044869">
        <property type="entry name" value="HNF-1_POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14618:SF0">
        <property type="entry name" value="HOMEOBOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14618">
        <property type="entry name" value="HOMEODOX-CONTAINING PROTEIN 1 HMBOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04814">
        <property type="entry name" value="HNF-1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51936">
        <property type="entry name" value="POU_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POU-specific atypical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="319"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="321"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2838.t1"/>
        </source>
    </evidence>
    <sequence length="579" mass="64849" checksum="AEBB46DA8BD8E988" modified="2023-02-22" version="1">MEEQSTAFFMNSQNISSPLSGNINREQLKLLIQIHGTGIGGRELINAFAELEQQMGGGTDYRKTERRRDENDAEEDAEQHENSNGTAILLLHQLAVAQRQQLEHVEQRSAEEPEEVAETTDGEGRAIGNKFETEFNRHATEQPPPNERNGRIRKNGPLNTAGTEPPLTMGSNASWSPKPRLERDSLPPIVPTACSSSSAPSSSSRPIRSQRTPMKEIITLDDPGELDEFMARGEEQCIHAMRAFITQFSLRQTTVATMTGVSQPYISKLLNGNHRELSLRCRKNIYCWYLNCRRHPEKLAMFMQDPCTRLETTAEGELIPQRRERYVFRPVLLRVLEAYFQESAFPDIAKRVEIANACNAHLQIDKRGAQLMPKEVVTPQVIANWFANKRKEMRRRTGGIAPELGVAQRNRLNSLSGGHRPTEPTVSGLSNSPSSSPNSTVLSYNVHIEQHQKQQHLGSSMEEVLLVHRQNQQQQIVERSVPNGDQPVSSAQSVADLALLLPTFAPSRQPNCTPIPTPSFPQSLLQLPPPVDHIHQLVRAQPSLANQFLLLHQLLIGTLPAEGGCFKQDQQHLLMAHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HP33</accession>
    <name>A0A914HP33_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HP33"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3090.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3090.t1"/>
        <property type="gene ID" value="Gr19_v10_g3090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="36"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3090.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25860" checksum="B61655B0B92DE0E7" modified="2023-02-22" version="1">MANLQIQRRRRLPLELQCEVISALPFQHGRRMLLLCNSIAKNCIALIRKQKEKFENRWDPTACHYKLALIGPEQLIVQHNGARAGSVLAENPMSKNPYFEVESLEQTWTKGFIWIGLATKQMPLNNPVGLDEGTYGYASVGFLCGHEVEESFYGVDGRTYSRGMPSFGCSDVVGCGVNLKNGQIIYTKNGERLDTANLFVDSAAELFPCISLFGHGTKIEANFGPNFKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQG3</accession>
    <name>A0A914HQG3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g3706.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3706.t1"/>
        <property type="gene ID" value="Gr19_v10_g3706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="1743"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="1774"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1627"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1696"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2049"/>
            <end position="2199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2293"/>
            <end position="2361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="944"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1430"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1629"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1650"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1708"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1724"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2072"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2094"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2131"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2182"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2293"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2318"/>
            <end position="2328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3706.t1"/>
        </source>
    </evidence>
    <sequence length="2361" mass="267145" checksum="944DB66BBDD9FDD5" modified="2023-02-22" version="1">MLTLGTSFSHWLYCSNSVSAQHCNSIVHAEQLNQSTAIKRLNKSTNKQHKASLQQKIQAAHQGPNRQRRQSNLGQRVQAAQQVLKAAPTPNKLLNKFKQYNEQALEHQVQAVQQATQPATQQCRGQSSKNWKRHSRFETQLEKAQQEAKHLEIFMDDIREASSAWADLLRKLQAADRDAGDAEFSAFNKKEKINDQAVEASTKLRDLRDLIGTLTVQARLYRSRADKEERDAQSSHAQAFQQNATAPTRNNAPAFSAPLYQFQPIQVERFSGQKRQWPEFYESFKSAIGGQPISKAEKFNLLRNMLGGEARQLVSGFRLEDQNYDVVLQLLKDTYGAPEEHIRALHFELANLKACKSLRDTQEFLLQLERLTRELNNAGEDFEGPPTFLMLEKKLTPAFLRTILNKKGEDPAQWSTTKFRNVLNEAVRKETQIQEVMREYGHQQSAQTHNQSTHAQPHVAPNKATTGRSYNPVPTQREHTFEAYRRHDQAPEQPDRTFVSATVDETRQWHSEMPPQHKHQTIGQQTTQQQQIRVSEHSQQSSPQETGNNQREPPYLCIFCGSNHWHEECQQFKTLQQRLEIIREKQLCFKCLKPNHRAYACSRPNKCYRCKRRHPTALCRDGLNESAHDTTATNERNNYNQGPTQFATAAIDPVNCKRGSKSSNSIKAKVMPQQCNAIRGSQTKALLMTTTSTIFNPAQPHRNMAATVFIDPGSHLSFITKRAARQLNLPVAHTEECHLTSFGARKPKKYISDLVKIGIQCAGRKRLIFNLNALQFLVNDMPVIHLNRLGKTQMQRTKLSPPHSEKQPDIMLGMDVWHELNVHPIKRLPSGFMLCNSTIGKILSGSGRVELTQVSNVTFVGPVQEQTTTTPKRHPAKSQSQSSPPKKRHSQTSGQKKNKKKQPQVRPDSNSTTTNVDPNTTVQGVQTSRQEKERAFLKQHQRNKLLTNTARLRTNATHPAAPQAKKAPTIDLTSDINSNEDKSNSSDVEVIEKSQPITPNRKQATLQSKSTRRSAPYVKQTLGTLMLISIIGLIAMHPIAVVQLAHPTQVQSTTETTADWTSTTARAWNTPPTTTWPQSTTRPWPTLTVPTNLHVDGHSCKTYNDKKETARHDKPHSAKQQIPFRRRLGFDNSSNRQWQLDNDTDAKAICGSGARPRLYCLISVSEVYPSTVVLSGLRVRGTSFSHWLYCSNSVSAQHCNSIVHAEQLNQSTAIKRLNKSTNKQHKASLQQKIQAAHQGPNRQRRQSNLGQRVQAAQQVLKAAPTPNKLLNNKFKQYNEQALEHQVQAQKLEAALQVLTRARTAAELKLLADNNASNLENALRFETQLEKAQQEAKHLEIFMDDIREASSAWADLLRKLQAADRDAGDAEFSAFNKKEKINDQAVEASTKLRDLRDLIGTLTVQARLYRSRADKEERDAQSSHAQAFQQNATAPTRNNAPAFSAPLYQFQPIQVERFSGQKRQWPEFYESFKSAIGGQPISKAEKFNLLRNMLGGEARQLVSGFRLEDQNYDVVLQLLKDTYGAPEEHIRALHFELANLKACKSLRDTQEFLLQLERLTRELNNAGEDFEGPPTFLMLEKKLTPAFLRTILNKKGEDPAQWSTTKFRNVLNEAVRKETQIQEVMREYGHQQSAQTHNQSTHAQPHVAPNKATTGRSYNPVPTQREHTFEAYRRHDQAPEQPDRTFVSATVDETRQWHSEMPPQHKHQTIGQQTTQQQQIRVSERSQQSSPQETGNNQREPPYLCIFCGSNHWHEECQQFKTLQQRLEIIREKQLCFKCLKPNHRAYACSRPNKCYRCKRRHPTALCRDGLNESAHDTTATNERNNYNQGPTQFATAAIDPVNCKRGSKSSNSIKAKVMPQQCNAIRGSQTKALLMTTTSTIFNPAQPHRNMAATVFIDPGSHRSFITKRAARQLNLPVAHTEECHLTSFGARKPKKYISDLVKIGIQCAGRKRLIFNLNALQFLVNDMPVIHLNRLGKTQMQRTKLSPPHSEKQPDIMLGMDVWHELNVHPIKRLPSGFMLCNSTIGKILSGSGRVELTQVSNVTFVGPVQEQTTTTPKRHPAKSQSQSSPPKKRHSQTSGQKKNKKKQPQVRPDSNSTTTNVDPNTTVQGVQTSRQEKERAFLKQHQRNKLLTNTARLRTNATHPAAPQAKKAPTIDLTSDINSNEDKSNSSDVEVIEKSQPITPNRKQATLQSKSTRRSAPYVKQTLGTLMLISIIGLIAMHPIAVVQLAHPTQVQSTTETTADWTSTTARAWNTPPTTTWPQSTTRPWPTLTVPTNLHVDGHSCKTYNDKKETARHDKPHSAKQQIPFRRRLGFDNSSNRQWQLDNDTDAKAICGSGARPVRLPTTTDRRARSKRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQP7</accession>
    <name>A0A914HQP7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3568.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3568.t1"/>
        <property type="gene ID" value="Gr19_v10_g3568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14350">
        <property type="entry name" value="UBA_DCNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF32">
        <property type="entry name" value="DCN1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="60"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3568.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="31025" checksum="98EAC7F935710C7B" modified="2023-02-22" version="1">MNKLKKEQKDKVHQFISFTQSNEQTAIACLTSSNWNLEMACDLFYQNPAYLNQVTTAQQMDNRKIDQFFAKYANDPKDKAQKIESDRIGPNGMVRFLRDLGIDPTSRAVMVLAWKLRAQKQCEFTQQEFREGLTTLMPTGTLDAKNFRNALIKAEQETVAERQKFRELYQFIFKYVKLASQSSLELETAVACWEVLLGDRDHRAGMWVDFLRARKVKGIPRDTWNLFLEFLEKIDSDLGNYDAEGAWPVLIDEFVEWCRKRTIEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR64</accession>
    <name>A0A914HR64_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR64"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3705.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3705.t1"/>
        <property type="gene ID" value="Gr19_v10_g3705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036688948" evidence="1">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3705.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22883" checksum="8B68C8923346097B" modified="2023-02-22" version="1">MKEFWILILVAFFATNSLDKAESVKLELKTFDEIFGEGWWDKGEAEYLKTPAPTNFGQNVHHQIDRQNTQIGQIEPNSTDQLGQIEPNSTDQNHKTVAKELGLNYVTISNWKSELGQTASNKSPHSEQKKLMERYYKIKDKNSKIRDEEIAKMLKIGSATLYRWKKQFHPNSVDSVEENAAANVQEIGHKNSGSILMKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRP7</accession>
    <name>A0A914HRP7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRP7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3620.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3620.t1"/>
        <property type="gene ID" value="Gr19_v10_g3620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3620.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22009" checksum="B14A5CA28867F89B" modified="2023-02-22" version="1">MAPSVDPLYELYMYKGLVPREIASFGIIAMICCVGIGLNSSLVYVTIKTKPVTCILGDPSNQSENHYFTNISALVIYCGDFLCYTLIWLIIWRRKSLIPKNVKKLTISLSVFMSIALICYILNIFLYAIITPLLNLDAFTIEYFVLPISLVLQSMAYGSSAPVLYFCNGQYRRAFRKQFGHQEQQVAPVQYLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HSF5</accession>
    <name>A0A914HSF5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HSF5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4232.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4232.t1"/>
        <property type="gene ID" value="Gr19_v10_g4232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4232.t1"/>
        </source>
    </evidence>
    <sequence length="880" mass="100785" checksum="8C986FC23CB4AF74" modified="2023-02-22" version="1">MESIHRSEEMCLAQLFLQKEAAYACVAELGELGLVQFRDLNEKVNIFQRKFVTEVRRCDEMERKLRFLETEIKKDGIPMLDTGENPEAPQPREMFDLEAIFEKLENELREVNQNEEMLKKNFAELTELKHILRKTQQFFDEVESERRAWFASSQRTTSAQVESRVDDAEQPLLGVEHVREAGSRLRFGFIAGVILRERLPTFERLLWRACRGNVFLRQSEITEALSDTATGLSVQKAVFIIFFQGDQLKSRIKKICEGFRASIYPCPETPQERREMSIGVMTRIEDLKTVLGQTQDHRHRVLVSAAKNVRMWLAKVTKIKAIYHTLNLFNLDQKCFIAECWCPVAELDRIQRALRAGSDESGSTVPSILNRMETSEAPPTYNRTNKFTQGFQAIVDAYGIANYREINPAPYTMVTFPFLFALMFGDLGHGFIMFAFALFMVLKEKRLEAQRIKDEIFQMFFGGRYVIFLMGLFSIYTGLIYNDAFSKSFNLFGSSWHNPFDVDTLLDENPEKLLQLSPQQSYASSPYPVGVDPVWNLAESNKLNFLNSMKMKASVIIGISQMTFGVALSYYNHKYFKSDLDIKFTFIPQLIFLSSIFIYLCLQIVAKWLFYDAQGGHTVFTYKYPGAICAPSLLIGLINMFMMKSRNKGFYREDGTIDPACHLNYWYPGQSFFESIFIPVAVGCIFVMLFAKPYVLWQQRQQRRALSGVGVHNQLSVHANMQEDGAEVLHHEDTSKQAVESGQHGANDESFGDVMVYQAIHTIEFALGCISHTASYLRLWALSLAHAQLSDVLWTMVLRNGFLQSGYVGAVLTYLIFFVFATLTVSILVLMEGLSAFLHALRLHWVEFQSKFYGGMGHAFAPFSFEKILEESRNSEESCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT22</accession>
    <name>A0A914HT22_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HT22"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4208.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4208.t1"/>
        <property type="gene ID" value="Gr19_v10_g4208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="4">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4208.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="33326" checksum="02059A495177DEC6" modified="2023-02-22" version="1">MEVELSSSAETPKPIGDEKTSSSFKELVSASFTSMGSGPSFNRILNGVKVLSATSPSVLVELTLAEEHTNDMGLMHTGFTAAMADILTATAVRLTAAQNTPIVSIDLSVTYLQPARIGETVLMEANCLRAGRSIAFTEAIFRRKSDCEVIVRASQQLAILHYRLPPKTKGEDETEAKTGPQSDNKNSTELPVSNGFANVQQSMALSAGCKNFNRMSKNLKVVRAEPLAVEVKLEFEHLNEGGTMHGGFVASLVDIVSVRAVDLAVPNCQLVSLFVSISYLLPAKIGEEKQRSAERATERCWPKASTTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTV0</accession>
    <name>A0A914HTV0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTV0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4410.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4410.t1"/>
        <property type="gene ID" value="Gr19_v10_g4410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4410.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11668" checksum="21741C1204AEE615" modified="2023-02-22" version="1">MALLCAAEPDCIVPIGQTVFCIYTPIAPNLVCHRQDQSLLGILRHNMEYRLEMEDPSFLPQISRDHPRGTQNYGGMDGLFYVSKRQKFDGSNADWLYKVRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUB3</accession>
    <name>A0A914HUB3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUB3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3839.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3839.t1"/>
        <property type="gene ID" value="Gr19_v10_g3839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009689">
        <property type="entry name" value="DUF1280"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06918">
        <property type="entry name" value="DUF1280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3839.t1"/>
        </source>
    </evidence>
    <sequence length="704" mass="79912" checksum="77A0B2AEE855310C" modified="2023-02-22" version="1">MSDKNLLHKLHAEKGAQKRWGKHDKRRASAINAINARWAKKHRDNEDDVALPPPDAGDDTSTAAPVPEIVEEPPATPALEFNFCPPPAEVTPPPTTPGEQPVEERLLELERQLRERDDTIGFLRLQLRNREAVIADLRSQLPSTSASTSSQITPTRGRPAKNVDELKRSARRELADKLVAVLDRDRSRSASRNGLERLHREVRHRFQHFTPLKKEAQPADEPMESEDALVILSLLGTQKAYRRLKRTFRLINHQFDVLPPIKKVIAIKRQICEPLHYQTVETPAGVGFFCADIEGALKFRLRSAKDNLKYIDPNVLLKLSGDFGQGFTKITISFGEAQRPNSPANNFVAAVFPAKDSRANMEVYGGTLWEQIGQLESLDGRRVKWFLGGDVSFVWGIVGHCGSARTSFPSPVCTCSRDQLLDEDMCRLRSVTETVQQAQQFEQAIQRGESATKALRSATMGIVKTPLLPAIDFDRIVLAPFHVFQGLGNALVRELERQTACETTVQQFLRSIGARREKFRKKDYTGNTIRKILLRAAEMVPLLTTEWPKTICMALAYLAKIQAFSKVQPLLPREVAELEDHMDNFKAFIVDQPQMRLLLSQKPKAHLLLVHFVPFARQHHFLGLMDEQGDEALHSVWRRLEQLWKTMPDVAQIRQQLEHQFIHNWLLDSGKLEEMELRRMETESTAELGEDRMDDEEDCFAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVB0</accession>
    <name>A0A914HVB0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVB0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4818.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4818.t1"/>
        <property type="gene ID" value="Gr19_v10_g4818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4818.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11164" checksum="0085246B5A562413" modified="2023-02-22" version="1">MNKVEGKKLLQHRRVVDNRWSGGWVSFRRKGLPDNEWAVGTHRQMQPSLSTTTTSSSSSSNSFIPWGDIDRKGPLKRLEELPTAAAAAAAAAAGWWWWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HVE3</accession>
    <name>A0A914HVE3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HVE3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4845.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4845.t1"/>
        <property type="gene ID" value="Gr19_v10_g4845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4845.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26453" checksum="42A4A7221AEC12FD" modified="2023-02-22" version="1">MNSSDSEESLIEGEIVSESESEEGEFHSDQEENPMEAPHRIAETCGPNFAVRNLRSETCGPKLAAQILRSETAARNLLSKTCGPNFAAQILRSETCGPKLAARNLRPETCGPKLAAQILRPKFCGPKLAARNLRPETCGPKLAARNLRPETCGPKLAVRNMRPETCGPKLAVRNMRPETCGPKLAVRNMRPETCGPKLAVRNMRPETCGPKLAVRNMRPETCALFKYGCVRARSALVMLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWC4</accession>
    <name>A0A914HWC4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g5089.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5089.t1"/>
        <property type="gene ID" value="Gr19_v10_g5089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="11">
        <location>
            <begin position="423"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="511"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="767"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1237"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1245"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1270"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1289"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1316"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5089.t1"/>
        </source>
    </evidence>
    <sequence length="1347" mass="147815" checksum="E3B10505528EF8C9" modified="2023-02-22" version="1">MYGSENCHRQQSYTNREKDREEFSTNSTATTSAKTSDFCAVGKLSITEGFVSAPTESKQIALSAGCSGNCSMRDSLSAAGSEGHLCGYGDDQSEDQEKIGRIPLSVRCHCQPLPAHYGSTSTTFSSESSNLTNSSFGGASGVRQLHHDQSSVASSSGVATMSSTDHLPMIDSAIVGSLSSSAHSPLPSRSSADDSTPTISTLSGGATRLRRELGPLLGGAAYSLASSGSVLSNTAGSVAATAFSSLSLSTPASISSLSTPGPAAADLENKYNLTPMHNADKTTVGVKCDTNGLLVSHSQAHSTPSLIGTGTGASGWRKQLDPATSFPGCNGSFALGENQQSQKEERSTENVETSSSSAGMTASGVVLTNPSTSQAGPSTLPGQPLPQLGLTTSPLPSVFNCAATSCSQIICTPLRTIVSQNRRRYQMDGFNLDLTYITDRIIAMGYPADTREALYRNSMSHIVRFLEHYHPGHYKVFNLRGHYVYDPANFHNRVVSYEMTDHHPPRLAFMAPFCREVHDYLEADPKNVVAVHCKAGKGRTGVMICAYLCYISFYRIPRQNMDYYSIIRTHNNKGVTIPSQRRYVYYFSHLRKRKLNYMPLRCELVGVYLERPPKLSGPFSKGALKVRVALGDVDVFLGNELWLDGDKYEVEEELHKRFPLMVGEDQHDPTRPDPHKTCISRRCFGWTVPENRRVFLEGDVRVDIFQKSQLKLFNVKQERKKIGHIWFNTMFTCPGFCGGAYVHGDEAYSYPESMIVRRCHKRLRNQKIDEPQHRVQEQTEDSNSEKEDTKSRENGVGASAVSGKKRSTRSPCRQLIEAESRSWQSQDGEDRQQKIHQSGARASLDTVANVSGGGIDGSEWVEEIIVERPPGLTAHCSEDSLKRIFPNDKLAPRHGIEEMIREAFHKNLISDSYNTRRISQTRGEGQPIPKAPVGRPNADGPLCLIRKPDEHVSVFGVQEIDRAYKNKDIDAAFKLFIVTRCVDESAEKNVLLAEQHIAATRQKQAQKDKEKSNKMEQKQRKLGPASSAAAHQHVQPASQLDFSSVLADFSHASCSSSSSIAVSSCASSLSSQSQLTSNFATPLMTPGLVTHTCEISSSDNDSLLNPSIHMFIIIAPYSAEAITNSTASHRRRNSASGKLLAFCPTTATEVDEEELGGTDDTSFADFDFFHPRQTTCSTMRGDVADVKKERVGRENNNLSASSSVSTITAMTRTKTLSNEERKREDIVHKKQSIANRESFTRKKSCQQLTEKGSVVSSPLSDQTEPEIYHPSDCSLAPSSSSCSSSDSLENQQQPQSSELDSGDNRGRNILQPHNQYNHHTHQHNHRHRNRSSHKSGDSGSRSSRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HXY1</accession>
    <name>A0A914HXY1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g5140.t3">
        <property type="protein sequence ID" value="Gr19_v10_g5140.t3"/>
        <property type="gene ID" value="Gr19_v10_g5140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029602">
        <property type="entry name" value="IFT74"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1761"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1943"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1978"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2066"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2176"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2337"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="616"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="747"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1354"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1540"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1958"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="873"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2109"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2269"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2425"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2526"/>
            <end position="2550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2893"/>
            <end position="2927"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="183"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="345"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="560"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1068"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2270"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2290"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2526"/>
            <end position="2544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2917"/>
            <end position="2927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5140.t3"/>
        </source>
    </evidence>
    <sequence length="2927" mass="327046" checksum="B9941465FAB14CAD" modified="2023-02-22" version="1">MDTRPPSARPSTRQQPQRPGTASVRRPKTAGRNSERPLSSTGRPLLPQQTPISANRPKSRMGLAGGEMIGAGGHRPATGTVGASDGNGAPLPKSATDSLRSSSRRGLHSAASRHNAMFPAGGSVPVPSVGGPSMQQRPITQQGISGAKAVVPGSRMGSRLGTAMRGRMVADKSYFIGLLNNQLNALETEIVSLGLELQKAEKGRENLLAYEQRAEEQANELKQLQGGLADYNLIISRQNTNSDLRMLENEVVEANRINREMVATVEGLFRERKVREEAMHELEQRIERMKAENTLKLSDMEREVKEEFKRVSAEAETLAGDLSKRQTELEELCRRKEEMDLALVNSPLKKQAMMLEEQLQELRERRMAILAELNSEETPEVQREHFAQRIQRDNEEISHMQTQLQEMKERLAQSQEELQEFHNEFELLAGDKSEKFRELKNRELQMDSFLESFELSKSQRESQIRALSAQIVRQLQLISLNCRHLEMVMTNVSGLDESVLALGSAGVSAAELQELHVRLQEELITLGQNETLLRTELASKRSKQTEIDSIGRMANSETLREELGTKSREMEAKRAQLEEELTRVDAELAMFREQRGAEQRRLGQNAQIAKSHAQLVAHPRVLFLDEDWPVGKELEVKICDGTEKDELNNGGQQKAIPFEMHLVRRGNENGELADQFSVVPVNESCFTLMLNKQLEADLPLAATVEGPLTPVSPSFSLLFERNDTGDRASLQVELVDVNDNPPRFLGGPFPVELIVPEDSSPGLLLHRLEVVDPDGGIGGICRFSFDRTTNGNGTEEFELFTLDSQQCQWSRCSANLRLNKRMAKGDLAKVRVKARDGAGLTTRANEAVAELEVIVLGANDGGWKAGLTNEDKVEGLGVGREETEETGEEDNNGMDSSLKVTAMSTETSREAYSPLSSPSRRPPPSSSPRSPPAFRTFVVNNLSEDAPDGLELLRLTLPSDQSFHFVMLNSNGLRMLANCSVRVNAPLEVQKRGEMVAEVRRVEDDLPVVVIRVQIWSMISQFQEWMDREIPPNGQIRVEMATGRWVRVLTLPEELYKYAHPTRKKRKGEAPEGKGEAPGRKGEAPEGKGEAPGRKGEAPEGKGEAPGRKGEAPEGKGEAPERKGKAPEGKGETPEGKGKAPVRKGEAPEGKGEAPERKGKAPEGKGETPERKGQAPEGKGETPERKGQAPEGKGEAPEGKGETPEGKGEAPEGKGKAPARLGRSLCVRLPVREWRLQIHWPPEGFLRLTFPENAPLPPVLLQPNVSIYYPPLASPTFSLQNDFNDRAKFYVDPNSGKLSLANRSRVFDFERERFFSVGVSVCVTTAGRRSGCQQIVLQMDVLDSNDHCPQFEDPQANQTETIREDSQPDLTLPIVHFPPAIDADGTDQWRSICYRLVNSFGQTFAIPNPEKAELFLLKALDRETVSSYALEIEAEDCPWTRQRCFPSFSPSPSFSPSPSFSRSPSFSPSSSFSPSPSFSPSPSFSPSPSFSTAASLSSTPPSPSSSILRLSISVSDVNDNPPRFIRRHFFAPLIDLAVKPGDALVRLRATDADQGDQQKGQLKFMWGERTVQTEVDPIPIAVSPFRLNQTNGELSIRNDFDETMSFQRTSFTFRVRVQDSGAKHEDQASVTISILDTSVHLAQLNFSADSTLLDDGRDLLEQLLSIAIGHEWRVLNQKLSRCGGNCSRMSAYFLAKGTFQPIGAERALNELRTAAKKGNEEQRRALNALRDRFGLTMADNAKIPGHFPSGGRSHRFPNIPLVLLSSSFVLISLILFVLFVCRRRRGKSTRRERVHALRLVGPPAGSALCWWEAKGETIAEPATTTSTRSFSRQRRPMGEHFVPVPHIFNGDGVLTNSAASVGTLPLSIPRPLLLETAITFFSLTERENGPRRVNGSEIRGSVCGARKLSNPFIQQSWQKQSDQKQLTTAEPFQISTHNDAKMAAVLFCDVLGALCILLNAFVILALLRNRRRVLVNVFYVLVLHCAVVDLIRGACLIAWGMPHLLIHTMRSIDDRLFALKINQFTLVILRSCNLLTIFNLLVFTTNEFIVIKYPLHYRRYFCRRTVVFVLAIWFVSLLFGIGSVFANFLESVHNVLVEMNATVSPPFEQNEWRKAGDGEEEDEDELPPKGVTGSPFEQNEWRKAGDGEEEDEDGLPPKGPNGVQRRQMAGLSINGLFMLMIFVLCYVCLFTVLICYGKILKTIRQFQRHGGDGRRRVLTNSAVGSQKKPRNRTAGGSIYHKRSVHQQRNHHNQQKGGCQGVVGGGEQLPTEVQSSSNRMDSLSKKVSIPGTPQSRGSRTNCGRCPNCEANPETEIGRSRRCNSHRKWRSHLMSRHKYLIVIGTVLFVDILFLFPYSGIQMVALLHLNNLLATSHLTTLIRWCLQILIGVHSVCQPLGSSAGGSIFGGATAGTISRSAKSIGTMKAPILGGNENGDTDEQPPAKTKRSIVLRTVVSQGMPPRGIMKLAEAGERQEEMTNWANPSVDGQQMLLITQRRRWRRNLSLLCKEEGEELELFLAKEYRRRGVEEHGKGESGQEESGERTRKGGCWKRKASTDQKDFDRLQRRVSLLVSLRWLKVFGREHSDRIKTFIVSRTDAKVHAIRSPILVGLPKGCEWFDQSELTRRNFLDYFNDQIQNAGYAGAVELLRIHPVALGFHPSYHVAYRLVCKKQKLYSFNFGRYVYRLRVLSPEQSRNYPDRFFTQACHLIPNKTSLDDIAEYHYSWTIPPTFSVERAQIACDLLMKPGQNFASFYFHQLRLRKMDKQYKSVTRRRQLSLLQIEKGEPYHFADDEAQFYNLNFIAHGFMRQQIRRMVSLIVNIACDTSGSDPRRIYEFLLRDPDPVRFHEARLVPAPSSGLFLTDVVYDPKMFTKPMPEYLSAWDLDDCEEQVVSECADDEPLEGENTKREEENGESENELDKKYALESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYS8</accession>
    <name>A0A914HYS8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914HYS8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5910.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5910.t1"/>
        <property type="gene ID" value="Gr19_v10_g5910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="204"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5910.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40600" checksum="3FF80615E5550E78" modified="2023-02-22" version="1">MDLETRITKHYTFLMVCLSRPLQVIVKRGGDALWKEVSCKKLPKDHQTSLMSRMPFYFLGIPTVLAAGGYFAMAQYEFNPNSWIGVQARKVITFLFNPSGQSQITNAKNQTMTRYKEIIDMEKAARRESKESEERELTVSELREAAEKYWEEQRRQDLNEDLRGTYREQTNMMIVMTSENEGAVPAEEIKNLIKEPDEATNGFYFQQTMYRIQDPRKSVPFYTNVLGMRLLKQLDFPEGKFSLFFMGYKKSDEIPADETKQKKFALSTHSTIELTHNWECDPNFAGYHNGNSDPRGFGHIGIAVPDVYAACARFEQMGVKFVKKPDDGRMKGLAFISDPDGYWIEIFNPNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ39</accession>
    <name>A0A914HZ39_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">5'-nucleotidase</fullName>
            <ecNumber evidence="3 9">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914HZ39"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5123.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5123.t1"/>
        <property type="gene ID" value="Gr19_v10_g5123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.340:FF:000001">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01544">
        <property type="entry name" value="HAD-SF-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5123.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35887" checksum="3ADEB0E210B09745" modified="2023-02-22" version="1">MQNNAIASELAVKNASKFVSSLLNHPTVTVRMRDAKSVEEKLAAIAGAGCEKLMVISDFDYTLTRYHRNGEVCKTTHGLFVRVVEKNLEFFEKARALETKYKPIEFCPKMSMCEKIPFMESWWEESHQLIVEQRFNKQILKSFVRHSKIHLRERCVELLKKLDLVKVPLILFSAGIGDIIEFVLDEADSHKLSNVHIIANMMEFDENEICVGFSDPLIHTFNKNQSVVKQEAPFFHQLADRNSVLLLGDSLGDVNMDVGVENESVVLKIGFLNFNLDTLLDRYLDDYDIVLVDDQTMEIPLCILEHIRQSTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZG8</accession>
    <name>A0A914HZG8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5508.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5508.t2"/>
        <property type="gene ID" value="Gr19_v10_g5508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="11">
        <location>
            <begin position="1374"/>
            <end position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5508.t2"/>
        </source>
    </evidence>
    <sequence length="1658" mass="193008" checksum="1853E633608B82CD" modified="2023-02-22" version="1">MPTSFKARAPIFDELNLGKLRAQKTANKIPAKNHRPNCPSVNIVIISLFVTAPIILFAVMIILLIAFFNSILFQLFFCKSPSKLTFGINYQNLDAEYCRLFFDANLDDSDQMEHSARLGAVLIKNEIDLDLVNIDVIINQIFLRKKKVLAVPPSIDKSILNAKFKKIKAKIEKKKVGEKFSLVEICKLRIFGMEMKEIRDFLLKVGHKFEEKDLAHLTKLYEKGSNSVECKQLEKVDDFFEKNESEMQIWMFELRNFISQLHSLKLDYLFSNSDDAQKKNFSIWRKFSVRIDGESELSHKLRMLNGRGEIDQIVRIKQKMNRYLMEYKYIGMLELHNPLTMAFDIMGDKMLKTTFRTIVVPADGHQMAAADEITLHNKIWLQISLLCGKIIDYFVQQIHNAKVESANNEVKTDKIENYWKLFARLLGLFKKNSEFDDQKLLLNKFVTLLDYLKGQFGEHKMNLKRKLVLDRLENCFLELYDEDAEFREFLTNDNLPSMALLKEIFEIAKEKDELISEQFWFFITNNLLEYKESNKSSKEKAQMLEDDVTETLQNRIVLLPDETEFRWSESDCSNANVHEKVIKALLKNKLTLAQFHFVALNTLLRRFNEIRHFFCYGMDQINNILLKDRIQLALGDKVLDALELAHPELMHFELLTFSHNYLLFLRQLSHKTGSLKWHIITECQQEGIVKAAIAEQRRRIRKKTLEFLWKSSAKTSLRMIDPIRAIPGGMTRLWKTLYDSEKTAEQNDDDISALRHLMDSSKMMPDYEDVGLLISHYEEALLSDHDKDRIQGKMKAEFLIFFNWINDHSTISFPIMKKIRKYFSKHFQMLNEFYDQIFDESEAEVEQNEHYLVDLIFETKNDVERIMAGQSPNGGTETESAEEWRKRNFHRIIGGKRGQSLEKAKHWEDYLPWMRELHGLTLPNLIKTNEHFAQKLKTACESSLSETNKENENMHYEEEIGERKEIIGAESTSKSVETKAHSKKLDPKEFAGIKLGDFANDNFLALKYGELMAIILREGGHTTEVNSSRMSAFPKLEKAGDENSENYQNCNTGDGADSLARLLDIGALANEIWHYVQTIKALNESKIDSASIASSQILDGPLSQQRILGKFGQNSTKNYFKKIDKYLIFNKKLNEQRNLDENLLEEYKNNSIIKLEKVSQIKNHLIANGYLSEDYKIKSQQVISELSNIVEKWSPEALIQFPRFLFEHKKLEPICILPDEFERELIFGKLNCDHSKRENCGDESLYCSLCLHSGVKLIKKVMISAAPPTLEITFMDVPIEMAFIMVPNVKVPNSGKTFGLKTYEKFAKIFEENIESLLRAAHFDEGMKAKAGLRTLSNCLINEKILEILSPVRNFDNKIDDQMEAEFNVTEKLRIVIAYLELWAKSNYIYGKVMGYLDTPMLLTMTAKVFLMFPKASIPFLIEKYFLIYSKWNWPMPVQLTQIDQKRIGEFMSWAPNRERQFESGKELAMAIISPLFPEQKEAMQINLSTAKIIQIELKMAFAQIRKVDNLQALLEPIMVNGRTFTEKYEHFVTFTCGGTELNVENFCHFVGKRLRHELLYFVENSLANWVRFCHVYPTCVPVELSDDQQTRINRPTTFNKMHKKVWLVGLKLRQQKKKNNDAFKNEFKSILGQLFYNVQLNSEYVEEKHQLPKWIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZL2</accession>
    <name>A0A914HZL2_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZL2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5243.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5243.t1"/>
        <property type="gene ID" value="Gr19_v10_g5243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5243.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="24779" checksum="B43B7B0A423C860B" modified="2023-02-22" version="1">MSSLADFVNEQRKFFKPGNLNGADDAQRLTEHDSAQNGQLPSGRNRKYSWMSFSSSSVSASLSPPDSNPCGLTRFQRIAAFFLCIFAAAFCFITAMMLIPVLVLQTRKFAALNTLGSAFFIVSFGFLWGPLAYCQFLFSEPRRVVTAVYLLSVLATLYTSLWLQSALLTIITAAVQSFGLVWFLLSYVPGGENGLKWMGRMAKMAFCARQSSTLIHTKRGGGGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I0S0</accession>
    <name>A0A914I0S0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I0S0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5809.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5809.t1"/>
        <property type="gene ID" value="Gr19_v10_g5809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5809.t1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42889" checksum="49986C7650FA8244" modified="2023-02-22" version="1">MAPCELRKRMVWVCDDAMFDLLHFLQCADHRHVNLVSRRFRWLSASVAQRYPPRVIRALLVTGTIPRDQQKDGQRLSNSASDQLQLFVGNSISACPLVGPPYAVDFATVGPPATISRIAELEISDFIGPQLIQFLRVSAPLLDECCLIFDDFENFVQFHSVKFIVQFFALFPTNRSVELRFASSLTAPLFIQRPSLFECTEMGIECTADFPLDCLQGWLCQDEALEEGKRKRYLDIRFCVFVHVQHCLTAVQHFANSLRRRFLNAANCCPFIVEIELFGGPHIPELDTFTERNERTEECLAFTRDHLVRVYFLERRKRSIDDSGEERGGGDDQIDEGLGADDAEVVGSDLDYDEHALSMHRSVVFIRQITQGDISTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1C4</accession>
    <name>A0A914I1C4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I1C4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6384.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6384.t1"/>
        <property type="gene ID" value="Gr19_v10_g6384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013">
        <property type="entry name" value="THAUMATIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013:SF2">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6384.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37280" checksum="EC8BABF29AF24D07" modified="2023-02-22" version="1">MNSGLVTLGTVGMGAMLKKMGPLFWKMPANGIKYLYFATKATRQLAKIQSLRFGGFFANDLINKTVAFHIFSKADTLLENDFQMALRVLYRALMAPEPTILAFNTPDTQNAATEEPRIPILPSSTASDFDESSSCNGTSCVQLNLVNGCPYKIFVGRCCACEFDGWHNKNKKCAGSEQITRCATWQRLSRQFLFLNGPFDADGKQTFDVSYVDGANVPISVHVPNCSHGSVIYDYKLGNSLDQLVDAMPDAMKMVDLNGKKRVKSVCLAYGTDSVCCRNAHDQPTTCGPTHNWTTDQITGYNAMLAAFPTSYSYAYDDANATRVCWHGPNFRIGFCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I2A7</accession>
    <name>A0A914I2A7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I2A7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5954.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5954.t1"/>
        <property type="gene ID" value="Gr19_v10_g5954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5954.t1"/>
        </source>
    </evidence>
    <sequence length="501" mass="56457" checksum="D47BF7B62018A705" modified="2023-02-22" version="1">MRRSRSRSKSAPKIDHSKIEVFKPDAPKNSQTRFKEAKRVFQNKRQRDPLPVHVDDDQQILDVIPPHYFQHDDVDVGADEGTSTNRHQLQVPVELRHVIVIDSEDDDDFAAVHEQRKTEHFTPRKAQQRHVQHGLCGQGLPFTQRPVDPRRQPNDPRRHQDGQVQATRRPSDPRTPMGNRIGQVQVGPFGQAMPPSGQTTYPRSSMRQRQNEHEQGGASSSQRPRDPERPMEQTPQRQLSSTFQCGYSTGWASVPPTNRTPYAGQNMSRAFCQTTRQPSDPRTPMGNPIGQVQTSSTLATQTQQQNHQRMSRPTMRGQQSPGRVIVIDSEDEEPAMKRLERNELDNVPGSSFSTAPLANFATATGLGTVPAATAPHWVDAQIALAKDIQQHFVLIEHKMKKCAEIFAQEHKMSFHYVGSASCGSDSSRNHLMRLDPHMIDSNFGTKAGNPVSKISGFNREKAPSCYLDVRSIQRAWLTIFTRIIDESYMINPIACHNCQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3B2</accession>
    <name>A0A914I3B2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3B2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6440.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6440.t1"/>
        <property type="gene ID" value="Gr19_v10_g6440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="72"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="390"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6440.t1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60121" checksum="812BBFCA6D3714E5" modified="2023-02-22" version="1">MINRFIRNFLNGQHIIHKIRQVQTVRRTFLHQCIKNERPSAAVLSLGARAAFSQSSFADLGNHVLEFAQDPQGSSFIQQKLKRASPTEKAQLVDALRGHVVTLALHKSGSHVIRAALESVDKTSQIEITNELSTQVLLLSLHEYGNWVIRSLLDHCTEQQKCHVLEQLHGNVLSLVTDKYGVFVIRHLIEHGLPEDREPIMRSLQENVLSLVTNKYGSNVIEHLIEHGLPEDREPIMRILQDDIMKYAQDKFASNVILKCLICGTAEQKKALFDNVCGGGPQTLQNARQLMADEFGSHVIEKFFEYGTDDQKAQLVDALRGHVLTLALHKYGNHVIGKALETVDKASQIEIINEISAQVIPLSFHEYGNWVIRCLLEHCTEQQTRHVLEQLHGNLLSLVTDKYGNHVIRDLIEHGLPEDRESIVRSLQGDVMKNAHHLSISFIIDKCVVFGTPEQKNALIDQVCADTGSGKSPLLKMMKYPFGNKVVLKMLNVADSARRQKMMLIIKTVPIKSTPNRSPESLTHTVQAQQRGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3H6</accession>
    <name>A0A914I3H6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I3H6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7163.t2">
        <property type="protein sequence ID" value="Gr19_v10_g7163.t2"/>
        <property type="gene ID" value="Gr19_v10_g7163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF133">
        <property type="entry name" value="ETS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3Y3</accession>
    <name>A0A914I3Y3_GLORO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
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            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <begin position="1"/>
            <end position="23"/>
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            <begin position="73"/>
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            <end position="137"/>
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            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6593.t1"/>
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    <sequence length="152" mass="17596" checksum="C6CDEB4DBEF1E3B3" modified="2023-02-22" version="1">MEYFWVLIFVSFFATNSLDKAESVQLEELEELPLQSFDELFVEEWWDNDKAEEWHKLTLEQNVHYQIDRKNAQLGQIEPNSTDQLGQIEPNSTDQNPPLIESDHSGQSEPNSTDQNPPLTESDHSDNAENGEQITSNEKAKRKIFKKRMGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3Y5</accession>
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        </submittedName>
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        <name type="scientific">Globodera rostochiensis</name>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Ig_sub"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN SIDEKICK"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="1304"/>
            <end position="1328"/>
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            <end position="723"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6661.t1"/>
        </source>
    </evidence>
    <sequence length="2288" mass="247156" checksum="1E13FBE758B47737" modified="2023-02-22" version="1">MATTNDNTNTLFFHRFNSLSLHSHHVKNSTNPRQPVPKEGAHAKQILAGTFQIKHHTKDALFFTMTSRFSHELLLIFAIYGASYSCFADDPLIINHKHRRRSSDIEHDPRLLNFRFVHEPSNAIASSSDGSALLDCKFAMASPPPTAPVPIEDADEDNDDNTLISNESSDEELGGLLTRVEWRKEGSPIHPLGRIKLISNGSLWIESVLPVDEGQYQCAVHVITQQQQHTGAADQHGKESHWIFLSRRAALSLPSLHRFEQQPTDQHARAGQMAAFRCLLNSKPPAQIEWHHDNRLLKNGEGGYLVLPVSQTLEISHVRPEHAGVYKCVARNGDRSRTSQLGTLTVLDGEESPQSMHWVLEPRNQLVTVGDSVLLECLANNGGARQSTKIQWLHNSEPLASLAIDGGKALNNNDDGAAAVADVAPSSSSSSLSTSSIFEMVGRRRTHLLIRNNAALRTQDVGATVAVRVSPTITIRPVDVLTQETNDVEFECVAEGVPTPRITWNKNGEVIIPSEYFVIASNKLRIFGLVRDDQGVYQCIADNEVGTEQAAAQLLVDQADILSSYYSLLNRSTHQPIPDDGLNPNPPFQTEHQQHHGVMWRRKNLTSHLPLISPSSDDSVRALVVPKTPAQALSLRATDTGAQSVQLRWDAPLNSQKFGPITHYIVAYREEGSTRERTLNSTDTQQMLDNLRPQTSYSIRVIAVNLVGPGTPSDALLITTKKQESLPGKVRSLRAEVLSSESIQVQWDEPTPIDASSNLDIRYKLFYVKVAKNVTGQENEEDNEDDDDDEEDGEDAFSSETQVLMVKTSYTLHGVAKNAPYSIRVEAENVHGAGPSSEPIVIRTWPDTPSAPPRDVHADSLPQPGHAIRVRWRPPPHAQWNSDALIGHKLRYRMKGGRPPGGGGKATASTVLVEEEEGEDDDDGMEGWWTHTLDGLEPGSAYLIRVAAVNQNGTGPWTDWTPVDTPEEQKEESQISGAPSELRVLASHDSVQVSWLPPRDDNVLIRGYLIGWGINIPDVEKATVEPEVRHFTIRGLKPNREYVISLRAFNRIGHGFPIYETVKTSSYGAHSSSVSSSSIADPKPTFGGFGHQQDNGANSLPPAPVGVVAEAISSSQMRLTWIDPNENAFNQLYTIKYGMSNTDEAQYKLLNSTETEHTFDGLRPDTLFEFAVRLAQSPHHWSLSALNRTFPAPPSSPPRDLTVIGPQSGRPHADNDPSMVTLTWQPPKYANGEIQEYIVLYSDRPNLPDRDWVMDSVKGPQCEGLRSVHAGGQLHHGDHISRASAVCSAAILLGQFFVGMRSNLAFVLIGVVVVVVLLLVVALLAACFQRSKNDHNNVRASATMSNRSQRRHKKQRARSHHQQSYIPGRKMSVSTPSAVAELDDDLWMIHQQPQQHNAGGGGGRFATLINASAIEDFESAATVDDGTGILLIDGQQRAFIAPAGTAAGLNLHPAAMECLTPAHYQQAACHAATTQRQETEHGQLESGVVEVVAFGGSSGPSTSLPHGMLESFHSMTTTAEQSPKSGGGGSTGTKQRRNQHRNSLPPHICPSSSAKISPIVAQKCQQLHLLHHHHHHHQHDHLQNVAARGGTANFGRKSNSPAAADIRPDHQRVATVRMHCGSGGRISKSSLNALDLSISPCLGFYHECYHHSASYSPPAHSSTPKIADHQQNNAAETETELLNKNNSAVPRQFQVGISLPSMALQVKQAKRTATANYEPTTRRHMAPVKSVNFASKLVIVSASDDDECETETAATTAQCRRRRNGNINEDKIAFIDDICISNVDGTGDEHAADAGGNGRVDAGGETVCDDKDEANWMITKMKATTPAQNHSGTNKQNDDYGGGRTVPSLLSASSSAGFASKCVHRKLVGLLCAGWPGLDLLCLFLVVVTTAAASVFSVLFTVNSVGTLPRGHPNHHQQHLHNSSASLEMKSAPQPLHLHQQQQQNHYVQQQQQHQQLGSTPLTPRNPHVVYTRVNRQPIAKVDFSMNGAAAAAAAATTTVPPHDSPHYQQRHQFVGAAVSSAAGGTPPLPPPPPPSSSSLTGACASRTATTTTTASTIIISSHAQHNRNSSEAGYQTVGGGRGNCGTMRSFVDVGTTEDDDNGSCEALPVPPTGEQHQQQQQQQRMAHIVRPIVYAGGGGGGGGGAGGIAGGASPSPSTLRSAVAQKTTPTTAHKFTYNNNGAKVPVGRATAQPRVNLATAAVAAAAAAAAANLPSDVTALYGYSASPSQYASVRAAAANAVNTGGGGGGTKNSMEHGGGGEQLYINNNNSSIKTIDSTEDLEEIDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4B2</accession>
    <name>A0A914I4B2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4B2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g718.t2">
        <property type="protein sequence ID" value="Gr19_v10_g718.t2"/>
        <property type="gene ID" value="Gr19_v10_g718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23128">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS E (EPSILON)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23128:SF132">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS E (EPSILON)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g718.t2"/>
        </source>
    </evidence>
    <sequence length="343" mass="38836" checksum="9B6F9ECF86F360F0" modified="2023-02-22" version="1">MNTNGTTTTPSPAEDWRDICIKLVIWTNLAAFVAQLSLSALNIVLLARTSVLHPNLKMILLSQSASFCIFAIGHIWQMCIMLALGIEHWTDGIVIKILLVFGVVYSNFIGHVMLVERLIATLMSKRYENWKKPHFSLIWFIPIFSFSLFNALQSAPNETSSPVGGNVGIGIMVAAYISIVLSVAEIFACFYIDAQSRKRYAIWAKNGTHSLSERYQLAQNIRTFRQLAPTFVLHLANLIVALPTTLLLYYKLILDTKLYMVVWLTYHLALTVNNGLIEFTLIWRHPILRNETLNFLTALRLFKGNNQICTAQNANIGVQIGTKNGGEMIEMEKHFQMLQKEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4C7</accession>
    <name>A0A914I4C7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4C7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6694.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6694.t1"/>
        <property type="gene ID" value="Gr19_v10_g6694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6694.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21748" checksum="A23EBB3458A8315E" modified="2023-02-22" version="1">MSEESRPTLHLQPRQVLVNSYRDVRPVLRLTLRQMDHPFIKKLEKSTGIDREKLFYILSAFITFYLLFGPGNALLCTLIGIVYPAYQSVLAVRSRTKRDDTQWLTYWCSFALFSVCDFFVAHYVGVLPLYMLLKTICLLYMALPQTCGAHNVYVSYVDPLVDWAAIRIKDATSSSSGMARSSGTARSSGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4D5</accession>
    <name>A0A914I4D5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4D5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6783.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6783.t1"/>
        <property type="gene ID" value="Gr19_v10_g6783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6783.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14675" checksum="3FD6822A684C6D03" modified="2023-02-22" version="1">MQKCPNLCAVAGRCFDGQRRRLSPQNGAHSDGPSCFDVVQARTFEWLLLLLLLAFLVACLIKDFRTRLKAEVRICHSNKEVLHEPGTEKSMLNFRDRQPNPEFKLLLILEVSLLNFDYTRKHQFLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4E0</accession>
    <name>A0A914I4E0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside phosphorylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4E0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7203.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7203.t1"/>
        <property type="gene ID" value="Gr19_v10_g7203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01719">
        <property type="entry name" value="euk_UDPppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610059-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7203.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32836" checksum="5B801CE7E762795D" modified="2023-02-22" version="1">MPASSINDFHPIASAQPDDYLPHLGLSTLNTDFQAQFNDVKFVCTGGSSGRMSEYAKLFSALANVPSSGNLCNRTDRFVMYKTGPVLWVNHGIGMPSLSILLCELFKLLRLACCTDVQFIRVGTCGGVDVKPGTVIISEGVVNAALEKNKFVQWIQGKQVKRDALLDAQMGNDLFSIAVGLNLPAERGLTLSTDDFYEGQMRLDGAFCDYGNEEKLAFLGHLIQIGVKNIEMESTCFAAMIHRAKYSAAICCVVLVNRMEMDTLMLREFHAEFEKRPFEIVSRYILNKISSSNSDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5B9</accession>
    <name>A0A914I5B9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5B9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7031.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7031.t1"/>
        <property type="gene ID" value="Gr19_v10_g7031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7031.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31006" checksum="CBFC74B39E429C7E" modified="2023-02-22" version="1">MRDFYYYKLFQAIATYVLLWQILSFDKLCGKFASPPCFVKSLAPAGECKHFGIIRTNTTADELNSANMKKWSQLINNEQAISDDEQNFMGEMVAKFPTGRQCFPVKISMVSAMKNAFYCNRTDHLEKLADAFAQMLYYVLLFLFTLVFHVMAQDSEKEYDFCGYFCAIYGFVIWCLTTAIAAMLYLNWTTHWECTNFRPDNLSMLLFIVVLSAVLMCSSLLEIFCNRSLLHKCSATHTKSVITLRTGNEKIDVAQFKQNDQFIVRITKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5D6</accession>
    <name>A0A914I5D6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I5D6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11042.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11042.t1"/>
        <property type="gene ID" value="Gr19_v10_g11042"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6775.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6775.t1"/>
        <property type="gene ID" value="Gr19_v10_g6775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11042.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6775.t1"/>
        </source>
    </evidence>
    <sequence length="462" mass="51844" checksum="4E7D0B93C93D8CD7" modified="2023-02-22" version="1">MKKLFRKCNDIKNGQRQTQEWAKVALKGCSKQTCIAFVLDAECFNQLLQQYDDELFNARCLNAETEEQRVVLADQLAQLHASIDRDEQEKEALVSEKEVLEAEKEVLVSEKEALVSEKETLVSEKEVLEAEKEVLVSEKEALVSEKEALVSEKETLVSEKETLVSEKEALVSEKEALVSEKEALEAEKDALISQKDELEADNVELHGQLHEQRALDDRLQEKVQALADDVQCLQEQLVELNVRCAEFQEEVEVKDGEINKLHTSMEQKEIDFKQLCAVKNQQHDALDVSKSEAKLGAVVPQDVRGHAFLASKRRSNEWDDDDGEITFIGISKRSKSSETTPVTVAAAPPLNSSKLTSVTATAAPPLNSSNSTAIDQPLMPLPRCTDMLEQFWHVVKQNERAMLCGWTNASALVDQFMLCNTSCVEQPQDKQAQLRVHLLQFAVSIFGHVQSEKSLPPCPYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I5F8</accession>
    <name>A0A914I5F8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g769.t1">
        <property type="protein sequence ID" value="Gr19_v10_g769.t1"/>
        <property type="gene ID" value="Gr19_v10_g769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05495">
        <property type="entry name" value="Bromo_cbp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15557">
        <property type="entry name" value="PHD_CBP_p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15802">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031162">
        <property type="entry name" value="CBP_P300_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003101">
        <property type="entry name" value="KIX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056484">
        <property type="entry name" value="PHD_P300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010303">
        <property type="entry name" value="RING_CBP-p300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038547">
        <property type="entry name" value="RING_CBP-p300_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02172">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23570">
        <property type="entry name" value="PHD_P300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06001">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47040">
        <property type="entry name" value="Kix domain of CBP (creb binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51727">
        <property type="entry name" value="CBP_P300_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50952">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="21">
        <location>
            <begin position="548"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="KIX" evidence="22">
        <location>
            <begin position="782"/>
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    <sequence length="2301" mass="251319" checksum="65E4D7A64CD878AE" modified="2023-02-22" version="1">MSSGEEKLAEQDEQQQHSVGGATKRKLAAQASFDDDLDLDGFSELDTAAEAAEQSAGSVPNNGGAAFQNGTTVSSSAATTTTAAPQPQQQQQSVLQELLLTQSTASAMHNNSPRPSSAYTAGSSGGTFPTKSPMAPSHQMAHHGTPMAPQQNMSPMGMMGPGAVASVGPARATAAQLSQHQQIRQQQMAAAAAAAAAGHHGGGAVGFDPSTMVSQGGGAGTYLSQQQQQFGMYHQHARPAPSMYGTSTVNTASSSARLLPGAQQQQQTPSNGLRQPVGSFSGGGGGGPSTNSSKGIKQQAQHHPGMMMMGGGNAPTPPASRPMMIGQPGPMGAAQPPPSFDSSVAHSYHHQQQQQQPGQSSSAMLPHAMNGPLSSQRDSNNGFMMAGPGAHHPMQSTYMGTQQQRMPSSTFGQPPSGAQQQQAQQSMLHGSMDASAHHHHQQQQQQQQSGGGGSAMLVNGQQQPMVAATAQQPSQRQSMAVPTSSNQIGGVGAGGMLVAQSPLGMLNAQQQSMNSNGPQQLRGVVQQQNQQQQQQMLASGGGGGQPQDPEKRKLIQQQLVLLLHAHKCQQRERSELPQNRAPCTLPYCTVMKGVLEHMVGCTAGRQCQYAHCASSRQIISHWKNCSKDDCPVCNPVKRYTNGTAADRRQGDIMLSAASFPTVLPQQTLQGAIGQQQPSSSASVGGPSSVGMCGGGASASSSIGGGPLSSFGSPPSASSAVNNLLDGYTPNTNPFLSINPPNRVGQSPHQMGVGNGQQLQMGVGGPVGFGSAGEGMPPPEPPNQPRDWHASITPDLRNHLVGKLVKAIFPYPDPAAVRDQRIRDLLCYARKVEKDMFEAANDKEAYYHMLAEKIYKIQKELQEKKNRRLGEAQLLAHQQQQLRSSGDQQQLAMLEDSASVHSLNSMSMPMSASAVHQQQFGTPQPFGSVSREVKQEPREQQQPPMLNFVDAAAAGVPPSKRIKMEESHPQQAMGGGGTCSTLRSTSGSDAGTESVGGIKQENISGGTTTAGPSAPLSSSSAGGLFPPTTAECRRSTTPKDVKPSTSSASSVVQQEPIVRDPKVFDANELRQHLLPVWHRLMQSEPAVIPFRFPVDPKELNIPDYFDIVKHPMDLQTIRANLDQGKYKNPLEFCDHMWLMFENAWLYNRKNTKIHKWCTQLSELFVEEINPVMRRMGYCCGQKLSFTPLVQFCFGITKNNAACVIARDQPYLMYESSSTGFGVTVAERYIYCVKCFEALPDEGINLNENTPEPPNWIPKTMFQKMKNDQIDMEPFEQCQSCERKWHRICALHSNKIHPGGFVCDQCRAEKGRSRPDNRFTAKKLPHYNLSRHIEDRVNNFLRRKLTESDPEVEVIIRVLCSADKEVEVKPAMLKKYASEGYPDRFPYRSKTVFAFELVKDPDTGASHEVCFFGLYVQEYGTNCQPPNQRRVYIAYLDSVHFFQPRTLRTAVYYEIMLGYLDYAKSLGYTMAHIWACPPSEGDDYIFHCHPQEQKIPKPKRLQDWYKTMLNNGQAKDDGLDTPMKLPYFEGDYWPRIIDECIVSAEKEEEQDRRMKLQQDENSTTAGGSVASAVAAATLSDDDTFQTDDGFPVAKQKQQQNQQQKNNKKKAGFTTGNPVVDKLFQQLDKHRDVFFTIRLFSAQEEQRVLAEKPRIEDPDPLVVCELMDTRDNFLAKSREEHWEFSQMRRAKWSTLNFCYTLHTQEQEGVKGVNYTCNVCEKPACFHCNQCEDYDLCDQCRAKSNHPHEMEKLILGDDQKLADSASSAASRNDSVKKCISSLVHACTCRDANCRRGTCHKMKRVIQHTKTCKRRQSIGSNCAVCKQLIALCCYHAKHCTQTKCQVPFCLQIRAKLQEQKRSQNRQAERMMQRRMMKLQSVGAMNGGGGGSSSQMAPSVPTTSSSSVSSVSMQQQQQSPWAQPQSPRQQQQIGGQFGAPQMQMSGMMMSPNAMPQQQRLNGPMGGPVTAAAAAAYHQMQNPMSGAHQQMINSPPMSQYQTMGGPSSVIGPGGVGHHQQLQQQHPSAAAAGGYSMVGAVNHHLQQSGGQQLMGSVGLHRVPSSGALQQHQQHLQQQMMSPNSQQHITPPPYVRSAGAAQQSPLHHHQQQQQPPFSGATPQGMNPLQPQVRGASQQPQQGAQPKQQQQQQRIFQQQQMRVMGHQVMNNSDVQLLMNRFKEASQRGQDDVEAFFVELRKTPHLLNAFLKLTKKQGVSLSSELLVHQQQGGSAVQQHFIQPAPTSIPPSSSYYQQQPSPAMVQQQQQNGGAGIQQFGTFQQQLAPHGTAGGQWMPPGQAQQQSAPQRNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
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        <dbReference type="NCBI Taxonomy" id="31243"/>
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            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
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            <taxon>Globodera</taxon>
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</entry>
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            <begin position="56"/>
            <end position="77"/>
        </location>
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            <begin position="1"/>
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            <begin position="13"/>
            <end position="37"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Proteomes" id="UP000887572"/>
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    </evidence>
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            <dbReference type="WBParaSite" id="Gr19_v10_g8449.t1"/>
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    <sequence length="100" mass="10513" checksum="AF0DB6998611497F" modified="2023-02-22" version="1">MDHHQQQQRHSSADPSSLPPLLSASSSSMPMPKPNNSIQLFPTKKASSSSSCCCKMLLIMFGFILLLLLLLAAAFLLSFGAEHIRGAVVGGGGGGMDGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I8K0</accession>
    <name>A0A914I8K0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WASH complex subunit 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I8K0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7636.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7636.t1"/>
        <property type="gene ID" value="Gr19_v10_g7636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028191">
        <property type="entry name" value="WASH-4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028283">
        <property type="entry name" value="WASH-7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028282">
        <property type="entry name" value="WASH-7_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027307">
        <property type="entry name" value="WASH7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14745">
        <property type="entry name" value="WASH-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14746">
        <property type="entry name" value="WASH-7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14744">
        <property type="entry name" value="WASH-7_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH complex subunit 4 N-terminal" evidence="3">
        <location>
            <begin position="56"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 central" evidence="2">
        <location>
            <begin position="625"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 central" evidence="2">
        <location>
            <begin position="751"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 C-terminal" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7636.t1"/>
        </source>
    </evidence>
    <sequence length="1232" mass="138243" checksum="190EB19E8336B4D0" modified="2023-02-22" version="1">MDAARQSRARAFVAAQFVTDVLAPLRAVDNGTAGHCSRNYCKIRSGCTLDSDFPSVHTSDAHSMVDACTSIFADLLNSADRCISLARSSLFDSLLLYGESGHHLPDCDEGASVIELISDFLPHLHTLDTFVRQCERLAACIFCQLNALLALSSSNGGLSAAQQQQQLISLTLVDGIRDLAMDRVWRCLGELLSVLIVFDEMIGHHPFLRTHWSQFVRSLRLAQHNPAQFALHGQSGRLQQLNEEIARLDAELMGGNIFGNICQRLARALFDSFPQQQRASSVPSAGERAFIDRFRRAIMDFLARWDRLSAAEDAIPDKQSLLALLALAQLFHALLAANNKNGDAKWKMIDRKMLRALYATHKRVVAFHLVGDILFTPAEHIAKTYGPIDADVIERKAKTSATQARAVLLEHQIAQMDREAQMLKLCVTEWCQKMDEFGCCPPTNGEPPEEIVDRKCNLLFDGARIVDKIGRLLKCILNGHLEKNRPLTKQNVRLLFKLVQQFKRISTTFCFQWAAVLEWTQFGCAKTASALLLLFDGQIGALVSTASGRGAKNAHAVAAFRNAQFSLAQTITKNGIVRCGVAVEMANYSKLLRLPDVQRVDDQLIRLDLLSNVGALLHRVTDLSFLYWHRQFLCETFCGYLISDTAAGECDLHFFEALSDSTHQLLQNAVHSDHQALLHSFGIEMFAIFKEKFLDKLCTKIENDLRFSYHSQQSASLGLMGQLLFGGTSDGIGGLFLGHPDDPTSKSACSPSATAAQHLFRLLHLPPFQMGDKLINVKAFVTCHLESTFYNLSVLALHDCDSYRRMALLAHQRYQVRLFDTGLPNMSVDQGLDLLMVMTDVDTFVANYCYDLNEQFFIERSGHGKSQLSILRAQQVVNSVKTHGLGILNTLVNSAYKFLRVQLQRLSLCLFDERIKTLLMQEIRFYRDAMDELDQLYPMSRAERLANALRRYDGASLGTDGGADCLNKLRVLITRMGNMLGLLRLIRTGIVEFCSPVIFHESLDTVGAEKGHKTTDQQHNPTAAHVAEDARRLRDRALQNALCSLTDSRDCVELLTSVFAREFRCNGSKNYGHLRHFFVAVPALTLCHVEHTTGCRARLQTSARRETAMTTEHPEERQQQTVFVEDGFSMGVAYVLTLLNQRFFFDFLNWCDSVQNRFFRAELAKNSAELREAQKRKDESLARVLAVKTTQLDERRAEHRLLACTLNSALTLFQANEMLGEEQGEETFLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9W6</accession>
    <name>A0A914I9W6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9W6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8241.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8241.t1"/>
        <property type="gene ID" value="Gr19_v10_g8241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000247">
        <property type="entry name" value="ADP-ribosylation factor-like GTPase 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8241.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21026" checksum="B273D046CF16278A" modified="2023-02-22" version="1">MISMINKLLDWIRSLFWKEEMELTLVGLQSSGKTTFVNVIASGQFTEDMIPTVGFNMRKITKGNVTIKLWDIGGQPRFRSMWERYCRGVNAIVFMVDAADKAKLEPAKSELMQLLSKPQLEAIPVLVLGNKKDLPDALDEGQLIDAMNLESIQNREICCYSISCKEKSNIDITLQWLIQHSKTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IA80</accession>
    <name>A0A914IA80_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IA80"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8723.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8723.t1"/>
        <property type="gene ID" value="Gr19_v10_g8723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8723.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36306" checksum="6AF1A27384BBC6F1" modified="2023-02-22" version="1">MRKSSVSAQLTRTARRFSTVIAPQLTKLDAVPVLQKHQRLLIRIADISKLQEAIKQYVLHNGRLFDPVEFEIRADDDAGAGPPLLTAQFYAEEIVLFDGTKRLLSISLSDPSEQDLLQRFNSSASVMKSLDEGSVLAKVRHPISGIKMFELIQSSQRLPERWHITGAMDELNKCEIQANSNVWRQVLSACGFVFAAEWWTVQSEGIRIAQICPQKAVCEENSLRLEWSDLANNELRLLTLCFGLVQTVREAFPSLMHIVKEHRQRKMNIHHAPQGSLLTPSPTSNLFCFFGLSSRIDGFAFARPELNESEVPHPLEYLNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IAW6</accession>
    <name>A0A914IAW6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IAW6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8498.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8498.t1"/>
        <property type="gene ID" value="Gr19_v10_g8498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8498.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27511" checksum="C97767E1195FE365" modified="2023-02-22" version="1">MAWHFRWHGRQQKSEKNVAPSAYGGGQWTTTVQRRQQQQIKTNSAAASSPIQNIFLAFCSSVANSLQDASNKIANLVKRRTPSPSSATHFPPESPQPSYVSVLSPNELSPRQYRKFPSSPPNGADGGQLVPSRLRSILKKPRPSPLRGAANTAASSSTAPGNVPTVSYRIPVLRVDEAPRQRAPPAVPQQWEWNTRFRDAPCERVVEDRVEREECLRRGRLVAVERLTRTVRASADIGRRRQPATYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB02</accession>
    <name>A0A914IB02_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB02"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8925.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8925.t1"/>
        <property type="gene ID" value="Gr19_v10_g8925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037401826" evidence="2">
        <location>
            <begin position="24"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8925.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="26427" checksum="0313F10E9114CB94" modified="2023-02-22" version="1">MRTIFVVAIICFVLATILESANSKPPAGDKKDKKGVASSPTKSKLPPKSPAKAAPTSPVPKSPSKKDSKAPTSPGKAVPKSPSKKDSKTPPSPKNDNANKTKPETVGQTPSPAKKVGSAAKSPVRANRTLNFDESKPSTAGVTNANNAVKSPEKQEQPSLPMSNPSVDAFGPFEPAIVAYSEAFDEEDTSGSDFDLDFTEGEHDDDDYSDYREYFEDFDAFKEDDPLALGNDYLGTGVEHVPESVMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IB65</accession>
    <name>A0A914IB65_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Intersectin-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IB65"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8335.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8335.t1"/>
        <property type="gene ID" value="Gr19_v10_g8335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097708">
        <property type="term" value="C:intracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150007">
        <property type="term" value="P:clathrin-dependent synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000055">
        <property type="entry name" value="Intersectin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="EH" evidence="7">
        <location>
            <begin position="47"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="7">
        <location>
            <begin position="200"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="670"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="868"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="968"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8335.t1"/>
        </source>
    </evidence>
    <sequence length="1168" mass="130975" checksum="43C77EABF2D97A22" modified="2023-02-22" version="1">MMFLPNSSGSAAQTPLSSNNFAYLNNANQQNVKPQHSPNPWLITSQEQQQNEGQFVVLRPVNGLIGGEQARPFFLKSGLPPIVLAQIWQLADVNKDGKLDRFEFSIAMKLVLNCLAGISLPSVLPDSMLRVSGGPSTALPSSLSQPRPMSTYGSMPAMASSYQRSYGSFSAAQTPVSTSSSSPFLMGIKELGDWSLPQLLKLRFSQQFNQLDKSRIGLLTGQQSRGVLGESQLPTNILAQIWNMSDVNKDGCLSIEEFCVAMFLIEMVKAGYALPPKLPNELHSFCNRSKTVSPSTMATEDDPSAPPPQKPGHGQFRTFEDKRKDNLDKGQAELERRRRILREEEERRRADIERREREETERRERERQELERRREAEMEEERLRDMARERERAAEEQRLNGEREEARKRLEQDRIRELEKIRVRDLENQLLAETEKSTQIQQRQHTMAFQLQALEERSQQLNGDITDARDNIMAITQEIERMREQRDIKLVKISELERRNKELAVQSERFCHENLQHQSEVQRQLSRANEISAIRSEIAQLDDQIKQGENEIQTFVTRSQNQEKIVTEKRPLWEESCKNIQPVRKLFGELLERYNNSRSEAGAFYEGLRMRERHGQIMPPHLMTISIPISPLLLVKKQVTLTGESAFSNQNLSSAANEAIQQHGQVIGQLKTVKYKAIFEFNARSSDELSIQPGDLILVFEGHQSEPGWLAGQIRDKVGWFPASFAEPLANAVAPLIKGGSLAGSPSSEPLASIQEECEPPAGGVGPVQPSEQKREYAFGTDFASAFTKSVSFTDSATIGKAMEMAQPKESSVSASASVSAALYDLPPIGVENVPKPINGIQTSSCTVKTSSVPITTSASVESSADDVVLTVGVALYQWKARNDQEMSFGRGDSIEVLEQGEMRWRGRLQNNKQVTGWFPKSYIKVGLLTPSGDYCTVTKEGKERLQHATNFGQTDQTATKTNERPNENGEWFIALYQFDAVETTDLPLKPGNRIWVTDQRDQWWRGTCDGKSGIFPANYVQREGGNSSTAPLVQRDSTVDRQMVGRAIATFTATASNQISFAAGDTVKIHQTTPGGWWEGDVEKAGVRQTGWFPGNYVQAFHPSGEVVFAVAAFDYTAQHDDELTFKLGDIVEVVDRSDSLWWKGRKKGQPEQKALLFPANFVQINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBD6</accession>
    <name>A0A914IBD6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBD6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9024.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9024.t1"/>
        <property type="gene ID" value="Gr19_v10_g9024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037847714" evidence="2">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9024.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="10932" checksum="A790466F693EAD1E" modified="2023-02-22" version="1">MPAKLFPMPTLFLFLGLLCLDLVSSTKMIETEGNASNSVANSANNGPAQALPSTPKKLIAPGLICPPAPKKLRLTSADTSGPPATRERIISLEEIAKNGQVFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBG2</accession>
    <name>A0A914IBG2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBG2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9294.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9294.t1"/>
        <property type="gene ID" value="Gr19_v10_g9294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9294.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12468" checksum="5261DCC1AFCC5D47" modified="2023-02-22" version="1">MKIVTSTMTNLHEILPECKLLIDNLMNQGSGEAVLRLLREWCQAFGKGICLTIFLNELRIQKFIGGAYRHRQIPSSPKLKISEDPTFAPQTFAVQTFAATAKIRHLRLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBG9</accession>
    <name>A0A914IBG9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBG9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9056.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9056.t1"/>
        <property type="gene ID" value="Gr19_v10_g9056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9056.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20267" checksum="9CD5ED6CCE16B43E" modified="2023-02-22" version="1">MRQNLPRGHSGSDSTREHAIQTPIAKLFAKNCMLKNEIKKFKGILKKLYEEREQRGLSKVKSFDNSLKKEQFDQIKNNCERRRRYRVTKLKNENKISLSKFLLTAIVSFLGLYGERMVEEEKCQYIDQLVAESGMFLPGPKNPAEITFERFEIHLKNEQIEEAVDCECQFFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBI2</accession>
    <name>A0A914IBI2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBI2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9310.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9310.t1"/>
        <property type="gene ID" value="Gr19_v10_g9310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037564005" evidence="1">
        <location>
            <begin position="21"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9310.t1"/>
        </source>
    </evidence>
    <sequence length="720" mass="81491" checksum="5093497D4AB06ECB" modified="2023-02-22" version="1">MFNFFSILLLLTAVLQIVEAIQIGVKPSNLRYKAEISCLQRKRSITIGTAKHESAFFGARVATGCVDIRTDLSRCDDHHNSTVKVLITNLDRPSDSMEFEIPKAELSARRSAVVLAFNIEPRAYKQFYFQHSSTNFGVSQRPLVDYELQIECKYRHADGALTHYLIGSGIQFNGQNGINMPIYEIEMLAFCEEDRIGLAIHNAEHETTTFINVTREFLLQNDAFNINMSNETVQPIHNDALLLLAAALHIVEAIKIWVKPSNLRYKAEISCLRHNLRITIGQATHALSFGEYGTAGYVNIRTVLSRCDDSTVKSWGWRKGTVLNGEGTEPFGERGVSRKPGPVKVRITNLDDPSDSSIFEIPKAGLSARRSAVVLAFNIEPRTYKQFYFQQSPTNFGVSQRPLVDYELQIECKYRHADGTKQYYLIGSGIQFNGQNGINMPIYEIERLAFCEEGKIGLAIQKNAENETTYINVTKQFFLQNGAFKINMSNKTVQPIHNDALKMVEEIEPKMKTIEYGTAGYVDIDTDLSRCDDHHNSTVKVLITNLDRPSDSAQFEIPKAELSARRSAVVLGFNILPSAPKQFYFNNRPQILGKCDQRNSTVKVLITNLDRPSDSMEFEIPKAELSARKSAVVLAFNIEPRAYKIFYFQQSSSIFRYFQQSPLEKLAFCSQGRIGLNIYNAEHETTHINLTKEFFLENDAFKINMRNKTVQPILQNGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBW2</accession>
    <name>A0A914IBW2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBW2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9176.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9176.t1"/>
        <property type="gene ID" value="Gr19_v10_g9176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022:SF1">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037687105" evidence="1">
        <location>
            <begin position="26"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9176.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40514" checksum="95513C7AFB41988F" modified="2023-02-22" version="1">MKSFSIQNFFILHIFLLFLLPLAKCNPNALTGELRLRLDKFSEFVKQPVGTERKGDEVKVRGLSWHLKASINELITAKYIKIWLICTNDCKIDPNWNCYASSVIKIIVGQKEVMTKRMGGNFNERDFSFYSQRIQIENLLKECQSANEDSVEFVAKVVPDAPCGNSLPRTDILTVKSSGDENASVLINKNYLAAHSNFFNDLFNENGHADRGMSEGWNENVENVLRLANQFLVKEVEGKCKRFLTSEQCKIRTMKKLLIADKYGLDALGEYILYTTKYKNPILMEMSRLIKGLYCAIVTCLRQLSLTMKAQKRGKEFEMKEVWHNVRLLGTGISQICHLPSIPFKLLNFFPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICA3</accession>
    <name>A0A914ICA3_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="5 14">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="5 14"/>
    <dbReference type="AlphaFoldDB" id="A0A914ICA3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8610.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8610.t1"/>
        <property type="gene ID" value="Gr19_v10_g8610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="640"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="676"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8610.t1"/>
        </source>
    </evidence>
    <sequence length="746" mass="84035" checksum="64C492E0CA469839" modified="2023-02-22" version="1">MATTGSRKASVLFSSVFRRRTLIGLGFGTVVAAGVYYLDVSNEKRFRRGMDVYFLPHAQAATVDAKSMLNKRPSGPLPTRADLLKGLRGEEFDILVIGGGATGAGVALDAQTRGLKTALVELDDFSSGTSSRSTKLIHGGVRYLQAAIMRFDREQYRMVKEALFERANLLEIAPHLSYPLPIMLPIYKLWQVPYYWVGIKMYDWVSGKRILKNSYYIDKEKALERFPMLKKESLKGALIYYDGQHNDARMNLAIVLSAIRNGAKCCNHVAVEHLLKDENGKLCGAQVKNMVTGEMFPVRAKCVVNATGPFTDSIRMMADPDTEPICRPSAGVHIVLPGYYSPANTGLLDPSTTDGRVIFFLPWQKMTVAGTTDFQCDVTFSPKPRNSDIEFILSEIRGYLNKDISVRRGDVMSAWSGLRPLVNDPNKKDTKSLARNHIIEVSKSNLITIAGGKWTTYRHMAEETVDACVKACNLTPKNECMTPGLMLEGAHDWYPLLYINLVQDYGIEVDVAQHLANTYGDRAFVVARMCKMTGKRWPIVGRRLHEEFPYLDAEVSYAIKEYACTAVDVIARRLRLSFLNTYAAHEVLDQVVLIMARELAWSRQETESQLLVARNFINNEMGQEARMQSVSDVPLNLTKEEMQLAKERFNQLDKDKKGHITVNDIRRHFREHGNKIDERLLHDLLNEVDLNKNGELELAEFFQLYSGLKSGQITQNRLVRYLDELGAGKDEAAKAALDVARDPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID99</accession>
    <name>A0A914ID99_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="13">PARP</shortName>
            <ecNumber evidence="13">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914ID99"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8816.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8816.t1"/>
        <property type="gene ID" value="Gr19_v10_g8816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08001">
        <property type="entry name" value="WGR_PARP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049296">
        <property type="entry name" value="PARP1-like_PADR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21728">
        <property type="entry name" value="PADR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01335">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52007">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="2 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="15">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="18">
        <location>
            <begin position="342"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="17">
        <location>
            <begin position="469"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="16">
        <location>
            <begin position="558"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="161"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8816.t1"/>
        </source>
    </evidence>
    <sequence length="795" mass="89814" checksum="6CAB6D0297BEC1A7" modified="2023-02-22" version="1">MDMNETETPKEPPYGAEYAKSGRSSCKGCKQLISQSELRMAVRFASKFFDGMQENWHHFECFWKKARKNELSEAAIRGMEWLKWEDQERIRTRITEFKASDDSGYTPKSATLAIEHAKSGTSNKASFYHVECYHSFGIFQKSAEDLVGYTDLTEDEQKRINGFFPKATQTPAEESGGSKRKKEESTSGTLEGTPIAKRMKTEGVDDDAKLKKQSEALWNTRTALRDNLSNGEMEELLEANGNYKSKKGGVERMLDKLVDCVVFGVPQPCSQCKGALNYNSTLHSYKCSAALTDEVVLEPKPHTNLKSVSRESRKKSGSSSGRQKLVEKHGFVVDPQCDVADTCHVYLDPETKQPWQVNLSVVDISRGKNSYYKLQIVKEDYGSNFYLFRSWGRIGTTIGGTKTNAYGTDREDCIDEFKRLFEEKSLNDWESYIAGEFKKKPGGMDILDVGFTEKKNDINTSTFDVEKSVSNLPRPVKEILSMVFDVNLFTDTLREFEIDLTKMPLGRLSRAQVLKADRMAKFSLYHEESLWTLPIDSTLSSHTPPGEVYHEKEAGDKDAFDLHYEKLNCKMEVLDQNSQEFSLIKKLVDVGHAPTHGIQLEIINVLKIEREVESKRFKKDIGNLHLLWHGSRLSNYIGILSQGLRISPPEAPVTGYMFGKGIYFADMVTKSANYCYVMNGQGLLLLCEVALGDIQEEKNGREIKKPKKGKNSVKGVGGTVPNPDEFENLNGATIPCGKPIKLDAKDLSLLYNEFVVYDEAQIRLKYLISNQNPLYLIYSCNVYFALCVNTLNTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IEF1</accession>
    <name>A0A914IEF1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IEF1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9135.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9135.t1"/>
        <property type="gene ID" value="Gr19_v10_g9135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.50">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016133">
        <property type="entry name" value="Insect_cyst_antifreeze_prot"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51156">
        <property type="entry name" value="Insect cysteine-rich antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9135.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11397" checksum="9A8098A065088E63" modified="2023-02-22" version="1">MLWADQFLWADKLLWADQLLSANGQINCYGLINCYGLINCYGLISCYGLISCYGQINCYGLIKCYGLINSYGLINCYGLINCYGLINSYGLINCYGLRIPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IF28</accession>
    <name>A0A914IF28_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IF28"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g930.t1">
        <property type="protein sequence ID" value="Gr19_v10_g930.t1"/>
        <property type="gene ID" value="Gr19_v10_g930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g930.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14765" checksum="04F0FDBF62270EFD" modified="2023-02-22" version="1">MCDRLTQIQDLVNELANHMCNSVGVLQASAGPCEFGNASEELKQEPNCRLFAQQIARTSKDIEILIDSLPADEQSLSVEEHEKALLELDDERARAAKELEQAVERAESLTDKLGELLSRIARLQMVSRPSAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IFM6</accession>
    <name>A0A914IFM6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IFM6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9799.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9799.t1"/>
        <property type="gene ID" value="Gr19_v10_g9799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="245"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="481"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9799.t1"/>
        </source>
    </evidence>
    <sequence length="773" mass="87072" checksum="0AD6DE73C721AB34" modified="2023-02-22" version="1">MTKNPNSSLGRMEHLLSTGDGADVQFLVGQGDEKELLPAHKLILKTASDVFETMFRFDEGNAKTAAAGTEIKPVEVPDVEVGAFKTMLSFIYADALGGLNGDNAISVLYAAKKYDVPGLVKACVAFPIPALRNVFVAFDQARLHGEEAFIWADEQCRQYGKECSAENRRAMLGAALFKIRFPLISTEDFVENIVPCGVLTDAELLSVYMRHCHPGRALPEQYHLQFSTKRRTVTKSPGDDPYKAIAKIRLRIKGFWYLEFAEDEENSRQLSKPVYIRGLRWKISASSRTNCDHKCLSFYLQCNAEDCDPNWSCAWSATFKIVSQMEEKKDLIRDYCNTFNATNNRAGYALFTSLKKLRDPKNGWYDALNDSVILEVNAFIWADEQCRQYGKECSAENRRAMLGAALFKIRFPLISTEDFVENIVPCGVLTDAELLSVYMRHCHPGRALPEQYHLQFSTKRRTVTKSPGDDPYKAIAKIRLRIKGLWYLEFAEDEENSRQLSKPVYIRGLRWKISASSRTNCDHKCLSFYLQCNAEDCDPNWSCAWSATFIIVSQTEGKKDLIRDYCNTFNATNNRAGYALFTSLKKLRDPKNGWYDALNDSVILEVNVIADKPHGVERACSLDDGDVSAERAEDDGFEKHQQPTTDPRYPKRQIHSLCMVLTRKCFDEELDPICAKEGGTPGECQFCLTGLCNKVVPLTVVRGSQSPPPPFVSPPIVLKASNEKGGDVMSRRARSLDDGDVSVERAEDDGLRCTNNRPKTPQNPTKPNIYIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IGG1</accession>
    <name>A0A914IGG1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914IGG1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9653.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9653.t2"/>
        <property type="gene ID" value="Gr19_v10_g9653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9653.t2"/>
        </source>
    </evidence>
    <sequence length="520" mass="58469" checksum="CE9DDBC6485C36BB" modified="2023-02-22" version="1">MSNSSSDQPPPPLTYFDLFRQNGGHTAAMWLILGEKCALSLVGILFNAILVVATVKAKNLRSICNLLIAIDSAFLALFQLSALIAFLIALFGINFVPVSTCFYLQALPIFSVMMSFCVMFQIGLERLANVLFPIWSMKKNSKRFHVGLLLFFILTNLFLIWLCYSAYYDVNTMVMCTPSDITAKGLFYTIAFNRSVIMHILLIIIYIAIFLILKFKKGNQNFSKSIFRSLLYLVVFEVFGWLPPIYLINIFQKLQLSPVTGTYISAAFTTISSCITASANAPTLYYFSHLYRDAINAILVDVGIKNGGNRQTNASNSVVVVPRDDNLHDIVKSSLFTISMTPPNNCLIQRYPLINQQSVCLTPIVIQHWAIGDRCFFFATATRETRVTKCVETPAAPSTRYFHGDPGGFQSQQRREKRKEKKEEAGTGSDRIGNLGDAAVPKKKRTRAFAHPSLIRVIRQNRAFVMSALIWGLILDVRRQLPLLFAFLPEGIRSFEWAHMASKCLLLLTILIGIIDLLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GPM1</accession>
    <name>A0A914GPM1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GPM1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10259.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10259.t1"/>
        <property type="gene ID" value="Gr19_v10_g10259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037768976" evidence="1">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10259.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15912" checksum="2A803DD428F9D846" modified="2023-02-22" version="1">MFKILCLIVLCIASTIAEDYDKYCKCPANEEPGQKSCNGCEPSCENPKPDVCTTKFCKCSCDCVKGMVRDSQTKKCVSQYKCPPKCPQDEETGSEKCNGCEPSCDKPSPYGCTKMNCSTCQCVKGLVRDPKTNKCVSQYKCPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GR66</accession>
    <name>A0A914GR66_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GR66"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10546.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10546.t1"/>
        <property type="gene ID" value="Gr19_v10_g10546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10546.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16506" checksum="1CA76F6D48B09FAD" modified="2023-02-22" version="1">MEFLEDDGMPPILDGPFSPARNESLAETNNSDGTKVFRLADCLEILESVARDYDCIYPLPKLGRDHHMSGCLLTRSLGSANRMYIFEWEECLELKGHLEMEDGSSKRVLHEFYEKYDGIEGLGRFLRECLFNFFYLLYSAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRH2</accession>
    <name>A0A914GRH2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRH2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10073.t1">
        <property type="protein sequence ID" value="Gr19_v10_g10073.t1"/>
        <property type="gene ID" value="Gr19_v10_g10073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10073.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41307" checksum="916D2BA689BA507B" modified="2023-02-22" version="1">MSDNASDKEQQQQMEEIFICDDVWHGVFAFIDPFELGLKMALISDRLDVLVDVHLKSREWSLGRLDICRAIGGNGAQIFNKRSGERQPIPEGPLPSKVTGFKKLEICHIDQSVIEFLQRIRRLFDASGTNVFIQSNVGYDYLTISRAWEIIRQTIWPLVNDNICCLYLVEYSMFDSSQFGRLRQFSPTVLRNCSNLRSIFSHGLLPAFPAEDNAEASSRQALAKWLLTPCGNGLPKVLDCRYDPAQIEGLKGSFVNALEPVNFIINFCNVGYVDIEPFELKNNWTGERLTFRQINVGKSLLVRCPIGREEDKWAKWEKETIGWFWYRQWNRIDIKWTIGIEWSIGDGMAEANEGPNEPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GRS9</accession>
    <name>A0A914GRS9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GRS9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10797.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10797.t2"/>
        <property type="gene ID" value="Gr19_v10_g10797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10797.t2"/>
        </source>
    </evidence>
    <sequence length="152" mass="17795" checksum="9AB55AB1848F34FD" modified="2023-02-22" version="1">MSPTSLYHYGLLGPRKQIIVFGHREMSQEFEGNKILEFVSGGSKQYSIKLQNVLDGGIWHKTKIRGITFNKKNKLDHEDFKQMILNYKDYNKKKYDYIQDLALLIIFYCLLAAFVIFIVIYCCKQKQIGDSTNTANIKNESIQNKHLFCRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GTJ8</accession>
    <name>A0A914GTJ8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GTJ8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11091.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11091.t1"/>
        <property type="gene ID" value="Gr19_v10_g11091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11091.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7384" checksum="7460F35DF5C7ECE9" modified="2023-02-22" version="1">MSPLLSPSRVMFFTPSWANPACSSTTIVHFCRAANASAPPRRRCKAAQIFQTEAATEFDQLTHTEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GUN7</accession>
    <name>A0A914GUN7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GUN7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1136.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1136.t1"/>
        <property type="gene ID" value="Gr19_v10_g1136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1136.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23698" checksum="3B4200A984178432" modified="2023-02-22" version="1">MASDDIKELKAITLQILKNQTLMIAHLVNQAQAQQPQLKLKQVKAEPREPSSTMAKRKAPEPPAVEPLKDLSNNKNNGGVVTKRRRSSAPNVESATKPTKFCSVCMVIVKEDNLVNHIWEHIQKKVMKEKGTDSTSAYSFVCDVNGCHFRTNKLDLAGEHANKHPDVERNKVVLDNRENSEPLFLATLAQCYDRMTDVEKDEVYRKRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GV20</accession>
    <name>A0A914GV20_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-related modifier 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GV20"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11445.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11445.t1"/>
        <property type="gene ID" value="Gr19_v10_g11445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11445.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9945" checksum="A1BF72CD9C9F416D" modified="2023-02-22" version="1">MTNHRIKLEFAGGLDALFGGKRESEAQFSKVSRAHIFGMGNDRTEMLVQRDSVRPGVLVLVNDTDWEILGGLDAQLKDGDTVTFISTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVT7</accession>
    <name>A0A914GVT7_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetylcholinesterase</fullName>
            <ecNumber evidence="2">3.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVT7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g10867.t2">
        <property type="protein sequence ID" value="Gr19_v10_g10867.t2"/>
        <property type="gene ID" value="Gr19_v10_g10867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="786"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="638"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="899"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="10">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g10867.t2"/>
        </source>
    </evidence>
    <sequence length="1044" mass="118806" checksum="FE2A4AAACE3AA4C0" modified="2023-02-22" version="1">MSKKAPFLSTFVSSLLLLLFIIFVHITENFASLSSTHQSNVPVEIELVNGHLRGIESIFLHKRVRSFLGVPFAEPPVGELRFRPPQPKRSWNGTVEAITLSPACYQGRDTYNDSFWGSEMWNANTPISEDCLYMNIWAPAEAKNLTVMVWFFGGGFYYGSPSLILYDGKALSLEANVIVVNINYRLGPFGYLFLDNEAVPGNMGMLDQQLALHWIRDNIAAFGGDPKMVTIFGESAGASSIVAHLIAPNSQGLFKNGILQSGSLDNKWSMDTPRRAYEKSIELVRLVGCNRTGLADAIRCLRRIPPAEFTEQLWNIPLNFLEFPLVIVSRDANFFSAEDAFIALRKRHYAQDVNLMIGINHDEGTFWNIYNIPKFFDVSHQPKLSLENFNECVQTAFSRLPDIVREAASHVYLGTRRCEYETGFHQNLADQVNQMVGDYFFTCDSIWLADQLDNAPARVYIYYFDQTSSANPWPKWTGVMHGYEIEYVFGVPIYNGTAGYTQRERTLSEKMVQLWSSFATTGIPSLDHRDGMPERLHWPQYHSQNNPRWLELKASHIKPTRTTKKHECRIWRAARDMEYNEYAVEKLTAALTASVVQTRQLLLLNQLIAMLLKALCILLCFVVIFGCLNAAPNKQKQLLNSPPSSLSSAESEQFNHHDKGHHKNRGVVKQNVENKNIKKMENEHIGTSNRQSVMQTNHQTERRAEQQRRPTERSASRPTERSASRPAERQRPTTQRSANRPVESRHPANAERSGASRPIEQKRKTTQRHKNHQAERRHPTEETDNCPICFESLLGPDAGGLKKLQKCTEHSFHQECIDEWLKNIKNDSCPVCRKKVSKEELPAKRFDPDQVQRNENLNVIDELPLEIVLEILQEQEAGGALPLQIPSQIVEAIQREHRNNLPSTSNAPIQREHRNNLPSTSNAVSTRNEEWEPYEHLLNAVSTRNDEWESHDDLINDEWESYEHMLNEQSGQQTHGQNDQTASAVDLAKNIAVTTGRVLARGLTMLGNSLNDWLDGDENFAQQASTSQTADGIMAYHDNIFCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GVX8</accession>
    <name>A0A914GVX8_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Trehalase</fullName>
            <ecNumber evidence="3 8">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A914GVX8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11682.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11682.t1"/>
        <property type="gene ID" value="Gr19_v10_g11682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502652" description="Trehalase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="795"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11682.t1"/>
        </source>
    </evidence>
    <sequence length="1072" mass="123688" checksum="A532C0439F111E7F" modified="2023-02-22" version="1">MPEYAFIFFLLLPFLPLLLPPAATAKTFYLKTQFEKNDGIVEKDELNCSLNGIDLTELGSERNCEQWPDLAPIFCDGKITEVPVYFCRGRRGWHVGVGEWGCRGWHVRVAEWGRLGWHVKVGEWERRGWHVKVGEWERRGWHVRVAEWGRRGWHVKAVNYWGARMLYLRDSKHFVDRPLLNEPKKVVEQFKARFNVTEWKQFVVSDMSPAQVDELGKFVQENFGKADGLLIPHEPEDWKENPQKFDQIKDAELKTWANEMHKMWKKMSKKMASIMDSKGNQQKHSMLYVSNPFVMPGGRFRELRYWDSYWIVRGLLASGMTSSVRNICKNFAELIDRFGFVPAGNRIFYSKRSQPPFLTLMVYDYFGATGDVKFLKEMLPTLEKEFDFWQTKRSVEVIVKGKKKTFYQYKADTNMPRPEAFCQDVDLVKNMSDPKEKAKVWRNIASASESGWDFSSRWIQKDEADTANAWKLTNLMTTRIVPMDLNALMCGNMEMLAHLYLQIGDKAKSRAYHGKYQLFMEDFKSLFYKKEHGIWYDYNMDSGTLNEAYYGSAAMPLFVRCYDTIDLGTAERLFQRLELFDKQHKLVGHPFGVPVSITVNSSQQWDFPNILPPSQHMLIEGLRRSSNKRMEEKATEMAQKWVSANYNLFQNCLRQMWDKMTADTGTPGSGGEYSAQTGFGWTNGAMLDLLVTYGDVLKLKSLPEIDCRLKNLVQEPEQYPNNVSEYRAQRFMEAQKKVDEINRSQNDWTAVVYERFALMTEQQLRRLCGSETENENDHPKPQFKQAVAPIDYGDLPETFDARQKWPECADFIGTTTDQGACGSCWAVSAASTFTDRICIARLKKGIITDSKDPRAYVSAQYTMECAPETNRCKSGRATEAWKLYRKNGTVSGTDHAMLSGCKPYIVPSMSETEKNNTSCEKTCNINWLETQFGKESVPYEPFLIENLHMPRSNEPVRWWGTNDPNREPAMMREIMSNGPIQAGYLVYSDFFNCGQEGIYTRGAHTNSENGSGHSVKIIGWGEAEKDNQSVKYWLVVNSWGLAWCDNGLFKIRRGTDEAHFESWGITFGIPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX17</accession>
    <name>A0A914GX17_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GX17"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12134.t3">
        <property type="protein sequence ID" value="Gr19_v10_g12134.t3"/>
        <property type="gene ID" value="Gr19_v10_g12134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12134.t3"/>
        </source>
    </evidence>
    <sequence length="249" mass="28188" checksum="C2025990DEFCF7A6" modified="2023-02-22" version="1">MSKLPAAPNWSRRTGRPQNGTAPKKPRRTDPDRLTFSTVKIEMNFEYVDLKYELMFTSVGCACRPNTLGWCNVTSYILYAAQKDICIAGLDEVSAQYRLLETVEKAHSSEITFLTLSMATVVNAESEVYSLFCSATSSGELAIWKLRKTANDRATLIRRMKKDSNIELAKMGLFNSDRTQIVLGILQFDHIDVHILNLEDLWRACYGRRIVFWDGGSLCRGTELLFLPKEAFSRLVRQQIVGSFAGIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GX99</accession>
    <name>A0A914GX99_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914GX99"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12015.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12015.t1"/>
        <property type="gene ID" value="Gr19_v10_g12015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12015.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18559" checksum="930109BE3F666006" modified="2023-02-22" version="1">MVFFLYKHEAVGHDELRACFADLKRSNRIFDGGVFILFNGWSHQVHPFFQYYKRDAERTTKKALDHLKNIDKNQQQNRNFAFITCNVGDWEAWLEPTSSLRMDATLGVKIAPTLIEYSLEDGHCVEGQKLDSDEHFQTANDIVEFMLKRPLSNQEMMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GXR1</accession>
    <name>A0A914GXR1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GXR1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11742.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11742.t2"/>
        <property type="gene ID" value="Gr19_v10_g11742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11742.t2"/>
        </source>
    </evidence>
    <sequence length="184" mass="21481" checksum="9D80EF3BF4951E1B" modified="2023-02-22" version="1">MTRLAHPSTRLRQRGVTYAERRVVGYSAPQMFSIVNDVEQYPQFVNYCTTVRRHKDKQGRAAEYELDIKFMRFNERYTSRVIWLEPTVVHAHGTADGHLFHHLETTWRFGPSLQHAADTRTCTVHFSLQFDFRNQLYAFVSHLFFGSVVKNMVTDFLQRAHTLYGPPAPVDAEFAVPQILSYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY20</accession>
    <name>A0A914GY20_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GY20"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11831.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11831.t1"/>
        <property type="gene ID" value="Gr19_v10_g11831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF110">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11831.t1"/>
        </source>
    </evidence>
    <sequence length="528" mass="56900" checksum="C7EC27D887CB63AC" modified="2023-02-22" version="1">MVVPPGGGSAGAVLQWLRKNALVGATLVAVVLGALLGSIVRLGNPSSQTIMLLTFPGEILMHMLKMMIIPLIVSSLISGLAQLDAKQSGRVGSLAVAYYLATTAIAVITGIILVLCLHPGNPENHRAIVSTRELKRVSTVDTFLDLIRNMFPENIVQATMQQMETTYVFDVNNTDVPLKYKPVYKDGMNILGVIVFCISFGIVISQLGERARIMVDFFAVLDLVIMRLVSIIMWYSPIGICCLIMGRILDVEDMSNTARSLAMYSVTVLLGLAIHSLFSLPLLFFVLTRQNPFVFMRGLLQAWVTALGTASSAATLPITFRCLEENLGVDRRVTRFVLPVGATINMDGTALYEAVATIFIAQMNNVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLTAVGLPVNDVSLIIAVDWFLDRIRTSINVLGDAFGAGIVYHFTKDDLAKADAEHHKWPMPPGTGTESDGKDFLSISERRRSLVGQPDKKTFLVHGDEQQLQLLGNSTRHGHDDSPVPTNGGGGEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GY34</accession>
    <name>A0A914GY34_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g11844.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11844.t2"/>
        <property type="gene ID" value="Gr19_v10_g11844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1499"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1531"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1566"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1597"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1643"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1682"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1753"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="623"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="656"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="726"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="759"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="884"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="917"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1090"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1202"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1270"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1303"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="1540"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11844.t2"/>
        </source>
    </evidence>
    <sequence length="1851" mass="200512" checksum="E1FEC0F0AA8916FC" modified="2023-02-22" version="1">MEAVGEQLPFSNGSGGKKSAANANGSLSSRRHSAGGGGGILARALGHTRDSSLDDGSGGAEDSTAAPAAVVVVPSSAMAQQKQANDTATISSIDKIVGASDTALRVTVPTAIVTSPQNATRRMLSPEELEGKRRISVVDSSDDDYRYGILGKSLRQFNNGQLGDHRQRQFDTETSSSSGEGPPNASGRRVLATSIVPKRKRLGFYPSGDGANLPPATAGINSAVGIDSRARSIQVAEELRRAAIEGGGGGGGGRVDTAEQAERLESADGGGGGAVADDGGGGAEDGTLQARGGPGGGLTVADQEELAALELLSKGGDQGALLLLMAKQGNWEGVQQLLASGSQLDMTSSDTQGYTPLLLAVRAGFVDIVEMMLERSADLYAATKDRLTAAHICARWANEEMMQKLLALKIDISRTAGPLGRLPIHMCCERTSARALPIAQLLLHAAPGTRMQADKRGALPLHVALRVCNLLMVQLLLQRDGDKQIRVQDSDGNTAMHLCKNNDFLRAITDHGGTECVNVQNAFGRTPLHEVAKLGDDKMLKIMWKLNANANIMDKEEKTPLHVAAERGHTQVVETLIDKFGSSIRARTFDGSTLLHIASAAGHADTALAFLKRGVPLYMPNKSGALSLHAAAAAGYNDVVKMLIARGTKVDITTRDTYTALTVAVRSGQASVVETLLGFGADVHVKGGQIGETALHVAAGLPCGSIDCAQMLLKSGAQPNVQRAQDGCTPLHIAAAVGNRAICRLLLVEGADAHLKSKNGETALHLASKQCHFAIVQLLLEHLTKDSDSNRVRNYVNALTEDGQTCLHYASQIAPEQIHFKDEDAKIVSLLIDNGGDPELQGLNNLETAMHMCARSGNESILSAMVNKIGPGAVQIVQNKKSKNGWSPLLEACARGHVGVSRILLQHHARIDVFDDAGRTALHLASANGHIELTKLLLKYKAFVNSKAKNGEAPLHLAAQYGHARVVNMLVQEHGASLEAITLDNQTALHFSAKYGQLVVAQTLLALGANPNARDDKGQTPLHLAAENDFPDVVKLFLKMKQNNHAVLTAVDHSGFTCAHIAAMKGSLAVVKELMMIDKAMVIHAKTKTLEATTLHMAAGGGHAKIVKILLENGANPEDENANGMTPLSLAAWNGHSGILPCFERKYWRRCSKKTGLNAFHIAAYKGHSDFINEMIKCVPASVRSEPPMFNHLVMKEFATEYGFTPLHLAAQAGHDTLVRMLLNQGVQVDAATTTMNVIALHLAAQQGHIAVVGMLLSRSTQQQHAKDWRGRTPLHLASVNGKKDMVSLLIAQGSNINVMDQNGWTGMHFATKAGHIDVVKLFVMSSADAQAETKDGKVPLCFAAANNHIECLRFLLKQKHDTHQLMEDRKFIFDLMVCGKGNDNQPLQEFILHSPAPIDTAVKLSSLYREMSEKEKERAKDLSNVAIFAENLAVELLGISATKYNAALLLKAKDHRGRPLLDVLIENEQKEVVSYASVQRYLTEIWTGRVDWSFGKTVAFAFFVLVCPPAWFYFSLPLDSRIGRAPIIKFVCHIVSHVYFTILLTIVVLNITHKIYEMTSVVPNWVEWLLLLWLSGNLVSELSNVGGGSGLGVVKILILVLAAIAIAVHILAFLLPAIYLTHLDNDEKLHFARTMLYLKNQLLAFALLFAFVEFLDFLTVHHLFGPWAIIIRDLMYDLTRFLVILMLFVAGFTLHVTSIFQPAYQPVDEDSAELMRLASPSQTLEMLFFSLFGLVEPDSMPPLHLVPDFAKIVLKFLFGIYMMVTLIVLINLLIAMMSDTYQRIQAQSDKEWKFGRAILIRQMNKRSATPSPINMLTKCYIVLKVAWRNKLHFCTQKAQQDLRLLANPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ79</accession>
    <name>A0A914GZ79_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZ79"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11754.t1">
        <property type="protein sequence ID" value="Gr19_v10_g11754.t1"/>
        <property type="gene ID" value="Gr19_v10_g11754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000007">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11754.t1"/>
        </source>
    </evidence>
    <sequence length="422" mass="47321" checksum="CE8DD8B697FD6D06" modified="2023-02-22" version="1">MATQRPWIRRDPVSLATFSRFKLLSQAAAETTAKYKWSERWHQMPIDHFSFSDTRTFRLRYLLNTDHFREKNAPIFFYTGNEGGIEGFAENTGFMWDIAPEFGAAIVFAEHRFYGKTQPFGNESYTKLDNLGYLSSEQALADFAHLIYHLKNEILPNAKNSPVIGFGGSYGGMLTAWMRVKYPHIMDGGIASSAPVFWFPNVPSPPEDAYDKIVTRTFVNSGCTVAGIKNSTDAIKELAKTGKKIFPMGRRFLNEKFHLSKKAQVQSPSDGALLASSIKDVMETLTMVDYPYPSNFLAPLPGWPVKEACKAYSTALGSERGHALAAYAMLNIFYNYTGHQSELCLFGKDCPGTFSELGDPDGWPWQSCTEMVMPMCSEGPPRDPFSLSCPYNVGYNGFLFRPQWAMINYGTFYPTASNIVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914GZ86</accession>
    <name>A0A914GZ86_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polycomb protein VEFS-Box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914GZ86"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12482.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12482.t1"/>
        <property type="gene ID" value="Gr19_v10_g12482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
        <property type="entry name" value="VEFS-Box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Polycomb protein VEFS-Box" evidence="8">
        <location>
            <begin position="459"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12482.t1"/>
        </source>
    </evidence>
    <sequence length="730" mass="81825" checksum="37B987A51F4E3F98" modified="2023-02-22" version="1">MAEYLVVRVVFRFEDAEIGGRHLRKVPSRQSSSGTTDCPNQQHCLRKNGPADDRHREVVMFGAKRIFSFNPGGDLKVINDEASIDLFSDAQLQFSELNSSKLSAAQLSRLIHGNLKPLGGSSPFITVRSHGDSDDDDEEEDEQEEEGNGTRNGEGIGSSTVGNVKIGPKLKKRKIGVNGLEHDDTVDERQNMDSGEGLSLREALEAMDMADNNSGTTAASSTNGLLELPKVIGLKFWLHSPCTARGAVRSSASQLPPGSPPGQQRRRLFVRTAAAVANISLGLFSADERPQPSADRWDASTSSDSVSSSFLLNAPTSLNPSSSSAVSPPFVCRPFPTSHCFFCLASLRLRNLWALQKHLTFCHPRFDFSYETSIRVSPTECLPGFSVTQNVKFDSSNELRSARTAVRPTWLVTKALANKMRTVDNFPIERYTAVASGLSTAEEYIRTKGRFNFETPARIDQPWMRQMSIRKLNDITDLHPAECAMMQMWNTFLLRIRITLFGRRMLYKALRVFVKDSRGEIDRQHLRTHFLLHLTCLLNAGGIDEEERYDLYRRLEHDYDPCGDSRHFVGRELKALEKELRTLSQQQHLVAKSSSISKGHNKIDKLHRGESHQNRLGWRMELRHQQQNISTITAATRLNGGTFKKTVAVAERLQPHRRLLSPSHNVSSSSLCGSSSHFNSCQELRERFAFASSKRIALLWKFLQNYDCPADDFNAYTTNNALPQQKTVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0M1</accession>
    <name>A0A914H0M1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H0M1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12841.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12841.t1"/>
        <property type="gene ID" value="Gr19_v10_g12841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF21">
        <property type="entry name" value="CERAMIDE SYNTHASE HYL-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="10">
        <location>
            <begin position="93"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12841.t1"/>
        </source>
    </evidence>
    <sequence length="333" mass="39346" checksum="E0256ACF1C645E1F" modified="2023-02-22" version="1">MSSIIWNEYIWLPPNMTWADLESRGGMNYPQFRELSYAFLAACIITFIRILTEALVFLPIGYYGGWMDRKKGSIYHRILDHLFFGFAGRSKFKRVAETAWRFTYYAIIWLVGMAVLYNEPQFSSVIECFREWPKHHLPNNVWLYFIVQSGFYLSLLFSLVVFDVRRSDHYEMATHHVATILLLSMSFTINFVRAATLILILHDSADVFLELGKLFRYAGWDRAVTIDFCVFMLVWVGTRLVVFPLKLVRHMLFDAPRLIMESYRWTDLFQKPIIPRVFLAVLFILLLLHIFWTYLLVKIAIKSVKSGVDDIREESESEEEVEREKLKKSRKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H0Q7</accession>
    <name>A0A914H0Q7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H0Q7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12553.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12553.t1"/>
        <property type="gene ID" value="Gr19_v10_g12553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12553.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11601" checksum="6DFD8979108034FF" modified="2023-02-22" version="1">MWEHALAMPKAALDSWLNKDLPRLKGMVQGLGQLLRDQFDGEAIMCQNRYNGCVNFLTKCDNRLKVLIASLKELRNKMANIFEFHLTTRANLLFPNLLGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H132</accession>
    <name>A0A914H132_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H132"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13181.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13181.t1"/>
        <property type="gene ID" value="Gr19_v10_g13181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="204"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="549"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13181.t1"/>
        </source>
    </evidence>
    <sequence length="837" mass="94623" checksum="B873248464C6CBC1" modified="2023-02-22" version="1">MNSNGTNGQQKLLDKFKGRDKVHDGCSNAYLFEFRPGSVTYRYDVKITQVFEKTDMFGKQAEGGCLYVYDCMSTLYTNVQVDEISLELDAQVFPDELRVLFQKGNLWTECRADFSGSATSSNRSLRTFLELLTSQPFINAGTHFFAGNGELFESVAERELGDAIALHKGFRKSVMVVSNEGKPTAALFIDVKRCLFFNSVTGGDCVRQVAQRWKGPLGVQFWEKWVGLYQGVRAFLCYKPCRTIVIGGLTQESSREKRLTVDGHEMSLAEFFRERKKVTLQHADWPAVIPKAPSEMGVFPLEQISIMPNQRVPQLKFNGYLSSQLINANVVTPNLRFQAIENVALQIGHAKGHGEFLKSFGVKMSGRNNVVPLNFHGGAVVRFGEQKTVDTEQGKFDHGRFCKFYRSGELKNWVVGHPSAVEETIVNKFIKSLIESSRHLGFLLPFPQFTNVEISELEQKMGKFAADGKQFFMYIDKKESPSHSPLKLYEQIHRLMTQQVTSEVAAVAGQVTLCNIVNKMNMKLFGLNHIPIFEPIAEKRFKLGSGNVLVVGYDASHAPRATTEELAAMRRRGIQATSMEPDVIGFCANYLKEPNNFCGDYFFQPAKQDICHPEHFKAKVSWMLRKLKAKRERPPSIIFIIRDGLDEGKVDNAMSSEIRLFRESCSQISNTWKPKFVYCLADKRHNRRFFEVEGRLPDASQPLNVFNPQPGSAVDRKLIRPDVLNLYVQAHQPVRGTAKIPEFLFPCNEVCATKEELEAFINGLCHSWQIVKAATSLPVPVYQAHELAKRGRANYMELRRMAPERIPRSSDGQVLCEKLSELLSYNDSPLSDTRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H184</accession>
    <name>A0A914H184_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">THO complex subunit 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H184"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g12313.t1">
        <property type="protein sequence ID" value="Gr19_v10_g12313.t1"/>
        <property type="gene ID" value="Gr19_v10_g12313"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g12313.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23624" checksum="0DBEEB378B872D92" modified="2023-02-22" version="1">MAEEAIIRKLIADGDGTGDDRRIVQLFQLITMLNKANSDTKSITHKILTNLDLIELSFQKQSQISAVTEEEIVNYERLCTEIDQMITQNSDKMEAVKKELAEAKQIRKNRQEYDALAKLIKEKPSRADTSRKLKGLQDELEEAYAKQKILEQRLIEKRKNMYTLAVLLDNLDEMNKETEDVPISEGEDASAIPTVLSKSTGPEKPSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2E8</accession>
    <name>A0A914H2E8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H2E8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13045.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13045.t1"/>
        <property type="gene ID" value="Gr19_v10_g13045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13045.t1"/>
        </source>
    </evidence>
    <sequence length="480" mass="55544" checksum="7043E5FE28BDDA77" modified="2023-02-22" version="1">MVKVSPAEPERYHLRLLLLNVKGACSYDELKTVVESDGSVKVLDMMPGEEIVYKSIDRAEDENRQRADEYLDEYLNALNPSGSDFFGRQHLRRYIWADIFAPATGLRACYLLLVGSGNRMEEIWILILVLFFATNSLDKAESSLITLIMPKMIKTELKRAGFKNSYEHEIDENVAKELGLSFATIYRWKRKLGQTTANKYAHDKQKEFLMKSYYEIKGKNPKIRDEDIAKTLKIGTIASKFCRGRECRAESVELEETPPKMFDEIFGEGWWDNGKADEWRKLTLEHNFHRQINRQNTQIGQIGPDSTDQNPPLTESDHFGQIEPNSTDQLGHIEPNSTDQLGQIKPNSTDQNPPLTESDHSVNAKNGEDQNEITSNAEDERKHKTVAKELGLSFATIYNWKRKLGQTTLKHKHSHSEQKELMNRYYEIKDKTPKLRDEEIAKMLKIGSATLIRWKRQFKRQQFYPNVVDELFVEDRGIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H2G4</accession>
    <name>A0A914H2G4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H2G4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13522.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13522.t2"/>
        <property type="gene ID" value="Gr19_v10_g13522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF21">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="88"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="301"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13522.t2"/>
        </source>
    </evidence>
    <sequence length="476" mass="51806" checksum="8722F35F40F1B565" modified="2023-02-22" version="1">MDQVHIDEAPASENRFSDHSKDENCTALSQCGGKNPPERKEESPRSFIVETVVPFVLAGFSMVGAGALLFHASKTHFIVKMPVVLVLVPALLGLKGNLEMTMSSRLSTMANLGQLDVPLRQLFAMLFSNIAVNQTQAIIVAMIASLVAITTDLLDGNGFDSARSLCLVVSATVSCSVTSMMLTSLMVFIVITARRCGLNPDNIVTPLAAATGDVVSLSFLILFGNWFFKLYEKYLEALVIFFYLVIISLPMWTFVAVLTPATRNVLKHGWYAILIAMLISISGGYILRHAVDSFPSATLLQPVINGVGGNLVAVQASRLATYLHQFGKQGILPANTLVTYANPFRTFACKERESNNAVILLMMSVPGHVLFIGMLLLTGKTNELPNWSFFLLFLCATTLQVATLLYCCQLLCRCLWRFRLNPDLSAIPLLTAFGDFLGAGLLALAFIIHAAASPEIYNSANQQNSTTMTVYPTISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H362</accession>
    <name>A0A914H362_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H362"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13223.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13223.t1"/>
        <property type="gene ID" value="Gr19_v10_g13223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037938635" evidence="1">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13223.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9476" checksum="D719C7F5C4DE16C0" modified="2023-02-22" version="1">MRFWVAASVLFAIVVVSLGRASEQQNRDDLRAKRQICQGFSSQYSACILQKYDQCVWCNDADYRGPHRCDVKSAMKGCLQILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H381</accession>
    <name>A0A914H381_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Histone-lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H381"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13581.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13581.t1"/>
        <property type="gene ID" value="Gr19_v10_g13581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="152"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="11">
        <location>
            <begin position="312"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="380"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="12">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13581.t1"/>
        </source>
    </evidence>
    <sequence length="527" mass="60928" checksum="2CACAA4CB1C88545" modified="2023-02-22" version="1">MFTKEYRIIMPISVKEFQISHVFTVAAASTQETGGGEGVQVLRNRARIERQMKRQNGFNLDLAVCNTRWDTATSATIGQLEAVRLAVGVEGEKQMKRLFGGVPNSDHAEEVRLGPHVDIPMTKKLLNDSSSASSSVDGNHDVMRPVTEDNQWVVEKILKKRVTVENKKRVVSYLLKWVGWDYNLSTWEEHNQDNNLDKLVKKFERRSKWRKTIYERESRSCQASMFKHNNRFKCTYMNWMFNRPVFNACHRWEDEMNGTIRQWKTSSKCKKAPIYVENWVDDEFPPTNFEFILENIFSESVEQAMMGFMKLEFCMCKANGITCGAVEDCCSEIFGQQYCYGEDSKLVSGRARKNWIVECTDGCSCDINCPSRVVQRGRQIPLVIFRTVDRGWSVRTTISIERHKFVCEYVGQVLTVDEAFMKNMPSTYQFQMDGAGEHKLKFVVDAFNSGNEARFINHSCSPNLDVRPVFADRLDECYHRIAFFAKRDIKIGEELTIDYCAIDGNAQGRQKTKCNCRALKCRGFFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3M9</accession>
    <name>A0A914H3M9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3M9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13695.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13695.t1"/>
        <property type="gene ID" value="Gr19_v10_g13695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13695.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11465" checksum="A89E6CAD8C8DA49B" modified="2023-02-22" version="1">MSRRESGRQDESTIAGLAGAQSTAGVHTQALGDSVRSRSRAASNGSSVVVCDTRSRWCSKHAQLLDRRRGVGCRLRKWIQFPAVAPKNLSQTPVVMVATVVGGDAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3P8</accession>
    <name>A0A914H3P8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3P8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13361.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13361.t2"/>
        <property type="gene ID" value="Gr19_v10_g13361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF263">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037976500" evidence="10">
        <location>
            <begin position="30"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="61"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="172"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13361.t2"/>
        </source>
    </evidence>
    <sequence length="690" mass="76526" checksum="71AFB0F370431F07" modified="2023-02-22" version="1">MKQHFASTRCPLQLFFFSVLTGVSVFASAQIGRRNASDESLNISLYSNSVQPQPFCVLEKDRSAVYMSIPENTSKGAILGTLPIFGLTSGPKPNIRLRIVKGREYVRLNALSKQFVLRKEIDREQKEMGRFEAIVECVPLAPVPSKSGLFPLNISVFVTVIDVNDNAPQFAQGSQFNVQIPEELPKGTPIKLDFRATDSDQAGPNSHIRYRIVRSAENKSFDEVFAQSSAEDQGMPKLRSFARLDVKVIDVDDLNPIFSSQMYRSNGLRGSKLVIDPSPIRAWDADRLFDEPIFYTLSGDNSLNYSIDELTGEVKLLAEKLVPANLIVQARQANRPERNATAFLLVESLTEANGGKESSEFIFLRFPSNTAIGTKLMHLVEGKGTSETLELLEPKEQRLSSLPFYVDEKTKWLRLSKRLPSGQYEANVSIKLTSPKRPPAIRSLHIRLTVADPMINGVGSLGFKKSIYEFEMSERGRNGGESVEIGRVRAERLKGTDCRNGTSPTEGEGPVIFFDIDPTEGILRLRSPPVTDELPPEVSELVVLAENAEGSRAFARCFVRRAGGLFLMAPNAALPLGLLCFLLLLSNCTTLSLWLSKRRFATLYDQLAYRYDSMGVNEAKFHPNHNSNSSNSAETKSRSGGWMLNRSLEGDATVAITNWESKTSRMNTAGSAFECGREGDKWMKGIGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3Q8</accession>
    <name>A0A914H3Q8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H3Q8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g1337.t1">
        <property type="protein sequence ID" value="Gr19_v10_g1337.t1"/>
        <property type="gene ID" value="Gr19_v10_g1337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="10">
        <location>
            <begin position="57"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="253"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="560"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="671"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g1337.t1"/>
        </source>
    </evidence>
    <sequence length="714" mass="79714" checksum="94DF91BD18C948AA" modified="2023-02-22" version="1">MPPILPSSFIHRLPNFFVQFGYRPFCSSTTRFTNDTSDSDQGGDDANFFEGLYFAGEIPRDRIKQKFTLASGPGGSNINKNPTKAEIRFLVEKADWIPRRVRERLVERHPGCVNKRGEFAFTSQITRYQHQNMEDCFRRLHNMLLDCSEDLVREVHREYVSPDHVKELELRKERSEEYRLAGKSQNSRKKQNQIGHINRMESAADDPQVSGAIQRIAAKKAGISWQKPKLSNSSVNAHGCRRRCFYLSRASRLLLMIALTFAFFLIELVFGYISHSMALIADSFHMMSDVIALCIAFGCLKIAERRKSSKNTFGWVRAEVLGALVNGVFLLALCFTIFIESVQRLLKPEPIKNPVNVLIVGLIGFFINLIGMIMFRGHVGHTHAAHGVEDVRSEVHEVVTEAAAAAMAADGCGVSPLLVATADERRRRRHKQQRQGNNGGKEYNDDDEEDNRVISMSELEAVEESLMSRAPPRSKNSKSPHGSHLNMHAVFLHVLSDAVGSVIVIATALVAWKVEGYEVLKLYMDPLLSIILVCLMVCTTFPLVRETALILLQTTPSFVSIDSLQAELLGIDGIVAVHEFHVWRLVGERIIATVHIRFRTLRDYVLAAEQIRSLFHDNHIHSTTIQPEWTPSANVSELECAFACLPNNCNVLESVDVTCCGKDKRTPPKKFVHASTSVTIEEEQQQQPNAASNGGGGGNGSNNCSSSASSSTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H3U3</accession>
    <name>A0A914H3U3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H3U3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13001.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13001.t1"/>
        <property type="gene ID" value="Gr19_v10_g13001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13001.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8423" checksum="8A254A8F5B583717" modified="2023-02-22" version="1">MLCQISVKYFFNFIVPVNCRRNAGRLEGINSMKVSTAYDNHRADDKTKGVVIFYCGPCWDETKMMRIGRELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H466</accession>
    <name>A0A914H466_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H466"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13684.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13684.t1"/>
        <property type="gene ID" value="Gr19_v10_g13684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13684.t1"/>
        </source>
    </evidence>
    <sequence length="576" mass="64614" checksum="29117BEF78CF5682" modified="2023-02-22" version="1">MSCPKRISEQSALAFNSALNVFAVPPTNVSVSRSFFRELLPLSTISQEGPYLFRMFNDSLWADLSRVYLYLELSIKKPNAHGVDVPIDASDDADVGPCQSIGQTFVQQLKVEVQNTELYDSGTLYPYKAYITNELSFPDNVKRNFMASSGYYPSLTHDDRNDTGFRQRCSRFAGGRKAQFFSRLDFDLGNQELYLLSNMDILFTIYRARNSFLLQCLAQNVAAGRQYSLFVHDIKLYVKMVEVQPSLNMSIYKTLEKQPATYAVRRTEVKSCFLTAGRTELDHAVFSAAIPRRITIALVINRAFNGAYALSPFDFRPYNIRDISVHAGGNVYPAVPHRMNFKGADYVRPFVDMYEALGMANSERSMDISLEQFRDGWTFFVVPMTSTLDDSCGFELLRSGTTSVRLQFNEEVPPGGVEMICLANESFPAPMQTLLTLDRPEPDAWRDTPTLQRTLHALVLLLHYSVVLPLFALCCLILLRWMRKRGLLVDRRRNPPNSASSGNSPPKPDTGAGNRHHQIPSPVAPNAPSTPHNKDDDADDAEDRADVELVRGATAAAASYILPRIIFLNKMDGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4G5</accession>
    <name>A0A914H4G5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H4G5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13159.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13159.t1"/>
        <property type="gene ID" value="Gr19_v10_g13159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13159.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33347" checksum="1875C41C08EC217B" modified="2023-02-22" version="1">MVQEFNTTVNIPPPLPLRPNSPNPSMSSKSNCEDEEKWRHLMENHHELCDLEKCLGKRINGLFVCQFSNIPGHLYSQYLRHRRRQGAYKTKPCRNFYGPNRFCPAGDRCSFFHEMDEKRELLHQPTTTTNFVMNNDRDNIDPSMHPFAFELFNEEHTSVMFDNNNEQQQQTLNNLILLVTETYQRMCKQVISTDEYLLSMKNTHQMHQKPKHWPFNLPLLAADGTGFERNCAAAYQTKKKDKTQYSVVNPTNSWEECSATTESSRSLSPTAPPVMRSKGSWRLNPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4K5</accession>
    <name>A0A914H4K5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="10">PARP</shortName>
            <ecNumber evidence="10">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914H4K5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13186.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13186.t1"/>
        <property type="gene ID" value="Gr19_v10_g13186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WGR" evidence="14">
        <location>
            <begin position="579"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="13">
        <location>
            <begin position="711"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="12">
        <location>
            <begin position="830"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="469"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13186.t1"/>
        </source>
    </evidence>
    <sequence length="1069" mass="122995" checksum="9E402690942AF4AE" modified="2023-02-22" version="1">MDNRGMPLLMITGYPSCGKSTICARIFSYFEEHNLGENLYIVSDEGIDSNFSRLIYDDLKKEKEVRSALRAKVQRLLDKKSLVICDSTNHIKGYRYELYCLAKNTQTRFAVIHCKASFSTCKWLNAQREDTGRYSDSILFNLLKRFEAPEQKNRWDSPLFEINIGGESAIKSIEMRDEFGIITEDANDCALAENFGKMSETELPRNVNLPLEQIYATLVKGKELSANKCMKLQIPQILDRLLALQRRATVGDTLTVLDGERGHANGVAFSRIRPLPQLSRLRHQFAMSNFQIVWEYQCSPAKWVEFERGLATFLDGFLNDSGGSGFEFEGRKVIFDLRLMRQCDSEGRVTRNIRCAVRPTGGGAQVKFVWSYQYGPRKRWISFPADLSLKLEEKFGCVSPTKIVRDQKMEFTLNEGPSQIMRRGKYSLINEEGTAKIKNGRSLYLEKDKEKMGGSEGKVERKVMRKMKVDEVEEEVKRKKEAGEVVEVEVKRKKKAEEVVEVEVKRKKKAEEVVEVEVKRKKVEEEVKRKKKKAEEVEEEVKRKEKAEEIEHLDENESKLNGVQSDVEVDAECRELRATVRVYVDEKGRCYDVMLNQTDIHQNNNKFYLMQLLCDITAKDKIWLWRRWGRVGFRGQSNLIPFGSEFDGALTMFLNKFSDKTRNDFLEGTENFQKVAGKYDLIKIDHDRRKATEKKIGVKLRQNVSPTESKALVMDDRVRALLTTICDLKAMECDARRLEYDFKRIPLGKITKEQLNFGYEALSRIERQIQKANFGREFVEAMNDYYTRIPHSFGMRTPPPIKSPEELNRETELLEMLTGIEITVANIGGDPLECHYARLRWNLIPLEREDENYKIVEEYLRETHGPTHDRYQLKLRNVFEFKPKGTVDGKRAEGIDGTRKEIGVGNRKLLWHGSHLANWYSILAQGLRIAPPEAPSTGFMFGKGVYFADISSKSANYSLCDPDKPGFLLLSDVALGEVLDLKEADSNMHKKLPEGKNSVKGVGRYVPLPNGGRKIDGNVEVPCGKPTQNAELDAEDETSLIYNEFVVYNLDQIRERFLVEVEYIFDFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H4R6</accession>
    <name>A0A914H4R6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">guanylate cyclase</fullName>
            <ecNumber evidence="6">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13232.t2">
        <property type="protein sequence ID" value="Gr19_v10_g13232.t2"/>
        <property type="gene ID" value="Gr19_v10_g13232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="20" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="26">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="26">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="26">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="25">
        <location>
            <begin position="1023"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="119"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="397"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1226"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1239"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13232.t2"/>
        </source>
    </evidence>
    <sequence length="1310" mass="146654" checksum="0B070F43EF70922C" modified="2023-02-22" version="1">MPKSLLLKQKCVSVKRRIPDGWPGLGMMPWLPGGKGCGERMGWANDGCDKAWDANAKEKRSPVPFFQLETINANRDGCANFKKHLKVILRCFLIDSLLEERQKKLAASVAAKREANGFNPEECEREKEVGKESTMPDLHMEDKETINDQKNGTTDSEETANEEVLPTFDEDKETDNRVPTNHSDQRMGQEEVGSDRKQRRALLEALVKLEPVAVRQGEKTERETDGEAESVEEGGETALSSTTVSAEFLHKFRLFQQQLASTASFSGGWPLISTNHSPIPANFVRLPFAPFSLLINNSNNHPPKSFASNSWRPSMPSISMPSVAKRRVKATNGKVGNEAQTMRSNDASQGNFLPAWAAPSFLNVPNVSNGSVTAMLASIGAFRAAAAAAVVSASMHNDGTNLNRNSPIPSRPDERELRGAKLPNNSGRIGRRPSTSAQQRQQQRHLLPHGRIGRSSNAKKYRCDICDKTFSRSNTLITHKRIHTGEKPFRCEHCGRAFRQPGNLTRHAYTHTTVKPFVCAECGKAFNRASNLQSHVRVHAAVSGKSGENSGGATRQFDSDQRLTTTIPCRAGLSLQLVNARAPFHELKKGEKFGWVHESFRQLVTRKHGKEIWTKILEIAKFEEGTENEISKYYKDEESFRLVSAMGSVIGIPVEEVWEAYGGFLIQFTMETGWDELLRALSPDLEGFLDALDALHYFIDHVVYRTKLKGPAFRCEPQPDGSLILHYYSRRSGLYPIVKEVARRIYDTEVIMQVQERKQEHVDSMITEHVTFVISQVENNMSVSRSIASRTPLNTCISSIESSSSVNSTRIEDFCVAFPHHFCFDRQLRIEHVGAHIRRAYPNIVHGETHLEDILTLVHPEIPLSFDTIMTFRNSLFVFQLRDESSKGDSKPNSVRSVESRGHIPVTLKGSMHSVSSNKYMLFMCSLNVTTVHELVERNLFLSDIQRHDSTRDLIMLNQSRMSQVELNRRLEETTRTLKSMASALKAEKQRTEELLCELMPPSVAESLRQGTTVEAAEFPDATVLFTDIVTFTNICSYCTPYDVINLLNDLYQRFDRIVGLHDVYKVETIGDAYMIVGGVPKECRNHAEKILNVAIGFLMESRFVANPTTKLSIFIRIGVHSGSVVAGVVGVKMPRYCLFGDTIHLANRMESLGVPSKMHVSETARALAVKSNPSFLFTERGTIKIKGKEMFRTYFLERNDRKSVWEICGRVRTISQSIDGYQELHGEKTSECEESEEADGKGKKKQNENAERDAGDGGSGKAGATNEEEWNKIEGDIGDDNVERKKKSEKNESNGQIAAKARSKACSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H5T6</accession>
    <name>A0A914H5T6_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914H5T6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g13486.t1">
        <property type="protein sequence ID" value="Gr19_v10_g13486.t1"/>
        <property type="gene ID" value="Gr19_v10_g13486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g13486.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35560" checksum="2ABB06C28D29BF00" modified="2023-02-22" version="1">MMSNAAKNILGTPTIHNNANFNATITAQLLHKAIGEKNKDEVIRLLCTISNQQRQEVVVEFKSLFEELILALLELPSVFEARQLYKAMSGLMGTKESVLIEILTTHSNRQIGEMKRVYEKLYGHPLEKDIVGDTSGPFQHLLVSLCNESRDESWNTDPLRANMVARTLFKKSEVESGVDDAVFNQVLANENFNQLHLIFTEYEKVSGHTIDQAIQQQFSGETRDGFMAVVECVRNRHAFFAKLLQNATKGFFGIGNLGIGTRDSDLIRLIVSRAECDMAEIKDQYMQMYNTTLENAIEKNCSGSYKEGLLTLIKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914H7J4</accession>
    <name>A0A914H7J4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914H7J4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g14441.t1">
        <property type="protein sequence ID" value="Gr19_v10_g14441.t1"/>
        <property type="gene ID" value="Gr19_v10_g14441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g14441.t1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39526" checksum="C1115C325B57F4EF" modified="2023-02-22" version="1">MMNQRRNTVPPSEDAIEKIKKVLNDPLPPSTTDKYAEMLNRLRKLNLGSEYDNFLKNLAKKFSTNYPPDNDDDGGGAGGASQYSTDNNDIARAAAQLFIVGQQNSEQADLMFLPSGAARNIFFLTRNAVGNFLSSDGQPRLLSMSNVMKEQQPLDLFFVRPHEAKVLSFIRPLESGTGPKAYGVIVMVVPEGATAEERRESFKKTQWAANRLNRAILKHYGVDSIEKLPCAQVLDLMEKHADAGRIQKDAWLDVTAVLNTEFPGDIPFGGFKVQQVQTRWKNLQQAGKEDAQKAKKYARGTGGGPEAPKISDSSAKVIEMFGSSASFSGVPGGAETGTWPCFAIYFFMSIFSPIVVRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HAM4</accession>
    <name>A0A914HAM4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HAM4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15755.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15755.t1"/>
        <property type="gene ID" value="Gr19_v10_g15755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15755.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10846" checksum="F595AFB8FBABD727" modified="2023-02-22" version="1">MSAVSKSLKPILQIGARLGIQEKKNQLAQKIGPYFDSEHFGKKNTGYLILTISAFLFYKFSSTLTKKRVTAEKQKLEMKPYAVQEALARSGRVFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HB45</accession>
    <name>A0A914HB45_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HB45"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15730.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15730.t1"/>
        <property type="gene ID" value="Gr19_v10_g15730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15730.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40248" checksum="6BB6F9DD5BAEDF18" modified="2023-02-22" version="1">MANLTFILQVQNSVMTPCLKCSEEDGSFFQLENTKVAGYCRECFSKMIRQKFAFCLGKNRVFKEERRRDALLVYYSGAFESLQLLRLVCEAVTDQKVHKRLRLNAQVLYLSSATTLDKMMQDSEHCRLISHNFPDYWIWHFAHESAILNDTCIENSEQNLRCCSLEEVENLQLYNKLFESCQSNSVRDELKRLFRTKLICRKVQMFDCFVHFVSAEMSSMVDSRFEPIQLVRPLRDISDRELKAMLHIDQNGINQPAINENAGMIMKGGESSLQTLTADFIQELRGGGFPATISTILSVASKVENKDVGRISVDEGSALAIATDKHFCQICAQLLSDFAPNSGGINVERFLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HBM3</accession>
    <name>A0A914HBM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HBM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15610.t3">
        <property type="protein sequence ID" value="Gr19_v10_g15610.t3"/>
        <property type="gene ID" value="Gr19_v10_g15610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="747"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15610.t3"/>
        </source>
    </evidence>
    <sequence length="1116" mass="127653" checksum="879EA5BFEAE1B283" modified="2023-02-22" version="1">MSSSNNRQQIYYQGRHHQQQSQQNRIGGLSLSSTHHQMGPASPHQDHHQVVVVSGSGSCTGCVADYHSSCGCPSCESKNLATLGHETSLSDHDQQMYSYMDQGQLDDDDEGIVHEFTTDSGERHVVIMTKTDEQQQEGVISLQERVRRQKLSEAARSRYAQLSEDEKRAVTERRIIMRQRRKQKEREMEELEAILRASNDITDDLVPMDESMNMDERREYNQKRRLRQLGLPENINELEPNKLEGIRRHIADVNARKAEAARQRYHRMAHDERKTYNRRRTESFRKRRVEEEKLLSTPAGQITPEALEKAQNIMIRNAKRAEQARLRYQRKQQEKGIMPRRQRKPKIEYRPSSGEPNLDRILDTIERDVIEPKKEDMAEHEQMFTPPADSSNTMPQVLHVPHSGQNVVQYVQVPAQGVQNGLILTESKFMPSDSSEAKSSSHAPYTLDNSVQKFERGVGSASSSNNYYPVSIIQHEWPQRTSVVGSHHQLQSMGRPARIEIVQPTIISTSQGNFNQQQTHHYTIQLDQNQSTSQHRLLPSSSRNLQSGRASPADEKVMVQRAKRAERARRRYHEMTAEARHEFNAKRAHALKMARLRDEELCRLGDDLHSKGEEPDQTLCLAIEQARMRRAKSQPDKNRNFRAEAARIKYQMTGEQRKAHNAMRDAQRRQRKREMEDTVTFILLCWLGKFPHGAKRPAKETYSLDVSMVFNRKERLQISKKIGKQQQRGGGGGRRLSNQKVNWRLLNSEKRKQREKQTIEEFEERLNDGTKTEENGREEEAGLKANEPNSSATDSQSWGATTTTETPRYSLTVALPGTILDNVQTVELKTYLSGELARTLAIFCVEEVVVFDETAAMSQKDVDAYRDWTGGSEQLDARSSESVFFMARILEFQECPQYLRKALFRIQRPLKFSALLNPLNALHHLRSNELHSPFREGVVLDRKSNKGLLCDVGLEKELLLKTDDQIEPFSRVTVRIDQQQQKSSKKLRGSLANARTVREETGTYWGYSVRLARSLSQVLVDGSYDAIVGTSERGMPIGELSIPRESDSNCKILVVFGGLSGLEAAMDADPSIQETEPVKYFQHYVNCLPGQGSRVIRTEEAIPIALTALKYKLDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCF9</accession>
    <name>A0A914HCF9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCF9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16236.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16236.t1"/>
        <property type="gene ID" value="Gr19_v10_g16236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16236.t1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41262" checksum="D375E32944AAFBA5" modified="2023-02-22" version="1">MAKFPSLWYFDVGGTAPEGRRQETTDRKIDVGKLSKMQFLKNPALKNNSYCAGSHFDQKATRRNNLMATEGHGPVNRMAKSTKMQTYLNICVILITFLKTLNAHPKGKNVITDDQTPDESDWSKRSDNSKIIHAAFPEIPKKAEDFLETFSEDGEERIKIKWDKYDEEIASVNNQEHGRSILSASSSYGVSGTASESADDQMENEKTLDERKVHRNYIEIDRNMYQCEDFYASLWEDNDELDNYSKIAQIGNSSNEITTNNEEEPDVHSKRSETSMIVRQTKIFELMENFTHQKNFLKVWRTRELQQLIAKALTMRKLLAKKMLRSRQPKIAANNSPKQYGAACAKALESSEPPARAAVVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCH4</accession>
    <name>A0A914HCH4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCH4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15346.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15346.t1"/>
        <property type="gene ID" value="Gr19_v10_g15346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15346.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14185" checksum="B89207742E77ADEE" modified="2023-02-22" version="1">MSNLIGAAIGGQEEDNSKSVEELLRELVERNHNDEAISIDWLDQMLEVRECIRRECSRSASPAIRVRIHELIEAQQAHQRPQYEAIKEQLYGCLCRLRTQEFPYDWEEGATRWAQLPSSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCH6</accession>
    <name>A0A914HCH6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galectin</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HCH6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16087.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16087.t2"/>
        <property type="gene ID" value="Gr19_v10_g16087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16087.t2"/>
        </source>
    </evidence>
    <sequence length="216" mass="24962" checksum="A0044B0F4D6F0AC2" modified="2023-02-22" version="1">MFGQQNYKLQEQELTPWKRIPNIQQGTKVIFQVKLHSIEDGFRISFLHNRIQSSKAGDSIGAGIEIINVQPKDSVIVPEYYVVKRKLHSGGQKYQLDKQHKFKAQNAYEFVIVVHSNKYEIILNNNCLNHNATLPFWATNFVAIDGNVTLLANPEVVPPKCKRHTNELRRMITIRHEHYSRMTNSSVSPGGLSTDRYYAQIGQRNKIVLMESWPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HCS8</accession>
    <name>A0A914HCS8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cullin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HCS8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15859.t2">
        <property type="protein sequence ID" value="Gr19_v10_g15859.t2"/>
        <property type="gene ID" value="Gr19_v10_g15859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="404"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15859.t2"/>
        </source>
    </evidence>
    <sequence length="775" mass="89482" checksum="A0A2ACC5820F8F7D" modified="2023-02-22" version="1">MNLRPKAVNFEDVWSKLRETLEAIICLKPIERITWDHNFSDIYFVCVSVPEAQSRRLYMAVKKCLERHAAEIKESLLLLSGDRLLSAYNSEWEKFHKGAICLHNLYGYLNKQLTKEKMDAESQHTFMADTDRDGQCPHLGVGDLAFSIWRNGLIRPLAPQLVSHIIELIGRLRTGVSSSIGIRISDIRGAVLSFVAVNESIQQEQRTQLLCLSTGIPLTEFYEEIFERHFLEASENYYRTLTNETFAHLDCCPYMESVIQKTNEERSLVQRLLHYSTLPKVEQLCSELLVNDQLEKISIMCREVVQREMLHDLQNMYTLLKPLSNALPILMQEFEHFVRKSGMNCMETTINDAAEFVSNIQSLHEKFTRMITAIFNGDNEFVAALDRAIQSVVNHREDAKQPPKISEKLNRYIDSLMRTKKGKSEAEIDTLLSKSIVIFRYIDDKDLFQKFYSKMLSNRLIGSLSFSMDLEETMINKMKEACGYEFTSKLSRMFTDISISQSLTKRFHEEMLKQEIKTDIPIHVMVLQAGAWPLSPPSASSEPSSSAQQQQEVLSDYVPPPVLQNSLKLFEQFYTSSHNGRKLTWLYGNSTAEVQLNYLDRLYQVTMSVYQFSILLLFSNQDAQQISQIAFQCSLSIQSVVRASRSLVDIGILITEAKVDEMTDKSTLRLNTAFTWKRLAFKVMLPLPSKPQEKETEATCNTVQQDRKYYTECAIVRVMKARKVMKHSALVEEVIKQSQPRFIPDVQFIKKNIESLIDKYYLQRTDQNDEYEYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDS9</accession>
    <name>A0A914HDS9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COX assembly mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDS9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16426.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16426.t1"/>
        <property type="gene ID" value="Gr19_v10_g16426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16426.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24247" checksum="C5ABD7B5B9924E0C" modified="2023-02-22" version="1">MYVEQGSSDKGSYQNSSLLRDASSAPFLPLPKFEMSQQPNTSFKIVDTNDKNQLKSLKEGEIVKGNNGKLYRARKTIYPSQTGGPRGVGDPESKLLNQMEEKLLIPERMDKEVHKTECRSEFSAVVQCLRVEGSLLGPQKCRPFLKVYEDCKLMKFQDDDFRKKVTEDYIEERSKFREMGLNQKQRKFYEYLQWKEKQNVGGTYSADSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HDX9</accession>
    <name>A0A914HDX9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein NATD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">28S ribosomal protein S26, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Small ribosomal subunit protein mS26</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NATD1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HDX9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16615.t4">
        <property type="protein sequence ID" value="Gr19_v10_g16615.t4"/>
        <property type="gene ID" value="Gr19_v10_g16615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="Ribosomal_mS26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="343"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="239"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16615.t4"/>
        </source>
    </evidence>
    <sequence length="395" mass="45736" checksum="D57DBE7CE8CEB349" modified="2023-02-22" version="1">MAMLRAEQHQQEAARQERVSLSETSALYMSHEIRHNLGKFLFYIRMGDNSIALLEYKKLPNRVLDFQHTEVPSQHRGKGLAEELVRGAFRYCLDKKLRVYPSCSYVQKFVNDLASEEEKKIVVERMISKSAFCGPSTPFIFCRRCFLNRKLPNPGKPPILPPAKSKMYKVHQYKWQDPSDVAELLWRRHVYNSAILSMRRLFREEVALKKSLAMGLEEIKAAEAVELNEILALNEQRNIKLAEARAEREKVAMAQIEEETLKEIERKLDWENANAEKRTKEVLETIERSKTEYVTRENLEQRVEEALENPQNFDYAIDLNGINIPNPVPTKYVHSVMNSPSIYEQPLDYGPPIDGYTYKSARGRPGHSKVQRNRNSNKPRDGEEQGSEELDSAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEE8</accession>
    <name>A0A914HEE8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cullin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEE8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15859.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15859.t1"/>
        <property type="gene ID" value="Gr19_v10_g15859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="404"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15859.t1"/>
        </source>
    </evidence>
    <sequence length="781" mass="90222" checksum="20A92CB9673124D9" modified="2023-02-22" version="1">MNLRPKAVNFEDVWSKLRETLEAIICLKPIERITWDHNFSDIYFVCVSVPEAQSRRLYMAVKKCLERHAAEIKESLLLLSGDRLLSAYNSEWEKFHKGAICLHNLYGYLNKQLTKEKMDAESQHTFMADTDRDGQCPHLGVGDLAFSIWRNGLIRPLAPQLVSHIIELIGRLRTGVSSSIGIRISDIRGAVLSFVAVNESIQQEQRTQLLCLSTGIPLTEFYEEIFERHFLEASENYYRTLTNETFAHLDCCPYMESVIQKTNEERSLVQRLLHYSTLPKVEQLCSELLVNDQLEKISIMCREVVQREMLHDLQNMYTLLKPLSNALPILMQEFEHFVRKSGMNCMETTINDAAEFVSNIQSLHEKFTRMITAIFNGDNEFVAALDRAIQSVVNHREDAKQPPKISEKLNRYIDSLMRTKKGKSEAEIDTLLSKSIVIFRYIDDKDLFQKFYSKMLSNRLIGSLSFSMDLEETMINKMKEACGYEFTSKLSRMFTDISISQSLTKRFHETIFHLKEMLKQEIKTDIPIHVMVLQAGAWPLSPPSASSEPSSSAQQQQEVLSDYVPPPVLQNSLKLFEQFYTSSHNGRKLTWLYGNSTAEVQLNYLDRLYQVTMSVYQFSILLLFSNQDAQQISQIAFQCSLSIQSVVRASRSLVDIGILITEAKVDEMTDKSTLRLNTAFTWKRLAFKVMLPLPSKPQEKETEATCNTVQQDRKYYTECAIVRVMKARKVMKHSALVEEVIKQSQPRFIPDVQFIKKNIESLIDKYYLQRTDQNDEYEYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEH5</accession>
    <name>A0A914HEH5_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HEH5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15874.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15874.t1"/>
        <property type="gene ID" value="Gr19_v10_g15874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000123">
        <property type="entry name" value="Cyclin-Y-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012399">
        <property type="entry name" value="Cyclin_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028934">
        <property type="entry name" value="Cyclin_CG14939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="175"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15874.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39774" checksum="E9D35E4B188C42A3" modified="2023-02-22" version="1">MGNKNCCVRHTPSISKKKSQENHTPNHIFNGRDSSVNFLPHISEREIPDDTEQDPSTHPSVRPTFVERSRSELKLRDNRRSFYVLDLNNLHAPVTLKKSNSCSTIYMDDSTISQPHLKNTIICVSLAVFYHIINRKHRGKERLMEIFEERLHPITHEPVAAENFTRDPEHRQIYRFIRTLFHAAQLTAECAIITLVYIERLLNYAEIDLCPSNWRRIVLGAIMLASKVWDDQAVWNVDYCQILQDTNVDDMNELERQFLESLEFNINVPSSIYAKYYYDLRTLAIANDIQLPLQPLYKERAARLEALSRNYEDKVALNSQKLVKCMSAERLREHRSPAIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEL9</accession>
    <name>A0A914HEL9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEL9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16809.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16809.t1"/>
        <property type="gene ID" value="Gr19_v10_g16809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="43"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16809.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26917" checksum="D1E90B8FBA20E2C6" modified="2023-02-22" version="1">MSNPGASNENDSQIKRRWLPRELQCEIVRALPFHSSRRMLLVSGPIATNCVESVRKQKQKFENRWDPTACHAGLTLIEPERLMVKFNGNHREVLRYVFAERPIPKNGIFYFEMNILNDKSGAAIGLAPLNNFNGMYAFRSRDCFGRSAAASRWPNQRPTFDAGDVIGCGVNLATRQRIYTRDGERLDTTNLFVPDSADDLFPFVMLSKRGDKIEANFGPNFSFNIAEVINRFYGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEU6</accession>
    <name>A0A914HEU6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEU6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g15967.t1">
        <property type="protein sequence ID" value="Gr19_v10_g15967.t1"/>
        <property type="gene ID" value="Gr19_v10_g15967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF5">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g15967.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22830" checksum="BCBED1E615DE9DD7" modified="2023-02-22" version="1">MPVFKKSIKKRDNDNAPSAVAASTDDFGTQPVKQLDSRLGMDGYRDFYTLKNYWKTVNRRWKESHGLFMYRYLKTCPEAKERYQKLNGLNIDSPECSEPAFETIASNYLKVFDEVITAVEQTPSDASSACQRLSSVGKMHRSKVNGIKFDDFQQLEAPFLYMISEILQDRFNEKAEMLFRKFFQFCLRFILEGFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HEU8</accession>
    <name>A0A914HEU8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HEU8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16864.t2">
        <property type="protein sequence ID" value="Gr19_v10_g16864.t2"/>
        <property type="gene ID" value="Gr19_v10_g16864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16864.t2"/>
        </source>
    </evidence>
    <sequence length="67" mass="7415" checksum="74E75C381C675EF4" modified="2023-02-22" version="1">MGNAADTLCGQNDDIEPNNDKEAMADQQQKEGQTKADQMEFPLKQTANFEQQKINQKALSAAIDQCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HG67</accession>
    <name>A0A914HG67_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HG67"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g16866.t1">
        <property type="protein sequence ID" value="Gr19_v10_g16866.t1"/>
        <property type="gene ID" value="Gr19_v10_g16866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="19"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g16866.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33441" checksum="EF6C05524EDD91F5" modified="2023-02-22" version="1">MDTTNNPTQQEDVVVHPWYPWIVFVQSFKYCANPPNTHIFVQCTGALISENYVITAAYCVRWNLLKLSKCLGKNDTNILGLQFTQPDELFVRAGSSEVNRANRMGVSKISVPELFEFTQPEPRRFDIALIRLKTRLQRQEYGIPPICLSRALNSLEGQMATTVGWELKDYLMPNTLSVHSLSEERVPILARSHCPRMLQLPDDEYNQFNTFVCAGKTNRSVISGIYGNPMQIKRNGRFYLVGLSSSSFIKPHETSDIYANVSSYCGFISAVTRSEVRCLDEEHNDGQDIDPKCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HGI4</accession>
    <name>A0A914HGI4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HGI4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17291.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17291.t1"/>
        <property type="gene ID" value="Gr19_v10_g17291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17291.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33241" checksum="5E337DB18747575D" modified="2023-02-22" version="1">MVSNFALERAIRYLKLALLVVIALYLVQIYKFVATFLANRWSTNIIQIASPIYDIGEKGYSNSLPTHPVLFKLLIERNYFAKTLSKQSKFKYSAVTCFMNNYIIGLLSSHTMCQLPFYPQSNRNSQNVYFIGGEEDRIFRDNFQMLTGSYFNLTVVNNTHLEELVEKHLGLKDLVSEGNKFGKTELIKYDIEKPGQEQLVLSLTTPVEACVIFVALRRHSLERVRNFVWEMNFALYHVMRLQLRIQPYRFTFISFIRHSCLAKYNVQGPYLVEMRPNGRQIMAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HIW6</accession>
    <name>A0A914HIW6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HIW6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17050.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17050.t1"/>
        <property type="gene ID" value="Gr19_v10_g17050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17050.t1"/>
        </source>
    </evidence>
    <sequence length="507" mass="57916" checksum="1D4C90BD031BE387" modified="2023-02-22" version="1">MGLRAREGCLINNHLKTWKAMGPRAREGCLRPPTDKTWEAMGPRAREGCLINNHLKTWEAIGPRAREGCLINNHLKTWEAMGPRAQEGCLINNHLKTWEAMGPRAREGCLRPPTDKTWEAMGPRAREGCLINNHLKTWEAMGPRAREGFFLSAKTFAAPNDVKSKQLLTFSPIVTELAQKIVEECLDEYKKMMAKLTTSNGRQPFNTNWVALHGILSKALSQNTNKNYQMIANSCQMSNAPPVVRSNGTILLLLRPESLFCDYGKSLAFVKRYFEELKETTKLDPEFVKEANEMFKKMNEANKQFLNIENFASDVENALIEIKFQHEFEAVDKIWARKMLTALAGNCKNYILDAGESRANRTNAFQTAVKAIRNVQLQPPNSNRNQTEIDETCAILYTQNPGKNLCMFAKKLAYLTKFNQMFGIPTNSFGCWLWPLNSNRNNAAAAAEECLDCLDIMRHVYEDELRKVTKWLWGKVKRQFLEKFAFDRQARDVENAIKMMFEKGKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJ37</accession>
    <name>A0A914HJ37_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJ37"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17851.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17851.t1"/>
        <property type="gene ID" value="Gr19_v10_g17851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="30"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17851.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39848" checksum="EE46F62B38F241B8" modified="2023-02-22" version="1">MAHLNSASTSPCFEPREELPRLRARIAELENRQTVLMSEVEGIAKMGLTPQNQWDHSACHNELTLSGRPKQLIVQHTGDWKWLSVFAVLPIPKFEFGKFYFEIKVLGTLNERILCIGLGKNKSSFGDVRYYEGAYVYESSGKFWGHEVEGCTRKDGRPYINGTSFPDLDSGDVVGCGVLLGNRQIFYTKNGERLGAGLHEISFRAMETRWRNASFICPSIISPSPSIVDSKAKAAGQVADYLNSALFDGSSAAFWRSPMNSAKYSLILPLVLKYHSATMGTMEVERFFSTATFLLNDLHMTDLFVEDGELFPCVSLFSSHMKIETNFGPFQKSVQLKKVVGVMNTMHGMAPTLIGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HJU7</accession>
    <name>A0A914HJU7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HJU7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2145.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2145.t1"/>
        <property type="gene ID" value="Gr19_v10_g2145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2145.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="42644" checksum="829FB34BB7125F65" modified="2023-02-22" version="1">MDDGCPWSCIVIDLLDVGKYSMVPIKQLNGHHLFRRFVHFLLFRLRCLVHLFRTSHDMETLYYNRIVLPIAHIYGFTGQLLKGADINNRIFSSVYLAGRIPIISALIGELENEFNTFIVEMKLENMVFKMKNDIHQVLLVLSCESAIGLLRKELSAKIKMMTLQLDYKQYLNVYVYERFGHKLKWYSGRIIDKFHQMKSETNAIKRQLKNLYDSVEYAVFEIKNSILHLLDLLCDQAKMELFELHDKLNEIHAEDGDGQTLTIHLILKINKIVDGAVNVYKQLQDGFSCNNMPRETIEFQRQVREQQELAREMQEFELAHNTLPTLNDVKQILRTKFLNPTDVEEIVATEKDIVKRAYEMPQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HK44</accession>
    <name>A0A914HK44_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HK44"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g17355.t1">
        <property type="protein sequence ID" value="Gr19_v10_g17355.t1"/>
        <property type="gene ID" value="Gr19_v10_g17355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g17355.t1"/>
        </source>
    </evidence>
    <sequence length="753" mass="86007" checksum="8FD740FD55B59DC7" modified="2023-02-22" version="1">MEKEHESPPTESRESPSFSLERKCLLSRKMGPFYEKPINPQLLENAGQVYSDAPLQRLWRPDSSTPECSDNERRERHRKRFSVGKRVRSVLFVGALTICLGLLVLWLFLLLTDAPDKIKSTIPPSSPMPSSLSPSSLNKATIPPREAKESYRTTTIKAKGRKAQKHNHPHHHIIHVTAPPTPLEEERMKPTSMMVSTTTPLEEERMKPTSMVVSLAAVYMEVPEEWEKRREDGKERSQVVVAQIERVGGTGTARVTTETTPTTIPMMTTTSTIATTEPTTTMPKSVESTTAKTASATERETKESGLDVDEEEDLFWMRGDNGRHADRRPTDSVRVMPSPNVSLVSLSAPAMPPSSKAQSIPDMYDEKRPTIQFGPMNAMEVAGKTRERELEKEKQVREELNEIIASVERDGVSPVEIPFDPVEWPSIPVPEPVWRRPPPDETAALIPPPPQKTPSAPAIKQIDAHMTYEQPMHVKAKLDRKRREAPVMVTALLDIGRGKWQRFTRHFDQYLGYLANIVLRLQNRLIIYCNSSVTSYLHSLGDRIDWERIQIVEMSLQELPYYKYRDEIEEIMRWEQEHWHNDWDKQMQSHPETLYPDYDILVNSKPYFLVNATKISRFSKPPIGGQQFFVWLDAGYGHGSISEIPRGVWSPMLKAGKITVVQLTSRMERVERYSLDKVYRKQKSVVSGGFLAGSPEAINRFHTFFHLSFMEMLDARMVDDDQTTLLVTIQKFRSTFNIIFGGWFDAFKLLPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HKM3</accession>
    <name>A0A914HKM3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Receptor ligand binding region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HKM3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2006.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2006.t1"/>
        <property type="gene ID" value="Gr19_v10_g2006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037133940" evidence="6">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="248"/>
        </location>
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            <begin position="31"/>
            <end position="54"/>
        </location>
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        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004370"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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</entry>
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            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
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        <property type="gene ID" value="Gr19_v10_g2104"/>
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            <begin position="105"/>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2104.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12260" checksum="C9E9DB9C0F4D85C8" modified="2023-02-22" version="1">MQILATKPKNAKSTPGKDKKSPATPKTIKAAEPKPESSVPGPSSAPVVAERDVGEASVNDFDTVDDFGAEDNEFDEDNDLAEEEEPLNDDAFDGTADDFSGMGLDQDKPKSNMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HLP5</accession>
    <name>A0A914HLP5_GLORO</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
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            <authorList>
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        <property type="gene ID" value="Gr19_v10_g2285"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="ATP-synt_Fo_b"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2285.t1"/>
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    </evidence>
    <sequence length="382" mass="44239" checksum="6060C0FA441D3735" modified="2023-02-22" version="1">MAILLHPALMSASNRLAAMNSFGTFLNRWQRTSLFRVDGTVLTQFRMIRRGGGDRQHSVEDYEAVFSREAKEEAEQQTRRAKEESEQQTRRAKEEATRRAKEEATRRANEEATRRANEEATRRAKEEAEQLLLEIRAELRSFSWQSMFTYNIKEADANVEEQLKTRIRDFNKHLYLNKRLSAYELEPVANHLVHYNYAMRVFYAGIGLVIVSMLIIYRLLSRGGDGIMPEHRAIIDQQLAIDFDEFVQDYLLVGGEVKIVYVYPDKSIAIAVLHPGAALIQRQPFNDSAVLIRLDPQTVGGTNFLRTFEDVQQQIGTYLCNHVPAAIPMPSLMPKFLLLLGWAILWALYFKHLRAMRRRPIFIVKRRDGTRPLIQSDRLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPT7</accession>
    <name>A0A914HPT7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
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    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
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        <property type="gene ID" value="Gr19_v10_g3526"/>
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        <property type="entry name" value="CE4"/>
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    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
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        <property type="entry name" value="EB_dom"/>
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    </dbReference>
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        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EB"/>
        <property type="match status" value="10"/>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="22"/>
    </dbReference>
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        <property type="entry name" value="WR1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037318435" evidence="2">
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            <begin position="29"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
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    </feature>
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    </feature>
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    </feature>
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            <begin position="521"/>
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        <location>
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            <end position="938"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3526.t2"/>
        </source>
    </evidence>
    <sequence length="1828" mass="192390" checksum="1B6EA7738A4518CB" modified="2023-02-22" version="1">MPFFAIAAAHINVLYLLISLHQPYSVRSEPPLRSANVPSSISSPSLSSSANDVLLEPFGPHQQQHKQFPQLIGWTDRPGEQIGDQCDPTMRPACTVPNSECVGGVCECLAMYYPDSLFRCAPIDTEGSLGRLCRRGMDCRGNGEFCNKASGKCDCVPSFAAVDWRCLPGILPGDYGCIDWRQCAVSYPEATCSGEGKCHCPPGMHAQRGTCVPGEIGPQHDQPLPGRAPPPSQIDPGGDAPPIVVGIAPDGVCSSDSSCAGYPLAFCDGVCKCREGALNAGSACIAALENGATAGSCPSGQIYVQEIGTCLSASNPGAPCQYSQQCSAEEPGAFCLQLTCECVYGMQVSQDGHTCTFSDRNCTRRGEIWIAEIGQCRQAILPGAGSCSHSMQCSAVVKGAQCLLEQCVCPQELPVATDGTCGSQCPQGQVYSGVTGSCLPAVQPGGECLYSSQCHAVFPGMLCSLSRCRCPNNQVFSGTRCMPTCPQSFIRNQFGVCQPGCRANQIEYQGQCIDIVGPGQPCVVNRQCAGGSQCVNDQCTCPTSMINNSGVCVPMRAAPLGSCVRGERCIGGSTCMDGTCVCPTGTSSLNDVCVTKMTVPPNSACSPAVDCGGGSKCEQGMCSCVPPLLAINGTCQYPPTVPPNGPCPTGRERCLGGATCQQGQCKCPLGTVPDGVRCAVVTQVGAGQPCSATNVCTNFAVCVQGVCTCPSPFVAQNGQCLRPETVLAGASCAMGEACPPNAYCSVDRICSCIAPTVNVGGVCRNVQTVLPGDPCPSGEVCLGGSNCFAGLCQCPSGMTIHQDQCVPMPSGTLGQCTDNAQCTGGAYCDMARHLCVCPAGQIAVGGICTNIYGSAGGGGAPSGGQSASIVGPLPPARRRHFSTQRRRSHIWRRKKRSNNFIENDVSRQQTKNEWENEKSLPVEFAGTVDEPEPAEEEGTVNTLHIGTGPDMNRHSTTTSAPKINNFVAPNVVQLADVNGSAVRRELGLECAEQGAPCANGNAHCMDGICRCLDGFVQAGMAICVQKNKIANPIVEPGQPCGPRDFCDGGATCIQRKCNCPQGFMPQQRNCIQMSSKSGVQTVGLGAKRLVKKSPGLNCRHNPDVCTGGSYCFNGYCVCPEGYEERNGECIMPKIYVEPGASCERPPGIIAQVECLGNSVCANGYCVCPNGEPIQNKMCVTVNSIASPGEPCIANLTKCTGNSVCNNGFCTCPYQQVSLNGQCATVTIATQLPSQTCTPATICLGNSICQGGRCQCLPNTVLSRTGTFCQPISVILQPLSTPPIGIPGYACAVGEPHQCSGNSRCVQGICTCEAGHVPFQSVCVPSFPMYVPSWTGSGMAPPPPPAQPPAWPGMYPSNYTLIMATAKPPFPSGVIPLRPGESCDPRCEYTGTCDKACSGSSICADGVCTCPQGEYAQDGQCVPYVVTVQPPPATMAPPAAPVAPPAPVVPLKQKRRARDAAGRPSEGCDFSSAVCVGGSSCILGICQCPPGYSPSRDKESCVNGLLLDPLHSPPQHPSNRDKKDQEQQQMLLLGQHCVQSTDCIPGAQCLFEVCACPPRTVADDQRRQCVPEDGDDQAQESVPKMLLLRSSSSPLVTQKVKSRPGWPCQVDATNKCTMGAQCIELVDREKLDYNGTNQINEQTSDQYLGFFCVCIDPTGGQRIVTNSTGHCTPRLLSDTIDKSLPGSPCKFDECEDNSTVCRGGYCIYLADSWAKGLNRGKIVEQRSKKMTMIPVEELQSMNNNNNSSRSNNKLEAYKEERWPPIFGDEKSGRAAADFEKLVGDPCTVHKECEPPALCLRNQCSCPPGTFLALSSDRKCTFSPATDGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPU3</accession>
    <name>A0A914HPU3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPU3"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2783.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2783.t1"/>
        <property type="gene ID" value="Gr19_v10_g2783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2783.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="16350" checksum="811EE6B4AC35373E" modified="2023-02-22" version="1">MVKVSSSALPGGGGHSPRGPPPPASPGGWAGPGEQQNIGATQQHNVGSSSSPAVSDGAFAIPSPNARFVRSYGGAPQPFTGAVGRAVGGQQQHFSSANAGGFPGAGGFGFPGYKGGGQFAAGGSGGFPRGDSPTPGGAIGASFDYRQPFGRLGTVQSYGGWAKSKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HPZ9</accession>
    <name>A0A914HPZ9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein regulator of cytokinesis 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HPZ9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2821.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2821.t1"/>
        <property type="gene ID" value="Gr19_v10_g2821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2821.t1"/>
        </source>
    </evidence>
    <sequence length="531" mass="60522" checksum="F66420A2780A7CA9" modified="2023-02-22" version="1">MSTTNNATSIFASPLSSTPDSFPQRQRIGVEDSAENLARTIRSAFRGLNELWNRVHMDMPTREHRAQQASEYVHNLLGDIRSSEEEMIQNVVADLEARREAVSNLRKFLALPSFEESLYPPDSIALLKALDTEMNRLVVKREEIVGRQITLYEKYEALCVQTGTMAHSVEGVHDRILTEAELGKLNDEIKTVRSLFNKRLEKALQLQAESKRIYESIQLPANNSIGEDDLHCLRIDLHNHSVVLSSEVLKKMGAINQRLKDQYDAWIEQVAFRYDELIVKLDDLATKCFRPPLSTEYPTKPNLKLLNESQLQSLEEEVRARQEVYERAKPVFDKLNEWMASWKQKLDTERRVCRASFYKNRAGSLNTKLKQRKMVEQKVPKLLDELRELCDEYVKQFSVDDIVVDGKRADQYAKSVMQGYQQDKEVQKAQKQFSTPSRPTTPGRSAPSSASRRNVFGCATMGAGRTAVRALKLHGDMQQQPLQATPSHKIGEGMRGTRKRSFSCSQLSAIFPLVSPMMEPRTSSPKPDECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ34</accession>
    <name>A0A914HQ34_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ34"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g2848.t1">
        <property type="protein sequence ID" value="Gr19_v10_g2848.t1"/>
        <property type="gene ID" value="Gr19_v10_g2848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g2848.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10765" checksum="5CFE3576FD175DB9" modified="2023-02-22" version="1">MPSDSLAFRVIGDGMRPYGLWVVTLTKLLLIYVITPPVEGKGNMNFSNGKEWRRTEGREDGGGRSVIRQKGEIPPPPPFLPIYPVIRSEKSQLGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ52</accession>
    <name>A0A914HQ52_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HQ52"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g362.t1">
        <property type="protein sequence ID" value="Gr19_v10_g362.t1"/>
        <property type="gene ID" value="Gr19_v10_g362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g362.t1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44425" checksum="109F32FD4D84E256" modified="2023-02-22" version="1">MLAISETIQKLATPTHRNENENASNGKVRQKLRRPTPFVDAFCDYTSISGFRFLHSRYSFWFRSMSGLVLFGSIGMFLYHSSIFIRRFNDKRNSIQLFTTKVHFVRTPFIILCPLRQVKSIFYYDEDGPADFIHIVSRYYDTSNVLPGKFPIIDGVSVRNSTERALRVARDFFDLASRHFSDVDAGAAEVLNGPKLFVDDPIFRKLFPKSSLLLSFEKVLTMARNWHSVYANFDNFREWVCQSEDPCYAIVNETDPTMSNSVSVLNFARCRAKAVVVQLEQVLQKIDGFHEYVRKAQPPVGDVILFCRWLDGGKCTKEYVRSELGIDCVKLGGINHSMASYATLRNNIDVVIDLSAFDNKLATWKESELQILLCPTNESTVCTTVDGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HQ55</accession>
    <name>A0A914HQ55_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HQ55"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3417.t2">
        <property type="protein sequence ID" value="Gr19_v10_g3417.t2"/>
        <property type="gene ID" value="Gr19_v10_g3417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3417.t2"/>
        </source>
    </evidence>
    <sequence length="318" mass="36712" checksum="0B820C43FFAA2F4F" modified="2023-02-22" version="1">MGRSCRAYSVGEVIDHGCFVNRRENAEEITAPPLFHQILVIMAKRENWGFPVCYCLLSCKTATTYDRTFQMMKAVWPNFAPEIVTVDFEEALINAIRSVFGHVQIDGCFFLLVHNFHRRLNGFDDEYGNNLLQTYRSDPIFAESARMITSLAIDLTAAIVALEQVLPDSLEPVFMWFMTYYTGRPLLNGGRTQPQFLPDLWNLYTRTLDGRDKTKNHAESSHRRLKRAFSCTHPSIWHFINVLRTEQKSRDADFARFPFTCVSVSDLPFLAYIPPEEVRRMALMKTCSTNFVSRTCRFEVAGHSPPPYNWLSVRQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HR54</accession>
    <name>A0A914HR54_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HR54"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3152.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3152.t1"/>
        <property type="gene ID" value="Gr19_v10_g3152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3152.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21517" checksum="C540AA9AD0E570A9" modified="2023-02-22" version="1">MSYCSNPFVKTKELGRLSATKNTKSLFYALELARCYQLIDSNAARKRFDRLLNAEGKTEELAMGLIERAGIGGKSYGTAHLNLVQKYWDQEYPEMFRIVAFNMKSGLNPIFKGENVRKYEVCVILDNGHWDAHKKIRPLPRYRIVVYDLETTVVNGEHTPNLVSAARTCSVCVGADKECEICRSGPKMIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRI4</accession>
    <name>A0A914HRI4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRI4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3268.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3268.t1"/>
        <property type="gene ID" value="Gr19_v10_g3268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3268.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18752" checksum="4254857914859A1A" modified="2023-02-22" version="1">MLAYANAIQWEDVLGNPKRTSPGTPVEVPAHLAELTVRHSMKFQKRPGIHMSTSRFDKAAFVRSGPERNGIRCPKQSAKRRIRAHVPMQLGSPKLLIQPYYREYGFRIQLEKCHFLQKELIGPHCICEWYPTRSGTISGNSRHACAHGSQHASLILVRNQIDQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HRQ6</accession>
    <name>A0A914HRQ6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HRQ6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3109.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3109.t1"/>
        <property type="gene ID" value="Gr19_v10_g3109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="343"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3109.t1"/>
        </source>
    </evidence>
    <sequence length="543" mass="62316" checksum="404008F5388AEC69" modified="2023-02-22" version="1">MSISPKSTTGEGDITADQDNLGPSEELRLLRARIAELEHQQSINLPTSSASFDLVGQNKNDVADNLHGQINCNFELELKDMKQFKEKLEDVKQLNEEFRRNLFFPFWVDHLLLSSTELRAKEELHQLNEESKNTKESFEKKLEEQMEALQTKMEKYQHKQQQTIDQLTQKLKVSIDQLSLKHQEHEKLLNAHKNLMEEKIGWLNEDQQKLVSIDQFLLMQSDQKELRAGHEELSTAHEKLMEEMKEQREMDALKQQTDQKETNDKIDSLNKDQEQLGSIDQLSLKHQEHEELLNAHTNLLNEMKEQREKDVAELEQQKVSNANKFAEIEQKNDKLEKDQKEQQLNIVRLQNTVATLSEIVLINRWDSTACHKDLALSEPDRLVVQHNGEDYWREGSVRAEKLLPGNPYGISYFEVKILEQVGGPISIGLATKRMPLNSLVGLHEGTYGYEDGGFFWGHAVDGCYHWANGRPFIGGKPSFFVGDVIGCGVNLATRQIIYTKNGERLDTANLFVDSPADLFPCVSLGMPGDKIEANFGPDFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HT15</accession>
    <name>A0A914HT15_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HT15"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3495.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3495.t1"/>
        <property type="gene ID" value="Gr19_v10_g3495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3495.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27608" checksum="C2349CF623488438" modified="2023-02-22" version="1">MSAARFFARRRYVRGALFCAARLCALRAFLRGAAMSAARFFARRRYVRGALFCAARLCALRAFLRGAAMSAARLCARRTFLRGALFCAARICALRAFLRGAAMSAARFFARRGYVRGAVFCAAHFFCAARLCARRVFLRGAACALRAFCAARFFALRAFLRGAAMSAARFFARRIFLRGAAMCAARFFARRGMCAARFFARRGYVSGAVFCVARFFARRIFLCGAAMCAARFFALRGFVRGALFCAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HTK8</accession>
    <name>A0A914HTK8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HTK8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4096.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4096.t1"/>
        <property type="gene ID" value="Gr19_v10_g4096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="166"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4096.t1"/>
        </source>
    </evidence>
    <sequence length="369" mass="43277" checksum="4ABB9C271F390BA3" modified="2023-02-22" version="1">MVEQIVEYRDDINFAVKLDVLETGKVVISPKKKIGHLLWSIKIMKYNSSKHSRRRFIRYFVQFERQADGNPAEFKLDAYLDSCAITKPDRAPEHDYQYTWSCEPLRFESMKCDELTWHSEWRWMNLDALRSAENEFLDDQGRIHLWARVDIFELSNYGRADKPDLLTVNGRTFKVNKYILAGFSPFFRTFFFKDGFKEFLTQNFEIRDPEVDADMFGRMLDIIMTQDQYDPDDETVEGLLELADKYDIAFVKEFRMAETYGLVALKGQTVRRMDPQEFCSNFLDNVNEFAKLSDRSTTFPCHNCKKRRRLLSPDLRYFTTRPLSRSRTVSSTRTASIRSMSRSSSYDGHASDDDNSSIYHPPTEASFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HU57</accession>
    <name>A0A914HU57_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HU57"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4011.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4011.t1"/>
        <property type="gene ID" value="Gr19_v10_g4011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036908162" evidence="2">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4011.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22625" checksum="E197587367C5BE86" modified="2023-02-22" version="1">MEFWILILVSFFVTNSLDKSESLHLEETPLKIIDEIFGEGWWDNEKDEEWNKLTLEHNFHHQIDRQNTQIGEIESNSIDQFGQIEPNSTDQNPTLTESDHSDNAKNGEEENEISSNKKRQIVDKFHAIKDEFKQKGKYSAKERTQIEDKIDETVAKELGLSDTTIYNWKSELGQTKPNKHSDSEQKELLMKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUG4</accession>
    <name>A0A914HUG4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chloroplast protein-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="Gr19_v10_g3875.t3">
        <property type="protein sequence ID" value="Gr19_v10_g3875.t3"/>
        <property type="gene ID" value="Gr19_v10_g3875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612:SF0">
        <property type="entry name" value="CHLOROPLAST PROTEIN-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SecA family profile" evidence="6">
        <location>
            <begin position="675"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="780"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1676"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2014"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2244"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1676"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2028"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2081"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2132"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2150"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2187"/>
            <end position="2214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3875.t3"/>
        </source>
    </evidence>
    <sequence length="2818" mass="316229" checksum="FAE6A5257B6C011C" modified="2023-02-22" version="1">MRPLWGPQSYSSSHMQHFLIPSGHWFFVLLLNLLIPIQIHRKCVKVQQHTILSPRARARQRLALQEQQRRKRDAEEREAVVARGIEAVQEVQKTETFLDLDFQQLGNTLKQKVALSILKARPNASGGPTQFSAAAFMPHGNVPSKMDNGDGNRSFSSCRGKGNDDDDQTVAERTDQQISDVCAQLRAHLEELLQLRQHCIDVRTPTEKANLILKQIPDPEQDIRINDEISDDEEDVKECAKVETTENSDYEDESSADEEDYNPRVSRCRRALRAIKLPIILAICAKTEDAFLDNSDKVQSIIAKIEALRVPGAGAPMEDAKRRSRQVQELLKDFGRISNFVPLLANEEQTMKDLFETAQNTAADHSDGFDGNQKQLFGEEMQNAKKAYDALLKHNLDKLKQRFLENCVKTMKELPTHKYIPEERELLDNFLANIYNALAIQKKLRLEAFEGEERQRKEQHRRTWRCSSTAAPKPPKWGEEYACDVIYGTMQDYPSQEAYDEFFGKDVRGGRRIDAIINDEGDFSKIYENLKQKGGQKDDDDQHESKNRADEITSRQHILTMIKEFNDRWIRQLEEAENCPMTSSKLELLNEFKEAIKRAQMIYENFLQKGGQKDDDQQLSFAELVEKIMEDGGGFSAVLKHMGESRLKAVNGNLRKWLGDSYNKFKQECERFGDFVAEEIKEWWAEHKSSPEGESRLKAVNGNLRKWLGDSYNKFKQECERFGDFVAEEIKEWWAEHKSSPEGTTFEQKLALIAKGVQVISGFKPRNTQLLAVMLRRFVAAECPEMHGLMLQVATGEGKSWIVAMLAAMLHLTNHSNKRGDQQIKDDEPMSGQGMLVGVITSNHHLAKKDAEEMANFFDLFGLTVSHIVLEYSDEESLREAYACDVIYGTMQDYQSQEAYDEFFGKDVRGGRRIDAIINDEGDFSKNDDVTQERELRLATNSPGMESLNEILMFVALARDLILREMKNNGTLTEKDGNATLTAEQVKEVKANMIKFIDQFVEHAEETNNKEKMPPNVRQRRHRRQIPVTARGTNANEKEEEAEENDLRKELAEMAPKIPKHLLDFVKLEIEGWCSSALQALGLNDKVQYIMETENNNGTTNNNGTTNINGTTTNNGLPSAMTPMRIIPVDNMNSGIIESQSQWDKGLQQIVQIDQQTEITPLSLQSAYKNNVGFLCPHTNMTSITGTAGSNNERDFVGNIFKLMTINVPRFKDRQYTKDADDKLCENDAEWTESIVEKALEYTDKRAVLITTGSIEDANTIKDALAARIGQSKRRIRTFIKGRTDEESESLKENMCQGDILIGTMLIARGVDMNPADDVLRNKGLAHITAFPPRNNRVEEQVAGRVARKGQPGSGCLIIRKSDIKRLISDGGGCQNEEWSDRDWENWRDKREALVADQLTSFLQNRIPILSFRDELYKRMCDKMGEVRSICEEEEDYCQYAAVQIQELWSFWINRFDHEIAALIEEGKKAGKTVTDVLDGPTKDGFFRRFDEFIESKIGQLKEFVADPSKSELLENPAYLMKTAHLMLNSEHPEIAREMIKKVDPNDPEFAYIRLYYEAKAHVELGHKLFLRHNKRRPKNRELHEKALKCLEEAVKIVDNKMASINGVLSVLNIKPSSRLSKQFHRDIEALNIFRQQCLTSFNTIVRIDQQKVGVAKIKDCVEIDDAALKYKKEMKEAKKAEKQQKSAATEPPRTANPSGPDDPPPDEPAAAEDGNGDDDISIPKDELEAMKDEGLSHFYNLDIAMPIPSMWTIGLLFFAGVLQIGFGLMLAFCSSGAATQWGWSLINGGWDDVLTSLTMAFDRLKGKESPAFSWAKWFAKKVVHYGKVVLGIFKQSLTAMLPEDNKFCKFLEKNPNFAQNIQMGAGLVMDSGLDIKEYYKSSKTLPYSKGLTRSLAQKVLKREVARKLVKRSVAVGCQMGQRVVDKKFRESCSKKRAKKGDNGGNFWSHLFEEAVSAVITSDLIPNATVNLADKAFTHAMKYDKMQEKFDECVFLEDREESGMTATQARECAEQIKKKNGGKWPSGTKREEKGDRGEGTKGSKSKKEGEEAGGSKSKKEGEEAGGSKSKKEGEEAGGSKSKKEGEEAKGSKSKEEGEGAKGSKSKKEGEEAGGSKSKKEGEEAGGSKSKEEEAEESKEEGEEAQHNGVKKFENKGKRKEELDKAKMQQRAREMLAKGAKKVGNGAKGERNGAKEEGEGAKKVGKESKAKRVKEAQQACNKLILPTSSERNELEKALKKLEDEAEEIEKGRANAEQSSNAETDGSAPLGKLWIIPPNSLPSIVGRPLHLRNYNNLPFQNDEAIQFVTNAPQSSKAQSVGSPTNVAKSSAVSSESAPLGARLIKCTRDGGSGHQGTSASDDQHGDVEQATINYWPFFLPSNAADTLHLRNYNNLPFQNRRPCTDPNYKPTISSAQQQLVKRGKLKVVLQRVTEEEVVAAELSHREQHRFNHRQRAHYAVVKSVKNGLRVINALGVLNDLGTVLQVCIQQGGEAALRKGMEIVVGRVGQTAAVGLVSSAAVATGVPFGLAAVCQIAMGFSAGKVIEVALNANEDRQLTGTTDEESESLKENMCQGDILIGTMLIARGVDMNPADDVLDKGGLAQITAFPPRNNRVEEQVAGRVARKGQPGSGCLIIRKSDIKRLISDGGGCQNEEWSDKDWENWRDKREALVADQLTSFLQNRIPILSFRDELYKRMCDKMGVGRSICEEEEDYCQYAAVQIQELWSFWINRFDHEIAALIEEGKKAGKTVTDILDKPTKDGFFRRFDVFIESKIGKLKEFVANPSKSELLEKPGIFNEDGAASKLSLATVPNKNSPNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUQ3</accession>
    <name>A0A914HUQ3_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g4351.t4">
        <property type="protein sequence ID" value="Gr19_v10_g4351.t4"/>
        <property type="gene ID" value="Gr19_v10_g4351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="4">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="4">
        <location>
            <begin position="211"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="730"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="891"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1388"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4351.t4"/>
        </source>
    </evidence>
    <sequence length="1493" mass="167362" checksum="22859615794683E4" modified="2023-02-22" version="1">MPSLPQTTRNGHSEDDWESFHQPKSHLLRMNARRASAPLRVPRVNLLGDHFDQQQGVRVPVSKARFRTMDALLDQLNESIHLPFGVRRLHTPFGMSPVSSLDDLKPYGKYVVASGARNVRGVDLEAMERRKRRREEAQRRWNFQQSSLGASHSSIQLQQIDQPPETAGNTADQKTKNQHRPRAPTLNNERSSNATKPQLQKMAPFVPITFRQVFFVLNGHPHRVYRALINPNRKGQLDQLLEEVSHGLQAAIFRMYSFDGDRILDIEQLLQLKDMRAVAVPRHEQLLLNGLSSYDNIVRPVRPVELGTDAFATLPPIPRAPKKTSRSSKSSSGASSSNIKDPTEFDQMKKRKKFQNEAEDGVPANCSGIAAVAATAGVIVRRRVRKAAEEVQIEAKDHRSTTGSSSHGQTQANATANSRADSDSGRPRTELDNELNAQKDEDRIKVEEAEEDEDEDEEEDDYPEEPEQLRSLRETEQERSRKRQRNKRKKVMKIDEEEAEAEEDDDAVFDHDGTGMETDHKSEKEDEEQSLEGMGQAVEDVQPVELTHRLEEADIDQKNETVDDQNGGVTVRINRTSSIQQKLGVYTDELERILYGEAAVKIQSAWRGYSTRKELQNNGLFRQKPRMMVNGGTVLHRHESKKDMYKTNDRHLAVIGPNPKSPIVPGTRTSRSSLQPYDNSTEELDSSSEREEVIHGTEFLTERKNETLNWDTNEPDPARVEQRKDPRGDAPYTVTVITGNRWAADTEANLYINMHGSNMDSEKLWLKQEFTDWLHSSAKGQRFRQNQSDSFAFRLPSRLGIINRITVGHERRGYGAGVFIDRILVTEDEVGGDGDEPMDDEHNANDCRQFLFLCNRWFDSGQVDGRLERSVRLSAFYMISSIPVDGRVTRGRWEFVLHGGTNDGRGGTTAQLAITGFGTDGQATTGGLYDTRMATAPSEALMQLDFGDIGELLKIRLEIDGAGSSPDYFLNFVEFKDLDTDERFVVMCGKWLRWRSAKKGDQPFRELLAFHIGVEPLPLITYDGKIRAFRSALSCFSAEQLCVELYGDLGDTGHVLVRVDAIGGEASVPKDAEKAEENDNNGRAAERTVAVDVPFKLEAVSVGRVSGVRVHFEPNAMGEQIFEGLITLQNIFQKQNVWPLSANSSFVLSQIRLHESTHTPYRYVLNRSHLRERVADQQQQTTTSLAKELLTTEMEGISTRLSKRKSQAKSVPSRWLLQMSVAEGSTILPEVMLCGEKQSITMTPVDNSLTDGILSFQLDNSTDFDDPFIKIRILSDGKTFLLAGTDQKQPENAEAEAGGSGELPFTYVDKVRMCDTANGDELRFPAADCMLLRHSVFELPVMWPDRPPIPILIYSVRVATGGSVGAEPSNPELIVLLNLFGELGDVGRRTLNPGDQQQQQQQSTAAGAGVSLFTPKTSSSFEFEATSIGDIRSAQLEVLTVPENTPFLWECAEIVVTDFRGRSAPFYAFKFASPFTDQCSVQRADVLPFTDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HUS1</accession>
    <name>A0A914HUS1_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HUS1"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g3960.t1">
        <property type="protein sequence ID" value="Gr19_v10_g3960.t1"/>
        <property type="gene ID" value="Gr19_v10_g3960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037663455" evidence="2">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g3960.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32466" checksum="C19F4B15BF4AC24A" modified="2023-02-22" version="1">MEEFWISILVLFFATNLIDKAEFVQLEELENLQLQTFDEIFGEGWWDNDKADEWDKLSLEQNVLHQIDRQNTQTGQIEPNSTDKLGQIELNSTDQNPPLTDSDQLGQIEPNSADQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQNPPLTDSDQLGQIEPNSADQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTDQNPPLTDSDQLGQIKPNSTDQLGQIEPNSTDQLGQIEPNSTDQLGQIEPNSTYQLGQIEPNSTNQLGQIEPNSTDQLGQIEPNSTDQLGQIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWL0</accession>
    <name>A0A914HWL0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HWL0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g4441.t1">
        <property type="protein sequence ID" value="Gr19_v10_g4441.t1"/>
        <property type="gene ID" value="Gr19_v10_g4441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g4441.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8180" checksum="C12442F134433F7D" modified="2023-02-22" version="1">MSTALGDDMSGPPLLGDEDTPDEEVEDDVVLPPASAVPVLLGYGHGHGHCLRLSLVLYWLPSVLRLQRGRPADAGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HWT5</accession>
    <name>A0A914HWT5_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HWT5"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g538.t1">
        <property type="protein sequence ID" value="Gr19_v10_g538.t1"/>
        <property type="gene ID" value="Gr19_v10_g538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000002">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g538.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9603" checksum="A9B282CEC7191837" modified="2023-02-22" version="1">MAKRKSKRKAPTKAKTIEALETQFNCPFCNHERVCEVKMDRERNVGFIQCRVCMEDFQTNITALSEPIDVYSDWIDACEAANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HYR0</accession>
    <name>A0A914HYR0_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HYR0"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5898.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5898.t2"/>
        <property type="gene ID" value="Gr19_v10_g5898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="734"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="522"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="766"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="602"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5898.t2"/>
        </source>
    </evidence>
    <sequence length="808" mass="86940" checksum="B1A78790297F6AFB" modified="2023-02-22" version="1">MISELLTKNADDGNGTGENGTSETSSSAESSNMFDKSKSNADCAKVSGLSSTRRASFSEAKIGDGQGRKRSNEPIKRKNQEKQRKSAGDEVIEQRMAALAKENDALKCQLEEQIRLNSVIVANPTLASLSTTINNSNLPRIMFAGGSEEQSSSSLGNIMPNFAASFGSGESKFCTLQKSERSAFSVIRSGNPTQPPLLQSAQRSDQTELNQAMSSNAFVQPQQNKLAAQLAPFSLFPHVQFPPPARTALTVSTVCQPTVSDNHQHTVVEGRQHKDDVNSPIVETGKQQQHQRQLKKQLIPVHPNRSFSNVAGFGTLADTSSDDCLPFNFKDNLRPALSTMATDVQNVNDESPLDFSKSGQQQHKTAATANLNLALPDSVVGELFIKADCQTQQKKQPPPSSNCSTSAASDRWTPVIQQHKHGPTQLQQITTASYNAKQLTNPRKTVLEVAEASSSSSDVLLHLHPQSSNFTPSPHPSLPNFSSSILQLLMLRGRLGLDENGNYGLSPEQLINQPTFNEPITQLATASSSSSSEQQQKLDGNTAPSSSSMLGTLLSIPPNKRRTSPTVPASRTEFCSGLALTSIKKCDESEHIAKESEHSKSMHSSSSLTSNNDKHSSNLNSDSEQSSSGGQHSPNSSHTSHSHTSDSPPSTLPGAGSTVTTVCGSDRTRRGSSSPNSGCSGDDSSLLLADKSGNGGEAGDEMGGRPTNSRSSPPAATTTSLTPMRLKMRNNDELERYMDRRRRNNEAAKRCRANRRAVFEYRSRKAQLLEAENGELRQEMVKLNAELEQLKALIAAKAAAARLSMSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZ75</accession>
    <name>A0A914HZ75_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914HZ75"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6033.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6033.t1"/>
        <property type="gene ID" value="Gr19_v10_g6033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6033.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36011" checksum="AD911D51796DED4C" modified="2023-02-22" version="1">MTNRSADNVVFVQCILPHREYLFSKFSPKITHEGKKRRWLYIRDQLVASGMAHFVGKDDSYMRQKWADMKRRTIEKLSRMGQNSRANLSEVDALIFRIIGGKEAIDQRVVTPENSGLMESTNLNGVHYETTADNDNERHLLLPDQQQQNLTQNSLNLTAATKNEPNITVCTLPLQQQQQATAQQIVPTSQQATAQQIVPTSSASVPMFHPTVIHNGISLTTTLRRKRKRMKKRGDRMPKICGMNCQNEKIPDQQQQMESDDLEGQVKRAKLAYYKSQIDLNYSLKSESVLRKRLLTLQIEQIQQEIEGDDDDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914HZD7</accession>
    <name>A0A914HZD7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914HZD7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5431.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5431.t1"/>
        <property type="gene ID" value="Gr19_v10_g5431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037988636" evidence="1">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5431.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8890" checksum="21A0BFBBC57D2F3A" modified="2023-02-22" version="1">MKQIAVKCFILFGVIFAVASLKLDEQIELPPFCDGPNKDNSKVVVCCKAVKAFERAEQSSYAPPELKECEQCGKELCPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I068</accession>
    <name>A0A914I068_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I068"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g5685.t1">
        <property type="protein sequence ID" value="Gr19_v10_g5685.t1"/>
        <property type="gene ID" value="Gr19_v10_g5685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF1">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037825660" evidence="1">
        <location>
            <begin position="42"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="337"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5685.t1"/>
        </source>
    </evidence>
    <sequence length="424" mass="46839" checksum="D30AF96A20F06C91" modified="2023-02-22" version="1">MFPVRIHRGNRVNKRSTDFELFHLLFLIFIFQLIQPPAVKGAFDVPCTQKLIGNKCLFDEDCYGTNTVCRDGRCTCPTNFEEFDLDETKTVCRLAPSKIGDSCQRDCKPPLLCRDGKCECWGGSVVNGICTVPCPPGQQLYGVECTRVASWGQNCEQDTHCVDPFNACIGGKCQCAPGTHRDQAKGRCFAVCPDGIAPLQTCRRLFINDVDMLDNAATTDSCPIGYRCVTYGSPYIGHCCKVRCPYGEPDLSQSCDAGAQEEQKCRPLTHFCMTLSEPGWKTSICCPKPCRDPLPVYHNGQCLSIAHRDDPCQSDLQCEGGVTMACVLGQCDCERRCTLEEVPVIDRCLKKVELGERCVSSKQCGDAAAECRFGICQCLCTFKQANILGGPPRCTNPDDPLGFSNILTRVEQIFQNRQKGFNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I1Z7</accession>
    <name>A0A914I1Z7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminotransferase class I/classII domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I1Z7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6131.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6131.t1"/>
        <property type="gene ID" value="Gr19_v10_g6131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="64"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6131.t1"/>
        </source>
    </evidence>
    <sequence length="779" mass="88336" checksum="E9E3BD1D8A194B36" modified="2023-02-22" version="1">MVAERAQRGLKLPSSSVQNKLHQEDPYHQENNTQGYIKLSSADNILSQDLITDKFRSIDWSKFSMEQLFVYPRGGGELRTLSSVARFINRFCRSVDSEVPPVKEEELVIVPGVTSGADLLSQILFDPGDFVLVPSPFYYRFVNDFGERGLVHVGCVPALSEDGTCTELRAERFDEVYQGIMQQQQQGKVRAIMLVNPQNPEGGYFSLEEIRPVVRWALSRNLFVLLDEIYDLSIYDEDAKCPFRSAVELFDDERSRQKLIWLWGLSKNFSLPGLRAAVIHSPNPIVRTAVTRFMMHHLPNCTTQFIMRQFLDDHEWVEKVFLPENLRRMREARDRTLHSLQLMGVRCLKPRAGFFVLADFSKFLDEPTFEAEQRLFERFMHSKVIITAGEACRMPTPGWFRIVFTSVNAKTLDQGLLRIRNALVETAGMKLRTGVLEWPFGNHRELGMGFLEDWNAVWLWCNGNWLMRCPKINTNVPVILMTIIGLLTCTISGGKKKESGQDGALNDLLGGLDLDGMLSGVQELLGKHAGGGSADGKKGDGLEKLKEMAANLDPKMLKDILGKMDTEKISQTIQNMVKPENIWEMLPAHVKEMLPEGWFLIGKKIGNVLSKEWDKIMELLDGVDKLGSMEELREELKKKAPILSDLLENDVWKGNKERWQKFEGNLGEEAKQYTENVKATGWEFLSRKVFAPALRLSPEAKMNLKDSLGNTLPALKPLLEKAATNKKLKEWAEQWQMMAELEAMFSKVQLATDGLKEKANGGGNAGRTEDEEGTKKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I225</accession>
    <name>A0A914I225_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g5896.t2">
        <property type="protein sequence ID" value="Gr19_v10_g5896.t2"/>
        <property type="gene ID" value="Gr19_v10_g5896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06673">
        <property type="entry name" value="PDZ10_MUPP1-PDZ8_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06674">
        <property type="entry name" value="PDZ11_MUPP1-PDZ9_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06669">
        <property type="entry name" value="PDZ5_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06670">
        <property type="entry name" value="PDZ6_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000070">
        <property type="entry name" value="Multiple PDZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000038">
        <property type="entry name" value="Multiple PDZ domain protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="304"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="458"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="648"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="880"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1194"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1379"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1607"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1707"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1977"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1503"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1806"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1867"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1151"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1504"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1517"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1811"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1842"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1888"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1920"/>
            <end position="1929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g5896.t2"/>
        </source>
    </evidence>
    <sequence length="2060" mass="222483" checksum="F7CB348704EC8304" modified="2023-02-22" version="1">MLTGDWVQVQIVHLPNEPEGLGFGIVGGHSTGVVVKSLIRGSVADKDMRLRPGDRILQIGHISTQGLNSQQVAALLRQQNAVVQLTVVRPIQLQDSDQDTPLCWTMSTRAALSADILDEEVQARLEAFAKSRNKSCNGLHHHPKCPHGHAQLHQQHIAAGGAAEALSEGTEYPDQLALHNHHHYNHQTTTATTTEDTADAMMDMTNQPSTSTAGMQNECGGSHGHQIWAQSADKIGPTELLNSAGNTTSSSSRRRRGRTSRGPSNDNPSCSSSSDRLSLKQLQEMALTSFCRDKWTPGKFREIQIELERDKHIGLGITVAGYVYKKEEISGVFIKSLVPQSSAHLSRQIQLHDLIVEVNGRRLEGLSHAESVRTLIRSGHRVRLKLIRFEEGTPQAKCLKMLHEQELAAASQIESAGSSSTAATVPPIVQTQQQYEQSLVDYKSYWATRLGPEYDIVLVDVRPDERVIEDGGLGIEWQGTVDICDGSQLCSHHFIESMRKDGPAAKTGALKAGDELLQVNETALFGESFVRVRNELNSAQKSCQFVRLIFCRRAEKEHINFVMPSSEQSLPLAYPILATMMALDEHFIKAKSELRLADLASAAENGPSTTVRCRTASAAAAVAASRWKRSRSLENLSGFAVWHCVPIVVTLRKDARGLGFSVADYQDPSHPAERVIVIRSLVPGGAAQADGRIVPGDRLLFVNGEDLSSSSLERAVEVLKAAPIGQIVRLGIAKPVPIEQCRLDDTVPLISHSERLLAKSHSPRGRRRREPFGDHLLLNAQRHSLITSNPSSACSSQEEIWVGGHLERSLNPQLYFPSTTDSRCSPLASPQSRLSSGMQTTTAWSPCSSRSLSPCASPASSLKGSWSYDITNLPSHLERHIKVLKAHLPLGVVLDANVDKAINGCVVKSICSKKALAKDGRIQPVDHIVKVNGESLRNVTNAQARAIMRRANLVGAQCGISYITSSDAKLWKERFQRGIVEMGNLTDGTTANAAEQLQQQQQQDQLQSRLSPKVYPKFYRSPILDVPFESSESLSPSADTIAAITVFQVENFVDKLLKSIFADAMFDVYILDRPELQARHTVRPNRSASVAIEAATVVEMPTVSMPTTTRRASTMVQGLIRTASSSLKRKTRRPTPPTEQQHHRQIEEVSAASTSKMSPVHQTMAPPTAEEAKQFSEMMPEPAKAMNFWSEPRAVTLNRIHNETFGISIVGGRVEVSQRADNGTSVPICGSGTGPPASSKTVSGIFIKSVVPDSPAGRSGQLFMGDRVLAVNDSDLTNTTHEHAVQVIKSAKNPVKFVVQSLQSLQAFVPSSSTKQSIVEVAEVGGTSGAAPTVAVDLDPDSAAALERLEDDVEAEDAFRYTESKVVRKYAHLPGHPVLIRLRDIPRGGLGLILSARGSQNAAAIVVGVKSDSPLSLNVGDELLEINGKVLFGLSHHEATEKIKQCCAHNCLTLLVLRKHPTEFEFPQHRERKFTAESECEAGARKIVSEVLSAAGADEIEAEDVGHPDQNAKENSTKMTMPSTSSYRTRPRTATGGESTVTKTGSRSSTTVASSSHCLQAVNNNNNDSNNNNAIGGEATRKRSWQMEQQQSLQLQKAPIHVGQETLIEIDKDGKGLGLSIVGGSDTVLGTVVIHEVYPDGAAAIDARLKPGDQVLEVNGTSLRGTPHEQAISLLRRTPAKVRLLIYRDVNLQMSMLDPAQIYNILSIELTKKSGGKGLGISIVGRKNEPGVYISEIVKGGVADNDGRLMQGDQILEVNGQDVANCLQEDVATILKTCTGRVQLKVGRWKLTETALRSAQAPNYATNAVGQQHQQQQQNTAANNEDNSNNWLSEHPNGALREPPPPAPMPKLQPPTLQITLHDENNQQQSLAGRTDLSPVSEEDLKSIAETSASEETNSSQRRPLTGSGAGGSHSYLPASSAGSQQSAGGTSGGGRSSGGVTVSSSSHAGYTTVPSAAVTNTVLRSDLKESGCESALILLKKDEGQQWGMGIGKRPRGILITSLQPGSSAAEKLAIGDRIMAVNGHEVITQHSAVTYIRSSGNSVALQVSRPIKPPAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I229</accession>
    <name>A0A914I229_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I229"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g11033.t2">
        <property type="protein sequence ID" value="Gr19_v10_g11033.t2"/>
        <property type="gene ID" value="Gr19_v10_g11033"/>
    </dbReference>
    <dbReference type="WBParaSite" id="Gr19_v10_g6785.t2">
        <property type="protein sequence ID" value="Gr19_v10_g6785.t2"/>
        <property type="gene ID" value="Gr19_v10_g6785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275815" evidence="2">
        <location>
            <begin position="23"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g11033.t2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6785.t2"/>
        </source>
    </evidence>
    <sequence length="222" mass="25067" checksum="EADE72522368A35F" modified="2023-02-22" version="1">MKLYAFVLIGLAILALSAICKAGKKEEEAVKDEVHPMDVAYDAMYAQVKRKNRGKAWTQDAAQTMGWNTQHYPDGQLKKQKHHGEVLNACQKITAGPGTDNNPCKMKEDTTPYGQEPSSNPSDTHDYTTPYAQEPSSNPSDTHDYTTPYGQEPSSNASFQKNDDMESQGQAPYSNLLPAIDYHTNEYEDNEYWYGTHHPDDTLILPHHGNDYNWEYGQMKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I3A6</accession>
    <name>A0A914I3A6_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I3A6"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6436.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6436.t1"/>
        <property type="gene ID" value="Gr19_v10_g6436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6436.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8965" checksum="2C654A79C2DFA397" modified="2023-02-22" version="1">MVAAKFFFRIDETTTAERREILSKAATSARTPTEDLLIKMTLEAMGHAARMERLITEYLRRGGGSVADSDVHRREQTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4J9</accession>
    <name>A0A914I4J9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4J9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g6548.t1">
        <property type="protein sequence ID" value="Gr19_v10_g6548.t1"/>
        <property type="gene ID" value="Gr19_v10_g6548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037800757" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g6548.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14014" checksum="2671F5C6ABAF43A4" modified="2023-02-22" version="1">MNAPFYFLISLILPCLCSGLLQCKSGMYNNAGLAYIQILNCTEKESYCSAVSCVGADLVTMLWGCDEHNNCTEIADRVSDENTTCRCKMGEKGVNLSNVKLSFPPEAQTVTTEGITYLFLTAGVRFSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4L8</accession>
    <name>A0A914I4L8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I4L8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g726.t1">
        <property type="protein sequence ID" value="Gr19_v10_g726.t1"/>
        <property type="gene ID" value="Gr19_v10_g726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g726.t1"/>
        </source>
    </evidence>
    <sequence length="596" mass="68531" checksum="ECD3FC246D721EC8" modified="2023-02-22" version="1">MFVGAKPVFLVWAPNWSRAKLVTPNWLVTPNWSRQTSRAPNWSRQVGHAKLVTPNWSRAKLVTPNWLVTPNWLVTPNWLVTPNWSVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWSCAKLVGHAKLVGPPNWWHATGAPNWLVTQTGCHANWLHAKLVGTPNWLVTPNWSVAWLVTPGWSRQTGWSPMARQTGGHANWLVTHWLVTHWLVTPNWLVRQTVGHAKLVVTPNWLVTPNWSVTQTVGHAKLVGHANTPTVGHAKLVSRQWFRQWWVTPNWLVTPNWWSRQHWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPNWLVTPMVAPNWLVTPNWLVTPNWSRAKLVTPNWLVTPNWLVTPNWWSRQTGWSRQTGGHAKLVGHANWFGTPNWLVTPNWLVPPKMVGHATLVRFTTNWLVTPTWLVTPNWFVTPKTGGHAKWLDHAKLVGSRQNWSVPPTGLVTPNWLVTPNWLVPPLVAPNWLDHAKLVGHAQLVVSRKLGWSRTNWLVTPMVGAKLVLVTPNWLSRTNWSRAQTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I4Q9</accession>
    <name>A0A914I4Q9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Has roles in embryogenesis and ovulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR. Interacts with V-type proton ATPase subunits a1 unc-32, a2 vha-5 and a3 vha-6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I4Q9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g729.t1">
        <property type="protein sequence ID" value="Gr19_v10_g729.t1"/>
        <property type="gene ID" value="Gr19_v10_g729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037988645" description="V-type proton ATPase subunit C" evidence="11">
        <location>
            <begin position="26"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g729.t1"/>
        </source>
    </evidence>
    <sequence length="598" mass="67193" checksum="17F56A0458F60673" modified="2023-02-22" version="1">MMTNSSNNHFLLFLCLLLCTHYAHSEDDDDTKRCPKWISSKQKKVFEKCVLEYKQFCGRITCARPGKTEEHLMGCVEEDFCMIGEDNCSALTHDPKPQFKMCSVYGPYIGPISEETDKPPPPAVATSPKGSVSELTTQKSVPSANVTETPKPTEPFVPSANVTETPKPTEPFVPSANVTETPKPTEPIVSTTMASGAGSAAIMFGIFLQAIVVAVASLLNRWILCFQFAGHKFSTICRLSTITQNLSTNSKFNIPDLKVGTLDQLVGLSDDLAKLDTATEQTTRKLVQYFSEVLEEERNKLLENLVVSGKDMRTYVTKFQWEAARYPVKQSLKALSELIGKQVSQIENDLKTKAAAYNSLKNALSSIDRKTAGSLITRDLSDLVKAEDFVLGSEYMQTVCVVVPKLLAKEWESKYHTFAQMVVPGSACKIVEDADHVLYTVTLFQKVLDEYKTACREQKFIVRDFVYDEQSLKAGKSERDKLVQEKQRQYAPLVRWLKINFGEIFCAYVHVKALRVFVESVLRYGLPVNFMAAIMEPQKNAQKRLRVELNKLYQHLDGTASGPIEAFEDAPTLMSLGVHDYLPYVFFKMNVDFFEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I738</accession>
    <name>A0A914I738_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914I738"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7908.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7908.t1"/>
        <property type="gene ID" value="Gr19_v10_g7908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7908.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10901" checksum="776478296FF95BA8" modified="2023-02-22" version="1">MLVSLNEPVKTNLGKSEWLRAAPTQDDVGTEISAELITGERKGKGKVEQRMHFPRQEMKTDDPCAPTLGFAHRSMAWDVGGDHPGVIPVLRGRVCEGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I7H9</accession>
    <name>A0A914I7H9_GLORO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I7H9"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7628.t1">
        <property type="protein sequence ID" value="Gr19_v10_g7628.t1"/>
        <property type="gene ID" value="Gr19_v10_g7628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF30">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7628.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28751" checksum="0DA9EAD2D3607979" modified="2023-02-22" version="1">MNQRLFCQIKPKSNIQKARDYSFVVQLSSSALLSQPFFDLLAKNPFNFAIPIWRLNRRCRTKKLSGENAIDGSEESKIHLWRPINGGYGFGGYGNGMMSAGYGGAGMYSYGMAMPFVHFGSDEYILFDFWHPFAPLGMAMSCLFVLVIAAGFEAIRWFRHICGRRAELVMPSDQTHNNGTLSSGNNPMMLAFGNVKVRFRAAAVDVLLYGVQLLISYALMIIVMTLNGWLILSVVIGQIVAKLLLRLITLDSMPQGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914I9J8</accession>
    <name>A0A914I9J8_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914I9J8"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g7955.t3">
        <property type="protein sequence ID" value="Gr19_v10_g7955.t3"/>
        <property type="gene ID" value="Gr19_v10_g7955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097169">
        <property type="term" value="C:AIM2 inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072557">
        <property type="term" value="C:IPAF inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072559">
        <property type="term" value="C:NLRP3 inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF3">
        <property type="entry name" value="CASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="5">
        <location>
            <begin position="734"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="4">
        <location>
            <begin position="890"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="634"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="865"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g7955.t3"/>
        </source>
    </evidence>
    <sequence length="982" mass="109096" checksum="ED25467E78FD2C89" modified="2023-02-22" version="1">MEILSIPPPPQQSVLCDYRLLKSGPFTPPPPRALPSQIRRVLLHCKVNGRKRAAAAAAVASSSSCSSSSSTVDESAGRRTSNDEDDNSRRLRPFLGKNPGGDKRSDQQLISMFGDGSDQKAARGLFSTNVRAPTCQTGRRGRCNSFANGNTCSTIATTTRRTITMWQFCRHDICRATNKYDTLGLAELGPSLRTTACQPRSPSRTSLATCSTFRMTTSGSVPSSCRRSTNTVNTSWCPRWNGMAQTQCLFDKPTERRYYEKMFETPAPGAFYTVSQQCKFVFGAAAEISVHSVLSSIVVLRKLGVEHSTCLWPTRRPAGTTCGAIGDNVSACRQCSSNSLTEDGAIGGHGESVRAHAEKVSKRHSGIATRHDPRMAANIVLGSGSAIGHAMFRTAPGTCPVLMSFNDSDIGIHGVPKEMKWAPKYTGVGDNERCRLYCRGTDSAAFYLLKDTVADGRPCDRNGDDICIDGTCHKAGCDHRLGSEMKRDVCGVCGGNGSSCRAVNGLYNERSTFGYNEVLRIPAGNSVCGVSAPLDQQCHGKEQKQTEKCSPGPCPYWRAAEWGQCSVRCGQSFRTRHVECVLKGQIVDDSLCMEAMRPKTNDRCVLLACAIWNAEPWSSVHFLLKHFDWHKMSKRKSRRRTPRERKREQTTRKTNQESSESDSEVGSLDYSELESEDSDTPLSPISPVEIAEEIEAGNFANLKTLLFKSMAEQSVRQWNVDDEDEVYSPNLNVIRGRALIINNHKFTRMKNRDGTNVDRERMFHLLKLLRYDTTIKDNLRARQMLKAVAKFSKEADHNSADSVVLVILTHGSSGKLFGIDDKYCFVDDLLGPLNNKNCGRLAGKPKLIFLQCCRGGKTDTGVSHGRNESATRAQDQRRDSPRRIRAPSEQLRRLPTDADFLICFSTTDYRVSWRSRLRGSRFIQAICECFARYAAVDDVLHLMTRVNGVVAAMYSNRKLSFMQVSEERYTLTKLFFFFPNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBJ2</accession>
    <name>A0A914IBJ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBJ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9319.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9319.t1"/>
        <property type="gene ID" value="Gr19_v10_g9319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037598014" evidence="1">
        <location>
            <begin position="22"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9319.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34550" checksum="0DE040FC154AC5A9" modified="2023-02-22" version="1">MYFFNIENLIIFLVILRNAQSVGFCETPKVADFAKRPKWRILRNAQSGGFCETPKVADFAKRPKWRILRNAQSGGFCETPKVADFAKRPKWRILRNAQSGGFCETLKVSDFAKRSKWRILRNAQSGGFCETLKVADFAKRPKWRILRNAQSGGFCETLKVSDFAKRSKWRILRNAQSGGFCETPKVADFAKRPKWRILRNAQSGGFCETPKVADFAKRPKWRILRNAQSGGFCETPKVADFAKRSKCRILRNAQSGGFCETPKVADFAKRPKWRILRNTQSGGFCETPKVAGFAKHPKWRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IBQ2</accession>
    <name>A0A914IBQ2_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DJ-1/PfpI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914IBQ2"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9364.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9364.t1"/>
        <property type="gene ID" value="Gr19_v10_g9364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046295">
        <property type="term" value="P:glycolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000015">
        <property type="entry name" value="Protein DJ-1 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9364.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="19810" checksum="F9E6994E21433E28" modified="2023-02-22" version="1">MSTKTALVIASNDSEESELVITVDVLRRAGVNVTIASLQDEKIIHCHEGINIQVDALLSDVQDDMFDAVILPGGPGAQNLADDERVGRILERHNHNGKVIGAICGGPQALASHKIASGAQITAYPAMQDKFNNYNFQKDARVCVCKNLITSQAPGTAFEFGVDIAKQLVGAEKAEEVRNFLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICA7</accession>
    <name>A0A914ICA7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICA7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9509.t1">
        <property type="protein sequence ID" value="Gr19_v10_g9509.t1"/>
        <property type="gene ID" value="Gr19_v10_g9509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150:SF3">
        <property type="entry name" value="CC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150">
        <property type="entry name" value="PROTEIN CBG08832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9509.t1"/>
        </source>
    </evidence>
    <sequence length="541" mass="59850" checksum="EA82C55567F1EE57" modified="2023-02-22" version="1">MCGKFPNRYFSYEPCPEDEQQQEQKQRVREELPPRRDQQQICSRQGWQPIGIRCQNVNDCYQHRENVAMMCERNQCCSPVSPVTSAPDVRGAGGAGGGRSAGPTSDGSDTYLWWQTCENGGYFTGQTCRTTADCRQGYGQGGQRLDQRLARYEQICLQGECCTTNRELDQENGIPNPNPNPNPNPNRNPNPNPNPNRNPNPNPNTNPNRRPLYPTHPTNNGHSCETFNGGRLVRNAPCRRHTDCNRFVGGQNGDLARVGDTQQLACVAQQCCLMTRQLPPGIIDWQQLCPLRQGSFTGMFCHQSDADCTTASSRWGGGAQQQHQSLVCELNRYCCTSVIDRNRRQNQGCDDGDMITGSRCVDDRDCYRGEYCGDLKICCLPKRTAQPEEPSYPPAGQRTREAPAAYCYNGEQSSVPCEFQRDCLDTQTCMNGLCCVRSGNEWKGACGGAMAVSNCFQDRTCHDNLVCSTSDYCCECPHGQTTGKCTHGCPPNFACSSNGFCCPRCASGEQPYGSCFNMRCSAGYTCVAGNICCPNEARTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICN4</accession>
    <name>A0A914ICN4_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone H2A/H2B/H3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ICN4"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8665.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8665.t1"/>
        <property type="gene ID" value="Gr19_v10_g8665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8665.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17163" checksum="CC566B6032EBFFE0" modified="2023-02-22" version="1">MSTQSSQTLSISTQGSKSDSQGTVISRGLIGGRPRIGAKARLLDDQEEIRRPKRHRPGVKALQEIRKYQKSTATLVPREPFRRLVNEIVLEMTGRTLRVEAEAITALQEAAEALLVTVFEAANRCAIHGHRMTVMPSDFALVRWILNTFGNKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ICS7</accession>
    <name>A0A914ICS7_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ICS7"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g8700.t1">
        <property type="protein sequence ID" value="Gr19_v10_g8700.t1"/>
        <property type="gene ID" value="Gr19_v10_g8700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g8700.t1"/>
        </source>
    </evidence>
    <sequence length="704" mass="81139" checksum="94636FA1A42FD863" modified="2023-02-22" version="1">MANKRVALKNLYDFDERLRCYEQAFSHDEHLNPKITNSEWTIQFVKDVFESLGNPNAEQWCYNQFIKLFVDLNFDIGQVHYDKLCAWLLKDGLNIAKECIKNHSEIGPKAMEAWGIALKILGKQVLRSTETTNSCVSIFSLAIKSNNVLTIKEAYRAWKAIVTIFAKDPTWTSVEMPRDKSSRVNQSRLQLIMTALRYKKLPVEISSEVFDCWWTCCNSLGPRLVAEFEDIAHSFMRFCVGGSPNFLRSIAKFDSIFSEVSKQLEPTTHVFFVMNQKLEKSTYAQHKWNDNAHFKVRLIDLLESLLSESPALLNEPGFCCFNDPQIVKDHSVFAVQCIRHCDQRCVDAADRDSLSERISNLMCAVLEKITTKLADDDCAAQQTLFLAQFDAWLKESTLPNETLLRTFKKLQIDSIVSQIVEKASTYGKYTDKLKESLNEWKNKQFDGRKKTLNSLCIRNPNDQLMLTKLAAAAPYEQQMNTCGYGEDGTTSGLEIDEQQKEWEDEKRTEKKEEERKQSQEGKEEAEKEEMEKEGKWTEETVSKGEETKVADKEENVEEELNEREDEEETRKSEEQETGKGGEEEEKEAEKEVEEEKKVEDNGDKEEEEKVEKEGKDEQETMKTGEEAEKEEKGEEGKKAELSMEETEKGEEDKEEALMEDVSGKEADALEEIWEANEIELVEEPTEDSNERDRERIATKNVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ID78</accession>
    <name>A0A914ID78_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ID78"/>
    <dbReference type="WBParaSite" id="Gr19_v10_g9527.t2">
        <property type="protein sequence ID" value="Gr19_v10_g9527.t2"/>
        <property type="gene ID" value="Gr19_v10_g9527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="Gr19_v10_g9527.t2"/>
        </source>
    </evidence>
    <sequence length="370" mass="42372" checksum="E5AE229D191CC811" modified="2023-02-22" version="1">MRRSVVVALYKPNFSKRYTVNLGSMESSEIYWHRRIFMERKSGDILPGNFHAFLYAYARKNRPENVNLYEMPEQQKLLGYAPMVLNTLGNMPSTADNAIQRQRISEYRLSIPIDLKSLFKHKILSLGLYVFQFNESDLKENDVEINKNSNESDQLSWPPPDSVGQTQSARLSWPRLSRPDSVVPYRKKVHAFHSDCIKKWIEILEKIRCPLCNKEPELKIVGECLPIFSGPSEVPPLGVYANPLAELCRRAQNAADGTFIKAQSQFALDSIVRRLSKAETAVRHLLANDLHFLLLVGDDQPLFSIGSEGFVENGEFLQNIRKALENPQKILQKHREKFHKALALIQWAKIFQSSEANDALESMQLISEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914IDD9</accession>
    <name>A0A914IDD9_GLORO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multiple epidermal growth factor-like domains protein 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Globodera rostochiensis</name>
        <name type="common">Golden nematode worm</name>
        <name type="synonym">Heterodera rostochiensis</name>
        <dbReference type="NCBI Taxonomy" id="31243"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Tylenchomorpha</taxon>
            <taxon>Tylenchoidea</taxon>
            <taxon>Heteroderidae</taxon>
            <taxon>Heteroderinae</taxon>
            <taxon>Globodera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="Gr19_v10_g8869.t2">
        <property type="protein sequence ID" value="Gr19_v10_g8869.t2"/>
        <property type="gene ID" value="Gr19_v10_g8869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887572">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000041">
        <property type="entry name" value="matrilin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037426075" evidence="9">
        <location>
            <begin position="30"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="11">
        <location>
            <begin position="46"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="211"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
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            <end position="658"/>
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    </feature>
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            <end position="701"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
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    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="888"/>
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    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="931"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="969"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1183"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1312"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1418"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1458"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="158"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="415"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
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